Protein Description O81 O83 O121 H80 H84 H120 O81-vs-O83 O81-vs-O83-p H80-vs-H84 H80-vs-H84-p O121-vs-O83 O121-vs-O83-p H120-vs-H84 H120-vs-H84-p BP_GO_ID BP_GO_Desc BP_GO_Level CC_GO_ID CC_GO_Desc CC_GO_Level MF_GO_ID MF_GO_Desc MF_GO_Level KEGG_KO KEGG_Pathway_ID KEGG_Pathway_Desc Domain_ID Domain_Desc SubcellurLocation COG_Gene BlastScore COG_Code COG_Desc Q8NCL4 Polypeptide N-acetylgalactosaminyltransferase 6 OS=Homo sapiens OX=9606 GN=GALNT6 PE=2 SV=2 - [GALT6_HUMAN] 0.956 1.011 1 1.101 0.998 1.52 0.945598417 nan 1.103206413 nan 0.989119683 nan 1.523046092 nan GO:0044249;GO:0044237;GO:0034645;GO:0043170;GO:0009100;GO:0009101;GO:0044699;GO:0044267;GO:0044710;GO:0006486;GO:0071704;GO:0036211;GO:0043687;GO:0016266;GO:1901576;GO:0009987;GO:0070085;GO:0006464;GO:0044260;GO:0043412;GO:0043413;GO:0008150;GO:0008152;GO:0044723;GO:0005975;GO:0044238;GO:0006493;GO:0019538;GO:1901135;GO:0009058;GO:1901137;GO:0009059;GO:0044763; cellular biosynthetic process;cellular metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;single-organism process;cellular protein metabolic process;single-organism metabolic process;protein glycosylation;organic substance metabolic process;protein modification process;post-translational protein modification;O-glycan processing;organic substance biosynthetic process;cellular process;glycosylation;cellular protein modification process;cellular macromolecule metabolic process;macromolecule modification;macromolecule glycosylation;biological_process;metabolic process;single-organism carbohydrate metabolic process;carbohydrate metabolic process;primary metabolic process;protein O-linked glycosylation;protein metabolic process;carbohydrate derivative metabolic process;biosynthetic process;carbohydrate derivative biosynthetic process;macromolecule biosynthetic process;single-organism cellular process; 4;3;5;4;5;6;2;5;3;4;3;5;7;6;4;2;5;6;4;5;6;1;2;4;4;3;5;4;4;3;5;5;3; GO:0043229;GO:0005737;GO:0031090;GO:0043227;GO:0016021;GO:0016020;GO:0044431;GO:0043226;GO:0031224;GO:0048471;GO:0005794;GO:0098588;GO:0044446;GO:0012505;GO:0044425;GO:0043231;GO:0000139;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422; intracellular organelle;cytoplasm;organelle membrane;membrane-bounded organelle;integral component of membrane;membrane;Golgi apparatus part;organelle;intrinsic component of membrane;perinuclear region of cytoplasm;Golgi apparatus;bounding membrane of organelle;intracellular organelle part;endomembrane system;membrane part;intracellular membrane-bounded organelle;Golgi membrane;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part; 3;4;3;3;4;2;4;2;3;5;4;4;3;3;2;4;5;2;2;3;1;4;3;2; GO:0030246;GO:0003674;GO:0008376;GO:0043167;GO:0004653;GO:0016740;GO:0043169;GO:0046872;GO:0003824;GO:0008194;GO:0016757;GO:0016758;GO:0005488; carbohydrate binding;molecular_function;acetylgalactosaminyltransferase activity;ion binding;polypeptide N-acetylgalactosaminyltransferase activity;transferase activity;cation binding;metal ion binding;catalytic activity;UDP-glycosyltransferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;binding; 3;1;6;3;7;3;4;5;2;5;4;5;2; K00710 map00512;map01100; Mucin type O-Glycan biosynthesis;Metabolic pathways; IPR000772;IPR001173;IPR029044; Ricin B, lectin domain;Glycosyltransferase 2-like;Nucleotide-diphospho-sugar transferases; extracellular Hs6005766 1300.0 O [O] Posttranslational modification, protein turnover, chaperones; Q96I99 Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2 - [SUCB2_HUMAN] 0.843 1.091 1.212 0.714 1.244 1.019 0.77268561 nan 0.573954984 nan 1.110907424 nan 0.819131833 nan GO:0044281;GO:0072350;GO:0044710;GO:0043436;GO:0055114;GO:0051186;GO:0035383;GO:0008150;GO:0008152;GO:0015980;GO:0006104;GO:0045333;GO:0006637;GO:0006732;GO:0044699;GO:0009987;GO:0006082;GO:0009060;GO:0019752;GO:0006099;GO:0006091;GO:0071704;GO:0006101;GO:0044763;GO:0044238;GO:0044237;GO:0006790;GO:0006793; small molecule metabolic process;tricarboxylic acid metabolic process;single-organism metabolic process;oxoacid metabolic process;oxidation-reduction process;cofactor metabolic process;thioester metabolic process;biological_process;metabolic process;energy derivation by oxidation of organic compounds;succinyl-CoA metabolic process;cellular respiration;acyl-CoA metabolic process;coenzyme metabolic process;single-organism process;cellular process;organic acid metabolic process;aerobic respiration;carboxylic acid metabolic process;tricarboxylic acid cycle;generation of precursor metabolites and energy;organic substance metabolic process;citrate metabolic process;single-organism cellular process;primary metabolic process;cellular metabolic process;sulfur compound metabolic process;phosphorus metabolic process; 4;7;3;5;4;4;4;1;2;4;6;5;5;5;2;2;4;6;6;4;4;3;8;3;3;3;4;4; GO:0031974;GO:0016020;GO:0043231;GO:0043232;GO:0043233;GO:0044429;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005815;GO:0005759;GO:0015630;GO:0005886;GO:0005575;GO:0070013; membrane-enclosed lumen;membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;mitochondrion;cell part;cell;intracellular;cell periphery;microtubule organizing center;mitochondrial matrix;microtubule cytoskeleton;plasma membrane;cellular_component;intracellular organelle lumen; 2;2;4;4;3;4;3;2;3;3;3;2;5;4;3;4;4;5;5;2;2;3;3;5;5;6;3;1;4; GO:1901363;GO:0000166;GO:0035639;GO:0004774;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0005525;GO:0043168;GO:0003824;GO:0016878;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0043167;GO:0032561;GO:0030554;GO:0016405;GO:0001883;GO:0001882;GO:0019001;GO:0004776;GO:0036094;GO:0016874;GO:0016877; heterocyclic compound binding;nucleotide binding;purine ribonucleoside triphosphate binding;succinate-CoA ligase activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;GTP binding;anion binding;catalytic activity;acid-thiol ligase activity;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ion binding;guanyl ribonucleotide binding;adenyl nucleotide binding;CoA-ligase activity;purine nucleoside binding;nucleoside binding;guanyl nucleotide binding;succinate-CoA ligase (GDP-forming) activity;small molecule binding;ligase activity;ligase activity, forming carbon-sulfur bonds; 3;4;5;6;3;1;2;4;5;5;6;6;4;2;5;3;6;5;6;4;3;6;6;5;5;4;6;7;3;3;4; K01900 map00020;map00640;map01100;map01110;map01120;map01130;map01200; Citrate cycle (TCA cycle);Propanoate metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism; IPR017866;IPR005809;IPR013650;IPR005811;IPR013815;IPR016102;IPR034722; Succinyl-CoA synthetase, beta subunit, conserved site;Succinate--CoA synthetase, beta subunit;ATP-grasp fold, succinyl-CoA synthetase-type;ATP-citrate lyase/succinyl-CoA ligase;ATP-grasp fold, subdomain 1;Succinyl-CoA synthetase-like;Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; mitochondria Hs22041509 870.0 C [C] Energy production and conversion; Q9NQ79 Cartilage acidic protein 1 OS=Homo sapiens OX=9606 GN=CRTAC1 PE=1 SV=2 - [CRAC1_HUMAN] 0.853 0.972 1.28 0.982 0.883 0.743 0.877572016 0.466268335 1.11211778 0.503146091 1.316872428 0.193511898 0.841449604 0.286667308 GO:0021537;GO:0048666;GO:0051098;GO:0048856;GO:0030030;GO:0021772;GO:0030154;GO:0021988;GO:0060322;GO:0031175;GO:0007413;GO:0044699;GO:0007417;GO:0008037;GO:0032091;GO:0048869;GO:0071840;GO:0016043;GO:1900120;GO:0065007;GO:0044092;GO:0065009;GO:0032502;GO:0032501;GO:0061564;GO:0030182;GO:0048468;GO:0009987;GO:0048699;GO:0051100;GO:0044767;GO:0008150;GO:0048731;GO:0022008;GO:0048513;GO:0008038;GO:0007420;GO:0044707;GO:0007399;GO:0044763;GO:1900121;GO:0030900;GO:0007275;GO:0043393; telencephalon development;neuron development;regulation of binding;anatomical structure development;cell projection organization;olfactory bulb development;cell differentiation;olfactory lobe development;head development;neuron projection development;axonal fasciculation;single-organism process;central nervous system development;cell recognition;negative regulation of protein binding;cellular developmental process;cellular component organization or biogenesis;cellular component organization;regulation of receptor binding;biological regulation;negative regulation of molecular function;regulation of molecular function;developmental process;multicellular organismal process;axon development;neuron differentiation;cell development;cellular process;generation of neurons;negative regulation of binding;single-organism developmental process;biological_process;system development;neurogenesis;animal organ development;neuron recognition;brain development;single-multicellular organism process;nervous system development;single-organism cellular process;negative regulation of receptor binding;forebrain development;multicellular organism development;regulation of protein binding; 4;5;4;3;4;4;5;4;4;5;6;2;5;4;6;4;2;3;6;2;4;3;2;2;6;6;4;2;7;5;3;1;4;6;4;5;4;3;5;3;7;4;4;5; GO:0030427;GO:0030426;GO:0031012;GO:0043227;GO:0043226;GO:1903561;GO:0070062;GO:0097458;GO:0043005;GO:0042995;GO:0031982;GO:0043230;GO:0044463;GO:0044464;GO:0005623;GO:0005578;GO:0005575;GO:0005576;GO:0044421; site of polarized growth;growth cone;extracellular matrix;membrane-bounded organelle;organelle;extracellular vesicle;extracellular exosome;neuron part;neuron projection;cell projection;vesicle;extracellular organelle;cell projection part;cell part;cell;proteinaceous extracellular matrix;cellular_component;extracellular region;extracellular region part; 3;4;2;3;2;3;4;3;4;3;4;3;3;2;2;3;1;2;2; GO:0003674;GO:0005488;GO:0043167;GO:0005509;GO:0046872;GO:0043169; molecular_function;binding;ion binding;calcium ion binding;metal ion binding;cation binding; 1;2;3;6;5;4; IPR001881;IPR011519;IPR018097;IPR027039; EGF-like calcium-binding domain;ASPIC/UnbV;EGF-like calcium-binding, conserved site;Cartilage acidic protein 1; extracellular 375012056 88.6 S [S] Function unknown; COG3291 PKD repeat Q9NPI9 Inward rectifier potassium channel 16 OS=Homo sapiens OX=9606 GN=KCNJ16 PE=1 SV=1 - [KCJ16_HUMAN] 2.017 0.966 0.256 1.344 1.034 nan 2.087991718 nan 1.299806576 nan 0.265010352 nan nan nan GO:0023052;GO:0030001;GO:0010107;GO:0044699;GO:0071804;GO:0071805;GO:0055085;GO:0015672;GO:0098662;GO:0006810;GO:0006813;GO:0006812;GO:0006811;GO:0009987;GO:0034220;GO:0044765;GO:0044763;GO:0007268;GO:0007267;GO:0007154;GO:0051234;GO:0051179;GO:1902578;GO:0044700;GO:0098660;GO:0098916;GO:0008150;GO:0098655;GO:0099536;GO:0099537; signaling;metal ion transport;potassium ion import;single-organism process;cellular potassium ion transport;potassium ion transmembrane transport;transmembrane transport;monovalent inorganic cation transport;inorganic cation transmembrane transport;transport;potassium ion transport;cation transport;ion transport;cellular process;ion transmembrane transport;single-organism transport;single-organism cellular process;synaptic transmission;cell-cell signaling;cell communication;establishment of localization;localization;single-organism localization;single organism signaling;inorganic ion transmembrane transport;anterograde trans-synaptic signaling;biological_process;cation transmembrane transport;synaptic signaling;trans-synaptic signaling; 2;7;6;2;4;5;4;7;7;4;8;6;5;2;5;4;3;8;4;4;3;2;3;3;6;7;1;6;5;6; GO:0098590;GO:0005886;GO:0071944;GO:0034703;GO:0031226;GO:0098797;GO:0098589;GO:0016021;GO:0016020;GO:0031224;GO:0044425;GO:0044459;GO:1902495;GO:1990351;GO:0008076;GO:0016323;GO:0005887;GO:0043234;GO:0032991;GO:0044464;GO:0005623;GO:0005575;GO:0098796;GO:0034702;GO:0034705;GO:0098805; plasma membrane region;plasma membrane;cell periphery;cation channel complex;intrinsic component of plasma membrane;plasma membrane protein complex;membrane region;integral component of membrane;membrane;intrinsic component of membrane;membrane part;plasma membrane part;transmembrane transporter complex;transporter complex;voltage-gated potassium channel complex;basolateral plasma membrane;integral component of plasma membrane;protein complex;macromolecular complex;cell part;cell;cellular_component;membrane protein complex;ion channel complex;potassium channel complex;whole membrane; 4;3;3;6;4;4;3;4;2;3;2;3;4;4;5;4;4;3;2;2;2;1;3;5;7;3; GO:0005267;GO:0005261;GO:0003674;GO:0060089;GO:0005244;GO:0099600;GO:0005242;GO:0015077;GO:0015276;GO:0005215;GO:0022857;GO:0015267;GO:0004872;GO:0022803;GO:0046873;GO:0022891;GO:0005216;GO:0022890;GO:0022892;GO:0008324;GO:0022843;GO:0022838;GO:0022836;GO:0022832;GO:0005249;GO:0022834;GO:0015075;GO:0015079; potassium channel activity;cation channel activity;molecular_function;molecular transducer activity;voltage-gated ion channel activity;transmembrane receptor activity;inward rectifier potassium channel activity;monovalent inorganic cation transmembrane transporter activity;ligand-gated ion channel activity;transporter activity;transmembrane transporter activity;channel activity;receptor activity;passive transmembrane transporter activity;metal ion transmembrane transporter activity;substrate-specific transmembrane transporter activity;ion channel activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;cation transmembrane transporter activity;voltage-gated cation channel activity;substrate-specific channel activity;gated channel activity;voltage-gated channel activity;voltage-gated potassium channel activity;ligand-gated channel activity;ion transmembrane transporter activity;potassium ion transmembrane transporter activity; 8;7;1;2;7;4;7;8;6;2;3;5;3;4;8;4;6;7;3;6;8;5;6;7;9;5;5;9; K05009 map04971; Gastric acid secretion; IPR016449;IPR013518;IPR014756;IPR008061; Potassium channel, inwardly rectifying, Kir;Potassium channel, inwardly rectifying, Kir, cytoplasmic;Immunoglobulin E-set;Potassium channel, inwardly rectifying, Kir5; plasma membrane Hs8923823 876.0 P [P] Inorganic ion transport and metabolism; P22105 Tenascin-X OS=Homo sapiens OX=9606 GN=TNXB PE=1 SV=5 - [TENX_HUMAN] 0.877 0.829 1.432 0.884 0.85 1.691 1.057901086 0.494416146 1.04 0.657172807 1.727382388 0.017379552 1.989411765 0.098917807 GO:0019220;GO:0080090;GO:0019222;GO:0048583;GO:0007160;GO:0007165;GO:0071840;GO:0044710;GO:0043206;GO:0009966;GO:0000165;GO:0031589;GO:0060255;GO:0045859;GO:0032787;GO:0043436;GO:0046486;GO:0042325;GO:0044700;GO:0044707;GO:0019538;GO:0030199;GO:0030198;GO:0033554;GO:0044281;GO:0022607;GO:0006950;GO:0032963;GO:0046328;GO:0035556;GO:0071900;GO:0050789;GO:0044267;GO:0044260;GO:0043549;GO:0016043;GO:0065007;GO:0023014;GO:0065009;GO:0098602;GO:0006629;GO:0098609;GO:0050790;GO:0051716;GO:0050794;GO:0048251;GO:0036211;GO:0008150;GO:0008152;GO:1902531;GO:0050896;GO:0080135;GO:0043412;GO:0051338;GO:0085029;GO:0006631;GO:0016310;GO:0006639;GO:0006638;GO:0043405;GO:0023052;GO:0023051;GO:0010646;GO:0044699;GO:0043408;GO:0007254;GO:0097435;GO:0051246;GO:0031098;GO:0031399;GO:0022610;GO:0043170;GO:0006641;GO:0070302;GO:0009987;GO:0032872;GO:0030036;GO:0044259;GO:0044255;GO:0032268;GO:0006082;GO:0080134;GO:0016337;GO:0043933;GO:0031323;GO:0019752;GO:0032501;GO:0043506;GO:0071822;GO:0006796;GO:0071704;GO:0043062;GO:0006468;GO:0030029;GO:0006464;GO:0051174;GO:0051403;GO:0044763;GO:0007155;GO:0007154;GO:0006996;GO:0044238;GO:0007010;GO:0044237;GO:0044236;GO:1902589;GO:0044085;GO:0006793;GO:0001932; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of response to stimulus;cell-matrix adhesion;signal transduction;cellular component organization or biogenesis;single-organism metabolic process;extracellular fibril organization;regulation of signal transduction;MAPK cascade;cell-substrate adhesion;regulation of macromolecule metabolic process;regulation of protein kinase activity;monocarboxylic acid metabolic process;oxoacid metabolic process;glycerolipid metabolic process;regulation of phosphorylation;single organism signaling;single-multicellular organism process;protein metabolic process;collagen fibril organization;extracellular matrix organization;cellular response to stress;small molecule metabolic process;cellular component assembly;response to stress;collagen metabolic process;regulation of JNK cascade;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;cellular component organization;biological regulation;signal transduction by protein phosphorylation;regulation of molecular function;single organism cell adhesion;lipid metabolic process;cell-cell adhesion;regulation of catalytic activity;cellular response to stimulus;regulation of cellular process;elastic fiber assembly;protein modification process;biological_process;metabolic process;regulation of intracellular signal transduction;response to stimulus;regulation of cellular response to stress;macromolecule modification;regulation of transferase activity;extracellular matrix assembly;fatty acid metabolic process;phosphorylation;acylglycerol metabolic process;neutral lipid metabolic process;regulation of MAP kinase activity;signaling;regulation of signaling;regulation of cell communication;single-organism process;regulation of MAPK cascade;JNK cascade;fibril organization;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;regulation of protein modification process;biological adhesion;macromolecule metabolic process;triglyceride metabolic process;regulation of stress-activated protein kinase signaling cascade;cellular process;regulation of stress-activated MAPK cascade;actin cytoskeleton organization;multicellular organismal macromolecule metabolic process;cellular lipid metabolic process;regulation of cellular protein metabolic process;organic acid metabolic process;regulation of response to stress;single organismal cell-cell adhesion;macromolecular complex subunit organization;regulation of cellular metabolic process;carboxylic acid metabolic process;multicellular organismal process;regulation of JUN kinase activity;protein complex subunit organization;phosphate-containing compound metabolic process;organic substance metabolic process;extracellular structure organization;protein phosphorylation;actin filament-based process;cellular protein modification process;regulation of phosphorus metabolic process;stress-activated MAPK cascade;single-organism cellular process;cell adhesion;cell communication;organelle organization;primary metabolic process;cytoskeleton organization;cellular metabolic process;multicellular organism metabolic process;single-organism organelle organization;cellular component biogenesis;phosphorus metabolic process;regulation of protein phosphorylation; 6;4;3;3;5;4;2;3;7;4;5;4;4;7;7;5;5;7;3;3;4;6;5;4;4;4;3;6;7;5;8;2;5;4;6;3;2;4;3;3;4;4;4;3;3;6;5;1;2;5;2;4;5;5;5;5;6;6;5;7;2;3;4;2;6;7;6;5;5;6;2;4;7;5;2;6;5;5;4;5;4;4;4;4;4;6;2;8;5;5;3;4;7;4;6;5;6;3;3;4;4;3;5;3;4;4;3;4;7; GO:0031982;GO:0043230;GO:0044421;GO:0043227;GO:0031012;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0043226;GO:0005576;GO:1903561;GO:0005615;GO:0005575;GO:0005578; vesicle;extracellular organelle;extracellular region part;membrane-bounded organelle;extracellular matrix;cell part;cell;intracellular;extracellular exosome;organelle;extracellular region;extracellular vesicle;extracellular space;cellular_component;proteinaceous extracellular matrix; 4;3;2;3;2;2;2;3;4;2;2;3;3;1;3; GO:0050839;GO:0097367;GO:0003674;GO:0005488;GO:0043168;GO:0005539;GO:1901681;GO:0043167;GO:0032403;GO:0008201;GO:0005515;GO:0044877;GO:0005102;GO:0005178; cell adhesion molecule binding;carbohydrate derivative binding;molecular_function;binding;anion binding;glycosaminoglycan binding;sulfur compound binding;ion binding;protein complex binding;heparin binding;protein binding;macromolecular complex binding;receptor binding;integrin binding; 4;3;1;2;4;4;3;3;4;4;3;3;4;5; K06252 map04151;map04510;map04512;map05206; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;MicroRNAs in cancer; IPR014716;IPR013783;IPR013111;IPR003961;IPR014715;IPR000742;IPR020837;IPR013032;IPR002181;IPR033081; Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Immunoglobulin-like fold;EGF-like domain, extracellular;Fibronectin type III;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;EGF-like domain;Fibrinogen, conserved site;EGF-like, conserved site;Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Tenascin-X; extracellular Hs20544189_1 5926.0 TW [T] Signal transduction mechanisms;[W] Extracellular structures; P68363 Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1 - [TBA1B_HUMAN] 1.112 1.183 0.706 1.096 1.072 1.302 0.939983094 0.555070498 1.02238806 0.773691804 0.596787828 0.013776492 1.214552239 0.426707448 GO:1902589;GO:0070887;GO:0044699;GO:0051716;GO:0071353;GO:0016043;GO:0071310;GO:0071840;GO:0007010;GO:0034097;GO:0009987;GO:0000226;GO:0008150;GO:0042221;GO:0010033;GO:0006996;GO:0007017;GO:0071345;GO:0050896;GO:0070670;GO:0044763; single-organism organelle organization;cellular response to chemical stimulus;single-organism process;cellular response to stimulus;cellular response to interleukin-4;cellular component organization;cellular response to organic substance;cellular component organization or biogenesis;cytoskeleton organization;response to cytokine;cellular process;microtubule cytoskeleton organization;biological_process;response to chemical;response to organic substance;organelle organization;microtubule-based process;cellular response to cytokine stimulus;response to stimulus;response to interleukin-4;single-organism cellular process; 4;4;2;3;7;3;5;2;5;5;2;5;1;3;4;4;4;6;2;6;3; GO:0099512;GO:0099513;GO:0044444;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0005856;GO:0044446;GO:0070062;GO:0043209;GO:0005874;GO:0044430;GO:0015630;GO:0005881;GO:1903561;GO:0031982;GO:0043230;GO:0043232;GO:0044464;GO:0005623;GO:0005737;GO:0005575;GO:0005576;GO:0044424;GO:0044421;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;cytoplasmic part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;cytoskeleton;intracellular organelle part;extracellular exosome;myelin sheath;microtubule;cytoskeletal part;microtubule cytoskeleton;cytoplasmic microtubule;extracellular vesicle;vesicle;extracellular organelle;intracellular non-membrane-bounded organelle;cell part;cell;cytoplasm;cellular_component;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;4;3;3;3;3;2;5;3;4;3;4;4;6;5;3;4;3;4;2;2;4;1;2;3;2;2; GO:0043168;GO:0005200;GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0097367;GO:0032550;GO:0001883;GO:0001882;GO:0019001;GO:0005198;GO:0032555;GO:0032561;GO:0032553;GO:0032549;GO:0017076;GO:0003725;GO:0003676;GO:0005525;GO:0016787;GO:0000166;GO:0003924;GO:0017111;GO:1901265;GO:0003824;GO:0036094;GO:0016818;GO:0043167;GO:0097159;GO:0016817;GO:0016462;GO:0003723; anion binding;structural constituent of cytoskeleton;purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;carbohydrate derivative binding;purine ribonucleoside binding;purine nucleoside binding;nucleoside binding;guanyl nucleotide binding;structural molecule activity;purine ribonucleotide binding;guanyl ribonucleotide binding;ribonucleotide binding;ribonucleoside binding;purine nucleotide binding;double-stranded RNA binding;nucleic acid binding;GTP binding;hydrolase activity;nucleotide binding;GTPase activity;nucleoside-triphosphatase activity;nucleoside phosphate binding;catalytic activity;small molecule binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;ion binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;RNA binding; 4;3;5;3;1;2;3;6;5;4;6;2;5;6;4;5;5;6;4;6;3;4;8;7;4;2;3;5;3;3;4;6;5; K07374 map04145;map04210;map04540;map05130; Phagosome;Apoptosis;Gap junction;Pathogenic Escherichia coli infection; IPR008280;IPR000217;IPR018316;IPR002452;IPR017975;IPR003008; Tubulin/FtsZ, C-terminal;Tubulin;Tubulin/FtsZ, 2-layer sandwich domain;Alpha tubulin;Tubulin, conserved site;Tubulin/FtsZ, GTPase domain; cytoskeleton Hs17986283 941.0 Z [Z] Cytoskeleton; Q9H0E7 Ubiquitin carboxyl-terminal hydrolase 44 OS=Homo sapiens OX=9606 GN=USP44 PE=1 SV=2 - [UBP44_HUMAN] 1.08 0.934 1.035 1.162 0.952 1.157 1.156316916 nan 1.220588235 nan 1.108137045 nan 1.215336134 nan GO:0051348;GO:0080090;GO:0019222;GO:0032435;GO:0044257;GO:0010965;GO:0071840;GO:0045786;GO:0032434;GO:0070647;GO:0070646;GO:0032446;GO:1901799;GO:0044092;GO:0048519;GO:0007088;GO:0060255;GO:0030162;GO:0030163;GO:1902099;GO:0019538;GO:0010639;GO:0051352;GO:0051783;GO:0051782;GO:0051784;GO:0044784;GO:0045841;GO:0009894;GO:0009895;GO:0009892;GO:0090266;GO:0031399;GO:2000816;GO:0007067;GO:0050789;GO:0031577;GO:1901575;GO:0044265;GO:0044260;GO:0016567;GO:1903363;GO:0016043;GO:0043086;GO:0065007;GO:0044699;GO:0061136;GO:0065009;GO:0016579;GO:0071174;GO:0071173;GO:0050790;GO:0031397;GO:0050794;GO:1901987;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0010605;GO:1901988;GO:0051444;GO:0051603;GO:0031400;GO:0010498;GO:0051338;GO:0006511;GO:1903051;GO:1901976;GO:2001251;GO:0033044;GO:0033045;GO:0033046;GO:0033047;GO:0033043;GO:0051246;GO:0033048;GO:0051129;GO:0051128;GO:0044248;GO:0042176;GO:0042177;GO:1901991;GO:1901990;GO:0007059;GO:0007049;GO:0051248;GO:0043161;GO:0010564;GO:1903320;GO:1903321;GO:0000280;GO:0031396;GO:0006508;GO:0090231;GO:0031330;GO:1903050;GO:0009987;GO:0019941;GO:0045839;GO:0051985;GO:0051983;GO:0032269;GO:0032268;GO:0000819;GO:0098813;GO:0010948;GO:0043170;GO:0030071;GO:0045861;GO:0031329;GO:0031324;GO:0031323;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0051438;GO:0051306;GO:0043632;GO:0051304;GO:0051302;GO:0051301;GO:0071704;GO:1904666;GO:1904667;GO:0045930;GO:0000278;GO:1903362;GO:0044267;GO:1903504;GO:0007346;GO:0006464;GO:0051340;GO:0044763;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0000070;GO:0051276;GO:0000075;GO:0051726;GO:0044237;GO:1902589;GO:0048285;GO:1902100;GO:0007094;GO:0007091;GO:0048523;GO:0007093; negative regulation of transferase activity;regulation of primary metabolic process;regulation of metabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;cellular protein catabolic process;regulation of mitotic sister chromatid separation;cellular component organization or biogenesis;negative regulation of cell cycle;regulation of proteasomal ubiquitin-dependent protein catabolic process;protein modification by small protein conjugation or removal;protein modification by small protein removal;protein modification by small protein conjugation;negative regulation of proteasomal protein catabolic process;negative regulation of molecular function;negative regulation of biological process;regulation of mitotic nuclear division;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;regulation of metaphase/anaphase transition of cell cycle;protein metabolic process;negative regulation of organelle organization;negative regulation of ligase activity;regulation of nuclear division;negative regulation of cell division;negative regulation of nuclear division;metaphase/anaphase transition of cell cycle;negative regulation of mitotic metaphase/anaphase transition;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;regulation of mitotic cell cycle spindle assembly checkpoint;regulation of protein modification process;negative regulation of mitotic sister chromatid separation;mitotic nuclear division;regulation of biological process;spindle checkpoint;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;protein ubiquitination;negative regulation of cellular protein catabolic process;cellular component organization;negative regulation of catalytic activity;biological regulation;single-organism process;regulation of proteasomal protein catabolic process;regulation of molecular function;protein deubiquitination;mitotic spindle checkpoint;spindle assembly checkpoint;regulation of catalytic activity;negative regulation of protein ubiquitination;regulation of cellular process;regulation of cell cycle phase transition;macromolecule modification;protein modification process;biological_process;metabolic process;negative regulation of macromolecule metabolic process;negative regulation of cell cycle phase transition;negative regulation of ubiquitin-protein transferase activity;proteolysis involved in cellular protein catabolic process;negative regulation of protein modification process;proteasomal protein catabolic process;regulation of transferase activity;ubiquitin-dependent protein catabolic process;negative regulation of proteolysis involved in cellular protein catabolic process;regulation of cell cycle checkpoint;negative regulation of chromosome organization;regulation of chromosome organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;regulation of organelle organization;regulation of protein metabolic process;negative regulation of mitotic sister chromatid segregation;negative regulation of cellular component organization;regulation of cellular component organization;cellular catabolic process;regulation of protein catabolic process;negative regulation of protein catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;chromosome segregation;cell cycle;negative regulation of protein metabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of cell cycle process;regulation of protein modification by small protein conjugation or removal;negative regulation of protein modification by small protein conjugation or removal;nuclear division;regulation of protein ubiquitination;proteolysis;regulation of spindle checkpoint;negative regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;negative regulation of mitotic nuclear division;negative regulation of chromosome segregation;regulation of chromosome segregation;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;sister chromatid segregation;nuclear chromosome segregation;negative regulation of cell cycle process;macromolecule metabolic process;regulation of mitotic metaphase/anaphase transition;negative regulation of proteolysis;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;regulation of ubiquitin-protein transferase activity;mitotic sister chromatid separation;modification-dependent macromolecule catabolic process;chromosome separation;regulation of cell division;cell division;organic substance metabolic process;regulation of ubiquitin protein ligase activity;negative regulation of ubiquitin protein ligase activity;negative regulation of mitotic cell cycle;mitotic cell cycle;regulation of cellular protein catabolic process;cellular protein metabolic process;regulation of mitotic spindle checkpoint;regulation of mitotic cell cycle;cellular protein modification process;regulation of ligase activity;single-organism cellular process;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;mitotic sister chromatid segregation;chromosome organization;cell cycle checkpoint;regulation of cell cycle;cellular metabolic process;single-organism organelle organization;organelle fission;negative regulation of metaphase/anaphase transition of cell cycle;mitotic spindle assembly checkpoint;metaphase/anaphase transition of mitotic cell cycle;negative regulation of cellular process;mitotic cell cycle checkpoint; 6;4;3;8;6;7;2;4;8;7;6;8;7;4;2;6;4;6;5;6;4;5;6;5;4;5;6;7;4;4;3;7;6;7;5;2;6;4;5;4;9;6;3;5;2;2;7;3;7;6;7;4;8;3;6;5;5;1;2;4;6;7;6;6;6;5;8;7;6;6;6;5;5;6;5;5;6;4;4;4;5;5;6;6;4;4;5;7;5;7;7;6;8;5;7;5;7;2;7;6;4;4;5;5;5;5;5;4;7;6;5;4;4;5;5;6;4;6;6;6;5;4;4;3;7;8;5;5;6;5;7;5;6;5;3;3;5;4;3;6;5;5;4;3;4;5;7;6;6;3;6; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0005856;GO:0044446;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0015630;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;cytoskeleton;intracellular organelle part;nucleolus;nucleus;cell part;cell;organelle;microtubule cytoskeleton;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;2;3;3;3;3;5;3;5;5;2;2;2;6;1;4; GO:0046914;GO:0008270;GO:0003674;GO:0016787;GO:0036459;GO:0003824;GO:0101005;GO:0046872;GO:0008233;GO:0008234;GO:0043169;GO:0019783;GO:0043167;GO:0005488;GO:0004843;GO:0070011; transition metal ion binding;zinc ion binding;molecular_function;hydrolase activity;thiol-dependent ubiquitinyl hydrolase activity;catalytic activity;ubiquitinyl hydrolase activity;metal ion binding;peptidase activity;cysteine-type peptidase activity;cation binding;ubiquitin-like protein-specific protease activity;ion binding;binding;thiol-dependent ubiquitin-specific protease activity;peptidase activity, acting on L-amino acid peptides; 6;7;1;3;5;2;4;5;4;6;4;7;3;2;6;5; K11834 IPR001607;IPR028889;IPR013083;IPR001394;IPR018200; Zinc finger, UBP-type;Ubiquitin specific protease domain;Zinc finger, RING/FYVE/PHD-type;Peptidase C19, ubiquitin carboxyl-terminal hydrolase;Ubiquitin specific protease, conserved site; nucleus Hs14149817 1488.0 O [O] Posttranslational modification, protein turnover, chaperones; Q7Z460 CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1 - [CLAP1_HUMAN] 1.138 1.161 1.017 0.817 1.075 0.776 0.980189492 0.817552401 0.76 0.022210453 0.875968992 0.07691983 0.721860465 0.04965386 GO:0051046;GO:0051047;GO:0051049;GO:0006903;GO:0051656;GO:0051650;GO:0051653;GO:0051716;GO:0014031;GO:0051497;GO:0051495;GO:0051494;GO:0051493;GO:0051492;GO:0090162;GO:0033043;GO:0048468;GO:0031109;GO:0097485;GO:0010634;GO:0010631;GO:0009605;GO:0010638;GO:0010639;GO:1903391;GO:0031175;GO:0035556;GO:0050789;GO:0000904;GO:0000902;GO:0006887;GO:0051225;GO:0043149;GO:0007051;GO:0007052;GO:0032956;GO:0048812;GO:0051129;GO:0051128;GO:0043244;GO:0043241;GO:0043242;GO:0030953;GO:2001197;GO:0000280;GO:0060284;GO:1902850;GO:0010632;GO:0051017;GO:0007409;GO:0010172;GO:0010171;GO:0034329;GO:0044319;GO:0010715;GO:0030038;GO:0045921;GO:0031032;GO:0060341;GO:0030030;GO:0030036;GO:0061041;GO:0022402;GO:0061045;GO:0007275;GO:0051301;GO:0043062;GO:0048598;GO:0090091;GO:0000278;GO:0006461;GO:0044767;GO:0044765;GO:0044763;GO:0051293;GO:0060485;GO:0040011;GO:0051272;GO:0051271;GO:0051270;GO:0048858;GO:0040017;GO:0040019;GO:0048856;GO:0002011;GO:0001837;GO:2000026;GO:0048523;GO:0048522;GO:0000086;GO:0007160;GO:0007163;GO:0007165;GO:0010256;GO:1903689;GO:0006935;GO:0051050;GO:0044699;GO:0050793;GO:0009888;GO:0050794;GO:0051239;GO:0051234;GO:0010717;GO:0050896;GO:2000145;GO:2000147;GO:2000146;GO:0032102;GO:0070271;GO:0007045;GO:0007044;GO:1903530;GO:1903532;GO:0032886;GO:0007049;GO:0051240;GO:0051179;GO:0010769;GO:1902578;GO:0051641;GO:1903034;GO:1903035;GO:0010458;GO:0040013;GO:0040012;GO:0090132;GO:0090130;GO:0007030;GO:0070831;GO:0071711;GO:0048731;GO:0034333;GO:0034332;GO:0034330;GO:0034622;GO:0045216;GO:0030029;GO:0010810;GO:0031122;GO:0022411;GO:0042221;GO:0022008;GO:0007264;GO:0043623;GO:0006996;GO:2000736;GO:0048585;GO:0048583;GO:0071840;GO:0048863;GO:0048864;GO:0048869;GO:0048513;GO:0048518;GO:0048519;GO:0048762;GO:0031589;GO:1901888;GO:1901880;GO:0007155;GO:0044700;GO:0016192;GO:0044707;GO:0070507;GO:0022604;GO:0022607;GO:0022603;GO:0006928;GO:0051674;GO:0090109;GO:0016477;GO:0048646;GO:1904259;GO:0061564;GO:0006810;GO:0006950;GO:0046903;GO:0001578;GO:0080134;GO:0085029;GO:0007369;GO:0030155;GO:0030154;GO:0010927;GO:0030010;GO:1901201;GO:1901203;GO:0043933;GO:0032271;GO:0032273;GO:0017157;GO:0032502;GO:0032501;GO:1903053;GO:0032970;GO:0031334;GO:0060627;GO:0051294;GO:0032879;GO:0051258;GO:0090504;GO:0090505;GO:0001952;GO:0010470;GO:0044839;GO:0048041;GO:0007020;GO:0032984;GO:0007026;GO:0032989;GO:0032101;GO:0048729;GO:0030336;GO:0030335;GO:0030334;GO:0051648;GO:0051649;GO:0070925;GO:1902589;GO:1902580;GO:0031110;GO:0031111;GO:0031112;GO:0031113;GO:0031114;GO:0031116;GO:0051893;GO:0032231;GO:0032232;GO:0042330;GO:0009611;GO:0045995;GO:0048870;GO:0030198;GO:0048667;GO:1901879;GO:0032940;GO:0000226;GO:0035313;GO:0007067;GO:0030182;GO:0016043;GO:0065003;GO:0065007;GO:0051130;GO:0042060;GO:0008150;GO:0043254;GO:0061572;GO:1904261;GO:0009790;GO:0023052;GO:0007411;GO:0001667;GO:0009653;GO:0043624;GO:0046785;GO:0022610;GO:0022617;GO:0031023;GO:0060429;GO:0045595;GO:0007010;GO:0051093;GO:0051094;GO:0009987;GO:1903690;GO:1903047;GO:0044770;GO:0044772;GO:0090307;GO:0002009;GO:0040001;GO:0071822;GO:0051261;GO:0044085;GO:0048666;GO:0034453;GO:0007154;GO:1903055;GO:0007015;GO:0048699;GO:0007017;GO:0032990;GO:0007399;GO:0007019;GO:0044087;GO:0048285;GO:0051640;GO:0044089; regulation of secretion;positive regulation of secretion;regulation of transport;vesicle targeting;establishment of organelle localization;establishment of vesicle localization;spindle localization;cellular response to stimulus;mesenchymal cell development;negative regulation of stress fiber assembly;positive regulation of cytoskeleton organization;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;regulation of stress fiber assembly;establishment of epithelial cell polarity;regulation of organelle organization;cell development;microtubule polymerization or depolymerization;neuron projection guidance;positive regulation of epithelial cell migration;epithelial cell migration;response to external stimulus;positive regulation of organelle organization;negative regulation of organelle organization;regulation of adherens junction organization;neuron projection development;intracellular signal transduction;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;exocytosis;spindle assembly;stress fiber assembly;spindle organization;mitotic spindle organization;regulation of actin cytoskeleton organization;neuron projection morphogenesis;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein complex disassembly;protein complex disassembly;negative regulation of protein complex disassembly;astral microtubule organization;basement membrane assembly involved in embryonic body morphogenesis;nuclear division;regulation of cell development;microtubule cytoskeleton organization involved in mitosis;regulation of epithelial cell migration;actin filament bundle assembly;axonogenesis;embryonic body morphogenesis;body morphogenesis;cell junction assembly;wound healing, spreading of cells;regulation of extracellular matrix disassembly;contractile actin filament bundle assembly;positive regulation of exocytosis;actomyosin structure organization;regulation of cellular localization;cell projection organization;actin cytoskeleton organization;regulation of wound healing;cell cycle process;negative regulation of wound healing;multicellular organism development;cell division;extracellular structure organization;embryonic morphogenesis;positive regulation of extracellular matrix disassembly;mitotic cell cycle;protein complex assembly;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of spindle localization;mesenchyme development;locomotion;positive regulation of cellular component movement;negative regulation of cellular component movement;regulation of cellular component movement;cell projection morphogenesis;positive regulation of locomotion;positive regulation of embryonic development;anatomical structure development;morphogenesis of an epithelial sheet;epithelial to mesenchymal transition;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process;G2/M transition of mitotic cell cycle;cell-matrix adhesion;establishment or maintenance of cell polarity;signal transduction;endomembrane system organization;regulation of wound healing, spreading of epidermal cells;chemotaxis;positive regulation of transport;single-organism process;regulation of developmental process;tissue development;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of epithelial to mesenchymal transition;response to stimulus;regulation of cell motility;positive regulation of cell motility;negative regulation of cell motility;negative regulation of response to external stimulus;protein complex biogenesis;cell-substrate adherens junction assembly;cell-substrate junction assembly;regulation of secretion by cell;positive regulation of secretion by cell;regulation of microtubule-based process;cell cycle;positive regulation of multicellular organismal process;localization;regulation of cell morphogenesis involved in differentiation;single-organism localization;cellular localization;regulation of response to wounding;negative regulation of response to wounding;exit from mitosis;negative regulation of locomotion;regulation of locomotion;epithelium migration;tissue migration;Golgi organization;basement membrane assembly;basement membrane organization;system development;adherens junction assembly;adherens junction organization;cell junction organization;cellular macromolecular complex assembly;cell-cell junction organization;actin filament-based process;regulation of cell-substrate adhesion;cytoplasmic microtubule organization;cellular component disassembly;response to chemical;neurogenesis;small GTPase mediated signal transduction;cellular protein complex assembly;organelle organization;regulation of stem cell differentiation;negative regulation of response to stimulus;regulation of response to stimulus;cellular component organization or biogenesis;stem cell differentiation;stem cell development;cellular developmental process;animal organ development;positive regulation of biological process;negative regulation of biological process;mesenchymal cell differentiation;cell-substrate adhesion;regulation of cell junction assembly;negative regulation of protein depolymerization;cell adhesion;single organism signaling;vesicle-mediated transport;single-multicellular organism process;regulation of microtubule cytoskeleton organization;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;regulation of cell-substrate junction assembly;cell migration;anatomical structure formation involved in morphogenesis;regulation of basement membrane assembly involved in embryonic body morphogenesis;axon development;transport;response to stress;secretion;microtubule bundle formation;regulation of response to stress;extracellular matrix assembly;gastrulation;regulation of cell adhesion;cell differentiation;cellular component assembly involved in morphogenesis;establishment of cell polarity;regulation of extracellular matrix assembly;positive regulation of extracellular matrix assembly;macromolecular complex subunit organization;regulation of protein polymerization;positive regulation of protein polymerization;regulation of exocytosis;developmental process;multicellular organismal process;regulation of extracellular matrix organization;regulation of actin filament-based process;positive regulation of protein complex assembly;regulation of vesicle-mediated transport;establishment of spindle orientation;regulation of localization;protein polymerization;epiboly;epiboly involved in wound healing;regulation of cell-matrix adhesion;regulation of gastrulation;cell cycle G2/M phase transition;focal adhesion assembly;microtubule nucleation;macromolecular complex disassembly;negative regulation of microtubule depolymerization;cellular component morphogenesis;regulation of response to external stimulus;tissue morphogenesis;negative regulation of cell migration;positive regulation of cell migration;regulation of cell migration;vesicle localization;establishment of localization in cell;organelle assembly;single-organism organelle organization;single-organism cellular localization;regulation of microtubule polymerization or depolymerization;negative regulation of microtubule polymerization or depolymerization;positive regulation of microtubule polymerization or depolymerization;regulation of microtubule polymerization;regulation of microtubule depolymerization;positive regulation of microtubule polymerization;regulation of focal adhesion assembly;regulation of actin filament bundle assembly;negative regulation of actin filament bundle assembly;taxis;response to wounding;regulation of embryonic development;cell motility;extracellular matrix organization;cell morphogenesis involved in neuron differentiation;regulation of protein depolymerization;secretion by cell;microtubule cytoskeleton organization;wound healing, spreading of epidermal cells;mitotic nuclear division;neuron differentiation;cellular component organization;macromolecular complex assembly;biological regulation;positive regulation of cellular component organization;wound healing;biological_process;regulation of protein complex assembly;actin filament bundle organization;positive regulation of basement membrane assembly involved in embryonic body morphogenesis;embryo development;signaling;axon guidance;ameboidal-type cell migration;anatomical structure morphogenesis;cellular protein complex disassembly;microtubule polymerization;biological adhesion;extracellular matrix disassembly;microtubule organizing center organization;epithelium development;regulation of cell differentiation;cytoskeleton organization;negative regulation of developmental process;positive regulation of developmental process;cellular process;negative regulation of wound healing, spreading of epidermal cells;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;mitotic spindle assembly;morphogenesis of an epithelium;establishment of mitotic spindle localization;protein complex subunit organization;protein depolymerization;cellular component biogenesis;neuron development;microtubule anchoring;cell communication;positive regulation of extracellular matrix organization;actin filament organization;generation of neurons;microtubule-based process;cell part morphogenesis;nervous system development;microtubule depolymerization;regulation of cellular component biogenesis;organelle fission;organelle localization;positive regulation of cellular component biogenesis; 5;4;4;4;4;5;5;3;6;6;6;6;6;5;6;5;4;6;5;4;6;3;5;5;5;5;5;2;5;5;5;6;7;5;6;5;6;4;4;5;6;5;6;5;6;5;6;4;5;7;5;4;5;5;6;6;5;6;4;4;5;6;4;5;4;4;4;4;6;5;5;3;4;3;5;5;2;4;4;4;5;3;4;3;6;6;4;3;3;6;5;4;4;4;5;4;3;2;3;4;3;3;3;5;2;4;4;4;4;4;7;6;5;4;4;4;3;2;6;3;3;5;4;6;3;3;5;4;5;6;6;4;6;6;4;6;5;4;5;6;4;3;6;6;6;4;5;3;3;2;6;5;4;4;2;2;6;4;4;6;3;3;5;3;5;5;4;4;4;3;5;4;3;5;6;4;3;5;6;4;5;5;4;5;4;5;4;4;4;5;5;5;2;2;5;4;4;4;6;3;7;7;6;6;5;6;6;6;5;7;4;4;4;5;5;5;5;4;5;4;4;6;7;7;6;7;6;6;4;5;3;4;5;3;5;6;6;4;5;6;5;6;3;5;2;4;5;1;4;7;5;5;2;6;5;3;7;7;2;5;5;5;4;5;3;3;2;4;5;5;6;6;5;6;5;8;3;5;6;4;5;6;7;4;5;5;7;3;5;4;3; GO:0099512;GO:0099513;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0005876;GO:0045178;GO:0099738;GO:0044464;GO:1903561;GO:0071944;GO:0070062;GO:0045180;GO:0031592;GO:0016020;GO:0000793;GO:0043234;GO:0043230;GO:0043231;GO:0043232;GO:0005829;GO:0005828;GO:0044430;GO:0043228;GO:0030981;GO:0005819;GO:0005813;GO:0005815;GO:0035371;GO:0043229;GO:0043227;GO:0043226;GO:0005856;GO:0005938;GO:0044446;GO:0044444;GO:0044448;GO:0012505;GO:0005737;GO:0099568;GO:0000779;GO:0000775;GO:0000776;GO:0000777;GO:0031982;GO:0005794;GO:1990752;GO:0005874;GO:0098687;GO:0030863;GO:0044450;GO:0005623;GO:0005622;GO:0005694;GO:0015630;GO:0005881;GO:0032991;GO:0005575;GO:0005576; supramolecular fiber;polymeric cytoskeletal fiber;intracellular part;chromosomal part;extracellular region part;organelle part;spindle microtubule;basal part of cell;cell cortex region;cell part;extracellular vesicle;cell periphery;extracellular exosome;basal cortex;centrosomal corona;membrane;condensed chromosome;protein complex;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;kinetochore microtubule;cytoskeletal part;non-membrane-bounded organelle;cortical microtubule cytoskeleton;spindle;centrosome;microtubule organizing center;microtubule plus-end;intracellular organelle;membrane-bounded organelle;organelle;cytoskeleton;cell cortex;intracellular organelle part;cytoplasmic part;cell cortex part;endomembrane system;cytoplasm;cytoplasmic region;condensed chromosome, centromeric region;chromosome, centromeric region;kinetochore;condensed chromosome kinetochore;vesicle;Golgi apparatus;microtubule end;microtubule;chromosomal region;cortical cytoskeleton;microtubule organizing center part;cell;intracellular;chromosome;microtubule cytoskeleton;cytoplasmic microtubule;macromolecular complex;cellular_component;extracellular region; 2;3;3;4;2;2;5;3;5;2;3;3;4;4;6;2;6;3;3;4;4;5;6;4;3;5;5;5;5;5;3;3;2;5;4;3;4;5;3;4;5;7;6;4;5;4;4;5;4;5;6;5;2;3;5;6;5;2;1;2; GO:0005488;GO:0051010;GO:0003674;GO:0002162;GO:0001948;GO:0032403;GO:0005515;GO:0044877;GO:0008092;GO:0097367;GO:0008017;GO:0015631;GO:0043515; binding;microtubule plus-end binding;molecular_function;dystroglycan binding;glycoprotein binding;protein complex binding;protein binding;macromolecular complex binding;cytoskeletal protein binding;carbohydrate derivative binding;microtubule binding;tubulin binding;kinetochore binding; 2;6;1;5;4;4;3;3;4;3;5;5;5; K16578 IPR021133;IPR016024;IPR034085;IPR028399;IPR011989;IPR024395; HEAT, type 2;Armadillo-type fold;TOG domain;CLIP-associating protein 1;Armadillo-like helical;CLASP N-terminal domain; nucleus Hs22041059 1182.0 R [R] General function prediction only; Q8N6Y2 Leucine-rich repeat-containing protein 17 OS=Homo sapiens OX=9606 GN=LRRC17 PE=2 SV=1 - [LRC17_HUMAN] 0.889 1.028 0.369 2.687 0.679 1.023 0.864785992 nan 3.957290133 nan 0.358949416 nan 1.506627393 nan GO:0030099;GO:0030154;GO:0060348;GO:0001501;GO:0001503;GO:0030316;GO:0050789;GO:0044699;GO:0002761;GO:0002762;GO:0048869;GO:0051241;GO:0045638;GO:0002573;GO:0048513;GO:0002682;GO:0002683;GO:0048539;GO:0065007;GO:0048534;GO:0032502;GO:0032501;GO:0050793;GO:0009987;GO:0048731;GO:0009888;GO:0050794;GO:0044767;GO:0045596;GO:0045595;GO:0008150;GO:0051239;GO:0048519;GO:1903706;GO:1903707;GO:0002521;GO:0002520;GO:0051093;GO:0044707;GO:0048856;GO:0030097;GO:0002376;GO:1902106;GO:1902105;GO:2000026;GO:0045670;GO:0045671;GO:0007275;GO:0044763;GO:0045637;GO:0048523; myeloid cell differentiation;cell differentiation;bone development;skeletal system development;ossification;osteoclast differentiation;regulation of biological process;single-organism process;regulation of myeloid leukocyte differentiation;negative regulation of myeloid leukocyte differentiation;cellular developmental process;negative regulation of multicellular organismal process;negative regulation of myeloid cell differentiation;myeloid leukocyte differentiation;animal organ development;regulation of immune system process;negative regulation of immune system process;bone marrow development;biological regulation;hematopoietic or lymphoid organ development;developmental process;multicellular organismal process;regulation of developmental process;cellular process;system development;tissue development;regulation of cellular process;single-organism developmental process;negative regulation of cell differentiation;regulation of cell differentiation;biological_process;regulation of multicellular organismal process;negative regulation of biological process;regulation of hemopoiesis;negative regulation of hemopoiesis;leukocyte differentiation;immune system development;negative regulation of developmental process;single-multicellular organism process;anatomical structure development;hemopoiesis;immune system process;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;regulation of osteoclast differentiation;negative regulation of osteoclast differentiation;multicellular organism development;single-organism cellular process;regulation of myeloid cell differentiation;negative regulation of cellular process; 6;5;4;5;4;8;2;2;6;6;4;3;5;7;4;3;3;5;2;4;2;2;3;2;4;4;3;3;4;4;1;3;2;4;4;6;3;3;3;3;5;2;5;5;4;7;7;4;3;5;3; GO:0044421;GO:0005575;GO:0005615;GO:0005576; extracellular region part;cellular_component;extracellular space;extracellular region; 2;1;3;2; IPR003591;IPR032675;IPR000483;IPR001611; Leucine-rich repeat, typical subtype;Leucine-rich repeat domain, L domain-like;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat; endoplasmic reticulum Hs5031971 632.0 R [R] General function prediction only; Q96N64 PWWP domain-containing protein 2A OS=Homo sapiens OX=9606 GN=PWWP2A PE=1 SV=2 - [PWP2A_HUMAN] 0.985 0.749 1.59 0.625 0.867 1.599 1.315086782 nan 0.720876586 nan 2.122830441 nan 1.844290657 nan IPR000313; PWWP domain; nucleus O75995 SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2 - [SASH3_HUMAN] 0.316 0.331 3.096 0.692 0.398 0.613 0.954682779 0.005162657 1.738693467 0.026893698 9.35347432 0.000174281 1.540201005 0.139448356 GO:0032623;GO:0034112;GO:0048589;GO:0060249;GO:0046637;GO:0046635;GO:0048584;GO:0048583;GO:0046632;GO:0046631;GO:0002706;GO:0002705;GO:0002703;GO:0002702;GO:0002700;GO:0002456;GO:0044707;GO:0002709;GO:0002708;GO:0045785;GO:0048869;GO:0034110;GO:0002367;GO:0048513;GO:0032729;GO:0048518;GO:0002682;GO:0042127;GO:0046634;GO:0032653;GO:0030217;GO:0002824;GO:0002822;GO:0042129;GO:0002821;GO:1903708;GO:0046649;GO:0007155;GO:1903706;GO:0071593;GO:0048873;GO:0048872;GO:0048871;GO:0051094;GO:0002376;GO:0002377;GO:0070489;GO:0032733;GO:0032640;GO:0050670;GO:0035265;GO:0032649;GO:0050671;GO:0032943;GO:1903557;GO:1903555;GO:0046651;GO:0050789;GO:0042098;GO:0050793;GO:0002684;GO:0065007;GO:0065008;GO:0002369;GO:0032760;GO:0098602;GO:0030890;GO:0098609;GO:0050794;GO:0001775;GO:0008150;GO:0051239;GO:0006955;GO:0032633;GO:0002521;GO:0002520;GO:0002711;GO:0050896;GO:0002694;GO:0002697;GO:0002696;GO:0043370;GO:0007275;GO:0007159;GO:0002699;GO:0035710;GO:0048639;GO:0048638;GO:0030155;GO:0030154;GO:0030888;GO:0002819;GO:0045580;GO:0002440;GO:0045582;GO:0044699;GO:0045927;GO:0051249;GO:0051240;GO:1903039;GO:0045621;GO:0032673;GO:0022610;GO:0043367;GO:1903037;GO:0008284;GO:0032501;GO:0008283;GO:0046638;GO:0032613;GO:0009987;GO:2000516;GO:0050870;GO:0050871;GO:0045597;GO:0045595;GO:0070486;GO:0042110;GO:0001894;GO:0002639;GO:0050776;GO:0002460;GO:0045321;GO:0051251;GO:0050778;GO:0001816;GO:0001817;GO:0045619;GO:0030098;GO:0032946;GO:0043372;GO:0032663;GO:0001819;GO:0032609;GO:0032502;GO:0016337;GO:0032944;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0050863;GO:0042592;GO:0022407;GO:0002724;GO:0002726;GO:0002720;GO:0022409;GO:1902107;GO:0040007;GO:0040008;GO:0032743;GO:0070661;GO:0070663;GO:0071706;GO:0070665;GO:0048534;GO:0046620;GO:0034109;GO:0046622;GO:0048731;GO:0042100;GO:0042102;GO:0044767;GO:0002449;GO:0044763;GO:2000514;GO:0002718;GO:0002443;GO:0002637;GO:0048856;GO:0030097;GO:0032680;GO:1902105;GO:2000026;GO:0002250;GO:0002252;GO:0032753;GO:0048522; interleukin-2 production;positive regulation of homotypic cell-cell adhesion;developmental growth;anatomical structure homeostasis;regulation of alpha-beta T cell differentiation;positive regulation of alpha-beta T cell activation;positive regulation of response to stimulus;regulation of response to stimulus;alpha-beta T cell differentiation;alpha-beta T cell activation;regulation of lymphocyte mediated immunity;positive regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;positive regulation of production of molecular mediator of immune response;regulation of production of molecular mediator of immune response;T cell mediated immunity;single-multicellular organism process;regulation of T cell mediated immunity;positive regulation of lymphocyte mediated immunity;positive regulation of cell adhesion;cellular developmental process;regulation of homotypic cell-cell adhesion;cytokine production involved in immune response;animal organ development;positive regulation of interferon-gamma production;positive regulation of biological process;regulation of immune system process;regulation of cell proliferation;regulation of alpha-beta T cell activation;regulation of interleukin-10 production;T cell differentiation;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of T cell proliferation;positive regulation of adaptive immune response;positive regulation of hemopoiesis;lymphocyte activation;cell adhesion;regulation of hemopoiesis;lymphocyte aggregation;homeostasis of number of cells within a tissue;homeostasis of number of cells;multicellular organismal homeostasis;positive regulation of developmental process;immune system process;immunoglobulin production;T cell aggregation;positive regulation of interleukin-10 production;tumor necrosis factor production;regulation of lymphocyte proliferation;organ growth;regulation of interferon-gamma production;positive regulation of lymphocyte proliferation;mononuclear cell proliferation;positive regulation of tumor necrosis factor superfamily cytokine production;regulation of tumor necrosis factor superfamily cytokine production;lymphocyte proliferation;regulation of biological process;T cell proliferation;regulation of developmental process;positive regulation of immune system process;biological regulation;regulation of biological quality;T cell cytokine production;positive regulation of tumor necrosis factor production;single organism cell adhesion;positive regulation of B cell proliferation;cell-cell adhesion;regulation of cellular process;cell activation;biological_process;regulation of multicellular organismal process;immune response;interleukin-4 production;leukocyte differentiation;immune system development;positive regulation of T cell mediated immunity;response to stimulus;regulation of leukocyte activation;regulation of immune effector process;positive regulation of leukocyte activation;regulation of CD4-positive, alpha-beta T cell differentiation;multicellular organism development;leukocyte cell-cell adhesion;positive regulation of immune effector process;CD4-positive, alpha-beta T cell activation;positive regulation of developmental growth;regulation of developmental growth;regulation of cell adhesion;cell differentiation;regulation of B cell proliferation;regulation of adaptive immune response;regulation of T cell differentiation;production of molecular mediator of immune response;positive regulation of T cell differentiation;single-organism process;positive regulation of growth;regulation of lymphocyte activation;positive regulation of multicellular organismal process;positive regulation of leukocyte cell-cell adhesion;positive regulation of lymphocyte differentiation;regulation of interleukin-4 production;biological adhesion;CD4-positive, alpha-beta T cell differentiation;regulation of leukocyte cell-cell adhesion;positive regulation of cell proliferation;multicellular organismal process;cell proliferation;positive regulation of alpha-beta T cell differentiation;interleukin-10 production;cellular process;positive regulation of CD4-positive, alpha-beta T cell activation;positive regulation of T cell activation;positive regulation of B cell activation;positive regulation of cell differentiation;regulation of cell differentiation;leukocyte aggregation;T cell activation;tissue homeostasis;positive regulation of immunoglobulin production;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;leukocyte activation;positive regulation of lymphocyte activation;positive regulation of immune response;cytokine production;regulation of cytokine production;regulation of lymphocyte differentiation;lymphocyte differentiation;positive regulation of mononuclear cell proliferation;positive regulation of CD4-positive, alpha-beta T cell differentiation;regulation of interleukin-2 production;positive regulation of cytokine production;interferon-gamma production;developmental process;single organismal cell-cell adhesion;regulation of mononuclear cell proliferation;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;regulation of T cell activation;homeostatic process;regulation of cell-cell adhesion;regulation of T cell cytokine production;positive regulation of T cell cytokine production;positive regulation of cytokine production involved in immune response;positive regulation of cell-cell adhesion;positive regulation of leukocyte differentiation;growth;regulation of growth;positive regulation of interleukin-2 production;leukocyte proliferation;regulation of leukocyte proliferation;tumor necrosis factor superfamily cytokine production;positive regulation of leukocyte proliferation;hematopoietic or lymphoid organ development;regulation of organ growth;homotypic cell-cell adhesion;positive regulation of organ growth;system development;B cell proliferation;positive regulation of T cell proliferation;single-organism developmental process;lymphocyte mediated immunity;single-organism cellular process;regulation of CD4-positive, alpha-beta T cell activation;regulation of cytokine production involved in immune response;leukocyte mediated immunity;regulation of immunoglobulin production;anatomical structure development;hemopoiesis;regulation of tumor necrosis factor production;regulation of leukocyte differentiation;regulation of multicellular organismal development;adaptive immune response;immune effector process;positive regulation of interleukin-4 production;positive regulation of cellular process; 5;6;3;5;8;7;3;3;7;6;6;5;5;4;4;6;3;7;6;4;4;6;4;4;5;2;3;4;7;5;6;6;6;7;5;4;4;3;4;7;6;5;4;3;2;4;4;5;6;6;4;5;6;5;5;5;5;2;6;3;3;2;3;5;6;3;7;4;3;4;1;3;3;5;6;3;7;2;4;4;4;9;4;5;4;7;4;4;4;5;7;5;7;3;7;2;3;5;3;6;6;5;2;8;6;4;2;3;8;5;2;8;6;6;4;4;6;5;5;5;4;5;3;5;4;4;4;6;5;6;9;5;4;5;2;4;6;4;6;4;5;6;4;5;6;6;5;5;5;2;3;5;4;5;5;5;4;4;5;4;4;6;7;3;5;3;8;5;4;5;3;5;6;5;4;4;3;5;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cytoplasm;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;4;2;2;3;2;1; IPR021090;IPR001452;IPR013761;IPR011511;IPR001660; SAM/SH3 domain-containing;SH3 domain;Sterile alpha motif/pointed domain;Variant SH3 domain;Sterile alpha motif domain; nucleus Hs9506363 771.0 R [R] General function prediction only; Q15276 Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2 - [RABE1_HUMAN] 1.005 1.149 0.958 1.121 1.131 0.533 0.874673629 nan 0.991158267 nan 0.833768494 nan 0.471264368 nan GO:0008104;GO:0061025;GO:0061024;GO:0008219;GO:0071840;GO:0016043;GO:0044699;GO:0071702;GO:0033036;GO:0009987;GO:0006810;GO:0045184;GO:0012501;GO:0008150;GO:0051234;GO:0051179;GO:0006897;GO:0016192;GO:0044763;GO:0015031;GO:0006915; protein localization;membrane fusion;membrane organization;cell death;cellular component organization or biogenesis;cellular component organization;single-organism process;organic substance transport;macromolecule localization;cellular process;transport;establishment of protein localization;programmed cell death;biological_process;establishment of localization;localization;endocytosis;vesicle-mediated transport;single-organism cellular process;protein transport;apoptotic process; 4;5;4;4;2;3;2;5;3;2;4;4;5;1;3;2;6;5;3;5;6; GO:0055037;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0031982;GO:0005773;GO:0031410;GO:0031988;GO:0012505;GO:0043231;GO:0030139;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0016023;GO:0044444;GO:0044424;GO:0005769;GO:0005768;GO:0097708; recycling endosome;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;vesicle;vacuole;cytoplasmic vesicle;membrane-bounded vesicle;endomembrane system;intracellular membrane-bounded organelle;endocytic vesicle;cell part;cell;intracellular;cellular_component;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;intracellular part;early endosome;endosome;intracellular vesicle; 5;3;3;2;4;4;5;5;5;3;4;6;2;2;3;1;5;4;3;5;4;4; GO:0005488;GO:0003674;GO:0008047;GO:0098772;GO:0042802;GO:0042803;GO:0030234;GO:0005096;GO:0060589;GO:0030695;GO:0005515;GO:0046983; binding;molecular_function;enzyme activator activity;molecular function regulator;identical protein binding;protein homodimerization activity;enzyme regulator activity;GTPase activator activity;nucleoside-triphosphatase regulator activity;GTPase regulator activity;protein binding;protein dimerization activity; 2;1;4;2;4;5;3;5;4;5;3;4; K12480 map04144; Endocytosis; IPR018514;IPR003914;IPR015390;IPR029880; Rabaptin coiled-coil domain;Rabaptin;Rabaptin, GTPase-Rab5 binding domain;Rabaptin-5; nucleus Hs4759006 1727.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q9NVU0 DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1 - [RPC5_HUMAN] 1.039 0.963 1.213 0.949 0.999 0.895 1.078920042 nan 0.94994995 nan 1.2596054 nan 0.895895896 nan GO:1901362;GO:1901360;GO:0009615;GO:0048518;GO:0006386;GO:0006385;GO:0046483;GO:0006383;GO:0051707;GO:0051704;GO:0009607;GO:0044707;GO:0002376;GO:0019438;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0018130;GO:0006952;GO:0032481;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:0016070;GO:0044271;GO:0051607;GO:0050896;GO:0006950;GO:0051239;GO:0006351;GO:0006353;GO:0043207;GO:0051240;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032501;GO:0009987;GO:0006725;GO:0098542;GO:0001816;GO:0001817;GO:0032479;GO:0001819;GO:0032606;GO:0090304;GO:0006354;GO:0071704;GO:0010467;GO:0009605;GO:0045087;GO:0009058;GO:0009059;GO:0044238;GO:0044237;GO:0002252; organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;response to virus;positive regulation of biological process;termination of RNA polymerase III transcription;transcription elongation from RNA polymerase III promoter;heterocycle metabolic process;transcription from RNA polymerase III promoter;response to other organism;multi-organism process;response to biotic stimulus;single-multicellular organism process;immune system process;aromatic compound biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;heterocycle biosynthetic process;defense response;positive regulation of type I interferon production;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;defense response to virus;response to stimulus;response to stress;regulation of multicellular organismal process;transcription, DNA-templated;DNA-templated transcription, termination;response to external biotic stimulus;positive regulation of multicellular organismal process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;defense response to other organism;cytokine production;regulation of cytokine production;regulation of type I interferon production;positive regulation of cytokine production;type I interferon production;nucleic acid metabolic process;DNA-templated transcription, elongation;organic substance metabolic process;gene expression;response to external stimulus;innate immune response;biosynthetic process;macromolecule biosynthetic process;primary metabolic process;cellular metabolic process;immune effector process; 5;4;4;2;8;8;4;7;3;2;3;3;2;5;3;4;2;7;4;4;2;5;4;5;1;2;3;5;5;5;4;2;3;3;6;7;4;3;6;4;4;5;2;4;2;2;4;4;4;4;5;4;5;5;7;3;5;3;4;3;5;3;3;3; GO:0031974;GO:0030880;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0005666;GO:0044424;GO:0044422;GO:0044464;GO:0043229;GO:0043227;GO:0005654;GO:0055029;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044451;GO:0061695;GO:0000428;GO:0005623;GO:0005622;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;RNA polymerase complex;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;DNA-directed RNA polymerase III complex;intracellular part;organelle part;cell part;intracellular organelle;membrane-bounded organelle;nucleoplasm;nuclear DNA-directed RNA polymerase complex;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nucleoplasm part;transferase complex, transferring phosphorus-containing groups;DNA-directed RNA polymerase complex;cell;intracellular;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;4;5;4;5;3;4;3;5;4;6;3;2;2;3;3;5;5;3;4;4;5;5;6;5;2;3;2;2;1;4; GO:0016740;GO:0034062;GO:0003674;GO:0003824;GO:0016779;GO:0016772;GO:0003899; transferase activity;RNA polymerase activity;molecular_function;catalytic activity;nucleotidyltransferase activity;transferase activity, transferring phosphorus-containing groups;DNA-directed RNA polymerase activity; 3;6;1;2;5;4;7; K14721 map00230;map00240;map03020;map04623;map05169; Purine metabolism;Pyrimidine metabolism;RNA polymerase;Cytosolic DNA-sensing pathway;Epstein-Barr virus infection; IPR006886; DNA-directed RNA polymerase III subunit Rpc5; cytosol, nucleus Hs8922477 1472.0 K [K] Transcription; Q13885 Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1 - [TBB2A_HUMAN] 0.843 1.148 0.356 1.395 1.468 1.735 0.734320557 nan 0.95027248 nan 0.31010453 nan 1.181880109 nan GO:0044699;GO:0009987;GO:0044763;GO:0007017;GO:0008150; single-organism process;cellular process;single-organism cellular process;microtubule-based process;biological_process; 2;2;3;4;1; GO:0099512;GO:0099513;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070062;GO:0005874;GO:0005634;GO:0044430;GO:0015630;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0043232;GO:0005856;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;extracellular exosome;microtubule;nucleus;cytoskeletal part;microtubule cytoskeleton;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytoskeleton;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;3;3;3;2;4;3;4;4;5;4;6;3;4;3;4;4;5;2;2;3;1;2;3;2;2; GO:0043168;GO:0005200;GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0001883;GO:0032550;GO:0000166;GO:0001882;GO:0019001;GO:0005198;GO:0032561;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0016787;GO:0003924;GO:0017111;GO:0036094;GO:0003824;GO:0032555;GO:0016818;GO:0043167;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032553; anion binding;structural constituent of cytoskeleton;purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;purine nucleoside binding;purine ribonucleoside binding;nucleotide binding;nucleoside binding;guanyl nucleotide binding;structural molecule activity;guanyl ribonucleotide binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;hydrolase activity;GTPase activity;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;ion binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;ribonucleotide binding; 4;3;5;3;1;2;5;6;4;4;6;2;6;4;5;5;6;3;8;7;3;2;5;5;3;3;3;4;6;4; K07375 map04145;map04540;map05130; Phagosome;Gap junction;Pathogenic Escherichia coli infection; IPR008280;IPR000217;IPR018316;IPR002453;IPR017975;IPR003008;IPR013838; Tubulin/FtsZ, C-terminal;Tubulin;Tubulin/FtsZ, 2-layer sandwich domain;Beta tubulin;Tubulin, conserved site;Tubulin/FtsZ, GTPase domain;Beta tubulin, autoregulation binding site; cytosol Hs4507729 936.0 Z [Z] Cytoskeleton; P30281 G1/S-specific cyclin-D3 OS=Homo sapiens OX=9606 GN=CCND3 PE=1 SV=2 - [CCND3_HUMAN] 0.577 0.809 2.081 0.636 0.779 1.146 0.713226205 nan 0.816431322 nan 2.572311496 nan 1.471116816 nan GO:0042098;GO:0019220;GO:0080090;GO:0019222;GO:0007165;GO:1904031;GO:0051716;GO:0045787;GO:0044093;GO:0048518;GO:0042325;GO:0060255;GO:0045859;GO:0046649;GO:0044700;GO:0042327;GO:0019538;GO:0002376;GO:1904029;GO:0070489;GO:0009893;GO:0033674;GO:0032943;GO:0046651;GO:0071902;GO:0071900;GO:0044267;GO:0051347;GO:0044260;GO:0043549;GO:0065007;GO:0007049;GO:0065009;GO:0071593;GO:0043085;GO:0098602;GO:0098609;GO:0050790;GO:0050794;GO:0001775;GO:0036211;GO:0008150;GO:0008152;GO:0010604;GO:0050896;GO:0031401;GO:0043412;GO:0051338;GO:0045737;GO:0044763;GO:0010562;GO:0016310;GO:0023052;GO:0044699;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0022610;GO:0043170;GO:0009987;GO:0032268;GO:0045321;GO:0045860;GO:0016337;GO:0031325;GO:0031323;GO:0042110;GO:0051301;GO:0008283;GO:0050789;GO:0070661;GO:0071704;GO:0006468;GO:0045937;GO:0006464;GO:0051174;GO:0007159;GO:0007155;GO:0007154;GO:0070486;GO:0044238;GO:0051726;GO:0000079;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048522; T cell proliferation;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;signal transduction;positive regulation of cyclin-dependent protein kinase activity;cellular response to stimulus;positive regulation of cell cycle;positive regulation of molecular function;positive regulation of biological process;regulation of phosphorylation;regulation of macromolecule metabolic process;regulation of protein kinase activity;lymphocyte activation;single organism signaling;positive regulation of phosphorylation;protein metabolic process;immune system process;regulation of cyclin-dependent protein kinase activity;T cell aggregation;positive regulation of metabolic process;positive regulation of kinase activity;mononuclear cell proliferation;lymphocyte proliferation;positive regulation of protein serine/threonine kinase activity;regulation of protein serine/threonine kinase activity;cellular protein metabolic process;positive regulation of transferase activity;cellular macromolecule metabolic process;regulation of kinase activity;biological regulation;cell cycle;regulation of molecular function;lymphocyte aggregation;positive regulation of catalytic activity;single organism cell adhesion;cell-cell adhesion;regulation of catalytic activity;regulation of cellular process;cell activation;protein modification process;biological_process;metabolic process;positive regulation of macromolecule metabolic process;response to stimulus;positive regulation of protein modification process;macromolecule modification;regulation of transferase activity;positive regulation of cyclin-dependent protein serine/threonine kinase activity;single-organism cellular process;positive regulation of phosphorus metabolic process;phosphorylation;signaling;single-organism process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;biological adhesion;macromolecule metabolic process;cellular process;regulation of cellular protein metabolic process;leukocyte activation;positive regulation of protein kinase activity;single organismal cell-cell adhesion;positive regulation of cellular metabolic process;regulation of cellular metabolic process;T cell activation;cell division;cell proliferation;regulation of biological process;leukocyte proliferation;organic substance metabolic process;protein phosphorylation;positive regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;leukocyte cell-cell adhesion;cell adhesion;cell communication;leukocyte aggregation;primary metabolic process;regulation of cell cycle;regulation of cyclin-dependent protein serine/threonine kinase activity;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;6;4;3;4;6;3;4;4;2;7;4;7;4;3;7;4;2;5;4;3;7;5;5;9;8;5;6;4;6;2;4;3;7;5;3;4;4;3;4;5;1;2;4;2;6;5;5;5;3;5;6;2;2;5;5;5;6;2;4;2;5;3;8;4;4;4;5;4;3;2;4;3;7;6;6;5;5;3;4;6;3;4;6;3;5;4;7;7;3; GO:0031974;GO:0070161;GO:0030054;GO:0030055;GO:0031981;GO:0016020;GO:1902494;GO:1902554;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0000307;GO:0043229;GO:0005924;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005737;GO:1902911;GO:0005634;GO:0061695;GO:0005912;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005925;GO:0005886;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;anchoring junction;cell junction;cell-substrate junction;nuclear lumen;membrane;catalytic complex;serine/threonine protein kinase complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;cyclin-dependent protein kinase holoenzyme complex;intracellular organelle;cell-substrate adherens junction;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasm;protein kinase complex;nucleus;transferase complex, transferring phosphorus-containing groups;adherens junction;cell part;cell;intracellular;cell periphery;focal adhesion;plasma membrane;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;2;3;5;2;4;8;5;3;4;3;4;3;2;4;3;4;3;2;5;3;4;7;5;6;4;2;2;3;3;5;3;2;1;4; GO:0004674;GO:0097472;GO:0016740;GO:0019901;GO:0019900;GO:0003674;GO:0005488;GO:0003824;GO:0016773;GO:0016772;GO:0016301;GO:0019899;GO:0004693;GO:0005515;GO:0004672; protein serine/threonine kinase activity;cyclin-dependent protein kinase activity;transferase activity;protein kinase binding;kinase binding;molecular_function;binding;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;kinase activity;enzyme binding;cyclin-dependent protein serine/threonine kinase activity;protein binding;protein kinase activity; 7;7;3;6;5;1;2;2;5;4;5;4;8;3;6; K10152 map04110;map04115;map04151;map04310;map04390;map04510;map04630;map05162;map05166;map05203; Cell cycle;p53 signaling pathway;PI3K-Akt signaling pathway;Wnt signaling pathway;Hippo signaling pathway;Focal adhesion;Jak-STAT signaling pathway;Measles;HTLV-I infection;Viral carcinogenesis; IPR013763;IPR004367;IPR006671;IPR015451; Cyclin-like;Cyclin, C-terminal domain;Cyclin, N-terminal;Cyclin D; cytosol Hs4502619 597.0 D [D] Cell cycle control, cell division, chromosome partitioning; Q6ZN30 Zinc finger protein basonuclin-2 OS=Homo sapiens OX=9606 GN=BNC2 PE=1 SV=1 - [BNC2_HUMAN] 0.948 0.923 1.297 1.004 0.913 1.054 1.02708559 0.611464496 1.099671413 0.53491424 1.405200433 0.00141976 1.154435926 0.092005068 GO:0080090;GO:0019222;GO:0035265;GO:1901362;GO:1901360;GO:0048589;GO:0098868;GO:0048513;GO:0003416;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0019438;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0018130;GO:0009889;GO:0009888;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0007423;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0051252;GO:0043170;GO:0048731;GO:0031326;GO:0031323;GO:0060021;GO:0090304;GO:0007275;GO:0040007;GO:2000112;GO:0050789;GO:0043586;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0051171;GO:0060485;GO:0044238;GO:0048856;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;organ growth;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;developmental growth;bone growth;animal organ development;endochondral bone growth;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;heterocycle biosynthetic process;regulation of biosynthetic process;tissue development;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;sensory organ development;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of RNA metabolic process;macromolecule metabolic process;system development;regulation of cellular biosynthetic process;regulation of cellular metabolic process;palate development;nucleic acid metabolic process;multicellular organism development;growth;regulation of cellular macromolecule biosynthetic process;regulation of biological process;tongue development;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;mesenchyme development;primary metabolic process;anatomical structure development;cellular metabolic process; 4;3;4;5;4;3;5;4;6;4;6;4;3;5;3;7;4;4;2;5;4;4;3;1;2;5;5;5;4;6;5;6;6;4;4;5;2;4;2;2;2;4;7;5;4;4;5;4;4;5;4;2;6;2;5;3;5;5;5;3;3;5;4;5;3;3;3; GO:0016020;GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0071944;GO:0005886;GO:0005575; membrane;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasm;nucleus;cell part;cell;cell periphery;plasma membrane;cellular_component; 2;4;3;3;3;3;2;4;5;2;2;3;3;1; GO:1901363;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043169;GO:0097159;GO:0043167; heterocyclic compound binding;metal ion binding;molecular_function;binding;nucleic acid binding;DNA binding;cation binding;organic cyclic compound binding;ion binding; 3;5;1;2;4;5;4;3;3; IPR013087; Zinc finger C2H2-type; nucleus Hs8923051 806.0 K [K] Transcription; P08571 Monocyte differentiation antigen CD14 OS=Homo sapiens OX=9606 GN=CD14 PE=1 SV=2 - [CD14_HUMAN] 0.982 0.933 1.121 0.92 0.927 1.404 1.052518757 0.605975502 0.992448759 0.618846444 1.201500536 0.043875948 1.514563107 0.038368062 GO:0032880;GO:2001235;GO:0032026;GO:0006909;GO:0080090;GO:0051046;GO:0051047;GO:0051049;GO:0070339;GO:0048584;GO:0048583;GO:0031349;GO:0008104;GO:0007165;GO:0007166;GO:0009966;GO:0044707;GO:0031347;GO:0043065;GO:0051716;GO:0043207;GO:0071726;GO:0071725;GO:0043067;GO:0042981;GO:0010467;GO:0044093;GO:0032729;GO:0035666;GO:0065007;GO:0033036;GO:0071727;GO:0060255;GO:0045184;GO:0052547;GO:0032268;GO:0030162;GO:0010038;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0009607;GO:0016192;GO:0009605;GO:0035556;GO:0031663;GO:0002376;GO:0019538;GO:0032640;GO:0060341;GO:0043281;GO:0007249;GO:1903532;GO:0032649;GO:0070201;GO:0008152;GO:1903555;GO:0032496;GO:0051223;GO:0050789;GO:0032493;GO:0006919;GO:0071724;GO:0010646;GO:0050708;GO:0002764;GO:0044260;GO:0051050;GO:0050707;GO:0016043;GO:0002684;GO:0002682;GO:0071219;GO:0071216;GO:0065009;GO:0034612;GO:0051130;GO:0032760;GO:0050790;GO:0034097;GO:0009306;GO:0006810;GO:2001233;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0008150;GO:0051239;GO:0006955;GO:0051234;GO:0044238;GO:0010604;GO:0051602;GO:0002755;GO:0002756;GO:0002757;GO:0006897;GO:0050715;GO:0050714;GO:0050896;GO:0006898;GO:0002758;GO:0032481;GO:0002218;GO:0009967;GO:0097305;GO:0006954;GO:0009617;GO:0043085;GO:0034142;GO:0009266;GO:0051128;GO:0023056;GO:0038123;GO:0023052;GO:1903530;GO:0070887;GO:0042221;GO:0010647;GO:1904951;GO:0044699;GO:0034138;GO:0010952;GO:0051240;GO:0051246;GO:0051247;GO:0032270;GO:0002224;GO:0006508;GO:0051641;GO:0002221;GO:0071840;GO:0051336;GO:0010950;GO:0032501;GO:0009628;GO:0031323;GO:0009987;GO:0071396;GO:0060627;GO:0048518;GO:0043280;GO:0016485;GO:0009408;GO:0032879;GO:0009893;GO:0023051;GO:0050776;GO:0051604;GO:0050778;GO:0001816;GO:0001817;GO:0002237;GO:0032479;GO:1903557;GO:0080134;GO:0001819;GO:0032609;GO:0071222;GO:0071223;GO:0071220;GO:0071221;GO:0034134;GO:0031325;GO:0097190;GO:0097191;GO:2001056;GO:0032606;GO:0043170;GO:0010942;GO:0008219;GO:0010941;GO:0051222;GO:0050663;GO:0070391;GO:0097202;GO:2000116;GO:0033993;GO:0032940;GO:0031638;GO:2001267;GO:0071704;GO:0071310;GO:0071706;GO:0071702;GO:0043068;GO:2001269;GO:0045089;GO:0045088;GO:0044267;GO:0052548;GO:0045087;GO:0006915;GO:0045471;GO:0044765;GO:0045862;GO:0044763;GO:0007154;GO:0019222;GO:0030100;GO:0051179;GO:1902578;GO:1901700;GO:1901701;GO:0051345;GO:0046903;GO:0044237;GO:0032680;GO:0038124;GO:0002253;GO:0015031;GO:0097296;GO:0045807;GO:0048522; regulation of protein localization;positive regulation of apoptotic signaling pathway;response to magnesium ion;phagocytosis;regulation of primary metabolic process;regulation of secretion;positive regulation of secretion;regulation of transport;response to bacterial lipopeptide;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;protein localization;signal transduction;cell surface receptor signaling pathway;regulation of signal transduction;single-multicellular organism process;regulation of defense response;positive regulation of apoptotic process;cellular response to stimulus;response to external biotic stimulus;cellular response to diacyl bacterial lipopeptide;response to triacyl bacterial lipopeptide;regulation of programmed cell death;regulation of apoptotic process;gene expression;positive regulation of molecular function;positive regulation of interferon-gamma production;TRIF-dependent toll-like receptor signaling pathway;biological regulation;macromolecule localization;cellular response to triacyl bacterial lipopeptide;regulation of macromolecule metabolic process;establishment of protein localization;regulation of peptidase activity;regulation of cellular protein metabolic process;regulation of proteolysis;response to metal ion;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;single organism signaling;response to biotic stimulus;vesicle-mediated transport;response to external stimulus;intracellular signal transduction;lipopolysaccharide-mediated signaling pathway;immune system process;protein metabolic process;tumor necrosis factor production;regulation of cellular localization;regulation of cysteine-type endopeptidase activity involved in apoptotic process;I-kappaB kinase/NF-kappaB signaling;positive regulation of secretion by cell;regulation of interferon-gamma production;regulation of establishment of protein localization;metabolic process;regulation of tumor necrosis factor superfamily cytokine production;response to lipopolysaccharide;regulation of protein transport;regulation of biological process;response to bacterial lipoprotein;activation of cysteine-type endopeptidase activity involved in apoptotic process;response to diacyl bacterial lipopeptide;regulation of cell communication;regulation of protein secretion;immune response-regulating signaling pathway;cellular macromolecule metabolic process;positive regulation of transport;regulation of cytokine secretion;cellular component organization;positive regulation of immune system process;regulation of immune system process;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;regulation of molecular function;response to tumor necrosis factor;positive regulation of cellular component organization;positive regulation of tumor necrosis factor production;regulation of catalytic activity;response to cytokine;protein secretion;transport;regulation of apoptotic signaling pathway;regulation of cellular process;defense response;programmed cell death;response to stress;biological_process;regulation of multicellular organismal process;immune response;establishment of localization;primary metabolic process;positive regulation of macromolecule metabolic process;response to electrical stimulus;MyD88-dependent toll-like receptor signaling pathway;MyD88-independent toll-like receptor signaling pathway;immune response-activating signal transduction;endocytosis;positive regulation of cytokine secretion;positive regulation of protein secretion;response to stimulus;receptor-mediated endocytosis;innate immune response-activating signal transduction;positive regulation of type I interferon production;activation of innate immune response;positive regulation of signal transduction;response to alcohol;inflammatory response;response to bacterium;positive regulation of catalytic activity;toll-like receptor 4 signaling pathway;response to temperature stimulus;regulation of cellular component organization;positive regulation of signaling;toll-like receptor TLR1:TLR2 signaling pathway;signaling;regulation of secretion by cell;cellular response to chemical stimulus;response to chemical;positive regulation of cell communication;positive regulation of establishment of protein localization;single-organism process;toll-like receptor 3 signaling pathway;positive regulation of peptidase activity;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;toll-like receptor signaling pathway;proteolysis;cellular localization;pattern recognition receptor signaling pathway;cellular component organization or biogenesis;regulation of hydrolase activity;positive regulation of endopeptidase activity;multicellular organismal process;response to abiotic stimulus;regulation of cellular metabolic process;cellular process;cellular response to lipid;regulation of vesicle-mediated transport;positive regulation of biological process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;protein processing;response to heat;regulation of localization;positive regulation of metabolic process;regulation of signaling;regulation of immune response;protein maturation;positive regulation of immune response;cytokine production;regulation of cytokine production;response to molecule of bacterial origin;regulation of type I interferon production;positive regulation of tumor necrosis factor superfamily cytokine production;regulation of response to stress;positive regulation of cytokine production;interferon-gamma production;cellular response to lipopolysaccharide;cellular response to lipoteichoic acid;cellular response to bacterial lipoprotein;cellular response to bacterial lipopeptide;toll-like receptor 2 signaling pathway;positive regulation of cellular metabolic process;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;positive regulation of cysteine-type endopeptidase activity;type I interferon production;macromolecule metabolic process;positive regulation of cell death;cell death;regulation of cell death;positive regulation of protein transport;cytokine secretion;response to lipoteichoic acid;activation of cysteine-type endopeptidase activity;regulation of cysteine-type endopeptidase activity;response to lipid;secretion by cell;zymogen activation;regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;organic substance metabolic process;cellular response to organic substance;tumor necrosis factor superfamily cytokine production;organic substance transport;positive regulation of programmed cell death;positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;positive regulation of innate immune response;regulation of innate immune response;cellular protein metabolic process;regulation of endopeptidase activity;innate immune response;apoptotic process;response to ethanol;single-organism transport;positive regulation of proteolysis;single-organism cellular process;cell communication;regulation of metabolic process;regulation of endocytosis;localization;single-organism localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;positive regulation of hydrolase activity;secretion;cellular metabolic process;regulation of tumor necrosis factor production;toll-like receptor TLR6:TLR2 signaling pathway;activation of immune response;protein transport;activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;positive regulation of endocytosis;positive regulation of cellular process; 4;5;6;5;4;5;4;4;7;3;3;4;4;4;5;4;3;5;6;3;4;8;8;5;6;5;4;5;9;2;3;8;4;4;6;5;6;5;4;3;4;2;3;3;5;3;5;6;2;4;6;4;7;6;4;5;5;2;5;5;5;2;6;7;8;4;6;5;4;3;5;3;3;3;5;4;3;6;4;6;4;5;5;4;5;3;4;5;3;1;3;3;3;3;4;4;8;8;4;6;5;5;2;7;5;5;4;4;5;5;4;5;8;4;4;3;8;2;5;4;3;4;3;2;8;7;3;5;5;5;7;5;3;6;2;5;8;2;3;4;2;6;4;2;7;6;4;3;3;3;4;5;4;4;4;5;5;5;4;4;5;6;6;6;7;8;4;5;6;9;5;4;4;4;4;4;5;5;8;8;5;4;7;6;3;5;5;5;5;6;5;5;5;7;4;6;6;4;6;3;4;3;5;2;3;4;5;6;5;3;6;8;3;5;6;4;3; GO:0031982;GO:0005773;GO:0016020;GO:0005774;GO:0005794;GO:0098588;GO:0098589;GO:0043230;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0044422;GO:0009897;GO:0046658;GO:0043229;GO:0043227;GO:0010008;GO:0044437;GO:0031224;GO:0031225;GO:0012505;GO:0044446;GO:0044444;GO:0044440;GO:0016021;GO:0031226;GO:0005737;GO:0031090;GO:0044459;GO:0009986;GO:0031233;GO:0031362;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098552;GO:0005615;GO:0098796;GO:0098805;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0045121;GO:0005575;GO:0005576;GO:0043235;GO:0046696;GO:0005768; vesicle;vacuole;membrane;vacuolar membrane;Golgi apparatus;bounding membrane of organelle;membrane region;extracellular organelle;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;membrane microdomain;extracellular region part;organelle part;external side of plasma membrane;anchored component of plasma membrane;intracellular organelle;membrane-bounded organelle;endosome membrane;vacuolar part;intrinsic component of membrane;anchored component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;endosomal part;integral component of membrane;intrinsic component of plasma membrane;cytoplasm;organelle membrane;plasma membrane part;cell surface;intrinsic component of external side of plasma membrane;anchored component of external side of plasma membrane;cell part;cell;intracellular;cell periphery;side of membrane;extracellular space;membrane protein complex;whole membrane;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;membrane raft;cellular_component;extracellular region;receptor complex;lipopolysaccharide receptor complex;endosome; 4;5;2;4;4;4;3;3;3;4;3;2;4;2;2;4;4;3;3;5;4;3;4;3;3;4;5;4;4;4;3;3;3;5;5;2;2;3;3;3;3;3;3;2;3;3;4;2;5;1;2;4;4;4; GO:0060089;GO:0097367;GO:0003674;GO:0005488;GO:0001847;GO:0070891;GO:0099600;GO:0038023;GO:0001530;GO:0008329;GO:0008289;GO:0016019;GO:0004872;GO:0004871;GO:0038187;GO:0004888; molecular transducer activity;carbohydrate derivative binding;molecular_function;binding;opsonin receptor activity;lipoteichoic acid binding;transmembrane receptor activity;signaling receptor activity;lipopolysaccharide binding;signaling pattern recognition receptor activity;lipid binding;peptidoglycan receptor activity;receptor activity;signal transducer activity;pattern recognition receptor activity;transmembrane signaling receptor activity; 2;3;1;2;5;4;4;3;4;4;3;5;3;2;4;4; K04391 map04010;map04064;map04145;map04620;map04640;map04810;map05130;map05132;map05133;map05134;map05146;map05152;map05202; MAPK signaling pathway;NF-kappa B signaling pathway;Phagosome;Toll-like receptor signaling pathway;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Salmonella infection;Pertussis;Legionellosis;Amoebiasis;Tuberculosis;Transcriptional misregulation in cancer; IPR016337;IPR032675;IPR001611; Monocyte differentiation antigen CD14;Leucine-rich repeat domain, L domain-like;Leucine-rich repeat; extracellular Q96Q05 Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2 - [TPPC9_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0019222;GO:0006901;GO:0006900;GO:0006903;GO:0061024;GO:0060322;GO:1901576;GO:0051656;GO:1901362;GO:0051650;GO:0071840;GO:0080090;GO:0044710;GO:0010604;GO:0048869;GO:0018196;GO:0018193;GO:0048513;GO:0044093;GO:0048518;GO:0046483;GO:0060255;GO:2001141;GO:0051668;GO:0016192;GO:0044707;GO:0019538;GO:0016050;GO:0018279;GO:0019438;GO:0021537;GO:0022607;GO:0009893;GO:0009891;GO:0009101;GO:0006807;GO:0097659;GO:0044267;GO:0006888;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0065009;GO:0018130;GO:0006810;GO:0009889;GO:0050794;GO:0021543;GO:0043412;GO:0043413;GO:0044802;GO:0008152;GO:0034654;GO:0051234;GO:0016070;GO:0090114;GO:0044271;GO:0007420;GO:0046907;GO:0009058;GO:0006355;GO:0010556;GO:0006351;GO:0008150;GO:0032774;GO:0070271;GO:0030154;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0007417;GO:0006139;GO:0051649;GO:0051640;GO:0036211;GO:0032502;GO:0032501;GO:1902591;GO:0043687;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0021987;GO:0051092;GO:0051091;GO:0051090;GO:1901137;GO:1901135;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0048731;GO:0048208;GO:1903508;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0048207;GO:0090304;GO:0009100;GO:0007275;GO:0044723;GO:0071822;GO:0006487;GO:2000112;GO:0010557;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045935;GO:0030182;GO:0048193;GO:0019219;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0044767;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0051648;GO:0051173;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0048699;GO:0005975;GO:0006486;GO:0007399;GO:0048856;GO:0044237;GO:1902589;GO:0044085;GO:0030900;GO:1902582;GO:1902580;GO:0048522; regulation of metabolic process;vesicle coating;membrane budding;vesicle targeting;membrane organization;head development;organic substance biosynthetic process;establishment of organelle localization;organic cyclic compound biosynthetic process;establishment of vesicle localization;cellular component organization or biogenesis;regulation of primary metabolic process;single-organism metabolic process;positive regulation of macromolecule metabolic process;cellular developmental process;peptidyl-asparagine modification;peptidyl-amino acid modification;animal organ development;positive regulation of molecular function;positive regulation of biological process;heterocycle metabolic process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;localization within membrane;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;vesicle organization;protein N-linked glycosylation via asparagine;aromatic compound biosynthetic process;telencephalon development;cellular component assembly;positive regulation of metabolic process;positive regulation of biosynthetic process;glycoprotein biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;regulation of molecular function;heterocycle biosynthetic process;transport;regulation of biosynthetic process;regulation of cellular process;pallium development;macromolecule modification;macromolecule glycosylation;single-organism membrane organization;metabolic process;nucleobase-containing compound biosynthetic process;establishment of localization;RNA metabolic process;COPII-coated vesicle budding;cellular nitrogen compound biosynthetic process;brain development;intracellular transport;biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;biological_process;RNA biosynthetic process;protein complex biogenesis;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;central nervous system development;nucleobase-containing compound metabolic process;establishment of localization in cell;organelle localization;protein modification process;developmental process;multicellular organismal process;single-organism membrane budding;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;cerebral cortex development;positive regulation of NF-kappaB transcription factor activity;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of sequence-specific DNA binding transcription factor activity;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;system development;COPII vesicle coating;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;vesicle targeting, rough ER to cis-Golgi;nucleic acid metabolic process;glycoprotein metabolic process;multicellular organism development;single-organism carbohydrate metabolic process;protein complex subunit organization;protein N-linked glycosylation;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;Golgi vesicle transport;regulation of nucleobase-containing compound metabolic process;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;single-organism developmental process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;vesicle localization;positive regulation of nitrogen compound metabolic process;neurogenesis;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;generation of neurons;carbohydrate metabolic process;protein glycosylation;nervous system development;anatomical structure development;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;forebrain development;single-organism intracellular transport;single-organism cellular localization;positive regulation of cellular process; 3;6;5;4;4;4;4;4;5;5;2;4;3;4;4;8;7;4;4;2;4;4;6;4;5;3;4;5;6;5;4;4;3;4;6;3;7;5;7;4;3;5;2;4;3;5;4;4;3;4;5;6;4;2;5;3;5;5;5;4;5;3;6;5;6;1;6;4;5;4;4;5;2;5;4;4;4;5;2;2;5;7;2;4;7;6;4;6;5;4;5;4;5;5;4;6;5;4;6;7;5;4;5;4;4;6;5;5;4;4;5;5;6;5;2;3;5;5;5;6;6;5;5;5;5;6;3;4;5;3;4;5;4;6;2;3;3;4;3;7;4;4;5;3;3;4;3;4;5;4;3; GO:0005783;GO:0031984;GO:0005794;GO:0098588;GO:0043231;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0016020;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005802;GO:0005575;GO:0098791; endoplasmic reticulum;organelle subcompartment;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;membrane;cytoplasm;organelle membrane;cell part;cell;trans-Golgi network;cellular_component;Golgi subcompartment; 4;4;4;4;4;5;3;2;3;3;3;2;4;3;5;3;4;2;4;3;2;2;5;1;5; K20306 IPR013783;IPR011990;IPR013935; Immunoglobulin-like fold;Tetratricopeptide-like helical domain;TRAPP II complex, Trs120; cytosol A3KN83 Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1 - [SBNO1_HUMAN] 0.906 1.035 1.122 0.963 1.132 1.036 0.875362319 nan 0.850706714 nan 1.084057971 nan 0.915194346 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; IPR026741;IPR027417;IPR026937; Protein strawberry notch;P-loop containing nucleoside triphosphate hydrolase;Strawberry notch, helicase C domain; nucleus 7292847 1384.0 KT [K] Transcription;[T] Signal transduction mechanisms; A0A0B4J2H0 Immunoglobulin heavy variable 1-69D OS=Homo sapiens OX=9606 GN=IGHV1-69D PE=1 SV=1 - [HV69D_HUMAN] 1.219 0.978 0.575 1.023 1.05 2.372 1.246421268 0.369234832 0.974285714 0.87103452 0.58793456 0.119542822 2.259047619 0.026225188 IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q8WZ42 Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4 - [TITIN_HUMAN] 0.683 0.66 1.978 0.768 0.732 0.733 1.034848485 0.512152937 1.049180328 0.513937674 2.996969697 0.000755797 1.00136612 0.389232915 GO:0006887;GO:0007599;GO:0019222;GO:0007596;GO:0048468;GO:0003012;GO:0003013;GO:0003015;GO:0019220;GO:0071840;GO:0080090;GO:0007517;GO:0071704;GO:0048869;GO:0071688;GO:0009611;GO:0009612;GO:0055006;GO:0006936;GO:0006793;GO:0060255;GO:0048769;GO:0045859;GO:0051592;GO:0010038;GO:0007076;GO:0010035;GO:0050794;GO:0003008;GO:0043412;GO:0044707;GO:0019538;GO:0072359;GO:0007067;GO:0050789;GO:0072358;GO:0030048;GO:0042692;GO:0043549;GO:0071103;GO:0022607;GO:0006468;GO:0006928;GO:0031399;GO:0043170;GO:0035994;GO:0035995;GO:0051246;GO:0044260;GO:0016043;GO:0045055;GO:0065003;GO:0065007;GO:0044267;GO:0065009;GO:0065008;GO:0048644;GO:0048646;GO:0009887;GO:0008015;GO:0042325;GO:0006810;GO:0042060;GO:0009888;GO:0006950;GO:0050817;GO:0008150;GO:0048747;GO:0008152;GO:0007507;GO:0007059;GO:0051234;GO:0044238;GO:0051174;GO:0046903;GO:0051606;GO:1903047;GO:0050896;GO:0051338;GO:0014897;GO:0060415;GO:0070271;GO:0003007;GO:0016310;GO:0030154;GO:0010927;GO:0006941;GO:0060047;GO:0018193;GO:0061061;GO:0055013;GO:0009653;GO:0060048;GO:0044699;GO:0036211;GO:0003300;GO:0033275;GO:0048513;GO:0000280;GO:0032502;GO:0055001;GO:0055002;GO:0032501;GO:0050878;GO:0007015;GO:0055008;GO:0009987;GO:0045214;GO:0018108;GO:0007049;GO:0032268;GO:0000819;GO:0098813;GO:0032940;GO:0048738;GO:0048739;GO:0048731;GO:0030168;GO:0030049;GO:0031034;GO:0031033;GO:0031032;GO:0043933;GO:0030241;GO:0051146;GO:0031323;GO:0030036;GO:0014706;GO:0014866;GO:0022402;GO:0034622;GO:0007275;GO:0071822;GO:0050982;GO:0002576;GO:0055007;GO:0030240;GO:0014896;GO:0006323;GO:0032989;GO:0006796;GO:0001775;GO:0048729;GO:0009605;GO:0030261;GO:0009581;GO:0009582;GO:0000278;GO:0030029;GO:0030239;GO:0006461;GO:0035051;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0042221;GO:0070925;GO:0043623;GO:0051179;GO:1902578;GO:0006996;GO:0009628;GO:0000070;GO:0007010;GO:0051276;GO:0050790;GO:0055003;GO:0048856;GO:0044237;GO:0018212;GO:1902589;GO:0044085;GO:0048285;GO:0060537;GO:0070252;GO:0001932;GO:0016192; exocytosis;hemostasis;regulation of metabolic process;blood coagulation;cell development;muscle system process;circulatory system process;heart process;regulation of phosphate metabolic process;cellular component organization or biogenesis;regulation of primary metabolic process;muscle organ development;organic substance metabolic process;cellular developmental process;striated muscle myosin thick filament assembly;response to wounding;response to mechanical stimulus;cardiac cell development;muscle contraction;phosphorus metabolic process;regulation of macromolecule metabolic process;sarcomerogenesis;regulation of protein kinase activity;response to calcium ion;response to metal ion;mitotic chromosome condensation;response to inorganic substance;regulation of cellular process;system process;macromolecule modification;single-multicellular organism process;protein metabolic process;circulatory system development;mitotic nuclear division;regulation of biological process;cardiovascular system development;actin filament-based movement;muscle cell differentiation;regulation of kinase activity;DNA conformation change;cellular component assembly;protein phosphorylation;movement of cell or subcellular component;regulation of protein modification process;macromolecule metabolic process;response to muscle stretch;detection of muscle stretch;regulation of protein metabolic process;cellular macromolecule metabolic process;cellular component organization;regulated exocytosis;macromolecular complex assembly;biological regulation;cellular protein metabolic process;regulation of molecular function;regulation of biological quality;muscle organ morphogenesis;anatomical structure formation involved in morphogenesis;organ morphogenesis;blood circulation;regulation of phosphorylation;transport;wound healing;tissue development;response to stress;coagulation;biological_process;muscle fiber development;metabolic process;heart development;chromosome segregation;establishment of localization;primary metabolic process;regulation of phosphorus metabolic process;secretion;detection of stimulus;mitotic cell cycle process;response to stimulus;regulation of transferase activity;striated muscle hypertrophy;muscle tissue morphogenesis;protein complex biogenesis;heart morphogenesis;phosphorylation;cell differentiation;cellular component assembly involved in morphogenesis;striated muscle contraction;heart contraction;peptidyl-amino acid modification;muscle structure development;cardiac muscle cell development;anatomical structure morphogenesis;cardiac muscle contraction;single-organism process;protein modification process;cardiac muscle hypertrophy;actin-myosin filament sliding;animal organ development;nuclear division;developmental process;muscle cell development;striated muscle cell development;multicellular organismal process;regulation of body fluid levels;actin filament organization;cardiac muscle tissue morphogenesis;cellular process;sarcomere organization;peptidyl-tyrosine phosphorylation;cell cycle;regulation of cellular protein metabolic process;sister chromatid segregation;nuclear chromosome segregation;secretion by cell;cardiac muscle tissue development;cardiac muscle fiber development;system development;platelet activation;muscle filament sliding;myosin filament assembly;myosin filament organization;actomyosin structure organization;macromolecular complex subunit organization;skeletal muscle myosin thick filament assembly;striated muscle cell differentiation;regulation of cellular metabolic process;actin cytoskeleton organization;striated muscle tissue development;skeletal myofibril assembly;cell cycle process;cellular macromolecular complex assembly;multicellular organism development;protein complex subunit organization;detection of mechanical stimulus;platelet degranulation;cardiac muscle cell differentiation;skeletal muscle thin filament assembly;muscle hypertrophy;DNA packaging;cellular component morphogenesis;phosphate-containing compound metabolic process;cell activation;tissue morphogenesis;response to external stimulus;chromosome condensation;detection of external stimulus;detection of abiotic stimulus;mitotic cell cycle;actin filament-based process;myofibril assembly;protein complex assembly;cardiocyte differentiation;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to chemical;organelle assembly;cellular protein complex assembly;localization;single-organism localization;organelle organization;response to abiotic stimulus;mitotic sister chromatid segregation;cytoskeleton organization;chromosome organization;regulation of catalytic activity;cardiac myofibril assembly;anatomical structure development;cellular metabolic process;peptidyl-tyrosine modification;single-organism organelle organization;cellular component biogenesis;organelle fission;muscle tissue development;actin-mediated cell contraction;regulation of protein phosphorylation;vesicle-mediated transport; 5;5;3;5;4;4;4;5;6;2;4;5;3;4;5;4;4;5;5;4;4;6;7;6;5;6;4;3;3;5;3;4;5;5;2;5;5;5;6;6;4;7;4;6;4;5;6;5;4;3;6;5;2;5;3;3;5;3;4;5;7;4;5;4;3;4;1;7;2;4;4;3;3;5;5;3;5;2;5;6;5;4;5;6;5;4;6;6;7;4;6;3;7;2;5;7;7;4;6;2;5;6;2;4;6;6;2;6;8;4;5;5;5;4;5;6;4;5;6;7;6;6;4;6;6;4;5;6;6;4;6;4;5;5;7;6;7;5;7;4;5;4;4;3;5;4;4;5;4;5;5;5;6;3;4;3;3;5;6;2;3;4;3;6;5;5;4;6;3;3;8;4;3;5;5;6;7;5; GO:0000794;GO:0031974;GO:0031982;GO:0031981;GO:0016459;GO:0016460;GO:0036379;GO:0005856;GO:0043234;GO:0030016;GO:0043230;GO:0043232;GO:0043233;GO:0005829;GO:0043231;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0000228;GO:0043227;GO:0043226;GO:0031672;GO:0031674;GO:0044430;GO:0030018;GO:0005859;GO:0044446;GO:0044444;GO:0044449;GO:0030017;GO:0015629;GO:0005737;GO:1903561;GO:0005634;GO:0032991;GO:0005865;GO:0044464;GO:0005623;GO:0005622;GO:0031430;GO:0070062;GO:0005576;GO:0005694;GO:0000793;GO:0005575;GO:0070013;GO:0043292; condensed nuclear chromosome;membrane-enclosed lumen;vesicle;nuclear lumen;myosin complex;myosin II complex;myofilament;cytoskeleton;protein complex;myofibril;extracellular organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;intracellular membrane-bounded organelle;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome;membrane-bounded organelle;organelle;A band;I band;cytoskeletal part;Z disc;muscle myosin complex;intracellular organelle part;cytoplasmic part;contractile fiber part;sarcomere;actin cytoskeleton;cytoplasm;extracellular vesicle;nucleus;macromolecular complex;striated muscle thin filament;cell part;cell;intracellular;M band;extracellular exosome;extracellular region;chromosome;condensed chromosome;cellular_component;intracellular organelle lumen;contractile fiber; 6;2;4;5;4;5;4;5;3;6;3;4;3;5;4;4;3;2;2;3;3;5;3;2;4;4;4;4;4;3;4;3;4;6;4;3;5;2;5;2;2;3;4;4;2;5;6;1;4;5; GO:0019901;GO:0005198;GO:1901363;GO:0003779;GO:0000166;GO:0035639;GO:0016740;GO:0004713;GO:0046872;GO:0044877;GO:0017076;GO:0097367;GO:0005524;GO:0003674;GO:0005488;GO:0097493;GO:0032549;GO:0043168;GO:0016301;GO:0003824;GO:0008092;GO:0016773;GO:0016772;GO:0008307;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0019899;GO:0043169;GO:0043621;GO:0036094;GO:0043167;GO:0005509;GO:0002020;GO:0032403;GO:0042805;GO:0042802;GO:0051015;GO:0051371;GO:0030554;GO:0051393;GO:0005516;GO:0005515;GO:0097159;GO:0001883;GO:0001882;GO:0031433;GO:0004674;GO:1901265;GO:0004672;GO:0019900; protein kinase binding;structural molecule activity;heterocyclic compound binding;actin binding;nucleotide binding;purine ribonucleoside triphosphate binding;transferase activity;protein tyrosine kinase activity;metal ion binding;macromolecular complex binding;purine nucleotide binding;carbohydrate derivative binding;ATP binding;molecular_function;binding;structural molecule activity conferring elasticity;ribonucleoside binding;anion binding;kinase activity;catalytic activity;cytoskeletal protein binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;structural constituent of muscle;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;enzyme binding;cation binding;protein self-association;small molecule binding;ion binding;calcium ion binding;protease binding;protein complex binding;actinin binding;identical protein binding;actin filament binding;muscle alpha-actinin binding;adenyl nucleotide binding;alpha-actinin binding;calmodulin binding;protein binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;telethonin binding;protein serine/threonine kinase activity;nucleoside phosphate binding;protein kinase activity;kinase binding; 6;2;3;5;4;5;3;7;5;3;5;3;6;1;2;3;5;4;5;2;4;5;4;3;6;5;6;4;4;4;4;3;3;6;5;4;5;4;5;7;6;6;4;3;3;5;4;5;7;4;6;5; K12567 map05410;map05414; Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy; IPR003599;IPR007110;IPR013783;IPR011009;IPR003598;IPR008266;IPR003961;IPR000719;IPR015129;IPR013106;IPR013098;IPR004168; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Protein kinase-like domain;Immunoglobulin subtype 2;Tyrosine-protein kinase, active site;Fibronectin type III;Protein kinase domain;Titin, Z repeat;Immunoglobulin V-set domain;Immunoglobulin I-set;PPAK motif; Hs19747267 70135.0 Z [Z] Cytoskeleton; Q15477 Helicase SKI2W OS=Homo sapiens OX=9606 GN=SKIV2L PE=1 SV=3 - [SKIV2_HUMAN] 1.019 1.171 0.772 1.683 1.017 nan 0.870196413 nan 1.654867257 nan 0.659265585 nan nan nan GO:1901360;GO:1901361;GO:0046483;GO:0019439;GO:0006807;GO:1901575;GO:0044265;GO:0044260;GO:0046700;GO:0008150;GO:0008152;GO:0034655;GO:0016070;GO:0044270;GO:0044248;GO:0034641;GO:0006139;GO:0009987;GO:0006725;GO:0043170;GO:0090304;GO:0071704;GO:0006401;GO:0009056;GO:0009057;GO:0044238;GO:0044237; organic cyclic compound metabolic process;organic cyclic compound catabolic process;heterocycle metabolic process;aromatic compound catabolic process;nitrogen compound metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;heterocycle catabolic process;biological_process;metabolic process;nucleobase-containing compound catabolic process;RNA metabolic process;cellular nitrogen compound catabolic process;cellular catabolic process;cellular nitrogen compound metabolic process;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;macromolecule metabolic process;nucleic acid metabolic process;organic substance metabolic process;RNA catabolic process;catabolic process;macromolecule catabolic process;primary metabolic process;cellular metabolic process; 4;5;4;5;3;4;5;4;5;1;2;5;5;5;4;4;4;2;4;4;5;3;6;3;5;3;3; GO:0031974;GO:0031981;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0005737;GO:0044446;GO:0044444;GO:0005634;GO:0055087;GO:0044464;GO:0005623;GO:0044424;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;cytoplasm;intracellular organelle part;cytoplasmic part;nucleus;Ski complex;cell part;cell;intracellular part;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;3;4;3;4;2;3;3;3;2;5;4;3;4;5;4;2;2;3;2;1;4; GO:0008186;GO:1901363;GO:0000166;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0016787;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008026;GO:0035639;GO:0043168;GO:0043167;GO:0030554;GO:0003724;GO:0003723;GO:0016887;GO:0001883;GO:0001882;GO:0017111;GO:0004004;GO:0036094; RNA-dependent ATPase activity;heterocyclic compound binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;hydrolase activity;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;anion binding;ion binding;adenyl nucleotide binding;RNA helicase activity;RNA binding;ATPase activity;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;ATP-dependent RNA helicase activity;small molecule binding; 10;3;4;8;5;3;4;9;3;1;2;4;4;9;5;5;6;2;3;6;6;5;6;4;10;5;4;3;6;9;5;8;5;4;7;10;3; K12599 map03018; RNA degradation; IPR011545;IPR001650;IPR016438;IPR014001;IPR025696;IPR012961;IPR027417; DEAD/DEAH box helicase domain;Helicase, C-terminal;ATP-dependent RNA helicase Ski2;Helicase superfamily 1/2, ATP-binding domain;rRNA-processing arch domain;ATP-dependent RNA helicase Ski2, C-terminal;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs20631987 2546.0 A [A] RNA processing and modification; P35527 Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 - [K1C9_HUMAN] 0.882 0.693 1.418 0.906 0.925 1.776 1.272727273 0.000186244 0.979459459 0.302573152 2.046176046 1.65E-08 1.92 5.60E-06 GO:0044707;GO:0043933;GO:0060429;GO:0019953;GO:0007276;GO:0045103;GO:0071840;GO:0008544;GO:0071822;GO:0016043;GO:0044699;GO:0051704;GO:0043588;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0000003;GO:0009987;GO:0009888;GO:0048731;GO:0044767;GO:0022414;GO:0007283;GO:0008150;GO:0048232;GO:0007010;GO:0006996;GO:0048513;GO:0044703;GO:0044702;GO:0045104;GO:0048856;GO:1902589;GO:0045109;GO:0044763;GO:0007275; single-multicellular organism process;macromolecular complex subunit organization;epithelium development;sexual reproduction;gamete generation;intermediate filament-based process;cellular component organization or biogenesis;epidermis development;protein complex subunit organization;cellular component organization;single-organism process;multi-organism process;skin development;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;reproduction;cellular process;tissue development;system development;single-organism developmental process;reproductive process;spermatogenesis;biological_process;male gamete generation;cytoskeleton organization;organelle organization;animal organ development;multi-organism reproductive process;single organism reproductive process;intermediate filament cytoskeleton organization;anatomical structure development;single-organism organelle organization;intermediate filament organization;single-organism cellular process;multicellular organism development; 3;4;5;3;4;4;2;6;5;3;2;2;5;2;2;3;3;2;2;4;4;3;2;6;1;5;5;4;4;3;3;5;3;4;6;3;4; GO:0099512;GO:0099513;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044446;GO:0045111;GO:0070062;GO:0005615;GO:0005634;GO:0016020;GO:0044430;GO:0005882;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;intracellular organelle part;intermediate filament cytoskeleton;extracellular exosome;extracellular space;nucleus;membrane;cytoskeletal part;intermediate filament;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;3;3;3;2;5;3;6;4;3;5;2;4;4;3;4;3;4;4;2;2;3;1;2;3;2;2; GO:0005200;GO:0003674;GO:0005198; structural constituent of cytoskeleton;molecular_function;structural molecule activity; 3;1;2; K07604 IPR001664;IPR018039;IPR002957; Intermediate filament protein;Intermediate filament protein, conserved site;Keratin, type I; nucleus P36888 Receptor-type tyrosine-protein kinase FLT3 OS=Homo sapiens OX=9606 GN=FLT3 PE=1 SV=2 - [FLT3_HUMAN] 1.375 0.91 0.907 1.258 0.755 1.078 1.510989011 nan 1.666225166 nan 0.996703297 nan 1.42781457 nan GO:0019216;GO:0019220;GO:0019221;GO:0019222;GO:0048584;GO:0048583;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0023014;GO:0035726;GO:0051716;GO:0010604;GO:0002328;GO:0009966;GO:0009967;GO:0000165;GO:0043067;GO:0018193;GO:0042981;GO:0048513;GO:0045834;GO:0044093;GO:0048518;GO:0042127;GO:0031100;GO:0060255;GO:0031960;GO:0045859;GO:0046649;GO:0010033;GO:0048872;GO:0042325;GO:0044700;GO:0042327;GO:0044707;GO:0019538;GO:0050730;GO:0010243;GO:1904892;GO:0002376;GO:0050731;GO:0007154;GO:0071407;GO:0035924;GO:0009893;GO:0033674;GO:0002244;GO:0008284;GO:0032943;GO:0001776;GO:0046651;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0006629;GO:0044267;GO:0051347;GO:0044260;GO:0043549;GO:0065007;GO:0014070;GO:0065009;GO:0065008;GO:0043085;GO:0034097;GO:0090218;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0048731;GO:1902533;GO:1902531;GO:0048015;GO:0002521;GO:0002520;GO:0043551;GO:0044767;GO:0043552;GO:0071345;GO:0050896;GO:0031401;GO:0001775;GO:0051338;GO:0048869;GO:0030098;GO:0016310;GO:0030154;GO:0070848;GO:0023056;GO:0043406;GO:0043405;GO:0023052;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0046777;GO:0044699;GO:0043408;GO:0009719;GO:0038084;GO:1903727;GO:0010562;GO:0051246;GO:0051247;GO:0007259;GO:0032270;GO:0048017;GO:0031399;GO:0097028;GO:0031325;GO:0071495;GO:0006644;GO:0043170;GO:0046425;GO:0008283;GO:0031323;GO:0009987;GO:0071396;GO:0042113;GO:0032870;GO:0014068;GO:0014065;GO:0044255;GO:0014066;GO:0032268;GO:0071363;GO:0045321;GO:0009725;GO:0030097;GO:0045860;GO:1901698;GO:0048545;GO:1904894;GO:0032502;GO:0051384;GO:0071383;GO:0071385;GO:0071384;GO:0018108;GO:0042592;GO:0032501;GO:0008219;GO:0010941;GO:0007275;GO:0019637;GO:0033993;GO:0070661;GO:0071704;GO:0071310;GO:0030183;GO:0097696;GO:0002320;GO:0048534;GO:0043550;GO:0006468;GO:0042531;GO:0046427;GO:0045937;GO:0031099;GO:0006915;GO:0080090;GO:0006464;GO:0051174;GO:0044763;GO:0042221;GO:0007260;GO:0042509;GO:0044238;GO:1903725;GO:0048856;GO:0044237;GO:0018212;GO:0006796;GO:0002318;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of lipid metabolic process;regulation of phosphate metabolic process;cytokine-mediated signaling pathway;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;signal transduction by protein phosphorylation;common myeloid progenitor cell proliferation;cellular response to stimulus;positive regulation of macromolecule metabolic process;pro-B cell differentiation;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;regulation of programmed cell death;peptidyl-amino acid modification;regulation of apoptotic process;animal organ development;positive regulation of lipid metabolic process;positive regulation of molecular function;positive regulation of biological process;regulation of cell proliferation;organ regeneration;regulation of macromolecule metabolic process;response to corticosteroid;regulation of protein kinase activity;lymphocyte activation;response to organic substance;homeostasis of number of cells;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;single-multicellular organism process;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;response to organonitrogen compound;regulation of STAT cascade;immune system process;positive regulation of peptidyl-tyrosine phosphorylation;cell communication;cellular response to organic cyclic compound;cellular response to vascular endothelial growth factor stimulus;positive regulation of metabolic process;positive regulation of kinase activity;hematopoietic progenitor cell differentiation;positive regulation of cell proliferation;mononuclear cell proliferation;leukocyte homeostasis;lymphocyte proliferation;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;lipid metabolic process;cellular protein metabolic process;positive regulation of transferase activity;cellular macromolecule metabolic process;regulation of kinase activity;biological regulation;response to organic cyclic compound;regulation of molecular function;regulation of biological quality;positive regulation of catalytic activity;response to cytokine;positive regulation of lipid kinase activity;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;system development;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;phosphatidylinositol-mediated signaling;leukocyte differentiation;immune system development;regulation of phosphatidylinositol 3-kinase activity;single-organism developmental process;positive regulation of phosphatidylinositol 3-kinase activity;cellular response to cytokine stimulus;response to stimulus;positive regulation of protein modification process;cell activation;regulation of transferase activity;cellular developmental process;lymphocyte differentiation;phosphorylation;cell differentiation;response to growth factor;positive regulation of signaling;positive regulation of MAP kinase activity;regulation of MAP kinase activity;signaling;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;protein autophosphorylation;single-organism process;regulation of MAPK cascade;response to endogenous stimulus;vascular endothelial growth factor signaling pathway;positive regulation of phospholipid metabolic process;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;JAK-STAT cascade;positive regulation of cellular protein metabolic process;inositol lipid-mediated signaling;regulation of protein modification process;dendritic cell differentiation;positive regulation of cellular metabolic process;cellular response to endogenous stimulus;phospholipid metabolic process;macromolecule metabolic process;regulation of JAK-STAT cascade;cell proliferation;regulation of cellular metabolic process;cellular process;cellular response to lipid;B cell activation;cellular response to hormone stimulus;positive regulation of phosphatidylinositol 3-kinase signaling;phosphatidylinositol 3-kinase signaling;cellular lipid metabolic process;regulation of phosphatidylinositol 3-kinase signaling;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;leukocyte activation;response to hormone;hemopoiesis;positive regulation of protein kinase activity;response to nitrogen compound;response to steroid hormone;positive regulation of STAT cascade;developmental process;response to glucocorticoid;cellular response to steroid hormone stimulus;cellular response to glucocorticoid stimulus;cellular response to corticosteroid stimulus;peptidyl-tyrosine phosphorylation;homeostatic process;multicellular organismal process;cell death;regulation of cell death;multicellular organism development;organophosphate metabolic process;response to lipid;leukocyte proliferation;organic substance metabolic process;cellular response to organic substance;B cell differentiation;STAT cascade;lymphoid progenitor cell differentiation;hematopoietic or lymphoid organ development;regulation of lipid kinase activity;protein phosphorylation;positive regulation of tyrosine phosphorylation of STAT protein;positive regulation of JAK-STAT cascade;positive regulation of phosphate metabolic process;regeneration;apoptotic process;regulation of primary metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;response to chemical;tyrosine phosphorylation of STAT protein;regulation of tyrosine phosphorylation of STAT protein;primary metabolic process;regulation of phospholipid metabolic process;anatomical structure development;cellular metabolic process;peptidyl-tyrosine modification;phosphate-containing compound metabolic process;myeloid progenitor cell differentiation;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 5;6;6;3;3;3;4;5;6;7;4;4;3;4;8;4;4;5;5;7;6;4;4;4;2;4;5;4;6;7;4;4;5;7;3;7;3;4;8;4;6;2;8;4;6;7;3;7;6;4;5;3;5;9;5;8;2;4;5;6;4;6;2;5;3;3;5;5;5;4;3;3;6;5;5;5;1;2;4;5;5;7;6;3;7;3;6;6;2;6;4;5;4;5;6;5;5;3;7;7;2;4;3;4;4;8;2;6;3;8;5;5;5;5;7;5;6;6;7;4;4;5;4;7;3;4;2;6;5;5;6;8;4;6;5;6;3;4;5;8;4;5;6;2;7;6;8;7;8;4;2;4;4;4;4;5;4;3;5;6;6;7;4;6;7;8;7;6;4;6;4;6;5;3;3;8;8;3;6;3;3;8;5;7;4;7;7;3; GO:0031974;GO:0031224;GO:0005783;GO:0016021;GO:0016020;GO:0043234;GO:0005788;GO:0043231;GO:0043233;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0005737;GO:0044459;GO:0071944;GO:0012505;GO:0044446;GO:0044444;GO:0005634;GO:0031226;GO:0044464;GO:0005623;GO:0005622;GO:0005829;GO:0043226;GO:0005887;GO:0005886;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;intrinsic component of membrane;endoplasmic reticulum;integral component of membrane;membrane;protein complex;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;cytoplasm;plasma membrane part;cell periphery;endomembrane system;intracellular organelle part;cytoplasmic part;nucleus;intrinsic component of plasma membrane;cell part;cell;intracellular;cytosol;organelle;integral component of plasma membrane;plasma membrane;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;4;4;2;3;5;4;3;3;2;2;3;3;4;4;3;3;3;3;4;5;4;2;2;3;5;2;4;3;2;1;4; GO:0060089;GO:1901363;GO:0000166;GO:0004713;GO:0097367;GO:0004896;GO:0030554;GO:0003674;GO:0005488;GO:1901265;GO:0004714;GO:0032549;GO:0017076;GO:0005524;GO:0016301;GO:0003824;GO:0016772;GO:0043168;GO:0016740;GO:0032559;GO:0099600;GO:0032555;GO:0046983;GO:0032553;GO:0035639;GO:0042802;GO:0042803;GO:0005021;GO:0016773;GO:0032550;GO:0005515;GO:0097159;GO:0038023;GO:0036094;GO:0004872;GO:0004871;GO:0001883;GO:0001882;GO:0004888;GO:0004672;GO:0019199;GO:0043167; molecular transducer activity;heterocyclic compound binding;nucleotide binding;protein tyrosine kinase activity;carbohydrate derivative binding;cytokine receptor activity;adenyl nucleotide binding;molecular_function;binding;nucleoside phosphate binding;transmembrane receptor protein tyrosine kinase activity;ribonucleoside binding;purine nucleotide binding;ATP binding;kinase activity;catalytic activity;transferase activity, transferring phosphorus-containing groups;anion binding;transferase activity;adenyl ribonucleotide binding;transmembrane receptor activity;purine ribonucleotide binding;protein dimerization activity;ribonucleotide binding;purine ribonucleoside triphosphate binding;identical protein binding;protein homodimerization activity;vascular endothelial growth factor-activated receptor activity;phosphotransferase activity, alcohol group as acceptor;purine ribonucleoside binding;protein binding;organic cyclic compound binding;signaling receptor activity;small molecule binding;receptor activity;signal transducer activity;purine nucleoside binding;nucleoside binding;transmembrane signaling receptor activity;protein kinase activity;transmembrane receptor protein kinase activity;ion binding; 2;3;4;7;3;5;6;1;2;4;6;5;5;6;5;2;4;4;3;6;4;5;4;4;5;4;5;7;5;6;3;3;3;3;3;2;5;4;4;6;5;3; K05092 map04060;map04640;map05200;map05202;map05221;map05230; Cytokine-cytokine receptor interaction;Hematopoietic cell lineage;Pathways in cancer;Transcriptional misregulation in cancer;Acute myeloid leukemia;Central carbon metabolism in cancer; IPR007110;IPR013783;IPR001824;IPR011009;IPR000719;IPR008266;IPR001245;IPR030118;IPR017441;IPR013151;IPR020635; Immunoglobulin-like domain;Immunoglobulin-like fold;Tyrosine-protein kinase, receptor class III, conserved site;Protein kinase-like domain;Protein kinase domain;Tyrosine-protein kinase, active site;Serine-threonine/tyrosine-protein kinase, catalytic domain;Receptor-type tyrosine-protein kinase FLT3;Protein kinase, ATP binding site;Immunoglobulin;Tyrosine-protein kinase, catalytic domain; extracellular Hs4758396 2069.0 T [T] Signal transduction mechanisms; Q14520 Hyaluronan-binding protein 2 OS=Homo sapiens OX=9606 GN=HABP2 PE=1 SV=1 - [HABP2_HUMAN] 1.038 0.943 1.11 1.022 0.931 0.993 1.100742312 0.002444183 1.097744361 0.006323417 1.17709438 0.001264629 1.066595059 0.122206648 GO:0008150;GO:0007155;GO:0022610; biological_process;cell adhesion;biological adhesion; 1;3;2; GO:0005575;GO:0005615;GO:0005576;GO:0044421; cellular_component;extracellular space;extracellular region;extracellular region part; 1;3;2;2; GO:0004252;GO:0004175;GO:0016787;GO:0097367;GO:0017171;GO:0005539;GO:0003824;GO:0070011;GO:0003674;GO:0005488;GO:0008233;GO:0008236; serine-type endopeptidase activity;endopeptidase activity;hydrolase activity;carbohydrate derivative binding;serine hydrolase activity;glycosaminoglycan binding;catalytic activity;peptidase activity, acting on L-amino acid peptides;molecular_function;binding;peptidase activity;serine-type peptidase activity; 6;6;3;3;4;4;2;5;1;2;4;5; K08648 IPR000742;IPR018056;IPR013806;IPR009003;IPR000001;IPR018114;IPR013032;IPR001881;IPR001254;IPR033116;IPR001314; EGF-like domain;Kringle, conserved site;Kringle-like fold;Peptidase S1, PA clan;Kringle;Serine proteases, trypsin family, histidine active site;EGF-like, conserved site;EGF-like calcium-binding domain;Serine proteases, trypsin domain;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular Hs4758502_1 659.0 T [T] Signal transduction mechanisms; P08185 Corticosteroid-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA6 PE=1 SV=1 - [CBG_HUMAN] 0.974 1.027 0.966 0.976 1.02 1.228 0.948393379 0.032749455 0.956862745 0.586581904 0.9406037 0.035787403 1.203921569 4.68E-05 GO:0009892;GO:0080090;GO:0019222;GO:0031324;GO:0031323;GO:0050789;GO:0008211;GO:0043086;GO:0044699;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0051246;GO:0071704;GO:0010466;GO:0065007;GO:1901360;GO:0044092;GO:0048519;GO:0065009;GO:0009987;GO:0006629;GO:0052547;GO:0052548;GO:0006810;GO:0044710;GO:0050794;GO:0008150;GO:0008152;GO:0006508;GO:0010951;GO:0051234;GO:0051346;GO:0051179;GO:0008202;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0050790;GO:0060255;GO:0044237;GO:0043170;GO:0019538;GO:0030162;GO:0045861;GO:0048523; negative regulation of metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of biological process;glucocorticoid metabolic process;negative regulation of catalytic activity;single-organism process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;organic cyclic compound metabolic process;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;cellular process;lipid metabolic process;regulation of peptidase activity;regulation of endopeptidase activity;transport;single-organism metabolic process;regulation of cellular process;biological_process;metabolic process;proteolysis;negative regulation of endopeptidase activity;establishment of localization;negative regulation of hydrolase activity;localization;steroid metabolic process;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of catalytic activity;regulation of macromolecule metabolic process;cellular metabolic process;macromolecule metabolic process;protein metabolic process;regulation of proteolysis;negative regulation of proteolysis;negative regulation of cellular process; 3;4;3;4;4;2;6;5;2;5;5;4;4;5;3;7;2;4;4;2;3;2;4;6;7;4;3;3;1;2;5;8;3;6;2;5;5;3;5;5;4;4;3;4;4;6;6;3; GO:0043227;GO:1903561;GO:0070062;GO:0005615;GO:0043226;GO:0031982;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;extracellular vesicle;extracellular exosome;extracellular space;organelle;vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;3;4;3;2;4;3;1;2;2; GO:0005496;GO:0003674;GO:0005488;GO:0008289;GO:0004857;GO:0098772;GO:0061134;GO:0061135;GO:0030414;GO:0004866;GO:0030234;GO:0097159;GO:0004867; steroid binding;molecular_function;binding;lipid binding;enzyme inhibitor activity;molecular function regulator;peptidase regulator activity;endopeptidase regulator activity;peptidase inhibitor activity;endopeptidase inhibitor activity;enzyme regulator activity;organic cyclic compound binding;serine-type endopeptidase inhibitor activity; 4;1;2;3;4;2;4;5;5;6;3;3;7; K04525 IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; plasma membrane Hs4502595 838.0 V [V] Defense mechanisms; P48643 T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1 - [TCPE_HUMAN] 1.407 0.935 0.931 1.113 0.796 1.044 1.504812834 nan 1.398241206 nan 0.995721925 nan 1.311557789 nan GO:0006457;GO:0009987;GO:0008150; protein folding;cellular process;biological_process; 3;2;1; GO:0043226;GO:0043229;GO:0015630;GO:0043228;GO:0044446;GO:0005832;GO:0044430;GO:0005622;GO:0044424;GO:0043234;GO:0032991;GO:0005815;GO:0043232;GO:0005829;GO:0005856;GO:0044464;GO:0005623;GO:0005737;GO:0005575;GO:0044444;GO:0044445;GO:0044422; organelle;intracellular organelle;microtubule cytoskeleton;non-membrane-bounded organelle;intracellular organelle part;chaperonin-containing T-complex;cytoskeletal part;intracellular;intracellular part;protein complex;macromolecular complex;microtubule organizing center;intracellular non-membrane-bounded organelle;cytosol;cytoskeleton;cell part;cell;cytoplasm;cellular_component;cytoplasmic part;cytosolic part;organelle part; 2;3;6;3;3;4;4;3;3;3;2;5;4;5;5;2;2;4;1;4;5;2; GO:0035639;GO:0003674;GO:0005488;GO:0000166;GO:1901363;GO:0001883;GO:0001882;GO:0043168;GO:0043167;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0031681;GO:0036094;GO:0030554;GO:0097367;GO:0097159;GO:0032559;GO:0005515;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;nucleotide binding;heterocyclic compound binding;purine nucleoside binding;nucleoside binding;anion binding;ion binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;G-protein beta-subunit binding;small molecule binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;adenyl ribonucleotide binding;protein binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;4;3;5;4;4;3;4;5;5;6;4;3;6;3;3;6;3;5;6;4; K09497 IPR002423;IPR012718;IPR017998;IPR027409;IPR027413;IPR002194; Chaperonin Cpn60/TCP-1 family;T-complex protein 1, epsilon subunit;Chaperone tailless complex polypeptide 1 (TCP-1);GroEL-like apical domain;GroEL-like equatorial domain;Chaperonin TCP-1, conserved site; cytosol Hs16159222 1109.0 O [O] Posttranslational modification, protein turnover, chaperones; P33763 Protein S100-A5 OS=Homo sapiens OX=9606 GN=S100A5 PE=1 SV=2 - [S10A5_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0097458;GO:0043025;GO:0044297;GO:0036477;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;neuron part;neuronal cell body;cell body;somatodendritic compartment;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;3;4;3;4;4;2;2;3;1;3; GO:0003674;GO:0008270;GO:0043169;GO:0046914;GO:0043167;GO:0005509;GO:0046872;GO:0042802;GO:0042803;GO:0005507;GO:0005515;GO:0046983;GO:0005488; molecular_function;zinc ion binding;cation binding;transition metal ion binding;ion binding;calcium ion binding;metal ion binding;identical protein binding;protein homodimerization activity;copper ion binding;protein binding;protein dimerization activity;binding; 1;7;4;6;3;6;5;4;5;7;3;4;2; IPR018247;IPR013787;IPR028497;IPR034325;IPR001751;IPR011992;IPR002048; EF-Hand 1, calcium-binding site;S100/CaBP-9k-type, calcium binding, subdomain;Protein S100-A5;S-100;S100/Calbindin-D9k, conserved site;EF-hand domain pair;EF-hand domain; cytosol P59665 Neutrophil defensin 1 OS=Homo sapiens OX=9606 GN=DEFA1 PE=1 SV=1 - [DEF1_HUMAN] 1.194 0.864 1 1.16 0.87 0.842 1.381944444 0.002841194 1.333333333 0.00029716 1.157407407 0.223665366 0.967816092 0.619857823 GO:0019730;GO:0019731;GO:0007165;GO:0002385;GO:0009755;GO:0051716;GO:0042330;GO:0009615;GO:0009617;GO:0001906;GO:0006935;GO:0050832;GO:0050830;GO:0030518;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0009607;GO:0009605;GO:0002376;GO:0009725;GO:0070887;GO:0042742;GO:0065007;GO:0014070;GO:0065008;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0006955;GO:0006959;GO:0051607;GO:0050896;GO:0031640;GO:0043207;GO:0023052;GO:0043401;GO:0007154;GO:0044699;GO:0009719;GO:0044364;GO:0002227;GO:0071495;GO:0009987;GO:0071396;GO:0032870;GO:0098542;GO:0071407;GO:0048545;GO:0071383;GO:0030522;GO:0030520;GO:0033993;GO:0050789;GO:0071310;GO:0045087;GO:0044763;GO:0042221;GO:0040011;GO:0009620;GO:0002251;GO:0002252;GO:0035821; antimicrobial humoral response;antibacterial humoral response;signal transduction;mucosal immune response;hormone-mediated signaling pathway;cellular response to stimulus;taxis;response to virus;response to bacterium;cell killing;chemotaxis;defense response to fungus;defense response to Gram-positive bacterium;intracellular steroid hormone receptor signaling pathway;response to other organism;response to organic substance;multi-organism process;single organism signaling;response to biotic stimulus;response to external stimulus;immune system process;response to hormone;cellular response to chemical stimulus;defense response to bacterium;biological regulation;response to organic cyclic compound;regulation of biological quality;regulation of cellular process;defense response;response to stress;biological_process;immune response;humoral immune response;defense response to virus;response to stimulus;killing of cells of other organism;response to external biotic stimulus;signaling;steroid hormone mediated signaling pathway;cell communication;single-organism process;response to endogenous stimulus;disruption of cells of other organism;innate immune response in mucosa;cellular response to endogenous stimulus;cellular process;cellular response to lipid;cellular response to hormone stimulus;defense response to other organism;cellular response to organic cyclic compound;response to steroid hormone;cellular response to steroid hormone stimulus;intracellular receptor signaling pathway;intracellular estrogen receptor signaling pathway;response to lipid;regulation of biological process;cellular response to organic substance;innate immune response;single-organism cellular process;response to chemical;locomotion;response to fungus;organ or tissue specific immune response;immune effector process;modification of morphology or physiology of other organism; 4;5;4;5;5;3;3;4;4;2;4;5;6;6;3;4;2;3;3;3;2;4;4;5;2;5;3;3;4;3;1;3;4;4;2;3;4;2;6;4;2;3;4;5;4;2;6;5;4;6;5;6;5;7;5;2;5;4;3;3;2;4;4;3;3; GO:0034774;GO:0031974;GO:0035578;GO:0031983;GO:0031982;GO:0005773;GO:0005775;GO:0031988;GO:0044437;GO:0005794;GO:0005796;GO:0099503;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0060205;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0044431;GO:0005737;GO:0030141;GO:0012505;GO:0044446;GO:0016023;GO:0044444;GO:0097708;GO:0000323;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0005764;GO:0070062;GO:0042582;GO:1903561;GO:0005615;GO:0005575;GO:0070013;GO:0005766;GO:0005576; secretory granule lumen;membrane-enclosed lumen;azurophil granule lumen;vesicle lumen;vesicle;vacuole;vacuolar lumen;membrane-bounded vesicle;vacuolar part;Golgi apparatus;Golgi lumen;secretory vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;cytoplasmic membrane-bounded vesicle lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;Golgi apparatus part;cytoplasm;secretory granule;endomembrane system;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;intracellular vesicle;lytic vacuole;cytoplasmic vesicle;cell part;cell;intracellular;lysosome;extracellular exosome;azurophil granule;extracellular vesicle;extracellular space;cellular_component;intracellular organelle lumen;primary lysosome;extracellular region; 5;2;6;4;4;5;5;5;4;4;5;6;3;4;3;3;2;2;5;3;3;2;4;4;4;4;3;3;5;4;4;6;5;2;2;3;7;4;5;3;3;1;4;8;2; K05230 IPR002366;IPR006080;IPR006081;IPR016327; Defensin propeptide;Beta/alpha defensin;Alpha-defensin;Alpha-defensin propeptide; extracellular Q5SWL8 PRAME family member 19 OS=Homo sapiens OX=9606 GN=PRAMEF19 PE=3 SV=2 - [PRA19_HUMAN] 0.957 0.965 1.25 1.04 0.84 1.339 0.991709845 nan 1.238095238 nan 1.295336788 nan 1.594047619 nan GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0007165;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0048869;GO:0010467;GO:0048518;GO:0048519;GO:0042127;GO:0060255;GO:0060548;GO:2001141;GO:0046483;GO:0044700;GO:0023057;GO:0019438;GO:0009892;GO:0009890;GO:0010629;GO:0006807;GO:0042981;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0048387;GO:0018130;GO:0050793;GO:0009889;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:1902679;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0048385;GO:0048384;GO:0044699;GO:0006139;GO:0008284;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045596;GO:0045595;GO:0045892;GO:0051093;GO:0051253;GO:0051252;GO:0043170;GO:0032502;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0008219;GO:0010941;GO:0030522;GO:2000112;GO:2000113;GO:0071704;GO:0043067;GO:0043066;GO:0043069;GO:0010468;GO:0045934;GO:0019219;GO:0006915;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007154;GO:0044238;GO:0044237;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;gene expression;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;negative regulation of cell death;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;negative regulation of signaling;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;negative regulation of gene expression;nitrogen compound metabolic process;regulation of apoptotic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;negative regulation of retinoic acid receptor signaling pathway;heterocycle biosynthetic process;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;programmed cell death;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;regulation of retinoic acid receptor signaling pathway;retinoic acid receptor signaling pathway;single-organism process;nucleobase-containing compound metabolic process;positive regulation of cell proliferation;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;negative regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;developmental process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell death;regulation of cell death;intracellular receptor signaling pathway;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell communication;primary metabolic process;cellular metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;3;4;5;4;3;4;4;4;4;5;2;2;4;4;4;6;4;3;3;5;3;4;5;3;6;2;7;4;4;2;5;5;3;4;3;5;1;2;5;5;6;5;2;6;5;6;5;6;5;4;4;2;4;5;3;4;5;6;2;4;4;3;2;4;7;7;4;4;6;3;5;5;4;2;5;5;4;4;5;4;4;5;6;6;3;5;6;5;5;5;5;6;3;3;5;3;4;4;4;3;3;3;3; IPR026271;IPR032675; PRAME family;Leucine-rich repeat domain, L domain-like; extracellular P04070 Vitamin K-dependent protein C OS=Homo sapiens OX=9606 GN=PROC PE=1 SV=1 - [PROC_HUMAN] 0.972 0.855 1.159 0.992 0.915 1.726 1.136842105 0.136197842 1.084153005 0.417544476 1.355555556 0.002996832 1.886338798 0.010037423 GO:0007599;GO:0048585;GO:0007596;GO:0048583;GO:0031348;GO:0061028;GO:0031347;GO:0050728;GO:0048869;GO:0018214;GO:0050727;GO:0018193;GO:1901552;GO:0030856;GO:0010720;GO:0030855;GO:0048518;GO:0048519;GO:0030858;GO:0002064;GO:0060548;GO:1901550;GO:0045601;GO:0016477;GO:1901564;GO:0016192;GO:0044707;GO:0019538;GO:0048870;GO:0017187;GO:0018200;GO:0002376;GO:0048468;GO:1903142;GO:0006928;GO:0006807;GO:0044267;GO:0006888;GO:0044260;GO:1900047;GO:0065007;GO:0065008;GO:0050793;GO:0006810;GO:0009888;GO:0042060;GO:0050794;GO:0006952;GO:0043412;GO:0050817;GO:0008150;GO:0008152;GO:0051234;GO:0050818;GO:0050819;GO:0046907;GO:0012501;GO:0050896;GO:0006950;GO:0036211;GO:0030195;GO:0003158;GO:0006518;GO:0032102;GO:0006954;GO:0032101;GO:0030193;GO:0030154;GO:0009611;GO:0034641;GO:1903140;GO:0044699;GO:0051241;GO:0060284;GO:0006508;GO:1903034;GO:1903035;GO:0032502;GO:0032501;GO:0050878;GO:0043687;GO:0009987;GO:0045597;GO:0045595;GO:0016485;GO:0051604;GO:0043603;GO:0051094;GO:0061041;GO:0043170;GO:0051239;GO:0051674;GO:0080134;GO:1900046;GO:0050900;GO:0061045;GO:0010467;GO:0001885;GO:0008219;GO:0010941;GO:0007275;GO:0045446;GO:0042981;GO:0050789;GO:0045603;GO:0071704;GO:0043067;GO:0043066;GO:0043069;GO:0009605;GO:0060429;GO:0048193;GO:0006915;GO:0006464;GO:0006465;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0048856;GO:0044237;GO:2000026;GO:1902582;GO:0048523;GO:0048522; hemostasis;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;negative regulation of defense response;establishment of endothelial barrier;regulation of defense response;negative regulation of inflammatory response;cellular developmental process;protein carboxylation;regulation of inflammatory response;peptidyl-amino acid modification;positive regulation of endothelial cell development;regulation of epithelial cell differentiation;positive regulation of cell development;epithelial cell differentiation;positive regulation of biological process;negative regulation of biological process;positive regulation of epithelial cell differentiation;epithelial cell development;negative regulation of cell death;regulation of endothelial cell development;regulation of endothelial cell differentiation;cell migration;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;cell motility;peptidyl-glutamic acid carboxylation;peptidyl-glutamic acid modification;immune system process;cell development;positive regulation of establishment of endothelial barrier;movement of cell or subcellular component;nitrogen compound metabolic process;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;negative regulation of hemostasis;biological regulation;regulation of biological quality;regulation of developmental process;transport;tissue development;wound healing;regulation of cellular process;defense response;macromolecule modification;coagulation;biological_process;metabolic process;establishment of localization;regulation of coagulation;negative regulation of coagulation;intracellular transport;programmed cell death;response to stimulus;response to stress;protein modification process;negative regulation of blood coagulation;endothelium development;peptide metabolic process;negative regulation of response to external stimulus;inflammatory response;regulation of response to external stimulus;regulation of blood coagulation;cell differentiation;response to wounding;cellular nitrogen compound metabolic process;regulation of establishment of endothelial barrier;single-organism process;negative regulation of multicellular organismal process;regulation of cell development;proteolysis;regulation of response to wounding;negative regulation of response to wounding;developmental process;multicellular organismal process;regulation of body fluid levels;post-translational protein modification;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;protein processing;protein maturation;cellular amide metabolic process;positive regulation of developmental process;regulation of wound healing;macromolecule metabolic process;regulation of multicellular organismal process;localization of cell;regulation of response to stress;regulation of hemostasis;leukocyte migration;negative regulation of wound healing;gene expression;endothelial cell development;cell death;regulation of cell death;multicellular organism development;endothelial cell differentiation;regulation of apoptotic process;regulation of biological process;positive regulation of endothelial cell differentiation;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;response to external stimulus;epithelium development;Golgi vesicle transport;apoptotic process;cellular protein modification process;signal peptide processing;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;locomotion;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of multicellular organismal development;single-organism intracellular transport;negative regulation of cellular process;positive regulation of cellular process; 5;3;5;3;4;7;5;5;4;7;5;7;6;5;5;6;2;2;5;5;4;6;6;4;4;5;3;4;3;8;8;2;4;7;4;3;5;7;4;4;2;3;3;4;4;5;3;4;5;4;1;2;3;4;4;5;5;2;3;5;5;6;5;4;5;4;5;5;4;4;7;2;3;5;5;5;4;2;2;4;7;2;4;4;6;5;5;3;6;4;3;3;4;4;3;5;5;6;4;4;4;7;6;2;6;3;5;6;5;3;5;6;6;6;6;3;4;3;4;2;3;3;2;3;3;3;4;5;3;3; GO:0005783;GO:0031974;GO:0005576;GO:0005794;GO:0005796;GO:0005788;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005615;GO:0005575;GO:0070013; endoplasmic reticulum;membrane-enclosed lumen;extracellular region;Golgi apparatus;Golgi lumen;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;extracellular space;cellular_component;intracellular organelle lumen; 4;2;2;4;5;5;4;3;3;2;2;3;3;3;2;4;4;3;3;4;4;2;2;3;1;4; GO:0004252;GO:0046872;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0005509;GO:0004175;GO:0070011; serine-type endopeptidase activity;metal ion binding;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;cation binding;ion binding;calcium ion binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;5;4;1;2;3;2;4;5;4;3;6;6;5; K01344 map04610; Complement and coagulation cascades; IPR000152;IPR018097;IPR001254;IPR000742;IPR017857;IPR009003;IPR000294;IPR018114;IPR001881;IPR013032;IPR033116;IPR001314; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;EGF-like domain;Coagulation factor, subgroup, Gla domain;Peptidase S1, PA clan;Gamma-carboxyglutamic acid-rich (GLA) domain;Serine proteases, trypsin family, histidine active site;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular 159897046 175.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease Q9BX26 Synaptonemal complex protein 2 OS=Homo sapiens OX=9606 GN=SYCP2 PE=2 SV=2 - [SYCP2_HUMAN] 0.917 0.953 1.308 1.176 0.912 0.656 0.962224554 nan 1.289473684 nan 1.37250787 nan 0.719298246 nan GO:0071840;GO:0007130;GO:0000003;GO:0045132;GO:0048513;GO:0065007;GO:0060548;GO:0051704;GO:0044703;GO:0044702;GO:0043069;GO:0009566;GO:0044707;GO:0016043;GO:0048806;GO:0007049;GO:0048808;GO:0009887;GO:0050794;GO:0012501;GO:0008150;GO:0007059;GO:0046661;GO:0007548;GO:0070193;GO:0070192;GO:0019953;GO:0022607;GO:0009653;GO:0044699;GO:0007126;GO:0007127;GO:0051321;GO:0000280;GO:0007129;GO:0032502;GO:0032501;GO:0048608;GO:0009987;GO:0048519;GO:0007143;GO:0045143;GO:0098813;GO:0048731;GO:0061458;GO:1903046;GO:0022402;GO:0008219;GO:0010941;GO:0007275;GO:0007140;GO:0042981;GO:0050789;GO:0090598;GO:0043067;GO:0043066;GO:0051301;GO:0006915;GO:0044767;GO:0022414;GO:0044763;GO:0035112;GO:0006996;GO:0051276;GO:0003006;GO:0048856;GO:0030539;GO:1902589;GO:0044085;GO:0048285;GO:0048523; cellular component organization or biogenesis;synaptonemal complex assembly;reproduction;meiotic chromosome segregation;animal organ development;biological regulation;negative regulation of cell death;multi-organism process;multi-organism reproductive process;single organism reproductive process;negative regulation of programmed cell death;fertilization;single-multicellular organism process;cellular component organization;genitalia development;cell cycle;male genitalia morphogenesis;organ morphogenesis;regulation of cellular process;programmed cell death;biological_process;chromosome segregation;male sex differentiation;sex differentiation;synaptonemal complex organization;chromosome organization involved in meiotic cell cycle;sexual reproduction;cellular component assembly;anatomical structure morphogenesis;single-organism process;meiotic nuclear division;meiosis I;meiotic cell cycle;nuclear division;synapsis;developmental process;multicellular organismal process;reproductive structure development;cellular process;negative regulation of biological process;female meiotic division;homologous chromosome segregation;nuclear chromosome segregation;system development;reproductive system development;meiotic cell cycle process;cell cycle process;cell death;regulation of cell death;multicellular organism development;male meiosis;regulation of apoptotic process;regulation of biological process;male anatomical structure morphogenesis;regulation of programmed cell death;negative regulation of apoptotic process;cell division;apoptotic process;single-organism developmental process;reproductive process;single-organism cellular process;genitalia morphogenesis;organelle organization;chromosome organization;developmental process involved in reproduction;anatomical structure development;male genitalia development;single-organism organelle organization;cellular component biogenesis;organelle fission;negative regulation of cellular process; 2;5;2;5;4;2;4;2;3;3;5;4;3;3;4;4;5;4;3;5;1;4;5;4;6;4;3;4;3;2;4;5;3;6;5;2;2;4;2;2;5;6;5;4;5;4;4;4;4;4;5;6;2;4;5;6;4;6;3;2;3;4;4;5;3;3;5;4;3;5;3; GO:0031974;GO:0031981;GO:0000793;GO:0000794;GO:0000795;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0043228;GO:0000228;GO:0043227;GO:0043226;GO:0044446;GO:0005634;GO:0000800;GO:0044454;GO:0044464;GO:0005623;GO:0005622;GO:0005694;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;condensed chromosome;condensed nuclear chromosome;synaptonemal complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome;membrane-bounded organelle;organelle;intracellular organelle part;nucleus;lateral element;nuclear chromosome part;cell part;cell;intracellular;chromosome;cellular_component;intracellular organelle lumen; 2;5;6;6;6;4;4;3;4;3;4;2;3;3;5;3;2;3;5;6;5;2;2;3;5;1;4; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding; 3;1;2;4;5;3; K19529 IPR024835;IPR024832; Synaptonemal complex protein 1/2;Synaptonemal complex protein 2; nucleus Q75V66 Anoctamin-5 OS=Homo sapiens OX=9606 GN=ANO5 PE=1 SV=1 - [ANO5_HUMAN] 0.846 0.966 0.853 1.563 0.958 0.89 0.875776398 0.688295957 1.631524008 0.426051053 0.883022774 0.486631318 0.929018789 0.739566514 GO:0006820;GO:0006821;GO:0006811;GO:0044699;GO:0051179;GO:1902476;GO:0006810;GO:0098661;GO:0009987;GO:0034220;GO:0044765;GO:0044763;GO:0015698;GO:0051234;GO:0055085;GO:1902578;GO:0098660;GO:0098656;GO:0008150; anion transport;chloride transport;ion transport;single-organism process;localization;chloride transmembrane transport;transport;inorganic anion transmembrane transport;cellular process;ion transmembrane transport;single-organism transport;single-organism cellular process;inorganic anion transport;establishment of localization;transmembrane transport;single-organism localization;inorganic ion transmembrane transport;anion transmembrane transport;biological_process; 6;8;5;2;2;8;4;7;2;5;4;3;7;3;4;3;6;6;1; GO:0098588;GO:0005783;GO:0005886;GO:0005789;GO:0042175;GO:0044424;GO:0043227;GO:0043226;GO:0005737;GO:0031982;GO:0016020;GO:0044444;GO:0044425;GO:0044432;GO:0031224;GO:0043229;GO:0071944;GO:0044446;GO:0012505;GO:0031090;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0016021;GO:0044422; bounding membrane of organelle;endoplasmic reticulum;plasma membrane;endoplasmic reticulum membrane;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular part;membrane-bounded organelle;organelle;cytoplasm;vesicle;membrane;cytoplasmic part;membrane part;endoplasmic reticulum part;intrinsic component of membrane;intracellular organelle;cell periphery;intracellular organelle part;endomembrane system;organelle membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;integral component of membrane;organelle part; 4;4;3;3;3;3;3;2;4;4;2;4;2;4;3;3;3;3;3;3;4;2;2;3;1;4;2; GO:0005229;GO:0003674;GO:0015075;GO:0008509;GO:0015103;GO:0022803;GO:0005253;GO:0005254;GO:0015108;GO:0005215;GO:0005216;GO:0022891;GO:0022892;GO:0022857;GO:0015267;GO:0022836;GO:0022839;GO:0022838; intracellular calcium activated chloride channel activity;molecular_function;ion transmembrane transporter activity;anion transmembrane transporter activity;inorganic anion transmembrane transporter activity;passive transmembrane transporter activity;anion channel activity;chloride channel activity;chloride transmembrane transporter activity;transporter activity;ion channel activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;transmembrane transporter activity;channel activity;gated channel activity;ion gated channel activity;substrate-specific channel activity; 8;1;5;6;7;4;7;8;8;2;6;4;3;3;5;6;7;5; K19480 IPR031294;IPR007632;IPR032394; Anoctamin-5;Anoctamin;Anoctamin, dimerisation domain; plasma membrane Hs20480633 1715.0 S [S] Function unknown; P13994 Coiled-coil domain-containing protein 130 OS=Homo sapiens OX=9606 GN=CCDC130 PE=1 SV=2 - [CC130_HUMAN] 0.926 0.847 1.309 1.047 1.056 0.832 1.093270366 nan 0.991477273 nan 1.545454545 nan 0.787878788 nan GO:0009607;GO:0009605;GO:0043207;GO:0009615;GO:0050896;GO:0008150;GO:0051707;GO:0051704; response to biotic stimulus;response to external stimulus;response to external biotic stimulus;response to virus;response to stimulus;biological_process;response to other organism;multi-organism process; 3;3;4;4;2;1;3;2; K13115 IPR007590; CWC16 protein; nucleus Hs13540614 827.0 S [S] Function unknown; Q9BYX2 TBC1 domain family member 2A OS=Homo sapiens OX=9606 GN=TBC1D2 PE=1 SV=3 - [TBD2A_HUMAN] 1.198 0.952 0.897 0.917 1.176 1.137 1.258403361 nan 0.779761905 nan 0.942226891 nan 0.966836735 nan GO:0043087;GO:0043085;GO:0043547;GO:0051345;GO:0065007;GO:0044093;GO:0065009;GO:0050790;GO:0008150;GO:0051336; regulation of GTPase activity;positive regulation of catalytic activity;positive regulation of GTPase activity;positive regulation of hydrolase activity;biological regulation;positive regulation of molecular function;regulation of molecular function;regulation of catalytic activity;biological_process;regulation of hydrolase activity; 6;5;7;6;2;4;3;4;1;5; GO:0043229;GO:0043226;GO:0005737;GO:0016023;GO:0031410;GO:0031988;GO:0030054;GO:0097708;GO:0043227;GO:0031982;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; intracellular organelle;organelle;cytoplasm;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;membrane-bounded vesicle;cell junction;intracellular vesicle;membrane-bounded organelle;vesicle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 3;2;4;5;5;5;2;4;3;4;4;2;2;3;1;4;3; GO:0003674;GO:0008047;GO:0045296;GO:0098772;GO:0030234;GO:0005096;GO:0030695;GO:0050839;GO:0060589;GO:0005515;GO:0005488; molecular_function;enzyme activator activity;cadherin binding;molecular function regulator;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;cell adhesion molecule binding;nucleoside-triphosphatase regulator activity;protein binding;binding; 1;4;5;2;3;5;5;4;4;3;2; K20165 IPR000195;IPR001849;IPR011993; Rab-GTPase-TBC domain;Pleckstrin homology domain;PH domain-like; cytosol Hs8922167 967.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3 - [FTO_HUMAN] 0.862 0.771 0.865 0.833 0.884 4.404 1.118028534 nan 0.942307692 nan 1.121919585 nan 4.981900452 nan GO:0048589;GO:0009451;GO:0035264;GO:0019915;GO:0044707;GO:1901360;GO:0006307;GO:0051716;GO:0006304;GO:0048869;GO:0048513;GO:0046483;GO:0042127;GO:0070344;GO:0070343;GO:0006281;GO:0010876;GO:0055114;GO:0003008;GO:0070988;GO:0070989;GO:0048871;GO:0033554;GO:0033036;GO:0003016;GO:0006807;GO:0035552;GO:0035553;GO:0044260;GO:0065007;GO:0010883;GO:0065008;GO:0050793;GO:0044710;GO:0050794;GO:0043412;GO:0044728;GO:0008150;GO:0051239;GO:0051235;GO:0016070;GO:0050896;GO:0006950;GO:0048638;GO:0008152;GO:0030154;GO:0034641;GO:0060612;GO:0044699;GO:0070350;GO:0006139;GO:0044057;GO:0042592;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:0050873;GO:0006974;GO:0045595;GO:0090335;GO:0001659;GO:0032879;GO:0043576;GO:0045598;GO:0044065;GO:0043170;GO:0048731;GO:0042245;GO:0035510;GO:0035511;GO:0035513;GO:0090304;GO:0045444;GO:0007275;GO:0009888;GO:0040007;GO:0040008;GO:0070341;GO:0050789;GO:0071704;GO:0007585;GO:0061448;GO:0044767;GO:0044763;GO:0051179;GO:0044238;GO:0040014;GO:0048856;GO:0044237;GO:0080111;GO:0006259; developmental growth;RNA modification;multicellular organism growth;lipid storage;single-multicellular organism process;organic cyclic compound metabolic process;DNA dealkylation involved in DNA repair;cellular response to stimulus;DNA modification;cellular developmental process;animal organ development;heterocycle metabolic process;regulation of cell proliferation;regulation of fat cell proliferation;white fat cell proliferation;DNA repair;lipid localization;oxidation-reduction process;system process;demethylation;oxidative demethylation;multicellular organismal homeostasis;cellular response to stress;macromolecule localization;respiratory system process;nitrogen compound metabolic process;oxidative single-stranded DNA demethylation;oxidative single-stranded RNA demethylation;cellular macromolecule metabolic process;biological regulation;regulation of lipid storage;regulation of biological quality;regulation of developmental process;single-organism metabolic process;regulation of cellular process;macromolecule modification;DNA methylation or demethylation;biological_process;regulation of multicellular organismal process;maintenance of location;RNA metabolic process;response to stimulus;response to stress;regulation of developmental growth;metabolic process;cell differentiation;cellular nitrogen compound metabolic process;adipose tissue development;single-organism process;regulation of white fat cell proliferation;nucleobase-containing compound metabolic process;regulation of system process;homeostatic process;developmental process;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;brown fat cell differentiation;cellular response to DNA damage stimulus;regulation of cell differentiation;regulation of brown fat cell differentiation;temperature homeostasis;regulation of localization;regulation of respiratory gaseous exchange;regulation of fat cell differentiation;regulation of respiratory system process;macromolecule metabolic process;system development;RNA repair;DNA dealkylation;oxidative DNA demethylation;oxidative RNA demethylation;nucleic acid metabolic process;fat cell differentiation;multicellular organism development;tissue development;growth;regulation of growth;fat cell proliferation;regulation of biological process;organic substance metabolic process;respiratory gaseous exchange;connective tissue development;single-organism developmental process;single-organism cellular process;localization;primary metabolic process;regulation of multicellular organism growth;anatomical structure development;cellular metabolic process;DNA demethylation;DNA metabolic process; 3;6;4;4;3;4;5;3;6;4;4;4;4;5;5;4;4;4;3;4;5;4;4;3;4;3;6;5;4;2;4;3;3;3;3;5;7;1;3;3;5;2;3;4;2;5;4;5;2;6;4;4;4;2;2;3;2;4;7;5;4;6;5;3;4;5;5;4;4;6;7;5;4;5;6;4;4;2;3;4;2;3;4;5;3;3;2;3;4;3;3;4;5; GO:0031974;GO:0031981;GO:0043233;GO:0043231;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0005654;GO:0044446;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;organelle lumen;intracellular membrane-bounded organelle;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;nucleoplasm;intracellular organelle part;nucleus;nucleoplasm part;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;3;4;4;3;2;3;3;3;2;7;6;5;3;5;5;2;2;1;4; GO:0016491;GO:0051213;GO:0003674;GO:0005488;GO:0043169;GO:0003824;GO:0008198;GO:0016706;GO:0016705;GO:0043167;GO:0005506;GO:0046872;GO:0035514;GO:0035515;GO:0035516;GO:0032451;GO:0043734;GO:0046914; oxidoreductase activity;dioxygenase activity;molecular_function;binding;cation binding;catalytic activity;ferrous iron binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;ion binding;iron ion binding;metal ion binding;DNA demethylase activity;oxidative RNA demethylase activity;oxidative DNA demethylase activity;demethylase activity;DNA-N1-methyladenine dioxygenase activity;transition metal ion binding; 3;4;1;2;4;2;8;5;4;3;7;5;4;4;4;3;6;6; K19469 IPR024367;IPR024366;IPR032868;IPR027450; Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain;Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal;Alpha-ketoglutarate-dependent dioxygenase FTO;Alpha-ketoglutarate-dependent dioxygenase AlkB-like; cytosol Q01973 Inactive tyrosine-protein kinase transmembrane receptor ROR1 OS=Homo sapiens OX=9606 GN=ROR1 PE=1 SV=2 - [ROR1_HUMAN] 0.91 0.933 1.362 0.961 0.881 1.234 0.975348339 nan 1.090805902 nan 1.459807074 nan 1.400681044 nan GO:0007164;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0051716;GO:0018212;GO:0018193;GO:0048513;GO:0035567;GO:0044700;GO:0090175;GO:0044707;GO:0019538;GO:0016055;GO:0022603;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0009887;GO:0050793;GO:0009888;GO:0050794;GO:0060071;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0050896;GO:0051239;GO:0016310;GO:0023052;GO:0009653;GO:0044699;GO:0032502;GO:0032501;GO:0060429;GO:0043170;GO:0048731;GO:0018108;GO:0007275;GO:0002009;GO:0006796;GO:0071704;GO:0048729;GO:0006468;GO:0009987;GO:0006464;GO:0044767;GO:0001738;GO:0044763;GO:0007154;GO:0001736;GO:0044238;GO:0048856;GO:0044237;GO:2000026;GO:2000027;GO:0006793; establishment of tissue polarity;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular response to stimulus;peptidyl-tyrosine modification;peptidyl-amino acid modification;animal organ development;non-canonical Wnt signaling pathway;single organism signaling;regulation of establishment of planar polarity;single-multicellular organism process;protein metabolic process;Wnt signaling pathway;regulation of anatomical structure morphogenesis;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;organ morphogenesis;regulation of developmental process;tissue development;regulation of cellular process;Wnt signaling pathway, planar cell polarity pathway;macromolecule modification;protein modification process;biological_process;metabolic process;response to stimulus;regulation of multicellular organismal process;phosphorylation;signaling;anatomical structure morphogenesis;single-organism process;developmental process;multicellular organismal process;epithelium development;macromolecule metabolic process;system development;peptidyl-tyrosine phosphorylation;multicellular organism development;morphogenesis of an epithelium;phosphate-containing compound metabolic process;organic substance metabolic process;tissue morphogenesis;protein phosphorylation;cellular process;cellular protein modification process;single-organism developmental process;morphogenesis of a polarized epithelium;single-organism cellular process;cell communication;establishment of planar polarity;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of multicellular organismal development;regulation of organ morphogenesis;phosphorus metabolic process; 4;4;5;6;7;3;8;7;4;7;3;6;3;4;6;4;2;5;4;2;4;3;4;3;7;5;5;1;2;2;3;6;2;3;2;2;2;5;4;4;8;4;5;5;3;4;7;2;6;3;6;3;4;5;3;3;3;4;5;4; GO:0016021;GO:0016020;GO:0043235;GO:0043234;GO:0044424;GO:0044425;GO:0005622;GO:0031224;GO:0031226;GO:0005737;GO:0044459;GO:0032991;GO:0044464;GO:0005623;GO:0071944;GO:0005887;GO:0005886;GO:0005575; integral component of membrane;membrane;receptor complex;protein complex;intracellular part;membrane part;intracellular;intrinsic component of membrane;intrinsic component of plasma membrane;cytoplasm;plasma membrane part;macromolecular complex;cell part;cell;cell periphery;integral component of plasma membrane;plasma membrane;cellular_component; 4;2;4;3;3;2;3;3;4;4;3;2;2;2;3;4;3;1; GO:0060089;GO:1901363;GO:0000166;GO:0004714;GO:0004713;GO:0097367;GO:0099600;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:1904929;GO:0016301;GO:0003824;GO:0036094;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0016740;GO:0043167;GO:0030554;GO:0005515;GO:0097159;GO:0017147;GO:0038023;GO:0004872;GO:0004871;GO:0001883;GO:0001882;GO:0004672;GO:0015026;GO:0071936;GO:0004888;GO:0019199; molecular transducer activity;heterocyclic compound binding;nucleotide binding;transmembrane receptor protein tyrosine kinase activity;protein tyrosine kinase activity;carbohydrate derivative binding;transmembrane receptor activity;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;kinase activity;catalytic activity;small molecule binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;transferase activity;ion binding;adenyl nucleotide binding;protein binding;organic cyclic compound binding;Wnt-protein binding;signaling receptor activity;receptor activity;signal transducer activity;purine nucleoside binding;nucleoside binding;protein kinase activity;coreceptor activity;coreceptor activity involved in Wnt signaling pathway;transmembrane signaling receptor activity;transmembrane receptor protein kinase activity; 2;3;4;6;7;3;4;1;2;4;5;5;6;4;6;5;2;3;5;4;6;5;6;4;5;3;3;6;3;3;4;3;3;2;5;4;6;4;5;4;5; K05122 IPR003599;IPR003598;IPR013783;IPR011009;IPR018056;IPR007110;IPR008266;IPR001245;IPR000719;IPR016247;IPR020067;IPR000001;IPR013806;IPR013098; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;Protein kinase-like domain;Kringle, conserved site;Immunoglobulin-like domain;Tyrosine-protein kinase, active site;Serine-threonine/tyrosine-protein kinase, catalytic domain;Protein kinase domain;Tyrosine-protein kinase, receptor ROR;Frizzled domain;Kringle;Kringle-like fold;Immunoglobulin I-set; plasma membrane Hs4826868 1953.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q9ULB5 Cadherin-7 OS=Homo sapiens OX=9606 GN=CDH7 PE=2 SV=2 - [CADH7_HUMAN] 0.804 0.953 1.544 1.137 0.713 0.888 0.843651626 nan 1.594670407 nan 1.620146905 nan 1.245441795 nan GO:0022607;GO:0016337;GO:0034332;GO:0034330;GO:0016043;GO:0071840;GO:0022610;GO:0098602;GO:0098609;GO:0009987;GO:0008150;GO:0045216;GO:0007155;GO:0007156;GO:0034329;GO:0098742;GO:0044699;GO:0044763;GO:0044085; cellular component assembly;single organismal cell-cell adhesion;adherens junction organization;cell junction organization;cellular component organization;cellular component organization or biogenesis;biological adhesion;single organism cell adhesion;cell-cell adhesion;cellular process;biological_process;cell-cell junction organization;cell adhesion;homophilic cell adhesion via plasma membrane adhesion molecules;cell junction assembly;cell-cell adhesion via plasma-membrane adhesion molecules;single-organism process;single-organism cellular process;cellular component biogenesis; 4;4;6;4;3;2;2;3;4;2;1;5;3;6;5;5;2;3;3; GO:0071944;GO:0031224;GO:0016021;GO:0016020;GO:0044464;GO:0005886;GO:0005623;GO:0005575;GO:0044425; cell periphery;intrinsic component of membrane;integral component of membrane;membrane;cell part;plasma membrane;cell;cellular_component;membrane part; 3;3;4;2;2;3;2;1;2; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding; 1;2;4;3;6;5; K06799 IPR002126;IPR000233;IPR020894;IPR015919;IPR027397; Cadherin;Cadherin, cytoplasmic domain;Cadherin conserved site;Cadherin-like;Catenin binding domain; endoplasmic reticulum Hs16306487 1617.0 S [S] Function unknown; Q6ZNW5 GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2 - [GDPP1_HUMAN] 0.787 0.684 1.946 0.87 0.78 0.68 1.150584795 nan 1.115384615 nan 2.84502924 nan 0.871794872 nan GO:0005996;GO:0044710;GO:0071704;GO:0044699;GO:0019318;GO:0008150;GO:0008152;GO:0044723;GO:0044238;GO:0005975;GO:0006006;GO:0044281; monosaccharide metabolic process;single-organism metabolic process;organic substance metabolic process;single-organism process;hexose metabolic process;biological_process;metabolic process;single-organism carbohydrate metabolic process;primary metabolic process;carbohydrate metabolic process;glucose metabolic process;small molecule metabolic process; 5;3;3;2;6;1;2;4;3;4;7;4; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0005085;GO:0003674;GO:0005488;GO:0098772;GO:1901363;GO:1901265;GO:0000166;GO:0016740;GO:0080048;GO:0016787;GO:0036094;GO:0003824;GO:0016779;GO:0016772;GO:0004645;GO:0016757;GO:0097159;GO:0016758; guanyl-nucleotide exchange factor activity;molecular_function;binding;molecular function regulator;heterocyclic compound binding;nucleoside phosphate binding;nucleotide binding;transferase activity;GDP-D-glucose phosphorylase activity;hydrolase activity;small molecule binding;catalytic activity;nucleotidyltransferase activity;transferase activity, transferring phosphorus-containing groups;phosphorylase activity;transferase activity, transferring glycosyl groups;organic cyclic compound binding;transferase activity, transferring hexosyl groups; 3;1;2;2;3;4;4;3;7;3;3;2;5;4;6;4;3;5; K15630 IPR026506; GDP-L-galactose/GDP-D-glucose phosphorylase; cytosol At5g55120 157.0 R [R] General function prediction only; Q96PC2 Inositol hexakisphosphate kinase 3 OS=Homo sapiens OX=9606 GN=IP6K3 PE=1 SV=2 - [IP6K3_HUMAN] 1.121 1.413 0.644 0.929 1.335 0.333 0.793347488 0.057196847 0.69588015 0.050681005 0.45576787 0.012038909 0.249438202 0.004113794 GO:0044281;GO:0044283;GO:0044710;GO:0044711;GO:0046488;GO:0046486;GO:0043647;GO:0019538;GO:0019637;GO:0044267;GO:0044260;GO:0006629;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0032958;GO:0090407;GO:1901615;GO:0016310;GO:0046173;GO:0044699;GO:0006644;GO:0046165;GO:0009987;GO:0044255;GO:0043170;GO:0006650;GO:0019751;GO:0006066;GO:0071704;GO:0006468;GO:1901576;GO:0006464;GO:0009058;GO:0044763;GO:0044238;GO:0044237;GO:1901617;GO:0006796;GO:0006793; small molecule metabolic process;small molecule biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;phosphatidylinositol metabolic process;glycerolipid metabolic process;inositol phosphate metabolic process;protein metabolic process;organophosphate metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;lipid metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;inositol phosphate biosynthetic process;organophosphate biosynthetic process;organic hydroxy compound metabolic process;phosphorylation;polyol biosynthetic process;single-organism process;phospholipid metabolic process;alcohol biosynthetic process;cellular process;cellular lipid metabolic process;macromolecule metabolic process;glycerophospholipid metabolic process;polyol metabolic process;alcohol metabolic process;organic substance metabolic process;protein phosphorylation;organic substance biosynthetic process;cellular protein modification process;biosynthetic process;single-organism cellular process;primary metabolic process;cellular metabolic process;organic hydroxy compound biosynthetic process;phosphate-containing compound metabolic process;phosphorus metabolic process; 4;5;3;4;7;5;4;4;4;5;4;4;5;5;1;2;5;5;4;6;7;2;5;6;2;4;4;6;6;5;3;7;4;6;3;3;3;3;5;5;4; GO:0043231;GO:0005829;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0044424;GO:0005575; intracellular membrane-bounded organelle;cytosol;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasmic part;cytoplasm;nucleus;cell part;cell;intracellular part;cellular_component; 4;5;3;3;3;2;4;4;5;2;2;3;1; GO:1901363;GO:0000166;GO:0016740;GO:0052723;GO:0052724;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0051766;GO:0016773;GO:0016772;GO:0016776;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0097159;GO:0001883;GO:0001882;GO:0008440;GO:0000828;GO:0036094;GO:0000832;GO:0000831; heterocyclic compound binding;nucleotide binding;transferase activity;inositol hexakisphosphate 1-kinase activity;inositol hexakisphosphate 3-kinase activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;kinase activity;catalytic activity;inositol trisphosphate kinase activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;phosphotransferase activity, phosphate group as acceptor;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;inositol-1,4,5-trisphosphate 3-kinase activity;inositol hexakisphosphate kinase activity;small molecule binding;inositol hexakisphosphate 5-kinase activity;inositol hexakisphosphate 6-kinase activity; 3;4;3;7;7;3;1;2;4;5;5;6;4;5;2;6;5;4;5;6;5;6;4;5;3;6;3;5;4;7;6;3;7;7; K07756 map04070; Phosphatidylinositol signaling system; IPR005522; Inositol polyphosphate kinase; nucleus Hs16905371 600.0 KIT [K] Transcription;[I] Lipid transport and metabolism;[T] Signal transduction mechanisms; Q9C0H9 SRC kinase signaling inhibitor 1 OS=Homo sapiens OX=9606 GN=SRCIN1 PE=1 SV=4 - [SRCN1_HUMAN] 1.227 1.372 0.657 1.007 1.135 0.521 0.894314869 nan 0.88722467 nan 0.478862974 nan 0.459030837 nan GO:0008104;GO:0019220;GO:0080090;GO:0051046;GO:0034446;GO:0051048;GO:0051049;GO:0048468;GO:0016358;GO:0032989;GO:0044707;GO:0071840;GO:0097061;GO:0010605;GO:0019222;GO:0071704;GO:0048869;GO:0018212;GO:0018193;GO:0045664;GO:0060998;GO:0044093;GO:0044092;GO:0048518;GO:0048519;GO:0033036;GO:0060996;GO:0060997;GO:0031589;GO:0051051;GO:0060255;GO:0032268;GO:0010975;GO:0042325;GO:0042327;GO:0042326;GO:0016192;GO:0048870;GO:0019538;GO:0050730;GO:0050732;GO:0050731;GO:0022604;GO:0009892;GO:0009893;GO:0022603;GO:0061001;GO:0006928;GO:0032940;GO:0031175;GO:0051223;GO:0051224;GO:0050789;GO:0044267;GO:0000904;GO:0050708;GO:0000902;GO:0044260;GO:0006887;GO:0016043;GO:0031344;GO:0050793;GO:0065007;GO:0043085;GO:0061097;GO:0061098;GO:0061099;GO:0065009;GO:0016477;GO:0070201;GO:0098602;GO:0009306;GO:0006810;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0051348;GO:0051239;GO:0051234;GO:0010604;GO:0051174;GO:0046903;GO:0045859;GO:0031400;GO:0031401;GO:0051338;GO:0048813;GO:0051960;GO:2000145;GO:0048814;GO:0033673;GO:0010563;GO:0008152;GO:0016310;GO:0030154;GO:0051128;GO:1903531;GO:1903530;GO:1904950;GO:0009653;GO:0043086;GO:0044699;GO:0032880;GO:0050767;GO:0051248;GO:0010562;GO:0033674;GO:0051246;GO:0051247;GO:0060284;GO:0032270;GO:0043549;GO:0031399;GO:0051641;GO:0050790;GO:0032502;GO:0032501;GO:0051347;GO:0044238;GO:0009987;GO:0045595;GO:0051270;GO:0018108;GO:0032879;GO:0032990;GO:0032269;GO:0022610;GO:0050773;GO:0051674;GO:0048731;GO:0045860;GO:0060341;GO:0030030;GO:0031325;GO:0031324;GO:0031323;GO:0043170;GO:0006469;GO:0045937;GO:0007275;GO:0048812;GO:0071702;GO:0048666;GO:0048667;GO:0006468;GO:0030334;GO:0030182;GO:0045936;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0007155;GO:0010769;GO:0022008;GO:0051179;GO:1902578;GO:0050709;GO:0040011;GO:0045184;GO:0048699;GO:0040012;GO:0048858;GO:0007399;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:0006793;GO:0015031;GO:0001933;GO:0001932;GO:0001934;GO:0048523;GO:0048522; protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of secretion;substrate adhesion-dependent cell spreading;negative regulation of secretion;regulation of transport;cell development;dendrite development;cellular component morphogenesis;single-multicellular organism process;cellular component organization or biogenesis;dendritic spine organization;negative regulation of macromolecule metabolic process;regulation of metabolic process;organic substance metabolic process;cellular developmental process;peptidyl-tyrosine modification;peptidyl-amino acid modification;regulation of neuron differentiation;regulation of dendritic spine development;positive regulation of molecular function;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;macromolecule localization;dendritic spine development;dendritic spine morphogenesis;cell-substrate adhesion;negative regulation of transport;regulation of macromolecule metabolic process;regulation of cellular protein metabolic process;regulation of neuron projection development;regulation of phosphorylation;positive regulation of phosphorylation;negative regulation of phosphorylation;vesicle-mediated transport;cell motility;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;negative regulation of peptidyl-tyrosine phosphorylation;positive regulation of peptidyl-tyrosine phosphorylation;regulation of cell morphogenesis;negative regulation of metabolic process;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;regulation of dendritic spine morphogenesis;movement of cell or subcellular component;secretion by cell;neuron projection development;regulation of protein transport;negative regulation of protein transport;regulation of biological process;cellular protein metabolic process;cell morphogenesis involved in differentiation;regulation of protein secretion;cell morphogenesis;cellular macromolecule metabolic process;exocytosis;cellular component organization;regulation of cell projection organization;regulation of developmental process;biological regulation;positive regulation of catalytic activity;regulation of protein tyrosine kinase activity;positive regulation of protein tyrosine kinase activity;negative regulation of protein tyrosine kinase activity;regulation of molecular function;cell migration;regulation of establishment of protein localization;single organism cell adhesion;protein secretion;transport;regulation of cellular process;macromolecule modification;protein modification process;biological_process;negative regulation of transferase activity;regulation of multicellular organismal process;establishment of localization;positive regulation of macromolecule metabolic process;regulation of phosphorus metabolic process;secretion;regulation of protein kinase activity;negative regulation of protein modification process;positive regulation of protein modification process;regulation of transferase activity;dendrite morphogenesis;regulation of nervous system development;regulation of cell motility;regulation of dendrite morphogenesis;negative regulation of kinase activity;negative regulation of phosphorus metabolic process;metabolic process;phosphorylation;cell differentiation;regulation of cellular component organization;negative regulation of secretion by cell;regulation of secretion by cell;negative regulation of establishment of protein localization;anatomical structure morphogenesis;negative regulation of catalytic activity;single-organism process;regulation of protein localization;regulation of neurogenesis;negative regulation of protein metabolic process;positive regulation of phosphorus metabolic process;positive regulation of kinase activity;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell development;positive regulation of cellular protein metabolic process;regulation of kinase activity;regulation of protein modification process;cellular localization;regulation of catalytic activity;developmental process;multicellular organismal process;positive regulation of transferase activity;primary metabolic process;cellular process;regulation of cell differentiation;regulation of cellular component movement;peptidyl-tyrosine phosphorylation;regulation of localization;cell part morphogenesis;negative regulation of cellular protein metabolic process;biological adhesion;regulation of dendrite development;localization of cell;system development;positive regulation of protein kinase activity;regulation of cellular localization;cell projection organization;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;macromolecule metabolic process;negative regulation of protein kinase activity;positive regulation of phosphate metabolic process;multicellular organism development;neuron projection morphogenesis;organic substance transport;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;regulation of cell migration;neuron differentiation;negative regulation of phosphate metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;cell adhesion;regulation of cell morphogenesis involved in differentiation;neurogenesis;localization;single-organism localization;negative regulation of protein secretion;locomotion;establishment of protein localization;generation of neurons;regulation of locomotion;cell projection morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;protein transport;negative regulation of protein phosphorylation;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 4;6;4;5;4;4;4;4;4;4;3;2;5;4;3;3;4;8;7;7;5;4;4;2;2;3;4;5;4;3;4;5;6;7;7;7;5;3;4;8;8;8;5;3;3;4;6;4;4;5;5;4;2;5;5;6;5;4;5;3;5;3;2;5;8;9;9;3;4;5;3;5;4;3;5;5;1;6;3;3;4;5;5;7;6;6;5;5;5;4;6;7;5;2;6;5;4;4;5;3;3;5;2;4;6;5;5;7;5;5;5;5;6;6;3;4;2;2;6;3;2;4;4;8;3;5;5;2;5;3;4;8;4;4;4;4;4;4;8;6;4;6;5;5;6;7;5;6;6;6;3;4;3;3;6;6;2;3;5;2;4;7;3;5;5;3;3;5;4;4;5;7;7;7;3;3; GO:0030425;GO:0030424;GO:0097060;GO:0016020;GO:0098589;GO:0044297;GO:0036477;GO:0042995;GO:0043232;GO:0030054;GO:0098858;GO:0044424;GO:0044425;GO:0098590;GO:0030175;GO:0043228;GO:0005856;GO:0043025;GO:0031252;GO:0060076;GO:0005737;GO:0044456;GO:0043005;GO:0044459;GO:0045211;GO:0014069;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0015629;GO:0099572;GO:0071944;GO:0045202;GO:0098805;GO:0043226;GO:0097458;GO:0030027;GO:0005886;GO:0005575;GO:0098794; dendrite;axon;synaptic membrane;membrane;membrane region;cell body;somatodendritic compartment;cell projection;intracellular non-membrane-bounded organelle;cell junction;actin-based cell projection;intracellular part;membrane part;plasma membrane region;filopodium;non-membrane-bounded organelle;cytoskeleton;neuronal cell body;cell leading edge;excitatory synapse;cytoplasm;synapse part;neuron projection;plasma membrane part;postsynaptic membrane;postsynaptic density;cell part;intracellular organelle;cell;intracellular;actin cytoskeleton;postsynaptic specialization;cell periphery;synapse;whole membrane;organelle;neuron part;lamellipodium;plasma membrane;cellular_component;postsynapse; 5;5;3;2;3;3;4;3;4;2;4;3;2;4;5;3;5;4;3;3;4;2;4;3;4;4;2;3;2;3;6;3;3;2;3;2;3;4;3;1;3; GO:0019901;GO:0019900;GO:0003674;GO:0005488;GO:0019904;GO:0019899;GO:0005515; protein kinase binding;kinase binding;molecular_function;binding;protein domain specific binding;enzyme binding;protein binding; 6;5;1;2;4;4;3; K19930 IPR026727;IPR022782; SRC kinase signalling inhibitor 1;Actin interacting protein 3, C-terminal; nucleus P09471 Guanine nucleotide-binding protein G(o) subunit alpha OS=Homo sapiens OX=9606 GN=GNAO1 PE=1 SV=4 - [GNAO_HUMAN] 1.278 1.167 0.704 1.045 0.882 1.286 1.095115681 0.628755384 1.184807256 0.452671795 0.603256213 0.080567561 1.458049887 0.508914242 GO:0051049;GO:0048468;GO:0003012;GO:0003013;GO:0007165;GO:0043279;GO:0071840;GO:0051716;GO:0010035;GO:0007212;GO:0048869;GO:0048513;GO:0010959;GO:0044093;GO:0048519;GO:0006936;GO:0072511;GO:0010033;GO:0003008;GO:0044700;GO:0044707;GO:0010243;GO:0060322;GO:0003015;GO:0042493;GO:0006810;GO:0000302;GO:0014070;GO:0031175;GO:0050789;GO:0043547;GO:0051345;GO:0014072;GO:0016043;GO:0009719;GO:0007188;GO:0065007;GO:0043085;GO:0065009;GO:0007186;GO:0007187;GO:0007626;GO:0008016;GO:0034097;GO:0008015;GO:0006812;GO:0006811;GO:0050790;GO:0006816;GO:0050794;GO:0006950;GO:0008150;GO:0051239;GO:0051234;GO:0051336;GO:0044767;GO:0007420;GO:0042542;GO:0050896;GO:1903522;GO:0030154;GO:0060047;GO:0023052;GO:0042221;GO:0043087;GO:0044699;GO:0007417;GO:0044057;GO:0032502;GO:0032501;GO:0009987;GO:0007610;GO:0030001;GO:0043278;GO:0032879;GO:0006979;GO:0007568;GO:0048731;GO:1901698;GO:0051924;GO:0030030;GO:0007275;GO:0051051;GO:0070838;GO:0043269;GO:0048666;GO:0030182;GO:0044765;GO:0044763;GO:0007154;GO:0022008;GO:0051179;GO:1902578;GO:1901700;GO:0048699;GO:0007399;GO:0043271;GO:0051926;GO:0048856;GO:0030900; regulation of transport;cell development;muscle system process;circulatory system process;signal transduction;response to alkaloid;cellular component organization or biogenesis;cellular response to stimulus;response to inorganic substance;dopamine receptor signaling pathway;cellular developmental process;animal organ development;regulation of metal ion transport;positive regulation of molecular function;negative regulation of biological process;muscle contraction;divalent inorganic cation transport;response to organic substance;system process;single organism signaling;single-multicellular organism process;response to organonitrogen compound;head development;heart process;response to drug;transport;response to reactive oxygen species;response to organic cyclic compound;neuron projection development;regulation of biological process;positive regulation of GTPase activity;positive regulation of hydrolase activity;response to isoquinoline alkaloid;cellular component organization;response to endogenous stimulus;adenylate cyclase-modulating G-protein coupled receptor signaling pathway;biological regulation;positive regulation of catalytic activity;regulation of molecular function;G-protein coupled receptor signaling pathway;G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;locomotory behavior;regulation of heart contraction;response to cytokine;blood circulation;cation transport;ion transport;regulation of catalytic activity;calcium ion transport;regulation of cellular process;response to stress;biological_process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;single-organism developmental process;brain development;response to hydrogen peroxide;response to stimulus;regulation of blood circulation;cell differentiation;heart contraction;signaling;response to chemical;regulation of GTPase activity;single-organism process;central nervous system development;regulation of system process;developmental process;multicellular organismal process;cellular process;behavior;metal ion transport;response to morphine;regulation of localization;response to oxidative stress;aging;system development;response to nitrogen compound;regulation of calcium ion transport;cell projection organization;multicellular organism development;negative regulation of transport;divalent metal ion transport;regulation of ion transport;neuron development;neuron differentiation;single-organism transport;single-organism cellular process;cell communication;neurogenesis;localization;single-organism localization;response to oxygen-containing compound;generation of neurons;nervous system development;negative regulation of ion transport;negative regulation of calcium ion transport;anatomical structure development;forebrain development; 4;4;4;4;4;5;2;3;4;6;4;4;6;4;2;5;7;4;3;3;3;4;4;5;4;4;5;5;5;2;7;6;6;3;3;7;2;5;3;5;6;3;6;5;5;6;5;4;9;3;3;1;3;3;5;3;4;5;2;5;5;6;2;3;6;2;5;4;2;2;2;2;7;7;3;4;4;4;4;7;4;4;3;8;5;5;6;4;3;4;6;2;3;4;7;5;4;5;3;4; GO:0030425;GO:0016020;GO:1902494;GO:0044297;GO:0036477;GO:0042995;GO:0043234;GO:0044424;GO:0044425;GO:0009898;GO:0005623;GO:0019897;GO:0019898;GO:0043005;GO:0043209;GO:0044459;GO:0044464;GO:0005622;GO:0031234;GO:0071944;GO:0098552;GO:0098797;GO:0097458;GO:0005834;GO:0098562;GO:0005886;GO:0032991;GO:0005575;GO:0098796; dendrite;membrane;catalytic complex;cell body;somatodendritic compartment;cell projection;protein complex;intracellular part;membrane part;cytoplasmic side of plasma membrane;cell;extrinsic component of plasma membrane;extrinsic component of membrane;neuron projection;myelin sheath;plasma membrane part;cell part;intracellular;extrinsic component of cytoplasmic side of plasma membrane;cell periphery;side of membrane;plasma membrane protein complex;neuron part;heterotrimeric G-protein complex;cytoplasmic side of membrane;plasma membrane;macromolecular complex;cellular_component;membrane protein complex; 5;2;4;3;4;3;3;3;2;4;2;4;3;4;3;3;2;3;4;3;3;4;3;4;4;3;2;1;3; GO:1901363;GO:0000166;GO:0046872;GO:0044877;GO:0071855;GO:0016818;GO:0097367;GO:0016817;GO:0016787;GO:0003674;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0003824;GO:0097159;GO:0019001;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0001664;GO:0043168;GO:0043169;GO:0043167;GO:0032561;GO:0032403;GO:0031821;GO:0051428;GO:0051429;GO:0051427;GO:0031628;GO:0005515;GO:0005102;GO:0005488;GO:0031852;GO:0004871;GO:0001883;GO:0001882;GO:0016462;GO:0051430;GO:0031683;GO:0003924;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;metal ion binding;macromolecular complex binding;neuropeptide receptor binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;hydrolase activity;molecular_function;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;catalytic activity;organic cyclic compound binding;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;G-protein coupled receptor binding;anion binding;cation binding;ion binding;guanyl ribonucleotide binding;protein complex binding;G-protein coupled serotonin receptor binding;peptide hormone receptor binding;corticotropin-releasing hormone receptor binding;hormone receptor binding;opioid receptor binding;protein binding;receptor binding;binding;mu-type opioid receptor binding;signal transducer activity;purine nucleoside binding;nucleoside binding;pyrophosphatase activity;corticotropin-releasing hormone receptor 1 binding;G-protein beta/gamma-subunit complex binding;GTPase activity;nucleoside-triphosphatase activity;small molecule binding; 3;4;5;3;6;5;3;4;3;1;4;5;5;6;2;3;6;5;6;4;5;5;4;4;3;6;4;6;6;7;5;6;3;4;2;7;2;5;4;6;8;5;8;7;3; K04534 map04015;map04713;map04723;map04724;map04725;map04726;map04727;map04728;map04730;map04915;map04916;map04921;map05032;map05034;map05142;map05145; Rap1 signaling pathway;Circadian entrainment;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;Serotonergic synapse;GABAergic synapse;Dopaminergic synapse;Long-term depression;Estrogen signaling pathway;Melanogenesis;Oxytocin signaling pathway;Morphine addiction;Alcoholism;Chagas disease (American trypanosomiasis);Toxoplasmosis; IPR011025;IPR001019;IPR001408;IPR027417; G protein alpha subunit, helical insertion;Guanine nucleotide binding protein (G-protein), alpha subunit;G-protein alpha subunit, group I;P-loop containing nucleoside triphosphate hydrolase; cytosol, mitochondria Hs10567816 740.0 DT [D] Cell cycle control, cell division, chromosome partitioning;[T] Signal transduction mechanisms; O60524 Nuclear export mediator factor NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4 - [NEMF_HUMAN] 1.05 1.067 1.025 1.216 0.926 0.803 0.984067479 nan 1.313174946 nan 0.960637301 nan 0.867170626 nan GO:0051169;GO:0051168;GO:0046907;GO:0006810;GO:0006913;GO:0008150;GO:0051649;GO:0051179;GO:0051234;GO:0051641; nuclear transport;nuclear export;intracellular transport;transport;nucleocytoplasmic transport;biological_process;establishment of localization in cell;localization;establishment of localization;cellular localization; 6;8;5;4;7;1;4;2;3;3; GO:0043231;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0044424;GO:0043227;GO:0043226; intracellular membrane-bounded organelle;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle;intracellular part;membrane-bounded organelle;organelle; 4;5;2;2;3;1;3;3;3;2; IPR008532;IPR021846; Domain of unknown function DUF814;Domain of unknown function DUF3441; cytosol Hs22048155 846.0 R [R] General function prediction only; Q9NXR7 BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2 - [BABA2_HUMAN] 1.438 0.539 1.539 0.88 0.705 0.661 2.667903525 nan 1.24822695 nan 2.85528757 nan 0.937588652 nan GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0007165;GO:0071840;GO:0051716;GO:0006303;GO:0006302;GO:0070647;GO:0070646;GO:0070536;GO:0051054;GO:0006282;GO:0006281;GO:0060255;GO:2001020;GO:2001022;GO:0046483;GO:0044700;GO:0019538;GO:0033554;GO:0009893;GO:0006807;GO:0007067;GO:0050789;GO:0044267;GO:0031572;GO:0031570;GO:0016043;GO:0065007;GO:0007049;GO:0016579;GO:0044710;GO:0050794;GO:0012501;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0010212;GO:0010604;GO:0050896;GO:0080135;GO:0043412;GO:0016568;GO:0045739;GO:0009314;GO:0034641;GO:0023052;GO:0051276;GO:0044699;GO:0006139;GO:0000726;GO:0000725;GO:0000724;GO:0000280;GO:0006508;GO:0006996;GO:0009628;GO:0009987;GO:0006725;GO:0006974;GO:0048518;GO:1903047;GO:0000077;GO:0043170;GO:0080134;GO:0043933;GO:0031325;GO:0031323;GO:0090304;GO:0022402;GO:0008219;GO:0051301;GO:0051052;GO:0006325;GO:1901360;GO:0071704;GO:0045935;GO:0000278;GO:0019219;GO:0006915;GO:0006464;GO:0044763;GO:0051171;GO:0051173;GO:0007154;GO:0006310;GO:0044238;GO:0044260;GO:0000075;GO:0044237;GO:1902589;GO:0048285;GO:0006259;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;double-strand break repair via nonhomologous end joining;double-strand break repair;protein modification by small protein conjugation or removal;protein modification by small protein removal;protein K63-linked deubiquitination;positive regulation of DNA metabolic process;regulation of DNA repair;DNA repair;regulation of macromolecule metabolic process;regulation of response to DNA damage stimulus;positive regulation of response to DNA damage stimulus;heterocycle metabolic process;single organism signaling;protein metabolic process;cellular response to stress;positive regulation of metabolic process;nitrogen compound metabolic process;mitotic nuclear division;regulation of biological process;cellular protein metabolic process;G2 DNA damage checkpoint;DNA integrity checkpoint;cellular component organization;biological regulation;cell cycle;protein deubiquitination;single-organism metabolic process;regulation of cellular process;programmed cell death;response to stress;protein modification process;biological_process;metabolic process;response to ionizing radiation;positive regulation of macromolecule metabolic process;response to stimulus;regulation of cellular response to stress;macromolecule modification;chromatin modification;positive regulation of DNA repair;response to radiation;cellular nitrogen compound metabolic process;signaling;chromosome organization;single-organism process;nucleobase-containing compound metabolic process;non-recombinational repair;recombinational repair;double-strand break repair via homologous recombination;nuclear division;proteolysis;organelle organization;response to abiotic stimulus;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;positive regulation of biological process;mitotic cell cycle process;DNA damage checkpoint;macromolecule metabolic process;regulation of response to stress;macromolecular complex subunit organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;cell death;cell division;regulation of DNA metabolic process;chromatin organization;organic cyclic compound metabolic process;organic substance metabolic process;positive regulation of nucleobase-containing compound metabolic process;mitotic cell cycle;regulation of nucleobase-containing compound metabolic process;apoptotic process;cellular protein modification process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;DNA recombination;primary metabolic process;cellular macromolecule metabolic process;cell cycle checkpoint;cellular metabolic process;single-organism organelle organization;organelle fission;DNA metabolic process;positive regulation of cellular process; 4;3;3;3;4;2;3;6;5;7;6;8;5;5;4;4;5;4;4;3;4;4;3;3;5;2;5;7;6;3;2;4;7;3;3;5;3;5;1;2;5;4;2;4;5;6;5;4;4;2;5;2;4;5;5;6;6;5;4;3;2;4;5;2;5;6;4;4;4;4;4;5;4;4;4;5;5;4;3;5;5;5;6;6;3;4;4;4;6;3;4;5;3;4;5;5;3; GO:0031974;GO:0031981;GO:0070531;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0000151;GO:0000152;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0070552;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;BRCA1-A complex;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;ubiquitin ligase complex;nuclear ubiquitin ligase complex;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;BRISC complex;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;4;5;3;4;3;4;5;4;3;2;3;3;3;5;3;4;5;2;2;4;2;2;1;4; GO:0031593;GO:0043130;GO:0005126;GO:0032182;GO:0003674;GO:0005488;GO:0032813;GO:0042277;GO:0033218;GO:0005048;GO:0005515;GO:0005102;GO:0000268;GO:0005164; polyubiquitin binding;ubiquitin binding;cytokine receptor binding;ubiquitin-like protein binding;molecular_function;binding;tumor necrosis factor receptor superfamily binding;peptide binding;amide binding;signal sequence binding;protein binding;receptor binding;peroxisome targeting sequence binding;tumor necrosis factor receptor binding; 6;5;5;4;1;2;6;4;3;5;3;4;6;7; K12173 IPR010358;IPR016135; BRCA1-A complex subunit BRE;Ubiquitin-conjugating enzyme/RWD-like; mitochondria HsM4757872 798.0 T [T] Signal transduction mechanisms; Q5T6L9 Endoplasmic reticulum membrane-associated RNA degradation protein OS=Homo sapiens OX=9606 GN=ERMARD PE=1 SV=1 - [EMARD_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0044699;GO:0007275;GO:0032502;GO:0032501;GO:0044767;GO:0008150;GO:0044707;GO:0048856; single-organism process;multicellular organism development;developmental process;multicellular organismal process;single-organism developmental process;biological_process;single-multicellular organism process;anatomical structure development; 2;4;2;2;3;1;3;3; GO:0005783;GO:0005789;GO:0042175;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0031090;GO:0016021;GO:0016020;GO:0044432;GO:0031224;GO:0098588;GO:0012505;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044425;GO:0044422; endoplasmic reticulum;endoplasmic reticulum membrane;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;organelle membrane;integral component of membrane;membrane;endoplasmic reticulum part;intrinsic component of membrane;bounding membrane of organelle;endomembrane system;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;membrane part;organelle part; 4;3;3;3;3;2;4;3;3;4;2;4;3;4;3;4;2;2;3;1;4;3;2;2; IPR025209; Domain of unknown function DUF4209; plasma membrane Q9HBM0 Vezatin OS=Homo sapiens OX=9606 GN=VEZT PE=1 SV=3 - [VEZA_HUMAN] 0.984 0.824 1.391 0.952 0.948 0.884 1.194174757 0.290064793 1.004219409 0.951332293 1.688106796 0.116591091 0.932489451 0.508327253 GO:0016337;GO:0044699;GO:0022610;GO:0098602;GO:0098609;GO:0008150;GO:0007155; single organismal cell-cell adhesion;single-organism process;biological adhesion;single organism cell adhesion;cell-cell adhesion;biological_process;cell adhesion; 4;2;2;3;4;1;3; GO:0031974;GO:0043229;GO:0071944;GO:0001669;GO:0005912;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0005575;GO:0031982;GO:0031981;GO:0016023;GO:0031410;GO:0016021;GO:0016020;GO:0097223;GO:0031988;GO:0005654;GO:0099503;GO:0030141;GO:0070161;GO:0012505;GO:0005886;GO:0043231;GO:0043233;GO:0030054;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044425;GO:0005634;GO:0044422;GO:0097708; membrane-enclosed lumen;intracellular organelle;cell periphery;acrosomal vesicle;adherens junction;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;cellular_component;vesicle;nuclear lumen;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;integral component of membrane;membrane;sperm part;membrane-bounded vesicle;nucleoplasm;secretory vesicle;secretory granule;anchoring junction;endomembrane system;plasma membrane;intracellular membrane-bounded organelle;organelle lumen;cell junction;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;membrane part;nucleus;organelle part;intracellular vesicle; 2;3;3;4;4;3;2;3;4;1;4;5;5;5;4;2;3;5;5;6;4;3;3;3;4;3;2;2;2;3;3;4;4;4;3;2;5;2;4; IPR026859;IPR026858; Myosin-binding domain;Vezatin; plasma membrane Q9UBM8 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C OS=Homo sapiens OX=9606 GN=MGAT4C PE=2 SV=2 - [MGT4C_HUMAN] 1.106 0.994 0.781 1.121 1.233 1.059 1.112676056 nan 0.909164639 nan 0.785714286 nan 0.858880779 nan GO:0044238;GO:0043413;GO:0009311;GO:0044249;GO:0034645;GO:0009100;GO:0009101;GO:0044699;GO:0044267;GO:0044710;GO:0006486;GO:0006487;GO:0018196;GO:0018193;GO:0071704;GO:0043687;GO:0018279;GO:1901576;GO:0009987;GO:0070085;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0005975;GO:0044260;GO:0006491;GO:0019538;GO:1901135;GO:0044763;GO:0009058;GO:0044237;GO:0043170;GO:1901137;GO:0009059; primary metabolic process;macromolecule glycosylation;oligosaccharide metabolic process;cellular biosynthetic process;cellular macromolecule biosynthetic process;glycoprotein metabolic process;glycoprotein biosynthetic process;single-organism process;cellular protein metabolic process;single-organism metabolic process;protein glycosylation;protein N-linked glycosylation;peptidyl-asparagine modification;peptidyl-amino acid modification;organic substance metabolic process;post-translational protein modification;protein N-linked glycosylation via asparagine;organic substance biosynthetic process;cellular process;glycosylation;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;carbohydrate metabolic process;cellular macromolecule metabolic process;N-glycan processing;protein metabolic process;carbohydrate derivative metabolic process;single-organism cellular process;biosynthetic process;cellular metabolic process;macromolecule metabolic process;carbohydrate derivative biosynthetic process;macromolecule biosynthetic process; 3;6;5;4;5;5;6;2;5;3;4;5;8;7;3;7;6;4;2;5;6;5;5;1;2;4;4;4;6;4;4;3;3;3;4;5;5; GO:0044464;GO:0043229;GO:0005623;GO:0000139;GO:0005737;GO:0031090;GO:0043227;GO:0016021;GO:0044431;GO:0043226;GO:0031224;GO:0005794;GO:0005622;GO:0098588;GO:0044446;GO:0012505;GO:0044425;GO:0016020;GO:0043231;GO:0005575;GO:0044444;GO:0044424;GO:0044422; cell part;intracellular organelle;cell;Golgi membrane;cytoplasm;organelle membrane;membrane-bounded organelle;integral component of membrane;Golgi apparatus part;organelle;intrinsic component of membrane;Golgi apparatus;intracellular;bounding membrane of organelle;intracellular organelle part;endomembrane system;membrane part;membrane;intracellular membrane-bounded organelle;cellular_component;cytoplasmic part;intracellular part;organelle part; 2;3;2;5;4;3;3;4;4;2;3;4;3;4;3;3;2;2;4;1;4;3;2; GO:0043169;GO:0003674;GO:0008375;GO:0016740;GO:0046872;GO:0003824;GO:0008194;GO:0008454;GO:0043167;GO:0016757;GO:0016758;GO:0005488; cation binding;molecular_function;acetylglucosaminyltransferase activity;transferase activity;metal ion binding;catalytic activity;UDP-glycosyltransferase activity;alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity;ion binding;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;binding; 4;1;6;3;5;2;5;7;3;4;5;2; K13748 map00510;map00513;map01100; N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways; IPR006759; Glycosyl transferase family 54; plasma membrane Hs7019407 997.0 O [O] Posttranslational modification, protein turnover, chaperones; O95258 Brain mitochondrial carrier protein 1 OS=Homo sapiens OX=9606 GN=SLC25A14 PE=2 SV=1 - [UCP5_HUMAN] 0.903 0.895 1.398 0.856 0.967 1.015 1.008938547 0.398524209 0.885211996 0.006551851 1.562011173 4.57E-10 1.049638056 0.776518308 GO:0044281;GO:0044710;GO:0043043;GO:0022900;GO:0022904;GO:0006839;GO:0055114;GO:1901564;GO:1901566;GO:0019538;GO:0009060;GO:0044267;GO:0015992;GO:0044260;GO:0044699;GO:0006818;GO:0006812;GO:0006811;GO:0006810;GO:0008150;GO:0008152;GO:0051234;GO:0044271;GO:0015980;GO:0046907;GO:0044765;GO:0045333;GO:0006518;GO:0044249;GO:0034641;GO:0034645;GO:0015672;GO:0009987;GO:0043604;GO:0043603;GO:0043170;GO:0006807;GO:0006091;GO:0071704;GO:0010467;GO:1901576;GO:0009058;GO:0009059;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0044237;GO:1902582;GO:0006412; small molecule metabolic process;single-organism metabolic process;peptide biosynthetic process;electron transport chain;respiratory electron transport chain;mitochondrial transport;oxidation-reduction process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;aerobic respiration;cellular protein metabolic process;proton transport;cellular macromolecule metabolic process;single-organism process;hydrogen transport;cation transport;ion transport;transport;biological_process;metabolic process;establishment of localization;cellular nitrogen compound biosynthetic process;energy derivation by oxidation of organic compounds;intracellular transport;single-organism transport;cellular respiration;peptide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;monovalent inorganic cation transport;cellular process;amide biosynthetic process;cellular amide metabolic process;macromolecule metabolic process;nitrogen compound metabolic process;generation of precursor metabolites and energy;organic substance metabolic process;gene expression;organic substance biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;primary metabolic process;cellular metabolic process;single-organism intracellular transport;translation; 4;3;6;4;5;6;4;4;5;4;6;5;6;4;2;5;6;5;4;1;2;3;5;4;5;4;5;5;4;4;5;7;2;6;5;4;3;4;3;5;4;3;5;3;4;2;3;3;3;3;5;6; GO:0031975;GO:0016021;GO:0016020;GO:0031967;GO:0031966;GO:0043231;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0044464;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044446;GO:0044444;GO:0005886;GO:0031226;GO:0031224;GO:0005737;GO:0031090;GO:0005739;GO:0044459;GO:0019866;GO:0005623;GO:0005743;GO:0005740;GO:0071944;GO:0005887;GO:0005575; envelope;integral component of membrane;membrane;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;mitochondrial part;intracellular part;membrane part;organelle part;cell part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasmic part;plasma membrane;intrinsic component of plasma membrane;intrinsic component of membrane;cytoplasm;organelle membrane;mitochondrion;plasma membrane part;organelle inner membrane;cell;mitochondrial inner membrane;mitochondrial envelope;cell periphery;integral component of plasma membrane;cellular_component; 3;4;2;4;4;4;4;3;2;2;2;3;3;3;2;3;4;3;4;3;4;3;5;3;4;2;5;5;3;4;1; GO:0003674;GO:0005198;GO:0003735; molecular_function;structural molecule activity;structural constituent of ribosome; 1;2;3; K15106 IPR032933;IPR002030;IPR018108;IPR023395; Brain mitochondrial carrier protein 1;Mitochondrial carrier UCP-like;Mitochondrial substrate/solute carrier;Mitochondrial carrier domain; plasma membrane Hs4507009 665.0 C [C] Energy production and conversion; P25874 Mitochondrial brown fat uncoupling protein 1 OS=Homo sapiens OX=9606 GN=UCP1 PE=1 SV=3 - [UCP1_HUMAN] 1.086 0.937 1.176 0.885 1.088 0.833 1.159018143 nan 0.813419118 nan 1.25506937 nan 0.765625 nan GO:0080090;GO:0019222;GO:0044281;GO:1901362;GO:1901360;GO:0044710;GO:0048869;GO:0043043;GO:0022900;GO:0022904;GO:0060255;GO:2001141;GO:0006839;GO:0055114;GO:0046483;GO:1901564;GO:1901566;GO:0019538;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0015992;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0006818;GO:0006812;GO:0006811;GO:0006810;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0019438;GO:0034654;GO:0051234;GO:0016070;GO:0044271;GO:0015980;GO:0046907;GO:0009058;GO:0006355;GO:0006357;GO:0006351;GO:0045333;GO:0006518;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0015672;GO:0032502;GO:0009987;GO:0006725;GO:0050873;GO:1903506;GO:0043604;GO:0043603;GO:0051252;GO:0043170;GO:0031326;GO:0031323;GO:0090304;GO:0045444;GO:0006091;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0044267;GO:0019219;GO:0044767;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0044237;GO:1902582;GO:0006412; regulation of primary metabolic process;regulation of metabolic process;small molecule metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;cellular developmental process;peptide biosynthetic process;electron transport chain;respiratory electron transport chain;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;mitochondrial transport;oxidation-reduction process;heterocycle metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;proton transport;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;hydrogen transport;cation transport;ion transport;transport;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;aromatic compound biosynthetic process;nucleobase-containing compound biosynthetic process;establishment of localization;RNA metabolic process;cellular nitrogen compound biosynthetic process;energy derivation by oxidation of organic compounds;intracellular transport;biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;cellular respiration;peptide metabolic process;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;monovalent inorganic cation transport;developmental process;cellular process;cellular aromatic compound metabolic process;brown fat cell differentiation;regulation of nucleic acid-templated transcription;amide biosynthetic process;cellular amide metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;fat cell differentiation;generation of precursor metabolites and energy;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;establishment of localization in cell;localization;single-organism localization;cellular localization;primary metabolic process;cellular metabolic process;single-organism intracellular transport;translation; 4;3;4;5;4;3;4;6;4;5;4;6;6;4;4;4;5;4;3;2;7;4;6;4;2;7;5;5;6;5;4;4;3;1;2;5;5;3;5;5;4;5;3;6;7;6;5;5;6;5;4;4;5;2;4;7;2;2;4;7;7;6;5;5;4;5;4;5;6;4;6;3;5;5;5;5;5;3;4;5;3;4;4;2;3;3;3;3;5;6; GO:0031975;GO:0016021;GO:0016020;GO:0031967;GO:0031966;GO:0043231;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0019866;GO:0043229;GO:0005622;GO:0043227;GO:0031224;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005739;GO:0044464;GO:0005623;GO:0005743;GO:0005740;GO:0043226;GO:0005575; envelope;integral component of membrane;membrane;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;mitochondrial part;intracellular part;membrane part;organelle part;organelle inner membrane;intracellular organelle;intracellular;membrane-bounded organelle;intrinsic component of membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;mitochondrion;cell part;cell;mitochondrial inner membrane;mitochondrial envelope;organelle;cellular_component; 3;4;2;4;4;4;4;3;2;2;4;3;3;3;3;3;4;4;3;5;2;2;5;5;2;1; GO:0005198;GO:0003674;GO:0017077;GO:0005215;GO:0003735;GO:0022857; structural molecule activity;molecular_function;oxidative phosphorylation uncoupler activity;transporter activity;structural constituent of ribosome;transmembrane transporter activity; 2;1;4;2;3;3; K08769 map03320;map05016; PPAR signaling pathway;Huntington's disease; IPR002030;IPR018108;IPR023395; Mitochondrial carrier UCP-like;Mitochondrial substrate/solute carrier;Mitochondrial carrier domain; cytosol Hs11225256 632.0 C [C] Energy production and conversion; Q9NVE5 Ubiquitin carboxyl-terminal hydrolase 40 OS=Homo sapiens OX=9606 GN=USP40 PE=1 SV=3 - [UBP40_HUMAN] 1.094 1.317 0.764 1.041 1.092 0.762 0.830675778 0.065578465 0.953296703 0.668191476 0.580106302 0.0212063 0.697802198 0.241891724 GO:0044248;GO:0044237;GO:0043632;GO:0043170;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0070647;GO:0070646;GO:0071704;GO:0006508;GO:0016579;GO:0051603;GO:0009987;GO:0019941;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0030163;GO:0008152;GO:0044257;GO:0009056;GO:0009057;GO:0044238;GO:0019538;GO:0006511; cellular catabolic process;cellular metabolic process;modification-dependent macromolecule catabolic process;macromolecule metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;protein modification by small protein conjugation or removal;protein modification by small protein removal;organic substance metabolic process;proteolysis;protein deubiquitination;proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;protein catabolic process;metabolic process;cellular protein catabolic process;catabolic process;macromolecule catabolic process;primary metabolic process;protein metabolic process;ubiquitin-dependent protein catabolic process; 4;3;6;4;5;4;5;4;7;6;3;5;7;6;2;7;6;5;5;1;5;2;6;3;5;3;4;8; GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;4;5;4;2;2;3;1;3; GO:0101005;GO:0003674;GO:0019783;GO:0008234;GO:0070011;GO:0016787;GO:0003824;GO:0036459;GO:0008233; ubiquitinyl hydrolase activity;molecular_function;ubiquitin-like protein-specific protease activity;cysteine-type peptidase activity;peptidase activity, acting on L-amino acid peptides;hydrolase activity;catalytic activity;thiol-dependent ubiquitinyl hydrolase activity;peptidase activity; 4;1;7;6;5;3;2;5;4; K11869 IPR028889;IPR001394;IPR018200; Ubiquitin specific protease domain;Peptidase C19, ubiquitin carboxyl-terminal hydrolase;Ubiquitin specific protease, conserved site; nucleus Q9Y5Y7 Lymphatic vessel endothelial hyaluronic acid receptor 1 OS=Homo sapiens OX=9606 GN=LYVE1 PE=1 SV=2 - [LYVE1_HUMAN] 0.96 1.026 1.019 0.921 1.1 1.204 0.935672515 0.021243061 0.837272727 0.035907826 0.993177388 0.371424005 1.094545455 0.201395146 GO:0030203;GO:0050896;GO:0031589;GO:1903510;GO:0007160;GO:0006807;GO:0009653;GO:0044699;GO:0044712;GO:1901575;GO:0006928;GO:0009611;GO:0009057;GO:0071704;GO:0006027;GO:0022610;GO:0032502;GO:0030212;GO:0009987;GO:0030214;GO:0006810;GO:0044710;GO:0044281;GO:0006950;GO:0008150;GO:0008152;GO:0007155;GO:0005975;GO:0051234;GO:0009056;GO:0051179;GO:0044238;GO:1901564;GO:1901565;GO:1901136;GO:1901135;GO:0048856;GO:0043170;GO:0006022;GO:0044763;GO:0006026; glycosaminoglycan metabolic process;response to stimulus;cell-substrate adhesion;mucopolysaccharide metabolic process;cell-matrix adhesion;nitrogen compound metabolic process;anatomical structure morphogenesis;single-organism process;single-organism catabolic process;organic substance catabolic process;movement of cell or subcellular component;response to wounding;macromolecule catabolic process;organic substance metabolic process;glycosaminoglycan catabolic process;biological adhesion;developmental process;hyaluronan metabolic process;cellular process;hyaluronan catabolic process;transport;single-organism metabolic process;small molecule metabolic process;response to stress;biological_process;metabolic process;cell adhesion;carbohydrate metabolic process;establishment of localization;catabolic process;localization;primary metabolic process;organonitrogen compound metabolic process;organonitrogen compound catabolic process;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;anatomical structure development;macromolecule metabolic process;aminoglycan metabolic process;single-organism cellular process;aminoglycan catabolic process; 6;2;4;7;5;3;3;2;4;4;4;4;5;3;7;2;2;8;2;5;4;3;4;3;1;2;3;4;3;3;2;3;4;5;5;4;3;4;5;3;6; GO:0005887;GO:0043227;GO:0043226;GO:1903561;GO:0070062;GO:0031226;GO:0016021;GO:0016020;GO:0031224;GO:0044425;GO:0044459;GO:0071944;GO:0043230;GO:0005886;GO:0031982;GO:0044464;GO:0005623;GO:0005575;GO:0005576;GO:0044421; integral component of plasma membrane;membrane-bounded organelle;organelle;extracellular vesicle;extracellular exosome;intrinsic component of plasma membrane;integral component of membrane;membrane;intrinsic component of membrane;membrane part;plasma membrane part;cell periphery;extracellular organelle;plasma membrane;vesicle;cell part;cell;cellular_component;extracellular region;extracellular region part; 4;3;2;3;4;4;4;2;3;2;3;3;3;3;4;2;2;1;2;2; GO:0060089;GO:0003674;GO:0005488;GO:0004871;GO:0038023;GO:0005539;GO:0005540;GO:0097367;GO:0004888;GO:0099600;GO:0004872; molecular transducer activity;molecular_function;binding;signal transducer activity;signaling receptor activity;glycosaminoglycan binding;hyaluronic acid binding;carbohydrate derivative binding;transmembrane signaling receptor activity;transmembrane receptor activity;receptor activity; 2;1;2;2;3;4;5;3;4;4;3; K19012 IPR000538;IPR016186;IPR016187; Link domain;C-type lectin-like/link domain;C-type lectin fold; mitochondria Q496Y0 LON peptidase N-terminal domain and RING finger protein 3 OS=Homo sapiens OX=9606 GN=LONRF3 PE=1 SV=1 - [LONF3_HUMAN] 1.202 1.46 0.51 1.161 1.116 0.572 0.823287671 nan 1.040322581 nan 0.349315068 nan 0.512544803 nan GO:0004176;GO:0016787;GO:0016818;GO:0043167;GO:0046914;GO:0042623;GO:0046872;GO:0043169;GO:0016817;GO:0017111;GO:0003824;GO:0070011;GO:0003674;GO:0005488;GO:0016887;GO:0008233;GO:0016462;GO:0008270; ATP-dependent peptidase activity;hydrolase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;ion binding;transition metal ion binding;ATPase activity, coupled;metal ion binding;cation binding;hydrolase activity, acting on acid anhydrides;nucleoside-triphosphatase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides;molecular_function;binding;ATPase activity;peptidase activity;pyrophosphatase activity;zinc ion binding; 6;3;5;3;6;9;5;4;4;7;2;5;1;2;8;4;6;7; IPR019734;IPR001841;IPR015947;IPR013083;IPR003111;IPR011990;IPR013026;IPR017907; Tetratricopeptide repeat;Zinc finger, RING-type;PUA-like domain;Zinc finger, RING/FYVE/PHD-type;Lon, substrate-binding domain;Tetratricopeptide-like helical domain;Tetratricopeptide repeat-containing domain;Zinc finger, RING-type, conserved site; nucleus Hs13376134_2 795.0 O [O] Posttranslational modification, protein turnover, chaperones; Q00872 Myosin-binding protein C, slow-type OS=Homo sapiens OX=9606 GN=MYBPC1 PE=1 SV=2 - [MYPC1_HUMAN] 0.909 1.038 0.981 1.042 0.998 1.729 0.875722543 0.489557314 1.044088176 0.670494646 0.945086705 0.743305453 1.73246493 0.219811275 GO:0033157;GO:0008104;GO:0032388;GO:0051049;GO:0032386;GO:0003012;GO:0071840;GO:0070727;GO:0048518;GO:1903749;GO:0006936;GO:0051050;GO:0006605;GO:0030049;GO:0030048;GO:1903955;GO:0072655;GO:0006839;GO:0003008;GO:0070585;GO:0010638;GO:1903651;GO:0006928;GO:0051222;GO:0051223;GO:0006886;GO:0016043;GO:0065007;GO:0007005;GO:0051130;GO:0070201;GO:1903649;GO:0006626;GO:0006810;GO:0050794;GO:0008150;GO:0051234;GO:0046907;GO:0033043;GO:0051128;GO:1903827;GO:1903533;GO:1904951;GO:0044699;GO:0032880;GO:0033275;GO:0022610;GO:0032501;GO:0072594;GO:0009987;GO:1903747;GO:1903829;GO:0032879;GO:0016482;GO:0033036;GO:0033365;GO:0060341;GO:0010821;GO:0010822;GO:0050789;GO:0071702;GO:0030029;GO:0034613;GO:0090316;GO:0044765;GO:0044763;GO:0051649;GO:0007155;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0045184;GO:1903214;GO:0015031;GO:1902582;GO:0070252;GO:1902580;GO:0048522; regulation of intracellular protein transport;protein localization;positive regulation of intracellular transport;regulation of transport;regulation of intracellular transport;muscle system process;cellular component organization or biogenesis;cellular macromolecule localization;positive regulation of biological process;positive regulation of establishment of protein localization to mitochondrion;muscle contraction;positive regulation of transport;protein targeting;muscle filament sliding;actin filament-based movement;positive regulation of protein targeting to mitochondrion;establishment of protein localization to mitochondrion;mitochondrial transport;system process;protein localization to mitochondrion;positive regulation of organelle organization;positive regulation of cytoplasmic transport;movement of cell or subcellular component;positive regulation of protein transport;regulation of protein transport;intracellular protein transport;cellular component organization;biological regulation;mitochondrion organization;positive regulation of cellular component organization;regulation of establishment of protein localization;regulation of cytoplasmic transport;protein targeting to mitochondrion;transport;regulation of cellular process;biological_process;establishment of localization;intracellular transport;regulation of organelle organization;regulation of cellular component organization;regulation of cellular protein localization;regulation of protein targeting;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;actin-myosin filament sliding;biological adhesion;multicellular organismal process;establishment of protein localization to organelle;cellular process;regulation of establishment of protein localization to mitochondrion;positive regulation of cellular protein localization;regulation of localization;cytosolic transport;macromolecule localization;protein localization to organelle;regulation of cellular localization;regulation of mitochondrion organization;positive regulation of mitochondrion organization;regulation of biological process;organic substance transport;actin filament-based process;cellular protein localization;positive regulation of intracellular protein transport;single-organism transport;single-organism cellular process;establishment of localization in cell;cell adhesion;localization;single-organism localization;cellular localization;organelle organization;establishment of protein localization;regulation of protein targeting to mitochondrion;protein transport;single-organism intracellular transport;actin-mediated cell contraction;single-organism cellular localization;positive regulation of cellular process; 6;4;4;4;5;4;2;4;2;4;5;3;6;6;5;5;6;6;3;7;5;5;4;4;5;6;3;2;5;4;5;6;5;4;3;1;3;5;5;4;5;7;3;2;4;7;2;2;5;2;6;3;3;6;3;6;4;6;6;2;5;4;5;4;4;3;4;3;2;3;3;4;4;6;5;5;6;4;3; GO:0016459;GO:0043234;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0044444;GO:0030016;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0032982;GO:0043292;GO:0032991;GO:0005575; myosin complex;protein complex;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;cytoplasmic part;myofibril;cytoplasm;cell part;cell;intracellular;actin cytoskeleton;myosin filament;contractile fiber;macromolecular complex;cellular_component; 4;3;4;5;3;2;3;3;2;5;4;3;4;6;4;2;2;3;6;5;5;2;1; GO:0005198;GO:0003674;GO:0005488;GO:0008307;GO:0008092;GO:0005515;GO:0031432; structural molecule activity;molecular_function;binding;structural constituent of muscle;cytoskeletal protein binding;protein binding;titin binding; 2;1;2;3;4;3;5; K12557 IPR003599;IPR003598;IPR013783;IPR013098;IPR007110;IPR003961; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;Immunoglobulin I-set;Immunoglobulin-like domain;Fibronectin type III; cytosol 118576441 72.4 X [X] Mobilome: prophages, transposons; COG4733 Phage-related protein, tail component P53675 Clathrin heavy chain 2 OS=Homo sapiens OX=9606 GN=CLTCL1 PE=1 SV=2 - [CLH2_HUMAN] 0.976 0.901 1.014 0.974 1.194 1.428 1.083240844 nan 0.815745394 nan 1.125416204 nan 1.1959799 nan GO:0008104;GO:0051049;GO:0007165;GO:0071840;GO:0051716;GO:0070727;GO:0048518;GO:0033036;GO:0051050;GO:0045184;GO:0016197;GO:0044700;GO:0016192;GO:0046324;GO:0046326;GO:0007067;GO:0000278;GO:0008645;GO:0006886;GO:0016043;GO:0008643;GO:0065007;GO:0007049;GO:0006810;GO:0050794;GO:0008150;GO:0042147;GO:0051234;GO:0006897;GO:0046907;GO:0050896;GO:0006898;GO:0023052;GO:0009653;GO:0044699;GO:0000280;GO:0032502;GO:0009987;GO:0032879;GO:0016482;GO:0007034;GO:0046323;GO:0048856;GO:1903047;GO:0010827;GO:0022402;GO:0010828;GO:0050789;GO:0015758;GO:0071702;GO:0034613;GO:0044765;GO:0044763;GO:0051649;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:1902589;GO:0048285;GO:0015749;GO:0015031;GO:1902582; protein localization;regulation of transport;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;cellular macromolecule localization;positive regulation of biological process;macromolecule localization;positive regulation of transport;establishment of protein localization;endosomal transport;single organism signaling;vesicle-mediated transport;regulation of glucose import;positive regulation of glucose import;mitotic nuclear division;mitotic cell cycle;hexose transport;intracellular protein transport;cellular component organization;carbohydrate transport;biological regulation;cell cycle;transport;regulation of cellular process;biological_process;retrograde transport, endosome to Golgi;establishment of localization;endocytosis;intracellular transport;response to stimulus;receptor-mediated endocytosis;signaling;anatomical structure morphogenesis;single-organism process;nuclear division;developmental process;cellular process;regulation of localization;cytosolic transport;vacuolar transport;glucose import;anatomical structure development;mitotic cell cycle process;regulation of glucose transport;cell cycle process;positive regulation of glucose transport;regulation of biological process;glucose transport;organic substance transport;cellular protein localization;single-organism transport;single-organism cellular process;establishment of localization in cell;cell communication;localization;single-organism localization;cellular localization;organelle organization;single-organism organelle organization;organelle fission;monosaccharide transport;protein transport;single-organism intracellular transport; 4;4;4;2;3;4;2;3;3;4;7;3;5;6;5;5;5;7;6;3;5;2;4;4;3;1;6;3;6;5;2;7;2;3;2;6;2;2;3;6;6;9;3;5;5;4;4;2;8;5;5;4;3;4;4;2;3;3;4;4;5;6;5;5; GO:0043234;GO:0030117;GO:0031984;GO:0031982;GO:0005773;GO:0016020;GO:0031988;GO:0005794;GO:0098588;GO:0098589;GO:0005798;GO:0043231;GO:0043230;GO:0043232;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0030118;GO:0044433;GO:0044431;GO:0044430;GO:0048475;GO:0030665;GO:0030140;GO:0012505;GO:0031090;GO:0000139;GO:0044446;GO:0016023;GO:0044444;GO:0097708;GO:0005770;GO:0012506;GO:0005905;GO:0012510;GO:0005737;GO:0030660;GO:0030662;GO:0031410;GO:0030658;GO:0030659;GO:0030125;GO:0030120;GO:0044464;GO:0005623;GO:0005622;GO:0097443;GO:0030130;GO:0030133;GO:0030135;GO:0030136;GO:0005819;GO:0070062;GO:0098805;GO:0015630;GO:0098791;GO:1903561;GO:0032991;GO:0005802;GO:0005575;GO:0098796;GO:0005576;GO:0005768; protein complex;membrane coat;organelle subcompartment;vesicle;vacuole;membrane;membrane-bounded vesicle;Golgi apparatus;bounding membrane of organelle;membrane region;Golgi-associated vesicle;intracellular membrane-bounded organelle;extracellular organelle;intracellular non-membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;clathrin coat;cytoplasmic vesicle part;Golgi apparatus part;cytoskeletal part;coated membrane;clathrin-coated vesicle membrane;trans-Golgi network transport vesicle;endomembrane system;organelle membrane;Golgi membrane;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;intracellular vesicle;late endosome;vesicle membrane;coated pit;trans-Golgi network transport vesicle membrane;cytoplasm;Golgi-associated vesicle membrane;coated vesicle membrane;cytoplasmic vesicle;transport vesicle membrane;cytoplasmic vesicle membrane;clathrin vesicle coat;vesicle coat;cell part;cell;intracellular;sorting endosome;clathrin coat of trans-Golgi network vesicle;transport vesicle;coated vesicle;clathrin-coated vesicle;spindle;extracellular exosome;whole membrane;microtubule cytoskeleton;Golgi subcompartment;extracellular vesicle;macromolecular complex;trans-Golgi network;cellular_component;membrane protein complex;extracellular region;endosome; 3;4;4;4;5;2;5;4;4;3;5;4;3;4;3;2;2;2;3;3;3;2;5;5;4;4;4;3;5;5;3;3;5;3;5;4;4;5;4;3;5;4;4;4;5;4;5;6;5;2;2;3;5;5;4;6;7;5;4;3;6;5;3;2;5;1;3;2;4; GO:0005198;GO:0003674;GO:0004871; structural molecule activity;molecular_function;signal transducer activity; 2;1;2; K04646 map04142;map04144;map04721;map04961;map05016;map05100; Lysosome;Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Huntington's disease;Bacterial invasion of epithelial cells; IPR016024;IPR011990;IPR016341;IPR001473;IPR000547;IPR022365;IPR015348;IPR012331; Armadillo-type fold;Tetratricopeptide-like helical domain;Clathrin, heavy chain;Clathrin, heavy chain, propeller, N-terminal;Clathrin, heavy chain/VPS, 7-fold repeat;Clathrin, heavy chain, propeller repeat;Clathrin, heavy chain, linker, core motif;Clathrin, heavy chain, linker; cytosol Hs9257202 3362.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q68D86 Coiled-coil domain-containing protein 102B OS=Homo sapiens OX=9606 GN=CCDC102B PE=1 SV=4 - [C102B_HUMAN] 0.931 0.878 1.439 0.889 0.988 0.843 1.060364465 nan 0.899797571 nan 1.638952164 nan 0.853238866 nan cytosol O60462 Neuropilin-2 OS=Homo sapiens OX=9606 GN=NRP2 PE=1 SV=3 - [NRP2_HUMAN] 1.042 1.122 1.004 1.04 1.008 0.947 0.928698752 nan 1.031746032 nan 0.89483066 nan 0.939484127 nan GO:0048675;GO:0048589;GO:0048588;GO:0048468;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0032989;GO:0071840;GO:0051716;GO:0042330;GO:0048869;GO:0048513;GO:0048514;GO:0048518;GO:0042127;GO:0030154;GO:1990138;GO:0061548;GO:0061549;GO:0097485;GO:0010631;GO:0010634;GO:0044700;GO:0044707;GO:0009605;GO:0048870;GO:0071526;GO:0006928;GO:0010594;GO:0048485;GO:0031175;GO:0097491;GO:0097490;GO:0043542;GO:0000904;GO:0016049;GO:0000902;GO:0001568;GO:0016043;GO:0065007;GO:0016477;GO:0048646;GO:0061564;GO:0009888;GO:0050794;GO:0008150;GO:0051239;GO:0048010;GO:0050896;GO:0050679;GO:0048812;GO:2000145;GO:2000147;GO:0023052;GO:0007154;GO:0007411;GO:0001667;GO:0009653;GO:0044699;GO:0051240;GO:0001944;GO:1902284;GO:1902285;GO:0060560;GO:0010632;GO:0032502;GO:0090130;GO:0032501;GO:0008283;GO:0009987;GO:0040012;GO:0007409;GO:0021675;GO:0032879;GO:0090132;GO:0032990;GO:0022610;GO:0050678;GO:0040017;GO:0050673;GO:0051674;GO:0048731;GO:0048483;GO:0008284;GO:0030030;GO:0001525;GO:0007275;GO:0006935;GO:0040007;GO:0048846;GO:0050789;GO:0048666;GO:0048667;GO:0030335;GO:0030334;GO:0030182;GO:0044767;GO:0044763;GO:0007155;GO:0042221;GO:0022008;GO:0051179;GO:0040011;GO:0051272;GO:0048699;GO:0051270;GO:0010595;GO:0048858;GO:0007399;GO:0001936;GO:0048856;GO:0001938;GO:0001935;GO:0048522; axon extension;developmental growth;developmental cell growth;cell development;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;taxis;cellular developmental process;animal organ development;blood vessel morphogenesis;positive regulation of biological process;regulation of cell proliferation;cell differentiation;neuron projection extension;ganglion development;sympathetic ganglion development;neuron projection guidance;epithelial cell migration;positive regulation of epithelial cell migration;single organism signaling;single-multicellular organism process;response to external stimulus;cell motility;semaphorin-plexin signaling pathway;movement of cell or subcellular component;regulation of endothelial cell migration;sympathetic nervous system development;neuron projection development;sympathetic neuron projection guidance;sympathetic neuron projection extension;endothelial cell migration;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;blood vessel development;cellular component organization;biological regulation;cell migration;anatomical structure formation involved in morphogenesis;axon development;tissue development;regulation of cellular process;biological_process;regulation of multicellular organismal process;vascular endothelial growth factor receptor signaling pathway;response to stimulus;positive regulation of epithelial cell proliferation;neuron projection morphogenesis;regulation of cell motility;positive regulation of cell motility;signaling;cell communication;axon guidance;ameboidal-type cell migration;anatomical structure morphogenesis;single-organism process;positive regulation of multicellular organismal process;vasculature development;neuron projection extension involved in neuron projection guidance;semaphorin-plexin signaling pathway involved in neuron projection guidance;developmental growth involved in morphogenesis;regulation of epithelial cell migration;developmental process;tissue migration;multicellular organismal process;cell proliferation;cellular process;regulation of locomotion;axonogenesis;nerve development;regulation of localization;epithelium migration;cell part morphogenesis;biological adhesion;regulation of epithelial cell proliferation;positive regulation of locomotion;epithelial cell proliferation;localization of cell;system development;autonomic nervous system development;positive regulation of cell proliferation;cell projection organization;angiogenesis;multicellular organism development;chemotaxis;growth;axon extension involved in axon guidance;regulation of biological process;neuron development;cell morphogenesis involved in neuron differentiation;positive regulation of cell migration;regulation of cell migration;neuron differentiation;single-organism developmental process;single-organism cellular process;cell adhesion;response to chemical;neurogenesis;localization;locomotion;positive regulation of cellular component movement;generation of neurons;regulation of cellular component movement;positive regulation of endothelial cell migration;cell projection morphogenesis;nervous system development;regulation of endothelial cell proliferation;anatomical structure development;positive regulation of endothelial cell proliferation;endothelial cell proliferation;positive regulation of cellular process; 6;3;4;4;5;5;4;5;6;7;4;2;3;3;4;4;4;2;4;5;5;5;6;5;6;4;3;3;3;3;6;4;5;5;5;6;6;7;5;3;5;4;3;2;4;3;6;4;3;1;3;8;2;5;6;4;4;2;4;6;5;3;2;3;5;6;6;4;4;2;4;2;3;2;3;7;4;3;5;5;2;5;3;4;3;4;5;4;4;4;4;4;2;7;2;5;6;5;5;6;3;3;3;3;6;2;2;4;7;4;5;5;5;6;3;6;5;3; GO:0016021;GO:0016020;GO:0032991;GO:0043234;GO:0044425;GO:0031224;GO:0002116;GO:0044464;GO:0005623;GO:0071944;GO:0005886;GO:0005575;GO:0005576;GO:0043235; integral component of membrane;membrane;macromolecular complex;protein complex;membrane part;intrinsic component of membrane;semaphorin receptor complex;cell part;cell;cell periphery;plasma membrane;cellular_component;extracellular region;receptor complex; 4;2;2;3;2;3;5;2;2;3;3;1;2;4; GO:0060089;GO:0008201;GO:0004714;GO:0004713;GO:0046872;GO:0097367;GO:0099600;GO:0003674;GO:0005488;GO:0019838;GO:1901681;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0005539;GO:0019955;GO:0043168;GO:0043169;GO:0016740;GO:0043167;GO:0017154;GO:0005021;GO:0005515;GO:0038023;GO:0004872;GO:0004871;GO:0004672;GO:0004888;GO:0019199; molecular transducer activity;heparin binding;transmembrane receptor protein tyrosine kinase activity;protein tyrosine kinase activity;metal ion binding;carbohydrate derivative binding;transmembrane receptor activity;molecular_function;binding;growth factor binding;sulfur compound binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;glycosaminoglycan binding;cytokine binding;anion binding;cation binding;transferase activity;ion binding;semaphorin receptor activity;vascular endothelial growth factor-activated receptor activity;protein binding;signaling receptor activity;receptor activity;signal transducer activity;protein kinase activity;transmembrane signaling receptor activity;transmembrane receptor protein kinase activity; 2;4;6;7;5;3;4;1;2;4;3;5;2;5;4;4;4;4;4;3;3;5;7;3;3;3;2;6;4;5; K06819 IPR000998;IPR022579;IPR013320;IPR000859;IPR000421;IPR008979;IPR014648;IPR027143; MAM domain;Neuropilin, C-terminal;Concanavalin A-like lectin/glucanase domain;CUB domain;Coagulation factor 5/8 C-terminal domain;Galactose-binding domain-like;Neuropilin;Neuropilin-2; peroxisome 379732309 57.4 O [O] Posttranslational modification, protein turnover, chaperones; COG4935 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases Q9HCX3 Zinc finger protein 304 OS=Homo sapiens OX=9606 GN=ZNF304 PE=1 SV=2 - [ZN304_HUMAN] 0.936 1.073 1.218 1.034 0.934 0.881 0.872320596 nan 1.107066381 nan 1.135135135 nan 0.943254818 nan GO:0006479;GO:0080090;GO:0019222;GO:2000113;GO:0072359;GO:0072358;GO:0007166;GO:0031056;GO:0051567;GO:0031058;GO:1901362;GO:0071840;GO:0032774;GO:0044710;GO:0010605;GO:0010604;GO:0051254;GO:0090309;GO:0043067;GO:0018193;GO:0016458;GO:0048514;GO:0044092;GO:0048518;GO:0016571;GO:0042127;GO:0044700;GO:0060255;GO:0060548;GO:0031060;GO:0031062;GO:2001141;GO:0035561;GO:0035562;GO:0046483;GO:0070734;GO:0044707;GO:0048870;GO:0018205;GO:0010638;GO:0040029;GO:0019538;GO:0051272;GO:1900114;GO:0010629;GO:0019438;GO:0016568;GO:0016569;GO:0051252;GO:0009892;GO:0009893;GO:0018023;GO:0018022;GO:0051100;GO:0006928;GO:0051674;GO:0035556;GO:0050673;GO:0050789;GO:0097659;GO:0044267;GO:0044260;GO:0006357;GO:0001568;GO:0016043;GO:0065007;GO:0016570;GO:1903308;GO:0006366;GO:1900112;GO:0065009;GO:0032259;GO:0048646;GO:0018130;GO:0051130;GO:0006139;GO:0050793;GO:0051240;GO:0009889;GO:0051716;GO:0050794;GO:0012501;GO:0043412;GO:0036211;GO:0043414;GO:0008152;GO:0034654;GO:0016070;GO:1902679;GO:0044271;GO:0050896;GO:0031401;GO:0061087;GO:0006355;GO:0061085;GO:0010556;GO:2000145;GO:0006351;GO:2000147;GO:0008150;GO:2001252;GO:1903310;GO:0033044;GO:0031937;GO:0031935;GO:0051239;GO:0033043;GO:0001944;GO:0006342;GO:0051128;GO:0098532;GO:0034641;GO:0023052;GO:0007165;GO:0034645;GO:0009653;GO:0044699;GO:2000209;GO:1904018;GO:0009890;GO:0061647;GO:0036124;GO:0010557;GO:0022603;GO:0051246;GO:0051247;GO:0031327;GO:0034968;GO:0032270;GO:0031399;GO:0008284;GO:0040011;GO:0032501;GO:2000811;GO:0008283;GO:1902464;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0040012;GO:0045892;GO:0045893;GO:0043276;GO:0048519;GO:0032879;GO:0009891;GO:0030334;GO:0090304;GO:0032268;GO:0050678;GO:0050679;GO:0051094;GO:0051253;GO:0051098;GO:1901342;GO:0043170;GO:1902680;GO:0006807;GO:0045944;GO:0048731;GO:0007229;GO:1902275;GO:0032502;GO:0006346;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:1902466;GO:0008213;GO:0016477;GO:0008219;GO:0001525;GO:0090308;GO:0007275;GO:0010628;GO:0010941;GO:0006325;GO:0042981;GO:1901360;GO:2000112;GO:0045765;GO:0045766;GO:1903508;GO:0071704;GO:0010467;GO:0043066;GO:0045814;GO:0043069;GO:0010468;GO:0030335;GO:0045935;GO:0045934;GO:1901576;GO:0019219;GO:0006915;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0051570;GO:0007154;GO:0007265;GO:0007264;GO:0051574;GO:0051179;GO:0060968;GO:0006996;GO:0044238;GO:0051270;GO:0051276;GO:0040017;GO:0048856;GO:0044237;GO:0010558;GO:1902589;GO:2000026;GO:0044249;GO:0048523;GO:0048522; protein methylation;regulation of primary metabolic process;regulation of metabolic process;negative regulation of cellular macromolecule biosynthetic process;circulatory system development;cardiovascular system development;cell surface receptor signaling pathway;regulation of histone modification;histone H3-K9 methylation;positive regulation of histone modification;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;RNA biosynthetic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;positive regulation of RNA metabolic process;positive regulation of methylation-dependent chromatin silencing;regulation of programmed cell death;peptidyl-amino acid modification;gene silencing;blood vessel morphogenesis;negative regulation of molecular function;positive regulation of biological process;histone methylation;regulation of cell proliferation;single organism signaling;regulation of macromolecule metabolic process;negative regulation of cell death;regulation of histone methylation;positive regulation of histone methylation;regulation of RNA biosynthetic process;regulation of chromatin binding;negative regulation of chromatin binding;heterocycle metabolic process;histone H3-K27 methylation;single-multicellular organism process;cell motility;peptidyl-lysine modification;positive regulation of organelle organization;regulation of gene expression, epigenetic;protein metabolic process;positive regulation of cellular component movement;positive regulation of histone H3-K9 trimethylation;negative regulation of gene expression;aromatic compound biosynthetic process;chromatin modification;covalent chromatin modification;regulation of RNA metabolic process;negative regulation of metabolic process;positive regulation of metabolic process;peptidyl-lysine trimethylation;peptidyl-lysine methylation;negative regulation of binding;movement of cell or subcellular component;localization of cell;intracellular signal transduction;epithelial cell proliferation;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;blood vessel development;cellular component organization;biological regulation;histone modification;regulation of chromatin modification;transcription from RNA polymerase II promoter;regulation of histone H3-K9 trimethylation;regulation of molecular function;methylation;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;positive regulation of cellular component organization;nucleobase-containing compound metabolic process;regulation of developmental process;positive regulation of multicellular organismal process;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;programmed cell death;macromolecule modification;protein modification process;macromolecule methylation;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;positive regulation of protein modification process;positive regulation of histone H3-K27 methylation;regulation of transcription, DNA-templated;regulation of histone H3-K27 methylation;regulation of macromolecule biosynthetic process;regulation of cell motility;transcription, DNA-templated;positive regulation of cell motility;biological_process;positive regulation of chromosome organization;positive regulation of chromatin modification;regulation of chromosome organization;positive regulation of chromatin silencing;regulation of chromatin silencing;regulation of multicellular organismal process;regulation of organelle organization;vasculature development;chromatin silencing;regulation of cellular component organization;histone H3-K27 trimethylation;cellular nitrogen compound metabolic process;signaling;signal transduction;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;regulation of anoikis;positive regulation of vasculature development;negative regulation of biosynthetic process;histone H3-K9 modification;histone H3-K9 trimethylation;positive regulation of macromolecule biosynthetic process;regulation of anatomical structure morphogenesis;regulation of protein metabolic process;positive regulation of protein metabolic process;negative regulation of cellular biosynthetic process;histone lysine methylation;positive regulation of cellular protein metabolic process;regulation of protein modification process;positive regulation of cell proliferation;locomotion;multicellular organismal process;negative regulation of anoikis;cell proliferation;regulation of histone H3-K27 trimethylation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;regulation of locomotion;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;anoikis;negative regulation of biological process;regulation of localization;positive regulation of biosynthetic process;regulation of cell migration;nucleic acid metabolic process;regulation of cellular protein metabolic process;regulation of epithelial cell proliferation;positive regulation of epithelial cell proliferation;positive regulation of developmental process;negative regulation of RNA metabolic process;regulation of binding;regulation of vasculature development;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;system development;integrin-mediated signaling pathway;regulation of chromatin organization;developmental process;methylation-dependent chromatin silencing;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of histone H3-K27 trimethylation;protein alkylation;cell migration;cell death;angiogenesis;regulation of methylation-dependent chromatin silencing;multicellular organism development;positive regulation of gene expression;regulation of cell death;chromatin organization;regulation of apoptotic process;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of angiogenesis;positive regulation of angiogenesis;positive regulation of nucleic acid-templated transcription;organic substance metabolic process;gene expression;negative regulation of apoptotic process;negative regulation of gene expression, epigenetic;negative regulation of programmed cell death;regulation of gene expression;positive regulation of cell migration;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;regulation of histone H3-K9 methylation;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;positive regulation of histone H3-K9 methylation;localization;regulation of gene silencing;organelle organization;primary metabolic process;regulation of cellular component movement;chromosome organization;positive regulation of locomotion;anatomical structure development;cellular metabolic process;negative regulation of macromolecule biosynthetic process;single-organism organelle organization;regulation of multicellular organismal development;cellular biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 5;4;3;6;5;5;5;5;6;5;5;2;6;3;4;4;5;6;5;7;4;4;4;2;5;4;3;4;4;6;6;6;5;6;4;7;3;3;8;5;6;4;4;8;5;5;6;7;5;3;3;7;6;5;4;3;5;4;2;7;5;4;7;4;3;2;4;7;7;8;3;3;3;5;4;4;3;3;4;3;3;5;5;5;4;2;5;5;6;5;2;6;7;6;7;5;4;6;4;1;6;7;6;6;5;3;5;5;5;4;8;4;2;4;5;3;2;7;4;4;5;7;5;4;5;5;5;6;5;6;4;2;2;7;3;8;2;4;7;7;3;6;6;7;2;3;4;5;5;5;5;5;3;5;4;5;4;6;3;7;4;6;6;2;5;5;4;5;4;4;4;8;7;4;4;4;6;4;5;4;5;6;4;6;5;5;7;3;5;6;6;5;5;5;5;5;4;5;6;6;3;3;5;3;4;4;4;7;4;7;6;7;2;4;4;3;4;5;3;3;3;5;4;4;4;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005622;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;organelle;intracellular;cellular_component; 4;3;3;3;5;2;2;2;3;1; GO:0001071;GO:1990837;GO:0046872;GO:0044877;GO:0001067;GO:0044212;GO:0001012;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901363;GO:0097159;GO:1990841;GO:0000975;GO:0043169;GO:0043167;GO:0043565;GO:0003690;GO:0003682;GO:0000976;GO:0000977;GO:0003700; nucleic acid binding transcription factor activity;sequence-specific double-stranded DNA binding;metal ion binding;macromolecular complex binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;heterocyclic compound binding;organic cyclic compound binding;promoter-specific chromatin binding;regulatory region DNA binding;cation binding;ion binding;sequence-specific DNA binding;double-stranded DNA binding;chromatin binding;transcription regulatory region sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 2;7;5;3;5;7;8;1;2;4;5;3;3;5;6;4;3;6;6;4;8;9;3; K09228 IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs10190696 1350.0 R [R] General function prediction only; P08254 Stromelysin-1 OS=Homo sapiens OX=9606 GN=MMP3 PE=1 SV=2 - [MMP3_HUMAN] 0.779 1.336 0.422 2.405 0.726 0.815 0.583083832 nan 3.312672176 nan 0.315868263 nan 1.122589532 nan GO:0019222;GO:0048584;GO:0048583;GO:0044710;GO:0071840;GO:0044712;GO:0051716;GO:0010310;GO:0010727;GO:1903201;GO:0048518;GO:0048519;GO:1903209;GO:0036473;GO:0010035;GO:0044707;GO:0019538;GO:0030198;GO:0033554;GO:0022607;GO:0009892;GO:0000302;GO:0080134;GO:0050789;GO:0016043;GO:0065003;GO:0065007;GO:0044699;GO:0051130;GO:2000378;GO:2000377;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0043254;GO:0050896;GO:1901699;GO:0030574;GO:0022411;GO:0044085;GO:0070271;GO:0071241;GO:0051128;GO:0070887;GO:0032963;GO:0044243;GO:1902884;GO:1902882;GO:0006508;GO:0022617;GO:0032501;GO:0044238;GO:0009987;GO:0031334;GO:0072593;GO:0044259;GO:0006979;GO:0051259;GO:1900407;GO:1900409;GO:0043170;GO:0042743;GO:1901698;GO:0043933;GO:0031324;GO:0031323;GO:0010942;GO:0008219;GO:0010941;GO:0071822;GO:0071704;GO:0043062;GO:0032461;GO:1902170;GO:0006461;GO:0034614;GO:0044763;GO:0042221;GO:0034599;GO:0009056;GO:1901700;GO:1901701;GO:0071731;GO:0071732;GO:0044237;GO:0044236;GO:0044087;GO:0080135;GO:0032459;GO:0048522;GO:0048523;GO:0044089; regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;cellular component organization or biogenesis;single-organism catabolic process;cellular response to stimulus;regulation of hydrogen peroxide metabolic process;negative regulation of hydrogen peroxide metabolic process;regulation of oxidative stress-induced cell death;positive regulation of biological process;negative regulation of biological process;positive regulation of oxidative stress-induced cell death;cell death in response to oxidative stress;response to inorganic substance;single-multicellular organism process;protein metabolic process;extracellular matrix organization;cellular response to stress;cellular component assembly;negative regulation of metabolic process;response to reactive oxygen species;regulation of response to stress;regulation of biological process;cellular component organization;macromolecular complex assembly;biological regulation;single-organism process;positive regulation of cellular component organization;negative regulation of reactive oxygen species metabolic process;regulation of reactive oxygen species metabolic process;regulation of cellular process;response to stress;biological_process;metabolic process;regulation of protein complex assembly;response to stimulus;cellular response to nitrogen compound;collagen catabolic process;cellular component disassembly;cellular component biogenesis;protein complex biogenesis;cellular response to inorganic substance;regulation of cellular component organization;cellular response to chemical stimulus;collagen metabolic process;multicellular organism catabolic process;positive regulation of response to oxidative stress;regulation of response to oxidative stress;proteolysis;extracellular matrix disassembly;multicellular organismal process;primary metabolic process;cellular process;positive regulation of protein complex assembly;reactive oxygen species metabolic process;multicellular organismal macromolecule metabolic process;response to oxidative stress;protein oligomerization;regulation of cellular response to oxidative stress;positive regulation of cellular response to oxidative stress;macromolecule metabolic process;hydrogen peroxide metabolic process;response to nitrogen compound;macromolecular complex subunit organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of cell death;cell death;regulation of cell death;protein complex subunit organization;organic substance metabolic process;extracellular structure organization;positive regulation of protein oligomerization;cellular response to reactive nitrogen species;protein complex assembly;cellular response to reactive oxygen species;single-organism cellular process;response to chemical;cellular response to oxidative stress;catabolic process;response to oxygen-containing compound;cellular response to oxygen-containing compound;response to nitric oxide;cellular response to nitric oxide;cellular metabolic process;multicellular organism metabolic process;regulation of cellular component biogenesis;regulation of cellular response to stress;regulation of protein oligomerization;positive regulation of cellular process;negative regulation of cellular process;positive regulation of cellular component biogenesis; 3;3;3;3;2;4;3;6;6;5;2;2;5;5;4;3;4;5;4;4;3;5;4;2;3;5;2;2;4;5;5;3;3;1;2;4;2;5;5;4;3;4;5;4;4;6;5;4;5;5;5;2;3;2;4;4;5;4;6;5;4;4;5;4;4;4;4;4;4;4;5;3;4;5;6;5;6;3;3;5;3;4;5;5;6;3;4;3;4;5;3;3;3; GO:0044421;GO:0031012;GO:0005615;GO:0005575;GO:0005576;GO:0005578; extracellular region part;extracellular matrix;extracellular space;cellular_component;extracellular region;proteinaceous extracellular matrix; 2;2;3;1;2;3; GO:0008270;GO:0046872;GO:0004222;GO:0003674;GO:0005488;GO:0046914;GO:0016787;GO:0003824;GO:0008233;GO:0008237;GO:0043169;GO:0043167;GO:0005509;GO:0004175;GO:0070011; zinc ion binding;metal ion binding;metalloendopeptidase activity;molecular_function;binding;transition metal ion binding;hydrolase activity;catalytic activity;peptidase activity;metallopeptidase activity;cation binding;ion binding;calcium ion binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 7;5;7;1;2;6;3;2;4;6;4;3;6;6;5; K01394 map04668;map05202;map05323; TNF signaling pathway;Transcriptional misregulation in cancer;Rheumatoid arthritis; IPR018487;IPR018486;IPR000585;IPR033739;IPR021190;IPR028700;IPR001818;IPR002477;IPR024079;IPR006026;IPR021158; Hemopexin-like repeats;Hemopexin, conserved site;Hemopexin-like domain;Peptidase M10A, catalytic domain;Peptidase M10A;Stromelysin 1;Peptidase M10, metallopeptidase;Peptidoglycan binding-like;Metallopeptidase, catalytic domain;Peptidase, metallopeptidase;Peptidase M10A, cysteine switch, zinc binding site; extracellular Hs4505217 986.0 OW [O] Posttranslational modification, protein turnover, chaperones;[W] Extracellular structures; Q5TEC3 Zinc finger protein 697 OS=Homo sapiens OX=9606 GN=ZNF697 PE=1 SV=2 - [ZN697_HUMAN] 0.888 1.014 1.63 1.117 0.731 nan 0.875739645 nan 1.528043776 nan 1.607495069 nan nan nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; IPR013087; Zinc finger C2H2-type; nucleus Hs14726886 347.0 R [R] General function prediction only; P84996 Protein ALEX OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=1 - [ALEX_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0016337;GO:0048589;GO:0098602;GO:0050890;GO:0060429;GO:0048583;GO:0060348;GO:0007596;GO:0001501;GO:0022404;GO:0023052;GO:0007165;GO:0023051;GO:0008544;GO:0007599;GO:0098773;GO:0010646;GO:0050789;GO:0044699;GO:0009653;GO:0040007;GO:0009966;GO:0071697;GO:0001942;GO:0009611;GO:0007275;GO:0007188;GO:0048513;GO:0065007;GO:0009888;GO:0034109;GO:0022610;GO:0007186;GO:0007187;GO:0048646;GO:0060788;GO:0032502;GO:0032501;GO:0070527;GO:0050878;GO:0098609;GO:0050877;GO:0009987;GO:0042633;GO:0051716;GO:0042060;GO:0044767;GO:0001775;GO:0050817;GO:0008150;GO:0048731;GO:0007155;GO:0007154;GO:0007189;GO:0050794;GO:0042303;GO:0071696;GO:0030168;GO:0003008;GO:0060789;GO:0044700;GO:0065008;GO:0044707;GO:0050896;GO:0048856;GO:0006950;GO:0022405;GO:0043588;GO:0044763; single organismal cell-cell adhesion;developmental growth;single organism cell adhesion;cognition;epithelium development;regulation of response to stimulus;bone development;blood coagulation;skeletal system development;molting cycle process;signaling;signal transduction;regulation of signaling;epidermis development;hemostasis;skin epidermis development;regulation of cell communication;regulation of biological process;single-organism process;anatomical structure morphogenesis;growth;regulation of signal transduction;ectodermal placode morphogenesis;hair follicle development;response to wounding;multicellular organism development;adenylate cyclase-modulating G-protein coupled receptor signaling pathway;animal organ development;biological regulation;tissue development;homotypic cell-cell adhesion;biological adhesion;G-protein coupled receptor signaling pathway;G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;anatomical structure formation involved in morphogenesis;ectodermal placode formation;developmental process;multicellular organismal process;platelet aggregation;regulation of body fluid levels;cell-cell adhesion;neurological system process;cellular process;hair cycle;cellular response to stimulus;wound healing;single-organism developmental process;cell activation;coagulation;biological_process;system development;cell adhesion;cell communication;adenylate cyclase-activating G-protein coupled receptor signaling pathway;regulation of cellular process;molting cycle;ectodermal placode development;platelet activation;system process;hair follicle placode formation;single organism signaling;regulation of biological quality;single-multicellular organism process;response to stimulus;anatomical structure development;response to stress;hair cycle process;skin development;single-organism cellular process; 4;3;3;5;5;3;4;5;5;4;2;4;3;6;5;6;4;2;2;3;2;4;4;4;4;4;7;4;2;4;5;2;5;6;3;4;2;2;6;4;4;4;2;5;3;5;3;4;4;1;4;3;4;8;3;4;4;5;3;5;3;3;3;2;3;3;5;5;3; GO:0005886;GO:0071944;GO:0005737;GO:0001726;GO:0042995;GO:0016020;GO:0031252;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0005829; plasma membrane;cell periphery;cytoplasm;ruffle;cell projection;membrane;cell leading edge;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;cytosol; 3;3;4;4;3;2;3;2;2;3;1;4;3;5; nucleus 326803138 58.9 D [D] Cell cycle control, cell division, chromosome partitioning; COG3266 Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain Q9Y673 Dolichyl-phosphate beta-glucosyltransferase OS=Homo sapiens OX=9606 GN=ALG5 PE=1 SV=1 - [ALG5_HUMAN] 0.831 1.238 0.759 1.564 0.966 0.904 0.671243942 0.099611364 1.619047619 0.104419043 0.613085622 0.021685185 0.935817805 0.93916496 GO:0044281;GO:0035268;GO:0035269;GO:0044710;GO:0044711;GO:0007368;GO:0018193;GO:0006661;GO:0006664;GO:0046488;GO:0046486;GO:0044707;GO:0019538;GO:0019348;GO:0042157;GO:0042158;GO:1901576;GO:0044260;GO:0019637;GO:0006629;GO:0070085;GO:0007389;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0090407;GO:0043413;GO:1901615;GO:0018196;GO:0016093;GO:0044249;GO:0034645;GO:0009799;GO:0044699;GO:0006505;GO:0006506;GO:0046467;GO:0032502;GO:1903509;GO:0006644;GO:0032501;GO:0006643;GO:0006720;GO:0043687;GO:0009987;GO:0009247;GO:0006493;GO:0044255;GO:1901137;GO:1901135;GO:0008654;GO:0043170;GO:0006066;GO:0046474;GO:0006650;GO:0009100;GO:0007275;GO:0045017;GO:0006486;GO:0006487;GO:0006488;GO:0009101;GO:0071704;GO:0018279;GO:0044267;GO:0006793;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0008610;GO:0006497;GO:0044238;GO:0005975;GO:0006490;GO:0048856;GO:0097502;GO:0044237;GO:0006796;GO:0009855; small molecule metabolic process;protein mannosylation;protein O-linked mannosylation;single-organism metabolic process;single-organism biosynthetic process;determination of left/right symmetry;peptidyl-amino acid modification;phosphatidylinositol biosynthetic process;glycolipid metabolic process;phosphatidylinositol metabolic process;glycerolipid metabolic process;single-multicellular organism process;protein metabolic process;dolichol metabolic process;lipoprotein metabolic process;lipoprotein biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;organophosphate metabolic process;lipid metabolic process;glycosylation;pattern specification process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;organophosphate biosynthetic process;macromolecule glycosylation;organic hydroxy compound metabolic process;peptidyl-asparagine modification;polyprenol metabolic process;cellular biosynthetic process;cellular macromolecule biosynthetic process;specification of symmetry;single-organism process;GPI anchor metabolic process;GPI anchor biosynthetic process;membrane lipid biosynthetic process;developmental process;liposaccharide metabolic process;phospholipid metabolic process;multicellular organismal process;membrane lipid metabolic process;isoprenoid metabolic process;post-translational protein modification;cellular process;glycolipid biosynthetic process;protein O-linked glycosylation;cellular lipid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;phospholipid biosynthetic process;macromolecule metabolic process;alcohol metabolic process;glycerophospholipid biosynthetic process;glycerophospholipid metabolic process;glycoprotein metabolic process;multicellular organism development;glycerolipid biosynthetic process;protein glycosylation;protein N-linked glycosylation;dolichol-linked oligosaccharide biosynthetic process;glycoprotein biosynthetic process;organic substance metabolic process;protein N-linked glycosylation via asparagine;cellular protein metabolic process;phosphorus metabolic process;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;lipid biosynthetic process;protein lipidation;primary metabolic process;carbohydrate metabolic process;oligosaccharide-lipid intermediate biosynthetic process;anatomical structure development;mannosylation;cellular metabolic process;phosphate-containing compound metabolic process;determination of bilateral symmetry; 4;5;6;3;4;7;7;7;6;7;5;3;4;7;5;6;4;4;4;4;5;4;5;5;1;2;4;5;6;4;8;6;4;5;5;2;7;7;5;2;5;5;2;5;5;7;2;6;5;4;5;4;5;4;5;6;6;5;4;5;4;5;6;6;3;6;5;4;6;3;3;5;3;5;7;3;4;5;3;6;3;5;6; GO:0005783;GO:0005789;GO:0016020;GO:0098588;GO:0043231;GO:0042175;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0031224;GO:0012505;GO:0044425;GO:0044446;GO:0044444;GO:0016021;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;membrane;bounding membrane of organelle;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;intrinsic component of membrane;endomembrane system;membrane part;intracellular organelle part;cytoplasmic part;integral component of membrane;cytoplasm;organelle membrane;cell part;cell;cellular_component; 4;3;2;4;4;3;3;2;3;3;3;2;4;3;3;2;3;4;4;4;3;2;2;1; GO:0016740;GO:0004582;GO:0016757;GO:0016758;GO:0003674;GO:0046527;GO:0035251;GO:0000030;GO:0003824;GO:0004581;GO:0004169;GO:0008194;GO:0004576; transferase activity;dolichyl-phosphate beta-D-mannosyltransferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;molecular_function;glucosyltransferase activity;UDP-glucosyltransferase activity;mannosyltransferase activity;catalytic activity;dolichyl-phosphate beta-glucosyltransferase activity;dolichyl-phosphate-mannose-protein mannosyltransferase activity;UDP-glycosyltransferase activity;oligosaccharyl transferase activity; 3;7;4;5;1;6;6;6;2;7;7;5;6; K00729 map00510;map01100; N-Glycan biosynthesis;Metabolic pathways; IPR035518;IPR001173;IPR029044; Dolichyl-phosphate beta-glucosyltransferase;Glycosyltransferase 2-like;Nucleotide-diphospho-sugar transferases; endoplasmic reticulum Hs7019323 672.0 R [R] General function prediction only; A0A075B6H9 Immunoglobulin lambda variable 4-69 OS=Homo sapiens OX=9606 GN=IGLV4-69 PE=1 SV=1 - [LV469_HUMAN] 1.238 0.953 1.024 0.903 0.868 1.288 1.299055614 0.002791331 1.040322581 0.392169677 1.074501574 0.024134607 1.483870968 0.001627571 IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular O00391 Sulfhydryl oxidase 1 OS=Homo sapiens OX=9606 GN=QSOX1 PE=1 SV=3 - [QSOX1_HUMAN] 0.98 1.179 0.919 1.007 1.151 0.942 0.831212892 nan 0.874891399 nan 0.779474131 nan 0.818418766 nan GO:0019222;GO:0048585;GO:0048583;GO:0051716;GO:0048519;GO:0019725;GO:0009605;GO:0031667;GO:0016242;GO:0033554;GO:0010648;GO:0009894;GO:0009895;GO:0006457;GO:0065007;GO:0044699;GO:0065008;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0050896;GO:0080135;GO:0032107;GO:0032104;GO:0032105;GO:0032102;GO:0032101;GO:0032108;GO:0044248;GO:0009892;GO:0010646;GO:0031330;GO:0016236;GO:0009987;GO:0045454;GO:0080134;GO:0009991;GO:0031329;GO:0031324;GO:0031323;GO:0042592;GO:0050789;GO:0010506;GO:0010507;GO:0016241;GO:0006914;GO:0044763;GO:0007154;GO:0009056;GO:0044237;GO:0048523; regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;cellular response to stimulus;negative regulation of biological process;cellular homeostasis;response to external stimulus;response to nutrient levels;negative regulation of macroautophagy;cellular response to stress;negative regulation of cell communication;regulation of catabolic process;negative regulation of catabolic process;protein folding;biological regulation;single-organism process;regulation of biological quality;regulation of cellular process;response to stress;biological_process;metabolic process;response to stimulus;regulation of cellular response to stress;regulation of response to nutrient levels;regulation of response to extracellular stimulus;negative regulation of response to extracellular stimulus;negative regulation of response to external stimulus;regulation of response to external stimulus;negative regulation of response to nutrient levels;cellular catabolic process;negative regulation of metabolic process;regulation of cell communication;negative regulation of cellular catabolic process;macroautophagy;cellular process;cell redox homeostasis;regulation of response to stress;response to extracellular stimulus;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;homeostatic process;regulation of biological process;regulation of autophagy;negative regulation of autophagy;regulation of macroautophagy;autophagy;single-organism cellular process;cell communication;catabolic process;cellular metabolic process;negative regulation of cellular process; 3;3;3;3;2;4;3;5;5;4;4;4;4;3;2;2;3;3;3;1;2;2;4;6;5;5;4;4;6;4;3;4;5;4;2;4;4;4;5;4;4;4;2;4;4;5;3;3;4;3;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0005794;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0030173;GO:0043227;GO:0043226;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0031228;GO:0031301;GO:0031300;GO:0031224;GO:0005737;GO:0045171;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0005615;GO:0044444;GO:1903561;GO:0070062;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;Golgi apparatus;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;integral component of Golgi membrane;membrane-bounded organelle;organelle;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;intrinsic component of Golgi membrane;integral component of organelle membrane;intrinsic component of organelle membrane;intrinsic component of membrane;cytoplasm;intercellular bridge;organelle membrane;cell part;cell;intracellular;extracellular space;cytoplasmic part;extracellular vesicle;extracellular exosome;cellular_component;extracellular region; 4;4;2;4;4;3;4;3;2;2;2;3;5;3;2;4;3;5;3;4;4;3;3;4;3;3;2;2;3;3;4;3;4;1;2; GO:0016864;GO:0016860;GO:0003674;GO:0016971;GO:0016972;GO:0003824;GO:0016670;GO:0016491;GO:0003756;GO:0016667;GO:0016853; intramolecular oxidoreductase activity, transposing S-S bonds;intramolecular oxidoreductase activity;molecular_function;flavin-linked sulfhydryl oxidase activity;thiol oxidase activity;catalytic activity;oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor;oxidoreductase activity;protein disulfide isomerase activity;oxidoreductase activity, acting on a sulfur group of donors;isomerase activity; 5;4;1;7;6;2;5;3;6;4;3; K10758 IPR013766;IPR017905;IPR012336; Thioredoxin domain;ERV/ALR sulfhydryl oxidase domain;Thioredoxin-like fold; Golgi apparatus Hs13325075 1535.0 D [D] Cell cycle control, cell division, chromosome partitioning; Q8IWV7 E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1 - [UBR1_HUMAN] 0.71 0.785 0.731 0.74 0.664 6.521 0.904458599 nan 1.114457831 nan 0.931210191 nan 9.820783133 nan GO:0048585;GO:0048583;GO:0043201;GO:0043200;GO:0051716;GO:0009968;GO:0048519;GO:0042221;GO:0030163;GO:0010033;GO:0044700;GO:0019538;GO:0009056;GO:0010243;GO:0007165;GO:0035556;GO:0043170;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0009719;GO:0065007;GO:0071596;GO:0050794;GO:0008150;GO:0008152;GO:1902532;GO:1902531;GO:0051603;GO:0050896;GO:1901699;GO:0009966;GO:0006511;GO:0043161;GO:0032007;GO:0032006;GO:0044248;GO:0023057;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0010646;GO:0044699;GO:0006508;GO:0071495;GO:0044238;GO:0009987;GO:0031929;GO:0001101;GO:0044257;GO:1901698;GO:0010498;GO:0071229;GO:0043632;GO:0071417;GO:0071704;GO:0071310;GO:0071230;GO:0071233;GO:0019941;GO:0044763;GO:0007154;GO:0009057;GO:1901700;GO:1901701;GO:0044260;GO:0044237;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;response to leucine;response to amino acid;cellular response to stimulus;negative regulation of signal transduction;negative regulation of biological process;response to chemical;protein catabolic process;response to organic substance;single organism signaling;protein metabolic process;catabolic process;response to organonitrogen compound;signal transduction;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;response to endogenous stimulus;biological regulation;ubiquitin-dependent protein catabolic process via the N-end rule pathway;regulation of cellular process;biological_process;metabolic process;negative regulation of intracellular signal transduction;regulation of intracellular signal transduction;proteolysis involved in cellular protein catabolic process;response to stimulus;cellular response to nitrogen compound;regulation of signal transduction;ubiquitin-dependent protein catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;negative regulation of TOR signaling;regulation of TOR signaling;cellular catabolic process;negative regulation of signaling;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;single-organism process;proteolysis;cellular response to endogenous stimulus;primary metabolic process;cellular process;TOR signaling;response to acid chemical;cellular protein catabolic process;response to nitrogen compound;proteasomal protein catabolic process;cellular response to acid chemical;modification-dependent macromolecule catabolic process;cellular response to organonitrogen compound;organic substance metabolic process;cellular response to organic substance;cellular response to amino acid stimulus;cellular response to leucine;modification-dependent protein catabolic process;single-organism cellular process;cell communication;macromolecule catabolic process;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular macromolecule metabolic process;cellular metabolic process;negative regulation of cellular process; 3;3;6;5;3;4;2;3;5;4;3;4;3;4;4;5;4;2;5;4;5;3;2;8;3;1;2;5;5;6;2;5;4;8;7;6;6;4;3;2;4;4;3;4;2;5;4;3;2;6;4;6;4;6;5;6;5;3;5;6;7;7;3;4;5;4;5;4;3;3; GO:1902494;GO:1990234;GO:0000502;GO:0043234;GO:0005829;GO:0000151;GO:0044424;GO:0005737;GO:0044444;GO:0044464;GO:0005623;GO:0005622;GO:0032991;GO:0005575; catalytic complex;transferase complex;proteasome complex;protein complex;cytosol;ubiquitin ligase complex;intracellular part;cytoplasm;cytoplasmic part;cell part;cell;intracellular;macromolecular complex;cellular_component; 4;5;4;3;5;4;3;4;4;2;2;3;2;1; GO:0008270;GO:0016597;GO:0070728;GO:0016740;GO:0046872;GO:0061659;GO:0003674;GO:0005488;GO:0046914;GO:0003824;GO:0004842;GO:0031406;GO:0043168;GO:0043169;GO:0016874;GO:0043167;GO:0043177;GO:0019787;GO:0036094;GO:0061630; zinc ion binding;amino acid binding;leucine binding;transferase activity;metal ion binding;ubiquitin-like protein ligase activity;molecular_function;binding;transition metal ion binding;catalytic activity;ubiquitin-protein transferase activity;carboxylic acid binding;anion binding;cation binding;ligase activity;ion binding;organic acid binding;ubiquitin-like protein transferase activity;small molecule binding;ubiquitin protein ligase activity; 7;6;5;3;5;5;1;2;6;2;5;5;4;4;3;3;4;4;3;6; K10625 IPR003126;IPR003769;IPR013083;IPR014719;IPR011991; Zinc finger, UBR-type;Adaptor protein ClpS, core;Zinc finger, RING/FYVE/PHD-type;Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like;Winged helix-turn-helix DNA-binding domain; plasma membrane Hs18597977 1353.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9H4L5 Oxysterol-binding protein-related protein 3 OS=Homo sapiens OX=9606 GN=OSBPL3 PE=1 SV=1 - [OSBL3_HUMAN] 0.733 0.856 1.545 0.965 1.101 0.611 0.856308411 nan 0.876475931 nan 1.804906542 nan 0.554950045 nan GO:0006869;GO:0044699;GO:0071702;GO:0033036;GO:0006810;GO:0044765;GO:0008150;GO:0051234;GO:0010876;GO:0051179;GO:1902578; lipid transport;single-organism process;organic substance transport;macromolecule localization;transport;single-organism transport;biological_process;establishment of localization;lipid localization;localization;single-organism localization; 5;2;5;3;4;4;1;3;4;2;3; GO:0005635;GO:0005783;GO:0031975;GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0005737;GO:0005575;GO:0042995;GO:0031090;GO:0005634;GO:0016020;GO:0044432;GO:0048471;GO:0031965;GO:0031967;GO:0012505;GO:0005886;GO:0043231;GO:0097038;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0044444;GO:0044428;GO:0044424;GO:0044422; nuclear envelope;endoplasmic reticulum;envelope;intracellular organelle;cell periphery;membrane-bounded organelle;organelle;cytoplasm;cellular_component;cell projection;organelle membrane;nucleus;membrane;endoplasmic reticulum part;perinuclear region of cytoplasm;nuclear membrane;organelle envelope;endomembrane system;plasma membrane;intracellular membrane-bounded organelle;perinuclear endoplasmic reticulum;cytosol;cell part;cell;intracellular;intracellular organelle part;cytoplasmic part;nuclear part;intracellular part;organelle part; 4;4;3;3;3;3;2;4;1;3;3;5;2;4;5;4;4;3;3;4;5;5;2;2;3;3;4;4;3;2; GO:0003674;GO:0005488;GO:0032934;GO:0008289;GO:0036094;GO:0005496;GO:0015485;GO:0043178;GO:0097159; molecular_function;binding;sterol binding;lipid binding;small molecule binding;steroid binding;cholesterol binding;alcohol binding;organic cyclic compound binding; 1;2;5;3;3;4;6;4;3; K20463 IPR000648;IPR001849;IPR018494;IPR011993; Oxysterol-binding protein;Pleckstrin homology domain;Oxysterol-binding protein, conserved site;PH domain-like; nucleus Hs14149704 1842.0 I [I] Lipid transport and metabolism; P40926 Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3 - [MDHM_HUMAN] 1.269 1.144 0.849 1.018 1.06 0.553 1.109265734 nan 0.960377358 nan 0.742132867 nan 0.521698113 nan GO:0006473;GO:0006475;GO:0044281;GO:0044283;GO:1901576;GO:0072350;GO:1901360;GO:0044710;GO:0044711;GO:0043436;GO:1901564;GO:0055114;GO:0046483;GO:0043648;GO:0019538;GO:0006807;GO:0046496;GO:0043170;GO:0044267;GO:0051186;GO:0044260;GO:0019637;GO:0019318;GO:0019319;GO:0043412;GO:0036211;GO:0045333;GO:0008152;GO:0044723;GO:0015980;GO:0006101;GO:0008150;GO:0006753;GO:0006108;GO:0019674;GO:0006732;GO:0006733;GO:0006734;GO:0034641;GO:0044699;GO:0006139;GO:0044763;GO:0009987;GO:0006725;GO:0055086;GO:0006082;GO:0005996;GO:0009060;GO:0006006;GO:0046364;GO:0019752;GO:0006099;GO:0006091;GO:0072524;GO:0006094;GO:0016051;GO:0006107;GO:0071704;GO:0043543;GO:0006464;GO:0009058;GO:0009117;GO:0044238;GO:0005975;GO:0044237;GO:0006796;GO:0006793;GO:0019362; protein acetylation;internal protein amino acid acetylation;small molecule metabolic process;small molecule biosynthetic process;organic substance biosynthetic process;tricarboxylic acid metabolic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;oxoacid metabolic process;organonitrogen compound metabolic process;oxidation-reduction process;heterocycle metabolic process;dicarboxylic acid metabolic process;protein metabolic process;nitrogen compound metabolic process;nicotinamide nucleotide metabolic process;macromolecule metabolic process;cellular protein metabolic process;cofactor metabolic process;cellular macromolecule metabolic process;organophosphate metabolic process;hexose metabolic process;hexose biosynthetic process;macromolecule modification;protein modification process;cellular respiration;metabolic process;single-organism carbohydrate metabolic process;energy derivation by oxidation of organic compounds;citrate metabolic process;biological_process;nucleoside phosphate metabolic process;malate metabolic process;NAD metabolic process;coenzyme metabolic process;oxidoreduction coenzyme metabolic process;NADH metabolic process;cellular nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;single-organism cellular process;cellular process;cellular aromatic compound metabolic process;nucleobase-containing small molecule metabolic process;organic acid metabolic process;monosaccharide metabolic process;aerobic respiration;glucose metabolic process;monosaccharide biosynthetic process;carboxylic acid metabolic process;tricarboxylic acid cycle;generation of precursor metabolites and energy;pyridine-containing compound metabolic process;gluconeogenesis;carbohydrate biosynthetic process;oxaloacetate metabolic process;organic substance metabolic process;protein acylation;cellular protein modification process;biosynthetic process;nucleotide metabolic process;primary metabolic process;carbohydrate metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;pyridine nucleotide metabolic process; 8;9;4;5;4;7;4;3;4;5;4;4;4;7;4;3;7;4;5;4;4;4;6;7;5;5;5;2;4;4;8;1;5;8;8;5;6;9;4;2;4;3;2;4;4;4;5;6;7;6;6;4;4;5;8;5;8;3;7;6;3;6;3;4;3;5;4;6; GO:0031974;GO:0031975;GO:0031982;GO:0031981;GO:0043209;GO:0016020;GO:0031967;GO:0031966;GO:0043230;GO:0043233;GO:0043231;GO:0044428;GO:0044429;GO:0044424;GO:0044421;GO:0044422;GO:0019866;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005634;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0071944;GO:0070062;GO:0070013;GO:0005759;GO:0005886;GO:1903561;GO:0005575;GO:0005576; membrane-enclosed lumen;envelope;vesicle;nuclear lumen;myelin sheath;membrane;organelle envelope;mitochondrial membrane;extracellular organelle;organelle lumen;intracellular membrane-bounded organelle;nuclear part;mitochondrial part;intracellular part;extracellular region part;organelle part;organelle inner membrane;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;nucleus;mitochondrion;cell part;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;cell periphery;extracellular exosome;intracellular organelle lumen;mitochondrial matrix;plasma membrane;extracellular vesicle;cellular_component;extracellular region; 2;3;4;5;3;2;4;4;3;3;4;4;4;3;2;2;4;3;3;2;5;3;4;4;3;5;5;2;2;3;5;5;3;4;4;5;3;3;1;2; GO:1901363;GO:0016615;GO:0016616;GO:0046554;GO:0003674;GO:0003676;GO:0003824;GO:0097159;GO:0030060;GO:0016491;GO:0044822;GO:0003723;GO:0005488;GO:0016614; heterocyclic compound binding;malate dehydrogenase activity;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;malate dehydrogenase (NADP+) activity;molecular_function;nucleic acid binding;catalytic activity;organic cyclic compound binding;L-malate dehydrogenase activity;oxidoreductase activity;poly(A) RNA binding;RNA binding;binding;oxidoreductase activity, acting on CH-OH group of donors; 3;5;5;6;1;4;2;3;6;3;6;5;2;4; K00026 map00020;map00270;map00620;map00630;map00710;map01100;map01110;map01120;map01130;map01200; Citrate cycle (TCA cycle);Cysteine and methionine metabolism;Pyruvate metabolism;Glyoxylate and dicarboxylate metabolism;Carbon fixation in photosynthetic organisms;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism; IPR001236;IPR001252;IPR015955;IPR001557;IPR022383;IPR010097;IPR016040; Lactate/malate dehydrogenase, N-terminal;Malate dehydrogenase, active site;Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal;L-lactate/malate dehydrogenase;Lactate/malate dehydrogenase, C-terminal;Malate dehydrogenase, type 1;NAD(P)-binding domain; mitochondria Hs21735621 686.0 C [C] Energy production and conversion; Q96GV9 UNC119-binding protein C5orf30 OS=Homo sapiens OX=9606 GN=C5orf30 PE=1 SV=1 - [CE030_HUMAN] 0.615 0.617 2.408 0.752 0.619 0.502 0.996758509 nan 1.214862682 nan 3.902755267 nan 0.81098546 nan GO:0008104;GO:0051234;GO:0030030;GO:0032989;GO:0044699;GO:0000902;GO:0009653;GO:0048869;GO:0048858;GO:0016043;GO:0071840;GO:0071702;GO:0033036;GO:0032502;GO:0009987;GO:0060271;GO:0006810;GO:0045184;GO:0008150;GO:0051179;GO:0048856;GO:0032990;GO:0044767;GO:0015031;GO:0044763; protein localization;establishment of localization;cell projection organization;cellular component morphogenesis;single-organism process;cell morphogenesis;anatomical structure morphogenesis;cellular developmental process;cell projection morphogenesis;cellular component organization;cellular component organization or biogenesis;organic substance transport;macromolecule localization;developmental process;cellular process;cilium morphogenesis;transport;establishment of protein localization;biological_process;localization;anatomical structure development;cell part morphogenesis;single-organism developmental process;protein transport;single-organism cellular process; 4;3;4;4;2;5;3;4;5;3;2;5;3;2;2;6;4;4;1;2;3;5;3;5;3; GO:0005929;GO:0043226;GO:0005737;GO:0072372;GO:0031513;GO:0044424;GO:0042995;GO:0035869;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044441;GO:0044422; cilium;organelle;cytoplasm;primary cilium;nonmotile primary cilium;intracellular part;cell projection;ciliary transition zone;cell projection part;cell part;cell;intracellular;cellular_component;ciliary part;organelle part; 3;2;4;4;5;3;3;4;3;2;2;3;1;3;2; IPR029219; UNC119-binding protein; nucleus P01704 Immunoglobulin lambda variable 2-14 OS=Homo sapiens OX=9606 GN=IGLV2-14 PE=1 SV=2 - [LV214_HUMAN] 1.832 0.631 0.944 1.563 0.479 1.008 2.903328051 0.018504249 3.263048017 0.047752884 1.496038035 0.347475676 2.104384134 0.59980243 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q9NYQ8 Protocadherin Fat 2 OS=Homo sapiens OX=9606 GN=FAT2 PE=1 SV=2 - [FAT2_HUMAN] 1.023 0.89 1.286 1.092 0.894 0.822 1.149438202 0.378718644 1.22147651 0.06395739 1.44494382 0.086084324 0.919463087 0.23165018 GO:0090132;GO:0006928;GO:0016477;GO:0001667;GO:0010631;GO:0007156;GO:0051674;GO:0008150;GO:0090130;GO:0032501;GO:0098609;GO:0007155;GO:0051179;GO:0098742;GO:0040011;GO:0044699;GO:0022610;GO:0044707;GO:0048870;GO:0044763;GO:0009987; epithelium migration;movement of cell or subcellular component;cell migration;ameboidal-type cell migration;epithelial cell migration;homophilic cell adhesion via plasma membrane adhesion molecules;localization of cell;biological_process;tissue migration;multicellular organismal process;cell-cell adhesion;cell adhesion;localization;cell-cell adhesion via plasma-membrane adhesion molecules;locomotion;single-organism process;biological adhesion;single-multicellular organism process;cell motility;single-organism cellular process;cellular process; 5;4;4;5;6;6;3;1;4;2;4;3;2;5;2;2;2;3;3;3;2; GO:0031224;GO:0071944;GO:0005634;GO:0043227;GO:0043226;GO:0030054;GO:0070062;GO:0016021;GO:0016020;GO:0070161;GO:0005913;GO:0005912;GO:0005911;GO:0005886;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044425;GO:0044421; intrinsic component of membrane;cell periphery;nucleus;membrane-bounded organelle;organelle;cell junction;extracellular exosome;integral component of membrane;membrane;anchoring junction;cell-cell adherens junction;adherens junction;cell-cell junction;plasma membrane;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;extracellular region;intracellular part;membrane part;extracellular region part; 3;3;5;3;2;2;4;4;2;3;4;4;3;3;3;4;3;4;2;3;2;3;1;2;3;2;2; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding; 1;2;4;3;6;5; K16506 IPR002126;IPR020894;IPR000742;IPR001881;IPR013032;IPR015919;IPR001791;IPR013320; Cadherin;Cadherin conserved site;EGF-like domain;EGF-like calcium-binding domain;EGF-like, conserved site;Cadherin-like;Laminin G domain;Concanavalin A-like lectin/glucanase domain; plasma membrane Hs13787217 9004.0 T [T] Signal transduction mechanisms; P02768 Serum albumin OS=Homo sapiens OX=9606 GN=ALB PE=1 SV=2 - [ALBU_HUMAN] 1.054 1.403 0.65 0.924 1.271 0.66 0.751247327 nan 0.726986625 nan 0.463292944 nan 0.519276161 3.98E-17 GO:0007599;GO:0060249;GO:0015721;GO:0007596;GO:0048583;GO:0006820;GO:0051659;GO:0060548;GO:0032940;GO:0051657;GO:0051651;GO:1901360;GO:0009267;GO:0051715;GO:0044710;GO:0045188;GO:0009611;GO:0044419;GO:0048511;GO:0048512;GO:0051817;GO:0048518;GO:0048519;GO:0001906;GO:0001907;GO:0050795;GO:0048584;GO:0015718;GO:0015849;GO:0046689;GO:0015711;GO:0032787;GO:1990748;GO:0045187;GO:0007610;GO:0010038;GO:0043436;GO:0051701;GO:0010035;GO:0010876;GO:0010033;GO:0030168;GO:0051704;GO:0031668;GO:0031669;GO:0044707;GO:0019538;GO:0044708;GO:0031667;GO:1901615;GO:0007154;GO:0033554;GO:0070541;GO:0048520;GO:0044281;GO:0033036;GO:0015850;GO:0042749;GO:0042748;GO:0019835;GO:0019836;GO:0006887;GO:0048871;GO:0045055;GO:0006629;GO:0065007;GO:0065008;GO:0007623;GO:0007622;GO:0046010;GO:0006811;GO:0006810;GO:0051716;GO:0042060;GO:0050794;GO:0051818;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0051235;GO:0051234;GO:0043252;GO:0046903;GO:0006897;GO:0012501;GO:0050896;GO:0006898;GO:0031640;GO:0001775;GO:0098869;GO:0044003;GO:0051240;GO:0051239;GO:0006869;GO:0050802;GO:0008206;GO:0001894;GO:0044699;GO:0042753;GO:0044364;GO:1902578;GO:0030431;GO:0046942;GO:0032501;GO:0050878;GO:0009987;GO:0001897;GO:0052331;GO:0001895;GO:0055085;GO:0008202;GO:0006082;GO:0042745;GO:0043170;GO:0042157;GO:0009991;GO:1990267;GO:0098754;GO:0019752;GO:0042592;GO:0071496;GO:0042594;GO:0008219;GO:0010941;GO:0042981;GO:0002576;GO:0044179;GO:0009636;GO:0050789;GO:0071704;GO:0043067;GO:0043066;GO:0071702;GO:0043069;GO:0009605;GO:0045938;GO:0007584;GO:0006915;GO:0044765;GO:0044764;GO:0044763;GO:0022410;GO:0051646;GO:0042221;GO:0044004;GO:0051179;GO:0051640;GO:0051641;GO:0044238;GO:0051883;GO:0042752;GO:0044237;GO:0051801;GO:0044403;GO:1902580;GO:0035821;GO:0048523;GO:0016192; hemostasis;anatomical structure homeostasis;bile acid and bile salt transport;blood coagulation;regulation of response to stimulus;anion transport;maintenance of mitochondrion location;negative regulation of cell death;secretion by cell;maintenance of organelle location;maintenance of location in cell;organic cyclic compound metabolic process;cellular response to starvation;cytolysis in other organism;single-organism metabolic process;regulation of circadian sleep/wake cycle, non-REM sleep;response to wounding;interspecies interaction between organisms;rhythmic process;circadian behavior;modification of morphology or physiology of other organism involved in symbiotic interaction;positive regulation of biological process;negative regulation of biological process;cell killing;killing by symbiont of host cells;regulation of behavior;positive regulation of response to stimulus;monocarboxylic acid transport;organic acid transport;response to mercury ion;organic anion transport;monocarboxylic acid metabolic process;cellular detoxification;regulation of circadian sleep/wake cycle, sleep;behavior;response to metal ion;oxoacid metabolic process;interaction with host;response to inorganic substance;lipid localization;response to organic substance;platelet activation;multi-organism process;cellular response to extracellular stimulus;cellular response to nutrient levels;single-multicellular organism process;protein metabolic process;single-organism behavior;response to nutrient levels;organic hydroxy compound metabolic process;cell communication;cellular response to stress;response to platinum ion;positive regulation of behavior;small molecule metabolic process;macromolecule localization;organic hydroxy compound transport;regulation of circadian sleep/wake cycle;circadian sleep/wake cycle, non-REM sleep;cytolysis;hemolysis by symbiont of host erythrocytes;exocytosis;multicellular organismal homeostasis;regulated exocytosis;lipid metabolic process;biological regulation;regulation of biological quality;circadian rhythm;rhythmic behavior;positive regulation of circadian sleep/wake cycle, non-REM sleep;ion transport;transport;cellular response to stimulus;wound healing;regulation of cellular process;disruption of cells of other organism involved in symbiotic interaction;response to stress;coagulation;biological_process;metabolic process;maintenance of location;establishment of localization;sodium-independent organic anion transport;secretion;endocytosis;programmed cell death;response to stimulus;receptor-mediated endocytosis;killing of cells of other organism;cell activation;cellular oxidant detoxification;modification by symbiont of host morphology or physiology;positive regulation of multicellular organismal process;regulation of multicellular organismal process;lipid transport;circadian sleep/wake cycle, sleep;bile acid metabolic process;tissue homeostasis;single-organism process;positive regulation of circadian rhythm;disruption of cells of other organism;single-organism localization;sleep;carboxylic acid transport;multicellular organismal process;regulation of body fluid levels;cellular process;cytolysis by symbiont of host cells;hemolysis in other organism involved in symbiotic interaction;retina homeostasis;transmembrane transport;steroid metabolic process;organic acid metabolic process;circadian sleep/wake cycle;macromolecule metabolic process;lipoprotein metabolic process;response to extracellular stimulus;response to transition metal nanoparticle;detoxification;carboxylic acid metabolic process;homeostatic process;cellular response to external stimulus;response to starvation;cell death;regulation of cell death;regulation of apoptotic process;platelet degranulation;hemolysis in other organism;response to toxic substance;regulation of biological process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;organic substance transport;negative regulation of programmed cell death;response to external stimulus;positive regulation of circadian sleep/wake cycle, sleep;response to nutrient;apoptotic process;single-organism transport;multi-organism cellular process;single-organism cellular process;circadian sleep/wake cycle process;mitochondrion localization;response to chemical;disruption by symbiont of host cell;localization;organelle localization;cellular localization;primary metabolic process;killing of cells in other organism involved in symbiotic interaction;regulation of circadian rhythm;cellular metabolic process;cytolysis in other organism involved in symbiotic interaction;symbiosis, encompassing mutualism through parasitism;single-organism cellular localization;modification of morphology or physiology of other organism;negative regulation of cellular process;vesicle-mediated transport; 5;5;6;5;3;6;5;4;4;5;4;4;5;4;3;6;4;3;2;4;4;2;2;2;5;3;3;7;5;5;6;7;3;5;2;5;5;4;4;4;4;5;2;4;5;3;4;3;5;4;4;4;6;3;4;3;5;4;5;3;6;5;4;6;4;2;3;3;3;5;5;4;3;5;3;5;3;4;1;2;3;3;7;5;6;5;2;7;3;4;4;5;3;3;5;4;5;5;2;3;4;3;4;6;2;4;2;6;5;6;4;5;4;5;4;5;4;4;2;6;4;4;4;4;4;6;7;5;4;2;3;5;6;5;5;3;4;4;6;4;3;3;5;5;3;6;2;4;3;3;4;3;3;5;4;4;3;3;5; GO:0031974;GO:0005783;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0005794;GO:0099503;GO:0034774;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044420;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0072562;GO:0044433;GO:0030141;GO:0012505;GO:0044446;GO:0043209;GO:0044444;GO:0097708;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0005634;GO:0070062;GO:0005578;GO:0044464;GO:0005623;GO:0005615;GO:1903561;GO:0005604;GO:0032991;GO:0005575;GO:0031012;GO:0005576; membrane-enclosed lumen;endoplasmic reticulum;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;Golgi apparatus;secretory vesicle;secretory granule lumen;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular matrix component;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;blood microparticle;cytoplasmic vesicle part;secretory granule;endomembrane system;intracellular organelle part;myelin sheath;cytoplasmic part;intracellular vesicle;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;nucleus;extracellular exosome;proteinaceous extracellular matrix;cell part;cell;extracellular space;extracellular vesicle;basement membrane;macromolecular complex;cellular_component;extracellular matrix;extracellular region; 2;4;4;4;5;5;4;6;5;3;3;4;3;3;2;2;2;3;3;3;2;3;4;4;3;3;3;4;4;5;4;5;6;5;5;4;3;2;2;3;3;3;2;1;2;2; GO:0030170;GO:0015643;GO:0008270;GO:1901363;GO:0016209;GO:0005507;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0046914;GO:0043168;GO:0097159;GO:0008144;GO:0043169;GO:0051087;GO:0043167;GO:0005504;GO:0042802;GO:0008289;GO:0048037;GO:0046872;GO:0043177;GO:0005515;GO:0031406;GO:0036094;GO:0033293; pyridoxal phosphate binding;toxic substance binding;zinc ion binding;heterocyclic compound binding;antioxidant activity;copper ion binding;molecular_function;binding;nucleic acid binding;DNA binding;transition metal ion binding;anion binding;organic cyclic compound binding;drug binding;cation binding;chaperone binding;ion binding;fatty acid binding;identical protein binding;lipid binding;cofactor binding;metal ion binding;organic acid binding;protein binding;carboxylic acid binding;small molecule binding;monocarboxylic acid binding; 4;3;7;3;2;7;1;2;4;5;6;4;3;3;4;4;3;4;4;3;3;5;4;3;5;3;6; K16141 IPR021177;IPR000264;IPR020858;IPR020857;IPR014760; Serum albumin/Alpha-fetoprotein/Afamin;ALB/AFP/VDB;Serum albumin-like;Serum albumin, conserved site;Serum albumin, N-terminal; extracellular P04259 Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5 - [K2C6B_HUMAN] 1.035 1.105 0.911 1.145 0.994 1.172 0.936651584 nan 1.151911469 nan 0.824434389 nan 1.179074447 nan GO:0032502;GO:0009888;GO:0008150;GO:0007398;GO:0048856; developmental process;tissue development;biological_process;ectoderm development;anatomical structure development; 2;4;1;5;3; GO:0099512;GO:0099513;GO:0045095;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0005575;GO:0045111;GO:0070062;GO:0044430;GO:0005882;GO:1903561;GO:0031982;GO:0043230;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0005576;GO:0044424;GO:0044421;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;keratin filament;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cellular_component;intermediate filament cytoskeleton;extracellular exosome;cytoskeletal part;intermediate filament;extracellular vesicle;vesicle;extracellular organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;5;3;3;3;2;5;1;6;4;4;4;3;4;3;4;2;2;3;3;2;3;2;2; GO:0005200;GO:0003674;GO:0005198; structural constituent of cytoskeleton;molecular_function;structural molecule activity; 3;1;2; K07605 IPR003054;IPR001664;IPR032444;IPR018039; Keratin, type II;Intermediate filament protein;Keratin type II head;Intermediate filament protein, conserved site; nucleus 384209928 56.2 L [L] Replication, recombination and repair; COG0419 DNA repair exonuclease SbcCD ATPase subunit P20936 Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1 - [RASA1_HUMAN] 0.694 0.751 1.738 1.11 0.673 0.503 0.924101198 0.868880235 1.649331352 0.411112112 2.31424767 0.27979361 0.747399703 nan GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0032147;GO:0008064;GO:0072359;GO:0043523;GO:0043524;GO:0007165;GO:0007166;GO:0007167;GO:0030182;GO:0007169;GO:0023014;GO:0051716;GO:0010604;GO:0042330;GO:0009966;GO:0009967;GO:0071840;GO:0070271;GO:0000165;GO:0070848;GO:0051493;GO:0048514;GO:0044093;GO:0048518;GO:0048519;GO:0000910;GO:0031589;GO:0038179;GO:0006935;GO:0060255;GO:0060548;GO:0045859;GO:0006952;GO:0051058;GO:0042221;GO:0008360;GO:0007173;GO:0030041;GO:0043434;GO:0097485;GO:0010033;GO:0046483;GO:0042325;GO:0044700;GO:0042327;GO:0009605;GO:0044707;GO:0023057;GO:0019538;GO:0010243;GO:0034641;GO:0071310;GO:0002376;GO:0072358;GO:0002768;GO:0032535;GO:0010648;GO:0022604;GO:0022607;GO:0009893;GO:0033674;GO:0006928;GO:0010812;GO:0001953;GO:0006807;GO:0031175;GO:0030029;GO:0035556;GO:0071900;GO:0042981;GO:0050789;GO:0044267;GO:0009653;GO:0051347;GO:0000902;GO:0044260;GO:0070997;GO:0001568;GO:0043549;GO:0006955;GO:0044344;GO:0016043;GO:0090066;GO:0065003;GO:0010810;GO:0065007;GO:0044699;GO:0065009;GO:0065008;GO:0006461;GO:0061564;GO:0050793;GO:0050790;GO:0044710;GO:0048468;GO:0050794;GO:0043410;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:1901700;GO:0008152;GO:0032956;GO:1902532;GO:1902533;GO:1901214;GO:1902531;GO:0016070;GO:0044767;GO:0038095;GO:0009968;GO:1903047;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0032970;GO:0048812;GO:0050776;GO:0007160;GO:0048869;GO:0071774;GO:0051171;GO:0033043;GO:0016310;GO:0030155;GO:0030154;GO:0046578;GO:0051128;GO:0023056;GO:0009790;GO:0043405;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0007411;GO:0010647;GO:0010646;GO:0008543;GO:0007265;GO:0043085;GO:0043408;GO:0009719;GO:0006139;GO:1901215;GO:0071375;GO:1901360;GO:0043623;GO:0010562;GO:0022603;GO:0051246;GO:0051247;GO:0043933;GO:0007162;GO:0032270;GO:0032271;GO:0031399;GO:0022610;GO:0048011;GO:0032502;GO:0006996;GO:0008286;GO:0032501;GO:0007015;GO:0009987;GO:0006725;GO:0032870;GO:1901701;GO:0000281;GO:0007409;GO:0048010;GO:0048858;GO:0051258;GO:0007049;GO:0032268;GO:0071363;GO:0009725;GO:0051252;GO:0001952;GO:0043170;GO:0048013;GO:0048731;GO:0045860;GO:1901698;GO:0061640;GO:0000186;GO:0002682;GO:1901699;GO:0001944;GO:0030030;GO:0031325;GO:0031323;GO:0030036;GO:0090304;GO:0022402;GO:0034622;GO:0032869;GO:0032868;GO:0008219;GO:0010941;GO:0007275;GO:0051301;GO:0030833;GO:0038093;GO:0071822;GO:0071417;GO:1902589;GO:0032989;GO:0071704;GO:0043067;GO:0043066;GO:0043069;GO:0048666;GO:0048667;GO:0006468;GO:0000278;GO:0045937;GO:0019219;GO:0045087;GO:0006915;GO:0001570;GO:0030832;GO:0006464;GO:0051174;GO:0051402;GO:0000904;GO:0044763;GO:0046580;GO:0007155;GO:0007154;GO:0022008;GO:0007264;GO:0008154;GO:0043254;GO:0002764;GO:0040011;GO:0044238;GO:0048699;GO:0007010;GO:0032990;GO:0007399;GO:0048856;GO:0044237;GO:0071495;GO:0044087;GO:0006796;GO:0044085;GO:1901652;GO:1901653;GO:0051056;GO:0006793;GO:0001932;GO:0001934;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;regulation of actin polymerization or depolymerization;circulatory system development;regulation of neuron apoptotic process;negative regulation of neuron apoptotic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;neuron differentiation;transmembrane receptor protein tyrosine kinase signaling pathway;signal transduction by protein phosphorylation;cellular response to stimulus;positive regulation of macromolecule metabolic process;taxis;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;protein complex biogenesis;MAPK cascade;response to growth factor;regulation of cytoskeleton organization;blood vessel morphogenesis;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;cytokinesis;cell-substrate adhesion;neurotrophin signaling pathway;chemotaxis;regulation of macromolecule metabolic process;negative regulation of cell death;regulation of protein kinase activity;defense response;negative regulation of small GTPase mediated signal transduction;response to chemical;regulation of cell shape;epidermal growth factor receptor signaling pathway;actin filament polymerization;response to peptide hormone;neuron projection guidance;response to organic substance;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;response to external stimulus;single-multicellular organism process;negative regulation of signaling;protein metabolic process;response to organonitrogen compound;cellular nitrogen compound metabolic process;cellular response to organic substance;immune system process;cardiovascular system development;immune response-regulating cell surface receptor signaling pathway;regulation of cellular component size;negative regulation of cell communication;regulation of cell morphogenesis;cellular component assembly;positive regulation of metabolic process;positive regulation of kinase activity;movement of cell or subcellular component;negative regulation of cell-substrate adhesion;negative regulation of cell-matrix adhesion;nitrogen compound metabolic process;neuron projection development;actin filament-based process;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of apoptotic process;regulation of biological process;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cell morphogenesis;cellular macromolecule metabolic process;neuron death;blood vessel development;regulation of kinase activity;immune response;cellular response to fibroblast growth factor stimulus;cellular component organization;regulation of anatomical structure size;macromolecular complex assembly;regulation of cell-substrate adhesion;biological regulation;single-organism process;regulation of molecular function;regulation of biological quality;protein complex assembly;axon development;regulation of developmental process;regulation of catalytic activity;single-organism metabolic process;cell development;regulation of cellular process;positive regulation of MAPK cascade;programmed cell death;macromolecule modification;protein modification process;biological_process;response to oxygen-containing compound;metabolic process;regulation of actin cytoskeleton organization;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;regulation of neuron death;regulation of intracellular signal transduction;RNA metabolic process;single-organism developmental process;Fc-epsilon receptor signaling pathway;negative regulation of signal transduction;mitotic cell cycle process;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;regulation of actin filament-based process;neuron projection morphogenesis;regulation of immune response;cell-matrix adhesion;cellular developmental process;response to fibroblast growth factor;regulation of nitrogen compound metabolic process;regulation of organelle organization;phosphorylation;regulation of cell adhesion;cell differentiation;regulation of Ras protein signal transduction;regulation of cellular component organization;positive regulation of signaling;embryo development;regulation of MAP kinase activity;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;axon guidance;positive regulation of cell communication;regulation of cell communication;fibroblast growth factor receptor signaling pathway;Ras protein signal transduction;positive regulation of catalytic activity;regulation of MAPK cascade;response to endogenous stimulus;nucleobase-containing compound metabolic process;negative regulation of neuron death;cellular response to peptide hormone stimulus;organic cyclic compound metabolic process;cellular protein complex assembly;positive regulation of phosphorus metabolic process;regulation of anatomical structure morphogenesis;regulation of protein metabolic process;positive regulation of protein metabolic process;macromolecular complex subunit organization;negative regulation of cell adhesion;positive regulation of cellular protein metabolic process;regulation of protein polymerization;regulation of protein modification process;biological adhesion;neurotrophin TRK receptor signaling pathway;developmental process;organelle organization;insulin receptor signaling pathway;multicellular organismal process;actin filament organization;cellular process;cellular aromatic compound metabolic process;cellular response to hormone stimulus;cellular response to oxygen-containing compound;mitotic cytokinesis;axonogenesis;vascular endothelial growth factor receptor signaling pathway;cell projection morphogenesis;protein polymerization;cell cycle;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;response to hormone;regulation of RNA metabolic process;regulation of cell-matrix adhesion;macromolecule metabolic process;ephrin receptor signaling pathway;system development;positive regulation of protein kinase activity;response to nitrogen compound;cytoskeleton-dependent cytokinesis;activation of MAPKK activity;regulation of immune system process;cellular response to nitrogen compound;vasculature development;cell projection organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;actin cytoskeleton organization;nucleic acid metabolic process;cell cycle process;cellular macromolecular complex assembly;cellular response to insulin stimulus;response to insulin;cell death;regulation of cell death;multicellular organism development;cell division;regulation of actin filament polymerization;Fc receptor signaling pathway;protein complex subunit organization;cellular response to organonitrogen compound;single-organism organelle organization;cellular component morphogenesis;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;mitotic cell cycle;positive regulation of phosphate metabolic process;regulation of nucleobase-containing compound metabolic process;innate immune response;apoptotic process;vasculogenesis;regulation of actin filament length;cellular protein modification process;regulation of phosphorus metabolic process;neuron apoptotic process;cell morphogenesis involved in differentiation;single-organism cellular process;negative regulation of Ras protein signal transduction;cell adhesion;cell communication;neurogenesis;small GTPase mediated signal transduction;actin polymerization or depolymerization;regulation of protein complex assembly;immune response-regulating signaling pathway;locomotion;primary metabolic process;generation of neurons;cytoskeleton organization;cell part morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;cellular response to endogenous stimulus;regulation of cellular component biogenesis;phosphate-containing compound metabolic process;cellular component biogenesis;response to peptide;cellular response to peptide;regulation of small GTPase mediated signal transduction;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;3;3;3;9;6;5;6;6;4;5;6;6;7;4;3;4;3;4;4;2;4;5;5;6;4;4;2;2;5;4;6;4;4;4;7;4;6;3;4;9;8;5;5;4;4;7;3;7;3;3;3;4;4;4;5;2;5;6;4;4;5;4;3;7;4;5;6;3;5;4;5;8;6;2;5;3;6;5;4;5;4;6;3;5;3;4;5;5;2;2;3;3;5;6;3;4;3;4;3;6;5;5;5;1;4;2;5;5;5;5;5;5;3;8;4;5;2;6;3;5;4;6;4;5;4;4;4;5;6;4;5;7;4;3;5;7;2;8;4;3;6;4;4;6;7;5;6;3;4;5;6;4;6;5;4;5;5;4;4;5;5;6;2;7;2;4;8;2;6;2;4;5;5;6;7;8;5;7;4;5;6;4;5;6;4;8;4;8;4;6;7;3;5;5;4;4;4;5;5;4;6;7;6;4;4;4;4;6;7;5;5;4;4;3;5;6;5;5;6;7;5;6;5;4;6;5;5;6;5;6;5;3;7;3;4;6;6;7;4;5;2;3;7;5;5;5;3;3;4;3;5;3;5;6;6;4;7;7;3;3; GO:0044444;GO:0042995;GO:0044424;GO:0044425;GO:0005829;GO:0098562;GO:0009898;GO:0031226;GO:0005737;GO:0044459;GO:0031224;GO:0016020;GO:0031235;GO:0031252;GO:0044464;GO:0005623;GO:0098552;GO:0071944;GO:0005575;GO:0001726;GO:0005622;GO:0005886; cytoplasmic part;cell projection;intracellular part;membrane part;cytosol;cytoplasmic side of membrane;cytoplasmic side of plasma membrane;intrinsic component of plasma membrane;cytoplasm;plasma membrane part;intrinsic component of membrane;membrane;intrinsic component of the cytoplasmic side of the plasma membrane;cell leading edge;cell part;cell;side of membrane;cell periphery;cellular_component;ruffle;intracellular;plasma membrane; 4;3;3;2;5;4;4;4;4;3;3;2;5;3;2;2;3;3;1;4;3;3; GO:0060589;GO:0098772;GO:0001948;GO:0030695;GO:0097367;GO:0051020;GO:0003674;GO:0005488;GO:0030234;GO:0019899;GO:0015459;GO:0008200;GO:0005515;GO:0005102;GO:0008047;GO:0019870;GO:0016248;GO:0016247;GO:0005096; nucleoside-triphosphatase regulator activity;molecular function regulator;glycoprotein binding;GTPase regulator activity;carbohydrate derivative binding;GTPase binding;molecular_function;binding;enzyme regulator activity;enzyme binding;potassium channel regulator activity;ion channel inhibitor activity;protein binding;receptor binding;enzyme activator activity;potassium channel inhibitor activity;channel inhibitor activity;channel regulator activity;GTPase activator activity; 4;2;4;5;3;5;1;2;3;4;4;5;3;4;4;5;4;3;5; K04352 map04010;map04014;map04360; MAPK signaling pathway;Ras signaling pathway;Axon guidance; IPR008936;IPR001936;IPR035652;IPR000980;IPR001452;IPR023152;IPR001849;IPR011993;IPR000008;IPR028554; Rho GTPase activation protein;Ras GTPase-activating protein;RasGAP, SH3 domain;SH2 domain;SH3 domain;Ras GTPase-activating protein, conserved site;Pleckstrin homology domain;PH domain-like;C2 domain;Ras GTPase-activating protein 1; cytosol Hs4506431 2175.0 R [R] General function prediction only; Q8IYX1 TBC1 domain family member 21 OS=Homo sapiens OX=9606 GN=TBC1D21 PE=1 SV=1 - [TBC21_HUMAN] 1.149 1.214 0.729 1.235 0.873 1.235 0.94645799 0.71735241 1.414662085 0.036356573 0.600494234 0.099317904 1.414662085 0.02763919 GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0031982;GO:0016023;GO:0031410;GO:0097223;GO:0031988;GO:0099503;GO:0030141;GO:0012505;GO:1903561;GO:0070062;GO:0043230;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0001669;GO:0044421;GO:0097708; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;sperm part;membrane-bounded vesicle;secretory vesicle;secretory granule;endomembrane system;extracellular vesicle;extracellular exosome;extracellular organelle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;acrosomal vesicle;extracellular region part;intracellular vesicle; 3;3;2;4;4;5;5;3;5;6;4;3;3;4;3;4;2;2;3;1;4;2;3;4;2;4; GO:0003674;GO:0008047;GO:0098772;GO:0030234;GO:0005096;GO:0030695;GO:0060589; molecular_function;enzyme activator activity;molecular function regulator;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity; 1;4;2;3;5;5;4; IPR000195; Rab-GTPase-TBC domain; mitochondria Hs22055332 701.0 T [T] Signal transduction mechanisms; P02760 Protein AMBP OS=Homo sapiens OX=9606 GN=AMBP PE=1 SV=1 - [AMBP_HUMAN] 1.059 1.058 0.875 1.075 1.053 0.963 1.00094518 0.72178394 1.020892688 0.006181143 0.827032136 1.88E-09 0.914529915 0.000284091 GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0006778;GO:0007165;GO:0023014;GO:1901361;GO:0044712;GO:0044710;GO:0010605;GO:0009968;GO:0009966;GO:0000165;GO:0044419;GO:0048519;GO:0051704;GO:0002683;GO:0060255;GO:0050777;GO:0050776;GO:0030163;GO:1901564;GO:0046483;GO:0042325;GO:0044700;GO:0044703;GO:0042326;GO:1901565;GO:0044706;GO:0019538;GO:0007254;GO:0002376;GO:0033554;GO:0019439;GO:0009892;GO:0006787;GO:0080134;GO:0006807;GO:0046329;GO:0046328;GO:0035556;GO:0050789;GO:0046700;GO:0044267;GO:1901575;GO:0051186;GO:0044260;GO:0033015;GO:0065007;GO:0043409;GO:0006810;GO:0051716;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0018298;GO:0008152;GO:0006955;GO:1902532;GO:0042440;GO:1902531;GO:0046149;GO:0000003;GO:0006897;GO:0050896;GO:0080135;GO:0006950;GO:0044764;GO:0016310;GO:0044248;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0044699;GO:0043408;GO:0051248;GO:0051234;GO:0010563;GO:0051246;GO:0031098;GO:0051179;GO:0031399;GO:0022610;GO:0042168;GO:0070302;GO:0070303;GO:0009987;GO:0006725;GO:0032872;GO:0032873;GO:0044270;GO:0033013;GO:0032269;GO:0032268;GO:0007565;GO:0043170;GO:0031400;GO:0006898;GO:0031324;GO:0031323;GO:0002682;GO:1901360;GO:0071704;GO:0032501;GO:0006468;GO:0045936;GO:0042167;GO:0051187;GO:0006464;GO:0051174;GO:0022414;GO:0051403;GO:0044763;GO:0007155;GO:0007154;GO:0009056;GO:0009057;GO:0044238;GO:0044237;GO:0006796;GO:0016032;GO:0006793;GO:0044403;GO:0001933;GO:0001932;GO:0048523;GO:0016192; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;porphyrin-containing compound metabolic process;signal transduction;signal transduction by protein phosphorylation;organic cyclic compound catabolic process;single-organism catabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;MAPK cascade;interspecies interaction between organisms;negative regulation of biological process;multi-organism process;negative regulation of immune system process;regulation of macromolecule metabolic process;negative regulation of immune response;regulation of immune response;protein catabolic process;organonitrogen compound metabolic process;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;multi-organism reproductive process;negative regulation of phosphorylation;organonitrogen compound catabolic process;multi-multicellular organism process;protein metabolic process;JNK cascade;immune system process;cellular response to stress;aromatic compound catabolic process;negative regulation of metabolic process;porphyrin-containing compound catabolic process;regulation of response to stress;nitrogen compound metabolic process;negative regulation of JNK cascade;regulation of JNK cascade;intracellular signal transduction;regulation of biological process;heterocycle catabolic process;cellular protein metabolic process;organic substance catabolic process;cofactor metabolic process;cellular macromolecule metabolic process;tetrapyrrole catabolic process;biological regulation;negative regulation of MAPK cascade;transport;cellular response to stimulus;regulation of cellular process;macromolecule modification;protein modification process;biological_process;protein-chromophore linkage;metabolic process;immune response;negative regulation of intracellular signal transduction;pigment metabolic process;regulation of intracellular signal transduction;pigment catabolic process;reproduction;endocytosis;response to stimulus;regulation of cellular response to stress;response to stress;multi-organism cellular process;phosphorylation;cellular catabolic process;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;single-organism process;regulation of MAPK cascade;negative regulation of protein metabolic process;establishment of localization;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;localization;regulation of protein modification process;biological adhesion;heme metabolic process;regulation of stress-activated protein kinase signaling cascade;negative regulation of stress-activated protein kinase signaling cascade;cellular process;cellular aromatic compound metabolic process;regulation of stress-activated MAPK cascade;negative regulation of stress-activated MAPK cascade;cellular nitrogen compound catabolic process;tetrapyrrole metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;female pregnancy;macromolecule metabolic process;negative regulation of protein modification process;receptor-mediated endocytosis;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of immune system process;organic cyclic compound metabolic process;organic substance metabolic process;multicellular organismal process;protein phosphorylation;negative regulation of phosphate metabolic process;heme catabolic process;cofactor catabolic process;cellular protein modification process;regulation of phosphorus metabolic process;reproductive process;stress-activated MAPK cascade;single-organism cellular process;cell adhesion;cell communication;catabolic process;macromolecule catabolic process;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;viral process;phosphorus metabolic process;symbiosis, encompassing mutualism through parasitism;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process;vesicle-mediated transport; 6;4;3;3;3;5;4;4;5;4;3;4;4;4;5;3;2;2;3;4;4;4;5;4;4;7;3;3;7;5;3;4;7;2;4;5;3;6;4;3;8;7;5;2;5;5;4;4;4;6;2;6;4;3;3;5;5;1;7;2;3;5;4;5;5;2;6;2;4;3;3;6;4;3;4;2;4;3;4;2;6;5;3;5;5;5;2;6;2;4;5;6;2;4;6;7;5;5;5;5;4;4;6;7;4;4;3;4;3;2;7;6;5;5;6;5;2;6;3;3;4;3;5;3;3;5;4;4;4;7;7;3;5; GO:0031982;GO:0016020;GO:0043230;GO:0043231;GO:0044421;GO:0043229;GO:0005622;GO:0043227;GO:0072562;GO:0044424;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;intracellular membrane-bounded organelle;extracellular region part;intracellular organelle;intracellular;membrane-bounded organelle;blood microparticle;intracellular part;cell surface;cell part;cell;cell periphery;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;cellular_component;extracellular region; 4;2;3;4;2;3;3;3;3;3;3;2;2;3;3;2;3;3;4;1;2; GO:0030414;GO:0098772;GO:1901363;GO:0046904;GO:0003674;GO:0005488;GO:0061135;GO:0020037;GO:0036094;GO:0019855;GO:0046906;GO:0097159;GO:0005246;GO:0046983;GO:0004857;GO:0032403;GO:0042802;GO:0042803;GO:0004866;GO:0004867;GO:0008200;GO:0019862;GO:0005515;GO:0044877;GO:0016248;GO:0016247;GO:0030234;GO:0061134;GO:0019865; peptidase inhibitor activity;molecular function regulator;heterocyclic compound binding;calcium oxalate binding;molecular_function;binding;endopeptidase regulator activity;heme binding;small molecule binding;calcium channel inhibitor activity;tetrapyrrole binding;organic cyclic compound binding;calcium channel regulator activity;protein dimerization activity;enzyme inhibitor activity;protein complex binding;identical protein binding;protein homodimerization activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;ion channel inhibitor activity;IgA binding;protein binding;macromolecular complex binding;channel inhibitor activity;channel regulator activity;enzyme regulator activity;peptidase regulator activity;immunoglobulin binding; 5;2;3;3;1;2;5;5;3;5;4;3;4;4;4;4;4;5;6;7;5;6;3;3;4;3;3;4;5; K23620 IPR002345;IPR002223;IPR000566;IPR020901;IPR029856;IPR002968;IPR012674;IPR022272; Lipocalin;Pancreatic trypsin inhibitor Kunitz domain;Lipocalin/cytosolic fatty-acid binding domain;Proteinase inhibitor I2, Kunitz, conserved site;Protein AMBP;Alpha-1-microglobulin;Calycin;Lipocalin family conserved site; extracellular P02763 Alpha-1-acid glycoprotein 1 OS=Homo sapiens OX=9606 GN=ORM1 PE=1 SV=1 - [A1AG1_HUMAN] 1.084 0.763 1.154 1.141 0.757 1.565 1.420707733 4.77E-235 1.507265522 3.22E-302 1.512450852 3.04E-233 2.067371202 4.94E-94 GO:0002682;GO:0051239;GO:0002376;GO:1903556;GO:1903555;GO:0044699;GO:0032640;GO:0001816;GO:0032680;GO:0051241;GO:0050789;GO:0071706;GO:0065007;GO:0048519;GO:0032675;GO:0032720;GO:0032501;GO:0032635;GO:0006810;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0006954;GO:0002526;GO:0051234;GO:0051179;GO:0044707;GO:0050896;GO:0001817;GO:0032715;GO:0001818; regulation of immune system process;regulation of multicellular organismal process;immune system process;negative regulation of tumor necrosis factor superfamily cytokine production;regulation of tumor necrosis factor superfamily cytokine production;single-organism process;tumor necrosis factor production;cytokine production;regulation of tumor necrosis factor production;negative regulation of multicellular organismal process;regulation of biological process;tumor necrosis factor superfamily cytokine production;biological regulation;negative regulation of biological process;regulation of interleukin-6 production;negative regulation of tumor necrosis factor production;multicellular organismal process;interleukin-6 production;transport;defense response;acute-phase response;response to stress;biological_process;inflammatory response;acute inflammatory response;establishment of localization;localization;single-multicellular organism process;response to stimulus;regulation of cytokine production;negative regulation of interleukin-6 production;negative regulation of cytokine production; 3;3;2;5;5;2;6;4;6;3;2;5;2;2;5;6;2;5;4;4;7;3;1;5;6;3;2;3;2;4;5;4; GO:0043227;GO:0043226;GO:1903561;GO:0070062;GO:0072562;GO:0031982;GO:0005615;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular vesicle;extracellular exosome;blood microparticle;vesicle;extracellular space;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;3;4;3;4;3;3;1;2;2; K17308 IPR000566;IPR001500;IPR012674; Lipocalin/cytosolic fatty-acid binding domain;Alpha-1-acid glycoprotein;Calycin; extracellular Q96CX6 Leucine-rich repeat-containing protein 58 OS=Homo sapiens OX=9606 GN=LRRC58 PE=1 SV=2 - [LRC58_HUMAN] 1.162 0.847 1.276 0.945 0.877 0.997 1.371900826 nan 1.077537058 nan 1.506493506 nan 1.136830103 nan IPR003591;IPR001611;IPR032675; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Leucine-rich repeat domain, L domain-like; nucleus Hs16158332 735.0 R [R] General function prediction only; P02765 Alpha-2-HS-glycoprotein OS=Homo sapiens OX=9606 GN=AHSG PE=1 SV=2 - [FETUA_HUMAN] 1.01 1.074 0.938 1.008 1.132 0.896 0.940409683 2.42E-07 0.890459364 7.48E-19 0.873370577 0.013224613 0.791519435 0.054827466 GO:0019220;GO:0019222;GO:0051049;GO:0006907;GO:0048583;GO:0001501;GO:0001503;GO:0016043;GO:0007166;GO:0007167;GO:0030500;GO:0006909;GO:0030502;GO:0044707;GO:0031347;GO:0080090;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0009611;GO:0048513;GO:0044092;GO:0048518;GO:0048519;GO:0048585;GO:0051050;GO:0060255;GO:0030162;GO:0043434;GO:0010033;GO:0050794;GO:0042325;GO:0044700;GO:0042326;GO:0016192;GO:0009605;GO:0019538;GO:0010243;GO:0007154;GO:1900077;GO:1900076;GO:0007165;GO:0009892;GO:0007169;GO:0030282;GO:0044267;GO:0051346;GO:0044260;GO:0052547;GO:0065007;GO:0071840;GO:0065009;GO:0051130;GO:0009719;GO:0070168;GO:0050790;GO:0050793;GO:0006810;GO:0009888;GO:0070167;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0008152;GO:0002526;GO:0030278;GO:0051234;GO:0051336;GO:0051174;GO:0006897;GO:0050896;GO:1901699;GO:0051241;GO:0006954;GO:0032101;GO:0016310;GO:0051128;GO:0023057;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0010646;GO:0043086;GO:0044699;GO:0050766;GO:0050764;GO:0030279;GO:0071375;GO:1901698;GO:0010563;GO:0051246;GO:0006508;GO:1903034;GO:0032502;GO:0008286;GO:0032501;GO:1901701;GO:0009987;GO:0050727;GO:0060627;GO:0032870;GO:0032879;GO:0051093;GO:0032269;GO:0032268;GO:0009725;GO:0043170;GO:0051239;GO:0048731;GO:0045861;GO:0080134;GO:0071495;GO:0031324;GO:0031323;GO:0032869;GO:0032868;GO:0007275;GO:0071417;GO:0050789;GO:0071704;GO:0071310;GO:0010466;GO:1901652;GO:0045936;GO:0052548;GO:0046626;GO:0046627;GO:0044767;GO:0044765;GO:0044763;GO:0031214;GO:0010951;GO:0042221;GO:0051248;GO:0030100;GO:0051179;GO:1902578;GO:1901700;GO:0044238;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:1901653;GO:0006793;GO:0045807;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of metabolic process;regulation of transport;pinocytosis;regulation of response to stimulus;skeletal system development;ossification;cellular component organization;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of bone mineralization;phagocytosis;negative regulation of bone mineralization;single-multicellular organism process;regulation of defense response;regulation of primary metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;response to wounding;animal organ development;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;negative regulation of response to stimulus;positive regulation of transport;regulation of macromolecule metabolic process;regulation of proteolysis;response to peptide hormone;response to organic substance;regulation of cellular process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;vesicle-mediated transport;response to external stimulus;protein metabolic process;response to organonitrogen compound;cell communication;negative regulation of cellular response to insulin stimulus;regulation of cellular response to insulin stimulus;signal transduction;negative regulation of metabolic process;transmembrane receptor protein tyrosine kinase signaling pathway;bone mineralization;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of peptidase activity;biological regulation;cellular component organization or biogenesis;regulation of molecular function;positive regulation of cellular component organization;response to endogenous stimulus;negative regulation of biomineral tissue development;regulation of catalytic activity;regulation of developmental process;transport;tissue development;regulation of biomineral tissue development;defense response;acute-phase response;response to stress;biological_process;metabolic process;acute inflammatory response;regulation of ossification;establishment of localization;regulation of hydrolase activity;regulation of phosphorus metabolic process;endocytosis;response to stimulus;cellular response to nitrogen compound;negative regulation of multicellular organismal process;inflammatory response;regulation of response to external stimulus;phosphorylation;regulation of cellular component organization;negative regulation of signaling;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;negative regulation of catalytic activity;single-organism process;positive regulation of phagocytosis;regulation of phagocytosis;negative regulation of ossification;cellular response to peptide hormone stimulus;response to nitrogen compound;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;proteolysis;regulation of response to wounding;developmental process;insulin receptor signaling pathway;multicellular organismal process;cellular response to oxygen-containing compound;cellular process;regulation of inflammatory response;regulation of vesicle-mediated transport;cellular response to hormone stimulus;regulation of localization;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;response to hormone;macromolecule metabolic process;regulation of multicellular organismal process;system development;negative regulation of proteolysis;regulation of response to stress;cellular response to endogenous stimulus;negative regulation of cellular metabolic process;regulation of cellular metabolic process;cellular response to insulin stimulus;response to insulin;multicellular organism development;cellular response to organonitrogen compound;regulation of biological process;organic substance metabolic process;cellular response to organic substance;negative regulation of peptidase activity;response to peptide;negative regulation of phosphate metabolic process;regulation of endopeptidase activity;regulation of insulin receptor signaling pathway;negative regulation of insulin receptor signaling pathway;single-organism developmental process;single-organism transport;single-organism cellular process;biomineral tissue development;negative regulation of endopeptidase activity;response to chemical;negative regulation of protein metabolic process;regulation of endocytosis;localization;single-organism localization;response to oxygen-containing compound;primary metabolic process;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;cellular response to peptide;phosphorus metabolic process;positive regulation of endocytosis;negative regulation of cellular process;positive regulation of cellular process; 6;3;4;7;3;5;4;3;5;6;5;5;5;3;5;4;3;4;4;4;4;4;4;2;2;3;3;4;6;5;4;3;7;3;7;5;3;4;4;4;4;4;4;3;7;5;5;6;4;6;2;2;3;4;3;4;4;3;4;4;5;4;7;3;1;2;6;4;3;5;5;6;2;5;3;5;4;6;4;3;2;4;4;3;4;5;2;5;6;4;6;4;5;5;5;5;2;8;2;5;2;5;4;5;3;3;5;5;4;4;3;4;6;4;4;4;4;7;6;4;5;2;3;5;7;5;6;7;5;5;3;4;3;5;8;3;5;5;2;3;4;3;3;3;5;4;6;4;4;3;3; GO:0031982;GO:0031012;GO:0043230;GO:0044421;GO:0043227;GO:0072562;GO:0043226;GO:1903561;GO:0005615;GO:0070062;GO:0005575;GO:0005576; vesicle;extracellular matrix;extracellular organelle;extracellular region part;membrane-bounded organelle;blood microparticle;organelle;extracellular vesicle;extracellular space;extracellular exosome;cellular_component;extracellular region; 4;2;3;2;3;3;2;3;3;4;1;2; GO:0030414;GO:0098772;GO:0003674;GO:0061135;GO:0004857;GO:0004866;GO:0004869;GO:0019207;GO:0019210;GO:0030234;GO:0061134; peptidase inhibitor activity;molecular function regulator;molecular_function;endopeptidase regulator activity;enzyme inhibitor activity;endopeptidase inhibitor activity;cysteine-type endopeptidase inhibitor activity;kinase regulator activity;kinase inhibitor activity;enzyme regulator activity;peptidase regulator activity; 5;2;1;5;4;6;7;4;5;3;4; K23409 IPR000010;IPR025760;IPR001363; Cystatin domain;Fetuin-A-type cystatin domain;Proteinase inhibitor I25C, fetuin, conserved site; extracellular P02766 Transthyretin OS=Homo sapiens OX=9606 GN=TTR PE=1 SV=1 - [TTHY_HUMAN] 1.038 1.019 0.954 1.043 1.044 1.119 1.018645731 0.002282573 0.999042146 0.155236093 0.936211973 0.000268445 1.07183908 9.42E-23 GO:0006775;GO:0044700;GO:0001523;GO:0044237;GO:0010817;GO:0009583;GO:0009416;GO:0044281;GO:0007154;GO:0042572;GO:0043170;GO:0044699;GO:0044267;GO:0044710;GO:0051234;GO:0044260;GO:0016043;GO:0050789;GO:0043062;GO:0071704;GO:0030198;GO:0065007;GO:0071840;GO:0006810;GO:0009314;GO:0034308;GO:0016101;GO:0023052;GO:0009581;GO:0009582;GO:0006766;GO:0009584;GO:0006629;GO:0009628;GO:0006721;GO:0006720;GO:0034754;GO:0009987;GO:0051716;GO:0007603;GO:0007602;GO:0042445;GO:0008150;GO:0008152;GO:0044255;GO:0051179;GO:0050794;GO:0044238;GO:0065008;GO:0051606;GO:0009605;GO:0019538;GO:0050896;GO:0006066;GO:0044763;GO:1901615;GO:0007165; fat-soluble vitamin metabolic process;single organism signaling;retinoid metabolic process;cellular metabolic process;regulation of hormone levels;detection of light stimulus;response to light stimulus;small molecule metabolic process;cell communication;retinol metabolic process;macromolecule metabolic process;single-organism process;cellular protein metabolic process;single-organism metabolic process;establishment of localization;cellular macromolecule metabolic process;cellular component organization;regulation of biological process;extracellular structure organization;organic substance metabolic process;extracellular matrix organization;biological regulation;cellular component organization or biogenesis;transport;response to radiation;primary alcohol metabolic process;diterpenoid metabolic process;signaling;detection of external stimulus;detection of abiotic stimulus;vitamin metabolic process;detection of visible light;lipid metabolic process;response to abiotic stimulus;terpenoid metabolic process;isoprenoid metabolic process;cellular hormone metabolic process;cellular process;cellular response to stimulus;phototransduction, visible light;phototransduction;hormone metabolic process;biological_process;metabolic process;cellular lipid metabolic process;localization;regulation of cellular process;primary metabolic process;regulation of biological quality;detection of stimulus;response to external stimulus;protein metabolic process;response to stimulus;alcohol metabolic process;single-organism cellular process;organic hydroxy compound metabolic process;signal transduction; 6;3;8;3;4;5;5;4;4;5;4;2;5;3;3;4;3;2;4;3;5;2;2;4;4;6;7;2;4;4;5;6;4;3;6;5;4;2;3;6;5;3;1;2;4;2;3;3;3;3;3;4;2;5;3;4;4; GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0005615;GO:0043230;GO:1903561;GO:0031982;GO:0043234;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421; membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;extracellular space;extracellular organelle;extracellular vesicle;vesicle;protein complex;macromolecular complex;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part; 3;2;4;4;3;3;3;4;3;2;2;2;3;1;2;3;2; GO:0005488;GO:0003674;GO:0042802;GO:0042562;GO:0005515; binding;molecular_function;identical protein binding;hormone binding;protein binding; 2;1;4;3;3; K20731 IPR023416;IPR000895;IPR030178;IPR023418;IPR023419; Transthyretin/hydroxyisourate hydrolase, superfamily;Transthyretin/hydroxyisourate hydrolase;Transthyretin;Transthyretin, thyroxine binding site;Transthyretin, conserved site; extracellular Hs4507725 302.0 I [I] Lipid transport and metabolism; Q4ZG55 Protein GREB1 OS=Homo sapiens OX=9606 GN=GREB1 PE=2 SV=1 - [GREB1_HUMAN] 0.898 1.054 1.019 1.131 0.966 0.907 0.85199241 0.508721466 1.170807453 0.559051957 0.966793169 0.895327888 0.938923395 0.767956817 GO:0043230;GO:0070062;GO:0016021;GO:0016020;GO:0044421;GO:0005575;GO:0005576;GO:0044425;GO:1903561;GO:0043227;GO:0043226;GO:0031224;GO:0031982; extracellular organelle;extracellular exosome;integral component of membrane;membrane;extracellular region part;cellular_component;extracellular region;membrane part;extracellular vesicle;membrane-bounded organelle;organelle;intrinsic component of membrane;vesicle; 3;4;4;2;2;1;2;2;3;3;2;3;4; IPR028422; GREB1; plasma membrane P07357 Complement component C8 alpha chain OS=Homo sapiens OX=9606 GN=C8A PE=1 SV=2 - [CO8A_HUMAN] 0.997 0.948 1.099 1.034 0.923 1.119 1.051687764 0.083367524 1.120260022 0.004236522 1.1592827 1.62E-05 1.212351029 0.00364816 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:0019724;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0019835;GO:0002684;GO:0002682;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0006957;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0002697;GO:0006956;GO:1903317;GO:0008152;GO:0032101;GO:0009611;GO:0044699;GO:0002443;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0016485;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044238;GO:0002250;GO:0002253;GO:0002252; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;cytolysis;positive regulation of immune system process;regulation of immune system process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;complement activation, alternative pathway;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;regulation of immune effector process;complement activation;regulation of protein maturation;metabolic process;regulation of response to external stimulus;response to wounding;single-organism process;leukocyte mediated immunity;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;protein processing;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;primary metabolic process;adaptive immune response;activation of immune response;immune effector process; 4;3;3;3;5;5;3;5;2;2;6;4;4;6;6;3;4;2;5;5;2;3;3;3;4;3;7;1;5;5;3;6;5;4;7;5;2;4;4;6;2;4;4;2;4;5;5;5;2;6;4;5;4;4;4;3;3;5;5;4;5;3;4;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0072562;GO:0031224;GO:0031226;GO:0046930;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0005575;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0098797;GO:0098796;GO:0005576;GO:0005579; vesicle;integral component of membrane;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;blood microparticle;intrinsic component of membrane;intrinsic component of plasma membrane;pore complex;plasma membrane part;cell part;cell;cell periphery;cellular_component;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;plasma membrane protein complex;membrane protein complex;extracellular region;membrane attack complex; 4;4;2;3;3;2;2;3;3;3;4;4;3;2;2;3;1;4;2;4;3;3;3;2;4;3;2;5; K03997 map04610;map05020;map05146;map05322; Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus; IPR016186;IPR023415;IPR000884;IPR009030;IPR020864;IPR020863;IPR001862;IPR002172; C-type lectin-like/link domain;Low-density lipoprotein (LDL) receptor class A, conserved site;Thrombospondin type-1 (TSP1) repeat;Growth factor receptor cysteine-rich domain;Membrane attack complex component/perforin (MACPF) domain;Membrane attack complex component/perforin domain, conserved site;Membrane attack complex component/perforin/complement C9;Low-density lipoprotein (LDL) receptor class A repeat; extracellular Q9HCK0 Zinc finger and BTB domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZBTB26 PE=1 SV=2 - [ZBT26_HUMAN] 0.899 1.106 0.949 0.758 1.527 0.673 0.81283906 0.243242415 0.496398166 0.004639464 0.858047016 0.371116696 0.440733464 0.032113626 GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; K10505 IPR011333;IPR000210;IPR013087; SKP1/BTB/POZ domain;BTB/POZ domain;Zinc finger C2H2-type; nucleus Hs18141299 920.0 R [R] General function prediction only; P07359 Platelet glycoprotein Ib alpha chain OS=Homo sapiens OX=9606 GN=GP1BA PE=1 SV=2 - [GP1BA_HUMAN] 1.028 0.802 1.278 0.97 0.873 0.785 1.281795511 0.650585745 1.111111111 0.658410536 1.593516209 0.493944277 0.899198167 0.738754604 GO:0051348;GO:0007599;GO:0080090;GO:0019222;GO:0048585;GO:0007596;GO:0048583;GO:0007165;GO:0007166;GO:0019220;GO:0071840;GO:0019221;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0048869;GO:0009611;GO:0044092;GO:0048519;GO:0007597;GO:0060255;GO:0045859;GO:0042221;GO:0010033;GO:0030168;GO:0042325;GO:0044700;GO:0042326;GO:0009605;GO:0044707;GO:0019538;GO:0030193;GO:0033673;GO:0009892;GO:0035556;GO:0043170;GO:0044267;GO:0009653;GO:0000902;GO:0044260;GO:0043549;GO:0016043;GO:1900046;GO:1900047;GO:0065007;GO:0065009;GO:0065008;GO:0007186;GO:0034097;GO:0050790;GO:0044710;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:1902532;GO:0031400;GO:1902531;GO:0050818;GO:0050819;GO:0044767;GO:0042730;GO:0071345;GO:0050896;GO:0043412;GO:0051338;GO:0036211;GO:0030195;GO:0010563;GO:0032102;GO:0008152;GO:0032101;GO:0001775;GO:0016310;GO:0023057;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0010646;GO:0043086;GO:0044699;GO:0051248;GO:0051241;GO:0051246;GO:0007259;GO:0031399;GO:0022610;GO:1903034;GO:1903035;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0032269;GO:0032268;GO:1904893;GO:1904892;GO:0080134;GO:0061045;GO:0031324;GO:0031323;GO:0061041;GO:0070493;GO:0072376;GO:0072378;GO:0006796;GO:0050789;GO:0071704;GO:0071310;GO:0097696;GO:0045936;GO:0006468;GO:0006469;GO:0046426;GO:0046425;GO:0006464;GO:0051174;GO:0044763;GO:0007155;GO:0007154;GO:0044238;GO:0048856;GO:0044237;GO:0032989;GO:0006793;GO:0001933;GO:0001932;GO:0048523; negative regulation of transferase activity;hemostasis;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;regulation of phosphate metabolic process;cellular component organization or biogenesis;cytokine-mediated signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;response to wounding;negative regulation of molecular function;negative regulation of biological process;blood coagulation, intrinsic pathway;regulation of macromolecule metabolic process;regulation of protein kinase activity;response to chemical;response to organic substance;platelet activation;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;response to external stimulus;single-multicellular organism process;protein metabolic process;regulation of blood coagulation;negative regulation of kinase activity;negative regulation of metabolic process;intracellular signal transduction;macromolecule metabolic process;cellular protein metabolic process;anatomical structure morphogenesis;cell morphogenesis;cellular macromolecule metabolic process;regulation of kinase activity;cellular component organization;regulation of hemostasis;negative regulation of hemostasis;biological regulation;regulation of molecular function;regulation of biological quality;G-protein coupled receptor signaling pathway;response to cytokine;regulation of catalytic activity;single-organism metabolic process;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;regulation of multicellular organismal process;negative regulation of intracellular signal transduction;negative regulation of protein modification process;regulation of intracellular signal transduction;regulation of coagulation;negative regulation of coagulation;single-organism developmental process;fibrinolysis;cellular response to cytokine stimulus;response to stimulus;macromolecule modification;regulation of transferase activity;protein modification process;negative regulation of blood coagulation;negative regulation of phosphorus metabolic process;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;cell activation;phosphorylation;negative regulation of signaling;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;JAK-STAT cascade;regulation of protein modification process;biological adhesion;regulation of response to wounding;negative regulation of response to wounding;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;negative regulation of STAT cascade;regulation of STAT cascade;regulation of response to stress;negative regulation of wound healing;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of wound healing;thrombin receptor signaling pathway;protein activation cascade;blood coagulation, fibrin clot formation;phosphate-containing compound metabolic process;regulation of biological process;organic substance metabolic process;cellular response to organic substance;STAT cascade;negative regulation of phosphate metabolic process;protein phosphorylation;negative regulation of protein kinase activity;negative regulation of JAK-STAT cascade;regulation of JAK-STAT cascade;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;cell adhesion;cell communication;primary metabolic process;anatomical structure development;cellular metabolic process;cellular component morphogenesis;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process; 6;5;4;3;3;5;3;4;5;6;2;6;3;4;4;4;4;4;4;2;4;4;7;3;4;5;7;3;7;3;3;4;5;7;3;5;4;5;3;5;4;6;3;4;4;2;3;3;5;5;4;3;5;3;3;4;1;3;5;6;5;4;4;3;6;6;2;5;5;5;5;5;4;2;4;4;6;3;2;4;4;3;4;5;2;5;3;5;7;6;2;5;4;2;2;4;2;5;5;6;6;4;5;4;4;6;6;3;4;5;2;3;5;6;6;7;8;7;7;6;5;3;3;4;3;3;3;4;4;7;7;3; GO:0031982;GO:0016021;GO:0016020;GO:0031225;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0046658;GO:0043227;GO:0043226;GO:0031224;GO:0044424;GO:0031226;GO:0005737;GO:0009986;GO:0031233;GO:0031362;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098552;GO:0070062;GO:0005887;GO:0005886;GO:1903561;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;anchored component of membrane;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;anchored component of plasma membrane;membrane-bounded organelle;organelle;intrinsic component of membrane;intracellular part;intrinsic component of plasma membrane;cytoplasm;cell surface;intrinsic component of external side of plasma membrane;anchored component of external side of plasma membrane;plasma membrane part;cell part;cell;intracellular;cell periphery;side of membrane;extracellular exosome;integral component of plasma membrane;plasma membrane;extracellular vesicle;cellular_component;extracellular region; 4;4;2;4;3;2;2;4;4;3;2;3;3;4;4;3;5;5;3;2;2;3;3;3;4;4;3;3;1;2; GO:0060089;GO:0098772;GO:0099600;GO:0003674;GO:0004930;GO:0019887;GO:0004857;GO:0019207;GO:0004860;GO:0001653;GO:0015057;GO:0038023;GO:0004872;GO:0004871;GO:0008528;GO:0019210;GO:0030234;GO:0004888; molecular transducer activity;molecular function regulator;transmembrane receptor activity;molecular_function;G-protein coupled receptor activity;protein kinase regulator activity;enzyme inhibitor activity;kinase regulator activity;protein kinase inhibitor activity;peptide receptor activity;thrombin receptor activity;signaling receptor activity;receptor activity;signal transducer activity;G-protein coupled peptide receptor activity;kinase inhibitor activity;enzyme regulator activity;transmembrane signaling receptor activity; 2;2;4;1;5;5;4;4;6;4;6;3;3;2;5;5;3;4; K06261 map04512;map04611;map04640; ECM-receptor interaction;Platelet activation;Hematopoietic cell lineage; IPR003591;IPR032675;IPR000483;IPR000372;IPR001611; Leucine-rich repeat, typical subtype;Leucine-rich repeat domain, L domain-like;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat N-terminal domain;Leucine-rich repeat; extracellular Hs4504071 1235.0 R [R] General function prediction only; P07358 Complement component C8 beta chain OS=Homo sapiens OX=9606 GN=C8B PE=1 SV=3 - [CO8B_HUMAN] 1.058 0.922 1.13 0.993 0.936 1.004 1.147505423 2.97E-05 1.060897436 0.049284573 1.225596529 2.18E-05 1.072649573 0.021589989 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:0019724;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0019835;GO:0002684;GO:0002682;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0006957;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0002697;GO:0006956;GO:1903317;GO:0008152;GO:0032101;GO:0009611;GO:0044699;GO:0002443;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0016485;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044238;GO:0002250;GO:0002253;GO:0002252; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;cytolysis;positive regulation of immune system process;regulation of immune system process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;complement activation, alternative pathway;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;regulation of immune effector process;complement activation;regulation of protein maturation;metabolic process;regulation of response to external stimulus;response to wounding;single-organism process;leukocyte mediated immunity;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;protein processing;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;primary metabolic process;adaptive immune response;activation of immune response;immune effector process; 4;3;3;3;5;5;3;5;2;2;6;4;4;6;6;3;4;2;5;5;2;3;3;3;4;3;7;1;5;5;3;6;5;4;7;5;2;4;4;6;2;4;4;2;4;5;5;5;2;6;4;5;4;4;4;3;3;5;5;4;5;3;4;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0031224;GO:0031226;GO:0046930;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0005575;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0098797;GO:0098796;GO:0005576;GO:0005579; vesicle;integral component of membrane;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;intrinsic component of membrane;intrinsic component of plasma membrane;pore complex;plasma membrane part;cell part;cell;cell periphery;cellular_component;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;plasma membrane protein complex;membrane protein complex;extracellular region;membrane attack complex; 4;4;2;3;3;2;2;3;3;4;4;3;2;2;3;1;4;2;4;3;3;3;2;4;3;2;5; K03998 map04610;map05020;map05146;map05322; Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus; IPR023415;IPR002172;IPR020864;IPR020863;IPR001862;IPR000884; Low-density lipoprotein (LDL) receptor class A, conserved site;Low-density lipoprotein (LDL) receptor class A repeat;Membrane attack complex component/perforin (MACPF) domain;Membrane attack complex component/perforin domain, conserved site;Membrane attack complex component/perforin/complement C9;Thrombospondin type-1 (TSP1) repeat; extracellular P02649 Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1 - [APOE_HUMAN] 0.849 1.102 1.135 0.887 1.036 1.282 0.770417423 6.99E-30 0.856177606 6.45E-09 1.029945554 0.000641536 1.237451737 1.02E-09 GO:0051043;GO:0051044;GO:0043954;GO:0007596;GO:0016358;GO:0009165;GO:0044281;GO:0044282;GO:0044283;GO:0098771;GO:0007599;GO:2001139;GO:2001138;GO:0051651;GO:0051716;GO:0048589;GO:0000165;GO:0051049;GO:0016101;GO:0009190;GO:0044794;GO:1990138;GO:0060548;GO:0045859;GO:0008361;GO:0046486;GO:2000644;GO:0042325;GO:0042326;GO:0010631;GO:0010632;GO:0010633;GO:0019538;GO:0072359;GO:0009896;GO:0009894;GO:0009892;GO:0009893;GO:0009890;GO:1903002;GO:0097090;GO:0090261;GO:0000302;GO:0031175;GO:0035556;GO:0071900;GO:0050789;GO:0051341;GO:0000904;GO:0000902;GO:0051348;GO:0097006;GO:1901360;GO:1901566;GO:0018130;GO:0006629;GO:0009260;GO:0043412;GO:0032489;GO:0032488;GO:1901631;GO:0048812;GO:0006695;GO:0006694;GO:0044802;GO:0006753;GO:0044085;GO:0034250;GO:0048638;GO:0051246;GO:0001775;GO:0033619;GO:0051129;GO:0051128;GO:0042176;GO:0009416;GO:0072657;GO:0050435;GO:0051235;GO:0030810;GO:0051234;GO:0060284;GO:0048514;GO:0008285;GO:0050878;GO:0008283;GO:0006875;GO:0006874;GO:0006873;GO:1902930;GO:0001558;GO:0007409;GO:0044257;GO:0046889;GO:0044255;GO:0030258;GO:0006979;GO:0046503;GO:1901630;GO:0034380;GO:0006898;GO:0030030;GO:0010894;GO:0042592;GO:0061041;GO:0031328;GO:0034384;GO:0061045;GO:0007271;GO:0008219;GO:0007275;GO:0031102;GO:0009636;GO:0055092;GO:0043067;GO:0043066;GO:0015849;GO:0043069;GO:0009605;GO:0090090;GO:0006468;GO:0006469;GO:0006707;GO:0006706;GO:0019216;GO:0019219;GO:0019218;GO:0006464;GO:0044767;GO:0044765;GO:0044764;GO:0044763;GO:0071830;GO:0040011;GO:0045184;GO:0051271;GO:0040012;GO:0010594;GO:0010596;GO:0048856;GO:0006182;GO:1990748;GO:0019693;GO:0006066;GO:0006796;GO:2000026;GO:0006793;GO:0048524;GO:0043113;GO:0043112;GO:0023057;GO:0048523;GO:0048522;GO:0048675;GO:0008104;GO:0034447;GO:0031348;GO:0043523;GO:0043524;GO:0007165;GO:0007166;GO:0003018;GO:0031345;GO:0031344;GO:0031347;GO:0031346;GO:0044712;GO:0044710;GO:0044711;GO:0070841;GO:0033673;GO:0050727;GO:0052652;GO:0098869;GO:0045664;GO:0060998;GO:0045666;GO:0044093;GO:0044092;GO:0033036;GO:0060996;GO:1902951;GO:1902952;GO:0051055;GO:0051051;GO:0051050;GO:0034368;GO:0034369;GO:0034205;GO:1902653;GO:1902652;GO:2001140;GO:0051668;GO:0051702;GO:0051704;GO:0031667;GO:1900371;GO:0044788;GO:0006140;GO:0051000;GO:0010648;GO:0016055;GO:0015918;GO:0015850;GO:0015914;GO:0061000;GO:0006807;GO:0042311;GO:0044242;GO:0044267;GO:0010646;GO:0044260;GO:0070997;GO:0001568;GO:0043086;GO:0098916;GO:0043409;GO:0097242;GO:0043408;GO:0007186;GO:0034613;GO:0050793;GO:0050792;GO:0032768;GO:0050790;GO:0009889;GO:0050794;GO:0060070;GO:1901700;GO:0051239;GO:1901216;GO:1901214;GO:1901215;GO:0090407;GO:1900373;GO:0055088;GO:0051174;GO:0006897;GO:0032368;GO:0032369;GO:0034382;GO:0050896;GO:0034381;GO:0046390;GO:0051338;GO:0051962;GO:0051961;GO:0051960;GO:2000145;GO:0060828;GO:2000146;GO:0006518;GO:0010562;GO:0034377;GO:0010563;GO:0032102;GO:0032101;GO:0009314;GO:0006639;GO:0006638;GO:0043407;GO:0043405;GO:0022607;GO:1903001;GO:0009259;GO:0044699;GO:1903000;GO:0050767;GO:0051248;GO:0032799;GO:0001941;GO:0051240;GO:0051241;GO:0031099;GO:0051247;GO:0050768;GO:0050769;GO:0010769;GO:0031399;GO:0046942;GO:1903034;GO:1903035;GO:0016126;GO:0050999;GO:0016125;GO:0030178;GO:0046068;GO:0002021;GO:0040013;GO:0034249;GO:0034248;GO:0043270;GO:0043271;GO:0051270;GO:0009891;GO:0090132;GO:0090130;GO:0030808;GO:1901137;GO:0030804;GO:1901135;GO:0030801;GO:0048167;GO:0030802;GO:0048731;GO:0016127;GO:0043933;GO:0050866;GO:0046890;GO:0072521;GO:0072522;GO:0042158;GO:0042159;GO:1900544;GO:0042981;GO:0048168;GO:1901627;GO:1901626;GO:1901629;GO:1901628;GO:1903364;GO:0046164;GO:0045935;GO:0030182;GO:0045936;GO:0045939;GO:1990379;GO:0007268;GO:0007267;GO:0042221;GO:0022008;GO:0007264;GO:0007263;GO:0090083;GO:0008610;GO:0006996;GO:0009628;GO:1902580;GO:0055089;GO:0044237;GO:0097114;GO:0097113;GO:0090206;GO:0044403;GO:0006775;GO:0019220;GO:0019222;GO:0048588;GO:0001523;GO:0048585;GO:0048468;GO:0007266;GO:0072358;GO:1901362;GO:0045981;GO:0071840;GO:1901361;GO:0009968;GO:0009966;GO:0048869;GO:0019058;GO:0051817;GO:0055086;GO:0010720;GO:0010721;GO:0048518;GO:0048519;GO:1902988;GO:0042127;GO:0015718;GO:0015711;GO:0007603;GO:0007602;GO:0043537;GO:0043535;GO:0043534;GO:0003008;GO:0044700;GO:1901564;GO:0016192;GO:0044707;GO:0061024;GO:0003013;GO:1902947;GO:0033554;GO:0019637;GO:1902004;GO:1902003;GO:0032535;GO:0022604;GO:0034375;GO:0034374;GO:0034372;GO:0022603;GO:0006928;GO:0051674;GO:0042157;GO:0098754;GO:0015909;GO:0042987;GO:0042982;GO:0043542;GO:0043549;GO:0090066;GO:1900046;GO:1900047;GO:0016477;GO:0033700;GO:0035150;GO:0061564;GO:0015908;GO:0006811;GO:0006810;GO:0050728;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0050810;GO:0006954;GO:1902532;GO:0010605;GO:1902531;GO:0050818;GO:0050819;GO:0043902;GO:0051606;GO:0046907;GO:0043903;GO:0080134;GO:0072578;GO:0043900;GO:1902430;GO:1901616;GO:1901617;GO:0099536;GO:0099537;GO:0032770;GO:0032805;GO:0032803;GO:0032802;GO:0032801;GO:0019068;GO:0030154;GO:1902991;GO:1902992;GO:1902993;GO:1902994;GO:1902995;GO:1902996;GO:0035023;GO:1902998;GO:1902999;GO:0045665;GO:0050880;GO:0032375;GO:0032374;GO:0032376;GO:0032371;GO:0032370;GO:0051851;GO:0032372;GO:0050865;GO:0060999;GO:0032270;GO:2000171;GO:0006509;GO:0006508;GO:0060560;GO:0032502;GO:0032501;GO:0006641;GO:0006721;GO:0031331;GO:0009987;GO:0006725;GO:0030003;GO:0030799;GO:0044271;GO:0032879;GO:0050678;GO:0050770;GO:0050773;GO:1902950;GO:0045541;GO:0006139;GO:0031400;GO:0030111;GO:0009187;GO:0051056;GO:0045540;GO:0045937;GO:0043269;GO:0044070;GO:1900006;GO:0034367;GO:0032989;GO:0071704;GO:0034433;GO:0034434;GO:0034435;GO:0071702;GO:1901293;GO:0030336;GO:0030334;GO:0006915;GO:0009058;GO:0009059;GO:0009117;GO:0051171;GO:0051172;GO:0051173;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0001936;GO:0010977;GO:1901615;GO:0034654;GO:0048844;GO:0010976;GO:0050804;GO:0080090;GO:0050680;GO:0006820;GO:0055074;GO:0010873;GO:0061387;GO:0023014;GO:0097061;GO:0097062;GO:0010604;GO:0070727;GO:0048858;GO:0009611;GO:0044419;GO:0045833;GO:0045834;GO:0030168;GO:0050673;GO:0007010;GO:0019725;GO:0006766;GO:0060255;GO:0046578;GO:0090370;GO:0030162;GO:0030163;GO:0010975;GO:0010872;GO:0030516;GO:0010876;GO:0010874;GO:0010875;GO:0048870;GO:0048878;GO:0006163;GO:0019433;GO:0006164;GO:0030193;GO:0019438;GO:0030195;GO:1903793;GO:1903792;GO:0048667;GO:0090181;GO:0019934;GO:0019935;GO:0019932;GO:0009057;GO:0051353;GO:1901576;GO:1901575;GO:0016049;GO:1903362;GO:0046483;GO:0016043;GO:0016042;GO:0065003;GO:0010544;GO:0065007;GO:0010543;GO:0065005;GO:1902931;GO:2000646;GO:0065009;GO:0065008;GO:0051130;GO:0008015;GO:0009152;GO:0042060;GO:0009150;GO:0036211;GO:0008150;GO:0008152;GO:0042632;GO:0030826;GO:0045732;GO:0034370;GO:0050808;GO:0006869;GO:0050803;GO:0016310;GO:0050801;GO:0055065;GO:0050807;GO:0030301;GO:0044248;GO:0044249;GO:0034641;GO:0023052;GO:0032373;GO:0034645;GO:0023051;GO:0001667;GO:0009653;GO:0007265;GO:0043085;GO:0072507;GO:0072503;GO:0051649;GO:1900221;GO:0046464;GO:0030823;GO:0046461;GO:0044238;GO:0046165;GO:0017038;GO:0030825;GO:0048583;GO:0045597;GO:0045596;GO:0045595;GO:0071901;GO:0055080;GO:0055081;GO:0055082;GO:0008202;GO:0008203;GO:0051093;GO:0032269;GO:0032268;GO:0043603;GO:0051094;GO:0043170;GO:0045940;GO:0097688;GO:0045862;GO:0043691;GO:0009991;GO:0031329;GO:0001944;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0010942;GO:0010941;GO:0071825;GO:0071827;GO:0040007;GO:0040008;GO:0010467;GO:0006720;GO:0010468;GO:0048666;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0051402;GO:0044265;GO:0007154;GO:0048699;GO:1900542;GO:0032990;GO:0007399;GO:0001935;GO:0030828;GO:0044087;GO:0033344;GO:0016032;GO:0015748;GO:0015031;GO:0001933;GO:0001932;GO:0060840;GO:0035821;GO:0001937;GO:0044089; regulation of membrane protein ectodomain proteolysis;positive regulation of membrane protein ectodomain proteolysis;cellular component maintenance;blood coagulation;dendrite development;nucleotide biosynthetic process;small molecule metabolic process;small molecule catabolic process;small molecule biosynthetic process;inorganic ion homeostasis;hemostasis;negative regulation of phospholipid transport;regulation of phospholipid transport;maintenance of location in cell;cellular response to stimulus;developmental growth;MAPK cascade;regulation of transport;diterpenoid metabolic process;cyclic nucleotide biosynthetic process;positive regulation by host of viral process;neuron projection extension;negative regulation of cell death;regulation of protein kinase activity;regulation of cell size;glycerolipid metabolic process;regulation of receptor catabolic process;regulation of phosphorylation;negative regulation of phosphorylation;epithelial cell migration;regulation of epithelial cell migration;negative regulation of epithelial cell migration;protein metabolic process;circulatory system development;positive regulation of catabolic process;regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of lipid transport across blood brain barrier;presynaptic membrane organization;positive regulation of inclusion body assembly;response to reactive oxygen species;neuron projection development;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;regulation of oxidoreductase activity;cell morphogenesis involved in differentiation;cell morphogenesis;negative regulation of transferase activity;regulation of plasma lipoprotein particle levels;organic cyclic compound metabolic process;organonitrogen compound biosynthetic process;heterocycle biosynthetic process;lipid metabolic process;ribonucleotide biosynthetic process;macromolecule modification;regulation of Cdc42 protein signal transduction;Cdc42 protein signal transduction;positive regulation of presynaptic membrane organization;neuron projection morphogenesis;cholesterol biosynthetic process;steroid biosynthetic process;single-organism membrane organization;nucleoside phosphate metabolic process;cellular component biogenesis;positive regulation of cellular amide metabolic process;regulation of developmental growth;regulation of protein metabolic process;cell activation;membrane protein proteolysis;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein catabolic process;response to light stimulus;protein localization to membrane;beta-amyloid metabolic process;maintenance of location;positive regulation of nucleotide biosynthetic process;establishment of localization;regulation of cell development;blood vessel morphogenesis;negative regulation of cell proliferation;regulation of body fluid levels;cell proliferation;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular ion homeostasis;regulation of alcohol biosynthetic process;regulation of cell growth;axonogenesis;cellular protein catabolic process;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;lipid modification;response to oxidative stress;glycerolipid catabolic process;negative regulation of presynaptic membrane organization;high-density lipoprotein particle assembly;receptor-mediated endocytosis;cell projection organization;negative regulation of steroid biosynthetic process;homeostatic process;regulation of wound healing;positive regulation of cellular biosynthetic process;high-density lipoprotein particle clearance;negative regulation of wound healing;synaptic transmission, cholinergic;cell death;multicellular organism development;neuron projection regeneration;response to toxic substance;sterol homeostasis;regulation of programmed cell death;negative regulation of apoptotic process;organic acid transport;negative regulation of programmed cell death;response to external stimulus;negative regulation of canonical Wnt signaling pathway;protein phosphorylation;negative regulation of protein kinase activity;cholesterol catabolic process;steroid catabolic process;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of steroid metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;multi-organism cellular process;single-organism cellular process;triglyceride-rich lipoprotein particle clearance;locomotion;establishment of protein localization;negative regulation of cellular component movement;regulation of locomotion;regulation of endothelial cell migration;negative regulation of endothelial cell migration;anatomical structure development;cGMP biosynthetic process;cellular detoxification;ribose phosphate metabolic process;alcohol metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;positive regulation of viral process;receptor clustering;receptor metabolic process;negative regulation of signaling;negative regulation of cellular process;positive regulation of cellular process;axon extension;protein localization;very-low-density lipoprotein particle clearance;negative regulation of defense response;regulation of neuron apoptotic process;negative regulation of neuron apoptotic process;signal transduction;cell surface receptor signaling pathway;vascular process in circulatory system;negative regulation of cell projection organization;regulation of cell projection organization;regulation of defense response;positive regulation of cell projection organization;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;inclusion body assembly;negative regulation of kinase activity;regulation of inflammatory response;cyclic purine nucleotide metabolic process;cellular oxidant detoxification;regulation of neuron differentiation;regulation of dendritic spine development;positive regulation of neuron differentiation;positive regulation of molecular function;negative regulation of molecular function;macromolecule localization;dendritic spine development;negative regulation of dendritic spine maintenance;positive regulation of dendritic spine maintenance;negative regulation of lipid biosynthetic process;negative regulation of transport;positive regulation of transport;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;beta-amyloid formation;secondary alcohol biosynthetic process;secondary alcohol metabolic process;positive regulation of phospholipid transport;localization within membrane;interaction with symbiont;multi-organism process;response to nutrient levels;regulation of purine nucleotide biosynthetic process;modulation by host of viral process;regulation of nucleotide metabolic process;positive regulation of nitric-oxide synthase activity;negative regulation of cell communication;Wnt signaling pathway;sterol transport;organic hydroxy compound transport;phospholipid transport;negative regulation of dendritic spine development;nitrogen compound metabolic process;vasodilation;cellular lipid catabolic process;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;neuron death;blood vessel development;negative regulation of catalytic activity;anterograde trans-synaptic signaling;negative regulation of MAPK cascade;beta-amyloid clearance;regulation of MAPK cascade;G-protein coupled receptor signaling pathway;cellular protein localization;regulation of developmental process;regulation of viral process;regulation of monooxygenase activity;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;canonical Wnt signaling pathway;response to oxygen-containing compound;regulation of multicellular organismal process;positive regulation of neuron death;regulation of neuron death;negative regulation of neuron death;organophosphate biosynthetic process;positive regulation of purine nucleotide biosynthetic process;lipid homeostasis;regulation of phosphorus metabolic process;endocytosis;regulation of lipid transport;negative regulation of lipid transport;chylomicron remnant clearance;response to stimulus;plasma lipoprotein particle clearance;ribose phosphate biosynthetic process;regulation of transferase activity;positive regulation of nervous system development;negative regulation of nervous system development;regulation of nervous system development;regulation of cell motility;regulation of canonical Wnt signaling pathway;negative regulation of cell motility;peptide metabolic process;positive regulation of phosphorus metabolic process;plasma lipoprotein particle assembly;negative regulation of phosphorus metabolic process;negative regulation of response to external stimulus;regulation of response to external stimulus;response to radiation;acylglycerol metabolic process;neutral lipid metabolic process;negative regulation of MAP kinase activity;regulation of MAP kinase activity;cellular component assembly;negative regulation of lipid transport across blood brain barrier;ribonucleotide metabolic process;single-organism process;regulation of lipid transport across blood brain barrier;regulation of neurogenesis;negative regulation of protein metabolic process;low-density lipoprotein receptor particle metabolic process;postsynaptic membrane organization;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regeneration;positive regulation of protein metabolic process;negative regulation of neurogenesis;positive regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;carboxylic acid transport;regulation of response to wounding;negative regulation of response to wounding;sterol biosynthetic process;regulation of nitric-oxide synthase activity;sterol metabolic process;negative regulation of Wnt signaling pathway;cGMP metabolic process;response to dietary excess;negative regulation of locomotion;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;positive regulation of ion transport;negative regulation of ion transport;regulation of cellular component movement;positive regulation of biosynthetic process;epithelium migration;tissue migration;regulation of nucleotide biosynthetic process;carbohydrate derivative biosynthetic process;positive regulation of cyclic nucleotide biosynthetic process;carbohydrate derivative metabolic process;positive regulation of cyclic nucleotide metabolic process;regulation of synaptic plasticity;regulation of cyclic nucleotide biosynthetic process;system development;sterol catabolic process;macromolecular complex subunit organization;negative regulation of cell activation;regulation of lipid biosynthetic process;purine-containing compound metabolic process;purine-containing compound biosynthetic process;lipoprotein biosynthetic process;lipoprotein catabolic process;positive regulation of purine nucleotide metabolic process;regulation of apoptotic process;regulation of neuronal synaptic plasticity;negative regulation of postsynaptic membrane organization;regulation of postsynaptic membrane organization;regulation of presynaptic membrane organization;positive regulation of postsynaptic membrane organization;positive regulation of cellular protein catabolic process;alcohol catabolic process;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;negative regulation of phosphate metabolic process;negative regulation of steroid metabolic process;lipid transport across blood brain barrier;synaptic transmission;cell-cell signaling;response to chemical;neurogenesis;small GTPase mediated signal transduction;nitric oxide mediated signal transduction;regulation of inclusion body assembly;lipid biosynthetic process;organelle organization;response to abiotic stimulus;single-organism cellular localization;fatty acid homeostasis;cellular metabolic process;NMDA glutamate receptor clustering;AMPA glutamate receptor clustering;negative regulation of cholesterol metabolic process;symbiosis, encompassing mutualism through parasitism;fat-soluble vitamin metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;developmental cell growth;retinoid metabolic process;negative regulation of response to stimulus;cell development;Rho protein signal transduction;cardiovascular system development;organic cyclic compound biosynthetic process;positive regulation of nucleotide metabolic process;cellular component organization or biogenesis;organic cyclic compound catabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;nucleobase-containing small molecule metabolic process;positive regulation of cell development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;neurofibrillary tangle assembly;regulation of cell proliferation;monocarboxylic acid transport;organic anion transport;phototransduction, visible light;phototransduction;negative regulation of blood vessel endothelial cell migration;regulation of blood vessel endothelial cell migration;blood vessel endothelial cell migration;system process;single organism signaling;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;membrane organization;circulatory system process;regulation of tau-protein kinase activity;cellular response to stress;organophosphate metabolic process;positive regulation of beta-amyloid formation;regulation of beta-amyloid formation;regulation of cellular component size;regulation of cell morphogenesis;high-density lipoprotein particle remodeling;low-density lipoprotein particle remodeling;very-low-density lipoprotein particle remodeling;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;lipoprotein metabolic process;detoxification;long-chain fatty acid transport;amyloid precursor protein catabolic process;amyloid precursor protein metabolic process;endothelial cell migration;regulation of kinase activity;regulation of anatomical structure size;regulation of hemostasis;negative regulation of hemostasis;cell migration;phospholipid efflux;regulation of tube size;axon development;fatty acid transport;ion transport;transport;negative regulation of inflammatory response;defense response;programmed cell death;response to stress;coagulation;regulation of steroid biosynthetic process;inflammatory response;negative regulation of intracellular signal transduction;negative regulation of macromolecule metabolic process;regulation of intracellular signal transduction;regulation of coagulation;negative regulation of coagulation;positive regulation of multi-organism process;detection of stimulus;intracellular transport;regulation of symbiosis, encompassing mutualism through parasitism;regulation of response to stress;neurotransmitter-gated ion channel clustering;regulation of multi-organism process;negative regulation of beta-amyloid formation;organic hydroxy compound catabolic process;organic hydroxy compound biosynthetic process;synaptic signaling;trans-synaptic signaling;positive regulation of monooxygenase activity;positive regulation of low-density lipoprotein particle receptor catabolic process;regulation of low-density lipoprotein particle receptor catabolic process;low-density lipoprotein particle receptor catabolic process;receptor catabolic process;virion assembly;cell differentiation;regulation of amyloid precursor protein catabolic process;negative regulation of amyloid precursor protein catabolic process;positive regulation of amyloid precursor protein catabolic process;regulation of phospholipid efflux;positive regulation of phospholipid efflux;regulation of neurofibrillary tangle assembly;regulation of Rho protein signal transduction;positive regulation of neurofibrillary tangle assembly;negative regulation of phospholipid efflux;negative regulation of neuron differentiation;regulation of blood vessel size;negative regulation of cholesterol transport;regulation of cholesterol transport;positive regulation of cholesterol transport;regulation of sterol transport;positive regulation of lipid transport;modification by host of symbiont morphology or physiology;negative regulation of sterol transport;regulation of cell activation;positive regulation of dendritic spine development;positive regulation of cellular protein metabolic process;negative regulation of dendrite development;membrane protein ectodomain proteolysis;proteolysis;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;triglyceride metabolic process;terpenoid metabolic process;positive regulation of cellular catabolic process;cellular process;cellular aromatic compound metabolic process;cellular cation homeostasis;regulation of cyclic nucleotide metabolic process;cellular nitrogen compound biosynthetic process;regulation of localization;regulation of epithelial cell proliferation;regulation of axonogenesis;regulation of dendrite development;regulation of dendritic spine maintenance;negative regulation of cholesterol biosynthetic process;nucleobase-containing compound metabolic process;negative regulation of protein modification process;regulation of Wnt signaling pathway;cyclic nucleotide metabolic process;regulation of small GTPase mediated signal transduction;regulation of cholesterol biosynthetic process;positive regulation of phosphate metabolic process;regulation of ion transport;regulation of anion transport;positive regulation of dendrite development;macromolecular complex remodeling;cellular component morphogenesis;organic substance metabolic process;steroid esterification;sterol esterification;cholesterol esterification;organic substance transport;nucleoside phosphate biosynthetic process;negative regulation of cell migration;regulation of cell migration;apoptotic process;biosynthetic process;macromolecule biosynthetic process;nucleotide metabolic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;catabolic process;localization;single-organism localization;cellular localization;regulation of endothelial cell proliferation;negative regulation of neuron projection development;organic hydroxy compound metabolic process;nucleobase-containing compound biosynthetic process;artery morphogenesis;positive regulation of neuron projection development;modulation of synaptic transmission;regulation of primary metabolic process;negative regulation of epithelial cell proliferation;anion transport;calcium ion homeostasis;positive regulation of cholesterol esterification;regulation of extent of cell growth;signal transduction by protein phosphorylation;dendritic spine organization;dendritic spine maintenance;positive regulation of macromolecule metabolic process;cellular macromolecule localization;cell projection morphogenesis;response to wounding;interspecies interaction between organisms;negative regulation of lipid metabolic process;positive regulation of lipid metabolic process;platelet activation;epithelial cell proliferation;cytoskeleton organization;cellular homeostasis;vitamin metabolic process;regulation of macromolecule metabolic process;regulation of Ras protein signal transduction;negative regulation of cholesterol efflux;regulation of proteolysis;protein catabolic process;regulation of neuron projection development;regulation of cholesterol esterification;regulation of axon extension;lipid localization;regulation of cholesterol efflux;positive regulation of cholesterol efflux;cell motility;chemical homeostasis;purine nucleotide metabolic process;triglyceride catabolic process;purine nucleotide biosynthetic process;regulation of blood coagulation;aromatic compound biosynthetic process;negative regulation of blood coagulation;positive regulation of anion transport;negative regulation of anion transport;cell morphogenesis involved in neuron differentiation;regulation of cholesterol metabolic process;cGMP-mediated signaling;cyclic-nucleotide-mediated signaling;second-messenger-mediated signaling;macromolecule catabolic process;positive regulation of oxidoreductase activity;organic substance biosynthetic process;organic substance catabolic process;cell growth;regulation of cellular protein catabolic process;heterocycle metabolic process;cellular component organization;lipid catabolic process;macromolecular complex assembly;negative regulation of platelet activation;biological regulation;regulation of platelet activation;protein-lipid complex assembly;negative regulation of alcohol biosynthetic process;positive regulation of receptor catabolic process;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;blood circulation;purine ribonucleotide biosynthetic process;wound healing;purine ribonucleotide metabolic process;protein modification process;biological_process;metabolic process;cholesterol homeostasis;regulation of cGMP biosynthetic process;positive regulation of protein catabolic process;triglyceride-rich lipoprotein particle remodeling;synapse organization;lipid transport;regulation of synapse structure or activity;phosphorylation;ion homeostasis;metal ion homeostasis;regulation of synapse organization;cholesterol transport;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;positive regulation of sterol transport;cellular macromolecule biosynthetic process;regulation of signaling;ameboidal-type cell migration;anatomical structure morphogenesis;Ras protein signal transduction;positive regulation of catalytic activity;divalent inorganic cation homeostasis;cellular divalent inorganic cation homeostasis;establishment of localization in cell;regulation of beta-amyloid clearance;acylglycerol catabolic process;regulation of cGMP metabolic process;neutral lipid catabolic process;primary metabolic process;alcohol biosynthetic process;protein import;positive regulation of cGMP metabolic process;regulation of response to stimulus;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of protein serine/threonine kinase activity;cation homeostasis;anion homeostasis;cellular chemical homeostasis;steroid metabolic process;cholesterol metabolic process;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;positive regulation of developmental process;macromolecule metabolic process;positive regulation of steroid metabolic process;glutamate receptor clustering;positive regulation of proteolysis;reverse cholesterol transport;response to extracellular stimulus;regulation of cellular catabolic process;vasculature development;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of cell death;regulation of cell death;protein-lipid complex subunit organization;plasma lipoprotein particle organization;growth;regulation of growth;gene expression;isoprenoid metabolic process;regulation of gene expression;neuron development;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;neuron apoptotic process;cellular macromolecule catabolic process;cell communication;generation of neurons;regulation of purine nucleotide metabolic process;cell part morphogenesis;nervous system development;endothelial cell proliferation;positive regulation of cGMP biosynthetic process;regulation of cellular component biogenesis;cholesterol efflux;viral process;organophosphate ester transport;protein transport;negative regulation of protein phosphorylation;regulation of protein phosphorylation;artery development;modification of morphology or physiology of other organism;negative regulation of endothelial cell proliferation;positive regulation of cellular component biogenesis; 6;6;4;5;4;6;4;5;5;7;5;5;6;4;3;3;5;4;7;7;5;5;4;7;5;5;5;7;7;6;4;4;4;5;4;4;3;3;4;5;5;4;5;5;5;8;2;4;5;5;6;3;4;5;5;4;7;5;9;9;5;6;8;6;4;5;3;5;4;5;4;6;4;4;5;5;5;6;3;6;3;5;4;4;4;3;8;9;6;5;4;7;6;5;4;5;4;6;5;5;7;4;6;4;6;5;5;5;9;4;4;5;4;7;5;6;5;5;3;6;7;8;8;6;5;5;6;6;3;4;3;3;5;2;4;4;3;5;5;3;9;3;5;5;5;4;4;4;5;5;3;3;3;6;4;5;4;6;6;4;5;5;5;5;5;5;4;3;4;5;7;5;8;4;7;5;6;4;4;3;4;6;6;5;3;3;6;4;7;7;6;5;4;4;2;5;7;6;6;6;4;6;6;5;6;5;3;7;5;5;4;4;5;4;5;7;6;4;6;5;5;3;4;5;4;4;3;7;4;3;5;5;5;5;7;6;5;6;5;4;6;2;4;6;5;4;4;5;4;6;4;5;5;4;5;4;4;4;6;5;7;7;4;5;6;2;6;6;5;6;5;3;3;4;5;5;5;6;6;6;5;4;7;6;6;5;8;4;3;5;5;4;4;4;4;5;4;6;5;7;4;7;5;7;4;7;4;4;5;5;6;6;6;7;6;6;5;6;6;5;6;6;5;6;6;5;6;8;4;3;6;6;7;4;5;4;3;4;7;3;6;6;6;4;6;6;3;4;8;3;4;8;5;5;6;2;5;4;4;4;5;4;4;5;5;2;2;6;4;7;6;6;5;6;6;8;3;3;4;5;3;4;4;8;4;4;6;6;4;5;5;5;6;4;4;3;5;2;7;6;5;7;6;4;4;4;4;7;5;6;6;5;4;5;4;5;3;4;6;5;5;4;5;4;4;3;3;5;4;4;5;3;6;5;5;5;6;5;6;6;6;5;5;5;6;6;6;7;6;5;8;5;6;6;6;6;7;6;6;4;5;5;4;5;5;5;7;5;4;2;2;7;6;5;2;4;7;7;5;3;5;7;5;6;6;4;6;5;7;6;6;6;5;6;5;5;4;3;6;7;8;5;5;5;5;6;3;5;6;4;4;4;3;2;3;3;6;6;4;5;5;6;4;4;5;6;9;5;5;4;5;5;4;4;5;4;3;4;4;5;4;5;4;5;4;7;7;6;5;6;5;5;4;8;7;3;5;6;8;7;5;5;5;5;5;6;7;8;7;6;5;4;4;4;3;6;4;3;5;5;5;2;5;6;5;5;3;3;4;5;8;5;7;5;1;2;8;8;5;5;4;5;4;6;6;8;5;7;4;4;4;2;5;5;3;5;3;7;5;8;8;4;4;7;8;6;3;6;5;8;3;4;4;4;9;7;7;5;5;7;3;5;5;5;3;4;5;6;6;8;4;5;5;5;4;4;4;4;4;5;4;2;3;5;5;5;5;4;4;5;6;6;5;4;7;7;5;5;5;8;3;8;4;5;5;7;7;5;3;6;3; GO:0034358;GO:0044424;GO:0044421;GO:0044422;GO:0043025;GO:0005773;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0005769;GO:0071682;GO:0016023;GO:0034361;GO:0034363;GO:0034364;GO:0044297;GO:0042995;GO:0043230;GO:0043231;GO:0043233;GO:0072562;GO:0044433;GO:0034385;GO:1990777;GO:0060205;GO:0005768;GO:0005783;GO:0031974;GO:0036477;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0042627;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0016020;GO:0031012;GO:0005634;GO:0043005;GO:0034362;GO:0030425;GO:0031983;GO:0031988;GO:0005794;GO:0005737;GO:0097708;GO:0031410;GO:0005623;GO:0030139;GO:0097458;GO:0005576;GO:0005886;GO:1903561;GO:0032994;GO:0032991;GO:0005575; plasma lipoprotein particle;intracellular part;extracellular region part;organelle part;neuronal cell body;vacuole;cell part;cell periphery;extracellular space;extracellular exosome;early endosome;endocytic vesicle lumen;cytoplasmic, membrane-bounded vesicle;very-low-density lipoprotein particle;intermediate-density lipoprotein particle;high-density lipoprotein particle;cell body;cell projection;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;blood microparticle;cytoplasmic vesicle part;triglyceride-rich lipoprotein particle;lipoprotein particle;cytoplasmic membrane-bounded vesicle lumen;endosome;endoplasmic reticulum;membrane-enclosed lumen;somatodendritic compartment;intracellular organelle;intracellular;membrane-bounded organelle;organelle;chylomicron;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;membrane;extracellular matrix;nucleus;neuron projection;low-density lipoprotein particle;dendrite;vesicle lumen;membrane-bounded vesicle;Golgi apparatus;cytoplasm;intracellular vesicle;cytoplasmic vesicle;cell;endocytic vesicle;neuron part;extracellular region;plasma membrane;extracellular vesicle;protein-lipid complex;macromolecular complex;cellular_component; 3;3;2;2;4;5;2;3;3;4;5;6;5;5;5;4;3;3;3;4;3;3;4;4;4;5;4;4;2;4;3;3;3;2;4;3;4;3;4;2;2;5;4;4;5;4;5;4;4;4;5;2;6;3;2;3;3;3;2;1; GO:0071814;GO:0005488;GO:0048156;GO:1901681;GO:0008289;GO:0046872;GO:0017127;GO:0043167;GO:0046983;GO:0005543;GO:0005319;GO:0016209;GO:0022892;GO:0005215;GO:0005515;GO:0005102;GO:0008047;GO:0033218;GO:0098772;GO:0043178;GO:0003674;GO:0097159;GO:0043168;GO:0042277;GO:0042802;GO:0042803;GO:0071813;GO:0008092;GO:0032934;GO:0030234;GO:0036094;GO:0050750;GO:0005496;GO:0044877;GO:0015485;GO:0097367;GO:0046911;GO:0015248;GO:0043169;GO:0005539;GO:0001540;GO:0008201;GO:0060228;GO:0070325;GO:0070326; protein-lipid complex binding;binding;tau protein binding;sulfur compound binding;lipid binding;metal ion binding;cholesterol transporter activity;ion binding;protein dimerization activity;phospholipid binding;lipid transporter activity;antioxidant activity;substrate-specific transporter activity;transporter activity;protein binding;receptor binding;enzyme activator activity;amide binding;molecular function regulator;alcohol binding;molecular_function;organic cyclic compound binding;anion binding;peptide binding;identical protein binding;protein homodimerization activity;lipoprotein particle binding;cytoskeletal protein binding;sterol binding;enzyme regulator activity;small molecule binding;low-density lipoprotein particle receptor binding;steroid binding;macromolecular complex binding;cholesterol binding;carbohydrate derivative binding;metal chelating activity;sterol transporter activity;cation binding;glycosaminoglycan binding;beta-amyloid binding;heparin binding;phosphatidylcholine-sterol O-acyltransferase activator activity;lipoprotein particle receptor binding;very-low-density lipoprotein particle receptor binding; 4;2;5;3;3;5;6;3;4;4;4;2;3;2;3;4;4;3;2;4;1;3;4;4;4;5;5;4;5;3;3;6;4;3;6;3;6;5;4;4;5;4;5;5;6; K04524 map05010; Alzheimer's disease; IPR000074; Apolipoprotein A/E; extracellular P01705 Immunoglobulin lambda variable 2-23 OS=Homo sapiens OX=9606 GN=IGLV2-23 PE=1 SV=2 - [LV223_HUMAN] 1.636 0.642 0.866 1.43 0.594 1.245 2.548286604 nan 2.407407407 nan 1.348909657 nan 2.095959596 nan GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q5T7W0 Zinc finger protein 618 OS=Homo sapiens OX=9606 GN=ZNF618 PE=1 SV=1 - [ZN618_HUMAN] 0.519 0.572 2.679 0.482 0.688 0.387 0.907342657 nan 0.700581395 nan 4.683566434 nan 0.5625 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; IPR013087;IPR012337; Zinc finger C2H2-type;Ribonuclease H-like domain; nucleus Hs18572895 1130.0 L [L] Replication, recombination and repair; P62328 Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2 - [TYB4_HUMAN] 0.886 1 1.294 1.127 0.623 0.882 0.886 0.811167247 1.808988764 0.168469174 1.294 0.580573416 1.415730337 0.314513379 GO:0008104;GO:0008064;GO:0001503;GO:0051651;GO:0071840;GO:0070727;GO:0048869;GO:0051494;GO:0051493;GO:0048519;GO:0033036;GO:0045185;GO:0030041;GO:0065008;GO:0048870;GO:0010639;GO:0031333;GO:0032535;GO:0022607;GO:0006928;GO:0042989;GO:0016043;GO:0090066;GO:0065003;GO:0065007;GO:0016477;GO:0034613;GO:0050794;GO:0008154;GO:0008150;GO:0032956;GO:0051235;GO:2000145;GO:0033043;GO:0030154;GO:0051129;GO:0051128;GO:0043254;GO:0044699;GO:0032271;GO:0032272;GO:0032502;GO:0006996;GO:0032501;GO:0032507;GO:0032970;GO:0051270;GO:0032879;GO:0044707;GO:0051258;GO:0051674;GO:0009987;GO:0043933;GO:0030036;GO:0034622;GO:0001649;GO:0030832;GO:0030833;GO:0071822;GO:0030837;GO:0050789;GO:0070271;GO:0030334;GO:0030029;GO:0006461;GO:0044767;GO:0044763;GO:0043623;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0007015;GO:0040012;GO:0007010;GO:0044087;GO:1902589;GO:0044085;GO:0048523; protein localization;regulation of actin polymerization or depolymerization;ossification;maintenance of location in cell;cellular component organization or biogenesis;cellular macromolecule localization;cellular developmental process;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;negative regulation of biological process;macromolecule localization;maintenance of protein location;actin filament polymerization;regulation of biological quality;cell motility;negative regulation of organelle organization;negative regulation of protein complex assembly;regulation of cellular component size;cellular component assembly;movement of cell or subcellular component;sequestering of actin monomers;cellular component organization;regulation of anatomical structure size;macromolecular complex assembly;biological regulation;cell migration;cellular protein localization;regulation of cellular process;actin polymerization or depolymerization;biological_process;regulation of actin cytoskeleton organization;maintenance of location;regulation of cell motility;regulation of organelle organization;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein complex assembly;single-organism process;regulation of protein polymerization;negative regulation of protein polymerization;developmental process;organelle organization;multicellular organismal process;maintenance of protein location in cell;regulation of actin filament-based process;regulation of cellular component movement;regulation of localization;single-multicellular organism process;protein polymerization;localization of cell;cellular process;macromolecular complex subunit organization;actin cytoskeleton organization;cellular macromolecular complex assembly;osteoblast differentiation;regulation of actin filament length;regulation of actin filament polymerization;protein complex subunit organization;negative regulation of actin filament polymerization;regulation of biological process;protein complex biogenesis;regulation of cell migration;actin filament-based process;protein complex assembly;single-organism developmental process;single-organism cellular process;cellular protein complex assembly;localization;single-organism localization;cellular localization;locomotion;actin filament organization;regulation of locomotion;cytoskeleton organization;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;negative regulation of cellular process; 4;6;4;4;2;4;4;6;6;2;3;4;8;3;3;5;5;4;4;4;6;3;4;5;2;4;5;3;7;1;5;3;4;5;5;4;4;4;2;5;6;2;4;2;5;4;4;3;3;7;3;2;4;5;6;5;5;6;5;7;2;4;5;4;5;3;3;6;2;3;3;2;6;3;5;3;4;3;3; GO:0043231;GO:0043232;GO:0005829;GO:0044424;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575; intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoplasmic part;cytoplasm;nucleus;cell part;cell;intracellular;cellular_component; 4;4;5;3;3;3;3;2;5;4;4;5;2;2;3;1; GO:1901363;GO:0005488;GO:0003676;GO:0097159;GO:0044822;GO:0003723;GO:0003674; heterocyclic compound binding;binding;nucleic acid binding;organic cyclic compound binding;poly(A) RNA binding;RNA binding;molecular_function; 3;2;4;3;6;5;1; K05764 map04810; Regulation of actin cytoskeleton; IPR001152; Beta-thymosin; nucleus Hs11056061 85.5 N [N] Cell motility; P01703 Immunoglobulin lambda variable 1-40 OS=Homo sapiens OX=9606 GN=IGLV1-40 PE=1 SV=2 - [LV140_HUMAN] 1.414 0.887 0.973 1.092 0.829 0.942 1.594137542 nan 1.317249698 nan 1.096956032 nan 1.136308806 nan GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P01700 Immunoglobulin lambda variable 1-47 OS=Homo sapiens OX=9606 GN=IGLV1-47 PE=1 SV=2 - [LV147_HUMAN] 0.988 1.068 1.003 0.947 1.052 1.057 0.925093633 0.145573501 0.900190114 0.045341597 0.939138577 0.222345991 1.004752852 0.089347397 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P01701 Immunoglobulin lambda variable 1-51 OS=Homo sapiens OX=9606 GN=IGLV1-51 PE=1 SV=2 - [LV151_HUMAN] 0.834 0.774 1.585 0.913 0.72 1.162 1.07751938 0.259034467 1.268055556 0.01694306 2.047803618 0.000109991 1.613888889 0.000590455 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P01706 Immunoglobulin lambda variable 2-11 OS=Homo sapiens OX=9606 GN=IGLV2-11 PE=1 SV=2 - [LV211_HUMAN] 1.359 0.805 0.911 1.209 0.865 1.165 1.688198758 2.63E-06 1.397687861 0.008691028 1.131677019 0.000885187 1.346820809 0.059944819 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9Y5R5 Doublesex- and mab-3-related transcription factor 2 OS=Homo sapiens OX=9606 GN=DMRT2 PE=2 SV=2 - [DMRT2_HUMAN] 0.9 0.78 0.999 1.053 0.893 3.014 1.153846154 nan 1.179171333 nan 1.280769231 nan 3.375139978 nan GO:0080090;GO:0019222;GO:0001501;GO:1901362;GO:1901360;GO:0000003;GO:0048518;GO:1902680;GO:0060255;GO:0003006;GO:0003002;GO:0045995;GO:2001141;GO:0001756;GO:0046483;GO:0044707;GO:0009790;GO:0019438;GO:0009893;GO:0022603;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0048646;GO:0018130;GO:0048706;GO:0014807;GO:0050793;GO:0009889;GO:0009888;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0010604;GO:0016070;GO:0007548;GO:0044271;GO:0009952;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0009792;GO:0034645;GO:0009653;GO:0044699;GO:0006139;GO:0051240;GO:0009891;GO:0043009;GO:0032502;GO:0032501;GO:0060429;GO:0006725;GO:1903506;GO:0045893;GO:0061055;GO:0061053;GO:0051094;GO:2000287;GO:0051252;GO:0051254;GO:0043170;GO:0051239;GO:0040019;GO:0010628;GO:0045944;GO:0048731;GO:1903508;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0035282;GO:0007275;GO:0007389;GO:2000112;GO:2000290;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0009987;GO:0045935;GO:0019219;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044238;GO:0048856;GO:0044237;GO:2000026;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;skeletal system development;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;reproduction;positive regulation of biological process;positive regulation of RNA biosynthetic process;regulation of macromolecule metabolic process;developmental process involved in reproduction;regionalization;regulation of embryonic development;regulation of RNA biosynthetic process;somitogenesis;heterocycle metabolic process;single-multicellular organism process;embryo development;aromatic compound biosynthetic process;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;embryonic skeletal system development;regulation of somitogenesis;regulation of developmental process;regulation of biosynthetic process;tissue development;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of macromolecule metabolic process;RNA metabolic process;sex differentiation;cellular nitrogen compound biosynthetic process;anterior/posterior pattern specification;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;positive regulation of multicellular organismal process;positive regulation of biosynthetic process;chordate embryonic development;developmental process;multicellular organismal process;epithelium development;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;myotome development;somite development;positive regulation of developmental process;positive regulation of myotome development;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;regulation of multicellular organismal process;positive regulation of embryonic development;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;system development;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;segmentation;multicellular organism development;pattern specification process;regulation of cellular macromolecule biosynthetic process;regulation of myotome development;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;cellular process;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of multicellular organismal development;positive regulation of cellular process; 4;3;5;5;4;2;2;6;4;3;5;5;6;4;4;3;5;5;3;4;3;2;7;4;4;2;7;3;5;6;5;3;4;4;3;1;2;5;4;5;4;5;6;6;5;7;6;6;4;4;6;5;3;2;4;3;4;7;2;2;5;4;7;6;4;6;3;5;5;5;4;3;4;5;7;4;7;5;5;4;4;5;6;4;4;6;5;3;5;5;5;2;5;5;3;2;3;5;4;4;3;3;3;4;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;nucleus;cell part;cell;organelle;cellular_component; 4;3;3;3;3;5;2;2;2;1; GO:0043169;GO:0001071;GO:1901363;GO:0046872;GO:0001067;GO:0044212;GO:0001012;GO:0001159;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000987;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:0046983;GO:1990837;GO:0043167;GO:0042802;GO:0042803;GO:0003690;GO:0005515;GO:0000977;GO:0003700; cation binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;metal ion binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter proximal region sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;protein dimerization activity;sequence-specific double-stranded DNA binding;ion binding;identical protein binding;protein homodimerization activity;double-stranded DNA binding;protein binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 4;2;3;5;5;7;8;8;1;2;4;5;9;6;3;8;6;4;7;3;4;5;6;3;9;3; K19489 IPR001275;IPR026607; DM DNA-binding domain;DMRT/protein doublesex/protein male abnormal 3; nucleus Hs5729806 429.0 K [K] Transcription; P02042 Hemoglobin subunit delta OS=Homo sapiens OX=9606 GN=HBD PE=1 SV=2 - [HBD_HUMAN] 0.848 1.064 1.1 1.028 1.008 1.147 0.796992481 0.000380681 1.01984127 0.699120562 1.033834586 0.310754833 1.137896825 0.270269408 GO:0007599;GO:0007596;GO:0044699;GO:0050878;GO:0009611;GO:0065007;GO:0065008;GO:0032501;GO:0042060;GO:0006950;GO:0008150;GO:0044707;GO:0050817;GO:0050896; hemostasis;blood coagulation;single-organism process;regulation of body fluid levels;response to wounding;biological regulation;regulation of biological quality;multicellular organismal process;wound healing;response to stress;biological_process;single-multicellular organism process;coagulation;response to stimulus; 5;5;2;4;4;2;3;2;5;3;1;3;4;2; GO:0005833;GO:0005737;GO:0044445;GO:0072562;GO:0044421;GO:0005576;GO:0005615;GO:0043234;GO:0032991;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; hemoglobin complex;cytoplasm;cytosolic part;blood microparticle;extracellular region part;extracellular region;extracellular space;protein complex;macromolecular complex;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 4;4;5;3;2;2;3;3;2;5;2;2;3;1;4;3; GO:0005344;GO:0046872;GO:0003674;GO:0005488;GO:1901363;GO:0043169;GO:0046914;GO:0043167;GO:0005506;GO:0020037;GO:0005215;GO:0019825;GO:0022892;GO:0046906;GO:0097159; oxygen transporter activity;metal ion binding;molecular_function;binding;heterocyclic compound binding;cation binding;transition metal ion binding;ion binding;iron ion binding;heme binding;transporter activity;oxygen binding;substrate-specific transporter activity;tetrapyrrole binding;organic cyclic compound binding; 4;5;1;2;3;4;6;3;7;5;2;3;3;4;3; K16151 IPR002337;IPR000971;IPR009050; Haemoglobin, beta-type;Globin;Globin-like; cytosol Hs4504351 303.0 C [C] Energy production and conversion; O60477 BMP/retinoic acid-inducible neural-specific protein 1 OS=Homo sapiens OX=9606 GN=BRINP1 PE=1 SV=2 - [BRNP1_HUMAN] 1.031 1.13 0.861 0.955 1.078 1.563 0.912389381 nan 0.885899814 nan 0.761946903 nan 1.449907236 nan GO:0048856;GO:0030154;GO:0048468;GO:0007275;GO:0071229;GO:0022402;GO:0045597;GO:0070887;GO:0008219;GO:0050789;GO:0044699;GO:0050767;GO:0007346;GO:0045786;GO:0051962;GO:0033993;GO:0051240;GO:2000026;GO:0060284;GO:0050769;GO:0045664;GO:0071310;GO:0045666;GO:0065007;GO:0007049;GO:0010720;GO:0048518;GO:0048519;GO:0032502;GO:0045930;GO:0032526;GO:0032501;GO:0000278;GO:0030182;GO:0050793;GO:0009987;GO:0071396;GO:0051716;GO:0050794;GO:0007050;GO:0045595;GO:0044763;GO:0001101;GO:0051239;GO:0048731;GO:0042221;GO:0022008;GO:0010033;GO:1901700;GO:1901701;GO:0048699;GO:0007399;GO:0044707;GO:0051726;GO:0050896;GO:0051094;GO:0071300;GO:0051960;GO:0044767;GO:0048869;GO:0008150;GO:0048523;GO:0048522; anatomical structure development;cell differentiation;cell development;multicellular organism development;cellular response to acid chemical;cell cycle process;positive regulation of cell differentiation;cellular response to chemical stimulus;cell death;regulation of biological process;single-organism process;regulation of neurogenesis;regulation of mitotic cell cycle;negative regulation of cell cycle;positive regulation of nervous system development;response to lipid;positive regulation of multicellular organismal process;regulation of multicellular organismal development;regulation of cell development;positive regulation of neurogenesis;regulation of neuron differentiation;cellular response to organic substance;positive regulation of neuron differentiation;biological regulation;cell cycle;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;developmental process;negative regulation of mitotic cell cycle;response to retinoic acid;multicellular organismal process;mitotic cell cycle;neuron differentiation;regulation of developmental process;cellular process;cellular response to lipid;cellular response to stimulus;regulation of cellular process;cell cycle arrest;regulation of cell differentiation;single-organism cellular process;response to acid chemical;regulation of multicellular organismal process;system development;response to chemical;neurogenesis;response to organic substance;response to oxygen-containing compound;cellular response to oxygen-containing compound;generation of neurons;nervous system development;single-multicellular organism process;regulation of cell cycle;response to stimulus;positive regulation of developmental process;cellular response to retinoic acid;regulation of nervous system development;single-organism developmental process;cellular developmental process;biological_process;negative regulation of cellular process;positive regulation of cellular process; 3;5;4;4;5;4;4;4;4;2;2;6;5;4;4;5;3;4;5;5;7;5;6;2;4;5;2;2;2;5;5;2;5;6;3;2;6;3;3;5;4;3;4;3;4;3;6;4;4;5;7;5;3;4;2;3;6;5;3;4;1;3;3; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; IPR033237;IPR020864; BMP/retinoic acid-inducible neural-specific protein;Membrane attack complex component/perforin (MACPF) domain; extracellular Q16363 Laminin subunit alpha-4 OS=Homo sapiens OX=9606 GN=LAMA4 PE=1 SV=4 - [LAMA4_HUMAN] 0.69 0.722 1.989 0.619 0.846 1.212 0.95567867 0.15059803 0.731678487 0.00584959 2.754847645 0.014149361 1.432624113 5.30E-06 GO:0045995;GO:0030155;GO:0009790;GO:0051674;GO:0016477;GO:0050789;GO:0044699;GO:0032879;GO:0006928;GO:0016043;GO:0040012;GO:0030198;GO:0065007;GO:0071840;GO:0043062;GO:2000026;GO:0022610;GO:0032502;GO:0030334;GO:0050793;GO:0032501;GO:0009987;GO:0050794;GO:0044767;GO:0051270;GO:0008150;GO:0051239;GO:0007155;GO:0051179;GO:0040011;GO:0044707;GO:0048870;GO:0048856;GO:2000145;GO:0007275;GO:0044763; regulation of embryonic development;regulation of cell adhesion;embryo development;localization of cell;cell migration;regulation of biological process;single-organism process;regulation of localization;movement of cell or subcellular component;cellular component organization;regulation of locomotion;extracellular matrix organization;biological regulation;cellular component organization or biogenesis;extracellular structure organization;regulation of multicellular organismal development;biological adhesion;developmental process;regulation of cell migration;regulation of developmental process;multicellular organismal process;cellular process;regulation of cellular process;single-organism developmental process;regulation of cellular component movement;biological_process;regulation of multicellular organismal process;cell adhesion;localization;locomotion;single-multicellular organism process;cell motility;anatomical structure development;regulation of cell motility;multicellular organism development;single-organism cellular process; 5;4;5;3;4;2;2;3;4;3;3;5;2;2;4;4;2;2;5;3;2;2;3;3;4;1;3;3;2;2;3;3;3;4;4;3; GO:0031012;GO:0043227;GO:0070062;GO:0043226;GO:1903561;GO:0031982;GO:0005605;GO:0005604;GO:0043230;GO:0005578;GO:0005575;GO:0005576;GO:0044420;GO:0044421; extracellular matrix;membrane-bounded organelle;extracellular exosome;organelle;extracellular vesicle;vesicle;basal lamina;basement membrane;extracellular organelle;proteinaceous extracellular matrix;cellular_component;extracellular region;extracellular matrix component;extracellular region part; 2;3;4;2;3;4;3;3;3;3;1;2;2;2; GO:0005201;GO:0003674;GO:0005198; extracellular matrix structural constituent;molecular_function;structural molecule activity; 3;1;2; K06241 map04151;map04510;map04512;map05143;map05145;map05146;map05200;map05222; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;African trypanosomiasis;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer; IPR013320;IPR009254;IPR010307;IPR000742;IPR001791;IPR002049; Concanavalin A-like lectin/glucanase domain;Laminin alpha, domain I;Laminin domain II;EGF-like domain;Laminin G domain;Laminin EGF domain; extracellular Hs4504949 3773.0 W [W] Extracellular structures; O60573 Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1 - [IF4E2_HUMAN] 1.243 0.813 1.008 1.434 1.037 nan 1.528905289 nan 1.382835101 nan 1.239852399 nan nan nan GO:0019221;GO:0019222;GO:0007165;GO:0007166;GO:0080090;GO:0051716;GO:0010605;GO:0010608;GO:0043043;GO:0010467;GO:0048519;GO:0060255;GO:0032268;GO:0010033;GO:0044700;GO:1901564;GO:1901566;GO:0044707;GO:0044249;GO:0019538;GO:0009892;GO:0034645;GO:0009890;GO:0010629;GO:0006807;GO:0043170;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0034097;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0044271;GO:0071345;GO:0050896;GO:0010556;GO:0006518;GO:0010558;GO:0009790;GO:0034641;GO:0009792;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0051248;GO:0001701;GO:0051246;GO:0043009;GO:0032502;GO:0032501;GO:0034249;GO:0034248;GO:0043604;GO:0032269;GO:0043603;GO:0017148;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0007275;GO:2000112;GO:2000113;GO:0071704;GO:0071310;GO:0010468;GO:0009987;GO:1901576;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007154;GO:0044238;GO:0048856;GO:0044237;GO:0006417;GO:0006412;GO:0048523; cytokine-mediated signaling pathway;regulation of metabolic process;signal transduction;cell surface receptor signaling pathway;regulation of primary metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;posttranscriptional regulation of gene expression;peptide biosynthetic process;gene expression;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of cellular protein metabolic process;response to organic substance;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;single-multicellular organism process;cellular biosynthetic process;protein metabolic process;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;negative regulation of gene expression;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;response to cytokine;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;regulation of macromolecule biosynthetic process;peptide metabolic process;negative regulation of macromolecule biosynthetic process;embryo development;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;negative regulation of protein metabolic process;in utero embryonic development;regulation of protein metabolic process;chordate embryonic development;developmental process;multicellular organismal process;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;amide biosynthetic process;negative regulation of cellular protein metabolic process;cellular amide metabolic process;negative regulation of translation;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;multicellular organism development;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;regulation of gene expression;cellular process;organic substance biosynthetic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell communication;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of translation;translation;negative regulation of cellular process; 6;3;4;5;4;3;4;6;6;5;2;4;5;4;3;4;5;3;4;4;3;5;4;5;3;4;2;5;4;2;5;4;3;1;2;5;6;2;5;5;5;5;4;6;2;4;3;2;5;8;5;7;2;2;5;5;6;5;5;6;5;5;4;4;4;6;6;3;5;5;2;4;3;3;5;3;4;4;4;3;3;3;6;6;3; GO:0034518;GO:0043234;GO:0005829;GO:0044424;GO:0005845;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0032991;GO:0005575; RNA cap binding complex;protein complex;cytosol;intracellular part;mRNA cap binding complex;cytoplasmic part;cytoplasm;cell part;cell;intracellular;macromolecular complex;cellular_component; 4;3;5;3;4;4;4;2;2;3;2;1; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0000339;GO:0097159;GO:0003743;GO:0019899;GO:0044822;GO:0008135;GO:0031625;GO:0003723;GO:0005515;GO:0044389; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;RNA cap binding;organic cyclic compound binding;translation initiation factor activity;enzyme binding;poly(A) RNA binding;translation factor activity, RNA binding;ubiquitin protein ligase binding;RNA binding;protein binding;ubiquitin-like protein ligase binding; 3;1;2;4;6;3;7;4;6;6;6;5;3;5; K03259 map03013;map04066;map04150;map04151;map04211;map04910; RNA transport;HIF-1 signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Longevity regulating pathway;Insulin signaling pathway; IPR023398;IPR019770;IPR001040; Translation Initiation factor eIF- 4e-like;Eukaryotic translation initiation factor 4E (eIF-4E), conserved site;Translation Initiation factor eIF- 4e; cytosol Hs4757702 516.0 J [J] Translation, ribosomal structure and biogenesis; P01709 Immunoglobulin lambda variable 2-8 OS=Homo sapiens OX=9606 GN=IGLV2-8 PE=1 SV=2 - [LV208_HUMAN] 1.326 0.827 0.753 1.392 0.942 0.888 1.603385732 9.15E-05 1.477707006 0.00038953 0.910519952 0.332664141 0.942675159 0.909999275 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P02741 C-reactive protein OS=Homo sapiens OX=9606 GN=CRP PE=1 SV=1 - [CRP_HUMAN] 0.816 0.624 1.629 0.939 0.574 1.754 1.307692308 0.002564853 1.635888502 1.36E-07 2.610576923 1.09E-06 3.055749129 0.000913245 GO:0008104;GO:0006909;GO:0019222;GO:0032928;GO:0051049;GO:0045908;GO:0003013;GO:0019915;GO:0003018;GO:0043207;GO:0009617;GO:0048518;GO:0048519;GO:0033036;GO:0051093;GO:0032930;GO:0060255;GO:2000482;GO:0045184;GO:0050830;GO:0009607;GO:0010876;GO:0003008;GO:0016192;GO:0044707;GO:0090077;GO:0010468;GO:0002376;GO:0010883;GO:0010888;GO:0009893;GO:0032940;GO:0010628;GO:0006801;GO:0042311;GO:0042312;GO:0051223;GO:0042554;GO:0050708;GO:0050707;GO:0090066;GO:0008015;GO:0065007;GO:0065008;GO:0035150;GO:0070201;GO:2000379;GO:0009306;GO:0006810;GO:2000377;GO:0050794;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:1903523;GO:0006954;GO:0002526;GO:0051235;GO:0051234;GO:0010604;GO:0044767;GO:0046903;GO:0006897;GO:0050896;GO:0008228;GO:0042742;GO:0051239;GO:0048869;GO:1903522;GO:0051046;GO:0008152;GO:0030154;GO:0090322;GO:1903530;GO:0044699;GO:0032880;GO:0050880;GO:0044057;GO:0051241;GO:0032677;GO:0032502;GO:0032501;GO:0009987;GO:0072593;GO:0045596;GO:0045595;GO:0098542;GO:0032879;GO:0051707;GO:0043170;GO:0001816;GO:0001817;GO:0060341;GO:0031325;GO:0072606;GO:0031323;GO:0050663;GO:0050789;GO:0071704;GO:0010467;GO:0071702;GO:0010745;GO:0051704;GO:0009605;GO:0010742;GO:0010743;GO:0032637;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0051641;GO:0050793;GO:0044237;GO:0002252;GO:0015031;GO:0048523;GO:0048522; protein localization;phagocytosis;regulation of metabolic process;regulation of superoxide anion generation;regulation of transport;negative regulation of vasodilation;circulatory system process;lipid storage;vascular process in circulatory system;response to external biotic stimulus;response to bacterium;positive regulation of biological process;negative regulation of biological process;macromolecule localization;negative regulation of developmental process;positive regulation of superoxide anion generation;regulation of macromolecule metabolic process;regulation of interleukin-8 secretion;establishment of protein localization;defense response to Gram-positive bacterium;response to biotic stimulus;lipid localization;system process;vesicle-mediated transport;single-multicellular organism process;foam cell differentiation;regulation of gene expression;immune system process;regulation of lipid storage;negative regulation of lipid storage;positive regulation of metabolic process;secretion by cell;positive regulation of gene expression;superoxide metabolic process;vasodilation;regulation of vasodilation;regulation of protein transport;superoxide anion generation;regulation of protein secretion;regulation of cytokine secretion;regulation of anatomical structure size;blood circulation;biological regulation;regulation of biological quality;regulation of tube size;regulation of establishment of protein localization;positive regulation of reactive oxygen species metabolic process;protein secretion;transport;regulation of reactive oxygen species metabolic process;regulation of cellular process;defense response;acute-phase response;response to stress;biological_process;negative regulation of blood circulation;inflammatory response;acute inflammatory response;maintenance of location;establishment of localization;positive regulation of macromolecule metabolic process;single-organism developmental process;secretion;endocytosis;response to stimulus;opsonization;defense response to bacterium;regulation of multicellular organismal process;cellular developmental process;regulation of blood circulation;regulation of secretion;metabolic process;cell differentiation;regulation of superoxide metabolic process;regulation of secretion by cell;single-organism process;regulation of protein localization;regulation of blood vessel size;regulation of system process;negative regulation of multicellular organismal process;regulation of interleukin-8 production;developmental process;multicellular organismal process;cellular process;reactive oxygen species metabolic process;negative regulation of cell differentiation;regulation of cell differentiation;defense response to other organism;regulation of localization;response to other organism;macromolecule metabolic process;cytokine production;regulation of cytokine production;regulation of cellular localization;positive regulation of cellular metabolic process;interleukin-8 secretion;regulation of cellular metabolic process;cytokine secretion;regulation of biological process;organic substance metabolic process;gene expression;organic substance transport;negative regulation of macrophage derived foam cell differentiation;multi-organism process;response to external stimulus;macrophage derived foam cell differentiation;regulation of macrophage derived foam cell differentiation;interleukin-8 production;single-organism transport;single-organism cellular process;localization;single-organism localization;cellular localization;regulation of developmental process;cellular metabolic process;immune effector process;protein transport;negative regulation of cellular process;positive regulation of cellular process; 4;5;3;7;4;5;4;4;5;4;4;2;2;3;3;6;4;6;4;6;3;4;3;5;3;6;5;2;4;3;3;4;5;5;7;6;5;6;6;5;4;5;2;3;5;5;5;5;4;5;3;4;7;3;1;4;5;6;3;3;4;3;5;6;2;4;5;3;4;5;5;2;5;6;5;2;4;6;4;3;5;2;2;2;4;4;4;4;3;3;4;4;4;4;4;6;4;5;2;3;5;5;5;2;3;7;5;5;4;3;2;3;3;3;3;3;5;3;3; GO:0031982;GO:0005615;GO:0043230;GO:0044421;GO:0043227;GO:0043226;GO:0070062;GO:1903561;GO:0005575;GO:0005576; vesicle;extracellular space;extracellular organelle;extracellular region part;membrane-bounded organelle;organelle;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;3;3;2;3;2;4;3;1;2; GO:0001848;GO:0003674;GO:0001849;GO:0001846;GO:0033265;GO:0043169;GO:0043167;GO:0005509;GO:0050750;GO:0071813;GO:0046872;GO:0071814;GO:0043178;GO:0005515;GO:0044877;GO:0005102;GO:0005488;GO:0050997;GO:0030169;GO:0070405;GO:0070325;GO:0036094; complement binding;molecular_function;complement component C1q binding;opsonin binding;choline binding;cation binding;ion binding;calcium ion binding;low-density lipoprotein particle receptor binding;lipoprotein particle binding;metal ion binding;protein-lipid complex binding;alcohol binding;protein binding;macromolecular complex binding;receptor binding;binding;quaternary ammonium group binding;low-density lipoprotein particle binding;ammonium ion binding;lipoprotein particle receptor binding;small molecule binding; 4;1;5;4;4;4;3;6;6;5;5;4;4;3;3;4;2;3;6;5;5;3; K16143 IPR001759;IPR013320;IPR030476; Pentraxin-related;Concanavalin A-like lectin/glucanase domain;Pentaxin, conserved site; extracellular 32471540 63.2 U [U] Intracellular trafficking, secretion, and vesicular transport; COG2911 Autotransporter translocation and assembly factor TamB Q8WUA7 TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2 - [TB22A_HUMAN] 0.974 1.029 0.699 0.985 1.286 1.986 0.946550049 nan 0.765940902 nan 0.679300292 nan 1.544323484 nan GO:0030234;GO:0005096;GO:0030695;GO:0003674;GO:0008047;GO:0005515;GO:0042803;GO:0046983;GO:0098772;GO:0060589;GO:0042802;GO:0005488; enzyme regulator activity;GTPase activator activity;GTPase regulator activity;molecular_function;enzyme activator activity;protein binding;protein homodimerization activity;protein dimerization activity;molecular function regulator;nucleoside-triphosphatase regulator activity;identical protein binding;binding; 3;5;5;1;4;3;5;4;2;4;4;2; K20360 IPR000195; Rab-GTPase-TBC domain; nucleus Hs18594431 1075.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q9UMS6 Synaptopodin-2 OS=Homo sapiens OX=9606 GN=SYNPO2 PE=1 SV=2 - [SYNP2_HUMAN] 2.13 0.791 0.269 1.243 0.992 0.541 2.692793932 nan 1.253024194 nan 0.340075853 nan 0.545362903 nan GO:0015629;GO:0030016;GO:0030017;GO:0043229;GO:0043228;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0030054;GO:0030055;GO:0005856;GO:0005634;GO:0031674;GO:0030018;GO:0005737;GO:0070161;GO:0043292;GO:0005912;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422;GO:0044449; actin cytoskeleton;myofibril;sarcomere;intracellular organelle;non-membrane-bounded organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;cell junction;cell-substrate junction;cytoskeleton;nucleus;I band;Z disc;cytoplasm;anchoring junction;contractile fiber;adherens junction;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part;contractile fiber part; 6;6;4;3;3;4;5;3;2;2;3;5;5;4;4;4;3;5;4;4;4;2;2;3;1;4;3;2;3; GO:0003674;GO:0005488;GO:0071889;GO:0042805;GO:0051393;GO:0008092;GO:0051371;GO:0005515; molecular_function;binding;14-3-3 protein binding;actinin binding;alpha-actinin binding;cytoskeletal protein binding;muscle alpha-actinin binding;protein binding; 1;2;4;5;6;4;7;3; IPR001478; PDZ domain; nucleus Q5JRV8 Transmembrane protein 255A OS=Homo sapiens OX=9606 GN=TMEM255A PE=2 SV=1 - [T255A_HUMAN] 1.159 1.396 0.636 0.979 1.121 0.917 0.830229226 nan 0.873327386 nan 0.455587393 nan 0.818019625 nan GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; IPR028014; FAM70 protein; plasma membrane P12273 Prolactin-inducible protein OS=Homo sapiens OX=9606 GN=PIP PE=1 SV=1 - [PIP_HUMAN] 0.84 1.015 1.005 1.024 1.336 0.959 0.827586207 nan 0.766467066 nan 0.990147783 nan 0.717814371 nan GO:0009593;GO:0019222;GO:0060249;GO:0070232;GO:0070233;GO:0070231;GO:0044707;GO:0001580;GO:0010467;GO:0048518;GO:0065007;GO:0070229;GO:0070228;GO:0060255;GO:0060548;GO:0007606;GO:0007600;GO:0070227;GO:0003008;GO:0048871;GO:0002376;GO:0019538;GO:0009893;GO:0010628;GO:0002682;GO:0065008;GO:0006810;GO:0050794;GO:0008150;GO:0008152;GO:0051234;GO:0010604;GO:0051606;GO:0012501;GO:0050896;GO:0044765;GO:0044699;GO:0006508;GO:0071887;GO:0032501;GO:0050877;GO:0009987;GO:0048519;GO:0001894;GO:0001895;GO:0055085;GO:0042592;GO:0043170;GO:0050906;GO:0050907;GO:0008219;GO:0010941;GO:0050909;GO:0042981;GO:0050789;GO:0071704;GO:0043067;GO:0043066;GO:0043069;GO:0010468;GO:0006915;GO:0050913;GO:0050912;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0044238;GO:2000107;GO:2000106;GO:0048523; detection of chemical stimulus;regulation of metabolic process;anatomical structure homeostasis;regulation of T cell apoptotic process;negative regulation of T cell apoptotic process;T cell apoptotic process;single-multicellular organism process;detection of chemical stimulus involved in sensory perception of bitter taste;gene expression;positive regulation of biological process;biological regulation;negative regulation of lymphocyte apoptotic process;regulation of lymphocyte apoptotic process;regulation of macromolecule metabolic process;negative regulation of cell death;sensory perception of chemical stimulus;sensory perception;lymphocyte apoptotic process;system process;multicellular organismal homeostasis;immune system process;protein metabolic process;positive regulation of metabolic process;positive regulation of gene expression;regulation of immune system process;regulation of biological quality;transport;regulation of cellular process;biological_process;metabolic process;establishment of localization;positive regulation of macromolecule metabolic process;detection of stimulus;programmed cell death;response to stimulus;single-organism transport;single-organism process;proteolysis;leukocyte apoptotic process;multicellular organismal process;neurological system process;cellular process;negative regulation of biological process;tissue homeostasis;retina homeostasis;transmembrane transport;homeostatic process;macromolecule metabolic process;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception;cell death;regulation of cell death;sensory perception of taste;regulation of apoptotic process;regulation of biological process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;regulation of gene expression;apoptotic process;sensory perception of bitter taste;detection of chemical stimulus involved in sensory perception of taste;single-organism cellular process;response to chemical;localization;single-organism localization;primary metabolic process;negative regulation of leukocyte apoptotic process;regulation of leukocyte apoptotic process;negative regulation of cellular process; 4;3;5;9;9;9;3;7;5;2;2;8;8;4;4;6;5;8;3;4;2;4;3;5;3;3;4;3;1;2;3;4;3;5;2;4;2;5;7;2;4;2;2;5;6;4;4;4;4;5;4;4;7;6;2;3;5;6;5;5;6;8;6;3;3;2;3;3;7;7;3; GO:0031982;GO:0016020;GO:0005576;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0098590;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005623;GO:0045177;GO:0005634;GO:0044459;GO:0016324;GO:0044464;GO:0071944;GO:0070062;GO:0098805;GO:0098589;GO:0005886;GO:1903561;GO:0005615;GO:0005575; vesicle;membrane;extracellular region;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;plasma membrane region;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cell;apical part of cell;nucleus;plasma membrane part;apical plasma membrane;cell part;cell periphery;extracellular exosome;whole membrane;membrane region;plasma membrane;extracellular vesicle;extracellular space;cellular_component; 4;2;2;3;4;3;2;2;4;3;3;3;2;2;3;5;3;4;2;3;4;3;3;3;3;3;1; GO:0070001;GO:0097367;GO:0003674;GO:0005488;GO:0003779;GO:0016787;GO:0003824;GO:0046983;GO:0008233;GO:0001948;GO:0032403;GO:0008092;GO:0019864;GO:0019865;GO:0004190;GO:0005515;GO:0044877;GO:0004175;GO:0070011; aspartic-type peptidase activity;carbohydrate derivative binding;molecular_function;binding;actin binding;hydrolase activity;catalytic activity;protein dimerization activity;peptidase activity;glycoprotein binding;protein complex binding;cytoskeletal protein binding;IgG binding;immunoglobulin binding;aspartic-type endopeptidase activity;protein binding;macromolecular complex binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;3;1;2;5;3;2;4;4;4;4;4;6;5;7;3;3;6;5; IPR007990;IPR013783;IPR014756; Prolactin-inducible protein;Immunoglobulin-like fold;Immunoglobulin E-set; extracellular Q9BZE7 UPF0193 protein EVG1 OS=Homo sapiens OX=9606 GN=C22orf23 PE=1 SV=1 - [EVG1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan IPR007914; Uncharacterised protein family UPF0193; nucleus Q9BTW9 Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2 - [TBCD_HUMAN] 0.625 0.639 2.155 0.843 0.748 0.747 0.978090767 nan 1.127005348 nan 3.372456964 nan 0.998663102 nan GO:0031110;GO:0031111;GO:0031113;GO:0031115;GO:0007162;GO:0071840;GO:0065003;GO:0051494;GO:0051493;GO:0044093;GO:0048519;GO:0031589;GO:0031109;GO:0019538;GO:0010639;GO:0070507;GO:0022607;GO:0006457;GO:0006458;GO:0050789;GO:0044267;GO:0043547;GO:0044260;GO:0043087;GO:0016043;GO:0070271;GO:0065007;GO:0065009;GO:0043085;GO:0050790;GO:0050794;GO:0008150;GO:0008152;GO:0043254;GO:0051336;GO:0033043;GO:0030155;GO:0051129;GO:0051128;GO:0007043;GO:0032886;GO:0044699;GO:0051084;GO:0034333;GO:0046785;GO:0032271;GO:0032272;GO:0022610;GO:0009987;GO:0045216;GO:0034329;GO:0051258;GO:0070830;GO:0043170;GO:0000226;GO:0043933;GO:0034332;GO:0034330;GO:0034622;GO:0007021;GO:0007023;GO:0071822;GO:0071704;GO:0031333;GO:0010810;GO:0010812;GO:0006461;GO:0044763;GO:0007155;GO:0043623;GO:0006996;GO:0044238;GO:0007017;GO:0007010;GO:0051345;GO:0044237;GO:0044087;GO:1902589;GO:0044085;GO:0043297;GO:0048523; regulation of microtubule polymerization or depolymerization;negative regulation of microtubule polymerization or depolymerization;regulation of microtubule polymerization;negative regulation of microtubule polymerization;negative regulation of cell adhesion;cellular component organization or biogenesis;macromolecular complex assembly;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;positive regulation of molecular function;negative regulation of biological process;cell-substrate adhesion;microtubule polymerization or depolymerization;protein metabolic process;negative regulation of organelle organization;regulation of microtubule cytoskeleton organization;cellular component assembly;protein folding;'de novo' protein folding;regulation of biological process;cellular protein metabolic process;positive regulation of GTPase activity;cellular macromolecule metabolic process;regulation of GTPase activity;cellular component organization;protein complex biogenesis;biological regulation;regulation of molecular function;positive regulation of catalytic activity;regulation of catalytic activity;regulation of cellular process;biological_process;metabolic process;regulation of protein complex assembly;regulation of hydrolase activity;regulation of organelle organization;regulation of cell adhesion;negative regulation of cellular component organization;regulation of cellular component organization;cell-cell junction assembly;regulation of microtubule-based process;single-organism process;'de novo' posttranslational protein folding;adherens junction assembly;microtubule polymerization;regulation of protein polymerization;negative regulation of protein polymerization;biological adhesion;cellular process;cell-cell junction organization;cell junction assembly;protein polymerization;bicellular tight junction assembly;macromolecule metabolic process;microtubule cytoskeleton organization;macromolecular complex subunit organization;adherens junction organization;cell junction organization;cellular macromolecular complex assembly;tubulin complex assembly;post-chaperonin tubulin folding pathway;protein complex subunit organization;organic substance metabolic process;negative regulation of protein complex assembly;regulation of cell-substrate adhesion;negative regulation of cell-substrate adhesion;protein complex assembly;single-organism cellular process;cell adhesion;cellular protein complex assembly;organelle organization;primary metabolic process;microtubule-based process;cytoskeleton organization;positive regulation of hydrolase activity;cellular metabolic process;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;apical junction assembly;negative regulation of cellular process; 6;7;6;7;4;2;5;6;6;4;2;4;6;4;5;5;4;3;4;2;5;7;4;6;3;4;2;3;5;4;3;1;2;4;5;5;4;4;4;6;4;2;5;6;7;5;6;2;2;5;5;7;7;4;5;4;6;4;6;7;4;5;3;5;5;5;5;3;3;6;4;3;4;5;6;3;3;4;3;7;3; GO:0099512;GO:0099513;GO:0043232;GO:0044424;GO:0044425;GO:0044422;GO:0044464;GO:0043229;GO:0015630;GO:0005622;GO:0005856;GO:0044430;GO:0030054;GO:0070160;GO:0070161;GO:0044446;GO:0016020;GO:0005874;GO:0005737;GO:0044459;GO:0016328;GO:0005912;GO:0005911;GO:0005623;GO:0043228;GO:0005923;GO:0071944;GO:0043226;GO:0005886;GO:0005575;GO:0043296; supramolecular fiber;polymeric cytoskeletal fiber;intracellular non-membrane-bounded organelle;intracellular part;membrane part;organelle part;cell part;intracellular organelle;microtubule cytoskeleton;intracellular;cytoskeleton;cytoskeletal part;cell junction;occluding junction;anchoring junction;intracellular organelle part;membrane;microtubule;cytoplasm;plasma membrane part;lateral plasma membrane;adherens junction;cell-cell junction;cell;non-membrane-bounded organelle;bicellular tight junction;cell periphery;organelle;plasma membrane;cellular_component;apical junction complex; 2;3;4;3;2;2;2;3;6;3;5;4;2;4;3;3;2;4;4;3;4;4;3;2;3;5;3;2;3;1;4; GO:0098772;GO:0005096;GO:0030695;GO:0048487;GO:0003674;GO:0005488;GO:0030234;GO:0008092;GO:0051087;GO:0060589;GO:0005515;GO:0008047;GO:0015631; molecular function regulator;GTPase activator activity;GTPase regulator activity;beta-tubulin binding;molecular_function;binding;enzyme regulator activity;cytoskeletal protein binding;chaperone binding;nucleoside-triphosphatase regulator activity;protein binding;enzyme activator activity;tubulin binding; 2;5;5;6;1;2;3;4;4;4;3;4;5; K21767 IPR033162;IPR016024;IPR011989;IPR022577; Tubulin-folding cofactor D;Armadillo-type fold;Armadillo-like helical;Tubulin-specific chaperone D, C-terminal; cytosol Hs8400736 2442.0 O [O] Posttranslational modification, protein turnover, chaperones; P14735 Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4 - [IDE_HUMAN] 1.033 1.233 0.713 0.976 1.332 1.192 0.837793998 0.048576444 0.732732733 0.043440471 0.578264396 0.012826579 0.894894895 0.310923092 GO:0080090;GO:0019222;GO:0051289;GO:0051603;GO:0044257;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0042445;GO:0051716;GO:0010259;GO:0010605;GO:0010467;GO:0048519;GO:0019725;GO:0060255;GO:0051291;GO:0030162;GO:0030163;GO:0043434;GO:0010033;GO:1901565;GO:0044700;GO:1901564;GO:0044707;GO:0019538;GO:0007154;GO:0007165;GO:0022607;GO:0009892;GO:0006807;GO:0043170;GO:0044267;GO:1901575;GO:0044265;GO:0016043;GO:0009719;GO:0065003;GO:0065007;GO:0065008;GO:0051130;GO:0050794;GO:0042447;GO:0008150;GO:0008152;GO:0043254;GO:0051604;GO:1901698;GO:1901699;GO:0006518;GO:0043171;GO:0070271;GO:0051128;GO:0044248;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0050435;GO:0044699;GO:0051248;GO:0071375;GO:0051246;GO:0006508;GO:0032502;GO:0008286;GO:0032501;GO:1901701;GO:0009987;GO:0031334;GO:0048518;GO:0032870;GO:0016485;GO:0051259;GO:0032269;GO:0032268;GO:0007568;GO:0043603;GO:0009725;GO:0045861;GO:0010992;GO:0050896;GO:0071495;GO:0043933;GO:0010815;GO:0031324;GO:0031323;GO:0042592;GO:0032869;GO:0032868;GO:0007275;GO:0071822;GO:0044087;GO:0071417;GO:0051260;GO:0051262;GO:0050789;GO:0071704;GO:0071310;GO:0044085;GO:1901142;GO:1901143;GO:0032461;GO:0006461;GO:0010817;GO:0044767;GO:0044763;GO:0010243;GO:0008340;GO:0009056;GO:0009057;GO:1901700;GO:0044238;GO:0044260;GO:0048856;GO:0044237;GO:1901652;GO:1901653;GO:0032459;GO:0044089;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;protein homotetramerization;proteolysis involved in cellular protein catabolic process;cellular protein catabolic process;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;hormone metabolic process;cellular response to stimulus;multicellular organism aging;negative regulation of macromolecule metabolic process;gene expression;negative regulation of biological process;cellular homeostasis;regulation of macromolecule metabolic process;protein heterooligomerization;regulation of proteolysis;protein catabolic process;response to peptide hormone;response to organic substance;organonitrogen compound catabolic process;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;cell communication;signal transduction;cellular component assembly;negative regulation of metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular component organization;response to endogenous stimulus;macromolecular complex assembly;biological regulation;regulation of biological quality;positive regulation of cellular component organization;regulation of cellular process;hormone catabolic process;biological_process;metabolic process;regulation of protein complex assembly;protein maturation;response to nitrogen compound;cellular response to nitrogen compound;peptide metabolic process;peptide catabolic process;protein complex biogenesis;regulation of cellular component organization;cellular catabolic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;beta-amyloid metabolic process;single-organism process;negative regulation of protein metabolic process;cellular response to peptide hormone stimulus;regulation of protein metabolic process;proteolysis;developmental process;insulin receptor signaling pathway;multicellular organismal process;cellular response to oxygen-containing compound;cellular process;positive regulation of protein complex assembly;positive regulation of biological process;cellular response to hormone stimulus;protein processing;protein oligomerization;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;aging;cellular amide metabolic process;response to hormone;negative regulation of proteolysis;ubiquitin homeostasis;response to stimulus;cellular response to endogenous stimulus;macromolecular complex subunit organization;bradykinin catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;homeostatic process;cellular response to insulin stimulus;response to insulin;multicellular organism development;protein complex subunit organization;regulation of cellular component biogenesis;cellular response to organonitrogen compound;protein homooligomerization;protein tetramerization;regulation of biological process;organic substance metabolic process;cellular response to organic substance;cellular component biogenesis;insulin metabolic process;insulin catabolic process;positive regulation of protein oligomerization;protein complex assembly;regulation of hormone levels;single-organism developmental process;single-organism cellular process;response to organonitrogen compound;determination of adult lifespan;catabolic process;macromolecule catabolic process;response to oxygen-containing compound;primary metabolic process;cellular macromolecule metabolic process;anatomical structure development;cellular metabolic process;response to peptide;cellular response to peptide;regulation of protein oligomerization;positive regulation of cellular component biogenesis;negative regulation of cellular process;positive regulation of cellular process; 4;3;8;6;6;5;6;7;2;3;3;5;4;5;2;4;4;7;6;5;5;4;5;3;4;3;4;4;4;4;3;3;4;5;4;5;3;3;5;2;3;4;3;4;1;2;4;5;4;5;5;5;4;4;4;4;2;4;3;6;2;5;6;5;5;2;8;2;5;2;4;2;5;6;6;5;5;4;5;4;6;5;2;4;4;6;4;4;4;7;6;4;5;3;5;7;7;2;3;5;3;5;6;5;5;4;3;3;4;4;3;5;4;3;4;3;3;5;6;5;3;3;3; GO:0005782;GO:0031974;GO:0031597;GO:0031981;GO:0016020;GO:0005777;GO:0031907;GO:0000502;GO:0043234;GO:0044438;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044439;GO:0044446;GO:0044444;GO:0044445;GO:0042579;GO:0005737;GO:0005634;GO:0005654;GO:0005739;GO:0009986;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005615;GO:0005886;GO:0032991;GO:0005575;GO:0070013;GO:0005576; peroxisomal matrix;membrane-enclosed lumen;cytosolic proteasome complex;nuclear lumen;membrane;peroxisome;microbody lumen;proteasome complex;protein complex;microbody part;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;peroxisomal part;intracellular organelle part;cytoplasmic part;cytosolic part;microbody;cytoplasm;nucleus;nucleoplasm;mitochondrion;cell surface;cell part;cell;intracellular;cell periphery;extracellular space;plasma membrane;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 6;2;5;5;2;6;5;4;3;4;4;3;5;4;3;2;2;3;3;2;5;3;4;5;5;4;5;5;5;3;2;2;3;3;3;3;2;1;4;2; GO:0070011;GO:0008270;GO:1901363;GO:0001948;GO:0046983;GO:0000166;GO:0046872;GO:0031626;GO:0004222;GO:0016818;GO:0001618;GO:0016817;GO:0097367;GO:0043130;GO:0032182;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0046914;GO:0008237;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0001540;GO:0005102;GO:0036094;GO:0060089;GO:0043559;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0008233;GO:0043169;GO:0042277;GO:0043167;GO:0042802;GO:0042803;GO:0033218;GO:0042165;GO:0042562;GO:0030554;GO:0005515;GO:0017046;GO:0004175;GO:0004872;GO:0001883;GO:0001882;GO:0017111;GO:0043168; peptidase activity, acting on L-amino acid peptides;zinc ion binding;heterocyclic compound binding;glycoprotein binding;protein dimerization activity;nucleotide binding;metal ion binding;beta-endorphin binding;metalloendopeptidase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;virus receptor activity;hydrolase activity, acting on acid anhydrides;carbohydrate derivative binding;ubiquitin binding;ubiquitin-like protein binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;transition metal ion binding;metallopeptidase activity;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;beta-amyloid binding;receptor binding;small molecule binding;molecular transducer activity;insulin binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;peptidase activity;cation binding;peptide binding;ion binding;identical protein binding;protein homodimerization activity;amide binding;neurotransmitter binding;hormone binding;adenyl nucleotide binding;protein binding;peptide hormone binding;endopeptidase activity;receptor activity;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;anion binding; 5;7;3;4;4;4;5;4;7;5;4;4;3;5;4;1;2;8;4;6;6;5;5;6;3;2;5;4;3;2;4;3;6;6;5;6;4;5;4;4;4;3;4;5;3;3;3;6;3;4;6;3;5;4;7;4; K01408 map05010; Alzheimer's disease; IPR007863;IPR011249;IPR011765;IPR001431;IPR032632; Peptidase M16, C-terminal;Metalloenzyme, LuxS/M16 peptidase-like;Peptidase M16, N-terminal;Peptidase M16, zinc-binding site;Peptidase M16, middle/third domain; mitochondria Hs4826770 2105.0 O [O] Posttranslational modification, protein turnover, chaperones; P12270 Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3 - [TPR_HUMAN] 1.059 0.917 1.156 1.169 0.96 0.737 1.154852781 0.046740792 1.217708333 0.068115122 1.260632497 0.248684263 0.767708333 0.001244851 GO:0033157;GO:0051169;GO:0051168;GO:0051049;GO:0034605;GO:0051985;GO:0044281;GO:0043043;GO:0051716;GO:0032434;GO:0031453;GO:0000165;GO:0016458;GO:0007088;GO:0051222;GO:0046483;GO:0019538;GO:0010638;GO:0010639;GO:0051783;GO:0051782;GO:0051784;GO:0009894;GO:0009895;GO:0009892;GO:0009890;GO:0019080;GO:0019083;GO:0090267;GO:0090266;GO:0044033;GO:0051223;GO:0050789;GO:0008645;GO:0006886;GO:0008643;GO:0071840;GO:1903308;GO:0018130;GO:0070201;GO:1903649;GO:0007051;GO:0043412;GO:0009266;GO:0007059;GO:0090169;GO:0016070;GO:0050658;GO:0071345;GO:0050657;GO:0010556;GO:0044802;GO:2001252;GO:0010558;GO:2001251;GO:0034504;GO:0071166;GO:0051493;GO:0051129;GO:0051128;GO:1903827;GO:0042176;GO:0042177;GO:1901991;GO:1901990;GO:0031497;GO:1903829;GO:0000122;GO:0000280;GO:1902850;GO:0090068;GO:0043687;GO:0044257;GO:0051983;GO:0006338;GO:0006333;GO:0090224;GO:0060341;GO:0019048;GO:0010827;GO:0022402;GO:0051306;GO:0043632;GO:0051304;GO:0051302;GO:0051301;GO:0031990;GO:0046827;GO:2000112;GO:2000113;GO:0046825;GO:0006468;GO:0000278;GO:0019219;GO:0006461;GO:0090316;GO:0006464;GO:0044765;GO:0044764;GO:0044763;GO:0031047;GO:0019941;GO:0044003;GO:0045184;GO:0051276;GO:0071426;GO:0071427;GO:0006518;GO:0006796;GO:0006793;GO:0006417;GO:0006413;GO:0006412;GO:0048523;GO:0048522;GO:0008104;GO:0007165;GO:0007166;GO:0015758;GO:0044710;GO:0045786;GO:0070849;GO:0070848;GO:1901799;GO:0033036;GO:0051051;GO:0051050;GO:2001141;GO:0051701;GO:0010033;GO:0051704;GO:0031507;GO:0018205;GO:1901673;GO:0044784;GO:0016568;GO:0045841;GO:1903533;GO:0010629;GO:0006807;GO:0034660;GO:0051028;GO:0044267;GO:0044265;GO:0044260;GO:0070271;GO:0007049;GO:0006366;GO:0009889;GO:0050794;GO:1904589;GO:0051236;GO:0051234;GO:0050896;GO:0010498;GO:0032240;GO:0046824;GO:0006511;GO:0046822;GO:0046823;GO:1903310;GO:0033044;GO:0033045;GO:0033046;GO:0033047;GO:0033043;GO:0051246;GO:0033048;GO:0070887;GO:0032886;GO:0044699;GO:0032880;GO:0051248;GO:0010564;GO:0009057;GO:0008033;GO:1902593;GO:0072594;GO:0034249;GO:0034248;GO:0000070;GO:0009408;GO:0051225;GO:1900034;GO:0033365;GO:0043933;GO:0035556;GO:0006325;GO:0006323;GO:0030071;GO:0045931;GO:0045930;GO:0045934;GO:1903362;GO:1903363;GO:0061136;GO:1902100;GO:0022411;GO:0042221;GO:0006996;GO:0009628;GO:0005975;GO:0044237;GO:0006399;GO:0044403;GO:0006396;GO:0006997;GO:0032388;GO:0019221;GO:0019222;GO:0032435;GO:0032386;GO:0032387;GO:0048583;GO:0010965;GO:1901362;GO:1901360;GO:0032446;GO:0019058;GO:0051817;GO:0048518;GO:0048519;GO:0019054;GO:0034470;GO:0006606;GO:0030397;GO:0006605;GO:0007077;GO:1902099;GO:0044700;GO:1901564;GO:1901566;GO:0045799;GO:0033554;GO:0070507;GO:0071103;GO:0022607;GO:2000816;GO:0043170;GO:0097659;GO:0031577;GO:0034097;GO:0006810;GO:0006950;GO:0034654;GO:0042306;GO:0001672;GO:0045787;GO:0051603;GO:1900182;GO:0044271;GO:0046907;GO:0080134;GO:0080135;GO:0007052;GO:0006355;GO:0006357;GO:0006351;GO:0010608;GO:1903051;GO:0032774;GO:0010256;GO:0042307;GO:0010847;GO:1904951;GO:0009719;GO:0006139;GO:0043161;GO:0051081;GO:0046831;GO:0046832;GO:0006508;GO:1900180;GO:0031330;GO:1903050;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0000189;GO:0044744;GO:0032879;GO:0016482;GO:0044770;GO:0000819;GO:0051253;GO:0051252;GO:0044068;GO:0044772;GO:1902275;GO:0070828;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0034613;GO:0006913;GO:1902679;GO:0009058;GO:0009059;GO:0051170;GO:0051171;GO:0051172;GO:0051649;GO:0070925;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0031445;GO:0000075;GO:0051726;GO:1902589;GO:0007094;GO:1902582;GO:1902580;GO:0007091;GO:0007093;GO:0080090;GO:0061024;GO:0023014;GO:0010605;GO:0070727;GO:0032239;GO:0070647;GO:0018193;GO:0044419;GO:1904591;GO:0045839;GO:0098813;GO:0060255;GO:0006446;GO:0030162;GO:0030163;GO:0006405;GO:0019438;GO:1903650;GO:1903651;GO:0000226;GO:0007067;GO:1901576;GO:0007346;GO:0016043;GO:0065003;GO:0045947;GO:0065007;GO:0065008;GO:0051130;GO:0071174;GO:0071173;GO:1901987;GO:0036211;GO:0008150;GO:0008152;GO:0043254;GO:1901988;GO:1901978;GO:1901976;GO:0015931;GO:0016310;GO:0044248;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0006611;GO:0090231;GO:0090232;GO:0044238;GO:0017038;GO:0045892;GO:0007010;GO:0016925;GO:0055085;GO:0043604;GO:0032269;GO:0032268;GO:0043603;GO:0017148;GO:0045861;GO:0031329;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:1903047;GO:0090304;GO:0010948;GO:0090307;GO:0006998;GO:0006999;GO:0035455;GO:0035457;GO:0071822;GO:0010467;GO:1902115;GO:0006403;GO:0006404;GO:0010468;GO:0006406;GO:0016032;GO:1903504;GO:1901575;GO:0007154;GO:0060236;GO:0007017;GO:0044087;GO:0044085;GO:0048285;GO:0015749;GO:0015031;GO:0035821;GO:0044089; regulation of intracellular protein transport;nuclear transport;nuclear export;regulation of transport;cellular response to heat;negative regulation of chromosome segregation;small molecule metabolic process;peptide biosynthetic process;cellular response to stimulus;regulation of proteasomal ubiquitin-dependent protein catabolic process;positive regulation of heterochromatin assembly;MAPK cascade;gene silencing;regulation of mitotic nuclear division;positive regulation of protein transport;heterocycle metabolic process;protein metabolic process;positive regulation of organelle organization;negative regulation of organelle organization;regulation of nuclear division;negative regulation of cell division;negative regulation of nuclear division;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;negative regulation of biosynthetic process;viral gene expression;viral transcription;positive regulation of mitotic cell cycle spindle assembly checkpoint;regulation of mitotic cell cycle spindle assembly checkpoint;multi-organism metabolic process;regulation of protein transport;regulation of biological process;hexose transport;intracellular protein transport;carbohydrate transport;cellular component organization or biogenesis;regulation of chromatin modification;heterocycle biosynthetic process;regulation of establishment of protein localization;regulation of cytoplasmic transport;spindle organization;macromolecule modification;response to temperature stimulus;chromosome segregation;regulation of spindle assembly;RNA metabolic process;RNA transport;cellular response to cytokine stimulus;nucleic acid transport;regulation of macromolecule biosynthetic process;single-organism membrane organization;positive regulation of chromosome organization;negative regulation of macromolecule biosynthetic process;negative regulation of chromosome organization;protein localization to nucleus;ribonucleoprotein complex localization;regulation of cytoskeleton organization;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;regulation of protein catabolic process;negative regulation of protein catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;chromatin assembly;positive regulation of cellular protein localization;negative regulation of transcription from RNA polymerase II promoter;nuclear division;microtubule cytoskeleton organization involved in mitosis;positive regulation of cell cycle process;post-translational protein modification;cellular protein catabolic process;regulation of chromosome segregation;chromatin remodeling;chromatin assembly or disassembly;regulation of spindle organization;regulation of cellular localization;modulation by virus of host morphology or physiology;regulation of glucose transport;cell cycle process;mitotic sister chromatid separation;modification-dependent macromolecule catabolic process;chromosome separation;regulation of cell division;cell division;mRNA export from nucleus in response to heat stress;positive regulation of protein export from nucleus;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of protein export from nucleus;protein phosphorylation;mitotic cell cycle;regulation of nucleobase-containing compound metabolic process;protein complex assembly;positive regulation of intracellular protein transport;cellular protein modification process;single-organism transport;multi-organism cellular process;single-organism cellular process;gene silencing by RNA;modification-dependent protein catabolic process;modification by symbiont of host morphology or physiology;establishment of protein localization;chromosome organization;ribonucleoprotein complex export from nucleus;mRNA-containing ribonucleoprotein complex export from nucleus;peptide metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of translation;translational initiation;translation;negative regulation of cellular process;positive regulation of cellular process;protein localization;signal transduction;cell surface receptor signaling pathway;glucose transport;single-organism metabolic process;negative regulation of cell cycle;response to epidermal growth factor;response to growth factor;negative regulation of proteasomal protein catabolic process;macromolecule localization;negative regulation of transport;positive regulation of transport;regulation of RNA biosynthetic process;interaction with host;response to organic substance;multi-organism process;heterochromatin assembly;peptidyl-lysine modification;regulation of mitotic spindle assembly;metaphase/anaphase transition of cell cycle;chromatin modification;negative regulation of mitotic metaphase/anaphase transition;regulation of protein targeting;negative regulation of gene expression;nitrogen compound metabolic process;ncRNA metabolic process;mRNA transport;cellular protein metabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;protein complex biogenesis;cell cycle;transcription from RNA polymerase II promoter;regulation of biosynthetic process;regulation of cellular process;regulation of protein import;establishment of RNA localization;establishment of localization;response to stimulus;proteasomal protein catabolic process;negative regulation of nucleobase-containing compound transport;positive regulation of nucleocytoplasmic transport;ubiquitin-dependent protein catabolic process;regulation of nucleocytoplasmic transport;negative regulation of nucleocytoplasmic transport;positive regulation of chromatin modification;regulation of chromosome organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;regulation of organelle organization;regulation of protein metabolic process;negative regulation of mitotic sister chromatid segregation;cellular response to chemical stimulus;regulation of microtubule-based process;single-organism process;regulation of protein localization;negative regulation of protein metabolic process;regulation of cell cycle process;macromolecule catabolic process;tRNA processing;single-organism nuclear import;establishment of protein localization to organelle;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;mitotic sister chromatid segregation;response to heat;spindle assembly;regulation of cellular response to heat;protein localization to organelle;macromolecular complex subunit organization;intracellular signal transduction;chromatin organization;DNA packaging;regulation of mitotic metaphase/anaphase transition;positive regulation of mitotic cell cycle;negative regulation of mitotic cell cycle;negative regulation of nucleobase-containing compound metabolic process;regulation of cellular protein catabolic process;negative regulation of cellular protein catabolic process;regulation of proteasomal protein catabolic process;negative regulation of metaphase/anaphase transition of cell cycle;cellular component disassembly;response to chemical;organelle organization;response to abiotic stimulus;carbohydrate metabolic process;cellular metabolic process;tRNA metabolic process;symbiosis, encompassing mutualism through parasitism;RNA processing;nucleus organization;positive regulation of intracellular transport;cytokine-mediated signaling pathway;regulation of metabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of intracellular transport;negative regulation of intracellular transport;regulation of response to stimulus;regulation of mitotic sister chromatid separation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;protein modification by small protein conjugation;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;positive regulation of biological process;negative regulation of biological process;modulation by virus of host process;ncRNA processing;protein import into nucleus;membrane disassembly;protein targeting;mitotic nuclear envelope disassembly;regulation of metaphase/anaphase transition of cell cycle;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;positive regulation of chromatin assembly or disassembly;cellular response to stress;regulation of microtubule cytoskeleton organization;DNA conformation change;cellular component assembly;negative regulation of mitotic sister chromatid separation;macromolecule metabolic process;nucleic acid-templated transcription;spindle checkpoint;response to cytokine;transport;response to stress;nucleobase-containing compound biosynthetic process;regulation of protein import into nucleus;regulation of chromatin assembly or disassembly;positive regulation of cell cycle;proteolysis involved in cellular protein catabolic process;positive regulation of protein localization to nucleus;cellular nitrogen compound biosynthetic process;intracellular transport;regulation of response to stress;regulation of cellular response to stress;mitotic spindle organization;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;posttranscriptional regulation of gene expression;negative regulation of proteolysis involved in cellular protein catabolic process;RNA biosynthetic process;endomembrane system organization;positive regulation of protein import into nucleus;regulation of chromatin assembly;positive regulation of establishment of protein localization;response to endogenous stimulus;nucleobase-containing compound metabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;nuclear envelope disassembly;regulation of RNA export from nucleus;negative regulation of RNA export from nucleus;proteolysis;regulation of protein localization to nucleus;negative regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;MAPK import into nucleus;protein targeting to nucleus;regulation of localization;cytosolic transport;cell cycle phase transition;sister chromatid segregation;negative regulation of RNA metabolic process;regulation of RNA metabolic process;modulation by symbiont of host cellular process;mitotic cell cycle phase transition;regulation of chromatin organization;heterochromatin organization;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;cellular protein localization;nucleocytoplasmic transport;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;nuclear import;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;organelle assembly;catabolic process;localization;single-organism localization;cellular localization;regulation of heterochromatin assembly;cell cycle checkpoint;regulation of cell cycle;single-organism organelle organization;mitotic spindle assembly checkpoint;single-organism intracellular transport;single-organism cellular localization;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle checkpoint;regulation of primary metabolic process;membrane organization;signal transduction by protein phosphorylation;negative regulation of macromolecule metabolic process;cellular macromolecule localization;regulation of nucleobase-containing compound transport;protein modification by small protein conjugation or removal;peptidyl-amino acid modification;interspecies interaction between organisms;positive regulation of protein import;negative regulation of mitotic nuclear division;nuclear chromosome segregation;regulation of macromolecule metabolic process;regulation of translational initiation;regulation of proteolysis;protein catabolic process;RNA export from nucleus;aromatic compound biosynthetic process;negative regulation of cytoplasmic transport;positive regulation of cytoplasmic transport;microtubule cytoskeleton organization;mitotic nuclear division;organic substance biosynthetic process;regulation of mitotic cell cycle;cellular component organization;macromolecular complex assembly;negative regulation of translational initiation;biological regulation;regulation of biological quality;positive regulation of cellular component organization;mitotic spindle checkpoint;spindle assembly checkpoint;regulation of cell cycle phase transition;protein modification process;biological_process;metabolic process;regulation of protein complex assembly;negative regulation of cell cycle phase transition;positive regulation of cell cycle checkpoint;regulation of cell cycle checkpoint;nucleobase-containing compound transport;phosphorylation;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;protein export from nucleus;regulation of spindle checkpoint;positive regulation of spindle checkpoint;primary metabolic process;protein import;negative regulation of transcription, DNA-templated;cytoskeleton organization;protein sumoylation;transmembrane transport;amide biosynthetic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;negative regulation of translation;negative regulation of proteolysis;regulation of cellular catabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;negative regulation of cell cycle process;mitotic spindle assembly;nuclear envelope organization;nuclear pore organization;response to interferon-alpha;cellular response to interferon-alpha;protein complex subunit organization;gene expression;regulation of organelle assembly;RNA localization;RNA import into nucleus;regulation of gene expression;mRNA export from nucleus;viral process;regulation of mitotic spindle checkpoint;organic substance catabolic process;cell communication;regulation of mitotic spindle organization;microtubule-based process;regulation of cellular component biogenesis;cellular component biogenesis;organelle fission;monosaccharide transport;protein transport;modification of morphology or physiology of other organism;positive regulation of cellular component biogenesis; 6;6;8;4;5;4;4;6;3;8;4;5;4;6;4;4;4;5;5;5;4;5;4;4;3;4;4;5;6;7;3;5;2;7;6;5;2;7;5;5;6;5;5;4;4;5;5;5;6;7;5;4;6;5;6;7;4;6;4;4;5;5;5;6;6;6;3;7;6;6;5;7;6;4;7;6;6;4;5;5;4;6;6;5;4;4;4;5;6;6;7;7;5;5;5;4;6;4;3;3;5;7;5;4;5;5;6;5;5;4;6;4;6;3;3;4;4;5;8;3;4;4;5;7;3;3;3;6;4;4;2;7;8;6;6;6;7;7;5;3;6;6;5;5;4;4;4;7;4;3;6;4;3;2;6;4;6;8;7;6;7;6;5;5;6;5;5;6;4;4;2;4;5;5;5;8;6;5;5;5;6;4;6;5;6;4;5;5;7;7;5;5;5;6;6;7;7;4;3;4;3;4;3;7;4;6;5;4;6;3;8;5;4;3;7;5;4;8;5;4;2;2;5;7;5;5;6;6;6;3;4;5;7;4;5;6;4;7;4;7;6;5;4;3;5;6;7;4;6;4;5;5;4;4;6;6;7;6;6;7;6;4;5;4;3;3;4;7;6;6;5;5;6;5;7;2;4;7;7;6;5;3;6;5;5;5;5;4;6;6;6;5;3;5;5;5;7;6;3;5;8;4;4;4;5;3;2;3;3;5;5;4;4;6;5;4;6;6;4;4;4;4;4;5;7;7;3;5;6;5;4;5;6;5;6;5;5;5;5;5;4;5;3;5;5;2;3;4;6;7;6;5;1;2;4;6;6;6;6;6;4;4;4;2;5;6;7;7;3;5;6;5;9;4;6;5;5;5;6;6;5;5;5;4;4;5;5;5;6;5;6;6;7;5;5;4;4;6;5;6;4;7;4;4;6;4;3;3;5;6;5;3;3; GO:0044428;GO:0044424;GO:0044425;GO:0044427;GO:0044422;GO:0005654;GO:0005875;GO:0044615;GO:0098687;GO:0044464;GO:0070013;GO:0016020;GO:1902494;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044430;GO:0005643;GO:0019898;GO:0042405;GO:0031090;GO:0000776;GO:0005868;GO:0016234;GO:0005819;GO:0034399;GO:0031974;GO:0031975;GO:0000775;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0012505;GO:0044446;GO:0005634;GO:0005635;GO:0072686;GO:0031981;GO:0031965;GO:0031967;GO:0005694;GO:0005737;GO:0005623;GO:0005622;GO:0030286;GO:0015630;GO:0032991;GO:0005575; nuclear part;intracellular part;membrane part;chromosomal part;organelle part;nucleoplasm;microtubule associated complex;nuclear pore nuclear basket;chromosomal region;cell part;intracellular organelle lumen;membrane;catalytic complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytoskeletal part;nuclear pore;extrinsic component of membrane;nuclear inclusion body;organelle membrane;kinetochore;cytoplasmic dynein complex;inclusion body;spindle;nuclear periphery;membrane-enclosed lumen;envelope;chromosome, centromeric region;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;endomembrane system;intracellular organelle part;nucleus;nuclear envelope;mitotic spindle;nuclear lumen;nuclear membrane;organelle envelope;chromosome;cytoplasm;cell;intracellular;dynein complex;microtubule cytoskeleton;macromolecular complex;cellular_component; 4;3;2;4;2;5;4;4;5;2;4;2;4;3;4;4;3;4;5;3;5;3;4;6;4;5;5;2;3;6;3;3;3;2;5;3;3;5;4;6;5;4;4;5;4;2;3;5;6;2;1; GO:0031072;GO:0005488;GO:0005487;GO:0051019;GO:0070840;GO:0046983;GO:0019899;GO:0032403;GO:0044822;GO:0005515;GO:0003674;GO:0005215;GO:1901363;GO:0019901;GO:0019900;GO:0044877;GO:0003676;GO:0008092;GO:0097159;GO:0042802;GO:0042803;GO:0003723;GO:0003682;GO:0003729;GO:0015631; heat shock protein binding;binding;nucleocytoplasmic transporter activity;mitogen-activated protein kinase binding;dynein complex binding;protein dimerization activity;enzyme binding;protein complex binding;poly(A) RNA binding;protein binding;molecular_function;transporter activity;heterocyclic compound binding;protein kinase binding;kinase binding;macromolecular complex binding;nucleic acid binding;cytoskeletal protein binding;organic cyclic compound binding;identical protein binding;protein homodimerization activity;RNA binding;chromatin binding;mRNA binding;tubulin binding; 4;2;3;7;5;4;4;4;6;3;1;2;3;6;5;3;4;4;3;4;5;5;4;7;5; K09291 map03013;map05200;map05216; RNA transport;Pathways in cancer;Thyroid cancer; IPR012929; Nucleoprotein TPR/MLP1; nucleus Hs4507659 4722.0 S [S] Function unknown; Q6P2M8 Calcium/calmodulin-dependent protein kinase type 1B OS=Homo sapiens OX=9606 GN=PNCK PE=2 SV=2 - [KCC1B_HUMAN] 0.886 0.734 1.739 0.811 0.884 0.907 1.207084469 0.284090769 0.917420814 0.703706342 2.369209809 7.02E-05 1.0260181 0.566795007 GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;4;5;4;2;2;3;1;3; GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0000166;GO:1901265;GO:0001882;GO:0043167;GO:0004674;GO:0016740;GO:0001883;GO:0032549;GO:0017076;GO:0004672;GO:0005524;GO:0043168;GO:0016301;GO:0036094;GO:0032555;GO:0030554;GO:0097367;GO:0097159;GO:0003824;GO:0004683;GO:0016773;GO:0032559;GO:0016772;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;nucleotide binding;nucleoside phosphate binding;nucleoside binding;ion binding;protein serine/threonine kinase activity;transferase activity;purine nucleoside binding;ribonucleoside binding;purine nucleotide binding;protein kinase activity;ATP binding;anion binding;kinase activity;small molecule binding;purine ribonucleotide binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;catalytic activity;calmodulin-dependent protein kinase activity;phosphotransferase activity, alcohol group as acceptor;adenyl ribonucleotide binding;transferase activity, transferring phosphorus-containing groups;purine ribonucleoside binding;ribonucleotide binding; 5;3;1;2;4;4;4;3;7;3;5;5;5;6;6;4;5;3;5;6;3;3;2;8;5;6;4;6;4; K08795 IPR017441;IPR008271;IPR020636;IPR011009;IPR000719; Protein kinase, ATP binding site;Serine/threonine-protein kinase, active site;Calcium/calmodulin-dependent/calcium-dependent protein kinase;Protein kinase-like domain;Protein kinase domain; cytosol Hs9966875 476.0 T [T] Signal transduction mechanisms; P02746 Complement C1q subcomponent subunit B OS=Homo sapiens OX=9606 GN=C1QB PE=1 SV=3 - [C1QB_HUMAN] 1.044 1.037 0.89 0.958 1.033 1.112 1.006750241 0.841696548 0.927395934 0.978407493 0.858244937 0.296738591 1.076476283 0.08065574 GO:0048584;GO:0048583;GO:0050789;GO:0002455;GO:0044699;GO:0002376;GO:0044710;GO:0006959;GO:0072376;GO:0007275;GO:0071704;GO:0002684;GO:0048513;GO:0002682;GO:0043583;GO:0048518;GO:0065007;GO:0032502;GO:0019724;GO:0032501;GO:0006956;GO:0044238;GO:0045087;GO:0044767;GO:0002449;GO:0006950;GO:0016064;GO:0008150;GO:0002460;GO:0008152;GO:0006955;GO:0006958;GO:0006952;GO:0048839;GO:0050776;GO:0044707;GO:0007423;GO:0019538;GO:0050896;GO:0048856;GO:0050778;GO:0002443;GO:0043170;GO:0002250;GO:0002253;GO:0002252;GO:0048731; positive regulation of response to stimulus;regulation of response to stimulus;regulation of biological process;humoral immune response mediated by circulating immunoglobulin;single-organism process;immune system process;single-organism metabolic process;humoral immune response;protein activation cascade;multicellular organism development;organic substance metabolic process;positive regulation of immune system process;animal organ development;regulation of immune system process;ear development;positive regulation of biological process;biological regulation;developmental process;B cell mediated immunity;multicellular organismal process;complement activation;primary metabolic process;innate immune response;single-organism developmental process;lymphocyte mediated immunity;response to stress;immunoglobulin mediated immune response;biological_process;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;metabolic process;immune response;complement activation, classical pathway;defense response;inner ear development;regulation of immune response;single-multicellular organism process;sensory organ development;protein metabolic process;response to stimulus;anatomical structure development;positive regulation of immune response;leukocyte mediated immunity;macromolecule metabolic process;adaptive immune response;activation of immune response;immune effector process;system development; 3;3;2;5;2;2;3;4;3;4;3;3;4;3;5;2;2;2;6;2;4;3;4;3;5;3;7;1;5;2;3;5;4;4;4;3;4;4;2;3;4;4;4;4;3;3;4; GO:0043227;GO:0043226;GO:0031982;GO:0005615;GO:0072562;GO:0005602;GO:0032991;GO:1903561;GO:0070062;GO:0043234;GO:0043230;GO:0005581;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;vesicle;extracellular space;blood microparticle;complement component C1 complex;macromolecular complex;extracellular vesicle;extracellular exosome;protein complex;extracellular organelle;collagen trimer;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;3;2;3;4;3;3;4;1;2;2; K03987 map04610;map05020;map05133;map05142;map05150;map05322; Complement and coagulation cascades;Prion diseases;Pertussis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Systemic lupus erythematosus; IPR008983;IPR008160;IPR001073; Tumour necrosis factor-like domain;Collagen triple helix repeat;C1q domain; extracellular 284047272 67.8 G [G] Carbohydrate transport and metabolism; COG4632 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acety... Q11206 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 OS=Homo sapiens OX=9606 GN=ST3GAL4 PE=2 SV=1 - [SIA4C_HUMAN] 1.101 0.749 1.205 0.968 0.969 1.467 1.469959947 nan 0.998968008 nan 1.608811749 nan 1.513931889 nan GO:0044281;GO:0044710;GO:0044711;GO:0018193;GO:0042339;GO:0006664;GO:0006665;GO:0006687;GO:0043436;GO:0003008;GO:1901564;GO:1901566;GO:0019538;GO:0034641;GO:0030203;GO:0018146;GO:0006807;GO:0043170;GO:0044267;GO:0044260;GO:0006688;GO:0030148;GO:0016266;GO:0006629;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0001573;GO:0044271;GO:0001574;GO:0044272;GO:0050890;GO:0043413;GO:0043603;GO:0006022;GO:0006023;GO:0006024;GO:0018196;GO:0009311;GO:0006672;GO:0044249;GO:0034645;GO:0044699;GO:0046467;GO:1903509;GO:0032501;GO:0006643;GO:0050877;GO:0043687;GO:0009987;GO:0009247;GO:0006493;GO:0044255;GO:0043604;GO:0006082;GO:1901137;GO:1901135;GO:1903510;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0006488;GO:0071704;GO:0018279;GO:1901576;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0008610;GO:0044238;GO:0005975;GO:0006490;GO:0044237;GO:0006790;GO:0046513; small molecule metabolic process;single-organism metabolic process;single-organism biosynthetic process;peptidyl-amino acid modification;keratan sulfate metabolic process;glycolipid metabolic process;sphingolipid metabolic process;glycosphingolipid metabolic process;oxoacid metabolic process;system process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular nitrogen compound metabolic process;glycosaminoglycan metabolic process;keratan sulfate biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;glycosphingolipid biosynthetic process;sphingolipid biosynthetic process;O-glycan processing;lipid metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;ganglioside metabolic process;cellular nitrogen compound biosynthetic process;ganglioside biosynthetic process;sulfur compound biosynthetic process;cognition;macromolecule glycosylation;cellular amide metabolic process;aminoglycan metabolic process;aminoglycan biosynthetic process;glycosaminoglycan biosynthetic process;peptidyl-asparagine modification;oligosaccharide metabolic process;ceramide metabolic process;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;membrane lipid biosynthetic process;liposaccharide metabolic process;multicellular organismal process;membrane lipid metabolic process;neurological system process;post-translational protein modification;cellular process;glycolipid biosynthetic process;protein O-linked glycosylation;cellular lipid metabolic process;amide biosynthetic process;organic acid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;mucopolysaccharide metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;dolichol-linked oligosaccharide biosynthetic process;organic substance metabolic process;protein N-linked glycosylation via asparagine;organic substance biosynthetic process;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;lipid biosynthetic process;primary metabolic process;carbohydrate metabolic process;oligosaccharide-lipid intermediate biosynthetic process;cellular metabolic process;sulfur compound metabolic process;ceramide biosynthetic process; 4;3;4;7;5;6;5;6;5;3;4;5;4;4;6;6;3;4;5;4;7;6;6;4;5;5;1;2;4;7;5;8;5;5;6;5;5;5;6;8;5;6;4;5;2;5;5;2;5;4;7;2;6;5;4;6;4;5;4;7;5;6;4;5;6;3;6;4;5;6;3;5;3;5;3;4;5;3;4;7; GO:0032580;GO:0031982;GO:0016021;GO:0016020;GO:0005795;GO:0005794;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0030173;GO:0043227;GO:0043226;GO:0044431;GO:0031224;GO:0031985;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0031228;GO:0031301;GO:0031300;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0031984;GO:0070062;GO:1903561;GO:0005575;GO:0005576;GO:0098791; Golgi cisterna membrane;vesicle;integral component of membrane;membrane;Golgi stack;Golgi apparatus;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;integral component of Golgi membrane;membrane-bounded organelle;organelle;Golgi apparatus part;intrinsic component of membrane;Golgi cisterna;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intrinsic component of Golgi membrane;integral component of organelle membrane;intrinsic component of organelle membrane;cytoplasm;organelle membrane;cell part;cell;intracellular;organelle subcompartment;extracellular exosome;extracellular vesicle;cellular_component;extracellular region;Golgi subcompartment; 6;4;4;2;5;4;4;3;4;3;2;2;2;3;5;3;2;4;3;6;3;5;3;4;4;4;3;4;3;2;2;3;4;4;3;1;2;5; GO:0008373;GO:0016740;GO:0016757;GO:0003836;GO:0003674;GO:0047288;GO:0003824; sialyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;molecular_function;monosialoganglioside sialyltransferase activity;catalytic activity; 5;3;4;6;1;6;2; K03494 map00601;map01100; Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways; IPR012163;IPR001675; Sialyltransferase;Glycosyl transferase family 29; plasma membrane Hs5454058 676.0 G [G] Carbohydrate transport and metabolism; P18084 Integrin beta-5 OS=Homo sapiens OX=9606 GN=ITGB5 PE=1 SV=1 - [ITB5_HUMAN] 0.583 0.513 2.354 0.649 0.803 0.82 1.136452242 0.301940085 0.808219178 0.083783056 4.588693957 0.003323442 1.02117061 0.736499267 GO:0007492;GO:0002478;GO:0007160;GO:0003012;GO:0007165;GO:0007166;GO:0090136;GO:0071840;GO:0051716;GO:0048869;GO:0070848;GO:0007178;GO:0031589;GO:0006936;GO:0044700;GO:0010033;GO:0007179;GO:0003008;GO:0044707;GO:0002376;GO:0022607;GO:0007167;GO:0048002;GO:0016043;GO:0030198;GO:0065007;GO:0048646;GO:0043149;GO:0009719;GO:0019882;GO:0098602;GO:0019884;GO:0098609;GO:0009888;GO:0050794;GO:0008150;GO:0035987;GO:0050896;GO:0007369;GO:0061572;GO:0030154;GO:0009790;GO:0023052;GO:0070887;GO:0042221;GO:0009653;GO:0044699;GO:0001706;GO:0001704;GO:0022610;GO:0032502;GO:0032501;GO:0009987;GO:0051017;GO:0071363;GO:0071560;GO:0007229;GO:0030038;GO:0071495;GO:0016337;GO:0031032;GO:0043933;GO:0030036;GO:0042590;GO:0007275;GO:0002474;GO:0071822;GO:0002479;GO:0050789;GO:0071310;GO:0043062;GO:0071559;GO:0048598;GO:0030029;GO:0044767;GO:0044763;GO:0007155;GO:0007154;GO:0006996;GO:0007015;GO:0007010;GO:0048856;GO:1902589;GO:0044085; endoderm development;antigen processing and presentation of exogenous peptide antigen;cell-matrix adhesion;muscle system process;signal transduction;cell surface receptor signaling pathway;epithelial cell-cell adhesion;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;response to growth factor;transmembrane receptor protein serine/threonine kinase signaling pathway;cell-substrate adhesion;muscle contraction;single organism signaling;response to organic substance;transforming growth factor beta receptor signaling pathway;system process;single-multicellular organism process;immune system process;cellular component assembly;enzyme linked receptor protein signaling pathway;antigen processing and presentation of peptide antigen;cellular component organization;extracellular matrix organization;biological regulation;anatomical structure formation involved in morphogenesis;stress fiber assembly;response to endogenous stimulus;antigen processing and presentation;single organism cell adhesion;antigen processing and presentation of exogenous antigen;cell-cell adhesion;tissue development;regulation of cellular process;biological_process;endodermal cell differentiation;response to stimulus;gastrulation;actin filament bundle organization;cell differentiation;embryo development;signaling;cellular response to chemical stimulus;response to chemical;anatomical structure morphogenesis;single-organism process;endoderm formation;formation of primary germ layer;biological adhesion;developmental process;multicellular organismal process;cellular process;actin filament bundle assembly;cellular response to growth factor stimulus;cellular response to transforming growth factor beta stimulus;integrin-mediated signaling pathway;contractile actin filament bundle assembly;cellular response to endogenous stimulus;single organismal cell-cell adhesion;actomyosin structure organization;macromolecular complex subunit organization;actin cytoskeleton organization;antigen processing and presentation of exogenous peptide antigen via MHC class I;multicellular organism development;antigen processing and presentation of peptide antigen via MHC class I;protein complex subunit organization;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;regulation of biological process;cellular response to organic substance;extracellular structure organization;response to transforming growth factor beta;embryonic morphogenesis;actin filament-based process;single-organism developmental process;single-organism cellular process;cell adhesion;cell communication;organelle organization;actin filament organization;cytoskeleton organization;anatomical structure development;single-organism organelle organization;cellular component biogenesis; 5;5;5;4;4;5;5;2;3;4;5;7;4;5;3;4;6;3;3;2;4;6;4;3;5;2;3;7;3;3;3;4;4;4;3;1;6;2;5;7;5;5;2;4;3;3;2;5;4;2;2;2;2;5;6;5;6;6;4;4;6;4;5;6;4;5;5;7;2;5;4;4;4;4;3;3;3;4;4;6;5;3;4;3; GO:0030055;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0043234;GO:0043235;GO:0043230;GO:0043231;GO:0030054;GO:0034684;GO:0044424;GO:0044425;GO:0044421;GO:0043229;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0031224;GO:0070161;GO:0008305;GO:0045335;GO:0097708;GO:0044444;GO:0098636;GO:0031226;GO:0005737;GO:0031410;GO:0044459;GO:0009986;GO:0005912;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0030139;GO:0071944;GO:0070062;GO:0098802;GO:0005576;GO:0005887;GO:0005886;GO:1903561;GO:0005575;GO:0098797;GO:0098796; cell-substrate junction;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;protein complex;receptor complex;extracellular organelle;intracellular membrane-bounded organelle;cell junction;integrin alphav-beta5 complex;intracellular part;membrane part;extracellular region part;intracellular organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;intrinsic component of membrane;anchoring junction;integrin complex;phagocytic vesicle;intracellular vesicle;cytoplasmic part;protein complex involved in cell adhesion;intrinsic component of plasma membrane;cytoplasm;cytoplasmic vesicle;plasma membrane part;cell surface;adherens junction;macromolecular complex;cell part;cell;intracellular;endocytic vesicle;cell periphery;extracellular exosome;plasma membrane receptor complex;extracellular region;integral component of plasma membrane;plasma membrane;extracellular vesicle;cellular_component;plasma membrane protein complex;membrane protein complex; 3;4;5;4;2;5;3;4;3;4;2;6;3;2;2;3;4;5;3;2;3;3;5;7;4;4;4;4;4;5;3;3;4;2;2;2;3;6;3;4;4;2;4;3;3;1;4;3; GO:0060089;GO:0001618;GO:0003674;GO:0004872; molecular transducer activity;virus receptor activity;molecular_function;receptor activity; 2;4;1;3; K06588 map04145;map04151;map04510;map04512;map04810;map05205;map05410;map05412;map05414; Phagosome;PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;Proteoglycans in cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy; IPR027067;IPR002035;IPR033760;IPR002369;IPR016201;IPR015812;IPR012896;IPR014836;IPR032695; Integrin beta-5 subunit;von Willebrand factor, type A;Integrin beta N-terminal;Integrin beta subunit, VWA domain;PSI domain;Integrin beta subunit;Integrin beta subunit, tail;Integrin beta subunit, cytoplasmic domain;Integrin domain; extracellular Hs20127446 1650.0 TW [T] Signal transduction mechanisms;[W] Extracellular structures; Q8IXF0 Neuronal PAS domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NPAS3 PE=2 SV=1 - [NPAS3_HUMAN] 1.047 1.102 0.721 1.309 1.127 1.015 0.950090744 nan 1.161490683 nan 0.654264973 nan 0.900621118 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010604;GO:0048518;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0032502;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;developmental process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;2;4;6;4;5;3;4;3;7;4;4;2;7;5;4;3;1;2;5;5;5;6;5;7;6;6;4;4;5;4;7;2;4;7;6;5;5;4;6;5;2;5;5;4;4;5;6;2;3;5;5;5;5;5;3;5;4;4;3;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;3;2;5;3;4;5;2;2;1;4; GO:0001071;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000981;GO:0097159;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;transcription factor activity, sequence-specific DNA binding; 2;3;1;2;4;5;4;3;3; K09098 IPR011598;IPR013767;IPR000014;IPR013655; Myc-type, basic helix-loop-helix (bHLH) domain;PAS fold;PAS domain;PAS fold-3; nucleus Hs11545847 1835.0 TK [T] Signal transduction mechanisms;[K] Transcription; P29122 Proprotein convertase subtilisin/kexin type 6 OS=Homo sapiens OX=9606 GN=PCSK6 PE=1 SV=1 - [PCSK6_HUMAN] 0.991 1.018 1.025 1.005 1.007 1.485 0.973477407 0.69343033 0.998013903 0.968849552 1.006876228 0.859302256 1.474677259 0.073704144 GO:0080090;GO:0019222;GO:0048583;GO:0030509;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0030510;GO:1901362;GO:1901360;GO:0042445;GO:0051716;GO:0009966;GO:0007368;GO:0070848;GO:0007178;GO:0038179;GO:0060255;GO:0003002;GO:2001141;GO:0010033;GO:0050794;GO:0046483;GO:0044700;GO:1901564;GO:0044707;GO:0019538;GO:0019438;GO:0034645;GO:0023051;GO:0006807;GO:0000578;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0009948;GO:0009719;GO:0065007;GO:0006366;GO:0065008;GO:0018130;GO:0009880;GO:0006810;GO:0009889;GO:0071310;GO:0032898;GO:0008150;GO:0008152;GO:0048011;GO:0007351;GO:0007350;GO:0007354;GO:0016070;GO:0046903;GO:0044271;GO:0009952;GO:0051604;GO:0050896;GO:0009058;GO:0006355;GO:0006357;GO:0006351;GO:0006518;GO:0071772;GO:0071773;GO:0032774;GO:0009790;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0009799;GO:0009798;GO:0010646;GO:0044699;GO:0006139;GO:0090287;GO:0051234;GO:0006508;GO:0032502;GO:0032501;GO:0010556;GO:0031323;GO:0009987;GO:0006725;GO:1903506;GO:0016485;GO:0016486;GO:0071363;GO:0043603;GO:1901135;GO:0051252;GO:0032940;GO:0034654;GO:0071495;GO:0031326;GO:0032902;GO:0090304;GO:0035282;GO:0009100;GO:0007275;GO:0007389;GO:2000112;GO:0071704;GO:0010467;GO:0010468;GO:0090092;GO:0019219;GO:0010817;GO:0044767;GO:0008595;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0048856;GO:0044237;GO:0032455;GO:0009855;GO:0044249; regulation of primary metabolic process;regulation of metabolic process;regulation of response to stimulus;BMP signaling pathway;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of BMP signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;hormone metabolic process;cellular response to stimulus;regulation of signal transduction;determination of left/right symmetry;response to growth factor;transmembrane receptor protein serine/threonine kinase signaling pathway;neurotrophin signaling pathway;regulation of macromolecule metabolic process;regionalization;regulation of RNA biosynthetic process;response to organic substance;regulation of cellular process;heterocycle metabolic process;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;aromatic compound biosynthetic process;cellular macromolecule biosynthetic process;regulation of signaling;nitrogen compound metabolic process;embryonic axis specification;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;anterior/posterior axis specification;response to endogenous stimulus;biological regulation;transcription from RNA polymerase II promoter;regulation of biological quality;heterocycle biosynthetic process;embryonic pattern specification;transport;regulation of biosynthetic process;cellular response to organic substance;neurotrophin production;biological_process;metabolic process;neurotrophin TRK receptor signaling pathway;tripartite regional subdivision;blastoderm segmentation;zygotic determination of anterior/posterior axis, embryo;RNA metabolic process;secretion;cellular nitrogen compound biosynthetic process;anterior/posterior pattern specification;protein maturation;response to stimulus;biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;peptide metabolic process;response to BMP;cellular response to BMP stimulus;RNA biosynthetic process;embryo development;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;specification of symmetry;axis specification;regulation of cell communication;single-organism process;nucleobase-containing compound metabolic process;regulation of cellular response to growth factor stimulus;establishment of localization;proteolysis;developmental process;multicellular organismal process;regulation of macromolecule biosynthetic process;regulation of cellular metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;protein processing;peptide hormone processing;cellular response to growth factor stimulus;cellular amide metabolic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;secretion by cell;nucleobase-containing compound biosynthetic process;cellular response to endogenous stimulus;regulation of cellular biosynthetic process;nerve growth factor production;nucleic acid metabolic process;segmentation;glycoprotein metabolic process;multicellular organism development;pattern specification process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of nucleobase-containing compound metabolic process;regulation of hormone levels;single-organism developmental process;anterior/posterior axis specification, embryo;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;localization;single-organism localization;primary metabolic process;anatomical structure development;cellular metabolic process;nerve growth factor processing;determination of bilateral symmetry;cellular biosynthetic process; 4;3;3;6;4;5;6;7;5;5;4;3;3;4;7;5;7;6;4;5;6;4;3;4;3;4;3;4;5;5;3;3;6;4;2;7;4;4;6;3;2;7;3;5;5;4;4;5;4;1;2;7;6;6;8;5;5;5;6;5;2;3;6;7;6;5;4;5;6;5;4;2;4;3;5;5;4;2;4;4;3;5;2;2;5;4;2;4;7;6;4;6;5;4;5;4;5;4;5;5;5;6;5;4;4;6;3;5;5;5;5;4;3;7;4;5;3;4;4;2;3;3;3;3;5;6;4; GO:0031974;GO:0005783;GO:0016020;GO:0005794;GO:0005796;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0031012;GO:0005737;GO:0009986;GO:0044464;GO:0005623;GO:0005622;GO:0005615;GO:0043226;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;endoplasmic reticulum;membrane;Golgi apparatus;Golgi lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;extracellular matrix;cytoplasm;cell surface;cell part;cell;intracellular;extracellular space;organelle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;2;4;5;4;3;3;2;2;3;3;4;3;3;4;2;4;3;2;2;3;3;2;1;4;2; GO:0004252;GO:0043121;GO:0017171;GO:0097367;GO:0005539;GO:0003674;GO:0005488;GO:0019838;GO:0016787;GO:0003824;GO:0048406;GO:0008233;GO:0008236;GO:0043167;GO:0008201;GO:0005515;GO:0004175;GO:1901681;GO:0070011;GO:0043168; serine-type endopeptidase activity;neurotrophin binding;serine hydrolase activity;carbohydrate derivative binding;glycosaminoglycan binding;molecular_function;binding;growth factor binding;hydrolase activity;catalytic activity;nerve growth factor binding;peptidase activity;serine-type peptidase activity;ion binding;heparin binding;protein binding;endopeptidase activity;sulfur compound binding;peptidase activity, acting on L-amino acid peptides;anion binding; 6;5;4;3;4;1;2;4;3;2;6;4;5;3;4;3;6;3;5;4; K08672 IPR000742;IPR023828;IPR009030;IPR000209;IPR010909;IPR002884;IPR034182;IPR023827;IPR022398;IPR008979;IPR032778;IPR009020;IPR006212;IPR015500;IPR032815; EGF-like domain;Peptidase S8, subtilisin, Ser-active site;Growth factor receptor cysteine-rich domain;Peptidase S8/S53 domain;PLAC;Proprotein convertase, P;Kexin/furin catalytic domain;Peptidase S8, subtilisin, Asp-active site;Peptidase S8, subtilisin, His-active site;Galactose-binding domain-like;Growth factor receptor domain 4;Protease propeptides/proteinase inhibitor I9;Furin-like repeat;Peptidase S8, subtilisin-related;Peptidase S8, pro-domain; nucleus Hs4505577 2020.0 O [O] Posttranslational modification, protein turnover, chaperones; Q5TGY3 AT-hook DNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=AHDC1 PE=1 SV=1 - [AHDC1_HUMAN] 0.985 1.368 1.014 1.023 0.913 0.67 0.72002924 nan 1.120481928 nan 0.74122807 nan 0.733844469 nan GO:0097159;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901363; organic cyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;heterocyclic compound binding; 3;1;2;4;5;3; K22592 IPR032757; Domain of unknown function DUF4683; nucleus P46439 Glutathione S-transferase Mu 5 OS=Homo sapiens OX=9606 GN=GSTM5 PE=1 SV=3 - [GSTM5_HUMAN] 0.97 0.849 1.223 1.037 0.897 1.601 1.142520612 nan 1.156075808 nan 1.440518257 nan 1.78483835 nan GO:0044249;GO:0009410;GO:0006807;GO:0070887;GO:0044699;GO:1901576;GO:0044710;GO:1901685;GO:1901687;GO:0071704;GO:0071466;GO:0006749;GO:0009987;GO:0051716;GO:0009058;GO:0044711;GO:0044763;GO:0008152;GO:0006805;GO:0042221;GO:0006575;GO:1901564;GO:0043603;GO:1901566;GO:0044272;GO:0034641;GO:0044237;GO:0006790;GO:0008150;GO:0006518;GO:0050896;GO:0044281; cellular biosynthetic process;response to xenobiotic stimulus;nitrogen compound metabolic process;cellular response to chemical stimulus;single-organism process;organic substance biosynthetic process;single-organism metabolic process;glutathione derivative metabolic process;glutathione derivative biosynthetic process;organic substance metabolic process;cellular response to xenobiotic stimulus;glutathione metabolic process;cellular process;cellular response to stimulus;biosynthetic process;single-organism biosynthetic process;single-organism cellular process;metabolic process;xenobiotic metabolic process;response to chemical;cellular modified amino acid metabolic process;organonitrogen compound metabolic process;cellular amide metabolic process;organonitrogen compound biosynthetic process;sulfur compound biosynthetic process;cellular nitrogen compound metabolic process;cellular metabolic process;sulfur compound metabolic process;biological_process;peptide metabolic process;response to stimulus;small molecule metabolic process; 4;4;3;4;2;4;3;4;5;3;5;5;2;3;3;4;3;2;4;3;4;4;5;5;5;4;3;4;1;5;2;4; GO:0005623;GO:0005737;GO:0005829;GO:0044464;GO:0005622;GO:0005575;GO:0044444;GO:0044424; cell;cytoplasm;cytosol;cell part;intracellular;cellular_component;cytoplasmic part;intracellular part; 2;4;5;2;3;1;4;3; GO:0003674;GO:0004364;GO:0016765;GO:0016740;GO:0003824; molecular_function;glutathione transferase activity;transferase activity, transferring alkyl or aryl (other than methyl) groups;transferase activity;catalytic activity; 1;5;4;3;2; K00799 map00480;map00980;map00982;map05204; Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Chemical carcinogenesis; IPR012336;IPR004046;IPR010987;IPR003081;IPR004045; Thioredoxin-like fold;Glutathione S-transferase, C-terminal;Glutathione S-transferase, C-terminal-like;Glutathione S-transferase, Mu class;Glutathione S-transferase, N-terminal; cytosol Hs4504181 448.0 O [O] Posttranslational modification, protein turnover, chaperones; Q2VWP7 Protogenin OS=Homo sapiens OX=9606 GN=PRTG PE=2 SV=1 - [PRTG_HUMAN] 0.889 1.07 0.959 1.599 0.757 1.185 0.830841121 nan 2.112285337 nan 0.896261682 nan 1.565389696 nan GO:0032502;GO:0044767;GO:0032501;GO:0044707;GO:0007275;GO:0008150;GO:0044699;GO:0048856; developmental process;single-organism developmental process;multicellular organismal process;single-multicellular organism process;multicellular organism development;biological_process;single-organism process;anatomical structure development; 2;3;2;3;4;1;2;3; GO:0005615;GO:0016021;GO:0016020;GO:0005575;GO:0005576;GO:0044425;GO:0044421;GO:0031224; extracellular space;integral component of membrane;membrane;cellular_component;extracellular region;membrane part;extracellular region part;intrinsic component of membrane; 3;4;2;1;2;2;2;3; IPR003599;IPR003598;IPR013783;IPR013098;IPR007110;IPR003961;IPR033011; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;Immunoglobulin I-set;Immunoglobulin-like domain;Fibronectin type III;Protogenin; plasma membrane Hs19882241 646.0 T [T] Signal transduction mechanisms; Q7Z2K8 G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2 - [GRIN1_HUMAN] 0.822 1.032 1.043 0.995 1.193 1.393 0.796511628 nan 0.834031852 nan 1.010658915 nan 1.167644593 nan GO:0048666;GO:0030030;GO:0030154;GO:0048468;GO:0031175;GO:0007275;GO:0044699;GO:0048869;GO:0016043;GO:0071840;GO:0032502;GO:0032501;GO:0030182;GO:0009987;GO:0044767;GO:0008150;GO:0048731;GO:0022008;GO:0048699;GO:0044707;GO:0007399;GO:0048856;GO:0044763; neuron development;cell projection organization;cell differentiation;cell development;neuron projection development;multicellular organism development;single-organism process;cellular developmental process;cellular component organization;cellular component organization or biogenesis;developmental process;multicellular organismal process;neuron differentiation;cellular process;single-organism developmental process;biological_process;system development;neurogenesis;generation of neurons;single-multicellular organism process;nervous system development;anatomical structure development;single-organism cellular process; 5;4;5;4;5;4;2;4;3;2;2;2;6;2;3;1;4;6;7;3;5;3;3; GO:0044463;GO:0030426;GO:0071944;GO:0005886;GO:0016020;GO:0097458;GO:0043005;GO:0030427;GO:0042995;GO:0044464;GO:0005623;GO:0005575; cell projection part;growth cone;cell periphery;plasma membrane;membrane;neuron part;neuron projection;site of polarized growth;cell projection;cell part;cell;cellular_component; 3;4;3;3;2;3;4;3;3;2;2;1; IPR032745; G protein-regulated inducer of neurite outgrowth, C-terminal; nucleus Q9UGL1 Lysine-specific demethylase 5B OS=Homo sapiens OX=9606 GN=KDM5B PE=1 SV=3 - [KDM5B_HUMAN] 0.958 1.758 0.373 2.204 0.403 0.62 0.544937429 nan 5.46898263 nan 0.212172924 nan 1.538461538 nan GO:0080090;GO:0019222;GO:0051049;GO:0006139;GO:2000113;GO:2000831;GO:1901576;GO:1901362;GO:0071840;GO:0032774;GO:0044710;GO:0010605;GO:0010604;GO:0048869;GO:0046879;GO:0048511;GO:0035938;GO:0048513;GO:0030855;GO:0048518;GO:0048519;GO:0035937;GO:0042127;GO:0060255;GO:0003006;GO:0061458;GO:2001141;GO:0023061;GO:0050678;GO:0033599;GO:0010876;GO:0010033;GO:2000112;GO:0003008;GO:0070988;GO:0044700;GO:0044703;GO:0044702;GO:0044707;GO:0019538;GO:0009566;GO:0035929;GO:0007154;GO:0010558;GO:0010629;GO:0023052;GO:0016568;GO:0016569;GO:0009892;GO:0009893;GO:0009890;GO:0015850;GO:0019438;GO:0008284;GO:0050673;GO:0010628;GO:0048589;GO:0043170;GO:0050789;GO:0097659;GO:0044267;GO:0009653;GO:0044260;GO:0010646;GO:0044060;GO:0046483;GO:0044344;GO:0016043;GO:0016577;GO:0065007;GO:0016570;GO:0065008;GO:0060065;GO:0030879;GO:0018130;GO:0009887;GO:0033601;GO:0050793;GO:0006810;GO:0009889;GO:0051716;GO:0071310;GO:0043412;GO:0036211;GO:0008150;GO:0060603;GO:0008152;GO:2000861;GO:0034654;GO:0060763;GO:0050794;GO:0000003;GO:0016070;GO:1902679;GO:0046903;GO:0044271;GO:0007423;GO:0022414;GO:0050896;GO:2000864;GO:0006355;GO:0010556;GO:0071774;GO:0051046;GO:0060986;GO:0043010;GO:0051240;GO:0051239;GO:0006869;GO:0034720;GO:0034721;GO:0030154;GO:0019953;GO:0033598;GO:0070848;GO:0009791;GO:0044249;GO:0034641;GO:1903530;GO:0070887;GO:0023051;GO:0044699;GO:0009719;GO:0051234;GO:0050886;GO:0044057;GO:0031327;GO:0060443;GO:0060444;GO:0061038;GO:0022612;GO:0060560;GO:0009888;GO:0071495;GO:0032501;GO:0035239;GO:0008283;GO:0009987;GO:0070306;GO:1903506;GO:1903507;GO:0009058;GO:0060992;GO:0034645;GO:0046883;GO:0001654;GO:0007338;GO:0060562;GO:0032879;GO:0051276;GO:0033036;GO:0071363;GO:0050679;GO:0070076;GO:0051094;GO:0051253;GO:0051252;GO:0032940;GO:0001763;GO:0048731;GO:0048732;GO:0061180;GO:0032502;GO:0060341;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0048754;GO:0006807;GO:0090304;GO:0008214;GO:0002088;GO:0048608;GO:0007275;GO:0002009;GO:0006482;GO:0040007;GO:0006325;GO:1901360;GO:0009636;GO:1902589;GO:0071704;GO:0010467;GO:0048729;GO:0071702;GO:0051704;GO:0010468;GO:0006351;GO:0060429;GO:0045934;GO:0061138;GO:0019219;GO:0006725;GO:0006464;GO:0010817;GO:0044767;GO:0032368;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007267;GO:0042221;GO:0035295;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0048856;GO:0044237;GO:0009914;GO:2000026;GO:0045892;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;regulation of transport;nucleobase-containing compound metabolic process;negative regulation of cellular macromolecule biosynthetic process;regulation of steroid hormone secretion;organic substance biosynthetic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;RNA biosynthetic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular developmental process;hormone secretion;rhythmic process;estradiol secretion;animal organ development;epithelial cell differentiation;positive regulation of biological process;negative regulation of biological process;estrogen secretion;regulation of cell proliferation;regulation of macromolecule metabolic process;developmental process involved in reproduction;reproductive system development;regulation of RNA biosynthetic process;signal release;regulation of epithelial cell proliferation;regulation of mammary gland epithelial cell proliferation;lipid localization;response to organic substance;regulation of cellular macromolecule biosynthetic process;system process;demethylation;single organism signaling;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;protein metabolic process;fertilization;steroid hormone secretion;cell communication;negative regulation of macromolecule biosynthetic process;negative regulation of gene expression;signaling;chromatin modification;covalent chromatin modification;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;organic hydroxy compound transport;aromatic compound biosynthetic process;positive regulation of cell proliferation;epithelial cell proliferation;positive regulation of gene expression;developmental growth;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;regulation of cell communication;regulation of endocrine process;heterocycle metabolic process;cellular response to fibroblast growth factor stimulus;cellular component organization;histone demethylation;biological regulation;histone modification;regulation of biological quality;uterus development;mammary gland development;heterocycle biosynthetic process;organ morphogenesis;positive regulation of mammary gland epithelial cell proliferation;regulation of developmental process;transport;regulation of biosynthetic process;cellular response to stimulus;cellular response to organic substance;macromolecule modification;protein modification process;biological_process;mammary gland duct morphogenesis;metabolic process;regulation of estrogen secretion;nucleobase-containing compound biosynthetic process;mammary duct terminal end bud growth;regulation of cellular process;reproduction;RNA metabolic process;negative regulation of RNA biosynthetic process;secretion;cellular nitrogen compound biosynthetic process;sensory organ development;reproductive process;response to stimulus;regulation of estradiol secretion;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;response to fibroblast growth factor;regulation of secretion;endocrine hormone secretion;camera-type eye development;positive regulation of multicellular organismal process;regulation of multicellular organismal process;lipid transport;histone H3-K4 demethylation;histone H3-K4 demethylation, trimethyl-H3-K4-specific;cell differentiation;sexual reproduction;mammary gland epithelial cell proliferation;response to growth factor;post-embryonic development;cellular biosynthetic process;cellular nitrogen compound metabolic process;regulation of secretion by cell;cellular response to chemical stimulus;regulation of signaling;single-organism process;response to endogenous stimulus;establishment of localization;endocrine process;regulation of system process;negative regulation of cellular biosynthetic process;mammary gland morphogenesis;branching involved in mammary gland duct morphogenesis;uterus morphogenesis;gland morphogenesis;developmental growth involved in morphogenesis;tissue development;cellular response to endogenous stimulus;multicellular organismal process;tube morphogenesis;cell proliferation;cellular process;lens fiber cell differentiation;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;biosynthetic process;response to fungicide;cellular macromolecule biosynthetic process;regulation of hormone secretion;eye development;single fertilization;epithelial tube morphogenesis;regulation of localization;chromosome organization;macromolecule localization;cellular response to growth factor stimulus;positive regulation of epithelial cell proliferation;histone lysine demethylation;positive regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;secretion by cell;morphogenesis of a branching structure;system development;gland development;mammary gland epithelium development;developmental process;regulation of cellular localization;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;branching morphogenesis of an epithelial tube;nitrogen compound metabolic process;nucleic acid metabolic process;protein dealkylation;lens development in camera-type eye;reproductive structure development;multicellular organism development;morphogenesis of an epithelium;protein demethylation;growth;chromatin organization;organic cyclic compound metabolic process;response to toxic substance;single-organism organelle organization;organic substance metabolic process;gene expression;tissue morphogenesis;organic substance transport;multi-organism process;regulation of gene expression;transcription, DNA-templated;epithelium development;negative regulation of nucleobase-containing compound metabolic process;morphogenesis of a branching epithelium;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;cellular protein modification process;regulation of hormone levels;single-organism developmental process;regulation of lipid transport;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell-cell signaling;response to chemical;tube development;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;anatomical structure development;cellular metabolic process;hormone transport;regulation of multicellular organismal development;negative regulation of transcription, DNA-templated;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;4;6;5;4;5;2;6;3;4;4;4;6;2;6;4;6;2;2;7;4;4;3;5;6;5;5;5;4;4;6;3;4;3;3;3;3;4;4;6;4;5;5;2;6;7;3;3;4;5;5;4;4;5;3;4;2;7;5;3;4;4;5;4;5;3;5;2;4;3;4;5;5;4;4;3;4;4;3;5;5;5;1;6;2;6;5;5;3;2;5;6;5;5;4;2;2;7;6;5;4;5;5;6;3;3;5;7;8;5;3;5;5;4;4;4;5;4;3;2;3;3;4;4;5;6;6;4;5;4;4;4;2;4;3;2;5;7;7;3;5;5;4;5;5;5;3;5;3;6;5;6;3;5;5;4;4;4;4;6;2;4;4;5;4;4;5;3;5;7;4;4;4;5;4;2;5;4;4;4;3;5;4;5;2;5;6;5;5;5;5;4;6;4;3;5;4;5;3;4;4;4;3;4;2;3;3;4;3;3;3;5;4;6;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0043229;GO:0043227;GO:0005654;GO:0005737;GO:0044446;GO:0044422;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0070013;GO:0043226;GO:0005575; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;intracellular organelle;membrane-bounded organelle;nucleoplasm;cytoplasm;intracellular organelle part;organelle part;nucleus;cell part;cell;intracellular;intracellular organelle lumen;organelle;cellular_component; 2;5;4;3;4;3;3;3;5;4;3;2;5;2;2;3;4;2;1; GO:0008270;GO:1901363;GO:0003714;GO:0003712;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0000988;GO:0003824;GO:0097159;GO:0051213;GO:0034647;GO:0034648;GO:0016491;GO:0043169;GO:0016706;GO:0016705;GO:0043167;GO:0001071;GO:0046914;GO:0003700;GO:0032451;GO:0032452;GO:0032453; zinc ion binding;heterocyclic compound binding;transcription corepressor activity;transcription cofactor activity;metal ion binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;catalytic activity;organic cyclic compound binding;dioxygenase activity;histone demethylase activity (H3-trimethyl-K4 specific);histone demethylase activity (H3-dimethyl-K4 specific);oxidoreductase activity;cation binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;ion binding;nucleic acid binding transcription factor activity;transition metal ion binding;transcription factor activity, sequence-specific DNA binding;demethylase activity;histone demethylase activity;histone demethylase activity (H3-K4 specific); 7;3;5;4;5;1;2;4;5;3;2;2;3;4;6;6;3;4;5;4;3;2;6;3;3;4;5; K11446 IPR003349;IPR019787;IPR019786;IPR004198;IPR011011;IPR013083;IPR003347;IPR001606;IPR001965;IPR013637; JmjN domain;Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;Zinc finger, C5HC2-type;Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;JmjC domain;ARID DNA-binding domain;Zinc finger, PHD-type;Lysine-specific demethylase-like domain; nucleus Hs19923370 3193.0 R [R] General function prediction only; Q96MR6 Cilia- and flagella-associated protein 57 OS=Homo sapiens OX=9606 GN=CFAP57 PE=2 SV=3 - [CFA57_HUMAN] 1.14 1.079 1.067 0.979 0.892 1.032 1.056533828 0.897329431 1.097533632 0.134975849 0.988878591 0.336373518 1.156950673 0.158289013 IPR001680;IPR017986;IPR015943;IPR011047; WD40 repeat;WD40-repeat-containing domain;WD40/YVTN repeat-like-containing domain;Quinoprotein alcohol dehydrogenase-like superfamily; cytosol Hs22042827 1095.0 S [S] Function unknown; Q9NUY8 TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3 - [TBC23_HUMAN] 1.132 1.092 0.843 1.19 1.091 0.672 1.036630037 nan 1.090742438 nan 0.771978022 nan 0.615948671 nan GO:0006954;GO:0032101;GO:0048583;GO:0009611;GO:1903555;GO:0050789;GO:0044699;GO:0032640;GO:0001817;GO:0051240;GO:0050727;GO:0071706;GO:0065007;GO:0031347;GO:0048518;GO:1903034;GO:0032675;GO:0032501;GO:0032635;GO:0006952;GO:0006950;GO:0008150;GO:0051239;GO:0044707;GO:0009605;GO:0080134;GO:0001816;GO:0032680;GO:0050896;GO:0032755;GO:0001819; inflammatory response;regulation of response to external stimulus;regulation of response to stimulus;response to wounding;regulation of tumor necrosis factor superfamily cytokine production;regulation of biological process;single-organism process;tumor necrosis factor production;regulation of cytokine production;positive regulation of multicellular organismal process;regulation of inflammatory response;tumor necrosis factor superfamily cytokine production;biological regulation;regulation of defense response;positive regulation of biological process;regulation of response to wounding;regulation of interleukin-6 production;multicellular organismal process;interleukin-6 production;defense response;response to stress;biological_process;regulation of multicellular organismal process;single-multicellular organism process;response to external stimulus;regulation of response to stress;cytokine production;regulation of tumor necrosis factor production;response to stimulus;positive regulation of interleukin-6 production;positive regulation of cytokine production; 5;4;3;4;5;2;2;6;4;3;5;5;2;5;2;5;5;2;5;4;3;1;3;3;3;4;4;6;2;5;4; K22555 IPR000195;IPR001763; Rab-GTPase-TBC domain;Rhodanese-like domain; cytosol Hs8922842 1400.0 R [R] General function prediction only; P18206 Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4 - [VINC_HUMAN] 0.682 0.972 1.344 0.864 1.355 0.658 0.701646091 nan 0.637638376 nan 1.382716049 nan 0.485608856 nan GO:0048675;GO:0008104;GO:0007599;GO:0045216;GO:0048589;GO:0048588;GO:0007596;GO:0048468;GO:0007160;GO:0003012;GO:0051641;GO:0071840;GO:0007409;GO:0070727;GO:0048869;GO:0009611;GO:0048519;GO:0031589;GO:1990138;GO:0006936;GO:0030168;GO:0016192;GO:0016477;GO:0044707;GO:0048870;GO:0050789;GO:0033036;GO:0022607;GO:0030336;GO:0006928;GO:0031175;GO:0000904;GO:0016049;GO:0000902;GO:0006887;GO:0016043;GO:0045055;GO:0065007;GO:0065008;GO:0006810;GO:0061564;GO:0098609;GO:0003008;GO:0009888;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0051234;GO:0046903;GO:0050896;GO:0001775;GO:0048812;GO:2000145;GO:2000146;GO:0030154;GO:0007043;GO:0009653;GO:0044699;GO:0034394;GO:0034333;GO:0030031;GO:0060560;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0051271;GO:0040012;GO:0098602;GO:0090136;GO:0032879;GO:0034329;GO:0032990;GO:0022610;GO:0032940;GO:0051674;GO:0048731;GO:0016337;GO:0030030;GO:0034332;GO:0030032;GO:0034330;GO:0040013;GO:0007275;GO:0002009;GO:0040007;GO:0002576;GO:0032989;GO:0048729;GO:0048666;GO:0048667;GO:0060429;GO:0030182;GO:0034109;GO:0034613;GO:0030334;GO:0044767;GO:0044765;GO:0044763;GO:0097581;GO:0007155;GO:0022008;GO:0051179;GO:1902578;GO:0040011;GO:0048699;GO:0051270;GO:0048858;GO:0007399;GO:0048856;GO:0043297;GO:0044085;GO:0070527;GO:0048523; axon extension;protein localization;hemostasis;cell-cell junction organization;developmental growth;developmental cell growth;blood coagulation;cell development;cell-matrix adhesion;muscle system process;cellular localization;cellular component organization or biogenesis;axonogenesis;cellular macromolecule localization;cellular developmental process;response to wounding;negative regulation of biological process;cell-substrate adhesion;neuron projection extension;muscle contraction;platelet activation;vesicle-mediated transport;cell migration;single-multicellular organism process;cell motility;regulation of biological process;macromolecule localization;cellular component assembly;negative regulation of cell migration;movement of cell or subcellular component;neuron projection development;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;exocytosis;cellular component organization;regulated exocytosis;biological regulation;regulation of biological quality;transport;axon development;cell-cell adhesion;system process;tissue development;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;establishment of localization;secretion;response to stimulus;cell activation;neuron projection morphogenesis;regulation of cell motility;negative regulation of cell motility;cell differentiation;cell-cell junction assembly;anatomical structure morphogenesis;single-organism process;protein localization to cell surface;adherens junction assembly;cell projection assembly;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;negative regulation of cellular component movement;regulation of locomotion;single organism cell adhesion;epithelial cell-cell adhesion;regulation of localization;cell junction assembly;cell part morphogenesis;biological adhesion;secretion by cell;localization of cell;system development;single organismal cell-cell adhesion;cell projection organization;adherens junction organization;lamellipodium assembly;cell junction organization;negative regulation of locomotion;multicellular organism development;morphogenesis of an epithelium;growth;platelet degranulation;cellular component morphogenesis;tissue morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;epithelium development;neuron differentiation;homotypic cell-cell adhesion;cellular protein localization;regulation of cell migration;single-organism developmental process;single-organism transport;single-organism cellular process;lamellipodium organization;cell adhesion;neurogenesis;localization;single-organism localization;locomotion;generation of neurons;regulation of cellular component movement;cell projection morphogenesis;nervous system development;anatomical structure development;apical junction assembly;cellular component biogenesis;platelet aggregation;negative regulation of cellular process; 6;4;5;5;3;4;5;4;5;4;3;2;7;4;4;4;2;4;5;5;5;5;4;3;3;2;3;4;5;4;5;5;3;5;5;3;6;2;3;4;6;4;3;4;5;3;3;4;1;3;5;2;4;6;4;4;5;6;3;2;6;6;5;4;2;2;4;2;4;3;3;5;3;5;5;2;4;3;4;4;4;6;6;4;3;4;5;2;7;4;4;5;6;5;6;5;5;5;3;4;3;5;3;6;2;3;2;7;4;5;5;3;7;3;6;3; GO:0030057;GO:0030055;GO:0031982;GO:0016020;GO:0098862;GO:0044291;GO:0098589;GO:0098805;GO:0043234;GO:0043230;GO:0043232;GO:0005829;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0099568;GO:0043229;GO:0043228;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0030054;GO:1990357;GO:0070161;GO:0005938;GO:0030863;GO:0030864;GO:0044446;GO:0044444;GO:0044422;GO:0044448;GO:0044449;GO:0030016;GO:0005903;GO:0005737;GO:0043034;GO:0005916;GO:0005915;GO:0005913;GO:0005912;GO:0005911;GO:0090636;GO:0090637;GO:0044464;GO:0005623;GO:0005622;GO:0045121;GO:0015629;GO:0014704;GO:0071944;GO:0005576;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0043292;GO:0043296; desmosome;cell-substrate junction;vesicle;membrane;cluster of actin-based cell projections;cell-cell contact zone;membrane region;whole membrane;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;membrane part;membrane microdomain;extracellular region part;cytoplasmic region;intracellular organelle;non-membrane-bounded organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;cell junction;terminal web;anchoring junction;cell cortex;cortical cytoskeleton;cortical actin cytoskeleton;intracellular organelle part;cytoplasmic part;organelle part;cell cortex part;contractile fiber part;myofibril;brush border;cytoplasm;costamere;fascia adherens;zonula adherens;cell-cell adherens junction;adherens junction;cell-cell junction;outer dense plaque of desmosome;inner dense plaque of desmosome;cell part;cell;intracellular;membrane raft;actin cytoskeleton;intercalated disc;cell periphery;extracellular region;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;contractile fiber;apical junction complex; 4;3;4;2;3;4;3;3;3;3;4;5;3;2;4;2;5;3;3;4;5;3;2;5;4;2;6;3;4;6;5;3;4;2;5;3;6;4;4;4;5;5;4;4;3;3;3;2;2;3;5;6;5;3;2;3;3;4;2;1;5;4; GO:0005198;GO:0045296;GO:0031625;GO:0050839;GO:0097367;GO:0045294;GO:0003674;GO:0005488;GO:0003779;GO:0001948;GO:0008013;GO:0008092;GO:0019899;GO:0044389;GO:0005515;GO:0002162; structural molecule activity;cadherin binding;ubiquitin protein ligase binding;cell adhesion molecule binding;carbohydrate derivative binding;alpha-catenin binding;molecular_function;binding;actin binding;glycoprotein binding;beta-catenin binding;cytoskeletal protein binding;enzyme binding;ubiquitin-like protein ligase binding;protein binding;dystroglycan binding; 2;5;6;4;3;4;1;2;5;4;4;4;4;5;3;5; K05700 map04510;map04520;map04670;map04810;map05100;map05131;map05146; Focal adhesion;Adherens junction;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Amoebiasis; IPR017997;IPR006077;IPR000633; Vinculin;Vinculin/alpha-catenin;Vinculin, conserved site; cytosol Hs7669550 2313.0 W [W] Extracellular structures; P10314 HLA class I histocompatibility antigen, A-32 alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2 - [1A32_HUMAN] 1.049 0.903 0.86 1.09 1.263 1.233 1.161683278 nan 0.863024545 nan 0.952380952 nan 0.976247031 nan GO:0048585;GO:0048583;GO:0002707;GO:0002706;GO:0002704;GO:0002703;GO:0007165;GO:0007166;GO:0031341;GO:0031342;GO:0031347;GO:0019221;GO:0051716;GO:0044419;GO:0001909;GO:0065007;GO:0001906;GO:0002480;GO:0060337;GO:0010033;GO:0051704;GO:0044700;GO:0031348;GO:0002376;GO:0001911;GO:0001910;GO:0048002;GO:0050789;GO:0071357;GO:0045824;GO:0002682;GO:0002683;GO:0019882;GO:0019884;GO:0034097;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0042269;GO:0060333;GO:0071345;GO:0050896;GO:0042267;GO:0002697;GO:0002698;GO:0006955;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0042270;GO:0002228;GO:0009987;GO:0048519;GO:0050777;GO:0050776;GO:0080134;GO:0071346;GO:0042590;GO:0002474;GO:0002479;GO:0002478;GO:0071310;GO:0045953;GO:0045088;GO:0045087;GO:0034340;GO:0034341;GO:0002449;GO:0044764;GO:0044763;GO:0002715;GO:0002716;GO:0007154;GO:0002443;GO:0016032;GO:0002252;GO:0044403; negative regulation of response to stimulus;regulation of response to stimulus;negative regulation of lymphocyte mediated immunity;regulation of lymphocyte mediated immunity;negative regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;signal transduction;cell surface receptor signaling pathway;regulation of cell killing;negative regulation of cell killing;regulation of defense response;cytokine-mediated signaling pathway;cellular response to stimulus;interspecies interaction between organisms;leukocyte mediated cytotoxicity;biological regulation;cell killing;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;type I interferon signaling pathway;response to organic substance;multi-organism process;single organism signaling;negative regulation of defense response;immune system process;negative regulation of leukocyte mediated cytotoxicity;regulation of leukocyte mediated cytotoxicity;antigen processing and presentation of peptide antigen;regulation of biological process;cellular response to type I interferon;negative regulation of innate immune response;regulation of immune system process;negative regulation of immune system process;antigen processing and presentation;antigen processing and presentation of exogenous antigen;response to cytokine;regulation of cellular process;defense response;response to stress;biological_process;regulation of natural killer cell mediated cytotoxicity;interferon-gamma-mediated signaling pathway;cellular response to cytokine stimulus;response to stimulus;natural killer cell mediated cytotoxicity;regulation of immune effector process;negative regulation of immune effector process;immune response;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;protection from natural killer cell mediated cytotoxicity;natural killer cell mediated immunity;cellular process;negative regulation of biological process;negative regulation of immune response;regulation of immune response;regulation of response to stress;cellular response to interferon-gamma;antigen processing and presentation of exogenous peptide antigen via MHC class I;antigen processing and presentation of peptide antigen via MHC class I;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen;cellular response to organic substance;negative regulation of natural killer cell mediated cytotoxicity;regulation of innate immune response;innate immune response;response to type I interferon;response to interferon-gamma;lymphocyte mediated immunity;multi-organism cellular process;single-organism cellular process;regulation of natural killer cell mediated immunity;negative regulation of natural killer cell mediated immunity;cell communication;leukocyte mediated immunity;viral process;immune effector process;symbiosis, encompassing mutualism through parasitism; 3;3;6;6;5;5;4;5;3;3;5;6;3;3;3;2;2;7;7;4;2;3;4;2;4;4;4;2;6;5;3;3;3;4;5;3;4;3;1;4;7;6;2;3;4;4;3;2;4;3;2;5;5;2;2;4;4;4;6;6;5;7;5;5;4;5;4;5;5;5;3;3;6;6;4;4;4;3;4; GO:0005783;GO:0098576;GO:0005789;GO:0031224;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0071556;GO:0031988;GO:0031901;GO:0005794;GO:0098588;GO:0042611;GO:0042612;GO:0043231;GO:0044437;GO:0044424;GO:0031301;GO:0044422;GO:0043229;GO:0030176;GO:0043227;GO:0044433;GO:0044432;GO:0044431;GO:0030666;GO:0012505;GO:0012506;GO:0012507;GO:0030670;GO:0045335;GO:0000139;GO:0044446;GO:0005773;GO:0044444;GO:0044440;GO:0097708;GO:0042175;GO:0031300;GO:0005774;GO:0031227;GO:0010008;GO:0005737;GO:0031090;GO:0030662;GO:0031410;GO:0098797;GO:0044459;GO:0009986;GO:0030658;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0030139;GO:0071944;GO:0098553;GO:0098552;GO:0030133;GO:0030135;GO:0030134;GO:0098805;GO:0043226;GO:0043234;GO:0044425;GO:0005886;GO:0032991;GO:0005575;GO:0098796;GO:0005768;GO:0005769; endoplasmic reticulum;lumenal side of membrane;endoplasmic reticulum membrane;intrinsic component of membrane;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;integral component of lumenal side of endoplasmic reticulum membrane;membrane-bounded vesicle;early endosome membrane;Golgi apparatus;bounding membrane of organelle;MHC protein complex;MHC class I protein complex;intracellular membrane-bounded organelle;vacuolar part;intracellular part;integral component of organelle membrane;organelle part;intracellular organelle;integral component of endoplasmic reticulum membrane;membrane-bounded organelle;cytoplasmic vesicle part;endoplasmic reticulum part;Golgi apparatus part;endocytic vesicle membrane;endomembrane system;vesicle membrane;ER to Golgi transport vesicle membrane;phagocytic vesicle membrane;phagocytic vesicle;Golgi membrane;intracellular organelle part;vacuole;cytoplasmic part;endosomal part;intracellular vesicle;nuclear outer membrane-endoplasmic reticulum membrane network;intrinsic component of organelle membrane;vacuolar membrane;intrinsic component of endoplasmic reticulum membrane;endosome membrane;cytoplasm;organelle membrane;coated vesicle membrane;cytoplasmic vesicle;plasma membrane protein complex;plasma membrane part;cell surface;transport vesicle membrane;cytoplasmic vesicle membrane;cell part;cell;intracellular;endocytic vesicle;cell periphery;lumenal side of endoplasmic reticulum membrane;side of membrane;transport vesicle;coated vesicle;ER to Golgi transport vesicle;whole membrane;organelle;protein complex;membrane part;plasma membrane;macromolecular complex;cellular_component;membrane protein complex;endosome;early endosome; 4;3;3;3;4;5;4;2;5;5;6;4;4;5;6;4;4;3;4;2;3;4;3;4;4;4;4;3;4;5;5;7;5;3;5;4;5;4;3;3;4;4;5;4;3;4;5;4;3;3;4;5;2;2;3;6;3;4;3;4;6;5;3;2;3;2;3;2;1;3;4;5; GO:0046977;GO:0042605;GO:0003674;GO:0005488;GO:0030881;GO:0003823;GO:0042277;GO:0033218;GO:0005515; TAP binding;peptide antigen binding;molecular_function;binding;beta-2-microglobulin binding;antigen binding;peptide binding;amide binding;protein binding; 4;4;1;2;4;3;4;3;3; K06751 map04144;map04145;map04514;map04612;map04940;map05166;map05168;map05169;map05203;map05320;map05330;map05332;map05416; Endocytosis;Phagosome;Cell adhesion molecules (CAMs);Antigen processing and presentation;Type I diabetes mellitus;HTLV-I infection;Herpes simplex infection;Epstein-Barr virus infection;Viral carcinogenesis;Autoimmune thyroid disease;Allograft rejection;Graft-versus-host disease;Viral myocarditis; IPR007110;IPR013783;IPR001039;IPR003597;IPR010579;IPR003006;IPR011162;IPR011161; Immunoglobulin-like domain;Immunoglobulin-like fold;MHC class I alpha chain, alpha1 alpha2 domains;Immunoglobulin C1-set;MHC class I, alpha chain, C-terminal;Immunoglobulin/major histocompatibility complex, conserved site;MHC classes I/II-like antigen recognition protein;MHC class I-like antigen recognition-like; extracellular Q8IWJ2 GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4 - [GCC2_HUMAN] 1.049 0.956 0.992 1.218 0.948 1.233 1.097280335 nan 1.284810127 nan 1.037656904 nan 1.300632911 nan GO:0033157;GO:0008104;GO:0051049;GO:0032386;GO:0071840;GO:0070727;GO:0010256;GO:0090161;GO:0033036;GO:0006605;GO:0045184;GO:0050794;GO:0016197;GO:0016192;GO:0034067;GO:0000301;GO:0000226;GO:0051223;GO:0070861;GO:0006886;GO:0016043;GO:0065007;GO:0070201;GO:1903649;GO:0006810;GO:0006622;GO:0006623;GO:0008150;GO:0042147;GO:0051234;GO:0034499;GO:0006891;GO:0046907;GO:0072666;GO:0072665;GO:1903827;GO:0007041;GO:0044699;GO:0032880;GO:0000042;GO:0031023;GO:0072594;GO:0009987;GO:0061462;GO:0071955;GO:0032879;GO:0016482;GO:0007030;GO:0007034;GO:0033365;GO:0060341;GO:0072600;GO:0050789;GO:0071702;GO:0034453;GO:0032527;GO:0048193;GO:0034613;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0007017;GO:0007010;GO:1902589;GO:0015031;GO:1902582;GO:1902580; regulation of intracellular protein transport;protein localization;regulation of transport;regulation of intracellular transport;cellular component organization or biogenesis;cellular macromolecule localization;endomembrane system organization;Golgi ribbon formation;macromolecule localization;protein targeting;establishment of protein localization;regulation of cellular process;endosomal transport;vesicle-mediated transport;protein localization to Golgi apparatus;retrograde transport, vesicle recycling within Golgi;microtubule cytoskeleton organization;regulation of protein transport;regulation of protein exit from endoplasmic reticulum;intracellular protein transport;cellular component organization;biological regulation;regulation of establishment of protein localization;regulation of cytoplasmic transport;transport;protein targeting to lysosome;protein targeting to vacuole;biological_process;retrograde transport, endosome to Golgi;establishment of localization;late endosome to Golgi transport;intra-Golgi vesicle-mediated transport;intracellular transport;establishment of protein localization to vacuole;protein localization to vacuole;regulation of cellular protein localization;lysosomal transport;single-organism process;regulation of protein localization;protein targeting to Golgi;microtubule organizing center organization;establishment of protein localization to organelle;cellular process;protein localization to lysosome;recycling endosome to Golgi transport;regulation of localization;cytosolic transport;Golgi organization;vacuolar transport;protein localization to organelle;regulation of cellular localization;establishment of protein localization to Golgi;regulation of biological process;organic substance transport;microtubule anchoring;protein exit from endoplasmic reticulum;Golgi vesicle transport;cellular protein localization;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;microtubule-based process;cytoskeleton organization;single-organism organelle organization;protein transport;single-organism intracellular transport;single-organism cellular localization; 6;4;4;5;2;4;4;6;3;6;4;3;7;5;7;8;5;5;7;6;3;2;5;6;4;6;5;1;6;3;7;7;5;6;7;5;7;2;4;5;5;5;2;8;7;3;6;5;6;6;4;6;2;5;6;6;6;5;4;3;4;2;3;3;4;4;5;4;5;5;4; GO:0031984;GO:0016020;GO:0005794;GO:0043231;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005802;GO:0005575;GO:0098791; organelle subcompartment;membrane;Golgi apparatus;intracellular membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;trans-Golgi network;cellular_component;Golgi subcompartment; 4;2;4;4;3;2;3;3;2;4;3;3;4;4;2;2;3;5;1;5; GO:0005488;GO:0042802;GO:0005515;GO:0003674; binding;identical protein binding;protein binding;molecular_function; 2;4;3;1; K20282 IPR032023;IPR000237; GCC2, Rab binding domain;GRIP domain; cytosol Q9HCE6 Rho guanine nucleotide exchange factor 10-like protein OS=Homo sapiens OX=9606 GN=ARHGEF10L PE=1 SV=4 - [ARGAL_HUMAN] 1.202 0.731 1.325 1.014 0.934 11.063 1.644322845 0.080043307 1.085653105 0.571402515 1.812585499 0.066545547 11.84475375 nan GO:0023051;GO:0007165;GO:1902531;GO:0035023;GO:0035556;GO:0010646;GO:0050789;GO:0044699;GO:0051716;GO:0009966;GO:0065007;GO:0051056;GO:0046578;GO:0009987;GO:0048583;GO:0050794;GO:0008150;GO:0007266;GO:0007265;GO:0007264;GO:0044700;GO:0050896;GO:0044763;GO:0007154;GO:0023052; regulation of signaling;signal transduction;regulation of intracellular signal transduction;regulation of Rho protein signal transduction;intracellular signal transduction;regulation of cell communication;regulation of biological process;single-organism process;cellular response to stimulus;regulation of signal transduction;biological regulation;regulation of small GTPase mediated signal transduction;regulation of Ras protein signal transduction;cellular process;regulation of response to stimulus;regulation of cellular process;biological_process;Rho protein signal transduction;Ras protein signal transduction;small GTPase mediated signal transduction;single organism signaling;response to stimulus;single-organism cellular process;cell communication;signaling; 3;4;5;8;5;4;2;2;3;4;2;6;7;2;3;3;1;8;7;6;3;2;3;4;2; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0005089;GO:0005088;GO:0005085;GO:0003674;GO:0098772; Rho guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;molecular_function;molecular function regulator; 5;4;3;1;2; K16727 IPR015943;IPR011993;IPR000219;IPR017986; WD40/YVTN repeat-like-containing domain;PH domain-like;Dbl homology (DH) domain;WD40-repeat-containing domain; nucleus Hs8922489 1185.0 T [T] Signal transduction mechanisms; A0A0A0MS15 Immunoglobulin heavy variable 3-49 OS=Homo sapiens OX=9606 GN=IGHV3-49 PE=3 SV=1 - [HV349_HUMAN] 0.949 1.283 0.577 0.863 1.38 1.29 0.739672642 0.007130158 0.625362319 4.36E-05 0.449727202 1.37E-11 0.934782609 0.305325359 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P17936 Insulin-like growth factor-binding protein 3 OS=Homo sapiens OX=9606 GN=IGFBP3 PE=1 SV=2 - [IBP3_HUMAN] 0.903 0.768 1.467 0.826 0.851 0.949 1.17578125 0.768234902 0.970622797 0.6493458 1.91015625 0.02147039 1.115158637 0.707273754 GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0001503;GO:0044281;GO:0007166;GO:0007167;GO:0007169;GO:0023014;GO:0051716;GO:0010605;GO:0009968;GO:0009967;GO:0071840;GO:0000165;GO:0045661;GO:0048869;GO:0044093;GO:0048518;GO:0048519;GO:0031324;GO:0042127;GO:0060255;GO:0016049;GO:0042325;GO:0044700;GO:0042327;GO:0042326;GO:0044707;GO:0048870;GO:0019538;GO:0033002;GO:0042692;GO:0007165;GO:0009892;GO:0009893;GO:0014812;GO:0006928;GO:0010906;GO:0048009;GO:0045445;GO:0035556;GO:0050789;GO:0044267;GO:0044262;GO:0045937;GO:0044260;GO:0044342;GO:0016043;GO:0050793;GO:0065007;GO:0043085;GO:0065009;GO:0016477;GO:0050790;GO:0019318;GO:0044710;GO:0050794;GO:0043410;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:1902533;GO:1902531;GO:0010604;GO:0051174;GO:0050896;GO:0031401;GO:0009966;GO:2000145;GO:0048659;GO:2000146;GO:0006109;GO:0010562;GO:0051246;GO:0016310;GO:0030154;GO:0051128;GO:0023056;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0061061;GO:0010647;GO:0010646;GO:0044699;GO:0043408;GO:0051248;GO:0043567;GO:0010563;GO:0043568;GO:0051247;GO:0050673;GO:0032270;GO:0031399;GO:0031325;GO:0032502;GO:0008285;GO:0014909;GO:0045663;GO:0008283;GO:0001558;GO:0009987;GO:0040013;GO:0045597;GO:0045595;GO:0051270;GO:0010675;GO:0032879;GO:0032269;GO:0032268;GO:0051094;GO:0005996;GO:0043170;GO:0051674;GO:0006006;GO:0031400;GO:0014910;GO:0014912;GO:0031323;GO:0051149;GO:0032501;GO:0051147;GO:0010942;GO:0008219;GO:0010941;GO:0001649;GO:0042981;GO:0040008;GO:0043065;GO:0071704;GO:0043067;GO:0043068;GO:0030336;GO:0006468;GO:0030334;GO:0048662;GO:0048660;GO:0045936;GO:0006915;GO:0006464;GO:0044767;GO:0044763;GO:0007154;GO:0051179;GO:0040007;GO:0040011;GO:0044238;GO:0051271;GO:0040012;GO:0005975;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:0001933;GO:0001932;GO:0001934;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;ossification;small molecule metabolic process;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;signal transduction by protein phosphorylation;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;regulation of myoblast differentiation;cellular developmental process;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;negative regulation of cellular metabolic process;regulation of cell proliferation;regulation of macromolecule metabolic process;cell growth;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;negative regulation of phosphorylation;single-multicellular organism process;cell motility;protein metabolic process;muscle cell proliferation;muscle cell differentiation;signal transduction;negative regulation of metabolic process;positive regulation of metabolic process;muscle cell migration;movement of cell or subcellular component;regulation of glucose metabolic process;insulin-like growth factor receptor signaling pathway;myoblast differentiation;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;cellular carbohydrate metabolic process;positive regulation of phosphate metabolic process;cellular macromolecule metabolic process;type B pancreatic cell proliferation;cellular component organization;regulation of developmental process;biological regulation;positive regulation of catalytic activity;regulation of molecular function;cell migration;regulation of catalytic activity;hexose metabolic process;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;positive regulation of macromolecule metabolic process;regulation of phosphorus metabolic process;response to stimulus;positive regulation of protein modification process;regulation of signal transduction;regulation of cell motility;smooth muscle cell proliferation;negative regulation of cell motility;regulation of carbohydrate metabolic process;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;phosphorylation;cell differentiation;regulation of cellular component organization;positive regulation of signaling;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;muscle structure development;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MAPK cascade;negative regulation of protein metabolic process;regulation of insulin-like growth factor receptor signaling pathway;negative regulation of phosphorus metabolic process;positive regulation of insulin-like growth factor receptor signaling pathway;positive regulation of protein metabolic process;epithelial cell proliferation;positive regulation of cellular protein metabolic process;regulation of protein modification process;positive regulation of cellular metabolic process;developmental process;negative regulation of cell proliferation;smooth muscle cell migration;positive regulation of myoblast differentiation;cell proliferation;regulation of cell growth;cellular process;negative regulation of locomotion;positive regulation of cell differentiation;regulation of cell differentiation;regulation of cellular component movement;regulation of cellular carbohydrate metabolic process;regulation of localization;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;positive regulation of developmental process;monosaccharide metabolic process;macromolecule metabolic process;localization of cell;glucose metabolic process;negative regulation of protein modification process;regulation of smooth muscle cell migration;negative regulation of smooth muscle cell migration;regulation of cellular metabolic process;positive regulation of muscle cell differentiation;multicellular organismal process;regulation of muscle cell differentiation;positive regulation of cell death;cell death;regulation of cell death;osteoblast differentiation;regulation of apoptotic process;regulation of growth;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;positive regulation of programmed cell death;negative regulation of cell migration;protein phosphorylation;regulation of cell migration;negative regulation of smooth muscle cell proliferation;regulation of smooth muscle cell proliferation;negative regulation of phosphate metabolic process;apoptotic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell communication;localization;growth;locomotion;primary metabolic process;negative regulation of cellular component movement;regulation of locomotion;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;3;3;3;4;4;5;6;7;4;3;4;4;4;2;5;6;4;4;2;2;4;4;4;3;7;3;7;7;3;3;4;4;5;4;3;3;5;4;6;8;6;5;2;5;4;6;4;5;3;3;2;5;3;4;4;6;3;3;6;5;5;5;1;2;4;5;5;4;5;2;6;4;4;5;4;5;5;5;6;5;4;3;3;2;4;3;4;4;4;2;6;5;5;5;5;5;4;5;6;4;2;4;6;6;3;4;2;3;4;4;4;5;3;5;5;3;5;4;3;7;6;6;6;4;5;2;5;4;4;4;5;6;3;6;3;5;5;5;7;5;5;5;6;6;6;3;3;4;2;2;2;3;4;3;4;3;3;5;4;7;7;7;3;3; GO:0031982;GO:0043234;GO:0043230;GO:0043231;GO:0036454;GO:0044424;GO:0044421;GO:0043229;GO:0005622;GO:0043227;GO:0016942;GO:0005615;GO:0005634;GO:0042567;GO:0032991;GO:0044464;GO:0005623;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576; vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;growth factor complex;intracellular part;extracellular region part;intracellular organelle;intracellular;membrane-bounded organelle;insulin-like growth factor binding protein complex;extracellular space;nucleus;insulin-like growth factor ternary complex;macromolecular complex;cell part;cell;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region; 4;3;3;4;4;3;2;3;3;3;3;3;5;4;2;2;2;4;2;3;1;2; GO:0098772;GO:0031994;GO:0072542;GO:0046872;GO:0005520;GO:0008160;GO:0003674;GO:0005488;GO:0019838;GO:0001968;GO:0019888;GO:0043169;GO:0043167;GO:0005515;GO:0019208;GO:0008047;GO:0019211;GO:0030234;GO:0031995; molecular function regulator;insulin-like growth factor I binding;protein phosphatase activator activity;metal ion binding;insulin-like growth factor binding;protein tyrosine phosphatase activator activity;molecular_function;binding;growth factor binding;fibronectin binding;protein phosphatase regulator activity;cation binding;ion binding;protein binding;phosphatase regulator activity;enzyme activator activity;phosphatase activator activity;enzyme regulator activity;insulin-like growth factor II binding; 2;6;6;5;5;7;1;2;4;4;5;4;3;3;4;4;5;3;6; K10138 map04115;map05202; p53 signaling pathway;Transcriptional misregulation in cancer; IPR012211;IPR009168;IPR022321;IPR000716;IPR017891;IPR009030;IPR000867; Insulin-like growth factor binding protein 3;Insulin-like growth factor binding protein;Insulin-like growth factor-binding protein family 1-6, chordata;Thyroglobulin type-1;Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site;Growth factor receptor cysteine-rich domain;Insulin-like growth factor-binding protein, IGFBP; extracellular Q92834 X-linked retinitis pigmentosa GTPase regulator OS=Homo sapiens OX=9606 GN=RPGR PE=1 SV=2 - [RPGR_HUMAN] 0.939 1.117 0.871 0.828 1.197 1.847 0.840644584 nan 0.691729323 nan 0.779767234 nan 1.543024227 nan GO:0008104;GO:0071840;GO:0070727;GO:0048869;GO:0098840;GO:0033036;GO:0007601;GO:0007600;GO:0045184;GO:0010970;GO:0003008;GO:0031503;GO:0044782;GO:0022607;GO:0006928;GO:0000902;GO:0006886;GO:0016043;GO:0048646;GO:0042384;GO:0060271;GO:0006810;GO:0050953;GO:0008150;GO:0051234;GO:0046907;GO:0050896;GO:0042073;GO:0010927;GO:0009653;GO:0044699;GO:0030705;GO:0032502;GO:0032501;GO:0050877;GO:0009987;GO:0048858;GO:0030030;GO:0030031;GO:0032989;GO:0071702;GO:0034613;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0070925;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0007017;GO:0032990;GO:0048856;GO:0007018;GO:1902589;GO:0044085;GO:0015031;GO:1902582; protein localization;cellular component organization or biogenesis;cellular macromolecule localization;cellular developmental process;protein transport along microtubule;macromolecule localization;visual perception;sensory perception;establishment of protein localization;establishment of localization by movement along microtubule;system process;protein complex localization;cilium organization;cellular component assembly;movement of cell or subcellular component;cell morphogenesis;intracellular protein transport;cellular component organization;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;transport;sensory perception of light stimulus;biological_process;establishment of localization;intracellular transport;response to stimulus;intraciliary transport;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;single-organism process;cytoskeleton-dependent intracellular transport;developmental process;multicellular organismal process;neurological system process;cellular process;cell projection morphogenesis;cell projection organization;cell projection assembly;cellular component morphogenesis;organic substance transport;cellular protein localization;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;organelle assembly;localization;single-organism localization;cellular localization;organelle organization;microtubule-based process;cell part morphogenesis;anatomical structure development;microtubule-based movement;single-organism organelle organization;cellular component biogenesis;protein transport;single-organism intracellular transport; 4;2;4;4;5;3;7;5;4;4;3;5;5;4;4;5;6;3;3;5;6;4;6;1;3;5;2;6;4;3;2;6;2;2;4;2;5;4;5;4;5;5;3;4;3;4;5;2;3;3;4;4;5;3;5;4;3;5;5; GO:0005815;GO:0031514;GO:0031513;GO:0005794;GO:0042995;GO:0001750;GO:0043231;GO:0043232;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0043227;GO:0043226;GO:0005856;GO:0036064;GO:0044430;GO:0012505;GO:0044446;GO:0044444;GO:0044441;GO:0005737;GO:0036126;GO:0097223;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0072372;GO:0005813;GO:0097458;GO:0015630;GO:0005575; microtubule organizing center;motile cilium;nonmotile primary cilium;Golgi apparatus;cell projection;photoreceptor outer segment;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;membrane-bounded organelle;organelle;cytoskeleton;ciliary basal body;cytoskeletal part;endomembrane system;intracellular organelle part;cytoplasmic part;ciliary part;cytoplasm;sperm flagellum;sperm part;cell projection part;cell part;cell;intracellular;primary cilium;centrosome;neuron part;microtubule cytoskeleton;cellular_component; 5;4;5;4;3;4;4;4;3;2;3;3;3;3;2;5;4;4;3;3;4;3;4;4;3;3;2;2;3;4;5;3;6;1; GO:1901363;GO:0005085;GO:0003674;GO:0005488;GO:0003676;GO:0098772;GO:0097159;GO:0044822;GO:0003723; heterocyclic compound binding;guanyl-nucleotide exchange factor activity;molecular_function;binding;nucleic acid binding;molecular function regulator;organic cyclic compound binding;poly(A) RNA binding;RNA binding; 3;3;1;2;4;2;3;6;5; K19607 IPR032994;IPR009091;IPR000408; X-linked retinitis pigmentosa GTPase regulator;Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;Regulator of chromosome condensation, RCC1; nucleus Hs4506581_1 1104.0 S [S] Function unknown; Q6ECI4 Zinc finger protein 470 OS=Homo sapiens OX=9606 GN=ZNF470 PE=2 SV=3 - [ZN470_HUMAN] 0.971 0.945 1.191 1.007 1.081 0.856 1.027513228 nan 0.931544866 nan 1.26031746 nan 0.791859389 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:0034645;GO:0043170;GO:1901360;GO:0032774;GO:0006355;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0060255;GO:0010468;GO:0018130;GO:1901576;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0044260;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0050794;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0051252;GO:0034641;GO:0010556;GO:0006351;GO:0019438;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;regulation of transcription, DNA-templated;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of macromolecule metabolic process;regulation of gene expression;heterocycle biosynthetic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular macromolecule metabolic process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;regulation of cellular process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of RNA metabolic process;cellular nitrogen compound metabolic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process; 4;3;5;4;4;5;4;3;5;4;4;6;6;5;6;2;3;5;2;7;4;5;5;4;5;4;2;4;7;4;3;5;1;4;2;6;5;3;4;5;3;5;5;4;5;6;5;3; GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005575;GO:0031981;GO:0005634;GO:0005654;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cellular_component;nuclear lumen;nucleus;nucleoplasm;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;3;2;1;5;5;5;4;3;2;2;3;3;4;4;3;2; GO:1901363;GO:0003674;GO:0001071;GO:0003677;GO:0043167;GO:0043169;GO:0046872;GO:0003676;GO:0003700;GO:0097159;GO:0005488; heterocyclic compound binding;molecular_function;nucleic acid binding transcription factor activity;DNA binding;ion binding;cation binding;metal ion binding;nucleic acid binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;binding; 3;1;2;5;3;4;5;4;3;3;2; K09228 IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs22050478 1409.0 R [R] General function prediction only; P48740 Mannan-binding lectin serine protease 1 OS=Homo sapiens OX=9606 GN=MASP1 PE=1 SV=3 - [MASP1_HUMAN] 0.971 0.957 1.173 0.958 1.082 0.973 1.014629049 0.848112096 0.885397412 0.249593554 1.225705329 0.028245883 0.899260628 0.398769914 GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0031347;GO:0044710;GO:0010605;GO:0032101;GO:0009611;GO:0048518;GO:0065007;GO:2000258;GO:0060255;GO:0050777;GO:2000257;GO:0050776;GO:0030162;GO:0002673;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0010629;GO:0009892;GO:0002921;GO:0002920;GO:0050789;GO:0044267;GO:0044260;GO:0002684;GO:0002682;GO:0002683;GO:0045916;GO:0006810;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0006954;GO:0006955;GO:0002526;GO:0006959;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0006898;GO:0002697;GO:1903318;GO:0006956;GO:1903317;GO:0002698;GO:0008152;GO:0050727;GO:0030449;GO:0044699;GO:0051248;GO:0051234;GO:0051246;GO:0001867;GO:0006508;GO:1903034;GO:0009987;GO:0048519;GO:0016485;GO:0032269;GO:0032268;GO:0050778;GO:0043170;GO:0045861;GO:0080134;GO:0031324;GO:0031323;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0010955;GO:0051179;GO:0044238;GO:0044237;GO:0002253;GO:0002252;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of defense response;single-organism metabolic process;negative regulation of macromolecule metabolic process;regulation of response to external stimulus;response to wounding;positive regulation of biological process;biological regulation;negative regulation of protein activation cascade;regulation of macromolecule metabolic process;negative regulation of immune response;regulation of protein activation cascade;regulation of immune response;regulation of proteolysis;regulation of acute inflammatory response;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;negative regulation of gene expression;negative regulation of metabolic process;negative regulation of humoral immune response;regulation of humoral immune response;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;positive regulation of immune system process;regulation of immune system process;negative regulation of immune system process;negative regulation of complement activation;transport;regulation of cellular process;defense response;response to stress;biological_process;inflammatory response;immune response;acute inflammatory response;humoral immune response;regulation of protein processing;endocytosis;protein maturation;response to stimulus;receptor-mediated endocytosis;regulation of immune effector process;negative regulation of protein maturation;complement activation;regulation of protein maturation;negative regulation of immune effector process;metabolic process;regulation of inflammatory response;regulation of complement activation;single-organism process;negative regulation of protein metabolic process;establishment of localization;regulation of protein metabolic process;complement activation, lectin pathway;proteolysis;regulation of response to wounding;cellular process;negative regulation of biological process;protein processing;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;positive regulation of immune response;macromolecule metabolic process;negative regulation of proteolysis;regulation of response to stress;negative regulation of cellular metabolic process;regulation of cellular metabolic process;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;negative regulation of protein processing;localization;primary metabolic process;cellular metabolic process;activation of immune response;immune effector process;negative regulation of cellular process; 4;3;3;3;3;5;3;4;4;4;2;2;4;4;4;4;4;6;6;5;3;4;2;5;3;5;5;2;5;4;3;3;3;5;4;3;4;3;1;5;3;6;4;7;6;5;2;7;4;6;4;6;4;2;5;5;2;5;3;5;5;5;5;2;2;6;5;5;4;4;6;4;4;4;3;3;5;5;4;7;2;3;3;3;3;3; GO:0044421;GO:0005615;GO:0005575;GO:0005576; extracellular region part;extracellular space;cellular_component;extracellular region; 2;3;1;2; GO:0004252;GO:0046983;GO:0046872;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0048306;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0005509;GO:0042802;GO:0042803;GO:0005515;GO:0004175;GO:0070011; serine-type endopeptidase activity;protein dimerization activity;metal ion binding;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;calcium-dependent protein binding;peptidase activity;serine-type peptidase activity;cation binding;ion binding;calcium ion binding;identical protein binding;protein homodimerization activity;protein binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;5;4;1;2;3;2;4;4;5;4;3;6;4;5;3;6;5; K03992 map04610;map05150; Complement and coagulation cascades;Staphylococcus aureus infection; IPR018097;IPR001254;IPR000859;IPR000436;IPR009003;IPR001314;IPR001881;IPR013032;IPR033116;IPR018114; EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;CUB domain;Sushi/SCR/CCP domain;Peptidase S1, PA clan;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular Hs21264357 1467.0 E [E] Amino acid transport and metabolism; Q5VIR6 Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=1 - [VPS53_HUMAN] 0.913 0.884 1.41 1.064 0.93 0.724 1.03280543 nan 1.144086022 nan 1.595022624 nan 0.778494624 nan GO:0008104;GO:0044699;GO:0071702;GO:0051641;GO:0016192;GO:0006810;GO:0045184;GO:0015031;GO:0044765;GO:0008150;GO:0007034;GO:0042147;GO:0051649;GO:0051234;GO:0051179;GO:1902578;GO:0016482;GO:0016197;GO:0033036;GO:0046907;GO:0032456;GO:1902582; protein localization;single-organism process;organic substance transport;cellular localization;vesicle-mediated transport;transport;establishment of protein localization;protein transport;single-organism transport;biological_process;vacuolar transport;retrograde transport, endosome to Golgi;establishment of localization in cell;establishment of localization;localization;single-organism localization;cytosolic transport;endosomal transport;macromolecule localization;intracellular transport;endocytic recycling;single-organism intracellular transport; 4;2;5;3;5;4;4;5;4;1;6;6;4;3;2;3;6;7;3;5;6;5; GO:0000938;GO:0055037;GO:1990745;GO:0043229;GO:0005774;GO:0043227;GO:0043226;GO:0010008;GO:0005737;GO:0044446;GO:0097708;GO:0031982;GO:0016023;GO:0031410;GO:0098805;GO:0016020;GO:0031988;GO:0044433;GO:0044431;GO:0044437;GO:0048471;GO:0005794;GO:0044440;GO:0098588;GO:0043234;GO:0032991;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005773;GO:0044444;GO:0031090;GO:0044424;GO:0005768;GO:0044422;GO:0012505; GARP complex;recycling endosome;EARP complex;intracellular organelle;vacuolar membrane;membrane-bounded organelle;organelle;endosome membrane;cytoplasm;intracellular organelle part;intracellular vesicle;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;whole membrane;membrane;membrane-bounded vesicle;cytoplasmic vesicle part;Golgi apparatus part;vacuolar part;perinuclear region of cytoplasm;Golgi apparatus;endosomal part;bounding membrane of organelle;protein complex;macromolecular complex;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;vacuole;cytoplasmic part;organelle membrane;intracellular part;endosome;organelle part;endomembrane system; 4;5;4;3;4;3;2;5;4;3;4;4;5;5;3;2;5;4;4;4;5;4;5;4;3;2;4;2;2;3;1;5;4;3;3;4;2;3; K20299 IPR007234; Vps53-like, N-terminal; cytosol Hs21361728 1380.0 U [U] Intracellular trafficking, secretion, and vesicular transport; O14983 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Homo sapiens OX=9606 GN=ATP2A1 PE=1 SV=1 - [AT2A1_HUMAN] 0.846 0.982 1.41 0.984 0.805 1.311 0.861507128 nan 1.222360248 nan 1.435845214 nan 1.628571429 nan GO:0007599;GO:1903779;GO:0007596;GO:0003010;GO:0003012;GO:0003013;GO:0051659;GO:0003015;GO:0098771;GO:0051657;GO:0051651;GO:0051561;GO:0051560;GO:0051716;GO:0009611;GO:0048518;GO:0048519;GO:0045988;GO:0098662;GO:0019725;GO:0006936;GO:0006937;GO:0098660;GO:0072511;GO:0045989;GO:0003009;GO:0003008;GO:0044700;GO:0044707;GO:0090076;GO:0090075;GO:0060047;GO:0070509;GO:0033554;GO:0014721;GO:0055074;GO:0014819;GO:0070588;GO:0035556;GO:0048878;GO:0050789;GO:0016043;GO:0065007;GO:0065008;GO:0006810;GO:0008015;GO:0006812;GO:0006811;GO:0008016;GO:0006816;GO:0042060;GO:0050794;GO:0012501;GO:0006950;GO:0050817;GO:1903522;GO:0051239;GO:0051235;GO:0051234;GO:0072503;GO:0070059;GO:0050896;GO:0008150;GO:0034976;GO:0035637;GO:0050801;GO:0006941;GO:0006942;GO:0023052;GO:0007165;GO:0014724;GO:0023051;GO:0007005;GO:0044699;GO:0072507;GO:0050881;GO:0044057;GO:0051240;GO:0051241;GO:1902578;GO:0031446;GO:0032501;GO:0050878;GO:0050879;GO:0006875;GO:0006874;GO:0009987;GO:0006873;GO:0032471;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0055085;GO:0008637;GO:0070838;GO:0032470;GO:0097190;GO:0097193;GO:0042592;GO:0071840;GO:0008219;GO:0032469;GO:0045933;GO:0045932;GO:0061337;GO:0006915;GO:0034220;GO:0044765;GO:0044763;GO:0090257;GO:0055065;GO:0051646;GO:0007154;GO:0051179;GO:0051640;GO:0051641;GO:0006996;GO:0098655;GO:0031443;GO:0031448;GO:1902580; hemostasis;regulation of cardiac conduction;blood coagulation;voluntary skeletal muscle contraction;muscle system process;circulatory system process;maintenance of mitochondrion location;heart process;inorganic ion homeostasis;maintenance of organelle location;maintenance of location in cell;positive regulation of mitochondrial calcium ion concentration;mitochondrial calcium ion homeostasis;cellular response to stimulus;response to wounding;positive regulation of biological process;negative regulation of biological process;negative regulation of striated muscle contraction;inorganic cation transmembrane transport;cellular homeostasis;muscle contraction;regulation of muscle contraction;inorganic ion transmembrane transport;divalent inorganic cation transport;positive regulation of striated muscle contraction;skeletal muscle contraction;system process;single organism signaling;single-multicellular organism process;relaxation of skeletal muscle;relaxation of muscle;heart contraction;calcium ion import;cellular response to stress;twitch skeletal muscle contraction;calcium ion homeostasis;regulation of skeletal muscle contraction;calcium ion transmembrane transport;intracellular signal transduction;chemical homeostasis;regulation of biological process;cellular component organization;biological regulation;regulation of biological quality;transport;blood circulation;cation transport;ion transport;regulation of heart contraction;calcium ion transport;wound healing;regulation of cellular process;programmed cell death;response to stress;coagulation;regulation of blood circulation;regulation of multicellular organismal process;maintenance of location;establishment of localization;cellular divalent inorganic cation homeostasis;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;response to stimulus;biological_process;response to endoplasmic reticulum stress;multicellular organismal signaling;ion homeostasis;striated muscle contraction;regulation of striated muscle contraction;signaling;signal transduction;regulation of twitch skeletal muscle contraction;regulation of signaling;mitochondrion organization;single-organism process;divalent inorganic cation homeostasis;musculoskeletal movement;regulation of system process;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;single-organism localization;regulation of fast-twitch skeletal muscle fiber contraction;multicellular organismal process;regulation of body fluid levels;multicellular organismal movement;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular process;cellular ion homeostasis;negative regulation of endoplasmic reticulum calcium ion concentration;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;apoptotic mitochondrial changes;divalent metal ion transport;positive regulation of endoplasmic reticulum calcium ion concentration;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;homeostatic process;cellular component organization or biogenesis;cell death;endoplasmic reticulum calcium ion homeostasis;positive regulation of muscle contraction;negative regulation of muscle contraction;cardiac conduction;apoptotic process;ion transmembrane transport;single-organism transport;single-organism cellular process;regulation of muscle system process;metal ion homeostasis;mitochondrion localization;cell communication;localization;organelle localization;cellular localization;organelle organization;cation transmembrane transport;fast-twitch skeletal muscle fiber contraction;positive regulation of fast-twitch skeletal muscle fiber contraction;single-organism cellular localization; 5;4;5;7;4;4;5;5;7;5;4;11;10;3;4;2;2;5;7;4;5;6;6;7;5;6;3;3;3;6;5;6;10;4;8;9;7;8;5;5;2;3;2;3;4;5;6;5;6;9;5;3;5;3;4;5;3;3;3;8;6;2;1;5;4;6;6;7;2;4;8;3;5;2;8;5;4;3;3;3;9;2;4;4;8;9;2;6;11;7;7;7;5;4;6;8;11;5;6;4;2;4;10;4;4;5;6;5;4;3;5;8;5;4;2;4;3;4;6;9;6;4; GO:0005783;GO:0005789;GO:0016021;GO:0016020;GO:1902495;GO:0098588;GO:0043234;GO:0043231;GO:0030017;GO:0044424;GO:0044425;GO:0044422;GO:0043232;GO:0034704;GO:0043228;GO:0034702;GO:0034703;GO:0043227;GO:0031673;GO:0031672;GO:0031674;GO:0033017;GO:0044432;GO:0031224;GO:0048471;GO:0031095;GO:0031094;GO:1990351;GO:0012505;GO:0044446;GO:0044444;GO:0044449;GO:0005886;GO:0030016;GO:0042175;GO:0031226;GO:0005737;GO:0031090;GO:0005739;GO:0044459;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0016528;GO:0016529;GO:0071944;GO:0005793;GO:0043226;GO:0005887;GO:0032991;GO:0005575;GO:0098796;GO:0043292; endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;transmembrane transporter complex;bounding membrane of organelle;protein complex;intracellular membrane-bounded organelle;sarcomere;intracellular part;membrane part;organelle part;intracellular non-membrane-bounded organelle;calcium channel complex;non-membrane-bounded organelle;ion channel complex;cation channel complex;membrane-bounded organelle;H zone;A band;I band;sarcoplasmic reticulum membrane;endoplasmic reticulum part;intrinsic component of membrane;perinuclear region of cytoplasm;platelet dense tubular network membrane;platelet dense tubular network;transporter complex;endomembrane system;intracellular organelle part;cytoplasmic part;contractile fiber part;plasma membrane;myofibril;nuclear outer membrane-endoplasmic reticulum membrane network;intrinsic component of plasma membrane;cytoplasm;organelle membrane;mitochondrion;plasma membrane part;cell part;intracellular organelle;cell;intracellular;sarcoplasm;sarcoplasmic reticulum;cell periphery;endoplasmic reticulum-Golgi intermediate compartment;organelle;integral component of plasma membrane;macromolecular complex;cellular_component;membrane protein complex;contractile fiber; 4;3;4;2;4;4;3;4;4;3;2;2;4;7;3;5;6;3;4;4;4;4;4;3;5;4;5;4;3;3;4;3;3;6;3;4;4;3;5;3;2;3;2;3;5;5;3;5;2;4;2;1;3;5; GO:0043169;GO:1901363;GO:0015085;GO:0015399;GO:0000166;GO:0019829;GO:0046873;GO:0046872;GO:0008324;GO:0016818;GO:0097367;GO:0016817;GO:0015405;GO:0016787;GO:0016887;GO:1901265;GO:0042625;GO:0042626;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0005388;GO:0022891;GO:0022890;GO:0022892;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0046983;GO:0032550;GO:0032553;GO:0035639;GO:0015662;GO:0072509;GO:0016820;GO:0043167;GO:0042802;GO:0005509;GO:0030554;GO:0005515;GO:0003674;GO:0042803;GO:0043492;GO:0005488;GO:0001883;GO:0001882;GO:0015075;GO:0005215;GO:0022804;GO:0017111;GO:0036094;GO:0003824;GO:0043168;GO:0022857;GO:0022853; cation binding;heterocyclic compound binding;calcium ion transmembrane transporter activity;primary active transmembrane transporter activity;nucleotide binding;cation-transporting ATPase activity;metal ion transmembrane transporter activity;metal ion binding;cation transmembrane transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;P-P-bond-hydrolysis-driven transmembrane transporter activity;hydrolase activity;ATPase activity;nucleoside phosphate binding;ATPase coupled ion transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;calcium-transporting ATPase activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;protein dimerization activity;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;divalent inorganic cation transmembrane transporter activity;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ion binding;identical protein binding;calcium ion binding;adenyl nucleotide binding;protein binding;molecular_function;protein homodimerization activity;ATPase activity, coupled to movement of substances;binding;purine nucleoside binding;nucleoside binding;ion transmembrane transporter activity;transporter activity;active transmembrane transporter activity;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;anion binding;transmembrane transporter activity;active ion transmembrane transporter activity; 4;3;9;5;4;7;8;5;6;5;3;4;6;3;8;4;6;6;9;5;5;6;8;4;7;3;3;6;6;5;4;6;4;5;7;8;5;3;4;6;6;3;1;5;10;2;5;4;5;2;4;7;3;2;4;3;5; K05853 map04020;map04022;map04972;map05010; Calcium signaling pathway;cGMP-PKG signaling pathway;Pancreatic secretion;Alzheimer's disease; IPR005782;IPR018303;IPR023298;IPR023299;IPR004014;IPR006068;IPR030332;IPR023214;IPR008250;IPR001757; P-type ATPase, subfamily IIA, SERCA-type;P-type ATPase, phosphorylation site;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;Cation-transporting P-type ATPase, N-terminal;Cation-transporting P-type ATPase, C-terminal;Sarcoplasmic/endoplasmic reticulum calcium ATPase 1;HAD-like domain;P-type ATPase, A domain;P-type ATPase; plasma membrane Hs10835220 2040.0 P [P] Inorganic ion transport and metabolism; Q5VUG0 Scm-like with four MBT domains protein 2 OS=Homo sapiens OX=9606 GN=SFMBT2 PE=1 SV=1 - [SMBT2_HUMAN] 1.098 1.024 1.028 0.983 0.997 1.156 1.072265625 nan 0.985957874 nan 1.00390625 nan 1.159478435 nan GO:0009892;GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:0034645;GO:0043170;GO:1901360;GO:0032774;GO:0010605;GO:0006355;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0048519;GO:0010468;GO:0018130;GO:1901576;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0044260;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:2001141;GO:0034654;GO:0050794;GO:0046483;GO:0016070;GO:0044238;GO:0010629;GO:0044271;GO:0060255;GO:0051252;GO:0034641;GO:0010556;GO:0006351;GO:0019438;GO:0044237;GO:0051171; negative regulation of metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;negative regulation of macromolecule metabolic process;regulation of transcription, DNA-templated;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;negative regulation of biological process;regulation of gene expression;heterocycle biosynthetic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular macromolecule metabolic process;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;regulation of cellular process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;negative regulation of gene expression;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular nitrogen compound metabolic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process;regulation of nitrogen compound metabolic process; 3;4;3;5;4;4;5;4;3;5;4;4;6;4;6;5;6;2;3;5;2;7;2;5;5;4;5;4;2;4;7;4;3;5;1;2;6;5;3;4;5;3;5;5;4;5;4;5;6;5;3;4; GO:0016234;GO:0016235;GO:0043229;GO:0043227;GO:0043226;GO:0005575;GO:0031981;GO:0005634;GO:0005654;GO:0031974;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; inclusion body;aggresome;intracellular organelle;membrane-bounded organelle;organelle;cellular_component;nuclear lumen;nucleus;nucleoplasm;membrane-enclosed lumen;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 4;5;3;3;2;1;5;5;5;2;4;3;2;2;3;3;4;4;3;2; GO:0042393;GO:0003674;GO:0005488;GO:0005515; histone binding;molecular_function;binding;protein binding; 4;1;2;3; IPR021987;IPR013761;IPR001660;IPR004092; SLED domain;Sterile alpha motif/pointed domain;Sterile alpha motif domain;Mbt repeat; cytosol Hs20472060 1862.0 K [K] Transcription; Q9BZ19 Ankyrin repeat domain-containing protein 60 OS=Homo sapiens OX=9606 GN=ANKRD60 PE=4 SV=3 - [ANR60_HUMAN] 1.051 1.511 0.643 0.964 1.212 0.627 0.69556585 nan 0.795379538 nan 0.425545996 nan 0.517326733 nan IPR000626;IPR002110;IPR020683;IPR029071; Ubiquitin domain;Ankyrin repeat;Ankyrin repeat-containing domain;Ubiquitin-related domain; mitochondria Hs18129634 689.0 M [M] Cell wall/membrane/envelope biogenesis; Q86T13 C-type lectin domain family 14 member A OS=Homo sapiens OX=9606 GN=CLEC14A PE=1 SV=1 - [CLC14_HUMAN] 1.165 1.005 0.758 0.987 1.24 1.254 1.15920398 nan 0.795967742 nan 0.754228856 nan 1.011290323 nan GO:0043230;GO:0070062;GO:0016021;GO:0016020;GO:0044421;GO:0005575;GO:0005576;GO:0044425;GO:1903561;GO:0043227;GO:0043226;GO:0031224;GO:0031982; extracellular organelle;extracellular exosome;integral component of membrane;membrane;extracellular region part;cellular_component;extracellular region;membrane part;extracellular vesicle;membrane-bounded organelle;organelle;intrinsic component of membrane;vesicle; 3;4;4;2;2;1;2;2;3;3;2;3;4; GO:0030246;GO:0003674;GO:0005488; carbohydrate binding;molecular_function;binding; 3;1;2; K17528 IPR016186;IPR001304;IPR016187; C-type lectin-like/link domain;C-type lectin-like;C-type lectin fold; extracellular A0A075B6Q5 Immunoglobulin heavy variable 3-64 OS=Homo sapiens OX=9606 GN=IGHV3-64 PE=3 SV=1 - [HV364_HUMAN] 1.176 1 0.918 1 1.03 1.262 1.176 0.167116059 0.970873786 0.421745628 0.918 0.448375669 1.225242718 0.250931799 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q8IXM7 Outer dense fiber protein 3-like protein 1 OS=Homo sapiens OX=9606 GN=ODF3L1 PE=2 SV=1 - [OD3L1_HUMAN] 1.468 0.795 0.718 1.172 1.072 1.048 1.846540881 nan 1.093283582 nan 0.903144654 nan 0.97761194 nan IPR010736; Sperm-tail PG-rich repeat; cytosol P01019 Angiotensinogen OS=Homo sapiens OX=9606 GN=AGT PE=1 SV=1 - [ANGT_HUMAN] 0.954 1.043 1.072 0.969 1.068 0.986 0.914669223 0.000509976 0.907303371 0.000807591 1.02780441 0.002323183 0.923220974 0.017698376 GO:0051169;GO:0014743;GO:0051046;GO:0051047;GO:0051049;GO:0001667;GO:0019226;GO:0044281;GO:0098771;GO:0051716;GO:0016486;GO:0000003;GO:0045428;GO:0048588;GO:0018212;GO:0003300;GO:0015844;GO:0003298;GO:2001238;GO:0045859;GO:0032846;GO:0044060;GO:0046483;GO:0042325;GO:0042327;GO:0010631;GO:0009605;GO:0019538;GO:0042692;GO:0032410;GO:0009893;GO:0032412;GO:0032413;GO:2000831;GO:1901342;GO:1901343;GO:0035411;GO:0010863;GO:0050789;GO:0001816;GO:0042554;GO:0051347;GO:0051346;GO:0051345;GO:0001817;GO:0006886;GO:0006883;GO:1903409;GO:0097006;GO:1901360;GO:1903598;GO:0018130;GO:2000379;GO:0006629;GO:0009306;GO:0090190;GO:1903524;GO:1903522;GO:0016070;GO:0003331;GO:0072028;GO:0001974;GO:0010557;GO:0001976;GO:0048869;GO:2000650;GO:0044085;GO:0048146;GO:0048145;GO:0048144;GO:0051128;GO:0038127;GO:0045926;GO:0050432;GO:0050433;GO:0003051;GO:0045742;GO:1904407;GO:0015672;GO:0008284;GO:0055001;GO:0055002;GO:0035239;GO:0055006;GO:0008283;GO:0006875;GO:0050877;GO:0006873;GO:0051952;GO:0001558;GO:0001655;GO:0045216;GO:0001657;GO:0001658;GO:0044255;GO:0042058;GO:0030258;GO:0034329;GO:0071825;GO:0072511;GO:0033860;GO:0016525;GO:1902305;GO:2000181;GO:0060341;GO:0097190;GO:0097191;GO:0018108;GO:0042592;GO:0008217;GO:0033864;GO:0008219;GO:0046209;GO:0007275;GO:0034369;GO:0043502;GO:2000112;GO:0014896;GO:0051937;GO:0043065;GO:0043067;GO:0097696;GO:0043062;GO:0043068;GO:0006468;GO:0019216;GO:0019219;GO:0019218;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0090257;GO:0010951;GO:0006518;GO:0040011;GO:0051272;GO:0051270;GO:0010595;GO:0010594;GO:0040017;GO:0002018;GO:0014061;GO:0002016;GO:0048856;GO:0009914;GO:1903596;GO:0006796;GO:2000021;GO:2000026;GO:2000027;GO:0006793;GO:0014850;GO:0048523;GO:0048522;GO:0008104;GO:1903779;GO:1901890;GO:0032147;GO:0007610;GO:0031349;GO:0003012;GO:0003013;GO:0003014;GO:0003015;GO:0007166;GO:0007167;GO:0003018;GO:0007169;GO:0010556;GO:0031347;GO:0042445;GO:0044710;GO:0050729;GO:0030308;GO:0050727;GO:0044093;GO:0044092;GO:0035932;GO:0060993;GO:0035930;GO:0033036;GO:0010634;GO:0006936;GO:0034367;GO:0034368;GO:0006939;GO:0061049;GO:2001141;GO:0010033;GO:0051704;GO:1900274;GO:0010632;GO:0023057;GO:0090077;GO:0003081;GO:0015850;GO:0003301;GO:0030335;GO:0001763;GO:0006801;GO:0042310;GO:0042311;GO:0042312;GO:0006809;GO:0044267;GO:0010646;GO:0044260;GO:0001568;GO:0048589;GO:0061097;GO:0061098;GO:0007186;GO:0007187;GO:0009887;GO:0006915;GO:0033554;GO:0050793;GO:0035929;GO:0050790;GO:0009889;GO:0009888;GO:0050794;GO:0051239;GO:0051234;GO:0051336;GO:0010959;GO:0032368;GO:0022898;GO:0050896;GO:0051338;GO:0014897;GO:2000145;GO:2000147;GO:0051969;GO:0060986;GO:0051240;GO:0060193;GO:0060191;GO:0032103;GO:0032101;GO:0001944;GO:0051173;GO:0070278;GO:0090288;GO:0090322;GO:0022607;GO:0007043;GO:1903530;GO:0070887;GO:1903532;GO:0009892;GO:0044699;GO:0090287;GO:0044057;GO:0010562;GO:0022603;GO:0051246;GO:0051247;GO:0002027;GO:0032409;GO:0060688;GO:0031399;GO:1903034;GO:0070471;GO:1903036;GO:1902593;GO:0072594;GO:0072593;GO:0043271;GO:0040012;GO:0014068;GO:0014065;GO:0014066;GO:0009891;GO:0090132;GO:0003044;GO:0070838;GO:0002019;GO:2000846;GO:0010766;GO:1904062;GO:1904063;GO:1902680;GO:0072080;GO:0002028;GO:0033365;GO:0048731;GO:0072088;GO:0070371;GO:0051387;GO:0051386;GO:0061326;GO:0043933;GO:0034330;GO:0014706;GO:0051146;GO:0001525;GO:0035556;GO:0048169;GO:0035725;GO:0061217;GO:0061213;GO:0043542;GO:0017038;GO:0045935;GO:0045937;GO:0061138;GO:0052548;GO:0035051;GO:0051341;GO:0010817;GO:0022414;GO:0055067;GO:0055065;GO:0007267;GO:0042221;GO:0035295;GO:0007263;GO:0009628;GO:0010611;GO:0051924;GO:0044237;GO:0060537;GO:0042976;GO:0042977;GO:2001235;GO:2001236;GO:0019220;GO:0019222;GO:2001233;GO:0032928;GO:0048585;GO:0048584;GO:0048583;GO:0019229;GO:0032844;GO:0072359;GO:0072358;GO:0060081;GO:1901362;GO:0071840;GO:0009968;GO:0009966;GO:0009967;GO:0001823;GO:0001822;GO:0046879;GO:0048513;GO:0048514;GO:0048518;GO:0048519;GO:0090130;GO:0042127;GO:1902306;GO:0038179;GO:1901888;GO:0006606;GO:0032269;GO:0006605;GO:0045184;GO:0051090;GO:0007173;GO:0042756;GO:0003008;GO:0044700;GO:0044703;GO:0016477;GO:1901564;GO:0044707;GO:0044706;GO:0050731;GO:0050730;GO:0000165;GO:0010533;GO:0033002;GO:0098916;GO:0010536;GO:0010535;GO:0010534;GO:0007165;GO:0042391;GO:0014742;GO:0034374;GO:0033674;GO:0071260;GO:0048167;GO:0051674;GO:0034765;GO:0042981;GO:0048168;GO:0097659;GO:0048243;GO:0003072;GO:0003073;GO:0003071;GO:0043549;GO:0090066;GO:0023014;GO:0071214;GO:0007588;GO:0048646;GO:0035150;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:2000377;GO:0006952;GO:0012501;GO:0006950;GO:0006954;GO:0034654;GO:1902533;GO:1902531;GO:0048015;GO:0048017;GO:0046903;GO:0044271;GO:0046907;GO:0080134;GO:0031401;GO:0043412;GO:0007199;GO:0006355;GO:0006351;GO:0085029;GO:0099536;GO:0099537;GO:0055017;GO:0014874;GO:0014873;GO:0030154;GO:0070848;GO:0048011;GO:0045429;GO:0060047;GO:0009612;GO:0015837;GO:0061061;GO:0055013;GO:1901201;GO:0006139;GO:0050880;GO:0050886;GO:0007259;GO:0032270;GO:0060562;GO:0032502;GO:0032501;GO:1903053;GO:0009987;GO:0006725;GO:1903506;GO:1903055;GO:0072009;GO:0072163;GO:0072164;GO:0016485;GO:0044744;GO:0072001;GO:0032879;GO:0048771;GO:0072006;GO:0035931;GO:0071363;GO:0051604;GO:0044062;GO:0051252;GO:0051254;GO:0002035;GO:0002034;GO:0003330;GO:0001819;GO:0034504;GO:0014829;GO:0007507;GO:0072171;GO:2000858;GO:2000855;GO:0048754;GO:2001057;GO:0051241;GO:0043269;GO:0010628;GO:0051051;GO:0010468;GO:0051050;GO:0045765;GO:0071705;GO:0071704;GO:0071310;GO:0034433;GO:0034434;GO:0034435;GO:0048729;GO:0071702;GO:0035813;GO:0035812;GO:0035815;GO:0061333;GO:0030334;GO:0046427;GO:0061337;GO:0046425;GO:0034613;GO:0006913;GO:0023061;GO:0051174;GO:0034220;GO:0009058;GO:0009059;GO:0051170;GO:0051171;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0043500;GO:1902582;GO:1902580;GO:0002002;GO:0002003;GO:0080090;GO:0015874;GO:0045909;GO:0098801;GO:0035265;GO:0055078;GO:0034766;GO:0046883;GO:0034762;GO:0034763;GO:0010605;GO:0010604;GO:0070727;GO:0009611;GO:0018193;GO:0010466;GO:0045834;GO:0019725;GO:0032930;GO:0060255;GO:0014820;GO:0014823;GO:0014824;GO:0030162;GO:0010872;GO:0010873;GO:0001991;GO:0001990;GO:0010876;GO:0048870;GO:0007200;GO:0007202;GO:0048878;GO:0060419;GO:0030198;GO:0019438;GO:0007631;GO:0090189;GO:0090184;GO:0090183;GO:0060177;GO:0032940;GO:0060675;GO:1901186;GO:1901184;GO:0051353;GO:1901576;GO:0016049;GO:0052547;GO:0016043;GO:0065007;GO:0098662;GO:2000649;GO:0065009;GO:0065008;GO:0051130;GO:0016264;GO:0008015;GO:0008016;GO:0048468;GO:0036211;GO:0008150;GO:1902630;GO:0008152;GO:1902632;GO:0010613;GO:0031644;GO:0098660;GO:0048659;GO:0035637;GO:0006869;GO:0050803;GO:0016310;GO:0050801;GO:0007268;GO:0050804;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010647;GO:0009653;GO:0043086;GO:0043085;GO:0006928;GO:0048738;GO:0044238;GO:0060429;GO:0045597;GO:0030004;GO:0045595;GO:0030001;GO:0045893;GO:0030003;GO:0006508;GO:0055080;GO:0055082;GO:0055085;GO:0008202;GO:0051093;GO:0051092;GO:0051091;GO:0032268;GO:0007568;GO:0043603;GO:0051094;GO:0007565;GO:0043170;GO:0045940;GO:0006807;GO:1904892;GO:0045861;GO:0045860;GO:1904894;GO:1903508;GO:0032774;GO:0019932;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0071496;GO:0072078;GO:0010942;GO:0010941;GO:0072073;GO:0050663;GO:0002009;GO:0071827;GO:0040007;GO:0044087;GO:0040008;GO:0055007;GO:0006814;GO:0010467;GO:1903428;GO:0010744;GO:1903426;GO:0010742;GO:0010743;GO:0034103;GO:0034104;GO:0051403;GO:0007154;GO:0051248;GO:0098655;GO:0031098;GO:0045777;GO:0010518;GO:0015031;GO:0001932;GO:0001934;GO:0010517;GO:0044089; nuclear transport;regulation of muscle hypertrophy;regulation of secretion;positive regulation of secretion;regulation of transport;ameboidal-type cell migration;transmission of nerve impulse;small molecule metabolic process;inorganic ion homeostasis;cellular response to stimulus;peptide hormone processing;reproduction;regulation of nitric oxide biosynthetic process;developmental cell growth;peptidyl-tyrosine modification;cardiac muscle hypertrophy;monoamine transport;physiological muscle hypertrophy;positive regulation of extrinsic apoptotic signaling pathway;regulation of protein kinase activity;positive regulation of homeostatic process;regulation of endocrine process;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;epithelial cell migration;response to external stimulus;protein metabolic process;muscle cell differentiation;negative regulation of transporter activity;positive regulation of metabolic process;regulation of ion transmembrane transporter activity;negative regulation of ion transmembrane transporter activity;regulation of steroid hormone secretion;regulation of vasculature development;negative regulation of vasculature development;catenin import into nucleus;positive regulation of phospholipase C activity;regulation of biological process;cytokine production;superoxide anion generation;positive regulation of transferase activity;negative regulation of hydrolase activity;positive regulation of hydrolase activity;regulation of cytokine production;intracellular protein transport;cellular sodium ion homeostasis;reactive oxygen species biosynthetic process;regulation of plasma lipoprotein particle levels;organic cyclic compound metabolic process;positive regulation of gap junction assembly;heterocycle biosynthetic process;positive regulation of reactive oxygen species metabolic process;lipid metabolic process;protein secretion;positive regulation of branching involved in ureteric bud morphogenesis;positive regulation of blood circulation;regulation of blood circulation;RNA metabolic process;positive regulation of extracellular matrix constituent secretion;nephron morphogenesis;blood vessel remodeling;positive regulation of macromolecule biosynthetic process;neurological system process involved in regulation of systemic arterial blood pressure;cellular developmental process;negative regulation of sodium ion transmembrane transporter activity;cellular component biogenesis;positive regulation of fibroblast proliferation;regulation of fibroblast proliferation;fibroblast proliferation;regulation of cellular component organization;ERBB signaling pathway;negative regulation of growth;catecholamine secretion;regulation of catecholamine secretion;angiotensin-mediated drinking behavior;positive regulation of epidermal growth factor receptor signaling pathway;positive regulation of nitric oxide metabolic process;monovalent inorganic cation transport;positive regulation of cell proliferation;muscle cell development;striated muscle cell development;tube morphogenesis;cardiac cell development;cell proliferation;cellular metal ion homeostasis;neurological system process;cellular ion homeostasis;regulation of amine transport;regulation of cell growth;urogenital system development;cell-cell junction organization;ureteric bud development;branching involved in ureteric bud morphogenesis;cellular lipid metabolic process;regulation of epidermal growth factor receptor signaling pathway;lipid modification;cell junction assembly;protein-lipid complex subunit organization;divalent inorganic cation transport;regulation of NAD(P)H oxidase activity;negative regulation of angiogenesis;regulation of sodium ion transmembrane transport;negative regulation of blood vessel morphogenesis;regulation of cellular localization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;peptidyl-tyrosine phosphorylation;homeostatic process;regulation of blood pressure;positive regulation of NAD(P)H oxidase activity;cell death;nitric oxide metabolic process;multicellular organism development;plasma lipoprotein particle remodeling;regulation of muscle adaptation;regulation of cellular macromolecule biosynthetic process;muscle hypertrophy;catecholamine transport;positive regulation of apoptotic process;regulation of programmed cell death;STAT cascade;extracellular structure organization;positive regulation of programmed cell death;protein phosphorylation;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of steroid metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;regulation of muscle system process;negative regulation of endopeptidase activity;peptide metabolic process;locomotion;positive regulation of cellular component movement;regulation of cellular component movement;positive regulation of endothelial cell migration;regulation of endothelial cell migration;positive regulation of locomotion;renin-angiotensin regulation of aldosterone production;regulation of norepinephrine secretion;regulation of blood volume by renin-angiotensin;anatomical structure development;hormone transport;regulation of gap junction assembly;phosphate-containing compound metabolic process;regulation of ion homeostasis;regulation of multicellular organismal development;regulation of organ morphogenesis;phosphorus metabolic process;response to muscle activity;negative regulation of cellular process;positive regulation of cellular process;protein localization;regulation of cardiac conduction;positive regulation of cell junction assembly;activation of protein kinase activity;behavior;positive regulation of defense response;muscle system process;circulatory system process;renal system process;heart process;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;vascular process in circulatory system;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of macromolecule biosynthetic process;regulation of defense response;hormone metabolic process;single-organism metabolic process;positive regulation of inflammatory response;negative regulation of cell growth;regulation of inflammatory response;positive regulation of molecular function;negative regulation of molecular function;aldosterone secretion;kidney morphogenesis;corticosteroid hormone secretion;macromolecule localization;positive regulation of epithelial cell migration;muscle contraction;macromolecular complex remodeling;protein-lipid complex remodeling;smooth muscle contraction;cell growth involved in cardiac muscle cell development;regulation of RNA biosynthetic process;response to organic substance;multi-organism process;regulation of phospholipase C activity;regulation of epithelial cell migration;negative regulation of signaling;foam cell differentiation;regulation of systemic arterial blood pressure by renin-angiotensin;organic hydroxy compound transport;physiological cardiac muscle hypertrophy;positive regulation of cell migration;morphogenesis of a branching structure;superoxide metabolic process;vasoconstriction;vasodilation;regulation of vasodilation;nitric oxide biosynthetic process;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;blood vessel development;developmental growth;regulation of protein tyrosine kinase activity;positive regulation of protein tyrosine kinase activity;G-protein coupled receptor signaling pathway;G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;organ morphogenesis;apoptotic process;cellular response to stress;regulation of developmental process;steroid hormone secretion;regulation of catalytic activity;regulation of biosynthetic process;tissue development;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;regulation of metal ion transport;regulation of lipid transport;regulation of transmembrane transporter activity;response to stimulus;regulation of transferase activity;striated muscle hypertrophy;regulation of cell motility;positive regulation of cell motility;regulation of transmission of nerve impulse;endocrine hormone secretion;positive regulation of multicellular organismal process;positive regulation of lipase activity;regulation of lipase activity;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;positive regulation of nitrogen compound metabolic process;extracellular matrix constituent secretion;negative regulation of cellular response to growth factor stimulus;regulation of superoxide metabolic process;cellular component assembly;cell-cell junction assembly;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;negative regulation of metabolic process;single-organism process;regulation of cellular response to growth factor stimulus;regulation of system process;positive regulation of phosphorus metabolic process;regulation of anatomical structure morphogenesis;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of heart rate;regulation of transporter activity;regulation of morphogenesis of a branching structure;regulation of protein modification process;regulation of response to wounding;uterine smooth muscle contraction;positive regulation of response to wounding;single-organism nuclear import;establishment of protein localization to organelle;reactive oxygen species metabolic process;negative regulation of ion transport;regulation of locomotion;positive regulation of phosphatidylinositol 3-kinase signaling;phosphatidylinositol 3-kinase signaling;regulation of phosphatidylinositol 3-kinase signaling;positive regulation of biosynthetic process;epithelium migration;regulation of systemic arterial blood pressure mediated by a chemical signal;divalent metal ion transport;regulation of renal output by angiotensin;regulation of corticosteroid hormone secretion;negative regulation of sodium ion transport;regulation of cation transmembrane transport;negative regulation of cation transmembrane transport;positive regulation of RNA biosynthetic process;nephron tubule development;regulation of sodium ion transport;protein localization to organelle;system development;nephron epithelium morphogenesis;ERK1 and ERK2 cascade;negative regulation of neurotrophin TRK receptor signaling pathway;regulation of neurotrophin TRK receptor signaling pathway;renal tubule development;macromolecular complex subunit organization;cell junction organization;striated muscle tissue development;striated muscle cell differentiation;angiogenesis;intracellular signal transduction;regulation of long-term neuronal synaptic plasticity;sodium ion transmembrane transport;regulation of mesonephros development;positive regulation of mesonephros development;endothelial cell migration;protein import;positive regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;morphogenesis of a branching epithelium;regulation of endopeptidase activity;cardiocyte differentiation;regulation of oxidoreductase activity;regulation of hormone levels;reproductive process;monovalent inorganic cation homeostasis;metal ion homeostasis;cell-cell signaling;response to chemical;tube development;nitric oxide mediated signal transduction;response to abiotic stimulus;regulation of cardiac muscle hypertrophy;regulation of calcium ion transport;cellular metabolic process;muscle tissue development;activation of Janus kinase activity;activation of JAK2 kinase activity;positive regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;regulation of superoxide anion generation;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of vasoconstriction;regulation of homeostatic process;circulatory system development;cardiovascular system development;membrane hyperpolarization;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;mesonephros development;kidney development;hormone secretion;animal organ development;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;tissue migration;regulation of cell proliferation;negative regulation of sodium ion transmembrane transport;neurotrophin signaling pathway;regulation of cell junction assembly;protein import into nucleus;negative regulation of cellular protein metabolic process;protein targeting;establishment of protein localization;regulation of sequence-specific DNA binding transcription factor activity;epidermal growth factor receptor signaling pathway;drinking behavior;system process;single organism signaling;multi-organism reproductive process;cell migration;organonitrogen compound metabolic process;single-multicellular organism process;multi-multicellular organism process;positive regulation of peptidyl-tyrosine phosphorylation;regulation of peptidyl-tyrosine phosphorylation;MAPK cascade;regulation of activation of Janus kinase activity;muscle cell proliferation;anterograde trans-synaptic signaling;positive regulation of activation of Janus kinase activity;positive regulation of activation of JAK2 kinase activity;regulation of activation of JAK2 kinase activity;signal transduction;regulation of membrane potential;positive regulation of muscle hypertrophy;low-density lipoprotein particle remodeling;positive regulation of kinase activity;cellular response to mechanical stimulus;regulation of synaptic plasticity;localization of cell;regulation of ion transmembrane transport;regulation of apoptotic process;regulation of neuronal synaptic plasticity;nucleic acid-templated transcription;norepinephrine secretion;renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure;regulation of systemic arterial blood pressure;renal system process involved in regulation of systemic arterial blood pressure;regulation of kinase activity;regulation of anatomical structure size;signal transduction by protein phosphorylation;cellular response to abiotic stimulus;excretion;anatomical structure formation involved in morphogenesis;regulation of tube size;cation transport;ion transport;transport;calcium ion transport;regulation of reactive oxygen species metabolic process;defense response;programmed cell death;response to stress;inflammatory response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;phosphatidylinositol-mediated signaling;inositol lipid-mediated signaling;secretion;cellular nitrogen compound biosynthetic process;intracellular transport;regulation of response to stress;positive regulation of protein modification process;macromolecule modification;G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;regulation of transcription, DNA-templated;transcription, DNA-templated;extracellular matrix assembly;synaptic signaling;trans-synaptic signaling;cardiac muscle tissue growth;response to stimulus involved in regulation of muscle adaptation;response to muscle activity involved in regulation of muscle adaptation;cell differentiation;response to growth factor;neurotrophin TRK receptor signaling pathway;positive regulation of nitric oxide biosynthetic process;heart contraction;response to mechanical stimulus;amine transport;muscle structure development;cardiac muscle cell development;regulation of extracellular matrix assembly;nucleobase-containing compound metabolic process;regulation of blood vessel size;endocrine process;JAK-STAT cascade;positive regulation of cellular protein metabolic process;epithelial tube morphogenesis;developmental process;multicellular organismal process;regulation of extracellular matrix organization;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of extracellular matrix organization;nephron epithelium development;mesonephric epithelium development;mesonephric tubule development;protein processing;protein targeting to nucleus;renal system development;regulation of localization;tissue remodeling;nephron development;mineralocorticoid secretion;cellular response to growth factor stimulus;protein maturation;regulation of excretion;regulation of RNA metabolic process;positive regulation of RNA metabolic process;brain renin-angiotensin system;regulation of blood vessel size by renin-angiotensin;regulation of extracellular matrix constituent secretion;positive regulation of cytokine production;protein localization to nucleus;vascular smooth muscle contraction;heart development;mesonephric tubule morphogenesis;regulation of aldosterone secretion;regulation of mineralocorticoid secretion;branching morphogenesis of an epithelial tube;reactive nitrogen species metabolic process;negative regulation of multicellular organismal process;regulation of ion transport;positive regulation of gene expression;negative regulation of transport;regulation of gene expression;positive regulation of transport;regulation of angiogenesis;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;steroid esterification;sterol esterification;cholesterol esterification;tissue morphogenesis;organic substance transport;regulation of renal sodium excretion;renal sodium excretion;positive regulation of renal sodium excretion;renal tubule morphogenesis;regulation of cell migration;positive regulation of JAK-STAT cascade;cardiac conduction;regulation of JAK-STAT cascade;cellular protein localization;nucleocytoplasmic transport;signal release;regulation of phosphorus metabolic process;ion transmembrane transport;biosynthetic process;macromolecule biosynthetic process;nuclear import;regulation of nitrogen compound metabolic process;establishment of localization in cell;localization;single-organism localization;cellular localization;muscle adaptation;single-organism intracellular transport;single-organism cellular localization;regulation of angiotensin levels in blood;angiotensin maturation;regulation of primary metabolic process;norepinephrine transport;positive regulation of vasodilation;regulation of renal system process;organ growth;sodium ion homeostasis;negative regulation of ion transmembrane transport;regulation of hormone secretion;regulation of transmembrane transport;negative regulation of transmembrane transport;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to wounding;peptidyl-amino acid modification;negative regulation of peptidase activity;positive regulation of lipid metabolic process;cellular homeostasis;positive regulation of superoxide anion generation;regulation of macromolecule metabolic process;tonic smooth muscle contraction;response to activity;artery smooth muscle contraction;regulation of proteolysis;regulation of cholesterol esterification;positive regulation of cholesterol esterification;regulation of systemic arterial blood pressure by circulatory renin-angiotensin;regulation of systemic arterial blood pressure by hormone;lipid localization;cell motility;phospholipase C-activating G-protein coupled receptor signaling pathway;activation of phospholipase C activity;chemical homeostasis;heart growth;extracellular matrix organization;aromatic compound biosynthetic process;feeding behavior;regulation of branching involved in ureteric bud morphogenesis;positive regulation of kidney development;regulation of kidney development;regulation of angiotensin metabolic process;secretion by cell;ureteric bud morphogenesis;positive regulation of ERBB signaling pathway;regulation of ERBB signaling pathway;positive regulation of oxidoreductase activity;organic substance biosynthetic process;cell growth;regulation of peptidase activity;cellular component organization;biological regulation;inorganic cation transmembrane transport;regulation of sodium ion transmembrane transporter activity;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;gap junction assembly;blood circulation;regulation of heart contraction;cell development;protein modification process;biological_process;regulation of membrane hyperpolarization;metabolic process;positive regulation of membrane hyperpolarization;positive regulation of cardiac muscle hypertrophy;regulation of neurological system process;inorganic ion transmembrane transport;smooth muscle cell proliferation;multicellular organismal signaling;lipid transport;regulation of synapse structure or activity;phosphorylation;ion homeostasis;synaptic transmission;modulation of synaptic transmission;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;negative regulation of catalytic activity;positive regulation of catalytic activity;movement of cell or subcellular component;cardiac muscle tissue development;primary metabolic process;epithelium development;positive regulation of cell differentiation;cellular monovalent inorganic cation homeostasis;regulation of cell differentiation;metal ion transport;positive regulation of transcription, DNA-templated;cellular cation homeostasis;proteolysis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;steroid metabolic process;negative regulation of developmental process;positive regulation of NF-kappaB transcription factor activity;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of cellular protein metabolic process;aging;cellular amide metabolic process;positive regulation of developmental process;female pregnancy;macromolecule metabolic process;positive regulation of steroid metabolic process;nitrogen compound metabolic process;regulation of STAT cascade;negative regulation of proteolysis;positive regulation of protein kinase activity;positive regulation of STAT cascade;positive regulation of nucleic acid-templated transcription;RNA biosynthetic process;second-messenger-mediated signaling;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular response to external stimulus;nephron tubule morphogenesis;positive regulation of cell death;regulation of cell death;kidney epithelium development;cytokine secretion;morphogenesis of an epithelium;plasma lipoprotein particle organization;growth;regulation of cellular component biogenesis;regulation of growth;cardiac muscle cell differentiation;sodium ion transport;gene expression;positive regulation of reactive oxygen species biosynthetic process;positive regulation of macrophage derived foam cell differentiation;regulation of reactive oxygen species biosynthetic process;macrophage derived foam cell differentiation;regulation of macrophage derived foam cell differentiation;regulation of tissue remodeling;negative regulation of tissue remodeling;stress-activated MAPK cascade;cell communication;negative regulation of protein metabolic process;cation transmembrane transport;stress-activated protein kinase signaling cascade;positive regulation of blood pressure;positive regulation of phospholipase activity;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;regulation of phospholipase activity;positive regulation of cellular component biogenesis; 6;6;5;4;4;5;5;4;7;3;4;2;5;4;8;7;5;6;6;7;3;5;4;7;7;6;3;4;5;4;3;6;5;5;5;4;6;9;2;4;6;6;6;6;4;6;9;4;3;4;5;5;5;4;5;6;4;5;5;5;4;5;5;5;4;6;3;5;5;4;4;8;3;5;6;5;6;5;7;4;5;6;4;5;3;8;4;6;5;4;5;5;6;6;4;6;5;5;5;7;5;5;7;5;4;5;6;8;4;4;5;4;5;4;4;4;6;5;6;6;5;6;4;5;7;5;5;6;6;3;4;3;5;8;5;2;4;4;5;5;3;6;7;7;3;5;5;5;4;4;5;4;4;3;3;4;4;4;9;2;4;4;4;4;5;5;6;5;7;5;5;3;3;5;4;5;4;4;6;5;7;3;4;5;5;6;6;5;6;4;2;8;4;3;6;6;5;5;5;4;5;7;7;6;5;5;4;4;4;3;8;9;5;6;4;6;4;3;6;4;4;4;3;3;3;5;6;5;5;2;5;6;4;4;4;5;3;7;6;4;4;5;4;5;4;6;4;6;5;4;4;3;2;4;4;5;4;5;5;4;4;4;6;5;7;4;6;5;4;4;3;6;8;6;4;5;6;8;8;6;5;6;6;6;6;7;6;4;5;6;5;5;5;4;4;6;6;4;5;7;8;6;5;7;5;5;6;5;7;5;4;4;2;8;8;4;3;4;7;3;5;7;3;5;8;9;5;6;6;3;5;7;3;3;3;6;3;5;5;5;5;2;4;4;4;5;4;6;4;4;2;2;4;4;6;6;4;5;5;6;4;4;9;4;3;3;3;4;4;3;3;8;8;5;8;4;7;9;10;9;4;4;4;5;7;5;5;3;5;6;6;7;6;6;5;5;6;4;4;4;4;3;5;6;5;4;9;5;4;5;3;5;5;5;5;7;6;5;5;5;4;6;5;7;6;6;5;5;6;4;3;4;5;5;7;6;6;4;5;4;6;4;4;6;4;7;5;5;2;2;5;2;4;7;5;5;6;5;6;5;5;3;4;4;8;6;5;5;5;5;6;7;6;4;7;7;4;6;7;7;5;4;3;5;5;3;5;3;5;5;3;5;6;7;8;4;5;5;5;4;6;5;7;5;7;5;7;5;5;5;3;5;8;4;4;2;3;3;3;5;4;5;5;4;7;5;5;4;9;5;4;4;4;4;4;4;4;7;7;4;4;6;4;7;3;8;6;5;5;7;5;4;3;6;10;5;5;5;5;3;5;4;5;6;4;7;5;5;4;4;3;6;3;2;7;7;3;3;4;7;5;6;4;5;1;3;2;3;5;5;6;5;4;5;4;6;6;8;4;3;4;4;2;4;5;3;4;3;5;5;4;5;3;5;4;8;4;7;6;7;5;7;5;4;5;3;6;5;5;4;5;3;4;4;5;3;6;6;8;6;7;6;6;5;5;4;4;4;5;4;6;4;4;5;5;5;4;2;3;3;6;8;5;5;5;5;7;5;4;4;6;4;5;6;5;5;8;5;7;7;7;3; GO:0044424;GO:0044421;GO:0044464;GO:0005615;GO:0070062;GO:0043230;GO:0072562;GO:0043226;GO:0005622;GO:0031982;GO:0005737;GO:0043227;GO:1903561;GO:0005623;GO:0005575;GO:0005576; intracellular part;extracellular region part;cell part;extracellular space;extracellular exosome;extracellular organelle;blood microparticle;organelle;intracellular;vesicle;cytoplasm;membrane-bounded organelle;extracellular vesicle;cell;cellular_component;extracellular region; 3;2;2;3;4;3;3;2;3;4;4;3;3;2;1;2; GO:0098772;GO:0005488;GO:0031702;GO:0008083;GO:0017080;GO:0004857;GO:0005515;GO:0005102;GO:0008047;GO:0016247;GO:0061135;GO:0061134;GO:0030414;GO:0016176;GO:0003674;GO:0031701;GO:0004866;GO:0004867;GO:0030234;GO:0001664;GO:0005179;GO:0031703; molecular function regulator;binding;type 1 angiotensin receptor binding;growth factor activity;sodium channel regulator activity;enzyme inhibitor activity;protein binding;receptor binding;enzyme activator activity;channel regulator activity;endopeptidase regulator activity;peptidase regulator activity;peptidase inhibitor activity;superoxide-generating NADPH oxidase activator activity;molecular_function;angiotensin receptor binding;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;enzyme regulator activity;G-protein coupled receptor binding;hormone activity;type 2 angiotensin receptor binding; 2;2;7;5;4;4;3;4;4;3;5;4;5;5;1;6;6;7;3;5;5;7; K09821 map04614;map04924; Renin-angiotensin system;Renin secretion; IPR023795;IPR000215;IPR023796;IPR033834;IPR000227; Serpin, conserved site;Serpin family;Serpin domain;Angiotensinogen serpin domain;Angiotensinogen; extracellular Hs4557287 996.0 V [V] Defense mechanisms; Q9H867 Protein-lysine methyltransferase METTL21D OS=Homo sapiens OX=9606 GN=VCPKMT PE=1 SV=2 - [MT21D_HUMAN] 0.985 1.257 1 0.604 1.386 0.497 0.783611774 0.008570977 0.435786436 5.42E-05 0.795544948 0.0669962 0.358585859 0.00023716 GO:0006479;GO:0018023;GO:0018022;GO:0008213;GO:0044237;GO:0043170;GO:0044267;GO:0044260;GO:0018193;GO:0071704;GO:0032259;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0018205;GO:0043414; protein methylation;peptidyl-lysine trimethylation;peptidyl-lysine methylation;protein alkylation;cellular metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;peptidyl-amino acid modification;organic substance metabolic process;methylation;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;peptidyl-lysine modification;macromolecule methylation; 5;7;6;7;3;4;5;4;7;3;3;2;6;5;5;1;2;3;4;8;4; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0016278;GO:0016279;GO:0008276;GO:0003674;GO:0008168;GO:0016740;GO:0016741;GO:0008757;GO:0003824;GO:0008170; lysine N-methyltransferase activity;protein-lysine N-methyltransferase activity;protein methyltransferase activity;molecular_function;methyltransferase activity;transferase activity;transferase activity, transferring one-carbon groups;S-adenosylmethionine-dependent methyltransferase activity;catalytic activity;N-methyltransferase activity; 7;7;6;1;5;3;4;6;2;6; K21806 IPR029063;IPR019410; S-adenosyl-L-methionine-dependent methyltransferase;Lysine methyltransferase; cytosol Hs13375725 246.0 A [A] RNA processing and modification; Q8NG11 Tetraspanin-14 OS=Homo sapiens OX=9606 GN=TSPAN14 PE=1 SV=1 - [TSN14_HUMAN] 0.991 1.176 0.871 1.041 1.027 1.005 0.842687075 5.87E-07 1.013631938 0.963617036 0.740646259 1.67E-11 0.978578384 0.075498018 GO:0033036;GO:0008104;GO:0051234;GO:0044802;GO:0048583;GO:0023056;GO:0061024;GO:0007009;GO:0007166;GO:0023051;GO:0071840;GO:0010647;GO:0010646;GO:0050789;GO:1902580;GO:0051716;GO:0007219;GO:0045747;GO:0009966;GO:0009967;GO:0010256;GO:0016043;GO:0090002;GO:0071704;GO:0010467;GO:0065007;GO:0044699;GO:0048518;GO:0023052;GO:0034613;GO:0048584;GO:0044700;GO:1990778;GO:0009987;GO:0050794;GO:0045184;GO:0008150;GO:0072657;GO:0008152;GO:0007154;GO:0072659;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0008593;GO:0051604;GO:0019538;GO:0090150;GO:0050896;GO:0070727;GO:0043170;GO:0044763;GO:0048522;GO:0007165; macromolecule localization;protein localization;establishment of localization;single-organism membrane organization;regulation of response to stimulus;positive regulation of signaling;membrane organization;plasma membrane organization;cell surface receptor signaling pathway;regulation of signaling;cellular component organization or biogenesis;positive regulation of cell communication;regulation of cell communication;regulation of biological process;single-organism cellular localization;cellular response to stimulus;Notch signaling pathway;positive regulation of Notch signaling pathway;regulation of signal transduction;positive regulation of signal transduction;endomembrane system organization;cellular component organization;establishment of protein localization to plasma membrane;organic substance metabolic process;gene expression;biological regulation;single-organism process;positive regulation of biological process;signaling;cellular protein localization;positive regulation of response to stimulus;single organism signaling;protein localization to cell periphery;cellular process;regulation of cellular process;establishment of protein localization;biological_process;protein localization to membrane;metabolic process;cell communication;protein localization to plasma membrane;localization;single-organism localization;cellular localization;primary metabolic process;regulation of Notch signaling pathway;protein maturation;protein metabolic process;establishment of protein localization to membrane;response to stimulus;cellular macromolecule localization;macromolecule metabolic process;single-organism cellular process;positive regulation of cellular process;signal transduction; 3;4;3;4;3;3;4;5;5;3;2;4;4;2;4;3;6;5;4;4;4;3;6;3;5;2;2;2;2;5;3;3;6;2;3;4;1;5;2;4;6;2;3;3;3;5;5;4;5;2;4;4;3;3;4; GO:0005887;GO:0097197;GO:0071944;GO:0031226;GO:0031224;GO:0016021;GO:0016020;GO:0044459;GO:0009986;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044425; integral component of plasma membrane;tetraspanin-enriched microdomain;cell periphery;intrinsic component of plasma membrane;intrinsic component of membrane;integral component of membrane;membrane;plasma membrane part;cell surface;plasma membrane;cell part;cell;cellular_component;membrane part; 4;4;3;4;3;4;2;3;3;3;2;2;1;2; GO:0019899;GO:0003674;GO:0005488;GO:0005515; enzyme binding;molecular_function;binding;protein binding; 4;1;2;3; K17296 IPR000301;IPR018499;IPR008952;IPR018503; Tetraspanin;Tetraspanin/Peripherin;Tetraspanin, EC2 domain;Tetraspanin, conserved site; plasma membrane Hs13569889 550.0 R [R] General function prediction only; Q9H2T7 Ran-binding protein 17 OS=Homo sapiens OX=9606 GN=RANBP17 PE=2 SV=1 - [RBP17_HUMAN] 1.156 1.062 0.57 1.693 1.011 0.7 1.088512241 nan 1.674579624 nan 0.536723164 nan 0.692383778 nan GO:0051169;GO:0008104;GO:0051168;GO:0070727;GO:0033036;GO:0006606;GO:0006605;GO:0045184;GO:0006611;GO:0006886;GO:0006810;GO:0008150;GO:0051236;GO:0051234;GO:0050658;GO:0046907;GO:0050657;GO:0015931;GO:0044699;GO:1902593;GO:0072594;GO:0017038;GO:0044744;GO:0033365;GO:0034504;GO:0051028;GO:0071705;GO:0071702;GO:0006403;GO:0034613;GO:0006913;GO:0044765;GO:0051170;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0015031;GO:1902582;GO:1902580; nuclear transport;protein localization;nuclear export;cellular macromolecule localization;macromolecule localization;protein import into nucleus;protein targeting;establishment of protein localization;protein export from nucleus;intracellular protein transport;transport;biological_process;establishment of RNA localization;establishment of localization;RNA transport;intracellular transport;nucleic acid transport;nucleobase-containing compound transport;single-organism process;single-organism nuclear import;establishment of protein localization to organelle;protein import;protein targeting to nucleus;protein localization to organelle;protein localization to nucleus;mRNA transport;nitrogen compound transport;organic substance transport;RNA localization;cellular protein localization;nucleocytoplasmic transport;single-organism transport;nuclear import;establishment of localization in cell;localization;single-organism localization;cellular localization;protein transport;single-organism intracellular transport;single-organism cellular localization; 6;4;8;4;3;5;6;4;6;6;4;1;4;3;5;5;7;6;2;6;5;5;5;6;7;6;5;5;4;5;7;4;8;4;2;3;3;5;5;4; GO:0031975;GO:0031967;GO:0043231;GO:0044428;GO:0044424;GO:0044422;GO:0044464;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0005643;GO:0044446;GO:0005737;GO:0005634;GO:0005635;GO:0005623;GO:0005622;GO:0005575; envelope;organelle envelope;intracellular membrane-bounded organelle;nuclear part;intracellular part;organelle part;cell part;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;nuclear pore;intracellular organelle part;cytoplasm;nucleus;nuclear envelope;cell;intracellular;cellular_component; 3;4;4;4;3;2;2;3;3;2;3;5;3;4;5;4;2;3;1; GO:0031267;GO:1901363;GO:0000166;GO:0097367;GO:0003674;GO:0005488;GO:0005487;GO:1901265;GO:0008565;GO:0032549;GO:0017076;GO:0005525;GO:0043168;GO:0017016;GO:0022892;GO:0097159;GO:0019001;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0019899;GO:0043167;GO:0032561;GO:0008536;GO:0051020;GO:0005515;GO:0001883;GO:0001882;GO:0005215;GO:0036094;GO:0005049; small GTPase binding;heterocyclic compound binding;nucleotide binding;carbohydrate derivative binding;molecular_function;binding;nucleocytoplasmic transporter activity;nucleoside phosphate binding;protein transporter activity;ribonucleoside binding;purine nucleotide binding;GTP binding;anion binding;Ras GTPase binding;substrate-specific transporter activity;organic cyclic compound binding;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;enzyme binding;ion binding;guanyl ribonucleotide binding;Ran GTPase binding;GTPase binding;protein binding;purine nucleoside binding;nucleoside binding;transporter activity;small molecule binding;nuclear export signal receptor activity; 6;3;4;3;1;2;3;4;4;5;5;6;4;7;3;3;6;5;6;4;5;4;3;6;8;5;3;5;4;2;3;4; IPR001494;IPR016024;IPR011989; Importin-beta, N-terminal domain;Armadillo-type fold;Armadillo-like helical; cytosol Hs12597633 2251.0 YU [Y] Nuclear structure;[U] Intracellular trafficking, secretion, and vesicular transport; O15050 TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=4 - [TRNK1_HUMAN] 1.07 0.85 0.797 2.025 0.73 0.809 1.258823529 0.00520568 2.773972603 0.003659704 0.937647059 0.860584963 1.108219178 0.247276794 GO:0043168;GO:0017076;GO:0030554;GO:0097367;GO:0097159;GO:0005524;GO:1901363;GO:0001882;GO:0043167;GO:0036094;GO:0035639;GO:0032559;GO:0032553;GO:0001883;GO:0032549;GO:0032555;GO:0003674;GO:0000166;GO:0032550;GO:1901265;GO:0005488; anion binding;purine nucleotide binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;ATP binding;heterocyclic compound binding;nucleoside binding;ion binding;small molecule binding;purine ribonucleoside triphosphate binding;adenyl ribonucleotide binding;ribonucleotide binding;purine nucleoside binding;ribonucleoside binding;purine ribonucleotide binding;molecular_function;nucleotide binding;purine ribonucleoside binding;nucleoside phosphate binding;binding; 4;5;6;3;3;6;3;4;3;3;5;6;4;5;5;5;1;4;6;4;2; IPR002110;IPR019734;IPR020683;IPR011990;IPR013026;IPR027417; Ankyrin repeat;Tetratricopeptide repeat;Ankyrin repeat-containing domain;Tetratricopeptide-like helical domain;Tetratricopeptide repeat-containing domain;P-loop containing nucleoside triphosphate hydrolase; nucleus 428769698 127.0 R [R] General function prediction only; COG0457 Tetratricopeptide (TPR) repeat P01011 Alpha-1-antichymotrypsin OS=Homo sapiens OX=9606 GN=SERPINA3 PE=1 SV=2 - [AACT_HUMAN] 0.965 0.908 1.144 1.007 0.905 1.109 1.06277533 5.05E-11 1.112707182 1.20E-45 1.259911894 1.25E-92 1.225414365 8.07E-44 GO:0080090;GO:0019222;GO:0060249;GO:0044710;GO:0010605;GO:0044092;GO:0048519;GO:0060255;GO:0030162;GO:0003008;GO:0044707;GO:0019538;GO:0022600;GO:0043170;GO:0050789;GO:0044267;GO:0051346;GO:0044260;GO:0019216;GO:0052548;GO:0065007;GO:0065009;GO:0065008;GO:0006629;GO:0050790;GO:0050794;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0030277;GO:0006954;GO:0002526;GO:0051336;GO:0050896;GO:0008152;GO:0009892;GO:0043086;GO:0044699;GO:0051248;GO:0051246;GO:0006508;GO:0032501;GO:0009987;GO:0001894;GO:0032269;GO:0032268;GO:0048871;GO:0045861;GO:0031324;GO:0031323;GO:0042592;GO:0010669;GO:0071704;GO:0010466;GO:0052547;GO:0007586;GO:0010951;GO:0044238;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;anatomical structure homeostasis;single-organism metabolic process;negative regulation of macromolecule metabolic process;negative regulation of molecular function;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of proteolysis;system process;single-multicellular organism process;protein metabolic process;digestive system process;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of lipid metabolic process;regulation of endopeptidase activity;biological regulation;regulation of molecular function;regulation of biological quality;lipid metabolic process;regulation of catalytic activity;regulation of cellular process;defense response;acute-phase response;response to stress;biological_process;maintenance of gastrointestinal epithelium;inflammatory response;acute inflammatory response;regulation of hydrolase activity;response to stimulus;metabolic process;negative regulation of metabolic process;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;proteolysis;multicellular organismal process;cellular process;tissue homeostasis;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;multicellular organismal homeostasis;negative regulation of proteolysis;negative regulation of cellular metabolic process;regulation of cellular metabolic process;homeostatic process;epithelial structure maintenance;organic substance metabolic process;negative regulation of peptidase activity;regulation of peptidase activity;digestion;negative regulation of endopeptidase activity;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 4;3;5;3;4;4;2;4;6;3;3;4;4;4;2;5;6;4;5;7;2;3;3;4;4;3;4;7;3;1;5;5;6;5;2;2;3;5;2;5;5;5;2;2;5;5;5;4;6;4;4;4;6;3;7;6;4;8;3;3;3; GO:0031982;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0043229;GO:0043227;GO:0072562;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;intracellular organelle;membrane-bounded organelle;blood microparticle;nucleus;cell part;cell;intracellular;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;3;4;3;2;3;3;3;5;2;2;3;4;2;3;3;1;2; GO:0098772;GO:1901363;GO:0004866;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0030234;GO:0097159;GO:0004857;GO:0030414;GO:0004867;GO:0061135;GO:0061134; molecular function regulator;heterocyclic compound binding;endopeptidase inhibitor activity;molecular_function;binding;nucleic acid binding;DNA binding;enzyme regulator activity;organic cyclic compound binding;enzyme inhibitor activity;peptidase inhibitor activity;serine-type endopeptidase inhibitor activity;endopeptidase regulator activity;peptidase regulator activity; 2;3;6;1;2;4;5;3;3;4;5;7;5;4; K04525 IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; extracellular Hs14748212 872.0 V [V] Defense mechanisms; Q9NXD2 Myotubularin-related protein 10 OS=Homo sapiens OX=9606 GN=MTMR10 PE=1 SV=3 - [MTMRA_HUMAN] 1.091 1.026 1.004 1.147 0.927 1.063 1.063352827 nan 1.237324703 nan 0.978557505 nan 1.146709817 nan K18085 IPR029021;IPR030573;IPR030564;IPR010569;IPR011993;IPR035660;IPR022587; Protein-tyrosine phosphatase-like;Myotubularin-related protein 10;Myotubularin family;Myotubularin-like phosphatase domain;PH domain-like;Myotubularin-related protein 10, PH-GRAM domain;Myotubularin-related 12-like C-terminal domain; nucleus Hs8923297 907.0 R [R] General function prediction only; P30260 Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2 - [CDC27_HUMAN] 0.922 0.989 1.256 0.948 1.048 0.887 0.932254803 0.391026902 0.904580153 0.029568439 1.269969666 0.060334622 0.846374046 0.110398149 GO:0051348;GO:0080090;GO:0019222;GO:0032435;GO:0051985;GO:2000058;GO:0010965;GO:0071840;GO:0045786;GO:0032434;GO:0070647;GO:0032446;GO:0051246;GO:1901799;GO:0044092;GO:0048518;GO:0048519;GO:0007088;GO:0010605;GO:0060255;GO:0030162;GO:0030163;GO:1902099;GO:0019538;GO:0010639;GO:0051352;GO:0051783;GO:0016567;GO:0051784;GO:0044784;GO:0045841;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0009896;GO:0051351;GO:0007067;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0051347;GO:0044260;GO:0051782;GO:1903363;GO:0016043;GO:0043086;GO:0051129;GO:0065007;GO:0007049;GO:0065009;GO:0071174;GO:0071173;GO:0050790;GO:0031397;GO:0050794;GO:1901987;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0045862;GO:0007059;GO:1901988;GO:0010604;GO:0051444;GO:0051603;GO:0051443;GO:0031400;GO:0031401;GO:0010498;GO:0051338;GO:0045732;GO:0006511;GO:1903051;GO:2001251;GO:0033044;GO:0033045;GO:0033046;GO:0033047;GO:0043085;GO:0033043;GO:0000280;GO:0033048;GO:0051128;GO:0044248;GO:0042176;GO:0042177;GO:1901991;GO:1901990;GO:0000209;GO:0044699;GO:0051248;GO:0070979;GO:0043161;GO:0010564;GO:0051247;GO:1903320;GO:1903321;GO:1903322;GO:0032270;GO:0031398;GO:0031399;GO:0031396;GO:0006508;GO:2000060;GO:0044093;GO:0008283;GO:0031330;GO:0031331;GO:1903050;GO:0009987;GO:0019941;GO:0031145;GO:0045839;GO:0044257;GO:0051983;GO:0032269;GO:0032268;GO:0000819;GO:0098813;GO:0010948;GO:0043170;GO:0030071;GO:1903052;GO:0051439;GO:0045861;GO:0051437;GO:2000816;GO:0031329;GO:0031325;GO:0031324;GO:0031323;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0051438;GO:0051306;GO:0043632;GO:0051304;GO:0051436;GO:0051302;GO:0051301;GO:0071704;GO:0042787;GO:1904666;GO:1904667;GO:1904668;GO:1903364;GO:0045930;GO:0000278;GO:1903362;GO:0031577;GO:0061136;GO:0007346;GO:0006464;GO:0051340;GO:0044763;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0000070;GO:0051276;GO:0000075;GO:0051726;GO:0044237;GO:1902589;GO:0048285;GO:1902100;GO:0007094;GO:0048522;GO:0007091;GO:0048523;GO:0007093; negative regulation of transferase activity;regulation of primary metabolic process;regulation of metabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of chromosome segregation;regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of mitotic sister chromatid separation;cellular component organization or biogenesis;negative regulation of cell cycle;regulation of proteasomal ubiquitin-dependent protein catabolic process;protein modification by small protein conjugation or removal;protein modification by small protein conjugation;regulation of protein metabolic process;negative regulation of proteasomal protein catabolic process;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;regulation of mitotic nuclear division;negative regulation of macromolecule metabolic process;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;regulation of metaphase/anaphase transition of cell cycle;protein metabolic process;negative regulation of organelle organization;negative regulation of ligase activity;regulation of nuclear division;protein ubiquitination;negative regulation of nuclear division;metaphase/anaphase transition of cell cycle;negative regulation of mitotic metaphase/anaphase transition;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of catabolic process;positive regulation of ligase activity;mitotic nuclear division;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;positive regulation of transferase activity;cellular macromolecule metabolic process;negative regulation of cell division;negative regulation of cellular protein catabolic process;cellular component organization;negative regulation of catalytic activity;negative regulation of cellular component organization;biological regulation;cell cycle;regulation of molecular function;mitotic spindle checkpoint;spindle assembly checkpoint;regulation of catalytic activity;negative regulation of protein ubiquitination;regulation of cellular process;regulation of cell cycle phase transition;macromolecule modification;protein modification process;biological_process;metabolic process;positive regulation of proteolysis;chromosome segregation;negative regulation of cell cycle phase transition;positive regulation of macromolecule metabolic process;negative regulation of ubiquitin-protein transferase activity;proteolysis involved in cellular protein catabolic process;positive regulation of ubiquitin-protein transferase activity;negative regulation of protein modification process;positive regulation of protein modification process;proteasomal protein catabolic process;regulation of transferase activity;positive regulation of protein catabolic process;ubiquitin-dependent protein catabolic process;negative regulation of proteolysis involved in cellular protein catabolic process;negative regulation of chromosome organization;regulation of chromosome organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;positive regulation of catalytic activity;regulation of organelle organization;nuclear division;negative regulation of mitotic sister chromatid segregation;regulation of cellular component organization;cellular catabolic process;regulation of protein catabolic process;negative regulation of protein catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;protein polyubiquitination;single-organism process;negative regulation of protein metabolic process;protein K11-linked ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of cell cycle process;positive regulation of protein metabolic process;regulation of protein modification by small protein conjugation or removal;negative regulation of protein modification by small protein conjugation or removal;positive regulation of protein modification by small protein conjugation or removal;positive regulation of cellular protein metabolic process;positive regulation of protein ubiquitination;regulation of protein modification process;regulation of protein ubiquitination;proteolysis;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;positive regulation of molecular function;cell proliferation;negative regulation of cellular catabolic process;positive regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;anaphase-promoting complex-dependent catabolic process;negative regulation of mitotic nuclear division;cellular protein catabolic process;regulation of chromosome segregation;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;sister chromatid segregation;nuclear chromosome segregation;negative regulation of cell cycle process;macromolecule metabolic process;regulation of mitotic metaphase/anaphase transition;positive regulation of proteolysis involved in cellular protein catabolic process;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;negative regulation of proteolysis;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;negative regulation of mitotic sister chromatid separation;regulation of cellular catabolic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;regulation of ubiquitin-protein transferase activity;mitotic sister chromatid separation;modification-dependent macromolecule catabolic process;chromosome separation;negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;regulation of cell division;cell division;organic substance metabolic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ubiquitin protein ligase activity;negative regulation of ubiquitin protein ligase activity;positive regulation of ubiquitin protein ligase activity;positive regulation of cellular protein catabolic process;negative regulation of mitotic cell cycle;mitotic cell cycle;regulation of cellular protein catabolic process;spindle checkpoint;regulation of proteasomal protein catabolic process;regulation of mitotic cell cycle;cellular protein modification process;regulation of ligase activity;single-organism cellular process;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;mitotic sister chromatid segregation;chromosome organization;cell cycle checkpoint;regulation of cell cycle;cellular metabolic process;single-organism organelle organization;organelle fission;negative regulation of metaphase/anaphase transition of cell cycle;mitotic spindle assembly checkpoint;positive regulation of cellular process;metaphase/anaphase transition of mitotic cell cycle;negative regulation of cellular process;mitotic cell cycle checkpoint; 6;4;3;8;4;8;7;2;4;8;7;8;5;7;4;2;2;6;4;4;6;5;6;4;5;6;5;9;5;6;7;4;4;3;3;4;6;5;2;5;4;5;6;4;4;6;3;5;4;2;4;3;6;7;4;8;3;6;5;5;1;2;6;4;6;4;7;6;7;6;6;6;5;5;8;7;6;6;5;5;6;5;5;6;6;4;4;5;5;6;6;10;2;5;11;7;5;5;7;7;7;5;8;6;8;5;8;4;3;5;5;7;2;7;8;6;6;4;5;5;5;5;5;4;7;7;6;6;7;7;5;4;4;4;5;5;6;4;6;6;6;5;6;4;4;3;9;7;8;8;6;5;5;6;6;7;5;6;5;3;3;5;4;3;6;5;5;4;3;4;5;7;6;3;6;3;6; GO:0031974;GO:0005815;GO:0000151;GO:0031981;GO:0000152;GO:1990234;GO:0031461;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0005856;GO:0005654;GO:0044430;GO:0005680;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:1902494;GO:0005819;GO:0005813;GO:0043226;GO:0015630;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;microtubule organizing center;ubiquitin ligase complex;nuclear lumen;nuclear ubiquitin ligase complex;transferase complex;cullin-RING ubiquitin ligase complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;cytoskeleton;nucleoplasm;cytoskeletal part;anaphase-promoting complex;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;cell part;cell;catalytic complex;spindle;centrosome;organelle;microtubule cytoskeleton;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;5;5;5;5;3;4;4;3;5;4;3;2;3;3;3;3;5;5;4;6;3;4;4;5;2;2;4;5;5;2;6;2;1;4; GO:0019903;GO:0019902;GO:0003674;GO:0005488;GO:0019899;GO:0005515; protein phosphatase binding;phosphatase binding;molecular_function;binding;enzyme binding;protein binding; 6;5;1;2;4;3; K03350 map04110;map04111;map04113;map04114;map04120;map04914;map05166; Cell cycle;Cell cycle - yeast;Meiosis - yeast;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;HTLV-I infection; IPR001440;IPR019734;IPR013026;IPR011990; Tetratricopeptide repeat 1;Tetratricopeptide repeat;Tetratricopeptide repeat-containing domain;Tetratricopeptide-like helical domain; nucleus Hs16554577 1716.0 D [D] Cell cycle control, cell division, chromosome partitioning; P17081 Rho-related GTP-binding protein RhoQ OS=Homo sapiens OX=9606 GN=RHOQ PE=1 SV=2 - [RHOQ_HUMAN] 0.82 1.933 0.892 1.025 0.887 nan 0.424211071 nan 1.155580609 nan 0.461458872 nan nan nan GO:0006366;GO:0008104;GO:0019222;GO:0051049;GO:0048583;GO:0061024;GO:0007009;GO:0007165;GO:0007166;GO:0009966;GO:0007169;GO:0090005;GO:0032989;GO:0090003;GO:0090002;GO:0071840;GO:0031346;GO:0051716;GO:0046128;GO:0051254;GO:0070727;GO:0048869;GO:0051493;GO:0010467;GO:0051491;GO:0048518;GO:0048519;GO:0033036;GO:0009205;GO:0046039;GO:0010556;GO:0051050;GO:0060255;GO:0045184;GO:0010628;GO:0008360;GO:0072657;GO:2001141;GO:0043434;GO:0072659;GO:0010033;GO:0046483;GO:0044700;GO:0065008;GO:1901564;GO:0044089;GO:0010243;GO:0006355;GO:0060491;GO:0006163;GO:0007154;GO:1903508;GO:0046847;GO:0044281;GO:0022604;GO:0022607;GO:0034645;GO:0009141;GO:0007167;GO:0009144;GO:0046323;GO:0006807;GO:0046324;GO:0046326;GO:0035556;GO:0043170;GO:0050789;GO:1901576;GO:0010646;GO:0000902;GO:0044260;GO:0008645;GO:0018130;GO:0016043;GO:0008643;GO:1901068;GO:0065007;GO:1901360;GO:1903828;GO:0031344;GO:0009150;GO:0051130;GO:0070201;GO:0034613;GO:0050793;GO:0006810;GO:0009889;GO:0044710;GO:0050794;GO:0019637;GO:0044802;GO:1903729;GO:0032956;GO:0034654;GO:0051234;GO:0044238;GO:0016070;GO:0044767;GO:0044271;GO:1901698;GO:1901699;GO:0030866;GO:0030865;GO:0006357;GO:0008150;GO:0006753;GO:0008152;GO:0033043;GO:0010256;GO:0051173;GO:0009117;GO:0051129;GO:0051128;GO:1903827;GO:0044249;GO:0034641;GO:0023052;GO:0019438;GO:0070887;GO:0023051;GO:1904950;GO:1990778;GO:0009259;GO:0044699;GO:0032880;GO:0009719;GO:0006139;GO:1902531;GO:0071375;GO:0010557;GO:0009653;GO:0042278;GO:0009199;GO:0031326;GO:0009893;GO:0071495;GO:0006996;GO:0008286;GO:0051489;GO:0031323;GO:0009987;GO:1904376;GO:1903506;GO:1904375;GO:0009058;GO:0032870;GO:0045893;GO:0032879;GO:0009891;GO:0055086;GO:0009725;GO:1901135;GO:0051252;GO:1902680;GO:0045944;GO:0050896;GO:0032502;GO:0032774;GO:0060341;GO:0051056;GO:0030030;GO:0030031;GO:0031325;GO:0010604;GO:0030036;GO:0090304;GO:0010827;GO:0031328;GO:0019693;GO:0072521;GO:0032869;GO:0032868;GO:0010828;GO:1901657;GO:0051171;GO:0071417;GO:2000112;GO:0006796;GO:0015758;GO:0071704;GO:0071310;GO:0022603;GO:0097659;GO:0071702;GO:0010468;GO:0006351;GO:0032970;GO:0045935;GO:0030029;GO:0019219;GO:0006725;GO:1903076;GO:1903077;GO:0080090;GO:0044765;GO:0009059;GO:0044763;GO:0009116;GO:0042221;GO:0009119;GO:0007264;GO:0051179;GO:1902578;GO:0051641;GO:1901700;GO:1901701;GO:0007010;GO:1901362;GO:0090150;GO:0048856;GO:0044237;GO:0044087;GO:1902589;GO:0044085;GO:1901652;GO:1901653;GO:0015749;GO:0006793;GO:1902580;GO:0048523;GO:0048522; transcription from RNA polymerase II promoter;protein localization;regulation of metabolic process;regulation of transport;regulation of response to stimulus;membrane organization;plasma membrane organization;signal transduction;cell surface receptor signaling pathway;regulation of signal transduction;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of establishment of protein localization to plasma membrane;cellular component morphogenesis;regulation of establishment of protein localization to plasma membrane;establishment of protein localization to plasma membrane;cellular component organization or biogenesis;positive regulation of cell projection organization;cellular response to stimulus;purine ribonucleoside metabolic process;positive regulation of RNA metabolic process;cellular macromolecule localization;cellular developmental process;regulation of cytoskeleton organization;gene expression;positive regulation of filopodium assembly;positive regulation of biological process;negative regulation of biological process;macromolecule localization;purine ribonucleoside triphosphate metabolic process;GTP metabolic process;regulation of macromolecule biosynthetic process;positive regulation of transport;regulation of macromolecule metabolic process;establishment of protein localization;positive regulation of gene expression;regulation of cell shape;protein localization to membrane;regulation of RNA biosynthetic process;response to peptide hormone;protein localization to plasma membrane;response to organic substance;heterocycle metabolic process;single organism signaling;regulation of biological quality;organonitrogen compound metabolic process;positive regulation of cellular component biogenesis;response to organonitrogen compound;regulation of transcription, DNA-templated;regulation of cell projection assembly;purine nucleotide metabolic process;cell communication;positive regulation of nucleic acid-templated transcription;filopodium assembly;small molecule metabolic process;regulation of cell morphogenesis;cellular component assembly;cellular macromolecule biosynthetic process;nucleoside triphosphate metabolic process;enzyme linked receptor protein signaling pathway;purine nucleoside triphosphate metabolic process;glucose import;nitrogen compound metabolic process;regulation of glucose import;positive regulation of glucose import;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;organic substance biosynthetic process;regulation of cell communication;cell morphogenesis;cellular macromolecule metabolic process;hexose transport;heterocycle biosynthetic process;cellular component organization;carbohydrate transport;guanosine-containing compound metabolic process;biological regulation;organic cyclic compound metabolic process;negative regulation of cellular protein localization;regulation of cell projection organization;purine ribonucleotide metabolic process;positive regulation of cellular component organization;regulation of establishment of protein localization;cellular protein localization;regulation of developmental process;transport;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;organophosphate metabolic process;single-organism membrane organization;regulation of plasma membrane organization;regulation of actin cytoskeleton organization;nucleobase-containing compound biosynthetic process;establishment of localization;primary metabolic process;RNA metabolic process;single-organism developmental process;cellular nitrogen compound biosynthetic process;response to nitrogen compound;cellular response to nitrogen compound;cortical actin cytoskeleton organization;cortical cytoskeleton organization;regulation of transcription from RNA polymerase II promoter;biological_process;nucleoside phosphate metabolic process;metabolic process;regulation of organelle organization;endomembrane system organization;positive regulation of nitrogen compound metabolic process;nucleotide metabolic process;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;aromatic compound biosynthetic process;cellular response to chemical stimulus;regulation of signaling;negative regulation of establishment of protein localization;protein localization to cell periphery;ribonucleotide metabolic process;single-organism process;regulation of protein localization;response to endogenous stimulus;nucleobase-containing compound metabolic process;regulation of intracellular signal transduction;cellular response to peptide hormone stimulus;positive regulation of macromolecule biosynthetic process;anatomical structure morphogenesis;purine nucleoside metabolic process;ribonucleoside triphosphate metabolic process;regulation of cellular biosynthetic process;positive regulation of metabolic process;cellular response to endogenous stimulus;organelle organization;insulin receptor signaling pathway;regulation of filopodium assembly;regulation of cellular metabolic process;cellular process;negative regulation of protein localization to cell periphery;regulation of nucleic acid-templated transcription;regulation of protein localization to cell periphery;biosynthetic process;cellular response to hormone stimulus;positive regulation of transcription, DNA-templated;regulation of localization;positive regulation of biosynthetic process;nucleobase-containing small molecule metabolic process;response to hormone;carbohydrate derivative metabolic process;regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;response to stimulus;developmental process;RNA biosynthetic process;regulation of cellular localization;regulation of small GTPase mediated signal transduction;cell projection organization;cell projection assembly;positive regulation of cellular metabolic process;positive regulation of macromolecule metabolic process;actin cytoskeleton organization;nucleic acid metabolic process;regulation of glucose transport;positive regulation of cellular biosynthetic process;ribose phosphate metabolic process;purine-containing compound metabolic process;cellular response to insulin stimulus;response to insulin;positive regulation of glucose transport;glycosyl compound metabolic process;regulation of nitrogen compound metabolic process;cellular response to organonitrogen compound;regulation of cellular macromolecule biosynthetic process;phosphate-containing compound metabolic process;glucose transport;organic substance metabolic process;cellular response to organic substance;regulation of anatomical structure morphogenesis;nucleic acid-templated transcription;organic substance transport;regulation of gene expression;transcription, DNA-templated;regulation of actin filament-based process;positive regulation of nucleobase-containing compound metabolic process;actin filament-based process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;regulation of protein localization to plasma membrane;negative regulation of protein localization to plasma membrane;regulation of primary metabolic process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;nucleoside metabolic process;response to chemical;ribonucleoside metabolic process;small GTPase mediated signal transduction;localization;single-organism localization;cellular localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;cytoskeleton organization;organic cyclic compound biosynthetic process;establishment of protein localization to membrane;anatomical structure development;cellular metabolic process;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;response to peptide;cellular response to peptide;monosaccharide transport;phosphorus metabolic process;single-organism cellular localization;negative regulation of cellular process;positive regulation of cellular process; 7;4;3;4;3;4;5;4;5;4;7;4;4;6;6;2;5;3;7;5;4;4;6;5;4;2;2;3;8;8;5;3;4;4;5;4;5;6;5;6;4;4;3;3;4;3;4;6;4;6;4;7;6;4;5;4;5;6;6;7;9;3;6;5;5;4;2;4;4;5;4;7;5;3;5;8;2;4;3;5;7;4;5;5;3;4;4;3;3;4;4;5;5;5;3;3;5;3;5;4;5;6;6;7;1;5;2;5;4;4;6;4;4;5;4;4;2;5;4;3;3;6;6;2;4;3;4;5;6;5;3;6;7;5;3;4;4;8;5;4;2;4;7;6;3;5;6;3;4;4;4;4;5;6;7;2;2;6;4;6;4;5;4;4;5;5;5;5;5;5;7;6;4;4;4;5;6;5;8;3;5;4;7;5;5;6;4;5;4;5;4;6;5;4;4;5;3;5;3;6;6;2;3;3;4;5;5;5;5;3;3;3;4;3;5;6;6;4;4;3;3; GO:0099512;GO:0099513;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0097708;GO:0005794;GO:0098588;GO:0098589;GO:0005798;GO:0043230;GO:0043231;GO:0043232;GO:0044424;GO:0044425;GO:0005884;GO:0044421;GO:0044422;GO:0005829;GO:0043227;GO:0005856;GO:1903561;GO:0044433;GO:0044431;GO:0044430;GO:0005737;GO:0012506;GO:0030660;GO:0098857;GO:0000139;GO:0044446;GO:0044444;GO:0031090;GO:0012505;GO:0031410;GO:0030659;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0043228;GO:0045121;GO:0015629;GO:0071944;GO:0070062;GO:0043226;GO:0005576;GO:0005886;GO:0005575;GO:0098805; supramolecular fiber;polymeric cytoskeletal fiber;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;intracellular vesicle;Golgi apparatus;bounding membrane of organelle;membrane region;Golgi-associated vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;membrane part;actin filament;extracellular region part;organelle part;cytosol;membrane-bounded organelle;cytoskeleton;extracellular vesicle;cytoplasmic vesicle part;Golgi apparatus part;cytoskeletal part;cytoplasm;vesicle membrane;Golgi-associated vesicle membrane;membrane microdomain;Golgi membrane;intracellular organelle part;cytoplasmic part;organelle membrane;endomembrane system;cytoplasmic vesicle;cytoplasmic vesicle membrane;cell part;intracellular organelle;cell;intracellular;non-membrane-bounded organelle;membrane raft;actin cytoskeleton;cell periphery;extracellular exosome;organelle;extracellular region;plasma membrane;cellular_component;whole membrane; 2;3;4;5;2;5;4;4;4;3;5;3;4;4;3;2;4;2;2;5;3;5;3;4;4;4;4;4;4;4;5;3;4;3;3;5;5;2;3;2;3;3;5;6;3;4;2;2;3;1;3; GO:0032427;GO:0003924;GO:0016818;GO:0097367;GO:0019904;GO:0016787;GO:0016817;GO:0003674;GO:1901265;GO:0032549;GO:0005522;GO:0017076;GO:0005525;GO:0000166;GO:0016462;GO:0003824;GO:0097159;GO:0019001;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0032561;GO:0005515;GO:0005488;GO:1901363;GO:0001883;GO:0001882;GO:0017111;GO:0036094;GO:0043168; GBD domain binding;GTPase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;protein domain specific binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;molecular_function;nucleoside phosphate binding;ribonucleoside binding;profilin binding;purine nucleotide binding;GTP binding;nucleotide binding;pyrophosphatase activity;catalytic activity;organic cyclic compound binding;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;guanyl ribonucleotide binding;protein binding;binding;heterocyclic compound binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;anion binding; 5;8;5;3;4;3;4;1;4;5;4;5;6;4;6;2;3;6;5;6;4;5;3;6;3;2;3;5;4;7;3;4; K07194 map04910; Insulin signaling pathway; IPR003578;IPR005225;IPR027417;IPR001806; Small GTPase superfamily, Rho type;Small GTP-binding protein domain;P-loop containing nucleoside triphosphate hydrolase;Small GTPase superfamily; cytosol Hs6912696 424.0 R [R] General function prediction only; A0A0C4DH55 Immunoglobulin kappa variable 3D-7 OS=Homo sapiens OX=9606 GN=IGKV3D-7 PE=3 SV=5 - [KVD07_HUMAN] 0.981 1.004 0.967 0.936 1.097 1.256 0.977091633 0.233355606 0.853236098 0.00057771 0.96314741 0.283165394 1.144940747 0.000205331 IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9H8H2 Probable ATP-dependent RNA helicase DDX31 OS=Homo sapiens OX=9606 GN=DDX31 PE=1 SV=2 - [DDX31_HUMAN] 1.029 1.332 0.756 0.979 1.255 0.642 0.772522523 nan 0.780079681 nan 0.567567568 nan 0.511553785 nan GO:0044237;GO:0006807;GO:0090304;GO:0043170;GO:0071840;GO:0042254;GO:0071704;GO:1901360;GO:0022613;GO:0044260;GO:0010501;GO:0006139;GO:0009987;GO:0006725;GO:0008150;GO:0008152;GO:0034641;GO:0046483;GO:0016070;GO:0044238;GO:0044085; cellular metabolic process;nitrogen compound metabolic process;nucleic acid metabolic process;macromolecule metabolic process;cellular component organization or biogenesis;ribosome biogenesis;organic substance metabolic process;organic cyclic compound metabolic process;ribonucleoprotein complex biogenesis;cellular macromolecule metabolic process;RNA secondary structure unwinding;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;biological_process;metabolic process;cellular nitrogen compound metabolic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular component biogenesis; 3;3;5;4;2;5;3;4;4;4;6;4;2;4;1;2;4;4;5;3;3; GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0031981;GO:0005730;GO:0005634;GO:0005794;GO:0012505;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;nuclear lumen;nucleolus;nucleus;Golgi apparatus;endomembrane system;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part; 2;3;3;3;2;4;3;5;5;5;4;3;4;4;3;2;2;3;1;4;4;4;3;2; GO:0032550;GO:0016887;GO:0008026;GO:0016787;GO:0035639;GO:0032549;GO:0032553;GO:0003674;GO:0005488;GO:0003676;GO:0008186;GO:0001883;GO:0001882;GO:0043167;GO:1901363;GO:0003724;GO:0005524;GO:0030554;GO:0000166;GO:0044822;GO:0017111;GO:0004004;GO:0004386;GO:0036094;GO:0003824;GO:0017076;GO:0032559;GO:0032555;GO:0016818;GO:0097367;GO:0097159;GO:0042623;GO:0016817;GO:0003723;GO:0070035;GO:0016462;GO:0043168;GO:1901265; purine ribonucleoside binding;ATPase activity;ATP-dependent helicase activity;hydrolase activity;purine ribonucleoside triphosphate binding;ribonucleoside binding;ribonucleotide binding;molecular_function;binding;nucleic acid binding;RNA-dependent ATPase activity;purine nucleoside binding;nucleoside binding;ion binding;heterocyclic compound binding;RNA helicase activity;ATP binding;adenyl nucleotide binding;nucleotide binding;poly(A) RNA binding;nucleoside-triphosphatase activity;ATP-dependent RNA helicase activity;helicase activity;small molecule binding;catalytic activity;purine nucleotide binding;adenyl ribonucleotide binding;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;organic cyclic compound binding;ATPase activity, coupled;hydrolase activity, acting on acid anhydrides;RNA binding;purine NTP-dependent helicase activity;pyrophosphatase activity;anion binding;nucleoside phosphate binding; 6;8;10;3;5;5;4;1;2;4;10;5;4;3;3;9;6;6;4;6;7;10;8;3;2;5;6;5;5;3;3;9;4;5;9;6;4;4; K14806 IPR000629;IPR011545;IPR001650;IPR014014;IPR025313;IPR014001;IPR027417; ATP-dependent RNA helicase DEAD-box, conserved site;DEAD/DEAH box helicase domain;Helicase, C-terminal;RNA helicase, DEAD-box type, Q motif;Domain of unknown function DUF4217;Helicase superfamily 1/2, ATP-binding domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs17505907 1750.0 A [A] RNA processing and modification; Q9C0A6 SET domain-containing protein 5 OS=Homo sapiens OX=9606 GN=SETD5 PE=1 SV=2 - [SETD5_HUMAN] 1.419 0.828 1.026 1.28 0.727 0.722 1.713768116 nan 1.760660248 nan 1.239130435 nan 0.993122421 nan K23216 IPR001214; SET domain; nucleus 560145540 52.0 R [R] General function prediction only; COG2940 SET domain-containing protein (function unknown) Q4ZHG4 Fibronectin type III domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FNDC1 PE=2 SV=4 - [FNDC1_HUMAN] 0.914 0.657 1.903 0.745 0.74 0.633 1.391171994 0.281665847 1.006756757 0.949965357 2.896499239 0.08996173 0.855405405 0.850372978 GO:0005654;GO:0043231;GO:0031981;GO:0043233;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0043229;GO:0005576;GO:0044428;GO:0031974;GO:0005575;GO:0044424;GO:0043227;GO:0043226;GO:0044422; nucleoplasm;intracellular membrane-bounded organelle;nuclear lumen;organelle lumen;nucleus;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;intracellular organelle;extracellular region;nuclear part;membrane-enclosed lumen;cellular_component;intracellular part;membrane-bounded organelle;organelle;organelle part; 5;4;5;3;5;2;2;3;3;4;3;2;4;2;1;3;3;2;2; IPR003961;IPR013783; Fibronectin type III;Immunoglobulin-like fold; extracellular O95816 BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1 - [BAG2_HUMAN] 0.955 0.924 1.314 0.994 1.057 0.586 1.033549784 nan 0.940397351 nan 1.422077922 nan 0.554399243 nan GO:0006457;GO:0034605;GO:0048583;GO:0050789;GO:0051716;GO:0071704;GO:0065007;GO:0009628;GO:0009987;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0009266;GO:0009408;GO:0044238;GO:0019538;GO:1900034;GO:0080134;GO:0080135;GO:0043170;GO:0033554;GO:0050896; protein folding;cellular response to heat;regulation of response to stimulus;regulation of biological process;cellular response to stimulus;organic substance metabolic process;biological regulation;response to abiotic stimulus;cellular process;regulation of cellular process;response to stress;biological_process;metabolic process;response to temperature stimulus;response to heat;primary metabolic process;protein metabolic process;regulation of cellular response to heat;regulation of response to stress;regulation of cellular response to stress;macromolecule metabolic process;cellular response to stress;response to stimulus; 3;5;3;2;3;3;2;3;2;3;3;1;2;4;4;3;4;5;4;4;4;4;2; GO:0005829;GO:0005622;GO:0005737;GO:0044464;GO:0005623;GO:0005575;GO:0044444;GO:0044424; cytosol;intracellular;cytoplasm;cell part;cell;cellular_component;cytoplasmic part;intracellular part; 5;3;4;2;2;1;4;3; GO:0003674;GO:0005488;GO:0042802;GO:0005515; molecular_function;binding;identical protein binding;protein binding; 1;2;4;3; K09556 map04141; Protein processing in endoplasmic reticulum; IPR003103; BAG domain; cytosol Hs4757834 428.0 O [O] Posttranslational modification, protein turnover, chaperones; P34896 Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1 - [GLYC_HUMAN] 1.099 1.562 0.624 0.879 1.337 nan 0.703585147 nan 0.657442034 nan 0.399487836 nan nan nan GO:0051289;GO:0009219;GO:0009165;GO:0009162;GO:0042558;GO:0044282;GO:0044283;GO:1901362;GO:0071840;GO:0044712;GO:0044710;GO:0044711;GO:0042440;GO:0006545;GO:0006544;GO:0010033;GO:0006767;GO:0006766;GO:0006760;GO:0032787;GO:0009177;GO:0009176;GO:0043436;GO:1901564;GO:0009070;GO:0009071;GO:0046483;GO:0043648;GO:0006575;GO:1901566;GO:0006577;GO:0006578;GO:0016054;GO:0016053;GO:1901137;GO:0019438;GO:0044281;GO:0022607;GO:0009063;GO:0006807;GO:0045329;GO:0046653;GO:0046655;GO:0072330;GO:1901576;GO:1901575;GO:0051186;GO:0006563;GO:0097164;GO:0035999;GO:0016043;GO:0006221;GO:0065003;GO:1901360;GO:0019637;GO:0018130;GO:0009719;GO:0009157;GO:1904481;GO:1904482;GO:0051716;GO:0009263;GO:0009262;GO:0008150;GO:0008152;GO:0034654;GO:0090407;GO:0046148;GO:0044271;GO:0046394;GO:0046395;GO:0050896;GO:1901699;GO:0043603;GO:0009117;GO:0006753;GO:1901617;GO:1901565;GO:0070271;GO:0006732;GO:0006730;GO:0044248;GO:0044249;GO:0034641;GO:0009129;GO:0070887;GO:0009123;GO:0044699;GO:0006139;GO:0046385;GO:0008652;GO:1901605;GO:1901606;GO:0071495;GO:1901701;GO:0009987;GO:0006725;GO:0046073;GO:0001101;GO:0009130;GO:0055086;GO:0051259;GO:0006082;GO:0071407;GO:1901135;GO:0014070;GO:0019264;GO:1901607;GO:0009081;GO:1901698;GO:0009083;GO:0006220;GO:0009124;GO:0043933;GO:0019752;GO:0071229;GO:0072528;GO:0009437;GO:0046112;GO:0072521;GO:0072522;GO:0019692;GO:0009069;GO:0072527;GO:0071822;GO:0071417;GO:0006520;GO:0051260;GO:0051262;GO:0071704;GO:0071310;GO:1901293;GO:0006231;GO:0006461;GO:0009221;GO:0006565;GO:0009113;GO:0009112;GO:0009058;GO:0044763;GO:0010243;GO:0042221;GO:0009056;GO:1901700;GO:0044238;GO:0009265;GO:0009394;GO:0044237;GO:0006796;GO:0044085;GO:0006793;GO:1901615;GO:0006144; protein homotetramerization;pyrimidine deoxyribonucleotide metabolic process;nucleotide biosynthetic process;deoxyribonucleoside monophosphate metabolic process;pteridine-containing compound metabolic process;small molecule catabolic process;small molecule biosynthetic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;pigment metabolic process;glycine biosynthetic process;glycine metabolic process;response to organic substance;water-soluble vitamin metabolic process;vitamin metabolic process;folic acid-containing compound metabolic process;monocarboxylic acid metabolic process;pyrimidine deoxyribonucleoside monophosphate biosynthetic process;pyrimidine deoxyribonucleoside monophosphate metabolic process;oxoacid metabolic process;organonitrogen compound metabolic process;serine family amino acid biosynthetic process;serine family amino acid catabolic process;heterocycle metabolic process;dicarboxylic acid metabolic process;cellular modified amino acid metabolic process;organonitrogen compound biosynthetic process;amino-acid betaine metabolic process;amino-acid betaine biosynthetic process;organic acid catabolic process;organic acid biosynthetic process;carbohydrate derivative biosynthetic process;aromatic compound biosynthetic process;small molecule metabolic process;cellular component assembly;cellular amino acid catabolic process;nitrogen compound metabolic process;carnitine biosynthetic process;tetrahydrofolate metabolic process;folic acid metabolic process;monocarboxylic acid biosynthetic process;organic substance biosynthetic process;organic substance catabolic process;cofactor metabolic process;L-serine metabolic process;ammonium ion metabolic process;tetrahydrofolate interconversion;cellular component organization;pyrimidine nucleotide biosynthetic process;macromolecular complex assembly;organic cyclic compound metabolic process;organophosphate metabolic process;heterocycle biosynthetic process;response to endogenous stimulus;deoxyribonucleoside monophosphate biosynthetic process;response to tetrahydrofolate;cellular response to tetrahydrofolate;cellular response to stimulus;deoxyribonucleotide biosynthetic process;deoxyribonucleotide metabolic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;organophosphate biosynthetic process;pigment biosynthetic process;cellular nitrogen compound biosynthetic process;carboxylic acid biosynthetic process;carboxylic acid catabolic process;response to stimulus;cellular response to nitrogen compound;cellular amide metabolic process;nucleotide metabolic process;nucleoside phosphate metabolic process;organic hydroxy compound biosynthetic process;organonitrogen compound catabolic process;protein complex biogenesis;coenzyme metabolic process;one-carbon metabolic process;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;pyrimidine nucleoside monophosphate metabolic process;cellular response to chemical stimulus;nucleoside monophosphate metabolic process;single-organism process;nucleobase-containing compound metabolic process;deoxyribose phosphate biosynthetic process;cellular amino acid biosynthetic process;alpha-amino acid metabolic process;alpha-amino acid catabolic process;cellular response to endogenous stimulus;cellular response to oxygen-containing compound;cellular process;cellular aromatic compound metabolic process;dTMP metabolic process;response to acid chemical;pyrimidine nucleoside monophosphate biosynthetic process;nucleobase-containing small molecule metabolic process;protein oligomerization;organic acid metabolic process;cellular response to organic cyclic compound;carbohydrate derivative metabolic process;response to organic cyclic compound;glycine biosynthetic process from serine;alpha-amino acid biosynthetic process;branched-chain amino acid metabolic process;response to nitrogen compound;branched-chain amino acid catabolic process;pyrimidine nucleotide metabolic process;nucleoside monophosphate biosynthetic process;macromolecular complex subunit organization;carboxylic acid metabolic process;cellular response to acid chemical;pyrimidine-containing compound biosynthetic process;carnitine metabolic process;nucleobase biosynthetic process;purine-containing compound metabolic process;purine-containing compound biosynthetic process;deoxyribose phosphate metabolic process;serine family amino acid metabolic process;pyrimidine-containing compound metabolic process;protein complex subunit organization;cellular response to organonitrogen compound;cellular amino acid metabolic process;protein homooligomerization;protein tetramerization;organic substance metabolic process;cellular response to organic substance;nucleoside phosphate biosynthetic process;dTMP biosynthetic process;protein complex assembly;pyrimidine deoxyribonucleotide biosynthetic process;L-serine catabolic process;purine nucleobase biosynthetic process;nucleobase metabolic process;biosynthetic process;single-organism cellular process;response to organonitrogen compound;response to chemical;catabolic process;response to oxygen-containing compound;primary metabolic process;2'-deoxyribonucleotide biosynthetic process;2'-deoxyribonucleotide metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process;organic hydroxy compound metabolic process;purine nucleobase metabolic process; 8;7;6;7;5;5;5;5;2;4;3;4;4;8;7;4;6;5;5;7;8;8;5;4;7;7;4;7;4;5;5;6;5;5;5;5;4;4;5;3;6;6;6;7;4;4;4;7;4;5;3;7;5;4;4;5;3;7;5;6;3;6;5;1;2;5;5;5;5;6;6;2;5;5;6;5;5;5;4;5;4;4;4;4;7;4;6;2;4;6;5;5;6;4;5;2;4;8;4;7;4;6;4;6;4;5;8;6;5;4;6;6;6;4;6;5;6;5;5;5;6;5;6;5;5;5;4;7;7;3;5;5;9;5;8;8;6;5;3;3;4;3;3;4;3;7;6;3;5;3;4;4;6; GO:0031982;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0043229;GO:0044444;GO:0005737;GO:0005634;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0005829;GO:0070062;GO:0043227;GO:0043226;GO:0005576;GO:1903561;GO:0005575; vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;intracellular organelle;cytoplasmic part;cytoplasm;nucleus;mitochondrion;cell part;cell;intracellular;cytosol;extracellular exosome;membrane-bounded organelle;organelle;extracellular region;extracellular vesicle;cellular_component; 4;3;4;3;2;3;4;4;5;5;2;2;3;5;4;3;2;2;3;1; GO:0030170;GO:0004793;GO:0016742;GO:0016740;GO:0016741;GO:0070905;GO:0003674;GO:0005488;GO:0043169;GO:0003824;GO:0016597;GO:0036094;GO:0031406;GO:0016832;GO:0046983;GO:0043167;GO:0042802;GO:0048037;GO:0008732;GO:0043177;GO:0016829;GO:0005515;GO:0097159;GO:0042803;GO:0016830;GO:1901363;GO:0004372;GO:0043168; pyridoxal phosphate binding;threonine aldolase activity;hydroxymethyl-, formyl- and related transferase activity;transferase activity;transferase activity, transferring one-carbon groups;serine binding;molecular_function;binding;cation binding;catalytic activity;amino acid binding;small molecule binding;carboxylic acid binding;aldehyde-lyase activity;protein dimerization activity;ion binding;identical protein binding;cofactor binding;L-allo-threonine aldolase activity;organic acid binding;lyase activity;protein binding;organic cyclic compound binding;protein homodimerization activity;carbon-carbon lyase activity;heterocyclic compound binding;glycine hydroxymethyltransferase activity;anion binding; 4;6;5;3;4;5;1;2;4;2;6;3;5;5;4;3;4;3;7;4;3;3;3;5;4;3;6;4; K00600 map00260;map00460;map00630;map00670;map00680;map01100;map01110;map01120;map01130;map01200;map01230; "Glycine, serine and threonine metabolism";Cyanoamino acid metabolism;Glyoxylate and dicarboxylate metabolism;One carbon pool by folate;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids; IPR001085;IPR019798;IPR015424;IPR015422;IPR015421; Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, pyridoxal phosphate binding site;Pyridoxal phosphate-dependent transferase;Pyridoxal phosphate-dependent transferase, subdomain 2;Pyridoxal phosphate-dependent transferase, major region, subdomain 1; nucleus Hs20070176 1005.0 E [E] Amino acid transport and metabolism; P13796 Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6 - [PLSL_HUMAN] 0.984 1.054 1.036 1.108 0.949 1.261 0.933586338 0.252672981 1.167544784 0.047430103 0.982922201 0.737675135 1.328767123 0.044156638 GO:0033157;GO:0008104;GO:0051049;GO:0032386;GO:0007165;GO:0051716;GO:0070727;GO:0033043;GO:0002366;GO:0048518;GO:0033036;GO:0043062;GO:0031100;GO:1902117;GO:0045184;GO:0046649;GO:0044700;GO:0016477;GO:0044707;GO:0048870;GO:0010638;GO:0002376;GO:0010737;GO:0030198;GO:0070489;GO:0022607;GO:0006928;GO:0045321;GO:0051223;GO:0002286;GO:0002285;GO:0006886;GO:0016043;GO:0065003;GO:0065007;GO:0071840;GO:0071593;GO:0034613;GO:0051130;GO:0070201;GO:0006810;GO:0098609;GO:0050794;GO:0001775;GO:0008150;GO:0006955;GO:0043254;GO:0051234;GO:0046907;GO:0050896;GO:0044763;GO:0002263;GO:0061572;GO:0070271;GO:0051128;GO:1903827;GO:0023052;GO:0035556;GO:0044699;GO:0032880;GO:0071803;GO:0071800;GO:0071801;GO:0031099;GO:0048513;GO:0022610;GO:0022617;GO:0032502;GO:0040011;GO:0032501;GO:0009987;GO:0031334;GO:0070486;GO:0007010;GO:0032879;GO:0051674;GO:0048731;GO:0016337;GO:0060341;GO:0043933;GO:0042110;GO:0007275;GO:0071822;GO:0050789;GO:1902115;GO:0071702;GO:0030029;GO:0051017;GO:0006461;GO:0044767;GO:0007159;GO:0051649;GO:0007155;GO:0007154;GO:0070925;GO:0051179;GO:0051641;GO:0006996;GO:0007015;GO:0098602;GO:0048856;GO:0044087;GO:1902589;GO:0044085;GO:0030036;GO:0002252;GO:0015031;GO:0048522;GO:0022411;GO:0044089; regulation of intracellular protein transport;protein localization;regulation of transport;regulation of intracellular transport;signal transduction;cellular response to stimulus;cellular macromolecule localization;regulation of organelle organization;leukocyte activation involved in immune response;positive regulation of biological process;macromolecule localization;extracellular structure organization;organ regeneration;positive regulation of organelle assembly;establishment of protein localization;lymphocyte activation;single organism signaling;cell migration;single-multicellular organism process;cell motility;positive regulation of organelle organization;immune system process;protein kinase A signaling;extracellular matrix organization;T cell aggregation;cellular component assembly;movement of cell or subcellular component;leukocyte activation;regulation of protein transport;T cell activation involved in immune response;lymphocyte activation involved in immune response;intracellular protein transport;cellular component organization;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;lymphocyte aggregation;cellular protein localization;positive regulation of cellular component organization;regulation of establishment of protein localization;transport;cell-cell adhesion;regulation of cellular process;cell activation;biological_process;immune response;regulation of protein complex assembly;establishment of localization;intracellular transport;response to stimulus;single-organism cellular process;cell activation involved in immune response;actin filament bundle organization;protein complex biogenesis;regulation of cellular component organization;regulation of cellular protein localization;signaling;intracellular signal transduction;single-organism process;regulation of protein localization;positive regulation of podosome assembly;podosome assembly;regulation of podosome assembly;regeneration;animal organ development;biological adhesion;extracellular matrix disassembly;developmental process;locomotion;multicellular organismal process;cellular process;positive regulation of protein complex assembly;leukocyte aggregation;cytoskeleton organization;regulation of localization;localization of cell;system development;single organismal cell-cell adhesion;regulation of cellular localization;macromolecular complex subunit organization;T cell activation;multicellular organism development;protein complex subunit organization;regulation of biological process;regulation of organelle assembly;organic substance transport;actin filament-based process;actin filament bundle assembly;protein complex assembly;single-organism developmental process;leukocyte cell-cell adhesion;establishment of localization in cell;cell adhesion;cell communication;organelle assembly;localization;cellular localization;organelle organization;actin filament organization;single organism cell adhesion;anatomical structure development;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;actin cytoskeleton organization;immune effector process;protein transport;positive regulation of cellular process;cellular component disassembly;positive regulation of cellular component biogenesis; 6;4;4;5;4;3;4;5;4;2;3;4;5;4;4;4;3;4;3;3;5;2;6;5;4;4;4;3;5;4;4;6;3;5;2;2;7;5;4;5;4;4;3;4;1;3;4;3;5;2;3;4;7;4;4;5;2;5;2;4;5;6;5;4;4;2;5;2;2;2;2;4;6;5;3;3;4;4;4;4;5;4;5;2;4;5;4;5;5;3;5;4;3;4;5;2;3;4;6;3;3;3;4;3;5;3;5;3;4;3; GO:0032432;GO:0099512;GO:0099513;GO:0030054;GO:0030055;GO:0031982;GO:0042995;GO:0043234;GO:0043230;GO:0043232;GO:0005829;GO:0098858;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0098590;GO:0030175;GO:0043229;GO:0043228;GO:0005924;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0031256;GO:0070161;GO:0031253;GO:0031252;GO:0002102;GO:0044446;GO:0044444;GO:0005884;GO:0005886;GO:0005737;GO:1903561;GO:0005912;GO:0032587;GO:0001891;GO:0044459;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0071944;GO:0016020;GO:0001726;GO:0005925;GO:0005615;GO:0098805;GO:0070062;GO:0005576;GO:0098589;GO:0032991;GO:0005575; actin filament bundle;supramolecular fiber;polymeric cytoskeletal fiber;cell junction;cell-substrate junction;vesicle;cell projection;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;actin-based cell projection;intracellular part;membrane part;extracellular region part;organelle part;plasma membrane region;filopodium;intracellular organelle;non-membrane-bounded organelle;cell-substrate adherens junction;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;leading edge membrane;anchoring junction;cell projection membrane;cell leading edge;podosome;intracellular organelle part;cytoplasmic part;actin filament;plasma membrane;cytoplasm;extracellular vesicle;adherens junction;ruffle membrane;phagocytic cup;plasma membrane part;cell projection part;cell part;cell;intracellular;actin cytoskeleton;cell periphery;membrane;ruffle;focal adhesion;extracellular space;whole membrane;extracellular exosome;extracellular region;membrane region;macromolecular complex;cellular_component; 5;2;3;2;3;4;3;3;3;4;5;4;3;2;2;2;4;5;3;3;4;3;2;5;4;4;3;4;3;4;3;4;4;3;4;3;4;5;4;3;3;2;2;3;6;3;2;4;5;3;3;4;2;3;2;1; GO:0003779;GO:0044877;GO:0003674;GO:0005488;GO:0043169;GO:0008092;GO:0019899;GO:0043167;GO:0005509;GO:0032403;GO:0046872;GO:0051020;GO:0005515;GO:0051015; actin binding;macromolecular complex binding;molecular_function;binding;cation binding;cytoskeletal protein binding;enzyme binding;ion binding;calcium ion binding;protein complex binding;metal ion binding;GTPase binding;protein binding;actin filament binding; 5;3;1;2;4;4;4;3;6;4;5;5;3;5; K17276 IPR001715;IPR002048;IPR018247;IPR011992;IPR001589; Calponin homology domain;EF-hand domain;EF-Hand 1, calcium-binding site;EF-hand domain pair;Actinin-type actin-binding domain, conserved site; cytosol Hs4504965 1290.0 Z [Z] Cytoskeleton; P78563 Double-stranded RNA-specific editase 1 OS=Homo sapiens OX=9606 GN=ADARB1 PE=1 SV=1 - [RED1_HUMAN] 1.22 0.762 1.281 1.038 0.756 0.912 1.601049869 0.00202265 1.373015873 0.001360363 1.681102362 0.010106039 1.206349206 0.122790537 GO:0051348;GO:0019220;GO:0080090;GO:0019222;GO:0009451;GO:1901360;GO:0010605;GO:0009615;GO:0044419;GO:0019058;GO:0044092;GO:0048518;GO:0048519;GO:0046483;GO:0006382;GO:0042127;GO:0006397;GO:0060255;GO:0045859;GO:0051707;GO:0051704;GO:0042325;GO:0042326;GO:0009607;GO:0048870;GO:0019538;GO:0002376;GO:0016553;GO:0033673;GO:0009892;GO:0043900;GO:0006928;GO:0051674;GO:0006807;GO:0050789;GO:0044267;GO:0044260;GO:0043549;GO:0065007;GO:0007049;GO:0065009;GO:0016477;GO:0050792;GO:0050790;GO:0050794;GO:0006952;GO:0043903;GO:0043412;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0006955;GO:0016070;GO:0043902;GO:0051607;GO:0050896;GO:0006950;GO:0051338;GO:2000145;GO:2000146;GO:0043207;GO:0016310;GO:0034641;GO:0043086;GO:0044699;GO:0006139;GO:0051248;GO:1903900;GO:1903902;GO:0016556;GO:0010563;GO:0051246;GO:0045070;GO:0008285;GO:0016071;GO:0019079;GO:0031399;GO:0006725;GO:0051271;GO:0051270;GO:0098542;GO:0032879;GO:0032269;GO:0032268;GO:0045069;GO:0043170;GO:0009987;GO:0031400;GO:0044387;GO:0031324;GO:0031323;GO:0090304;GO:0008283;GO:0071704;GO:0010467;GO:0009605;GO:0030336;GO:0006468;GO:0006469;GO:0045936;GO:0045087;GO:0002252;GO:0030334;GO:0051174;GO:0044764;GO:0044763;GO:0044403;GO:0051179;GO:0040011;GO:0044238;GO:0040013;GO:0040012;GO:0051726;GO:0044237;GO:0006796;GO:0006396;GO:0016032;GO:0006793;GO:0048524;GO:0001933;GO:0001932;GO:0048523;GO:0048522; negative regulation of transferase activity;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;RNA modification;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;response to virus;interspecies interaction between organisms;viral life cycle;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;heterocycle metabolic process;adenosine to inosine editing;regulation of cell proliferation;mRNA processing;regulation of macromolecule metabolic process;regulation of protein kinase activity;response to other organism;multi-organism process;regulation of phosphorylation;negative regulation of phosphorylation;response to biotic stimulus;cell motility;protein metabolic process;immune system process;base conversion or substitution editing;negative regulation of kinase activity;negative regulation of metabolic process;regulation of multi-organism process;movement of cell or subcellular component;localization of cell;nitrogen compound metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;biological regulation;cell cycle;regulation of molecular function;cell migration;regulation of viral process;regulation of catalytic activity;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;macromolecule modification;protein modification process;biological_process;cellular protein modification process;metabolic process;immune response;RNA metabolic process;positive regulation of multi-organism process;defense response to virus;response to stimulus;response to stress;regulation of transferase activity;regulation of cell motility;negative regulation of cell motility;response to external biotic stimulus;phosphorylation;cellular nitrogen compound metabolic process;negative regulation of catalytic activity;single-organism process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;regulation of viral life cycle;positive regulation of viral life cycle;mRNA modification;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of viral genome replication;negative regulation of cell proliferation;mRNA metabolic process;viral genome replication;regulation of protein modification process;cellular aromatic compound metabolic process;negative regulation of cellular component movement;regulation of cellular component movement;defense response to other organism;regulation of localization;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of viral genome replication;macromolecule metabolic process;cellular process;negative regulation of protein modification process;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell proliferation;organic substance metabolic process;gene expression;response to external stimulus;negative regulation of cell migration;protein phosphorylation;negative regulation of protein kinase activity;negative regulation of phosphate metabolic process;innate immune response;immune effector process;regulation of cell migration;regulation of phosphorus metabolic process;multi-organism cellular process;single-organism cellular process;symbiosis, encompassing mutualism through parasitism;localization;locomotion;primary metabolic process;negative regulation of locomotion;regulation of locomotion;regulation of cell cycle;cellular metabolic process;phosphate-containing compound metabolic process;RNA processing;viral process;phosphorus metabolic process;positive regulation of viral process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;6;4;3;6;4;4;4;3;5;4;2;2;4;8;4;7;4;7;3;2;7;7;3;3;4;2;7;7;3;3;4;3;3;2;5;4;6;2;4;3;4;4;4;3;4;4;5;5;1;6;2;3;5;3;4;2;3;5;4;4;4;6;4;5;2;4;5;5;5;7;5;5;6;4;6;5;6;4;4;4;4;3;5;5;6;4;2;6;9;4;4;5;3;3;5;3;5;7;8;6;4;3;5;5;3;3;4;2;2;3;3;3;4;3;5;6;4;4;4;7;7;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0043228;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleolus;nucleus;cell part;cell;non-membrane-bounded organelle;organelle;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;2;3;3;3;5;3;4;5;5;2;2;3;2;1;4; GO:1901363;GO:0016810;GO:0016814;GO:0005488;GO:0003676;GO:0019239;GO:0003725;GO:0004000;GO:0016787;GO:0043169;GO:0003824;GO:0097159;GO:0046872;GO:0043167;GO:0044822;GO:0003726;GO:0003723;GO:0003674;GO:0003729; heterocyclic compound binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;binding;nucleic acid binding;deaminase activity;double-stranded RNA binding;adenosine deaminase activity;hydrolase activity;cation binding;catalytic activity;organic cyclic compound binding;metal ion binding;ion binding;poly(A) RNA binding;double-stranded RNA adenosine deaminase activity;RNA binding;molecular_function;mRNA binding; 3;4;5;2;4;3;6;4;3;4;2;3;5;3;6;5;5;1;7; K13194 IPR014720;IPR002466;IPR008996; Double-stranded RNA-binding domain;Adenosine deaminase/editase;Cytokine IL1/FGF; nucleus Hs7669477 1529.0 A [A] RNA processing and modification; Q5H9U9 Probable ATP-dependent RNA helicase DDX60-like OS=Homo sapiens OX=9606 GN=DDX60L PE=2 SV=2 - [DDX6L_HUMAN] 0.925 1.135 0.785 1.041 1.223 1.34 0.814977974 0.059859812 0.851185609 0.092509412 0.691629956 0.002808973 1.095666394 0.823753912 GO:0035639;GO:0003674;GO:0005488;GO:0003676;GO:0043167;GO:1901363;GO:0001883;GO:0001882;GO:0043168;GO:0000166;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0017111;GO:0004386;GO:0036094;GO:0003824;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032559;GO:0003723;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;nucleic acid binding;ion binding;heterocyclic compound binding;purine nucleoside binding;nucleoside binding;anion binding;nucleotide binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;nucleoside-triphosphatase activity;helicase activity;small molecule binding;catalytic activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;adenyl ribonucleotide binding;RNA binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;4;3;3;5;4;4;4;4;5;5;6;3;7;8;3;2;5;6;3;3;4;6;6;5;5;6;4; K20103 IPR011545;IPR001650;IPR027417;IPR014001; DEAD/DEAH box helicase domain;Helicase, C-terminal;P-loop containing nucleoside triphosphate hydrolase;Helicase superfamily 1/2, ATP-binding domain; cytosol Hs18556835 1165.0 R [R] General function prediction only; P22352 Glutathione peroxidase 3 OS=Homo sapiens OX=9606 GN=GPX3 PE=1 SV=2 - [GPX3_HUMAN] 0.943 1.169 0.856 0.968 1.175 1.147 0.80667237 1.01E-07 0.823829787 0.000661119 0.732249786 0.001054155 0.976170213 0.592033021 GO:0022607;GO:0042743;GO:0070271;GO:0043933;GO:0009636;GO:0000302;GO:0044248;GO:0042744;GO:0016043;GO:0098754;GO:0071840;GO:0044712;GO:0098869;GO:0044710;GO:0071822;GO:0006982;GO:0051289;GO:0051260;GO:0051262;GO:0010033;GO:0065003;GO:0044085;GO:0044699;GO:1901700;GO:0009987;GO:0033194;GO:0006461;GO:0072593;GO:0006950;GO:0008150;GO:0008152;GO:0042221;GO:0009056;GO:0006979;GO:0051259;GO:0050896;GO:1990748;GO:0044237;GO:0044763; cellular component assembly;hydrogen peroxide metabolic process;protein complex biogenesis;macromolecular complex subunit organization;response to toxic substance;response to reactive oxygen species;cellular catabolic process;hydrogen peroxide catabolic process;cellular component organization;detoxification;cellular component organization or biogenesis;single-organism catabolic process;cellular oxidant detoxification;single-organism metabolic process;protein complex subunit organization;response to lipid hydroperoxide;protein homotetramerization;protein homooligomerization;protein tetramerization;response to organic substance;macromolecular complex assembly;cellular component biogenesis;single-organism process;response to oxygen-containing compound;cellular process;response to hydroperoxide;protein complex assembly;reactive oxygen species metabolic process;response to stress;biological_process;metabolic process;response to chemical;catabolic process;response to oxidative stress;protein oligomerization;response to stimulus;cellular detoxification;cellular metabolic process;single-organism cellular process; 4;5;4;4;4;5;4;4;3;2;2;4;4;3;5;5;8;7;7;4;5;3;2;4;2;5;5;4;3;1;2;3;3;4;6;2;3;3;3; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:1903561;GO:0031982;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;extracellular vesicle;vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;4;3;1;2;2; GO:0003674;GO:0016491;GO:0016684;GO:0016209;GO:0008134;GO:0003824;GO:0008430;GO:0004601;GO:0005515;GO:0004602;GO:0005488; molecular_function;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;antioxidant activity;transcription factor binding;catalytic activity;selenium binding;peroxidase activity;protein binding;glutathione peroxidase activity;binding; 1;3;4;2;4;2;3;3;3;4;2; K00432 map00480;map00590;map04918; Glutathione metabolism;Arachidonic acid metabolism;Thyroid hormone synthesis; IPR029759;IPR000889;IPR012336;IPR029760; Glutathione peroxidase active site;Glutathione peroxidase;Thioredoxin-like fold;Glutathione peroxidase conserved site; extracellular Hs6006001 470.0 O [O] Posttranslational modification, protein turnover, chaperones; Q6ZMY6 WD repeat-containing protein 88 OS=Homo sapiens OX=9606 GN=WDR88 PE=2 SV=2 - [WDR88_HUMAN] 1.126 1.26 0.573 1.493 1.052 0.555 0.893650794 nan 1.419201521 nan 0.454761905 nan 0.52756654 nan IPR002372;IPR020472;IPR017986;IPR001680;IPR019775;IPR018391;IPR011047; Pyrrolo-quinoline quinone repeat;G-protein beta WD-40 repeat;WD40-repeat-containing domain;WD40 repeat;WD40 repeat, conserved site;Pyrrolo-quinoline quinone beta-propeller repeat;Quinoprotein alcohol dehydrogenase-like superfamily; cytosol, nucleus Hs22052079 855.0 R [R] General function prediction only; Q92636 Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2 - [FAN_HUMAN] 1.176 1.016 0.93 1.183 0.87 1.187 1.157480315 nan 1.359770115 nan 0.915354331 nan 1.364367816 nan GO:0019221;GO:0019222;GO:0007165;GO:0007166;GO:0071840;GO:0080090;GO:0051716;GO:0044711;GO:0071310;GO:0045834;GO:0048518;GO:0006665;GO:0060255;GO:0010033;GO:0044700;GO:1901564;GO:1901566;GO:0006672;GO:0009893;GO:0009891;GO:1905038;GO:0006807;GO:0043170;GO:0042981;GO:0050789;GO:0034097;GO:1901576;GO:0071356;GO:0065007;GO:0030148;GO:0006629;GO:0009889;GO:0044710;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0044271;GO:0071345;GO:0050896;GO:0010556;GO:2000304;GO:2000303;GO:0034250;GO:0033209;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0046467;GO:0006643;GO:0009987;GO:0034248;GO:0046889;GO:0044255;GO:0043604;GO:0043603;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0046890;GO:0010942;GO:0008219;GO:0010941;GO:0043065;GO:0071704;GO:0043067;GO:0043068;GO:0019216;GO:0034612;GO:0006915;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0007154;GO:0008610;GO:0044238;GO:0090153;GO:0090154;GO:0044237;GO:0044087;GO:0044085;GO:0046513;GO:0048522; cytokine-mediated signaling pathway;regulation of metabolic process;signal transduction;cell surface receptor signaling pathway;cellular component organization or biogenesis;regulation of primary metabolic process;cellular response to stimulus;single-organism biosynthetic process;cellular response to organic substance;positive regulation of lipid metabolic process;positive regulation of biological process;sphingolipid metabolic process;regulation of macromolecule metabolic process;response to organic substance;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;ceramide metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;regulation of membrane lipid metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of apoptotic process;regulation of biological process;response to cytokine;organic substance biosynthetic process;cellular response to tumor necrosis factor;biological regulation;sphingolipid biosynthetic process;lipid metabolic process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;programmed cell death;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;regulation of macromolecule biosynthetic process;positive regulation of ceramide biosynthetic process;regulation of ceramide biosynthetic process;positive regulation of cellular amide metabolic process;tumor necrosis factor-mediated signaling pathway;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;membrane lipid biosynthetic process;membrane lipid metabolic process;cellular process;regulation of cellular amide metabolic process;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;amide biosynthetic process;cellular amide metabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of lipid biosynthetic process;positive regulation of cell death;cell death;regulation of cell death;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;positive regulation of programmed cell death;regulation of lipid metabolic process;response to tumor necrosis factor;apoptotic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;lipid biosynthetic process;primary metabolic process;regulation of sphingolipid biosynthetic process;positive regulation of sphingolipid biosynthetic process;cellular metabolic process;regulation of cellular component biogenesis;cellular component biogenesis;ceramide biosynthetic process;positive regulation of cellular process; 6;3;4;5;2;4;3;4;5;4;2;5;4;4;3;4;5;6;3;4;5;3;4;6;2;5;4;7;2;6;4;4;3;3;5;1;2;5;6;2;5;6;5;5;7;4;4;2;4;3;2;5;5;2;5;5;4;6;5;5;5;4;4;5;4;4;4;6;3;5;5;5;6;6;3;5;3;4;4;4;5;3;4;5;3;3;3;7;3; GO:0016020;GO:0005829;GO:0044424;GO:0044425;GO:0012505;GO:0044444;GO:0019898;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575; membrane;cytosol;intracellular part;membrane part;endomembrane system;cytoplasmic part;extrinsic component of membrane;cytoplasm;cell part;cell;intracellular;cellular_component; 2;5;3;2;3;4;3;4;2;2;3;1; GO:0098772;GO:0003674;GO:0005488;GO:0030234;GO:0043168;GO:0005543;GO:0043167;GO:0016230;GO:0008289;GO:0008047;GO:0004871;GO:0060229;GO:0005057;GO:0016004; molecular function regulator;molecular_function;binding;enzyme regulator activity;anion binding;phospholipid binding;ion binding;sphingomyelin phosphodiesterase activator activity;lipid binding;enzyme activator activity;signal transducer activity;lipase activator activity;receptor signaling protein activity;phospholipase activator activity; 2;1;2;3;4;4;3;7;3;4;2;5;3;6; K18953 map04071; Sphingolipid signaling pathway; IPR017986;IPR001680;IPR004182;IPR015943;IPR011993;IPR023362;IPR000409; WD40-repeat-containing domain;WD40 repeat;GRAM domain;WD40/YVTN repeat-like-containing domain;PH domain-like;PH-BEACH domain;BEACH domain; cytosol Hs4505465_2 1319.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q8TEU7 Rap guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=RAPGEF6 PE=1 SV=2 - [RPGF6_HUMAN] 0.616 0.906 1.394 0.831 1.289 1.081 0.6799117 0.209466098 0.644685803 0.013269308 1.538631347 0.06158973 0.8386346 0.771767795 GO:0008104;GO:0007009;GO:0007165;GO:0071840;GO:0051716;GO:0070727;GO:0010256;GO:0044093;GO:0033036;GO:0072657;GO:0072659;GO:0044700;GO:0061024;GO:0022607;GO:0035556;GO:0043547;GO:0051345;GO:0016043;GO:0065007;GO:0044699;GO:0065009;GO:0050790;GO:0008150;GO:0050794;GO:0051336;GO:0050896;GO:0044802;GO:0023052;GO:1990778;GO:0043087;GO:0043085;GO:0009987;GO:0030030;GO:0030031;GO:0030033;GO:0050789;GO:0034613;GO:0032528;GO:0044763;GO:0007154;GO:0007265;GO:0007264;GO:0051179;GO:1902578;GO:0051641;GO:0044085;GO:1902580; protein localization;plasma membrane organization;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;cellular macromolecule localization;endomembrane system organization;positive regulation of molecular function;macromolecule localization;protein localization to membrane;protein localization to plasma membrane;single organism signaling;membrane organization;cellular component assembly;intracellular signal transduction;positive regulation of GTPase activity;positive regulation of hydrolase activity;cellular component organization;biological regulation;single-organism process;regulation of molecular function;regulation of catalytic activity;biological_process;regulation of cellular process;regulation of hydrolase activity;response to stimulus;single-organism membrane organization;signaling;protein localization to cell periphery;regulation of GTPase activity;positive regulation of catalytic activity;cellular process;cell projection organization;cell projection assembly;microvillus assembly;regulation of biological process;cellular protein localization;microvillus organization;single-organism cellular process;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;localization;single-organism localization;cellular localization;cellular component biogenesis;single-organism cellular localization; 4;5;4;2;3;4;4;4;3;5;6;3;4;4;5;7;6;3;2;2;3;4;1;3;5;2;4;2;6;6;5;2;4;5;6;2;5;5;3;4;7;6;2;3;3;3;4; GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0098589;GO:0043231;GO:0005829;GO:0044424;GO:0044425;GO:0098590;GO:0043227;GO:0043226;GO:0097708;GO:0044444;GO:0005737;GO:0045177;GO:0031410;GO:0044459;GO:0016324;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0030139;GO:0071944;GO:0098805;GO:0005886;GO:0005575; vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;membrane region;intracellular membrane-bounded organelle;cytosol;intracellular part;membrane part;plasma membrane region;membrane-bounded organelle;organelle;intracellular vesicle;cytoplasmic part;cytoplasm;apical part of cell;cytoplasmic vesicle;plasma membrane part;apical plasma membrane;cell part;intracellular organelle;cell;intracellular;endocytic vesicle;cell periphery;whole membrane;plasma membrane;cellular_component; 4;5;2;5;3;4;5;3;2;4;3;2;4;4;4;3;5;3;4;2;3;2;3;6;3;3;3;1; GO:0031267;GO:0098772;GO:0030742;GO:0005085;GO:0051020;GO:0003674;GO:0005488;GO:0043168;GO:0017016;GO:0005543;GO:0019899;GO:0043167;GO:0070300;GO:0008289;GO:0005515; small GTPase binding;molecular function regulator;GTP-dependent protein binding;guanyl-nucleotide exchange factor activity;GTPase binding;molecular_function;binding;anion binding;Ras GTPase binding;phospholipid binding;enzyme binding;ion binding;phosphatidic acid binding;lipid binding;protein binding; 6;2;4;3;5;1;2;4;7;4;4;3;5;3;3; K08020 map04015; Rap1 signaling pathway; IPR001478;IPR023578;IPR014710;IPR000159;IPR000651;IPR018490;IPR000595;IPR001895; PDZ domain;Ras guanine nucleotide exchange factor domain;RmlC-like jelly roll fold;Ras-associating (RA) domain;Ras-like guanine nucleotide exchange factor, N-terminal;Cyclic nucleotide-binding-like;Cyclic nucleotide-binding domain;Ras guanine-nucleotide exchange factors catalytic domain; nucleus Hs7706513 2348.0 T [T] Signal transduction mechanisms; O60682 Musculin OS=Homo sapiens OX=9606 GN=MSC PE=1 SV=2 - [MUSC_HUMAN] 0.864 1.036 0.873 1.398 1.282 0.496 0.833976834 nan 1.090483619 nan 0.842664093 nan 0.386895476 nan GO:1901362;GO:1901360;GO:0007517;GO:0007519;GO:0048513;GO:0060541;GO:0006366;GO:0046483;GO:0044707;GO:0019438;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0018130;GO:0006139;GO:0009888;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0061061;GO:0044699;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0043170;GO:0048731;GO:0060021;GO:0090304;GO:0014706;GO:0014707;GO:0007275;GO:0071704;GO:0010467;GO:0044767;GO:0009058;GO:0009059;GO:0044238;GO:0048856;GO:0044237;GO:0060537;GO:0060538;GO:0060539; organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;muscle organ development;skeletal muscle tissue development;animal organ development;respiratory system development;transcription from RNA polymerase II promoter;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;tissue development;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;muscle structure development;single-organism process;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;macromolecule metabolic process;system development;palate development;nucleic acid metabolic process;striated muscle tissue development;branchiomeric skeletal muscle development;multicellular organism development;organic substance metabolic process;gene expression;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;primary metabolic process;anatomical structure development;cellular metabolic process;muscle tissue development;skeletal muscle organ development;diaphragm development; 5;4;5;7;4;5;7;4;3;5;3;7;4;4;5;4;4;1;2;5;5;5;6;6;4;4;5;4;2;2;2;2;4;4;4;4;5;6;6;4;3;5;3;3;5;3;3;3;5;6;6; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;3;2;5;3;5;2;2;1;4; GO:0001071;GO:1901363;GO:0003714;GO:0003712;GO:0001067;GO:0044212;GO:0000980;GO:0001012;GO:0001158;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0000988;GO:0000981;GO:0097159;GO:0000976;GO:0000975;GO:0043565;GO:1990837;GO:0003690;GO:0035326;GO:0001227;GO:0000977;GO:0001206;GO:0003700;GO:0003705; nucleic acid binding transcription factor activity;heterocyclic compound binding;transcription corepressor activity;transcription cofactor activity;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II distal enhancer sequence-specific DNA binding;RNA polymerase II regulatory region DNA binding;enhancer sequence-specific DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;enhancer binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;transcription factor activity, sequence-specific DNA binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; 2;3;5;4;5;7;10;8;9;1;2;4;5;3;2;4;3;8;6;6;7;6;8;5;9;6;3;5; K09072 IPR011598; Myc-type, basic helix-loop-helix (bHLH) domain; nucleus Hs18571414 416.0 K [K] Transcription; Q7Z591 AT-hook-containing transcription factor OS=Homo sapiens OX=9606 GN=AKNA PE=1 SV=2 - [AKNA_HUMAN] 0.743 1.15 1.209 0.705 1.209 0.801 0.646086957 0.221859222 0.583126551 0.166833763 1.051304348 0.290904676 0.662531017 0.193606499 GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010604;GO:0048518;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0010628;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0006807;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of gene expression;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;2;4;6;4;5;3;4;5;7;4;4;2;7;5;4;3;1;2;5;5;5;6;5;5;6;6;4;4;5;4;7;2;4;7;6;5;5;4;6;3;7;5;5;4;4;5;6;2;3;5;7;5;5;5;3;5;4;4;3;3;3; GO:0016020;GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005575; membrane;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleus;cell part;cell;cellular_component; 2;4;3;3;3;3;2;5;2;2;1; GO:0001077;GO:0001071;GO:1901363;GO:0001067;GO:0044212;GO:0001012;GO:0001159;GO:0001228;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000987;GO:0000982;GO:0000981;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:0000978;GO:1990837;GO:0003690;GO:0000977;GO:0003700; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter proximal region sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 6;2;3;5;7;8;8;5;1;2;4;5;9;5;4;6;3;8;6;10;7;6;9;3; K21404 IPR022150; Transcription factor, AT-hook-containing; nucleus Q53H12 Acylglycerol kinase, mitochondrial OS=Homo sapiens OX=9606 GN=AGK PE=1 SV=2 - [AGK_HUMAN] 0.887 0.92 1.741 0.893 0.774 0.333 0.964130435 nan 1.15374677 nan 1.892391304 nan 0.430232558 nan GO:0044281;GO:0044710;GO:0044711;GO:0006665;GO:0046486;GO:1901564;GO:1901566;GO:0019432;GO:0071616;GO:0006672;GO:0006629;GO:1901576;GO:0051186;GO:0051188;GO:0030148;GO:0035383;GO:0035384;GO:0008150;GO:0008152;GO:0044271;GO:0044272;GO:0044763;GO:0006637;GO:0006732;GO:0006639;GO:0006638;GO:0044249;GO:0034641;GO:0035338;GO:0035336;GO:0035337;GO:0044699;GO:0046467;GO:0046463;GO:0046460;GO:0006643;GO:0006641;GO:0009987;GO:0044255;GO:0043604;GO:0043603;GO:0006807;GO:0009108;GO:0045017;GO:0071704;GO:0009058;GO:0046949;GO:0008610;GO:0044238;GO:0044237;GO:0006790;GO:0006793;GO:0046513; small molecule metabolic process;single-organism metabolic process;single-organism biosynthetic process;sphingolipid metabolic process;glycerolipid metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;triglyceride biosynthetic process;acyl-CoA biosynthetic process;ceramide metabolic process;lipid metabolic process;organic substance biosynthetic process;cofactor metabolic process;cofactor biosynthetic process;sphingolipid biosynthetic process;thioester metabolic process;thioester biosynthetic process;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;sulfur compound biosynthetic process;single-organism cellular process;acyl-CoA metabolic process;coenzyme metabolic process;acylglycerol metabolic process;neutral lipid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;long-chain fatty-acyl-CoA biosynthetic process;long-chain fatty-acyl-CoA metabolic process;fatty-acyl-CoA metabolic process;single-organism process;membrane lipid biosynthetic process;acylglycerol biosynthetic process;neutral lipid biosynthetic process;membrane lipid metabolic process;triglyceride metabolic process;cellular process;cellular lipid metabolic process;amide biosynthetic process;cellular amide metabolic process;nitrogen compound metabolic process;coenzyme biosynthetic process;glycerolipid biosynthetic process;organic substance metabolic process;biosynthetic process;fatty-acyl-CoA biosynthetic process;lipid biosynthetic process;primary metabolic process;cellular metabolic process;sulfur compound metabolic process;phosphorus metabolic process;ceramide biosynthetic process; 4;3;4;5;5;4;5;7;6;6;4;4;4;5;6;4;5;1;2;5;5;3;5;5;6;5;4;4;8;7;6;2;5;6;5;5;7;2;4;6;5;3;6;5;3;3;7;5;3;3;4;4;7; GO:0031975;GO:0016020;GO:0031968;GO:0098588;GO:0031967;GO:0031966;GO:0043231;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044429;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005739;GO:0044464;GO:0019867;GO:0005623;GO:0005622;GO:0005740;GO:0005741;GO:0098805;GO:0005575; envelope;membrane;organelle outer membrane;bounding membrane of organelle;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;mitochondrial part;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;mitochondrion;cell part;outer membrane;cell;intracellular;mitochondrial envelope;mitochondrial outer membrane;whole membrane;cellular_component; 3;2;4;4;4;4;4;3;2;3;3;2;4;3;4;4;3;5;2;3;2;3;5;5;3;1; GO:1901363;GO:0000166;GO:0035639;GO:0016740;GO:0097367;GO:0047620;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0004143;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0043167;GO:0030554;GO:0097159;GO:0001883;GO:0001882;GO:0001727;GO:0001729;GO:0036094; heterocyclic compound binding;nucleotide binding;purine ribonucleoside triphosphate binding;transferase activity;carbohydrate derivative binding;acylglycerol kinase activity;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;diacylglycerol kinase activity;ATP binding;anion binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;lipid kinase activity;ceramide kinase activity;small molecule binding; 3;4;5;3;3;6;1;2;4;5;5;6;6;4;5;2;5;4;6;5;6;4;3;6;3;5;4;6;7;3; K09881 map00561;map01100; Glycerolipid metabolism;Metabolic pathways; IPR017438;IPR001206;IPR016064; Inorganic polyphosphate/ATP-NAD kinase, domain 1;Diacylglycerol kinase, catalytic domain;NAD kinase/diacylglycerol kinase-like domain; cytosol Hs8922701 877.0 IT [I] Lipid transport and metabolism;[T] Signal transduction mechanisms; Q9BYT9 Anoctamin-3 OS=Homo sapiens OX=9606 GN=ANO3 PE=1 SV=2 - [ANO3_HUMAN] 0.846 1.123 1.03 0.988 1.081 1.04 0.75333927 0.762255194 0.913968548 0.600422643 0.917186109 0.348231352 0.962072155 0.661308779 GO:0017121;GO:0061024;GO:0007009;GO:0009612;GO:0044802;GO:0044699;GO:0016048;GO:0061591;GO:0061590;GO:0010256;GO:0016043;GO:0051179;GO:0065007;GO:0071840;GO:0065008;GO:0009581;GO:0009582;GO:0006810;GO:0006811;GO:0009987;GO:0034220;GO:0044765;GO:0008150;GO:0009266;GO:0051234;GO:0055085;GO:1902578;GO:0009628;GO:0061588;GO:0051606;GO:0009605;GO:0050896;GO:0097035;GO:0050982;GO:0044763; phospholipid scrambling;membrane organization;plasma membrane organization;response to mechanical stimulus;single-organism membrane organization;single-organism process;detection of temperature stimulus;calcium activated galactosylceramide scrambling;calcium activated phosphatidylcholine scrambling;endomembrane system organization;cellular component organization;localization;biological regulation;cellular component organization or biogenesis;regulation of biological quality;detection of external stimulus;detection of abiotic stimulus;transport;ion transport;cellular process;ion transmembrane transport;single-organism transport;biological_process;response to temperature stimulus;establishment of localization;transmembrane transport;single-organism localization;response to abiotic stimulus;calcium activated phospholipid scrambling;detection of stimulus;response to external stimulus;response to stimulus;regulation of membrane lipid distribution;detection of mechanical stimulus;single-organism cellular process; 5;4;5;4;4;2;5;7;7;4;3;2;2;2;3;4;4;4;5;2;5;4;1;4;3;4;3;3;6;3;3;2;4;5;3; GO:0005886;GO:0071944;GO:0016021;GO:0016020;GO:0044425;GO:0005623;GO:0044464;GO:0031224;GO:0005575; plasma membrane;cell periphery;integral component of membrane;membrane;membrane part;cell;cell part;intrinsic component of membrane;cellular_component; 3;3;4;2;2;2;2;3;1; GO:0017128;GO:0003674;GO:0005548;GO:0005319;GO:0005215;GO:0022892; phospholipid scramblase activity;molecular_function;phospholipid transporter activity;lipid transporter activity;transporter activity;substrate-specific transporter activity; 6;1;5;4;2;3; K19498 IPR031292;IPR007632;IPR032394; Anoctamin-3;Anoctamin;Anoctamin, dimerisation domain; plasma membrane Hs13899227 2046.0 S [S] Function unknown; Q9H4Z2 Zinc finger protein 335 OS=Homo sapiens OX=9606 GN=ZNF335 PE=1 SV=1 - [ZN335_HUMAN] 1.092 0.933 1.026 0.975 1.201 0.808 1.170418006 nan 0.81182348 nan 1.099678457 nan 0.672772689 nan GO:0006479;GO:0080090;GO:0019222;GO:0001701;GO:0048468;GO:0030900;GO:0043933;GO:0060322;GO:0051569;GO:0051568;GO:1901362;GO:1901360;GO:0044710;GO:0048869;GO:0070663;GO:0018193;GO:0048513;GO:0010720;GO:0048518;GO:0002682;GO:1902692;GO:0042127;GO:0016571;GO:0060255;GO:0046649;GO:0031060;GO:2001141;GO:0051128;GO:0046483;GO:0044707;GO:0019538;GO:0051094;GO:0080182;GO:0002376;GO:0018205;GO:0019438;GO:0016569;GO:0018023;GO:0018022;GO:0050670;GO:0031056;GO:0032943;GO:0006807;GO:0046651;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0000902;GO:0044260;GO:0016043;GO:0002684;GO:0065007;GO:0071840;GO:2000648;GO:0032259;GO:1903308;GO:0018130;GO:0009887;GO:0006139;GO:0050793;GO:0009889;GO:0050794;GO:0001775;GO:0051249;GO:0008150;GO:0008152;GO:0034654;GO:0021895;GO:0051962;GO:0016070;GO:0044271;GO:0007420;GO:0051276;GO:0043412;GO:0006355;GO:0048812;GO:0043414;GO:0051240;GO:0033044;GO:0032774;GO:0033043;GO:0030154;GO:0040029;GO:0044249;GO:0034641;GO:0009792;GO:2000179;GO:0034645;GO:0002696;GO:0009653;GO:0044699;GO:0007417;GO:0051960;GO:0051246;GO:0060284;GO:0050769;GO:0050865;GO:0034968;GO:2000177;GO:0036211;GO:0031399;GO:0072091;GO:0021953;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0045597;GO:0045595;GO:0002052;GO:0007405;GO:0043009;GO:0032990;GO:0008213;GO:0032268;GO:0045321;GO:0051251;GO:0051252;GO:0050671;GO:0051239;GO:0048731;GO:0072089;GO:0009790;GO:0050767;GO:1902275;GO:0008284;GO:0032944;GO:0030030;GO:0031326;GO:0050867;GO:0031175;GO:0031323;GO:0090304;GO:0007275;GO:0002694;GO:0006325;GO:2000112;GO:0032989;GO:0070661;GO:0071704;GO:0010467;GO:0010556;GO:0070665;GO:0061351;GO:2000026;GO:0010468;GO:0006351;GO:0048666;GO:0030182;GO:0044267;GO:0019219;GO:0006464;GO:0016570;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0022008;GO:0016568;GO:0006996;GO:0044238;GO:0048699;GO:0048858;GO:0007399;GO:0048854;GO:0048856;GO:0044237;GO:1902589;GO:0032946;GO:0048522; protein methylation;regulation of primary metabolic process;regulation of metabolic process;in utero embryonic development;cell development;forebrain development;macromolecular complex subunit organization;head development;regulation of histone H3-K4 methylation;histone H3-K4 methylation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;cellular developmental process;regulation of leukocyte proliferation;peptidyl-amino acid modification;animal organ development;positive regulation of cell development;positive regulation of biological process;regulation of immune system process;regulation of neuroblast proliferation;regulation of cell proliferation;histone methylation;regulation of macromolecule metabolic process;lymphocyte activation;regulation of histone methylation;regulation of RNA biosynthetic process;regulation of cellular component organization;heterocycle metabolic process;single-multicellular organism process;protein metabolic process;positive regulation of developmental process;histone H3-K4 trimethylation;immune system process;peptidyl-lysine modification;aromatic compound biosynthetic process;covalent chromatin modification;peptidyl-lysine trimethylation;peptidyl-lysine methylation;regulation of lymphocyte proliferation;regulation of histone modification;mononuclear cell proliferation;nitrogen compound metabolic process;lymphocyte proliferation;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;positive regulation of immune system process;biological regulation;cellular component organization or biogenesis;positive regulation of stem cell proliferation;methylation;regulation of chromatin modification;heterocycle biosynthetic process;organ morphogenesis;nucleobase-containing compound metabolic process;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;cell activation;regulation of lymphocyte activation;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;cerebral cortex neuron differentiation;positive regulation of nervous system development;RNA metabolic process;cellular nitrogen compound biosynthetic process;brain development;chromosome organization;macromolecule modification;regulation of transcription, DNA-templated;neuron projection morphogenesis;macromolecule methylation;positive regulation of multicellular organismal process;regulation of chromosome organization;RNA biosynthetic process;regulation of organelle organization;cell differentiation;regulation of gene expression, epigenetic;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;positive regulation of neural precursor cell proliferation;cellular macromolecule biosynthetic process;positive regulation of leukocyte activation;anatomical structure morphogenesis;single-organism process;central nervous system development;regulation of nervous system development;regulation of protein metabolic process;regulation of cell development;positive regulation of neurogenesis;regulation of cell activation;histone lysine methylation;regulation of neural precursor cell proliferation;protein modification process;regulation of protein modification process;regulation of stem cell proliferation;central nervous system neuron differentiation;developmental process;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of cell differentiation;regulation of cell differentiation;positive regulation of neuroblast proliferation;neuroblast proliferation;chordate embryonic development;cell part morphogenesis;protein alkylation;regulation of cellular protein metabolic process;leukocyte activation;positive regulation of lymphocyte activation;regulation of RNA metabolic process;positive regulation of lymphocyte proliferation;regulation of multicellular organismal process;system development;stem cell proliferation;embryo development;regulation of neurogenesis;regulation of chromatin organization;positive regulation of cell proliferation;regulation of mononuclear cell proliferation;cell projection organization;regulation of cellular biosynthetic process;positive regulation of cell activation;neuron projection development;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organism development;regulation of leukocyte activation;chromatin organization;regulation of cellular macromolecule biosynthetic process;cellular component morphogenesis;leukocyte proliferation;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;positive regulation of leukocyte proliferation;neural precursor cell proliferation;regulation of multicellular organismal development;regulation of gene expression;transcription, DNA-templated;neuron development;neuron differentiation;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;histone modification;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;neurogenesis;chromatin modification;organelle organization;primary metabolic process;generation of neurons;cell projection morphogenesis;nervous system development;brain morphogenesis;anatomical structure development;cellular metabolic process;single-organism organelle organization;positive regulation of mononuclear cell proliferation;positive regulation of cellular process; 5;4;3;8;4;4;4;4;7;7;5;4;3;4;5;7;4;5;2;3;6;4;5;4;4;6;6;4;4;3;4;3;8;2;8;5;7;7;6;6;5;5;3;5;4;2;7;4;5;4;3;3;2;2;5;3;7;5;4;4;3;4;3;4;5;1;2;5;5;4;5;5;4;5;5;6;6;4;3;6;6;5;5;6;4;4;6;5;5;4;3;2;5;5;5;5;5;4;6;5;5;6;5;6;2;2;3;2;4;7;4;4;6;5;7;5;7;5;3;5;5;6;3;4;4;5;6;6;4;6;4;5;4;5;4;5;4;4;5;6;4;4;3;5;5;5;4;4;5;6;5;6;5;5;6;4;3;3;5;3;4;6;6;4;3;7;5;5;5;3;3;4;6;3; GO:0031974;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0035097;GO:0044446;GO:0043226;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0005622;GO:0034708;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;histone methyltransferase complex;intracellular organelle part;organelle;nucleus;nucleoplasm part;cell part;cell;intracellular;methyltransferase complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;5;3;4;3;4;3;2;3;3;5;5;3;2;5;5;2;2;3;4;2;1;4; GO:1901363;GO:0046872;GO:0001067;GO:0044212;GO:0001012;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0000976;GO:0000977;GO:0000975;GO:0000979;GO:0043565;GO:1990837;GO:0003690;GO:0043169;GO:0001047;GO:0001046;GO:0043167; heterocyclic compound binding;metal ion binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter sequence-specific DNA binding;sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;cation binding;core promoter binding;core promoter sequence-specific DNA binding;ion binding; 3;5;5;7;8;1;2;4;5;3;8;9;6;10;6;7;6;4;8;9;3; IPR013087; Zinc finger C2H2-type; nucleus Hs11560152 2753.0 R [R] General function prediction only; Q14209 Transcription factor E2F2 OS=Homo sapiens OX=9606 GN=E2F2 PE=1 SV=1 - [E2F2_HUMAN] 0.964 0.776 0.848 0.7 0.753 5.174 1.242268041 0.510124824 0.929614874 0.674952162 1.092783505 0.891811027 6.871181939 0.089076302 GO:1901362;GO:1901360;GO:0051716;GO:0046483;GO:0044700;GO:0019438;GO:0007165;GO:0006807;GO:0035556;GO:0050789;GO:0097659;GO:0072332;GO:1901576;GO:0044260;GO:0065007;GO:0044699;GO:0006367;GO:0006366;GO:0018130;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0006351;GO:0006352;GO:0032774;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007049;GO:0006139;GO:1904019;GO:0009987;GO:0006725;GO:0043170;GO:0097190;GO:0097193;GO:0090304;GO:0008219;GO:0072331;GO:0071704;GO:0010467;GO:0000278;GO:1990086;GO:0006915;GO:0009058;GO:0009059;GO:0044763;GO:0007154;GO:0044238;GO:0051726;GO:0044237; organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;heterocycle metabolic process;single organism signaling;aromatic compound biosynthetic process;signal transduction;nitrogen compound metabolic process;intracellular signal transduction;regulation of biological process;nucleic acid-templated transcription;intrinsic apoptotic signaling pathway by p53 class mediator;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;single-organism process;transcription initiation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of cellular process;programmed cell death;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;transcription, DNA-templated;DNA-templated transcription, initiation;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell cycle;nucleobase-containing compound metabolic process;epithelial cell apoptotic process;cellular process;cellular aromatic compound metabolic process;macromolecule metabolic process;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;nucleic acid metabolic process;cell death;signal transduction by p53 class mediator;organic substance metabolic process;gene expression;mitotic cell cycle;lens fiber cell apoptotic process;apoptotic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cell communication;primary metabolic process;regulation of cell cycle;cellular metabolic process; 5;4;3;4;3;5;4;3;5;2;7;7;4;4;2;2;8;7;5;3;5;1;2;5;5;5;2;6;7;6;4;4;2;5;4;4;7;2;4;4;5;6;5;4;6;3;5;5;8;6;3;5;3;4;3;4;3; GO:0031974;GO:0031981;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0005667;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;transcription factor complex;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;3;4;3;4;4;3;2;3;3;3;5;3;5;2;2;2;2;1;4; GO:0001071;GO:1901363;GO:0044212;GO:0001067;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0000975;GO:0008134;GO:0005515;GO:0001047;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;transcription regulatory region DNA binding;regulatory region nucleic acid binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;regulatory region DNA binding;transcription factor binding;protein binding;core promoter binding;transcription factor activity, sequence-specific DNA binding; 2;3;7;5;1;2;4;5;3;6;4;3;8;3; K09389 map04110;map05161;map05166;map05200;map05206;map05212;map05214;map05215;map05218;map05219;map05220;map05222;map05223; Cell cycle;Hepatitis B;HTLV-I infection;Pathways in cancer;MicroRNAs in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer; IPR015633;IPR003316;IPR032198;IPR011991; E2F Family;E2F/DP family, winged-helix DNA-binding domain;E2F transcription factor, CC-MB domain;Winged helix-turn-helix DNA-binding domain; nucleus Hs4758226 878.0 K [K] Transcription; Q9P1W8 Signal-regulatory protein gamma OS=Homo sapiens OX=9606 GN=SIRPG PE=1 SV=3 - [SIRPG_HUMAN] 1.055 0.979 1.156 0.926 1.015 0.868 1.077630235 0.611576652 0.912315271 0.473424893 1.180796731 0.525892524 0.855172414 0.312330032 GO:0042127;GO:0002682;GO:0007599;GO:0034112;GO:0034110;GO:0050865;GO:0030155;GO:0007596;GO:0007165;GO:0050863;GO:0006928;GO:0022407;GO:0050900;GO:0098602;GO:0023052;GO:0016477;GO:0042110;GO:0016337;GO:0035556;GO:0050789;GO:0022409;GO:0002376;GO:0051716;GO:0051249;GO:0071593;GO:0045785;GO:0009611;GO:1903039;GO:0002684;GO:0002696;GO:0065007;GO:0044699;GO:0048518;GO:0048519;GO:0065008;GO:0050867;GO:1903037;GO:0008284;GO:0008285;GO:0032501;GO:0050878;GO:0008283;GO:0098609;GO:0034109;GO:0009987;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0050870;GO:0007155;GO:0007154;GO:0070486;GO:0007159;GO:0051179;GO:0040011;GO:0044700;GO:0022610;GO:0051674;GO:0044707;GO:0045321;GO:0051251;GO:0050896;GO:0048870;GO:0044763;GO:0001775;GO:0002694;GO:0046649;GO:0007267;GO:0070489;GO:0048523;GO:0048522; regulation of cell proliferation;regulation of immune system process;hemostasis;positive regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;regulation of cell activation;regulation of cell adhesion;blood coagulation;signal transduction;regulation of T cell activation;movement of cell or subcellular component;regulation of cell-cell adhesion;leukocyte migration;single organism cell adhesion;signaling;cell migration;T cell activation;single organismal cell-cell adhesion;intracellular signal transduction;regulation of biological process;positive regulation of cell-cell adhesion;immune system process;cellular response to stimulus;regulation of lymphocyte activation;lymphocyte aggregation;positive regulation of cell adhesion;response to wounding;positive regulation of leukocyte cell-cell adhesion;positive regulation of immune system process;positive regulation of leukocyte activation;biological regulation;single-organism process;positive regulation of biological process;negative regulation of biological process;regulation of biological quality;positive regulation of cell activation;regulation of leukocyte cell-cell adhesion;positive regulation of cell proliferation;negative regulation of cell proliferation;multicellular organismal process;regulation of body fluid levels;cell proliferation;cell-cell adhesion;homotypic cell-cell adhesion;cellular process;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;positive regulation of T cell activation;cell adhesion;cell communication;leukocyte aggregation;leukocyte cell-cell adhesion;localization;locomotion;single organism signaling;biological adhesion;localization of cell;single-multicellular organism process;leukocyte activation;positive regulation of lymphocyte activation;response to stimulus;cell motility;single-organism cellular process;cell activation;regulation of leukocyte activation;lymphocyte activation;cell-cell signaling;T cell aggregation;negative regulation of cellular process;positive regulation of cellular process; 4;3;5;6;6;4;4;5;4;6;4;5;3;3;2;4;5;4;5;2;5;2;3;5;7;4;4;6;3;4;2;2;2;2;3;4;6;4;4;2;4;3;4;5;2;5;3;3;4;1;6;3;4;6;5;2;2;3;2;3;3;3;5;2;3;3;4;4;4;4;4;3;3; GO:0044464;GO:0031224;GO:0016021;GO:0016020;GO:0071944;GO:0005886;GO:0005623;GO:0005622;GO:0005575;GO:0044425; cell part;intrinsic component of membrane;integral component of membrane;membrane;cell periphery;plasma membrane;cell;intracellular;cellular_component;membrane part; 2;3;4;2;3;3;2;3;1;2; K06551 map04380; Osteoclast differentiation; IPR003599;IPR007110;IPR013783;IPR003597;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin V-set domain; extracellular A6NCF6 Putative MAGE domain-containing protein MAGEA13P OS=Homo sapiens OX=9606 GN=MAGEA13P PE=5 SV=1 - [MA13P_HUMAN] 1.138 1.015 0.803 1.181 1.166 0.839 1.121182266 nan 1.012864494 nan 0.791133005 nan 0.719554031 nan IPR002190;IPR021072; MAGE homology domain;Melanoma associated antigen, N-terminal; cytosol Hs17485686 708.0 S [S] Function unknown; Q8N8A2 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3 - [ANR44_HUMAN] 1.212 0.922 0.827 1.149 0.889 1.831 1.314533623 nan 1.292463442 nan 0.896963124 nan 2.059617548 nan K15503 IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; cytosol Hs16159328 1352.0 R [R] General function prediction only; Q9UK61 Protein TASOR OS=Homo sapiens OX=9606 GN=FAM208A PE=1 SV=3 - [TASOR_HUMAN] 0.977 1.229 0.971 1.05 1.069 0.734 0.794955248 nan 0.98222638 nan 0.79007323 nan 0.686623012 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0043228;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0005694;GO:0043231;GO:0043232;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;nucleus;organelle;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;3;5;2;5;4;4;2;3;1;3; GO:0003674;GO:0003676;GO:0044822;GO:0097159;GO:0003723;GO:1901363;GO:0005488; molecular_function;nucleic acid binding;poly(A) RNA binding;organic cyclic compound binding;RNA binding;heterocyclic compound binding;binding; 1;4;6;3;5;3;2; K21873 IPR022188; Protein of unknown function DUF3715; nucleus Q16635 Tafazzin OS=Homo sapiens OX=9606 GN=TAZ PE=1 SV=1 - [TAZ_HUMAN] 0.789 0.822 1.769 0.936 0.812 0.6 0.959854015 0.622298899 1.15270936 0.332104462 2.152068127 0.025359433 0.738916256 0.169830559 GO:0061024;GO:0003012;GO:0072358;GO:0044281;GO:0009161;GO:0007007;GO:0007006;GO:0071840;GO:0044710;GO:0044711;GO:0007519;GO:0010257;GO:0009199;GO:0048513;GO:0022904;GO:0046483;GO:0009205;GO:0006936;GO:0006793;GO:0046034;GO:0046486;GO:0046128;GO:0055114;GO:0003008;GO:0022900;GO:1901564;GO:0044707;GO:0009167;GO:0072359;GO:0006163;GO:0003013;GO:0019637;GO:1901135;GO:0003015;GO:0022607;GO:0009141;GO:0009144;GO:0006807;GO:1901576;GO:0009126;GO:0016043;GO:0065003;GO:0007005;GO:0006119;GO:0006629;GO:0008015;GO:0009888;GO:0009150;GO:0044802;GO:0008152;GO:0046474;GO:0090407;GO:0002520;GO:0015980;GO:0008654;GO:0008150;GO:0006753;GO:0035965;GO:0070271;GO:0016310;GO:0009117;GO:0006941;GO:0044249;GO:0034641;GO:0060047;GO:0042407;GO:0061061;GO:0009123;GO:0060048;GO:0009259;GO:0044699;GO:0006139;GO:0042278;GO:0007517;GO:0032502;GO:0033108;GO:0006644;GO:0032501;GO:0044238;GO:0009987;GO:0006725;GO:0044255;GO:0055086;GO:0097031;GO:0048738;GO:0048731;GO:0046471;GO:0006655;GO:0006650;GO:0043933;GO:0002376;GO:0032049;GO:0032048;GO:0014706;GO:0019693;GO:0034622;GO:0072521;GO:0006091;GO:0007275;GO:0045017;GO:0071822;GO:0032981;GO:1901360;GO:0006796;GO:0071704;GO:0048534;GO:0045333;GO:0006461;GO:0044767;GO:0009058;GO:0044763;GO:0009116;GO:0009119;GO:0042775;GO:0043623;GO:0042773;GO:0008610;GO:0006996;GO:0007507;GO:0048856;GO:0044237;GO:0030097;GO:1901657;GO:1902589;GO:0044085;GO:0060537;GO:0060538; membrane organization;muscle system process;cardiovascular system development;small molecule metabolic process;ribonucleoside monophosphate metabolic process;inner mitochondrial membrane organization;mitochondrial membrane organization;cellular component organization or biogenesis;single-organism metabolic process;single-organism biosynthetic process;skeletal muscle tissue development;NADH dehydrogenase complex assembly;ribonucleoside triphosphate metabolic process;animal organ development;respiratory electron transport chain;heterocycle metabolic process;purine ribonucleoside triphosphate metabolic process;muscle contraction;phosphorus metabolic process;ATP metabolic process;glycerolipid metabolic process;purine ribonucleoside metabolic process;oxidation-reduction process;system process;electron transport chain;organonitrogen compound metabolic process;single-multicellular organism process;purine ribonucleoside monophosphate metabolic process;circulatory system development;purine nucleotide metabolic process;circulatory system process;organophosphate metabolic process;carbohydrate derivative metabolic process;heart process;cellular component assembly;nucleoside triphosphate metabolic process;purine nucleoside triphosphate metabolic process;nitrogen compound metabolic process;organic substance biosynthetic process;purine nucleoside monophosphate metabolic process;cellular component organization;macromolecular complex assembly;mitochondrion organization;oxidative phosphorylation;lipid metabolic process;blood circulation;tissue development;purine ribonucleotide metabolic process;single-organism membrane organization;metabolic process;glycerophospholipid biosynthetic process;organophosphate biosynthetic process;immune system development;energy derivation by oxidation of organic compounds;phospholipid biosynthetic process;biological_process;nucleoside phosphate metabolic process;cardiolipin acyl-chain remodeling;protein complex biogenesis;phosphorylation;nucleotide metabolic process;striated muscle contraction;cellular biosynthetic process;cellular nitrogen compound metabolic process;heart contraction;cristae formation;muscle structure development;nucleoside monophosphate metabolic process;cardiac muscle contraction;ribonucleotide metabolic process;single-organism process;nucleobase-containing compound metabolic process;purine nucleoside metabolic process;muscle organ development;developmental process;mitochondrial respiratory chain complex assembly;phospholipid metabolic process;multicellular organismal process;primary metabolic process;cellular process;cellular aromatic compound metabolic process;cellular lipid metabolic process;nucleobase-containing small molecule metabolic process;mitochondrial respiratory chain complex I biogenesis;cardiac muscle tissue development;system development;phosphatidylglycerol metabolic process;phosphatidylglycerol biosynthetic process;glycerophospholipid metabolic process;macromolecular complex subunit organization;immune system process;cardiolipin biosynthetic process;cardiolipin metabolic process;striated muscle tissue development;ribose phosphate metabolic process;cellular macromolecular complex assembly;purine-containing compound metabolic process;generation of precursor metabolites and energy;multicellular organism development;glycerolipid biosynthetic process;protein complex subunit organization;mitochondrial respiratory chain complex I assembly;organic cyclic compound metabolic process;phosphate-containing compound metabolic process;organic substance metabolic process;hematopoietic or lymphoid organ development;cellular respiration;protein complex assembly;single-organism developmental process;biosynthetic process;single-organism cellular process;nucleoside metabolic process;ribonucleoside metabolic process;mitochondrial ATP synthesis coupled electron transport;cellular protein complex assembly;ATP synthesis coupled electron transport;lipid biosynthetic process;organelle organization;heart development;anatomical structure development;cellular metabolic process;hemopoiesis;glycosyl compound metabolic process;single-organism organelle organization;cellular component biogenesis;muscle tissue development;skeletal muscle organ development; 4;4;5;4;7;6;5;2;3;4;7;7;7;4;5;4;8;5;4;8;5;7;4;3;4;4;3;8;5;6;4;4;4;5;4;6;7;3;4;7;3;5;5;5;4;5;4;7;4;2;6;5;3;4;5;1;5;9;4;6;6;6;4;4;6;7;4;6;7;6;2;4;6;5;2;6;5;2;3;2;4;4;4;5;5;4;7;7;6;4;2;8;8;6;5;6;5;4;4;5;5;6;4;5;3;4;5;5;3;3;3;5;6;7;6;6;5;4;4;3;3;5;4;4;3;5;6; GO:0031975;GO:0016021;GO:0016020;GO:0031967;GO:0031966;GO:0043231;GO:0005829;GO:0044429;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044424;GO:0031224;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005634;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0005575;GO:0019866; envelope;integral component of membrane;membrane;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;cytosol;mitochondrial part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;intracellular part;intrinsic component of membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;nucleus;mitochondrion;cell part;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;cellular_component;organelle inner membrane; 3;4;2;4;4;4;5;4;2;2;3;3;2;3;3;3;4;4;3;5;5;2;2;3;5;5;1;4; GO:0008374;GO:0016746;GO:0016747;GO:0003674;GO:0016740;GO:0003824;GO:0047184; O-acyltransferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups;molecular_function;transferase activity;catalytic activity;1-acylglycerophosphocholine O-acyltransferase activity; 6;4;5;1;3;2;7; K13511 map00564; Glycerophospholipid metabolism; IPR000872;IPR002123; Tafazzin;Phospholipid/glycerol acyltransferase; extracellular Hs4507371 608.0 I [I] Lipid transport and metabolism; Q8N0Z3 Spindle and centriole-associated protein 1 OS=Homo sapiens OX=9606 GN=SPICE1 PE=1 SV=1 - [SPICE_HUMAN] 1.241 1.075 0.74 1.213 1.153 0.473 1.154418605 0.916815129 1.052038161 0.150934405 0.688372093 0.306843007 0.410234172 0.009607326 GO:0051656;GO:0022607;GO:0051493;GO:0051234;GO:0070271;GO:0043933;GO:0010564;GO:0007099;GO:1903047;GO:0050000;GO:0010824;GO:0022402;GO:0016043;GO:0051301;GO:0098534;GO:0032886;GO:0007067;GO:0065003;GO:0051303;GO:0007049;GO:0046599;GO:0071822;GO:0050789;GO:0071840;GO:0033043;GO:0000280;GO:1902589;GO:0051225;GO:0065007;GO:1902850;GO:1902115;GO:0031023;GO:0000278;GO:0051297;GO:0006461;GO:0050794;GO:0051128;GO:0007051;GO:0007052;GO:0046605;GO:0008150;GO:0000226;GO:0051649;GO:0051310;GO:0007059;GO:0070925;GO:0051179;GO:0051640;GO:0051641;GO:0006996;GO:0044699;GO:0007017;GO:0007010;GO:0051726;GO:0098813;GO:0044087;GO:0090307;GO:0007098;GO:0048285;GO:0044763;GO:0009987;GO:0070507;GO:0051298;GO:0044085; establishment of organelle localization;cellular component assembly;regulation of cytoskeleton organization;establishment of localization;protein complex biogenesis;macromolecular complex subunit organization;regulation of cell cycle process;centriole replication;mitotic cell cycle process;chromosome localization;regulation of centrosome duplication;cell cycle process;cellular component organization;cell division;centriole assembly;regulation of microtubule-based process;mitotic nuclear division;macromolecular complex assembly;establishment of chromosome localization;cell cycle;regulation of centriole replication;protein complex subunit organization;regulation of biological process;cellular component organization or biogenesis;regulation of organelle organization;nuclear division;single-organism organelle organization;spindle assembly;biological regulation;microtubule cytoskeleton organization involved in mitosis;regulation of organelle assembly;microtubule organizing center organization;mitotic cell cycle;centrosome organization;protein complex assembly;regulation of cellular process;regulation of cellular component organization;spindle organization;mitotic spindle organization;regulation of centrosome cycle;biological_process;microtubule cytoskeleton organization;establishment of localization in cell;metaphase plate congression;chromosome segregation;organelle assembly;localization;organelle localization;cellular localization;organelle organization;single-organism process;microtubule-based process;cytoskeleton organization;regulation of cell cycle;nuclear chromosome segregation;regulation of cellular component biogenesis;mitotic spindle assembly;centrosome cycle;organelle fission;single-organism cellular process;cellular process;regulation of microtubule cytoskeleton organization;centrosome duplication;cellular component biogenesis; 4;4;6;3;4;4;5;5;5;5;6;4;3;4;5;4;5;5;5;4;5;5;2;2;5;6;4;6;2;6;4;5;5;6;5;3;4;5;6;6;1;5;4;6;4;5;2;4;3;4;2;4;5;4;5;3;6;5;5;3;2;5;5;3; GO:0043229;GO:0043228;GO:0043226;GO:0005737;GO:0005575;GO:0005819;GO:0005813;GO:0005814;GO:0005815;GO:0044430;GO:0044450;GO:0005856;GO:0015630;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0044444;GO:0044424;GO:0044422; intracellular organelle;non-membrane-bounded organelle;organelle;cytoplasm;cellular_component;spindle;centrosome;centriole;microtubule organizing center;cytoskeletal part;microtubule organizing center part;cytoskeleton;microtubule cytoskeleton;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;cytoplasmic part;intracellular part;organelle part; 3;3;2;4;1;5;5;5;5;4;5;5;6;4;2;2;3;3;4;3;2; K16490 IPR031387; Spindle and centriole-associated protein 1; nucleus P55058 Phospholipid transfer protein OS=Homo sapiens OX=9606 GN=PLTP PE=1 SV=1 - [PLTP_HUMAN] 0.941 1.011 1.105 0.958 1.038 1.051 0.930761622 0.271590401 0.922928709 0.877311243 1.09297725 0.326954768 1.012524085 0.310714136 GO:0030301;GO:0034375;GO:0006775;GO:0051050;GO:0015918;GO:0006869;GO:0043933;GO:0044237;GO:0006928;GO:0032373;GO:0044249;GO:0051674;GO:0010875;GO:0044283;GO:1901576;GO:0032879;GO:1901362;GO:0050789;GO:0044699;GO:0071825;GO:0044710;GO:0071827;GO:1901615;GO:0032374;GO:1901360;GO:0032376;GO:0032371;GO:0032370;GO:0016043;GO:0071704;GO:0033344;GO:0097006;GO:0071840;GO:0006810;GO:0071702;GO:0048518;GO:0065007;GO:0033036;GO:0018130;GO:0006766;GO:0032501;GO:0006629;GO:0034367;GO:0034368;GO:0034369;GO:0030317;GO:0009987;GO:0044765;GO:0044711;GO:0008150;GO:0008152;GO:0051234;GO:0010876;GO:0051179;GO:1902578;GO:0046483;GO:0040011;GO:0044238;GO:0051049;GO:0032368;GO:0044707;GO:0048870;GO:0042360;GO:0042362;GO:0015850;GO:0009058;GO:0009110;GO:0044763;GO:0010189;GO:0010874;GO:1901617;GO:0044281; cholesterol transport;high-density lipoprotein particle remodeling;fat-soluble vitamin metabolic process;positive regulation of transport;sterol transport;lipid transport;macromolecular complex subunit organization;cellular metabolic process;movement of cell or subcellular component;positive regulation of sterol transport;cellular biosynthetic process;localization of cell;positive regulation of cholesterol efflux;small molecule biosynthetic process;organic substance biosynthetic process;regulation of localization;organic cyclic compound biosynthetic process;regulation of biological process;single-organism process;protein-lipid complex subunit organization;single-organism metabolic process;plasma lipoprotein particle organization;organic hydroxy compound metabolic process;regulation of cholesterol transport;organic cyclic compound metabolic process;positive regulation of cholesterol transport;regulation of sterol transport;positive regulation of lipid transport;cellular component organization;organic substance metabolic process;cholesterol efflux;regulation of plasma lipoprotein particle levels;cellular component organization or biogenesis;transport;organic substance transport;positive regulation of biological process;biological regulation;macromolecule localization;heterocycle biosynthetic process;vitamin metabolic process;multicellular organismal process;lipid metabolic process;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;sperm motility;cellular process;single-organism transport;single-organism biosynthetic process;biological_process;metabolic process;establishment of localization;lipid localization;localization;single-organism localization;heterocycle metabolic process;locomotion;primary metabolic process;regulation of transport;regulation of lipid transport;single-multicellular organism process;cell motility;vitamin E metabolic process;fat-soluble vitamin biosynthetic process;organic hydroxy compound transport;biosynthetic process;vitamin biosynthetic process;single-organism cellular process;vitamin E biosynthetic process;regulation of cholesterol efflux;organic hydroxy compound biosynthetic process;small molecule metabolic process; 7;5;6;3;6;5;4;3;4;5;4;3;7;5;4;3;5;2;2;5;3;4;4;7;4;6;6;4;3;3;8;3;2;4;5;2;2;3;5;5;2;4;5;6;4;4;2;4;4;1;2;3;4;2;3;4;2;3;4;5;3;3;4;5;5;3;4;3;5;8;5;4; GO:0005615;GO:0044421;GO:0005575;GO:0005576; extracellular space;extracellular region part;cellular_component;extracellular region; 3;2;1;2; GO:0003674;GO:0005488;GO:0008289; molecular_function;binding;lipid binding; 1;2;3; K08761 map03320; PPAR signaling pathway; IPR017954;IPR030675;IPR017943;IPR017942;IPR001124;IPR030179;IPR032942; Lipid-binding serum glycoprotein, conserved site;Lipid binding protein BPI/LBP;Bactericidal permeability-increasing protein, alpha/beta domain;Lipid-binding serum glycoprotein, N-terminal;Lipid-binding serum glycoprotein, C-terminal;Phospholipid transfer protein;BPI/LBP/Plunc family; extracellular Hs5453914 1011.0 V [V] Defense mechanisms; P13569 Cystic fibrosis transmembrane conductance regulator OS=Homo sapiens OX=9606 GN=CFTR PE=1 SV=3 - [CFTR_HUMAN] 0.735 0.803 1.568 0.637 1.562 nan 0.915317559 nan 0.407810499 nan 1.95267746 nan nan nan GO:0035774;GO:0090087;GO:0051046;GO:0051047;GO:0051049;GO:0044281;GO:0044283;GO:0098771;GO:0051716;GO:0000003;GO:0035773;GO:0006904;GO:0045852;GO:0048468;GO:0098660;GO:0048469;GO:0007281;GO:0007283;GO:0007286;GO:0034284;GO:2001225;GO:0032414;GO:0032411;GO:0032412;GO:0051222;GO:0051223;GO:0050789;GO:0030073;GO:0006885;GO:0006887;GO:2000273;GO:0070201;GO:0006629;GO:0009306;GO:0050714;GO:0006694;GO:0048869;GO:0051453;GO:0014074;GO:0014070;GO:0051454;GO:0061178;GO:0006873;GO:0046883;GO:0046887;GO:0042592;GO:0051591;GO:0045921;GO:0060341;GO:0022406;GO:0042593;GO:0007276;GO:0046683;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0048856;GO:0048522;GO:0008104;GO:0007165;GO:0044710;GO:0044711;GO:0071331;GO:0044093;GO:0071333;GO:0033036;GO:0051050;GO:1902653;GO:0048278;GO:0010033;GO:1903959;GO:0051704;GO:0070887;GO:0015918;GO:0015850;GO:0050796;GO:0050794;GO:0051234;GO:0022898;GO:0050896;GO:0042391;GO:0019953;GO:1903530;GO:0010359;GO:1903532;GO:0044699;GO:0032880;GO:0032409;GO:0016126;GO:0016125;GO:0048609;GO:0043270;GO:0048232;GO:1901529;GO:0009914;GO:0035556;GO:1903961;GO:0006066;GO:0048240;GO:0030072;GO:0010817;GO:0022414;GO:0055067;GO:0022412;GO:0007267;GO:0042221;GO:0007264;GO:0008610;GO:0009746;GO:0044238;GO:0009743;GO:0002790;GO:0002791;GO:0002793;GO:0009749;GO:1902161;GO:0032024;GO:0048584;GO:0048583;GO:0032846;GO:0032844;GO:0060081;GO:1901362;GO:1901360;GO:0009966;GO:0009967;GO:0046879;GO:0048515;GO:0048518;GO:0045184;GO:0003006;GO:0044700;GO:0044703;GO:0044702;GO:0016192;GO:0044707;GO:0071322;GO:0010243;GO:0071320;GO:0071326;GO:0006695;GO:1902943;GO:1902941;GO:0006811;GO:0006810;GO:0001678;GO:0046903;GO:1901617;GO:1901615;GO:0030154;GO:0015833;GO:1904951;GO:0009719;GO:0017157;GO:0032502;GO:0032501;GO:0032504;GO:0009987;GO:0060627;GO:0032879;GO:0071407;GO:0043269;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0015698;GO:1902476;GO:0007585;GO:0023061;GO:0034220;GO:0009058;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:1902652;GO:0021700;GO:0090277;GO:0006820;GO:0006821;GO:0034764;GO:0034765;GO:0034767;GO:0034762;GO:0019725;GO:1902159;GO:0090276;GO:0010876;GO:0048878;GO:1903793;GO:1903795;GO:1903797;GO:0032940;GO:1901576;GO:0050708;GO:0065007;GO:0098661;GO:0065009;GO:0065008;GO:0008150;GO:0008152;GO:1901698;GO:1901699;GO:0006869;GO:0050801;GO:0030301;GO:0023056;GO:0023052;GO:0023051;GO:0010647;GO:0010646;GO:0042886;GO:0046165;GO:0030004;GO:0030003;GO:0055080;GO:0055082;GO:0055085;GO:0008202;GO:0008203;GO:0071495;GO:0044070;GO:0030641;GO:0071417;GO:0033500;GO:0010469;GO:0015031;GO:0007154;GO:0098656; positive regulation of insulin secretion involved in cellular response to glucose stimulus;regulation of peptide transport;regulation of secretion;positive regulation of secretion;regulation of transport;small molecule metabolic process;small molecule biosynthetic process;inorganic ion homeostasis;cellular response to stimulus;reproduction;insulin secretion involved in cellular response to glucose stimulus;vesicle docking involved in exocytosis;pH elevation;cell development;inorganic ion transmembrane transport;cell maturation;germ cell development;spermatogenesis;spermatid development;response to monosaccharide;regulation of chloride transport;positive regulation of ion transmembrane transporter activity;positive regulation of transporter activity;regulation of ion transmembrane transporter activity;positive regulation of protein transport;regulation of protein transport;regulation of biological process;insulin secretion;regulation of pH;exocytosis;positive regulation of receptor activity;regulation of establishment of protein localization;lipid metabolic process;protein secretion;positive regulation of protein secretion;steroid biosynthetic process;cellular developmental process;regulation of intracellular pH;response to purine-containing compound;response to organic cyclic compound;intracellular pH elevation;regulation of insulin secretion involved in cellular response to glucose stimulus;cellular ion homeostasis;regulation of hormone secretion;positive regulation of hormone secretion;homeostatic process;response to cAMP;positive regulation of exocytosis;regulation of cellular localization;membrane docking;glucose homeostasis;gamete generation;response to organophosphorus;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;anatomical structure development;positive regulation of cellular process;protein localization;signal transduction;single-organism metabolic process;single-organism biosynthetic process;cellular response to hexose stimulus;positive regulation of molecular function;cellular response to glucose stimulus;macromolecule localization;positive regulation of transport;secondary alcohol biosynthetic process;vesicle docking;response to organic substance;regulation of anion transmembrane transport;multi-organism process;cellular response to chemical stimulus;sterol transport;organic hydroxy compound transport;regulation of insulin secretion;regulation of cellular process;establishment of localization;regulation of transmembrane transporter activity;response to stimulus;regulation of membrane potential;sexual reproduction;regulation of secretion by cell;regulation of anion channel activity;positive regulation of secretion by cell;single-organism process;regulation of protein localization;regulation of transporter activity;sterol biosynthetic process;sterol metabolic process;multicellular organismal reproductive process;positive regulation of ion transport;male gamete generation;positive regulation of anion channel activity;hormone transport;intracellular signal transduction;positive regulation of anion transmembrane transport;alcohol metabolic process;sperm capacitation;peptide hormone secretion;regulation of hormone levels;reproductive process;monovalent inorganic cation homeostasis;cellular process involved in reproduction in multicellular organism;cell-cell signaling;response to chemical;small GTPase mediated signal transduction;lipid biosynthetic process;response to hexose;primary metabolic process;response to carbohydrate;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;response to glucose;positive regulation of cyclic nucleotide-gated ion channel activity;positive regulation of insulin secretion;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of homeostatic process;regulation of homeostatic process;membrane hyperpolarization;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of signal transduction;positive regulation of signal transduction;hormone secretion;spermatid differentiation;positive regulation of biological process;establishment of protein localization;developmental process involved in reproduction;single organism signaling;multi-organism reproductive process;single organism reproductive process;vesicle-mediated transport;single-multicellular organism process;cellular response to carbohydrate stimulus;response to organonitrogen compound;cellular response to cAMP;cellular response to monosaccharide stimulus;cholesterol biosynthetic process;positive regulation of voltage-gated chloride channel activity;regulation of voltage-gated chloride channel activity;ion transport;transport;cellular glucose homeostasis;secretion;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;cell differentiation;peptide transport;positive regulation of establishment of protein localization;response to endogenous stimulus;regulation of exocytosis;developmental process;multicellular organismal process;multicellular organism reproduction;cellular process;regulation of vesicle-mediated transport;regulation of localization;cellular response to organic cyclic compound;regulation of ion transport;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;inorganic anion transport;chloride transmembrane transport;respiratory gaseous exchange;signal release;ion transmembrane transport;biosynthetic process;establishment of localization in cell;localization;single-organism localization;cellular localization;secondary alcohol metabolic process;developmental maturation;positive regulation of peptide hormone secretion;anion transport;chloride transport;positive regulation of transmembrane transport;regulation of ion transmembrane transport;positive regulation of ion transmembrane transport;regulation of transmembrane transport;cellular homeostasis;regulation of cyclic nucleotide-gated ion channel activity;regulation of peptide hormone secretion;lipid localization;chemical homeostasis;positive regulation of anion transport;regulation of inorganic anion transmembrane transport;positive regulation of inorganic anion transmembrane transport;secretion by cell;organic substance biosynthetic process;regulation of protein secretion;biological regulation;inorganic anion transmembrane transport;regulation of molecular function;regulation of biological quality;biological_process;metabolic process;response to nitrogen compound;cellular response to nitrogen compound;lipid transport;ion homeostasis;cholesterol transport;positive regulation of signaling;signaling;regulation of signaling;positive regulation of cell communication;regulation of cell communication;amide transport;alcohol biosynthetic process;cellular monovalent inorganic cation homeostasis;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;steroid metabolic process;cholesterol metabolic process;cellular response to endogenous stimulus;regulation of anion transport;regulation of cellular pH;cellular response to organonitrogen compound;carbohydrate homeostasis;regulation of receptor activity;protein transport;cell communication;anion transmembrane transport; 4;5;5;4;4;4;5;7;3;2;5;6;10;4;6;5;4;6;5;6;7;5;4;6;4;5;2;6;9;5;5;5;4;5;5;6;4;10;5;5;11;4;6;4;4;4;5;5;4;4;7;4;5;3;4;3;4;5;3;3;4;4;3;4;8;4;7;3;3;7;5;4;6;2;4;6;5;6;3;3;5;2;4;3;5;7;4;2;4;4;7;6;3;4;5;6;5;5;6;5;4;7;4;2;8;4;4;3;6;5;7;3;5;6;6;5;8;5;6;3;3;3;3;5;5;4;4;4;6;4;2;4;3;3;3;3;5;3;6;4;6;7;8;7;8;5;4;6;5;5;4;5;6;3;3;5;2;2;3;2;4;3;6;5;5;3;5;5;7;8;4;5;5;3;4;2;3;3;6;4;5;6;8;4;5;5;4;4;5;5;4;5;5;7;7;4;4;6;2;7;3;3;1;2;4;5;5;6;7;3;2;3;4;4;5;6;8;7;7;5;4;5;7;4;6;9;5;6;4;5;4;6; GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0005773;GO:0045177;GO:0016324;GO:0016323;GO:0044464;GO:0071944;GO:0070062;GO:0005737;GO:0005764;GO:0005765;GO:0005768;GO:0005769;GO:0016023;GO:0016021;GO:0016020;GO:0055037;GO:1902495;GO:0098588;GO:0098589;GO:0043234;GO:0043230;GO:0043231;GO:0005829;GO:0034707;GO:0034702;GO:0044433;GO:0044431;GO:0044437;GO:1990351;GO:0031090;GO:0030660;GO:0005774;GO:0031901;GO:0098852;GO:0098590;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0044446;GO:0044444;GO:0044440;GO:0000323;GO:0012506;GO:0009986;GO:0030659;GO:0005798;GO:0098805;GO:0031982;GO:0031988;GO:0005794;GO:0010008;GO:0031224;GO:0097708;GO:0000139;GO:0031410;GO:0044459;GO:0005623;GO:0005622;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0098796;GO:0005576; intracellular part;membrane part;extracellular region part;organelle part;vacuole;apical part of cell;apical plasma membrane;basolateral plasma membrane;cell part;cell periphery;extracellular exosome;cytoplasm;lysosome;lysosomal membrane;endosome;early endosome;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;recycling endosome;transmembrane transporter complex;bounding membrane of organelle;membrane region;protein complex;extracellular organelle;intracellular membrane-bounded organelle;cytosol;chloride channel complex;ion channel complex;cytoplasmic vesicle part;Golgi apparatus part;vacuolar part;transporter complex;organelle membrane;Golgi-associated vesicle membrane;vacuolar membrane;early endosome membrane;lytic vacuole membrane;plasma membrane region;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;intracellular organelle part;cytoplasmic part;endosomal part;lytic vacuole;vesicle membrane;cell surface;cytoplasmic vesicle membrane;Golgi-associated vesicle;whole membrane;vesicle;membrane-bounded vesicle;Golgi apparatus;endosome membrane;intrinsic component of membrane;intracellular vesicle;Golgi membrane;cytoplasmic vesicle;plasma membrane part;cell;intracellular;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;membrane protein complex;extracellular region; 3;2;2;2;5;3;4;4;2;3;4;4;7;6;4;5;5;4;2;5;4;4;3;3;3;4;5;6;5;4;4;4;4;3;4;4;6;5;4;3;3;2;3;3;4;5;6;4;3;5;5;3;4;5;4;5;3;4;5;5;3;2;3;3;3;2;1;3;2; GO:0098772;GO:0000166;GO:0016818;GO:0016817;GO:0005488;GO:1901265;GO:0015399;GO:0017076;GO:0016787;GO:0015075;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0005224;GO:0019869;GO:0043492;GO:0001883;GO:0001882;GO:0015267;GO:0008514;GO:0022857;GO:0005260;GO:0099600;GO:0022891;GO:0022892;GO:0017081;GO:0019899;GO:0005215;GO:0005216;GO:0005217;GO:0005515;GO:0016248;GO:0016247;GO:0017111;GO:0060089;GO:1901363;GO:0008509;GO:0019904;GO:0015405;GO:0003674;GO:0016887;GO:0042626;GO:0042623;GO:0005253;GO:0005254;GO:0005524;GO:0003824;GO:0097159;GO:0015276;GO:0043167;GO:0030554;GO:0022836;GO:0022834;GO:0022838;GO:0036094;GO:0030165;GO:0097367;GO:0032549;GO:0022803;GO:0022804;GO:0043168;GO:0016462;GO:0035639;GO:0016820;GO:0008200;GO:0004872;GO:0015106;GO:0015103;GO:0015108; molecular function regulator;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;binding;nucleoside phosphate binding;primary active transmembrane transporter activity;purine nucleotide binding;hydrolase activity;ion transmembrane transporter activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-binding and phosphorylation-dependent chloride channel activity;chloride channel inhibitor activity;ATPase activity, coupled to movement of substances;purine nucleoside binding;nucleoside binding;channel activity;organic anion transmembrane transporter activity;transmembrane transporter activity;channel-conductance-controlling ATPase activity;transmembrane receptor activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;chloride channel regulator activity;enzyme binding;transporter activity;ion channel activity;intracellular ligand-gated ion channel activity;protein binding;channel inhibitor activity;channel regulator activity;nucleoside-triphosphatase activity;molecular transducer activity;heterocyclic compound binding;anion transmembrane transporter activity;protein domain specific binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;molecular_function;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;anion channel activity;chloride channel activity;ATP binding;catalytic activity;organic cyclic compound binding;ligand-gated ion channel activity;ion binding;adenyl nucleotide binding;gated channel activity;ligand-gated channel activity;substrate-specific channel activity;small molecule binding;PDZ domain binding;carbohydrate derivative binding;ribonucleoside binding;passive transmembrane transporter activity;active transmembrane transporter activity;anion binding;pyrophosphatase activity;purine ribonucleoside triphosphate binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ion channel inhibitor activity;receptor activity;bicarbonate transmembrane transporter activity;inorganic anion transmembrane transporter activity;chloride transmembrane transporter activity; 2;4;5;4;2;4;5;5;3;5;6;5;6;4;8;5;10;5;4;5;7;3;7;4;4;3;4;4;2;6;7;3;4;3;7;2;3;6;4;6;1;8;6;9;7;8;6;2;3;6;3;6;6;5;5;3;5;3;5;4;4;4;6;5;5;5;3;8;7;8; K05031 map02010;map04024;map04152;map04971;map04972;map04976;map05110; ABC transporters;cAMP signaling pathway;AMPK signaling pathway;Gastric acid secretion;Pancreatic secretion;Bile secretion;Vibrio cholerae infection; IPR017871;IPR009147;IPR003593;IPR003439;IPR011527;IPR025837;IPR027417; ABC transporter, conserved site;Cystic fibrosis transmembrane conductance regulator;AAA+ ATPase domain;ABC transporter-like;ABC transporter type 1, transmembrane domain;CFTR regulator domain;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Hs6995996 3040.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q9UNN8 Endothelial protein C receptor OS=Homo sapiens OX=9606 GN=PROCR PE=1 SV=1 - [EPCR_HUMAN] 1.006 1.141 0.77 1.12 1.06 1.598 0.881682734 nan 1.056603774 nan 0.674846626 nan 1.50754717 nan GO:0051241;GO:0007599;GO:0002376;GO:0007596;GO:0006928;GO:0044699;GO:0051674;GO:0050789;GO:0006955;GO:0009611;GO:0065007;GO:0048519;GO:0065008;GO:0032501;GO:0050878;GO:0009987;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0050818;GO:0051179;GO:0051239;GO:0040011;GO:0016477;GO:0044707;GO:0048870;GO:0050896;GO:0050900;GO:0050819;GO:0044763; negative regulation of multicellular organismal process;hemostasis;immune system process;blood coagulation;movement of cell or subcellular component;single-organism process;localization of cell;regulation of biological process;immune response;response to wounding;biological regulation;negative regulation of biological process;regulation of biological quality;multicellular organismal process;regulation of body fluid levels;cellular process;wound healing;response to stress;coagulation;biological_process;regulation of coagulation;localization;regulation of multicellular organismal process;locomotion;cell migration;single-multicellular organism process;cell motility;response to stimulus;leukocyte migration;negative regulation of coagulation;single-organism cellular process; 3;5;2;5;4;2;3;2;3;4;2;2;3;2;4;2;5;3;4;1;4;2;3;2;4;3;3;2;3;4;3; GO:0005887;GO:0043229;GO:0043228;GO:0070161;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0030055;GO:0005856;GO:0005575;GO:0070062;GO:0005813;GO:0016021;GO:0016020;GO:0005815;GO:0044430;GO:0031224;GO:0044425;GO:0044459;GO:0015630;GO:0009986;GO:0071944;GO:0005912;GO:0031226;GO:0005886;GO:1903561;GO:0031982;GO:0043230;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0005576;GO:0044424;GO:0030054;GO:0044421;GO:0044422; integral component of plasma membrane;intracellular organelle;non-membrane-bounded organelle;anchoring junction;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;cell-substrate junction;cytoskeleton;cellular_component;extracellular exosome;centrosome;integral component of membrane;membrane;microtubule organizing center;cytoskeletal part;intrinsic component of membrane;membrane part;plasma membrane part;microtubule cytoskeleton;cell surface;cell periphery;adherens junction;intrinsic component of plasma membrane;plasma membrane;extracellular vesicle;vesicle;extracellular organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;extracellular region;intracellular part;cell junction;extracellular region part;organelle part; 4;3;3;3;4;5;3;2;3;5;1;4;5;4;2;5;4;3;2;3;6;3;3;4;4;3;3;4;3;4;2;2;3;3;2;3;2;2;2; GO:0060089;GO:0003674;GO:0004872; molecular transducer activity;molecular_function;receptor activity; 2;1;3; K06557 map04610; Complement and coagulation cascades; IPR015669;IPR011162;IPR011161; Endothelial protein C receptor;MHC classes I/II-like antigen recognition protein;MHC class I-like antigen recognition-like; plasma membrane O95613 Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4 - [PCNT_HUMAN] 1.125 0.699 1.16 1.489 0.406 2.229 1.60944206 nan 3.667487685 nan 1.659513591 nan 5.490147783 nan GO:0033157;GO:0008104;GO:0032388;GO:0000086;GO:0051049;GO:0032386;GO:0071840;GO:0070727;GO:0048869;GO:0048518;GO:0033036;GO:0051050;GO:0045184;GO:0044782;GO:0022607;GO:0000226;GO:0051222;GO:0051223;GO:0050789;GO:0009653;GO:0000902;GO:0006886;GO:0016043;GO:0065007;GO:1903829;GO:0048646;GO:0070201;GO:0042384;GO:0060271;GO:0006810;GO:0050794;GO:0007051;GO:0007052;GO:0008150;GO:0051234;GO:0046907;GO:0010927;GO:1903827;GO:1904951;GO:0007049;GO:0032880;GO:0060341;GO:0043933;GO:0032502;GO:0009987;GO:0032879;GO:0032990;GO:0044699;GO:0044839;GO:0030030;GO:0030031;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0071822;GO:0071702;GO:0000278;GO:0034613;GO:0090316;GO:0044767;GO:0044763;GO:0051649;GO:0070925;GO:0051179;GO:0051641;GO:0006996;GO:0007017;GO:0007010;GO:0048858;GO:0048856;GO:1902589;GO:0044085;GO:0032989;GO:0015031; regulation of intracellular protein transport;protein localization;positive regulation of intracellular transport;G2/M transition of mitotic cell cycle;regulation of transport;regulation of intracellular transport;cellular component organization or biogenesis;cellular macromolecule localization;cellular developmental process;positive regulation of biological process;macromolecule localization;positive regulation of transport;establishment of protein localization;cilium organization;cellular component assembly;microtubule cytoskeleton organization;positive regulation of protein transport;regulation of protein transport;regulation of biological process;anatomical structure morphogenesis;cell morphogenesis;intracellular protein transport;cellular component organization;biological regulation;positive regulation of cellular protein localization;anatomical structure formation involved in morphogenesis;regulation of establishment of protein localization;cilium assembly;cilium morphogenesis;transport;regulation of cellular process;spindle organization;mitotic spindle organization;biological_process;establishment of localization;intracellular transport;cellular component assembly involved in morphogenesis;regulation of cellular protein localization;positive regulation of establishment of protein localization;cell cycle;regulation of protein localization;regulation of cellular localization;macromolecular complex subunit organization;developmental process;cellular process;regulation of localization;cell part morphogenesis;single-organism process;cell cycle G2/M phase transition;cell projection organization;cell projection assembly;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;protein complex subunit organization;organic substance transport;mitotic cell cycle;cellular protein localization;positive regulation of intracellular protein transport;single-organism developmental process;single-organism cellular process;establishment of localization in cell;organelle assembly;localization;cellular localization;organelle organization;microtubule-based process;cytoskeleton organization;cell projection morphogenesis;anatomical structure development;single-organism organelle organization;cellular component biogenesis;cellular component morphogenesis;protein transport; 6;4;4;6;4;5;2;4;4;2;3;3;4;5;4;5;4;5;2;3;5;6;3;2;3;3;5;5;6;4;3;5;6;1;3;5;4;5;3;4;4;4;4;2;2;3;5;2;6;4;5;5;5;6;4;5;5;5;5;4;3;3;4;5;2;3;4;4;5;5;3;4;3;4;5; GO:0099513;GO:0099512;GO:0005815;GO:0016020;GO:0015630;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005856;GO:0044430;GO:0044446;GO:0044444;GO:0005874;GO:0005737;GO:0044450;GO:0044464;GO:0005623;GO:0005622;GO:0005813;GO:0005814;GO:0043226;GO:0034451;GO:0005575; polymeric cytoskeletal fiber;supramolecular fiber;microtubule organizing center;membrane;microtubule cytoskeleton;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;cytoplasmic part;microtubule;cytoplasm;microtubule organizing center part;cell part;cell;intracellular;centrosome;centriole;organelle;centriolar satellite;cellular_component; 3;2;5;2;6;4;5;3;2;3;3;5;4;3;4;4;4;5;2;2;3;5;5;2;6;1; K16481 IPR024151;IPR019528; Pericentrin;Pericentrin/AKAP-450 centrosomal targeting domain; nucleus Q96K62 Zinc finger and BTB domain-containing protein 45 OS=Homo sapiens OX=9606 GN=ZBTB45 PE=2 SV=1 - [ZBT45_HUMAN] 0.8 0.949 1.477 0.894 1 0.885 0.842992624 nan 0.894 nan 1.556375132 nan 0.885 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; K10516 IPR013087;IPR000210;IPR013083;IPR011333; Zinc finger C2H2-type;BTB/POZ domain;Zinc finger, RING/FYVE/PHD-type;SKP1/BTB/POZ domain; nucleus Hs14249464 1019.0 R [R] General function prediction only; Q9UNN5 FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2 - [FAF1_HUMAN] 0.962 1.024 1.167 0.885 0.955 0.953 0.939453125 0.690452368 0.926701571 0.503737972 1.139648438 0.175976767 0.997905759 0.428661618 GO:0090087;GO:2001235;GO:2001236;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0033157;GO:0051049;GO:0032386;GO:0048584;GO:0048583;GO:0051169;GO:0007165;GO:0007166;GO:0051651;GO:0042347;GO:0071840;GO:0071705;GO:0051716;GO:0009968;GO:0070727;GO:0009966;GO:0009967;GO:0031323;GO:1904590;GO:0048518;GO:0048519;GO:0033036;GO:0048585;GO:0043122;GO:0031503;GO:0032387;GO:0051051;GO:0060255;GO:2001238;GO:0045859;GO:0006606;GO:0006605;GO:0045184;GO:0045185;GO:0030163;GO:0042994;GO:0042992;GO:0065009;GO:0042990;GO:0042991;GO:0044700;GO:0019538;GO:0015833;GO:1904589;GO:1902531;GO:0009894;GO:0022607;GO:1903650;GO:0051220;GO:0035556;GO:0051223;GO:0042981;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0006886;GO:0043549;GO:0016043;GO:0065003;GO:0065007;GO:0065008;GO:0051130;GO:0070201;GO:0034613;GO:1903649;GO:0042325;GO:0006810;GO:0050794;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0042308;GO:1902532;GO:0042306;GO:0051235;GO:0051234;GO:1900181;GO:1900180;GO:0046907;GO:0050896;GO:0010498;GO:0051338;GO:0006511;GO:0046822;GO:0046823;GO:0043161;GO:0051170;GO:1902043;GO:1902041;GO:0070271;GO:0016310;GO:0030155;GO:0051649;GO:0051128;GO:0023056;GO:0023057;GO:0042176;GO:0023052;GO:0010648;GO:1903533;GO:0023051;GO:0010647;GO:0010646;GO:0043254;GO:0044699;GO:0032880;GO:0042886;GO:0008625;GO:0007253;GO:0007249;GO:0051246;GO:0051179;GO:0044248;GO:0031399;GO:2001233;GO:0006508;GO:1904950;GO:0022610;GO:0050790;GO:0032507;GO:1902593;GO:0072594;GO:0009987;GO:0019941;GO:0043124;GO:0044257;GO:0044744;GO:0032879;GO:0016482;GO:0006461;GO:0032268;GO:0043170;GO:1903828;GO:0033365;GO:0034504;GO:0060341;GO:0043933;GO:0097190;GO:0097191;GO:0044089;GO:0010942;GO:0008219;GO:0010941;GO:0043632;GO:0071822;GO:0044087;GO:0051224;GO:1903827;GO:0043065;GO:0071704;GO:0043067;GO:0051603;GO:0071702;GO:0043068;GO:0006468;GO:0017038;GO:0031334;GO:0006915;GO:0090317;GO:0006913;GO:0006464;GO:0051174;GO:0044765;GO:0044763;GO:0007155;GO:0007154;GO:0009056;GO:0009057;GO:1902578;GO:0051641;GO:0044238;GO:0001932;GO:0042345;GO:0042348;GO:0044237;GO:0006796;GO:0044085;GO:0006793;GO:0015031;GO:1902582;GO:1902580;GO:0048523;GO:0048522; regulation of peptide transport;positive regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of intracellular protein transport;regulation of transport;regulation of intracellular transport;positive regulation of response to stimulus;regulation of response to stimulus;nuclear transport;signal transduction;cell surface receptor signaling pathway;maintenance of location in cell;negative regulation of NF-kappaB import into nucleus;cellular component organization or biogenesis;nitrogen compound transport;cellular response to stimulus;negative regulation of signal transduction;cellular macromolecule localization;regulation of signal transduction;positive regulation of signal transduction;regulation of cellular metabolic process;negative regulation of protein import;positive regulation of biological process;negative regulation of biological process;macromolecule localization;negative regulation of response to stimulus;regulation of I-kappaB kinase/NF-kappaB signaling;protein complex localization;negative regulation of intracellular transport;negative regulation of transport;regulation of macromolecule metabolic process;positive regulation of extrinsic apoptotic signaling pathway;regulation of protein kinase activity;protein import into nucleus;protein targeting;establishment of protein localization;maintenance of protein location;protein catabolic process;cytoplasmic sequestering of transcription factor;negative regulation of transcription factor import into nucleus;regulation of molecular function;regulation of transcription factor import into nucleus;transcription factor import into nucleus;single organism signaling;protein metabolic process;peptide transport;regulation of protein import;regulation of intracellular signal transduction;regulation of catabolic process;cellular component assembly;negative regulation of cytoplasmic transport;cytoplasmic sequestering of protein;intracellular signal transduction;regulation of protein transport;regulation of apoptotic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;intracellular protein transport;regulation of kinase activity;cellular component organization;macromolecular complex assembly;biological regulation;regulation of biological quality;positive regulation of cellular component organization;regulation of establishment of protein localization;cellular protein localization;regulation of cytoplasmic transport;regulation of phosphorylation;transport;regulation of cellular process;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;negative regulation of protein import into nucleus;negative regulation of intracellular signal transduction;regulation of protein import into nucleus;maintenance of location;establishment of localization;negative regulation of protein localization to nucleus;regulation of protein localization to nucleus;intracellular transport;response to stimulus;proteasomal protein catabolic process;regulation of transferase activity;ubiquitin-dependent protein catabolic process;regulation of nucleocytoplasmic transport;negative regulation of nucleocytoplasmic transport;proteasome-mediated ubiquitin-dependent protein catabolic process;nuclear import;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of extrinsic apoptotic signaling pathway via death domain receptors;protein complex biogenesis;phosphorylation;regulation of cell adhesion;establishment of localization in cell;regulation of cellular component organization;positive regulation of signaling;negative regulation of signaling;regulation of protein catabolic process;signaling;negative regulation of cell communication;regulation of protein targeting;regulation of signaling;positive regulation of cell communication;regulation of cell communication;regulation of protein complex assembly;single-organism process;regulation of protein localization;amide transport;extrinsic apoptotic signaling pathway via death domain receptors;cytoplasmic sequestering of NF-kappaB;I-kappaB kinase/NF-kappaB signaling;regulation of protein metabolic process;localization;cellular catabolic process;regulation of protein modification process;regulation of apoptotic signaling pathway;proteolysis;negative regulation of establishment of protein localization;biological adhesion;regulation of catalytic activity;maintenance of protein location in cell;single-organism nuclear import;establishment of protein localization to organelle;cellular process;modification-dependent protein catabolic process;negative regulation of I-kappaB kinase/NF-kappaB signaling;cellular protein catabolic process;protein targeting to nucleus;regulation of localization;cytosolic transport;protein complex assembly;regulation of cellular protein metabolic process;macromolecule metabolic process;negative regulation of cellular protein localization;protein localization to organelle;protein localization to nucleus;regulation of cellular localization;macromolecular complex subunit organization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;positive regulation of cellular component biogenesis;positive regulation of cell death;cell death;regulation of cell death;modification-dependent macromolecule catabolic process;protein complex subunit organization;regulation of cellular component biogenesis;negative regulation of protein transport;regulation of cellular protein localization;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;proteolysis involved in cellular protein catabolic process;organic substance transport;positive regulation of programmed cell death;protein phosphorylation;protein import;positive regulation of protein complex assembly;apoptotic process;negative regulation of intracellular protein transport;nucleocytoplasmic transport;cellular protein modification process;regulation of phosphorus metabolic process;single-organism transport;single-organism cellular process;cell adhesion;cell communication;catabolic process;macromolecule catabolic process;single-organism localization;cellular localization;primary metabolic process;regulation of protein phosphorylation;regulation of NF-kappaB import into nucleus;NF-kappaB import into nucleus;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process;protein transport;single-organism intracellular transport;single-organism cellular localization;negative regulation of cellular process;positive regulation of cellular process; 5;5;6;4;6;4;3;6;4;5;3;3;6;4;5;4;7;2;5;3;4;4;4;4;4;5;2;2;3;3;6;5;4;3;4;6;7;5;6;4;4;5;7;6;3;7;6;3;4;6;6;5;4;4;5;6;5;5;6;2;5;4;5;4;6;6;3;5;2;3;4;5;5;6;7;4;3;5;5;5;1;2;5;5;6;3;3;4;6;5;2;6;5;8;7;6;7;8;7;7;4;6;4;4;4;3;3;5;2;4;7;3;4;4;4;2;4;5;7;7;6;5;2;4;6;5;5;3;2;4;5;6;5;2;7;6;6;5;3;6;5;5;4;3;6;7;4;4;5;6;3;4;4;4;6;5;3;4;5;6;3;5;6;5;5;7;5;4;6;4;7;6;5;4;3;3;4;3;5;3;3;3;7;6;6;3;5;3;4;5;5;4;3;3; GO:0031975;GO:0031264;GO:0031265;GO:0005783;GO:0016020;GO:0098588;GO:0031967;GO:0005789;GO:0043234;GO:0043231;GO:0042175;GO:0005829;GO:0044428;GO:0044425;GO:0044422;GO:0043229;GO:0044432;GO:0048471;GO:0034098;GO:0012505;GO:0031090;GO:0044446;GO:0043227;GO:0005737;GO:0005634;GO:0005635;GO:0044459;GO:0005622;GO:0044464;GO:0005623;GO:0071944;GO:0044424;GO:0005575;GO:0044444;GO:0043226;GO:0005886;GO:0032991;GO:0098797;GO:0098796; envelope;death-inducing signaling complex;CD95 death-inducing signaling complex;endoplasmic reticulum;membrane;bounding membrane of organelle;organelle envelope;endoplasmic reticulum membrane;protein complex;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;cytosol;nuclear part;membrane part;organelle part;intracellular organelle;endoplasmic reticulum part;perinuclear region of cytoplasm;VCP-NPL4-UFD1 AAA ATPase complex;endomembrane system;organelle membrane;intracellular organelle part;membrane-bounded organelle;cytoplasm;nucleus;nuclear envelope;plasma membrane part;intracellular;cell part;cell;cell periphery;intracellular part;cellular_component;cytoplasmic part;organelle;plasma membrane;macromolecular complex;plasma membrane protein complex;membrane protein complex; 3;5;6;4;2;4;4;3;3;4;3;5;4;2;2;3;4;5;4;3;3;3;3;4;5;4;3;3;2;2;3;3;1;4;2;3;2;4;3; GO:0019901;GO:0032182;GO:0098772;GO:0031625;GO:0043130;GO:0031072;GO:0003674;GO:0005488;GO:0019887;GO:0019899;GO:0008134;GO:0005515;GO:0044389;GO:0019207;GO:0030234;GO:0051059;GO:0019900; protein kinase binding;ubiquitin-like protein binding;molecular function regulator;ubiquitin protein ligase binding;ubiquitin binding;heat shock protein binding;molecular_function;binding;protein kinase regulator activity;enzyme binding;transcription factor binding;protein binding;ubiquitin-like protein ligase binding;kinase regulator activity;enzyme regulator activity;NF-kappaB binding;kinase binding; 6;4;2;6;5;4;1;2;5;4;4;3;5;4;3;5;5; K20703 IPR001012;IPR033043;IPR006577;IPR012336;IPR029071; UBX domain;FAS-associated factor 1, UBX domain;UAS;Thioredoxin-like fold;Ubiquitin-related domain; cytosol, nucleus Hs5901948 1350.0 T [T] Signal transduction mechanisms; Q9UNN4 TFIIA-alpha and beta-like factor OS=Homo sapiens OX=9606 GN=GTF2A1L PE=1 SV=2 - [TF2AY_HUMAN] 1.092 1.072 0.474 1.725 0.906 1.582 1.018656716 nan 1.90397351 nan 0.442164179 nan 1.746136865 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0003008;GO:0060255;GO:2001141;GO:0046483;GO:0034641;GO:0019438;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050890;GO:0006355;GO:0010556;GO:0006351;GO:0006352;GO:0032774;GO:0044249;GO:0034645;GO:0006139;GO:0006367;GO:0032501;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:0051252;GO:0043170;GO:0031326;GO:0031323;GO:0090304;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0044238;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;system process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;cellular nitrogen compound metabolic process;aromatic compound biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;cognition;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;RNA biosynthetic process;cellular biosynthetic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;transcription initiation from RNA polymerase II promoter;multicellular organismal process;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of RNA metabolic process;macromolecule metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process; 4;3;5;4;3;4;6;4;4;5;3;7;4;4;2;7;5;4;3;1;2;5;5;5;5;6;5;6;7;6;4;5;4;8;2;4;2;4;7;5;4;5;4;5;6;2;3;5;5;5;3;5;4;3;3; GO:0031974;GO:0016591;GO:0030880;GO:0031981;GO:0005672;GO:0044798;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0005667;GO:0044424;GO:0044422;GO:0000428;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0055029;GO:0044446;GO:0090575;GO:0005737;GO:0005634;GO:0044451;GO:0061695;GO:0044464;GO:0005623;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;DNA-directed RNA polymerase II, holoenzyme;RNA polymerase complex;nuclear lumen;transcription factor TFIIA complex;nuclear transcription factor complex;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;transcription factor complex;intracellular part;organelle part;DNA-directed RNA polymerase complex;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;nuclear DNA-directed RNA polymerase complex;intracellular organelle part;RNA polymerase II transcription factor complex;cytoplasm;nucleus;nucleoplasm part;transferase complex, transferring phosphorus-containing groups;cell part;cell;macromolecular complex;cellular_component;intracellular organelle lumen; 2;6;4;5;6;5;4;5;3;4;3;4;4;3;2;5;3;3;3;2;5;5;3;6;4;5;5;6;2;2;2;1;4; GO:1901363;GO:0003713;GO:0003712;GO:0000988;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0097159; heterocyclic compound binding;transcription coactivator activity;transcription cofactor activity;transcription factor activity, protein binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;organic cyclic compound binding; 3;5;4;2;1;2;4;5;3;3; K03122 map03022;map05203; Basal transcription factors;Viral carcinogenesis; IPR009088;IPR009083;IPR004855; Transcription factor IIA, beta-barrel;Transcription factor IIA, helical;Transcription factor IIA, alpha/beta subunit; nucleus Hs5802972 978.0 K [K] Transcription; P55056 Apolipoprotein C-IV OS=Homo sapiens OX=9606 GN=APOC4 PE=1 SV=1 - [APOC4_HUMAN] 1.029 1.059 0.925 0.975 0.898 1.237 0.971671388 0.858451531 1.085746102 0.722341187 0.873465534 0.52437021 1.377505568 0.562369245 GO:0033036;GO:0042592;GO:0019915;GO:0048878;GO:0050789;GO:0044699;GO:0055090;GO:0044710;GO:0010890;GO:0071704;GO:0010884;GO:0065007;GO:0048518;GO:0065008;GO:0070328;GO:0006629;GO:0044238;GO:0055088;GO:0030730;GO:0008150;GO:0008152;GO:0051235;GO:0032879;GO:0010876;GO:0051179;GO:0010883;GO:0010889; macromolecule localization;homeostatic process;lipid storage;chemical homeostasis;regulation of biological process;single-organism process;acylglycerol homeostasis;single-organism metabolic process;positive regulation of sequestering of triglyceride;organic substance metabolic process;positive regulation of lipid storage;biological regulation;positive regulation of biological process;regulation of biological quality;triglyceride homeostasis;lipid metabolic process;primary metabolic process;lipid homeostasis;sequestering of triglyceride;biological_process;metabolic process;maintenance of location;regulation of localization;lipid localization;localization;regulation of lipid storage;regulation of sequestering of triglyceride; 3;4;4;5;2;2;7;3;4;3;3;2;2;3;8;4;3;6;5;1;2;3;3;4;2;4;5; GO:0034358;GO:0034364;GO:0005615;GO:0034361;GO:0032994;GO:0032991;GO:0034385;GO:0005575;GO:0005576;GO:1990777;GO:0044421; plasma lipoprotein particle;high-density lipoprotein particle;extracellular space;very-low-density lipoprotein particle;protein-lipid complex;macromolecular complex;triglyceride-rich lipoprotein particle;cellular_component;extracellular region;lipoprotein particle;extracellular region part; 3;4;3;5;3;2;4;1;2;4;2; GO:0003674;GO:0005319;GO:0005215;GO:0022892; molecular_function;lipid transporter activity;transporter activity;substrate-specific transporter activity; 1;4;2;3; IPR028120; Apolipoprotein C-IV; extracellular P80108 Phosphatidylinositol-glycan-specific phospholipase D OS=Homo sapiens OX=9606 GN=GPLD1 PE=1 SV=3 - [PHLD_HUMAN] 1.061 1.023 1 1.09 1.012 0.835 1.03714565 0.032891848 1.077075099 0.002832083 0.977517107 0.229296561 0.825098814 0.000467461 GO:0035774;GO:0051043;GO:0051044;GO:0051046;GO:0035773;GO:0051049;GO:0046887;GO:0001501;GO:0001503;GO:0044281;GO:0051716;GO:0051047;GO:0046503;GO:0046488;GO:0046486;GO:0010634;GO:0010631;GO:0010632;GO:0034284;GO:0019538;GO:0070633;GO:0009896;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0009891;GO:0010647;GO:0010906;GO:0010907;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0030073;GO:0051345;GO:0002684;GO:0002682;GO:0045913;GO:0070201;GO:0006629;GO:0009308;GO:0009306;GO:0019318;GO:0009888;GO:0043412;GO:0042439;GO:0044723;GO:0009268;GO:0035303;GO:0035304;GO:0035307;GO:0035306;GO:0050714;GO:0071467;GO:0097305;GO:0006576;GO:0097306;GO:0071248;GO:0033619;GO:0071241;GO:0042176;GO:0014070;GO:0051234;GO:0008285;GO:0008286;GO:0008283;GO:0046883;GO:0010675;GO:0010676;GO:0048519;GO:0046889;GO:0044255;GO:0046470;GO:0060341;GO:0042592;GO:0042593;GO:0035690;GO:0008219;GO:0007275;GO:0033993;GO:0043065;GO:0043067;GO:0043068;GO:0019216;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0051270;GO:0010595;GO:0010594;GO:0040017;GO:0010982;GO:0048856;GO:0050995;GO:0050994;GO:0009914;GO:0006796;GO:0006793;GO:0010692;GO:0048523;GO:0048522;GO:0008104;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0044712;GO:0044710;GO:0044711;GO:0071331;GO:0044093;GO:0071333;GO:0002062;GO:0033036;GO:0006664;GO:0051050;GO:0010038;GO:0010035;GO:0010033;GO:0044248;GO:0002429;GO:1900076;GO:0006807;GO:0044242;GO:0044267;GO:0009653;GO:0044262;GO:0002764;GO:0044260;GO:0002768;GO:0001568;GO:0097241;GO:0050790;GO:0009889;GO:0050796;GO:0050794;GO:0051239;GO:0061178;GO:0034014;GO:0051336;GO:0042268;GO:0050896;GO:0034381;GO:0034384;GO:2000145;GO:2000147;GO:0010986;GO:0010984;GO:0006109;GO:0010983;GO:0051246;GO:0006639;GO:0006638;GO:1903530;GO:0070887;GO:1903532;GO:0044699;GO:0032880;GO:0071375;GO:0051240;GO:0001944;GO:0051247;GO:0051179;GO:0031399;GO:0040011;GO:0051272;GO:0071396;GO:0071397;GO:0040012;GO:0090132;GO:0090130;GO:1901135;GO:0042493;GO:0048731;GO:0046890;GO:0001525;GO:0006066;GO:0010867;GO:0010866;GO:0019835;GO:0045937;GO:0010817;GO:0007267;GO:0042221;GO:0008610;GO:0009746;GO:0044238;GO:0005975;GO:0009743;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:0009749;GO:0010694;GO:0090087;GO:0032024;GO:0019220;GO:0019222;GO:0006470;GO:0048584;GO:0048583;GO:0032846;GO:0032844;GO:0072359;GO:0072358;GO:0048869;GO:0045919;GO:0046879;GO:0048513;GO:0048514;GO:0048518;GO:0097006;GO:0042127;GO:0045184;GO:0043534;GO:0043434;GO:0044700;GO:0071214;GO:1901564;GO:0044707;GO:0071322;GO:0010243;GO:0071326;GO:0002376;GO:0005996;GO:0019637;GO:0006928;GO:0051674;GO:0042981;GO:0043542;GO:0002430;GO:0016477;GO:0048646;GO:0006810;GO:0012501;GO:0001678;GO:0006955;GO:0046903;GO:0002757;GO:0031401;GO:1901615;GO:0090209;GO:0090208;GO:0010921;GO:0090207;GO:0030154;GO:0015833;GO:1904951;GO:0006505;GO:0006507;GO:0006509;GO:0006508;GO:0071495;GO:1903509;GO:0006644;GO:0032501;GO:0006643;GO:0006641;GO:0031330;GO:0031331;GO:0009987;GO:0032870;GO:0032879;GO:0050776;GO:0071407;GO:0050778;GO:0071401;GO:0006006;GO:0032869;GO:0045017;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0030335;GO:0030334;GO:0006915;GO:0023061;GO:0061448;GO:0051174;GO:0009058;GO:0051649;GO:0036315;GO:0036314;GO:0009056;GO:0009057;GO:1902578;GO:0051641;GO:1901652;GO:1901653;GO:0080090;GO:0070723;GO:0010604;GO:0045833;GO:0045834;GO:0010896;GO:0010897;GO:0010922;GO:0019725;GO:0060255;GO:0051592;GO:0090276;GO:0090277;GO:0030162;GO:0030163;GO:0051216;GO:0048870;GO:0048878;GO:0019433;GO:0019432;GO:0032940;GO:1901576;GO:1901575;GO:0050708;GO:0016042;GO:0065007;GO:0065009;GO:0065008;GO:0002040;GO:0002042;GO:0009719;GO:0071277;GO:0036211;GO:0008150;GO:0008152;GO:1901698;GO:1901699;GO:0045732;GO:0016311;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0023051;GO:0001667;GO:0010646;GO:0043085;GO:0042886;GO:0032270;GO:0046464;GO:0035701;GO:0046463;GO:0046460;GO:0046461;GO:0009628;GO:0044106;GO:0055082;GO:0032268;GO:0009725;GO:0043170;GO:0045862;GO:0032502;GO:0006650;GO:0031329;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0010942;GO:0032868;GO:0010941;GO:0071417;GO:0033500;GO:0010562;GO:0007154;GO:0002253;GO:0097164;GO:0015031; positive regulation of insulin secretion involved in cellular response to glucose stimulus;regulation of membrane protein ectodomain proteolysis;positive regulation of membrane protein ectodomain proteolysis;regulation of secretion;insulin secretion involved in cellular response to glucose stimulus;regulation of transport;positive regulation of hormone secretion;skeletal system development;ossification;small molecule metabolic process;cellular response to stimulus;positive regulation of secretion;glycerolipid catabolic process;phosphatidylinositol metabolic process;glycerolipid metabolic process;positive regulation of epithelial cell migration;epithelial cell migration;regulation of epithelial cell migration;response to monosaccharide;protein metabolic process;transepithelial transport;positive regulation of catabolic process;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of cell communication;regulation of glucose metabolic process;positive regulation of glucose metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;positive regulation of hydrolase activity;positive regulation of immune system process;regulation of immune system process;positive regulation of carbohydrate metabolic process;regulation of establishment of protein localization;lipid metabolic process;amine metabolic process;protein secretion;hexose metabolic process;tissue development;macromolecule modification;ethanolamine-containing compound metabolic process;single-organism carbohydrate metabolic process;response to pH;regulation of dephosphorylation;regulation of protein dephosphorylation;positive regulation of protein dephosphorylation;positive regulation of dephosphorylation;positive regulation of protein secretion;cellular response to pH;response to alcohol;cellular biogenic amine metabolic process;cellular response to alcohol;cellular response to metal ion;membrane protein proteolysis;cellular response to inorganic substance;regulation of protein catabolic process;response to organic cyclic compound;establishment of localization;negative regulation of cell proliferation;insulin receptor signaling pathway;cell proliferation;regulation of hormone secretion;regulation of cellular carbohydrate metabolic process;positive regulation of cellular carbohydrate metabolic process;negative regulation of biological process;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;phosphatidylcholine metabolic process;regulation of cellular localization;homeostatic process;glucose homeostasis;cellular response to drug;cell death;multicellular organism development;response to lipid;positive regulation of apoptotic process;regulation of programmed cell death;positive regulation of programmed cell death;regulation of lipid metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;regulation of cellular component movement;positive regulation of endothelial cell migration;regulation of endothelial cell migration;positive regulation of locomotion;regulation of high-density lipoprotein particle clearance;anatomical structure development;negative regulation of lipid catabolic process;regulation of lipid catabolic process;hormone transport;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of alkaline phosphatase activity;negative regulation of cellular process;positive regulation of cellular process;protein localization;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular response to hexose stimulus;positive regulation of molecular function;cellular response to glucose stimulus;chondrocyte differentiation;macromolecule localization;glycolipid metabolic process;positive regulation of transport;response to metal ion;response to inorganic substance;response to organic substance;cellular catabolic process;immune response-activating cell surface receptor signaling pathway;regulation of cellular response to insulin stimulus;nitrogen compound metabolic process;cellular lipid catabolic process;cellular protein metabolic process;anatomical structure morphogenesis;cellular carbohydrate metabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;immune response-regulating cell surface receptor signaling pathway;blood vessel development;hematopoietic stem cell migration to bone marrow;regulation of catalytic activity;regulation of biosynthetic process;regulation of insulin secretion;regulation of cellular process;regulation of multicellular organismal process;regulation of insulin secretion involved in cellular response to glucose stimulus;response to triglyceride;regulation of hydrolase activity;regulation of cytolysis;response to stimulus;plasma lipoprotein particle clearance;high-density lipoprotein particle clearance;regulation of cell motility;positive regulation of cell motility;positive regulation of lipoprotein particle clearance;regulation of lipoprotein particle clearance;regulation of carbohydrate metabolic process;positive regulation of high-density lipoprotein particle clearance;regulation of protein metabolic process;acylglycerol metabolic process;neutral lipid metabolic process;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;single-organism process;regulation of protein localization;cellular response to peptide hormone stimulus;positive regulation of multicellular organismal process;vasculature development;positive regulation of protein metabolic process;localization;regulation of protein modification process;locomotion;positive regulation of cellular component movement;cellular response to lipid;cellular response to cholesterol;regulation of locomotion;epithelium migration;tissue migration;carbohydrate derivative metabolic process;response to drug;system development;regulation of lipid biosynthetic process;angiogenesis;alcohol metabolic process;positive regulation of triglyceride biosynthetic process;regulation of triglyceride biosynthetic process;cytolysis;positive regulation of phosphate metabolic process;regulation of hormone levels;cell-cell signaling;response to chemical;lipid biosynthetic process;response to hexose;primary metabolic process;carbohydrate metabolic process;response to carbohydrate;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;response to glucose;positive regulation of alkaline phosphatase activity;regulation of peptide transport;positive regulation of insulin secretion;regulation of phosphate metabolic process;regulation of metabolic process;protein dephosphorylation;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of homeostatic process;regulation of homeostatic process;circulatory system development;cardiovascular system development;cellular developmental process;positive regulation of cytolysis;hormone secretion;animal organ development;blood vessel morphogenesis;positive regulation of biological process;regulation of plasma lipoprotein particle levels;regulation of cell proliferation;establishment of protein localization;blood vessel endothelial cell migration;response to peptide hormone;single organism signaling;cellular response to abiotic stimulus;organonitrogen compound metabolic process;single-multicellular organism process;cellular response to carbohydrate stimulus;response to organonitrogen compound;cellular response to monosaccharide stimulus;immune system process;monosaccharide metabolic process;organophosphate metabolic process;movement of cell or subcellular component;localization of cell;regulation of apoptotic process;endothelial cell migration;complement receptor mediated signaling pathway;cell migration;anatomical structure formation involved in morphogenesis;transport;programmed cell death;cellular glucose homeostasis;immune response;secretion;immune response-activating signal transduction;positive regulation of protein modification process;organic hydroxy compound metabolic process;negative regulation of triglyceride metabolic process;positive regulation of triglyceride metabolic process;regulation of phosphatase activity;regulation of triglyceride metabolic process;cell differentiation;peptide transport;positive regulation of establishment of protein localization;GPI anchor metabolic process;GPI anchor release;membrane protein ectodomain proteolysis;proteolysis;cellular response to endogenous stimulus;liposaccharide metabolic process;phospholipid metabolic process;multicellular organismal process;membrane lipid metabolic process;triglyceride metabolic process;negative regulation of cellular catabolic process;positive regulation of cellular catabolic process;cellular process;cellular response to hormone stimulus;regulation of localization;regulation of immune response;cellular response to organic cyclic compound;positive regulation of immune response;cellular response to triglyceride;glucose metabolic process;cellular response to insulin stimulus;glycerolipid biosynthetic process;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;positive regulation of cell migration;regulation of cell migration;apoptotic process;signal release;connective tissue development;regulation of phosphorus metabolic process;biosynthetic process;establishment of localization in cell;cellular response to sterol;response to sterol;catabolic process;macromolecule catabolic process;single-organism localization;cellular localization;response to peptide;cellular response to peptide;regulation of primary metabolic process;response to cholesterol;positive regulation of macromolecule metabolic process;negative regulation of lipid metabolic process;positive regulation of lipid metabolic process;regulation of triglyceride catabolic process;negative regulation of triglyceride catabolic process;positive regulation of phosphatase activity;cellular homeostasis;regulation of macromolecule metabolic process;response to calcium ion;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;regulation of proteolysis;protein catabolic process;cartilage development;cell motility;chemical homeostasis;triglyceride catabolic process;triglyceride biosynthetic process;secretion by cell;organic substance biosynthetic process;organic substance catabolic process;regulation of protein secretion;lipid catabolic process;biological regulation;regulation of molecular function;regulation of biological quality;sprouting angiogenesis;cell migration involved in sprouting angiogenesis;response to endogenous stimulus;cellular response to calcium ion;protein modification process;biological_process;metabolic process;response to nitrogen compound;cellular response to nitrogen compound;positive regulation of protein catabolic process;dephosphorylation;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of signaling;ameboidal-type cell migration;regulation of cell communication;positive regulation of catalytic activity;amide transport;positive regulation of cellular protein metabolic process;acylglycerol catabolic process;hematopoietic stem cell migration;acylglycerol biosynthetic process;neutral lipid biosynthetic process;neutral lipid catabolic process;response to abiotic stimulus;cellular amine metabolic process;cellular chemical homeostasis;regulation of cellular protein metabolic process;response to hormone;macromolecule metabolic process;positive regulation of proteolysis;developmental process;glycerophospholipid metabolic process;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of cell death;response to insulin;regulation of cell death;cellular response to organonitrogen compound;carbohydrate homeostasis;positive regulation of phosphorus metabolic process;cell communication;activation of immune response;ammonium ion metabolic process;protein transport; 4;6;6;5;5;4;4;5;4;4;3;4;6;7;5;4;6;4;6;4;5;4;4;4;3;3;4;4;6;6;4;5;2;7;6;6;3;3;4;5;4;5;5;6;4;5;4;4;4;7;7;7;7;5;5;5;6;6;6;6;5;5;5;3;4;8;3;4;5;5;2;5;4;5;4;4;7;5;4;4;5;6;5;5;5;6;3;4;3;4;5;4;5;5;3;5;3;5;5;5;5;4;7;3;3;4;4;5;6;7;4;3;4;8;4;7;6;3;6;3;5;4;4;4;5;4;3;5;5;3;4;5;4;6;4;6;4;4;6;3;3;4;5;5;4;2;4;5;4;4;4;4;5;5;5;6;5;5;4;4;2;4;6;3;5;5;2;6;2;4;6;8;3;5;4;4;4;4;5;4;5;6;6;3;6;4;4;3;5;7;3;4;5;6;6;5;3;8;8;5;6;6;3;7;3;3;3;3;5;5;4;4;6;4;4;2;3;4;4;8;5;3;4;4;3;6;4;7;2;5;4;4;3;6;7;6;4;3;4;5;6;3;5;4;6;4;5;5;6;5;5;6;3;7;8;7;5;4;5;5;2;5;7;5;5;2;5;3;4;6;4;6;7;7;5;5;3;5;5;5;5;6;5;5;5;3;4;7;6;3;5;3;3;5;6;4;7;4;4;4;6;6;7;4;4;6;5;5;6;5;5;3;5;8;7;4;4;4;6;5;2;3;3;5;6;3;7;5;1;2;4;5;5;6;3;4;4;2;3;5;4;5;5;5;7;5;6;5;6;3;5;5;5;4;4;6;2;6;5;5;5;4;4;4;4;6;4;5;6;5;4;3;4;5; GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0070062;GO:0005615;GO:0005764;GO:0005765;GO:0016020;GO:0098588;GO:0043230;GO:0043231;GO:0044437;GO:0031090;GO:0043227;GO:0005773;GO:0005774;GO:0098852;GO:0043229;GO:0005622;GO:0043226;GO:0031982;GO:0044446;GO:0044444;GO:0031012;GO:0005737;GO:0098805;GO:0000323;GO:0005623;GO:1903561;GO:0005575;GO:0005576;GO:0005578; intracellular part;extracellular region part;organelle part;cell part;extracellular exosome;extracellular space;lysosome;lysosomal membrane;membrane;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;vacuolar part;organelle membrane;membrane-bounded organelle;vacuole;vacuolar membrane;lytic vacuole membrane;intracellular organelle;intracellular;organelle;vesicle;intracellular organelle part;cytoplasmic part;extracellular matrix;cytoplasm;whole membrane;lytic vacuole;cell;extracellular vesicle;cellular_component;extracellular region;proteinaceous extracellular matrix; 3;2;2;2;4;3;7;6;2;4;3;4;4;3;3;5;4;5;3;3;2;4;3;4;2;4;3;6;2;3;1;2;3; GO:0098772;GO:0004620;GO:0004621;GO:0016787;GO:0016788;GO:0016298;GO:0008081;GO:0004630;GO:0017080;GO:0016247;GO:0003674;GO:0003824;GO:0042578; molecular function regulator;phospholipase activity;glycosylphosphatidylinositol phospholipase D activity;hydrolase activity;hydrolase activity, acting on ester bonds;lipase activity;phosphoric diester hydrolase activity;phospholipase D activity;sodium channel regulator activity;channel regulator activity;molecular_function;catalytic activity;phosphoric ester hydrolase activity; 2;6;8;3;4;5;6;7;4;3;1;2;5; K01127 map00563; Glycosylphosphatidylinositol(GPI)-anchor biosynthesis; IPR013517;IPR013519;IPR029002;IPR001028; FG-GAP repeat;Integrin alpha beta-propellor;Phospholipase C/D;Glycoprotein phospholipase D; extracellular Hs20555902 1734.0 W [W] Extracellular structures; Q8NBP0 Tetratricopeptide repeat protein 13 OS=Homo sapiens OX=9606 GN=TTC13 PE=2 SV=3 - [TTC13_HUMAN] 0.976 1.165 1.035 0.957 1.193 0.502 0.83776824 0.001257388 0.80217938 0.040880239 0.888412017 0.029418223 0.42078793 0.000235345 IPR001440;IPR019734;IPR013026;IPR011990; Tetratricopeptide repeat 1;Tetratricopeptide repeat;Tetratricopeptide repeat-containing domain;Tetratricopeptide-like helical domain; extracellular 428319183 117.0 R [R] General function prediction only; COG0457 Tetratricopeptide (TPR) repeat A0A0B4J1X5 Immunoglobulin heavy variable 3-74 OS=Homo sapiens OX=9606 GN=IGHV3-74 PE=3 SV=1 - [HV374_HUMAN] 1.211 0.875 0.888 0.98 0.987 1.889 1.384 4.72E-08 0.992907801 0.633390023 1.014857143 0.215932781 1.913880446 7.62E-13 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q8NBP7 Proprotein convertase subtilisin/kexin type 9 OS=Homo sapiens OX=9606 GN=PCSK9 PE=1 SV=3 - [PCSK9_HUMAN] 1.003 0.978 1.025 1.051 0.823 1.929 1.025562372 0.857431016 1.277035237 0.024205714 1.04805726 0.686702494 2.343863913 0.092706131 GO:0034381;GO:0080090;GO:0019222;GO:0051049;GO:0048583;GO:0098660;GO:0016485;GO:0010766;GO:0043523;GO:0046486;GO:0007165;GO:0034765;GO:0048260;GO:0030100;GO:1901360;GO:0009267;GO:0051716;GO:0010605;GO:0010604;GO:0009966;GO:0048869;GO:1901216;GO:0071310;GO:0010033;GO:0048513;GO:0044092;GO:0048518;GO:0048519;GO:0034766;GO:0016192;GO:0035725;GO:1902305;GO:0006638;GO:0051051;GO:0060255;GO:0071496;GO:0032412;GO:0032413;GO:1902652;GO:0042221;GO:0030163;GO:0043434;GO:0051128;GO:0065009;GO:0044700;GO:0031668;GO:0031669;GO:0044707;GO:0006898;GO:0019538;GO:0010243;GO:0001822;GO:0048878;GO:0002090;GO:0033554;GO:0001919;GO:0044281;GO:0009896;GO:0009894;GO:0009892;GO:0009893;GO:0032799;GO:1904062;GO:0031667;GO:0042157;GO:0043170;GO:0050789;GO:0009605;GO:0044267;GO:1901575;GO:0044265;GO:0030182;GO:0044260;GO:0070997;GO:0051050;GO:0016043;GO:0009719;GO:0098662;GO:0070887;GO:0065007;GO:0071840;GO:2000649;GO:2000646;GO:0019637;GO:2000644;GO:0044255;GO:0051130;GO:2000272;GO:1902306;GO:0006629;GO:0006812;GO:0006811;GO:0006810;GO:0044710;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0097006;GO:0042632;GO:1901214;GO:0051234;GO:0031623;GO:0010959;GO:0006897;GO:0046907;GO:0012501;GO:0016540;GO:0050896;GO:1901699;GO:0044765;GO:0043068;GO:0034762;GO:0010988;GO:0010984;GO:0010985;GO:2000650;GO:0032805;GO:0032803;GO:0032802;GO:0032801;GO:0048259;GO:0043525;GO:0006639;GO:0030154;GO:1901615;GO:0044248;GO:0023057;GO:0042176;GO:0023052;GO:0007041;GO:0023051;GO:0032410;GO:0010646;GO:0022008;GO:0044699;GO:0071375;GO:0034763;GO:0061008;GO:0051246;GO:0051247;GO:0051179;GO:0032409;GO:0032270;GO:0006508;GO:0015672;GO:0002028;GO:0032502;GO:0006644;GO:0032501;GO:1901701;GO:0031331;GO:0009987;GO:0060627;GO:0055088;GO:0043271;GO:0032870;GO:0030001;GO:0001655;GO:0044257;GO:0072001;GO:0032879;GO:0055085;GO:0008202;GO:0008203;GO:0032268;GO:0051241;GO:0007034;GO:0009725;GO:0034383;GO:1904063;GO:0051239;GO:0065008;GO:0022898;GO:0048731;GO:0048732;GO:1901698;GO:0071495;GO:0009991;GO:0031329;GO:0031325;GO:0031324;GO:0031323;GO:0010989;GO:0042592;GO:0010942;GO:0016125;GO:0001889;GO:0042594;GO:0032869;GO:0032868;GO:0008219;GO:0010941;GO:0007275;GO:0034220;GO:0006066;GO:0045732;GO:0042981;GO:0071417;GO:0006641;GO:0006814;GO:0043065;GO:0071704;GO:0043067;GO:0043269;GO:0001920;GO:0010469;GO:1903364;GO:1903362;GO:0006915;GO:0010467;GO:0051604;GO:0044767;GO:0051402;GO:0044763;GO:0002092;GO:0051649;GO:0007154;GO:0001881;GO:0009056;GO:0009057;GO:1902578;GO:0051641;GO:1901700;GO:0044238;GO:0048699;GO:0098655;GO:0007399;GO:0048856;GO:0044237;GO:0006796;GO:1901652;GO:1901653;GO:0006793;GO:0055092;GO:1902582;GO:0045807;GO:0043112;GO:0048523;GO:0048522; plasma lipoprotein particle clearance;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;regulation of response to stimulus;inorganic ion transmembrane transport;protein processing;negative regulation of sodium ion transport;regulation of neuron apoptotic process;glycerolipid metabolic process;signal transduction;regulation of ion transmembrane transport;positive regulation of receptor-mediated endocytosis;regulation of endocytosis;organic cyclic compound metabolic process;cellular response to starvation;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;regulation of signal transduction;cellular developmental process;positive regulation of neuron death;cellular response to organic substance;response to organic substance;animal organ development;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;negative regulation of ion transmembrane transport;vesicle-mediated transport;sodium ion transmembrane transport;regulation of sodium ion transmembrane transport;neutral lipid metabolic process;negative regulation of transport;regulation of macromolecule metabolic process;cellular response to external stimulus;regulation of ion transmembrane transporter activity;negative regulation of ion transmembrane transporter activity;secondary alcohol metabolic process;response to chemical;protein catabolic process;response to peptide hormone;regulation of cellular component organization;regulation of molecular function;single organism signaling;cellular response to extracellular stimulus;cellular response to nutrient levels;single-multicellular organism process;receptor-mediated endocytosis;protein metabolic process;response to organonitrogen compound;kidney development;chemical homeostasis;regulation of receptor internalization;cellular response to stress;regulation of receptor recycling;small molecule metabolic process;positive regulation of catabolic process;regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;low-density lipoprotein receptor particle metabolic process;regulation of cation transmembrane transport;response to nutrient levels;lipoprotein metabolic process;macromolecule metabolic process;regulation of biological process;response to external stimulus;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;neuron differentiation;cellular macromolecule metabolic process;neuron death;positive regulation of transport;cellular component organization;response to endogenous stimulus;inorganic cation transmembrane transport;cellular response to chemical stimulus;biological regulation;cellular component organization or biogenesis;regulation of sodium ion transmembrane transporter activity;positive regulation of receptor catabolic process;organophosphate metabolic process;regulation of receptor catabolic process;cellular lipid metabolic process;positive regulation of cellular component organization;negative regulation of receptor activity;negative regulation of sodium ion transmembrane transport;lipid metabolic process;cation transport;ion transport;transport;single-organism metabolic process;regulation of cellular process;response to stress;biological_process;metabolic process;regulation of plasma lipoprotein particle levels;cholesterol homeostasis;regulation of neuron death;establishment of localization;receptor internalization;regulation of metal ion transport;endocytosis;intracellular transport;programmed cell death;protein autoprocessing;response to stimulus;cellular response to nitrogen compound;single-organism transport;positive regulation of programmed cell death;regulation of transmembrane transport;regulation of low-density lipoprotein particle clearance;regulation of lipoprotein particle clearance;negative regulation of lipoprotein particle clearance;negative regulation of sodium ion transmembrane transporter activity;positive regulation of low-density lipoprotein particle receptor catabolic process;regulation of low-density lipoprotein particle receptor catabolic process;low-density lipoprotein particle receptor catabolic process;receptor catabolic process;regulation of receptor-mediated endocytosis;positive regulation of neuron apoptotic process;acylglycerol metabolic process;cell differentiation;organic hydroxy compound metabolic process;cellular catabolic process;negative regulation of signaling;regulation of protein catabolic process;signaling;lysosomal transport;regulation of signaling;negative regulation of transporter activity;regulation of cell communication;neurogenesis;single-organism process;cellular response to peptide hormone stimulus;negative regulation of transmembrane transport;hepaticobiliary system development;regulation of protein metabolic process;positive regulation of protein metabolic process;localization;regulation of transporter activity;positive regulation of cellular protein metabolic process;proteolysis;monovalent inorganic cation transport;regulation of sodium ion transport;developmental process;phospholipid metabolic process;multicellular organismal process;cellular response to oxygen-containing compound;positive regulation of cellular catabolic process;cellular process;regulation of vesicle-mediated transport;lipid homeostasis;negative regulation of ion transport;cellular response to hormone stimulus;metal ion transport;urogenital system development;cellular protein catabolic process;renal system development;regulation of localization;transmembrane transport;steroid metabolic process;cholesterol metabolic process;regulation of cellular protein metabolic process;negative regulation of multicellular organismal process;vacuolar transport;response to hormone;low-density lipoprotein particle clearance;negative regulation of cation transmembrane transport;regulation of multicellular organismal process;regulation of biological quality;regulation of transmembrane transporter activity;system development;gland development;response to nitrogen compound;cellular response to endogenous stimulus;response to extracellular stimulus;regulation of cellular catabolic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of low-density lipoprotein particle clearance;homeostatic process;positive regulation of cell death;sterol metabolic process;liver development;response to starvation;cellular response to insulin stimulus;response to insulin;cell death;regulation of cell death;multicellular organism development;ion transmembrane transport;alcohol metabolic process;positive regulation of protein catabolic process;regulation of apoptotic process;cellular response to organonitrogen compound;triglyceride metabolic process;sodium ion transport;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;regulation of ion transport;negative regulation of receptor recycling;regulation of receptor activity;positive regulation of cellular protein catabolic process;regulation of cellular protein catabolic process;apoptotic process;gene expression;protein maturation;single-organism developmental process;neuron apoptotic process;single-organism cellular process;positive regulation of receptor internalization;establishment of localization in cell;cell communication;receptor recycling;catabolic process;macromolecule catabolic process;single-organism localization;cellular localization;response to oxygen-containing compound;primary metabolic process;generation of neurons;cation transmembrane transport;nervous system development;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;response to peptide;cellular response to peptide;phosphorus metabolic process;sterol homeostasis;single-organism intracellular transport;positive regulation of endocytosis;receptor metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;4;3;4;3;6;6;5;6;5;4;5;5;5;4;5;3;4;4;4;4;5;5;4;4;4;2;2;5;5;8;7;5;3;4;4;6;5;6;3;5;5;4;3;3;4;5;3;7;4;4;4;5;5;4;4;4;4;4;3;3;6;6;5;5;4;2;3;5;4;5;6;4;5;3;3;3;7;4;2;2;7;5;4;5;4;4;5;6;4;6;5;4;3;3;3;1;2;3;8;5;3;4;6;6;5;5;7;2;5;4;5;4;5;4;4;6;6;6;6;5;6;6;6;5;4;4;3;5;2;7;3;4;4;6;2;6;4;5;5;5;2;4;5;5;7;7;2;5;2;5;5;2;4;6;4;5;7;5;6;5;3;4;5;7;5;3;6;4;5;6;3;3;5;4;4;4;4;4;5;4;4;4;5;4;4;6;5;4;7;6;4;4;4;5;5;5;6;5;7;8;6;3;5;5;4;4;6;6;6;5;5;3;6;3;5;4;4;4;3;5;3;3;4;3;7;6;5;3;3;5;5;6;4;7;5;4;5;3;3; GO:0016023;GO:0005783;GO:0019898;GO:0000323;GO:0005770;GO:1990667;GO:1990666;GO:0005794;GO:0005791;GO:0030133;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0009897;GO:0016020;GO:0043229;GO:0030134;GO:0043227;GO:0048471;GO:0005886;GO:0012505;GO:0031232;GO:0031982;GO:0005773;GO:0044444;GO:0031988;GO:0097708;GO:0019897;GO:0005737;GO:0031410;GO:0044459;GO:0005764;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098552;GO:0030135;GO:0005615;GO:0043226;GO:0005576;GO:0009986;GO:0032991;GO:0005575;GO:0005768;GO:0005769; cytoplasmic, membrane-bounded vesicle;endoplasmic reticulum;extrinsic component of membrane;lytic vacuole;late endosome;PCSK9-AnxA2 complex;PCSK9-LDLR complex;Golgi apparatus;rough endoplasmic reticulum;transport vesicle;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;external side of plasma membrane;membrane;intracellular organelle;ER to Golgi transport vesicle;membrane-bounded organelle;perinuclear region of cytoplasm;plasma membrane;endomembrane system;extrinsic component of external side of plasma membrane;vesicle;vacuole;cytoplasmic part;membrane-bounded vesicle;intracellular vesicle;extrinsic component of plasma membrane;cytoplasm;cytoplasmic vesicle;plasma membrane part;lysosome;cell part;cell;intracellular;cell periphery;side of membrane;coated vesicle;extracellular space;organelle;extracellular region;cell surface;macromolecular complex;cellular_component;endosome;early endosome; 5;4;3;6;5;4;4;4;5;4;3;4;3;2;2;4;2;3;5;3;5;3;3;5;4;5;4;5;4;4;4;5;3;7;2;2;3;3;3;6;3;2;2;3;2;1;4;5; GO:0004252;GO:0098772;GO:1901363;GO:0044877;GO:0017171;GO:0030169;GO:0034185;GO:0016787;GO:0003674;GO:0003676;GO:0034190;GO:0003824;GO:0005102;GO:0097159;GO:0030545;GO:0030547;GO:0008233;GO:0008236;GO:0043621;GO:0050750;GO:0044822;GO:0008200;GO:0071813;GO:0071814;GO:0003723;GO:0005515;GO:0005488;GO:0004175;GO:0019871;GO:0017080;GO:0016248;GO:0016247;GO:0070325;GO:0070326;GO:0034189;GO:0070011; serine-type endopeptidase activity;molecular function regulator;heterocyclic compound binding;macromolecular complex binding;serine hydrolase activity;low-density lipoprotein particle binding;apolipoprotein binding;hydrolase activity;molecular_function;nucleic acid binding;apolipoprotein receptor binding;catalytic activity;receptor binding;organic cyclic compound binding;receptor regulator activity;receptor inhibitor activity;peptidase activity;serine-type peptidase activity;protein self-association;low-density lipoprotein particle receptor binding;poly(A) RNA binding;ion channel inhibitor activity;lipoprotein particle binding;protein-lipid complex binding;RNA binding;protein binding;binding;endopeptidase activity;sodium channel inhibitor activity;sodium channel regulator activity;channel inhibitor activity;channel regulator activity;lipoprotein particle receptor binding;very-low-density lipoprotein particle receptor binding;very-low-density lipoprotein particle binding;peptidase activity, acting on L-amino acid peptides; 6;2;3;3;4;6;4;3;1;4;5;2;4;3;3;4;4;5;4;6;6;5;5;4;5;3;2;6;5;4;4;3;5;6;4;5; K13050 IPR034193;IPR000209;IPR009020;IPR015500;IPR010259; Proteinase K-like catalytic domain;Peptidase S8/S53 domain;Protease propeptides/proteinase inhibitor I9;Peptidase S8, subtilisin-related;Peptidase S8 propeptide/proteinase inhibitor I9; extracellular 330466470 189.0 O [O] Posttranslational modification, protein turnover, chaperones; COG1404 Serine protease, subtilisin family P41214 Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3 - [EIF2D_HUMAN] 1.044 1.178 0.783 0.914 1.195 0.549 0.886247878 0.6040555 0.764853556 0.056702072 0.664685908 0.372257254 0.459414226 0.000839117 GO:0008104;GO:0071840;GO:0070727;GO:0043043;GO:0033036;GO:0045184;GO:1901564;GO:1901566;GO:0019538;GO:0022607;GO:1903008;GO:0032790;GO:0006807;GO:1901576;GO:0044260;GO:0006886;GO:0016043;GO:0065003;GO:0006810;GO:0008150;GO:0008152;GO:0002190;GO:0051234;GO:0044271;GO:0046907;GO:0002192;GO:0022411;GO:0006518;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0022618;GO:0022613;GO:0002183;GO:0009987;GO:0002181;GO:0043604;GO:0043603;GO:0043170;GO:0043933;GO:0034622;GO:0032984;GO:0032988;GO:0071704;GO:0010467;GO:0071702;GO:0044267;GO:0034613;GO:0071826;GO:0009058;GO:0009059;GO:0044763;GO:0051649;GO:0001731;GO:0051179;GO:0051641;GO:0006996;GO:0044238;GO:0044237;GO:1902589;GO:0044085;GO:0015031;GO:0006413;GO:0006412; protein localization;cellular component organization or biogenesis;cellular macromolecule localization;peptide biosynthetic process;macromolecule localization;establishment of protein localization;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular component assembly;organelle disassembly;ribosome disassembly;nitrogen compound metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;intracellular protein transport;cellular component organization;macromolecular complex assembly;transport;biological_process;metabolic process;cap-independent translational initiation;establishment of localization;cellular nitrogen compound biosynthetic process;intracellular transport;IRES-dependent translational initiation;cellular component disassembly;peptide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;cytoplasmic translational initiation;cellular process;cytoplasmic translation;amide biosynthetic process;cellular amide metabolic process;macromolecule metabolic process;macromolecular complex subunit organization;cellular macromolecular complex assembly;macromolecular complex disassembly;ribonucleoprotein complex disassembly;organic substance metabolic process;gene expression;organic substance transport;cellular protein metabolic process;cellular protein localization;ribonucleoprotein complex subunit organization;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;formation of translation preinitiation complex;localization;cellular localization;organelle organization;primary metabolic process;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;protein transport;translational initiation;translation; 4;2;4;6;3;4;4;5;4;4;5;6;3;4;4;6;3;5;4;1;2;6;3;5;5;7;4;5;4;4;5;2;5;4;5;2;7;6;5;4;4;6;5;6;3;5;5;5;5;5;3;5;3;4;5;2;3;4;3;3;4;3;5;4;6; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasm;nucleus;cell part;cell;cellular_component; 4;3;3;3;3;2;4;5;2;2;1; GO:0060089;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0003743;GO:0003723;GO:0004872;GO:0008135; molecular transducer activity;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;translation initiation factor activity;RNA binding;receptor activity;translation factor activity, RNA binding; 2;3;1;2;4;3;7;5;3;6; K15027 IPR002478;IPR015947;IPR001950;IPR003121; PUA domain;PUA-like domain;SUI1 domain;SWIB/MDM2 domain; nucleus Hs11386191 1204.0 J [J] Translation, ribosomal structure and biogenesis; O94906 Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1 - [PRP6_HUMAN] 0.861 1.092 1.186 0.907 1.138 0.594 0.788461538 0.389245696 0.797012302 0.423715299 1.086080586 0.708348058 0.521968366 0.414987855 GO:0000244;GO:0080090;GO:0019222;GO:1901362;GO:0071840;GO:0000245;GO:0010604;GO:0048518;GO:0033036;GO:1902680;GO:0060255;GO:0006366;GO:2001141;GO:0046483;GO:0000398;GO:0050789;GO:0019438;GO:0022607;GO:0009893;GO:0009891;GO:0006807;GO:0097659;GO:1901576;GO:0000387;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0009059;GO:0016070;GO:0016071;GO:0044271;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0022618;GO:0022613;GO:0008380;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:0045944;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0034622;GO:0010628;GO:0071826;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0006403;GO:0010468;GO:0045935;GO:0019219;GO:0000375;GO:0009058;GO:0000377;GO:0051171;GO:0051173;GO:0051179;GO:0044238;GO:0044237;GO:0044085;GO:0006396;GO:0048522;GO:0006397; spliceosomal tri-snRNP complex assembly;regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;spliceosomal complex assembly;positive regulation of macromolecule metabolic process;positive regulation of biological process;macromolecule localization;positive regulation of RNA biosynthetic process;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of RNA biosynthetic process;heterocycle metabolic process;mRNA splicing, via spliceosome;regulation of biological process;aromatic compound biosynthetic process;cellular component assembly;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;spliceosomal snRNP assembly;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;macromolecule biosynthetic process;RNA metabolic process;mRNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;RNA splicing;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;positive regulation of gene expression;ribonucleoprotein complex subunit organization;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;RNA localization;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;RNA splicing, via transesterification reactions;biosynthetic process;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;localization;primary metabolic process;cellular metabolic process;cellular component biogenesis;RNA processing;positive regulation of cellular process;mRNA processing; 7;4;3;5;2;6;4;2;3;6;4;7;6;4;8;2;5;4;3;4;3;7;4;6;4;3;5;2;4;5;4;3;1;2;5;5;5;6;5;6;5;7;6;6;4;4;5;4;5;4;7;7;2;4;7;6;5;5;4;7;5;4;5;4;4;5;6;5;5;6;3;5;5;4;5;5;5;8;3;9;4;4;2;3;3;3;6;3;7; GO:0031974;GO:0005654;GO:0031981;GO:0016020;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0044464;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0046540;GO:0044446;GO:0005634;GO:0044451;GO:0071013;GO:1990904;GO:0005623;GO:0097525;GO:0097526;GO:0030529;GO:0032991;GO:0030532;GO:0005575;GO:0070013;GO:0005682;GO:0005681; membrane-enclosed lumen;nucleoplasm;nuclear lumen;membrane;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;cell part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;U4/U6 x U5 tri-snRNP complex;intracellular organelle part;nucleus;nucleoplasm part;catalytic step 2 spliceosome;ribonucleoprotein complex;cell;spliceosomal snRNP complex;spliceosomal tri-snRNP complex;intracellular ribonucleoprotein complex;macromolecular complex;small nuclear ribonucleoprotein complex;cellular_component;intracellular organelle lumen;U5 snRNP;spliceosomal complex; 2;5;5;2;4;3;4;3;2;2;3;3;3;2;7;6;8;3;5;5;6;3;2;6;7;4;2;5;1;4;7;5; GO:0050681;GO:1901363;GO:0003713;GO:0003712;GO:0003674;GO:0005488;GO:0003676;GO:0000989;GO:0000988;GO:0043021;GO:0035258;GO:0035257;GO:0097159;GO:0051427;GO:0003723;GO:0005515;GO:0044877;GO:0005102;GO:0044822; androgen receptor binding;heterocyclic compound binding;transcription coactivator activity;transcription cofactor activity;molecular_function;binding;nucleic acid binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;ribonucleoprotein complex binding;steroid hormone receptor binding;nuclear hormone receptor binding;organic cyclic compound binding;hormone receptor binding;RNA binding;protein binding;macromolecular complex binding;receptor binding;poly(A) RNA binding; 8;3;5;4;1;2;4;3;2;4;7;6;3;5;5;3;3;4;6; K12855 map03040; Spliceosome; IPR019734;IPR010491;IPR003107;IPR011990;IPR013026;IPR027108; Tetratricopeptide repeat;PRP1 splicing factor, N-terminal;HAT (Half-A-TPR) repeat;Tetratricopeptide-like helical domain;Tetratricopeptide repeat-containing domain;Pre-mRNA-processing factor 6/Prp1/STA1; cytosol Hs6912732 1938.0 A [A] RNA processing and modification; P98160 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens OX=9606 GN=HSPG2 PE=1 SV=4 - [PGBM_HUMAN] 0.741 0.56 2.172 0.65 0.643 1.05 1.323214286 0.264500934 1.01088647 0.449551255 3.878571429 0.001538313 1.632970451 0.111661894 GO:0006775;GO:0072359;GO:0072358;GO:0044281;GO:0071840;GO:0044710;GO:0048514;GO:0016101;GO:0006766;GO:0007603;GO:0007602;GO:0043436;GO:1901565;GO:0044700;GO:1901564;GO:0044707;GO:0019538;GO:0050789;GO:0030198;GO:0023052;GO:0007165;GO:0030204;GO:0030203;GO:0006807;GO:0044267;GO:1901575;GO:0044260;GO:0001568;GO:0016043;GO:0048646;GO:0006023;GO:0006629;GO:0051716;GO:0050794;GO:0044711;GO:0008150;GO:0008152;GO:0051606;GO:0050896;GO:0050654;GO:0006029;GO:0006022;GO:0022411;GO:0006026;GO:0006027;GO:0006024;GO:0009314;GO:0009416;GO:0009653;GO:1901566;GO:0044699;GO:0001944;GO:0022617;GO:0032502;GO:0032501;GO:0009628;GO:0006721;GO:0006720;GO:0009987;GO:0044255;GO:0006082;GO:1901137;GO:1901136;GO:1901135;GO:0043170;GO:0048731;GO:0042157;GO:1903510;GO:0001525;GO:0009100;GO:0007275;GO:0001523;GO:0071704;GO:0043062;GO:0009605;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:1901576;GO:0065007;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0007154;GO:0009056;GO:0009057;GO:0044238;GO:0005975;GO:0048856;GO:0044237;GO:0006790; fat-soluble vitamin metabolic process;circulatory system development;cardiovascular system development;small molecule metabolic process;cellular component organization or biogenesis;single-organism metabolic process;blood vessel morphogenesis;diterpenoid metabolic process;vitamin metabolic process;phototransduction, visible light;phototransduction;oxoacid metabolic process;organonitrogen compound catabolic process;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;regulation of biological process;extracellular matrix organization;signaling;signal transduction;chondroitin sulfate metabolic process;glycosaminoglycan metabolic process;nitrogen compound metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;blood vessel development;cellular component organization;anatomical structure formation involved in morphogenesis;aminoglycan biosynthetic process;lipid metabolic process;cellular response to stimulus;regulation of cellular process;single-organism biosynthetic process;biological_process;metabolic process;detection of stimulus;response to stimulus;chondroitin sulfate proteoglycan metabolic process;proteoglycan metabolic process;aminoglycan metabolic process;cellular component disassembly;aminoglycan catabolic process;glycosaminoglycan catabolic process;glycosaminoglycan biosynthetic process;response to radiation;response to light stimulus;anatomical structure morphogenesis;organonitrogen compound biosynthetic process;single-organism process;vasculature development;extracellular matrix disassembly;developmental process;multicellular organismal process;response to abiotic stimulus;terpenoid metabolic process;isoprenoid metabolic process;cellular process;cellular lipid metabolic process;organic acid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;macromolecule metabolic process;system development;lipoprotein metabolic process;mucopolysaccharide metabolic process;angiogenesis;glycoprotein metabolic process;multicellular organism development;retinoid metabolic process;organic substance metabolic process;extracellular structure organization;response to external stimulus;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;organic substance biosynthetic process;biological regulation;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cell communication;catabolic process;macromolecule catabolic process;primary metabolic process;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;sulfur compound metabolic process; 6;5;5;4;2;3;4;7;5;6;5;5;5;3;4;3;4;2;5;2;4;5;6;3;5;4;4;4;3;3;5;4;3;3;4;1;2;3;2;5;6;5;4;6;7;6;4;5;3;5;2;5;5;2;2;3;6;5;2;4;4;5;5;4;4;4;5;7;4;5;4;8;3;4;3;4;4;5;6;4;2;3;3;5;3;4;3;5;3;4;3;3;4; GO:0031974;GO:0030055;GO:0043202;GO:0031982;GO:0005773;GO:0016020;GO:0005775;GO:0005794;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044420;GO:0044421;GO:0044422;GO:0043229;GO:0005924;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0044437;GO:0030054;GO:0070161;GO:0012505;GO:0044446;GO:0044444;GO:0000323;GO:0031012;GO:0005737;GO:0005912;GO:0044464;GO:0005623;GO:0071944;GO:0005796;GO:0005764;GO:0005925;GO:0005615;GO:0005886;GO:1903561;GO:0070062;GO:0005604;GO:0005575;GO:0070013;GO:0005576;GO:0005578; membrane-enclosed lumen;cell-substrate junction;lysosomal lumen;vesicle;vacuole;membrane;vacuolar lumen;Golgi apparatus;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular matrix component;extracellular region part;organelle part;intracellular organelle;cell-substrate adherens junction;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;vacuolar part;cell junction;anchoring junction;endomembrane system;intracellular organelle part;cytoplasmic part;lytic vacuole;extracellular matrix;cytoplasm;adherens junction;cell part;cell;cell periphery;Golgi lumen;lysosome;focal adhesion;extracellular space;plasma membrane;extracellular vesicle;extracellular exosome;basement membrane;cellular_component;intracellular organelle lumen;extracellular region;proteinaceous extracellular matrix; 2;3;6;4;5;2;5;4;3;4;3;3;2;2;2;3;4;3;3;2;4;4;2;3;3;3;4;6;2;4;4;2;2;3;5;7;5;3;3;3;4;3;1;4;2;3; GO:0046872;GO:0003674;GO:0005488;GO:0008022;GO:0043169;GO:0043167;GO:0005515; metal ion binding;molecular_function;binding;protein C-terminus binding;cation binding;ion binding;protein binding; 5;1;2;4;4;3;3; K06255 map04512;map05161;map05205; ECM-receptor interaction;Hepatitis B;Proteoglycans in cancer; IPR003599;IPR007110;IPR013783;IPR023415;IPR013098;IPR003598;IPR000082;IPR013106;IPR013320;IPR000034;IPR000742;IPR002172;IPR001881;IPR013032;IPR001791;IPR002049; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Low-density lipoprotein (LDL) receptor class A, conserved site;Immunoglobulin I-set;Immunoglobulin subtype 2;SEA domain;Immunoglobulin V-set domain;Concanavalin A-like lectin/glucanase domain;Laminin IV;EGF-like domain;Low-density lipoprotein (LDL) receptor class A repeat;EGF-like calcium-binding domain;EGF-like, conserved site;Laminin G domain;Laminin EGF domain; extracellular Hs7427517 8894.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9P2W9 Syntaxin-18 OS=Homo sapiens OX=9606 GN=STX18 PE=1 SV=1 - [STX18_HUMAN] 0.782 0.814 1.601 0.756 0.78 2.034 0.960687961 nan 0.969230769 nan 1.966830467 nan 2.607692308 nan GO:0008104;GO:0032388;GO:0051049;GO:0032386;GO:0061025;GO:0061024;GO:0071840;GO:0070727;GO:0010256;GO:0048518;GO:0033036;GO:1902953;GO:0051050;GO:0071702;GO:0045184;GO:0016192;GO:0010638;GO:0022607;GO:1903651;GO:0006888;GO:0006886;GO:0016043;GO:0065007;GO:0044699;GO:0051130;GO:1903649;GO:0006810;GO:0050794;GO:0044802;GO:0051234;GO:0006890;GO:0046907;GO:0008150;GO:0033043;GO:0051128;GO:0060628;GO:0009987;GO:0060627;GO:0032879;GO:0016482;GO:0007030;GO:0060341;GO:1903358;GO:0044087;GO:0007029;GO:0050789;GO:1902115;GO:1902117;GO:0048193;GO:0034613;GO:0044765;GO:0044763;GO:0051649;GO:0070925;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0090158;GO:0044085;GO:0015031;GO:1902582;GO:0044089;GO:0048522; protein localization;positive regulation of intracellular transport;regulation of transport;regulation of intracellular transport;membrane fusion;membrane organization;cellular component organization or biogenesis;cellular macromolecule localization;endomembrane system organization;positive regulation of biological process;macromolecule localization;positive regulation of ER to Golgi vesicle-mediated transport;positive regulation of transport;organic substance transport;establishment of protein localization;vesicle-mediated transport;positive regulation of organelle organization;cellular component assembly;positive regulation of cytoplasmic transport;ER to Golgi vesicle-mediated transport;intracellular protein transport;cellular component organization;biological regulation;single-organism process;positive regulation of cellular component organization;regulation of cytoplasmic transport;transport;regulation of cellular process;single-organism membrane organization;establishment of localization;retrograde vesicle-mediated transport, Golgi to ER;intracellular transport;biological_process;regulation of organelle organization;regulation of cellular component organization;regulation of ER to Golgi vesicle-mediated transport;cellular process;regulation of vesicle-mediated transport;regulation of localization;cytosolic transport;Golgi organization;regulation of cellular localization;regulation of Golgi organization;regulation of cellular component biogenesis;endoplasmic reticulum organization;regulation of biological process;regulation of organelle assembly;positive regulation of organelle assembly;Golgi vesicle transport;cellular protein localization;single-organism transport;single-organism cellular process;establishment of localization in cell;organelle assembly;localization;single-organism localization;cellular localization;organelle organization;endoplasmic reticulum membrane organization;cellular component biogenesis;protein transport;single-organism intracellular transport;positive regulation of cellular component biogenesis;positive regulation of cellular process; 4;4;4;5;5;4;2;4;4;2;3;6;3;5;4;5;5;4;5;7;6;3;2;2;4;6;4;3;4;3;7;5;1;5;4;5;2;4;3;6;5;4;6;3;5;2;4;4;6;5;4;3;4;5;2;3;3;4;5;3;5;5;3;3; GO:0005783;GO:0005789;GO:0016021;GO:0016020;GO:0005794;GO:0098588;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0042175;GO:0031224;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0031201;GO:0032991;GO:0005575;GO:0098796; endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;Golgi apparatus;bounding membrane of organelle;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;intrinsic component of membrane;cytoplasm;organelle membrane;cell part;cell;intracellular;SNARE complex;macromolecular complex;cellular_component;membrane protein complex; 4;3;4;2;4;4;3;4;3;2;2;3;3;2;4;4;3;5;3;4;3;3;4;3;2;2;3;4;2;1;3; GO:0003674;GO:0005488;GO:0005484;GO:0005515; molecular_function;binding;SNAP receptor activity;protein binding; 1;2;4;3; K08492 map04130;map04145; SNARE interactions in vesicular transport;Phagosome; IPR006012;IPR019529; Syntaxin/epimorphin, conserved site;SNARE-complex protein Syntaxin-18, N-terminal; peroxisome Hs8394376 689.0 U [U] Intracellular trafficking, secretion, and vesicular transport; P08519 Apolipoprotein(a) OS=Homo sapiens OX=9606 GN=LPA PE=1 SV=1 - [APOA_HUMAN] 0.895 0.803 1.806 0.946 0.853 0.665 1.114570361 0.43363902 1.109026964 0.102965064 2.249066002 0.015253545 0.779601407 0.842283974 GO:0019222;GO:0003013;GO:0044281;GO:0080090;GO:0044710;GO:0010605;GO:0044092;GO:0048519;GO:0033036;GO:0060255;GO:0030162;GO:0010876;GO:0003008;GO:0016192;GO:0019538;GO:0009892;GO:0050789;GO:0044267;GO:0051346;GO:0044260;GO:0065007;GO:0065009;GO:0050790;GO:0006629;GO:0008015;GO:0006810;GO:0050794;GO:0008150;GO:0008152;GO:0051234;GO:0051336;GO:0006897;GO:0006898;GO:0006869;GO:0043086;GO:0044699;GO:0051248;GO:0051246;GO:0051179;GO:0006508;GO:0032501;GO:0009987;GO:0032269;GO:0032268;GO:0043170;GO:0045861;GO:0042157;GO:0031324;GO:0031323;GO:0071704;GO:0010466;GO:0071702;GO:0052547;GO:0052548;GO:0044765;GO:0010951;GO:1902578;GO:0044238;GO:0044237;GO:0048523; regulation of metabolic process;circulatory system process;small molecule metabolic process;regulation of primary metabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;negative regulation of molecular function;negative regulation of biological process;macromolecule localization;regulation of macromolecule metabolic process;regulation of proteolysis;lipid localization;system process;vesicle-mediated transport;protein metabolic process;negative regulation of metabolic process;regulation of biological process;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;biological regulation;regulation of molecular function;regulation of catalytic activity;lipid metabolic process;blood circulation;transport;regulation of cellular process;biological_process;metabolic process;establishment of localization;regulation of hydrolase activity;endocytosis;receptor-mediated endocytosis;lipid transport;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;localization;proteolysis;multicellular organismal process;cellular process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;macromolecule metabolic process;negative regulation of proteolysis;lipoprotein metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;organic substance metabolic process;negative regulation of peptidase activity;organic substance transport;regulation of peptidase activity;regulation of endopeptidase activity;single-organism transport;negative regulation of endopeptidase activity;single-organism localization;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 3;4;4;4;3;4;4;2;3;4;6;4;3;5;4;3;2;5;6;4;2;3;4;4;5;4;3;1;2;3;5;6;7;5;5;2;5;5;2;5;2;2;5;5;4;6;5;4;4;3;7;5;6;7;4;8;3;3;3;3; GO:0034358;GO:0044421;GO:1990777;GO:0032994;GO:0005615;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;extracellular region part;lipoprotein particle;protein-lipid complex;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;2;4;3;3;2;1;2; GO:0004252;GO:0070011;GO:0098772;GO:0004866;GO:0017171;GO:0097367;GO:0003674;GO:0005488;GO:0030234;GO:0001968;GO:0016787;GO:0003824;GO:0005539;GO:0008233;GO:0043167;GO:0008236;GO:0043168;GO:0004857;GO:0030414;GO:0008201;GO:0005515;GO:0004175;GO:1901681;GO:0061135;GO:0061134;GO:0034185; serine-type endopeptidase activity;peptidase activity, acting on L-amino acid peptides;molecular function regulator;endopeptidase inhibitor activity;serine hydrolase activity;carbohydrate derivative binding;molecular_function;binding;enzyme regulator activity;fibronectin binding;hydrolase activity;catalytic activity;glycosaminoglycan binding;peptidase activity;ion binding;serine-type peptidase activity;anion binding;enzyme inhibitor activity;peptidase inhibitor activity;heparin binding;protein binding;endopeptidase activity;sulfur compound binding;endopeptidase regulator activity;peptidase regulator activity;apolipoprotein binding; 6;5;2;6;4;3;1;2;3;4;3;2;4;4;3;5;4;4;5;4;3;6;3;5;4;4; K09644 IPR001254;IPR018056;IPR009003;IPR000001;IPR001314;IPR013806;IPR033116;IPR018114; Serine proteases, trypsin domain;Kringle, conserved site;Peptidase S1, PA clan;Kringle;Peptidase S1A, chymotrypsin family;Kringle-like fold;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular 159897046 153.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease O15027 Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4 - [SC16A_HUMAN] 0.816 0.934 1.343 0.843 1.094 1.253 0.87366167 nan 0.770566728 nan 1.437901499 nan 1.145338208 nan GO:0008104;GO:0006901;GO:0006900;GO:0006903;GO:0061024;GO:0060322;GO:0051656;GO:0051650;GO:0071840;GO:0044710;GO:0010256;GO:0018193;GO:0048513;GO:0033036;GO:0045184;GO:0051668;GO:0016192;GO:0044707;GO:0019538;GO:0016050;GO:0022607;GO:1901576;GO:0006888;GO:0044260;GO:0048193;GO:0016043;GO:0065003;GO:0006810;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0051234;GO:0090114;GO:0007420;GO:0046907;GO:0044765;GO:0043413;GO:0044802;GO:0018196;GO:0070271;GO:0044249;GO:0021762;GO:0034645;GO:0044699;GO:0007417;GO:0051640;GO:0032502;GO:0032501;GO:1902591;GO:0043687;GO:0009987;GO:1901137;GO:1901135;GO:0043170;GO:0048731;GO:0048208;GO:0043933;GO:0048207;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0007029;GO:0007275;GO:0071704;GO:0071702;GO:0018279;GO:0044267;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051648;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0071822;GO:0007399;GO:0048857;GO:0048856;GO:0044237;GO:1902589;GO:0044085;GO:0030901;GO:0015031;GO:1902582;GO:1902580; protein localization;vesicle coating;membrane budding;vesicle targeting;membrane organization;head development;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;single-organism metabolic process;endomembrane system organization;peptidyl-amino acid modification;animal organ development;macromolecule localization;establishment of protein localization;localization within membrane;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;vesicle organization;cellular component assembly;organic substance biosynthetic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;Golgi vesicle transport;cellular component organization;macromolecular complex assembly;transport;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;COPII-coated vesicle budding;brain development;intracellular transport;single-organism transport;macromolecule glycosylation;single-organism membrane organization;peptidyl-asparagine modification;protein complex biogenesis;cellular biosynthetic process;substantia nigra development;cellular macromolecule biosynthetic process;single-organism process;central nervous system development;organelle localization;developmental process;multicellular organismal process;single-organism membrane budding;post-translational protein modification;cellular process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;system development;COPII vesicle coating;macromolecular complex subunit organization;vesicle targeting, rough ER to cis-Golgi;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;endoplasmic reticulum organization;multicellular organism development;organic substance metabolic process;organic substance transport;protein N-linked glycosylation via asparagine;cellular protein metabolic process;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;vesicle localization;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;protein complex subunit organization;nervous system development;neural nucleus development;anatomical structure development;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;midbrain development;protein transport;single-organism intracellular transport;single-organism cellular localization; 4;6;5;4;4;4;4;5;2;3;4;7;4;3;4;4;5;3;4;5;4;4;7;4;6;3;5;4;5;5;1;2;4;3;5;4;5;4;6;4;8;4;4;5;5;2;5;4;2;2;5;7;2;5;4;4;4;6;4;6;5;6;4;5;5;4;3;5;6;5;5;5;5;6;3;3;5;3;5;4;2;3;3;4;3;4;5;5;4;3;3;4;3;4;5;5;4; GO:0005783;GO:0005789;GO:0016020;GO:0005794;GO:0098588;GO:0043231;GO:0042175;GO:0005829;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;membrane;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;cytosol;intracellular part;membrane part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;cell part;cell;cellular_component; 4;3;2;4;4;4;3;5;3;2;2;3;3;3;2;4;4;3;5;3;4;4;3;2;2;1; K20353 IPR024340;IPR024880;IPR024298; Sec16, central conserved domain;COPII coat assembly protein, Sec16;Ancestral coatomer element 1, Sec16/Sec31; nucleus Hs22046342 3372.0 K [K] Transcription; P06746 DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3 - [DPOLB_HUMAN] 1.161 0.834 1.171 1.06 0.887 1.126 1.392086331 nan 1.195039459 nan 1.404076739 nan 1.269447576 nan GO:0033151;GO:0007165;GO:0033152;GO:1901360;GO:0051716;GO:0048513;GO:0006260;GO:0006261;GO:0006287;GO:0006284;GO:0006281;GO:0035272;GO:0010033;GO:0046483;GO:0044700;GO:0044707;GO:0002376;GO:0002377;GO:0033554;GO:0016445;GO:0016444;GO:0016446;GO:0006290;GO:0006807;GO:0035556;GO:0043170;GO:1901576;GO:0007435;GO:0044260;GO:0007431;GO:0070997;GO:0065007;GO:0002200;GO:0065008;GO:0009887;GO:0044710;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0002520;GO:0002562;GO:0050896;GO:0036296;GO:0051402;GO:0016447;GO:0097305;GO:0006954;GO:0009314;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007154;GO:0009653;GO:0044699;GO:0006139;GO:0010212;GO:0022612;GO:0032502;GO:1901700;GO:0032501;GO:0044238;GO:0009987;GO:0006725;GO:0048872;GO:0006974;GO:0042592;GO:0007568;GO:0008630;GO:0048731;GO:0048732;GO:0097190;GO:0097193;GO:0090304;GO:0008219;GO:0055093;GO:0007275;GO:0012501;GO:0010332;GO:0050789;GO:0071704;GO:0071707;GO:0048536;GO:0048534;GO:0048535;GO:0006915;GO:0044767;GO:0045471;GO:0009058;GO:0009059;GO:0044763;GO:0002440;GO:0042221;GO:0070482;GO:0006310;GO:0009628;GO:0002566;GO:0048856;GO:0044237;GO:0006259; V(D)J recombination;signal transduction;immunoglobulin V(D)J recombination;organic cyclic compound metabolic process;cellular response to stimulus;animal organ development;DNA replication;DNA-dependent DNA replication;base-excision repair, gap-filling;base-excision repair;DNA repair;exocrine system development;response to organic substance;heterocycle metabolic process;single organism signaling;single-multicellular organism process;immune system process;immunoglobulin production;cellular response to stress;somatic diversification of immunoglobulins;somatic cell DNA recombination;somatic hypermutation of immunoglobulin genes;pyrimidine dimer repair;nitrogen compound metabolic process;intracellular signal transduction;macromolecule metabolic process;organic substance biosynthetic process;salivary gland morphogenesis;cellular macromolecule metabolic process;salivary gland development;neuron death;biological regulation;somatic diversification of immune receptors;regulation of biological quality;organ morphogenesis;single-organism metabolic process;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;immune system development;somatic diversification of immune receptors via germline recombination within a single locus;response to stimulus;response to increased oxygen levels;neuron apoptotic process;somatic recombination of immunoglobulin gene segments;response to alcohol;inflammatory response;response to radiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;response to ionizing radiation;gland morphogenesis;developmental process;response to oxygen-containing compound;multicellular organismal process;primary metabolic process;cellular process;cellular aromatic compound metabolic process;homeostasis of number of cells;cellular response to DNA damage stimulus;homeostatic process;aging;intrinsic apoptotic signaling pathway in response to DNA damage;system development;gland development;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;nucleic acid metabolic process;cell death;response to hyperoxia;multicellular organism development;programmed cell death;response to gamma radiation;regulation of biological process;organic substance metabolic process;immunoglobulin heavy chain V-D-J recombination;spleen development;hematopoietic or lymphoid organ development;lymph node development;apoptotic process;single-organism developmental process;response to ethanol;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;production of molecular mediator of immune response;response to chemical;response to oxygen levels;DNA recombination;response to abiotic stimulus;somatic diversification of immune receptors via somatic mutation;anatomical structure development;cellular metabolic process;DNA metabolic process; 5;4;6;4;3;4;6;7;6;5;4;5;4;4;3;3;2;4;4;4;7;5;5;3;5;4;4;6;4;5;5;2;3;3;4;3;3;4;3;1;2;3;4;2;5;6;5;5;5;4;4;4;2;5;4;3;2;4;5;5;2;4;2;3;2;4;5;5;4;4;6;4;4;5;6;5;4;4;4;5;6;2;3;7;5;4;5;6;3;6;3;5;3;3;3;4;6;3;4;3;3;5; GO:0099512;GO:0099513;GO:0031974;GO:0031981;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0043227;GO:0043226;GO:0005856;GO:0005654;GO:0044430;GO:0005876;GO:0044446;GO:0005874;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0005819;GO:0015630;GO:0032991;GO:0005575;GO:0070013; supramolecular fiber;polymeric cytoskeletal fiber;membrane-enclosed lumen;nuclear lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;organelle;cytoskeleton;nucleoplasm;cytoskeletal part;spindle microtubule;intracellular organelle part;microtubule;cytoplasm;nucleus;cell part;cell;intracellular;non-membrane-bounded organelle;spindle;microtubule cytoskeleton;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;2;5;3;4;3;4;3;2;4;3;3;2;5;5;4;5;3;4;4;5;2;2;3;3;5;6;2;1;4; GO:1901363;GO:0016740;GO:0046872;GO:0034061;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043169;GO:0008017;GO:0003824;GO:0016779;GO:0008092;GO:0016772;GO:0044877;GO:0016829;GO:0019899;GO:0043167;GO:0032403;GO:0005515;GO:0097159;GO:0003684;GO:0003887;GO:0015631; heterocyclic compound binding;transferase activity;metal ion binding;DNA polymerase activity;molecular_function;binding;nucleic acid binding;DNA binding;cation binding;microtubule binding;catalytic activity;nucleotidyltransferase activity;cytoskeletal protein binding;transferase activity, transferring phosphorus-containing groups;macromolecular complex binding;lyase activity;enzyme binding;ion binding;protein complex binding;protein binding;organic cyclic compound binding;damaged DNA binding;DNA-directed DNA polymerase activity;tubulin binding; 3;3;5;6;1;2;4;5;4;5;2;5;4;4;3;3;4;3;4;3;3;6;7;5; K02330 map03410;map05166;map05203; Base excision repair;HTLV-I infection;Viral carcinogenesis; IPR022312;IPR018944;IPR029398;IPR003583;IPR002008;IPR019843;IPR002054;IPR028207;IPR010996; DNA polymerase family X;DNA polymerase lambda, fingers domain;DNA polymerase beta, thumb domain;Helix-hairpin-helix DNA-binding motif, class 1;DNA polymerase family X, beta-like;DNA polymerase family X, binding site;DNA-directed DNA polymerase X;DNA polymerase beta, palm domain;DNA polymerase beta-like, N-terminal domain; cytosol Hs4505931 695.0 L [L] Replication, recombination and repair; Q8NFC6 Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2 - [BD1L1_HUMAN] 1.14 0.964 0.957 0.976 1.032 1.368 1.182572614 0.184873104 0.945736434 0.054659877 0.992738589 0.956462545 1.325581395 0.170928633 GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901576;GO:0044699;GO:0006139;GO:0044710;GO:0044260;GO:0071704;GO:0006260;GO:1901360;GO:0031297;GO:0006261;GO:0006281;GO:0009987;GO:0006725;GO:0051716;GO:0006974;GO:0006950;GO:0009059;GO:0008150;GO:0008152;GO:0046483;GO:0045005;GO:0044238;GO:0050896;GO:0009058;GO:0044237;GO:0043170;GO:0033554;GO:0006259;GO:0044763; nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic substance biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;single-organism metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;DNA replication;organic cyclic compound metabolic process;replication fork processing;DNA-dependent DNA replication;DNA repair;cellular process;cellular aromatic compound metabolic process;cellular response to stimulus;cellular response to DNA damage stimulus;response to stress;macromolecule biosynthetic process;biological_process;metabolic process;heterocycle metabolic process;DNA-dependent DNA replication maintenance of fidelity;primary metabolic process;response to stimulus;biosynthetic process;cellular metabolic process;macromolecule metabolic process;cellular response to stress;DNA metabolic process;single-organism cellular process; 5;4;4;3;5;4;2;4;3;4;3;6;4;4;7;4;2;4;3;5;3;5;1;2;4;6;3;2;3;3;4;4;5;3; GO:0031974;GO:0005623;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0005654;GO:0005575;GO:0043229;GO:0044424;GO:0005694;GO:0043231;GO:0043232;GO:0043233;GO:0031981;GO:0044464;GO:0044446;GO:0070013;GO:0043228;GO:0044428;GO:0044422; membrane-enclosed lumen;cell;intracellular;membrane-bounded organelle;organelle;nucleus;nucleoplasm;cellular_component;intracellular organelle;intracellular part;chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear lumen;cell part;intracellular organelle part;intracellular organelle lumen;non-membrane-bounded organelle;nuclear part;organelle part; 2;2;3;3;2;5;5;1;3;3;5;4;4;3;5;2;3;4;3;4;2; GO:0003676;GO:0003674;GO:0003677;GO:1901363;GO:0097159;GO:0005488; nucleic acid binding;molecular_function;DNA binding;heterocyclic compound binding;organic cyclic compound binding;binding; 4;1;5;3;3;2; IPR026955; Biorientation of chromosomes in cell division protein 1-like; nucleus O14514 Adhesion G protein-coupled receptor B1 OS=Homo sapiens OX=9606 GN=ADGRB1 PE=1 SV=2 - [AGRB1_HUMAN] 1.189 1.091 0.778 1.112 1.065 1.048 1.089825848 nan 1.044131455 nan 0.713107241 nan 0.984037559 nan GO:0048468;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0071840;GO:0051716;GO:0048869;GO:0048514;GO:0048518;GO:0048519;GO:0042127;GO:0044700;GO:0044707;GO:0022607;GO:0022603;GO:0031175;GO:0050789;GO:0000904;GO:0000902;GO:0001568;GO:0016043;GO:0065007;GO:0065008;GO:0007186;GO:0048646;GO:0051130;GO:0061564;GO:0050793;GO:0050794;GO:0008150;GO:0051239;GO:0007422;GO:0050896;GO:0051963;GO:0051962;GO:0051960;GO:0051965;GO:0016525;GO:0050808;GO:0050803;GO:0030154;GO:0050807;GO:0051128;GO:0023052;GO:2000181;GO:0009653;GO:0007416;GO:0051240;GO:0051241;GO:0001944;GO:0022610;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0009987;GO:0007409;GO:0048858;GO:0051093;GO:0044699;GO:0051094;GO:1901342;GO:1901343;GO:0048731;GO:0030030;GO:0001525;GO:0007275;GO:0045765;GO:0032989;GO:0048812;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044763;GO:0007155;GO:0007154;GO:0022008;GO:0048699;GO:0032990;GO:0007399;GO:0048856;GO:0044087;GO:0044085;GO:2000026;GO:0044089;GO:0048523;GO:0048522; cell development;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;single organism signaling;single-multicellular organism process;cellular component assembly;regulation of anatomical structure morphogenesis;neuron projection development;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;blood vessel development;cellular component organization;biological regulation;regulation of biological quality;G-protein coupled receptor signaling pathway;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;axon development;regulation of developmental process;regulation of cellular process;biological_process;regulation of multicellular organismal process;peripheral nervous system development;response to stimulus;regulation of synapse assembly;positive regulation of nervous system development;regulation of nervous system development;positive regulation of synapse assembly;negative regulation of angiogenesis;synapse organization;regulation of synapse structure or activity;cell differentiation;regulation of synapse organization;regulation of cellular component organization;signaling;negative regulation of blood vessel morphogenesis;anatomical structure morphogenesis;synapse assembly;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;vasculature development;biological adhesion;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;axonogenesis;cell projection morphogenesis;negative regulation of developmental process;single-organism process;positive regulation of developmental process;regulation of vasculature development;negative regulation of vasculature development;system development;cell projection organization;angiogenesis;multicellular organism development;regulation of angiogenesis;cellular component morphogenesis;neuron projection morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism cellular process;cell adhesion;cell communication;neurogenesis;generation of neurons;cell part morphogenesis;nervous system development;anatomical structure development;regulation of cellular component biogenesis;cellular component biogenesis;regulation of multicellular organismal development;positive regulation of cellular component biogenesis;negative regulation of cellular process;positive regulation of cellular process; 4;5;5;4;5;2;3;4;4;2;2;4;3;3;4;4;5;2;5;5;4;3;2;3;5;3;4;6;3;3;1;3;5;2;4;4;5;4;5;4;4;5;5;4;2;5;3;5;3;3;5;2;2;4;2;3;2;7;5;3;2;3;5;4;4;4;4;4;5;4;6;5;6;6;3;3;3;4;6;7;5;5;3;3;3;4;3;3;3; GO:0005911;GO:0016021;GO:0016020;GO:0043232;GO:0030054;GO:0044424;GO:0044425;GO:0043229;GO:0043228;GO:0031224;GO:0060076;GO:0043226;GO:0031226;GO:0044456;GO:0044459;GO:0098794;GO:0014069;GO:0044464;GO:0005623;GO:0005622;GO:0045202;GO:0099572;GO:0071944;GO:0005887;GO:0005886;GO:0005575; cell-cell junction;integral component of membrane;membrane;intracellular non-membrane-bounded organelle;cell junction;intracellular part;membrane part;intracellular organelle;non-membrane-bounded organelle;intrinsic component of membrane;excitatory synapse;organelle;intrinsic component of plasma membrane;synapse part;plasma membrane part;postsynapse;postsynaptic density;cell part;cell;intracellular;synapse;postsynaptic specialization;cell periphery;integral component of plasma membrane;plasma membrane;cellular_component; 3;4;2;4;2;3;2;3;3;3;3;2;4;2;3;3;4;2;2;3;2;3;3;4;3;1; GO:0060089;GO:0099600;GO:0003674;GO:0004930;GO:0038023;GO:0004872;GO:0004871;GO:0004888; molecular transducer activity;transmembrane receptor activity;molecular_function;G-protein coupled receptor activity;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity; 2;4;1;5;3;3;2;4; K04596 map04115; p53 signaling pathway; IPR017981;IPR032471;IPR008077;IPR000832;IPR000203;IPR000884;IPR001879; GPCR, family 2-like;GAIN domain, N-terminal;GPCR, family 2, brain-specific angiogenesis inhibitor;GPCR, family 2, secretin-like;GPS motif;Thrombospondin type-1 (TSP1) repeat;GPCR, family 2, extracellular hormone receptor domain; plasma membrane Q92673 Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2 - [SORL_HUMAN] 1.398 0.875 0.911 1.02 0.852 1.424 1.597714286 nan 1.197183099 nan 1.041142857 nan 1.671361502 nan GO:0033157;GO:0051049;GO:2001137;GO:0044281;GO:2001135;GO:0032388;GO:0051651;GO:0051716;GO:0000165;GO:0032386;GO:1905049;GO:1905048;GO:0048468;GO:0045859;GO:0042325;GO:0042326;GO:0019538;GO:0009896;GO:0009894;GO:0009892;GO:0009893;GO:0000301;GO:0014812;GO:0051222;GO:0071900;GO:0050789;GO:0032091;GO:0006888;GO:0051346;GO:0006886;GO:0051348;GO:1901360;GO:0070201;GO:0006629;GO:1903649;GO:0006622;GO:0006623;GO:0043412;GO:0009966;GO:0043393;GO:0051129;GO:0051128;GO:1903827;GO:0042176;GO:0050435;GO:1901214;GO:0051234;GO:0060284;GO:0061462;GO:0050896;GO:0060341;GO:0008219;GO:0007275;GO:0060548;GO:0006468;GO:0032527;GO:0006461;GO:0090316;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0010951;GO:0040011;GO:0040012;GO:0048856;GO:0006066;GO:0006796;GO:2000026;GO:0032456;GO:0006793;GO:0032459;GO:0048523;GO:0048522;GO:0008104;GO:0007165;GO:0044710;GO:0070841;GO:0071704;GO:1902771;GO:1902959;GO:0044093;GO:0044092;GO:1902954;GO:1902955;GO:0033036;GO:1902953;GO:0051050;GO:0034205;GO:1902652;GO:1904683;GO:0034067;GO:0006807;GO:0044267;GO:0044260;GO:0070997;GO:0044699;GO:0043408;GO:0050793;GO:0050790;GO:0050794;GO:0051239;GO:0051235;GO:1901215;GO:0051336;GO:0006892;GO:0006891;GO:0006897;GO:0006898;GO:0051338;GO:0051961;GO:0051960;GO:2000145;GO:0006518;GO:0010563;GO:0070271;GO:0072666;GO:0072665;GO:0043407;GO:0043405;GO:0007041;GO:0043409;GO:0032880;GO:0050767;GO:0051248;GO:0051241;GO:0051246;GO:0051247;GO:0050768;GO:0009057;GO:0031399;GO:0016125;GO:0072594;GO:0034249;GO:0034248;GO:0051270;GO:0007034;GO:0033365;GO:0043933;GO:0035556;GO:0051223;GO:0045936;GO:0052548;GO:0051347;GO:0022008;GO:0090083;GO:0044238;GO:0036010;GO:0044237;GO:0090084;GO:0019220;GO:0019222;GO:0048585;GO:0048583;GO:0071840;GO:0009968;GO:0048869;GO:0010721;GO:0048518;GO:0048519;GO:0008203;GO:0006605;GO:0045184;GO:0045185;GO:0016197;GO:0044700;GO:1901564;GO:0016192;GO:0044707;GO:1902947;GO:1902946;GO:1902948;GO:1902003;GO:1902769;GO:0033673;GO:0022607;GO:0051100;GO:0006928;GO:0051674;GO:0042987;GO:0043170;GO:0042982;GO:0045053;GO:0043549;GO:0016477;GO:0006810;GO:1902430;GO:0048731;GO:1902532;GO:1902531;GO:0010604;GO:0051604;GO:0031400;GO:1901615;GO:0030154;GO:1902991;GO:1902992;GO:1902996;GO:1902997;GO:1904951;GO:0006508;GO:0032502;GO:0014909;GO:0032507;GO:0031333;GO:0060627;GO:0032879;GO:0016482;GO:0051259;GO:0046907;GO:0071702;GO:0030334;GO:0034613;GO:0051174;GO:0051171;GO:0051172;GO:0051649;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:1902582;GO:1902580;GO:0080090;GO:0023014;GO:0010605;GO:0070727;GO:0006469;GO:0010466;GO:0060255;GO:0030162;GO:0030163;GO:0010876;GO:0048870;GO:1903651;GO:0070863;GO:0070861;GO:1901575;GO:0052547;GO:0016043;GO:0098927;GO:0065003;GO:0065007;GO:1903829;GO:0065009;GO:0065008;GO:0036211;GO:0008150;GO:0008152;GO:0043254;GO:0045732;GO:0006869;GO:0016310;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0043086;GO:0043085;GO:0000042;GO:1904684;GO:0061502;GO:0045596;GO:0045595;GO:0071901;GO:0008202;GO:1902988;GO:0051093;GO:0032269;GO:0032268;GO:0043603;GO:0051098;GO:1903337;GO:1903335;GO:0045861;GO:0060628;GO:0014910;GO:0031324;GO:0031323;GO:0072600;GO:0032501;GO:0010941;GO:0071822;GO:0010467;GO:0044085;GO:0032460;GO:0009987;GO:0048193;GO:0007154;GO:1902963;GO:0048699;GO:1902962;GO:0007399;GO:0044087;GO:0015031;GO:1902960;GO:0001933;GO:0001932;GO:1902965;GO:1902966; regulation of intracellular protein transport;regulation of transport;positive regulation of endocytic recycling;small molecule metabolic process;regulation of endocytic recycling;positive regulation of intracellular transport;maintenance of location in cell;cellular response to stimulus;MAPK cascade;regulation of intracellular transport;negative regulation of metallopeptidase activity;regulation of metallopeptidase activity;cell development;regulation of protein kinase activity;regulation of phosphorylation;negative regulation of phosphorylation;protein metabolic process;positive regulation of catabolic process;regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;retrograde transport, vesicle recycling within Golgi;muscle cell migration;positive regulation of protein transport;regulation of protein serine/threonine kinase activity;regulation of biological process;negative regulation of protein binding;ER to Golgi vesicle-mediated transport;negative regulation of hydrolase activity;intracellular protein transport;negative regulation of transferase activity;organic cyclic compound metabolic process;regulation of establishment of protein localization;lipid metabolic process;regulation of cytoplasmic transport;protein targeting to lysosome;protein targeting to vacuole;macromolecule modification;regulation of signal transduction;regulation of protein binding;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;regulation of protein catabolic process;beta-amyloid metabolic process;regulation of neuron death;establishment of localization;regulation of cell development;protein localization to lysosome;response to stimulus;regulation of cellular localization;cell death;multicellular organism development;negative regulation of cell death;protein phosphorylation;protein exit from endoplasmic reticulum;protein complex assembly;positive regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;negative regulation of endopeptidase activity;locomotion;regulation of locomotion;anatomical structure development;alcohol metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;endocytic recycling;phosphorus metabolic process;regulation of protein oligomerization;negative regulation of cellular process;positive regulation of cellular process;protein localization;signal transduction;single-organism metabolic process;inclusion body assembly;organic substance metabolic process;positive regulation of choline O-acetyltransferase activity;regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;positive regulation of molecular function;negative regulation of molecular function;regulation of early endosome to recycling endosome transport;positive regulation of early endosome to recycling endosome transport;macromolecule localization;positive regulation of ER to Golgi vesicle-mediated transport;positive regulation of transport;beta-amyloid formation;secondary alcohol metabolic process;regulation of metalloendopeptidase activity;protein localization to Golgi apparatus;nitrogen compound metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;neuron death;single-organism process;regulation of MAPK cascade;regulation of developmental process;regulation of catalytic activity;regulation of cellular process;regulation of multicellular organismal process;maintenance of location;negative regulation of neuron death;regulation of hydrolase activity;post-Golgi vesicle-mediated transport;intra-Golgi vesicle-mediated transport;endocytosis;receptor-mediated endocytosis;regulation of transferase activity;negative regulation of nervous system development;regulation of nervous system development;regulation of cell motility;peptide metabolic process;negative regulation of phosphorus metabolic process;protein complex biogenesis;establishment of protein localization to vacuole;protein localization to vacuole;negative regulation of MAP kinase activity;regulation of MAP kinase activity;lysosomal transport;negative regulation of MAPK cascade;regulation of protein localization;regulation of neurogenesis;negative regulation of protein metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;negative regulation of neurogenesis;macromolecule catabolic process;regulation of protein modification process;sterol metabolic process;establishment of protein localization to organelle;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;regulation of cellular component movement;vacuolar transport;protein localization to organelle;macromolecular complex subunit organization;intracellular signal transduction;regulation of protein transport;negative regulation of phosphate metabolic process;regulation of endopeptidase activity;positive regulation of transferase activity;neurogenesis;regulation of inclusion body assembly;primary metabolic process;protein localization to endosome;cellular metabolic process;negative regulation of inclusion body assembly;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;cellular component organization or biogenesis;negative regulation of signal transduction;cellular developmental process;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;cholesterol metabolic process;protein targeting;establishment of protein localization;maintenance of protein location;endosomal transport;single organism signaling;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;regulation of tau-protein kinase activity;protein localization to early endosome;negative regulation of tau-protein kinase activity;regulation of beta-amyloid formation;regulation of choline O-acetyltransferase activity;negative regulation of kinase activity;cellular component assembly;negative regulation of binding;movement of cell or subcellular component;localization of cell;amyloid precursor protein catabolic process;macromolecule metabolic process;amyloid precursor protein metabolic process;protein retention in Golgi apparatus;regulation of kinase activity;cell migration;transport;negative regulation of beta-amyloid formation;system development;negative regulation of intracellular signal transduction;regulation of intracellular signal transduction;positive regulation of macromolecule metabolic process;protein maturation;negative regulation of protein modification process;organic hydroxy compound metabolic process;cell differentiation;regulation of amyloid precursor protein catabolic process;negative regulation of amyloid precursor protein catabolic process;regulation of neurofibrillary tangle assembly;negative regulation of neurofibrillary tangle assembly;positive regulation of establishment of protein localization;proteolysis;developmental process;smooth muscle cell migration;maintenance of protein location in cell;negative regulation of protein complex assembly;regulation of vesicle-mediated transport;regulation of localization;cytosolic transport;protein oligomerization;intracellular transport;organic substance transport;regulation of cell migration;cellular protein localization;regulation of phosphorus metabolic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;catabolic process;localization;single-organism localization;cellular localization;single-organism intracellular transport;single-organism cellular localization;regulation of primary metabolic process;signal transduction by protein phosphorylation;negative regulation of macromolecule metabolic process;cellular macromolecule localization;negative regulation of protein kinase activity;negative regulation of peptidase activity;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;lipid localization;cell motility;positive regulation of cytoplasmic transport;positive regulation of protein exit from endoplasmic reticulum;regulation of protein exit from endoplasmic reticulum;organic substance catabolic process;regulation of peptidase activity;cellular component organization;vesicle-mediated transport between endosomal compartments;macromolecular complex assembly;biological regulation;positive regulation of cellular protein localization;regulation of molecular function;regulation of biological quality;protein modification process;biological_process;metabolic process;regulation of protein complex assembly;positive regulation of protein catabolic process;lipid transport;phosphorylation;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;negative regulation of catalytic activity;positive regulation of catalytic activity;protein targeting to Golgi;negative regulation of metalloendopeptidase activity;early endosome to recycling endosome transport;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of protein serine/threonine kinase activity;steroid metabolic process;neurofibrillary tangle assembly;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;regulation of binding;positive regulation of vacuolar transport;regulation of vacuolar transport;negative regulation of proteolysis;regulation of ER to Golgi vesicle-mediated transport;regulation of smooth muscle cell migration;negative regulation of cellular metabolic process;regulation of cellular metabolic process;establishment of protein localization to Golgi;multicellular organismal process;regulation of cell death;protein complex subunit organization;gene expression;cellular component biogenesis;negative regulation of protein oligomerization;cellular process;Golgi vesicle transport;cell communication;negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;generation of neurons;regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;nervous system development;regulation of cellular component biogenesis;protein transport;negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;regulation of protein localization to early endosome;positive regulation of protein localization to early endosome; 6;4;4;4;5;4;4;3;5;5;8;7;4;7;7;7;4;4;4;3;3;8;5;4;8;2;6;7;6;6;6;4;5;4;6;6;5;5;4;5;4;4;5;5;6;5;3;5;8;2;4;4;4;4;7;6;5;4;6;3;4;3;8;2;3;3;5;5;4;6;4;5;3;3;4;4;3;5;3;7;7;4;4;5;6;3;6;3;7;6;8;7;3;5;4;5;2;6;3;4;3;3;3;5;5;7;7;6;7;5;4;5;4;5;5;4;6;7;7;7;7;6;4;6;5;3;5;5;5;5;6;6;5;5;5;4;6;6;4;5;5;6;7;6;6;4;3;8;3;5;6;3;3;3;2;4;4;5;2;2;7;6;4;4;7;3;4;5;3;8;9;9;6;6;7;4;5;4;3;6;4;5;6;6;4;4;6;4;5;5;4;5;6;4;5;6;6;5;6;3;5;2;6;5;5;4;3;6;6;5;5;5;5;5;4;4;4;3;2;3;3;5;4;4;4;4;4;8;7;4;6;5;4;3;5;5;7;4;6;3;6;5;2;3;3;3;5;1;2;4;5;5;6;3;4;2;4;3;4;5;5;5;9;7;4;4;9;5;6;3;5;5;5;4;5;6;6;5;6;4;4;6;2;4;5;5;3;6;2;6;4;7;7;7;5;3;5;7;7;7;6;4; GO:0034358;GO:0044428;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0031226;GO:0031224;GO:0044464;GO:0031970;GO:0071944;GO:0070062;GO:0005615;GO:0005768;GO:0005769;GO:0016021;GO:0016020;GO:0034362;GO:0043230;GO:0043231;GO:0044431;GO:0005641;GO:1990777;GO:0005783;GO:0031974;GO:0031975;GO:0005773;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005635;GO:0005802;GO:0031985;GO:0031984;GO:0031982;GO:0005795;GO:0005794;GO:0031967;GO:0055037;GO:0044459;GO:0005623;GO:0005622;GO:0005887;GO:0005886;GO:1903561;GO:0032994;GO:0032991;GO:0005575;GO:0005576;GO:0098791; plasma lipoprotein particle;nuclear part;intracellular part;membrane part;extracellular region part;organelle part;intrinsic component of plasma membrane;intrinsic component of membrane;cell part;organelle envelope lumen;cell periphery;extracellular exosome;extracellular space;endosome;early endosome;integral component of membrane;membrane;low-density lipoprotein particle;extracellular organelle;intracellular membrane-bounded organelle;Golgi apparatus part;nuclear envelope lumen;lipoprotein particle;endoplasmic reticulum;membrane-enclosed lumen;envelope;vacuole;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nuclear envelope;trans-Golgi network;Golgi cisterna;organelle subcompartment;vesicle;Golgi stack;Golgi apparatus;organelle envelope;recycling endosome;plasma membrane part;cell;intracellular;integral component of plasma membrane;plasma membrane;extracellular vesicle;protein-lipid complex;macromolecular complex;cellular_component;extracellular region;Golgi subcompartment; 3;4;3;2;2;2;4;3;2;3;3;4;3;4;5;4;2;4;3;4;4;4;4;4;2;3;5;3;3;2;3;3;4;4;5;4;5;6;4;4;5;4;4;5;3;2;3;4;3;3;3;2;1;2;5; GO:0005488;GO:0031267;GO:0019899;GO:0099600;GO:0051020;GO:0005515;GO:0044877;GO:0033218;GO:0060089;GO:0003674;GO:0042277;GO:0071813;GO:0071814;GO:0004888;GO:0030169;GO:0030306;GO:0001540;GO:0038023;GO:0004872;GO:0004871; binding;small GTPase binding;enzyme binding;transmembrane receptor activity;GTPase binding;protein binding;macromolecular complex binding;amide binding;molecular transducer activity;molecular_function;peptide binding;lipoprotein particle binding;protein-lipid complex binding;transmembrane signaling receptor activity;low-density lipoprotein particle binding;ADP-ribosylation factor binding;beta-amyloid binding;signaling receptor activity;receptor activity;signal transducer activity; 2;6;4;4;5;3;3;3;2;1;4;5;4;4;6;7;5;3;3;2; IPR006581;IPR013783;IPR023415;IPR031777;IPR031778;IPR003961;IPR015943;IPR011042;IPR000033;IPR002172; VPS10;Immunoglobulin-like fold;Low-density lipoprotein (LDL) receptor class A, conserved site;Sortilin, C-terminal;Sortilin, N-terminal;Fibronectin type III;WD40/YVTN repeat-like-containing domain;Six-bladed beta-propeller, TolB-like;LDLR class B repeat;Low-density lipoprotein (LDL) receptor class A repeat; plasma membrane Hs4507157_2 3052.0 T [T] Signal transduction mechanisms; O75764 Transcription elongation factor A protein 3 OS=Homo sapiens OX=9606 GN=TCEA3 PE=1 SV=2 - [TCEA3_HUMAN] 0.513 1.717 1.149 1.143 0.62 1.394 0.298776937 nan 1.843548387 nan 0.669190448 nan 2.248387097 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0044237;GO:0034645;GO:0043170;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:0032784;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0006357;GO:0065007;GO:1901360;GO:0006366;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0006725;GO:0009987;GO:0009889;GO:0006354;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;regulation of DNA-templated transcription, elongation;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;biological regulation;organic cyclic compound metabolic process;transcription from RNA polymerase II promoter;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;cellular process;regulation of biosynthetic process;DNA-templated transcription, elongation;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;3;5;4;5;2;7;6;7;4;4;6;3;5;7;2;4;7;5;5;4;5;4;2;4;7;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;6;5;6;5; GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 3;5;2;4;2;3;2;3;1;3; GO:0008270;GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:0046914;GO:1901363;GO:0005488; zinc ion binding;cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;transition metal ion binding;heterocyclic compound binding;binding; 7;4;1;5;5;4;3;3;6;3;2; IPR003618;IPR017923;IPR006289;IPR001222;IPR003617;IPR035100; Transcription elongation factor S-II, central domain;Transcription factor IIS, N-terminal;Transcription elongation factor, TFIIS;Zinc finger, TFIIS-type;Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type;Transcription elongation factor, IIS-type; nucleus Hs20473950 716.0 K [K] Transcription; O43795 Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3 - [MYO1B_HUMAN] 0.841 0.96 1.237 1.051 1.135 0.79 0.876041667 nan 0.925991189 nan 1.288541667 nan 0.696035242 nan GO:0071840;GO:0030048;GO:0016192;GO:0022607;GO:0006928;GO:0016043;GO:0006810;GO:0008150;GO:0051234;GO:0006892;GO:0046907;GO:0061572;GO:0044699;GO:0009987;GO:0051017;GO:0043933;GO:0030036;GO:0071822;GO:0044085;GO:0030029;GO:0048193;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0007015;GO:0007010;GO:1902589;GO:1902582; cellular component organization or biogenesis;actin filament-based movement;vesicle-mediated transport;cellular component assembly;movement of cell or subcellular component;cellular component organization;transport;biological_process;establishment of localization;post-Golgi vesicle-mediated transport;intracellular transport;actin filament bundle organization;single-organism process;cellular process;actin filament bundle assembly;macromolecular complex subunit organization;actin cytoskeleton organization;protein complex subunit organization;cellular component biogenesis;actin filament-based process;Golgi vesicle transport;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;actin filament organization;cytoskeleton organization;single-organism organelle organization;single-organism intracellular transport; 2;5;5;4;4;3;4;1;3;7;5;7;2;2;5;4;5;5;3;4;6;4;3;4;2;3;3;4;6;5;4;5; GO:0099512;GO:0099513;GO:0031982;GO:0005773;GO:0016459;GO:0098862;GO:0098588;GO:0042995;GO:0043231;GO:0043234;GO:0043230;GO:0043232;GO:0098858;GO:0044424;GO:0044421;GO:0044422;GO:0030175;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0044437;GO:0048471;GO:0005737;GO:0012505;GO:0044446;GO:0044444;GO:0044440;GO:0016020;GO:0005886;GO:0005903;GO:0010008;GO:0031090;GO:0032991;GO:0005774;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0071944;GO:0070062;GO:0098805;GO:0005884;GO:1903561;GO:0005575;GO:0005576;GO:0005768;GO:0005769; supramolecular fiber;polymeric cytoskeletal fiber;vesicle;vacuole;myosin complex;cluster of actin-based cell projections;bounding membrane of organelle;cell projection;intracellular membrane-bounded organelle;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;actin-based cell projection;intracellular part;extracellular region part;organelle part;filopodium;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;vacuolar part;perinuclear region of cytoplasm;cytoplasm;endomembrane system;intracellular organelle part;cytoplasmic part;endosomal part;membrane;plasma membrane;brush border;endosome membrane;organelle membrane;macromolecular complex;vacuolar membrane;cell part;cell;intracellular;actin cytoskeleton;cell periphery;extracellular exosome;whole membrane;actin filament;extracellular vesicle;cellular_component;extracellular region;endosome;early endosome; 2;3;4;5;4;3;4;3;4;3;3;4;4;3;2;2;5;3;3;3;2;5;4;4;5;4;3;3;4;5;2;3;4;5;3;2;4;2;2;3;6;3;4;3;4;3;1;2;4;5; GO:1901363;GO:1902936;GO:0005543;GO:0005546;GO:0000166;GO:0016818;GO:0097367;GO:0016817;GO:0016787;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0000146;GO:0042623;GO:0003779;GO:0032549;GO:0017076;GO:0003774;GO:0005524;GO:0030898;GO:0003824;GO:1901981;GO:0008092;GO:0035091;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0005547;GO:0043168;GO:0043167;GO:0032403;GO:0008289;GO:0051015;GO:0030554;GO:0005515;GO:0044877;GO:0001883;GO:0001882;GO:0017111;GO:0036094; heterocyclic compound binding;phosphatidylinositol bisphosphate binding;phospholipid binding;phosphatidylinositol-4,5-bisphosphate binding;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;hydrolase activity;molecular_function;binding;ATPase activity;nucleoside phosphate binding;microfilament motor activity;ATPase activity, coupled;actin binding;ribonucleoside binding;purine nucleotide binding;motor activity;ATP binding;actin-dependent ATPase activity;catalytic activity;phosphatidylinositol phosphate binding;cytoskeletal protein binding;phosphatidylinositol binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;phosphatidylinositol-3,4,5-trisphosphate binding;anion binding;ion binding;protein complex binding;lipid binding;actin filament binding;adenyl nucleotide binding;protein binding;macromolecular complex binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding; 3;7;4;8;4;5;3;4;3;1;2;8;4;9;9;5;5;5;8;6;10;2;6;4;5;3;6;6;5;6;4;5;7;4;3;4;3;5;6;3;3;5;4;7;3; K10356 IPR010926;IPR000048;IPR001609;IPR027417; Class I myosin tail homology domain;IQ motif, EF-hand binding site;Myosin head, motor domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs4885503 1209.0 Z [Z] Cytoskeleton; P04114 Apolipoprotein B-100 OS=Homo sapiens OX=9606 GN=APOB PE=1 SV=2 - [APOB_HUMAN] 1.028 1.118 0.903 1.016 1.116 0.843 0.919499106 5.24E-36 0.910394265 2.60E-38 0.807692308 3.22E-23 0.755376344 9.66E-08 GO:0007596;GO:0044281;GO:0044283;GO:0007599;GO:0051716;GO:0000003;GO:0043207;GO:0034694;GO:0016101;GO:0046503;GO:0065005;GO:0007283;GO:0046486;GO:0009607;GO:0009605;GO:0019538;GO:0009566;GO:0010886;GO:0010885;GO:0010884;GO:0010883;GO:0009893;GO:0050789;GO:0097006;GO:1901360;GO:0006629;GO:0071345;GO:0010269;GO:0006695;GO:0006694;GO:0009416;GO:0050878;GO:0030317;GO:0044255;GO:0006898;GO:0042592;GO:0050900;GO:0007275;GO:0007276;GO:0033993;GO:0055092;GO:0019216;GO:0019218;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0048856;GO:0006066;GO:0048522;GO:0008104;GO:0007165;GO:0019915;GO:0044712;GO:0044710;GO:0044711;GO:0033036;GO:0045540;GO:0034367;GO:0034368;GO:0034369;GO:1902653;GO:1902652;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:0044248;GO:0090077;GO:0015918;GO:0015850;GO:0010628;GO:0044260;GO:0001568;GO:0050793;GO:0009889;GO:0050794;GO:0051235;GO:0051234;GO:0006897;GO:0034383;GO:0050896;GO:0034381;GO:0009314;GO:0006639;GO:0006638;GO:0019953;GO:0034374;GO:0070887;GO:0044699;GO:0071379;GO:0051179;GO:0016126;GO:0040011;GO:0071398;GO:0016125;GO:0048609;GO:0071396;GO:0048232;GO:0051674;GO:0002237;GO:0048731;GO:0043933;GO:0046890;GO:0001523;GO:0022414;GO:0042221;GO:0008610;GO:0009628;GO:0009743;GO:0044237;GO:0006775;GO:0019222;GO:0072359;GO:0072358;GO:1901362;GO:0071840;GO:0048869;GO:0048514;GO:0048518;GO:0007603;GO:0007602;GO:0045184;GO:0044700;GO:0044703;GO:0044702;GO:0016192;GO:0044707;GO:0002376;GO:0034377;GO:0022607;GO:0034379;GO:0006928;GO:0044872;GO:0042157;GO:0042158;GO:0042159;GO:0016477;GO:0034097;GO:0006810;GO:0006950;GO:0050817;GO:0050810;GO:0045597;GO:0051606;GO:1901617;GO:1901615;GO:0030154;GO:0009719;GO:0001701;GO:0043009;GO:0071495;GO:0032501;GO:0006642;GO:0032504;GO:0006641;GO:0006721;GO:0006720;GO:0009987;GO:0032870;GO:0032879;GO:0070542;GO:0071229;GO:0071704;GO:0071310;GO:0071702;GO:0034612;GO:0009058;GO:0009059;GO:0009056;GO:0009057;GO:1902578;GO:0048844;GO:0080090;GO:0010604;GO:0009615;GO:0009617;GO:0009611;GO:0006766;GO:0060255;GO:0010878;GO:0030163;GO:0010876;GO:0048870;GO:0048878;GO:0019433;GO:0090181;GO:0032496;GO:1901576;GO:1901575;GO:0071356;GO:0016043;GO:0016042;GO:0065003;GO:0065007;GO:1902930;GO:0065008;GO:0042060;GO:0008150;GO:0008152;GO:0042632;GO:0006869;GO:0030301;GO:0009791;GO:0009790;GO:0009792;GO:0023052;GO:0034645;GO:0044242;GO:0009653;GO:0046464;GO:0046461;GO:0044238;GO:0046165;GO:0055088;GO:0045595;GO:0001101;GO:0008202;GO:0008203;GO:0051094;GO:0009725;GO:0043170;GO:0042953;GO:0032502;GO:0001944;GO:0071825;GO:0071827;GO:0010467;GO:0044085;GO:0010744;GO:0010468;GO:0010742;GO:0010743;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0044249;GO:0007154;GO:0007399;GO:0033344;GO:0015031;GO:0060840; blood coagulation;small molecule metabolic process;small molecule biosynthetic process;hemostasis;cellular response to stimulus;reproduction;response to external biotic stimulus;response to prostaglandin;diterpenoid metabolic process;glycerolipid catabolic process;protein-lipid complex assembly;spermatogenesis;glycerolipid metabolic process;response to biotic stimulus;response to external stimulus;protein metabolic process;fertilization;positive regulation of cholesterol storage;regulation of cholesterol storage;positive regulation of lipid storage;regulation of lipid storage;positive regulation of metabolic process;regulation of biological process;regulation of plasma lipoprotein particle levels;organic cyclic compound metabolic process;lipid metabolic process;cellular response to cytokine stimulus;response to selenium ion;cholesterol biosynthetic process;steroid biosynthetic process;response to light stimulus;regulation of body fluid levels;sperm motility;cellular lipid metabolic process;receptor-mediated endocytosis;homeostatic process;leukocyte migration;multicellular organism development;gamete generation;response to lipid;sterol homeostasis;regulation of lipid metabolic process;regulation of steroid metabolic process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;anatomical structure development;alcohol metabolic process;positive regulation of cellular process;protein localization;signal transduction;lipid storage;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;macromolecule localization;regulation of cholesterol biosynthetic process;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;secondary alcohol biosynthetic process;secondary alcohol metabolic process;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;cellular catabolic process;foam cell differentiation;sterol transport;organic hydroxy compound transport;positive regulation of gene expression;cellular macromolecule metabolic process;blood vessel development;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;maintenance of location;establishment of localization;endocytosis;low-density lipoprotein particle clearance;response to stimulus;plasma lipoprotein particle clearance;response to radiation;acylglycerol metabolic process;neutral lipid metabolic process;sexual reproduction;low-density lipoprotein particle remodeling;cellular response to chemical stimulus;single-organism process;cellular response to prostaglandin stimulus;localization;sterol biosynthetic process;locomotion;cellular response to fatty acid;sterol metabolic process;multicellular organismal reproductive process;cellular response to lipid;male gamete generation;localization of cell;response to molecule of bacterial origin;system development;macromolecular complex subunit organization;regulation of lipid biosynthetic process;retinoid metabolic process;reproductive process;response to chemical;lipid biosynthetic process;response to abiotic stimulus;response to carbohydrate;cellular metabolic process;fat-soluble vitamin metabolic process;regulation of metabolic process;circulatory system development;cardiovascular system development;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular developmental process;blood vessel morphogenesis;positive regulation of biological process;phototransduction, visible light;phototransduction;establishment of protein localization;single organism signaling;multi-organism reproductive process;single organism reproductive process;vesicle-mediated transport;single-multicellular organism process;immune system process;plasma lipoprotein particle assembly;cellular component assembly;very-low-density lipoprotein particle assembly;movement of cell or subcellular component;lipoprotein localization;lipoprotein metabolic process;lipoprotein biosynthetic process;lipoprotein catabolic process;cell migration;response to cytokine;transport;response to stress;coagulation;regulation of steroid biosynthetic process;positive regulation of cell differentiation;detection of stimulus;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;cell differentiation;response to endogenous stimulus;in utero embryonic development;chordate embryonic development;cellular response to endogenous stimulus;multicellular organismal process;triglyceride mobilization;multicellular organism reproduction;triglyceride metabolic process;terpenoid metabolic process;isoprenoid metabolic process;cellular process;cellular response to hormone stimulus;regulation of localization;response to fatty acid;cellular response to acid chemical;organic substance metabolic process;cellular response to organic substance;organic substance transport;response to tumor necrosis factor;biosynthetic process;macromolecule biosynthetic process;catabolic process;macromolecule catabolic process;single-organism localization;artery morphogenesis;regulation of primary metabolic process;positive regulation of macromolecule metabolic process;response to virus;response to bacterium;response to wounding;vitamin metabolic process;regulation of macromolecule metabolic process;cholesterol storage;protein catabolic process;lipid localization;cell motility;chemical homeostasis;triglyceride catabolic process;regulation of cholesterol metabolic process;response to lipopolysaccharide;organic substance biosynthetic process;organic substance catabolic process;cellular response to tumor necrosis factor;cellular component organization;lipid catabolic process;macromolecular complex assembly;biological regulation;regulation of alcohol biosynthetic process;regulation of biological quality;wound healing;biological_process;metabolic process;cholesterol homeostasis;lipid transport;cholesterol transport;post-embryonic development;embryo development;embryo development ending in birth or egg hatching;signaling;cellular macromolecule biosynthetic process;cellular lipid catabolic process;anatomical structure morphogenesis;acylglycerol catabolic process;neutral lipid catabolic process;primary metabolic process;alcohol biosynthetic process;lipid homeostasis;regulation of cell differentiation;response to acid chemical;steroid metabolic process;cholesterol metabolic process;positive regulation of developmental process;response to hormone;macromolecule metabolic process;lipoprotein transport;developmental process;vasculature development;protein-lipid complex subunit organization;plasma lipoprotein particle organization;gene expression;cellular component biogenesis;positive regulation of macrophage derived foam cell differentiation;regulation of gene expression;macrophage derived foam cell differentiation;regulation of macrophage derived foam cell differentiation;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;cellular biosynthetic process;cell communication;nervous system development;cholesterol efflux;protein transport;artery development; 5;4;5;5;3;2;4;5;7;6;6;6;5;3;3;4;4;4;5;3;4;3;2;3;4;4;6;5;8;6;5;4;4;4;7;4;3;4;4;5;7;5;6;3;4;3;4;5;3;5;3;4;4;4;4;3;4;3;6;5;6;4;7;6;4;3;4;2;4;6;6;5;5;4;4;3;4;3;3;3;6;5;2;4;4;6;5;3;5;4;2;6;2;7;2;6;6;3;6;5;3;5;4;4;5;8;2;3;5;3;5;3;6;3;5;5;5;2;4;4;2;6;5;4;3;3;3;5;3;2;4;4;5;4;5;5;6;6;4;5;4;3;4;6;4;3;5;4;5;3;8;7;4;2;8;3;7;6;5;2;5;3;5;5;3;5;5;6;3;5;3;5;3;5;4;4;4;4;4;5;4;5;5;4;3;5;8;7;5;4;4;7;3;5;5;2;5;3;5;1;2;8;5;7;4;5;6;2;5;5;3;7;6;3;6;6;4;4;5;7;3;4;4;5;2;5;5;4;5;3;5;5;7;5;4;4;5;6;4;4;5;8;5;5; GO:0034359;GO:0034358;GO:0031974;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043025;GO:0042175;GO:0010008;GO:0044464;GO:0071944;GO:0005615;GO:0005622;GO:0070062;GO:0070013;GO:0005768;GO:0005769;GO:0071682;GO:0016023;GO:0016020;GO:0034360;GO:0034361;GO:0034362;GO:0034363;GO:0098588;GO:0044297;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044433;GO:0044432;GO:0044437;GO:0034385;GO:1990777;GO:0060205;GO:0030665;GO:0030666;GO:0031090;GO:0030662;GO:0030669;GO:0005783;GO:0005788;GO:0005789;GO:0005773;GO:0005775;GO:0005774;GO:0031904;GO:0036477;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0042627;GO:0012505;GO:0012506;GO:0031982;GO:0044446;GO:0044444;GO:0045334;GO:0044440;GO:0030659;GO:0015629;GO:0031983;GO:0031988;GO:0005576;GO:0005794;GO:0005737;GO:0097708;GO:0031410;GO:0005623;GO:0030139;GO:0030135;GO:0030136;GO:0098805;GO:0097458;GO:0005886;GO:1903561;GO:0032994;GO:0032991;GO:0005575; mature chylomicron;plasma lipoprotein particle;membrane-enclosed lumen;intracellular part;membrane part;extracellular region part;organelle part;neuronal cell body;nuclear outer membrane-endoplasmic reticulum membrane network;endosome membrane;cell part;cell periphery;extracellular space;intracellular;extracellular exosome;intracellular organelle lumen;endosome;early endosome;endocytic vesicle lumen;cytoplasmic, membrane-bounded vesicle;membrane;chylomicron remnant;very-low-density lipoprotein particle;low-density lipoprotein particle;intermediate-density lipoprotein particle;bounding membrane of organelle;cell body;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;cytoplasmic vesicle part;endoplasmic reticulum part;vacuolar part;triglyceride-rich lipoprotein particle;lipoprotein particle;cytoplasmic membrane-bounded vesicle lumen;clathrin-coated vesicle membrane;endocytic vesicle membrane;organelle membrane;coated vesicle membrane;clathrin-coated endocytic vesicle membrane;endoplasmic reticulum;endoplasmic reticulum lumen;endoplasmic reticulum membrane;vacuole;vacuolar lumen;vacuolar membrane;endosome lumen;somatodendritic compartment;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;chylomicron;endomembrane system;vesicle membrane;vesicle;intracellular organelle part;cytoplasmic part;clathrin-coated endocytic vesicle;endosomal part;cytoplasmic vesicle membrane;actin cytoskeleton;vesicle lumen;membrane-bounded vesicle;extracellular region;Golgi apparatus;cytoplasm;intracellular vesicle;cytoplasmic vesicle;cell;endocytic vesicle;coated vesicle;clathrin-coated vesicle;whole membrane;neuron part;plasma membrane;extracellular vesicle;protein-lipid complex;macromolecular complex;cellular_component; 5;3;2;3;2;2;2;4;3;5;2;3;3;3;4;4;4;5;6;5;2;5;5;4;5;4;3;3;4;4;3;5;4;4;4;4;4;5;5;4;3;4;5;4;5;3;5;5;4;6;4;3;3;3;2;5;4;3;4;4;3;4;7;5;5;6;4;5;2;4;4;4;5;2;6;6;7;3;3;3;3;3;2;1; GO:0005488;GO:1901681;GO:0008289;GO:0017127;GO:0022892;GO:0019899;GO:0050750;GO:0005215;GO:0005515;GO:0005102;GO:0035473;GO:0003674;GO:0005543;GO:0043167;GO:0005319;GO:0097367;GO:0015248;GO:0005539;GO:0008201;GO:0070325;GO:0043168; binding;sulfur compound binding;lipid binding;cholesterol transporter activity;substrate-specific transporter activity;enzyme binding;low-density lipoprotein particle receptor binding;transporter activity;protein binding;receptor binding;lipase binding;molecular_function;phospholipid binding;ion binding;lipid transporter activity;carbohydrate derivative binding;sterol transporter activity;glycosaminoglycan binding;heparin binding;lipoprotein particle receptor binding;anion binding; 2;3;3;6;3;4;6;2;3;4;5;1;4;3;4;3;5;4;4;5;4; K14462 map04975;map04977; Fat digestion and absorption;Vitamin digestion and absorption; IPR016024;IPR022176;IPR009454;IPR015817;IPR015816;IPR011030;IPR015255;IPR001747;IPR015819; Armadillo-type fold;Apolipoprotein B100 C-terminal;Lipid transport, open beta-sheet;Vitellinogen, open beta-sheet, subdomain 1;Vitellinogen, beta-sheet N-terminal;Vitellinogen, superhelical;Vitellinogen, open beta-sheet;Lipid transport protein, N-terminal;Lipid transport protein, beta-sheet shell; endoplasmic reticulum Hs4502153 9381.0 I [I] Lipid transport and metabolism; Q15545 Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1 - [TAF7_HUMAN] 0.904 1.232 0.606 1.443 1.17 1.134 0.733766234 0.004832561 1.233333333 0.05906267 0.491883117 0.00043404 0.969230769 0.89812609 GO:0051348;GO:0019220;GO:0080090;GO:0019222;GO:0035067;GO:0043543;GO:0006473;GO:0030518;GO:0006475;GO:0043401;GO:0007165;GO:0031057;GO:0031056;GO:1901362;GO:1901360;GO:0035065;GO:0009755;GO:0051716;GO:0010605;GO:0010604;GO:0071840;GO:0071310;GO:0018193;GO:0044092;GO:0048518;GO:0048519;GO:0016570;GO:0060255;GO:0045859;GO:0042221;GO:2001141;GO:0010033;GO:0046483;GO:0042325;GO:0044700;GO:0042326;GO:0019538;GO:0010639;GO:2001251;GO:0018205;GO:0051254;GO:0071407;GO:0019438;GO:0033673;GO:0009892;GO:0070887;GO:0009890;GO:0009891;GO:1902589;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0043549;GO:0016043;GO:0065007;GO:0014070;GO:1903308;GO:0006366;GO:0065009;GO:0018130;GO:0018393;GO:0009719;GO:0018394;GO:0050790;GO:0009889;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016573;GO:1903309;GO:0016070;GO:0051174;GO:0044271;GO:0031400;GO:1901984;GO:0051338;GO:0006355;GO:0010556;GO:0006351;GO:0006352;GO:0016569;GO:0010558;GO:1901983;GO:0033044;GO:0032774;GO:0033043;GO:0016310;GO:0051129;GO:0051128;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007154;GO:0043086;GO:0044699;GO:0009893;GO:0006139;GO:0051248;GO:0000122;GO:0010563;GO:0051246;GO:0043933;GO:0031399;GO:0031325;GO:0006367;GO:0071495;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0032870;GO:0045892;GO:0045893;GO:0032269;GO:0032268;GO:0009725;GO:0051253;GO:0051252;GO:0010629;GO:0043170;GO:1902680;GO:0010628;GO:0045944;GO:0050896;GO:0048545;GO:1902275;GO:1903508;GO:0010557;GO:0031328;GO:0031327;GO:0031326;GO:0071383;GO:0031324;GO:0031323;GO:0090304;GO:0030522;GO:0030520;GO:0006325;GO:0033993;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0045936;GO:0010468;GO:0006468;GO:0006469;GO:0045935;GO:0045934;GO:0044267;GO:0019219;GO:0071396;GO:2000757;GO:0006464;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0016568;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0006796;GO:2000756;GO:0006793;GO:0001933;GO:0001932;GO:0048523;GO:0048522; negative regulation of transferase activity;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of histone acetylation;protein acylation;protein acetylation;intracellular steroid hormone receptor signaling pathway;internal protein amino acid acetylation;steroid hormone mediated signaling pathway;signal transduction;negative regulation of histone modification;regulation of histone modification;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of histone acetylation;hormone-mediated signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular component organization or biogenesis;cellular response to organic substance;peptidyl-amino acid modification;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;histone modification;regulation of macromolecule metabolic process;regulation of protein kinase activity;response to chemical;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;protein metabolic process;negative regulation of organelle organization;negative regulation of chromosome organization;peptidyl-lysine modification;positive regulation of RNA metabolic process;cellular response to organic cyclic compound;aromatic compound biosynthetic process;negative regulation of kinase activity;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of biosynthetic process;positive regulation of biosynthetic process;single-organism organelle organization;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of kinase activity;cellular component organization;biological regulation;response to organic cyclic compound;regulation of chromatin modification;transcription from RNA polymerase II promoter;regulation of molecular function;heterocycle biosynthetic process;internal peptidyl-lysine acetylation;response to endogenous stimulus;peptidyl-lysine acetylation;regulation of catalytic activity;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;histone acetylation;negative regulation of chromatin modification;RNA metabolic process;regulation of phosphorus metabolic process;cellular nitrogen compound biosynthetic process;negative regulation of protein modification process;negative regulation of protein acetylation;regulation of transferase activity;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;covalent chromatin modification;negative regulation of macromolecule biosynthetic process;regulation of protein acetylation;regulation of chromosome organization;RNA biosynthetic process;regulation of organelle organization;phosphorylation;negative regulation of cellular component organization;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;negative regulation of catalytic activity;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;macromolecular complex subunit organization;regulation of protein modification process;positive regulation of cellular metabolic process;transcription initiation from RNA polymerase II promoter;cellular response to endogenous stimulus;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to hormone stimulus;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;response to hormone;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;response to stimulus;response to steroid hormone;regulation of chromatin organization;positive regulation of nucleic acid-templated transcription;positive regulation of macromolecule biosynthetic process;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;cellular response to steroid hormone stimulus;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;intracellular receptor signaling pathway;intracellular estrogen receptor signaling pathway;chromatin organization;response to lipid;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;negative regulation of phosphate metabolic process;regulation of gene expression;protein phosphorylation;negative regulation of protein kinase activity;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular response to lipid;negative regulation of peptidyl-lysine acetylation;cellular protein modification process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;chromatin modification;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;phosphate-containing compound metabolic process;regulation of peptidyl-lysine acetylation;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;6;4;3;6;7;8;6;9;6;4;5;5;5;4;6;5;3;4;4;2;5;7;4;2;2;4;4;7;3;6;4;4;7;3;7;4;5;6;8;5;6;5;7;3;4;4;4;4;3;7;4;4;6;3;2;5;7;7;3;5;10;3;9;4;4;3;3;5;5;1;2;5;5;7;5;5;5;6;7;5;6;5;6;7;7;5;7;6;6;5;6;4;4;4;4;2;5;4;5;2;3;4;5;7;5;5;4;6;4;8;4;2;4;7;7;5;6;6;5;5;4;5;5;5;4;6;5;7;2;5;6;7;5;5;5;5;6;4;4;5;5;7;5;5;6;6;2;3;5;7;6;5;7;8;5;5;5;5;6;8;6;6;3;5;3;4;4;4;6;4;3;5;3;5;8;4;7;7;3;3; GO:0031974;GO:0016591;GO:0031981;GO:0044798;GO:0005794;GO:1902493;GO:1902494;GO:1902554;GO:0033276;GO:1990234;GO:0019908;GO:0030880;GO:0043231;GO:0043233;GO:0044428;GO:0005667;GO:0044424;GO:0044422;GO:0000428;GO:0000307;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0071339;GO:0005669;GO:0012505;GO:0044446;GO:0044444;GO:0032806;GO:0090575;GO:0008023;GO:0008024;GO:0005737;GO:0000123;GO:1902911;GO:0005634;GO:0044451;GO:0055029;GO:0061695;GO:0031248;GO:0044464;GO:0005623;GO:0070461;GO:0044665;GO:0035097;GO:0034708;GO:0043234;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;DNA-directed RNA polymerase II, holoenzyme;nuclear lumen;nuclear transcription factor complex;Golgi apparatus;acetyltransferase complex;catalytic complex;serine/threonine protein kinase complex;transcription factor TFTC complex;transferase complex;nuclear cyclin-dependent protein kinase holoenzyme complex;RNA polymerase complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;transcription factor complex;intracellular part;organelle part;DNA-directed RNA polymerase complex;cyclin-dependent protein kinase holoenzyme complex;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;MLL1 complex;transcription factor TFIID complex;endomembrane system;intracellular organelle part;cytoplasmic part;carboxy-terminal domain protein kinase complex;RNA polymerase II transcription factor complex;transcription elongation factor complex;cyclin/CDK positive transcription elongation factor complex;cytoplasm;histone acetyltransferase complex;protein kinase complex;nucleus;nucleoplasm part;nuclear DNA-directed RNA polymerase complex;transferase complex, transferring phosphorus-containing groups;protein acetyltransferase complex;cell part;cell;SAGA-type complex;MLL1/2 complex;histone methyltransferase complex;methyltransferase complex;protein complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;6;5;5;4;6;4;8;7;5;5;4;4;3;4;4;3;2;5;4;3;3;3;2;5;7;6;3;3;4;5;6;4;5;4;5;7;5;5;5;6;4;2;2;6;6;5;4;3;2;1;4; GO:1901363;GO:0003713;GO:0003712;GO:0044212;GO:0001071;GO:0000989;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000988;GO:0097159;GO:0000975;GO:0001067;GO:0003700; heterocyclic compound binding;transcription coactivator activity;transcription cofactor activity;transcription regulatory region DNA binding;nucleic acid binding transcription factor activity;transcription factor activity, transcription factor binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, protein binding;organic cyclic compound binding;regulatory region DNA binding;regulatory region nucleic acid binding;transcription factor activity, sequence-specific DNA binding; 3;5;4;7;2;3;1;2;4;5;2;3;6;5;3; K03132 map03022; Basal transcription factors; IPR006751; TAFII55 protein, conserved region; nucleus Hs14717407 707.0 K [K] Transcription; Q8IVL0 Neuron navigator 3 OS=Homo sapiens OX=9606 GN=NAV3 PE=1 SV=3 - [NAV3_HUMAN] 1.066 1.104 1.026 1.166 0.807 1.168 0.96557971 nan 1.444857497 nan 0.929347826 nan 1.447335812 nan GO:0005635;GO:0031975;GO:0042175;GO:0043229;GO:0043227;GO:0043226;GO:0005575;GO:0031090;GO:0005634;GO:0016020;GO:0031968;GO:0098588;GO:0031965;GO:0031967;GO:0012505;GO:0043231;GO:0005640;GO:0044464;GO:0019867;GO:0005623;GO:0005622;GO:0044446;GO:0044428;GO:0044424;GO:0044425;GO:0098805;GO:0044422; nuclear envelope;envelope;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;membrane-bounded organelle;organelle;cellular_component;organelle membrane;nucleus;membrane;organelle outer membrane;bounding membrane of organelle;nuclear membrane;organelle envelope;endomembrane system;intracellular membrane-bounded organelle;nuclear outer membrane;cell part;outer membrane;cell;intracellular;intracellular organelle part;nuclear part;intracellular part;membrane part;whole membrane;organelle part; 4;3;3;3;3;2;1;3;5;2;4;4;4;4;3;4;3;2;3;2;3;3;4;3;2;3;2; GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0000166;GO:1901265;GO:0001882;GO:0043168;GO:0043167;GO:0001883;GO:0032549;GO:0032559;GO:0005524;GO:0036094;GO:0032555;GO:0017076;GO:0030554;GO:0097367;GO:0097159;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;nucleotide binding;nucleoside phosphate binding;nucleoside binding;anion binding;ion binding;purine nucleoside binding;ribonucleoside binding;adenyl ribonucleotide binding;ATP binding;small molecule binding;purine ribonucleotide binding;purine nucleotide binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;purine ribonucleoside binding;ribonucleotide binding; 5;3;1;2;4;4;4;4;3;5;5;6;6;3;5;5;6;3;3;6;4; IPR001715;IPR003959;IPR003593;IPR027417; Calponin homology domain;ATPase, AAA-type, core;AAA+ ATPase domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs19923814 2248.0 Y [Y] Nuclear structure; Q8IVL1 Neuron navigator 2 OS=Homo sapiens OX=9606 GN=NAV2 PE=1 SV=3 - [NAV2_HUMAN] 0.675 0.76 1.707 0.699 1.301 0.52 0.888157895 nan 0.537279016 nan 2.246052632 nan 0.399692544 nan GO:0007610;GO:0003013;GO:0007608;GO:0007605;GO:0007606;GO:0007600;GO:0003008;GO:0044707;GO:0021783;GO:0048486;GO:0003073;GO:0007626;GO:0065007;GO:0065008;GO:0008015;GO:0050954;GO:0008150;GO:0021545;GO:0044767;GO:0001976;GO:0021554;GO:0044699;GO:0007417;GO:0032502;GO:0032501;GO:0050877;GO:0021564;GO:0021563;GO:0021675;GO:0048731;GO:0048483;GO:0008217;GO:0007275;GO:0003025;GO:0007399;GO:0048856; behavior;circulatory system process;sensory perception of smell;sensory perception of sound;sensory perception of chemical stimulus;sensory perception;system process;single-multicellular organism process;preganglionic parasympathetic fiber development;parasympathetic nervous system development;regulation of systemic arterial blood pressure;locomotory behavior;biological regulation;regulation of biological quality;blood circulation;sensory perception of mechanical stimulus;biological_process;cranial nerve development;single-organism developmental process;neurological system process involved in regulation of systemic arterial blood pressure;optic nerve development;single-organism process;central nervous system development;developmental process;multicellular organismal process;neurological system process;vagus nerve development;glossopharyngeal nerve development;nerve development;system development;autonomic nervous system development;regulation of blood pressure;multicellular organism development;regulation of systemic arterial blood pressure by baroreceptor feedback;nervous system development;anatomical structure development; 2;4;7;7;6;5;3;3;5;5;5;3;2;3;5;6;1;5;3;5;6;2;5;2;2;4;6;6;4;4;5;4;4;6;5;3; GO:0031981;GO:0031974;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0031012;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0005614;GO:0005575;GO:0070013;GO:0005576;GO:0005578; nuclear lumen;membrane-enclosed lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;extracellular matrix;nucleus;cell part;cell;intracellular;intracellular organelle part;interstitial matrix;cellular_component;intracellular organelle lumen;extracellular region;proteinaceous extracellular matrix; 5;2;4;3;4;3;2;2;3;3;2;5;2;5;2;2;3;3;4;1;4;2;3; GO:1901363;GO:0000166;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0097159;GO:0005539;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0043167;GO:0008201;GO:0030554;GO:1901681;GO:0001883;GO:0001882;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;organic cyclic compound binding;glycosaminoglycan binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;ion binding;heparin binding;adenyl nucleotide binding;sulfur compound binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding; 3;4;8;5;3;4;1;2;4;5;5;6;3;2;3;4;6;6;5;6;4;5;4;3;4;6;3;5;4;7;3; K19483 IPR001715;IPR003593;IPR027417; Calponin homology domain;AAA+ ATPase domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs19923814 4936.0 Y [Y] Nuclear structure; P30291 Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2 - [WEE1_HUMAN] 1.377 0.97 0.786 0.885 1.123 1.148 1.419587629 nan 0.788067676 nan 0.810309278 nan 1.022261799 nan GO:0007599;GO:0000086;GO:0007596;GO:0000082;GO:0007163;GO:0044707;GO:0071840;GO:0048869;GO:0009611;GO:0048468;GO:0050789;GO:0031175;GO:0007067;GO:0000902;GO:0016043;GO:0065007;GO:0007049;GO:0065008;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0050896;GO:0048812;GO:0030154;GO:0030010;GO:0009653;GO:0044699;GO:0000280;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0032990;GO:0048731;GO:0044839;GO:0030030;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0007275;GO:0051301;GO:0032989;GO:0048666;GO:0000278;GO:0030182;GO:0044767;GO:0000226;GO:0044763;GO:0044843;GO:0022008;GO:0006996;GO:0048699;GO:0007017;GO:0007010;GO:0048858;GO:0007399;GO:0051726;GO:0048856;GO:1902589;GO:0048285; hemostasis;G2/M transition of mitotic cell cycle;blood coagulation;G1/S transition of mitotic cell cycle;establishment or maintenance of cell polarity;single-multicellular organism process;cellular component organization or biogenesis;cellular developmental process;response to wounding;cell development;regulation of biological process;neuron projection development;mitotic nuclear division;cell morphogenesis;cellular component organization;biological regulation;cell cycle;regulation of biological quality;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;response to stimulus;neuron projection morphogenesis;cell differentiation;establishment of cell polarity;anatomical structure morphogenesis;single-organism process;nuclear division;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;cell part morphogenesis;system development;cell cycle G2/M phase transition;cell projection organization;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;multicellular organism development;cell division;cellular component morphogenesis;neuron development;mitotic cell cycle;neuron differentiation;single-organism developmental process;microtubule cytoskeleton organization;single-organism cellular process;cell cycle G1/S phase transition;neurogenesis;organelle organization;generation of neurons;microtubule-based process;cytoskeleton organization;cell projection morphogenesis;nervous system development;regulation of cell cycle;anatomical structure development;single-organism organelle organization;organelle fission; 5;6;5;7;4;3;2;4;4;4;2;5;5;5;3;2;4;3;5;3;3;4;1;2;6;5;5;3;2;6;2;2;4;2;5;4;6;4;5;5;6;4;4;4;4;5;5;6;3;5;3;6;6;4;7;4;5;5;5;4;3;4;5; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleolus;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;2;3;3;3;2;5;3;4;5;5;2;2;3;1;4; GO:0000166;GO:0016740;GO:0004715;GO:0004713;GO:0046872;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0036094;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043169;GO:0000287;GO:0043167;GO:0030554;GO:0097159;GO:0001882;GO:0001883;GO:0004672; nucleotide binding;transferase activity;non-membrane spanning protein tyrosine kinase activity;protein tyrosine kinase activity;metal ion binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;kinase activity;catalytic activity;small molecule binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;cation binding;magnesium ion binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;nucleoside binding;purine nucleoside binding;protein kinase activity; 4;3;8;7;5;3;1;2;4;3;5;5;6;4;5;2;3;5;4;6;5;6;4;5;4;6;3;6;3;4;5;6; K06632 map04110; Cell cycle; IPR017441;IPR008271;IPR017164;IPR011009;IPR000719; Protein kinase, ATP binding site;Serine/threonine-protein kinase, active site;Wee1-like protein kinase;Protein kinase-like domain;Protein kinase domain; nucleus Hs4507917 1332.0 D [D] Cell cycle control, cell division, chromosome partitioning; Q14896 Myosin-binding protein C, cardiac-type OS=Homo sapiens OX=9606 GN=MYBPC3 PE=1 SV=4 - [MYPC3_HUMAN] 0.835 1.249 1.184 0.806 1.195 0.545 0.668534828 nan 0.674476987 nan 0.947958367 nan 0.456066946 nan GO:0051049;GO:0032386;GO:0072359;GO:0072358;GO:0003015;GO:0007517;GO:0048513;GO:0044093;GO:0006936;GO:0006937;GO:0032781;GO:0003007;GO:0030048;GO:0030049;GO:0003008;GO:0006941;GO:0044707;GO:0003012;GO:0060047;GO:0003013;GO:0060415;GO:0006928;GO:0050789;GO:0003205;GO:0003206;GO:0051345;GO:0003208;GO:0065007;GO:0043085;GO:0065009;GO:0048644;GO:0009887;GO:0006810;GO:0008015;GO:0050790;GO:0009888;GO:0050794;GO:0008150;GO:0051239;GO:0003231;GO:0051234;GO:0051336;GO:0046907;GO:0006942;GO:0003229;GO:0061061;GO:0009653;GO:0060048;GO:0044699;GO:0044057;GO:0033275;GO:0022610;GO:0032502;GO:0032501;GO:1903115;GO:0055008;GO:0032971;GO:0009987;GO:0032879;GO:0048738;GO:0048731;GO:0060341;GO:0055010;GO:0014706;GO:0007275;GO:0043462;GO:0048729;GO:0032970;GO:0030029;GO:0044767;GO:0044763;GO:0090257;GO:0051649;GO:0007155;GO:0051179;GO:0051641;GO:0007507;GO:0051270;GO:0048856;GO:0060537;GO:0070252; regulation of transport;regulation of intracellular transport;circulatory system development;cardiovascular system development;heart process;muscle organ development;animal organ development;positive regulation of molecular function;muscle contraction;regulation of muscle contraction;positive regulation of ATPase activity;heart morphogenesis;actin filament-based movement;muscle filament sliding;system process;striated muscle contraction;single-multicellular organism process;muscle system process;heart contraction;circulatory system process;muscle tissue morphogenesis;movement of cell or subcellular component;regulation of biological process;cardiac chamber development;cardiac chamber morphogenesis;positive regulation of hydrolase activity;cardiac ventricle morphogenesis;biological regulation;positive regulation of catalytic activity;regulation of molecular function;muscle organ morphogenesis;organ morphogenesis;transport;blood circulation;regulation of catalytic activity;tissue development;regulation of cellular process;biological_process;regulation of multicellular organismal process;cardiac ventricle development;establishment of localization;regulation of hydrolase activity;intracellular transport;regulation of striated muscle contraction;ventricular cardiac muscle tissue development;muscle structure development;anatomical structure morphogenesis;cardiac muscle contraction;single-organism process;regulation of system process;actin-myosin filament sliding;biological adhesion;developmental process;multicellular organismal process;regulation of actin filament-based movement;cardiac muscle tissue morphogenesis;regulation of muscle filament sliding;cellular process;regulation of localization;cardiac muscle tissue development;system development;regulation of cellular localization;ventricular cardiac muscle tissue morphogenesis;striated muscle tissue development;multicellular organism development;regulation of ATPase activity;tissue morphogenesis;regulation of actin filament-based process;actin filament-based process;single-organism developmental process;single-organism cellular process;regulation of muscle system process;establishment of localization in cell;cell adhesion;localization;cellular localization;heart development;regulation of cellular component movement;anatomical structure development;muscle tissue development;actin-mediated cell contraction; 4;5;5;5;5;5;4;4;5;6;7;5;5;6;3;6;3;4;6;4;5;4;2;4;4;6;5;2;5;3;5;4;4;5;4;4;3;1;3;5;3;5;5;7;6;4;3;7;2;4;7;2;2;2;5;6;6;2;3;5;4;4;6;6;4;6;4;4;4;3;3;5;4;3;2;3;4;4;3;5;6; GO:0043234;GO:0036379;GO:0043232;GO:0005829;GO:0044424;GO:0043229;GO:0043228;GO:0031672;GO:0005859;GO:0044430;GO:0044446;GO:0044444;GO:0016460;GO:0044422;GO:0044449;GO:0030016;GO:0030017;GO:0005737;GO:0016459;GO:0005863;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0014705;GO:0032982;GO:0043226;GO:0005856;GO:0032991;GO:0005575;GO:0043292; protein complex;myofilament;intracellular non-membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;non-membrane-bounded organelle;A band;muscle myosin complex;cytoskeletal part;intracellular organelle part;cytoplasmic part;myosin II complex;organelle part;contractile fiber part;myofibril;sarcomere;cytoplasm;myosin complex;striated muscle myosin thick filament;cell part;cell;intracellular;actin cytoskeleton;C zone;myosin filament;organelle;cytoskeleton;macromolecular complex;cellular_component;contractile fiber; 3;4;4;5;3;3;3;4;4;4;3;4;5;2;3;6;4;4;4;5;2;2;3;6;4;5;2;5;2;1;5; GO:0005198;GO:0060589;GO:0046872;GO:0060590;GO:0003674;GO:0005488;GO:0008307;GO:0001671;GO:0008092;GO:0017022;GO:0043169;GO:0043167;GO:0042802;GO:0005515;GO:0008047;GO:0031432;GO:0032036;GO:0030234;GO:0098772; structural molecule activity;nucleoside-triphosphatase regulator activity;metal ion binding;ATPase regulator activity;molecular_function;binding;structural constituent of muscle;ATPase activator activity;cytoskeletal protein binding;myosin binding;cation binding;ion binding;identical protein binding;protein binding;enzyme activator activity;titin binding;myosin heavy chain binding;enzyme regulator activity;molecular function regulator; 2;4;5;5;1;2;3;5;4;5;4;3;4;3;4;5;6;3;2; K12568 map05410;map05414; Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy; IPR003599;IPR003598;IPR013783;IPR013098;IPR007110;IPR003961; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;Immunoglobulin I-set;Immunoglobulin-like domain;Fibronectin type III; cytosol 556567923 81.6 X [X] Mobilome: prophages, transposons; COG4733 Phage-related protein, tail component P05543 Thyroxine-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA7 PE=1 SV=2 - [THBG_HUMAN] 0.981 1.046 0.96 0.986 1.073 0.929 0.937858509 0.043482657 0.918918919 0.075310645 0.917782027 0.190413832 0.865796831 0.326731697 GO:0009892;GO:0019222;GO:0050794;GO:0044092;GO:0031324;GO:0031323;GO:0045861;GO:0008152;GO:0050789;GO:0072337;GO:0044699;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0006508;GO:0051246;GO:0043086;GO:0071705;GO:0071704;GO:0043170;GO:0010466;GO:0065007;GO:0071702;GO:0048519;GO:0065009;GO:0065008;GO:0006810;GO:0052547;GO:0052548;GO:0070327;GO:0010817;GO:0044765;GO:0008150;GO:0010951;GO:0051234;GO:0051346;GO:0051179;GO:1902578;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0050790;GO:0060255;GO:0044237;GO:0009914;GO:0019538;GO:0030162;GO:0009987;GO:0048523; negative regulation of metabolic process;regulation of metabolic process;regulation of cellular process;negative regulation of molecular function;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of proteolysis;metabolic process;regulation of biological process;modified amino acid transport;single-organism process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;proteolysis;regulation of protein metabolic process;negative regulation of catalytic activity;nitrogen compound transport;organic substance metabolic process;macromolecule metabolic process;negative regulation of peptidase activity;biological regulation;organic substance transport;negative regulation of biological process;regulation of molecular function;regulation of biological quality;transport;regulation of peptidase activity;regulation of endopeptidase activity;thyroid hormone transport;regulation of hormone levels;single-organism transport;biological_process;negative regulation of endopeptidase activity;establishment of localization;negative regulation of hydrolase activity;localization;single-organism localization;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of catalytic activity;regulation of macromolecule metabolic process;cellular metabolic process;hormone transport;protein metabolic process;regulation of proteolysis;cellular process;negative regulation of cellular process; 3;3;3;4;4;4;6;2;2;6;2;4;5;5;4;4;5;5;5;5;3;4;7;2;5;2;3;3;4;6;7;6;4;4;1;8;3;6;2;3;5;3;5;5;4;4;3;5;4;6;2;3; GO:0043227;GO:0043226;GO:1903561;GO:0070062;GO:0005615;GO:0031982;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular vesicle;extracellular exosome;extracellular space;vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;3;4;3;4;3;1;2;2; GO:0030414;GO:0003674;GO:0098772;GO:0004857;GO:0061134;GO:0061135;GO:0030234;GO:0004866;GO:0004867; peptidase inhibitor activity;molecular_function;molecular function regulator;enzyme inhibitor activity;peptidase regulator activity;endopeptidase regulator activity;enzyme regulator activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity; 5;1;2;4;4;5;3;6;7; K20734 IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; extracellular Hs4507377 860.0 V [V] Defense mechanisms; P05546 Heparin cofactor 2 OS=Homo sapiens OX=9606 GN=SERPIND1 PE=1 SV=3 - [HEP2_HUMAN] 0.964 0.889 1.203 1.028 0.913 1.336 1.084364454 0.002180258 1.125958379 4.28E-13 1.353205849 3.05E-30 1.463307777 5.47E-22 GO:0007599;GO:0019222;GO:0007596;GO:0031324;GO:0045861;GO:0008152;GO:0050789;GO:0050790;GO:0009892;GO:0044699;GO:0080090;GO:0044267;GO:0051248;GO:0008218;GO:0010605;GO:0042330;GO:0051246;GO:0009611;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0065008;GO:0051336;GO:0032501;GO:0006935;GO:0050878;GO:0052547;GO:0052548;GO:0031323;GO:0042060;GO:0044260;GO:0006950;GO:0050817;GO:0008150;GO:0010951;GO:0042221;GO:0051346;GO:0006508;GO:0050794;GO:0040011;GO:0044238;GO:0032269;GO:0032268;GO:0009605;GO:0044707;GO:0060255;GO:0050896;GO:0044237;GO:0043170;GO:0019538;GO:0030162;GO:0009987;GO:0048523; hemostasis;regulation of metabolic process;blood coagulation;negative regulation of cellular metabolic process;negative regulation of proteolysis;metabolic process;regulation of biological process;regulation of catalytic activity;negative regulation of metabolic process;single-organism process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;bioluminescence;negative regulation of macromolecule metabolic process;taxis;regulation of protein metabolic process;response to wounding;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;regulation of biological quality;regulation of hydrolase activity;multicellular organismal process;chemotaxis;regulation of body fluid levels;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular metabolic process;wound healing;cellular macromolecule metabolic process;response to stress;coagulation;biological_process;negative regulation of endopeptidase activity;response to chemical;negative regulation of hydrolase activity;proteolysis;regulation of cellular process;locomotion;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;response to external stimulus;single-multicellular organism process;regulation of macromolecule metabolic process;response to stimulus;cellular metabolic process;macromolecule metabolic process;protein metabolic process;regulation of proteolysis;cellular process;negative regulation of cellular process; 5;3;5;4;6;2;2;4;3;2;4;5;5;4;4;3;5;4;5;3;7;2;4;2;3;3;5;2;4;4;6;7;4;5;4;3;4;1;8;3;6;5;3;2;3;5;5;3;3;4;2;3;4;4;6;2;3; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:1903561;GO:0031982;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;extracellular vesicle;vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;4;3;1;2;2; GO:0030414;GO:1901681;GO:0003674;GO:0005539;GO:0004857;GO:0098772;GO:0043168;GO:0097367;GO:0008201;GO:0061135;GO:0030234;GO:0061134;GO:0004866;GO:0004867;GO:0043167;GO:0005488; peptidase inhibitor activity;sulfur compound binding;molecular_function;glycosaminoglycan binding;enzyme inhibitor activity;molecular function regulator;anion binding;carbohydrate derivative binding;heparin binding;endopeptidase regulator activity;enzyme regulator activity;peptidase regulator activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;ion binding;binding; 5;3;1;4;4;2;4;3;4;5;3;4;6;7;3;2; K03912 map04610; Complement and coagulation cascades; IPR033831;IPR023795;IPR000215;IPR023796; Heparin cofactor II;Serpin, conserved site;Serpin family;Serpin domain; extracellular Hs4504355 1036.0 V [V] Defense mechanisms; Q04756 Hepatocyte growth factor activator OS=Homo sapiens OX=9606 GN=HGFAC PE=1 SV=1 - [HGFA_HUMAN] 0.855 0.947 1.166 0.992 0.877 0.969 0.902851109 0.486538848 1.131128848 0.939625696 1.2312566 0.059293645 1.104903079 0.904149206 GO:0071704;GO:0019538;GO:0043170;GO:0008152;GO:0006508;GO:0008150;GO:0044238; organic substance metabolic process;protein metabolic process;macromolecule metabolic process;metabolic process;proteolysis;biological_process;primary metabolic process; 3;4;4;2;5;1;3; GO:0005615;GO:0005576;GO:0005575;GO:0044421; extracellular space;extracellular region;cellular_component;extracellular region part; 3;2;1;2; GO:0004252;GO:0004175;GO:0017171;GO:0016787;GO:0003824;GO:0070011;GO:0003674;GO:0008233;GO:0008236; serine-type endopeptidase activity;endopeptidase activity;serine hydrolase activity;hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides;molecular_function;peptidase activity;serine-type peptidase activity; 6;6;4;3;2;5;1;4;5; K09631 IPR000001;IPR001254;IPR018056;IPR014394;IPR000083;IPR009003;IPR000742;IPR001314;IPR000562;IPR013806;IPR013032;IPR033116;IPR018114; Kringle;Serine proteases, trypsin domain;Kringle, conserved site;Coagulation factor XII/hepatocyte growth factor activator;Fibronectin, type I;Peptidase S1, PA clan;EGF-like domain;Peptidase S1A, chymotrypsin family;Fibronectin, type II, collagen-binding;Kringle-like fold;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular Hs4504383_1 758.0 T [T] Signal transduction mechanisms; Q9NQU5 Serine/threonine-protein kinase PAK 6 OS=Homo sapiens OX=9606 GN=PAK6 PE=1 SV=1 - [PAK6_HUMAN] 1.041 1.042 0.963 1.07 1.144 0.832 0.999040307 nan 0.935314685 nan 0.924184261 nan 0.727272727 nan GO:0019220;GO:0080090;GO:0019222;GO:0048583;GO:0032147;GO:0007165;GO:1901362;GO:0071840;GO:0051716;GO:0010604;GO:0009966;GO:0000165;GO:0043067;GO:0044093;GO:0048518;GO:0060255;GO:0045859;GO:2001141;GO:0046483;GO:0042325;GO:0044700;GO:0042327;GO:0048870;GO:0019538;GO:0033554;GO:0019438;GO:0009893;GO:0033674;GO:0023051;GO:0006928;GO:0006807;GO:0035556;GO:0050789;GO:0097659;GO:1901576;GO:0007346;GO:0051347;GO:0030029;GO:0044260;GO:0043549;GO:0016043;GO:0065007;GO:1901360;GO:0065009;GO:0016477;GO:0018130;GO:0043085;GO:0050790;GO:0009889;GO:0044710;GO:0050794;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0006355;GO:0010556;GO:0006351;GO:0010562;GO:0032774;GO:0016310;GO:0031098;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007266;GO:0010646;GO:0007049;GO:0043408;GO:0006139;GO:1902531;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0023014;GO:0040011;GO:0009987;GO:0006725;GO:1903506;GO:0044699;GO:0032268;GO:0051252;GO:0043170;GO:0051674;GO:0045860;GO:0031326;GO:0031325;GO:0031323;GO:0030036;GO:0090304;GO:0008219;GO:0010941;GO:0042981;GO:2000112;GO:1902589;GO:0071704;GO:0010467;GO:0010468;GO:0006468;GO:0000278;GO:0045937;GO:0044267;GO:0019219;GO:0006915;GO:0006464;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007154;GO:0007265;GO:0007264;GO:0051179;GO:0006996;GO:0044238;GO:0007010;GO:0051726;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of response to stimulus;activation of protein kinase activity;signal transduction;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of macromolecule metabolic process;regulation of signal transduction;MAPK cascade;regulation of programmed cell death;positive regulation of molecular function;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of protein kinase activity;regulation of RNA biosynthetic process;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;cell motility;protein metabolic process;cellular response to stress;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of kinase activity;regulation of signaling;movement of cell or subcellular component;nitrogen compound metabolic process;intracellular signal transduction;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;regulation of mitotic cell cycle;positive regulation of transferase activity;actin filament-based process;cellular macromolecule metabolic process;regulation of kinase activity;cellular component organization;biological regulation;organic cyclic compound metabolic process;regulation of molecular function;cell migration;heterocycle biosynthetic process;positive regulation of catalytic activity;regulation of catalytic activity;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of phosphorus metabolic process;RNA biosynthetic process;phosphorylation;stress-activated protein kinase signaling cascade;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;Rho protein signal transduction;regulation of cell communication;cell cycle;regulation of MAPK cascade;nucleobase-containing compound metabolic process;regulation of intracellular signal transduction;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;signal transduction by protein phosphorylation;locomotion;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;single-organism process;regulation of cellular protein metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;localization of cell;positive regulation of protein kinase activity;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;actin cytoskeleton organization;nucleic acid metabolic process;cell death;regulation of cell death;regulation of apoptotic process;regulation of cellular macromolecule biosynthetic process;single-organism organelle organization;organic substance metabolic process;gene expression;regulation of gene expression;protein phosphorylation;mitotic cell cycle;positive regulation of phosphate metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;localization;organelle organization;primary metabolic process;cytoskeleton organization;regulation of cell cycle;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;4;3;3;9;4;5;2;3;4;4;5;5;4;2;4;7;6;4;7;3;7;3;4;4;5;3;7;3;4;3;5;2;7;4;5;6;4;4;6;3;2;4;3;4;5;5;4;4;3;3;5;5;5;1;2;5;5;5;2;6;3;5;6;5;6;5;6;6;5;4;4;2;5;8;4;4;6;4;5;5;5;5;6;4;2;2;4;7;2;5;5;4;3;8;5;4;4;5;5;4;4;6;6;4;3;5;5;7;5;6;5;5;6;6;5;3;5;3;4;4;7;6;2;4;3;5;4;3;5;4;7;7;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasm;nucleus;cell part;cell;organelle;cellular_component; 4;3;3;3;3;4;5;2;2;2;1; GO:0031267;GO:1901363;GO:0004674;GO:0000166;GO:0016740;GO:0097367;GO:0003674;GO:0005488;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0016301;GO:0017016;GO:0036094;GO:0003824;GO:0016773;GO:0016772;GO:0048365;GO:0032559;GO:0032555;GO:0032553;GO:0035639;GO:0019899;GO:0043167;GO:0017048;GO:0030554;GO:0051020;GO:0005515;GO:0097159;GO:0001883;GO:0001882;GO:1901265;GO:0004672;GO:0032550; small GTPase binding;heterocyclic compound binding;protein serine/threonine kinase activity;nucleotide binding;transferase activity;carbohydrate derivative binding;molecular_function;binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;kinase activity;Ras GTPase binding;small molecule binding;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;Rac GTPase binding;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;enzyme binding;ion binding;Rho GTPase binding;adenyl nucleotide binding;GTPase binding;protein binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;nucleoside phosphate binding;protein kinase activity;purine ribonucleoside binding; 6;3;7;4;3;3;1;2;5;5;6;4;5;7;3;2;5;4;9;6;5;4;5;4;3;8;6;5;3;3;5;4;4;6;6; K05735 map04012;map04014;map04360;map04510;map04660;map04810;map05211; ErbB signaling pathway;Ras signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Renal cell carcinoma; IPR011009;IPR035066;IPR000719;IPR000095;IPR017441;IPR033923; Protein kinase-like domain;Serine/threonine-protein kinase PAK 6;Protein kinase domain;CRIB domain;Protein kinase, ATP binding site;p21 activated kinase binding domain; nucleus Hs9910476 1394.0 T [T] Signal transduction mechanisms; Q96C34 RUN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUNDC1 PE=1 SV=3 - [RUND1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan IPR004012; RUN domain; cytosol Hs20559125 1253.0 T [T] Signal transduction mechanisms; P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1 - [2ABA_HUMAN] 1.049 1.164 0.918 0.853 1.113 1.298 0.901202749 nan 0.766397125 nan 0.788659794 nan 1.16621743 nan GO:0019220;GO:0080090;GO:0019222;GO:0000086;GO:0006470;GO:0061024;GO:0034047;GO:1901360;GO:1901361;GO:0071840;GO:0010256;GO:0007084;GO:0060255;GO:0031468;GO:0010033;GO:0046483;GO:0019538;GO:0010243;GO:0006807;GO:0043170;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0016043;GO:0009719;GO:0065007;GO:0007049;GO:0065009;GO:0050790;GO:0046700;GO:0019439;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034655;GO:0035303;GO:0050794;GO:0035304;GO:0051336;GO:0016071;GO:0043666;GO:1901698;GO:0044802;GO:0016311;GO:0010921;GO:0044248;GO:0034641;GO:0014072;GO:0044699;GO:0006139;GO:0051246;GO:0031399;GO:0016070;GO:0006997;GO:0009987;GO:0006725;GO:0043278;GO:0043279;GO:0044270;GO:0090304;GO:0032268;GO:0000956;GO:0014070;GO:0050896;GO:0000184;GO:0044839;GO:0031323;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0006998;GO:0071704;GO:0010467;GO:0006401;GO:0006402;GO:0000278;GO:0006464;GO:0051174;GO:0044763;GO:0042221;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0044237;GO:0006796;GO:0006793; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;G2/M transition of mitotic cell cycle;protein dephosphorylation;membrane organization;regulation of protein phosphatase type 2A activity;organic cyclic compound metabolic process;organic cyclic compound catabolic process;cellular component organization or biogenesis;endomembrane system organization;mitotic nuclear envelope reassembly;regulation of macromolecule metabolic process;nuclear envelope reassembly;response to organic substance;heterocycle metabolic process;protein metabolic process;response to organonitrogen compound;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;cellular component organization;response to endogenous stimulus;biological regulation;cell cycle;regulation of molecular function;regulation of catalytic activity;heterocycle catabolic process;aromatic compound catabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound catabolic process;regulation of dephosphorylation;regulation of cellular process;regulation of protein dephosphorylation;regulation of hydrolase activity;mRNA metabolic process;regulation of phosphoprotein phosphatase activity;response to nitrogen compound;single-organism membrane organization;dephosphorylation;regulation of phosphatase activity;cellular catabolic process;cellular nitrogen compound metabolic process;response to isoquinoline alkaloid;single-organism process;nucleobase-containing compound metabolic process;regulation of protein metabolic process;regulation of protein modification process;RNA metabolic process;nucleus organization;cellular process;cellular aromatic compound metabolic process;response to morphine;response to alkaloid;cellular nitrogen compound catabolic process;nucleic acid metabolic process;regulation of cellular protein metabolic process;nuclear-transcribed mRNA catabolic process;response to organic cyclic compound;response to stimulus;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;cell cycle G2/M phase transition;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;nuclear envelope organization;organic substance metabolic process;gene expression;RNA catabolic process;mRNA catabolic process;mitotic cell cycle;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;response to chemical;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process; 6;4;3;6;7;4;8;4;5;2;4;6;4;6;4;4;4;4;3;4;2;5;4;5;4;3;3;2;4;3;4;5;5;5;5;1;2;5;7;3;7;5;6;7;4;4;6;6;4;4;6;2;4;5;6;5;5;2;4;7;5;5;5;5;8;5;2;9;6;4;5;5;6;4;5;3;5;6;7;5;6;5;3;3;3;5;4;3;3;5;4; GO:0031974;GO:0031981;GO:1902494;GO:0043234;GO:0000159;GO:0043233;GO:0005829;GO:0043231;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0008287;GO:0044464;GO:0005623;GO:0005622;GO:1903293;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;catalytic complex;protein complex;protein phosphatase type 2A complex;organelle lumen;cytosol;intracellular membrane-bounded organelle;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;protein serine/threonine phosphatase complex;cell part;cell;intracellular;phosphatase complex;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;5;4;4;3;2;3;3;5;3;4;4;5;3;2;2;3;5;2;2;1;4; GO:0098772;GO:0042578;GO:0003674;GO:0016787;GO:0019888;GO:0016788;GO:0003824;GO:0004722;GO:0004721;GO:0016791;GO:0019208;GO:0008601;GO:0030234; molecular function regulator;phosphoric ester hydrolase activity;molecular_function;hydrolase activity;protein phosphatase regulator activity;hydrolase activity, acting on ester bonds;catalytic activity;protein serine/threonine phosphatase activity;phosphoprotein phosphatase activity;phosphatase activity;phosphatase regulator activity;protein phosphatase type 2A regulator activity;enzyme regulator activity; 2;5;1;3;5;4;2;8;7;6;4;6;3; K04354 map03015;map04071;map04111;map04151;map04152;map04261;map04390;map04391;map04530;map04728;map05142;map05160; mRNA surveillance pathway;Sphingolipid signaling pathway;Cell cycle - yeast;PI3K-Akt signaling pathway;AMPK signaling pathway;Adrenergic signaling in cardiomyocytes;Hippo signaling pathway;Hippo signaling pathway - fly;Tight junction;Dopaminergic synapse;Chagas disease (American trypanosomiasis);Hepatitis C; IPR015943;IPR000009;IPR017986;IPR018067;IPR001680; WD40/YVTN repeat-like-containing domain;Protein phosphatase 2A regulatory subunit PR55;WD40-repeat-containing domain;Protein phosphatase 2A regulatory subunit PR55, conserved site;WD40 repeat; cytosol Hs4506019 936.0 T [T] Signal transduction mechanisms; P00751 Complement factor B OS=Homo sapiens OX=9606 GN=CFB PE=1 SV=2 - [CFAB_HUMAN] 1.002 0.89 1.171 1.011 0.893 0.988 1.125842697 1.34E-14 1.132138858 2.60E-24 1.315730337 3.15E-67 1.106382979 7.17E-16 GO:0006954;GO:0030449;GO:0080090;GO:0019222;GO:0032101;GO:0048584;GO:0048583;GO:0050727;GO:0002673;GO:0002920;GO:0030162;GO:0050789;GO:0031347;GO:0044710;GO:0072376;GO:0051246;GO:0009611;GO:0071704;GO:0010467;GO:0002682;GO:0044699;GO:0048518;GO:0065007;GO:1903034;GO:0010468;GO:0060255;GO:0045087;GO:2000257;GO:0006952;GO:0006950;GO:0050776;GO:0006956;GO:0006957;GO:0008152;GO:0006955;GO:0016485;GO:0002526;GO:0006959;GO:0006508;GO:0044238;GO:0070613;GO:0009605;GO:0051604;GO:0002684;GO:0019538;GO:0050896;GO:0050778;GO:0043170;GO:0002376;GO:0002697;GO:0002253;GO:0002252;GO:0008150;GO:1903317;GO:0080134; inflammatory response;regulation of complement activation;regulation of primary metabolic process;regulation of metabolic process;regulation of response to external stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of inflammatory response;regulation of acute inflammatory response;regulation of humoral immune response;regulation of proteolysis;regulation of biological process;regulation of defense response;single-organism metabolic process;protein activation cascade;regulation of protein metabolic process;response to wounding;organic substance metabolic process;gene expression;regulation of immune system process;single-organism process;positive regulation of biological process;biological regulation;regulation of response to wounding;regulation of gene expression;regulation of macromolecule metabolic process;innate immune response;regulation of protein activation cascade;defense response;response to stress;regulation of immune response;complement activation;complement activation, alternative pathway;metabolic process;immune response;protein processing;acute inflammatory response;humoral immune response;proteolysis;primary metabolic process;regulation of protein processing;response to external stimulus;protein maturation;positive regulation of immune system process;protein metabolic process;response to stimulus;positive regulation of immune response;macromolecule metabolic process;immune system process;regulation of immune effector process;activation of immune response;immune effector process;biological_process;regulation of protein maturation;regulation of response to stress; 5;5;4;3;4;3;3;5;6;5;6;2;5;3;3;5;4;3;5;3;2;2;2;5;5;4;4;4;4;3;4;4;5;2;3;6;6;4;5;3;7;3;5;3;4;2;4;4;2;4;3;3;1;6;4; GO:0044421;GO:0043227;GO:0005575;GO:1903561;GO:0070062;GO:0005615;GO:0016020;GO:0072562;GO:0043226;GO:0005576;GO:0005886;GO:0071944;GO:0031982;GO:0043230;GO:0044464;GO:0005623; extracellular region part;membrane-bounded organelle;cellular_component;extracellular vesicle;extracellular exosome;extracellular space;membrane;blood microparticle;organelle;extracellular region;plasma membrane;cell periphery;vesicle;extracellular organelle;cell part;cell; 2;3;1;3;4;3;2;3;2;2;3;3;4;3;2;2; GO:0004252;GO:0004175;GO:0003674;GO:0005488;GO:0008233;GO:0008236;GO:0016787;GO:0001848;GO:0005515;GO:0017171;GO:0003824;GO:0070011; serine-type endopeptidase activity;endopeptidase activity;molecular_function;binding;peptidase activity;serine-type peptidase activity;hydrolase activity;complement binding;protein binding;serine hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides; 6;6;1;2;4;5;3;4;3;4;2;5; K01335 map04610;map05150; Complement and coagulation cascades;Staphylococcus aureus infection; IPR002035;IPR000436;IPR009003;IPR001314;IPR028341;IPR001254;IPR033116;IPR011360;IPR018114; von Willebrand factor, type A;Sushi/SCR/CCP domain;Peptidase S1, PA clan;Peptidase S1A, chymotrypsin family;Complement factor B;Serine proteases, trypsin domain;Serine proteases, trypsin family, serine active site;Complement B/C2;Serine proteases, trypsin family, histidine active site; extracellular Hs4502397 1592.0 E [E] Amino acid transport and metabolism; Q14517 Protocadherin Fat 1 OS=Homo sapiens OX=9606 GN=FAT1 PE=1 SV=2 - [FAT1_HUMAN] 0.832 0.855 1.461 1.081 0.961 0.754 0.973099415 nan 1.124869927 nan 1.70877193 nan 0.784599376 nan GO:0016337;GO:0043933;GO:0048870;GO:0030036;GO:0006928;GO:0007267;GO:0007163;GO:0023052;GO:0007154;GO:0009653;GO:0071840;GO:0071822;GO:0016043;GO:0098609;GO:0022610;GO:0032502;GO:0040011;GO:0098602;GO:0030029;GO:0044700;GO:0009987;GO:0051674;GO:0016477;GO:0008150;GO:0007155;GO:0051179;GO:0098742;GO:0006996;GO:0007015;GO:0044699;GO:0007156;GO:0007010;GO:0048856;GO:1902589;GO:0044763; single organismal cell-cell adhesion;macromolecular complex subunit organization;cell motility;actin cytoskeleton organization;movement of cell or subcellular component;cell-cell signaling;establishment or maintenance of cell polarity;signaling;cell communication;anatomical structure morphogenesis;cellular component organization or biogenesis;protein complex subunit organization;cellular component organization;cell-cell adhesion;biological adhesion;developmental process;locomotion;single organism cell adhesion;actin filament-based process;single organism signaling;cellular process;localization of cell;cell migration;biological_process;cell adhesion;localization;cell-cell adhesion via plasma-membrane adhesion molecules;organelle organization;actin filament organization;single-organism process;homophilic cell adhesion via plasma membrane adhesion molecules;cytoskeleton organization;anatomical structure development;single-organism organelle organization;single-organism cellular process; 4;4;3;5;4;4;4;2;4;3;2;5;3;4;2;2;2;3;4;3;2;3;4;1;3;2;5;4;6;2;6;5;3;4;3; GO:0016021;GO:0005887;GO:0030175;GO:0043229;GO:0070161;GO:0005924;GO:0043227;GO:0043226;GO:0030055;GO:0005737;GO:0042995;GO:0070062;GO:0031226;GO:0005634;GO:0016020;GO:0044444;GO:0030054;GO:0044425;GO:0048471;GO:0044459;GO:0005925;GO:0030027;GO:0071944;GO:0031252;GO:0005912;GO:0005911;GO:0005886;GO:0043230;GO:1903561;GO:0031224;GO:0031982;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0098858;GO:0044424;GO:0044421; integral component of membrane;integral component of plasma membrane;filopodium;intracellular organelle;anchoring junction;cell-substrate adherens junction;membrane-bounded organelle;organelle;cell-substrate junction;cytoplasm;cell projection;extracellular exosome;intrinsic component of plasma membrane;nucleus;membrane;cytoplasmic part;cell junction;membrane part;perinuclear region of cytoplasm;plasma membrane part;focal adhesion;lamellipodium;cell periphery;cell leading edge;adherens junction;cell-cell junction;plasma membrane;extracellular organelle;extracellular vesicle;intrinsic component of membrane;vesicle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;extracellular region;actin-based cell projection;intracellular part;extracellular region part; 4;4;5;3;3;4;3;2;3;4;3;4;4;5;2;4;2;2;5;3;5;4;3;3;4;3;3;3;3;3;4;4;2;2;3;1;2;4;3;2; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding; 1;2;4;3;6;5; K16506 IPR002126;IPR000152;IPR018097;IPR020894;IPR000742;IPR001881;IPR013032;IPR015919;IPR001791;IPR013320; Cadherin;EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Cadherin conserved site;EGF-like domain;EGF-like calcium-binding domain;EGF-like, conserved site;Cadherin-like;Laminin G domain;Concanavalin A-like lectin/glucanase domain; extracellular Hs4885229 9425.0 T [T] Signal transduction mechanisms; Q9BYK8 Helicase with zinc finger domain 2 OS=Homo sapiens OX=9606 GN=HELZ2 PE=1 SV=6 - [HELZ2_HUMAN] 0.79 0.637 1.753 0.585 0.727 2.626 1.240188383 nan 0.804676754 nan 2.751962323 nan 3.612104539 nan GO:0080090;GO:0019222;GO:0044281;GO:1901362;GO:1901360;GO:0044710;GO:0010604;GO:0048518;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0006629;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0010557;GO:0006357;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0044255;GO:0051252;GO:0051254;GO:1902680;GO:0010628;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0006355;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;small molecule metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;lipid metabolic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;cellular lipid metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of transcription, DNA-templated;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;4;5;4;3;4;2;4;6;4;5;3;4;3;4;7;4;4;2;7;5;4;4;3;1;2;5;5;5;5;7;6;6;4;4;5;2;4;7;2;4;7;6;4;5;5;6;5;7;5;5;4;4;5;6;6;2;3;5;5;5;5;5;3;5;3;4;4;3;3;3; GO:0031974;GO:0031981;GO:0016020;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle lumen; 2;5;2;4;3;4;3;2;3;3;2;5;3;5;2;2;3;1;4; GO:1901363;GO:0003713;GO:0003712;GO:0000166;GO:0046872;GO:0000988;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0017076;GO:0005524;GO:0016787;GO:0043169;GO:0003824;GO:0030374;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0032549;GO:0043167;GO:0044822;GO:0030554;GO:0003723;GO:0001883;GO:0001882;GO:1901265;GO:0017111;GO:0036094; heterocyclic compound binding;transcription coactivator activity;transcription cofactor activity;nucleotide binding;metal ion binding;transcription factor activity, protein binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;purine nucleotide binding;ATP binding;hydrolase activity;cation binding;catalytic activity;ligand-dependent nuclear receptor transcription coactivator activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;ribonucleoside binding;ion binding;poly(A) RNA binding;adenyl nucleotide binding;RNA binding;purine nucleoside binding;nucleoside binding;nucleoside phosphate binding;nucleoside-triphosphatase activity;small molecule binding; 3;5;4;4;5;2;8;5;3;4;1;2;4;5;3;5;6;3;4;2;6;3;6;6;5;6;4;5;4;5;3;6;6;5;5;4;4;7;3; IPR013087;IPR012340;IPR022966;IPR031191;IPR027417; Zinc finger C2H2-type;Nucleic acid-binding, OB-fold;Ribonuclease II/R, conserved site;Helicase with zinc finger domain 2;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs14769950_2 1976.0 J [J] Translation, ribosomal structure and biogenesis; P07195 L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2 - [LDHB_HUMAN] 1.025 1.095 0.871 1.092 1.03 1.408 0.936073059 0.53058645 1.060194175 0.269338579 0.79543379 0.011538681 1.366990291 0.195032857 GO:0019674;GO:0006732;GO:0006733;GO:0009117;GO:0019752;GO:1901564;GO:0034641;GO:0006807;GO:0046496;GO:1901615;GO:1901360;GO:0006139;GO:0044710;GO:0051186;GO:0019362;GO:0072524;GO:0071704;GO:0044699;GO:0046483;GO:0009987;GO:0006725;GO:0032787;GO:0019637;GO:0008150;GO:0008152;GO:0043436;GO:0055086;GO:0044238;GO:0006753;GO:0005975;GO:0006082;GO:0006089;GO:0044763;GO:0006796;GO:0006793;GO:0044237;GO:0006090;GO:0044281; NAD metabolic process;coenzyme metabolic process;oxidoreduction coenzyme metabolic process;nucleotide metabolic process;carboxylic acid metabolic process;organonitrogen compound metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;nicotinamide nucleotide metabolic process;organic hydroxy compound metabolic process;organic cyclic compound metabolic process;nucleobase-containing compound metabolic process;single-organism metabolic process;cofactor metabolic process;pyridine nucleotide metabolic process;pyridine-containing compound metabolic process;organic substance metabolic process;single-organism process;heterocycle metabolic process;cellular process;cellular aromatic compound metabolic process;monocarboxylic acid metabolic process;organophosphate metabolic process;biological_process;metabolic process;oxoacid metabolic process;nucleobase-containing small molecule metabolic process;primary metabolic process;nucleoside phosphate metabolic process;carbohydrate metabolic process;organic acid metabolic process;lactate metabolic process;single-organism cellular process;phosphate-containing compound metabolic process;phosphorus metabolic process;cellular metabolic process;pyruvate metabolic process;small molecule metabolic process; 8;5;6;6;6;4;4;3;7;4;4;4;3;4;6;5;3;2;4;2;4;7;4;1;2;5;4;3;5;4;4;5;3;5;4;3;8;4; GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0043209;GO:0098805;GO:0016020;GO:0044444;GO:0005739;GO:0043229;GO:0098589;GO:0043230;GO:1903561;GO:0031982;GO:0043231;GO:0005829;GO:0045121;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044425;GO:0098857;GO:0044421; membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;myelin sheath;whole membrane;membrane;cytoplasmic part;mitochondrion;intracellular organelle;membrane region;extracellular organelle;extracellular vesicle;vesicle;intracellular membrane-bounded organelle;cytosol;membrane raft;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;membrane part;membrane microdomain;extracellular region part; 3;2;4;4;3;3;2;4;5;3;3;3;3;4;4;5;5;2;2;3;1;2;3;2;4;2; GO:0005488;GO:0003674;GO:0016614;GO:0016491;GO:0004459;GO:0000166;GO:0051287;GO:0050662;GO:1901265;GO:0036094;GO:0003824;GO:0048037;GO:0097159;GO:0016616;GO:0004457;GO:1901363; binding;molecular_function;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity;L-lactate dehydrogenase activity;nucleotide binding;NAD binding;coenzyme binding;nucleoside phosphate binding;small molecule binding;catalytic activity;cofactor binding;organic cyclic compound binding;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;lactate dehydrogenase activity;heterocyclic compound binding; 2;1;4;3;6;4;5;4;4;3;2;3;3;5;5;3; K00016 map00010;map00270;map00620;map00640;map01100;map01110;map01120;map01130;map04922; Glycolysis / Gluconeogenesis;Cysteine and methionine metabolism;Pyruvate metabolism;Propanoate metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Glucagon signaling pathway; IPR001236;IPR011304;IPR018177;IPR015955;IPR001557;IPR022383;IPR016040; Lactate/malate dehydrogenase, N-terminal;L-lactate dehydrogenase;L-lactate dehydrogenase, active site;Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal;L-lactate/malate dehydrogenase;Lactate/malate dehydrogenase, C-terminal;NAD(P)-binding domain; cytosol Hs4557032 681.0 C [C] Energy production and conversion; P58317 Zinc finger protein 121 OS=Homo sapiens OX=9606 GN=ZNF121 PE=3 SV=2 - [ZN121_HUMAN] 2.225 0.459 0.71 1.438 0.486 0.652 4.847494553 nan 2.958847737 nan 1.546840959 nan 1.341563786 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:0043170;GO:1901360;GO:0032774;GO:1901576;GO:0044260;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0060255;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0051252;GO:0006355;GO:0010556;GO:0006351;GO:0019438;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of macromolecule metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of RNA metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process; 4;3;5;4;5;4;4;3;5;4;4;6;4;4;5;6;2;3;5;2;7;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;5;6;5;6;5;3; GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 3;2;5;4;2;3;2;3;1;3; GO:0043169;GO:0003674;GO:0001071;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0003700;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;nucleic acid binding transcription factor activity;DNA binding;metal ion binding;nucleic acid binding;ion binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;2;5;5;4;3;3;3;3;2; IPR013087;IPR013083; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type; nucleus Hs20486099 483.0 R [R] General function prediction only; P07196 Neurofilament light polypeptide OS=Homo sapiens OX=9606 GN=NEFL PE=1 SV=3 - [NFL_HUMAN] 1.218 1.058 0.696 1.197 1 1.379 1.151228733 nan 1.197 nan 0.657844991 nan 1.379 nan GO:0048468;GO:0048678;GO:0043523;GO:0043524;GO:0008088;GO:0051654;GO:0051656;GO:0031344;GO:0071840;GO:0031346;GO:0051402;GO:0051716;GO:0048869;GO:0009611;GO:0045664;GO:0045666;GO:0010720;GO:0048518;GO:0048519;GO:0031103;GO:0031102;GO:0060548;GO:0010970;GO:0010976;GO:0010975;GO:0003008;GO:0045109;GO:0044707;GO:0045104;GO:0051094;GO:0045103;GO:0033554;GO:0032536;GO:0032535;GO:0022604;GO:0022607;GO:0022603;GO:0006928;GO:0033693;GO:0031175;GO:0042981;GO:0050789;GO:0000904;GO:0000902;GO:0014012;GO:0070997;GO:0016043;GO:0090066;GO:0065007;GO:0065008;GO:0051130;GO:0061564;GO:0050767;GO:0050793;GO:0006810;GO:0050794;GO:0012501;GO:0006950;GO:0008150;GO:0051239;GO:0010770;GO:1901214;GO:0051234;GO:0008089;GO:0008090;GO:0046907;GO:0050896;GO:0072384;GO:0051962;GO:0048812;GO:0019896;GO:0030154;GO:0051128;GO:0034643;GO:0048523;GO:0051960;GO:0009653;GO:0044699;GO:0050769;GO:1901215;GO:0050885;GO:0051240;GO:0047497;GO:0031099;GO:0060284;GO:0030705;GO:0043933;GO:0010769;GO:0051640;GO:0032502;GO:0040011;GO:0032501;GO:0050877;GO:0009987;GO:0045597;GO:0045595;GO:0007409;GO:0007010;GO:0032990;GO:0050770;GO:0050772;GO:0048731;GO:0030030;GO:0031133;GO:0050905;GO:0008219;GO:0010941;GO:0007275;GO:0071822;GO:0043067;GO:0060052;GO:0043069;GO:0048666;GO:0048667;GO:0030182;GO:0006915;GO:0043066;GO:0044767;GO:0044765;GO:0045110;GO:0044763;GO:0051649;GO:0051646;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0048699;GO:0007017;GO:0048858;GO:0007399;GO:0048856;GO:0007018;GO:1902589;GO:0044085;GO:2000026;GO:0032989;GO:1902582;GO:1902580;GO:0000226;GO:0048522; cell development;response to axon injury;regulation of neuron apoptotic process;negative regulation of neuron apoptotic process;axo-dendritic transport;establishment of mitochondrion localization;establishment of organelle localization;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;neuron apoptotic process;cellular response to stimulus;cellular developmental process;response to wounding;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;axon regeneration;neuron projection regeneration;negative regulation of cell death;establishment of localization by movement along microtubule;positive regulation of neuron projection development;regulation of neuron projection development;system process;intermediate filament organization;single-multicellular organism process;intermediate filament cytoskeleton organization;positive regulation of developmental process;intermediate filament-based process;cellular response to stress;regulation of cell projection size;regulation of cellular component size;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;neurofilament bundle assembly;neuron projection development;regulation of apoptotic process;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;peripheral nervous system axon regeneration;neuron death;cellular component organization;regulation of anatomical structure size;biological regulation;regulation of biological quality;positive regulation of cellular component organization;axon development;regulation of neurogenesis;regulation of developmental process;transport;regulation of cellular process;programmed cell death;response to stress;biological_process;regulation of multicellular organismal process;positive regulation of cell morphogenesis involved in differentiation;regulation of neuron death;establishment of localization;anterograde axonal transport;retrograde axonal transport;intracellular transport;response to stimulus;organelle transport along microtubule;positive regulation of nervous system development;neuron projection morphogenesis;axon transport of mitochondrion;cell differentiation;regulation of cellular component organization;establishment of mitochondrion localization, microtubule-mediated;negative regulation of cellular process;regulation of nervous system development;anatomical structure morphogenesis;single-organism process;positive regulation of neurogenesis;negative regulation of neuron death;neuromuscular process controlling balance;positive regulation of multicellular organismal process;mitochondrion transport along microtubule;regeneration;regulation of cell development;cytoskeleton-dependent intracellular transport;macromolecular complex subunit organization;regulation of cell morphogenesis involved in differentiation;organelle localization;developmental process;locomotion;multicellular organismal process;neurological system process;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;axonogenesis;cytoskeleton organization;cell part morphogenesis;regulation of axonogenesis;positive regulation of axonogenesis;system development;cell projection organization;regulation of axon diameter;neuromuscular process;cell death;regulation of cell death;multicellular organism development;protein complex subunit organization;regulation of programmed cell death;neurofilament cytoskeleton organization;negative regulation of programmed cell death;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;apoptotic process;negative regulation of apoptotic process;single-organism developmental process;single-organism transport;intermediate filament bundle assembly;single-organism cellular process;establishment of localization in cell;mitochondrion localization;neurogenesis;localization;single-organism localization;cellular localization;organelle organization;generation of neurons;microtubule-based process;cell projection morphogenesis;nervous system development;anatomical structure development;microtubule-based movement;single-organism organelle organization;cellular component biogenesis;regulation of multicellular organismal development;cellular component morphogenesis;single-organism intracellular transport;single-organism cellular localization;microtubule cytoskeleton organization;positive regulation of cellular process; 4;5;6;6;5;5;4;5;2;5;6;3;4;4;7;6;5;2;2;6;5;4;4;6;6;3;6;3;5;3;4;4;5;4;5;4;4;4;6;5;6;2;5;5;7;5;3;4;2;3;4;6;6;3;4;3;5;3;1;3;5;5;3;6;6;5;2;5;4;6;6;5;4;5;3;5;3;2;5;5;6;3;6;4;5;6;4;6;4;2;2;2;4;2;4;4;7;5;5;7;6;4;4;6;5;4;4;4;5;5;6;5;5;6;6;6;6;3;4;5;3;4;5;6;2;3;3;4;7;4;5;5;3;5;4;3;4;4;5;4;5;3; GO:0099512;GO:0099513;GO:0030424;GO:0043209;GO:0005882;GO:0042995;GO:0043234;GO:0005829;GO:0044424;GO:0043232;GO:0043229;GO:0043228;GO:0005856;GO:0045111;GO:0044430;GO:0005883;GO:0044446;GO:0044444;GO:0044422;GO:0033596;GO:0005737;GO:0043005;GO:0044464;GO:0005623;GO:0005622;GO:0097458;GO:0044445;GO:0032991;GO:0005575;GO:0043226; supramolecular fiber;polymeric cytoskeletal fiber;axon;myelin sheath;intermediate filament;cell projection;protein complex;cytosol;intracellular part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;intermediate filament cytoskeleton;cytoskeletal part;neurofilament;intracellular organelle part;cytoplasmic part;organelle part;TSC1-TSC2 complex;cytoplasm;neuron projection;cell part;cell;intracellular;neuron part;cytosolic part;macromolecular complex;cellular_component;organelle; 2;3;5;3;4;3;3;5;3;4;3;3;5;6;4;5;3;4;2;4;4;4;2;2;3;3;5;2;1;2; GO:0003674;GO:0005200;GO:0005198; molecular_function;structural constituent of cytoskeleton;structural molecule activity; 1;3;2; K04572 map05014; Amyotrophic lateral sclerosis (ALS); IPR001664;IPR006821;IPR027692;IPR018039; Intermediate filament protein;Intermediate filament head, DNA-binding domain;Neurofilament light polypeptide;Intermediate filament protein, conserved site; nucleus A6NHP3 Speedy protein E2B OS=Homo sapiens OX=9606 GN=SPDYE2B PE=3 SV=2 - [SPE2B_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0019220;GO:0080090;GO:0019222;GO:0016310;GO:0031323;GO:0050789;GO:0044267;GO:0044260;GO:0043549;GO:0051246;GO:0071704;GO:0065007;GO:0031399;GO:0065009;GO:0006468;GO:0009987;GO:0044238;GO:0060255;GO:0045859;GO:0006464;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0042325;GO:0051174;GO:0032268;GO:0050790;GO:0019538;GO:0051338;GO:0043170;GO:0006796;GO:0006793;GO:0044237;GO:0001932; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;phosphorylation;regulation of cellular metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;regulation of protein metabolic process;organic substance metabolic process;biological regulation;regulation of protein modification process;regulation of molecular function;protein phosphorylation;cellular process;primary metabolic process;regulation of macromolecule metabolic process;regulation of protein kinase activity;cellular protein modification process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of phosphorylation;regulation of phosphorus metabolic process;regulation of cellular protein metabolic process;regulation of catalytic activity;protein metabolic process;regulation of transferase activity;macromolecule metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;cellular metabolic process;regulation of protein phosphorylation; 6;4;3;6;4;2;5;4;6;5;3;2;6;3;7;2;3;4;7;6;3;5;5;1;2;7;5;5;4;4;5;4;5;4;3;7; GO:0019899;GO:0003674;GO:0005488;GO:0019901;GO:0019900;GO:0005515; enzyme binding;molecular_function;binding;protein kinase binding;kinase binding;protein binding; 4;1;2;6;5;3; K08694 map04114;map04914; Oocyte meiosis;Progesterone-mediated oocyte maturation; IPR020984; Cell cycle regulatory protein Speedy; nucleus Q07954 Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2 - [LRP1_HUMAN] 1.032 1.119 0.805 1.46 0.802 1.277 0.922252011 0.38468318 1.820448878 0.092088342 0.719392315 0.088704182 1.592269327 0.184625534 GO:0006775;GO:0006909;GO:0051049;GO:0043277;GO:0048583;GO:0030111;GO:0008104;GO:0043524;GO:0044281;GO:0007166;GO:0007167;GO:0007169;GO:0031345;GO:0010648;GO:0044710;GO:0071704;GO:0048869;GO:0051493;GO:0033043;GO:0045664;GO:0048513;GO:0048514;GO:0010721;GO:0048518;GO:0016101;GO:0033036;GO:0048585;GO:0048699;GO:0006766;GO:0051050;GO:0032429;GO:0060548;GO:0007603;GO:0007602;GO:0045184;GO:0032373;GO:0010977;GO:0010975;GO:2000586;GO:0010876;GO:0065009;GO:0010874;GO:0044700;GO:0016477;GO:0016192;GO:0044707;GO:0019538;GO:0007186;GO:0016055;GO:0007205;GO:0072359;GO:0060322;GO:0007165;GO:0021537;GO:0015918;GO:0015850;GO:0014812;GO:0006928;GO:0044872;GO:0042157;GO:0031175;GO:0051222;GO:0042981;GO:0050789;GO:0009605;GO:0010646;GO:0030182;GO:0070997;GO:0001568;GO:0016043;GO:0031344;GO:0065007;GO:0071840;GO:0097242;GO:0032970;GO:0007417;GO:0035904;GO:0070201;GO:0006810;GO:0045665;GO:0006629;GO:0050767;GO:0050793;GO:0051716;GO:0048468;GO:0050794;GO:0051128;GO:0012501;GO:0008150;GO:0008152;GO:0032956;GO:0060284;GO:0009581;GO:1901214;GO:1901215;GO:0051336;GO:0044767;GO:0006897;GO:0007420;GO:0032368;GO:0021543;GO:0050896;GO:0006898;GO:0051402;GO:0009966;GO:0051960;GO:2000145;GO:0009416;GO:0032374;GO:0060191;GO:0035909;GO:0048870;GO:0006869;GO:0009314;GO:0030154;GO:0051129;GO:0030301;GO:0023057;GO:0023052;GO:0023051;GO:1904951;GO:0010640;GO:0044699;GO:0032880;GO:0072358;GO:0051234;GO:0009653;GO:0051241;GO:0032371;GO:0032370;GO:0050768;GO:0009583;GO:0050790;GO:0010875;GO:0032502;GO:0006996;GO:0032501;GO:0030178;GO:0008283;GO:0006721;GO:0006720;GO:2000146;GO:0009987;GO:0051271;GO:0045595;GO:0051270;GO:0048519;GO:0021987;GO:0051606;GO:0044255;GO:0032879;GO:0009628;GO:0051093;GO:0007568;GO:0048008;GO:0051239;GO:0051674;GO:0048731;GO:0035791;GO:0001944;GO:0030030;GO:0014910;GO:0014912;GO:0030036;GO:0043170;GO:0014909;GO:0008219;GO:0010941;GO:0001523;GO:0051223;GO:0042953;GO:0051961;GO:0007275;GO:0043067;GO:0043066;GO:0071702;GO:2000026;GO:0043069;GO:0048666;GO:0030336;GO:0009582;GO:0030334;GO:0009584;GO:0030029;GO:0006915;GO:0043523;GO:0044765;GO:0044763;GO:0007154;GO:0022008;GO:0009968;GO:0051179;GO:1902578;GO:0040011;GO:0044238;GO:0040013;GO:0040012;GO:0007010;GO:0007399;GO:0045596;GO:0060840;GO:0048856;GO:0044237;GO:1902589;GO:0033344;GO:0030900;GO:0010517;GO:2000587;GO:0015031;GO:0032376;GO:0010642;GO:0048844;GO:0048523; fat-soluble vitamin metabolic process;phagocytosis;regulation of transport;apoptotic cell clearance;regulation of response to stimulus;regulation of Wnt signaling pathway;protein localization;negative regulation of neuron apoptotic process;small molecule metabolic process;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of cell projection organization;negative regulation of cell communication;single-organism metabolic process;organic substance metabolic process;cellular developmental process;regulation of cytoskeleton organization;regulation of organelle organization;regulation of neuron differentiation;animal organ development;blood vessel morphogenesis;negative regulation of cell development;positive regulation of biological process;diterpenoid metabolic process;macromolecule localization;negative regulation of response to stimulus;generation of neurons;vitamin metabolic process;positive regulation of transport;regulation of phospholipase A2 activity;negative regulation of cell death;phototransduction, visible light;phototransduction;establishment of protein localization;positive regulation of sterol transport;negative regulation of neuron projection development;regulation of neuron projection development;regulation of platelet-derived growth factor receptor-beta signaling pathway;lipid localization;regulation of molecular function;regulation of cholesterol efflux;single organism signaling;cell migration;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;G-protein coupled receptor signaling pathway;Wnt signaling pathway;protein kinase C-activating G-protein coupled receptor signaling pathway;circulatory system development;head development;signal transduction;telencephalon development;sterol transport;organic hydroxy compound transport;muscle cell migration;movement of cell or subcellular component;lipoprotein localization;lipoprotein metabolic process;neuron projection development;positive regulation of protein transport;regulation of apoptotic process;regulation of biological process;response to external stimulus;regulation of cell communication;neuron differentiation;neuron death;blood vessel development;cellular component organization;regulation of cell projection organization;biological regulation;cellular component organization or biogenesis;beta-amyloid clearance;regulation of actin filament-based process;central nervous system development;aorta development;regulation of establishment of protein localization;transport;negative regulation of neuron differentiation;lipid metabolic process;regulation of neurogenesis;regulation of developmental process;cellular response to stimulus;cell development;regulation of cellular process;regulation of cellular component organization;programmed cell death;biological_process;metabolic process;regulation of actin cytoskeleton organization;regulation of cell development;detection of external stimulus;regulation of neuron death;negative regulation of neuron death;regulation of hydrolase activity;single-organism developmental process;endocytosis;brain development;regulation of lipid transport;pallium development;response to stimulus;receptor-mediated endocytosis;neuron apoptotic process;regulation of signal transduction;regulation of nervous system development;regulation of cell motility;response to light stimulus;regulation of cholesterol transport;regulation of lipase activity;aorta morphogenesis;cell motility;lipid transport;response to radiation;cell differentiation;negative regulation of cellular component organization;cholesterol transport;negative regulation of signaling;signaling;regulation of signaling;positive regulation of establishment of protein localization;regulation of platelet-derived growth factor receptor signaling pathway;single-organism process;regulation of protein localization;cardiovascular system development;establishment of localization;anatomical structure morphogenesis;negative regulation of multicellular organismal process;regulation of sterol transport;positive regulation of lipid transport;negative regulation of neurogenesis;detection of light stimulus;regulation of catalytic activity;positive regulation of cholesterol efflux;developmental process;organelle organization;multicellular organismal process;negative regulation of Wnt signaling pathway;cell proliferation;terpenoid metabolic process;isoprenoid metabolic process;negative regulation of cell motility;cellular process;negative regulation of cellular component movement;regulation of cell differentiation;regulation of cellular component movement;negative regulation of biological process;cerebral cortex development;detection of stimulus;cellular lipid metabolic process;regulation of localization;response to abiotic stimulus;negative regulation of developmental process;aging;platelet-derived growth factor receptor signaling pathway;regulation of multicellular organismal process;localization of cell;system development;platelet-derived growth factor receptor-beta signaling pathway;vasculature development;cell projection organization;regulation of smooth muscle cell migration;negative regulation of smooth muscle cell migration;actin cytoskeleton organization;macromolecule metabolic process;smooth muscle cell migration;cell death;regulation of cell death;retinoid metabolic process;regulation of protein transport;lipoprotein transport;negative regulation of nervous system development;multicellular organism development;regulation of programmed cell death;negative regulation of apoptotic process;organic substance transport;regulation of multicellular organismal development;negative regulation of programmed cell death;neuron development;negative regulation of cell migration;detection of abiotic stimulus;regulation of cell migration;detection of visible light;actin filament-based process;apoptotic process;regulation of neuron apoptotic process;single-organism transport;single-organism cellular process;cell communication;neurogenesis;negative regulation of signal transduction;localization;single-organism localization;locomotion;primary metabolic process;negative regulation of locomotion;regulation of locomotion;cytoskeleton organization;nervous system development;negative regulation of cell differentiation;artery development;anatomical structure development;cellular metabolic process;single-organism organelle organization;cholesterol efflux;forebrain development;regulation of phospholipase activity;negative regulation of platelet-derived growth factor receptor-beta signaling pathway;protein transport;positive regulation of cholesterol transport;negative regulation of platelet-derived growth factor receptor signaling pathway;artery morphogenesis;negative regulation of cellular process; 6;5;4;6;3;5;4;6;4;5;6;7;5;4;3;3;4;6;5;7;4;4;5;2;7;3;3;7;5;3;8;4;6;5;4;5;6;6;6;4;3;8;3;4;5;3;4;5;6;6;5;4;4;4;6;5;5;4;5;5;5;4;6;2;3;4;6;5;4;3;5;2;2;4;4;5;6;5;4;6;4;6;3;3;4;3;4;5;1;2;5;5;4;5;5;5;3;6;4;5;4;2;7;6;4;5;4;5;7;6;6;3;5;4;5;4;7;3;2;3;3;5;2;4;5;3;3;3;6;4;5;5;4;7;2;4;2;5;3;6;5;4;2;4;4;4;2;4;3;4;3;3;3;4;8;3;3;4;9;5;4;6;6;5;4;6;4;4;8;5;5;4;4;5;6;5;4;5;5;5;4;5;6;4;6;6;4;3;4;6;4;2;3;2;3;3;3;5;5;4;5;3;3;4;8;4;7;6;5;6;5;5;3; GO:0031974;GO:0030425;GO:0030054;GO:0030055;GO:0031982;GO:0031981;GO:0016023;GO:0016021;GO:0016020;GO:0098852;GO:0031988;GO:0098588;GO:0098589;GO:0044297;GO:0036477;GO:0042995;GO:0043231;GO:0043234;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0043232;GO:0043229;GO:0043228;GO:0005925;GO:0044433;GO:0044437;GO:0043025;GO:0070161;GO:0071944;GO:0030666;GO:0012505;GO:0031224;GO:0044446;GO:0044444;GO:0097708;GO:0000323;GO:0012506;GO:0043226;GO:0005905;GO:0031226;GO:0005737;GO:0031090;GO:0005924;GO:0005730;GO:0031410;GO:0005634;GO:0005773;GO:0043005;GO:0044459;GO:0030659;GO:0005912;GO:0005768;GO:0005774;GO:0044464;GO:0005623;GO:0005622;GO:0030139;GO:0032991;GO:0030135;GO:0030136;GO:0005764;GO:0005765;GO:0043227;GO:0098805;GO:0097458;GO:0005887;GO:0005886;GO:0005575;GO:0070013;GO:0043235; membrane-enclosed lumen;dendrite;cell junction;cell-substrate junction;vesicle;nuclear lumen;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;lytic vacuole membrane;membrane-bounded vesicle;bounding membrane of organelle;membrane region;cell body;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;protein complex;organelle lumen;nuclear part;intracellular part;membrane part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;focal adhesion;cytoplasmic vesicle part;vacuolar part;neuronal cell body;anchoring junction;cell periphery;endocytic vesicle membrane;endomembrane system;intrinsic component of membrane;intracellular organelle part;cytoplasmic part;intracellular vesicle;lytic vacuole;vesicle membrane;organelle;coated pit;intrinsic component of plasma membrane;cytoplasm;organelle membrane;cell-substrate adherens junction;nucleolus;cytoplasmic vesicle;nucleus;vacuole;neuron projection;plasma membrane part;cytoplasmic vesicle membrane;adherens junction;endosome;vacuolar membrane;cell part;cell;intracellular;endocytic vesicle;macromolecular complex;coated vesicle;clathrin-coated vesicle;lysosome;lysosomal membrane;membrane-bounded organelle;whole membrane;neuron part;integral component of plasma membrane;plasma membrane;cellular_component;intracellular organelle lumen;receptor complex; 2;5;2;3;4;5;5;4;2;5;5;4;3;3;4;3;4;3;3;4;3;2;2;4;3;3;5;4;4;4;3;3;4;3;3;3;4;4;6;4;2;3;4;4;3;4;5;5;5;5;4;3;5;4;4;4;2;2;3;6;2;6;7;7;6;3;3;3;4;3;1;4;4; GO:0060089;GO:1901363;GO:0044877;GO:0003674;GO:0003676;GO:0022892;GO:0097159;GO:0043169;GO:0043167;GO:0005509;GO:0032403;GO:0034185;GO:0046872;GO:0003723;GO:0005515;GO:0005102;GO:0042954;GO:0005488;GO:0004872;GO:0005215;GO:0008565;GO:0044822;GO:0070325; molecular transducer activity;heterocyclic compound binding;macromolecular complex binding;molecular_function;nucleic acid binding;substrate-specific transporter activity;organic cyclic compound binding;cation binding;ion binding;calcium ion binding;protein complex binding;apolipoprotein binding;metal ion binding;RNA binding;protein binding;receptor binding;lipoprotein transporter activity;binding;receptor activity;transporter activity;protein transporter activity;poly(A) RNA binding;lipoprotein particle receptor binding; 2;3;3;1;4;3;3;4;3;6;4;4;5;5;3;4;5;2;3;2;4;6;5; K04550 map05010;map05144; Alzheimer's disease;Malaria; IPR000152;IPR023415;IPR009030;IPR018097;IPR032485;IPR011042;IPR000742;IPR000033;IPR002172;IPR026823;IPR001881;IPR013032; EGF-type aspartate/asparagine hydroxylation site;Low-density lipoprotein (LDL) receptor class A, conserved site;Growth factor receptor cysteine-rich domain;EGF-like calcium-binding, conserved site;Domain of unknown function DUF5050;Six-bladed beta-propeller, TolB-like;EGF-like domain;LDLR class B repeat;Low-density lipoprotein (LDL) receptor class A repeat;Complement Clr-like EGF domain;EGF-like calcium-binding domain;EGF-like, conserved site; plasma membrane Hs4758686 9396.0 T [T] Signal transduction mechanisms; O43423 Acidic leucine-rich nuclear phosphoprotein 32 family member C OS=Homo sapiens OX=9606 GN=ANP32C PE=2 SV=1 - [AN32C_HUMAN] 0.784 0.821 1.676 0.773 0.985 0.89 0.954933009 0.863788561 0.784771574 0.066787772 2.041412911 2.91E-07 0.903553299 0.561914389 K18646 IPR001611;IPR032675; Leucine-rich repeat;Leucine-rich repeat domain, L domain-like; cytosol Hs6912604 452.0 DR [D] Cell cycle control, cell division, chromosome partitioning;[R] General function prediction only; Q9P2W7 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 OS=Homo sapiens OX=9606 GN=B3GAT1 PE=1 SV=2 - [B3GA1_HUMAN] 0.854 1 1.142 0.741 1.198 1.489 0.854 0.381075837 0.618530885 0.086058068 1.142 0.615777131 1.242904841 0.333789935 GO:1901566;GO:0030204;GO:0030203;GO:1903510;GO:0044249;GO:0006807;GO:0044281;GO:0034645;GO:1901137;GO:0009100;GO:0009101;GO:0044699;GO:0044723;GO:0044267;GO:0044710;GO:0044260;GO:0050650;GO:0071704;GO:0006024;GO:0036211;GO:0006023;GO:0044711;GO:1901576;GO:0009987;GO:0070085;GO:0006464;GO:0030166;GO:0043412;GO:0043413;GO:0044763;GO:0008152;GO:0043436;GO:0005975;GO:0009059;GO:0044238;GO:1901564;GO:0006486;GO:0006082;GO:0019538;GO:1901135;GO:0044272;GO:0009058;GO:0044237;GO:0043170;GO:0050654;GO:0006029;GO:0006790;GO:0006022;GO:0008150; organonitrogen compound biosynthetic process;chondroitin sulfate metabolic process;glycosaminoglycan metabolic process;mucopolysaccharide metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;small molecule metabolic process;cellular macromolecule biosynthetic process;carbohydrate derivative biosynthetic process;glycoprotein metabolic process;glycoprotein biosynthetic process;single-organism process;single-organism carbohydrate metabolic process;cellular protein metabolic process;single-organism metabolic process;cellular macromolecule metabolic process;chondroitin sulfate proteoglycan biosynthetic process;organic substance metabolic process;glycosaminoglycan biosynthetic process;protein modification process;aminoglycan biosynthetic process;single-organism biosynthetic process;organic substance biosynthetic process;cellular process;glycosylation;cellular protein modification process;proteoglycan biosynthetic process;macromolecule modification;macromolecule glycosylation;single-organism cellular process;metabolic process;oxoacid metabolic process;carbohydrate metabolic process;macromolecule biosynthetic process;primary metabolic process;organonitrogen compound metabolic process;protein glycosylation;organic acid metabolic process;protein metabolic process;carbohydrate derivative metabolic process;sulfur compound biosynthetic process;biosynthetic process;cellular metabolic process;macromolecule metabolic process;chondroitin sulfate proteoglycan metabolic process;proteoglycan metabolic process;sulfur compound metabolic process;aminoglycan metabolic process;biological_process; 5;5;6;7;4;3;4;5;5;5;6;2;4;5;3;4;6;3;6;5;5;4;4;2;5;6;7;5;6;3;2;5;4;5;3;4;4;4;4;4;5;3;3;4;5;6;4;5;1; GO:0043229;GO:0000139;GO:0005737;GO:0005623;GO:0043227;GO:0016021;GO:0016020;GO:0043226;GO:0044431;GO:0031224;GO:0005794;GO:0005622;GO:0098588;GO:0044446;GO:0044424;GO:0012505;GO:0044425;GO:0043231;GO:0044464;GO:0005575;GO:0044444;GO:0031090;GO:0044422; intracellular organelle;Golgi membrane;cytoplasm;cell;membrane-bounded organelle;integral component of membrane;membrane;organelle;Golgi apparatus part;intrinsic component of membrane;Golgi apparatus;intracellular;bounding membrane of organelle;intracellular organelle part;intracellular part;endomembrane system;membrane part;intracellular membrane-bounded organelle;cell part;cellular_component;cytoplasmic part;organelle membrane;organelle part; 3;5;4;2;3;4;2;2;4;3;4;3;4;3;3;3;2;4;2;1;4;3;2; GO:0043169;GO:0003674;GO:0043167;GO:0016740;GO:0015020;GO:0046872;GO:0003824;GO:0016757;GO:0015018;GO:0008194;GO:0016758;GO:0005488; cation binding;molecular_function;ion binding;transferase activity;glucuronosyltransferase activity;metal ion binding;catalytic activity;transferase activity, transferring glycosyl groups;galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;UDP-glycosyltransferase activity;transferase activity, transferring hexosyl groups;binding; 4;1;3;3;6;5;2;4;7;5;5;2; K00735 map00514; Other types of O-glycan biosynthesis; IPR005027;IPR029044; Glycosyl transferase, family 43;Nucleotide-diphospho-sugar transferases; extracellular Hs16905510 681.0 O [O] Posttranslational modification, protein turnover, chaperones; Q5T0N5 Formin-binding protein 1-like OS=Homo sapiens OX=9606 GN=FNBP1L PE=1 SV=3 - [FBP1L_HUMAN] 0.918 0.893 1.512 0.901 0.879 0.883 1.027995521 nan 1.025028441 nan 1.693169093 nan 1.004550626 nan GO:0099515;GO:0006900;GO:0099518;GO:0061024;GO:0060491;GO:0030050;GO:0031344;GO:0071840;GO:0031346;GO:0048869;GO:0010256;GO:0051491;GO:0044093;GO:0048518;GO:0030048;GO:0051128;GO:0016192;GO:0007009;GO:0016050;GO:0046847;GO:0043547;GO:0022607;GO:0051656;GO:0000902;GO:0051345;GO:0016043;GO:0051650;GO:0065007;GO:0043085;GO:0065009;GO:0048646;GO:0051130;GO:0042384;GO:0060271;GO:0006810;GO:0050794;GO:0008150;GO:0051234;GO:0051336;GO:0044782;GO:0006897;GO:0046907;GO:0006898;GO:0044802;GO:0051649;GO:0072583;GO:0010927;GO:0009653;GO:0043087;GO:0044699;GO:0070925;GO:0030705;GO:1902578;GO:0032502;GO:0009987;GO:0006928;GO:0048858;GO:0010324;GO:0097320;GO:0030030;GO:0030031;GO:0050789;GO:0044085;GO:0030029;GO:0006914;GO:0044767;GO:0044765;GO:0044763;GO:0051648;GO:0051179;GO:0051640;GO:0051641;GO:0006996;GO:0051489;GO:1902580;GO:0032990;GO:0050790;GO:0048856;GO:0044087;GO:1902589;GO:0032989;GO:1902582;GO:0044089;GO:0048522; actin filament-based transport;membrane budding;vesicle cytoskeletal trafficking;membrane organization;regulation of cell projection assembly;vesicle transport along actin filament;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;cellular developmental process;endomembrane system organization;positive regulation of filopodium assembly;positive regulation of molecular function;positive regulation of biological process;actin filament-based movement;regulation of cellular component organization;vesicle-mediated transport;plasma membrane organization;vesicle organization;filopodium assembly;positive regulation of GTPase activity;cellular component assembly;establishment of organelle localization;cell morphogenesis;positive regulation of hydrolase activity;cellular component organization;establishment of vesicle localization;biological regulation;positive regulation of catalytic activity;regulation of molecular function;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;cilium assembly;cilium morphogenesis;transport;regulation of cellular process;biological_process;establishment of localization;regulation of hydrolase activity;cilium organization;endocytosis;intracellular transport;receptor-mediated endocytosis;single-organism membrane organization;establishment of localization in cell;clathrin-mediated endocytosis;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;regulation of GTPase activity;single-organism process;organelle assembly;cytoskeleton-dependent intracellular transport;single-organism localization;developmental process;cellular process;movement of cell or subcellular component;cell projection morphogenesis;membrane invagination;membrane tubulation;cell projection organization;cell projection assembly;regulation of biological process;cellular component biogenesis;actin filament-based process;autophagy;single-organism developmental process;single-organism transport;single-organism cellular process;vesicle localization;localization;organelle localization;cellular localization;organelle organization;regulation of filopodium assembly;single-organism cellular localization;cell part morphogenesis;regulation of catalytic activity;anatomical structure development;regulation of cellular component biogenesis;single-organism organelle organization;cellular component morphogenesis;single-organism intracellular transport;positive regulation of cellular component biogenesis;positive regulation of cellular process; 7;5;5;4;4;6;5;2;5;4;4;4;4;2;5;4;5;5;5;6;7;4;4;5;6;3;5;2;5;3;3;4;5;6;4;3;1;3;5;5;6;5;7;4;4;8;4;3;6;2;5;6;3;2;2;4;5;5;6;4;5;2;3;4;3;3;4;3;5;2;4;3;4;5;4;5;4;3;3;4;4;5;3;3; GO:0005938;GO:0031984;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0005794;GO:0043230;GO:0043231;GO:0043232;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0097708;GO:0005623;GO:0005737;GO:0031410;GO:0044464;GO:0005622;GO:0005802;GO:0071944;GO:0070062;GO:0099568;GO:0005886;GO:1903561;GO:0005575;GO:0005576;GO:0098791; cell cortex;organelle subcompartment;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;Golgi apparatus;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;intracellular vesicle;cell;cytoplasm;cytoplasmic vesicle;cell part;intracellular;trans-Golgi network;cell periphery;extracellular exosome;cytoplasmic region;plasma membrane;extracellular vesicle;cellular_component;extracellular region;Golgi subcompartment; 4;4;4;5;2;5;4;3;4;4;3;2;2;3;3;3;2;5;4;3;3;4;4;2;4;5;2;3;5;3;4;5;3;3;1;2;5; GO:0098772;GO:0005085;GO:0005086;GO:0003674;GO:0005488;GO:0008289; molecular function regulator;guanyl-nucleotide exchange factor activity;ARF guanyl-nucleotide exchange factor activity;molecular_function;binding;lipid binding; 2;3;4;1;2;3; K20121 IPR030116;IPR027267;IPR031160;IPR001452;IPR035493;IPR001060;IPR035494; Formin-binding protein 1-like;Arfaptin homology (AH) domain/BAR domain;F-BAR domain;SH3 domain;FNBP1L, SH3 domain;FCH domain;FNBP1L, F-BAR domain; nucleus Hs22046132 464.0 Z [Z] Cytoskeleton; Q8N7P1 Inactive phospholipase D5 OS=Homo sapiens OX=9606 GN=PLD5 PE=2 SV=2 - [PLD5_HUMAN] 1.494 0.83 0.829 1.228 0.772 1.25 1.8 nan 1.590673575 nan 0.998795181 nan 1.619170984 nan GO:0016021;GO:0016020;GO:0005575;GO:0044425;GO:0031224; integral component of membrane;membrane;cellular_component;membrane part;intrinsic component of membrane; 4;2;1;2;3; GO:0003824;GO:0003674; catalytic activity;molecular_function; 2;1; K16861 IPR032803;IPR001736; PLD-like domain;Phospholipase D/Transphosphatidylase; plasma membrane Hs7110641 295.0 R [R] General function prediction only; P00739 Haptoglobin-related protein OS=Homo sapiens OX=9606 GN=HPR PE=2 SV=2 - [HPTR_HUMAN] 1.046 0.871 1 1.046 0.943 1.105 1.200918485 0.000533503 1.109225875 0.003415339 1.148105626 0.000255522 1.171792153 0.001247047 GO:0048583;GO:0098779;GO:0016043;GO:0071840;GO:0050688;GO:0044712;GO:0044710;GO:0043207;GO:0009615;GO:0002682;GO:0009607;GO:0051707;GO:0051704;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0033554;GO:0002831;GO:1903008;GO:0065007;GO:0007005;GO:0006810;GO:0051716;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0031347;GO:0051234;GO:0006897;GO:0051607;GO:0050896;GO:0006898;GO:0043900;GO:0002697;GO:0022411;GO:0032101;GO:0044699;GO:0006508;GO:0009987;GO:0098542;GO:0000422;GO:0000423;GO:0043170;GO:0002230;GO:0080134;GO:0016236;GO:0050789;GO:0098780;GO:0071704;GO:0061726;GO:0006914;GO:0050691;GO:0044763;GO:0009056;GO:0051179;GO:0006996;GO:0044238;GO:1902589;GO:0098792;GO:0002252; regulation of response to stimulus;mitophagy in response to mitochondrial depolarization;cellular component organization;cellular component organization or biogenesis;regulation of defense response to virus;single-organism catabolic process;single-organism metabolic process;response to external biotic stimulus;response to virus;regulation of immune system process;response to biotic stimulus;response to other organism;multi-organism process;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;cellular response to stress;regulation of response to biotic stimulus;organelle disassembly;biological regulation;mitochondrion organization;transport;cellular response to stimulus;defense response;response to stress;biological_process;metabolic process;regulation of defense response;establishment of localization;endocytosis;defense response to virus;response to stimulus;receptor-mediated endocytosis;regulation of multi-organism process;regulation of immune effector process;cellular component disassembly;regulation of response to external stimulus;single-organism process;proteolysis;cellular process;defense response to other organism;mitophagy;macromitophagy;macromolecule metabolic process;positive regulation of defense response to virus by host;regulation of response to stress;macroautophagy;regulation of biological process;response to mitochondrial depolarisation;organic substance metabolic process;mitochondrion disassembly;autophagy;regulation of defense response to virus by host;single-organism cellular process;catabolic process;localization;organelle organization;primary metabolic process;single-organism organelle organization;xenophagy;immune effector process; 3;6;3;2;4;4;3;4;4;3;3;3;2;5;3;4;2;4;4;5;2;5;4;3;4;3;1;2;5;3;6;4;2;7;3;4;4;4;2;5;2;4;4;5;4;6;4;4;2;5;3;6;3;5;3;3;2;4;3;4;5;3; GO:0034358;GO:0031982;GO:0034364;GO:0034366;GO:0043230;GO:0044421;GO:0043227;GO:0043226;GO:0072562;GO:1990777;GO:0032994;GO:0070062;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;vesicle;high-density lipoprotein particle;spherical high-density lipoprotein particle;extracellular organelle;extracellular region part;membrane-bounded organelle;organelle;blood microparticle;lipoprotein particle;protein-lipid complex;extracellular exosome;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;4;4;5;3;2;3;2;3;4;3;4;3;3;2;1;2; GO:0004252;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0030492;GO:0005515;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;hemoglobin binding;protein binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;1;2;3;2;4;5;4;3;6;5; K14477 map05143; African trypanosomiasis; IPR000436;IPR009003;IPR001254;IPR008292;IPR001314; Sushi/SCR/CCP domain;Peptidase S1, PA clan;Serine proteases, trypsin domain;Haptoglobin;Peptidase S1A, chymotrypsin family; mitochondria Hs10337589 723.0 E [E] Amino acid transport and metabolism; Q9NSI6 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=BRWD1 PE=1 SV=4 - [BRWD1_HUMAN] 0.929 0.775 1.536 0.905 0.89 1.091 1.198709677 0.000557965 1.016853933 0.593799718 1.981935484 6.26E-08 1.225842697 0.374021125 GO:0080090;GO:0019222;GO:0032989;GO:1901362;GO:0071840;GO:0048869;GO:0060255;GO:0008360;GO:2001141;GO:0046483;GO:0019438;GO:0022604;GO:0022603;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0000902;GO:0044260;GO:0016043;GO:0065007;GO:1901360;GO:0006366;GO:0065008;GO:0018130;GO:0050793;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0006357;GO:0006351;GO:0032774;GO:0051128;GO:0044249;GO:0034641;GO:0034645;GO:0009653;GO:0044699;GO:0006139;GO:0032502;GO:0009987;GO:0006725;GO:1903506;GO:0051252;GO:0043170;GO:0031326;GO:0031323;GO:0090304;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0006996;GO:0044238;GO:0007010;GO:0048856;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;cellular component morphogenesis;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular developmental process;regulation of macromolecule metabolic process;regulation of cell shape;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;transcription from RNA polymerase II promoter;regulation of biological quality;heterocycle biosynthetic process;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;developmental process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of RNA metabolic process;macromolecule metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;cytoskeleton organization;anatomical structure development;cellular metabolic process; 4;3;4;5;2;4;4;4;6;4;5;5;4;3;2;7;4;5;4;3;2;4;7;3;5;3;4;3;1;2;5;5;5;6;7;6;6;4;4;4;5;3;2;4;2;2;4;7;5;4;5;4;5;6;3;5;5;5;5;3;3;5;3;4;4;3;5;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0043228;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;intracellular organelle part;cytoplasm;nucleolus;nucleus;cell part;cell;non-membrane-bounded organelle;organelle;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;2;3;3;3;3;4;5;5;2;2;3;2;1;4; K11798 IPR001487;IPR017986;IPR001680;IPR015943;IPR019775;IPR018359; Bromodomain;WD40-repeat-containing domain;WD40 repeat;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;Bromodomain, conserved site; nucleus Hs16445436 4833.0 R [R] General function prediction only; P05109 Protein S100-A8 OS=Homo sapiens OX=9606 GN=S100A8 PE=1 SV=1 - [S10A8_HUMAN] 1.04 0.97 0.948 1.263 0.903 1.179 1.072164948 0.795676059 1.398671096 0.258770526 0.977319588 0.304086352 1.305647841 0.098503751 GO:0090087;GO:2001235;GO:0051234;GO:0080090;GO:0019222;GO:2001233;GO:0048584;GO:0048468;GO:0006139;GO:0051173;GO:0031349;GO:0055080;GO:0006882;GO:0045893;GO:0060326;GO:0010043;GO:1901576;GO:1901362;GO:0044707;GO:0071840;GO:0032774;GO:0071705;GO:0051716;GO:0050729;GO:0043207;GO:0009966;GO:0048869;GO:0009617;GO:0051493;GO:0050727;GO:0018193;GO:0033043;GO:0042981;GO:0044093;GO:0051049;GO:0048518;GO:0043280;GO:0002526;GO:0051345;GO:0019725;GO:1902680;GO:0030593;GO:0006935;GO:0010467;GO:0060255;GO:0048583;GO:0050832;GO:0006807;GO:0051090;GO:0030162;GO:0010038;GO:2001141;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0065008;GO:0009607;GO:0009605;GO:0035556;GO:0019538;GO:0048870;GO:0015833;GO:0002376;GO:0019438;GO:0048878;GO:0007165;GO:0070887;GO:0021782;GO:0009891;GO:0006810;GO:0023051;GO:0006928;GO:0008152;GO:0098771;GO:0032496;GO:0043170;GO:0097659;GO:0044267;GO:0016049;GO:0046483;GO:0006919;GO:1903506;GO:0016043;GO:0019219;GO:0065007;GO:0031347;GO:0051254;GO:0010468;GO:0065009;GO:0016477;GO:0006914;GO:0018130;GO:0043085;GO:0098602;GO:0072507;GO:0098609;GO:0046916;GO:0050790;GO:0009889;GO:0048708;GO:0042060;GO:0042063;GO:0006952;GO:0012501;GO:0006950;GO:0036211;GO:0008150;GO:0006954;GO:0006955;GO:0034654;GO:0014002;GO:1902533;GO:0050794;GO:0002523;GO:0010604;GO:0051336;GO:0046903;GO:0055069;GO:0044271;GO:0042330;GO:0051604;GO:0050896;GO:0043412;GO:0006355;GO:0016070;GO:0009059;GO:0006351;GO:0009967;GO:0007159;GO:0051046;GO:0097305;GO:0009611;GO:0051171;GO:0055076;GO:0032103;GO:0032101;GO:0030307;GO:0050801;GO:0030154;GO:0018198;GO:0051128;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0010001;GO:0007154;GO:0051047;GO:0010647;GO:0010646;GO:0051235;GO:0044699;GO:0007417;GO:0009893;GO:0042886;GO:1902531;GO:0072503;GO:0002544;GO:0010557;GO:0017014;GO:0051246;GO:0051247;GO:0044765;GO:0032270;GO:0097530;GO:0031326;GO:2001244;GO:0022610;GO:1903034;GO:0031325;GO:1903036;GO:2001242;GO:0032502;GO:0006996;GO:0010950;GO:0032501;GO:0006875;GO:0031323;GO:0009987;GO:0032119;GO:0006873;GO:0043281;GO:0034645;GO:0001558;GO:0030003;GO:0040011;GO:0006508;GO:0016485;GO:0055082;GO:0032879;GO:0051092;GO:0090304;GO:0051091;GO:0032268;GO:0051252;GO:0001816;GO:0051674;GO:0002237;GO:0002791;GO:0048731;GO:1901360;GO:0097529;GO:0080134;GO:0010952;GO:0042742;GO:1903508;GO:0002793;GO:0016337;GO:0045927;GO:0031328;GO:0051238;GO:1990267;GO:0032602;GO:0097190;GO:0030595;GO:2001056;GO:0097193;GO:0042592;GO:0050900;GO:0010942;GO:0008219;GO:0010941;GO:1990266;GO:0007275;GO:0010628;GO:0097202;GO:0040007;GO:2000116;GO:0033993;GO:0040008;GO:0051050;GO:2000112;GO:0031638;GO:0050789;GO:0043065;GO:0071704;GO:0043067;GO:0010556;GO:0071702;GO:0071621;GO:0043068;GO:0045935;GO:0052547;GO:0052548;GO:0006725;GO:0045087;GO:0006915;GO:0018119;GO:0006464;GO:0044767;GO:0045471;GO:0009058;GO:0045862;GO:0044763;GO:0070488;GO:0055065;GO:0007155;GO:0042221;GO:0022008;GO:0051179;GO:1902578;GO:1901700;GO:0044238;GO:0007010;GO:0044260;GO:0007399;GO:0002790;GO:0009620;GO:0048856;GO:0044237;GO:0070486;GO:0098542;GO:0048522; regulation of peptide transport;positive regulation of apoptotic signaling pathway;establishment of localization;regulation of primary metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;positive regulation of response to stimulus;cell development;nucleobase-containing compound metabolic process;positive regulation of nitrogen compound metabolic process;positive regulation of defense response;cation homeostasis;cellular zinc ion homeostasis;positive regulation of transcription, DNA-templated;cell chemotaxis;response to zinc ion;organic substance biosynthetic process;organic cyclic compound biosynthetic process;single-multicellular organism process;cellular component organization or biogenesis;RNA biosynthetic process;nitrogen compound transport;cellular response to stimulus;positive regulation of inflammatory response;response to external biotic stimulus;regulation of signal transduction;cellular developmental process;response to bacterium;regulation of cytoskeleton organization;regulation of inflammatory response;peptidyl-amino acid modification;regulation of organelle organization;regulation of apoptotic process;positive regulation of molecular function;regulation of transport;positive regulation of biological process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;acute inflammatory response;positive regulation of hydrolase activity;cellular homeostasis;positive regulation of RNA biosynthetic process;neutrophil chemotaxis;chemotaxis;gene expression;regulation of macromolecule metabolic process;regulation of response to stimulus;defense response to fungus;nitrogen compound metabolic process;regulation of sequence-specific DNA binding transcription factor activity;regulation of proteolysis;response to metal ion;regulation of RNA biosynthetic process;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;single organism signaling;regulation of biological quality;response to biotic stimulus;response to external stimulus;intracellular signal transduction;protein metabolic process;cell motility;peptide transport;immune system process;aromatic compound biosynthetic process;chemical homeostasis;signal transduction;cellular response to chemical stimulus;glial cell development;positive regulation of biosynthetic process;transport;regulation of signaling;movement of cell or subcellular component;metabolic process;inorganic ion homeostasis;response to lipopolysaccharide;macromolecule metabolic process;nucleic acid-templated transcription;cellular protein metabolic process;cell growth;heterocycle metabolic process;activation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of nucleic acid-templated transcription;cellular component organization;regulation of nucleobase-containing compound metabolic process;biological regulation;regulation of defense response;positive regulation of RNA metabolic process;regulation of gene expression;regulation of molecular function;cell migration;autophagy;heterocycle biosynthetic process;positive regulation of catalytic activity;single organism cell adhesion;divalent inorganic cation homeostasis;cell-cell adhesion;cellular transition metal ion homeostasis;regulation of catalytic activity;regulation of biosynthetic process;astrocyte differentiation;wound healing;gliogenesis;defense response;programmed cell death;response to stress;protein modification process;biological_process;inflammatory response;immune response;nucleobase-containing compound biosynthetic process;astrocyte development;positive regulation of intracellular signal transduction;regulation of cellular process;leukocyte migration involved in inflammatory response;positive regulation of macromolecule metabolic process;regulation of hydrolase activity;secretion;zinc ion homeostasis;cellular nitrogen compound biosynthetic process;taxis;protein maturation;response to stimulus;macromolecule modification;regulation of transcription, DNA-templated;RNA metabolic process;macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of signal transduction;leukocyte cell-cell adhesion;regulation of secretion;response to alcohol;response to wounding;regulation of nitrogen compound metabolic process;transition metal ion homeostasis;positive regulation of response to external stimulus;regulation of response to external stimulus;positive regulation of cell growth;ion homeostasis;cell differentiation;peptidyl-cysteine modification;regulation of cellular component organization;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;glial cell differentiation;cell communication;positive regulation of secretion;positive regulation of cell communication;regulation of cell communication;maintenance of location;single-organism process;central nervous system development;positive regulation of metabolic process;amide transport;regulation of intracellular signal transduction;cellular divalent inorganic cation homeostasis;chronic inflammatory response;positive regulation of macromolecule biosynthetic process;protein nitrosylation;regulation of protein metabolic process;positive regulation of protein metabolic process;single-organism transport;positive regulation of cellular protein metabolic process;granulocyte migration;regulation of cellular biosynthetic process;positive regulation of intrinsic apoptotic signaling pathway;biological adhesion;regulation of response to wounding;positive regulation of cellular metabolic process;positive regulation of response to wounding;regulation of intrinsic apoptotic signaling pathway;developmental process;organelle organization;positive regulation of endopeptidase activity;multicellular organismal process;cellular metal ion homeostasis;regulation of cellular metabolic process;cellular process;sequestering of zinc ion;cellular ion homeostasis;regulation of cysteine-type endopeptidase activity involved in apoptotic process;cellular macromolecule biosynthetic process;regulation of cell growth;cellular cation homeostasis;locomotion;proteolysis;protein processing;cellular chemical homeostasis;regulation of localization;positive regulation of NF-kappaB transcription factor activity;nucleic acid metabolic process;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of cellular protein metabolic process;regulation of RNA metabolic process;cytokine production;localization of cell;response to molecule of bacterial origin;regulation of peptide secretion;system development;organic cyclic compound metabolic process;myeloid leukocyte migration;regulation of response to stress;positive regulation of peptidase activity;defense response to bacterium;positive regulation of nucleic acid-templated transcription;positive regulation of peptide secretion;single organismal cell-cell adhesion;positive regulation of growth;positive regulation of cellular biosynthetic process;sequestering of metal ion;response to transition metal nanoparticle;chemokine production;apoptotic signaling pathway;leukocyte chemotaxis;positive regulation of cysteine-type endopeptidase activity;intrinsic apoptotic signaling pathway;homeostatic process;leukocyte migration;positive regulation of cell death;cell death;regulation of cell death;neutrophil migration;multicellular organism development;positive regulation of gene expression;activation of cysteine-type endopeptidase activity;growth;regulation of cysteine-type endopeptidase activity;response to lipid;regulation of growth;positive regulation of transport;regulation of cellular macromolecule biosynthetic process;zymogen activation;regulation of biological process;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;regulation of macromolecule biosynthetic process;organic substance transport;granulocyte chemotaxis;positive regulation of programmed cell death;positive regulation of nucleobase-containing compound metabolic process;regulation of peptidase activity;regulation of endopeptidase activity;cellular aromatic compound metabolic process;innate immune response;apoptotic process;peptidyl-cysteine S-nitrosylation;cellular protein modification process;single-organism developmental process;response to ethanol;biosynthetic process;positive regulation of proteolysis;single-organism cellular process;neutrophil aggregation;metal ion homeostasis;cell adhesion;response to chemical;neurogenesis;localization;single-organism localization;response to oxygen-containing compound;primary metabolic process;cytoskeleton organization;cellular macromolecule metabolic process;nervous system development;peptide secretion;response to fungus;anatomical structure development;cellular metabolic process;leukocyte aggregation;defense response to other organism;positive regulation of cellular process; 5;5;3;4;3;5;3;4;4;4;4;7;9;6;5;5;4;5;3;2;6;5;3;5;4;4;4;4;6;5;7;5;6;4;4;2;7;6;6;4;6;6;4;5;4;3;5;3;4;6;5;6;4;3;4;2;3;3;3;3;5;4;3;6;2;5;5;4;4;5;4;4;3;4;2;7;5;4;7;5;3;4;7;7;3;5;2;5;5;5;3;4;3;5;5;3;8;4;9;4;4;6;5;7;4;5;3;5;1;5;3;5;6;5;3;4;4;5;5;9;5;3;5;2;5;6;5;5;6;4;5;5;5;4;4;9;4;4;4;6;5;8;4;3;4;4;2;6;4;4;4;4;3;2;5;3;5;5;8;6;5;7;5;5;4;5;5;5;6;2;5;4;4;6;2;4;8;2;8;4;2;5;6;7;5;4;7;2;5;6;5;3;6;5;5;5;5;4;3;5;6;4;4;4;4;7;5;7;5;4;3;5;4;4;5;5;4;9;6;4;3;4;4;4;6;4;5;8;2;8;5;3;3;6;7;2;6;3;5;5;5;5;5;5;6;7;4;4;6;8;6;3;6;3;6;3;7;8;3;3;6;2;3;4;3;5;4;5;6;4;3;3;6;4;3; GO:0044444;GO:0031982;GO:0005737;GO:0043230;GO:0043232;GO:0005829;GO:0043231;GO:0044424;GO:0044421;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0005886;GO:0016020;GO:0005615;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0071944;GO:1903561;GO:0070062;GO:0005575;GO:0005576; cytoplasmic part;vesicle;cytoplasm;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular membrane-bounded organelle;intracellular part;extracellular region part;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;plasma membrane;membrane;extracellular space;nucleus;cell part;intracellular organelle;cell;intracellular;cell periphery;extracellular vesicle;extracellular exosome;cellular_component;extracellular region; 4;4;4;3;4;5;4;3;2;3;3;2;5;3;2;3;5;2;3;2;3;3;3;4;1;2; GO:0008270;GO:0046872;GO:0035662;GO:0044877;GO:0036041;GO:0050786;GO:0003674;GO:0005488;GO:0046914;GO:0043168;GO:0008017;GO:0036094;GO:0008092;GO:0005504;GO:0031406;GO:1901567;GO:0043169;GO:0043167;GO:0005509;GO:0032403;GO:0008289;GO:0035325;GO:0050544;GO:0043177;GO:0005515;GO:0005102;GO:0050542;GO:0015631;GO:0033293;GO:0050543; zinc ion binding;metal ion binding;Toll-like receptor 4 binding;macromolecular complex binding;long-chain fatty acid binding;RAGE receptor binding;molecular_function;binding;transition metal ion binding;anion binding;microtubule binding;small molecule binding;cytoskeletal protein binding;fatty acid binding;carboxylic acid binding;fatty acid derivative binding;cation binding;ion binding;calcium ion binding;protein complex binding;lipid binding;Toll-like receptor binding;arachidonic acid binding;organic acid binding;protein binding;receptor binding;icosanoid binding;tubulin binding;monocarboxylic acid binding;icosatetraenoic acid binding; 7;5;6;3;5;5;1;2;6;4;5;3;4;4;5;3;4;3;6;4;3;5;5;4;3;4;4;5;6;6; K21127 IPR018247;IPR013787;IPR011992;IPR001751;IPR002048;IPR028474; EF-Hand 1, calcium-binding site;S100/CaBP-9k-type, calcium binding, subdomain;EF-hand domain pair;S100/Calbindin-D9k, conserved site;EF-hand domain;Protein S100-A8; mitochondria P15169 Carboxypeptidase N catalytic chain OS=Homo sapiens OX=9606 GN=CPN1 PE=1 SV=1 - [CBPN_HUMAN] 1.028 1.035 0.939 0.936 1.052 1.124 0.993236715 0.880207931 0.88973384 0.432951888 0.907246377 0.623057291 1.068441065 0.130093782 GO:0051384;GO:0044248;GO:0034641;GO:0006807;GO:0043171;GO:0014070;GO:0009719;GO:1901575;GO:0051604;GO:0033993;GO:0071704;GO:0010467;GO:0031960;GO:0009987;GO:0010815;GO:0008150;GO:0008152;GO:0006508;GO:0016485;GO:0042221;GO:0009056;GO:0010033;GO:0044238;GO:1901564;GO:1901565;GO:0043603;GO:0019538;GO:0009725;GO:0050896;GO:0044237;GO:0043170;GO:0006518;GO:0048545; response to glucocorticoid;cellular catabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;peptide catabolic process;response to organic cyclic compound;response to endogenous stimulus;organic substance catabolic process;protein maturation;response to lipid;organic substance metabolic process;gene expression;response to corticosteroid;cellular process;bradykinin catabolic process;biological_process;metabolic process;proteolysis;protein processing;response to chemical;catabolic process;response to organic substance;primary metabolic process;organonitrogen compound metabolic process;organonitrogen compound catabolic process;cellular amide metabolic process;protein metabolic process;response to hormone;response to stimulus;cellular metabolic process;macromolecule metabolic process;peptide metabolic process;response to steroid hormone; 7;4;4;3;5;5;3;4;5;5;3;5;6;2;6;1;2;5;6;3;3;4;3;4;5;5;4;4;2;3;4;5;5; GO:0005615;GO:0005575;GO:0005576;GO:0044421; extracellular space;cellular_component;extracellular region;extracellular region part; 3;1;2;2; GO:0008238;GO:0003674;GO:0008233;GO:0008235;GO:0008236;GO:0043169;GO:0046914;GO:0004181;GO:0004180;GO:0008270;GO:0004185;GO:0043167;GO:0070011;GO:0008237;GO:0070008;GO:0046872;GO:0016787;GO:0017171;GO:0003824;GO:0005488; exopeptidase activity;molecular_function;peptidase activity;metalloexopeptidase activity;serine-type peptidase activity;cation binding;transition metal ion binding;metallocarboxypeptidase activity;carboxypeptidase activity;zinc ion binding;serine-type carboxypeptidase activity;ion binding;peptidase activity, acting on L-amino acid peptides;metallopeptidase activity;serine-type exopeptidase activity;metal ion binding;hydrolase activity;serine hydrolase activity;catalytic activity;binding; 6;1;4;7;5;4;6;8;7;7;7;3;5;6;6;5;3;4;2;2; K01292 IPR008969;IPR000834;IPR027063; Carboxypeptidase-like, regulatory domain;Peptidase M14, carboxypeptidase A;Carboxypeptidase N catalytic chain; endoplasmic reticulum Hs4503011 956.0 R [R] General function prediction only; Q6PID8 Kelch domain-containing protein 10 OS=Homo sapiens OX=9606 GN=KLHDC10 PE=1 SV=1 - [KLD10_HUMAN] 1.272 1.483 0.475 0.828 1.279 0.749 0.857720836 nan 0.647380766 nan 0.320296696 nan 0.585613761 nan GO:0005737;GO:0043231;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0044424;GO:0043227;GO:0043226; cytoplasm;intracellular membrane-bounded organelle;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle;intracellular part;membrane-bounded organelle;organelle; 4;4;5;2;2;3;1;3;3;3;2; IPR015915;IPR015916;IPR006652; Kelch-type beta propeller;Galactose oxidase, beta-propeller;Kelch repeat type 1; cytosol, nucleus Hs14744278 619.0 R [R] General function prediction only; Q96T23 Remodeling and spacing factor 1 OS=Homo sapiens OX=9606 GN=RSF1 PE=1 SV=2 - [RSF1_HUMAN] 1.511 1.177 0.639 0.904 1.082 0.657 1.283772302 nan 0.835489834 nan 0.542905692 nan 0.607208872 nan GO:0080090;GO:0019222;GO:0051098;GO:0031055;GO:1901362;GO:0071840;GO:0010605;GO:0010604;GO:0043044;GO:0044419;GO:0019058;GO:0044092;GO:0048518;GO:0048519;GO:0060255;GO:2001141;GO:0044403;GO:0046483;GO:0010629;GO:0019438;GO:0051253;GO:0016568;GO:0071103;GO:0022607;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0019080;GO:0019083;GO:0051101;GO:0051100;GO:0051254;GO:0010628;GO:0043170;GO:0097659;GO:1901576;GO:0044033;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0065004;GO:0065009;GO:0018130;GO:0050792;GO:0009889;GO:0050794;GO:0043902;GO:0043903;GO:0043900;GO:0008150;GO:0043392;GO:0008152;GO:0034654;GO:1903900;GO:0016070;GO:1902679;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006352;GO:0010558;GO:0034728;GO:0034080;GO:0032774;GO:0070271;GO:0034724;GO:0044249;GO:0034641;GO:0031497;GO:0050434;GO:0006139;GO:1903902;GO:0043486;GO:0031327;GO:0046782;GO:1903508;GO:0016584;GO:0034508;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0034645;GO:0045892;GO:0045893;GO:0044764;GO:0006338;GO:0006336;GO:0006334;GO:0051252;GO:0006333;GO:1902680;GO:0006807;GO:0061641;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0034622;GO:0071824;GO:0071822;GO:0006325;GO:2000112;GO:2000113;GO:0006323;GO:0050789;GO:0071704;GO:0010467;GO:0051704;GO:0010468;GO:0006351;GO:0045935;GO:0045934;GO:0019219;GO:0006461;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0051173;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0044085;GO:0016032;GO:0048524;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;regulation of binding;chromatin remodeling at centromere;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;ATP-dependent chromatin remodeling;interspecies interaction between organisms;viral life cycle;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;symbiosis, encompassing mutualism through parasitism;heterocycle metabolic process;negative regulation of gene expression;aromatic compound biosynthetic process;negative regulation of RNA metabolic process;chromatin modification;DNA conformation change;cellular component assembly;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;viral gene expression;viral transcription;regulation of DNA binding;negative regulation of binding;positive regulation of RNA metabolic process;positive regulation of gene expression;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;multi-organism metabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;protein-DNA complex assembly;regulation of molecular function;heterocycle biosynthetic process;regulation of viral process;regulation of biosynthetic process;regulation of cellular process;positive regulation of multi-organism process;regulation of symbiosis, encompassing mutualism through parasitism;regulation of multi-organism process;biological_process;negative regulation of DNA binding;metabolic process;nucleobase-containing compound biosynthetic process;regulation of viral life cycle;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;DNA-templated transcription, initiation;negative regulation of macromolecule biosynthetic process;nucleosome organization;CENP-A containing nucleosome assembly;RNA biosynthetic process;protein complex biogenesis;DNA replication-independent nucleosome organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;chromatin assembly;positive regulation of viral transcription;nucleobase-containing compound metabolic process;positive regulation of viral life cycle;histone exchange;negative regulation of cellular biosynthetic process;regulation of viral transcription;positive regulation of nucleic acid-templated transcription;nucleosome positioning;centromere complex assembly;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular macromolecule biosynthetic process;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;multi-organism cellular process;chromatin remodeling;DNA replication-independent nucleosome assembly;nucleosome assembly;regulation of RNA metabolic process;chromatin assembly or disassembly;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;CENP-A containing chromatin organization;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;protein-DNA complex subunit organization;protein complex subunit organization;chromatin organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;DNA packaging;regulation of biological process;organic substance metabolic process;gene expression;multi-organism process;regulation of gene expression;transcription, DNA-templated;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;protein complex assembly;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;cellular component biogenesis;viral process;positive regulation of viral process;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;8;5;2;4;4;8;3;5;4;2;2;4;6;4;4;5;5;5;6;6;4;3;3;4;4;4;5;5;5;5;5;4;7;4;3;4;3;5;2;4;6;3;5;4;4;3;3;4;3;1;6;2;5;5;5;6;5;6;5;5;7;5;6;7;6;4;7;4;4;6;6;4;5;7;5;6;7;7;6;2;4;7;7;5;6;6;3;7;7;6;5;6;6;3;6;5;4;5;4;4;4;5;6;5;5;5;6;6;7;2;3;5;2;5;6;5;5;5;5;3;5;4;4;4;4;3;5;3;3;4;4;3;3; GO:0031974;GO:0005654;GO:0031981;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0043229;GO:0043227;GO:0043226;GO:0044446;GO:0044422;GO:0031010;GO:0070603;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0031213;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nucleoplasm;nuclear lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;intracellular organelle;membrane-bounded organelle;organelle;intracellular organelle part;organelle part;ISWI-type complex;SWI/SNF superfamily-type complex;nucleus;cell part;cell;intracellular;RSF complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;5;3;4;3;4;3;3;3;2;3;2;5;4;5;2;2;3;6;2;1;4; GO:0046914;GO:0046872;GO:0008270;GO:0003674;GO:0005488;GO:0043169;GO:0042393;GO:0043167;GO:0005515; transition metal ion binding;metal ion binding;zinc ion binding;molecular_function;binding;cation binding;histone binding;ion binding;protein binding; 6;5;7;1;2;4;4;3;3; K11657 IPR019787;IPR019786;IPR011011;IPR013083;IPR028942;IPR028938;IPR001965; Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;WHIM1 domain;Remodeling and spacing factor 1;Zinc finger, PHD-type; nucleus Q9GZV1 Ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKRD2 PE=1 SV=3 - [ANKR2_HUMAN] 1.016 1.072 1.186 0.989 1.019 1.025 0.947761194 0.551670802 0.970559372 0.657230516 1.106343284 0.390850951 1.005888126 nan GO:0080090;GO:0019222;GO:2001233;GO:2000291;GO:0048583;GO:0003012;GO:0007165;GO:1901362;GO:0044707;GO:1901360;GO:0051716;GO:0010605;GO:0009966;GO:0048869;GO:0007519;GO:0043067;GO:0042981;GO:0048513;GO:0045661;GO:0045662;GO:0048519;GO:0003008;GO:0042127;GO:0006936;GO:0060255;GO:2001141;GO:0046483;GO:0044700;GO:0007154;GO:0033554;GO:0019438;GO:0042692;GO:1902253;GO:0009892;GO:0070887;GO:0009890;GO:0035556;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0010646;GO:0065007;GO:0006366;GO:0035914;GO:0018130;GO:0050793;GO:0009889;GO:0007517;GO:0050794;GO:0012501;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:1902531;GO:0044767;GO:0044271;GO:0050896;GO:0006355;GO:0006357;GO:0006351;GO:0010558;GO:0032774;GO:0030154;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0061061;GO:0051450;GO:0044699;GO:0006139;GO:0000122;GO:0043618;GO:0043619;GO:2001242;GO:0032502;GO:0016070;GO:0032501;GO:0008283;GO:0014902;GO:0097190;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045596;GO:0045595;GO:0045892;GO:0051154;GO:1901796;GO:0006979;GO:0051239;GO:0051093;GO:0051253;GO:0051252;GO:0010629;GO:0001816;GO:0001817;GO:0006807;GO:0048731;GO:0010830;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0097193;GO:0090304;GO:0014706;GO:0051147;GO:0051146;GO:0045445;GO:0051148;GO:0008219;GO:0010941;GO:0007275;GO:0009888;GO:0072331;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0072332;GO:0010468;GO:0045934;GO:0019219;GO:0006915;GO:1902679;GO:0060538;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0042221;GO:0034599;GO:0043620;GO:0044238;GO:0051153;GO:0048856;GO:0044237;GO:0060537;GO:0010832;GO:0044249;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;regulation of myoblast proliferation;regulation of response to stimulus;muscle system process;signal transduction;organic cyclic compound biosynthetic process;single-multicellular organism process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;regulation of signal transduction;cellular developmental process;skeletal muscle tissue development;regulation of programmed cell death;regulation of apoptotic process;animal organ development;regulation of myoblast differentiation;negative regulation of myoblast differentiation;negative regulation of biological process;system process;regulation of cell proliferation;muscle contraction;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;cell communication;cellular response to stress;aromatic compound biosynthetic process;muscle cell differentiation;regulation of intrinsic apoptotic signaling pathway by p53 class mediator;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of biosynthetic process;intracellular signal transduction;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cell communication;biological regulation;transcription from RNA polymerase II promoter;skeletal muscle cell differentiation;heterocycle biosynthetic process;regulation of developmental process;regulation of biosynthetic process;muscle organ development;regulation of cellular process;programmed cell death;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;regulation of intracellular signal transduction;single-organism developmental process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cell differentiation;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;muscle structure development;myoblast proliferation;single-organism process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;regulation of transcription from RNA polymerase II promoter in response to stress;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;regulation of intrinsic apoptotic signaling pathway;developmental process;RNA metabolic process;multicellular organismal process;cell proliferation;myotube differentiation;apoptotic signaling pathway;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;negative regulation of striated muscle cell differentiation;regulation of signal transduction by p53 class mediator;response to oxidative stress;regulation of multicellular organismal process;negative regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;cytokine production;regulation of cytokine production;nitrogen compound metabolic process;system development;regulation of myotube differentiation;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;intrinsic apoptotic signaling pathway;nucleic acid metabolic process;striated muscle tissue development;regulation of muscle cell differentiation;striated muscle cell differentiation;myoblast differentiation;negative regulation of muscle cell differentiation;cell death;regulation of cell death;multicellular organism development;tissue development;signal transduction by p53 class mediator;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;intrinsic apoptotic signaling pathway by p53 class mediator;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;negative regulation of RNA biosynthetic process;skeletal muscle organ development;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;response to chemical;cellular response to oxidative stress;regulation of DNA-templated transcription in response to stress;primary metabolic process;regulation of striated muscle cell differentiation;anatomical structure development;cellular metabolic process;muscle tissue development;negative regulation of myotube differentiation;cellular biosynthetic process;negative regulation of cellular process; 4;3;5;5;3;4;4;5;3;4;3;4;4;4;7;5;6;4;6;6;2;3;4;5;4;6;4;3;4;4;5;5;7;3;4;4;5;4;7;4;4;4;2;7;6;5;3;4;5;3;5;3;1;2;5;5;3;5;2;6;7;6;5;6;5;4;2;5;3;4;4;2;4;7;6;6;6;2;5;2;3;7;5;2;4;7;7;4;4;6;6;6;4;3;3;5;5;5;4;4;3;4;7;5;5;4;4;6;5;6;5;6;6;5;4;4;4;4;6;6;6;2;3;5;5;7;5;5;5;6;6;6;3;5;3;4;4;3;5;5;3;6;3;3;5;7;4;3; GO:0031974;GO:0031981;GO:0000791;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0016605;GO:0016604;GO:0031674;GO:0005654;GO:0044427;GO:0044446;GO:0044444;GO:0044449;GO:0030016;GO:0030017;GO:0005737;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0005622;GO:0005694;GO:0000785;GO:0032991;GO:0005575;GO:0070013;GO:0043292; membrane-enclosed lumen;nuclear lumen;euchromatin;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;PML body;nuclear body;I band;nucleoplasm;chromosomal part;intracellular organelle part;cytoplasmic part;contractile fiber part;myofibril;sarcomere;cytoplasm;nucleus;nucleoplasm part;cell part;cell;intracellular;chromosome;chromatin;macromolecular complex;cellular_component;intracellular organelle lumen;contractile fiber; 2;5;4;4;4;3;5;4;3;2;3;3;3;2;7;6;4;5;4;3;4;3;6;4;4;5;5;2;2;3;5;3;2;1;4;5; GO:0061629;GO:0005198;GO:0044877;GO:0019901;GO:0019900;GO:0003674;GO:0005488;GO:0043422;GO:0001085;GO:0008092;GO:0008307;GO:0019899;GO:0008134;GO:0005515;GO:0003682;GO:0031432; RNA polymerase II sequence-specific DNA binding transcription factor binding;structural molecule activity;macromolecular complex binding;protein kinase binding;kinase binding;molecular_function;binding;protein kinase B binding;RNA polymerase II transcription factor binding;cytoskeletal protein binding;structural constituent of muscle;enzyme binding;transcription factor binding;protein binding;chromatin binding;titin binding; 6;2;3;6;5;1;2;7;5;4;3;4;4;3;4;5; K21434 IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; nucleus Hs14744423 676.0 R [R] General function prediction only; Q9Y2Q0 Phospholipid-transporting ATPase IA OS=Homo sapiens OX=9606 GN=ATP8A1 PE=1 SV=1 - [AT8A1_HUMAN] 0.576 0.842 0.554 1.168 2.355 0.477 0.684085511 nan 0.49596603 nan 0.657957245 nan 0.202547771 nan GO:0051049;GO:0007612;GO:0006900;GO:0007610;GO:0007611;GO:0061024;GO:0006820;GO:2001138;GO:0071840;GO:0061091;GO:0048518;GO:0016192;GO:0051050;GO:0071702;GO:0015711;GO:0034204;GO:0097035;GO:2001140;GO:0010876;GO:0003008;GO:0016477;GO:0044707;GO:0048870;GO:0044708;GO:0016050;GO:1903793;GO:0015914;GO:0006928;GO:0051674;GO:0050789;GO:0016043;GO:0061092;GO:0065007;GO:0065008;GO:0051130;GO:0006812;GO:0006811;GO:0006810;GO:0050794;GO:0008150;GO:0051234;GO:0032368;GO:0050890;GO:2000147;GO:0044802;GO:0045332;GO:0006869;GO:0051128;GO:0044699;GO:0032370;GO:0040011;GO:0032501;GO:1902591;GO:0050877;GO:0043270;GO:0040012;GO:0032879;GO:0055085;GO:0033036;GO:0046907;GO:0044070;GO:0043269;GO:1902589;GO:2000145;GO:0048194;GO:0030335;GO:0009987;GO:0048193;GO:0030334;GO:0034220;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0051272;GO:0051270;GO:0040017;GO:0015748;GO:1902582;GO:0098655;GO:0048522; regulation of transport;learning;membrane budding;behavior;learning or memory;membrane organization;anion transport;regulation of phospholipid transport;cellular component organization or biogenesis;regulation of phospholipid translocation;positive regulation of biological process;vesicle-mediated transport;positive regulation of transport;organic substance transport;organic anion transport;lipid translocation;regulation of membrane lipid distribution;positive regulation of phospholipid transport;lipid localization;system process;cell migration;single-multicellular organism process;cell motility;single-organism behavior;vesicle organization;positive regulation of anion transport;phospholipid transport;movement of cell or subcellular component;localization of cell;regulation of biological process;cellular component organization;positive regulation of phospholipid translocation;biological regulation;regulation of biological quality;positive regulation of cellular component organization;cation transport;ion transport;transport;regulation of cellular process;biological_process;establishment of localization;regulation of lipid transport;cognition;positive regulation of cell motility;single-organism membrane organization;phospholipid translocation;lipid transport;regulation of cellular component organization;single-organism process;positive regulation of lipid transport;locomotion;multicellular organismal process;single-organism membrane budding;neurological system process;positive regulation of ion transport;regulation of locomotion;regulation of localization;transmembrane transport;macromolecule localization;intracellular transport;regulation of anion transport;regulation of ion transport;single-organism organelle organization;regulation of cell motility;Golgi vesicle budding;positive regulation of cell migration;cellular process;Golgi vesicle transport;regulation of cell migration;ion transmembrane transport;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;positive regulation of cellular component movement;regulation of cellular component movement;positive regulation of locomotion;organophosphate ester transport;single-organism intracellular transport;cation transmembrane transport;positive regulation of cellular process; 4;5;5;2;4;4;6;6;2;5;2;5;3;5;6;5;4;5;4;3;4;3;3;3;5;5;6;4;3;2;3;5;2;3;4;6;5;4;3;1;3;5;5;4;4;6;5;4;2;4;2;2;5;4;4;3;3;4;3;5;6;5;4;4;6;5;2;6;5;5;4;3;4;2;3;3;4;4;4;3;5;5;6;3; GO:0005783;GO:0031984;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0044431;GO:0097708;GO:0005794;GO:0099503;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044433;GO:0031224;GO:0012505;GO:0012506;GO:0042583;GO:0044444;GO:0005886;GO:0031988;GO:0005737;GO:0030667;GO:0031090;GO:0031410;GO:0030141;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0000139;GO:0071944;GO:0044446;GO:0070062;GO:0098805;GO:0043226;GO:0098791;GO:0042584;GO:1903561;GO:0005802;GO:0005575;GO:0005576; endoplasmic reticulum;organelle subcompartment;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;Golgi apparatus part;intracellular vesicle;Golgi apparatus;secretory vesicle;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;intrinsic component of membrane;endomembrane system;vesicle membrane;chromaffin granule;cytoplasmic part;plasma membrane;membrane-bounded vesicle;cytoplasm;secretory granule membrane;organelle membrane;cytoplasmic vesicle;secretory granule;cytoplasmic vesicle membrane;cell part;cell;intracellular;Golgi membrane;cell periphery;intracellular organelle part;extracellular exosome;whole membrane;organelle;Golgi subcompartment;chromaffin granule membrane;extracellular vesicle;trans-Golgi network;cellular_component;extracellular region; 4;4;4;5;4;2;4;4;4;6;4;3;4;3;2;2;2;3;3;4;3;3;4;5;4;3;5;4;4;3;5;4;5;2;2;3;5;3;3;4;3;2;5;5;3;5;1;2; GO:0004012;GO:1901363;GO:0005548;GO:0000166;GO:0046872;GO:0005319;GO:0016818;GO:0097367;GO:0016817;GO:0019829;GO:0005524;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042625;GO:0042626;GO:0042623;GO:0015399;GO:0032549;GO:0017076;GO:0022804;GO:0016787;GO:0003824;GO:0022891;GO:0022892;GO:0097159;GO:0043492;GO:0015405;GO:0015075;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043169;GO:0016820;GO:0000287;GO:0043167;GO:0008324;GO:0030554;GO:0001882;GO:0001883;GO:0005215;GO:0017111;GO:0036094;GO:0043168;GO:0022857;GO:0022853; phospholipid-translocating ATPase activity;heterocyclic compound binding;phospholipid transporter activity;nucleotide binding;metal ion binding;lipid transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;cation-transporting ATPase activity;ATP binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase coupled ion transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;primary active transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;active transmembrane transporter activity;hydrolase activity;catalytic activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;organic cyclic compound binding;ATPase activity, coupled to movement of substances;P-P-bond-hydrolysis-driven transmembrane transporter activity;ion transmembrane transporter activity;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;cation binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;magnesium ion binding;ion binding;cation transmembrane transporter activity;adenyl nucleotide binding;nucleoside binding;purine nucleoside binding;transporter activity;nucleoside-triphosphatase activity;small molecule binding;anion binding;transmembrane transporter activity;active ion transmembrane transporter activity; 6;3;5;4;5;4;5;3;4;7;6;1;2;8;4;6;6;9;5;5;5;4;3;2;4;3;3;10;6;5;6;6;5;6;4;5;4;5;6;3;6;6;4;5;2;7;3;4;3;5; K14802 IPR008250;IPR023298;IPR023299;IPR023214;IPR018303;IPR032631;IPR032630;IPR006539;IPR001757; P-type ATPase, A domain;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;HAD-like domain;P-type ATPase, phosphorylation site;P-type ATPase, N-terminal;P-type ATPase, C-terminal;P-type ATPase, subfamily IV;P-type ATPase; plasma membrane Hs17978471 2422.0 R [R] General function prediction only; P61513 60S ribosomal protein L37a OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2 - [RL37A_HUMAN] 0.982 1.207 0.953 1.125 0.987 0.934 0.813587407 nan 1.139817629 nan 0.789560895 nan 0.946301925 nan GO:1901564;GO:0044249;GO:0006807;GO:0044237;GO:0034645;GO:0044260;GO:0043043;GO:0043604;GO:0071704;GO:0010467;GO:0044267;GO:1901566;GO:0009987;GO:1901576;GO:0044271;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:0043170;GO:0044238;GO:0019538;GO:0034641;GO:0043603;GO:0006518;GO:0006412; organonitrogen compound metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecule biosynthetic process;cellular macromolecule metabolic process;peptide biosynthetic process;amide biosynthetic process;organic substance metabolic process;gene expression;cellular protein metabolic process;organonitrogen compound biosynthetic process;cellular process;organic substance biosynthetic process;cellular nitrogen compound biosynthetic process;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;macromolecule metabolic process;primary metabolic process;protein metabolic process;cellular nitrogen compound metabolic process;cellular amide metabolic process;peptide metabolic process;translation; 4;4;3;3;5;4;6;6;3;5;5;5;2;4;5;3;5;1;2;4;3;4;4;5;5;6; GO:0043231;GO:0022626;GO:0022625;GO:1990904;GO:0043229;GO:0043228;GO:0015934;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0030054;GO:0030055;GO:0005737;GO:0044446;GO:0070062;GO:0005634;GO:0030529;GO:0044445;GO:0070161;GO:0044391;GO:0005912;GO:0032991;GO:1903561;GO:0031982;GO:0043230;GO:0005840;GO:0043232;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421;GO:0044422; intracellular membrane-bounded organelle;cytosolic ribosome;cytosolic large ribosomal subunit;ribonucleoprotein complex;intracellular organelle;non-membrane-bounded organelle;large ribosomal subunit;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;cell junction;cell-substrate junction;cytoplasm;intracellular organelle part;extracellular exosome;nucleus;intracellular ribonucleoprotein complex;cytosolic part;anchoring junction;ribosomal subunit;adherens junction;macromolecular complex;extracellular vesicle;vesicle;extracellular organelle;ribosome;intracellular non-membrane-bounded organelle;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part;organelle part; 4;6;6;3;3;3;5;4;5;3;2;2;3;4;3;4;5;4;5;3;4;4;2;3;4;3;5;4;5;2;2;3;1;4;2;3;2;2; GO:0003676;GO:1901363;GO:0043169;GO:0003735;GO:0003723;GO:0005198;GO:0044822;GO:0046872;GO:0043167;GO:0097159;GO:0003674;GO:0005488; nucleic acid binding;heterocyclic compound binding;cation binding;structural constituent of ribosome;RNA binding;structural molecule activity;poly(A) RNA binding;metal ion binding;ion binding;organic cyclic compound binding;molecular_function;binding; 4;3;4;3;5;2;6;5;3;3;1;2; K02921 map03010; Ribosome; IPR011332;IPR002674;IPR011331; Zinc-binding ribosomal protein;Ribosomal protein L37ae;Ribosomal protein L37ae/L37e; extracellular Hs4506643 184.0 J [J] Translation, ribosomal structure and biogenesis; Q5SQS7 SH2 domain-containing protein 4B OS=Homo sapiens OX=9606 GN=SH2D4B PE=2 SV=1 - [SH24B_HUMAN] 1.374 1.024 0.72 0.714 1.395 0.794 1.341796875 nan 0.511827957 nan 0.703125 nan 0.569175627 nan IPR000980; SH2 domain; cytosol Hs21361891 324.0 R [R] General function prediction only; Q96M86 Dynein heavy chain domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DNHD1 PE=2 SV=2 - [DNHD1_HUMAN] 1.224 0.996 0.848 1.228 0.997 0.844 1.228915663 0.670882239 1.231695085 0.820905449 0.851405622 0.143887349 0.846539619 0.851724093 GO:0006928;GO:0044699;GO:0009987;GO:0008150;GO:0007017;GO:0007018;GO:0044763; movement of cell or subcellular component;single-organism process;cellular process;biological_process;microtubule-based process;microtubule-based movement;single-organism cellular process; 4;2;2;1;4;5;3; GO:0044464;GO:0043229;GO:0043228;GO:0030286;GO:0043227;GO:0043226;GO:0005856;GO:0005575;GO:0070062;GO:0005875;GO:0044430;GO:0015630;GO:1902494;GO:0043230;GO:1903561;GO:0031982;GO:0043234;GO:0032991;GO:0043232;GO:0005623;GO:0005622;GO:0044446;GO:0005576;GO:0044424;GO:0044421;GO:0044422; cell part;intracellular organelle;non-membrane-bounded organelle;dynein complex;membrane-bounded organelle;organelle;cytoskeleton;cellular_component;extracellular exosome;microtubule associated complex;cytoskeletal part;microtubule cytoskeleton;catalytic complex;extracellular organelle;extracellular vesicle;vesicle;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cell;intracellular;intracellular organelle part;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;3;5;3;2;5;1;4;4;4;6;4;3;3;4;3;2;4;2;3;3;2;3;2;2; GO:0003674;GO:0003774;GO:0003777;GO:0016787;GO:0017111;GO:0003824;GO:0016818;GO:0016817;GO:0016462; molecular_function;motor activity;microtubule motor activity;hydrolase activity;nucleoside-triphosphatase activity;catalytic activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity; 1;8;9;3;7;2;5;4;6; IPR004273;IPR035699;IPR013602;IPR024743;IPR026983;IPR027417; Dynein heavy chain domain;Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;Dynein heavy chain, domain-2;Dynein heavy chain, coiled coil stalk;Dynein heavy chain;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Hs21389555 2050.0 Z [Z] Cytoskeleton; O75366 Advillin OS=Homo sapiens OX=9606 GN=AVIL PE=1 SV=3 - [AVIL_HUMAN] 1.085 0.839 1.005 1.022 0.929 2.056 1.293206198 nan 1.100107643 nan 1.197854589 nan 2.2131324 nan GO:0048468;GO:0008064;GO:0032989;GO:0031344;GO:0071840;GO:0031346;GO:0065003;GO:0030042;GO:0048869;GO:0051494;GO:0051493;GO:0045664;GO:0045666;GO:0010720;GO:0048518;GO:0048519;GO:1901880;GO:0010976;GO:0010975;GO:0030041;GO:0044707;GO:0010639;GO:0031333;GO:0032535;GO:0022607;GO:1901879;GO:0031175;GO:0030029;GO:0050789;GO:0000902;GO:0016043;GO:0090066;GO:0065007;GO:0065008;GO:0051130;GO:0060271;GO:0050793;GO:0050794;GO:0008154;GO:0008150;GO:0051239;GO:0032956;GO:0043254;GO:0051962;GO:0051960;GO:0022411;GO:0033043;GO:0030154;GO:0051129;GO:0051128;GO:0043244;GO:0009653;GO:0043241;GO:0044699;GO:0043242;GO:0050767;GO:0051240;GO:0060284;GO:0050769;GO:0043933;GO:0032271;GO:0051693;GO:0032502;GO:0032501;GO:0032272;GO:0009987;GO:0045597;GO:0045595;GO:0032990;GO:0051258;GO:0051094;GO:0048731;GO:0030030;GO:0030036;GO:0034622;GO:0007275;GO:0030832;GO:0030833;GO:0030834;GO:0030835;GO:0071822;GO:0030837;GO:0051261;GO:0070271;GO:0048666;GO:0032970;GO:0030182;GO:0006461;GO:0032984;GO:0044767;GO:0044763;GO:0022008;GO:0043624;GO:0043623;GO:0006996;GO:0007015;GO:0048699;GO:0007010;GO:0048858;GO:0007399;GO:0048856;GO:0044087;GO:1902589;GO:0044085;GO:2000026;GO:0048523;GO:0048522; cell development;regulation of actin polymerization or depolymerization;cellular component morphogenesis;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;macromolecular complex assembly;actin filament depolymerization;cellular developmental process;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;negative regulation of protein depolymerization;positive regulation of neuron projection development;regulation of neuron projection development;actin filament polymerization;single-multicellular organism process;negative regulation of organelle organization;negative regulation of protein complex assembly;regulation of cellular component size;cellular component assembly;regulation of protein depolymerization;neuron projection development;actin filament-based process;regulation of biological process;cell morphogenesis;cellular component organization;regulation of anatomical structure size;biological regulation;regulation of biological quality;positive regulation of cellular component organization;cilium morphogenesis;regulation of developmental process;regulation of cellular process;actin polymerization or depolymerization;biological_process;regulation of multicellular organismal process;regulation of actin cytoskeleton organization;regulation of protein complex assembly;positive regulation of nervous system development;regulation of nervous system development;cellular component disassembly;regulation of organelle organization;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein complex disassembly;anatomical structure morphogenesis;protein complex disassembly;single-organism process;negative regulation of protein complex disassembly;regulation of neurogenesis;positive regulation of multicellular organismal process;regulation of cell development;positive regulation of neurogenesis;macromolecular complex subunit organization;regulation of protein polymerization;actin filament capping;developmental process;multicellular organismal process;negative regulation of protein polymerization;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;cell part morphogenesis;protein polymerization;positive regulation of developmental process;system development;cell projection organization;actin cytoskeleton organization;cellular macromolecular complex assembly;multicellular organism development;regulation of actin filament length;regulation of actin filament polymerization;regulation of actin filament depolymerization;negative regulation of actin filament depolymerization;protein complex subunit organization;negative regulation of actin filament polymerization;protein depolymerization;protein complex biogenesis;neuron development;regulation of actin filament-based process;neuron differentiation;protein complex assembly;macromolecular complex disassembly;single-organism developmental process;single-organism cellular process;neurogenesis;cellular protein complex disassembly;cellular protein complex assembly;organelle organization;actin filament organization;generation of neurons;cytoskeleton organization;cell projection morphogenesis;nervous system development;anatomical structure development;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process; 4;6;4;5;2;5;5;8;4;6;6;7;6;5;2;2;6;6;6;8;3;5;5;4;4;6;5;4;2;5;3;4;2;3;4;6;3;3;7;1;3;5;4;4;5;4;5;5;4;4;5;3;6;2;5;6;3;5;5;4;5;8;2;2;6;2;4;4;5;7;3;4;4;5;6;4;5;6;7;7;5;7;8;4;5;4;6;5;5;3;3;6;7;6;4;6;7;5;5;5;3;3;4;3;4;3;3; GO:0030424;GO:0042995;GO:0043232;GO:0044424;GO:0043229;GO:0043228;GO:0005856;GO:0005737;GO:0043005;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0043226;GO:0097458;GO:0005575; axon;cell projection;intracellular non-membrane-bounded organelle;intracellular part;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;cytoplasm;neuron projection;cell part;cell;intracellular;actin cytoskeleton;organelle;neuron part;cellular_component; 5;3;4;3;3;3;5;4;4;2;2;3;6;2;3;1; GO:0003674;GO:0005488;GO:0003779;GO:0008092;GO:0005515; molecular_function;binding;actin binding;cytoskeletal protein binding;protein binding; 1;2;5;4;3; K08017 IPR029006;IPR007122;IPR007123;IPR003128;IPR030014; ADF-H/Gelsolin-like domain;Villin/Gelsolin;Gelsolin-like domain;Villin headpiece;Advillin; cytosol Hs17572824 1704.0 Z [Z] Cytoskeleton; Q9UNQ0 ATP-binding cassette sub-family G member 2 OS=Homo sapiens OX=9606 GN=ABCG2 PE=1 SV=3 - [ABCG2_HUMAN] 0.451 0.466 2.751 0.607 0.531 0.893 0.967811159 nan 1.143126177 nan 5.903433476 nan 1.68173258 nan GO:0055072;GO:0044281;GO:0055076;GO:0098771;GO:1901360;GO:0043200;GO:0044710;GO:0071704;GO:0046483;GO:0019725;GO:0031960;GO:0051593;GO:0010038;GO:0010039;GO:0010035;GO:0010033;GO:0051704;GO:1901678;GO:0044703;GO:0044702;GO:1901564;GO:0044707;GO:0044706;GO:0010243;GO:0048878;GO:0009725;GO:0031667;GO:0006807;GO:0046916;GO:0009719;GO:0065007;GO:0065008;GO:0042908;GO:0006810;GO:0051716;GO:0008150;GO:0008152;GO:0051234;GO:0000003;GO:0050896;GO:0097305;GO:0097306;GO:0050801;GO:0055065;GO:0009790;GO:0034641;GO:0009792;GO:0070887;GO:0044699;GO:1901698;GO:0071407;GO:0033273;GO:0071383;GO:0032502;GO:0032501;GO:0006879;GO:0048609;GO:0032504;GO:0006875;GO:0009987;GO:0071396;GO:0006873;GO:0032870;GO:0001101;GO:0030003;GO:0055080;GO:0055082;GO:0055085;GO:0006082;GO:0007565;GO:0015886;GO:0042493;GO:0014070;GO:0048545;GO:0071495;GO:0009991;GO:0051384;GO:1990267;GO:0071385;GO:0071384;GO:0042592;GO:0072521;GO:0060136;GO:0007275;GO:0015893;GO:0033993;GO:1901654;GO:0046618;GO:0071705;GO:0071310;GO:0071702;GO:0009605;GO:0006855;GO:0006725;GO:0007584;GO:0044767;GO:0022414;GO:0044765;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:1901700;GO:1901701;GO:0071549;GO:0071548;GO:0048856;GO:0044237;GO:1901655;GO:0046415;GO:0051181; iron ion homeostasis;small molecule metabolic process;transition metal ion homeostasis;inorganic ion homeostasis;organic cyclic compound metabolic process;response to amino acid;single-organism metabolic process;organic substance metabolic process;heterocycle metabolic process;cellular homeostasis;response to corticosteroid;response to folic acid;response to metal ion;response to iron ion;response to inorganic substance;response to organic substance;multi-organism process;iron coordination entity transport;multi-organism reproductive process;single organism reproductive process;organonitrogen compound metabolic process;single-multicellular organism process;multi-multicellular organism process;response to organonitrogen compound;chemical homeostasis;response to hormone;response to nutrient levels;nitrogen compound metabolic process;cellular transition metal ion homeostasis;response to endogenous stimulus;biological regulation;regulation of biological quality;xenobiotic transport;transport;cellular response to stimulus;biological_process;metabolic process;establishment of localization;reproduction;response to stimulus;response to alcohol;cellular response to alcohol;ion homeostasis;metal ion homeostasis;embryo development;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;cellular response to chemical stimulus;single-organism process;response to nitrogen compound;cellular response to organic cyclic compound;response to vitamin;cellular response to steroid hormone stimulus;developmental process;multicellular organismal process;cellular iron ion homeostasis;multicellular organismal reproductive process;multicellular organism reproduction;cellular metal ion homeostasis;cellular process;cellular response to lipid;cellular ion homeostasis;cellular response to hormone stimulus;response to acid chemical;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;organic acid metabolic process;female pregnancy;heme transport;response to drug;response to organic cyclic compound;response to steroid hormone;cellular response to endogenous stimulus;response to extracellular stimulus;response to glucocorticoid;response to transition metal nanoparticle;cellular response to glucocorticoid stimulus;cellular response to corticosteroid stimulus;homeostatic process;purine-containing compound metabolic process;embryonic process involved in female pregnancy;multicellular organism development;drug transport;response to lipid;response to ketone;drug export;nitrogen compound transport;cellular response to organic substance;organic substance transport;response to external stimulus;drug transmembrane transport;cellular aromatic compound metabolic process;response to nutrient;single-organism developmental process;reproductive process;single-organism transport;single-organism cellular process;response to chemical;localization;single-organism localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular response to dexamethasone stimulus;response to dexamethasone;anatomical structure development;cellular metabolic process;cellular response to ketone;urate metabolic process;cofactor transport; 10;4;9;7;4;5;3;3;4;4;6;6;5;5;4;4;2;5;3;3;4;3;3;4;5;4;5;3;9;3;2;3;5;4;3;1;2;3;2;2;5;6;6;8;5;4;6;4;2;4;6;5;6;2;2;10;3;3;8;2;6;6;5;4;7;7;5;4;4;4;6;4;5;5;4;4;7;4;8;7;4;5;4;4;5;5;5;6;5;5;5;3;5;4;4;3;2;4;3;3;2;3;4;5;7;6;3;3;6;5;5; GO:0031975;GO:0016021;GO:0016020;GO:0098589;GO:0031967;GO:0031966;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0044464;GO:0043229;GO:0043227;GO:0043226;GO:0031224;GO:0044429;GO:0044446;GO:0044444;GO:0045177;GO:0031090;GO:0005634;GO:0005739;GO:0044459;GO:0005623;GO:0005622;GO:0005740;GO:0071944;GO:0098805;GO:0016324;GO:0005886;GO:0005737;GO:0005575; envelope;integral component of membrane;membrane;membrane region;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;plasma membrane region;cell part;intracellular organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;mitochondrial part;intracellular organelle part;cytoplasmic part;apical part of cell;organelle membrane;nucleus;mitochondrion;plasma membrane part;cell;intracellular;mitochondrial envelope;cell periphery;whole membrane;apical plasma membrane;plasma membrane;cytoplasm;cellular_component; 3;4;2;3;4;4;4;3;2;2;4;2;3;3;2;3;4;3;4;3;3;5;5;3;2;3;5;3;3;4;3;4;1; GO:1901363;GO:0015232;GO:0000166;GO:0016818;GO:0097367;GO:0016817;GO:0022804;GO:0042910;GO:0015405;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0051184;GO:0042626;GO:0042623;GO:0015399;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0036094;GO:0008559;GO:0097159;GO:0016462;GO:0032559;GO:0090484;GO:0032555;GO:0046983;GO:0032550;GO:0032553;GO:0035639;GO:0015238;GO:0043168;GO:0016820;GO:0043167;GO:0042802;GO:0042803;GO:0005215;GO:0030554;GO:0005515;GO:0043492;GO:0001883;GO:0001882;GO:0017111;GO:0022857; heterocyclic compound binding;heme transporter activity;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;active transmembrane transporter activity;xenobiotic transporter activity;P-P-bond-hydrolysis-driven transmembrane transporter activity;molecular_function;binding;ATPase activity;nucleoside phosphate binding;cofactor transporter activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;primary active transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;small molecule binding;xenobiotic-transporting ATPase activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;drug transporter activity;purine ribonucleotide binding;protein dimerization activity;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;drug transmembrane transporter activity;anion binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ion binding;identical protein binding;protein homodimerization activity;transporter activity;adenyl nucleotide binding;protein binding;ATPase activity, coupled to movement of substances;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;transmembrane transporter activity; 3;4;4;5;3;4;4;3;6;1;2;8;4;3;6;9;5;5;5;6;3;2;3;4;3;6;6;3;5;4;6;4;5;4;4;5;3;4;5;2;6;3;10;5;4;7;3; K05681 map02010;map04976; ABC transporters;Bile secretion; IPR013525;IPR003593;IPR027417;IPR030256;IPR003439; ABC-2 type transporter;AAA+ ATPase domain;P-loop containing nucleoside triphosphate hydrolase;ATP-binding cassette subfamily G member 2;ABC transporter-like; plasma membrane Hs4757850 1345.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q8IZT6 Abnormal spindle-like microcephaly-associated protein OS=Homo sapiens OX=9606 GN=ASPM PE=1 SV=2 - [ASPM_HUMAN] 0.986 0.709 0.858 0.858 0.935 3.926 1.390691114 nan 0.917647059 nan 1.210155148 nan 4.198930481 nan GO:0048589;GO:0048584;GO:0048583;GO:0008584;GO:0007292;GO:0030111;GO:0060322;GO:0007165;GO:0007166;GO:0051657;GO:0051651;GO:0071840;GO:0051716;GO:0000003;GO:0009966;GO:0009967;GO:0045137;GO:0045665;GO:0045664;GO:0048513;GO:0010720;GO:0010721;GO:0048518;GO:0048519;GO:0051704;GO:1902692;GO:0042127;GO:2000241;GO:0019827;GO:0048468;GO:0021543;GO:0007281;GO:0003006;GO:0007283;GO:0044700;GO:0044703;GO:0044702;GO:0044707;GO:0048870;GO:0016055;GO:0051782;GO:0060284;GO:2000179;GO:0098727;GO:0060828;GO:0021537;GO:0022607;GO:0090263;GO:0055057;GO:0006928;GO:0000226;GO:0007067;GO:0048103;GO:0008406;GO:0016043;GO:0065003;GO:0065007;GO:0007049;GO:2000648;GO:0016477;GO:0048477;GO:0046546;GO:0050793;GO:0050794;GO:0060070;GO:0008150;GO:0051239;GO:0051235;GO:0046661;GO:0097150;GO:0051445;GO:0007548;GO:0007420;GO:0007051;GO:0050896;GO:0051962;GO:0051961;GO:0051960;GO:0048869;GO:0009786;GO:0051240;GO:0070271;GO:0030154;GO:0019953;GO:0036445;GO:0023056;GO:0023052;GO:0050768;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0007417;GO:0050767;GO:0007126;GO:0051321;GO:0051241;GO:0000280;GO:0050769;GO:0043933;GO:2000177;GO:0051640;GO:0072091;GO:0032502;GO:0040011;GO:0032501;GO:0048608;GO:0048609;GO:0032504;GO:0008283;GO:0000212;GO:0009987;GO:0045597;GO:0045596;GO:0045595;GO:0048232;GO:0021987;GO:0007405;GO:0051093;GO:0051225;GO:0065008;GO:0051094;GO:0051726;GO:0030177;GO:0051674;GO:0051302;GO:0048731;GO:0017145;GO:0008284;GO:0061458;GO:0051653;GO:1903047;GO:1903046;GO:0090306;GO:0022402;GO:0008356;GO:0007275;GO:0051301;GO:0045769;GO:0040007;GO:0071822;GO:0002052;GO:0050789;GO:0001764;GO:0007276;GO:0061351;GO:2000026;GO:0021872;GO:0021873;GO:0000278;GO:0030182;GO:0006461;GO:0044767;GO:0022414;GO:0044763;GO:0022412;GO:0007154;GO:0022008;GO:0070925;GO:0051642;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0048699;GO:0007017;GO:0007010;GO:0007399;GO:0051661;GO:0048856;GO:0072089;GO:1902589;GO:0044085;GO:0030900;GO:0048285;GO:1902580;GO:0048523;GO:0048522; developmental growth;positive regulation of response to stimulus;regulation of response to stimulus;male gonad development;female gamete generation;regulation of Wnt signaling pathway;head development;signal transduction;cell surface receptor signaling pathway;maintenance of organelle location;maintenance of location in cell;cellular component organization or biogenesis;cellular response to stimulus;reproduction;regulation of signal transduction;positive regulation of signal transduction;development of primary sexual characteristics;negative regulation of neuron differentiation;regulation of neuron differentiation;animal organ development;positive regulation of cell development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;multi-organism process;regulation of neuroblast proliferation;regulation of cell proliferation;regulation of reproductive process;stem cell population maintenance;cell development;pallium development;germ cell development;developmental process involved in reproduction;spermatogenesis;single organism signaling;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;cell motility;Wnt signaling pathway;negative regulation of cell division;regulation of cell development;positive regulation of neural precursor cell proliferation;maintenance of cell number;regulation of canonical Wnt signaling pathway;telencephalon development;cellular component assembly;positive regulation of canonical Wnt signaling pathway;neuroblast division;movement of cell or subcellular component;microtubule cytoskeleton organization;mitotic nuclear division;somatic stem cell division;gonad development;cellular component organization;macromolecular complex assembly;biological regulation;cell cycle;positive regulation of stem cell proliferation;cell migration;oogenesis;development of primary male sexual characteristics;regulation of developmental process;regulation of cellular process;canonical Wnt signaling pathway;biological_process;regulation of multicellular organismal process;maintenance of location;male sex differentiation;neuronal stem cell population maintenance;regulation of meiotic cell cycle;sex differentiation;brain development;spindle organization;response to stimulus;positive regulation of nervous system development;negative regulation of nervous system development;regulation of nervous system development;cellular developmental process;regulation of asymmetric cell division;positive regulation of multicellular organismal process;protein complex biogenesis;cell differentiation;sexual reproduction;neuronal stem cell division;positive regulation of signaling;signaling;negative regulation of neurogenesis;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;central nervous system development;regulation of neurogenesis;meiotic nuclear division;meiotic cell cycle;negative regulation of multicellular organismal process;nuclear division;positive regulation of neurogenesis;macromolecular complex subunit organization;regulation of neural precursor cell proliferation;organelle localization;regulation of stem cell proliferation;developmental process;locomotion;multicellular organismal process;reproductive structure development;multicellular organismal reproductive process;multicellular organism reproduction;cell proliferation;meiotic spindle organization;cellular process;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;male gamete generation;cerebral cortex development;neuroblast proliferation;negative regulation of developmental process;spindle assembly;regulation of biological quality;positive regulation of developmental process;regulation of cell cycle;positive regulation of Wnt signaling pathway;localization of cell;regulation of cell division;system development;stem cell division;positive regulation of cell proliferation;reproductive system development;spindle localization;mitotic cell cycle process;meiotic cell cycle process;spindle assembly involved in meiosis;cell cycle process;asymmetric cell division;multicellular organism development;cell division;negative regulation of asymmetric cell division;growth;protein complex subunit organization;positive regulation of neuroblast proliferation;regulation of biological process;neuron migration;gamete generation;neural precursor cell proliferation;regulation of multicellular organismal development;forebrain generation of neurons;forebrain neuroblast division;mitotic cell cycle;neuron differentiation;protein complex assembly;single-organism developmental process;reproductive process;single-organism cellular process;cellular process involved in reproduction in multicellular organism;cell communication;neurogenesis;organelle assembly;centrosome localization;localization;single-organism localization;cellular localization;organelle organization;generation of neurons;microtubule-based process;cytoskeleton organization;nervous system development;maintenance of centrosome location;anatomical structure development;stem cell proliferation;single-organism organelle organization;cellular component biogenesis;forebrain development;organelle fission;single-organism cellular localization;negative regulation of cellular process;positive regulation of cellular process; 3;3;3;5;5;5;4;4;5;5;4;2;3;2;4;4;4;6;7;4;5;5;2;2;2;6;4;3;4;4;4;4;3;6;3;3;3;3;3;6;4;5;5;3;6;4;4;6;6;4;5;5;6;4;3;5;2;4;5;4;5;5;3;3;7;1;3;3;5;5;4;4;4;5;2;4;4;5;4;5;3;4;5;3;7;3;2;5;3;4;4;2;5;6;4;3;3;6;5;4;5;4;5;2;2;2;4;3;3;3;4;2;4;4;4;5;4;5;3;6;3;3;4;5;3;4;4;5;4;5;5;5;4;5;4;5;4;4;5;2;5;6;2;5;4;4;4;5;6;5;6;5;3;2;3;4;4;6;5;5;2;3;3;4;7;4;5;5;5;3;4;4;3;4;5;4;3;3; GO:0099512;GO:0099513;GO:0000922;GO:0043231;GO:0043232;GO:0044424;GO:0030496;GO:0043229;GO:0043228;GO:1990752;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0044422;GO:0036449;GO:0005874;GO:0005737;GO:0005634;GO:0097431;GO:0044464;GO:0005623;GO:0005622;GO:0072687;GO:0005819;GO:0015630;GO:0072686;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;spindle pole;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;midbody;intracellular organelle;non-membrane-bounded organelle;microtubule end;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;organelle part;microtubule minus-end;microtubule;cytoplasm;nucleus;mitotic spindle pole;cell part;cell;intracellular;meiotic spindle;spindle;microtubule cytoskeleton;mitotic spindle;cellular_component; 2;3;5;4;4;3;3;3;3;5;3;2;5;4;3;2;5;4;4;5;6;2;2;3;6;5;6;6;1; K16743 IPR013783;IPR016024;IPR029955;IPR000048;IPR031549;IPR001715;IPR027417; Immunoglobulin-like fold;Armadillo-type fold;Abnormal spindle-like microcephaly-associated protein;IQ motif, EF-hand binding site;Abnormal spindle-like microcephaly-associated protein, ASH domain;Calponin homology domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs8922513 1482.0 Z [Z] Cytoskeleton; Q12805 EGF-containing fibulin-like extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=EFEMP1 PE=1 SV=2 - [FBLN3_HUMAN] 0.987 1.031 1.071 0.979 0.964 1.051 0.957322987 0.280328666 1.015560166 0.310384301 1.038797284 0.809921946 1.090248963 0.103077681 GO:0080090;GO:0019222;GO:0048468;GO:0006139;GO:0001501;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:1901362;GO:0031344;GO:0071840;GO:0031346;GO:0051716;GO:0048869;GO:0018212;GO:0018193;GO:0032331;GO:0032330;GO:0048513;GO:0010721;GO:0048518;GO:0048519;GO:0042127;GO:0060255;GO:0007601;GO:0007600;GO:0007173;GO:0010975;GO:2001141;GO:0003008;GO:0044700;GO:0051216;GO:0044707;GO:0048870;GO:0019538;GO:0030198;GO:0019438;GO:0048666;GO:0048563;GO:0048562;GO:0048569;GO:0048568;GO:0006928;GO:0051674;GO:0031175;GO:0050789;GO:0097659;GO:0044267;GO:0044260;GO:0014013;GO:0031345;GO:0046483;GO:0016043;GO:0065007;GO:1901360;GO:0016477;GO:0018130;GO:0051130;GO:0009887;GO:0009886;GO:0045665;GO:0050767;GO:0050793;GO:0009889;GO:0009888;GO:0050953;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0051239;GO:0034654;GO:0009059;GO:0016070;GO:0044271;GO:0007423;GO:0050896;GO:0006355;GO:0051961;GO:0051960;GO:2000145;GO:0006351;GO:0043010;GO:0051171;GO:0050768;GO:0008152;GO:0016310;GO:0030154;GO:0051129;GO:0051128;GO:0009791;GO:0009790;GO:0034641;GO:0023052;GO:0038127;GO:0034645;GO:0009653;GO:0044699;GO:0045664;GO:0051241;GO:0060284;GO:0032502;GO:0040011;GO:0032501;GO:0008283;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:0045596;GO:0045595;GO:0051270;GO:0001654;GO:0032879;GO:0051093;GO:0002062;GO:0051252;GO:0043170;GO:0006807;GO:0048731;GO:0008284;GO:0032774;GO:0030030;GO:0031326;GO:0031323;GO:0018108;GO:0090304;GO:0007275;GO:0048048;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0043062;GO:0010468;GO:0090596;GO:0048598;GO:0006468;GO:0030334;GO:0030182;GO:1901576;GO:0019219;GO:0048592;GO:0006464;GO:0061448;GO:0044767;GO:0061037;GO:0009058;GO:0061035;GO:0044763;GO:0048050;GO:1903975;GO:0007154;GO:0022008;GO:0051179;GO:0008347;GO:0042063;GO:0044238;GO:0048699;GO:0040012;GO:0007399;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:0006793;GO:0010977;GO:0044249;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;cell development;nucleobase-containing compound metabolic process;skeletal system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;organic cyclic compound biosynthetic process;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;cellular response to stimulus;cellular developmental process;peptidyl-tyrosine modification;peptidyl-amino acid modification;negative regulation of chondrocyte differentiation;regulation of chondrocyte differentiation;animal organ development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;visual perception;sensory perception;epidermal growth factor receptor signaling pathway;regulation of neuron projection development;regulation of RNA biosynthetic process;system process;single organism signaling;cartilage development;single-multicellular organism process;cell motility;protein metabolic process;extracellular matrix organization;aromatic compound biosynthetic process;neuron development;post-embryonic organ morphogenesis;embryonic organ morphogenesis;post-embryonic organ development;embryonic organ development;movement of cell or subcellular component;localization of cell;neuron projection development;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of gliogenesis;negative regulation of cell projection organization;heterocycle metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;cell migration;heterocycle biosynthetic process;positive regulation of cellular component organization;organ morphogenesis;post-embryonic morphogenesis;negative regulation of neuron differentiation;regulation of neurogenesis;regulation of developmental process;regulation of biosynthetic process;tissue development;sensory perception of light stimulus;regulation of cellular process;macromolecule modification;protein modification process;biological_process;regulation of multicellular organismal process;nucleobase-containing compound biosynthetic process;macromolecule biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;sensory organ development;response to stimulus;regulation of transcription, DNA-templated;negative regulation of nervous system development;regulation of nervous system development;regulation of cell motility;transcription, DNA-templated;camera-type eye development;regulation of nitrogen compound metabolic process;negative regulation of neurogenesis;metabolic process;phosphorylation;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;post-embryonic development;embryo development;cellular nitrogen compound metabolic process;signaling;ERBB signaling pathway;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;regulation of neuron differentiation;negative regulation of multicellular organismal process;regulation of cell development;developmental process;locomotion;multicellular organismal process;cell proliferation;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cellular component movement;eye development;regulation of localization;negative regulation of developmental process;chondrocyte differentiation;regulation of RNA metabolic process;macromolecule metabolic process;nitrogen compound metabolic process;system development;positive regulation of cell proliferation;RNA biosynthetic process;cell projection organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;nucleic acid metabolic process;multicellular organism development;embryonic eye morphogenesis;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;extracellular structure organization;regulation of gene expression;sensory organ morphogenesis;embryonic morphogenesis;protein phosphorylation;regulation of cell migration;neuron differentiation;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;eye morphogenesis;cellular protein modification process;connective tissue development;single-organism developmental process;negative regulation of cartilage development;biosynthetic process;regulation of cartilage development;single-organism cellular process;post-embryonic eye morphogenesis;regulation of glial cell migration;cell communication;neurogenesis;localization;glial cell migration;gliogenesis;primary metabolic process;generation of neurons;regulation of locomotion;nervous system development;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of neuron projection development;cellular biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;4;5;4;5;6;7;5;5;2;5;3;4;8;7;5;5;4;5;2;2;4;4;7;5;9;6;6;3;3;5;3;3;4;5;5;5;5;5;4;4;4;3;5;2;7;5;4;7;5;4;3;2;4;4;5;4;4;4;6;6;3;4;4;6;3;5;5;1;3;5;5;5;5;4;2;6;4;5;4;6;6;4;5;2;6;5;4;4;4;5;4;2;8;5;3;2;7;3;5;2;2;2;3;4;2;4;7;4;4;4;5;3;3;6;5;4;3;4;4;6;4;5;4;8;5;4;6;6;3;5;5;4;5;5;4;7;5;6;4;5;6;6;5;3;4;3;5;3;6;6;4;6;2;5;7;3;7;3;5;3;3;5;4;4;6;4;3;3; GO:0031982;GO:0031012;GO:0043230;GO:0044424;GO:0044420;GO:0044421;GO:0005622;GO:0043227;GO:0005737;GO:0044464;GO:0005623;GO:0005604;GO:0005615;GO:0043226;GO:1903561;GO:0070062;GO:0005575;GO:0005576;GO:0005578; vesicle;extracellular matrix;extracellular organelle;intracellular part;extracellular matrix component;extracellular region part;intracellular;membrane-bounded organelle;cytoplasm;cell part;cell;basement membrane;extracellular space;organelle;extracellular vesicle;extracellular exosome;cellular_component;extracellular region;proteinaceous extracellular matrix; 4;2;3;3;2;2;3;3;4;2;2;3;3;2;3;4;1;2;3; GO:0004714;GO:0004713;GO:0046872;GO:0005154;GO:0004672;GO:0099600;GO:0003674;GO:0005488;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0005006;GO:0038023;GO:0043169;GO:0016740;GO:0043167;GO:0005509;GO:0060089;GO:0005515;GO:0005102;GO:0004872;GO:0004871;GO:0004888;GO:0070851;GO:0019199; transmembrane receptor protein tyrosine kinase activity;protein tyrosine kinase activity;metal ion binding;epidermal growth factor receptor binding;protein kinase activity;transmembrane receptor activity;molecular_function;binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;epidermal growth factor-activated receptor activity;signaling receptor activity;cation binding;transferase activity;ion binding;calcium ion binding;molecular transducer activity;protein binding;receptor binding;receptor activity;signal transducer activity;transmembrane signaling receptor activity;growth factor receptor binding;transmembrane receptor protein kinase activity; 6;7;5;6;6;4;1;2;5;2;5;4;7;3;4;3;3;6;2;3;4;3;2;4;5;5; K18262 IPR000152;IPR018097;IPR009030;IPR000742;IPR026823;IPR001881;IPR013032;IPR032973; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Growth factor receptor cysteine-rich domain;EGF-like domain;Complement Clr-like EGF domain;EGF-like calcium-binding domain;EGF-like, conserved site;EGF-containing fibulin-like extracellular matrix protein 1; extracellular Hs9665262 1019.0 T [T] Signal transduction mechanisms; P56817 Beta-secretase 1 OS=Homo sapiens OX=9606 GN=BACE1 PE=1 SV=3 - [BACE1_HUMAN] 0.977 0.842 1.25 0.922 0.88 1.872 1.160332542 nan 1.047727273 nan 1.48456057 nan 2.127272727 nan GO:0071704;GO:1901564;GO:0019538;GO:0006807;GO:0044267;GO:1901575;GO:0044260;GO:0008150;GO:0006518;GO:0008152;GO:0033619;GO:0034641;GO:0050435;GO:0006509;GO:0006508;GO:0009987;GO:0043603;GO:0043170;GO:0009056;GO:0009057;GO:0044238;GO:0044237;GO:0030163; organic substance metabolic process;organonitrogen compound metabolic process;protein metabolic process;nitrogen compound metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;biological_process;peptide metabolic process;metabolic process;membrane protein proteolysis;cellular nitrogen compound metabolic process;beta-amyloid metabolic process;membrane protein ectodomain proteolysis;proteolysis;cellular process;cellular amide metabolic process;macromolecule metabolic process;catabolic process;macromolecule catabolic process;primary metabolic process;cellular metabolic process;protein catabolic process; 3;4;4;3;5;4;4;1;5;2;6;4;6;7;5;2;5;4;3;5;3;3;5; GO:0005783;GO:0005788;GO:0030424;GO:0070931;GO:0031984;GO:0031983;GO:0031982;GO:0016023;GO:0016021;GO:0005770;GO:0031988;GO:0005794;GO:0098588;GO:0005798;GO:0031974;GO:0042995;GO:0043231;GO:0043233;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044433;GO:0044432;GO:0044431;GO:0044437;GO:0012505;GO:0012506;GO:0044446;GO:0005773;GO:0044444;GO:0044440;GO:0005771;GO:0097708;GO:0016020;GO:0060205;GO:0031226;GO:0031224;GO:0010008;GO:0005737;GO:0031090;GO:0031410;GO:0043005;GO:0044459;GO:0009986;GO:0030659;GO:0005774;GO:0044464;GO:0005623;GO:0071944;GO:0098805;GO:0097458;GO:0005887;GO:0005886;GO:0005802;GO:0005575;GO:0070013;GO:0098791;GO:0005768; endoplasmic reticulum;endoplasmic reticulum lumen;axon;Golgi-associated vesicle lumen;organelle subcompartment;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;late endosome;membrane-bounded vesicle;Golgi apparatus;bounding membrane of organelle;Golgi-associated vesicle;membrane-enclosed lumen;cell projection;intracellular membrane-bounded organelle;organelle lumen;intracellular part;membrane part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasmic vesicle part;endoplasmic reticulum part;Golgi apparatus part;vacuolar part;endomembrane system;vesicle membrane;intracellular organelle part;vacuole;cytoplasmic part;endosomal part;multivesicular body;intracellular vesicle;membrane;cytoplasmic membrane-bounded vesicle lumen;intrinsic component of plasma membrane;intrinsic component of membrane;endosome membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;neuron projection;plasma membrane part;cell surface;cytoplasmic vesicle membrane;vacuolar membrane;cell part;cell;cell periphery;whole membrane;neuron part;integral component of plasma membrane;plasma membrane;trans-Golgi network;cellular_component;intracellular organelle lumen;Golgi subcompartment;endosome; 4;5;5;5;4;4;4;5;4;5;5;4;4;5;2;3;4;3;3;2;2;3;3;3;2;4;4;4;4;3;4;3;5;4;5;6;4;2;5;4;3;5;4;3;5;4;3;3;5;4;2;2;3;3;3;4;3;5;1;4;5;4; GO:0070001;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0001540;GO:0008798;GO:0019899;GO:0008238;GO:0008233;GO:0042277;GO:0033218;GO:0004190;GO:0005515;GO:0004175;GO:0008242;GO:0070011; aspartic-type peptidase activity;molecular_function;binding;hydrolase activity;catalytic activity;beta-amyloid binding;beta-aspartyl-peptidase activity;enzyme binding;exopeptidase activity;peptidase activity;peptide binding;amide binding;aspartic-type endopeptidase activity;protein binding;endopeptidase activity;omega peptidase activity;peptidase activity, acting on L-amino acid peptides; 6;1;2;3;2;5;8;4;6;4;4;3;7;3;6;7;5; K04521 map05010; Alzheimer's disease; IPR021109;IPR033874;IPR009120;IPR033121;IPR001461;IPR001969;IPR009119; Aspartic peptidase domain;Memapsin-like;Beta-secretase BACE1;Peptidase family A1 domain;Aspartic peptidase A1 family;Aspartic peptidase, active site;Beta-secretase BACE; peroxisome Hs6912266 1043.0 O [O] Posttranslational modification, protein turnover, chaperones; Q6R327 Rapamycin-insensitive companion of mTOR OS=Homo sapiens OX=9606 GN=RICTOR PE=1 SV=1 - [RICTR_HUMAN] 0.941 0.9 1.194 0.838 1.102 1.47 1.045555556 0.625254194 0.760435572 0.088195368 1.326666667 0.020246187 1.333938294 0.27323708 GO:0048010;GO:0019220;GO:0080090;GO:0019222;GO:0034110;GO:0048584;GO:0048583;GO:0008064;GO:0043933;GO:0007163;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0051897;GO:0051896;GO:0034112;GO:0065003;GO:0051716;GO:0030838;GO:0010604;GO:0045785;GO:0009966;GO:0009967;GO:0071840;GO:0033043;GO:0051493;GO:0070848;GO:0018193;GO:0044093;GO:0048518;GO:0002682;GO:0031295;GO:0031294;GO:0042127;GO:0038179;GO:0060255;GO:0042221;GO:0046649;GO:0007173;GO:0030041;GO:0050678;GO:0051128;GO:0010033;GO:0010467;GO:0042325;GO:0044700;GO:0042327;GO:0071593;GO:0018209;GO:0009605;GO:0044707;GO:0044089;GO:0019538;GO:0050730;GO:0010638;GO:0002376;GO:0050731;GO:0070489;GO:0032535;GO:0022607;GO:0070887;GO:0008284;GO:0045321;GO:0031334;GO:0035556;GO:0043170;GO:0050789;GO:0044267;GO:0002764;GO:0044260;GO:0008543;GO:0044344;GO:0016043;GO:0090066;GO:0070271;GO:0002684;GO:0065007;GO:0043085;GO:0018108;GO:0065009;GO:0045087;GO:0051130;GO:0098602;GO:0098609;GO:0050790;GO:0050794;GO:0006952;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0048011;GO:1902533;GO:0031347;GO:1902531;GO:0048015;GO:0048017;GO:0051336;GO:0044767;GO:0038095;GO:0038093;GO:0043491;GO:0050896;GO:0031401;GO:0006950;GO:0002694;GO:0002696;GO:0032008;GO:0071774;GO:0007159;GO:0009611;GO:0006954;GO:0032101;GO:0001775;GO:0016310;GO:0030155;GO:0032956;GO:0050727;GO:0023056;GO:0009790;GO:0023052;GO:0038127;GO:0030010;GO:0023051;GO:0010647;GO:0010646;GO:0043087;GO:0043254;GO:0044699;GO:0009893;GO:0009719;GO:0051249;GO:0030952;GO:0030950;GO:0043623;GO:0010562;GO:0051246;GO:0051247;GO:1903039;GO:0050673;GO:0032270;GO:0032271;GO:0031399;GO:0042110;GO:0022610;GO:1903034;GO:0031325;GO:1903037;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0031929;GO:0050870;GO:0050863;GO:0007010;GO:0032878;GO:0051258;GO:0032268;GO:0071363;GO:0050679;GO:0051251;GO:0002768;GO:0065008;GO:0080134;GO:0071495;GO:0018105;GO:0016337;GO:0050865;GO:0033135;GO:0050867;GO:0031323;GO:0030036;GO:0022407;GO:0034622;GO:0045937;GO:0007275;GO:0022409;GO:0030832;GO:0030833;GO:0071822;GO:0044087;GO:0031532;GO:2000114;GO:1902589;GO:0032273;GO:0071704;GO:0071310;GO:0044085;GO:0010468;GO:0006468;GO:0032970;GO:0050776;GO:0030029;GO:0034109;GO:0006461;GO:0006464;GO:0051174;GO:0044763;GO:0032006;GO:0007155;GO:0007154;GO:0070486;GO:0008154;GO:0006996;GO:0044238;GO:0007015;GO:0001936;GO:0048856;GO:0044237;GO:0018212;GO:0001938;GO:0006796;GO:0051495;GO:0006793;GO:0001932;GO:0001935;GO:0001934;GO:0048522; vascular endothelial growth factor receptor signaling pathway;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of homotypic cell-cell adhesion;positive regulation of response to stimulus;regulation of response to stimulus;regulation of actin polymerization or depolymerization;macromolecular complex subunit organization;establishment or maintenance of cell polarity;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;positive regulation of homotypic cell-cell adhesion;macromolecular complex assembly;cellular response to stimulus;positive regulation of actin filament polymerization;positive regulation of macromolecule metabolic process;positive regulation of cell adhesion;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;regulation of organelle organization;regulation of cytoskeleton organization;response to growth factor;peptidyl-amino acid modification;positive regulation of molecular function;positive regulation of biological process;regulation of immune system process;T cell costimulation;lymphocyte costimulation;regulation of cell proliferation;neurotrophin signaling pathway;regulation of macromolecule metabolic process;response to chemical;lymphocyte activation;epidermal growth factor receptor signaling pathway;actin filament polymerization;regulation of epithelial cell proliferation;regulation of cellular component organization;response to organic substance;gene expression;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;lymphocyte aggregation;peptidyl-serine modification;response to external stimulus;single-multicellular organism process;positive regulation of cellular component biogenesis;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;positive regulation of organelle organization;immune system process;positive regulation of peptidyl-tyrosine phosphorylation;T cell aggregation;regulation of cellular component size;cellular component assembly;cellular response to chemical stimulus;positive regulation of cell proliferation;leukocyte activation;positive regulation of protein complex assembly;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;fibroblast growth factor receptor signaling pathway;cellular response to fibroblast growth factor stimulus;cellular component organization;regulation of anatomical structure size;protein complex biogenesis;positive regulation of immune system process;biological regulation;positive regulation of catalytic activity;peptidyl-tyrosine phosphorylation;regulation of molecular function;innate immune response;positive regulation of cellular component organization;single organism cell adhesion;cell-cell adhesion;regulation of catalytic activity;regulation of cellular process;defense response;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;regulation of defense response;regulation of intracellular signal transduction;phosphatidylinositol-mediated signaling;inositol lipid-mediated signaling;regulation of hydrolase activity;single-organism developmental process;Fc-epsilon receptor signaling pathway;Fc receptor signaling pathway;protein kinase B signaling;response to stimulus;positive regulation of protein modification process;response to stress;regulation of leukocyte activation;positive regulation of leukocyte activation;positive regulation of TOR signaling;response to fibroblast growth factor;leukocyte cell-cell adhesion;response to wounding;inflammatory response;regulation of response to external stimulus;cell activation;phosphorylation;regulation of cell adhesion;regulation of actin cytoskeleton organization;regulation of inflammatory response;positive regulation of signaling;embryo development;signaling;ERBB signaling pathway;establishment of cell polarity;regulation of signaling;positive regulation of cell communication;regulation of cell communication;regulation of GTPase activity;regulation of protein complex assembly;single-organism process;positive regulation of metabolic process;response to endogenous stimulus;regulation of lymphocyte activation;establishment or maintenance of cytoskeleton polarity;establishment or maintenance of actin cytoskeleton polarity;cellular protein complex assembly;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of leukocyte cell-cell adhesion;epithelial cell proliferation;positive regulation of cellular protein metabolic process;regulation of protein polymerization;regulation of protein modification process;T cell activation;biological adhesion;regulation of response to wounding;positive regulation of cellular metabolic process;regulation of leukocyte cell-cell adhesion;developmental process;multicellular organismal process;cell proliferation;cellular process;TOR signaling;positive regulation of T cell activation;regulation of T cell activation;cytoskeleton organization;regulation of establishment or maintenance of cell polarity;protein polymerization;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;positive regulation of epithelial cell proliferation;positive regulation of lymphocyte activation;immune response-regulating cell surface receptor signaling pathway;regulation of biological quality;regulation of response to stress;cellular response to endogenous stimulus;peptidyl-serine phosphorylation;single organismal cell-cell adhesion;regulation of cell activation;regulation of peptidyl-serine phosphorylation;positive regulation of cell activation;regulation of cellular metabolic process;actin cytoskeleton organization;regulation of cell-cell adhesion;cellular macromolecular complex assembly;positive regulation of phosphate metabolic process;multicellular organism development;positive regulation of cell-cell adhesion;regulation of actin filament length;regulation of actin filament polymerization;protein complex subunit organization;regulation of cellular component biogenesis;actin cytoskeleton reorganization;regulation of establishment of cell polarity;single-organism organelle organization;positive regulation of protein polymerization;organic substance metabolic process;cellular response to organic substance;cellular component biogenesis;regulation of gene expression;protein phosphorylation;regulation of actin filament-based process;regulation of immune response;actin filament-based process;homotypic cell-cell adhesion;protein complex assembly;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;regulation of TOR signaling;cell adhesion;cell communication;leukocyte aggregation;actin polymerization or depolymerization;organelle organization;primary metabolic process;actin filament organization;regulation of endothelial cell proliferation;anatomical structure development;cellular metabolic process;peptidyl-tyrosine modification;positive regulation of endothelial cell proliferation;phosphate-containing compound metabolic process;positive regulation of cytoskeleton organization;phosphorus metabolic process;regulation of protein phosphorylation;endothelial cell proliferation;positive regulation of protein phosphorylation;positive regulation of cellular process; 8;6;4;3;6;3;3;6;4;4;4;5;6;7;6;6;6;5;3;6;4;4;4;4;2;5;6;5;7;4;2;3;4;3;4;6;4;3;4;9;8;5;4;4;5;7;3;7;7;8;3;3;3;4;8;5;2;8;4;4;4;4;4;3;4;5;4;2;5;5;4;6;5;3;4;4;3;2;5;8;3;4;4;3;4;4;3;4;5;5;1;2;3;7;5;5;5;7;6;5;3;8;7;6;2;6;3;4;4;6;4;5;4;5;4;4;6;4;5;5;3;5;2;8;5;3;4;4;6;4;2;3;3;5;5;6;6;5;5;5;6;4;5;5;6;5;2;5;4;6;2;2;3;2;6;6;6;5;4;7;5;6;5;5;6;3;4;4;8;4;4;8;4;4;5;5;6;6;4;5;5;6;5;3;6;5;4;5;3;5;3;5;7;4;4;4;5;5;6;5;3;6;3;4;6;7;4;3;6;6;3;3;8;6;5;6;4;7;5;7;3; GO:0038201;GO:0043234;GO:0005829;GO:0044424;GO:0005737;GO:0044444;GO:0031932;GO:0044464;GO:0005623;GO:0005622;GO:0032991;GO:0005575; TOR complex;protein complex;cytosol;intracellular part;cytoplasm;cytoplasmic part;TORC2 complex;cell part;cell;intracellular;macromolecular complex;cellular_component; 4;3;5;3;4;4;4;2;2;3;2;1; GO:0098772;GO:0019901;GO:0019900;GO:0003674;GO:0005488;GO:0043021;GO:0043022;GO:0019899;GO:0005515;GO:0044877;GO:0008047;GO:0030234; molecular function regulator;protein kinase binding;kinase binding;molecular_function;binding;ribonucleoprotein complex binding;ribosome binding;enzyme binding;protein binding;macromolecular complex binding;enzyme activator activity;enzyme regulator activity; 2;6;5;1;2;4;5;4;3;3;4;3; K08267 map04150; mTOR signaling pathway; IPR016024;IPR028268;IPR028267;IPR029259;IPR029451;IPR029452;IPR029453;IPR011989; Armadillo-type fold;Pianissimo family;Rapamycin-insensitive companion of mTOR, N-terminal domain;Rapamycin-insensitive companion of mTOR, phosphorylation-site;Rapamycin-insensitive companion of mTOR, middle domain;Rapamycin-insensitive companion of mTOR, domain 5;Rapamycin-insensitive companion of mTOR, domain 4;Armadillo-like helical; nucleus Hs22047806 508.0 D [D] Cell cycle control, cell division, chromosome partitioning; O60885 Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2 - [BRD4_HUMAN] 1.127 1.479 0.546 0.935 1.289 0.677 0.762001352 nan 0.725368503 nan 0.369168357 nan 0.525213344 nan GO:0019220;GO:0080090;GO:0019222;GO:0000086;GO:0048585;GO:0048584;GO:0048583;GO:0000083;GO:0007165;GO:1901362;GO:0071840;GO:0051716;GO:0045786;GO:0045787;GO:0009966;GO:0009967;GO:0032101;GO:0050727;GO:0044419;GO:0048518;GO:0048519;GO:0051704;GO:0043122;GO:0043123;GO:0060255;GO:0000082;GO:0032784;GO:0032786;GO:0010971;GO:2001141;GO:2001021;GO:2001020;GO:0046483;GO:0042325;GO:0044700;GO:0009605;GO:0019538;GO:1901407;GO:0007154;GO:2000001;GO:2000002;GO:0019438;GO:0016568;GO:0009893;GO:0009891;GO:0007249;GO:0023051;GO:0051254;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0007346;GO:0031570;GO:0016043;GO:0065007;GO:0044699;GO:0006366;GO:0006368;GO:0018130;GO:0033554;GO:0009889;GO:0050794;GO:0006952;GO:1901987;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:1902533;GO:0031347;GO:1902531;GO:1901989;GO:0016070;GO:0044271;GO:0050896;GO:0080135;GO:0070816;GO:0043412;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:1901977;GO:1901976;GO:0006954;GO:0032774;GO:0051246;GO:0016310;GO:0009611;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:1901990;GO:0034645;GO:1901992;GO:0010647;GO:0010646;GO:0032968;GO:0007049;GO:0006139;GO:0010564;GO:0031399;GO:1903034;GO:1903508;GO:0034243;GO:0090068;GO:0009987;GO:0006725;GO:1903506;GO:0006974;GO:0045893;GO:0044764;GO:0051276;GO:0090304;GO:0032268;GO:0006338;GO:0051252;GO:0044772;GO:1902680;GO:0010628;GO:0045944;GO:0080134;GO:0044839;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0010604;GO:1903047;GO:0044770;GO:0010948;GO:0022402;GO:0035556;GO:0006354;GO:0006325;GO:1901360;GO:2000112;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:1902751;GO:0045931;GO:0006468;GO:0045935;GO:0000278;GO:0044267;GO:0019219;GO:0006464;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044843;GO:0010389;GO:0006996;GO:0044238;GO:0000077;GO:0044260;GO:0000075;GO:0051726;GO:0044237;GO:0006796;GO:1902749;GO:0016032;GO:0006793;GO:0044403;GO:0001932;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;G2/M transition of mitotic cell cycle;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of transcription involved in G1/S transition of mitotic cell cycle;signal transduction;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of cell cycle;positive regulation of cell cycle;regulation of signal transduction;positive regulation of signal transduction;regulation of response to external stimulus;regulation of inflammatory response;interspecies interaction between organisms;positive regulation of biological process;negative regulation of biological process;multi-organism process;regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of macromolecule metabolic process;G1/S transition of mitotic cell cycle;regulation of DNA-templated transcription, elongation;positive regulation of DNA-templated transcription, elongation;positive regulation of G2/M transition of mitotic cell cycle;regulation of RNA biosynthetic process;negative regulation of response to DNA damage stimulus;regulation of response to DNA damage stimulus;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;response to external stimulus;protein metabolic process;regulation of phosphorylation of RNA polymerase II C-terminal domain;cell communication;regulation of DNA damage checkpoint;negative regulation of DNA damage checkpoint;aromatic compound biosynthetic process;chromatin modification;positive regulation of metabolic process;positive regulation of biosynthetic process;I-kappaB kinase/NF-kappaB signaling;regulation of signaling;positive regulation of RNA metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;regulation of mitotic cell cycle;DNA integrity checkpoint;cellular component organization;biological regulation;single-organism process;transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;heterocycle biosynthetic process;cellular response to stress;regulation of biosynthetic process;regulation of cellular process;defense response;regulation of cell cycle phase transition;response to stress;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of defense response;regulation of intracellular signal transduction;positive regulation of cell cycle phase transition;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of cellular response to stress;phosphorylation of RNA polymerase II C-terminal domain;macromolecule modification;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of cell cycle checkpoint;regulation of cell cycle checkpoint;inflammatory response;RNA biosynthetic process;regulation of protein metabolic process;phosphorylation;response to wounding;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of mitotic cell cycle phase transition;cellular macromolecule biosynthetic process;positive regulation of mitotic cell cycle phase transition;positive regulation of cell communication;regulation of cell communication;positive regulation of transcription elongation from RNA polymerase II promoter;cell cycle;nucleobase-containing compound metabolic process;regulation of cell cycle process;regulation of protein modification process;regulation of response to wounding;positive regulation of nucleic acid-templated transcription;regulation of transcription elongation from RNA polymerase II promoter;positive regulation of cell cycle process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;positive regulation of transcription, DNA-templated;multi-organism cellular process;chromosome organization;nucleic acid metabolic process;regulation of cellular protein metabolic process;chromatin remodeling;regulation of RNA metabolic process;mitotic cell cycle phase transition;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;regulation of response to stress;cell cycle G2/M phase transition;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of macromolecule metabolic process;mitotic cell cycle process;cell cycle phase transition;negative regulation of cell cycle process;cell cycle process;intracellular signal transduction;DNA-templated transcription, elongation;chromatin organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of cell cycle G2/M phase transition;positive regulation of mitotic cell cycle;protein phosphorylation;positive regulation of nucleobase-containing compound metabolic process;mitotic cell cycle;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell cycle G1/S phase transition;regulation of G2/M transition of mitotic cell cycle;organelle organization;primary metabolic process;DNA damage checkpoint;cellular macromolecule metabolic process;cell cycle checkpoint;regulation of cell cycle;cellular metabolic process;phosphate-containing compound metabolic process;regulation of cell cycle G2/M phase transition;viral process;phosphorus metabolic process;symbiosis, encompassing mutualism through parasitism;regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;6;3;3;3;6;4;5;2;3;4;4;4;4;4;5;3;2;2;2;6;6;4;7;7;7;7;6;4;5;4;7;3;3;4;8;4;6;5;5;6;3;4;6;3;5;3;4;2;7;4;5;6;3;2;2;7;8;5;4;4;3;4;6;3;5;1;2;5;5;5;5;6;5;5;2;4;8;5;6;5;5;6;6;6;5;6;5;6;4;3;4;4;2;6;5;6;4;4;8;4;4;5;6;5;7;8;5;2;4;7;5;6;3;5;5;5;7;5;6;6;5;7;4;6;5;4;5;4;4;4;5;5;5;4;5;7;5;4;6;3;5;7;5;7;5;7;5;5;5;5;6;5;3;5;3;4;4;6;7;4;3;6;4;5;4;3;5;7;4;4;4;7;3;3; GO:0031974;GO:0043228;GO:0031981;GO:0044422;GO:0000793;GO:0000794;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0043232;GO:0043229;GO:0000228;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005694;GO:0005575;GO:0070013; membrane-enclosed lumen;non-membrane-bounded organelle;nuclear lumen;organelle part;condensed chromosome;condensed nuclear chromosome;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;intracellular non-membrane-bounded organelle;intracellular organelle;nuclear chromosome;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;intracellular;organelle;chromosome;cellular_component;intracellular organelle lumen; 2;3;5;2;6;6;4;3;4;3;4;3;5;3;5;3;4;5;2;2;3;2;5;1;4; GO:0042393;GO:0003674;GO:0005488;GO:0070577;GO:0005515;GO:0044877;GO:0003682;GO:0002039; histone binding;molecular_function;binding;lysine-acetylated histone binding;protein binding;macromolecular complex binding;chromatin binding;p53 binding; 4;1;2;5;3;3;4;4; K11722 IPR018359;IPR001487;IPR031354;IPR027353; Bromodomain, conserved site;Bromodomain;Bromodomain protein 4, C-terminal;NET domain; nucleus Hs19718731 2686.0 K [K] Transcription; Q9GZV4 Eukaryotic translation initiation factor 5A-2 OS=Homo sapiens OX=9606 GN=EIF5A2 PE=1 SV=3 - [IF5A2_HUMAN] 1.026 0.87 1.381 0.903 0.846 1.214 1.179310345 nan 1.067375887 nan 1.587356322 nan 1.43498818 nan GO:0045905;GO:0008104;GO:0080090;GO:0019222;GO:0071840;GO:0010604;GO:0010608;GO:0043043;GO:0048518;GO:0033036;GO:0042127;GO:0006448;GO:0006449;GO:0060255;GO:0045184;GO:1901564;GO:1901566;GO:0019538;GO:0006452;GO:0009893;GO:0009891;GO:0006807;GO:0051028;GO:0043170;GO:0050789;GO:0044267;GO:0044260;GO:0016043;GO:0065007;GO:0043243;GO:0045727;GO:0051130;GO:0006810;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0051236;GO:0051234;GO:0050658;GO:0044271;GO:0050657;GO:0010557;GO:0010556;GO:0044763;GO:0006518;GO:0034250;GO:0015931;GO:0045901;GO:0051128;GO:0044249;GO:0034641;GO:0034645;GO:0043244;GO:0043241;GO:0044699;GO:0051246;GO:0051247;GO:0032270;GO:0008284;GO:0008283;GO:0009987;GO:0034248;GO:0043604;GO:0032268;GO:0043603;GO:0010628;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0032984;GO:0071822;GO:2000112;GO:0071705;GO:0071704;GO:0010467;GO:0071702;GO:0006403;GO:0010468;GO:1901576;GO:0015031;GO:0009058;GO:0009059;GO:0022411;GO:0051171;GO:0051173;GO:0043624;GO:0051179;GO:0044238;GO:0044237;GO:0006417;GO:0006415;GO:0006414;GO:0006412;GO:0048522; positive regulation of translational termination;protein localization;regulation of primary metabolic process;regulation of metabolic process;cellular component organization or biogenesis;positive regulation of macromolecule metabolic process;posttranscriptional regulation of gene expression;peptide biosynthetic process;positive regulation of biological process;macromolecule localization;regulation of cell proliferation;regulation of translational elongation;regulation of translational termination;regulation of macromolecule metabolic process;establishment of protein localization;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;translational frameshifting;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;mRNA transport;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;positive regulation of protein complex disassembly;positive regulation of translation;positive regulation of cellular component organization;transport;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;establishment of RNA localization;establishment of localization;RNA transport;cellular nitrogen compound biosynthetic process;nucleic acid transport;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;single-organism cellular process;peptide metabolic process;positive regulation of cellular amide metabolic process;nucleobase-containing compound transport;positive regulation of translational elongation;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;regulation of protein complex disassembly;protein complex disassembly;single-organism process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;positive regulation of cell proliferation;cell proliferation;cellular process;regulation of cellular amide metabolic process;amide biosynthetic process;regulation of cellular protein metabolic process;cellular amide metabolic process;positive regulation of gene expression;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;macromolecular complex disassembly;protein complex subunit organization;regulation of cellular macromolecule biosynthetic process;nitrogen compound transport;organic substance metabolic process;gene expression;organic substance transport;RNA localization;regulation of gene expression;organic substance biosynthetic process;protein transport;biosynthetic process;macromolecule biosynthetic process;cellular component disassembly;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cellular protein complex disassembly;localization;primary metabolic process;cellular metabolic process;regulation of translation;translational termination;translational elongation;translation;positive regulation of cellular process; 6;4;4;3;2;4;6;6;2;3;4;7;6;4;4;4;5;4;7;3;4;3;6;4;2;5;4;3;2;5;6;4;4;4;3;1;2;4;3;5;5;7;5;5;3;5;5;6;7;4;4;4;5;5;6;2;5;5;5;4;3;2;5;6;5;5;5;5;4;5;4;4;5;5;6;5;3;5;5;4;5;4;5;3;5;4;4;4;7;2;3;3;6;7;6;6;3; GO:0031975;GO:0005783;GO:0016020;GO:0098588;GO:0031967;GO:0005789;GO:0043231;GO:0042175;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0012505;GO:0005643;GO:0044446;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005622;GO:0044444;GO:0043226;GO:0005575; envelope;endoplasmic reticulum;membrane;bounding membrane of organelle;organelle envelope;endoplasmic reticulum membrane;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;nuclear part;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;endomembrane system;nuclear pore;intracellular organelle part;cytoplasm;organelle membrane;nucleus;nuclear envelope;cell part;cell;intracellular;cytoplasmic part;organelle;cellular_component; 3;4;2;4;4;3;4;3;4;3;2;2;3;3;4;3;5;3;4;3;5;4;2;2;3;4;2;1; GO:1901363;GO:0043022;GO:0003674;GO:0005488;GO:0003676;GO:0043021;GO:0097159;GO:0003723;GO:0044877;GO:0008135;GO:0003746; heterocyclic compound binding;ribosome binding;molecular_function;binding;nucleic acid binding;ribonucleoprotein complex binding;organic cyclic compound binding;RNA binding;macromolecular complex binding;translation factor activity, RNA binding;translation elongation factor activity; 3;5;1;2;4;4;3;5;3;6;7; K03263 IPR014722;IPR019769;IPR020189;IPR012340;IPR008991;IPR001884; Ribosomal protein L2 domain 2;Translation elongation factor, IF5A, hypusine site;Translation elongation factor, IF5A C-terminal;Nucleic acid-binding, OB-fold;Translation protein SH3-like domain;Translation elongation factor IF5A; cytosol Hs9966867 317.0 J [J] Translation, ribosomal structure and biogenesis; Q9P0K8 Forkhead box protein J2 OS=Homo sapiens OX=9606 GN=FOXJ2 PE=1 SV=1 - [FOXJ2_HUMAN] 0.919 0.945 0.885 1.265 0.866 2.366 0.972486772 nan 1.46073903 nan 0.936507937 nan 2.732101617 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010604;GO:0048869;GO:0048518;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0051254;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0034645;GO:0009653;GO:0044699;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:1902680;GO:0045944;GO:0032502;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0010628;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045935;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044238;GO:0048856;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;cellular developmental process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;developmental process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of gene expression;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;anatomical structure development;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;4;2;4;6;4;5;3;4;5;3;4;7;4;4;2;7;5;4;3;1;2;5;5;5;6;5;7;6;6;5;4;4;5;3;2;4;7;2;4;7;6;5;6;7;2;5;5;4;4;5;5;6;2;3;5;5;5;5;5;3;3;5;3;4;4;3;3;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044446;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;intracellular organelle part;nucleolus;nucleus;cell part;cell;intracellular;non-membrane-bounded organelle;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;2;3;3;2;3;5;5;2;2;3;3;1;4; GO:0001077;GO:0001071;GO:1901363;GO:0001067;GO:0044212;GO:0001012;GO:0001159;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000987;GO:0000982;GO:0000981;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:0000978;GO:1990837;GO:0003690;GO:0042802;GO:0001228;GO:0005515;GO:0000977;GO:0003700; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter proximal region sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;identical protein binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;protein binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 6;2;3;5;7;8;8;1;2;4;5;9;5;4;6;3;8;6;10;7;6;4;5;3;9;3; K09403 IPR030456;IPR001766;IPR011991; Fork head domain conserved site 2;Fork head domain;Winged helix-turn-helix DNA-binding domain; nucleus Hs8923842 1170.0 K [K] Transcription; P13637 Sodium/potassium-transporting ATPase subunit alpha-3 OS=Homo sapiens OX=9606 GN=ATP1A3 PE=1 SV=3 - [AT1A3_HUMAN] 1 1.06 0.995 0.956 1.105 1.227 0.943396226 0.316458434 0.865158371 0.230148657 0.938679245 0.341719411 1.11040724 0.298392895 GO:1903779;GO:0007612;GO:0007613;GO:0007610;GO:0007611;GO:0003013;GO:0055075;GO:0003015;GO:0007166;GO:0035235;GO:0071436;GO:0051716;GO:0035725;GO:0098662;GO:0019725;GO:0006936;GO:0010248;GO:0010033;GO:0003008;GO:0044700;GO:0044707;GO:0044708;GO:0003012;GO:0048878;GO:0007154;GO:0071407;GO:0007165;GO:0007632;GO:1903416;GO:0042493;GO:0006818;GO:0098771;GO:0055078;GO:0015992;GO:0015991;GO:0060048;GO:0007626;GO:0006883;GO:0006813;GO:0065007;GO:0014070;GO:0098660;GO:0065008;GO:0009719;GO:0006810;GO:0008015;GO:0006812;GO:0006811;GO:0008016;GO:0050794;GO:0008306;GO:0008150;GO:0051239;GO:0051234;GO:0071804;GO:0006941;GO:0050896;GO:0050890;GO:0015988;GO:1903522;GO:0035637;GO:1902600;GO:0009314;GO:0050801;GO:0055065;GO:0060047;GO:0023052;GO:0070887;GO:0023051;GO:0010644;GO:0007215;GO:0008542;GO:0044699;GO:0036376;GO:0044057;GO:0071805;GO:0015672;GO:0071495;GO:0032501;GO:0030534;GO:0006875;GO:0050877;GO:0009987;GO:0071396;GO:0006873;GO:0030004;GO:0032870;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0055085;GO:0009725;GO:0048545;GO:0071383;GO:0042592;GO:0010107;GO:0086064;GO:0086065;GO:0033993;GO:0006814;GO:0050789;GO:0071310;GO:0061337;GO:0008344;GO:0090662;GO:0034220;GO:0044765;GO:0044763;GO:0055067;GO:0042221;GO:0051179;GO:1902578;GO:1901700;GO:0009628;GO:0009416;GO:0030007;GO:0098655; regulation of cardiac conduction;learning;memory;behavior;learning or memory;circulatory system process;potassium ion homeostasis;heart process;cell surface receptor signaling pathway;ionotropic glutamate receptor signaling pathway;sodium ion export;cellular response to stimulus;sodium ion transmembrane transport;inorganic cation transmembrane transport;cellular homeostasis;muscle contraction;establishment or maintenance of transmembrane electrochemical gradient;response to organic substance;system process;single organism signaling;single-multicellular organism process;single-organism behavior;muscle system process;chemical homeostasis;cell communication;cellular response to organic cyclic compound;signal transduction;visual behavior;response to glycoside;response to drug;hydrogen transport;inorganic ion homeostasis;sodium ion homeostasis;proton transport;ATP hydrolysis coupled proton transport;cardiac muscle contraction;locomotory behavior;cellular sodium ion homeostasis;potassium ion transport;biological regulation;response to organic cyclic compound;inorganic ion transmembrane transport;regulation of biological quality;response to endogenous stimulus;transport;blood circulation;cation transport;ion transport;regulation of heart contraction;regulation of cellular process;associative learning;biological_process;regulation of multicellular organismal process;establishment of localization;cellular potassium ion transport;striated muscle contraction;response to stimulus;cognition;energy coupled proton transmembrane transport, against electrochemical gradient;regulation of blood circulation;multicellular organismal signaling;hydrogen ion transmembrane transport;response to radiation;ion homeostasis;metal ion homeostasis;heart contraction;signaling;cellular response to chemical stimulus;regulation of signaling;cell communication by electrical coupling;glutamate receptor signaling pathway;visual learning;single-organism process;sodium ion export from cell;regulation of system process;potassium ion transmembrane transport;monovalent inorganic cation transport;cellular response to endogenous stimulus;multicellular organismal process;adult behavior;cellular metal ion homeostasis;neurological system process;cellular process;cellular response to lipid;cellular ion homeostasis;cellular monovalent inorganic cation homeostasis;cellular response to hormone stimulus;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;response to hormone;response to steroid hormone;cellular response to steroid hormone stimulus;homeostatic process;potassium ion import;cell communication by electrical coupling involved in cardiac conduction;cell communication involved in cardiac conduction;response to lipid;sodium ion transport;regulation of biological process;cellular response to organic substance;cardiac conduction;adult locomotory behavior;ATP hydrolysis coupled transmembrane transport;ion transmembrane transport;single-organism transport;single-organism cellular process;monovalent inorganic cation homeostasis;response to chemical;localization;single-organism localization;response to oxygen-containing compound;response to abiotic stimulus;response to light stimulus;cellular potassium ion homeostasis;cation transmembrane transport; 4;5;5;2;4;4;9;5;5;7;9;3;8;7;4;5;6;4;3;3;3;3;4;5;4;6;4;4;5;4;5;7;9;6;6;7;3;9;8;2;5;6;3;3;4;5;6;5;6;3;6;1;3;3;4;6;2;5;8;5;4;7;4;6;8;6;2;4;3;5;6;5;2;10;4;5;7;4;2;4;8;4;2;6;6;8;5;7;7;7;5;4;4;5;6;4;6;6;5;5;8;2;5;5;4;5;5;4;3;8;3;2;3;4;3;5;9;6; GO:0005783;GO:0031224;GO:0090533;GO:0044326;GO:0031982;GO:0043209;GO:0016021;GO:0016020;GO:0005794;GO:1902495;GO:1902494;GO:0030425;GO:0042995;GO:0043234;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044327;GO:0043229;GO:0043227;GO:0043226;GO:0042383;GO:1990351;GO:0012505;GO:0044444;GO:0098533;GO:0031226;GO:0005737;GO:0005634;GO:0044456;GO:0043005;GO:0044459;GO:1904949;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0005890;GO:0071944;GO:0045202;GO:0005575;GO:0044309;GO:0097458;GO:0005576;GO:0030424;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0043197;GO:0098797;GO:0098796;GO:0098794;GO:0036477; endoplasmic reticulum;intrinsic component of membrane;cation-transporting ATPase complex;dendritic spine neck;vesicle;myelin sheath;integral component of membrane;membrane;Golgi apparatus;transmembrane transporter complex;catalytic complex;dendrite;cell projection;protein complex;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;dendritic spine head;intracellular organelle;membrane-bounded organelle;organelle;sarcolemma;transporter complex;endomembrane system;cytoplasmic part;ATPase dependent transmembrane transport complex;intrinsic component of plasma membrane;cytoplasm;nucleus;synapse part;neuron projection;plasma membrane part;ATPase complex;cell projection part;cell part;cell;intracellular;sodium:potassium-exchanging ATPase complex;cell periphery;synapse;cellular_component;neuron spine;neuron part;extracellular region;axon;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;dendritic spine;plasma membrane protein complex;membrane protein complex;postsynapse;somatodendritic compartment; 4;3;4;3;4;3;4;2;4;4;4;5;3;3;3;4;3;2;2;3;3;3;2;4;4;3;4;3;4;4;5;2;4;3;5;3;2;2;3;5;3;2;1;5;3;2;5;4;3;3;2;4;4;3;3;4; GO:1901363;GO:1990239;GO:0015399;GO:0000166;GO:0035639;GO:0046873;GO:0046872;GO:0032549;GO:0005496;GO:0016818;GO:0097367;GO:0005524;GO:0016787;GO:0016817;GO:0003674;GO:0005488;GO:0019829;GO:1901265;GO:0042562;GO:0042625;GO:0042626;GO:0005391;GO:0017076;GO:0022804;GO:0003824;GO:0008556;GO:0015081;GO:0022891;GO:0022890;GO:0022892;GO:0097159;GO:0015405;GO:0015075;GO:0016462;GO:0032559;GO:0032555;GO:0015662;GO:0015079;GO:0032550;GO:0032553;GO:0043169;GO:0016820;GO:0051087;GO:0043167;GO:0008289;GO:0086037;GO:0030554;GO:0005515;GO:0043492;GO:0016887;GO:0036094;GO:0001883;GO:0001882;GO:0015077;GO:0005215;GO:0008324;GO:0017111;GO:0043168;GO:0022857;GO:0022853;GO:0042623; heterocyclic compound binding;steroid hormone binding;primary active transmembrane transporter activity;nucleotide binding;purine ribonucleoside triphosphate binding;metal ion transmembrane transporter activity;metal ion binding;ribonucleoside binding;steroid binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;ATP binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;molecular_function;binding;cation-transporting ATPase activity;nucleoside phosphate binding;hormone binding;ATPase coupled ion transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of substances;sodium:potassium-exchanging ATPase activity;purine nucleotide binding;active transmembrane transporter activity;catalytic activity;potassium-transporting ATPase activity;sodium ion transmembrane transporter activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;organic cyclic compound binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;ion transmembrane transporter activity;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;potassium ion transmembrane transporter activity;purine ribonucleoside binding;ribonucleotide binding;cation binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;chaperone binding;ion binding;lipid binding;sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential;adenyl nucleotide binding;protein binding;ATPase activity, coupled to movement of substances;ATPase activity;small molecule binding;purine nucleoside binding;nucleoside binding;monovalent inorganic cation transmembrane transporter activity;transporter activity;cation transmembrane transporter activity;nucleoside-triphosphatase activity;anion binding;transmembrane transporter activity;active ion transmembrane transporter activity;ATPase activity, coupled; 3;4;5;4;5;8;5;5;4;5;3;6;3;4;1;2;7;4;3;6;6;9;5;4;2;8;9;4;7;3;3;6;5;6;6;5;7;9;6;4;4;5;4;3;3;10;6;3;10;8;3;5;4;8;2;6;7;4;3;5;9; K01539 map04022;map04024;map04260;map04261;map04911;map04918;map04919;map04960;map04961;map04964;map04970;map04971;map04972;map04973;map04974;map04976;map04978; cGMP-PKG signaling pathway;cAMP signaling pathway;Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Insulin secretion;Thyroid hormone synthesis;Thyroid hormone signaling pathway;Aldosterone-regulated sodium reabsorption;Endocrine and other factor-regulated calcium reabsorption;Proximal tubule bicarbonate reclamation;Salivary secretion;Gastric acid secretion;Pancreatic secretion;Carbohydrate digestion and absorption;Protein digestion and absorption;Bile secretion;Mineral absorption; IPR018303;IPR023298;IPR023299;IPR004014;IPR006068;IPR023214;IPR008250;IPR005775;IPR001757; P-type ATPase, phosphorylation site;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;Cation-transporting P-type ATPase, N-terminal;Cation-transporting P-type ATPase, C-terminal;HAD-like domain;P-type ATPase, A domain;P-type ATPase subfamily IIC, subunit alpha;P-type ATPase; plasma membrane Hs14756299 2099.0 P [P] Inorganic ion transport and metabolism; Q8IYT3 Coiled-coil domain-containing protein 170 OS=Homo sapiens OX=9606 GN=CCDC170 PE=1 SV=3 - [CC170_HUMAN] 2.465 0.582 0.868 0.396 0.606 1.182 4.235395189 nan 0.653465347 nan 1.491408935 nan 1.95049505 nan cytosol Q6ISU1 Pre T-cell antigen receptor alpha OS=Homo sapiens OX=9606 GN=PTCRA PE=1 SV=1 - [PTCRA_HUMAN] nan nan nan nan nan nan nan 0.000192709 nan 0.042849538 nan 0.109303979 nan 0.226248036 GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; K06056 map04330;map05202; Notch signaling pathway;Transcriptional misregulation in cancer; IPR027834;IPR007110;IPR013783; Pre-T-cell antigen receptor;Immunoglobulin-like domain;Immunoglobulin-like fold; plasma membrane P60709 Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=ACTB PE=1 SV=1 - [ACTB_HUMAN] 1.017 1.11 0.835 1.196 1.106 1.253 0.916216216 0.198487531 1.081374322 0.552138082 0.752252252 0.175144221 1.132911392 0.716159024 GO:0043229;GO:0043228;GO:0005924;GO:0005925;GO:0030054;GO:0030055;GO:0005856;GO:0016020;GO:0097433;GO:0043226;GO:0005737;GO:0070161;GO:0005912;GO:0005886;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0071944;GO:0044424; intracellular organelle;non-membrane-bounded organelle;cell-substrate adherens junction;focal adhesion;cell junction;cell-substrate junction;cytoskeleton;membrane;dense body;organelle;cytoplasm;anchoring junction;adherens junction;plasma membrane;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;cell periphery;intracellular part; 3;3;4;5;2;3;5;2;5;2;4;3;4;3;4;2;2;3;1;4;3;3; GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0001883;GO:0043168;GO:0043167;GO:1901265;GO:0032549;GO:0017076;GO:0001882;GO:0005524;GO:0000166;GO:0036094;GO:0032555;GO:0030554;GO:0097367;GO:0097159;GO:0032559;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;purine nucleoside binding;anion binding;ion binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;nucleoside binding;ATP binding;nucleotide binding;small molecule binding;purine ribonucleotide binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;3;1;2;5;4;3;4;5;5;4;6;4;3;5;6;3;3;6;6;4; K05692 map04015;map04145;map04210;map04390;map04391;map04510;map04520;map04530;map04611;map04670;map04745;map04810;map04919;map04921;map05100;map05110;map05130;map05131;map05132;map05164;map05205;map05410;map05412;map05414;map05416; Rap1 signaling pathway;Phagosome;Apoptosis;Hippo signaling pathway;Hippo signaling pathway - fly;Focal adhesion;Adherens junction;Tight junction;Platelet activation;Leukocyte transendothelial migration;Phototransduction - fly;Regulation of actin cytoskeleton;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Bacterial invasion of epithelial cells;Vibrio cholerae infection;Pathogenic Escherichia coli infection;Shigellosis;Salmonella infection;Influenza A;Proteoglycans in cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Viral myocarditis; IPR020902;IPR004000;IPR004001; Actin/actin-like conserved site;Actin family;Actin, conserved site; cytoskeleton Hs4501885 785.0 Z [Z] Cytoskeleton; P18428 Lipopolysaccharide-binding protein OS=Homo sapiens OX=9606 GN=LBP PE=1 SV=3 - [LBP_HUMAN] 1.163 0.928 1.068 0.944 0.845 1.712 1.253232759 nan 1.117159763 nan 1.150862069 nan 2.026035503 nan GO:0009595;GO:0044238;GO:0009593;GO:0080090;GO:0019222;GO:0051049;GO:0048584;GO:0048583;GO:0031349;GO:0001816;GO:0050920;GO:0050921;GO:0007166;GO:0060326;GO:0006909;GO:0010556;GO:0031347;GO:0051716;GO:0050729;GO:0043207;GO:0042534;GO:0042535;GO:0009617;GO:0050727;GO:0010033;GO:0044419;GO:0048513;GO:0048518;GO:0048519;GO:0051704;GO:0032602;GO:0016192;GO:0032720;GO:0030595;GO:0098581;GO:0030593;GO:0006935;GO:0051050;GO:0060255;GO:0006869;GO:0002679;GO:0010876;GO:0060099;GO:0051128;GO:0051707;GO:0044146;GO:0044144;GO:0061024;GO:0044700;GO:0065008;GO:0009607;GO:0009605;GO:0044707;GO:0048870;GO:0019538;GO:0031663;GO:0002275;GO:0002274;GO:0002376;GO:0007154;GO:0043032;GO:0042035;GO:0043030;GO:0007165;GO:0033036;GO:0044116;GO:0060263;GO:0060264;GO:0060265;GO:1905153;GO:0061008;GO:0010647;GO:0023051;GO:0050867;GO:0006928;GO:0008152;GO:0045321;GO:1902624;GO:0051674;GO:0002685;GO:0042742;GO:1903555;GO:0050829;GO:0032496;GO:0032490;GO:0050789;GO:0044130;GO:0042108;GO:1901576;GO:0002281;GO:0002764;GO:0002232;GO:0010646;GO:0016043;GO:0002687;GO:0002684;GO:0002366;GO:0065007;GO:0071840;GO:0071219;GO:0071216;GO:0034145;GO:0016477;GO:0042089;GO:0042107;GO:0002688;GO:0051130;GO:0032760;GO:1901264;GO:0002532;GO:0006810;GO:0009889;GO:0044710;GO:0050794;GO:0006952;GO:0043903;GO:0006950;GO:0043901;GO:0008150;GO:0006954;GO:0006955;GO:0002526;GO:0044126;GO:0002523;GO:0010604;GO:0002757;GO:0051606;GO:0042330;GO:0006953;GO:0002696;GO:0051241;GO:0050896;GO:0002758;GO:0043900;GO:0002218;GO:0002697;GO:0045730;GO:2000145;GO:0002690;GO:2000147;GO:0009967;GO:0008228;GO:0002699;GO:0002263;GO:0032103;GO:0032101;GO:0001775;GO:0034143;GO:0009611;GO:0044110;GO:0044249;GO:0023052;GO:0070887;GO:0044117;GO:0045926;GO:0042533;GO:0044699;GO:0009893;GO:0050766;GO:0032640;GO:0051234;GO:0051240;GO:0060267;GO:0051246;GO:0051247;GO:0032642;GO:0044765;GO:0050865;GO:0097530;GO:0002224;GO:1903034;GO:0002221;GO:1903036;GO:0032677;GO:0032502;GO:0040011;GO:0032501;GO:0023056;GO:0051272;GO:0009987;GO:0071396;GO:1905155;GO:0060627;GO:1903556;GO:1903557;GO:0051270;GO:0098542;GO:0060100;GO:0032879;GO:0009891;GO:0050776;GO:0034123;GO:0032722;GO:0050778;GO:0043170;GO:0051239;GO:0001817;GO:0002237;GO:0032675;GO:0048731;GO:0048732;GO:0097529;GO:0080134;GO:0001818;GO:0001819;GO:0006968;GO:0071222;GO:0071223;GO:0031328;GO:0042116;GO:0031326;GO:0031325;GO:1990266;GO:0031323;GO:0050900;GO:0001889;GO:0006897;GO:0050764;GO:0007275;GO:0034121;GO:0002682;GO:0040007;GO:0090023;GO:0090022;GO:0033993;GO:0040008;GO:0015920;GO:0010557;GO:0071704;GO:0071310;GO:0071706;GO:0002536;GO:0071702;GO:0071622;GO:0090559;GO:0071621;GO:0002694;GO:0071624;GO:0030335;GO:0030334;GO:0045089;GO:0045088;GO:0032635;GO:0045087;GO:0032637;GO:1902622;GO:0006911;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0009966;GO:0042221;GO:0030100;GO:0051179;GO:1902578;GO:1901700;GO:1901701;GO:0034142;GO:0040012;GO:0040017;GO:0010324;GO:0048856;GO:0050830;GO:0044237;GO:0070391;GO:0032680;GO:0002253;GO:0002252;GO:0044403;GO:0045807;GO:0032757;GO:0032755;GO:0048522; detection of biotic stimulus;primary metabolic process;detection of chemical stimulus;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;cytokine production;regulation of chemotaxis;positive regulation of chemotaxis;cell surface receptor signaling pathway;cell chemotaxis;phagocytosis;regulation of macromolecule biosynthetic process;regulation of defense response;cellular response to stimulus;positive regulation of inflammatory response;response to external biotic stimulus;regulation of tumor necrosis factor biosynthetic process;positive regulation of tumor necrosis factor biosynthetic process;response to bacterium;regulation of inflammatory response;response to organic substance;interspecies interaction between organisms;animal organ development;positive regulation of biological process;negative regulation of biological process;multi-organism process;chemokine production;vesicle-mediated transport;negative regulation of tumor necrosis factor production;leukocyte chemotaxis;detection of external biotic stimulus;neutrophil chemotaxis;chemotaxis;positive regulation of transport;regulation of macromolecule metabolic process;lipid transport;respiratory burst involved in defense response;lipid localization;regulation of phagocytosis, engulfment;regulation of cellular component organization;response to other organism;negative regulation of growth of symbiont involved in interaction with host;modulation of growth of symbiont involved in interaction with host;membrane organization;single organism signaling;regulation of biological quality;response to biotic stimulus;response to external stimulus;single-multicellular organism process;cell motility;protein metabolic process;lipopolysaccharide-mediated signaling pathway;myeloid cell activation involved in immune response;myeloid leukocyte activation;immune system process;cell communication;positive regulation of macrophage activation;regulation of cytokine biosynthetic process;regulation of macrophage activation;signal transduction;macromolecule localization;growth of symbiont involved in interaction with host;regulation of respiratory burst;regulation of respiratory burst involved in inflammatory response;positive regulation of respiratory burst involved in inflammatory response;regulation of membrane invagination;hepaticobiliary system development;positive regulation of cell communication;regulation of signaling;positive regulation of cell activation;movement of cell or subcellular component;metabolic process;leukocyte activation;positive regulation of neutrophil migration;localization of cell;regulation of leukocyte migration;defense response to bacterium;regulation of tumor necrosis factor superfamily cytokine production;defense response to Gram-negative bacterium;response to lipopolysaccharide;detection of molecule of bacterial origin;regulation of biological process;negative regulation of growth of symbiont in host;positive regulation of cytokine biosynthetic process;organic substance biosynthetic process;macrophage activation involved in immune response;immune response-regulating signaling pathway;leukocyte chemotaxis involved in inflammatory response;regulation of cell communication;cellular component organization;positive regulation of leukocyte migration;positive regulation of immune system process;leukocyte activation involved in immune response;biological regulation;cellular component organization or biogenesis;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;positive regulation of toll-like receptor 4 signaling pathway;cell migration;cytokine biosynthetic process;cytokine metabolic process;regulation of leukocyte chemotaxis;positive regulation of cellular component organization;positive regulation of tumor necrosis factor production;carbohydrate derivative transport;production of molecular mediator involved in inflammatory response;transport;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;response to stress;negative regulation of multi-organism process;biological_process;inflammatory response;immune response;acute inflammatory response;regulation of growth of symbiont in host;leukocyte migration involved in inflammatory response;positive regulation of macromolecule metabolic process;immune response-activating signal transduction;detection of stimulus;taxis;acute-phase response;positive regulation of leukocyte activation;negative regulation of multicellular organismal process;response to stimulus;innate immune response-activating signal transduction;regulation of multi-organism process;activation of innate immune response;regulation of immune effector process;respiratory burst;regulation of cell motility;positive regulation of leukocyte chemotaxis;positive regulation of cell motility;positive regulation of signal transduction;opsonization;positive regulation of immune effector process;cell activation involved in immune response;positive regulation of response to external stimulus;regulation of response to external stimulus;cell activation;regulation of toll-like receptor 4 signaling pathway;response to wounding;growth involved in symbiotic interaction;cellular biosynthetic process;signaling;cellular response to chemical stimulus;growth of symbiont in host;negative regulation of growth;tumor necrosis factor biosynthetic process;single-organism process;positive regulation of metabolic process;positive regulation of phagocytosis;tumor necrosis factor production;establishment of localization;positive regulation of multicellular organismal process;positive regulation of respiratory burst;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of chemokine production;single-organism transport;regulation of cell activation;granulocyte migration;toll-like receptor signaling pathway;regulation of response to wounding;pattern recognition receptor signaling pathway;positive regulation of response to wounding;regulation of interleukin-8 production;developmental process;locomotion;multicellular organismal process;positive regulation of signaling;positive regulation of cellular component movement;cellular process;cellular response to lipid;positive regulation of membrane invagination;regulation of vesicle-mediated transport;negative regulation of tumor necrosis factor superfamily cytokine production;positive regulation of tumor necrosis factor superfamily cytokine production;regulation of cellular component movement;defense response to other organism;positive regulation of phagocytosis, engulfment;regulation of localization;positive regulation of biosynthetic process;regulation of immune response;positive regulation of toll-like receptor signaling pathway;positive regulation of chemokine production;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;regulation of cytokine production;response to molecule of bacterial origin;regulation of interleukin-6 production;system development;gland development;myeloid leukocyte migration;regulation of response to stress;negative regulation of cytokine production;positive regulation of cytokine production;cellular defense response;cellular response to lipopolysaccharide;cellular response to lipoteichoic acid;positive regulation of cellular biosynthetic process;macrophage activation;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;neutrophil migration;regulation of cellular metabolic process;leukocyte migration;liver development;endocytosis;regulation of phagocytosis;multicellular organism development;regulation of toll-like receptor signaling pathway;regulation of immune system process;growth;positive regulation of neutrophil chemotaxis;regulation of neutrophil chemotaxis;response to lipid;regulation of growth;lipopolysaccharide transport;positive regulation of macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;tumor necrosis factor superfamily cytokine production;respiratory burst involved in inflammatory response;organic substance transport;regulation of granulocyte chemotaxis;regulation of membrane permeability;granulocyte chemotaxis;regulation of leukocyte activation;positive regulation of granulocyte chemotaxis;positive regulation of cell migration;regulation of cell migration;positive regulation of innate immune response;regulation of innate immune response;interleukin-6 production;innate immune response;interleukin-8 production;regulation of neutrophil migration;phagocytosis, engulfment;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of signal transduction;response to chemical;regulation of endocytosis;localization;single-organism localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;toll-like receptor 4 signaling pathway;regulation of locomotion;positive regulation of locomotion;membrane invagination;anatomical structure development;defense response to Gram-positive bacterium;cellular metabolic process;response to lipoteichoic acid;regulation of tumor necrosis factor production;activation of immune response;immune effector process;symbiosis, encompassing mutualism through parasitism;positive regulation of endocytosis;positive regulation of interleukin-8 production;positive regulation of interleukin-6 production;positive regulation of cellular process; 4;3;4;4;3;4;3;3;4;4;4;4;5;5;5;5;5;3;5;4;6;6;4;5;4;3;4;2;2;2;5;5;6;4;5;6;4;3;4;5;4;4;6;4;3;4;4;4;3;3;3;3;3;3;4;6;5;4;2;4;5;5;5;4;3;4;4;4;4;5;5;4;3;4;4;2;3;5;3;4;5;5;6;5;5;2;5;5;4;4;5;5;4;3;4;3;4;2;2;5;4;5;4;5;5;5;4;6;5;4;4;4;3;3;4;4;3;3;1;5;3;6;4;4;4;4;3;3;7;4;3;2;5;3;4;4;4;4;5;4;4;4;4;4;4;4;4;6;4;3;4;2;4;5;3;6;2;3;5;6;3;3;4;5;5;5;4;4;5;7;5;6;4;5;2;2;2;3;4;2;6;5;4;5;5;4;4;6;3;4;4;4;5;4;4;3;4;5;5;4;4;4;4;4;4;5;6;6;5;5;5;4;6;4;3;5;6;6;4;5;3;2;6;6;5;3;6;5;3;5;5;5;5;6;4;5;4;6;5;5;5;5;5;4;5;5;6;3;3;5;3;4;3;5;2;3;4;5;8;3;3;5;3;6;3;5;6;3;3;4;4;5;5;3; GO:0031982;GO:0043230;GO:0044421;GO:0005615;GO:0009986;GO:0043227;GO:0044464;GO:0005623;GO:0005575;GO:0043226;GO:0016020;GO:1903561;GO:0070062;GO:0005576; vesicle;extracellular organelle;extracellular region part;extracellular space;cell surface;membrane-bounded organelle;cell part;cell;cellular_component;organelle;membrane;extracellular vesicle;extracellular exosome;extracellular region; 4;3;2;3;3;3;2;2;1;2;2;3;4;2; GO:0097367;GO:0005488;GO:0005102;GO:0070891;GO:0001530;GO:0008289;GO:0005515;GO:0003674; carbohydrate derivative binding;binding;receptor binding;lipoteichoic acid binding;lipopolysaccharide binding;lipid binding;protein binding;molecular_function; 3;2;4;4;4;3;3;1; K05399 map04064;map04620;map05132;map05152; NF-kappa B signaling pathway;Toll-like receptor signaling pathway;Salmonella infection;Tuberculosis; IPR017954;IPR030675;IPR017943;IPR017942;IPR001124;IPR030180;IPR032942; Lipid-binding serum glycoprotein, conserved site;Lipid binding protein BPI/LBP;Bactericidal permeability-increasing protein, alpha/beta domain;Lipid-binding serum glycoprotein, N-terminal;Lipid-binding serum glycoprotein, C-terminal;Lipopolysaccharide-binding protein;BPI/LBP/Plunc family; extracellular Hs11345448 977.0 V [V] Defense mechanisms; P15814 Immunoglobulin lambda-like polypeptide 1 OS=Homo sapiens OX=9606 GN=IGLL1 PE=1 SV=1 - [IGLL1_HUMAN] 1.017 1.054 0.879 1.027 0.997 1.093 0.964895636 0.467327667 1.030090271 0.591159667 0.833965844 0.453342788 1.096288867 0.709522637 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0051716;GO:0043207;GO:0009617;GO:0048518;GO:0065007;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0050789;GO:0002764;GO:0002768;GO:0016043;GO:0002684;GO:0002682;GO:0006810;GO:0044710;GO:0050794;GO:0006952;GO:0006950;GO:0051249;GO:0008150;GO:0006955;GO:0006958;GO:0051234;GO:0002757;GO:0006897;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0006956;GO:0008152;GO:0023052;GO:0044699;GO:0016064;GO:0008037;GO:0009987;GO:0050871;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0042742;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0006959;GO:0072376;GO:0002443;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;cellular response to stimulus;response to external biotic stimulus;response to bacterium;positive regulation of biological process;biological regulation;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;immune response-regulating cell surface receptor signaling pathway;cellular component organization;positive regulation of immune system process;regulation of immune system process;transport;single-organism metabolic process;regulation of cellular process;defense response;response to stress;regulation of lymphocyte activation;biological_process;immune response;complement activation, classical pathway;establishment of localization;immune response-activating signal transduction;endocytosis;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;metabolic process;signaling;single-organism process;immunoglobulin mediated immune response;cell recognition;cellular process;positive regulation of B cell activation;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;defense response to bacterium;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;humoral immune response;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;4;2;2;6;4;3;3;2;3;5;5;3;4;2;3;2;5;6;3;3;3;4;3;3;4;3;5;1;3;5;3;4;6;2;4;4;4;4;2;2;2;7;4;2;6;4;4;5;5;4;5;4;5;4;6;4;5;4;3;4;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;3; GO:0031982;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0043227;GO:0016020;GO:0005623;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;membrane-bounded organelle;membrane;cell;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;3;3;2;2;4;3;2;2;3;4;3;3;2;3;3;3;2;3;3;4;2;1;2;3; GO:0003674;GO:0005488;GO:0034987;GO:0003823;GO:0005515;GO:0005102; molecular_function;binding;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding; 1;2;5;3;3;4; K06554 IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; cytosol, nucleus P53396 ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3 - [ACLY_HUMAN] 0.527 0.67 1.129 0.788 1.499 0.668 0.786567164 0.666718513 0.525683789 0.442236404 1.685074627 0.437880168 0.44563042 0.471814511 GO:0019222;GO:0044281;GO:0044283;GO:0072350;GO:1901362;GO:1901360;GO:0044710;GO:0044711;GO:0048518;GO:0006112;GO:0032787;GO:1902653;GO:1902652;GO:0043436;GO:0046486;GO:0055114;GO:0043648;GO:0016053;GO:0050789;GO:0019432;GO:0071616;GO:0009893;GO:0006629;GO:1901576;GO:0051186;GO:0051188;GO:0065007;GO:0006101;GO:0035383;GO:0035384;GO:0050794;GO:0008150;GO:0008152;GO:0015980;GO:0044272;GO:0046394;GO:0006695;GO:0006694;GO:0044763;GO:1901617;GO:1901615;GO:0006633;GO:0006631;GO:0006637;GO:0006732;GO:0006639;GO:0006638;GO:0044249;GO:0035338;GO:0035336;GO:0035337;GO:0044699;GO:0046463;GO:0046460;GO:0016126;GO:0016125;GO:0006641;GO:0046165;GO:0009987;GO:0044255;GO:0008202;GO:0008203;GO:0006084;GO:0006085;GO:0006082;GO:0031325;GO:0031323;GO:0019752;GO:0009108;GO:0006091;GO:0006066;GO:0006107;GO:0072330;GO:0071704;GO:0045017;GO:0009058;GO:0046949;GO:0008610;GO:0044238;GO:0044237;GO:0006790;GO:0006793;GO:0048522; regulation of metabolic process;small molecule metabolic process;small molecule biosynthetic process;tricarboxylic acid metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;positive regulation of biological process;energy reserve metabolic process;monocarboxylic acid metabolic process;secondary alcohol biosynthetic process;secondary alcohol metabolic process;oxoacid metabolic process;glycerolipid metabolic process;oxidation-reduction process;dicarboxylic acid metabolic process;organic acid biosynthetic process;regulation of biological process;triglyceride biosynthetic process;acyl-CoA biosynthetic process;positive regulation of metabolic process;lipid metabolic process;organic substance biosynthetic process;cofactor metabolic process;cofactor biosynthetic process;biological regulation;citrate metabolic process;thioester metabolic process;thioester biosynthetic process;regulation of cellular process;biological_process;metabolic process;energy derivation by oxidation of organic compounds;sulfur compound biosynthetic process;carboxylic acid biosynthetic process;cholesterol biosynthetic process;steroid biosynthetic process;single-organism cellular process;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;acyl-CoA metabolic process;coenzyme metabolic process;acylglycerol metabolic process;neutral lipid metabolic process;cellular biosynthetic process;long-chain fatty-acyl-CoA biosynthetic process;long-chain fatty-acyl-CoA metabolic process;fatty-acyl-CoA metabolic process;single-organism process;acylglycerol biosynthetic process;neutral lipid biosynthetic process;sterol biosynthetic process;sterol metabolic process;triglyceride metabolic process;alcohol biosynthetic process;cellular process;cellular lipid metabolic process;steroid metabolic process;cholesterol metabolic process;acetyl-CoA metabolic process;acetyl-CoA biosynthetic process;organic acid metabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;coenzyme biosynthetic process;generation of precursor metabolites and energy;alcohol metabolic process;oxaloacetate metabolic process;monocarboxylic acid biosynthetic process;organic substance metabolic process;glycerolipid biosynthetic process;biosynthetic process;fatty-acyl-CoA biosynthetic process;lipid biosynthetic process;primary metabolic process;cellular metabolic process;sulfur compound metabolic process;phosphorus metabolic process;positive regulation of cellular process; 3;4;5;7;5;4;3;4;2;5;7;7;6;5;5;4;7;5;2;7;6;3;4;4;4;5;2;8;4;5;3;1;2;4;5;6;8;6;3;5;4;6;5;5;5;6;5;4;8;7;6;2;6;5;7;6;7;6;2;4;5;7;6;7;4;4;4;6;6;4;5;8;7;3;5;3;7;5;3;3;4;4;3; GO:0031974;GO:0031982;GO:0031981;GO:0016020;GO:0043230;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0005886;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;vesicle;nuclear lumen;membrane;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;cell part;cell;intracellular;cell periphery;extracellular exosome;plasma membrane;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;5;2;3;4;3;5;4;3;2;2;3;3;2;5;3;4;4;5;2;2;3;3;4;3;3;1;4;2; GO:1901363;GO:0000166;GO:0035639;GO:0016740;GO:0016746;GO:0046872;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0046912;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0003824;GO:0097159;GO:0032555;GO:0032553;GO:0043169;GO:0043167;GO:0048037;GO:0030554;GO:0003878;GO:0001883;GO:0001882;GO:0032559;GO:0036094;GO:0032550; heterocyclic compound binding;nucleotide binding;purine ribonucleoside triphosphate binding;transferase activity;transferase activity, transferring acyl groups;metal ion binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;catalytic activity;organic cyclic compound binding;purine ribonucleotide binding;ribonucleotide binding;cation binding;ion binding;cofactor binding;adenyl nucleotide binding;ATP citrate synthase activity;purine nucleoside binding;nucleoside binding;adenyl ribonucleotide binding;small molecule binding;purine ribonucleoside binding; 3;4;5;3;4;5;3;1;2;4;5;5;5;6;4;2;3;5;4;4;3;3;6;6;5;4;6;3;6; K01648 map00020;map00720;map01100;map01110;map01120;map01130; Citrate cycle (TCA cycle);Carbon fixation pathways in prokaryotes;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics; IPR002020;IPR033847;IPR003781;IPR016143;IPR032263;IPR017866;IPR005811;IPR017440;IPR016142;IPR014608;IPR016102;IPR016040; Citrate synthase;ATP-citrate lyase/succinyl-CoA ligase, conserved site;CoA-binding;Citrate synthase-like, small alpha subdomain;ATP-citrate synthase, citrate-binding domain;Succinyl-CoA synthetase, beta subunit, conserved site;ATP-citrate lyase/succinyl-CoA ligase;ATP-citrate lyase/succinyl-CoA ligase, active site;Citrate synthase-like, large alpha subdomain;ATP-citrate synthase;Succinyl-CoA synthetase-like;NAD(P)-binding domain; cytosol Hs4501865 2218.0 C [C] Energy production and conversion; Q9UIF3 Tektin-2 OS=Homo sapiens OX=9606 GN=TEKT2 PE=1 SV=1 - [TEKT2_HUMAN] 0.918 0.856 0.94 1.294 1.161 1.327 1.072429907 nan 1.114556417 nan 1.098130841 nan 1.142980189 nan GO:0022607;GO:0070271;GO:0043933;GO:0030031;GO:0010927;GO:0000226;GO:0034622;GO:0009653;GO:0044699;GO:0070925;GO:0000902;GO:0071822;GO:0048869;GO:0048858;GO:0006928;GO:0070286;GO:0016043;GO:0032989;GO:0065003;GO:0030030;GO:0071840;GO:0048646;GO:0032502;GO:0042384;GO:0060271;GO:0030317;GO:0009987;GO:0036159;GO:0051674;GO:0044767;GO:0008150;GO:0040011;GO:0043623;GO:0051179;GO:0032990;GO:0006996;GO:0006461;GO:0007017;GO:0007010;GO:0048870;GO:0001578;GO:0048856;GO:0035082;GO:1902589;GO:0044085;GO:0044763;GO:0044782; cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;cell projection assembly;cellular component assembly involved in morphogenesis;microtubule cytoskeleton organization;cellular macromolecular complex assembly;anatomical structure morphogenesis;single-organism process;organelle assembly;cell morphogenesis;protein complex subunit organization;cellular developmental process;cell projection morphogenesis;movement of cell or subcellular component;axonemal dynein complex assembly;cellular component organization;cellular component morphogenesis;macromolecular complex assembly;cell projection organization;cellular component organization or biogenesis;anatomical structure formation involved in morphogenesis;developmental process;cilium assembly;cilium morphogenesis;sperm motility;cellular process;inner dynein arm assembly;localization of cell;single-organism developmental process;biological_process;locomotion;cellular protein complex assembly;localization;cell part morphogenesis;organelle organization;protein complex assembly;microtubule-based process;cytoskeleton organization;cell motility;microtubule bundle formation;anatomical structure development;axoneme assembly;single-organism organelle organization;cellular component biogenesis;single-organism cellular process;cilium organization; 4;4;4;5;4;5;6;3;2;5;5;5;4;5;4;5;3;4;5;4;2;3;2;5;6;4;2;6;3;3;1;2;6;2;5;4;5;4;5;3;6;3;5;4;3;3;5; GO:0099512;GO:0099513;GO:0005929;GO:0043229;GO:0015630;GO:0005874;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0031514;GO:0005634;GO:0044430;GO:0005856;GO:0042995;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;cilium;intracellular organelle;microtubule cytoskeleton;microtubule;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;motile cilium;nucleus;cytoskeletal part;cytoskeleton;cell projection;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part;organelle part; 2;3;3;3;6;4;3;3;2;4;3;4;5;4;5;3;4;4;2;2;3;1;3;2; K18629 IPR000435; Tektin; cytosol Hs16507950 871.0 Z [Z] Cytoskeleton; P49913 Cathelicidin antimicrobial peptide OS=Homo sapiens OX=9606 GN=CAMP PE=1 SV=1 - [CAMP_HUMAN] 1.096 1.114 1.159 1.093 0.757 0.84 0.983842011 nan 1.443857332 nan 1.040394973 nan 1.109643329 nan GO:0008104;GO:0019732;GO:0019730;GO:0019731;GO:0051049;GO:0051702;GO:0002385;GO:0043207;GO:0051047;GO:0044419;GO:0051817;GO:0048518;GO:0048519;GO:0001906;GO:0044144;GO:0019725;GO:0051050;GO:2000482;GO:2000484;GO:0050832;GO:0051818;GO:0050830;GO:0009607;GO:0044140;GO:0051707;GO:0044146;GO:0051704;GO:0044707;GO:0009605;GO:0002376;GO:0002227;GO:0032940;GO:0042742;GO:0044139;GO:0050829;GO:0051222;GO:0051223;GO:0044133;GO:0050708;GO:0050707;GO:0065007;GO:0051873;GO:0065008;GO:0070201;GO:0009306;GO:0006810;GO:0050794;GO:0006952;GO:0043903;GO:0043900;GO:0043901;GO:0008150;GO:0051239;GO:0006955;GO:0006959;GO:0046903;GO:0050715;GO:0050714;GO:0050896;GO:0031640;GO:0006950;GO:0001878;GO:0051046;GO:0009617;GO:0006954;GO:0044110;GO:1903530;GO:0044116;GO:1903532;GO:1904951;GO:0044699;GO:0032880;GO:0051234;GO:0044364;GO:0051240;GO:0051852;GO:0051851;GO:0051641;GO:0032677;GO:0032501;GO:0009987;GO:0098542;GO:0045454;GO:0032879;GO:0033036;GO:0002544;GO:0001816;GO:0001817;GO:0001819;GO:0045926;GO:0060341;GO:0072606;GO:0042592;GO:0050663;GO:0040007;GO:0040008;GO:0050789;GO:0071702;GO:0045087;GO:0032637;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0045184;GO:0051883;GO:0009620;GO:0002251;GO:0015031;GO:0044403;GO:0032757;GO:0035821;GO:0048522; protein localization;antifungal humoral response;antimicrobial humoral response;antibacterial humoral response;regulation of transport;interaction with symbiont;mucosal immune response;response to external biotic stimulus;positive regulation of secretion;interspecies interaction between organisms;modification of morphology or physiology of other organism involved in symbiotic interaction;positive regulation of biological process;negative regulation of biological process;cell killing;modulation of growth of symbiont involved in interaction with host;cellular homeostasis;positive regulation of transport;regulation of interleukin-8 secretion;positive regulation of interleukin-8 secretion;defense response to fungus;disruption of cells of other organism involved in symbiotic interaction;defense response to Gram-positive bacterium;response to biotic stimulus;negative regulation of growth of symbiont on or near host surface;response to other organism;negative regulation of growth of symbiont involved in interaction with host;multi-organism process;single-multicellular organism process;response to external stimulus;immune system process;innate immune response in mucosa;secretion by cell;defense response to bacterium;modulation of growth of symbiont on or near host;defense response to Gram-negative bacterium;positive regulation of protein transport;regulation of protein transport;growth of symbiont on or near host;regulation of protein secretion;regulation of cytokine secretion;biological regulation;killing by host of symbiont cells;regulation of biological quality;regulation of establishment of protein localization;protein secretion;transport;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;regulation of multi-organism process;negative regulation of multi-organism process;biological_process;regulation of multicellular organismal process;immune response;humoral immune response;secretion;positive regulation of cytokine secretion;positive regulation of protein secretion;response to stimulus;killing of cells of other organism;response to stress;response to yeast;regulation of secretion;response to bacterium;inflammatory response;growth involved in symbiotic interaction;regulation of secretion by cell;growth of symbiont involved in interaction with host;positive regulation of secretion by cell;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;establishment of localization;disruption of cells of other organism;positive regulation of multicellular organismal process;disruption by host of symbiont cells;modification by host of symbiont morphology or physiology;cellular localization;regulation of interleukin-8 production;multicellular organismal process;cellular process;defense response to other organism;cell redox homeostasis;regulation of localization;macromolecule localization;chronic inflammatory response;cytokine production;regulation of cytokine production;positive regulation of cytokine production;negative regulation of growth;regulation of cellular localization;interleukin-8 secretion;homeostatic process;cytokine secretion;growth;regulation of growth;regulation of biological process;organic substance transport;innate immune response;interleukin-8 production;single-organism transport;single-organism cellular process;localization;single-organism localization;establishment of protein localization;killing of cells in other organism involved in symbiotic interaction;response to fungus;organ or tissue specific immune response;protein transport;symbiosis, encompassing mutualism through parasitism;positive regulation of interleukin-8 production;modification of morphology or physiology of other organism;positive regulation of cellular process; 4;5;4;5;4;4;5;4;4;3;4;2;2;2;4;4;3;6;6;5;5;6;3;5;3;4;2;3;3;2;5;4;5;5;6;4;5;5;6;5;2;5;3;5;5;4;3;4;4;3;3;1;3;3;4;5;5;5;2;3;3;5;5;4;5;3;5;4;4;3;2;4;3;4;3;5;5;3;5;2;2;4;4;3;3;6;4;4;4;3;4;6;4;5;2;3;2;5;4;5;4;3;2;3;4;4;4;4;5;4;5;3;3; GO:0031982;GO:0016023;GO:0005615;GO:0031988;GO:0099503;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0043227;GO:0030141;GO:0012505;GO:0044444;GO:0097708;GO:0005737;GO:0031410;GO:0030312;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005618;GO:0043229;GO:0042581;GO:1903561;GO:0070062;GO:0005575;GO:0005576;GO:0043226; vesicle;cytoplasmic, membrane-bounded vesicle;extracellular space;membrane-bounded vesicle;secretory vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;membrane-bounded organelle;secretory granule;endomembrane system;cytoplasmic part;intracellular vesicle;cytoplasm;cytoplasmic vesicle;external encapsulating structure;cell part;cell;intracellular;cell periphery;cell wall;intracellular organelle;specific granule;extracellular vesicle;extracellular exosome;cellular_component;extracellular region;organelle; 4;5;3;5;6;3;4;3;2;3;4;3;4;4;4;5;3;2;2;3;3;4;3;5;3;4;1;2;2; K13916 map04970;map05152; Salivary secretion;Tuberculosis; IPR018216;IPR001894;IPR022746; Cathelicidin, conserved site;Cathelicidin;Cathelicidin, antimicrobial peptide, C-terminal; extracellular Q8IZ41 Ras and EF-hand domain-containing protein OS=Homo sapiens OX=9606 GN=RASEF PE=1 SV=1 - [RASEF_HUMAN] 0.969 1.399 0.661 1.136 1.254 0.607 0.692637598 nan 0.905901116 nan 0.472480343 nan 0.484051037 nan GO:0008104;GO:0023052;GO:0007165;GO:0035556;GO:0050789;GO:0044699;GO:0051716;GO:0007264;GO:0065007;GO:0071702;GO:0033036;GO:0006810;GO:0009987;GO:0050794;GO:0045184;GO:0015031;GO:0008150;GO:0007154;GO:0051234;GO:0051179;GO:0044700;GO:0050896;GO:0044763; protein localization;signaling;signal transduction;intracellular signal transduction;regulation of biological process;single-organism process;cellular response to stimulus;small GTPase mediated signal transduction;biological regulation;organic substance transport;macromolecule localization;transport;cellular process;regulation of cellular process;establishment of protein localization;protein transport;biological_process;cell communication;establishment of localization;localization;single organism signaling;response to stimulus;single-organism cellular process; 4;2;4;5;2;2;3;6;2;5;3;4;2;3;4;5;1;4;3;2;3;2;3; GO:0005737;GO:0048471;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; cytoplasm;perinuclear region of cytoplasm;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 4;5;2;2;3;1;4;3; GO:0003674;GO:0035639;GO:1901363;GO:0001883;GO:0000166;GO:0001882;GO:0043169;GO:0032549;GO:0036094;GO:0043167;GO:0032555;GO:0032561;GO:0005509;GO:0017076;GO:0005525;GO:0043168;GO:1901265;GO:0046872;GO:0097367;GO:0097159;GO:0019001;GO:0032550;GO:0032553;GO:0005488; molecular_function;purine ribonucleoside triphosphate binding;heterocyclic compound binding;purine nucleoside binding;nucleotide binding;nucleoside binding;cation binding;ribonucleoside binding;small molecule binding;ion binding;purine ribonucleotide binding;guanyl ribonucleotide binding;calcium ion binding;purine nucleotide binding;GTP binding;anion binding;nucleoside phosphate binding;metal ion binding;carbohydrate derivative binding;organic cyclic compound binding;guanyl nucleotide binding;purine ribonucleoside binding;ribonucleotide binding;binding; 1;5;3;5;4;4;4;5;3;3;5;6;6;5;6;4;4;5;3;3;6;6;4;2; K17199 IPR018247;IPR001806;IPR011992;IPR005225;IPR002048;IPR027417; EF-Hand 1, calcium-binding site;Small GTPase superfamily;EF-hand domain pair;Small GTP-binding protein domain;EF-hand domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs18572474 184.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q5T1R4 Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=2 SV=1 - [ZEP3_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0007517;GO:0010604;GO:0048869;GO:0007519;GO:0048513;GO:0048518;GO:0044700;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0019438;GO:0007165;GO:0051716;GO:0009893;GO:0009891;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0035914;GO:0018130;GO:0009889;GO:0009888;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0061061;GO:0044699;GO:0006139;GO:1903508;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0048731;GO:0032502;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0014706;GO:0007275;GO:2000112;GO:0071704;GO:0010467;GO:0010468;GO:0045935;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0007154;GO:0044238;GO:0048856;GO:0044237;GO:0060537;GO:0060538;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;muscle organ development;positive regulation of macromolecule metabolic process;cellular developmental process;skeletal muscle tissue development;animal organ development;positive regulation of biological process;single organism signaling;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;signal transduction;cellular response to stimulus;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;skeletal muscle cell differentiation;heterocycle biosynthetic process;regulation of biosynthetic process;tissue development;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;muscle structure development;single-organism process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;system development;developmental process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;striated muscle tissue development;multicellular organism development;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;primary metabolic process;anatomical structure development;cellular metabolic process;muscle tissue development;skeletal muscle organ development;positive regulation of cellular process; 4;3;5;4;5;4;4;7;4;2;3;4;6;4;3;5;4;3;3;4;3;2;7;4;4;2;7;6;5;4;4;3;1;2;5;5;5;2;6;5;5;6;6;5;4;4;2;5;4;2;4;7;2;2;4;7;6;5;5;4;6;5;4;2;5;5;4;4;5;6;4;6;3;5;5;5;5;3;3;5;3;4;4;4;3;3;3;5;6;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasm;nucleus;cell part;cell;organelle;cellular_component; 4;3;3;3;3;4;5;2;2;2;1; GO:0043169;GO:0001071;GO:1901363;GO:0046872;GO:0001067;GO:0044212;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043565;GO:0097159;GO:0000975;GO:0043167;GO:0003700; cation binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;metal ion binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;sequence-specific DNA binding;organic cyclic compound binding;regulatory region DNA binding;ion binding;transcription factor activity, sequence-specific DNA binding; 4;2;3;5;5;7;1;2;4;5;6;3;6;3;3; K09239 IPR013087;IPR034729; Zinc finger C2H2-type;Zinc finger CCHC HIVEP-type; nucleus Hs13375634 4721.0 R [R] General function prediction only; P20851 C4b-binding protein beta chain OS=Homo sapiens OX=9606 GN=C4BPB PE=1 SV=1 - [C4BPB_HUMAN] 1.047 0.956 1.038 1.09 1.034 0.934 1.095188285 0.083243768 1.054158607 0.780728167 1.085774059 0.097646569 0.903288201 0.947380893 GO:0007599;GO:0080090;GO:0019222;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0002707;GO:0002706;GO:0002704;GO:0002703;GO:0006909;GO:0002455;GO:0071840;GO:0044710;GO:0010605;GO:0010604;GO:0050727;GO:0048518;GO:0065007;GO:0002683;GO:0019724;GO:0007596;GO:0060255;GO:0002822;GO:0002823;GO:2000257;GO:0032268;GO:0030162;GO:0030163;GO:0002673;GO:0051128;GO:0016192;GO:0009605;GO:0044707;GO:0019538;GO:0002820;GO:0002376;GO:0009896;GO:0009894;GO:0030449;GO:0009893;GO:0002923;GO:0010629;GO:0002920;GO:0002924;GO:0050789;GO:0044267;GO:1901575;GO:0044260;GO:0016043;GO:0002684;GO:0002682;GO:0031347;GO:0065008;GO:0045916;GO:0006810;GO:0051248;GO:0042060;GO:0050794;GO:0006952;GO:0002889;GO:0006950;GO:0050817;GO:0006956;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0008228;GO:0045732;GO:0002697;GO:1903318;GO:0008150;GO:1903317;GO:0002698;GO:0008152;GO:0032101;GO:0002819;GO:0009611;GO:0042176;GO:0009892;GO:0044699;GO:0002890;GO:0050764;GO:0051234;GO:0030100;GO:0051246;GO:0051247;GO:0051179;GO:0006508;GO:1903034;GO:0032501;GO:0050878;GO:0009987;GO:0060627;GO:0002712;GO:0002921;GO:0048519;GO:0016485;GO:0032879;GO:0050777;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:1903027;GO:0045861;GO:0080134;GO:2000258;GO:0031324;GO:0031323;GO:0010955;GO:0032269;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045959;GO:0045087;GO:0002449;GO:0044765;GO:0002713;GO:0016064;GO:0030450;GO:0002443;GO:0009056;GO:0009057;GO:1902578;GO:0044238;GO:0044237;GO:0002250;GO:0002253;GO:0002252;GO:0048523; hemostasis;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;negative regulation of lymphocyte mediated immunity;regulation of lymphocyte mediated immunity;negative regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;phagocytosis;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;negative regulation of immune system process;B cell mediated immunity;blood coagulation;regulation of macromolecule metabolic process;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of protein activation cascade;regulation of cellular protein metabolic process;regulation of proteolysis;protein catabolic process;regulation of acute inflammatory response;regulation of cellular component organization;vesicle-mediated transport;response to external stimulus;single-multicellular organism process;protein metabolic process;negative regulation of adaptive immune response;immune system process;positive regulation of catabolic process;regulation of catabolic process;regulation of complement activation;positive regulation of metabolic process;regulation of humoral immune response mediated by circulating immunoglobulin;negative regulation of gene expression;regulation of humoral immune response;negative regulation of humoral immune response mediated by circulating immunoglobulin;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;cellular component organization;positive regulation of immune system process;regulation of immune system process;regulation of defense response;regulation of biological quality;negative regulation of complement activation;transport;negative regulation of protein metabolic process;wound healing;regulation of cellular process;defense response;regulation of immunoglobulin mediated immune response;response to stress;coagulation;complement activation;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;endocytosis;protein maturation;response to stimulus;opsonization;positive regulation of protein catabolic process;regulation of immune effector process;negative regulation of protein maturation;biological_process;regulation of protein maturation;negative regulation of immune effector process;metabolic process;regulation of response to external stimulus;regulation of adaptive immune response;response to wounding;regulation of protein catabolic process;negative regulation of metabolic process;single-organism process;negative regulation of immunoglobulin mediated immune response;regulation of phagocytosis;establishment of localization;regulation of endocytosis;regulation of protein metabolic process;positive regulation of protein metabolic process;localization;proteolysis;regulation of response to wounding;multicellular organismal process;regulation of body fluid levels;cellular process;regulation of vesicle-mediated transport;regulation of B cell mediated immunity;negative regulation of humoral immune response;negative regulation of biological process;protein processing;regulation of localization;negative regulation of immune response;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of opsonization;negative regulation of proteolysis;regulation of response to stress;negative regulation of protein activation cascade;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of protein processing;negative regulation of cellular protein metabolic process;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;negative regulation of complement activation, classical pathway;innate immune response;lymphocyte mediated immunity;single-organism transport;negative regulation of B cell mediated immunity;immunoglobulin mediated immune response;regulation of complement activation, classical pathway;leukocyte mediated immunity;catabolic process;macromolecule catabolic process;single-organism localization;primary metabolic process;cellular metabolic process;adaptive immune response;activation of immune response;immune effector process;negative regulation of cellular process; 5;4;3;4;3;3;3;6;6;5;5;5;5;2;3;4;4;5;2;2;3;6;5;4;6;6;4;5;6;5;6;4;5;3;3;4;5;2;4;4;5;3;6;5;5;6;2;5;4;4;3;3;3;5;3;5;4;5;5;3;4;8;3;4;4;5;3;6;5;4;7;6;5;2;4;5;4;6;1;6;4;2;4;5;4;5;3;2;8;6;3;5;5;5;2;5;5;2;4;2;4;7;5;2;6;3;4;4;5;4;4;5;6;4;4;4;4;7;5;3;3;5;5;6;4;5;4;7;7;6;4;3;5;3;3;3;4;3;3;3; GO:0016020;GO:0044217;GO:0044421;GO:0044215;GO:0044464;GO:0005623;GO:0071944;GO:0044216;GO:0005615;GO:0005886;GO:0005575;GO:0005576; membrane;other organism part;extracellular region part;other organism;cell part;cell;cell periphery;other organism cell;extracellular space;plasma membrane;cellular_component;extracellular region; 2;2;2;2;2;2;3;3;3;3;1;2; K04003 map04610;map05133; Complement and coagulation cascades;Pertussis; IPR000436; Sushi/SCR/CCP domain; extracellular Hs4502505 526.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; P0C0L4 Complement C4-A OS=Homo sapiens OX=9606 GN=C4A PE=1 SV=2 - [CO4A_HUMAN] 1.042 1.033 0.89 1.09 1.073 0.949 1.008712488 0.558216971 1.01584343 0.970840312 0.861568248 0.125326637 0.88443616 0.804685044 GO:0006909;GO:0080090;GO:0019222;GO:0051049;GO:0048584;GO:0048583;GO:0016043;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:2000425;GO:0019724;GO:0051050;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0051128;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0002684;GO:0002682;GO:0071840;GO:0045087;GO:0051130;GO:0006810;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0002697;GO:0006956;GO:1903317;GO:0006954;GO:0032101;GO:0009611;GO:0043277;GO:0044699;GO:0050766;GO:0050764;GO:0051234;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0060627;GO:2000427;GO:0016485;GO:0032879;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0002443;GO:0071704;GO:0010467;GO:0010468;GO:0002449;GO:0044765;GO:0030100;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0045807;GO:0048522; phagocytosis;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;cellular component organization;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;regulation of apoptotic cell clearance;B cell mediated immunity;positive regulation of transport;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;regulation of cellular component organization;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;positive regulation of immune system process;regulation of immune system process;cellular component organization or biogenesis;innate immune response;positive regulation of cellular component organization;transport;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;endocytosis;protein maturation;response to stimulus;regulation of immune effector process;complement activation;regulation of protein maturation;inflammatory response;regulation of response to external stimulus;response to wounding;apoptotic cell clearance;single-organism process;positive regulation of phagocytosis;regulation of phagocytosis;establishment of localization;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;regulation of vesicle-mediated transport;positive regulation of apoptotic cell clearance;protein processing;regulation of localization;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;gene expression;regulation of gene expression;lymphocyte mediated immunity;single-organism transport;regulation of endocytosis;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of endocytosis;positive regulation of cellular process; 5;4;3;4;3;3;3;5;5;3;5;2;2;7;6;3;4;4;6;6;4;5;3;4;2;5;5;2;3;3;2;4;4;4;3;4;3;7;1;2;3;6;5;4;7;6;5;2;4;4;6;5;4;4;6;2;5;6;3;5;5;5;2;4;6;6;3;4;5;4;4;4;3;4;3;5;5;5;4;5;2;3;3;4;3;3;4;3; GO:0031982;GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0072562;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;blood microparticle;cell part;cell;cell periphery;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;2;3;2;3;3;2;2;3;4;2;3;3;3;1;2; GO:0098772;GO:0004866;GO:0061135;GO:0003674;GO:0005488;GO:0001849;GO:0001848;GO:0001846;GO:0004857;GO:0030414;GO:0005515;GO:0030234;GO:0061134; molecular function regulator;endopeptidase inhibitor activity;endopeptidase regulator activity;molecular_function;binding;complement component C1q binding;complement binding;opsonin binding;enzyme inhibitor activity;peptidase inhibitor activity;protein binding;enzyme regulator activity;peptidase regulator activity; 2;6;5;1;2;5;4;4;4;5;3;3;4; K03989 map04610;map05133;map05150;map05322; Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus; IPR011626;IPR013783;IPR009048;IPR000020;IPR008993;IPR018933;IPR019742;IPR001134;IPR001599;IPR011625;IPR008930;IPR002890;IPR018081;IPR001840;IPR019565; Alpha-macroglobulin complement component;Immunoglobulin-like fold;Alpha-macroglobulin, receptor-binding;Anaphylatoxin/fibulin;Tissue inhibitor of metalloproteinases-like, OB-fold;Netrin module, non-TIMP type;Alpha-2-macroglobulin, conserved site;Netrin domain;Alpha-2-macroglobulin;Alpha-2-macroglobulin, N-terminal 2;Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;Alpha-2-macroglobulin, N-terminal;Anaphylatoxin, complement system;Anaphylatoxin, complement system domain;Alpha-2-macroglobulin, thiol-ester bond-forming; extracellular Hs14577919 3592.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9Y5H6 Protocadherin alpha-8 OS=Homo sapiens OX=9606 GN=PCDHA8 PE=2 SV=1 - [PCDA8_HUMAN] 1.075 1.042 0.737 1.252 1.017 1.585 1.031669866 nan 1.23107178 nan 0.707293666 nan 1.558505408 nan GO:0007275;GO:0044699;GO:0032502;GO:0032501;GO:0098609;GO:0044767;GO:0008150;GO:0007155;GO:0007156;GO:0098742;GO:0022610;GO:0007399;GO:0044707;GO:0048856;GO:0048731; multicellular organism development;single-organism process;developmental process;multicellular organismal process;cell-cell adhesion;single-organism developmental process;biological_process;cell adhesion;homophilic cell adhesion via plasma membrane adhesion molecules;cell-cell adhesion via plasma-membrane adhesion molecules;biological adhesion;nervous system development;single-multicellular organism process;anatomical structure development;system development; 4;2;2;2;4;3;1;3;6;5;2;5;3;3;4; GO:0031224;GO:0071944;GO:0031226;GO:0016021;GO:0016020;GO:0044425;GO:0044459;GO:0005887;GO:0005886;GO:0044464;GO:0005623;GO:0005575; intrinsic component of membrane;cell periphery;intrinsic component of plasma membrane;integral component of membrane;membrane;membrane part;plasma membrane part;integral component of plasma membrane;plasma membrane;cell part;cell;cellular_component; 3;3;4;4;2;2;3;4;3;2;2;1; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding; 1;2;4;3;6;5; K16493 IPR002126;IPR020894;IPR015919;IPR013164;IPR031904; Cadherin;Cadherin conserved site;Cadherin-like;Cadherin, N-terminal;Cadherin, C-terminal catenin-binding domain; extracellular Hs9256596 1946.0 S [S] Function unknown; Q68CL5 Tubulin polyglutamylase complex subunit 2 OS=Homo sapiens OX=9606 GN=TPGS2 PE=2 SV=2 - [TPGS2_HUMAN] 0.84 0.728 1.561 1.216 0.655 1.415 1.153846154 nan 1.85648855 nan 2.144230769 nan 2.160305344 nan GO:0005737;GO:0005856;GO:0015630;GO:0099512;GO:0099513;GO:0043232;GO:0044464;GO:0044446;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0043228;GO:0044430;GO:0044424;GO:0005874;GO:0043226;GO:0044422; cytoplasm;cytoskeleton;microtubule cytoskeleton;supramolecular fiber;polymeric cytoskeletal fiber;intracellular non-membrane-bounded organelle;cell part;intracellular organelle part;cell;intracellular;cellular_component;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;intracellular part;microtubule;organelle;organelle part; 4;5;6;2;3;4;2;3;2;3;1;3;3;4;3;4;2;2; K16605 IPR018958; Knr4/Smi1-like domain; nucleus P04180 Phosphatidylcholine-sterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=1 SV=1 - [LCAT_HUMAN] 0.994 1.004 0.972 1.045 0.995 1.483 0.990039841 0.526139294 1.050251256 0.310560072 0.96812749 0.864022739 1.490452261 0.01644994 GO:0044281;GO:0044283;GO:0071840;GO:0044710;GO:0044711;GO:0034433;GO:0065007;GO:0033036;GO:0034367;GO:0034368;GO:0034369;GO:1902652;GO:0010038;GO:0046486;GO:0051128;GO:0010876;GO:0010033;GO:1901564;GO:0044707;GO:1901566;GO:0019538;GO:0048878;GO:0019637;GO:0034377;GO:0034375;GO:0022607;GO:0034372;GO:0015918;GO:0034370;GO:0006807;GO:0042157;GO:0042158;GO:0050789;GO:1901576;GO:0044260;GO:0097164;GO:0016043;GO:0065003;GO:0097006;GO:0014070;GO:0065005;GO:0065008;GO:0006629;GO:0009308;GO:0090107;GO:0006810;GO:0050794;GO:0042439;GO:0008152;GO:0042632;GO:0006576;GO:0051234;GO:0090407;GO:0008654;GO:0050896;GO:0044765;GO:0008150;GO:1901617;GO:1901615;GO:0051239;GO:0031960;GO:0006869;GO:0030301;GO:0044249;GO:0034641;GO:0051384;GO:0034645;GO:0044699;GO:0009719;GO:0015850;GO:0043691;GO:0006644;GO:0032501;GO:0046165;GO:0009987;GO:0055088;GO:0044106;GO:0044255;GO:0030258;GO:0008202;GO:0008203;GO:0009725;GO:0043170;GO:0046474;GO:0046470;GO:0048545;GO:0010035;GO:0006656;GO:0006650;GO:0043933;GO:0034380;GO:1990267;GO:0042592;GO:0016125;GO:0055092;GO:0071825;GO:0071827;GO:0033993;GO:1901360;GO:0071704;GO:0034434;GO:0034435;GO:0046688;GO:0071702;GO:0045017;GO:0009058;GO:0009059;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0008610;GO:0044238;GO:0044237;GO:0006066;GO:0044087;GO:0006796;GO:0044085;GO:0006793; small molecule metabolic process;small molecule biosynthetic process;cellular component organization or biogenesis;single-organism metabolic process;single-organism biosynthetic process;steroid esterification;biological regulation;macromolecule localization;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;secondary alcohol metabolic process;response to metal ion;glycerolipid metabolic process;regulation of cellular component organization;lipid localization;response to organic substance;organonitrogen compound metabolic process;single-multicellular organism process;organonitrogen compound biosynthetic process;protein metabolic process;chemical homeostasis;organophosphate metabolic process;plasma lipoprotein particle assembly;high-density lipoprotein particle remodeling;cellular component assembly;very-low-density lipoprotein particle remodeling;sterol transport;triglyceride-rich lipoprotein particle remodeling;nitrogen compound metabolic process;lipoprotein metabolic process;lipoprotein biosynthetic process;regulation of biological process;organic substance biosynthetic process;cellular macromolecule metabolic process;ammonium ion metabolic process;cellular component organization;macromolecular complex assembly;regulation of plasma lipoprotein particle levels;response to organic cyclic compound;protein-lipid complex assembly;regulation of biological quality;lipid metabolic process;amine metabolic process;regulation of high-density lipoprotein particle assembly;transport;regulation of cellular process;ethanolamine-containing compound metabolic process;metabolic process;cholesterol homeostasis;cellular biogenic amine metabolic process;establishment of localization;organophosphate biosynthetic process;phospholipid biosynthetic process;response to stimulus;single-organism transport;biological_process;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;regulation of multicellular organismal process;response to corticosteroid;lipid transport;cholesterol transport;cellular biosynthetic process;cellular nitrogen compound metabolic process;response to glucocorticoid;cellular macromolecule biosynthetic process;single-organism process;response to endogenous stimulus;organic hydroxy compound transport;reverse cholesterol transport;phospholipid metabolic process;multicellular organismal process;alcohol biosynthetic process;cellular process;lipid homeostasis;cellular amine metabolic process;cellular lipid metabolic process;lipid modification;steroid metabolic process;cholesterol metabolic process;response to hormone;macromolecule metabolic process;glycerophospholipid biosynthetic process;phosphatidylcholine metabolic process;response to steroid hormone;response to inorganic substance;phosphatidylcholine biosynthetic process;glycerophospholipid metabolic process;macromolecular complex subunit organization;high-density lipoprotein particle assembly;response to transition metal nanoparticle;homeostatic process;sterol metabolic process;sterol homeostasis;protein-lipid complex subunit organization;plasma lipoprotein particle organization;response to lipid;organic cyclic compound metabolic process;organic substance metabolic process;sterol esterification;cholesterol esterification;response to copper ion;organic substance transport;glycerolipid biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;response to chemical;localization;single-organism localization;lipid biosynthetic process;primary metabolic process;cellular metabolic process;alcohol metabolic process;regulation of cellular component biogenesis;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process; 4;5;2;3;4;6;2;3;5;6;4;6;5;5;4;4;4;4;3;5;4;5;4;4;5;4;6;6;5;3;5;6;2;4;4;4;3;5;3;5;6;3;4;5;4;4;3;4;2;8;6;3;5;5;2;4;1;5;4;3;6;5;7;4;4;7;5;2;3;5;8;5;2;6;2;6;5;4;5;5;7;4;4;6;5;5;4;6;6;4;5;4;4;6;7;5;4;5;4;3;7;8;5;5;5;3;5;3;3;2;3;5;3;3;5;3;5;3;4; GO:0034358;GO:0031982;GO:0005615;GO:0034364;GO:0043230;GO:0044421;GO:0043227;GO:1990777;GO:0032994;GO:0070062;GO:0043226;GO:0005576;GO:1903561;GO:0032991;GO:0005575; plasma lipoprotein particle;vesicle;extracellular space;high-density lipoprotein particle;extracellular organelle;extracellular region part;membrane-bounded organelle;lipoprotein particle;protein-lipid complex;extracellular exosome;organelle;extracellular region;extracellular vesicle;macromolecular complex;cellular_component; 3;4;3;4;3;2;3;4;3;4;2;2;3;2;1; GO:0008374;GO:0016740;GO:0016746;GO:0016747;GO:0004623;GO:0004620;GO:0016298;GO:0003674;GO:0016787;GO:0016788;GO:0003824;GO:0004607;GO:0034185;GO:0034186;GO:0052689;GO:0005515;GO:0005488; O-acyltransferase activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups;phospholipase A2 activity;phospholipase activity;lipase activity;molecular_function;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;phosphatidylcholine-sterol O-acyltransferase activity;apolipoprotein binding;apolipoprotein A-I binding;carboxylic ester hydrolase activity;protein binding;binding; 6;3;4;5;6;6;5;1;3;4;2;7;4;5;5;3;2; K00650 map00564; Glycerophospholipid metabolism; IPR003386;IPR029058; Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase;Alpha/Beta hydrolase fold; extracellular Hs4557892 904.0 I [I] Lipid transport and metabolism; P02655 Apolipoprotein C-II OS=Homo sapiens OX=9606 GN=APOC2 PE=1 SV=1 - [APOC2_HUMAN] 0.996 1.015 1.044 0.989 0.978 1.113 0.981280788 0.066203845 1.011247444 0.274739232 1.028571429 0.599309889 1.13803681 3.92E-05 GO:0006775;GO:0019220;GO:0080090;GO:0019222;GO:0051049;GO:0006820;GO:0044281;GO:0044283;GO:0044242;GO:0030100;GO:0071840;GO:0044712;GO:0044710;GO:0044711;GO:1903727;GO:0071830;GO:0045833;GO:0045834;GO:0044093;GO:0044092;GO:0048518;GO:0097006;GO:0033036;GO:0006639;GO:0046503;GO:0006766;GO:0051051;GO:0034367;GO:0034368;GO:0034369;GO:0015711;GO:0007603;GO:0032787;GO:0051129;GO:0023052;GO:0043436;GO:0046486;GO:0030301;GO:0010876;GO:0016192;GO:0044248;GO:0009605;GO:0044707;GO:0019538;GO:0016053;GO:0048878;GO:0048261;GO:0019433;GO:0019637;GO:0009416;GO:0033700;GO:0007165;GO:0009896;GO:0009894;GO:0009892;GO:0034372;GO:0034371;GO:0034370;GO:0015914;GO:0010902;GO:0042157;GO:0010901;GO:0009584;GO:0050789;GO:1901576;GO:1901575;GO:0045937;GO:0051345;GO:0016043;GO:0016042;GO:0065007;GO:0043085;GO:0044700;GO:0065009;GO:0065008;GO:0045723;GO:0051130;GO:0050790;GO:0006629;GO:0006811;GO:0006810;GO:0009889;GO:0051716;GO:0050794;GO:0051128;GO:0010916;GO:0008150;GO:0008152;GO:0042632;GO:0048259;GO:0051234;GO:0046434;GO:0051336;GO:0010915;GO:0060696;GO:0051606;GO:0032368;GO:0032369;GO:0046394;GO:0051241;GO:0050896;GO:0034381;GO:0015850;GO:0009058;GO:0034384;GO:0061365;GO:0010562;GO:0006633;GO:0060193;GO:0006631;GO:0060191;GO:0051239;GO:0006869;GO:0009314;GO:0090207;GO:0006638;GO:0043691;GO:0051004;GO:0044249;GO:0051006;GO:0048519;GO:1903725;GO:0043086;GO:0044699;GO:0009893;GO:0009395;GO:0042304;GO:0015918;GO:0032375;GO:0032374;GO:0051240;GO:0009891;GO:0032371;GO:0010565;GO:0032372;GO:0046464;GO:0046461;GO:0006644;GO:0032501;GO:0090208;GO:0010896;GO:0006721;GO:0006720;GO:0034447;GO:0009987;GO:0060627;GO:0055088;GO:0010898;GO:0016101;GO:0046889;GO:0044255;GO:0032879;GO:0009628;GO:0031331;GO:0006082;GO:0043170;GO:0034382;GO:0015748;GO:0060697;GO:0045923;GO:0006898;GO:0031329;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0019752;GO:0042592;GO:0007602;GO:0046890;GO:0001523;GO:0055090;GO:0071825;GO:0071827;GO:0006641;GO:0072330;GO:0071704;GO:0033344;GO:0071702;GO:0009581;GO:0009582;GO:0009583;GO:0070328;GO:0019217;GO:0019216;GO:0051174;GO:0044765;GO:0044763;GO:0007154;GO:0009056;GO:0051179;GO:1902578;GO:0008610;GO:0006897;GO:0044238;GO:0010985;GO:0042180;GO:0010984;GO:0050994;GO:0044237;GO:0050996;GO:0010518;GO:0006796;GO:0048523;GO:0006793;GO:0055092;GO:0045806;GO:0010517;GO:0048522; fat-soluble vitamin metabolic process;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;anion transport;small molecule metabolic process;small molecule biosynthetic process;cellular lipid catabolic process;regulation of endocytosis;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;positive regulation of phospholipid metabolic process;triglyceride-rich lipoprotein particle clearance;negative regulation of lipid metabolic process;positive regulation of lipid metabolic process;positive regulation of molecular function;negative regulation of molecular function;positive regulation of biological process;regulation of plasma lipoprotein particle levels;macromolecule localization;acylglycerol metabolic process;glycerolipid catabolic process;vitamin metabolic process;negative regulation of transport;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;organic anion transport;phototransduction, visible light;monocarboxylic acid metabolic process;negative regulation of cellular component organization;signaling;oxoacid metabolic process;glycerolipid metabolic process;cholesterol transport;lipid localization;vesicle-mediated transport;cellular catabolic process;response to external stimulus;single-multicellular organism process;protein metabolic process;organic acid biosynthetic process;chemical homeostasis;negative regulation of receptor-mediated endocytosis;triglyceride catabolic process;organophosphate metabolic process;response to light stimulus;phospholipid efflux;signal transduction;positive regulation of catabolic process;regulation of catabolic process;negative regulation of metabolic process;very-low-density lipoprotein particle remodeling;chylomicron remodeling;triglyceride-rich lipoprotein particle remodeling;phospholipid transport;positive regulation of very-low-density lipoprotein particle remodeling;lipoprotein metabolic process;regulation of very-low-density lipoprotein particle remodeling;detection of visible light;regulation of biological process;organic substance biosynthetic process;organic substance catabolic process;positive regulation of phosphate metabolic process;positive regulation of hydrolase activity;cellular component organization;lipid catabolic process;biological regulation;positive regulation of catalytic activity;single organism signaling;regulation of molecular function;regulation of biological quality;positive regulation of fatty acid biosynthetic process;positive regulation of cellular component organization;regulation of catalytic activity;lipid metabolic process;ion transport;transport;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;regulation of cellular component organization;negative regulation of very-low-density lipoprotein particle clearance;biological_process;metabolic process;cholesterol homeostasis;regulation of receptor-mediated endocytosis;establishment of localization;organophosphate catabolic process;regulation of hydrolase activity;regulation of very-low-density lipoprotein particle clearance;regulation of phospholipid catabolic process;detection of stimulus;regulation of lipid transport;negative regulation of lipid transport;carboxylic acid biosynthetic process;negative regulation of multicellular organismal process;response to stimulus;plasma lipoprotein particle clearance;organic hydroxy compound transport;biosynthetic process;high-density lipoprotein particle clearance;positive regulation of triglyceride lipase activity;positive regulation of phosphorus metabolic process;fatty acid biosynthetic process;positive regulation of lipase activity;fatty acid metabolic process;regulation of lipase activity;regulation of multicellular organismal process;lipid transport;response to radiation;regulation of triglyceride metabolic process;neutral lipid metabolic process;reverse cholesterol transport;regulation of lipoprotein lipase activity;cellular biosynthetic process;positive regulation of lipoprotein lipase activity;negative regulation of biological process;regulation of phospholipid metabolic process;negative regulation of catalytic activity;single-organism process;positive regulation of metabolic process;phospholipid catabolic process;regulation of fatty acid biosynthetic process;sterol transport;negative regulation of cholesterol transport;regulation of cholesterol transport;positive regulation of multicellular organismal process;positive regulation of biosynthetic process;regulation of sterol transport;regulation of cellular ketone metabolic process;negative regulation of sterol transport;acylglycerol catabolic process;neutral lipid catabolic process;phospholipid metabolic process;multicellular organismal process;positive regulation of triglyceride metabolic process;regulation of triglyceride catabolic process;terpenoid metabolic process;isoprenoid metabolic process;very-low-density lipoprotein particle clearance;cellular process;regulation of vesicle-mediated transport;lipid homeostasis;positive regulation of triglyceride catabolic process;diterpenoid metabolic process;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;regulation of localization;response to abiotic stimulus;positive regulation of cellular catabolic process;organic acid metabolic process;macromolecule metabolic process;chylomicron remnant clearance;organophosphate ester transport;positive regulation of phospholipid catabolic process;positive regulation of fatty acid metabolic process;receptor-mediated endocytosis;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;homeostatic process;phototransduction;regulation of lipid biosynthetic process;retinoid metabolic process;acylglycerol homeostasis;protein-lipid complex subunit organization;plasma lipoprotein particle organization;triglyceride metabolic process;monocarboxylic acid biosynthetic process;organic substance metabolic process;cholesterol efflux;organic substance transport;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;triglyceride homeostasis;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of phosphorus metabolic process;single-organism transport;single-organism cellular process;cell communication;catabolic process;localization;single-organism localization;lipid biosynthetic process;endocytosis;primary metabolic process;negative regulation of lipoprotein particle clearance;cellular ketone metabolic process;regulation of lipoprotein particle clearance;regulation of lipid catabolic process;cellular metabolic process;positive regulation of lipid catabolic process;positive regulation of phospholipase activity;phosphate-containing compound metabolic process;negative regulation of cellular process;phosphorus metabolic process;sterol homeostasis;negative regulation of endocytosis;regulation of phospholipase activity;positive regulation of cellular process; 6;6;4;3;4;6;4;5;5;5;2;4;3;4;5;5;4;4;4;4;2;3;3;6;6;5;3;5;6;4;6;6;7;4;2;5;5;7;4;5;4;3;3;4;5;5;5;8;4;5;7;4;4;4;3;6;6;5;6;4;5;4;6;2;4;4;6;6;3;5;2;5;3;3;3;6;4;4;4;5;4;4;3;3;4;5;1;2;8;6;3;5;5;5;6;3;5;4;6;3;2;4;5;3;5;8;5;6;7;5;6;3;5;4;5;5;8;7;4;8;2;6;5;2;3;6;6;6;6;7;3;4;6;5;5;7;6;5;2;5;6;6;5;5;2;4;6;6;7;5;4;3;3;5;4;4;6;5;6;5;7;5;5;4;5;4;4;6;4;5;5;8;7;5;4;7;7;3;8;5;4;4;5;8;6;5;5;4;3;4;3;2;3;5;6;3;4;4;4;5;3;5;8;5;3;4;7;4;7;3; GO:0034358;GO:0031982;GO:0034361;GO:0034362;GO:0034364;GO:0043231;GO:0043230;GO:0044421;GO:0043229;GO:0043227;GO:0042627;GO:0005737;GO:0044424;GO:0012505;GO:0034385;GO:0005773;GO:0044444;GO:1990777;GO:0032994;GO:0034366;GO:0005622;GO:0070062;GO:0044464;GO:0005623;GO:0034363;GO:0005615;GO:1903561;GO:0032991;GO:0005575;GO:0005576;GO:0043226;GO:0005768;GO:0005769; plasma lipoprotein particle;vesicle;very-low-density lipoprotein particle;low-density lipoprotein particle;high-density lipoprotein particle;intracellular membrane-bounded organelle;extracellular organelle;extracellular region part;intracellular organelle;membrane-bounded organelle;chylomicron;cytoplasm;intracellular part;endomembrane system;triglyceride-rich lipoprotein particle;vacuole;cytoplasmic part;lipoprotein particle;protein-lipid complex;spherical high-density lipoprotein particle;intracellular;extracellular exosome;cell part;cell;intermediate-density lipoprotein particle;extracellular space;extracellular vesicle;macromolecular complex;cellular_component;extracellular region;organelle;endosome;early endosome; 3;4;5;4;4;4;3;2;3;3;4;4;3;3;4;5;4;4;3;5;3;4;2;2;5;3;3;2;1;2;2;4;5; GO:0098772;GO:0060229;GO:0055102;GO:0046983;GO:0019899;GO:0004857;GO:0042802;GO:0008289;GO:0043274;GO:0005515;GO:0003674;GO:0042803;GO:0005488;GO:0008047;GO:0016004;GO:0030234;GO:0060230; molecular function regulator;lipase activator activity;lipase inhibitor activity;protein dimerization activity;enzyme binding;enzyme inhibitor activity;identical protein binding;lipid binding;phospholipase binding;protein binding;molecular_function;protein homodimerization activity;binding;enzyme activator activity;phospholipase activator activity;enzyme regulator activity;lipoprotein lipase activator activity; 2;5;5;4;4;4;4;3;5;3;1;5;2;4;6;3;6; K22287 IPR008019; Apolipoprotein C-II; extracellular P35858 Insulin-like growth factor-binding protein complex acid labile subunit OS=Homo sapiens OX=9606 GN=IGFALS PE=1 SV=1 - [ALS_HUMAN] 1.126 1.009 0.921 1.097 0.995 1.092 1.115956392 1.77E-05 1.102512563 0.000226757 0.912784936 0.614756596 1.097487437 0.00591594 GO:0023052;GO:0044699;GO:0044267;GO:0051716;GO:0044260;GO:0050789;GO:0071704;GO:0065007;GO:0022610;GO:0044700;GO:0009987;GO:0050794;GO:0008150;GO:0008152;GO:0007155;GO:0007154;GO:0044238;GO:0019538;GO:0050896;GO:0044237;GO:0043170;GO:0044763;GO:0007165; signaling;single-organism process;cellular protein metabolic process;cellular response to stimulus;cellular macromolecule metabolic process;regulation of biological process;organic substance metabolic process;biological regulation;biological adhesion;single organism signaling;cellular process;regulation of cellular process;biological_process;metabolic process;cell adhesion;cell communication;primary metabolic process;protein metabolic process;response to stimulus;cellular metabolic process;macromolecule metabolic process;single-organism cellular process;signal transduction; 2;2;5;3;4;2;3;2;2;3;2;3;1;2;3;4;3;4;2;3;4;3;4; GO:0031974;GO:0042567;GO:0043229;GO:0005623;GO:0005622;GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0005634;GO:0005654;GO:0005575;GO:0032991;GO:0036454;GO:1903561;GO:0031982;GO:0043234;GO:0043230;GO:0043231;GO:0016942;GO:0043233;GO:0031981;GO:0044464;GO:0044446;GO:0070013;GO:0005576;GO:0044428;GO:0044424;GO:0044421;GO:0044422; membrane-enclosed lumen;insulin-like growth factor ternary complex;intracellular organelle;cell;intracellular;membrane-bounded organelle;organelle;extracellular exosome;extracellular space;nucleus;nucleoplasm;cellular_component;macromolecular complex;growth factor complex;extracellular vesicle;vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;insulin-like growth factor binding protein complex;organelle lumen;nuclear lumen;cell part;intracellular organelle part;intracellular organelle lumen;extracellular region;nuclear part;intracellular part;extracellular region part;organelle part; 2;4;3;2;3;3;2;4;3;5;5;1;2;4;3;4;3;3;4;3;3;5;2;3;4;2;4;3;2;2; GO:0005488;GO:0003674;GO:0019838;GO:0005520;GO:0005515; binding;molecular_function;growth factor binding;insulin-like growth factor binding;protein binding; 2;1;4;5;3; K17256 IPR003591;IPR001611;IPR000483;IPR000372;IPR032675; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat N-terminal domain;Leucine-rich repeat domain, L domain-like; extracellular Hs4826772 1186.0 R [R] General function prediction only; Q15485 Ficolin-2 OS=Homo sapiens OX=9606 GN=FCN2 PE=1 SV=2 - [FCN2_HUMAN] 1.239 0.88 1.076 1.177 0.831 0.945 1.407954545 nan 1.416365824 nan 1.222727273 nan 1.137184116 nan GO:0009607;GO:0006909;GO:0043654;GO:0048584;GO:0050778;GO:0043277;GO:0050829;GO:0043170;GO:0050789;GO:0044699;GO:0044710;GO:0006959;GO:0050830;GO:0043207;GO:0072376;GO:0009617;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:0051704;GO:0008037;GO:0009987;GO:0006956;GO:0002253;GO:0044238;GO:0048583;GO:0045087;GO:0006810;GO:0006910;GO:0006952;GO:0044765;GO:0008150;GO:0008152;GO:0006955;GO:0006897;GO:0001867;GO:0051234;GO:0051707;GO:0051179;GO:1902578;GO:0050776;GO:0016192;GO:0009605;GO:0050896;GO:0044763;GO:0006950;GO:0002376;GO:0019538;GO:0002252;GO:0008228;GO:0098542;GO:0042742; response to biotic stimulus;phagocytosis;recognition of apoptotic cell;positive regulation of response to stimulus;positive regulation of immune response;apoptotic cell clearance;defense response to Gram-negative bacterium;macromolecule metabolic process;regulation of biological process;single-organism process;single-organism metabolic process;humoral immune response;defense response to Gram-positive bacterium;response to external biotic stimulus;protein activation cascade;response to bacterium;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;multi-organism process;cell recognition;cellular process;complement activation;activation of immune response;primary metabolic process;regulation of response to stimulus;innate immune response;transport;phagocytosis, recognition;defense response;single-organism transport;biological_process;metabolic process;immune response;endocytosis;complement activation, lectin pathway;establishment of localization;response to other organism;localization;single-organism localization;regulation of immune response;vesicle-mediated transport;response to external stimulus;response to stimulus;single-organism cellular process;response to stress;immune system process;protein metabolic process;immune effector process;opsonization;defense response to other organism;defense response to bacterium; 3;5;6;3;4;6;6;4;2;2;3;4;6;4;3;4;3;3;3;2;2;2;4;2;4;3;3;3;4;4;5;4;4;1;2;3;6;5;3;3;2;3;4;5;3;2;3;3;2;4;3;4;4;5; GO:0043226;GO:0043227;GO:0005575;GO:0005581;GO:0072562;GO:0031982;GO:0043230;GO:0005615;GO:0043234;GO:0032991;GO:0070062;GO:1903561;GO:0005576;GO:0044421; organelle;membrane-bounded organelle;cellular_component;collagen trimer;blood microparticle;vesicle;extracellular organelle;extracellular space;protein complex;macromolecular complex;extracellular exosome;extracellular vesicle;extracellular region;extracellular region part; 2;3;1;4;3;4;3;3;3;2;4;3;2;2; GO:0003823;GO:0048306;GO:0030247;GO:0030246;GO:0046872;GO:0003674;GO:0005488;GO:0001948;GO:0043167;GO:0043169;GO:0043394;GO:2001065;GO:0097367;GO:0001871;GO:0005515; antigen binding;calcium-dependent protein binding;polysaccharide binding;carbohydrate binding;metal ion binding;molecular_function;binding;glycoprotein binding;ion binding;cation binding;proteoglycan binding;mannan binding;carbohydrate derivative binding;pattern binding;protein binding; 3;4;4;3;5;1;2;4;3;4;5;5;3;3;3; K10104 IPR002181;IPR014716;IPR014715;IPR020837;IPR008160; Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, conserved site;Collagen triple helix repeat; extracellular Hs4758348 645.0 R [R] General function prediction only; P02656 Apolipoprotein C-III OS=Homo sapiens OX=9606 GN=APOC3 PE=1 SV=1 - [APOC3_HUMAN] 1.05 0.967 1.036 1.013 1.01 1.063 1.085832472 0.061901181 1.002970297 0.858488225 1.071354705 0.031419785 1.052475248 2.29E-05 GO:0051049;GO:0009167;GO:0044281;GO:0009161;GO:0051716;GO:0009199;GO:0016101;GO:0046503;GO:0046486;GO:0046483;GO:0042325;GO:0042326;GO:0009605;GO:0034284;GO:0019538;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0044283;GO:0010901;GO:0035556;GO:0050789;GO:0010867;GO:0010866;GO:0048261;GO:0051346;GO:0097006;GO:0071840;GO:0006119;GO:0006629;GO:0032489;GO:0032488;GO:0051241;GO:0006753;GO:0044085;GO:0046578;GO:0051129;GO:0051128;GO:0009416;GO:0014070;GO:0033273;GO:0046889;GO:0044255;GO:0046394;GO:0045922;GO:0006898;GO:0042592;GO:0042593;GO:0002082;GO:0006091;GO:0055092;GO:0055090;GO:0033993;GO:0019217;GO:0019216;GO:0019219;GO:0044765;GO:0044763;GO:0071830;GO:0030100;GO:1901700;GO:1901701;GO:0050995;GO:0050994;GO:0019693;GO:0006796;GO:0006793;GO:0006140;GO:0048523;GO:0048522;GO:0006633;GO:0008104;GO:0034447;GO:1903579;GO:1903578;GO:0007165;GO:0044712;GO:0044710;GO:0044711;GO:0071331;GO:0044092;GO:0033036;GO:0051055;GO:0034367;GO:0034368;GO:0034369;GO:0071702;GO:0030301;GO:0010033;GO:0044248;GO:0044249;GO:0031667;GO:0045717;GO:0090324;GO:0015918;GO:0015850;GO:0015914;GO:0016053;GO:0006807;GO:0007186;GO:0050790;GO:0009889;GO:0050794;GO:0010915;GO:0010916;GO:0051239;GO:0051234;GO:0034014;GO:0051336;GO:0051174;GO:0006897;GO:0032368;GO:0032369;GO:0034382;GO:0034383;GO:0050896;GO:0034381;GO:0034384;GO:0010988;GO:0010989;GO:0010987;GO:0010984;GO:0010985;GO:0010982;GO:0051171;GO:0060192;GO:0006631;GO:0060191;GO:0009314;GO:0006639;GO:0006638;GO:0070887;GO:0009259;GO:0044699;GO:0010563;GO:0010565;GO:1901135;GO:0042493;GO:0010903;GO:0043933;GO:0046890;GO:0072521;GO:0001523;GO:0072330;GO:0033189;GO:0045934;GO:0045936;GO:0007266;GO:0007265;GO:0007264;GO:0008610;GO:0009746;GO:0009628;GO:0009743;GO:0044237;GO:0009749;GO:0045806;GO:0006775;GO:0019220;GO:0019222;GO:0048583;GO:0035376;GO:0045980;GO:1901360;GO:0009966;GO:0048518;GO:0048519;GO:0036273;GO:0015711;GO:0007603;GO:0007602;GO:0045184;GO:0042221;GO:0043436;GO:0043434;GO:0044700;GO:1901564;GO:0016192;GO:0044707;GO:0071322;GO:0010243;GO:0071326;GO:0070508;GO:0019637;GO:0034377;GO:0034375;GO:0022607;GO:0034372;GO:0034370;GO:0009141;GO:0009144;GO:0034379;GO:0044872;GO:0042157;GO:0034763;GO:0033700;GO:0006811;GO:0006810;GO:0006952;GO:0006950;GO:0001678;GO:1902531;GO:0051606;GO:0090209;GO:0006954;GO:0090207;GO:0035023;GO:0006139;GO:0042304;GO:0032375;GO:0032374;GO:0042278;GO:0032371;GO:0032372;GO:0045978;GO:0032501;GO:0006641;GO:0031330;GO:0006720;GO:0009987;GO:0006725;GO:0060627;GO:0032879;GO:0070542;GO:0051056;GO:2000910;GO:0045017;GO:0051051;GO:0043467;GO:0071704;GO:0071310;GO:0046034;GO:0007584;GO:0009058;GO:0071827;GO:0009117;GO:0009116;GO:0051172;GO:0009119;GO:0009118;GO:0009056;GO:0051179;GO:1902578;GO:0042180;GO:1901657;GO:1901652;GO:0080090;GO:0006820;GO:0034762;GO:0090208;GO:0045833;GO:0045834;GO:0010896;GO:0010897;GO:0019725;GO:0009205;GO:0006766;GO:0032787;GO:0046128;GO:0010876;GO:0048878;GO:0006163;GO:0019433;GO:0019432;GO:0071333;GO:0070328;GO:1901576;GO:1901575;GO:0016043;GO:0016042;GO:0065003;GO:0065007;GO:0065005;GO:0065009;GO:0065008;GO:0009719;GO:0009150;GO:0008150;GO:0008152;GO:0042632;GO:0048259;GO:1901698;GO:0006869;GO:0016310;GO:0043691;GO:0051004;GO:0051005;GO:0034641;GO:0023052;GO:0023051;GO:0009123;GO:0044242;GO:0010646;GO:0009126;GO:0043086;GO:0046464;GO:0046463;GO:0046460;GO:0046461;GO:0044238;GO:0055088;GO:0001101;GO:0055082;GO:0055085;GO:0055086;GO:0006082;GO:0009725;GO:0043170;GO:0042953;GO:0009991;GO:0031329;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0019752;GO:0060620;GO:0071825;GO:1903491;GO:0033500;GO:0006721;GO:0060621;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0007154;GO:2000909;GO:1900543;GO:1900542;GO:0033344;GO:0015748;GO:0015031; regulation of transport;purine ribonucleoside monophosphate metabolic process;small molecule metabolic process;ribonucleoside monophosphate metabolic process;cellular response to stimulus;ribonucleoside triphosphate metabolic process;diterpenoid metabolic process;glycerolipid catabolic process;glycerolipid metabolic process;heterocycle metabolic process;regulation of phosphorylation;negative regulation of phosphorylation;response to external stimulus;response to monosaccharide;protein metabolic process;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;small molecule biosynthetic process;regulation of very-low-density lipoprotein particle remodeling;intracellular signal transduction;regulation of biological process;positive regulation of triglyceride biosynthetic process;regulation of triglyceride biosynthetic process;negative regulation of receptor-mediated endocytosis;negative regulation of hydrolase activity;regulation of plasma lipoprotein particle levels;cellular component organization or biogenesis;oxidative phosphorylation;lipid metabolic process;regulation of Cdc42 protein signal transduction;Cdc42 protein signal transduction;negative regulation of multicellular organismal process;nucleoside phosphate metabolic process;cellular component biogenesis;regulation of Ras protein signal transduction;negative regulation of cellular component organization;regulation of cellular component organization;response to light stimulus;response to organic cyclic compound;response to vitamin;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;carboxylic acid biosynthetic process;negative regulation of fatty acid metabolic process;receptor-mediated endocytosis;homeostatic process;glucose homeostasis;regulation of oxidative phosphorylation;generation of precursor metabolites and energy;sterol homeostasis;acylglycerol homeostasis;response to lipid;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;single-organism transport;single-organism cellular process;triglyceride-rich lipoprotein particle clearance;regulation of endocytosis;response to oxygen-containing compound;cellular response to oxygen-containing compound;negative regulation of lipid catabolic process;regulation of lipid catabolic process;ribose phosphate metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of nucleotide metabolic process;negative regulation of cellular process;positive regulation of cellular process;fatty acid biosynthetic process;protein localization;very-low-density lipoprotein particle clearance;negative regulation of ATP metabolic process;regulation of ATP metabolic process;signal transduction;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular response to hexose stimulus;negative regulation of molecular function;macromolecule localization;negative regulation of lipid biosynthetic process;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;organic substance transport;cholesterol transport;response to organic substance;cellular catabolic process;cellular biosynthetic process;response to nutrient levels;negative regulation of fatty acid biosynthetic process;negative regulation of oxidative phosphorylation;sterol transport;organic hydroxy compound transport;phospholipid transport;organic acid biosynthetic process;nitrogen compound metabolic process;G-protein coupled receptor signaling pathway;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of very-low-density lipoprotein particle clearance;negative regulation of very-low-density lipoprotein particle clearance;regulation of multicellular organismal process;establishment of localization;response to triglyceride;regulation of hydrolase activity;regulation of phosphorus metabolic process;endocytosis;regulation of lipid transport;negative regulation of lipid transport;chylomicron remnant clearance;low-density lipoprotein particle clearance;response to stimulus;plasma lipoprotein particle clearance;high-density lipoprotein particle clearance;regulation of low-density lipoprotein particle clearance;negative regulation of low-density lipoprotein particle clearance;negative regulation of high-density lipoprotein particle clearance;regulation of lipoprotein particle clearance;negative regulation of lipoprotein particle clearance;regulation of high-density lipoprotein particle clearance;regulation of nitrogen compound metabolic process;negative regulation of lipase activity;fatty acid metabolic process;regulation of lipase activity;response to radiation;acylglycerol metabolic process;neutral lipid metabolic process;cellular response to chemical stimulus;ribonucleotide metabolic process;single-organism process;negative regulation of phosphorus metabolic process;regulation of cellular ketone metabolic process;carbohydrate derivative metabolic process;response to drug;negative regulation of very-low-density lipoprotein particle remodeling;macromolecular complex subunit organization;regulation of lipid biosynthetic process;purine-containing compound metabolic process;retinoid metabolic process;monocarboxylic acid biosynthetic process;response to vitamin A;negative regulation of nucleobase-containing compound metabolic process;negative regulation of phosphate metabolic process;Rho protein signal transduction;Ras protein signal transduction;small GTPase mediated signal transduction;lipid biosynthetic process;response to hexose;response to abiotic stimulus;response to carbohydrate;cellular metabolic process;response to glucose;negative regulation of endocytosis;fat-soluble vitamin metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;regulation of response to stimulus;sterol import;negative regulation of nucleotide metabolic process;organic cyclic compound metabolic process;regulation of signal transduction;positive regulation of biological process;negative regulation of biological process;response to statin;organic anion transport;phototransduction, visible light;phototransduction;establishment of protein localization;response to chemical;oxoacid metabolic process;response to peptide hormone;single organism signaling;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;cellular response to carbohydrate stimulus;response to organonitrogen compound;cellular response to monosaccharide stimulus;cholesterol import;organophosphate metabolic process;plasma lipoprotein particle assembly;high-density lipoprotein particle remodeling;cellular component assembly;very-low-density lipoprotein particle remodeling;triglyceride-rich lipoprotein particle remodeling;nucleoside triphosphate metabolic process;purine nucleoside triphosphate metabolic process;very-low-density lipoprotein particle assembly;lipoprotein localization;lipoprotein metabolic process;negative regulation of transmembrane transport;phospholipid efflux;ion transport;transport;defense response;response to stress;cellular glucose homeostasis;regulation of intracellular signal transduction;detection of stimulus;negative regulation of triglyceride metabolic process;inflammatory response;regulation of triglyceride metabolic process;regulation of Rho protein signal transduction;nucleobase-containing compound metabolic process;regulation of fatty acid biosynthetic process;negative regulation of cholesterol transport;regulation of cholesterol transport;purine nucleoside metabolic process;regulation of sterol transport;negative regulation of sterol transport;negative regulation of nucleoside metabolic process;multicellular organismal process;triglyceride metabolic process;negative regulation of cellular catabolic process;isoprenoid metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of vesicle-mediated transport;regulation of localization;response to fatty acid;regulation of small GTPase mediated signal transduction;negative regulation of sterol import;glycerolipid biosynthetic process;negative regulation of transport;regulation of generation of precursor metabolites and energy;organic substance metabolic process;cellular response to organic substance;ATP metabolic process;response to nutrient;biosynthetic process;plasma lipoprotein particle organization;nucleotide metabolic process;nucleoside metabolic process;negative regulation of nitrogen compound metabolic process;ribonucleoside metabolic process;regulation of nucleoside metabolic process;catabolic process;localization;single-organism localization;cellular ketone metabolic process;glycosyl compound metabolic process;response to peptide;regulation of primary metabolic process;anion transport;regulation of transmembrane transport;positive regulation of triglyceride metabolic process;negative regulation of lipid metabolic process;positive regulation of lipid metabolic process;regulation of triglyceride catabolic process;negative regulation of triglyceride catabolic process;cellular homeostasis;purine ribonucleoside triphosphate metabolic process;vitamin metabolic process;monocarboxylic acid metabolic process;purine ribonucleoside metabolic process;lipid localization;chemical homeostasis;purine nucleotide metabolic process;triglyceride catabolic process;triglyceride biosynthetic process;cellular response to glucose stimulus;triglyceride homeostasis;organic substance biosynthetic process;organic substance catabolic process;cellular component organization;lipid catabolic process;macromolecular complex assembly;biological regulation;protein-lipid complex assembly;regulation of molecular function;regulation of biological quality;response to endogenous stimulus;purine ribonucleotide metabolic process;biological_process;metabolic process;cholesterol homeostasis;regulation of receptor-mediated endocytosis;response to nitrogen compound;lipid transport;phosphorylation;reverse cholesterol transport;regulation of lipoprotein lipase activity;negative regulation of lipoprotein lipase activity;cellular nitrogen compound metabolic process;signaling;regulation of signaling;nucleoside monophosphate metabolic process;cellular lipid catabolic process;regulation of cell communication;purine nucleoside monophosphate metabolic process;negative regulation of catalytic activity;acylglycerol catabolic process;acylglycerol biosynthetic process;neutral lipid biosynthetic process;neutral lipid catabolic process;primary metabolic process;lipid homeostasis;response to acid chemical;cellular chemical homeostasis;transmembrane transport;nucleobase-containing small molecule metabolic process;organic acid metabolic process;response to hormone;macromolecule metabolic process;lipoprotein transport;response to extracellular stimulus;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;regulation of cholesterol import;protein-lipid complex subunit organization;response to simvastatin;carbohydrate homeostasis;terpenoid metabolic process;negative regulation of cholesterol import;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;cell communication;regulation of sterol import;negative regulation of purine nucleotide metabolic process;regulation of purine nucleotide metabolic process;cholesterol efflux;organophosphate ester transport;protein transport; 4;8;4;7;3;7;7;6;5;4;7;7;3;6;4;4;4;3;3;4;4;5;4;5;2;6;6;5;6;3;2;5;4;9;9;3;5;3;7;4;4;5;5;5;5;4;6;5;7;4;7;6;4;7;7;5;6;5;5;4;3;5;5;4;5;5;5;5;5;4;6;3;3;6;4;5;7;7;4;4;3;4;8;4;3;5;5;6;4;5;7;4;4;4;5;6;6;6;5;6;5;3;5;4;4;3;5;5;3;3;5;5;5;6;5;4;6;5;2;4;5;5;5;5;4;4;5;4;7;5;6;4;6;5;4;6;2;5;5;4;4;4;4;5;5;8;7;6;5;6;8;7;6;5;7;3;5;3;8;4;6;6;3;3;7;6;4;4;2;2;5;6;6;5;4;3;5;5;3;4;5;3;6;4;7;8;4;4;5;4;6;5;6;7;5;5;5;4;7;5;4;4;3;6;5;3;5;5;5;8;4;6;6;7;6;6;5;6;2;7;5;5;2;4;4;3;5;6;5;5;3;5;3;5;8;4;3;4;6;5;4;6;6;3;2;3;4;4;5;4;6;4;5;4;4;6;6;4;8;5;7;7;4;5;6;8;7;7;8;4;4;3;5;5;2;6;3;3;3;7;1;2;8;6;4;5;6;8;7;8;4;2;3;6;5;4;7;5;7;6;5;6;3;6;4;5;4;4;4;4;4;5;4;5;5;5;5;4;4;4;6;6;5;6;6;6;6;4;4;5;6;4;5;7;7;8;5;5; GO:0034358;GO:0044424;GO:0044421;GO:0005773;GO:0044464;GO:0005615;GO:0070062;GO:0005737;GO:0005768;GO:0005769;GO:0034361;GO:0034363;GO:0034364;GO:0034366;GO:0043230;GO:0043231;GO:0034385;GO:1990777;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0042627;GO:0012505;GO:0044444;GO:0031982;GO:0005623;GO:0005576;GO:1903561;GO:0032994;GO:0032991;GO:0005575; plasma lipoprotein particle;intracellular part;extracellular region part;vacuole;cell part;extracellular space;extracellular exosome;cytoplasm;endosome;early endosome;very-low-density lipoprotein particle;intermediate-density lipoprotein particle;high-density lipoprotein particle;spherical high-density lipoprotein particle;extracellular organelle;intracellular membrane-bounded organelle;triglyceride-rich lipoprotein particle;lipoprotein particle;intracellular organelle;intracellular;membrane-bounded organelle;organelle;chylomicron;endomembrane system;cytoplasmic part;vesicle;cell;extracellular region;extracellular vesicle;protein-lipid complex;macromolecular complex;cellular_component; 3;3;2;5;2;3;4;4;4;5;5;5;4;5;3;4;4;4;3;3;3;2;4;3;4;4;2;2;3;3;2;1; GO:0098772;GO:0005488;GO:0008289;GO:0043167;GO:0005543;GO:0030234;GO:0004857;GO:0005515;GO:0005102;GO:0070653;GO:0003674;GO:0097159;GO:0043168;GO:0032934;GO:0036094;GO:0005496;GO:0015485;GO:0055102;GO:0043178;GO:0070325; molecular function regulator;binding;lipid binding;ion binding;phospholipid binding;enzyme regulator activity;enzyme inhibitor activity;protein binding;receptor binding;high-density lipoprotein particle receptor binding;molecular_function;organic cyclic compound binding;anion binding;sterol binding;small molecule binding;steroid binding;cholesterol binding;lipase inhibitor activity;alcohol binding;lipoprotein particle receptor binding; 2;2;3;3;4;3;4;3;4;6;1;3;4;5;3;4;6;5;4;5; K08759 map03320; PPAR signaling pathway; IPR008403; Apolipoprotein CIII; extracellular Q9H7P9 Pleckstrin homology domain-containing family G member 2 OS=Homo sapiens OX=9606 GN=PLEKHG2 PE=1 SV=3 - [PKHG2_HUMAN] 1.018 1.074 0.942 1.053 1.091 1.043 0.947858473 0.676750477 0.965169569 0.518024608 0.877094972 0.52894791 0.956003666 0.821200307 GO:0007166;GO:0035023;GO:0048583;GO:0007266;GO:0007165;GO:0070887;GO:0023051;GO:0010942;GO:0007169;GO:0035556;GO:0042981;GO:0050789;GO:0044699;GO:0043065;GO:0051716;GO:0007264;GO:0010646;GO:0009966;GO:0070848;GO:0008219;GO:0071310;GO:0008150;GO:0043067;GO:0065007;GO:0046578;GO:0048518;GO:0097190;GO:0043068;GO:0051056;GO:0006915;GO:0038179;GO:0007167;GO:0009987;GO:0050794;GO:0012501;GO:0042221;GO:0044763;GO:0048011;GO:0007154;GO:0007265;GO:1902531;GO:0010033;GO:0044700;GO:0071363;GO:0050896;GO:0023052;GO:0010941;GO:0048522; cell surface receptor signaling pathway;regulation of Rho protein signal transduction;regulation of response to stimulus;Rho protein signal transduction;signal transduction;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell death;transmembrane receptor protein tyrosine kinase signaling pathway;intracellular signal transduction;regulation of apoptotic process;regulation of biological process;single-organism process;positive regulation of apoptotic process;cellular response to stimulus;small GTPase mediated signal transduction;regulation of cell communication;regulation of signal transduction;response to growth factor;cell death;cellular response to organic substance;biological_process;regulation of programmed cell death;biological regulation;regulation of Ras protein signal transduction;positive regulation of biological process;apoptotic signaling pathway;positive regulation of programmed cell death;regulation of small GTPase mediated signal transduction;apoptotic process;neurotrophin signaling pathway;enzyme linked receptor protein signaling pathway;cellular process;regulation of cellular process;programmed cell death;response to chemical;single-organism cellular process;neurotrophin TRK receptor signaling pathway;cell communication;Ras protein signal transduction;regulation of intracellular signal transduction;response to organic substance;single organism signaling;cellular response to growth factor stimulus;response to stimulus;signaling;regulation of cell death;positive regulation of cellular process; 5;8;3;8;4;4;3;4;7;5;6;2;2;6;3;6;4;4;5;4;5;1;5;2;7;2;5;5;6;6;6;6;2;3;5;3;3;7;4;7;5;4;3;6;2;2;4;3; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0005829; cytoplasm;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;cytosol; 4;2;2;3;1;4;3;5; GO:0005089;GO:0005088;GO:0003674;GO:0098772;GO:0005085; Rho guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;molecular_function;molecular function regulator;guanyl-nucleotide exchange factor activity; 5;4;1;2;3; IPR001849;IPR011993;IPR000219; Pleckstrin homology domain;PH domain-like;Dbl homology (DH) domain; nucleus Hs18562992_1 354.0 R [R] General function prediction only; P04433 Immunoglobulin kappa variable 3-11 OS=Homo sapiens OX=9606 GN=IGKV3-11 PE=1 SV=1 - [KV311_HUMAN] 0.952 1.124 0.947 0.951 1.157 1.06 0.846975089 1.33E-05 0.821953328 0.00109408 0.84252669 0.000137089 0.916162489 0.153778715 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P04430 Immunoglobulin kappa variable 1-16 OS=Homo sapiens OX=9606 GN=IGKV1-16 PE=1 SV=2 - [KV116_HUMAN] 1.067 1.09 0.914 1.048 1.018 1.296 0.978899083 0.789506022 1.029469548 0.939708807 0.83853211 0.165535767 1.273084479 0.026777452 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P31350 Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1 - [RIR2_HUMAN] 0.789 0.956 0.64 1.095 0.875 4.294 0.825313808 nan 1.251428571 nan 0.669456067 nan 4.907428571 nan GO:0080090;GO:0019222;GO:0000082;GO:0000083;GO:0009165;GO:0044281;GO:1901362;GO:1901360;GO:0044710;GO:0044711;GO:0006260;GO:0060255;GO:0051291;GO:0051290;GO:2001141;GO:0046483;GO:0019637;GO:0019438;GO:0022607;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:0071840;GO:0018130;GO:0009889;GO:0050794;GO:0009263;GO:0009262;GO:0008150;GO:0008152;GO:0034654;GO:0090407;GO:0016070;GO:0044271;GO:0006355;GO:0006351;GO:0009117;GO:0006753;GO:0032774;GO:0070271;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0009987;GO:0006725;GO:1903506;GO:0009132;GO:0055086;GO:0051259;GO:0090304;GO:0007049;GO:1901137;GO:1901135;GO:0051252;GO:0009186;GO:0043933;GO:0031326;GO:0031323;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0071822;GO:2000112;GO:0051262;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:1901293;GO:0000278;GO:0019219;GO:0006461;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0015949;GO:0044843;GO:0044238;GO:0044237;GO:0006796;GO:0044085;GO:0006793;GO:0006259; regulation of primary metabolic process;regulation of metabolic process;G1/S transition of mitotic cell cycle;regulation of transcription involved in G1/S transition of mitotic cell cycle;nucleotide biosynthetic process;small molecule metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;DNA replication;regulation of macromolecule metabolic process;protein heterooligomerization;protein heterotetramerization;regulation of RNA biosynthetic process;heterocycle metabolic process;organophosphate metabolic process;aromatic compound biosynthetic process;cellular component assembly;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;deoxyribonucleotide biosynthetic process;deoxyribonucleotide metabolic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;organophosphate biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;transcription, DNA-templated;nucleotide metabolic process;nucleoside phosphate metabolic process;RNA biosynthetic process;protein complex biogenesis;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;nucleoside diphosphate metabolic process;nucleobase-containing small molecule metabolic process;protein oligomerization;nucleic acid metabolic process;cell cycle;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;deoxyribonucleoside diphosphate metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;protein complex subunit organization;regulation of cellular macromolecule biosynthetic process;protein tetramerization;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;nucleoside phosphate biosynthetic process;mitotic cell cycle;regulation of nucleobase-containing compound metabolic process;protein complex assembly;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;nucleobase-containing small molecule interconversion;cell cycle G1/S phase transition;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process;DNA metabolic process; 4;3;7;6;6;4;5;4;3;4;6;4;7;8;6;4;4;5;4;3;4;2;7;4;4;3;5;2;2;5;4;3;6;5;1;2;5;5;5;5;6;6;6;5;6;4;4;4;5;2;4;2;4;7;6;4;6;5;4;5;4;5;7;4;5;4;5;5;6;4;5;6;7;3;5;5;5;5;5;5;5;3;5;3;4;5;6;3;3;5;3;4;5; GO:0031974;GO:0005654;GO:0031981;GO:1902494;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044422;GO:0043229;GO:0043227;GO:0044424;GO:0044446;GO:0044444;GO:0044445;GO:1990204;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005971;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nucleoplasm;nuclear lumen;catalytic complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;organelle part;intracellular organelle;membrane-bounded organelle;intracellular part;intracellular organelle part;cytoplasmic part;cytosolic part;oxidoreductase complex;cytoplasm;nucleus;cell part;cell;intracellular;organelle;ribonucleoside-diphosphate reductase complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;5;4;3;4;3;5;4;2;3;3;3;3;4;5;3;4;5;2;2;3;2;4;2;1;4; GO:0046872;GO:0061731;GO:0003674;GO:0005488;GO:0043169;GO:0003824;GO:0016491;GO:0043167;GO:0004748;GO:0016725;GO:0016728; metal ion binding;ribonucleoside-diphosphate reductase activity;molecular_function;binding;cation binding;catalytic activity;oxidoreductase activity;ion binding;ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;oxidoreductase activity, acting on CH or CH2 groups;oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor; 5;6;1;2;4;2;3;3;7;4;5; K10808 map00230;map00240;map00480;map01100;map04115; Purine metabolism;Pyrimidine metabolism;Glutathione metabolism;Metabolic pathways;p53 signaling pathway; IPR033909;IPR009078;IPR030475;IPR000358; Ribonucleotide reductase small subunit;Ferritin-like superfamily;Ribonucleotide reductase small subunit, acitve site;Ribonucleotide reductase small subunit family; cytosol Hs4557845 805.0 F [F] Nucleotide transport and metabolism; Q08345 Epithelial discoidin domain-containing receptor 1 OS=Homo sapiens OX=9606 GN=DDR1 PE=1 SV=1 - [DDR1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0061302;GO:0022617;GO:0007595;GO:0007160;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0051716;GO:0018212;GO:0009611;GO:0018193;GO:0048513;GO:0048519;GO:0042127;GO:0031589;GO:0043062;GO:0031100;GO:0044702;GO:0002011;GO:0051704;GO:0044700;GO:0044703;GO:0016477;GO:0044707;GO:0048870;GO:0019538;GO:0044706;GO:0014812;GO:0030198;GO:0007565;GO:0038063;GO:0038065;GO:0032941;GO:0044319;GO:0050789;GO:0044267;GO:0016049;GO:0044260;GO:0061138;GO:0016043;GO:0065007;GO:0065008;GO:0030879;GO:0009887;GO:0006810;GO:0009888;GO:0042060;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0060603;GO:0008152;GO:0051234;GO:0000003;GO:0046903;GO:0007423;GO:0050896;GO:0006950;GO:0022411;GO:0016310;GO:0030155;GO:0051128;GO:0023052;GO:0009653;GO:0046777;GO:0044699;GO:0038083;GO:0031099;GO:0060443;GO:0060444;GO:0022612;GO:0061377;GO:0022610;GO:0032502;GO:0008285;GO:0032501;GO:0035239;GO:0050878;GO:0008283;GO:1903053;GO:0009987;GO:0001558;GO:0048754;GO:0060562;GO:0060749;GO:0006928;GO:0051674;GO:0090504;GO:0007566;GO:0001952;GO:0043170;GO:0001763;GO:0048731;GO:0048732;GO:0010715;GO:0061180;GO:0090505;GO:0018108;GO:0014909;GO:0007275;GO:0002009;GO:0071704;GO:0043583;GO:0048729;GO:0043588;GO:0006468;GO:0060429;GO:0007589;GO:0010810;GO:0006464;GO:0044767;GO:0022414;GO:0044765;GO:0044763;GO:0007155;GO:0007154;GO:0035295;GO:0051179;GO:1902578;GO:0040007;GO:0040011;GO:0044238;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:0040008;GO:0048523; smooth muscle cell-matrix adhesion;extracellular matrix disassembly;lactation;cell-matrix adhesion;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;peptidyl-tyrosine modification;response to wounding;peptidyl-amino acid modification;animal organ development;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;extracellular structure organization;organ regeneration;single organism reproductive process;morphogenesis of an epithelial sheet;multi-organism process;single organism signaling;multi-organism reproductive process;cell migration;single-multicellular organism process;cell motility;protein metabolic process;multi-multicellular organism process;muscle cell migration;extracellular matrix organization;female pregnancy;collagen-activated tyrosine kinase receptor signaling pathway;collagen-activated signaling pathway;secretion by tissue;wound healing, spreading of cells;regulation of biological process;cellular protein metabolic process;cell growth;cellular macromolecule metabolic process;morphogenesis of a branching epithelium;cellular component organization;biological regulation;regulation of biological quality;mammary gland development;organ morphogenesis;transport;tissue development;wound healing;regulation of cellular process;macromolecule modification;protein modification process;biological_process;mammary gland duct morphogenesis;metabolic process;establishment of localization;reproduction;secretion;sensory organ development;response to stimulus;response to stress;cellular component disassembly;phosphorylation;regulation of cell adhesion;regulation of cellular component organization;signaling;anatomical structure morphogenesis;protein autophosphorylation;single-organism process;peptidyl-tyrosine autophosphorylation;regeneration;mammary gland morphogenesis;branching involved in mammary gland duct morphogenesis;gland morphogenesis;mammary gland lobule development;biological adhesion;developmental process;negative regulation of cell proliferation;multicellular organismal process;tube morphogenesis;regulation of body fluid levels;cell proliferation;regulation of extracellular matrix organization;cellular process;regulation of cell growth;branching morphogenesis of an epithelial tube;epithelial tube morphogenesis;mammary gland alveolus development;movement of cell or subcellular component;localization of cell;epiboly;embryo implantation;regulation of cell-matrix adhesion;macromolecule metabolic process;morphogenesis of a branching structure;system development;gland development;regulation of extracellular matrix disassembly;mammary gland epithelium development;epiboly involved in wound healing;peptidyl-tyrosine phosphorylation;smooth muscle cell migration;multicellular organism development;morphogenesis of an epithelium;organic substance metabolic process;ear development;tissue morphogenesis;skin development;protein phosphorylation;epithelium development;body fluid secretion;regulation of cell-substrate adhesion;cellular protein modification process;single-organism developmental process;reproductive process;single-organism transport;single-organism cellular process;cell adhesion;cell communication;tube development;localization;single-organism localization;growth;locomotion;primary metabolic process;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of growth;negative regulation of cellular process; 6;5;5;5;4;5;6;7;2;3;8;4;7;4;2;4;4;4;5;3;6;2;3;3;4;3;3;4;3;5;5;4;7;6;4;5;2;5;3;4;5;3;2;3;5;4;4;4;5;3;5;5;1;6;2;3;2;5;4;2;3;4;6;4;4;2;3;8;2;9;4;6;6;5;4;2;2;4;2;4;4;3;5;2;4;5;5;4;4;3;7;4;6;4;4;4;4;6;6;6;8;6;4;5;3;5;4;5;7;5;5;5;6;3;2;4;3;3;4;4;2;3;2;2;3;3;3;5;4;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0098589;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0098590;GO:0043227;GO:0043235;GO:0031224;GO:0071944;GO:0031226;GO:0044459;GO:0016323;GO:0070062;GO:0044464;GO:0005623;GO:0005615;GO:0098805;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;membrane region;protein complex;extracellular organelle;membrane part;extracellular region part;plasma membrane region;membrane-bounded organelle;receptor complex;intrinsic component of membrane;cell periphery;intrinsic component of plasma membrane;plasma membrane part;basolateral plasma membrane;extracellular exosome;cell part;cell;extracellular space;whole membrane;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 4;4;2;3;3;3;2;2;4;3;4;3;3;4;3;4;4;2;2;3;3;2;4;3;3;2;1;2; GO:0060089;GO:1901363;GO:0000166;GO:0016740;GO:0004713;GO:0046872;GO:0097367;GO:0099600;GO:0038062;GO:0038064;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016301;GO:0003824;GO:0036094;GO:0016773;GO:0016772;GO:0044877;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0043169;GO:0004714;GO:0043167;GO:0032403;GO:0030554;GO:0005515;GO:0097159;GO:0005518;GO:0038023;GO:0004872;GO:0004871;GO:0001883;GO:0001882;GO:0004888;GO:0004672;GO:0019199; molecular transducer activity;heterocyclic compound binding;nucleotide binding;transferase activity;protein tyrosine kinase activity;metal ion binding;carbohydrate derivative binding;transmembrane receptor activity;protein tyrosine kinase collagen receptor activity;collagen receptor activity;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;kinase activity;catalytic activity;small molecule binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;macromolecular complex binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;cation binding;transmembrane receptor protein tyrosine kinase activity;ion binding;protein complex binding;adenyl nucleotide binding;protein binding;organic cyclic compound binding;collagen binding;signaling receptor activity;receptor activity;signal transducer activity;purine nucleoside binding;nucleoside binding;transmembrane signaling receptor activity;protein kinase activity;transmembrane receptor protein kinase activity; 2;3;4;3;7;5;3;4;6;5;1;2;4;5;5;6;5;2;3;5;4;3;6;5;6;4;5;4;4;6;3;4;6;3;3;5;3;3;2;5;4;4;6;5; K05124 IPR011009;IPR002011;IPR000719;IPR008266;IPR001245;IPR000421;IPR008979;IPR020635;IPR029553; Protein kinase-like domain;Tyrosine-protein kinase, receptor class II, conserved site;Protein kinase domain;Tyrosine-protein kinase, active site;Serine-threonine/tyrosine-protein kinase, catalytic domain;Coagulation factor 5/8 C-terminal domain;Galactose-binding domain-like;Tyrosine-protein kinase, catalytic domain;Epithelial discoidin domain-containing receptor 1; extracellular Hs7669483 1820.0 T [T] Signal transduction mechanisms; P78395 Melanoma antigen preferentially expressed in tumors OS=Homo sapiens OX=9606 GN=PRAME PE=1 SV=1 - [PRAME_HUMAN] 0.931 1.224 0.824 1.056 1.31 0.684 0.760620915 nan 0.80610687 nan 0.673202614 nan 0.522137405 nan GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0007165;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0048869;GO:0010467;GO:0048518;GO:0048519;GO:0042127;GO:0060255;GO:0060548;GO:2001141;GO:0046483;GO:0044700;GO:0023057;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0043170;GO:0042981;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0048387;GO:0018130;GO:0050793;GO:0009889;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:1902679;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0048385;GO:0048384;GO:0044699;GO:0006139;GO:0008284;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045596;GO:0045595;GO:0045892;GO:0051093;GO:0051253;GO:0051252;GO:0010629;GO:0032502;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0008219;GO:0010941;GO:0030522;GO:0040007;GO:0040008;GO:2000112;GO:2000113;GO:0071704;GO:0043067;GO:0043066;GO:0043069;GO:0010468;GO:0045934;GO:0019219;GO:0006915;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007154;GO:0044238;GO:0044237;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;gene expression;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;negative regulation of cell death;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;negative regulation of signaling;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of apoptotic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;negative regulation of retinoic acid receptor signaling pathway;heterocycle biosynthetic process;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;programmed cell death;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;regulation of retinoic acid receptor signaling pathway;retinoic acid receptor signaling pathway;single-organism process;nucleobase-containing compound metabolic process;positive regulation of cell proliferation;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;negative regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;developmental process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell death;regulation of cell death;intracellular receptor signaling pathway;growth;regulation of growth;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell communication;primary metabolic process;cellular metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;3;4;5;4;3;4;4;4;4;5;2;2;4;4;4;6;4;3;3;5;3;4;3;4;6;2;7;4;4;2;5;5;3;4;3;5;1;2;5;5;6;5;2;6;5;6;5;6;5;4;4;2;4;5;3;4;5;6;2;4;4;3;2;4;7;7;4;4;6;3;5;5;5;2;5;5;4;4;5;4;4;5;2;3;6;6;3;5;6;5;5;5;5;6;3;3;5;3;4;4;4;3;3;3;3; GO:0016020;GO:0043231;GO:0044424;GO:0043229;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0043227;GO:0043226;GO:0005886;GO:0005575; membrane;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;nucleus;cell part;cell;intracellular;cell periphery;membrane-bounded organelle;organelle;plasma membrane;cellular_component; 2;4;3;3;5;2;2;3;3;3;2;3;1; GO:0003674;GO:0005488;GO:0035257;GO:0008134;GO:0051427;GO:0005515;GO:0005102;GO:0042974; molecular_function;binding;nuclear hormone receptor binding;transcription factor binding;hormone receptor binding;protein binding;receptor binding;retinoic acid receptor binding; 1;2;6;4;5;3;4;5; IPR026271;IPR032675; PRAME family;Leucine-rich repeat domain, L domain-like; nucleus Q15643 Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3 - [TRIPB_HUMAN] 1.061 1.192 0.699 1.488 1.005 0.67 0.890100671 nan 1.480597015 nan 0.586409396 nan 0.666666667 nan GO:0008104;GO:0080090;GO:0019222;GO:0072359;GO:0072358;GO:1901362;GO:0071840;GO:0070727;GO:0048513;GO:0033036;GO:0060255;GO:0006605;GO:0045184;GO:2001141;GO:0046483;GO:0044707;GO:0019438;GO:0034067;GO:0003281;GO:0006807;GO:0097659;GO:0003205;GO:1901576;GO:0044260;GO:0006886;GO:0016043;GO:0065007;GO:1901360;GO:0018130;GO:0006810;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0003231;GO:0051234;GO:0016070;GO:0006891;GO:0044271;GO:0046907;GO:0044765;GO:0072594;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0000042;GO:0032502;GO:0032501;GO:0007507;GO:0000301;GO:0009987;GO:0006725;GO:1903506;GO:0072600;GO:0051252;GO:0043170;GO:0033365;GO:0048731;GO:0031326;GO:0031323;GO:0006366;GO:0090304;GO:0007275;GO:0050789;GO:0071704;GO:0010467;GO:0071702;GO:0048193;GO:0019219;GO:0034613;GO:0044767;GO:0009058;GO:0009059;GO:0051171;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0003279;GO:0048856;GO:0044237;GO:0015031;GO:1902582;GO:1902580;GO:0016192; protein localization;regulation of primary metabolic process;regulation of metabolic process;circulatory system development;cardiovascular system development;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular macromolecule localization;animal organ development;macromolecule localization;regulation of macromolecule metabolic process;protein targeting;establishment of protein localization;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;protein localization to Golgi apparatus;ventricular septum development;nitrogen compound metabolic process;nucleic acid-templated transcription;cardiac chamber development;organic substance biosynthetic process;cellular macromolecule metabolic process;intracellular protein transport;cellular component organization;biological regulation;organic cyclic compound metabolic process;heterocycle biosynthetic process;transport;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;cardiac ventricle development;establishment of localization;RNA metabolic process;intra-Golgi vesicle-mediated transport;cellular nitrogen compound biosynthetic process;intracellular transport;single-organism transport;establishment of protein localization to organelle;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;protein targeting to Golgi;developmental process;multicellular organismal process;heart development;retrograde transport, vesicle recycling within Golgi;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;establishment of protein localization to Golgi;regulation of RNA metabolic process;macromolecule metabolic process;protein localization to organelle;system development;regulation of cellular biosynthetic process;regulation of cellular metabolic process;transcription from RNA polymerase II promoter;nucleic acid metabolic process;multicellular organism development;regulation of biological process;organic substance metabolic process;gene expression;organic substance transport;Golgi vesicle transport;regulation of nucleobase-containing compound metabolic process;cellular protein localization;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;cardiac septum development;anatomical structure development;cellular metabolic process;protein transport;single-organism intracellular transport;single-organism cellular localization;vesicle-mediated transport; 4;4;3;5;5;5;2;4;4;3;4;6;4;6;4;3;5;7;5;3;7;4;4;4;6;3;2;4;5;4;4;3;1;2;5;5;3;5;7;5;5;4;5;5;6;6;4;4;5;2;4;5;2;2;4;8;2;4;7;6;5;4;6;4;5;4;7;5;4;2;3;5;5;6;5;5;3;3;5;4;4;2;3;3;4;3;4;3;3;5;5;4;5; GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0012506;GO:0005794;GO:0099503;GO:0098588;GO:0098589;GO:0043231;GO:0002079;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044433;GO:0044431;GO:0030141;GO:0012505;GO:0044425;GO:0000139;GO:0044446;GO:0044444;GO:0097708;GO:0001669;GO:0005737;GO:0030667;GO:0031090;GO:0031410;GO:0005634;GO:0097223;GO:0030659;GO:0002080;GO:0044464;GO:0005623;GO:0043228;GO:0002081;GO:0098805;GO:0005856;GO:0005801;GO:0005575; vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;vesicle membrane;Golgi apparatus;secretory vesicle;bounding membrane of organelle;membrane region;intracellular membrane-bounded organelle;inner acrosomal membrane;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasmic vesicle part;Golgi apparatus part;secretory granule;endomembrane system;membrane part;Golgi membrane;intracellular organelle part;cytoplasmic part;intracellular vesicle;acrosomal vesicle;cytoplasm;secretory granule membrane;organelle membrane;cytoplasmic vesicle;nucleus;sperm part;cytoplasmic vesicle membrane;acrosomal membrane;cell part;cell;non-membrane-bounded organelle;outer acrosomal membrane;whole membrane;cytoskeleton;cis-Golgi network;cellular_component; 4;5;2;5;4;4;6;4;3;4;4;3;2;4;3;3;3;2;4;4;4;3;2;5;3;4;4;4;4;4;3;5;5;3;5;4;2;2;3;4;3;5;5;1; GO:0003713;GO:0003712;GO:0003674;GO:0000989;GO:0000988; transcription coactivator activity;transcription cofactor activity;molecular_function;transcription factor activity, transcription factor binding;transcription factor activity, protein binding; 5;4;1;3;2; K23368 IPR000237; GRIP domain; nucleus Q8IXQ6 Protein mono-ADP-ribosyltransferase PARP9 OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2 - [PARP9_HUMAN] 0.884 0.949 0.983 0.95 0.911 2.668 0.931506849 0.7028368 1.042810099 0.561148008 1.035827187 0.91690661 2.928649835 0.001447976 GO:0060330;GO:0002376;GO:0048870;GO:0048583;GO:0006928;GO:0090304;GO:0080134;GO:0034641;GO:0006807;GO:0044237;GO:0016477;GO:0051179;GO:0043170;GO:1901360;GO:0034097;GO:0006139;GO:0051716;GO:0006302;GO:0044260;GO:0050789;GO:0071704;GO:0002682;GO:0044699;GO:0065007;GO:0006952;GO:0045088;GO:0006281;GO:0045087;GO:0009987;GO:0006725;GO:0044710;GO:0034341;GO:0006974;GO:0006259;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0042221;GO:0031347;GO:0010033;GO:0046483;GO:0040011;GO:0044238;GO:0050776;GO:0050896;GO:0051674;GO:0033554;GO:0044763;GO:0060759; regulation of response to interferon-gamma;immune system process;cell motility;regulation of response to stimulus;movement of cell or subcellular component;nucleic acid metabolic process;regulation of response to stress;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;cell migration;localization;macromolecule metabolic process;organic cyclic compound metabolic process;response to cytokine;nucleobase-containing compound metabolic process;cellular response to stimulus;double-strand break repair;cellular macromolecule metabolic process;regulation of biological process;organic substance metabolic process;regulation of immune system process;single-organism process;biological regulation;defense response;regulation of innate immune response;DNA repair;innate immune response;cellular process;cellular aromatic compound metabolic process;single-organism metabolic process;response to interferon-gamma;cellular response to DNA damage stimulus;DNA metabolic process;response to stress;biological_process;metabolic process;immune response;response to chemical;regulation of defense response;response to organic substance;heterocycle metabolic process;locomotion;primary metabolic process;regulation of immune response;response to stimulus;localization of cell;cellular response to stress;single-organism cellular process;regulation of response to cytokine stimulus; 5;2;3;3;4;5;4;4;3;3;4;2;4;4;5;4;3;5;4;2;3;3;2;2;4;5;4;4;2;4;3;5;5;5;3;1;2;3;3;5;4;4;2;3;4;2;3;4;3;4; GO:0031974;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0016020;GO:0005739;GO:0005654;GO:0044446;GO:0043231;GO:0043233;GO:0031981;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0005829;GO:0044422; membrane-enclosed lumen;membrane-bounded organelle;organelle;cytoplasm;nucleus;membrane;mitochondrion;nucleoplasm;intracellular organelle part;intracellular membrane-bounded organelle;organelle lumen;nuclear lumen;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;cytosol;organelle part; 2;3;2;4;5;2;5;5;3;4;3;5;2;3;2;3;1;4;4;4;3;5;2; GO:0003674;GO:0003950;GO:0003824;GO:0016740;GO:0016763;GO:0016757; molecular_function;NAD+ ADP-ribosyltransferase activity;catalytic activity;transferase activity;transferase activity, transferring pentosyl groups;transferase activity, transferring glycosyl groups; 1;6;2;3;5;4; K15260 IPR034400;IPR012317;IPR002589; Poly [ADP-ribose] polymerase 9;Poly(ADP-ribose) polymerase, catalytic domain;Macro domain; cytosol Hs13899297_1 1365.0 BK [B] Chromatin structure and dynamics;[K] Transcription; Q09428 ATP-binding cassette sub-family C member 8 OS=Homo sapiens OX=9606 GN=ABCC8 PE=1 SV=6 - [ABCC8_HUMAN] 1.087 0.958 0.842 0.924 1.195 1.604 1.134655532 0.006520786 0.773221757 0.000145299 0.878914405 0.017203318 1.342259414 0.006116212 GO:0090087;GO:0008104;GO:0051046;GO:0051048;GO:0051049;GO:0044710;GO:0044281;GO:0010043;GO:0051716;GO:0043207;GO:0051707;GO:0009617;GO:0046879;GO:0048518;GO:0048519;GO:0033036;GO:1903530;GO:0051051;GO:0051050;GO:0045184;GO:0090276;GO:0010038;GO:0043434;GO:0010035;GO:0090278;GO:0010033;GO:0055114;GO:0051704;GO:0044700;GO:0009607;GO:0009605;GO:0010243;GO:0098916;GO:0023052;GO:0010648;GO:0042493;GO:0032940;GO:0032496;GO:0051223;GO:0051224;GO:0050789;GO:0030072;GO:0030073;GO:0050708;GO:0050709;GO:0006813;GO:0065007;GO:0098662;GO:0098660;GO:0065008;GO:0070201;GO:0009306;GO:0006812;GO:0006811;GO:0006810;GO:0050796;GO:0050794;GO:0008150;GO:0008152;GO:0009268;GO:0051234;GO:0046903;GO:0015980;GO:0050896;GO:0099536;GO:0099537;GO:0023057;GO:0015833;GO:1903531;GO:0046676;GO:0070887;GO:0023051;GO:1904950;GO:0010646;GO:0044699;GO:0032880;GO:0009719;GO:0042886;GO:0071804;GO:0071805;GO:0015672;GO:0006112;GO:0043270;GO:0046883;GO:0030001;GO:0046888;GO:0032879;GO:0055085;GO:0042221;GO:0009725;GO:0002237;GO:1901698;GO:0060341;GO:1990267;GO:0043266;GO:0032868;GO:0006091;GO:0043269;GO:0043268;GO:0033993;GO:0071705;GO:0071310;GO:0071702;GO:0009987;GO:0023061;GO:0010817;GO:0010959;GO:0034220;GO:0044765;GO:0044763;GO:0007268;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:1901700;GO:0009628;GO:0002790;GO:0002791;GO:0002792;GO:0044237;GO:0009914;GO:1901652;GO:0015031;GO:0098655;GO:0048523; regulation of peptide transport;protein localization;regulation of secretion;negative regulation of secretion;regulation of transport;single-organism metabolic process;small molecule metabolic process;response to zinc ion;cellular response to stimulus;response to external biotic stimulus;response to other organism;response to bacterium;hormone secretion;positive regulation of biological process;negative regulation of biological process;macromolecule localization;regulation of secretion by cell;negative regulation of transport;positive regulation of transport;establishment of protein localization;regulation of peptide hormone secretion;response to metal ion;response to peptide hormone;response to inorganic substance;negative regulation of peptide hormone secretion;response to organic substance;oxidation-reduction process;multi-organism process;single organism signaling;response to biotic stimulus;response to external stimulus;response to organonitrogen compound;anterograde trans-synaptic signaling;signaling;negative regulation of cell communication;response to drug;secretion by cell;response to lipopolysaccharide;regulation of protein transport;negative regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;regulation of protein secretion;negative regulation of protein secretion;potassium ion transport;biological regulation;inorganic cation transmembrane transport;inorganic ion transmembrane transport;regulation of biological quality;regulation of establishment of protein localization;protein secretion;cation transport;ion transport;transport;regulation of insulin secretion;regulation of cellular process;biological_process;metabolic process;response to pH;establishment of localization;secretion;energy derivation by oxidation of organic compounds;response to stimulus;synaptic signaling;trans-synaptic signaling;negative regulation of signaling;peptide transport;negative regulation of secretion by cell;negative regulation of insulin secretion;cellular response to chemical stimulus;regulation of signaling;negative regulation of establishment of protein localization;regulation of cell communication;single-organism process;regulation of protein localization;response to endogenous stimulus;amide transport;cellular potassium ion transport;potassium ion transmembrane transport;monovalent inorganic cation transport;energy reserve metabolic process;positive regulation of ion transport;regulation of hormone secretion;metal ion transport;negative regulation of hormone secretion;regulation of localization;transmembrane transport;response to chemical;response to hormone;response to molecule of bacterial origin;response to nitrogen compound;regulation of cellular localization;response to transition metal nanoparticle;regulation of potassium ion transport;response to insulin;generation of precursor metabolites and energy;regulation of ion transport;positive regulation of potassium ion transport;response to lipid;nitrogen compound transport;cellular response to organic substance;organic substance transport;cellular process;signal release;regulation of hormone levels;regulation of metal ion transport;ion transmembrane transport;single-organism transport;single-organism cellular process;synaptic transmission;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;response to oxygen-containing compound;response to abiotic stimulus;peptide secretion;regulation of peptide secretion;negative regulation of peptide secretion;cellular metabolic process;hormone transport;response to peptide;protein transport;cation transmembrane transport;negative regulation of cellular process; 5;4;5;4;4;3;4;5;3;4;3;4;6;2;2;3;5;3;3;4;5;5;5;4;5;4;4;2;3;3;3;4;7;2;4;4;4;5;5;4;2;7;6;6;5;8;2;7;6;3;5;5;6;5;4;6;3;1;2;4;3;5;4;2;5;6;3;6;4;6;4;3;3;4;2;4;3;5;4;5;7;5;4;4;7;4;3;4;3;4;5;4;4;4;7;6;4;5;5;5;5;5;5;2;5;4;6;5;4;3;8;4;4;2;3;3;4;3;6;6;5;3;5;5;5;6;3; GO:0031224;GO:0070382;GO:0031982;GO:0016023;GO:0016021;GO:1902495;GO:0098588;GO:0008076;GO:0043234;GO:0043231;GO:0044424;GO:0034705;GO:0044433;GO:0042383;GO:1990351;GO:0099501;GO:0097708;GO:0044425;GO:0030672;GO:0044444;GO:0044422;GO:0031410;GO:0031988;GO:0008021;GO:0016020;GO:0012505;GO:0012506;GO:0005886;GO:0045202;GO:0031226;GO:0031090;GO:0005737;GO:0044456;GO:0044459;GO:0030659;GO:0043227;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0034702;GO:0034703;GO:0030658;GO:0071944;GO:0030133;GO:0098797;GO:0099503;GO:0098805;GO:0043226;GO:0097458;GO:0098793;GO:0044446;GO:0005887;GO:0032991;GO:0005575;GO:0098796; intrinsic component of membrane;exocytic vesicle;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;transmembrane transporter complex;bounding membrane of organelle;voltage-gated potassium channel complex;protein complex;intracellular membrane-bounded organelle;intracellular part;potassium channel complex;cytoplasmic vesicle part;sarcolemma;transporter complex;exocytic vesicle membrane;intracellular vesicle;membrane part;synaptic vesicle membrane;cytoplasmic part;organelle part;cytoplasmic vesicle;membrane-bounded vesicle;synaptic vesicle;membrane;endomembrane system;vesicle membrane;plasma membrane;synapse;intrinsic component of plasma membrane;organelle membrane;cytoplasm;synapse part;plasma membrane part;cytoplasmic vesicle membrane;membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;ion channel complex;cation channel complex;transport vesicle membrane;cell periphery;transport vesicle;plasma membrane protein complex;secretory vesicle;whole membrane;organelle;neuron part;presynapse;intracellular organelle part;integral component of plasma membrane;macromolecular complex;cellular_component;membrane protein complex; 3;5;4;5;4;4;4;5;3;4;3;7;4;4;4;5;4;2;3;4;2;5;5;3;2;3;4;3;2;4;3;4;2;3;5;3;2;3;2;3;5;6;4;3;4;4;6;3;2;3;3;3;4;2;1;3; GO:0005267;GO:0005261;GO:0060089;GO:0001883;GO:0044325;GO:1901363;GO:0015399;GO:0000166;GO:0046873;GO:0032549;GO:0017076;GO:0016818;GO:0097367;GO:0016817;GO:0005524;GO:0015405;GO:0099600;GO:0003674;GO:0005488;GO:0016887;GO:0042626;GO:0042623;GO:0022803;GO:0022804;GO:0016787;GO:0003824;GO:0022891;GO:0022890;GO:0022892;GO:0097159;GO:0015075;GO:0016462;GO:0015077;GO:0015267;GO:0032559;GO:0032555;GO:0015079;GO:0032550;GO:0035639;GO:0043168;GO:0016820;GO:0043492;GO:0043167;GO:0008281;GO:0005215;GO:0005216;GO:0008324;GO:0030554;GO:0005515;GO:0022838;GO:0038023;GO:0036094;GO:0004872;GO:0004871;GO:0004888;GO:1901265;GO:0001882;GO:0017111;GO:0022857;GO:0032553; potassium channel activity;cation channel activity;molecular transducer activity;purine nucleoside binding;ion channel binding;heterocyclic compound binding;primary active transmembrane transporter activity;nucleotide binding;metal ion transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;ATP binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;transmembrane receptor activity;molecular_function;binding;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;passive transmembrane transporter activity;active transmembrane transporter activity;hydrolase activity;catalytic activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;organic cyclic compound binding;ion transmembrane transporter activity;pyrophosphatase activity;monovalent inorganic cation transmembrane transporter activity;channel activity;adenyl ribonucleotide binding;purine ribonucleotide binding;potassium ion transmembrane transporter activity;purine ribonucleoside binding;purine ribonucleoside triphosphate binding;anion binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ATPase activity, coupled to movement of substances;ion binding;sulfonylurea receptor activity;transporter activity;ion channel activity;cation transmembrane transporter activity;adenyl nucleotide binding;protein binding;substrate-specific channel activity;signaling receptor activity;small molecule binding;receptor activity;signal transducer activity;transmembrane signaling receptor activity;nucleoside phosphate binding;nucleoside binding;nucleoside-triphosphatase activity;transmembrane transporter activity;ribonucleotide binding; 8;7;2;5;4;3;5;4;8;5;5;5;3;4;6;6;4;1;2;8;6;9;4;4;3;2;4;7;3;3;5;6;8;5;6;5;9;6;5;4;5;10;3;5;2;6;6;6;3;5;3;3;3;2;4;4;4;7;3;4; K05032 map02010;map04911;map04930; ABC transporters;Insulin secretion;Type II diabetes mellitus; IPR000844;IPR003593;IPR017871;IPR003439;IPR011527;IPR000388;IPR027417; ATP-binding cassette subfamily C member 8;AAA+ ATPase domain;ABC transporter, conserved site;ABC transporter-like;ABC transporter type 1, transmembrane domain;Sulphonylurea receptor;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Hs4507317 3244.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q9Y6Y1 Calmodulin-binding transcription activator 1 OS=Homo sapiens OX=9606 GN=CAMTA1 PE=1 SV=4 - [CMTA1_HUMAN] 1.051 1.589 0.849 0.905 0.844 0.946 0.661422278 nan 1.072274882 nan 0.534298301 nan 1.120853081 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010604;GO:0048518;GO:0003008;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0010628;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0050885;GO:1903508;GO:0032501;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0006807;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0050905;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;system process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of gene expression;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;neuromuscular process controlling balance;positive regulation of nucleic acid-templated transcription;multicellular organismal process;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;neuromuscular process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;2;3;4;6;4;5;3;4;5;2;7;4;4;2;7;5;4;3;1;2;5;5;5;6;5;7;6;6;4;4;5;4;6;7;2;4;2;4;7;6;5;5;4;6;3;7;5;5;4;4;5;5;6;3;5;5;5;5;5;3;5;4;4;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasm;nucleus;cell part;cell;organelle;cellular_component; 4;3;3;3;3;4;5;2;2;2;1; GO:0001077;GO:0001071;GO:1901363;GO:0001228;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000982;GO:0000981;GO:0043565;GO:0097159;GO:0003700; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription factor activity, sequence-specific DNA binding; 6;2;3;5;1;2;4;5;5;4;6;3;3; K21596 IPR002909;IPR002110;IPR000048;IPR020683;IPR013783;IPR014756;IPR005559;IPR027417; IPT domain;Ankyrin repeat;IQ motif, EF-hand binding site;Ankyrin repeat-containing domain;Immunoglobulin-like fold;Immunoglobulin E-set;CG-1 DNA-binding domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs22041855 3484.0 S [S] Function unknown; A0A0B4J1V1 Immunoglobulin heavy variable 3-21 OS=Homo sapiens OX=9606 GN=IGHV3-21 PE=1 SV=1 - [HV321_HUMAN] 1.092 1.042 0.718 1.232 1.1 1.251 1.047984645 0.668057908 1.12 0.571181449 0.689059501 0.174346562 1.137272727 0.526994419 IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular A0A0B4J1V0 Immunoglobulin heavy variable 3-15 OS=Homo sapiens OX=9606 GN=IGHV3-15 PE=3 SV=1 - [HV315_HUMAN] 1.05 1.125 0.88 0.975 1.11 0.6 0.933333333 0.443487603 0.878378378 0.119922154 0.782222222 0.031772521 0.540540541 0.001860852 IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P07360 Complement component C8 gamma chain OS=Homo sapiens OX=9606 GN=C8G PE=1 SV=3 - [CO8G_HUMAN] 1.038 0.896 1.149 1 0.847 1.141 1.158482143 0.026793894 1.180637544 0.105346231 1.282366071 8.23E-05 1.347107438 0.002186606 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:0019724;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0019835;GO:0002684;GO:0002682;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0006957;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0002697;GO:0006956;GO:1903317;GO:0008152;GO:0032101;GO:0009611;GO:0044699;GO:0002443;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0016485;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044238;GO:0002250;GO:0002253;GO:0002252; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;cytolysis;positive regulation of immune system process;regulation of immune system process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;complement activation, alternative pathway;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;regulation of immune effector process;complement activation;regulation of protein maturation;metabolic process;regulation of response to external stimulus;response to wounding;single-organism process;leukocyte mediated immunity;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;protein processing;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;primary metabolic process;adaptive immune response;activation of immune response;immune effector process; 4;3;3;3;5;5;3;5;2;2;6;4;4;6;6;3;4;2;5;5;2;3;3;3;4;3;7;1;5;5;3;6;5;4;7;5;2;4;4;6;2;4;4;2;4;5;5;5;2;6;4;5;4;4;4;3;3;5;5;4;5;3;4;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0072562;GO:0031224;GO:0031226;GO:0046930;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0098797;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0098796;GO:0005576;GO:0005579; vesicle;integral component of membrane;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;blood microparticle;intrinsic component of membrane;intrinsic component of plasma membrane;pore complex;plasma membrane part;cell part;cell;cell periphery;plasma membrane protein complex;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;membrane protein complex;extracellular region;membrane attack complex; 4;4;2;3;3;2;2;3;3;3;4;4;3;2;2;3;4;4;2;4;3;3;3;2;1;3;2;5; GO:0003674;GO:0005488;GO:0005501;GO:0008289;GO:0043178;GO:0036094;GO:0019840;GO:0019841;GO:0019842; molecular_function;binding;retinoid binding;lipid binding;alcohol binding;small molecule binding;isoprenoid binding;retinol binding;vitamin binding; 1;2;5;3;4;3;4;5;4; K03999 map04610;map05020;map05146;map05322; Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus; IPR000566;IPR002345;IPR002968;IPR012674;IPR022272; Lipocalin/cytosolic fatty-acid binding domain;Lipocalin;Alpha-1-microglobulin;Calycin;Lipocalin family conserved site; extracellular A0A0B4J1V2 Immunoglobulin heavy variable 2-26 OS=Homo sapiens OX=9606 GN=IGHV2-26 PE=3 SV=1 - [HV226_HUMAN] 0.955 1.285 0.73 0.827 1.481 0.684 0.743190661 0.00146217 0.558406482 0.05175749 0.568093385 0.067723163 0.461850101 0.036583409 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q8IXQ9 Electron transfer flavoprotein beta subunit lysine methyltransferase OS=Homo sapiens OX=9606 GN=ETFBKMT PE=1 SV=1 - [ETKMT_HUMAN] 0.89 0.99 1.293 0.959 1.067 0.763 0.898989899 nan 0.898781631 nan 1.306060606 nan 0.715089035 nan GO:0006479;GO:0034440;GO:0080090;GO:0019222;GO:0044281;GO:0044282;GO:0044712;GO:0044710;GO:0018193;GO:0045833;GO:0044092;GO:0048519;GO:0032787;GO:0072329;GO:0043436;GO:0055114;GO:0018205;GO:0016054;GO:0019538;GO:1904732;GO:1904733;GO:0009894;GO:0009895;GO:1904736;GO:0018023;GO:1904735;GO:0046320;GO:0046322;GO:0050789;GO:0044267;GO:1901575;GO:0044260;GO:0016042;GO:0065007;GO:0065009;GO:0032259;GO:0006629;GO:0050794;GO:0043412;GO:0036211;GO:0043414;GO:0008152;GO:0019395;GO:0046395;GO:0008150;GO:0006631;GO:0006635;GO:0044248;GO:0009892;GO:0044242;GO:0044699;GO:0018022;GO:0010565;GO:0031330;GO:0009987;GO:0044255;GO:0030258;GO:0006082;GO:0009062;GO:0043170;GO:0031999;GO:0045922;GO:0031329;GO:0031324;GO:0031323;GO:0019752;GO:0008213;GO:0071704;GO:0019217;GO:0019216;GO:0006464;GO:0044763;GO:0009056;GO:0044238;GO:0042180;GO:0031998;GO:0033539;GO:0050995;GO:0050994;GO:0044237;GO:0048523; protein methylation;lipid oxidation;regulation of primary metabolic process;regulation of metabolic process;small molecule metabolic process;small molecule catabolic process;single-organism catabolic process;single-organism metabolic process;peptidyl-amino acid modification;negative regulation of lipid metabolic process;negative regulation of molecular function;negative regulation of biological process;monocarboxylic acid metabolic process;monocarboxylic acid catabolic process;oxoacid metabolic process;oxidation-reduction process;peptidyl-lysine modification;organic acid catabolic process;protein metabolic process;regulation of electron carrier activity;negative regulation of electron carrier activity;regulation of catabolic process;negative regulation of catabolic process;negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase;peptidyl-lysine trimethylation;regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase;regulation of fatty acid oxidation;negative regulation of fatty acid oxidation;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;lipid catabolic process;biological regulation;regulation of molecular function;methylation;lipid metabolic process;regulation of cellular process;macromolecule modification;protein modification process;macromolecule methylation;metabolic process;fatty acid oxidation;carboxylic acid catabolic process;biological_process;fatty acid metabolic process;fatty acid beta-oxidation;cellular catabolic process;negative regulation of metabolic process;cellular lipid catabolic process;single-organism process;peptidyl-lysine methylation;regulation of cellular ketone metabolic process;negative regulation of cellular catabolic process;cellular process;cellular lipid metabolic process;lipid modification;organic acid metabolic process;fatty acid catabolic process;macromolecule metabolic process;negative regulation of fatty acid beta-oxidation;negative regulation of fatty acid metabolic process;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;protein alkylation;organic substance metabolic process;regulation of fatty acid metabolic process;regulation of lipid metabolic process;cellular protein modification process;single-organism cellular process;catabolic process;primary metabolic process;cellular ketone metabolic process;regulation of fatty acid beta-oxidation;fatty acid beta-oxidation using acyl-CoA dehydrogenase;negative regulation of lipid catabolic process;regulation of lipid catabolic process;cellular metabolic process;negative regulation of cellular process; 5;5;4;3;4;5;4;3;7;4;4;2;7;7;5;4;8;5;4;4;5;4;4;7;7;7;7;6;2;5;4;4;5;2;3;3;4;3;5;5;4;2;6;6;1;5;7;4;3;5;2;6;5;5;2;4;5;4;6;4;6;5;5;4;4;6;7;3;6;5;6;3;3;3;4;6;8;5;5;3;3; GO:0031974;GO:0043231;GO:0043233;GO:0044429;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044446;GO:0044444;GO:0005737;GO:0005739;GO:0044464;GO:0005623;GO:0043226;GO:0005759;GO:0005575;GO:0070013; membrane-enclosed lumen;intracellular membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;intracellular organelle part;cytoplasmic part;cytoplasm;mitochondrion;cell part;cell;organelle;mitochondrial matrix;cellular_component;intracellular organelle lumen; 2;4;3;4;3;2;3;3;3;3;4;4;5;2;2;2;5;1;4; GO:0008276;GO:0016740;GO:0008170;GO:0016278;GO:0016279;GO:0003674;GO:0008168;GO:0003824;GO:0016741;GO:0008757; protein methyltransferase activity;transferase activity;N-methyltransferase activity;lysine N-methyltransferase activity;protein-lysine N-methyltransferase activity;molecular_function;methyltransferase activity;catalytic activity;transferase activity, transferring one-carbon groups;S-adenosylmethionine-dependent methyltransferase activity; 6;3;6;7;7;1;5;2;4;6; K22843 IPR029063; S-adenosyl-L-methionine-dependent methyltransferase; mitochondria 154251096 138.0 R [R] General function prediction only; COG3897 Predicted nicotinamide N-methyase O15417 Trinucleotide repeat-containing gene 18 protein OS=Homo sapiens OX=9606 GN=TNRC18 PE=1 SV=3 - [TNC18_HUMAN] 0.733 1.029 1.311 1.02 1.164 0.637 0.71234208 nan 0.87628866 nan 1.274052478 nan 0.547250859 nan GO:0080090;GO:0019222;GO:1901362;GO:0071840;GO:0010605;GO:0040029;GO:0016458;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0031507;GO:0019438;GO:0016568;GO:0071103;GO:0022607;GO:0009892;GO:0034645;GO:0009890;GO:0010629;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0031497;GO:0044699;GO:0006139;GO:0006342;GO:0031327;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0006338;GO:0051253;GO:0051252;GO:0006333;GO:0043170;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0006325;GO:0070828;GO:2000112;GO:2000113;GO:0006323;GO:0071704;GO:0010467;GO:0045814;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0044085;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of macromolecule metabolic process;regulation of gene expression, epigenetic;gene silencing;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;heterochromatin assembly;aromatic compound biosynthetic process;chromatin modification;DNA conformation change;cellular component assembly;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;negative regulation of gene expression;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;chromatin assembly;single-organism process;nucleobase-containing compound metabolic process;chromatin silencing;negative regulation of cellular biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;chromatin remodeling;negative regulation of RNA metabolic process;regulation of RNA metabolic process;chromatin assembly or disassembly;macromolecule metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;heterochromatin organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;DNA packaging;organic substance metabolic process;gene expression;negative regulation of gene expression, epigenetic;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;cellular component biogenesis;negative regulation of cellular process; 4;3;5;2;4;6;4;2;4;6;4;7;5;6;6;4;3;5;4;5;3;2;7;4;4;3;5;2;4;5;4;3;1;2;5;5;5;6;5;6;5;6;4;4;6;2;4;5;5;2;4;7;7;6;7;5;5;6;4;4;5;4;4;5;5;6;6;6;7;3;5;6;5;5;5;6;3;5;3;4;4;4;3;5;3;3;3; GO:0031974;GO:0031975;GO:0005654;GO:0031981;GO:0016020;GO:0005677;GO:0031965;GO:0044422;GO:0031967;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0000785;GO:0005622;GO:0043227;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0005739;GO:0044464;GO:0005623;GO:0043228;GO:0043226;GO:0005694;GO:0043229;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;nucleoplasm;nuclear lumen;membrane;chromatin silencing complex;nuclear membrane;organelle part;organelle envelope;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;chromatin;intracellular;membrane-bounded organelle;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;nucleus;nuclear envelope;mitochondrion;cell part;cell;non-membrane-bounded organelle;organelle;chromosome;intracellular organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;5;5;2;4;4;2;4;3;4;4;3;4;3;4;3;3;3;3;3;4;4;3;5;4;5;2;2;3;2;5;3;2;1;4; GO:1901363;GO:0044877;GO:0044212;GO:0005488;GO:0003676;GO:0003677;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:1990837;GO:0003690;GO:0003674;GO:0003682;GO:0001067; heterocyclic compound binding;macromolecular complex binding;transcription regulatory region DNA binding;binding;nucleic acid binding;DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;molecular_function;chromatin binding;regulatory region nucleic acid binding; 3;3;7;2;4;5;6;3;8;6;7;6;1;4;5; IPR001025; Bromo adjacent homology (BAH) domain; nucleus Q9HCI7 E3 ubiquitin-protein ligase MSL2 OS=Homo sapiens OX=9606 GN=MSL2 PE=1 SV=2 - [MSL2_HUMAN] 0.735 1.097 1.1 0.956 1.48 0.37 0.670009116 nan 0.645945946 nan 1.002734731 nan 0.25 nan GO:0008152;GO:0043933;GO:0018205;GO:0006473;GO:0006475;GO:0044237;GO:0018193;GO:0071840;GO:0044710;GO:0032446;GO:0006325;GO:0043967;GO:0070647;GO:0016043;GO:0071704;GO:0016570;GO:0016573;GO:0044267;GO:0018394;GO:0018393;GO:0006996;GO:0043170;GO:0043543;GO:0009987;GO:0006464;GO:0044260;GO:0043412;GO:0036211;GO:0008150;GO:0016567;GO:0044238;GO:0044699;GO:0019538;GO:0051276;GO:1902589;GO:0016568;GO:0044763;GO:0043984;GO:0016569; metabolic process;macromolecular complex subunit organization;peptidyl-lysine modification;protein acetylation;internal protein amino acid acetylation;cellular metabolic process;peptidyl-amino acid modification;cellular component organization or biogenesis;single-organism metabolic process;protein modification by small protein conjugation;chromatin organization;histone H4 acetylation;protein modification by small protein conjugation or removal;cellular component organization;organic substance metabolic process;histone modification;histone acetylation;cellular protein metabolic process;peptidyl-lysine acetylation;internal peptidyl-lysine acetylation;organelle organization;macromolecule metabolic process;protein acylation;cellular process;cellular protein modification process;cellular macromolecule metabolic process;macromolecule modification;protein modification process;biological_process;protein ubiquitination;primary metabolic process;single-organism process;protein metabolic process;chromosome organization;single-organism organelle organization;chromatin modification;single-organism cellular process;histone H4-K16 acetylation;covalent chromatin modification; 2;4;8;8;9;3;7;2;3;8;5;6;7;3;3;4;5;5;9;10;4;4;7;2;6;4;5;5;1;9;3;2;4;5;4;6;3;7;7; GO:0072487;GO:0031248;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005575;GO:0000123;GO:0005634;GO:0005654;GO:0044451;GO:1902493;GO:1902494;GO:1990234;GO:0043231;GO:0043234;GO:0032991;GO:0031981;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; MSL complex;protein acetyltransferase complex;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cellular_component;histone acetyltransferase complex;nucleus;nucleoplasm;nucleoplasm part;acetyltransferase complex;catalytic complex;transferase complex;intracellular membrane-bounded organelle;protein complex;macromolecular complex;nuclear lumen;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 6;4;2;3;3;2;1;5;5;5;5;6;4;5;4;3;2;5;3;2;2;3;3;4;4;3;2; GO:0008270;GO:0046914;GO:0043169;GO:0003674;GO:0061659;GO:0019787;GO:0004842;GO:0043167;GO:0016740;GO:0046872;GO:0061630;GO:0003824;GO:0016874;GO:0005488; zinc ion binding;transition metal ion binding;cation binding;molecular_function;ubiquitin-like protein ligase activity;ubiquitin-like protein transferase activity;ubiquitin-protein transferase activity;ion binding;transferase activity;metal ion binding;ubiquitin protein ligase activity;catalytic activity;ligase activity;binding; 7;6;4;1;5;4;5;3;3;5;6;2;3;2; K13164 IPR032043;IPR032049;IPR001841;IPR033467;IPR013083; E3 ubiquitin-protein ligase Msl2, zinc RING finger;E3 ubiquitin-protein ligase Msl2, CXC domain;Zinc finger, RING-type;Tesmin/TSO1-like CXC domain;Zinc finger, RING/FYVE/PHD-type; extracellular O60312 Probable phospholipid-transporting ATPase VA OS=Homo sapiens OX=9606 GN=ATP10A PE=2 SV=2 - [AT10A_HUMAN] 1.127 1.046 0.841 0.749 1.205 1.7 1.077437859 nan 0.621576763 nan 0.804015296 nan 1.410788382 nan GO:0061024;GO:0006820;GO:0032989;GO:0071840;GO:0097035;GO:0048869;GO:0033036;GO:0015711;GO:0034204;GO:0008360;GO:0010876;GO:0022604;GO:0022603;GO:0015914;GO:0050789;GO:0000902;GO:0016043;GO:0065007;GO:0044699;GO:0065008;GO:0050793;GO:0006811;GO:0006810;GO:0050794;GO:0044802;GO:0051234;GO:0008150;GO:0045332;GO:0006869;GO:0051128;GO:0009653;GO:0032502;GO:0009987;GO:0055085;GO:0071702;GO:0044767;GO:0034220;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0048856;GO:0015748; membrane organization;anion transport;cellular component morphogenesis;cellular component organization or biogenesis;regulation of membrane lipid distribution;cellular developmental process;macromolecule localization;organic anion transport;lipid translocation;regulation of cell shape;lipid localization;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;phospholipid transport;regulation of biological process;cell morphogenesis;cellular component organization;biological regulation;single-organism process;regulation of biological quality;regulation of developmental process;ion transport;transport;regulation of cellular process;single-organism membrane organization;establishment of localization;biological_process;phospholipid translocation;lipid transport;regulation of cellular component organization;anatomical structure morphogenesis;developmental process;cellular process;transmembrane transport;organic substance transport;single-organism developmental process;ion transmembrane transport;single-organism transport;single-organism cellular process;localization;single-organism localization;anatomical structure development;organophosphate ester transport; 4;6;4;2;4;4;3;6;5;4;4;5;4;6;2;5;3;2;2;3;3;5;4;3;4;3;1;6;5;4;3;2;2;4;5;3;5;4;3;2;3;3;5; GO:0005783;GO:0005789;GO:0016021;GO:0016020;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0012505;GO:0044446;GO:0044444;GO:0042175;GO:0031224;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0043226;GO:0005886;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;endomembrane system;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;intrinsic component of membrane;cytoplasm;organelle membrane;cell part;cell;intracellular;cell periphery;organelle;plasma membrane;cellular_component; 4;3;4;2;4;4;3;2;2;3;3;4;3;3;4;3;3;4;3;2;2;3;3;2;3;1; GO:0004012;GO:1901363;GO:0005548;GO:0000166;GO:0005319;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0036094;GO:0022892;GO:0097159;GO:0043492;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043169;GO:0000287;GO:0043167;GO:0005215;GO:0046872;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0043168; phospholipid-translocating ATPase activity;heterocyclic compound binding;phospholipid transporter activity;nucleotide binding;lipid transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;small molecule binding;substrate-specific transporter activity;organic cyclic compound binding;ATPase activity, coupled to movement of substances;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;cation binding;magnesium ion binding;ion binding;transporter activity;metal ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;anion binding; 6;3;5;4;4;5;3;4;1;2;8;4;9;5;5;6;3;2;3;3;3;10;6;6;5;6;4;5;4;6;3;2;5;6;5;4;7;4; K01530 IPR030357;IPR008250;IPR023298;IPR023299;IPR023214;IPR018303;IPR006539;IPR032630;IPR032631;IPR001757; Probable phospholipid-transporting ATPase VA;P-type ATPase, A domain;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;HAD-like domain;P-type ATPase, phosphorylation site;P-type ATPase, subfamily IV;P-type ATPase, C-terminal;P-type ATPase, N-terminal;P-type ATPase; plasma membrane Hs14424433 3105.0 R [R] General function prediction only; Q2M2E5 Uncharacterized protein C5orf64 OS=Homo sapiens OX=9606 GN=C5orf64 PE=2 SV=2 - [CE064_HUMAN] 0.96 0.852 1.549 0.586 1.078 0.877 1.126760563 0.180147378 0.543599258 0.008069256 1.818075117 0.009986128 0.813543599 0.256243931 GO:0005575;GO:0005576; cellular_component;extracellular region; 1;2; mitochondria P09543 2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2 - [CN37_HUMAN] 0.862 0.919 1.836 0.857 0.643 0.582 0.937976061 nan 1.33281493 nan 1.997823721 nan 0.905132193 nan GO:0009214;GO:0046434;GO:0048468;GO:0009166;GO:0061024;GO:0060322;GO:0044281;GO:0044707;GO:1901360;GO:1901361;GO:0044712;GO:0044710;GO:0043207;GO:0048869;GO:0009617;GO:0048513;GO:0046483;GO:0044700;GO:0007610;GO:0006839;GO:0051707;GO:0010033;GO:0051704;GO:0044248;GO:0009607;GO:0009605;GO:0044708;GO:0044802;GO:0098916;GO:0019439;GO:0021762;GO:0007626;GO:0006807;GO:0031175;GO:0032496;GO:1901575;GO:0000904;GO:0000902;GO:0016043;GO:0065007;GO:0071840;GO:0019637;GO:0065008;GO:0007420;GO:0061564;GO:0006810;GO:0048709;GO:0042063;GO:0046700;GO:0008150;GO:0008152;GO:0048731;GO:0034655;GO:0051234;GO:0048856;GO:0046902;GO:0044270;GO:0046907;GO:0050896;GO:0048812;GO:1901292;GO:0044763;GO:0006753;GO:0007006;GO:0099536;GO:0099537;GO:0030154;GO:0034641;GO:0023052;GO:0010001;GO:0007154;GO:0007005;GO:0009653;GO:0044699;GO:0007417;GO:0006139;GO:0090559;GO:0051649;GO:0051179;GO:0051641;GO:0032502;GO:0006996;GO:0032501;GO:0030534;GO:0009987;GO:0006725;GO:0007409;GO:0055086;GO:0032990;GO:0007568;GO:0002237;GO:0000226;GO:0009187;GO:0030030;GO:0007275;GO:0033993;GO:0009636;GO:0006796;GO:0032989;GO:0071704;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044765;GO:0009117;GO:0007268;GO:0007267;GO:0042221;GO:0022008;GO:0009056;GO:0008344;GO:1902578;GO:1901700;GO:0044238;GO:0048699;GO:0007017;GO:0007010;GO:0048858;GO:0007399;GO:0048857;GO:0044237;GO:1902589;GO:0030900;GO:0030901;GO:0006793;GO:1902582; cyclic nucleotide catabolic process;organophosphate catabolic process;cell development;nucleotide catabolic process;membrane organization;head development;small molecule metabolic process;single-multicellular organism process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism catabolic process;single-organism metabolic process;response to external biotic stimulus;cellular developmental process;response to bacterium;animal organ development;heterocycle metabolic process;single organism signaling;behavior;mitochondrial transport;response to other organism;response to organic substance;multi-organism process;cellular catabolic process;response to biotic stimulus;response to external stimulus;single-organism behavior;single-organism membrane organization;anterograde trans-synaptic signaling;aromatic compound catabolic process;substantia nigra development;locomotory behavior;nitrogen compound metabolic process;neuron projection development;response to lipopolysaccharide;organic substance catabolic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;biological regulation;cellular component organization or biogenesis;organophosphate metabolic process;regulation of biological quality;brain development;axon development;transport;oligodendrocyte differentiation;gliogenesis;heterocycle catabolic process;biological_process;metabolic process;system development;nucleobase-containing compound catabolic process;establishment of localization;anatomical structure development;regulation of mitochondrial membrane permeability;cellular nitrogen compound catabolic process;intracellular transport;response to stimulus;neuron projection morphogenesis;nucleoside phosphate catabolic process;single-organism cellular process;nucleoside phosphate metabolic process;mitochondrial membrane organization;synaptic signaling;trans-synaptic signaling;cell differentiation;cellular nitrogen compound metabolic process;signaling;glial cell differentiation;cell communication;mitochondrion organization;anatomical structure morphogenesis;single-organism process;central nervous system development;nucleobase-containing compound metabolic process;regulation of membrane permeability;establishment of localization in cell;localization;cellular localization;developmental process;organelle organization;multicellular organismal process;adult behavior;cellular process;cellular aromatic compound metabolic process;axonogenesis;nucleobase-containing small molecule metabolic process;cell part morphogenesis;aging;response to molecule of bacterial origin;microtubule cytoskeleton organization;cyclic nucleotide metabolic process;cell projection organization;multicellular organism development;response to lipid;response to toxic substance;phosphate-containing compound metabolic process;cellular component morphogenesis;organic substance metabolic process;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism transport;nucleotide metabolic process;synaptic transmission;cell-cell signaling;response to chemical;neurogenesis;catabolic process;adult locomotory behavior;single-organism localization;response to oxygen-containing compound;primary metabolic process;generation of neurons;microtubule-based process;cytoskeleton organization;cell projection morphogenesis;nervous system development;neural nucleus development;cellular metabolic process;single-organism organelle organization;forebrain development;midbrain development;phosphorus metabolic process;single-organism intracellular transport; 7;5;4;6;4;4;4;3;4;5;4;3;4;4;4;4;4;3;2;6;3;4;2;4;3;3;3;4;7;5;5;3;3;5;5;4;5;5;3;2;2;4;3;4;6;4;6;7;5;1;2;4;5;3;3;5;5;5;2;6;5;3;5;5;5;6;5;4;2;6;4;5;3;2;5;4;4;4;2;3;2;4;2;4;2;4;7;4;5;4;5;5;7;4;4;5;4;5;4;3;5;6;6;3;4;6;8;4;3;6;3;4;3;4;3;7;4;5;5;5;4;3;4;4;4;4;5; GO:0031974;GO:0031975;GO:0099512;GO:0042470;GO:0031982;GO:0043209;GO:0031988;GO:0031968;GO:0048770;GO:0098588;GO:0031967;GO:0031966;GO:0043230;GO:0042995;GO:0043232;GO:0043233;GO:0005902;GO:0043231;GO:0098858;GO:0044429;GO:0044421;GO:0044422;GO:0019866;GO:0043229;GO:0043227;GO:0043226;GO:0005856;GO:0005654;GO:0044430;GO:0005886;GO:0048471;GO:0044428;GO:0097708;GO:0044446;GO:0016023;GO:0044444;GO:0016020;GO:0005874;GO:0005737;GO:0031090;GO:0031410;GO:0005634;GO:0005741;GO:0005739;GO:0031143;GO:0099513;GO:0044464;GO:0019867;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0043228;GO:0071944;GO:0044424;GO:0070062;GO:0098805;GO:0015630;GO:0035749;GO:0035748;GO:1903561;GO:0005615;GO:0031981;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;envelope;supramolecular fiber;melanosome;vesicle;myelin sheath;membrane-bounded vesicle;organelle outer membrane;pigment granule;bounding membrane of organelle;organelle envelope;mitochondrial membrane;extracellular organelle;cell projection;intracellular non-membrane-bounded organelle;organelle lumen;microvillus;intracellular membrane-bounded organelle;actin-based cell projection;mitochondrial part;extracellular region part;organelle part;organelle inner membrane;intracellular organelle;membrane-bounded organelle;organelle;cytoskeleton;nucleoplasm;cytoskeletal part;plasma membrane;perinuclear region of cytoplasm;nuclear part;intracellular vesicle;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;membrane;microtubule;cytoplasm;organelle membrane;cytoplasmic vesicle;nucleus;mitochondrial outer membrane;mitochondrion;pseudopodium;polymeric cytoskeletal fiber;cell part;outer membrane;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;non-membrane-bounded organelle;cell periphery;intracellular part;extracellular exosome;whole membrane;microtubule cytoskeleton;myelin sheath adaxonal region;myelin sheath abaxonal region;extracellular vesicle;extracellular space;nuclear lumen;cellular_component;intracellular organelle lumen;extracellular region; 2;3;2;7;4;3;5;4;6;4;4;4;3;3;4;3;5;4;4;4;2;2;4;3;3;2;5;5;4;3;5;4;4;3;5;4;2;4;4;3;5;5;5;5;4;3;2;3;2;3;5;5;3;3;3;4;3;6;3;3;3;3;5;1;4;2; GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0008081;GO:1901363;GO:0016787;GO:0000166;GO:0016788;GO:0003824;GO:0036094;GO:0097159;GO:0004112;GO:0004113;GO:0042578;GO:0030551;GO:0003723; molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;phosphoric diester hydrolase activity;heterocyclic compound binding;hydrolase activity;nucleotide binding;hydrolase activity, acting on ester bonds;catalytic activity;small molecule binding;organic cyclic compound binding;cyclic-nucleotide phosphodiesterase activity;2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;phosphoric ester hydrolase activity;cyclic nucleotide binding;RNA binding; 1;2;4;4;6;3;3;4;4;2;3;3;7;8;5;5;5; K01121 IPR008431;IPR009097;IPR027417; Cyclic nucleotide phosphodiesterase;Cyclic phosphodiesterase;P-loop containing nucleoside triphosphate hydrolase; mitochondria Hs14916481 867.0 L [L] Replication, recombination and repair; P28340 DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2 - [DPOD1_HUMAN] 1.221 0.738 1.023 1.152 1.124 0.763 1.654471545 nan 1.024911032 nan 1.386178862 nan 0.678825623 nan GO:0060249;GO:0042769;GO:0044281;GO:0055081;GO:1901362;GO:1901360;GO:0051716;GO:0044711;GO:0006301;GO:0006260;GO:0006261;GO:0019725;GO:0006287;GO:0006284;GO:0006283;GO:0006281;GO:0006289;GO:0046483;GO:0065008;GO:0006271;GO:0019985;GO:0048878;GO:0033554;GO:0019438;GO:0044786;GO:0006297;GO:0045005;GO:0006298;GO:0006807;GO:0070911;GO:0043170;GO:1901576;GO:0045004;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0071214;GO:0018130;GO:0000723;GO:0044710;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0055088;GO:0051606;GO:0050896;GO:0000731;GO:0071482;GO:0009314;GO:0050801;GO:0044249;GO:0034641;GO:0009411;GO:0009416;GO:0034645;GO:0034644;GO:0044699;GO:0006139;GO:0071478;GO:0033683;GO:0022616;GO:0006310;GO:0044238;GO:0009987;GO:0006725;GO:0006974;GO:0055089;GO:0010833;GO:0044271;GO:0042592;GO:0007049;GO:0071897;GO:0090304;GO:0090305;GO:0022402;GO:0033260;GO:0071704;GO:0000278;GO:0009058;GO:0009059;GO:0044763;GO:0000722;GO:0006996;GO:0009628;GO:0006312;GO:0051276;GO:0032201;GO:0032200;GO:0044237;GO:1902589;GO:0006259; anatomical structure homeostasis;DNA damage response, detection of DNA damage;small molecule metabolic process;anion homeostasis;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;single-organism biosynthetic process;postreplication repair;DNA replication;DNA-dependent DNA replication;cellular homeostasis;base-excision repair, gap-filling;base-excision repair;transcription-coupled nucleotide-excision repair;DNA repair;nucleotide-excision repair;heterocycle metabolic process;regulation of biological quality;DNA strand elongation involved in DNA replication;translesion synthesis;chemical homeostasis;cellular response to stress;aromatic compound biosynthetic process;cell cycle DNA replication;nucleotide-excision repair, DNA gap filling;DNA-dependent DNA replication maintenance of fidelity;mismatch repair;nitrogen compound metabolic process;global genome nucleotide-excision repair;macromolecule metabolic process;organic substance biosynthetic process;DNA replication proofreading;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;cellular response to abiotic stimulus;heterocycle biosynthetic process;telomere maintenance;single-organism metabolic process;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;lipid homeostasis;detection of stimulus;response to stimulus;DNA synthesis involved in DNA repair;cellular response to light stimulus;response to radiation;ion homeostasis;cellular biosynthetic process;cellular nitrogen compound metabolic process;response to UV;response to light stimulus;cellular macromolecule biosynthetic process;cellular response to UV;single-organism process;nucleobase-containing compound metabolic process;cellular response to radiation;nucleotide-excision repair, DNA incision;DNA strand elongation;DNA recombination;primary metabolic process;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;fatty acid homeostasis;telomere maintenance via telomere lengthening;cellular nitrogen compound biosynthetic process;homeostatic process;cell cycle;DNA biosynthetic process;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;cell cycle process;nuclear DNA replication;organic substance metabolic process;mitotic cell cycle;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;telomere maintenance via recombination;organelle organization;response to abiotic stimulus;mitotic recombination;chromosome organization;telomere maintenance via semi-conservative replication;telomere organization;cellular metabolic process;single-organism organelle organization;DNA metabolic process; 5;4;4;7;5;4;3;4;5;6;7;4;6;5;6;4;5;4;3;7;5;5;4;5;5;6;6;5;3;6;4;4;5;4;3;2;2;4;5;4;3;3;1;2;5;6;3;2;5;6;4;6;4;4;6;5;5;7;2;4;5;6;6;6;3;2;4;5;7;5;5;4;4;6;5;6;4;5;3;5;3;5;3;5;4;3;7;5;5;6;3;4;5; GO:0031974;GO:0016020;GO:1990234;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0000228;GO:0043227;GO:0043226;GO:0005654;GO:0005657;GO:0030894;GO:0031981;GO:0044446;GO:0042575;GO:0005737;GO:0005634;GO:0044454;GO:0043601;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0016234;GO:0016235;GO:0000109;GO:1902494;GO:0061695;GO:0005694;GO:0043625;GO:0032991;GO:0032993;GO:1990391;GO:0005575;GO:0070013;GO:0043596; membrane-enclosed lumen;membrane;transferase complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;nuclear chromosome;membrane-bounded organelle;organelle;nucleoplasm;replication fork;replisome;nuclear lumen;intracellular organelle part;DNA polymerase complex;cytoplasm;nucleus;nuclear chromosome part;nuclear replisome;cell part;cell;intracellular;non-membrane-bounded organelle;inclusion body;aggresome;nucleotide-excision repair complex;catalytic complex;transferase complex, transferring phosphorus-containing groups;chromosome;delta DNA polymerase complex;macromolecular complex;protein-DNA complex;DNA repair complex;cellular_component;intracellular organelle lumen;nuclear replication fork; 2;2;5;3;4;4;3;4;3;4;2;3;5;3;2;5;5;4;5;3;4;4;5;5;5;2;2;3;3;4;5;5;4;6;5;5;2;3;4;1;4;6; GO:1901363;GO:0000166;GO:0016740;GO:0046872;GO:0016895;GO:0016787;GO:0034061;GO:0003674;GO:0005488;GO:0003677;GO:1901265;GO:0008408;GO:0043169;GO:0016788;GO:0003824;GO:0016779;GO:0004536;GO:0097159;GO:0003684;GO:0004527;GO:0016796;GO:0004529;GO:0043167;GO:0051539;GO:0004518;GO:0016772;GO:0044877;GO:0003682;GO:0051536;GO:0003676;GO:0051540;GO:0003887;GO:0036094;GO:0008296; heterocyclic compound binding;nucleotide binding;transferase activity;metal ion binding;exodeoxyribonuclease activity, producing 5'-phosphomonoesters;hydrolase activity;DNA polymerase activity;molecular_function;binding;DNA binding;nucleoside phosphate binding;3'-5' exonuclease activity;cation binding;hydrolase activity, acting on ester bonds;catalytic activity;nucleotidyltransferase activity;deoxyribonuclease activity;organic cyclic compound binding;damaged DNA binding;exonuclease activity;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;exodeoxyribonuclease activity;ion binding;4 iron, 4 sulfur cluster binding;nuclease activity;transferase activity, transferring phosphorus-containing groups;macromolecular complex binding;chromatin binding;iron-sulfur cluster binding;nucleic acid binding;metal cluster binding;DNA-directed DNA polymerase activity;small molecule binding;3'-5'-exodeoxyribonuclease activity; 3;4;3;5;8;3;6;1;2;5;4;7;4;4;2;5;6;3;6;6;7;7;3;5;5;4;3;4;4;4;3;7;3;8; K02327 map00230;map00240;map01100;map03030;map03410;map03420;map03430;map03440;map05166; Purine metabolism;Pyrimidine metabolism;Metabolic pathways;DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination;HTLV-I infection; IPR017964;IPR006134;IPR023211;IPR006133;IPR006172;IPR012337;IPR025687; DNA-directed DNA polymerase, family B, conserved site;DNA-directed DNA polymerase, family B, multifunctional domain;DNA polymerase, palm domain;DNA-directed DNA polymerase, family B, exonuclease domain;DNA-directed DNA polymerase, family B;Ribonuclease H-like domain;C4-type zinc-finger of DNA polymerase delta; nucleus Hs4505933 2263.0 L [L] Replication, recombination and repair; Q7Z7G0 Target of Nesh-SH3 OS=Homo sapiens OX=9606 GN=ABI3BP PE=1 SV=1 - [TARSH_HUMAN] 0.906 0.905 1.331 1.086 0.798 1.409 1.001104972 nan 1.360902256 nan 1.470718232 nan 1.76566416 nan GO:0030155;GO:0050789;GO:0044699;GO:0045785;GO:0016043;GO:0065007;GO:0071840;GO:0043062;GO:0048518;GO:0022610;GO:0031589;GO:0010810;GO:0010811;GO:0009987;GO:0050794;GO:0044763;GO:0007155;GO:0030198;GO:0008150;GO:0048522; regulation of cell adhesion;regulation of biological process;single-organism process;positive regulation of cell adhesion;cellular component organization;biological regulation;cellular component organization or biogenesis;extracellular structure organization;positive regulation of biological process;biological adhesion;cell-substrate adhesion;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;cellular process;regulation of cellular process;single-organism cellular process;cell adhesion;extracellular matrix organization;biological_process;positive regulation of cellular process; 4;2;2;4;3;2;2;4;2;2;4;5;5;2;3;3;3;5;1;3; GO:0031012;GO:0005614;GO:0005615;GO:0005576;GO:0044421;GO:0005575;GO:0005578; extracellular matrix;interstitial matrix;extracellular space;extracellular region;extracellular region part;cellular_component;proteinaceous extracellular matrix; 2;4;3;2;2;1;3; GO:0003674;GO:0005488;GO:0043168;GO:0005539;GO:0043167;GO:1901681;GO:0008201;GO:0097367; molecular_function;binding;anion binding;glycosaminoglycan binding;ion binding;sulfur compound binding;heparin binding;carbohydrate derivative binding; 1;2;4;4;3;3;4;3; IPR003961;IPR013783; Fibronectin type III;Immunoglobulin-like fold; extracellular Q7Z7G1 Cytokine-dependent hematopoietic cell linker OS=Homo sapiens OX=9606 GN=CLNK PE=1 SV=2 - [CLNK_HUMAN] 0.928 1.214 1.226 0.943 0.991 0.464 0.764415157 nan 0.951564077 nan 1.009884679 nan 0.468213925 nan GO:0048584;GO:0048583;GO:0023056;GO:0007165;GO:0007166;GO:0023051;GO:0007169;GO:0010647;GO:0010646;GO:0050789;GO:0044699;GO:0002376;GO:0051716;GO:0009966;GO:0009967;GO:0008150;GO:0065007;GO:0048518;GO:0007167;GO:0009987;GO:0050794;GO:0044763;GO:0006955;GO:0007154;GO:0044700;GO:0035556;GO:0050896;GO:0023052;GO:0048522; positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of signaling;signal transduction;cell surface receptor signaling pathway;regulation of signaling;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of cell communication;regulation of cell communication;regulation of biological process;single-organism process;immune system process;cellular response to stimulus;regulation of signal transduction;positive regulation of signal transduction;biological_process;biological regulation;positive regulation of biological process;enzyme linked receptor protein signaling pathway;cellular process;regulation of cellular process;single-organism cellular process;immune response;cell communication;single organism signaling;intracellular signal transduction;response to stimulus;signaling;positive regulation of cellular process; 3;3;3;4;5;3;7;4;4;2;2;2;3;4;4;1;2;2;6;2;3;3;3;4;3;5;2;2;3; GO:0044464;GO:0005623;GO:0005622;GO:0005575; cell part;cell;intracellular;cellular_component; 2;2;3;1; GO:0003674;GO:0005070;GO:0060090;GO:0030674;GO:0035591;GO:0005515;GO:0005488; molecular_function;SH3/SH2 adaptor activity;binding, bridging;protein binding, bridging;signaling adaptor activity;protein binding;binding; 1;5;3;4;4;3;2; IPR000980; SH2 domain; nucleus Q96M95 Coiled-coil domain-containing protein 42 OS=Homo sapiens OX=9606 GN=CCDC42 PE=1 SV=2 - [CCD42_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan IPR025252; Domain of unknown function DUF4200; cytosol P00488 Coagulation factor XIII A chain OS=Homo sapiens OX=9606 GN=F13A1 PE=1 SV=4 - [F13A_HUMAN] 1.11 1.085 0.828 1.264 0.929 1.201 1.023041475 nan 1.360602799 nan 0.763133641 nan 1.292787944 nan GO:0018149;GO:0007599;GO:0007596;GO:0032501;GO:0044699;GO:0044267;GO:0044260;GO:0002576;GO:0006887;GO:0001775;GO:0009611;GO:0071704;GO:0030168;GO:0065007;GO:0065008;GO:0016192;GO:0045055;GO:0006810;GO:0044765;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0051179;GO:1902578;GO:0042060;GO:0044238;GO:0046903;GO:0044707;GO:0019538;GO:0050896;GO:0032940;GO:0044237;GO:0043170;GO:0050817;GO:0050878;GO:0006950;GO:0044763; peptide cross-linking;hemostasis;blood coagulation;multicellular organismal process;single-organism process;cellular protein metabolic process;cellular macromolecule metabolic process;platelet degranulation;exocytosis;cell activation;response to wounding;organic substance metabolic process;platelet activation;biological regulation;regulation of biological quality;vesicle-mediated transport;regulated exocytosis;transport;single-organism transport;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;localization;single-organism localization;wound healing;primary metabolic process;secretion;single-multicellular organism process;protein metabolic process;response to stimulus;secretion by cell;cellular metabolic process;macromolecule metabolic process;coagulation;regulation of body fluid levels;response to stress;single-organism cellular process; 7;5;5;2;2;5;4;7;5;4;4;3;5;2;3;5;6;4;4;2;6;5;5;1;2;3;2;3;5;3;5;3;4;2;4;3;4;4;4;3;3; GO:0031974;GO:0043229;GO:0005623;GO:0060205;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0031983;GO:0031982;GO:0016023;GO:0031410;GO:0072562;GO:0031988;GO:0044433;GO:0005576;GO:0005575;GO:0099503;GO:0030141;GO:0005615;GO:0097708;GO:0034774;GO:0031091;GO:0043231;GO:0031093;GO:0043233;GO:0044464;GO:0044446;GO:0044444;GO:0044424;GO:0044421;GO:0044422;GO:0012505; membrane-enclosed lumen;intracellular organelle;cell;cytoplasmic membrane-bounded vesicle lumen;intracellular;membrane-bounded organelle;organelle;cytoplasm;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;blood microparticle;membrane-bounded vesicle;cytoplasmic vesicle part;extracellular region;cellular_component;secretory vesicle;secretory granule;extracellular space;intracellular vesicle;secretory granule lumen;platelet alpha granule;intracellular membrane-bounded organelle;platelet alpha granule lumen;organelle lumen;cell part;intracellular organelle part;cytoplasmic part;intracellular part;extracellular region part;organelle part;endomembrane system; 2;3;2;5;3;3;2;4;4;4;5;5;3;5;4;2;1;6;4;3;4;5;5;4;6;3;2;3;4;3;2;2;3; GO:0005488;GO:0003810;GO:0003674;GO:0043167;GO:0016740;GO:0016746;GO:0043169;GO:0003824;GO:0046872;GO:0016755; binding;protein-glutamine gamma-glutamyltransferase activity;molecular_function;ion binding;transferase activity;transferase activity, transferring acyl groups;cation binding;catalytic activity;metal ion binding;transferase activity, transferring amino-acyl groups; 2;6;1;3;3;4;4;2;5;5; K03917 map04610; Complement and coagulation cascades; IPR002931;IPR013783;IPR013808;IPR001102;IPR014756;IPR034810;IPR008958;IPR023608; Transglutaminase-like;Immunoglobulin-like fold;Transglutaminase, active site;Transglutaminase, N-terminal;Immunoglobulin E-set;Coagulation factor XIII A chain;Transglutaminase, C-terminal;Protein-glutamine gamma-glutamyltransferase, animal; cytosol Hs20556219 1526.0 V [V] Defense mechanisms; P23381 Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS PE=1 SV=2 - [SYWC_HUMAN] 0.996 0.981 1.083 0.854 1.04 1.466 1.01529052 0.636728886 0.821153846 0.020218347 1.103975535 0.57609575 1.409615385 0.062793422 GO:0072359;GO:0072358;GO:0044281;GO:1901360;GO:0044710;GO:0043043;GO:0048514;GO:0048519;GO:0042127;GO:0043436;GO:0046483;GO:1901564;GO:0044707;GO:1901566;GO:0019538;GO:0043038;GO:0043039;GO:0022603;GO:1901342;GO:0006807;GO:0034660;GO:1901576;GO:0044260;GO:0001568;GO:0065007;GO:0048646;GO:0050793;GO:0050794;GO:0008150;GO:0008152;GO:0016070;GO:0044271;GO:0043603;GO:0006518;GO:0006436;GO:0051239;GO:0044249;GO:0034641;GO:0034645;GO:0009653;GO:0044699;GO:0006139;GO:0001944;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:0043604;GO:0006082;GO:0043170;GO:0048731;GO:0019752;GO:0090304;GO:0001525;GO:0007275;GO:0006520;GO:0045765;GO:0050789;GO:0071704;GO:0010467;GO:0044267;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0044238;GO:0048856;GO:0044237;GO:0006399;GO:2000026;GO:0006418;GO:0006412;GO:0048523; circulatory system development;cardiovascular system development;small molecule metabolic process;organic cyclic compound metabolic process;single-organism metabolic process;peptide biosynthetic process;blood vessel morphogenesis;negative regulation of biological process;regulation of cell proliferation;oxoacid metabolic process;heterocycle metabolic process;organonitrogen compound metabolic process;single-multicellular organism process;organonitrogen compound biosynthetic process;protein metabolic process;amino acid activation;tRNA aminoacylation;regulation of anatomical structure morphogenesis;regulation of vasculature development;nitrogen compound metabolic process;ncRNA metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;blood vessel development;biological regulation;anatomical structure formation involved in morphogenesis;regulation of developmental process;regulation of cellular process;biological_process;metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;cellular amide metabolic process;peptide metabolic process;tryptophanyl-tRNA aminoacylation;regulation of multicellular organismal process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;vasculature development;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;amide biosynthetic process;organic acid metabolic process;macromolecule metabolic process;system development;carboxylic acid metabolic process;nucleic acid metabolic process;angiogenesis;multicellular organism development;cellular amino acid metabolic process;regulation of angiogenesis;regulation of biological process;organic substance metabolic process;gene expression;cellular protein metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;primary metabolic process;anatomical structure development;cellular metabolic process;tRNA metabolic process;regulation of multicellular organismal development;tRNA aminoacylation for protein translation;translation;negative regulation of cellular process; 5;5;4;4;3;6;4;2;4;5;4;4;3;5;4;5;6;4;5;3;6;4;4;4;2;3;3;3;1;2;5;5;5;5;8;3;4;4;5;3;2;4;5;2;4;2;3;2;4;6;4;4;4;6;5;4;4;4;5;2;3;5;5;3;3;5;3;3;3;3;7;4;7;6;3; GO:0031982;GO:0043230;GO:0005829;GO:0043231;GO:0044424;GO:0044421;GO:0005622;GO:0043227;GO:0043226;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0070062;GO:1903561;GO:0005575;GO:0005576; vesicle;extracellular organelle;cytosol;intracellular membrane-bounded organelle;intracellular part;extracellular region part;intracellular;membrane-bounded organelle;organelle;cytoplasmic part;cytoplasm;nucleus;cell part;intracellular organelle;cell;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;3;5;4;3;2;3;3;2;4;4;5;2;3;2;4;3;1;2; GO:1901363;GO:0004812;GO:0000166;GO:0097367;GO:0005524;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0043168;GO:0003824;GO:0036094;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0001883;GO:0001882;GO:0004830;GO:0016874;GO:0016875;GO:0016876; heterocyclic compound binding;aminoacyl-tRNA ligase activity;nucleotide binding;carbohydrate derivative binding;ATP binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;anion binding;catalytic activity;small molecule binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;tryptophan-tRNA ligase activity;ligase activity;ligase activity, forming carbon-oxygen bonds;ligase activity, forming aminoacyl-tRNA and related compounds; 3;6;4;3;6;1;2;4;5;5;4;2;3;3;6;5;6;4;5;3;6;5;4;7;3;4;5; K01867 map00970; Aminoacyl-tRNA biosynthesis; IPR014729;IPR000738;IPR009068;IPR001412;IPR002306;IPR002305; Rossmann-like alpha/beta/alpha sandwich fold;WHEP-TRS domain;S15/NS1, RNA-binding;Aminoacyl-tRNA synthetase, class I, conserved site;Tryptophan-tRNA ligase;Aminoacyl-tRNA synthetase, class Ic; cytosol Hs14754335 983.0 J [J] Translation, ribosomal structure and biogenesis; P52798 Ephrin-A4 OS=Homo sapiens OX=9606 GN=EFNA4 PE=1 SV=1 - [EFNA4_HUMAN] 0.369 1.873 0.518 0.511 2.167 0.459 0.197010144 nan 0.235809875 nan 0.276561666 nan 0.211813567 nan GO:0048468;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0051716;GO:0042330;GO:0048869;GO:0006935;GO:0097485;GO:0044700;GO:0044707;GO:0009605;GO:0006928;GO:0031175;GO:0050789;GO:0000904;GO:0000902;GO:0016043;GO:0065007;GO:0044699;GO:0061564;GO:0050794;GO:0008150;GO:0048013;GO:0050896;GO:0048812;GO:0030154;GO:0023052;GO:0007154;GO:0007411;GO:0009653;GO:0032502;GO:0032501;GO:0009987;GO:0007409;GO:0032990;GO:0048731;GO:0030030;GO:0007275;GO:0032989;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044763;GO:0007267;GO:0042221;GO:0022008;GO:0040011;GO:0048699;GO:0048858;GO:0007399;GO:0048856; cell development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;taxis;cellular developmental process;chemotaxis;neuron projection guidance;single organism signaling;single-multicellular organism process;response to external stimulus;movement of cell or subcellular component;neuron projection development;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;biological regulation;single-organism process;axon development;regulation of cellular process;biological_process;ephrin receptor signaling pathway;response to stimulus;neuron projection morphogenesis;cell differentiation;signaling;cell communication;axon guidance;anatomical structure morphogenesis;developmental process;multicellular organismal process;cellular process;axonogenesis;cell part morphogenesis;system development;cell projection organization;multicellular organism development;cellular component morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism cellular process;cell-cell signaling;response to chemical;neurogenesis;locomotion;generation of neurons;cell projection morphogenesis;nervous system development;anatomical structure development; 4;4;5;6;7;2;3;3;4;4;5;3;3;3;4;5;2;5;5;3;2;2;6;3;1;8;2;6;5;2;4;6;3;2;2;2;7;5;4;4;4;4;5;6;6;3;3;4;3;6;2;7;5;5;3; GO:0016021;GO:0016020;GO:0044425;GO:0031226;GO:0031224;GO:0031225;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0005887;GO:0005886;GO:0005575;GO:0005576; integral component of membrane;membrane;membrane part;intrinsic component of plasma membrane;intrinsic component of membrane;anchored component of membrane;plasma membrane part;cell part;cell;cell periphery;integral component of plasma membrane;plasma membrane;cellular_component;extracellular region; 4;2;2;4;3;4;3;2;2;3;4;3;1;2; GO:0060089;GO:0004714;GO:0004713;GO:0046875;GO:0099600;GO:0003674;GO:0005488;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0005003;GO:0005005;GO:0016740;GO:0005515;GO:0005102;GO:0038023;GO:0004872;GO:0004871;GO:0004672;GO:0004888;GO:0019199; molecular transducer activity;transmembrane receptor protein tyrosine kinase activity;protein tyrosine kinase activity;ephrin receptor binding;transmembrane receptor activity;molecular_function;binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;ephrin receptor activity;transmembrane-ephrin receptor activity;transferase activity;protein binding;receptor binding;signaling receptor activity;receptor activity;signal transducer activity;protein kinase activity;transmembrane signaling receptor activity;transmembrane receptor protein kinase activity; 2;6;7;5;4;1;2;5;2;5;4;7;8;3;3;4;3;3;2;6;4;5; K05462 map04014;map04015;map04151;map04360; Ras signaling pathway;Rap1 signaling pathway;PI3K-Akt signaling pathway;Axon guidance; IPR008972;IPR019765;IPR001799;IPR034252;IPR031328; Cupredoxin;Ephrin, conserved site;Ephrin receptor-binding domain;Ephrin-A ectodomain;Ephrin; mitochondria Hs4885197 404.0 T [T] Signal transduction mechanisms; Q9UHG3 Prenylcysteine oxidase 1 OS=Homo sapiens OX=9606 GN=PCYOX1 PE=1 SV=3 - [PCYOX_HUMAN] 1.057 1.177 0.817 1.106 1.126 0.966 0.898045879 0.028862269 0.982238011 0.318487529 0.694137638 0.000491722 0.857904085 0.522816652 GO:0044281;GO:0044282;GO:0044712;GO:0044710;GO:0000098;GO:0000096;GO:0030163;GO:0043436;GO:0006575;GO:1901564;GO:0019538;GO:0016054;GO:0009063;GO:0006807;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0008150;GO:0008152;GO:0051603;GO:0044273;GO:0046395;GO:1901565;GO:0044248;GO:0044699;GO:0006508;GO:0009987;GO:0019941;GO:0044257;GO:0006082;GO:0043170;GO:0030327;GO:0030328;GO:0030329;GO:0019752;GO:0043632;GO:0006520;GO:0042219;GO:0071704;GO:0044763;GO:0009056;GO:0009057;GO:0044238;GO:0044237;GO:0006790; small molecule metabolic process;small molecule catabolic process;single-organism catabolic process;single-organism metabolic process;sulfur amino acid catabolic process;sulfur amino acid metabolic process;protein catabolic process;oxoacid metabolic process;cellular modified amino acid metabolic process;organonitrogen compound metabolic process;protein metabolic process;organic acid catabolic process;cellular amino acid catabolic process;nitrogen compound metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;biological_process;metabolic process;proteolysis involved in cellular protein catabolic process;sulfur compound catabolic process;carboxylic acid catabolic process;organonitrogen compound catabolic process;cellular catabolic process;single-organism process;proteolysis;cellular process;modification-dependent protein catabolic process;cellular protein catabolic process;organic acid metabolic process;macromolecule metabolic process;prenylated protein catabolic process;prenylcysteine catabolic process;prenylcysteine metabolic process;carboxylic acid metabolic process;modification-dependent macromolecule catabolic process;cellular amino acid metabolic process;cellular modified amino acid catabolic process;organic substance metabolic process;single-organism cellular process;catabolic process;macromolecule catabolic process;primary metabolic process;cellular metabolic process;sulfur compound metabolic process; 4;5;4;3;6;5;5;5;4;4;4;5;5;3;5;4;5;4;1;2;6;5;6;5;4;2;5;2;7;6;4;4;8;6;5;6;6;4;5;3;3;3;5;3;3;4; GO:0034358;GO:0031982;GO:0005773;GO:0016020;GO:0005774;GO:0034361;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044437;GO:0034385;GO:0044446;GO:0044444;GO:0000323;GO:1990777;GO:0005737;GO:0031090;GO:0032994;GO:0044464;GO:0005623;GO:0071944;GO:0005575;GO:0070062;GO:0098805;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005764;GO:0005576; plasma lipoprotein particle;vesicle;vacuole;membrane;vacuolar membrane;very-low-density lipoprotein particle;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;vacuolar part;triglyceride-rich lipoprotein particle;intracellular organelle part;cytoplasmic part;lytic vacuole;lipoprotein particle;cytoplasm;organelle membrane;protein-lipid complex;cell part;cell;cell periphery;cellular_component;extracellular exosome;whole membrane;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;lysosome;extracellular region; 3;4;5;2;4;5;4;3;4;3;2;2;3;3;3;2;4;4;3;4;6;4;4;3;3;2;2;3;1;4;3;3;3;3;2;7;2; GO:0008509;GO:0016818;GO:0016817;GO:0003674;GO:0016887;GO:0042623;GO:0015399;GO:0022804;GO:0016787;GO:0017111;GO:0003824;GO:0008555;GO:0022891;GO:0022892;GO:0043492;GO:0015075;GO:0016462;GO:0015662;GO:0016491;GO:0016820;GO:0016667;GO:0005215;GO:0016670;GO:0015103;GO:0015108;GO:0042625;GO:0042626;GO:0015405;GO:0001735;GO:0022857;GO:0022853; anion transmembrane transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;molecular_function;ATPase activity;ATPase activity, coupled;primary active transmembrane transporter activity;active transmembrane transporter activity;hydrolase activity;nucleoside-triphosphatase activity;catalytic activity;chloride-transporting ATPase activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;ATPase activity, coupled to movement of substances;ion transmembrane transporter activity;pyrophosphatase activity;ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;oxidoreductase activity;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;oxidoreductase activity, acting on a sulfur group of donors;transporter activity;oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor;inorganic anion transmembrane transporter activity;chloride transmembrane transporter activity;ATPase coupled ion transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of substances;P-P-bond-hydrolysis-driven transmembrane transporter activity;prenylcysteine oxidase activity;transmembrane transporter activity;active ion transmembrane transporter activity; 6;5;4;1;8;9;5;4;3;7;2;8;4;3;10;5;6;7;3;5;4;2;5;7;8;6;6;6;6;3;5; K05906 map00900;map01130; Terpenoid backbone biosynthesis;Biosynthesis of antibiotics; IPR017046;IPR023753;IPR010795; Prenylcysteine oxidase;FAD/NAD(P)-binding domain;Prenylcysteine lyase; extracellular 193212463 62.8 H [H] Coenzyme transport and metabolism; COG1232 Protoporphyrinogen oxidase Q86WI3 Protein NLRC5 OS=Homo sapiens OX=9606 GN=NLRC5 PE=1 SV=3 - [NLRC5_HUMAN] 0.602 0.722 1.753 0.504 0.957 2.477 0.833795014 nan 0.526645768 nan 2.427977839 nan 2.588296761 nan GO:0019220;GO:0019221;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:2000113;GO:0031349;GO:0031348;GO:0007165;GO:0007166;GO:1901362;GO:0031347;GO:0080090;GO:0051716;GO:0010605;GO:0010604;GO:0043207;GO:0009966;GO:0009615;GO:0010467;GO:0043433;GO:0044092;GO:0048518;GO:0065007;GO:0046483;GO:0051172;GO:1902680;GO:0060255;GO:0006366;GO:0051090;GO:2001141;GO:0051707;GO:0010033;GO:0051704;GO:0042325;GO:0044700;GO:0009607;GO:0044707;GO:0009605;GO:0044249;GO:0002376;GO:0007154;GO:0045824;GO:0019438;GO:0010648;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0051254;GO:0010629;GO:0006807;GO:0045935;GO:0043170;GO:0050789;GO:0097659;GO:0045934;GO:1901576;GO:0044260;GO:0071357;GO:0043549;GO:0002684;GO:0002682;GO:0002683;GO:0001960;GO:0001961;GO:0065009;GO:0018130;GO:0034097;GO:0006139;GO:0050790;GO:0009889;GO:0050794;GO:0006952;GO:0006950;GO:0032480;GO:0008150;GO:0008152;GO:0006955;GO:0060761;GO:0060760;GO:0016070;GO:1902679;GO:0044271;GO:0009968;GO:0071345;GO:0050896;GO:0071346;GO:0060330;GO:0051338;GO:0032088;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0009967;GO:0010558;GO:0051171;GO:0032774;GO:0016310;GO:0051173;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0060759;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0045343;GO:0045341;GO:0045345;GO:0051241;GO:1903508;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0034645;GO:0098542;GO:0045893;GO:0048519;GO:0051239;GO:0051607;GO:0050777;GO:0050776;GO:0001959;GO:0051253;GO:0051252;GO:0050778;GO:0001816;GO:0001817;GO:0010628;GO:0045944;GO:0032479;GO:0080134;GO:0001818;GO:0060340;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0051174;GO:0032606;GO:0090304;GO:0031328;GO:1901360;GO:2000112;GO:0071704;GO:0071310;GO:0006357;GO:0010468;GO:0045089;GO:0045088;GO:0019219;GO:0045087;GO:0006793;GO:0034340;GO:0034341;GO:0060332;GO:0060333;GO:0009058;GO:0009059;GO:0044763;GO:0060337;GO:0060334;GO:0060335;GO:0042221;GO:0060338;GO:0060339;GO:0044238;GO:0044237;GO:0006796;GO:0002252;GO:0045892;GO:0034654;GO:0048523;GO:0048522; regulation of phosphate metabolic process;cytokine-mediated signaling pathway;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;negative regulation of cellular macromolecule biosynthetic process;positive regulation of defense response;negative regulation of defense response;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;regulation of defense response;regulation of primary metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;response to external biotic stimulus;regulation of signal transduction;response to virus;gene expression;negative regulation of sequence-specific DNA binding transcription factor activity;negative regulation of molecular function;positive regulation of biological process;biological regulation;heterocycle metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of RNA biosynthetic process;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of sequence-specific DNA binding transcription factor activity;regulation of RNA biosynthetic process;response to other organism;response to organic substance;multi-organism process;regulation of phosphorylation;single organism signaling;response to biotic stimulus;single-multicellular organism process;response to external stimulus;cellular biosynthetic process;immune system process;cell communication;negative regulation of innate immune response;aromatic compound biosynthetic process;negative regulation of cell communication;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;negative regulation of gene expression;nitrogen compound metabolic process;positive regulation of nucleobase-containing compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular response to type I interferon;regulation of kinase activity;positive regulation of immune system process;regulation of immune system process;negative regulation of immune system process;negative regulation of cytokine-mediated signaling pathway;positive regulation of cytokine-mediated signaling pathway;regulation of molecular function;heterocycle biosynthetic process;response to cytokine;nucleobase-containing compound metabolic process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;defense response;response to stress;negative regulation of type I interferon production;biological_process;metabolic process;immune response;negative regulation of response to cytokine stimulus;positive regulation of response to cytokine stimulus;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;negative regulation of signal transduction;cellular response to cytokine stimulus;response to stimulus;cellular response to interferon-gamma;regulation of response to interferon-gamma;regulation of transferase activity;negative regulation of NF-kappaB transcription factor activity;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of signal transduction;negative regulation of macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;RNA biosynthetic process;phosphorylation;positive regulation of nitrogen compound metabolic process;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;regulation of response to cytokine stimulus;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MHC class I biosynthetic process;MHC class I biosynthetic process;positive regulation of MHC class I biosynthetic process;negative regulation of multicellular organismal process;positive regulation of nucleic acid-templated transcription;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular macromolecule biosynthetic process;defense response to other organism;positive regulation of transcription, DNA-templated;negative regulation of biological process;regulation of multicellular organismal process;defense response to virus;negative regulation of immune response;regulation of immune response;regulation of cytokine-mediated signaling pathway;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of immune response;cytokine production;regulation of cytokine production;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;regulation of type I interferon production;regulation of response to stress;negative regulation of cytokine production;positive regulation of type I interferon-mediated signaling pathway;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of phosphorus metabolic process;type I interferon production;nucleic acid metabolic process;positive regulation of cellular biosynthetic process;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of innate immune response;regulation of innate immune response;regulation of nucleobase-containing compound metabolic process;innate immune response;phosphorus metabolic process;response to type I interferon;response to interferon-gamma;positive regulation of response to interferon-gamma;interferon-gamma-mediated signaling pathway;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;type I interferon signaling pathway;regulation of interferon-gamma-mediated signaling pathway;positive regulation of interferon-gamma-mediated signaling pathway;response to chemical;regulation of type I interferon-mediated signaling pathway;negative regulation of type I interferon-mediated signaling pathway;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;immune effector process;negative regulation of transcription, DNA-templated;nucleobase-containing compound biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 6;6;3;3;3;3;6;4;4;4;5;5;5;4;3;4;4;4;4;4;5;5;4;2;2;4;4;6;4;7;4;6;3;4;2;7;3;3;3;3;4;2;4;5;5;4;3;3;4;4;5;5;3;5;4;2;7;5;4;4;6;6;3;3;3;5;5;3;5;5;4;4;4;3;4;3;5;1;2;3;4;4;5;6;5;4;6;2;6;5;5;6;6;5;5;6;4;5;4;6;6;4;3;3;4;2;4;4;3;4;4;2;6;6;6;3;7;2;2;4;7;7;5;4;6;2;3;4;4;4;5;5;5;4;4;4;5;7;5;4;4;6;5;5;4;4;4;5;5;5;5;4;6;3;5;7;5;5;5;5;4;4;5;5;5;7;3;5;3;7;6;6;3;6;6;3;3;5;3;6;5;3;3; GO:0005829;GO:0043231;GO:0044424;GO:0043227;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0044444;GO:0043226;GO:0043229;GO:0005575; cytosol;intracellular membrane-bounded organelle;intracellular part;membrane-bounded organelle;cytoplasm;nucleus;cell part;cell;intracellular;cytoplasmic part;organelle;intracellular organelle;cellular_component; 5;4;3;3;4;5;2;2;3;4;2;3;1; GO:1901363;GO:0000975;GO:0044212;GO:0001067;GO:0097367;GO:0001012;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0001046;GO:0017076;GO:0005524;GO:0043168;GO:0000166;GO:0097159;GO:0000976;GO:0032555;GO:0000979;GO:0032553;GO:0035639;GO:0043565;GO:0036094;GO:0043167;GO:0003690;GO:0030554;GO:1990837;GO:0001883;GO:0001882;GO:0032549;GO:1901265;GO:0032559;GO:0000977;GO:0032550;GO:0001047; heterocyclic compound binding;regulatory region DNA binding;transcription regulatory region DNA binding;regulatory region nucleic acid binding;carbohydrate derivative binding;RNA polymerase II regulatory region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter sequence-specific DNA binding;purine nucleotide binding;ATP binding;anion binding;nucleotide binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;purine ribonucleotide binding;RNA polymerase II core promoter sequence-specific DNA binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;sequence-specific DNA binding;small molecule binding;ion binding;double-stranded DNA binding;adenyl nucleotide binding;sequence-specific double-stranded DNA binding;purine nucleoside binding;nucleoside binding;ribonucleoside binding;nucleoside phosphate binding;adenyl ribonucleotide binding;RNA polymerase II regulatory region sequence-specific DNA binding;purine ribonucleoside binding;core promoter binding; 3;6;7;5;3;8;1;2;4;5;9;5;6;4;4;3;8;5;10;4;5;6;3;3;6;6;7;5;4;5;4;6;9;6;8; K22615 IPR007111;IPR032675;IPR001611;IPR006553;IPR027417;IPR025875; NACHT nucleoside triphosphatase;Leucine-rich repeat domain, L domain-like;Leucine-rich repeat;Leucine-rich repeat, cysteine-containing subtype;P-loop containing nucleoside triphosphate hydrolase;Leucine rich repeat 4; cytosol, nucleus Hs14333697 1460.0 S [S] Function unknown; P0CW27 Coiled-coil domain-containing protein 166 OS=Homo sapiens OX=9606 GN=CCDC166 PE=4 SV=1 - [CC166_HUMAN] 1.076 1.065 0.507 1.513 1.019 1.733 1.010328639 nan 1.484789009 nan 0.476056338 nan 1.700686948 nan IPR032777;IPR029584; Domain of unknown function DUF4515;Coiled-coil domain-containing protein 166; nucleus O75916 Regulator of G-protein signaling 9 OS=Homo sapiens OX=9606 GN=RGS9 PE=1 SV=1 - [RGS9_HUMAN] 0.244 0.358 2.521 1.492 0.57 0.379 0.681564246 nan 2.61754386 nan 7.041899441 nan 0.664912281 nan GO:0048585;GO:0048583;GO:0008277;GO:0007165;GO:0051716;GO:0009968;GO:0009966;GO:0048519;GO:0007600;GO:0007603;GO:0007602;GO:0042221;GO:0010033;GO:0003008;GO:0044700;GO:0044707;GO:0016056;GO:0035556;GO:0065007;GO:0014070;GO:0071214;GO:0007186;GO:0009719;GO:0050953;GO:0050794;GO:0008150;GO:0007212;GO:0051606;GO:0050896;GO:0009416;GO:0071482;GO:0032101;GO:0009314;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0044699;GO:0071478;GO:0032502;GO:0032501;GO:0050877;GO:0009987;GO:0009725;GO:0048731;GO:0048545;GO:0022400;GO:0007275;GO:0033993;GO:0050789;GO:0009605;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0007601;GO:0044767;GO:0044763;GO:0043627;GO:0007154;GO:0009628;GO:0007399;GO:0048856;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;regulation of G-protein coupled receptor protein signaling pathway;signal transduction;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;negative regulation of biological process;sensory perception;phototransduction, visible light;phototransduction;response to chemical;response to organic substance;system process;single organism signaling;single-multicellular organism process;rhodopsin mediated signaling pathway;intracellular signal transduction;biological regulation;response to organic cyclic compound;cellular response to abiotic stimulus;G-protein coupled receptor signaling pathway;response to endogenous stimulus;sensory perception of light stimulus;regulation of cellular process;biological_process;dopamine receptor signaling pathway;detection of stimulus;response to stimulus;response to light stimulus;cellular response to light stimulus;regulation of response to external stimulus;response to radiation;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;single-organism process;cellular response to radiation;developmental process;multicellular organismal process;neurological system process;cellular process;response to hormone;system development;response to steroid hormone;regulation of rhodopsin mediated signaling pathway;multicellular organism development;response to lipid;regulation of biological process;response to external stimulus;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;visual perception;single-organism developmental process;single-organism cellular process;response to estrogen;cell communication;response to abiotic stimulus;nervous system development;anatomical structure development;negative regulation of cellular process; 3;3;5;4;3;4;4;2;5;6;5;3;4;3;3;3;6;5;2;5;4;5;3;6;3;1;6;3;2;5;6;4;4;3;2;4;3;4;2;5;2;2;4;2;4;4;5;5;4;5;2;3;4;4;5;6;7;3;3;6;4;3;5;3;3; GO:0016020;GO:0031513;GO:1902494;GO:0042995;GO:0043234;GO:0043231;GO:0001917;GO:0044424;GO:0044425;GO:0009898;GO:0043229;GO:0005929;GO:0043227;GO:0043226;GO:0005834;GO:0019897;GO:0019898;GO:0005737;GO:0005634;GO:0001750;GO:0044459;GO:0031234;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098552;GO:0005575;GO:0072372;GO:0097458;GO:0098562;GO:0005886;GO:0032991;GO:0098797;GO:0098796; membrane;nonmotile primary cilium;catalytic complex;cell projection;protein complex;intracellular membrane-bounded organelle;photoreceptor inner segment;intracellular part;membrane part;cytoplasmic side of plasma membrane;intracellular organelle;cilium;membrane-bounded organelle;organelle;heterotrimeric G-protein complex;extrinsic component of plasma membrane;extrinsic component of membrane;cytoplasm;nucleus;photoreceptor outer segment;plasma membrane part;extrinsic component of cytoplasmic side of plasma membrane;cell part;cell;intracellular;cell periphery;side of membrane;cellular_component;primary cilium;neuron part;cytoplasmic side of membrane;plasma membrane;macromolecular complex;plasma membrane protein complex;membrane protein complex; 2;5;4;3;3;4;4;3;2;4;3;3;3;2;4;4;3;4;5;4;3;4;2;2;3;3;3;1;4;3;4;3;2;4;3; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0030234;GO:0060589;GO:0004871;GO:0008047; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;enzyme regulator activity;nucleoside-triphosphatase regulator activity;signal transducer activity;enzyme activator activity; 2;5;5;1;3;4;2;4; K13765 map04744;map05030; Phototransduction;Cocaine addiction; IPR000591;IPR011991;IPR024066;IPR016137;IPR015898; DEP domain;Winged helix-turn-helix DNA-binding domain;RGS, subdomain 1;RGS domain;G-protein gamma-like domain; mitochondria Hs4506521 821.0 T [T] Signal transduction mechanisms; Q96L50 Leucine-rich repeat protein 1 OS=Homo sapiens OX=9606 GN=LRR1 PE=1 SV=2 - [LLR1_HUMAN] 0.946 0.944 1.349 0.787 1 1.118 1.002118644 0.547766285 0.787 2.06E-06 1.429025424 2.96E-06 1.118 0.058022972 GO:0044267;GO:0044238;GO:0044260;GO:0032446;GO:0019538;GO:0009987;GO:0070647;GO:0006464;GO:0043170;GO:0071704;GO:0043412;GO:0036211;GO:0008150;GO:0044237;GO:0008152;GO:0016567; cellular protein metabolic process;primary metabolic process;cellular macromolecule metabolic process;protein modification by small protein conjugation;protein metabolic process;cellular process;protein modification by small protein conjugation or removal;cellular protein modification process;macromolecule metabolic process;organic substance metabolic process;macromolecule modification;protein modification process;biological_process;cellular metabolic process;metabolic process;protein ubiquitination; 5;3;4;8;4;2;7;6;4;3;5;5;1;3;2;9; K10348 IPR003591;IPR001611;IPR025875;IPR032675; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Leucine rich repeat 4;Leucine-rich repeat domain, L domain-like; cytosol Hs20543273 844.0 R [R] General function prediction only; Q9BUN1 Protein MENT OS=Homo sapiens OX=9606 GN=MENT PE=2 SV=1 - [MENT_HUMAN] 0.914 1.048 1.346 0.851 0.799 1.499 0.872137405 nan 1.065081352 nan 1.284351145 nan 1.876095119 nan GO:0005737;GO:0044446;GO:0043231;GO:0031981;GO:0043233;GO:0005634;GO:0005654;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0043229;GO:0005576;GO:0044428;GO:0031974;GO:0044424;GO:0043227;GO:0043226;GO:0044422; cytoplasm;intracellular organelle part;intracellular membrane-bounded organelle;nuclear lumen;organelle lumen;nucleus;nucleoplasm;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;intracellular organelle;extracellular region;nuclear part;membrane-enclosed lumen;intracellular part;membrane-bounded organelle;organelle;organelle part; 4;3;4;5;3;5;5;2;2;3;1;4;3;2;4;2;3;3;2;2; IPR029292; Methylated in normal thymocytes protein; extracellular Q68CJ6 Nuclear GTPase SLIP-GC OS=Homo sapiens OX=9606 GN=NUGGC PE=2 SV=3 - [SLIP_HUMAN] 0.834 0.872 1.752 0.821 0.761 0.895 0.956422018 nan 1.078843627 nan 2.009174312 nan 1.1760841 nan GO:0044699;GO:0002376;GO:0051716;GO:0007275;GO:0002200;GO:0002520;GO:0032502;GO:0032501;GO:0009987;GO:0044767;GO:0006950;GO:0008150;GO:0002440;GO:0002566;GO:0006974;GO:0044707;GO:0050896;GO:0048856;GO:0002377;GO:0033554;GO:0048731;GO:0016445;GO:0016446; single-organism process;immune system process;cellular response to stimulus;multicellular organism development;somatic diversification of immune receptors;immune system development;developmental process;multicellular organismal process;cellular process;single-organism developmental process;response to stress;biological_process;production of molecular mediator of immune response;somatic diversification of immune receptors via somatic mutation;cellular response to DNA damage stimulus;single-multicellular organism process;response to stimulus;anatomical structure development;immunoglobulin production;cellular response to stress;system development;somatic diversification of immunoglobulins;somatic hypermutation of immunoglobulin genes; 2;2;3;4;3;3;2;2;2;3;3;1;3;4;5;3;2;3;4;4;4;4;5; GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;4;2;2;3;1;3; GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0001883;GO:0000166;GO:0001882;GO:0043168;GO:0019001;GO:0036094;GO:0032561;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0016787;GO:0003824;GO:0032555;GO:0043167;GO:0097367;GO:0097159;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;purine nucleoside binding;nucleotide binding;nucleoside binding;anion binding;guanyl nucleotide binding;small molecule binding;guanyl ribonucleotide binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;hydrolase activity;catalytic activity;purine ribonucleotide binding;ion binding;carbohydrate derivative binding;organic cyclic compound binding;purine ribonucleoside binding;ribonucleotide binding; 5;3;1;2;5;4;4;4;6;3;6;4;5;5;6;3;2;5;3;3;3;6;4; IPR022812;IPR027417; Dynamin superfamily;P-loop containing nucleoside triphosphate hydrolase; nucleus P41222 Prostaglandin-H2 D-isomerase OS=Homo sapiens OX=9606 GN=PTGDS PE=1 SV=1 - [PTGDS_HUMAN] 1.075 1.146 0.928 1.013 0.934 1.088 0.938045375 0.747894868 1.084582441 0.575881648 0.809773124 0.643295563 1.164882227 0.551678258 GO:2000242;GO:2000241;GO:0048583;GO:0007610;GO:0044281;GO:0044283;GO:0044710;GO:0044711;GO:0000003;GO:0048511;GO:0048512;GO:0048519;GO:0042127;GO:0031960;GO:2000254;GO:0032787;GO:0001516;GO:0042752;GO:0045187;GO:0002176;GO:0043436;GO:0010033;GO:0051704;GO:0044703;GO:0044702;GO:0044707;GO:1901568;GO:0044708;GO:0016053;GO:0033559;GO:0042745;GO:0050789;GO:0042749;GO:0007622;GO:1901576;GO:1901570;GO:0065007;GO:0014070;GO:0007623;GO:0006629;GO:0006810;GO:0050795;GO:0050794;GO:0043900;GO:0043901;GO:0008150;GO:0008152;GO:0001676;GO:0051234;GO:0046394;GO:0050896;GO:0006690;GO:0006693;GO:0006692;GO:0022410;GO:0006633;GO:0006631;GO:0051241;GO:0006636;GO:0050802;GO:0022412;GO:0019953;GO:0044249;GO:0044699;GO:0009719;GO:0008285;GO:0032501;GO:0048609;GO:0032504;GO:0008283;GO:0009987;GO:0044255;GO:0006082;GO:0009725;GO:0051239;GO:0048545;GO:0051384;GO:0019752;GO:0007276;GO:0033993;GO:0071704;GO:0019371;GO:2000255;GO:0022414;GO:0009058;GO:0044763;GO:0030431;GO:0036093;GO:0042221;GO:0051179;GO:0008610;GO:0044238;GO:0044237;GO:0046457;GO:0046456;GO:0019369;GO:0072330;GO:0048523; negative regulation of reproductive process;regulation of reproductive process;regulation of response to stimulus;behavior;small molecule metabolic process;small molecule biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;reproduction;rhythmic process;circadian behavior;negative regulation of biological process;regulation of cell proliferation;response to corticosteroid;regulation of male germ cell proliferation;monocarboxylic acid metabolic process;prostaglandin biosynthetic process;regulation of circadian rhythm;regulation of circadian sleep/wake cycle, sleep;male germ cell proliferation;oxoacid metabolic process;response to organic substance;multi-organism process;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;fatty acid derivative metabolic process;single-organism behavior;organic acid biosynthetic process;unsaturated fatty acid metabolic process;circadian sleep/wake cycle;regulation of biological process;regulation of circadian sleep/wake cycle;rhythmic behavior;organic substance biosynthetic process;fatty acid derivative biosynthetic process;biological regulation;response to organic cyclic compound;circadian rhythm;lipid metabolic process;transport;regulation of behavior;regulation of cellular process;regulation of multi-organism process;negative regulation of multi-organism process;biological_process;metabolic process;long-chain fatty acid metabolic process;establishment of localization;carboxylic acid biosynthetic process;response to stimulus;icosanoid metabolic process;prostaglandin metabolic process;prostanoid metabolic process;circadian sleep/wake cycle process;fatty acid biosynthetic process;fatty acid metabolic process;negative regulation of multicellular organismal process;unsaturated fatty acid biosynthetic process;circadian sleep/wake cycle, sleep;cellular process involved in reproduction in multicellular organism;sexual reproduction;cellular biosynthetic process;single-organism process;response to endogenous stimulus;negative regulation of cell proliferation;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cell proliferation;cellular process;cellular lipid metabolic process;organic acid metabolic process;response to hormone;regulation of multicellular organismal process;response to steroid hormone;response to glucocorticoid;carboxylic acid metabolic process;gamete generation;response to lipid;organic substance metabolic process;cyclooxygenase pathway;negative regulation of male germ cell proliferation;reproductive process;biosynthetic process;single-organism cellular process;sleep;germ cell proliferation;response to chemical;localization;lipid biosynthetic process;primary metabolic process;cellular metabolic process;prostanoid biosynthetic process;icosanoid biosynthetic process;arachidonic acid metabolic process;monocarboxylic acid biosynthetic process;negative regulation of cellular process; 3;3;3;2;4;5;3;4;2;2;4;2;4;6;4;7;8;3;5;5;5;4;2;3;3;3;4;3;5;6;5;2;4;3;4;5;2;5;3;4;4;3;3;3;3;1;2;6;3;6;2;5;7;6;5;6;5;3;7;4;4;3;4;2;3;4;2;3;3;3;2;4;4;4;3;5;7;6;4;5;3;7;4;2;3;3;4;4;3;2;5;3;3;7;6;6;7;3; GO:0005783;GO:0031975;GO:0016020;GO:0005794;GO:0005791;GO:0098588;GO:0031965;GO:0031967;GO:0005789;GO:0043230;GO:0043231;GO:0042175;GO:0044428;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043227;GO:0044432;GO:0048471;GO:0005737;GO:0012505;GO:0031982;GO:0044446;GO:0031090;GO:0005634;GO:0005635;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0005615;GO:0044444;GO:0070062;GO:0043226;GO:1903561;GO:0005576; endoplasmic reticulum;envelope;membrane;Golgi apparatus;rough endoplasmic reticulum;bounding membrane of organelle;nuclear membrane;organelle envelope;endoplasmic reticulum membrane;extracellular organelle;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;nuclear part;intracellular part;membrane part;extracellular region part;organelle part;membrane-bounded organelle;endoplasmic reticulum part;perinuclear region of cytoplasm;cytoplasm;endomembrane system;vesicle;intracellular organelle part;organelle membrane;nucleus;nuclear envelope;cell part;intracellular organelle;cell;intracellular;cellular_component;extracellular space;cytoplasmic part;extracellular exosome;organelle;extracellular vesicle;extracellular region; 4;3;2;4;5;4;4;4;3;3;4;3;4;3;2;2;2;3;4;5;4;3;4;3;3;5;4;2;3;2;3;1;3;4;4;2;3;2; GO:0033293;GO:0016860;GO:0003674;GO:0005488;GO:0003824;GO:0031406;GO:0043167;GO:0005504;GO:0005501;GO:0005215;GO:0008289;GO:0016853;GO:0043177;GO:0004667;GO:0036094;GO:0019840;GO:0043168; monocarboxylic acid binding;intramolecular oxidoreductase activity;molecular_function;binding;catalytic activity;carboxylic acid binding;ion binding;fatty acid binding;retinoid binding;transporter activity;lipid binding;isomerase activity;organic acid binding;prostaglandin-D synthase activity;small molecule binding;isoprenoid binding;anion binding; 6;4;1;2;2;5;3;4;5;2;3;3;4;5;3;4;4; K01830 map00590;map01100; Arachidonic acid metabolism;Metabolic pathways; IPR002345;IPR000566;IPR012674;IPR002972;IPR022272; Lipocalin;Lipocalin/cytosolic fatty-acid binding domain;Calycin;Prostaglandin D synthase;Lipocalin family conserved site; extracellular 71278833 49.3 M [M] Cell wall/membrane/envelope biogenesis; COG3040 Bacterial lipocalin Q8NBL1 Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1 - [PGLT1_HUMAN] 0.947 0.773 1.503 0.938 0.876 1.121 1.225097025 nan 1.070776256 nan 1.944372574 nan 1.279680365 nan GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0051716;GO:0007219;GO:0009966;GO:0009967;GO:0048518;GO:0006664;GO:0044700;GO:0044707;GO:0019538;GO:0043170;GO:0044267;GO:0044260;GO:0065007;GO:0006629;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0050896;GO:0043413;GO:0007275;GO:0023056;GO:0044249;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0045747;GO:0032502;GO:1903509;GO:0032501;GO:0006643;GO:0005975;GO:0044255;GO:1901137;GO:1901135;GO:0048731;GO:0009100;GO:0009101;GO:0006486;GO:0050789;GO:0071704;GO:0009987;GO:1901576;GO:0070085;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0008593;GO:0007154;GO:0044238;GO:0006493;GO:0048856;GO:0044237;GO:0048522; positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;cellular response to stimulus;Notch signaling pathway;regulation of signal transduction;positive regulation of signal transduction;positive regulation of biological process;glycolipid metabolic process;single organism signaling;single-multicellular organism process;protein metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;lipid metabolic process;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;response to stimulus;macromolecule glycosylation;multicellular organism development;positive regulation of signaling;cellular biosynthetic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;positive regulation of Notch signaling pathway;developmental process;liposaccharide metabolic process;multicellular organismal process;membrane lipid metabolic process;carbohydrate metabolic process;cellular lipid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;system development;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;regulation of biological process;organic substance metabolic process;cellular process;organic substance biosynthetic process;glycosylation;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of Notch signaling pathway;cell communication;primary metabolic process;protein O-linked glycosylation;anatomical structure development;cellular metabolic process;positive regulation of cellular process; 3;3;5;5;4;5;3;6;4;4;2;6;3;3;4;4;5;4;2;4;3;3;5;5;1;2;4;2;6;4;3;4;2;5;3;4;4;2;5;2;5;2;5;4;4;5;4;4;5;6;4;2;3;2;4;5;6;3;3;5;3;5;4;3;5;3;3;3; GO:0005783;GO:0031974;GO:0031982;GO:0005788;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044432;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:1903561;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;membrane-enclosed lumen;vesicle;endoplasmic reticulum lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;endoplasmic reticulum part;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;extracellular exosome;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 4;2;4;5;3;4;3;3;2;2;3;3;2;4;3;3;4;4;2;2;3;4;3;1;4;2; GO:0016740;GO:0016757;GO:0016758;GO:0003674;GO:0046527;GO:0016763;GO:0035252;GO:0035251;GO:0003824;GO:0030158;GO:0042285;GO:0008194; transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;molecular_function;glucosyltransferase activity;transferase activity, transferring pentosyl groups;UDP-xylosyltransferase activity;UDP-glucosyltransferase activity;catalytic activity;protein xylosyltransferase activity;xylosyltransferase activity;UDP-glycosyltransferase activity; 3;4;5;1;6;5;6;6;2;7;6;5; K13667 map00514; Other types of O-glycan biosynthesis; IPR006598; Lipopolysaccharide-modifying protein; extracellular Hs9910428 557.0 R [R] General function prediction only; O60381 HMG box-containing protein 1 OS=Homo sapiens OX=9606 GN=HBP1 PE=1 SV=2 - [HBP1_HUMAN] 2.039 0.827 0.342 1.329 0.923 0.448 2.465538089 nan 1.439869989 nan 0.413542926 nan 0.485373781 nan GO:0080090;GO:0019222;GO:0051049;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0051716;GO:0045786;GO:0048518;GO:0048519;GO:0051050;GO:0060255;GO:2001141;GO:0046483;GO:0044700;GO:0016055;GO:0019438;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0044699;GO:0018130;GO:0006813;GO:0006812;GO:0006811;GO:0006810;GO:0009889;GO:0050794;GO:0007050;GO:0008150;GO:0008152;GO:0034654;GO:0051234;GO:0016070;GO:0044271;GO:0050896;GO:0044765;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007049;GO:0006139;GO:0015672;GO:0009987;GO:0006725;GO:1903506;GO:0043270;GO:0030001;GO:0032879;GO:0051252;GO:0031326;GO:0031323;GO:0090304;GO:0043266;GO:0022402;GO:0043269;GO:0043268;GO:2000112;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0010959;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0051726;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;regulation of transport;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of cell cycle;positive regulation of biological process;negative regulation of biological process;positive regulation of transport;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;Wnt signaling pathway;aromatic compound biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;single-organism process;heterocycle biosynthetic process;potassium ion transport;cation transport;ion transport;transport;regulation of biosynthetic process;regulation of cellular process;cell cycle arrest;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;establishment of localization;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;single-organism transport;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell cycle;nucleobase-containing compound metabolic process;monovalent inorganic cation transport;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of ion transport;metal ion transport;regulation of localization;regulation of RNA metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of potassium ion transport;cell cycle process;regulation of ion transport;positive regulation of potassium ion transport;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;regulation of metal ion transport;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;localization;single-organism localization;primary metabolic process;regulation of cell cycle;cellular metabolic process;negative regulation of cellular process; 4;3;4;4;5;5;4;3;4;2;2;3;4;6;4;3;6;5;3;4;2;7;4;4;2;2;5;8;6;5;4;4;3;5;1;2;5;3;5;5;2;4;6;5;6;6;4;4;2;5;4;4;7;2;4;7;4;7;3;5;5;4;5;7;4;5;5;6;3;5;5;5;6;3;5;3;4;4;2;3;3;4;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;5;3;5;2;2;3;2;1;4; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0003723; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;RNA binding; 3;1;2;4;5;3;5; K21644 IPR003652;IPR009071; Ataxin, AXH domain;High mobility group box domain; nucleus P01880 Immunoglobulin heavy constant delta OS=Homo sapiens OX=9606 GN=IGHD PE=1 SV=3 - [IGHD_HUMAN] 1.39 0.623 0.976 1.317 0.632 1.4 2.231139647 1.44E-17 2.083860759 1.06E-18 1.566613162 3.74E-06 2.215189873 4.49E-06 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0051716;GO:0043207;GO:0009617;GO:0048518;GO:0065007;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0042742;GO:0050789;GO:0002764;GO:0002768;GO:0016043;GO:0002684;GO:0002682;GO:0006810;GO:0044710;GO:0050794;GO:0006952;GO:0006950;GO:0051249;GO:0008150;GO:0006955;GO:0006958;GO:0051234;GO:0002757;GO:0006897;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0006956;GO:0008152;GO:0023052;GO:0044699;GO:0016064;GO:0008037;GO:0009987;GO:0050871;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0006959;GO:0072376;GO:0002443;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;cellular response to stimulus;response to external biotic stimulus;response to bacterium;positive regulation of biological process;biological regulation;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;defense response to bacterium;regulation of biological process;immune response-regulating signaling pathway;immune response-regulating cell surface receptor signaling pathway;cellular component organization;positive regulation of immune system process;regulation of immune system process;transport;single-organism metabolic process;regulation of cellular process;defense response;response to stress;regulation of lymphocyte activation;biological_process;immune response;complement activation, classical pathway;establishment of localization;immune response-activating signal transduction;endocytosis;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;metabolic process;signaling;single-organism process;immunoglobulin mediated immune response;cell recognition;cellular process;positive regulation of B cell activation;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;humoral immune response;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;4;2;2;6;4;3;3;2;3;5;5;3;4;2;3;5;2;5;6;3;3;3;4;3;3;4;3;5;1;3;5;3;4;6;2;4;4;4;4;2;2;2;7;4;2;6;4;4;5;5;4;5;4;4;6;4;5;4;3;4;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;3; GO:0031982;GO:0016021;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0043227;GO:0031224;GO:0016020;GO:0005623;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;integral component of membrane;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;membrane-bounded organelle;intrinsic component of membrane;membrane;cell;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;4;3;3;2;2;4;3;3;2;2;3;4;3;3;2;3;3;3;2;3;3;4;2;1;2;3; GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102;GO:0005488; molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding;binding; 1;5;3;3;4;2; IPR003006;IPR013783;IPR013151;IPR003597;IPR007110; Immunoglobulin/major histocompatibility complex, conserved site;Immunoglobulin-like fold;Immunoglobulin;Immunoglobulin C1-set;Immunoglobulin-like domain; nucleus A8MYB1 Transmembrane and coiled-coil domain-containing protein 5B OS=Homo sapiens OX=9606 GN=TMCO5B PE=3 SV=1 - [TMC5B_HUMAN] 0.962 1.119 1.171 1.061 0.895 0.887 0.859696157 nan 1.18547486 nan 1.046470063 nan 0.991061453 nan GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; IPR026617; Transmembrane and coiled-coil domain-containing protein 2/5; cytosol O94762 ATP-dependent DNA helicase Q5 OS=Homo sapiens OX=9606 GN=RECQL5 PE=1 SV=2 - [RECQ5_HUMAN] 1.004 1.045 0.735 1.14 1.374 0.924 0.96076555 nan 0.829694323 nan 0.703349282 nan 0.672489083 nan GO:0080090;GO:0019222;GO:0016043;GO:1901362;GO:1901360;GO:0044710;GO:0010605;GO:0071840;GO:0006260;GO:0048519;GO:0032392;GO:0006281;GO:0060255;GO:0032784;GO:0032785;GO:2001141;GO:0046483;GO:0033554;GO:0019438;GO:0071103;GO:0009892;GO:0009890;GO:0006807;GO:0007067;GO:0097659;GO:0000278;GO:1901576;GO:0044260;GO:0065007;GO:0044699;GO:0006366;GO:0006368;GO:0018130;GO:0009889;GO:0051716;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0007059;GO:0016070;GO:0044271;GO:0050896;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0007049;GO:0006139;GO:0000122;GO:0000280;GO:0006996;GO:0034244;GO:0034243;GO:0032508;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0006974;GO:0045892;GO:0051253;GO:0051252;GO:0010629;GO:0043170;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:1903047;GO:0090304;GO:0022402;GO:0051304;GO:0051301;GO:0006354;GO:0006355;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0006310;GO:0044238;GO:0051276;GO:0044237;GO:1902589;GO:0048285;GO:0006259;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;cellular component organization;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;cellular component organization or biogenesis;DNA replication;negative regulation of biological process;DNA geometric change;DNA repair;regulation of macromolecule metabolic process;regulation of DNA-templated transcription, elongation;negative regulation of DNA-templated transcription, elongation;regulation of RNA biosynthetic process;heterocycle metabolic process;cellular response to stress;aromatic compound biosynthetic process;DNA conformation change;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;mitotic nuclear division;nucleic acid-templated transcription;mitotic cell cycle;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;single-organism process;transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;chromosome segregation;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;cell cycle;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;nuclear division;organelle organization;negative regulation of transcription elongation from RNA polymerase II promoter;regulation of transcription elongation from RNA polymerase II promoter;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;negative regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;cell cycle process;chromosome separation;cell division;DNA-templated transcription, elongation;regulation of transcription, DNA-templated;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;DNA recombination;primary metabolic process;chromosome organization;cellular metabolic process;single-organism organelle organization;organelle fission;DNA metabolic process;negative regulation of cellular process; 4;3;3;5;4;3;4;2;6;2;7;4;4;7;7;6;4;4;5;6;3;4;3;5;7;5;4;4;2;2;7;8;5;4;3;3;3;1;2;5;4;5;5;2;5;6;5;6;4;4;5;4;4;7;6;4;8;8;8;2;4;7;7;5;6;5;5;5;4;5;5;4;4;5;5;4;5;4;7;6;6;6;2;3;5;7;5;5;5;6;3;5;3;4;4;6;3;5;3;4;5;5;3; GO:0031974;GO:0016591;GO:0030880;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0000428;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0055029;GO:0044446;GO:0005737;GO:0005634;GO:0044451;GO:0061695;GO:0044464;GO:0005623;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;DNA-directed RNA polymerase II, holoenzyme;RNA polymerase complex;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;DNA-directed RNA polymerase complex;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;nuclear DNA-directed RNA polymerase complex;intracellular organelle part;cytoplasm;nucleus;nucleoplasm part;transferase complex, transferring phosphorus-containing groups;cell part;cell;macromolecular complex;cellular_component;intracellular organelle lumen; 2;6;4;5;4;5;3;4;3;4;3;2;5;3;3;3;2;5;5;3;4;5;5;6;2;2;2;1;4; GO:0001883;GO:1901363;GO:0000166;GO:0032549;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0000993;GO:0043175;GO:0017076;GO:0003674;GO:0005488;GO:0016887;GO:0003678;GO:0042623;GO:0001098;GO:0001099;GO:0005524;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032553;GO:0008026;GO:0035639;GO:0019899;GO:0043167;GO:0032403;GO:0030554;GO:0032550;GO:0005515;GO:0044877;GO:0003676;GO:0001882;GO:0070063;GO:1901265;GO:0017111;GO:0043168; purine nucleoside binding;heterocyclic compound binding;nucleotide binding;ribonucleoside binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;RNA polymerase II core binding;RNA polymerase core enzyme binding;purine nucleotide binding;molecular_function;binding;ATPase activity;DNA helicase activity;ATPase activity, coupled;basal transcription machinery binding;basal RNA polymerase II transcription machinery binding;ATP binding;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;enzyme binding;ion binding;protein complex binding;adenyl nucleotide binding;purine ribonucleoside binding;protein binding;macromolecular complex binding;nucleic acid binding;nucleoside binding;RNA polymerase binding;nucleoside phosphate binding;nucleoside-triphosphatase activity;anion binding; 5;3;4;5;8;5;3;4;9;5;6;5;1;2;8;9;9;4;5;6;3;2;3;3;6;6;5;4;10;5;4;3;4;6;6;3;3;4;4;5;4;7;4; K10902 IPR004589;IPR011545;IPR032284;IPR001650;IPR010716;IPR002464;IPR014001;IPR011991;IPR027417; DNA helicase, ATP-dependent, RecQ type;DEAD/DEAH box helicase domain;ATP-dependent DNA helicase RecQ, zinc-binding domain;Helicase, C-terminal;RecQ helicase-like 5;DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;Helicase superfamily 1/2, ATP-binding domain;Winged helix-turn-helix DNA-binding domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs4759032 855.0 L [L] Replication, recombination and repair; Q96NU7 Probable imidazolonepropionase OS=Homo sapiens OX=9606 GN=AMDHD1 PE=1 SV=2 - [HUTI_HUMAN] 0.876 1.448 0.731 0.765 1.484 0.743 0.604972376 nan 0.515498652 nan 0.504834254 nan 0.500673854 nan GO:0043648;GO:0019752;GO:0009063;GO:0034641;GO:0006807;GO:0044281;GO:0044282;GO:0009064;GO:0006536;GO:0044699;GO:1901361;GO:0044712;GO:0044710;GO:0006548;GO:0006547;GO:0006520;GO:0071704;GO:1901360;GO:0019556;GO:1901605;GO:1901606;GO:0044238;GO:0009987;GO:0006725;GO:1901575;GO:0046700;GO:0015942;GO:0008150;GO:0008152;GO:0043436;GO:0032787;GO:0009056;GO:0046483;GO:0044248;GO:0043606;GO:1901564;GO:0044270;GO:0006082;GO:0046395;GO:0016054;GO:0044237;GO:0052803;GO:0052805;GO:0043603;GO:0019439;GO:0044763;GO:0019557;GO:1901565; dicarboxylic acid metabolic process;carboxylic acid metabolic process;cellular amino acid catabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;small molecule metabolic process;small molecule catabolic process;glutamine family amino acid metabolic process;glutamate metabolic process;single-organism process;organic cyclic compound catabolic process;single-organism catabolic process;single-organism metabolic process;histidine catabolic process;histidine metabolic process;cellular amino acid metabolic process;organic substance metabolic process;organic cyclic compound metabolic process;histidine catabolic process to glutamate and formamide;alpha-amino acid metabolic process;alpha-amino acid catabolic process;primary metabolic process;cellular process;cellular aromatic compound metabolic process;organic substance catabolic process;heterocycle catabolic process;formate metabolic process;biological_process;metabolic process;oxoacid metabolic process;monocarboxylic acid metabolic process;catabolic process;heterocycle metabolic process;cellular catabolic process;formamide metabolic process;organonitrogen compound metabolic process;cellular nitrogen compound catabolic process;organic acid metabolic process;carboxylic acid catabolic process;organic acid catabolic process;cellular metabolic process;imidazole-containing compound metabolic process;imidazole-containing compound catabolic process;cellular amide metabolic process;aromatic compound catabolic process;single-organism cellular process;histidine catabolic process to glutamate and formate;organonitrogen compound catabolic process; 7;6;5;4;3;4;5;6;7;2;5;4;3;7;6;4;3;4;6;5;6;3;2;4;4;5;8;1;2;5;7;3;4;4;5;4;5;4;6;5;3;5;6;5;5;3;8;5; GO:0044444;GO:0005737;GO:0044424;GO:0005623;GO:0044464;GO:0005622;GO:0005575;GO:0005829; cytoplasmic part;cytoplasm;intracellular part;cell;cell part;intracellular;cellular_component;cytosol; 4;4;3;2;2;3;1;5; GO:0005488;GO:0016787;GO:0003674;GO:0050480;GO:0043169;GO:0016810;GO:0043167;GO:0046872;GO:0003824;GO:0016812; binding;hydrolase activity;molecular_function;imidazolonepropionase activity;cation binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;ion binding;metal ion binding;catalytic activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; 2;3;1;6;4;4;3;5;2;5; K01468 map00340;map01100; Histidine metabolism;Metabolic pathways; IPR006680;IPR005920;IPR011059;IPR032466; Amidohydrolase-related;Imidazolonepropionase;Metal-dependent hydrolase, composite domain;Metal-dependent hydrolase; cytosol Hs22056401 876.0 FQ [F] Nucleotide transport and metabolism;[Q] Secondary metabolites biosynthesis, transport and catabolism; O60268 Uncharacterized protein KIAA0513 OS=Homo sapiens OX=9606 GN=KIAA0513 PE=1 SV=1 - [K0513_HUMAN] 1.022 1.195 0.72 0.862 1.126 2.063 0.855230126 nan 0.765541741 nan 0.60251046 nan 1.832149201 nan GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; nucleus Q9HAZ2 PR domain zinc finger protein 16 OS=Homo sapiens OX=9606 GN=PRDM16 PE=1 SV=3 - [PRD16_HUMAN] 1.199 1.195 0.756 1.197 0.993 0.764 1.00334728 nan 1.205438066 nan 0.632635983 nan 0.7693857 nan GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0007165;GO:0007166;GO:0007167;GO:0002573;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0010604;GO:0009968;GO:0009966;GO:0048869;GO:0010033;GO:0030852;GO:0030853;GO:0048513;GO:0071495;GO:0048518;GO:0048519;GO:0002683;GO:1902680;GO:0044700;GO:0060255;GO:0007178;GO:2001141;GO:1903706;GO:1903707;GO:0007179;GO:0046483;GO:0019827;GO:0044707;GO:0023057;GO:0035019;GO:0071310;GO:0002376;GO:0007154;GO:0019438;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0051254;GO:0010629;GO:0006807;GO:0050789;GO:0097659;GO:0002761;GO:1901576;GO:0002762;GO:0044260;GO:0090101;GO:0016043;GO:0070887;GO:0065007;GO:0071840;GO:0006366;GO:0018130;GO:0050793;GO:0017015;GO:0009889;GO:0044710;GO:0050794;GO:0098727;GO:0008150;GO:0008152;GO:0030097;GO:0034654;GO:0002521;GO:0002520;GO:0016070;GO:0044767;GO:0044271;GO:0015980;GO:0007423;GO:0050896;GO:0045600;GO:0006355;GO:0045638;GO:0010556;GO:0006351;GO:0045333;GO:0010558;GO:0032774;GO:0030154;GO:0070848;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0044699;GO:0009719;GO:0006139;GO:0090287;GO:0000122;GO:0010557;GO:0051241;GO:0090288;GO:0043933;GO:0030851;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0050873;GO:1903506;GO:1903507;GO:0045597;GO:0045596;GO:0045595;GO:0045892;GO:0045893;GO:0090336;GO:0045598;GO:0051093;GO:0071363;GO:0051094;GO:0051253;GO:0051252;GO:0043170;GO:0051239;GO:0071560;GO:0010628;GO:0030099;GO:0048731;GO:1903508;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0060021;GO:0090304;GO:0045444;GO:0006091;GO:0007275;GO:0002682;GO:1903845;GO:1903844;GO:0043467;GO:0006325;GO:0071559;GO:2000112;GO:2000113;GO:0043586;GO:0071704;GO:0010467;GO:0006357;GO:0048534;GO:0010468;GO:0090092;GO:0045935;GO:0045934;GO:0019219;GO:0050872;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0042221;GO:0022008;GO:0030512;GO:0006996;GO:0044238;GO:0055114;GO:0043457;GO:0051276;GO:0007399;GO:0048856;GO:0044237;GO:0045637;GO:1902106;GO:1902105;GO:2000026;GO:0090335;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;myeloid leukocyte differentiation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;response to organic substance;regulation of granulocyte differentiation;negative regulation of granulocyte differentiation;animal organ development;cellular response to endogenous stimulus;positive regulation of biological process;negative regulation of biological process;negative regulation of immune system process;positive regulation of RNA biosynthetic process;single organism signaling;regulation of macromolecule metabolic process;transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of RNA biosynthetic process;regulation of hemopoiesis;negative regulation of hemopoiesis;transforming growth factor beta receptor signaling pathway;heterocycle metabolic process;stem cell population maintenance;single-multicellular organism process;negative regulation of signaling;somatic stem cell population maintenance;cellular response to organic substance;immune system process;cell communication;aromatic compound biosynthetic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;negative regulation of gene expression;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;regulation of myeloid leukocyte differentiation;organic substance biosynthetic process;negative regulation of myeloid leukocyte differentiation;cellular macromolecule metabolic process;negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;cellular component organization;cellular response to chemical stimulus;biological regulation;cellular component organization or biogenesis;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of developmental process;regulation of transforming growth factor beta receptor signaling pathway;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;maintenance of cell number;biological_process;metabolic process;hemopoiesis;nucleobase-containing compound biosynthetic process;leukocyte differentiation;immune system development;RNA metabolic process;single-organism developmental process;cellular nitrogen compound biosynthetic process;energy derivation by oxidation of organic compounds;sensory organ development;response to stimulus;positive regulation of fat cell differentiation;regulation of transcription, DNA-templated;negative regulation of myeloid cell differentiation;regulation of macromolecule biosynthetic process;transcription, DNA-templated;cellular respiration;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cell differentiation;response to growth factor;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;single-organism process;response to endogenous stimulus;nucleobase-containing compound metabolic process;regulation of cellular response to growth factor stimulus;negative regulation of transcription from RNA polymerase II promoter;positive regulation of macromolecule biosynthetic process;negative regulation of multicellular organismal process;negative regulation of cellular response to growth factor stimulus;macromolecular complex subunit organization;granulocyte differentiation;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;brown fat cell differentiation;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;positive regulation of brown fat cell differentiation;regulation of fat cell differentiation;negative regulation of developmental process;cellular response to growth factor stimulus;positive regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;regulation of multicellular organismal process;cellular response to transforming growth factor beta stimulus;positive regulation of gene expression;myeloid cell differentiation;system development;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;palate development;nucleic acid metabolic process;fat cell differentiation;generation of precursor metabolites and energy;multicellular organism development;regulation of immune system process;negative regulation of cellular response to transforming growth factor beta stimulus;regulation of cellular response to transforming growth factor beta stimulus;regulation of generation of precursor metabolites and energy;chromatin organization;response to transforming growth factor beta;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;tongue development;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;hematopoietic or lymphoid organ development;regulation of gene expression;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;white fat cell differentiation;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;neurogenesis;negative regulation of transforming growth factor beta receptor signaling pathway;organelle organization;primary metabolic process;oxidation-reduction process;regulation of cellular respiration;chromosome organization;nervous system development;anatomical structure development;cellular metabolic process;regulation of myeloid cell differentiation;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;regulation of brown fat cell differentiation;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;3;4;5;6;7;5;4;3;4;4;4;4;4;4;7;7;4;4;2;2;3;6;3;4;7;6;4;4;6;4;4;3;3;5;5;2;4;5;3;3;4;4;5;5;3;2;7;6;4;6;4;5;3;4;2;2;7;5;3;6;4;3;3;3;1;2;5;5;6;3;5;3;5;4;4;2;5;6;5;5;6;5;5;6;5;5;4;4;2;4;5;3;4;2;3;4;4;7;5;3;4;4;8;2;2;2;4;7;7;7;4;4;4;6;6;6;5;3;6;3;5;5;4;3;5;5;6;4;7;5;5;5;4;4;4;4;5;6;4;4;3;5;5;5;5;4;6;6;5;3;5;7;4;5;5;5;5;5;7;6;3;5;3;4;4;4;3;6;6;4;3;4;6;5;5;3;3;5;5;5;4;6;3;3; GO:0044444;GO:0043234;GO:0043231;GO:0005829;GO:0044424;GO:0005622;GO:0043227;GO:0005737;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0043226;GO:0017053;GO:0032991;GO:0005575; cytoplasmic part;protein complex;intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular;membrane-bounded organelle;cytoplasm;nucleus;cell part;intracellular organelle;cell;organelle;transcriptional repressor complex;macromolecular complex;cellular_component; 4;3;4;5;3;3;3;4;5;2;3;2;2;4;2;1; GO:0043169;GO:1901363;GO:0003713;GO:0003712;GO:0046872;GO:0000988;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0043565;GO:0097159;GO:0033613;GO:0043167;GO:0008134;GO:0005515; cation binding;heterocyclic compound binding;transcription coactivator activity;transcription cofactor activity;metal ion binding;transcription factor activity, protein binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;sequence-specific DNA binding;organic cyclic compound binding;activating transcription factor binding;ion binding;transcription factor binding;protein binding; 4;3;5;4;5;2;1;2;4;5;3;6;3;5;3;4;3; K22410 IPR001214;IPR013087;IPR030413; SET domain;Zinc finger C2H2-type;Evi1/Prdm16; nucleus Hs11545831_2 2361.0 R [R] General function prediction only; Q6ZP82 Coiled-coil domain-containing protein 141 OS=Homo sapiens OX=9606 GN=CCDC141 PE=1 SV=2 - [CC141_HUMAN] 0.844 1.016 1.363 0.789 1.046 0.382 0.830708661 0.579737056 0.754302103 0.35854902 1.341535433 0.551936671 0.365200765 0.103168467 GO:0021537;GO:0044707;GO:0007275;GO:0006928;GO:0060322;GO:0021885;GO:0021987;GO:0044699;GO:0007417;GO:0022029;GO:0008150;GO:0021799;GO:0016477;GO:0021795;GO:0032502;GO:0032501;GO:0009987;GO:0044767;GO:0021543;GO:0044763;GO:0051642;GO:0051179;GO:0051640;GO:0051641;GO:0040011;GO:0048513;GO:0051674;GO:0007420;GO:0048870;GO:0048856;GO:0007399;GO:0030900;GO:0048731; telencephalon development;single-multicellular organism process;multicellular organism development;movement of cell or subcellular component;head development;forebrain cell migration;cerebral cortex development;single-organism process;central nervous system development;telencephalon cell migration;biological_process;cerebral cortex radially oriented cell migration;cell migration;cerebral cortex cell migration;developmental process;multicellular organismal process;cellular process;single-organism developmental process;pallium development;single-organism cellular process;centrosome localization;localization;organelle localization;cellular localization;locomotion;animal organ development;localization of cell;brain development;cell motility;anatomical structure development;nervous system development;forebrain development;system development; 4;3;4;4;4;5;4;2;5;5;1;6;4;5;2;2;2;3;4;3;5;2;4;3;2;4;3;4;3;3;5;4;4; GO:0043226;GO:0043229;GO:0005737;GO:0005575;GO:0005813;GO:0005815;GO:0044430;GO:0005856;GO:0015630;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0043228;GO:0044424;GO:0044422; organelle;intracellular organelle;cytoplasm;cellular_component;centrosome;microtubule organizing center;cytoskeletal part;cytoskeleton;microtubule cytoskeleton;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;non-membrane-bounded organelle;intracellular part;organelle part; 2;3;4;1;5;5;4;5;6;4;2;2;3;3;3;3;2; IPR007110;IPR013783; Immunoglobulin-like domain;Immunoglobulin-like fold; nucleus Q8NFU7 Methylcytosine dioxygenase TET1 OS=Homo sapiens OX=9606 GN=TET1 PE=1 SV=2 - [TET1_HUMAN] 1.007 1.281 0.868 1.234 0.842 1.151 0.786104606 nan 1.465558195 nan 0.677595628 nan 1.366983373 nan GO:0006479;GO:0033044;GO:0080090;GO:0019222;GO:0031056;GO:0031058;GO:1901362;GO:1901360;GO:0044710;GO:0006304;GO:0010605;GO:0010604;GO:0001826;GO:0001825;GO:0001824;GO:0040029;GO:0016458;GO:0048518;GO:0048519;GO:0016570;GO:0042127;GO:0016571;GO:0010467;GO:0060255;GO:0006366;GO:0031060;GO:0031062;GO:2001141;GO:0055114;GO:0046483;GO:0070988;GO:0019827;GO:0044707;GO:0009790;GO:0019538;GO:0010638;GO:0010639;GO:0019438;GO:0051253;GO:0016568;GO:0016569;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0051254;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0006357;GO:0016043;GO:0065007;GO:0071840;GO:1903308;GO:1903309;GO:0032259;GO:0048646;GO:0018130;GO:0051130;GO:0009889;GO:0050794;GO:0098727;GO:0043412;GO:0043413;GO:0008150;GO:0008152;GO:0044723;GO:0016070;GO:1902679;GO:0044271;GO:0031401;GO:0006355;GO:0010557;GO:0044728;GO:0006351;GO:0048869;GO:0043414;GO:2001252;GO:0010558;GO:2001251;GO:0031936;GO:0031935;GO:0032774;GO:0033043;GO:0051246;GO:0030154;GO:0051129;GO:0051128;GO:0044249;GO:0034641;GO:0009792;GO:0034645;GO:0009653;GO:0044699;GO:0006139;GO:0001701;GO:0051247;GO:0006342;GO:0006346;GO:0043933;GO:0032270;GO:0036211;GO:0031399;GO:0043009;GO:0008284;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0045893;GO:0005975;GO:0035511;GO:0080111;GO:0032268;GO:1901137;GO:1901135;GO:0051252;GO:0010629;GO:0043170;GO:1902680;GO:0008213;GO:0010628;GO:0045944;GO:0070989;GO:1902275;GO:0032502;GO:0031328;GO:0035510;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0009100;GO:0007275;GO:0006486;GO:0006325;GO:0090308;GO:2000112;GO:2000113;GO:0009101;GO:1903508;GO:0071704;GO:0031327;GO:0010556;GO:0045814;GO:0045815;GO:0010468;GO:0045935;GO:0045934;GO:0044267;GO:0019219;GO:0090310;GO:0070085;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0060969;GO:0060968;GO:0006996;GO:0044238;GO:0006493;GO:0051276;GO:0048856;GO:0044237;GO:1903310;GO:1902589;GO:0006259;GO:0034654;GO:0048523;GO:0048522; protein methylation;regulation of chromosome organization;regulation of primary metabolic process;regulation of metabolic process;regulation of histone modification;positive regulation of histone modification;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;DNA modification;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;inner cell mass cell differentiation;blastocyst formation;blastocyst development;regulation of gene expression, epigenetic;gene silencing;positive regulation of biological process;negative regulation of biological process;histone modification;regulation of cell proliferation;histone methylation;gene expression;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of histone methylation;positive regulation of histone methylation;regulation of RNA biosynthetic process;oxidation-reduction process;heterocycle metabolic process;demethylation;stem cell population maintenance;single-multicellular organism process;embryo development;protein metabolic process;positive regulation of organelle organization;negative regulation of organelle organization;aromatic compound biosynthetic process;negative regulation of RNA metabolic process;chromatin modification;covalent chromatin modification;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;cellular component organization;biological regulation;cellular component organization or biogenesis;regulation of chromatin modification;negative regulation of chromatin modification;methylation;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;positive regulation of cellular component organization;regulation of biosynthetic process;regulation of cellular process;maintenance of cell number;macromolecule modification;macromolecule glycosylation;biological_process;metabolic process;single-organism carbohydrate metabolic process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;positive regulation of protein modification process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;DNA methylation or demethylation;transcription, DNA-templated;cellular developmental process;macromolecule methylation;positive regulation of chromosome organization;negative regulation of macromolecule biosynthetic process;negative regulation of chromosome organization;negative regulation of chromatin silencing;regulation of chromatin silencing;RNA biosynthetic process;regulation of organelle organization;regulation of protein metabolic process;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;in utero embryonic development;positive regulation of protein metabolic process;chromatin silencing;methylation-dependent chromatin silencing;macromolecular complex subunit organization;positive regulation of cellular protein metabolic process;protein modification process;regulation of protein modification process;chordate embryonic development;positive regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;carbohydrate metabolic process;oxidative DNA demethylation;DNA demethylation;regulation of cellular protein metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;positive regulation of RNA biosynthetic process;protein alkylation;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;oxidative demethylation;regulation of chromatin organization;developmental process;positive regulation of cellular biosynthetic process;DNA dealkylation;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;glycoprotein metabolic process;multicellular organism development;protein glycosylation;chromatin organization;regulation of methylation-dependent chromatin silencing;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;glycoprotein biosynthetic process;positive regulation of nucleic acid-templated transcription;organic substance metabolic process;negative regulation of cellular biosynthetic process;regulation of macromolecule biosynthetic process;negative regulation of gene expression, epigenetic;positive regulation of gene expression, epigenetic;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of methylation-dependent chromatin silencing;glycosylation;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;negative regulation of gene silencing;regulation of gene silencing;organelle organization;primary metabolic process;protein O-linked glycosylation;chromosome organization;anatomical structure development;cellular metabolic process;positive regulation of chromatin modification;single-organism organelle organization;DNA metabolic process;nucleobase-containing compound biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 5;6;4;3;5;5;5;4;3;6;4;4;5;4;4;6;4;2;2;4;4;5;5;4;7;6;6;6;4;4;4;4;3;5;4;5;5;5;5;6;7;3;3;4;4;5;3;2;7;4;4;7;3;2;2;7;7;3;3;5;4;4;3;3;5;6;1;2;4;5;6;5;6;6;5;7;6;4;4;6;5;6;5;5;6;5;5;5;4;4;4;4;6;5;3;2;4;8;5;5;5;4;5;5;6;7;4;2;3;2;4;7;7;6;6;4;5;4;5;5;4;5;5;4;6;7;5;7;5;6;2;5;7;5;4;4;4;5;5;4;4;5;6;6;6;6;7;3;5;5;6;6;5;5;5;5;5;6;5;6;3;3;5;3;4;4;4;4;4;4;3;5;5;3;3;7;4;5;5;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleus;cell part;cell;cellular_component; 4;3;3;3;3;2;5;2;2;1; GO:0046914;GO:1901363;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043169;GO:0003824;GO:0097159;GO:0016491;GO:0043566;GO:0016706;GO:0016705;GO:0008270;GO:0043167;GO:0070579;GO:0005506;GO:0051213; transition metal ion binding;heterocyclic compound binding;metal ion binding;molecular_function;binding;nucleic acid binding;DNA binding;cation binding;catalytic activity;organic cyclic compound binding;oxidoreductase activity;structure-specific DNA binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;zinc ion binding;ion binding;methylcytosine dioxygenase activity;iron ion binding;dioxygenase activity; 6;3;5;1;2;4;5;4;2;3;3;6;5;4;7;3;6;7;4; K13097 IPR024779;IPR002857; 2OGFeDO, oxygenase domain;Zinc finger, CXXC-type; nucleus P0DJI9 Serum amyloid A-2 protein OS=Homo sapiens OX=9606 GN=SAA2 PE=1 SV=1 - [SAA2_HUMAN] 1.214 1.037 0.962 1.034 0.929 1.052 1.170684667 nan 1.113024758 nan 0.927675988 nan 1.132400431 nan GO:0042221;GO:0060326;GO:0006928;GO:0051674;GO:0050918;GO:0070887;GO:0002526;GO:0044699;GO:0051716;GO:0042330;GO:0016477;GO:0006935;GO:0009987;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0006954;GO:0051179;GO:0040011;GO:0009605;GO:0048870;GO:0050896;GO:0044763; response to chemical;cell chemotaxis;movement of cell or subcellular component;localization of cell;positive chemotaxis;cellular response to chemical stimulus;acute inflammatory response;single-organism process;cellular response to stimulus;taxis;cell migration;chemotaxis;cellular process;defense response;acute-phase response;response to stress;biological_process;inflammatory response;localization;locomotion;response to external stimulus;cell motility;response to stimulus;single-organism cellular process; 3;5;4;3;5;4;6;2;3;3;4;4;2;4;7;3;1;5;2;2;3;3;2;3; GO:0034358;GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0034364;GO:0032991;GO:1903561;GO:0031982;GO:0032994;GO:0043230;GO:0005575;GO:0005576;GO:1990777;GO:0044421; plasma lipoprotein particle;membrane-bounded organelle;organelle;extracellular exosome;extracellular space;high-density lipoprotein particle;macromolecular complex;extracellular vesicle;vesicle;protein-lipid complex;extracellular organelle;cellular_component;extracellular region;lipoprotein particle;extracellular region part; 3;3;2;4;3;4;2;3;4;3;3;1;2;4;2; GO:0042056;GO:0003674; chemoattractant activity;molecular_function; 2;1; K17310 IPR000096; Serum amyloid A protein; extracellular P0DJI8 Serum amyloid A-1 protein OS=Homo sapiens OX=9606 GN=SAA1 PE=1 SV=1 - [SAA1_HUMAN] 1.347 0.577 1.128 1.509 0.569 1.257 2.334488735 4.77E-05 2.65202109 2.59E-06 1.954939341 0.010371627 2.20913884 0.002557195 GO:0032880;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0051047;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0032147;GO:0031348;GO:0007165;GO:0060326;GO:0098771;GO:0044707;GO:0023014;GO:0032652;GO:0051716;GO:0010604;GO:0042330;GO:0045785;GO:0009966;GO:0009967;GO:0000165;GO:0009611;GO:0030168;GO:0044093;GO:0048518;GO:0048519;GO:0002526;GO:0033036;GO:0050801;GO:0007599;GO:0019725;GO:0030595;GO:0007596;GO:0030593;GO:0006935;GO:0051050;GO:0060255;GO:0050918;GO:0045859;GO:0045184;GO:0042221;GO:0051222;GO:0016192;GO:0042325;GO:0044700;GO:0042327;GO:0065008;GO:0009605;GO:0048870;GO:0019538;GO:0007204;GO:0048878;GO:0002376;GO:0051223;GO:0032732;GO:0009893;GO:0033674;GO:0006950;GO:0006928;GO:0032940;GO:0051674;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0044267;GO:1904951;GO:0051347;GO:0044260;GO:0050704;GO:0043549;GO:0050701;GO:0050708;GO:0065007;GO:0043085;GO:0065009;GO:0016477;GO:0070201;GO:0006810;GO:0009306;GO:0050790;GO:0044710;GO:0042060;GO:0050794;GO:0043410;GO:0006953;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:1902533;GO:0031347;GO:1902531;GO:0006952;GO:0046903;GO:0006897;GO:0050715;GO:0050714;GO:0050896;GO:0031401;GO:0072676;GO:0051338;GO:0050817;GO:0051046;GO:0051240;GO:0032102;GO:0006954;GO:0032101;GO:0001775;GO:0016310;GO:0030155;GO:0050727;GO:0023056;GO:0043406;GO:0043405;GO:0023052;GO:1903530;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0043408;GO:0072507;GO:0051234;GO:0055074;GO:0072503;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0001816;GO:0097530;GO:0031399;GO:0022610;GO:1903034;GO:1903035;GO:0032501;GO:0050878;GO:0032612;GO:0006874;GO:0009987;GO:0006873;GO:0050728;GO:0030003;GO:0055080;GO:0055082;GO:0032879;GO:0050716;GO:0042592;GO:0032268;GO:0043170;GO:0051239;GO:0001817;GO:0006875;GO:0045860;GO:0097529;GO:0080134;GO:0001819;GO:0000187;GO:0006898;GO:0050707;GO:0060341;GO:0031325;GO:1990266;GO:0031323;GO:0050900;GO:0048246;GO:0050663;GO:0048247;GO:0071704;GO:0071702;GO:0071621;GO:0006468;GO:0045937;GO:0045087;GO:0006464;GO:0051174;GO:1903532;GO:0044765;GO:0044763;GO:0055065;GO:0007155;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0051480;GO:0044237;GO:0006796;GO:0006793;GO:0015031;GO:0001932;GO:0001934;GO:0048522; regulation of protein localization;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of secretion;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;negative regulation of defense response;signal transduction;cell chemotaxis;inorganic ion homeostasis;single-multicellular organism process;signal transduction by protein phosphorylation;regulation of interleukin-1 production;cellular response to stimulus;positive regulation of macromolecule metabolic process;taxis;positive regulation of cell adhesion;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;response to wounding;platelet activation;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;acute inflammatory response;macromolecule localization;ion homeostasis;hemostasis;cellular homeostasis;leukocyte chemotaxis;blood coagulation;neutrophil chemotaxis;chemotaxis;positive regulation of transport;regulation of macromolecule metabolic process;positive chemotaxis;regulation of protein kinase activity;establishment of protein localization;response to chemical;positive regulation of protein transport;vesicle-mediated transport;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;regulation of biological quality;response to external stimulus;cell motility;protein metabolic process;positive regulation of cytosolic calcium ion concentration;chemical homeostasis;immune system process;regulation of protein transport;positive regulation of interleukin-1 production;positive regulation of metabolic process;positive regulation of kinase activity;response to stress;movement of cell or subcellular component;secretion by cell;localization of cell;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cellular protein metabolic process;positive regulation of establishment of protein localization;positive regulation of transferase activity;cellular macromolecule metabolic process;regulation of interleukin-1 secretion;regulation of kinase activity;interleukin-1 secretion;regulation of protein secretion;biological regulation;positive regulation of catalytic activity;regulation of molecular function;cell migration;regulation of establishment of protein localization;transport;protein secretion;regulation of catalytic activity;single-organism metabolic process;wound healing;regulation of cellular process;positive regulation of MAPK cascade;acute-phase response;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;positive regulation of intracellular signal transduction;regulation of defense response;regulation of intracellular signal transduction;defense response;secretion;endocytosis;positive regulation of cytokine secretion;positive regulation of protein secretion;response to stimulus;positive regulation of protein modification process;lymphocyte migration;regulation of transferase activity;coagulation;regulation of secretion;positive regulation of multicellular organismal process;negative regulation of response to external stimulus;inflammatory response;regulation of response to external stimulus;cell activation;phosphorylation;regulation of cell adhesion;regulation of inflammatory response;positive regulation of signaling;positive regulation of MAP kinase activity;regulation of MAP kinase activity;signaling;regulation of secretion by cell;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MAPK cascade;divalent inorganic cation homeostasis;establishment of localization;calcium ion homeostasis;cellular divalent inorganic cation homeostasis;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;cytokine production;granulocyte migration;regulation of protein modification process;biological adhesion;regulation of response to wounding;negative regulation of response to wounding;multicellular organismal process;regulation of body fluid levels;interleukin-1 production;cellular calcium ion homeostasis;cellular process;cellular ion homeostasis;negative regulation of inflammatory response;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of localization;positive regulation of interleukin-1 secretion;homeostatic process;regulation of cellular protein metabolic process;macromolecule metabolic process;regulation of multicellular organismal process;regulation of cytokine production;cellular metal ion homeostasis;positive regulation of protein kinase activity;myeloid leukocyte migration;regulation of response to stress;positive regulation of cytokine production;activation of MAPK activity;receptor-mediated endocytosis;regulation of cytokine secretion;regulation of cellular localization;positive regulation of cellular metabolic process;neutrophil migration;regulation of cellular metabolic process;leukocyte migration;macrophage chemotaxis;cytokine secretion;lymphocyte chemotaxis;organic substance metabolic process;organic substance transport;granulocyte chemotaxis;protein phosphorylation;positive regulation of phosphate metabolic process;innate immune response;cellular protein modification process;regulation of phosphorus metabolic process;positive regulation of secretion by cell;single-organism transport;single-organism cellular process;metal ion homeostasis;cell adhesion;cell communication;localization;single-organism localization;cellular localization;locomotion;primary metabolic process;regulation of cytosolic calcium ion concentration;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 4;4;6;4;3;4;4;3;3;3;9;4;4;5;7;3;4;5;3;4;3;4;4;4;5;4;5;4;2;2;6;3;6;5;4;4;5;6;4;3;4;5;7;4;3;4;5;7;3;7;3;3;3;4;11;5;2;5;5;3;7;3;4;4;3;9;5;8;2;5;3;6;4;6;6;6;6;2;5;3;4;5;4;5;4;3;5;3;6;7;5;5;1;2;3;5;5;5;4;5;6;5;5;2;6;4;5;4;5;3;4;5;4;4;6;4;5;3;7;7;2;5;4;3;4;4;2;6;8;3;9;8;5;5;5;5;4;5;6;2;5;4;2;4;5;9;2;6;5;7;7;5;3;6;4;5;4;3;4;8;8;4;4;4;8;7;5;4;4;6;4;3;5;5;5;3;5;5;7;6;4;6;5;4;4;3;8;3;4;2;3;3;2;3;10;3;5;4;5;7;7;3; GO:0031974;GO:0099512;GO:0034358;GO:0031983;GO:0031988;GO:0044430;GO:0015630;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:1990777;GO:0044421;GO:0044422;GO:0060205;GO:0043232;GO:0043227;GO:0005856;GO:0044433;GO:0097708;GO:0031982;GO:0071682;GO:0044446;GO:0016023;GO:0044444;GO:0005874;GO:0005737;GO:0005615;GO:0031410;GO:0005881;GO:0032994;GO:0099513;GO:0044464;GO:0043229;GO:0005623;GO:0043228;GO:0030139;GO:0034364;GO:0070062;GO:0043226;GO:0005622;GO:1903561;GO:0032991;GO:0005575;GO:0005576; membrane-enclosed lumen;supramolecular fiber;plasma lipoprotein particle;vesicle lumen;membrane-bounded vesicle;cytoskeletal part;microtubule cytoskeleton;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;lipoprotein particle;extracellular region part;organelle part;cytoplasmic membrane-bounded vesicle lumen;intracellular non-membrane-bounded organelle;membrane-bounded organelle;cytoskeleton;cytoplasmic vesicle part;intracellular vesicle;vesicle;endocytic vesicle lumen;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;microtubule;cytoplasm;extracellular space;cytoplasmic vesicle;cytoplasmic microtubule;protein-lipid complex;polymeric cytoskeletal fiber;cell part;intracellular organelle;cell;non-membrane-bounded organelle;endocytic vesicle;high-density lipoprotein particle;extracellular exosome;organelle;intracellular;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 2;2;3;4;5;4;6;3;4;3;3;4;2;2;5;4;3;5;4;4;4;6;3;5;4;4;4;3;5;5;3;3;2;3;2;3;6;4;4;2;3;3;2;1;2; GO:0097367;GO:0003674;GO:0005488;GO:0043168;GO:0001664;GO:0043167;GO:0008201;GO:0005515;GO:0005102;GO:0042056;GO:1901681;GO:0005539; carbohydrate derivative binding;molecular_function;binding;anion binding;G-protein coupled receptor binding;ion binding;heparin binding;protein binding;receptor binding;chemoattractant activity;sulfur compound binding;glycosaminoglycan binding; 3;1;2;4;5;3;4;3;4;2;3;4; K17310 IPR000096; Serum amyloid A protein; extracellular P06310 Immunoglobulin kappa variable 2-30 OS=Homo sapiens OX=9606 GN=IGKV2-30 PE=3 SV=2 - [KV230_HUMAN] 1.264 0.886 1.177 1.261 0.667 0.971 1.426636569 6.54E-06 1.890554723 9.29E-06 1.328442438 0.003413485 1.455772114 0.004461195 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q96KN2 Beta-Ala-His dipeptidase OS=Homo sapiens OX=9606 GN=CNDP1 PE=1 SV=4 - [CNDP1_HUMAN] 1.144 1.02 0.922 1.14 0.876 0.987 1.121568627 0.019547027 1.301369863 0.004473153 0.903921569 0.892572136 1.126712329 0.190179203 GO:0005575;GO:0005576; cellular_component;extracellular region; 1;2; GO:0016787;GO:0003824;GO:0004180;GO:0016805;GO:0043169;GO:0043167;GO:0008238;GO:0070011;GO:0003674;GO:0005488;GO:0034701;GO:0008233;GO:0046872;GO:0008237; hydrolase activity;catalytic activity;carboxypeptidase activity;dipeptidase activity;cation binding;ion binding;exopeptidase activity;peptidase activity, acting on L-amino acid peptides;molecular_function;binding;tripeptidase activity;peptidase activity;metal ion binding;metallopeptidase activity; 3;2;7;7;4;3;6;5;1;2;7;4;5;6; K05604 map00330;map00340;map00410;map01100; Arginine and proline metabolism;Histidine metabolism;beta-Alanine metabolism;Metabolic pathways; IPR001261;IPR002933;IPR011650;IPR017153; ArgE/DapE/ACY1/CPG2/YscS, conserved site;Peptidase M20;Peptidase M20, dimerisation domain;Cytosolic nonspecific dipeptidase/DUG1; endoplasmic reticulum Hs21071039 1042.0 E [E] Amino acid transport and metabolism; P06312 Immunoglobulin kappa variable 4-1 OS=Homo sapiens OX=9606 GN=IGKV4-1 PE=1 SV=1 - [KV401_HUMAN] 1.058 0.993 1.039 0.899 0.98 0.873 1.065458207 0.332582142 0.917346939 0.101659439 1.04632427 0.01407191 0.890816327 0.442456272 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0002440;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002377;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;production of molecular mediator of immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;immunoglobulin production;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;5;4;4;3;2;3;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;4;3;3;1; GO:0005575;GO:0016020;GO:0072562;GO:0005886;GO:0005615;GO:0071944;GO:0044464;GO:0005623;GO:0005576;GO:0044421; cellular_component;membrane;blood microparticle;plasma membrane;extracellular space;cell periphery;cell part;cell;extracellular region;extracellular region part; 1;2;3;3;3;3;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9H628 Ras-related and estrogen-regulated growth inhibitor-like protein OS=Homo sapiens OX=9606 GN=RERGL PE=2 SV=1 - [RERGL_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0050789;GO:0035556;GO:0051716;GO:0065007;GO:0009987;GO:0050794;GO:0008150;GO:0007154;GO:0007264;GO:0044700;GO:0044699;GO:0050896;GO:0044763;GO:0023052;GO:0007165; regulation of biological process;intracellular signal transduction;cellular response to stimulus;biological regulation;cellular process;regulation of cellular process;biological_process;cell communication;small GTPase mediated signal transduction;single organism signaling;single-organism process;response to stimulus;single-organism cellular process;signaling;signal transduction; 2;5;3;2;2;3;1;4;6;3;2;2;3;2;4; GO:0044464;GO:0016020;GO:0005623;GO:0005622;GO:0005575; cell part;membrane;cell;intracellular;cellular_component; 2;2;2;3;1; GO:0035639;GO:0003674;GO:0005488;GO:0043167;GO:1901363;GO:1901265;GO:0001882;GO:0043168;GO:0000166;GO:0032561;GO:0001883;GO:0032549;GO:0017076;GO:0005525;GO:0036094;GO:0097367;GO:0097159;GO:0019001;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;ion binding;heterocyclic compound binding;nucleoside phosphate binding;nucleoside binding;anion binding;nucleotide binding;guanyl ribonucleotide binding;purine nucleoside binding;ribonucleoside binding;purine nucleotide binding;GTP binding;small molecule binding;carbohydrate derivative binding;organic cyclic compound binding;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;3;3;4;4;4;4;6;5;5;5;6;3;3;3;6;5;6;4; K17198 IPR020849;IPR027417;IPR001806; Small GTPase superfamily, Ras type;P-loop containing nucleoside triphosphate hydrolase;Small GTPase superfamily; cytosol Hs13376046 422.0 R [R] General function prediction only; A0A0A0MT36 Immunoglobulin kappa variable 6D-21 OS=Homo sapiens OX=9606 GN=IGKV6D-21 PE=3 SV=1 - [KVD21_HUMAN] 1.048 0.847 1.274 1.129 0.779 1.254 1.237308146 nan 1.449293967 nan 1.504132231 nan 1.609756098 nan IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q7RTR0 NACHT, LRR and PYD domains-containing protein 9 OS=Homo sapiens OX=9606 GN=NLRP9 PE=1 SV=1 - [NLRP9_HUMAN] 1.144 1.036 0.775 1.19 1.096 0.67 1.104247104 0.39538175 1.085766423 0.298236674 0.748069498 0.013499636 0.611313869 0.004011039 GO:0005737;GO:0044424;GO:0044464;GO:0005623;GO:0005622;GO:0005575; cytoplasm;intracellular part;cell part;cell;intracellular;cellular_component; 4;3;2;2;3;1; GO:0035639;GO:0003674;GO:0005488;GO:0000166;GO:1901363;GO:0001883;GO:0001882;GO:0043167;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0036094;GO:0030554;GO:0097367;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;nucleotide binding;heterocyclic compound binding;purine nucleoside binding;nucleoside binding;ion binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;small molecule binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;4;3;5;4;3;4;5;5;6;4;3;6;3;3;6;5;6;4; K22663 IPR007111;IPR004020;IPR001611;IPR032675;IPR027417;IPR011029; NACHT nucleoside triphosphatase;DAPIN domain;Leucine-rich repeat;Leucine-rich repeat domain, L domain-like;P-loop containing nucleoside triphosphate hydrolase;Death-like domain; cytosol 46446604 85.9 K [K] Transcription; COG4886 Leucine-rich repeat (LRR) protein Q9ULI3 Protein HEG homolog 1 OS=Homo sapiens OX=9606 GN=HEG1 PE=1 SV=3 - [HEG1_HUMAN] 0.701 0.814 1.944 0.832 0.709 0.93 0.861179361 nan 1.17348378 nan 2.388206388 nan 1.311706629 nan GO:0048589;GO:0048468;GO:0072359;GO:0072358;GO:0035264;GO:0035265;GO:0061384;GO:0071840;GO:0061383;GO:0007517;GO:0048869;GO:0048513;GO:0048514;GO:0030855;GO:0048518;GO:0002064;GO:0060541;GO:0003007;GO:0090270;GO:0090271;GO:0003008;GO:0044707;GO:0060419;GO:0003013;GO:0060415;GO:0090269;GO:0022607;GO:0003382;GO:0003017;GO:0003281;GO:0050789;GO:0003205;GO:0001816;GO:0000904;GO:0000902;GO:0001568;GO:0003209;GO:0003208;GO:0016043;GO:0065007;GO:0065008;GO:0048644;GO:0009887;GO:0009888;GO:0008150;GO:0051239;GO:0003230;GO:0003231;GO:0001570;GO:0003158;GO:0030154;GO:0009791;GO:0009790;GO:0009792;GO:0007043;GO:0003229;GO:0061061;GO:0009653;GO:0003222;GO:0044699;GO:0001701;GO:0051240;GO:0001944;GO:0001945;GO:0043009;GO:0032502;GO:0032501;GO:0050878;GO:0055008;GO:0060429;GO:0045216;GO:0034329;GO:0048738;GO:0001817;GO:0048731;GO:0001819;GO:0055017;GO:0030323;GO:0030324;GO:0055010;GO:0034330;GO:0014706;GO:0001885;GO:0001886;GO:0007275;GO:0045446;GO:0040007;GO:0048845;GO:0032989;GO:0048729;GO:0009987;GO:0060039;GO:0044767;GO:0003206;GO:0044763;GO:0035295;GO:0007507;GO:0003279;GO:0048856;GO:0044085;GO:0060537;GO:0060841; developmental growth;cell development;circulatory system development;cardiovascular system development;multicellular organism growth;organ growth;heart trabecula morphogenesis;cellular component organization or biogenesis;trabecula morphogenesis;muscle organ development;cellular developmental process;animal organ development;blood vessel morphogenesis;epithelial cell differentiation;positive regulation of biological process;epithelial cell development;respiratory system development;heart morphogenesis;regulation of fibroblast growth factor production;positive regulation of fibroblast growth factor production;system process;single-multicellular organism process;heart growth;circulatory system process;muscle tissue morphogenesis;fibroblast growth factor production;cellular component assembly;epithelial cell morphogenesis;lymph circulation;ventricular septum development;regulation of biological process;cardiac chamber development;cytokine production;cell morphogenesis involved in differentiation;cell morphogenesis;blood vessel development;cardiac atrium morphogenesis;cardiac ventricle morphogenesis;cellular component organization;biological regulation;regulation of biological quality;muscle organ morphogenesis;organ morphogenesis;tissue development;biological_process;regulation of multicellular organismal process;cardiac atrium development;cardiac ventricle development;vasculogenesis;endothelium development;cell differentiation;post-embryonic development;embryo development;embryo development ending in birth or egg hatching;cell-cell junction assembly;ventricular cardiac muscle tissue development;muscle structure development;anatomical structure morphogenesis;ventricular trabecula myocardium morphogenesis;single-organism process;in utero embryonic development;positive regulation of multicellular organismal process;vasculature development;lymph vessel development;chordate embryonic development;developmental process;multicellular organismal process;regulation of body fluid levels;cardiac muscle tissue morphogenesis;epithelium development;cell-cell junction organization;cell junction assembly;cardiac muscle tissue development;regulation of cytokine production;system development;positive regulation of cytokine production;cardiac muscle tissue growth;respiratory tube development;lung development;ventricular cardiac muscle tissue morphogenesis;cell junction organization;striated muscle tissue development;endothelial cell development;endothelial cell morphogenesis;multicellular organism development;endothelial cell differentiation;growth;venous blood vessel morphogenesis;cellular component morphogenesis;tissue morphogenesis;cellular process;pericardium development;single-organism developmental process;cardiac chamber morphogenesis;single-organism cellular process;tube development;heart development;cardiac septum development;anatomical structure development;cellular component biogenesis;muscle tissue development;venous blood vessel development; 3;4;5;5;4;4;5;2;4;5;4;4;4;6;2;5;5;5;5;5;3;3;5;4;5;5;4;6;5;5;2;4;4;5;5;4;5;5;3;2;3;5;4;4;1;3;5;5;5;6;5;4;5;6;6;6;4;3;6;2;8;3;5;4;7;2;2;4;6;5;5;5;5;4;4;4;4;4;4;6;4;6;6;7;4;7;2;5;4;4;2;5;3;4;3;4;4;4;3;3;5;5; GO:0005911;GO:0016021;GO:0016020;GO:0030054;GO:0044425;GO:0009897;GO:0031224;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0005576;GO:0005886;GO:0005575; cell-cell junction;integral component of membrane;membrane;cell junction;membrane part;external side of plasma membrane;intrinsic component of membrane;plasma membrane part;cell surface;cell part;cell;cell periphery;side of membrane;extracellular region;plasma membrane;cellular_component; 3;4;2;2;2;4;3;3;3;2;2;3;3;2;3;1; GO:0046872;GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509; metal ion binding;molecular_function;binding;cation binding;ion binding;calcium ion binding; 5;1;2;4;3;6; IPR028720;IPR000152;IPR018097;IPR000742;IPR001881;IPR013032; Protein HEG;EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;EGF-like domain;EGF-like calcium-binding domain;EGF-like, conserved site; plasma membrane O95389 WNT1-inducible-signaling pathway protein 3 OS=Homo sapiens OX=9606 GN=WISP3 PE=1 SV=1 - [WISP3_HUMAN] 0.884 1.553 0.557 1.106 1.382 0.486 0.569220863 nan 0.800289436 nan 0.358660657 nan 0.351664255 nan GO:0007155;GO:0008219;GO:0010941;GO:0050789;GO:0044699;GO:0051716;GO:0016049;GO:0040008;GO:0016043;GO:0065007;GO:0071840;GO:0048519;GO:0022610;GO:0060548;GO:0009987;GO:0050794;GO:0051128;GO:0001558;GO:0008150;GO:0023052;GO:0007267;GO:0007154;GO:0040007;GO:0044700;GO:0050896;GO:0044763;GO:0048523;GO:0007165; cell adhesion;cell death;regulation of cell death;regulation of biological process;single-organism process;cellular response to stimulus;cell growth;regulation of growth;cellular component organization;biological regulation;cellular component organization or biogenesis;negative regulation of biological process;biological adhesion;negative regulation of cell death;cellular process;regulation of cellular process;regulation of cellular component organization;regulation of cell growth;biological_process;signaling;cell-cell signaling;cell communication;growth;single organism signaling;response to stimulus;single-organism cellular process;negative regulation of cellular process;signal transduction; 3;4;4;2;2;3;3;3;3;2;2;2;2;4;2;3;4;4;1;2;4;4;2;3;2;3;3;4; GO:0031012;GO:0005615;GO:0005578;GO:0005575;GO:0005576;GO:0044421; extracellular matrix;extracellular space;proteinaceous extracellular matrix;cellular_component;extracellular region;extracellular region part; 2;3;3;1;2;2; GO:0003674;GO:0044877;GO:0005488;GO:0043168;GO:0005539;GO:1901681;GO:0043167;GO:0032403;GO:0005178;GO:0050839;GO:0008201;GO:0097367;GO:0005515;GO:0005102; molecular_function;macromolecular complex binding;binding;anion binding;glycosaminoglycan binding;sulfur compound binding;ion binding;protein complex binding;integrin binding;cell adhesion molecule binding;heparin binding;carbohydrate derivative binding;protein binding;receptor binding; 1;3;2;4;4;3;3;4;5;4;4;3;3;4; K23090 IPR006207;IPR017891;IPR006208;IPR012395;IPR009030;IPR000884;IPR000867; Cystine knot, C-terminal;Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site;Glycoprotein hormone subunit beta;IGFBP-related, CNN;Growth factor receptor cysteine-rich domain;Thrombospondin type-1 (TSP1) repeat;Insulin-like growth factor-binding protein, IGFBP; extracellular Q15751 Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2 - [HERC1_HUMAN] 1.089 1.057 0.998 1.202 0.911 0.897 1.030274361 nan 1.319429199 nan 0.944181646 nan 0.984632272 nan GO:0019222;GO:0048468;GO:0060322;GO:0071840;GO:0048869;GO:0048513;GO:0044093;GO:0021696;GO:0048519;GO:0021694;GO:0021695;GO:0021692;GO:0003008;GO:0044707;GO:0021680;GO:0009894;GO:0009895;GO:0009892;GO:0031175;GO:0050789;GO:0021702;GO:0043547;GO:0051345;GO:0016043;GO:0065007;GO:0044699;GO:0065009;GO:0048646;GO:0006810;GO:0050790;GO:0050794;GO:0008150;GO:0008152;GO:0051234;GO:0051336;GO:0007420;GO:0030154;GO:0044248;GO:0021533;GO:0009653;GO:0043087;GO:0043085;GO:0007417;GO:0021549;GO:0050885;GO:0021953;GO:0032502;GO:0032501;GO:0031330;GO:0022037;GO:0009987;GO:0021697;GO:0048731;GO:0031329;GO:0030030;GO:0031324;GO:0031323;GO:0021575;GO:0050905;GO:0007275;GO:0050877;GO:0010506;GO:0010507;GO:0048666;GO:0030182;GO:0006914;GO:0044767;GO:0044763;GO:0022008;GO:0009056;GO:0051179;GO:0021587;GO:0048699;GO:0007399;GO:0048856;GO:0044237;GO:0030902;GO:0048523; regulation of metabolic process;cell development;head development;cellular component organization or biogenesis;cellular developmental process;animal organ development;positive regulation of molecular function;cerebellar cortex morphogenesis;negative regulation of biological process;cerebellar Purkinje cell layer formation;cerebellar cortex development;cerebellar Purkinje cell layer morphogenesis;system process;single-multicellular organism process;cerebellar Purkinje cell layer development;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;neuron projection development;regulation of biological process;cerebellar Purkinje cell differentiation;positive regulation of GTPase activity;positive regulation of hydrolase activity;cellular component organization;biological regulation;single-organism process;regulation of molecular function;anatomical structure formation involved in morphogenesis;transport;regulation of catalytic activity;regulation of cellular process;biological_process;metabolic process;establishment of localization;regulation of hydrolase activity;brain development;cell differentiation;cellular catabolic process;cell differentiation in hindbrain;anatomical structure morphogenesis;regulation of GTPase activity;positive regulation of catalytic activity;central nervous system development;cerebellum development;neuromuscular process controlling balance;central nervous system neuron differentiation;developmental process;multicellular organismal process;negative regulation of cellular catabolic process;metencephalon development;cellular process;cerebellar cortex formation;system development;regulation of cellular catabolic process;cell projection organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;hindbrain morphogenesis;neuromuscular process;multicellular organism development;neurological system process;regulation of autophagy;negative regulation of autophagy;neuron development;neuron differentiation;autophagy;single-organism developmental process;single-organism cellular process;neurogenesis;catabolic process;localization;cerebellum morphogenesis;generation of neurons;nervous system development;anatomical structure development;cellular metabolic process;hindbrain development;negative regulation of cellular process; 3;4;4;2;4;4;4;4;2;4;4;4;3;3;4;4;4;3;5;2;5;7;6;3;2;2;3;3;4;4;3;1;2;3;5;4;5;4;5;3;6;5;5;4;6;6;2;2;5;4;2;4;4;5;4;4;4;4;5;4;4;4;4;5;6;3;3;3;6;3;2;4;7;5;3;3;4;3; GO:0016020;GO:0005794;GO:0043231;GO:0005829;GO:0044424;GO:0043229;GO:0043227;GO:0012505;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; membrane;Golgi apparatus;intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;membrane-bounded organelle;endomembrane system;cytoplasmic part;cytoplasm;cell part;cell;intracellular;organelle;cellular_component; 2;4;4;5;3;3;3;3;4;4;2;2;3;2;1; GO:0098772;GO:0016740;GO:0005085;GO:0005086;GO:0003674;GO:0019787;GO:0003824;GO:0004842;GO:0016874; molecular function regulator;transferase activity;guanyl-nucleotide exchange factor activity;ARF guanyl-nucleotide exchange factor activity;molecular_function;ubiquitin-like protein transferase activity;catalytic activity;ubiquitin-protein transferase activity;ligase activity; 2;3;3;4;1;4;2;5;3; K10594 map04120; Ubiquitin mediated proteolysis; IPR017986;IPR001680;IPR003877;IPR009091;IPR015943;IPR019775;IPR013320;IPR001870;IPR016186;IPR000569;IPR000408; WD40-repeat-containing domain;WD40 repeat;SPRY domain;Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;Concanavalin A-like lectin/glucanase domain;B30.2/SPRY domain;C-type lectin-like/link domain;HECT domain;Regulator of chromosome condensation, RCC1; nucleus Hs4557026 10039.0 S [S] Function unknown; P23497 Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3 - [SP100_HUMAN] 0.935 0.82 1.324 0.86 1.151 1.021 1.140243902 nan 0.747176368 nan 1.614634146 nan 0.887054735 nan GO:0032880;GO:0033157;GO:2001236;GO:0008104;GO:0019221;GO:0019222;GO:2001233;GO:0051049;GO:0032386;GO:0032387;GO:0048583;GO:0051169;GO:2000113;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0080090;GO:0051716;GO:0032879;GO:0010605;GO:0010604;GO:0070727;GO:0009966;GO:0071840;GO:0043067;GO:0018193;GO:0043433;GO:0044419;GO:0032446;GO:0019058;GO:0048514;GO:0001101;GO:0044092;GO:0048518;GO:0048519;GO:0046483;GO:1903650;GO:1903828;GO:0051051;GO:0060255;GO:0006366;GO:0051091;GO:0044764;GO:0006928;GO:2001141;GO:0010033;GO:0010467;GO:0044700;GO:0065008;GO:0019538;GO:0048870;GO:0010631;GO:0002376;GO:0018205;GO:0007154;GO:0006259;GO:0010629;GO:0019438;GO:0044710;GO:0033036;GO:0044707;GO:0009892;GO:0034645;GO:0009890;GO:0022603;GO:0019080;GO:0019083;GO:0051101;GO:0051100;GO:0051254;GO:0043170;GO:0042981;GO:0050789;GO:0097659;GO:0043542;GO:0044267;GO:0044260;GO:0043900;GO:0071357;GO:0001568;GO:0030330;GO:0016043;GO:0065007;GO:0044033;GO:0060249;GO:0065009;GO:0016477;GO:0048646;GO:0018130;GO:0070201;GO:0034613;GO:0034097;GO:1903649;GO:0051168;GO:0050793;GO:0050792;GO:0035556;GO:0009889;GO:0051224;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0006955;GO:0034654;GO:0046825;GO:0051234;GO:0032897;GO:0016070;GO:1902679;GO:0044271;GO:0043901;GO:0043903;GO:0071345;GO:0050896;GO:0000122;GO:0043412;GO:0006355;GO:0010557;GO:0010556;GO:2000145;GO:0006351;GO:2000146;GO:0000723;GO:0010558;GO:0060337;GO:0006954;GO:1902041;GO:0051239;GO:1902044;GO:0070647;GO:0051649;GO:1903827;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0023051;GO:0051276;GO:0001667;GO:0010646;GO:0048384;GO:0044699;GO:0009893;GO:0006139;GO:0008625;GO:1903900;GO:1903901;GO:0009653;GO:0009891;GO:0001944;GO:0044765;GO:0043392;GO:0046782;GO:0006810;GO:1904950;GO:0010632;GO:0032502;GO:0040011;GO:0006996;GO:0032501;GO:1902582;GO:0044093;GO:0045184;GO:0031323;GO:0043687;GO:0009987;GO:0006725;GO:0040013;GO:1903506;GO:1903507;GO:0006974;GO:0072331;GO:0040012;GO:0045892;GO:0045893;GO:0016925;GO:0006978;GO:0090132;GO:0090130;GO:0042592;GO:0036337;GO:0051090;GO:0051674;GO:0046907;GO:0051253;GO:0051252;GO:1901342;GO:1902680;GO:0006807;GO:0048731;GO:0051098;GO:0033554;GO:1903508;GO:0071346;GO:0032774;GO:0060341;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0097190;GO:0097191;GO:0090304;GO:0016482;GO:0051223;GO:0015031;GO:0008219;GO:0010941;GO:0051241;GO:0007275;GO:0010628;GO:0046826;GO:0001525;GO:0030522;GO:2000112;GO:0045765;GO:0071704;GO:0071310;GO:0006357;GO:0071702;GO:1902578;GO:0046822;GO:0051704;GO:0010633;GO:0010468;GO:0046823;GO:0030336;GO:0032526;GO:0030334;GO:0045935;GO:0045934;GO:1901576;GO:0019219;GO:0045087;GO:0006915;GO:0090317;GO:0006913;GO:0034340;GO:0034341;GO:0044767;GO:0060333;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0042221;GO:0042772;GO:0051179;GO:0042770;GO:0051641;GO:1901700;GO:0044238;GO:0051271;GO:0051270;GO:0010594;GO:0010596;GO:0006611;GO:0048856;GO:0032200;GO:0044237;GO:1902589;GO:2000026;GO:0016032;GO:0033993;GO:0048525;GO:0044403;GO:0006886;GO:0048523;GO:0048522; regulation of protein localization;regulation of intracellular protein transport;regulation of extrinsic apoptotic signaling pathway;protein localization;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of apoptotic signaling pathway;regulation of transport;regulation of intracellular transport;negative regulation of intracellular transport;regulation of response to stimulus;nuclear transport;negative regulation of cellular macromolecule biosynthetic process;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of primary metabolic process;cellular response to stimulus;regulation of localization;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;regulation of signal transduction;cellular component organization or biogenesis;regulation of programmed cell death;peptidyl-amino acid modification;negative regulation of sequence-specific DNA binding transcription factor activity;interspecies interaction between organisms;protein modification by small protein conjugation;viral life cycle;blood vessel morphogenesis;response to acid chemical;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;heterocycle metabolic process;negative regulation of cytoplasmic transport;negative regulation of cellular protein localization;negative regulation of transport;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;positive regulation of sequence-specific DNA binding transcription factor activity;multi-organism cellular process;movement of cell or subcellular component;regulation of RNA biosynthetic process;response to organic substance;gene expression;single organism signaling;regulation of biological quality;protein metabolic process;cell motility;epithelial cell migration;immune system process;peptidyl-lysine modification;cell communication;DNA metabolic process;negative regulation of gene expression;aromatic compound biosynthetic process;single-organism metabolic process;macromolecule localization;single-multicellular organism process;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;regulation of anatomical structure morphogenesis;viral gene expression;viral transcription;regulation of DNA binding;negative regulation of binding;positive regulation of RNA metabolic process;macromolecule metabolic process;regulation of apoptotic process;regulation of biological process;nucleic acid-templated transcription;endothelial cell migration;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of multi-organism process;cellular response to type I interferon;blood vessel development;DNA damage response, signal transduction by p53 class mediator;cellular component organization;biological regulation;multi-organism metabolic process;anatomical structure homeostasis;regulation of molecular function;cell migration;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;regulation of establishment of protein localization;cellular protein localization;response to cytokine;regulation of cytoplasmic transport;nuclear export;regulation of developmental process;regulation of viral process;intracellular signal transduction;regulation of biosynthetic process;negative regulation of protein transport;regulation of cellular process;defense response;programmed cell death;response to stress;protein modification process;biological_process;cellular protein modification process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;regulation of protein export from nucleus;establishment of localization;negative regulation of viral transcription;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;negative regulation of multi-organism process;regulation of symbiosis, encompassing mutualism through parasitism;cellular response to cytokine stimulus;response to stimulus;negative regulation of transcription from RNA polymerase II promoter;macromolecule modification;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;regulation of cell motility;transcription, DNA-templated;negative regulation of cell motility;telomere maintenance;negative regulation of macromolecule biosynthetic process;type I interferon signaling pathway;inflammatory response;regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of multicellular organismal process;regulation of Fas signaling pathway;protein modification by small protein conjugation or removal;establishment of localization in cell;regulation of cellular protein localization;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;regulation of signaling;chromosome organization;ameboidal-type cell migration;regulation of cell communication;retinoic acid receptor signaling pathway;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;extrinsic apoptotic signaling pathway via death domain receptors;regulation of viral life cycle;negative regulation of viral life cycle;anatomical structure morphogenesis;positive regulation of biosynthetic process;vasculature development;single-organism transport;negative regulation of DNA binding;regulation of viral transcription;transport;negative regulation of establishment of protein localization;regulation of epithelial cell migration;developmental process;locomotion;organelle organization;multicellular organismal process;single-organism intracellular transport;positive regulation of molecular function;establishment of protein localization;regulation of cellular metabolic process;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;negative regulation of locomotion;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;signal transduction by p53 class mediator;regulation of locomotion;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;protein sumoylation;DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;epithelium migration;tissue migration;homeostatic process;Fas signaling pathway;regulation of sequence-specific DNA binding transcription factor activity;localization of cell;intracellular transport;negative regulation of RNA metabolic process;regulation of RNA metabolic process;regulation of vasculature development;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;system development;regulation of binding;cellular response to stress;positive regulation of nucleic acid-templated transcription;cellular response to interferon-gamma;RNA biosynthetic process;regulation of cellular localization;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;nucleic acid metabolic process;cytosolic transport;regulation of protein transport;protein transport;cell death;regulation of cell death;negative regulation of multicellular organismal process;multicellular organism development;positive regulation of gene expression;negative regulation of protein export from nucleus;angiogenesis;intracellular receptor signaling pathway;regulation of cellular macromolecule biosynthetic process;regulation of angiogenesis;organic substance metabolic process;cellular response to organic substance;regulation of transcription from RNA polymerase II promoter;organic substance transport;single-organism localization;regulation of nucleocytoplasmic transport;multi-organism process;negative regulation of epithelial cell migration;regulation of gene expression;negative regulation of nucleocytoplasmic transport;negative regulation of cell migration;response to retinoic acid;regulation of cell migration;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;innate immune response;apoptotic process;negative regulation of intracellular protein transport;nucleocytoplasmic transport;response to type I interferon;response to interferon-gamma;single-organism developmental process;interferon-gamma-mediated signaling pathway;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;DNA damage response, signal transduction resulting in transcription;localization;signal transduction in response to DNA damage;cellular localization;response to oxygen-containing compound;primary metabolic process;negative regulation of cellular component movement;regulation of cellular component movement;regulation of endothelial cell migration;negative regulation of endothelial cell migration;protein export from nucleus;anatomical structure development;telomere organization;cellular metabolic process;single-organism organelle organization;regulation of multicellular organismal development;viral process;response to lipid;negative regulation of viral process;symbiosis, encompassing mutualism through parasitism;intracellular protein transport;negative regulation of cellular process;positive regulation of cellular process; 4;6;6;4;6;3;5;4;5;4;3;6;6;5;5;4;5;5;4;4;3;3;4;4;4;4;2;5;7;5;3;8;5;4;4;4;2;2;4;5;3;3;4;7;5;3;4;6;4;5;3;3;4;3;6;2;8;4;5;5;5;3;3;3;3;5;4;4;4;5;5;5;5;4;6;2;7;7;5;4;3;6;4;7;3;2;3;5;3;4;3;5;5;5;5;6;8;3;4;5;4;4;3;4;5;3;5;1;6;2;3;5;7;3;6;5;6;5;3;4;6;2;7;5;6;5;5;4;6;4;4;5;7;5;7;3;5;7;4;5;4;4;2;4;3;5;5;4;6;2;3;4;7;5;5;3;4;5;4;6;6;4;3;4;2;2;4;2;5;4;4;4;7;2;4;3;7;7;5;6;3;6;6;9;8;5;4;4;6;4;3;5;5;5;5;6;3;4;4;4;7;6;6;4;5;5;5;4;4;5;6;5;6;5;5;4;4;3;4;5;5;4;5;6;5;3;5;7;5;3;7;2;4;5;6;5;5;5;5;5;4;5;4;6;4;7;5;5;3;7;3;5;3;4;4;4;3;7;2;6;3;4;3;4;4;5;5;6;3;6;3;4;4;4;5;4;4;6;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0000781;GO:0043229;GO:0043228;GO:0000228;GO:0016605;GO:0016604;GO:0005654;GO:0034399;GO:0098687;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044454;GO:0044451;GO:0044464;GO:0005623;GO:0005622;GO:0000784;GO:0043227;GO:0043226;GO:0005694;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;chromosome, telomeric region;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome;PML body;nuclear body;nucleoplasm;nuclear periphery;chromosomal region;intracellular organelle part;cytoplasm;nucleolus;nucleus;nuclear chromosome part;nucleoplasm part;cell part;cell;intracellular;nuclear chromosome, telomeric region;membrane-bounded organelle;organelle;chromosome;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;4;2;6;3;3;5;7;6;5;5;5;3;4;5;5;5;5;2;2;3;6;3;2;5;1;4; GO:1901363;GO:0003714;GO:0003713;GO:0008134;GO:0019900;GO:0019904;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0000988;GO:0097159;GO:0046983;GO:0019899;GO:0003712;GO:0070087;GO:0042802;GO:0042803;GO:0005515; heterocyclic compound binding;transcription corepressor activity;transcription coactivator activity;transcription factor binding;kinase binding;protein domain specific binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;organic cyclic compound binding;protein dimerization activity;enzyme binding;transcription cofactor activity;chromo shadow domain binding;identical protein binding;protein homodimerization activity;protein binding; 3;5;5;4;5;4;1;2;4;5;3;2;3;4;4;4;5;4;5;3; K15413 map05168;map05203; Herpes simplex infection;Viral carcinogenesis; IPR010919;IPR000770;IPR009071;IPR004865; SAND domain-like;SAND domain;High mobility group box domain;HSR domain; nucleus Hs19923236_1 1449.0 O [O] Posttranslational modification, protein turnover, chaperones; O14559 Rho GTPase-activating protein 33 OS=Homo sapiens OX=9606 GN=ARHGAP33 PE=1 SV=2 - [RHG33_HUMAN] 1.024 0.946 0.797 1.143 0.894 2.584 1.082452431 nan 1.27852349 nan 0.842494715 nan 2.890380313 nan GO:0008104;GO:0051234;GO:0048583;GO:0023052;GO:0007165;GO:0023051;GO:0035556;GO:0010646;GO:0050789;GO:0044699;GO:0051716;GO:1902531;GO:0009966;GO:0065007;GO:0006810;GO:0071702;GO:0033036;GO:0051056;GO:0015031;GO:0009987;GO:0050794;GO:0045184;GO:0008150;GO:0007154;GO:0007264;GO:0051179;GO:0044700;GO:0050896;GO:0044763; protein localization;establishment of localization;regulation of response to stimulus;signaling;signal transduction;regulation of signaling;intracellular signal transduction;regulation of cell communication;regulation of biological process;single-organism process;cellular response to stimulus;regulation of intracellular signal transduction;regulation of signal transduction;biological regulation;transport;organic substance transport;macromolecule localization;regulation of small GTPase mediated signal transduction;protein transport;cellular process;regulation of cellular process;establishment of protein localization;biological_process;cell communication;small GTPase mediated signal transduction;localization;single organism signaling;response to stimulus;single-organism cellular process; 4;3;3;2;4;3;5;4;2;2;3;5;4;2;4;5;3;6;5;2;3;4;1;4;6;2;3;2;3; GO:0005622;GO:0044464;GO:0005623;GO:0005737;GO:0005575;GO:0044444;GO:0044424;GO:0005829; intracellular;cell part;cell;cytoplasm;cellular_component;cytoplasmic part;intracellular part;cytosol; 3;2;2;4;1;4;3;5; GO:0003674;GO:0098772;GO:0008047;GO:0043168;GO:0005543;GO:0043167;GO:0030234;GO:0005096;GO:0008289;GO:0030695;GO:0060589;GO:0035091;GO:0005488; molecular_function;molecular function regulator;enzyme activator activity;anion binding;phospholipid binding;ion binding;enzyme regulator activity;GTPase activator activity;lipid binding;GTPase regulator activity;nucleoside-triphosphatase regulator activity;phosphatidylinositol binding;binding; 1;2;4;4;4;3;3;5;3;5;4;5;2; K17933 IPR001452;IPR001683;IPR000198;IPR008936;IPR035510; SH3 domain;Phox homologous domain;Rho GTPase-activating protein domain;Rho GTPase activation protein;Rho GTPase-activating protein 33; nucleus Hs20546065 1680.0 T [T] Signal transduction mechanisms; Q86TC9 Myopalladin OS=Homo sapiens OX=9606 GN=MYPN PE=1 SV=2 - [MYPN_HUMAN] 1.059 1.203 1.009 0.943 0.94 1.1 0.880299252 nan 1.003191489 nan 0.838736492 nan 1.170212766 nan GO:0022607;GO:0031032;GO:0030154;GO:0048468;GO:0030036;GO:0010927;GO:0051146;GO:0061061;GO:0009653;GO:0044699;GO:0048869;GO:0016043;GO:0032989;GO:0071840;GO:0048646;GO:0032502;GO:0055001;GO:0055002;GO:0030029;GO:0030239;GO:0009987;GO:0044767;GO:0008150;GO:1902589;GO:0070925;GO:0048856;GO:0006996;GO:0007010;GO:0045214;GO:0044085;GO:0044763;GO:0042692; cellular component assembly;actomyosin structure organization;cell differentiation;cell development;actin cytoskeleton organization;cellular component assembly involved in morphogenesis;striated muscle cell differentiation;muscle structure development;anatomical structure morphogenesis;single-organism process;cellular developmental process;cellular component organization;cellular component morphogenesis;cellular component organization or biogenesis;anatomical structure formation involved in morphogenesis;developmental process;muscle cell development;striated muscle cell development;actin filament-based process;myofibril assembly;cellular process;single-organism developmental process;biological_process;single-organism organelle organization;organelle assembly;anatomical structure development;organelle organization;cytoskeleton organization;sarcomere organization;cellular component biogenesis;single-organism cellular process;muscle cell differentiation; 4;6;5;4;5;4;6;4;3;2;4;3;4;2;3;2;5;6;4;5;2;3;1;4;5;3;4;5;6;3;3;5; GO:0030016;GO:0030017;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0031674;GO:0030018;GO:0043292;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422;GO:0044449; myofibril;sarcomere;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;I band;Z disc;contractile fiber;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part;contractile fiber part; 6;4;3;3;3;2;4;5;4;4;5;4;4;2;2;3;1;4;3;2;3; GO:0017124;GO:0003674;GO:0005488;GO:0042805;GO:0051393;GO:0019904;GO:0008092;GO:0051371;GO:0005515; SH3 domain binding;molecular_function;binding;actinin binding;alpha-actinin binding;protein domain specific binding;cytoskeletal protein binding;muscle alpha-actinin binding;protein binding; 5;1;2;5;6;4;4;7;3; K22028 IPR003599;IPR007110;IPR013783;IPR013098;IPR003598; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin I-set;Immunoglobulin subtype 2; nucleus 182412676 69.7 S [S] Function unknown; COG3291 PKD repeat Q7L985 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 OS=Homo sapiens OX=9606 GN=LINGO2 PE=2 SV=1 - [LIGO2_HUMAN] 1.391 1.192 0.721 1.161 1.08 nan 1.166946309 nan 1.075 nan 0.604865772 nan nan nan GO:0051130;GO:0050808;GO:0050803;GO:0050807;GO:0051128;GO:0022607;GO:0071840;GO:0007275;GO:0044699;GO:0051963;GO:0044087;GO:0051240;GO:0016043;GO:0050789;GO:0044085;GO:0065007;GO:0007416;GO:0048518;GO:0065008;GO:0032502;GO:0032501;GO:0050793;GO:0009987;GO:0050794;GO:0044767;GO:0008150;GO:0051239;GO:0048731;GO:0044707;GO:0007399;GO:0051094;GO:0048856;GO:0044763;GO:0051962;GO:0051960;GO:2000026;GO:0051965;GO:0048522;GO:0044089; positive regulation of cellular component organization;synapse organization;regulation of synapse structure or activity;regulation of synapse organization;regulation of cellular component organization;cellular component assembly;cellular component organization or biogenesis;multicellular organism development;single-organism process;regulation of synapse assembly;regulation of cellular component biogenesis;positive regulation of multicellular organismal process;cellular component organization;regulation of biological process;cellular component biogenesis;biological regulation;synapse assembly;positive regulation of biological process;regulation of biological quality;developmental process;multicellular organismal process;regulation of developmental process;cellular process;regulation of cellular process;single-organism developmental process;biological_process;regulation of multicellular organismal process;system development;single-multicellular organism process;nervous system development;positive regulation of developmental process;anatomical structure development;single-organism cellular process;positive regulation of nervous system development;regulation of nervous system development;regulation of multicellular organismal development;positive regulation of synapse assembly;positive regulation of cellular process;positive regulation of cellular component biogenesis; 4;4;4;5;4;4;2;4;2;4;3;3;3;2;3;2;5;2;3;2;2;3;2;3;3;1;3;4;3;5;3;3;3;4;5;4;4;3;3; GO:0031224;GO:0016020;GO:0005575;GO:0044425;GO:0016021; intrinsic component of membrane;membrane;cellular_component;membrane part;integral component of membrane; 3;2;1;2;4; K23533 IPR003599;IPR003598;IPR013783;IPR013098;IPR032675;IPR003591;IPR001611;IPR007110;IPR000372; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;Immunoglobulin I-set;Leucine-rich repeat domain, L domain-like;Leucine-rich repeat, typical subtype;Leucine-rich repeat;Immunoglobulin-like domain;Leucine-rich repeat N-terminal domain; endoplasmic reticulum Hs18571999 1249.0 R [R] General function prediction only; Q8NCM8 Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC2H1 PE=1 SV=4 - [DYHC2_HUMAN] 1.072 0.935 1.132 0.965 0.916 1.384 1.146524064 0.434109028 1.05349345 0.702291 1.210695187 0.146320094 1.510917031 0.064404519 GO:0048646;GO:0008105;GO:0008104;GO:0021515;GO:0021517;GO:0048584;GO:0035107;GO:0008589;GO:0061024;GO:0072359;GO:0035108;GO:0007165;GO:0007166;GO:1901576;GO:0032989;GO:0071840;GO:0051716;GO:0070727;GO:0009966;GO:0009967;GO:0007368;GO:0010256;GO:0048513;GO:0048518;GO:0033036;GO:0031503;GO:0021522;GO:0030154;GO:0002504;GO:0048583;GO:0021510;GO:0045184;GO:0010970;GO:0002495;GO:0016192;GO:0044700;GO:0044707;GO:0044249;GO:0019538;GO:0002376;GO:0072358;GO:0098840;GO:0044782;GO:0022607;GO:0009101;GO:0060173;GO:0006928;GO:0048002;GO:0043170;GO:0050789;GO:0044267;GO:0010646;GO:0006888;GO:0000902;GO:0044260;GO:0001568;GO:0016043;GO:0065007;GO:0019882;GO:0042384;GO:0019884;GO:0060271;GO:0006810;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0051234;GO:0009953;GO:0007420;GO:0046907;GO:0007224;GO:0050896;GO:0009058;GO:0043413;GO:0048869;GO:0018196;GO:0051649;GO:0042073;GO:0010927;GO:0023056;GO:0009790;GO:0023052;GO:0018193;GO:0034645;GO:0023051;GO:0009799;GO:0010647;GO:0009653;GO:0044699;GO:0007417;GO:0070925;GO:0001944;GO:0030705;GO:0060322;GO:0006508;GO:0021953;GO:0032502;GO:0032501;GO:0044238;GO:0043687;GO:0009987;GO:0016485;GO:0005975;GO:0032990;GO:0007030;GO:0051604;GO:1901137;GO:1901135;GO:0048731;GO:0048736;GO:0019886;GO:0030326;GO:0030030;GO:0030031;GO:0045880;GO:0060976;GO:0009100;GO:0007275;GO:0003002;GO:0007389;GO:0006486;GO:0006487;GO:0002478;GO:0071704;GO:0010467;GO:0044085;GO:0035721;GO:0071702;GO:0018279;GO:0048598;GO:0030182;GO:0048193;GO:0034613;GO:0070085;GO:0006464;GO:0044767;GO:0044765;GO:0009059;GO:0044763;GO:0035113;GO:0007154;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0007507;GO:0048699;GO:0007017;GO:0048858;GO:0007399;GO:0048856;GO:0007018;GO:0044237;GO:1902589;GO:0030900;GO:0009855;GO:0015031;GO:1902582;GO:0006886;GO:0048522; anatomical structure formation involved in morphogenesis;asymmetric protein localization;protein localization;cell differentiation in spinal cord;ventral spinal cord development;positive regulation of response to stimulus;appendage morphogenesis;regulation of smoothened signaling pathway;membrane organization;circulatory system development;limb morphogenesis;signal transduction;cell surface receptor signaling pathway;organic substance biosynthetic process;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;cellular macromolecule localization;regulation of signal transduction;positive regulation of signal transduction;determination of left/right symmetry;endomembrane system organization;animal organ development;positive regulation of biological process;macromolecule localization;protein complex localization;spinal cord motor neuron differentiation;cell differentiation;antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;regulation of response to stimulus;spinal cord development;establishment of protein localization;establishment of localization by movement along microtubule;antigen processing and presentation of peptide antigen via MHC class II;vesicle-mediated transport;single organism signaling;single-multicellular organism process;cellular biosynthetic process;protein metabolic process;immune system process;cardiovascular system development;protein transport along microtubule;cilium organization;cellular component assembly;glycoprotein biosynthetic process;limb development;movement of cell or subcellular component;antigen processing and presentation of peptide antigen;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;regulation of cell communication;ER to Golgi vesicle-mediated transport;cell morphogenesis;cellular macromolecule metabolic process;blood vessel development;cellular component organization;biological regulation;antigen processing and presentation;cilium assembly;antigen processing and presentation of exogenous antigen;cilium morphogenesis;transport;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;dorsal/ventral pattern formation;brain development;intracellular transport;smoothened signaling pathway;response to stimulus;biosynthetic process;macromolecule glycosylation;cellular developmental process;peptidyl-asparagine modification;establishment of localization in cell;intraciliary transport;cellular component assembly involved in morphogenesis;positive regulation of signaling;embryo development;signaling;peptidyl-amino acid modification;cellular macromolecule biosynthetic process;regulation of signaling;specification of symmetry;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;central nervous system development;organelle assembly;vasculature development;cytoskeleton-dependent intracellular transport;head development;proteolysis;central nervous system neuron differentiation;developmental process;multicellular organismal process;primary metabolic process;post-translational protein modification;cellular process;protein processing;carbohydrate metabolic process;cell part morphogenesis;Golgi organization;protein maturation;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;system development;appendage development;antigen processing and presentation of exogenous peptide antigen via MHC class II;embryonic limb morphogenesis;cell projection organization;cell projection assembly;positive regulation of smoothened signaling pathway;coronary vasculature development;glycoprotein metabolic process;multicellular organism development;regionalization;pattern specification process;protein glycosylation;protein N-linked glycosylation;antigen processing and presentation of exogenous peptide antigen;organic substance metabolic process;gene expression;cellular component biogenesis;intraciliary retrograde transport;organic substance transport;protein N-linked glycosylation via asparagine;embryonic morphogenesis;neuron differentiation;Golgi vesicle transport;cellular protein localization;glycosylation;cellular protein modification process;single-organism developmental process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;embryonic appendage morphogenesis;cell communication;neurogenesis;localization;single-organism localization;cellular localization;organelle organization;heart development;generation of neurons;microtubule-based process;cell projection morphogenesis;nervous system development;anatomical structure development;microtubule-based movement;cellular metabolic process;single-organism organelle organization;forebrain development;determination of bilateral symmetry;protein transport;single-organism intracellular transport;intracellular protein transport;positive regulation of cellular process; 3;5;4;6;4;3;4;5;4;5;5;4;5;4;4;2;3;4;4;4;7;4;4;2;3;5;5;5;4;3;5;4;4;5;5;3;3;4;4;2;5;5;5;4;6;5;4;4;4;2;5;4;7;5;4;4;3;2;3;5;4;6;4;3;3;5;5;1;2;4;3;6;4;5;6;2;3;6;4;8;4;6;4;3;5;2;7;5;3;5;4;3;2;5;5;5;6;4;5;6;2;2;3;7;2;6;4;5;5;5;5;4;4;4;6;6;4;5;5;5;5;4;5;4;4;5;5;3;5;3;7;5;6;4;6;6;5;5;6;3;4;5;3;5;4;6;2;3;3;4;4;7;4;5;5;3;5;3;4;4;6;5;5;6;3; GO:0099512;GO:0099513;GO:0031982;GO:0016020;GO:0031512;GO:1902494;GO:0042995;GO:0043234;GO:0043230;GO:0043232;GO:0005829;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0030286;GO:0043227;GO:0044441;GO:0005856;GO:0044430;GO:0005886;GO:0012505;GO:0005930;GO:0044446;GO:0044444;GO:0097014;GO:0005874;GO:0005875;GO:0005737;GO:0045177;GO:0097542;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0005794;GO:0071944;GO:0072372;GO:0070062;GO:0043226;GO:0015630;GO:1903561;GO:0032991;GO:0005575;GO:0005576; supramolecular fiber;polymeric cytoskeletal fiber;vesicle;membrane;motile primary cilium;catalytic complex;cell projection;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;dynein complex;membrane-bounded organelle;ciliary part;cytoskeleton;cytoskeletal part;plasma membrane;endomembrane system;axoneme;intracellular organelle part;cytoplasmic part;ciliary plasm;microtubule;microtubule associated complex;cytoplasm;apical part of cell;ciliary tip;cell projection part;cell part;cell;intracellular;Golgi apparatus;cell periphery;primary cilium;extracellular exosome;organelle;microtubule cytoskeleton;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 2;3;4;2;5;4;3;3;3;4;5;4;3;2;2;3;3;3;5;3;3;5;4;3;3;4;3;4;4;4;4;4;3;4;3;2;2;3;4;3;4;4;2;6;3;2;1;2; GO:1901363;GO:0000166;GO:0016818;GO:0016817;GO:0097367;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0005524;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0030554;GO:0001882;GO:0001883;GO:0017111;GO:0043167;GO:0043168; heterocyclic compound binding;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;carbohydrate derivative binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATP binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;adenyl nucleotide binding;nucleoside binding;purine nucleoside binding;nucleoside-triphosphatase activity;ion binding;anion binding; 3;4;5;4;3;1;2;8;4;6;5;5;8;9;3;2;3;3;6;6;5;6;4;5;6;4;5;7;3;4; K10414 map04145;map04962;map05132; Phagosome;Vasopressin-regulated water reabsorption;Salmonella infection; IPR011704;IPR004273;IPR035699;IPR027417;IPR013594;IPR013602;IPR024743;IPR026815;IPR035706;IPR026983;IPR003593;IPR024317; ATPase, dynein-related, AAA domain;Dynein heavy chain domain;Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;P-loop containing nucleoside triphosphate hydrolase;Dynein heavy chain, domain-1;Dynein heavy chain, domain-2;Dynein heavy chain, coiled coil stalk;Cytoplasmic dynein 2 heavy chain 1;Dynein heavy chain, ATP-binding dynein motor region D5;Dynein heavy chain;AAA+ ATPase domain;Dynein heavy chain, AAA module D4; cytosol Hs18604727 4821.0 Z [Z] Cytoskeleton; Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2 - [SAMH1_HUMAN] 1.226 0.594 0.714 1.562 0.982 1.864 2.063973064 nan 1.590631365 nan 1.202020202 nan 1.898167006 nan GO:0019221;GO:0051289;GO:0048583;GO:0009166;GO:0007165;GO:0007166;GO:0071840;GO:0046434;GO:0044712;GO:0051716;GO:0043207;GO:0009615;GO:0009217;GO:0002682;GO:0046483;GO:0009204;GO:0009200;GO:1901564;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0009607;GO:0009605;GO:0046060;GO:0002376;GO:0044281;GO:0022607;GO:0009141;GO:0009143;GO:0009144;GO:0009146;GO:0006807;GO:0006195;GO:0050789;GO:0006793;GO:0006163;GO:1901575;GO:0071357;GO:0006203;GO:0016043;GO:0065003;GO:0065007;GO:0031347;GO:0019637;GO:1901361;GO:0034097;GO:0009394;GO:0009155;GO:0044710;GO:0009151;GO:0050794;GO:0006952;GO:0019439;GO:0006950;GO:0009262;GO:0008150;GO:0009264;GO:0008152;GO:0006955;GO:0034655;GO:0046700;GO:0051607;GO:0071345;GO:0050896;GO:1901292;GO:0009117;GO:0006753;GO:1901565;GO:0070271;GO:0044248;GO:0034641;GO:0046061;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0006139;GO:0046386;GO:0009987;GO:0006725;GO:0046070;GO:0098542;GO:0055086;GO:0044270;GO:0051259;GO:0050776;GO:1901136;GO:1901135;GO:0080134;GO:0043933;GO:0072521;GO:0072523;GO:0071822;GO:1901360;GO:0051260;GO:0051262;GO:0071704;GO:0071310;GO:0045088;GO:0045087;GO:0006461;GO:0034340;GO:0044763;GO:0060337;GO:0007154;GO:0009056;GO:0044238;GO:0044237;GO:0019692;GO:0006796;GO:0044085;GO:0002252;GO:0009215; cytokine-mediated signaling pathway;protein homotetramerization;regulation of response to stimulus;nucleotide catabolic process;signal transduction;cell surface receptor signaling pathway;cellular component organization or biogenesis;organophosphate catabolic process;single-organism catabolic process;cellular response to stimulus;response to external biotic stimulus;response to virus;purine deoxyribonucleoside triphosphate catabolic process;regulation of immune system process;heterocycle metabolic process;deoxyribonucleoside triphosphate catabolic process;deoxyribonucleoside triphosphate metabolic process;organonitrogen compound metabolic process;response to other organism;response to organic substance;multi-organism process;single organism signaling;response to biotic stimulus;response to external stimulus;dATP metabolic process;immune system process;small molecule metabolic process;cellular component assembly;nucleoside triphosphate metabolic process;nucleoside triphosphate catabolic process;purine nucleoside triphosphate metabolic process;purine nucleoside triphosphate catabolic process;nitrogen compound metabolic process;purine nucleotide catabolic process;regulation of biological process;phosphorus metabolic process;purine nucleotide metabolic process;organic substance catabolic process;cellular response to type I interferon;dGTP catabolic process;cellular component organization;macromolecular complex assembly;biological regulation;regulation of defense response;organophosphate metabolic process;organic cyclic compound catabolic process;response to cytokine;2'-deoxyribonucleotide metabolic process;purine deoxyribonucleotide catabolic process;single-organism metabolic process;purine deoxyribonucleotide metabolic process;regulation of cellular process;defense response;aromatic compound catabolic process;response to stress;deoxyribonucleotide metabolic process;biological_process;deoxyribonucleotide catabolic process;metabolic process;immune response;nucleobase-containing compound catabolic process;heterocycle catabolic process;defense response to virus;cellular response to cytokine stimulus;response to stimulus;nucleoside phosphate catabolic process;nucleotide metabolic process;nucleoside phosphate metabolic process;organonitrogen compound catabolic process;protein complex biogenesis;cellular catabolic process;cellular nitrogen compound metabolic process;dATP catabolic process;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;nucleobase-containing compound metabolic process;deoxyribose phosphate catabolic process;cellular process;cellular aromatic compound metabolic process;dGTP metabolic process;defense response to other organism;nucleobase-containing small molecule metabolic process;cellular nitrogen compound catabolic process;protein oligomerization;regulation of immune response;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;regulation of response to stress;macromolecular complex subunit organization;purine-containing compound metabolic process;purine-containing compound catabolic process;protein complex subunit organization;organic cyclic compound metabolic process;protein homooligomerization;protein tetramerization;organic substance metabolic process;cellular response to organic substance;regulation of innate immune response;innate immune response;protein complex assembly;response to type I interferon;single-organism cellular process;type I interferon signaling pathway;cell communication;catabolic process;primary metabolic process;cellular metabolic process;deoxyribose phosphate metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;immune effector process;purine deoxyribonucleoside triphosphate metabolic process; 6;8;3;6;4;5;2;5;4;3;4;4;8;3;4;7;7;4;3;4;2;3;3;3;8;2;4;4;6;6;7;7;3;7;2;4;6;4;6;8;3;5;2;5;4;5;5;6;7;3;7;3;4;5;3;5;1;6;2;3;5;5;4;6;2;5;6;5;5;4;4;4;8;2;4;3;2;4;6;2;4;8;4;4;5;6;4;5;4;4;4;5;6;5;4;7;7;3;5;5;4;5;5;3;7;4;3;3;3;5;5;3;3;8; GO:0031974;GO:0005654;GO:0016020;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0043226;GO:0005886;GO:0031981;GO:0005575;GO:0070013; membrane-enclosed lumen;nucleoplasm;membrane;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;intracellular organelle part;nucleus;cell part;cell;intracellular;cell periphery;organelle;plasma membrane;nuclear lumen;cellular_component;intracellular organelle lumen; 2;5;2;4;3;4;3;2;3;3;3;5;2;2;3;3;2;3;5;1;4; GO:0043169;GO:1901363;GO:0000166;GO:0017076;GO:0097367;GO:0003674;GO:0005488;GO:0003676;GO:0046914;GO:0016787;GO:0003824;GO:0097159;GO:0019001;GO:0016793;GO:0046872;GO:0043168;GO:0008270;GO:0043167;GO:0032560;GO:0032567;GO:0008832;GO:0032554;GO:0042578;GO:0016788;GO:0003723;GO:1901265;GO:0036094;GO:0032552; cation binding;heterocyclic compound binding;nucleotide binding;purine nucleotide binding;carbohydrate derivative binding;molecular_function;binding;nucleic acid binding;transition metal ion binding;hydrolase activity;catalytic activity;organic cyclic compound binding;guanyl nucleotide binding;triphosphoric monoester hydrolase activity;metal ion binding;anion binding;zinc ion binding;ion binding;guanyl deoxyribonucleotide binding;dGTP binding;dGTPase activity;purine deoxyribonucleotide binding;phosphoric ester hydrolase activity;hydrolase activity, acting on ester bonds;RNA binding;nucleoside phosphate binding;small molecule binding;deoxyribonucleotide binding; 4;3;4;5;3;1;2;4;6;3;2;3;6;6;5;4;7;3;5;6;7;5;5;4;5;4;3;4; K22544 IPR013761;IPR001660;IPR003607;IPR006674; Sterile alpha motif/pointed domain;Sterile alpha motif domain;HD/PDEase domain;HD domain; nucleus Hs14770705 1306.0 S [S] Function unknown; Q17RP2 Tigger transposable element-derived protein 6 OS=Homo sapiens OX=9606 GN=TIGD6 PE=2 SV=2 - [TIGD6_HUMAN] 1.165 1.064 0.922 0.94 1.102 0.976 1.094924812 nan 0.852994555 nan 0.866541353 nan 0.885662432 nan GO:0043231;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0044424;GO:0043227;GO:0043226; intracellular membrane-bounded organelle;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle;intracellular part;membrane-bounded organelle;organelle; 4;5;2;2;3;1;3;3;3;2; GO:0097159;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901363; organic cyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;heterocyclic compound binding; 3;1;2;4;5;3; IPR007889;IPR009057;IPR006600;IPR004875;IPR011991; DNA binding HTH domain, Psq-type;Homeobox domain-like;HTH CenpB-type DNA-binding domain;DDE superfamily endonuclease domain;Winged helix-turn-helix DNA-binding domain; cytosol Hs13569924 1085.0 BD [B] Chromatin structure and dynamics;[D] Cell cycle control, cell division, chromosome partitioning; Q9HBU6 Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1 - [EKI1_HUMAN] 1.147 1.198 0.864 0.884 1.139 0.844 0.957429048 0.483409324 0.776119403 0.151074542 0.721202003 0.008399903 0.741000878 0.01496064 GO:0006650;GO:0044249;GO:0044237;GO:0044255;GO:0044699;GO:1901576;GO:0044710;GO:0044711;GO:0071704;GO:0006646;GO:0006644;GO:0006629;GO:0045017;GO:0009987;GO:0019637;GO:0009058;GO:0008150;GO:0046337;GO:0008152;GO:0046486;GO:0090407;GO:0008610;GO:0044238;GO:0008654;GO:0044763;GO:0006796;GO:0006793;GO:0046474;GO:0044281; glycerophospholipid metabolic process;cellular biosynthetic process;cellular metabolic process;cellular lipid metabolic process;single-organism process;organic substance biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;organic substance metabolic process;phosphatidylethanolamine biosynthetic process;phospholipid metabolic process;lipid metabolic process;glycerolipid biosynthetic process;cellular process;organophosphate metabolic process;biosynthetic process;biological_process;phosphatidylethanolamine metabolic process;metabolic process;glycerolipid metabolic process;organophosphate biosynthetic process;lipid biosynthetic process;primary metabolic process;phospholipid biosynthetic process;single-organism cellular process;phosphate-containing compound metabolic process;phosphorus metabolic process;glycerophospholipid biosynthetic process;small molecule metabolic process; 6;4;3;4;2;4;3;4;3;7;5;4;5;2;4;3;1;7;2;5;5;5;3;5;3;5;4;6;4; GO:0031974;GO:0043229;GO:0071944;GO:0043227;GO:0005737;GO:0031981;GO:0070013;GO:0005634;GO:0016020;GO:0044444;GO:0043226;GO:0005654;GO:0044446;GO:0005886;GO:0043231;GO:0005829;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;cell periphery;membrane-bounded organelle;cytoplasm;nuclear lumen;intracellular organelle lumen;nucleus;membrane;cytoplasmic part;organelle;nucleoplasm;intracellular organelle part;plasma membrane;intracellular membrane-bounded organelle;cytosol;organelle lumen;cell part;cell;intracellular;cellular_component;nuclear part;intracellular part;organelle part; 2;3;3;3;4;5;4;5;2;4;2;5;3;3;4;5;3;2;2;3;1;4;3;2; GO:0005488;GO:0017076;GO:0032553;GO:0035639;GO:1901363;GO:0003674;GO:0001883;GO:0043167;GO:0001882;GO:0003824;GO:0016740;GO:0004305;GO:1901265;GO:0032549;GO:0032559;GO:0097367;GO:0005524;GO:0043168;GO:0016301;GO:0000166;GO:0036094;GO:0032555;GO:0016773;GO:0016772;GO:0030554;GO:0097159;GO:0032550; binding;purine nucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;purine nucleoside binding;ion binding;nucleoside binding;catalytic activity;transferase activity;ethanolamine kinase activity;nucleoside phosphate binding;ribonucleoside binding;adenyl ribonucleotide binding;carbohydrate derivative binding;ATP binding;anion binding;kinase activity;nucleotide binding;small molecule binding;purine ribonucleotide binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl nucleotide binding;organic cyclic compound binding;purine ribonucleoside binding; 2;5;4;5;3;1;5;3;4;2;3;6;4;5;6;3;6;4;5;4;3;5;5;4;6;3;6; K00894 map00564;map01100; Glycerophospholipid metabolism;Metabolic pathways; IPR011009; Protein kinase-like domain; plasma membrane Hs10092615 943.0 I [I] Lipid transport and metabolism; Q9UJM3 ERBB receptor feedback inhibitor 1 OS=Homo sapiens OX=9606 GN=ERRFI1 PE=1 SV=1 - [ERRFI_HUMAN] 1.271 1.007 0.833 1.124 0.988 1.023 1.262164846 nan 1.137651822 nan 0.827209533 nan 1.035425101 nan GO:0043408;GO:0009628;GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0003012;GO:0072358;GO:0042035;GO:0006972;GO:0007166;GO:0042036;GO:1901576;GO:0023014;GO:0010648;GO:0044710;GO:0044711;GO:0010605;GO:0070371;GO:0009968;GO:0042534;GO:0048869;GO:0042536;GO:0018212;GO:0070848;GO:0018193;GO:0042533;GO:0032691;GO:0030856;GO:0044093;GO:0044092;GO:0048519;GO:0008544;GO:0032720;GO:0042127;GO:0032652;GO:0030216;GO:0032651;GO:0060255;GO:0031960;GO:0045859;GO:0007175;GO:0071364;GO:0007173;GO:0071363;GO:0043434;GO:0010033;GO:0003008;GO:0042325;GO:0044700;GO:0042326;GO:0042089;GO:0044707;GO:0044249;GO:0019538;GO:0050730;GO:0010243;GO:0050732;GO:0072359;GO:0045682;GO:0007154;GO:0033554;GO:0071407;GO:0007165;GO:0033673;GO:0014741;GO:0014743;GO:0009892;GO:0032640;GO:0009890;GO:0003300;GO:0006950;GO:0007167;GO:0009887;GO:0031952;GO:0031953;GO:0080134;GO:0014070;GO:0006469;GO:1903556;GO:1903555;GO:0007169;GO:1901184;GO:0050673;GO:0050789;GO:0044267;GO:0010646;GO:0043547;GO:0044260;GO:0032611;GO:0044342;GO:0043086;GO:0023051;GO:0065007;GO:0044246;GO:0061097;GO:0060426;GO:0061099;GO:0065009;GO:0071214;GO:0035556;GO:0043085;GO:0051384;GO:0050793;GO:0050790;GO:0009889;GO:0051716;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0051348;GO:0008152;GO:0014897;GO:1902532;GO:1902531;GO:0051336;GO:0044767;GO:0031400;GO:1901699;GO:0010713;GO:0010712;GO:0051338;GO:0070372;GO:0009966;GO:0014896;GO:0010556;GO:0048545;GO:0014898;GO:0010558;GO:0097306;GO:0010563;GO:0051239;GO:0060541;GO:0016310;GO:0030154;GO:0032964;GO:0032965;GO:0032966;GO:0030323;GO:0023052;GO:0038127;GO:0070887;GO:0032963;GO:0003299;GO:0009653;GO:0043087;GO:0046777;GO:0044699;GO:0014745;GO:0009719;GO:0051248;GO:0014888;GO:0071375;GO:0044057;GO:1901698;GO:0051241;GO:0051246;GO:0071474;GO:0048513;GO:0043549;GO:0031399;GO:1903243;GO:1903242;GO:0071383;GO:0071495;GO:0036119;GO:0032501;GO:0061469;GO:0044238;GO:0032612;GO:0071385;GO:0060428;GO:0009987;GO:0071396;GO:0032870;GO:0071548;GO:0006970;GO:0018108;GO:0044259;GO:0070849;GO:0044252;GO:0032269;GO:0032268;GO:0050678;GO:0010612;GO:0009725;GO:0043170;GO:0001816;GO:0001817;GO:0048731;GO:0045616;GO:0070373;GO:0050896;GO:0001818;GO:0032502;GO:0007176;GO:0036120;GO:0030324;GO:0001944;GO:0031327;GO:0031326;GO:0060429;GO:0031324;GO:0031323;GO:0071384;GO:0042059;GO:0042058;GO:0030855;GO:0014887;GO:0032869;GO:0032868;GO:0043502;GO:0007275;GO:0043500;GO:0043409;GO:0009888;GO:1901185;GO:0000165;GO:0033993;GO:0071417;GO:0008283;GO:1901654;GO:0032692;GO:0071704;GO:0071310;GO:0071706;GO:0045604;GO:2000026;GO:0010469;GO:0043588;GO:0043589;GO:0006468;GO:0048286;GO:0045936;GO:0042107;GO:0006464;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0090257;GO:0042221;GO:0035295;GO:1901700;GO:1901701;GO:0071549;GO:0010611;GO:0010616;GO:0051345;GO:0010614;GO:0009913;GO:0071470;GO:2000272;GO:0048856;GO:0045595;GO:0044237;GO:0044236;GO:0032680;GO:0006796;GO:1901655;GO:1901652;GO:1901653;GO:0097305;GO:0006793;GO:0001933;GO:0001932;GO:0023057;GO:0048523; regulation of MAPK cascade;response to abiotic stimulus;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;muscle system process;cardiovascular system development;regulation of cytokine biosynthetic process;hyperosmotic response;cell surface receptor signaling pathway;negative regulation of cytokine biosynthetic process;organic substance biosynthetic process;signal transduction by protein phosphorylation;negative regulation of cell communication;single-organism metabolic process;single-organism biosynthetic process;negative regulation of macromolecule metabolic process;ERK1 and ERK2 cascade;negative regulation of signal transduction;regulation of tumor necrosis factor biosynthetic process;cellular developmental process;negative regulation of tumor necrosis factor biosynthetic process;peptidyl-tyrosine modification;response to growth factor;peptidyl-amino acid modification;tumor necrosis factor biosynthetic process;negative regulation of interleukin-1 beta production;regulation of epithelial cell differentiation;positive regulation of molecular function;negative regulation of molecular function;negative regulation of biological process;epidermis development;negative regulation of tumor necrosis factor production;regulation of cell proliferation;regulation of interleukin-1 production;keratinocyte differentiation;regulation of interleukin-1 beta production;regulation of macromolecule metabolic process;response to corticosteroid;regulation of protein kinase activity;negative regulation of epidermal growth factor-activated receptor activity;cellular response to epidermal growth factor stimulus;epidermal growth factor receptor signaling pathway;cellular response to growth factor stimulus;response to peptide hormone;response to organic substance;system process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;cytokine biosynthetic process;single-multicellular organism process;cellular biosynthetic process;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;response to organonitrogen compound;negative regulation of peptidyl-tyrosine phosphorylation;circulatory system development;regulation of epidermis development;cell communication;cellular response to stress;cellular response to organic cyclic compound;signal transduction;negative regulation of kinase activity;negative regulation of muscle hypertrophy;regulation of muscle hypertrophy;negative regulation of metabolic process;tumor necrosis factor production;negative regulation of biosynthetic process;cardiac muscle hypertrophy;response to stress;enzyme linked receptor protein signaling pathway;organ morphogenesis;regulation of protein autophosphorylation;negative regulation of protein autophosphorylation;regulation of response to stress;response to organic cyclic compound;negative regulation of protein kinase activity;negative regulation of tumor necrosis factor superfamily cytokine production;regulation of tumor necrosis factor superfamily cytokine production;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of ERBB signaling pathway;epithelial cell proliferation;regulation of biological process;cellular protein metabolic process;regulation of cell communication;positive regulation of GTPase activity;cellular macromolecule metabolic process;interleukin-1 beta production;type B pancreatic cell proliferation;negative regulation of catalytic activity;regulation of signaling;biological regulation;regulation of multicellular organismal metabolic process;regulation of protein tyrosine kinase activity;lung vasculature development;negative regulation of protein tyrosine kinase activity;regulation of molecular function;cellular response to abiotic stimulus;intracellular signal transduction;positive regulation of catalytic activity;response to glucocorticoid;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;macromolecule modification;protein modification process;biological_process;negative regulation of transferase activity;metabolic process;striated muscle hypertrophy;negative regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of hydrolase activity;single-organism developmental process;negative regulation of protein modification process;cellular response to nitrogen compound;negative regulation of collagen metabolic process;regulation of collagen metabolic process;regulation of transferase activity;regulation of ERK1 and ERK2 cascade;regulation of signal transduction;muscle hypertrophy;regulation of macromolecule biosynthetic process;response to steroid hormone;cardiac muscle hypertrophy in response to stress;negative regulation of macromolecule biosynthetic process;cellular response to alcohol;negative regulation of phosphorus metabolic process;regulation of multicellular organismal process;respiratory system development;phosphorylation;cell differentiation;collagen biosynthetic process;regulation of collagen biosynthetic process;negative regulation of collagen biosynthetic process;respiratory tube development;signaling;ERBB signaling pathway;cellular response to chemical stimulus;collagen metabolic process;muscle hypertrophy in response to stress;anatomical structure morphogenesis;regulation of GTPase activity;protein autophosphorylation;single-organism process;negative regulation of muscle adaptation;response to endogenous stimulus;negative regulation of protein metabolic process;striated muscle adaptation;cellular response to peptide hormone stimulus;regulation of system process;response to nitrogen compound;negative regulation of multicellular organismal process;regulation of protein metabolic process;cellular hyperosmotic response;animal organ development;regulation of kinase activity;regulation of protein modification process;negative regulation of cardiac muscle hypertrophy in response to stress;regulation of cardiac muscle hypertrophy in response to stress;cellular response to steroid hormone stimulus;cellular response to endogenous stimulus;response to platelet-derived growth factor;multicellular organismal process;regulation of type B pancreatic cell proliferation;primary metabolic process;interleukin-1 production;cellular response to glucocorticoid stimulus;lung epithelium development;cellular process;cellular response to lipid;cellular response to hormone stimulus;response to dexamethasone;response to osmotic stress;peptidyl-tyrosine phosphorylation;multicellular organismal macromolecule metabolic process;response to epidermal growth factor;negative regulation of multicellular organismal metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of epithelial cell proliferation;regulation of cardiac muscle adaptation;response to hormone;macromolecule metabolic process;cytokine production;regulation of cytokine production;system development;regulation of keratinocyte differentiation;negative regulation of ERK1 and ERK2 cascade;response to stimulus;negative regulation of cytokine production;developmental process;regulation of epidermal growth factor-activated receptor activity;cellular response to platelet-derived growth factor stimulus;lung development;vasculature development;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;epithelium development;negative regulation of cellular metabolic process;regulation of cellular metabolic process;cellular response to corticosteroid stimulus;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;epithelial cell differentiation;cardiac muscle adaptation;cellular response to insulin stimulus;response to insulin;regulation of muscle adaptation;multicellular organism development;muscle adaptation;negative regulation of MAPK cascade;tissue development;negative regulation of ERBB signaling pathway;MAPK cascade;response to lipid;cellular response to organonitrogen compound;cell proliferation;response to ketone;negative regulation of interleukin-1 production;organic substance metabolic process;cellular response to organic substance;tumor necrosis factor superfamily cytokine production;regulation of epidermal cell differentiation;regulation of multicellular organismal development;regulation of receptor activity;skin development;skin morphogenesis;protein phosphorylation;lung alveolus development;negative regulation of phosphate metabolic process;cytokine metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of muscle system process;response to chemical;tube development;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular response to dexamethasone stimulus;regulation of cardiac muscle hypertrophy;negative regulation of cardiac muscle adaptation;positive regulation of hydrolase activity;negative regulation of cardiac muscle hypertrophy;epidermal cell differentiation;cellular response to osmotic stress;negative regulation of receptor activity;anatomical structure development;regulation of cell differentiation;cellular metabolic process;multicellular organism metabolic process;regulation of tumor necrosis factor production;phosphate-containing compound metabolic process;cellular response to ketone;response to peptide;cellular response to peptide;response to alcohol;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of signaling;negative regulation of cellular process; 6;3;6;4;3;3;3;4;5;5;5;5;5;4;4;4;3;4;4;6;4;6;4;6;8;5;7;6;6;5;4;4;2;6;6;4;5;6;6;4;6;7;6;5;9;6;5;4;3;7;3;7;5;3;4;4;8;4;8;5;5;4;4;6;4;7;4;6;3;6;4;7;3;6;4;8;8;4;5;8;5;5;7;5;4;2;5;4;7;4;6;5;5;3;2;4;8;5;9;3;4;5;5;7;3;4;4;3;3;5;5;1;6;2;6;5;5;5;3;6;5;5;5;5;7;4;5;5;5;5;5;6;5;3;5;6;5;5;6;6;4;2;8;4;6;4;3;6;8;2;4;3;5;4;6;4;4;3;5;6;4;6;6;6;5;6;4;4;2;6;3;5;8;5;2;6;5;6;4;8;5;4;4;5;5;5;5;4;4;4;4;4;7;7;2;4;2;5;5;4;5;5;5;5;4;4;7;6;6;6;5;7;6;4;4;3;6;4;5;5;5;5;3;5;5;3;5;5;6;4;4;5;5;7;4;6;5;6;5;3;5;3;5;3;4;4;5;7;5;5;6;5;7;5;5;3;4;3;4;6;5;6;5;6;5;4;7;7;3;3; GO:0044444;GO:0016020;GO:0043231;GO:0098562;GO:0044424;GO:0044425;GO:0005829;GO:0043227;GO:0009898;GO:0005737;GO:0098552;GO:0019897;GO:0019898;GO:0005634;GO:0044459;GO:0044464;GO:0043229;GO:0005623;GO:0031234;GO:0071944;GO:0043226;GO:0005622;GO:0005886;GO:0005575; cytoplasmic part;membrane;intracellular membrane-bounded organelle;cytoplasmic side of membrane;intracellular part;membrane part;cytosol;membrane-bounded organelle;cytoplasmic side of plasma membrane;cytoplasm;side of membrane;extrinsic component of plasma membrane;extrinsic component of membrane;nucleus;plasma membrane part;cell part;intracellular organelle;cell;extrinsic component of cytoplasmic side of plasma membrane;cell periphery;organelle;intracellular;plasma membrane;cellular_component; 4;2;4;4;3;2;5;3;4;4;3;4;3;5;3;2;3;2;4;3;2;3;3;1; GO:0098772;GO:0005096;GO:0019901;GO:0030695;GO:0003674;GO:0030234;GO:0019899;GO:0060589;GO:0005515;GO:0005488;GO:0008047;GO:0019900; molecular function regulator;GTPase activator activity;protein kinase binding;GTPase regulator activity;molecular_function;enzyme regulator activity;enzyme binding;nucleoside-triphosphatase regulator activity;protein binding;binding;enzyme activator activity;kinase binding; 2;5;6;5;1;3;4;4;3;2;4;5; IPR021619; Mig-6 domain; cytosol Q709C8 Vacuolar protein sorting-associated protein 13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1 - [VP13C_HUMAN] 1.227 1.059 0.941 1.174 0.842 0.925 1.158640227 nan 1.394299287 nan 0.888574127 nan 1.098574822 nan GO:0042592;GO:0042593;GO:0016482;GO:0051641;GO:0048878;GO:0044699;GO:0051234;GO:0033500;GO:0065007;GO:0065008;GO:0048193;GO:0006810;GO:0006895;GO:0044765;GO:0008150;GO:0007034;GO:0051649;GO:0051179;GO:1902578;GO:0016197;GO:0006892;GO:0006896;GO:0046907;GO:1902582;GO:0016192; homeostatic process;glucose homeostasis;cytosolic transport;cellular localization;chemical homeostasis;single-organism process;establishment of localization;carbohydrate homeostasis;biological regulation;regulation of biological quality;Golgi vesicle transport;transport;Golgi to endosome transport;single-organism transport;biological_process;vacuolar transport;establishment of localization in cell;localization;single-organism localization;endosomal transport;post-Golgi vesicle-mediated transport;Golgi to vacuole transport;intracellular transport;single-organism intracellular transport;vesicle-mediated transport; 4;7;6;3;5;2;3;6;2;3;6;4;7;4;1;6;4;2;3;7;7;7;5;5;5; GO:0019898;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0016020;GO:0044425;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421; extrinsic component of membrane;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;membrane;membrane part;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part; 3;3;2;4;4;2;2;3;4;3;2;2;3;1;2;3;2; K19525 IPR031642;IPR026854;IPR031646;IPR015412;IPR009543;IPR026847;IPR031645; VPS13, repeated coiled region;Vacuolar protein sorting-associated protein 13, N-terminal domain;Vacuolar protein sorting-associated protein 13, second N-terminal domain;Autophagy-related, C-terminal;Vacuolar protein sorting-associated protein 13, SHR-binding domain;Vacuolar protein sorting-associated protein 13;Vacuolar protein sorting-associated protein 13, C-terminal; cytosol Hs20550856 2894.0 U [U] Intracellular trafficking, secretion, and vesicular transport; P41252 Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS PE=1 SV=2 - [SYIC_HUMAN] 0.938 0.989 1.176 1.038 1.055 0.758 0.94843276 0.519225298 0.983886256 0.416630056 1.189079879 0.281383197 0.718483412 0.170066271 GO:0001503;GO:0044281;GO:0044707;GO:1901360;GO:0044710;GO:0048869;GO:0043043;GO:0043436;GO:0046483;GO:1901564;GO:1901566;GO:0019538;GO:0043038;GO:0043039;GO:0006807;GO:0034660;GO:0044267;GO:0044260;GO:0006428;GO:0008150;GO:0008152;GO:0016070;GO:0044271;GO:0043603;GO:0006518;GO:0030154;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0043604;GO:0006082;GO:0043170;GO:0019752;GO:0090304;GO:0001887;GO:0001649;GO:0006399;GO:0006520;GO:0071704;GO:0010467;GO:1901576;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0044238;GO:0044237;GO:0006418;GO:0006412; ossification;small molecule metabolic process;single-multicellular organism process;organic cyclic compound metabolic process;single-organism metabolic process;cellular developmental process;peptide biosynthetic process;oxoacid metabolic process;heterocycle metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;amino acid activation;tRNA aminoacylation;nitrogen compound metabolic process;ncRNA metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;isoleucyl-tRNA aminoacylation;biological_process;metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;cellular amide metabolic process;peptide metabolic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;amide biosynthetic process;organic acid metabolic process;macromolecule metabolic process;carboxylic acid metabolic process;nucleic acid metabolic process;selenium compound metabolic process;osteoblast differentiation;tRNA metabolic process;cellular amino acid metabolic process;organic substance metabolic process;gene expression;organic substance biosynthetic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;primary metabolic process;cellular metabolic process;tRNA aminoacylation for protein translation;translation; 4;4;3;4;3;4;6;5;4;4;5;4;5;6;3;6;5;4;8;1;2;5;5;5;5;5;4;4;5;2;4;2;2;2;4;6;4;4;6;5;4;5;7;4;3;5;4;3;3;5;3;3;3;7;6; GO:0031974;GO:0031982;GO:0031981;GO:0016020;GO:0043230;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0070062;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;vesicle;nuclear lumen;membrane;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;cell part;cell;extracellular exosome;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;5;2;3;4;3;5;4;3;2;2;3;3;3;2;5;3;4;4;5;2;2;4;3;1;4;2; GO:0004812;GO:0000166;GO:0097367;GO:0003674;GO:0005488;GO:0002161;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0016788;GO:0036094;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0004822;GO:0035639;GO:0019899;GO:0043167;GO:0052689;GO:0030554;GO:0051020;GO:0005515;GO:0001882;GO:0001883;GO:0016874;GO:0016875;GO:0016876;GO:0043168; aminoacyl-tRNA ligase activity;nucleotide binding;carbohydrate derivative binding;molecular_function;binding;aminoacyl-tRNA editing activity;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;hydrolase activity, acting on ester bonds;small molecule binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;isoleucine-tRNA ligase activity;purine ribonucleoside triphosphate binding;enzyme binding;ion binding;carboxylic ester hydrolase activity;adenyl nucleotide binding;GTPase binding;protein binding;nucleoside binding;purine nucleoside binding;ligase activity;ligase activity, forming carbon-oxygen bonds;ligase activity, forming aminoacyl-tRNA and related compounds;anion binding; 6;4;3;1;2;6;4;3;5;5;6;3;2;4;3;3;6;5;6;4;7;5;4;3;5;6;5;3;4;5;3;4;5;4; K01870 map00970; Aminoacyl-tRNA biosynthesis; IPR023586;IPR033709;IPR009080;IPR014729;IPR001412;IPR002301;IPR002300;IPR009008;IPR013155; Isoleucine-tRNA ligase, type 2;Isoleucyl tRNA synthetase type 2, anticodon-binding domain;Aminoacyl-tRNA synthetase, class Ia, anticodon-binding;Rossmann-like alpha/beta/alpha sandwich fold;Aminoacyl-tRNA synthetase, class I, conserved site;Isoleucine-tRNA ligase;Aminoacyl-tRNA synthetase, class Ia;Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain;Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding; cytosol Hs4504555 2620.0 J [J] Translation, ribosomal structure and biogenesis; Q8TCP9 Protein FAM200A OS=Homo sapiens OX=9606 GN=FAM200A PE=1 SV=1 - [F200A_HUMAN] 0.747 0.476 2.343 0.632 0.711 0.767 1.569327731 nan 0.888888889 nan 4.922268908 nan 1.078762307 nan GO:0016021;GO:0016020;GO:0005575;GO:0044425;GO:0031224; integral component of membrane;membrane;cellular_component;membrane part;intrinsic component of membrane; 4;2;1;2;3; GO:0097159;GO:0003674;GO:0005488;GO:0003676;GO:1901363; organic cyclic compound binding;molecular_function;binding;nucleic acid binding;heterocyclic compound binding; 3;1;2;4;3; IPR012337; Ribonuclease H-like domain; cytoskeleton A0A0J9YXX1 Immunoglobulin heavy variable 5-10-1 OS=Homo sapiens OX=9606 GN=IGHV5-10-1 PE=3 SV=1 - [HV5X1_HUMAN] 1.238 0.991 0.818 1.119 1.029 0.803 1.249243189 0.069413541 1.087463557 0.101565619 0.82542886 0.152848389 0.780369291 0.196534408 IPR013106;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular O94913 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3 - [PCF11_HUMAN] 0.993 1.037 0.954 0.748 1.069 2.234 0.957569913 nan 0.699719364 nan 0.919961427 nan 2.089803555 nan GO:1901362;GO:1901360;GO:0046483;GO:0000398;GO:0019438;GO:0006378;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0006366;GO:0006369;GO:0018130;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0016071;GO:0006379;GO:0044271;GO:0009059;GO:0006351;GO:0006353;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0008380;GO:0009987;GO:0006725;GO:0090501;GO:0043170;GO:0090304;GO:0090305;GO:0043631;GO:0071704;GO:0010467;GO:0031124;GO:0031123;GO:0000375;GO:0009058;GO:0000377;GO:0044238;GO:0044237;GO:0006396;GO:0006397; organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;heterocycle metabolic process;mRNA splicing, via spliceosome;aromatic compound biosynthetic process;mRNA polyadenylation;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;transcription from RNA polymerase II promoter;termination of RNA polymerase II transcription;heterocycle biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;mRNA metabolic process;mRNA cleavage;cellular nitrogen compound biosynthetic process;macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, termination;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;RNA splicing;cellular process;cellular aromatic compound metabolic process;RNA phosphodiester bond hydrolysis;macromolecule metabolic process;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;RNA polyadenylation;organic substance metabolic process;gene expression;mRNA 3'-end processing;RNA 3'-end processing;RNA splicing, via transesterification reactions;biosynthetic process;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;primary metabolic process;cellular metabolic process;RNA processing;mRNA processing; 5;4;4;8;5;7;3;7;4;4;7;8;5;1;2;5;5;6;7;5;5;6;7;6;4;4;5;4;7;2;4;6;4;5;6;6;3;5;8;7;8;3;9;3;3;6;7; GO:0031974;GO:0031981;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0005849;GO:0044446;GO:0005737;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;mRNA cleavage factor complex;intracellular organelle part;cytoplasm;nucleus;nucleoplasm part;cell part;cell;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;3;4;3;4;3;2;3;3;3;2;5;4;3;4;5;5;2;2;2;1;4; GO:1901363;GO:0000993;GO:0003674;GO:0005488;GO:0003676;GO:0001098;GO:0001099;GO:0097159;GO:0019899;GO:0032403;GO:0044822;GO:0043175;GO:0003723;GO:0005515;GO:0044877;GO:0003729;GO:0070063; heterocyclic compound binding;RNA polymerase II core binding;molecular_function;binding;nucleic acid binding;basal transcription machinery binding;basal RNA polymerase II transcription machinery binding;organic cyclic compound binding;enzyme binding;protein complex binding;poly(A) RNA binding;RNA polymerase core enzyme binding;RNA binding;protein binding;macromolecular complex binding;mRNA binding;RNA polymerase binding; 3;5;1;2;4;4;5;3;4;4;6;6;5;3;3;7;5; K14400 map03015; mRNA surveillance pathway; IPR006569;IPR008942;IPR006903; CID domain;ENTH/VHS;RNA polymerase II-binding domain; nucleus Hs7706224 1429.0 A [A] RNA processing and modification; Q92560 Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2 - [BAP1_HUMAN] 0.848 1.005 1.425 0.81 1.12 0.548 0.843781095 nan 0.723214286 nan 1.417910448 nan 0.489285714 nan GO:0033157;GO:0008104;GO:0032388;GO:0051049;GO:0032386;GO:0071840;GO:0044710;GO:0070727;GO:0070647;GO:0070646;GO:0048518;GO:0048519;GO:1903749;GO:0016570;GO:0042127;GO:0051050;GO:0006605;GO:0045184;GO:1903955;GO:0030163;GO:0072655;GO:0006839;GO:0070585;GO:0019538;GO:0010638;GO:0016569;GO:1903651;GO:0071108;GO:0051222;GO:0051223;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0016049;GO:0044260;GO:0006886;GO:0016043;GO:0065007;GO:1903829;GO:0016579;GO:0016578;GO:0051130;GO:0070201;GO:1903649;GO:0006626;GO:0006810;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0051603;GO:0046907;GO:0006511;GO:0016568;GO:0033043;GO:0051128;GO:1903827;GO:1903533;GO:0007005;GO:1904951;GO:0044699;GO:0032880;GO:0009057;GO:0044248;GO:0006508;GO:0008285;GO:0008283;GO:0072594;GO:0009987;GO:0019941;GO:1903747;GO:0001558;GO:0035521;GO:0035520;GO:0035522;GO:0044257;GO:0032879;GO:0016482;GO:0007049;GO:0033036;GO:0043170;GO:0033365;GO:0060341;GO:0043933;GO:0010821;GO:0010822;GO:0043632;GO:0040007;GO:0006325;GO:0040008;GO:0071704;GO:0071702;GO:0034613;GO:0090316;GO:0006464;GO:0044765;GO:0044763;GO:0051649;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0051276;GO:0051726;GO:0044237;GO:1902589;GO:1903214;GO:0015031;GO:1902582;GO:1902580;GO:0048523;GO:0048522; regulation of intracellular protein transport;protein localization;positive regulation of intracellular transport;regulation of transport;regulation of intracellular transport;cellular component organization or biogenesis;single-organism metabolic process;cellular macromolecule localization;protein modification by small protein conjugation or removal;protein modification by small protein removal;positive regulation of biological process;negative regulation of biological process;positive regulation of establishment of protein localization to mitochondrion;histone modification;regulation of cell proliferation;positive regulation of transport;protein targeting;establishment of protein localization;positive regulation of protein targeting to mitochondrion;protein catabolic process;establishment of protein localization to mitochondrion;mitochondrial transport;protein localization to mitochondrion;protein metabolic process;positive regulation of organelle organization;covalent chromatin modification;positive regulation of cytoplasmic transport;protein K48-linked deubiquitination;positive regulation of protein transport;regulation of protein transport;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cell growth;cellular macromolecule metabolic process;intracellular protein transport;cellular component organization;biological regulation;positive regulation of cellular protein localization;protein deubiquitination;histone deubiquitination;positive regulation of cellular component organization;regulation of establishment of protein localization;regulation of cytoplasmic transport;protein targeting to mitochondrion;transport;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;proteolysis involved in cellular protein catabolic process;intracellular transport;ubiquitin-dependent protein catabolic process;chromatin modification;regulation of organelle organization;regulation of cellular component organization;regulation of cellular protein localization;regulation of protein targeting;mitochondrion organization;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;macromolecule catabolic process;cellular catabolic process;proteolysis;negative regulation of cell proliferation;cell proliferation;establishment of protein localization to organelle;cellular process;modification-dependent protein catabolic process;regulation of establishment of protein localization to mitochondrion;regulation of cell growth;monoubiquitinated histone deubiquitination;monoubiquitinated protein deubiquitination;monoubiquitinated histone H2A deubiquitination;cellular protein catabolic process;regulation of localization;cytosolic transport;cell cycle;macromolecule localization;macromolecule metabolic process;protein localization to organelle;regulation of cellular localization;macromolecular complex subunit organization;regulation of mitochondrion organization;positive regulation of mitochondrion organization;modification-dependent macromolecule catabolic process;growth;chromatin organization;regulation of growth;organic substance metabolic process;organic substance transport;cellular protein localization;positive regulation of intracellular protein transport;cellular protein modification process;single-organism transport;single-organism cellular process;establishment of localization in cell;catabolic process;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;chromosome organization;regulation of cell cycle;cellular metabolic process;single-organism organelle organization;regulation of protein targeting to mitochondrion;protein transport;single-organism intracellular transport;single-organism cellular localization;negative regulation of cellular process;positive regulation of cellular process; 6;4;4;4;5;2;3;4;7;6;2;2;4;4;4;3;6;4;5;5;6;6;7;4;5;7;5;8;4;5;2;5;4;5;3;4;6;3;2;3;7;5;4;5;6;5;4;3;5;5;1;2;3;6;5;8;6;5;4;5;7;5;3;2;4;5;4;5;4;3;5;2;7;6;4;6;8;7;6;3;6;4;3;4;6;4;4;6;6;6;2;5;3;3;5;5;4;6;4;3;4;3;2;3;3;4;3;5;4;3;4;6;5;5;4;3;3; GO:0031974;GO:0031519;GO:0031981;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0035517;GO:0043226;GO:0005622;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;PcG protein complex;nuclear lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;PR-DUB complex;organelle;intracellular;macromolecular complex;cellular_component;intracellular organelle lumen; 2;4;5;3;4;3;4;3;2;3;3;5;3;4;5;2;2;5;2;3;2;1;4; GO:0003674;GO:0005488;GO:0004843;GO:0016787;GO:0003824;GO:0036459;GO:0101005;GO:0008234;GO:0019783;GO:0044877;GO:0008233;GO:0003682;GO:0070011; molecular_function;binding;thiol-dependent ubiquitin-specific protease activity;hydrolase activity;catalytic activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitinyl hydrolase activity;cysteine-type peptidase activity;ubiquitin-like protein-specific protease activity;macromolecular complex binding;peptidase activity;chromatin binding;peptidase activity, acting on L-amino acid peptides; 1;2;6;3;2;5;4;6;7;3;4;4;5; K08588 IPR001578; Peptidase C12, ubiquitin carboxyl-terminal hydrolase; nucleus Hs4757836 1500.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9C099 Leucine-rich repeat and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LRRCC1 PE=1 SV=2 - [LRCC1_HUMAN] 0.611 0.675 2.289 0.718 0.649 0.815 0.905185185 nan 1.106317411 nan 3.391111111 nan 1.25577812 nan GO:0022402;GO:0016043;GO:0051301;GO:0071840;GO:0007067;GO:0044699;GO:0000280;GO:1902589;GO:0000278;GO:0009987;GO:0008150;GO:1903047;GO:0006996;GO:0007049;GO:0048285;GO:0044763; cell cycle process;cellular component organization;cell division;cellular component organization or biogenesis;mitotic nuclear division;single-organism process;nuclear division;single-organism organelle organization;mitotic cell cycle;cellular process;biological_process;mitotic cell cycle process;organelle organization;cell cycle;organelle fission;single-organism cellular process; 4;3;4;2;5;2;6;4;5;2;1;5;4;4;5;3; GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0005575;GO:0031981;GO:0005813;GO:0005634;GO:0005814;GO:0005815;GO:0005654;GO:0044430;GO:0044450;GO:0005856;GO:0015630;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;cellular_component;nuclear lumen;centrosome;nucleus;centriole;microtubule organizing center;nucleoplasm;cytoskeletal part;microtubule organizing center part;cytoskeleton;microtubule cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part; 2;3;3;3;2;4;1;5;5;5;5;5;5;4;5;5;6;4;4;3;2;2;3;3;4;4;4;3;2; K16475 IPR001611;IPR032675; Leucine-rich repeat;Leucine-rich repeat domain, L domain-like; cytosol 334145937 87.8 K [K] Transcription; COG4886 Leucine-rich repeat (LRR) protein P10643 Complement component C7 OS=Homo sapiens OX=9606 GN=C7 PE=1 SV=2 - [CO7_HUMAN] 1.009 1.006 1.019 0.987 1.045 1.127 1.002982107 0.764590043 0.944497608 0.636481813 1.012922465 0.026633775 1.0784689 0.000481175 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:0019724;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0019835;GO:0002684;GO:0002682;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0006957;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0002697;GO:0006956;GO:1903317;GO:0008152;GO:0032101;GO:0009611;GO:0044699;GO:0002443;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0016485;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044238;GO:0002250;GO:0002253;GO:0002252; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;cytolysis;positive regulation of immune system process;regulation of immune system process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;complement activation, alternative pathway;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;regulation of immune effector process;complement activation;regulation of protein maturation;metabolic process;regulation of response to external stimulus;response to wounding;single-organism process;leukocyte mediated immunity;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;protein processing;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;primary metabolic process;adaptive immune response;activation of immune response;immune effector process; 4;3;3;3;5;5;3;5;2;2;6;4;4;6;6;3;4;2;5;5;2;3;3;3;4;3;7;1;5;5;3;6;5;4;7;5;2;4;4;6;2;4;4;2;4;5;5;5;2;6;4;5;4;4;4;3;3;5;5;4;5;3;4;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0031224;GO:0031226;GO:0046930;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0005575;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0098797;GO:0098796;GO:0005576;GO:0005579; vesicle;integral component of membrane;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;intrinsic component of membrane;intrinsic component of plasma membrane;pore complex;plasma membrane part;cell part;cell;cell periphery;cellular_component;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;plasma membrane protein complex;membrane protein complex;extracellular region;membrane attack complex; 4;4;2;3;3;2;2;3;3;4;4;3;2;2;3;1;4;2;4;3;3;2;4;3;2;5; K03996 map04610;map05020;map05322; Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus; IPR023415;IPR002172;IPR020864;IPR003884;IPR000436;IPR020863;IPR001862;IPR000884; Low-density lipoprotein (LDL) receptor class A, conserved site;Low-density lipoprotein (LDL) receptor class A repeat;Membrane attack complex component/perforin (MACPF) domain;Factor I / membrane attack complex;Sushi/SCR/CCP domain;Membrane attack complex component/perforin domain, conserved site;Membrane attack complex component/perforin/complement C9;Thrombospondin type-1 (TSP1) repeat; extracellular P19827 Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo sapiens OX=9606 GN=ITIH1 PE=1 SV=3 - [ITIH1_HUMAN] 1.051 1.012 0.955 1.07 1.027 1.03 1.038537549 0.001714738 1.041869523 1.39E-09 0.943675889 0.272730857 1.00292113 2.35E-07 GO:0030203;GO:1903510;GO:0006807;GO:0071704;GO:0030212;GO:0008150;GO:0008152;GO:1901564;GO:1901135;GO:0043170;GO:0006022; glycosaminoglycan metabolic process;mucopolysaccharide metabolic process;nitrogen compound metabolic process;organic substance metabolic process;hyaluronan metabolic process;biological_process;metabolic process;organonitrogen compound metabolic process;carbohydrate derivative metabolic process;macromolecule metabolic process;aminoglycan metabolic process; 6;7;3;3;8;1;2;4;4;4;5; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0072562;GO:0043230;GO:1903561;GO:0031982;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;blood microparticle;extracellular organelle;extracellular vesicle;vesicle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;3;3;4;1;2;2; GO:0004866;GO:0030414;GO:0003674;GO:0005488;GO:0004857;GO:0098772;GO:0043169;GO:0043167;GO:0005509;GO:0046872;GO:0061135;GO:0030234;GO:0061134;GO:0004867; endopeptidase inhibitor activity;peptidase inhibitor activity;molecular_function;binding;enzyme inhibitor activity;molecular function regulator;cation binding;ion binding;calcium ion binding;metal ion binding;endopeptidase regulator activity;enzyme regulator activity;peptidase regulator activity;serine-type endopeptidase inhibitor activity; 6;5;1;2;4;2;4;3;6;5;5;3;4;7; K19014 IPR013694;IPR002035;IPR010600; VIT domain;von Willebrand factor, type A;Inter-alpha-trypsin inhibitor heavy chain, C-terminal; endoplasmic reticulum 283778201 157.0 R [R] General function prediction only; COG2304 Secreted protein containing bacterial Ig-like domain and vWFA domain P01833 Polymeric immunoglobulin receptor OS=Homo sapiens OX=9606 GN=PIGR PE=1 SV=4 - [PIGR_HUMAN] 1.009 0.95 1.11 1.142 0.913 1.172 1.062105263 0.60993179 1.250821468 0.020293589 1.168421053 0.079227793 1.283680175 0.212152626 GO:0008104;GO:0009593;GO:0060249;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0002386;GO:0071840;GO:0051716;GO:0070727;GO:0001580;GO:0002682;GO:0033036;GO:0007606;GO:0007600;GO:0007173;GO:0072657;GO:0051668;GO:0003008;GO:0044700;GO:0044707;GO:0048871;GO:0002385;GO:0002376;GO:0050789;GO:0002764;GO:0002768;GO:0045056;GO:0016043;GO:0065007;GO:0044699;GO:0065008;GO:0006810;GO:0050794;GO:0008150;GO:0006955;GO:0051234;GO:0051606;GO:0038093;GO:0050896;GO:0050913;GO:0044802;GO:0023052;GO:0038127;GO:0007154;GO:0002415;GO:0002414;GO:0032501;GO:0050877;GO:0009987;GO:0001894;GO:0001895;GO:0050776;GO:0042592;GO:0050906;GO:0050907;GO:0050909;GO:0034613;GO:0044765;GO:0050912;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0051641;GO:0002251;GO:0043113;GO:1902580;GO:0016192; protein localization;detection of chemical stimulus;anatomical structure homeostasis;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;immune response in mucosal-associated lymphoid tissue;cellular component organization or biogenesis;cellular response to stimulus;cellular macromolecule localization;detection of chemical stimulus involved in sensory perception of bitter taste;regulation of immune system process;macromolecule localization;sensory perception of chemical stimulus;sensory perception;epidermal growth factor receptor signaling pathway;protein localization to membrane;localization within membrane;system process;single organism signaling;single-multicellular organism process;multicellular organismal homeostasis;mucosal immune response;immune system process;regulation of biological process;immune response-regulating signaling pathway;immune response-regulating cell surface receptor signaling pathway;transcytosis;cellular component organization;biological regulation;single-organism process;regulation of biological quality;transport;regulation of cellular process;biological_process;immune response;establishment of localization;detection of stimulus;Fc receptor signaling pathway;response to stimulus;sensory perception of bitter taste;single-organism membrane organization;signaling;ERBB signaling pathway;cell communication;immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;immunoglobulin transcytosis in epithelial cells;multicellular organismal process;neurological system process;cellular process;tissue homeostasis;retina homeostasis;regulation of immune response;homeostatic process;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception;sensory perception of taste;cellular protein localization;single-organism transport;detection of chemical stimulus involved in sensory perception of taste;single-organism cellular process;response to chemical;localization;single-organism localization;cellular localization;organ or tissue specific immune response;receptor clustering;single-organism cellular localization;vesicle-mediated transport; 4;4;5;3;4;4;5;6;7;6;2;3;4;7;3;3;6;5;9;5;4;3;3;3;4;5;2;2;5;6;5;3;2;2;3;4;3;1;3;3;3;7;2;8;4;2;8;4;7;6;2;4;2;5;6;4;4;4;5;7;5;4;6;3;3;2;3;3;4;5;4;5; GO:0031982;GO:0005615;GO:0016021;GO:0016020;GO:0043235;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0031226;GO:0031224;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005576; vesicle;extracellular space;integral component of membrane;membrane;receptor complex;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;intrinsic component of plasma membrane;intrinsic component of membrane;plasma membrane part;cell part;cell;cell periphery;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 4;3;4;2;4;3;3;2;2;3;4;3;3;2;2;3;4;2;4;3;3;2;1;2; GO:0060089;GO:0099600;GO:0003674;GO:0019763;GO:0001792;GO:0004872;GO:0038023;GO:0004871;GO:0004888; molecular transducer activity;transmembrane receptor activity;molecular_function;immunoglobulin receptor activity;polymeric immunoglobulin receptor activity;receptor activity;signaling receptor activity;signal transducer activity;transmembrane signaling receptor activity; 2;4;1;5;6;3;3;2;4; K13073 map04672; Intestinal immune network for IgA production; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; plasma membrane P01834 Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2 - [IGKC_HUMAN] 1.094 1.086 0.907 0.95 1.164 0.753 1.007366483 0.531786334 0.816151203 1.80E-93 0.835174954 4.56E-83 0.646907216 5.56E-14 GO:0006909;GO:0060249;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0051716;GO:0043207;GO:0048518;GO:0002682;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0048871;GO:0044707;GO:0019538;GO:0002376;GO:0045321;GO:0042742;GO:0050789;GO:0002764;GO:0002431;GO:0002768;GO:0002433;GO:0002684;GO:0065007;GO:0065008;GO:0006810;GO:0044710;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0051234;GO:0038096;GO:0038094;GO:0002757;GO:0006897;GO:0038093;GO:0050896;GO:0006898;GO:0001775;GO:0002694;GO:0002696;GO:0006956;GO:0009617;GO:0023052;GO:0044699;GO:0016043;GO:0006959;GO:0008037;GO:0032501;GO:0009987;GO:0050871;GO:0038095;GO:0098542;GO:0001894;GO:0001895;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0043170;GO:0010324;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0042592;GO:0072376;GO:0002443;GO:0071704;GO:0009605;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522;GO:0016192; phagocytosis;anatomical structure homeostasis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;cellular response to stimulus;response to external biotic stimulus;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;multicellular organismal homeostasis;single-multicellular organism process;protein metabolic process;immune system process;leukocyte activation;defense response to bacterium;regulation of biological process;immune response-regulating signaling pathway;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;positive regulation of immune system process;biological regulation;regulation of biological quality;transport;single-organism metabolic process;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;complement activation, classical pathway;establishment of localization;Fc-gamma receptor signaling pathway involved in phagocytosis;Fc-gamma receptor signaling pathway;immune response-activating signal transduction;endocytosis;Fc receptor signaling pathway;response to stimulus;receptor-mediated endocytosis;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;response to bacterium;signaling;single-organism process;cellular component organization;humoral immune response;cell recognition;multicellular organismal process;cellular process;positive regulation of B cell activation;Fc-epsilon receptor signaling pathway;defense response to other organism;tissue homeostasis;retina homeostasis;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;macromolecule metabolic process;membrane invagination;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;homeostatic process;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;response to external stimulus;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process;vesicle-mediated transport; 5;5;3;3;4;4;5;5;2;3;4;2;3;6;4;3;3;2;3;5;4;3;4;2;3;5;2;5;6;6;4;3;2;3;4;3;3;4;3;7;1;2;3;5;3;5;8;4;6;7;2;7;4;4;4;4;4;2;2;3;4;4;2;2;6;8;4;5;6;4;5;5;4;4;5;4;6;4;5;4;3;4;3;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;5;3;5; GO:0031982;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0043227;GO:0072562;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576; vesicle;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;membrane-bounded organelle;blood microparticle;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell;cell periphery;side of membrane;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region; 4;2;3;3;2;2;4;3;3;3;4;3;3;2;2;3;3;3;2;3;3;4;2;1;2; GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102;GO:0005488; molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding;binding; 1;5;3;3;4;2; IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular P19823 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2 - [ITIH2_HUMAN] 0.999 0.999 1.061 0.996 0.999 1.023 1 0.160405315 0.996996997 0.097009405 1.062062062 1.60E-21 1.024024024 3.60E-10 GO:0030203;GO:0019222;GO:0031324;GO:0031323;GO:1903510;GO:0050789;GO:0006807;GO:0009892;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0030212;GO:0009987;GO:0052547;GO:0052548;GO:0050794;GO:0008150;GO:0008152;GO:0010951;GO:0051346;GO:0006508;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:1901564;GO:0050790;GO:0060255;GO:1901135;GO:0044237;GO:0043170;GO:0019538;GO:0006022;GO:0030162;GO:0045861;GO:0048523; glycosaminoglycan metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mucopolysaccharide metabolic process;regulation of biological process;nitrogen compound metabolic process;negative regulation of metabolic process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;hyaluronan metabolic process;cellular process;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular process;biological_process;metabolic process;negative regulation of endopeptidase activity;negative regulation of hydrolase activity;proteolysis;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;organonitrogen compound metabolic process;regulation of catalytic activity;regulation of macromolecule metabolic process;carbohydrate derivative metabolic process;cellular metabolic process;macromolecule metabolic process;protein metabolic process;aminoglycan metabolic process;regulation of proteolysis;negative regulation of proteolysis;negative regulation of cellular process; 6;3;4;4;7;2;3;3;4;5;5;4;4;5;5;3;7;2;4;2;3;8;2;6;7;3;1;2;8;6;5;5;3;5;5;4;4;4;4;3;4;4;5;6;6;3; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0072562;GO:0043230;GO:1903561;GO:0031982;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;blood microparticle;extracellular organelle;extracellular vesicle;vesicle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;3;3;4;1;2;2; GO:0004866;GO:0030414;GO:0003674;GO:0004857;GO:0098772;GO:0061135;GO:0030234;GO:0061134;GO:0004867; endopeptidase inhibitor activity;peptidase inhibitor activity;molecular_function;enzyme inhibitor activity;molecular function regulator;endopeptidase regulator activity;enzyme regulator activity;peptidase regulator activity;serine-type endopeptidase inhibitor activity; 6;5;1;4;2;5;3;4;7; K19015 IPR013694;IPR002035;IPR010600; VIT domain;von Willebrand factor, type A;Inter-alpha-trypsin inhibitor heavy chain, C-terminal; extracellular 383764369 173.0 R [R] General function prediction only; COG2304 Secreted protein containing bacterial Ig-like domain and vWFA domain Q7RTY7 Ovochymase-1 OS=Homo sapiens OX=9606 GN=OVCH1 PE=2 SV=2 - [OVCH1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0005575;GO:0005576; cellular_component;extracellular region; 1;2; GO:0043169;GO:0004175;GO:0004252;GO:0016787;GO:0017171;GO:0043167;GO:0003824;GO:0003674;GO:0005488;GO:0070011;GO:0008233;GO:0046872;GO:0008236; cation binding;endopeptidase activity;serine-type endopeptidase activity;hydrolase activity;serine hydrolase activity;ion binding;catalytic activity;molecular_function;binding;peptidase activity, acting on L-amino acid peptides;peptidase activity;metal ion binding;serine-type peptidase activity; 4;6;6;3;4;3;2;1;2;5;4;5;5; K01362 IPR001254;IPR000859;IPR009003;IPR018114;IPR033116;IPR001314; Serine proteases, trypsin domain;CUB domain;Peptidase S1, PA clan;Serine proteases, trypsin family, histidine active site;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular Hs18579743 1962.0 E [E] Amino acid transport and metabolism; P04003 C4b-binding protein alpha chain OS=Homo sapiens OX=9606 GN=C4BPA PE=1 SV=2 - [C4BPA_HUMAN] 1.05 0.952 1.011 1.041 0.993 1.014 1.102941176 1.46E-07 1.048338369 1.07E-05 1.06197479 1.93E-06 1.021148036 7.02E-06 GO:0006909;GO:0080090;GO:0019222;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0002707;GO:0002706;GO:0002704;GO:0002703;GO:0016043;GO:0002455;GO:0071840;GO:0044710;GO:0010605;GO:0010604;GO:0050727;GO:0048518;GO:0065007;GO:0002683;GO:0019724;GO:0060255;GO:0002822;GO:0002823;GO:2000257;GO:0032268;GO:0030162;GO:0030163;GO:0002673;GO:0051128;GO:0016192;GO:0009605;GO:0019538;GO:0002820;GO:0002376;GO:0009896;GO:0009894;GO:0030449;GO:0009893;GO:0002923;GO:0010629;GO:0002920;GO:0002924;GO:0050789;GO:0044267;GO:1901575;GO:0044260;GO:0002684;GO:0002682;GO:0031347;GO:0045916;GO:0006810;GO:0051248;GO:0050794;GO:0006952;GO:0002889;GO:0006950;GO:0016064;GO:0006956;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0008228;GO:0045732;GO:0002697;GO:1903318;GO:0008150;GO:1903317;GO:0002698;GO:0008152;GO:0032101;GO:0002819;GO:0009611;GO:0042176;GO:0009892;GO:0044699;GO:0002890;GO:0050764;GO:0051234;GO:0030100;GO:0051246;GO:0051247;GO:0051179;GO:0006508;GO:1903034;GO:0009987;GO:0060627;GO:0002712;GO:0002921;GO:0048519;GO:0016485;GO:0032879;GO:0050777;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:1903027;GO:0045861;GO:0080134;GO:2000258;GO:0031324;GO:0031323;GO:0010955;GO:0032269;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045959;GO:0045087;GO:0002449;GO:0044765;GO:0002713;GO:0030450;GO:0002443;GO:0009056;GO:0009057;GO:1902578;GO:0044238;GO:0044237;GO:0002250;GO:0002253;GO:0002252;GO:0048523; phagocytosis;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;negative regulation of lymphocyte mediated immunity;regulation of lymphocyte mediated immunity;negative regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;cellular component organization;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;negative regulation of immune system process;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of protein activation cascade;regulation of cellular protein metabolic process;regulation of proteolysis;protein catabolic process;regulation of acute inflammatory response;regulation of cellular component organization;vesicle-mediated transport;response to external stimulus;protein metabolic process;negative regulation of adaptive immune response;immune system process;positive regulation of catabolic process;regulation of catabolic process;regulation of complement activation;positive regulation of metabolic process;regulation of humoral immune response mediated by circulating immunoglobulin;negative regulation of gene expression;regulation of humoral immune response;negative regulation of humoral immune response mediated by circulating immunoglobulin;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;positive regulation of immune system process;regulation of immune system process;regulation of defense response;negative regulation of complement activation;transport;negative regulation of protein metabolic process;regulation of cellular process;defense response;regulation of immunoglobulin mediated immune response;response to stress;immunoglobulin mediated immune response;complement activation;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;endocytosis;protein maturation;response to stimulus;opsonization;positive regulation of protein catabolic process;regulation of immune effector process;negative regulation of protein maturation;biological_process;regulation of protein maturation;negative regulation of immune effector process;metabolic process;regulation of response to external stimulus;regulation of adaptive immune response;response to wounding;regulation of protein catabolic process;negative regulation of metabolic process;single-organism process;negative regulation of immunoglobulin mediated immune response;regulation of phagocytosis;establishment of localization;regulation of endocytosis;regulation of protein metabolic process;positive regulation of protein metabolic process;localization;proteolysis;regulation of response to wounding;cellular process;regulation of vesicle-mediated transport;regulation of B cell mediated immunity;negative regulation of humoral immune response;negative regulation of biological process;protein processing;regulation of localization;negative regulation of immune response;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of opsonization;negative regulation of proteolysis;regulation of response to stress;negative regulation of protein activation cascade;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of protein processing;negative regulation of cellular protein metabolic process;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;negative regulation of complement activation, classical pathway;innate immune response;lymphocyte mediated immunity;single-organism transport;negative regulation of B cell mediated immunity;regulation of complement activation, classical pathway;leukocyte mediated immunity;catabolic process;macromolecule catabolic process;single-organism localization;primary metabolic process;cellular metabolic process;adaptive immune response;activation of immune response;immune effector process;negative regulation of cellular process; 5;4;3;4;3;3;3;6;6;5;5;3;5;2;3;4;4;5;2;2;3;6;4;6;6;4;5;6;5;6;4;5;3;4;5;2;4;4;5;3;6;5;5;6;2;5;4;4;3;3;5;5;4;5;3;4;8;3;7;4;5;3;6;5;4;7;6;5;2;4;5;4;6;1;6;4;2;4;5;4;5;3;2;8;6;3;5;5;5;2;5;5;2;4;7;5;2;6;3;4;4;5;4;4;5;6;4;4;4;4;7;5;3;3;5;5;6;4;5;4;7;6;4;3;5;3;3;3;4;3;3;3; GO:0016020;GO:0044216;GO:0044217;GO:0044421;GO:0072562;GO:0044215;GO:0044464;GO:0005623;GO:0071944;GO:0005615;GO:0005886;GO:0005575;GO:0005576; membrane;other organism cell;other organism part;extracellular region part;blood microparticle;other organism;cell part;cell;cell periphery;extracellular space;plasma membrane;cellular_component;extracellular region; 2;3;2;2;3;2;2;2;3;3;3;1;2; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0044822;GO:0003723; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;poly(A) RNA binding;RNA binding; 3;1;2;4;3;6;5; K04002 map04610;map05133; Complement and coagulation cascades;Pertussis; IPR000436; Sushi/SCR/CCP domain; plasma membrane O95025 Semaphorin-3D OS=Homo sapiens OX=9606 GN=SEMA3D PE=2 SV=2 - [SEM3D_HUMAN] 0.808 1.003 1.469 0.877 0.989 0.795 0.80558325 nan 0.886754297 nan 1.464606181 nan 0.803842265 nan GO:0048675;GO:0048589;GO:0048588;GO:0040017;GO:0048585;GO:0048468;GO:0001755;GO:0050920;GO:0007165;GO:0050922;GO:0061387;GO:0031345;GO:0031344;GO:0071840;GO:0014032;GO:0014033;GO:0051716;GO:0014031;GO:0048864;GO:0042330;GO:0048869;GO:0045665;GO:0045664;GO:0048513;GO:0010721;GO:0048518;GO:0048519;GO:0060485;GO:0048699;GO:1990138;GO:0048583;GO:0008361;GO:0010977;GO:0010975;GO:0030517;GO:0030516;GO:0097485;GO:0044700;GO:0016477;GO:0009605;GO:0044707;GO:0048870;GO:0071526;GO:0032535;GO:0022604;GO:0007166;GO:0022603;GO:0006928;GO:0051674;GO:0031175;GO:0050789;GO:0000904;GO:0016049;GO:0000902;GO:0016043;GO:0090066;GO:0065007;GO:0048640;GO:0065008;GO:0061564;GO:0050793;GO:0009888;GO:0050794;GO:0048863;GO:0008150;GO:0051239;GO:0050896;GO:0051961;GO:0051960;GO:2000145;GO:2000147;GO:0048638;GO:0032102;GO:0030308;GO:0032101;GO:0030154;GO:0051129;GO:0051128;GO:0023052;GO:0060284;GO:0042221;GO:0007411;GO:0001667;GO:0009653;GO:0044699;GO:0050767;GO:0051241;GO:0050768;GO:1902284;GO:0010769;GO:0060560;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0001558;GO:0007409;GO:0032879;GO:0048858;GO:0051093;GO:0050771;GO:0050770;GO:0010771;GO:0048731;GO:0045926;GO:0048762;GO:0030030;GO:0040013;GO:1902668;GO:1902667;GO:0006935;GO:0048846;GO:0040008;GO:0048843;GO:0007275;GO:0048812;GO:0048666;GO:0048667;GO:0030335;GO:0030334;GO:0048841;GO:0030182;GO:0044767;GO:0044763;GO:0050919;GO:0007154;GO:0022008;GO:0051179;GO:0040007;GO:0040011;GO:0051272;GO:0051271;GO:0040012;GO:0032990;GO:0007399;GO:0048856;GO:0051270;GO:2000026;GO:0032989;GO:0048523;GO:0048522; axon extension;developmental growth;developmental cell growth;positive regulation of locomotion;negative regulation of response to stimulus;cell development;neural crest cell migration;regulation of chemotaxis;signal transduction;negative regulation of chemotaxis;regulation of extent of cell growth;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;neural crest cell development;neural crest cell differentiation;cellular response to stimulus;mesenchymal cell development;stem cell development;taxis;cellular developmental process;negative regulation of neuron differentiation;regulation of neuron differentiation;animal organ development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;mesenchyme development;generation of neurons;neuron projection extension;regulation of response to stimulus;regulation of cell size;negative regulation of neuron projection development;regulation of neuron projection development;negative regulation of axon extension;regulation of axon extension;neuron projection guidance;single organism signaling;cell migration;response to external stimulus;single-multicellular organism process;cell motility;semaphorin-plexin signaling pathway;regulation of cellular component size;regulation of cell morphogenesis;cell surface receptor signaling pathway;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;neuron projection development;regulation of biological process;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;cellular component organization;regulation of anatomical structure size;biological regulation;negative regulation of developmental growth;regulation of biological quality;axon development;regulation of developmental process;tissue development;regulation of cellular process;stem cell differentiation;biological_process;regulation of multicellular organismal process;response to stimulus;negative regulation of nervous system development;regulation of nervous system development;regulation of cell motility;positive regulation of cell motility;regulation of developmental growth;negative regulation of response to external stimulus;negative regulation of cell growth;regulation of response to external stimulus;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;signaling;regulation of cell development;response to chemical;axon guidance;ameboidal-type cell migration;anatomical structure morphogenesis;single-organism process;regulation of neurogenesis;negative regulation of multicellular organismal process;negative regulation of neurogenesis;neuron projection extension involved in neuron projection guidance;regulation of cell morphogenesis involved in differentiation;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cell growth;axonogenesis;regulation of localization;cell projection morphogenesis;negative regulation of developmental process;negative regulation of axonogenesis;regulation of axonogenesis;negative regulation of cell morphogenesis involved in differentiation;system development;negative regulation of growth;mesenchymal cell differentiation;cell projection organization;negative regulation of locomotion;negative regulation of axon guidance;regulation of axon guidance;chemotaxis;axon extension involved in axon guidance;regulation of growth;negative regulation of axon extension involved in axon guidance;multicellular organism development;neuron projection morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;positive regulation of cell migration;regulation of cell migration;regulation of axon extension involved in axon guidance;neuron differentiation;single-organism developmental process;single-organism cellular process;negative chemotaxis;cell communication;neurogenesis;localization;growth;locomotion;positive regulation of cellular component movement;negative regulation of cellular component movement;regulation of locomotion;cell part morphogenesis;nervous system development;anatomical structure development;regulation of cellular component movement;regulation of multicellular organismal development;cellular component morphogenesis;negative regulation of cellular process;positive regulation of cellular process; 6;3;4;3;3;4;6;4;4;4;5;5;5;2;7;7;3;6;5;3;4;6;7;4;5;2;2;5;7;5;3;5;6;6;5;5;5;3;4;3;3;3;6;4;5;5;4;4;3;5;2;5;3;5;3;4;2;4;3;6;3;4;3;6;1;3;2;4;5;4;4;4;4;4;4;5;4;4;2;5;3;6;5;3;2;6;3;5;6;6;4;2;2;2;4;4;4;7;3;5;3;6;7;5;4;3;6;4;3;5;5;4;7;3;6;4;6;5;6;5;5;6;6;3;3;5;4;6;2;2;2;4;4;3;5;5;3;4;4;4;3;3; GO:0044421;GO:0005615;GO:0005575;GO:0005576; extracellular region part;extracellular space;cellular_component;extracellular region; 2;3;1;2; GO:0045499;GO:0003674;GO:0005488;GO:0038191;GO:0005515;GO:0005102;GO:0030215; chemorepellent activity;molecular_function;binding;neuropilin binding;protein binding;receptor binding;semaphorin receptor binding; 2;1;2;5;3;4;5; K06840 map04360; Axon guidance; IPR003599;IPR007110;IPR013783;IPR027231;IPR015943;IPR016201;IPR001627; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Semaphorin;WD40/YVTN repeat-like-containing domain;PSI domain;Sema domain; endoplasmic reticulum, mitochondria Hs22049564 874.0 T [T] Signal transduction mechanisms; O75592 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4 - [MYCB2_HUMAN] 0.635 0.443 2.506 0.633 0.587 1.012 1.433408578 0.700545909 1.078364566 0.687762197 5.656884876 0.237965915 1.724020443 0.731747607 GO:0080090;GO:0019222;GO:0031326;GO:0043412;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:0016567;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0006464;GO:0070647;GO:0044260;GO:0032446;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0036211;GO:0019538;GO:0044267;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;macromolecule modification;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;protein ubiquitination;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular protein modification process;protein modification by small protein conjugation or removal;cellular macromolecule metabolic process;protein modification by small protein conjugation;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;protein modification process;protein metabolic process;cellular protein metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;5;4;5;4;4;3;5;9;5;2;7;6;4;6;7;4;8;6;3;5;2;4;5;4;5;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0016020;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;membrane;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;2;4;2;3;1;3; GO:0008270;GO:0043169;GO:0003674;GO:0046872;GO:0003824;GO:0016874;GO:0043167;GO:0046914;GO:0005488; zinc ion binding;cation binding;molecular_function;metal ion binding;catalytic activity;ligase activity;ion binding;transition metal ion binding;binding; 7;4;1;5;2;3;3;6;2; K10693 IPR013783;IPR003646;IPR009091;IPR017868;IPR013083;IPR008979;IPR014756;IPR012983;IPR004939;IPR001841;IPR000408; Immunoglobulin-like fold;SH3-like domain, bacterial-type;Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;Filamin/ABP280 repeat-like;Zinc finger, RING/FYVE/PHD-type;Galactose-binding domain-like;Immunoglobulin E-set;PHR;APC10/DOC domain;Zinc finger, RING-type;Regulator of chromosome condensation, RCC1; nucleus Hs7662380 9626.0 T [T] Signal transduction mechanisms; Q14997 Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2 - [PSME4_HUMAN] nan nan nan nan nan nan nan 0.385743459 nan 0.006316116 nan 0.305069273 nan 0.332980659 GO:0044281;GO:0051716;GO:0000003;GO:0072422;GO:0000165;GO:0033238;GO:0006281;GO:0048468;GO:0045859;GO:0007281;GO:0007283;GO:0007286;GO:0007289;GO:0097485;GO:0046483;GO:0042325;GO:0042327;GO:0006576;GO:0019538;GO:0009896;GO:0009894;GO:0009893;GO:0090263;GO:0006595;GO:0030177;GO:0031175;GO:0035556;GO:0071900;GO:0072331;GO:0050789;GO:0051340;GO:0051347;GO:0000902;GO:0010646;GO:0002684;GO:0002682;GO:1901360;GO:0019882;GO:0019884;GO:0009308;GO:0043410;GO:0043412;GO:0071345;GO:0035093;GO:0035092;GO:0048812;GO:0048869;GO:0033209;GO:0007275;GO:0042176;GO:1901991;GO:1901990;GO:0044819;GO:0043488;GO:0043487;GO:0043486;GO:0002220;GO:0002223;GO:0008286;GO:0006974;GO:0006977;GO:0007409;GO:0044257;GO:0006338;GO:0030030;GO:0042590;GO:0022402;GO:2000060;GO:0008219;GO:0043632;GO:0007276;GO:0002218;GO:0006521;GO:0006520;GO:2000058;GO:0043067;GO:0043066;GO:0060548;GO:0043069;GO:0009605;GO:0090090;GO:0006468;GO:0045089;GO:0045088;GO:0045087;GO:0006464;GO:0044767;GO:0044764;GO:0044763;GO:1901700;GO:1901701;GO:0048858;GO:0048856;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0000082;GO:0032147;GO:0031349;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0031347;GO:0044710;GO:0045786;GO:0045787;GO:0070848;GO:0044093;GO:0006935;GO:0072413;GO:0010033;GO:0051704;GO:0044248;GO:0002429;GO:0016567;GO:0044783;GO:0016568;GO:0006807;GO:0048002;GO:0000278;GO:0044267;GO:0044265;GO:0002764;GO:0044260;GO:0002768;GO:0044344;GO:0007049;GO:0050790;GO:0050794;GO:0060070;GO:0000904;GO:0050896;GO:0010498;GO:0010499;GO:0051338;GO:0006511;GO:0072395;GO:0051246;GO:0019953;GO:0010565;GO:0043405;GO:0070887;GO:0000209;GO:0044699;GO:0043408;GO:0071375;GO:0010562;GO:0010564;GO:0051247;GO:0031398;GO:0031399;GO:0031396;GO:0040011;GO:0048609;GO:0048232;GO:0051276;GO:0072431;GO:0048731;GO:0043933;GO:0044772;GO:0006325;GO:0006323;GO:0030178;GO:0071158;GO:0042787;GO:1904666;GO:1904668;GO:0071156;GO:1903364;GO:0045930;GO:0030182;GO:0022414;GO:0022412;GO:0042221;GO:0022008;GO:0007264;GO:0006996;GO:0044238;GO:0044237;GO:0006259;GO:0044403;GO:0019220;GO:0019221;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0030111;GO:0071840;GO:0009968;GO:0009966;GO:0009967;GO:0032446;GO:0048515;GO:0048518;GO:0048519;GO:0038179;GO:0003006;GO:0007173;GO:0043436;GO:0043434;GO:0044700;GO:0044703;GO:0044702;GO:1901564;GO:0044707;GO:0010243;GO:0016055;GO:0002376;GO:0033554;GO:0060828;GO:0071103;GO:0033674;GO:0006928;GO:0042981;GO:0072401;GO:0090068;GO:0031570;GO:0031571;GO:0043549;GO:0061564;GO:0034097;GO:0006952;GO:0012501;GO:0006950;GO:0006955;GO:0048011;GO:1902533;GO:1902531;GO:0007050;GO:0002757;GO:0080134;GO:0031401;GO:0002758;GO:0030154;GO:0048010;GO:0008543;GO:0009719;GO:0006139;GO:0043161;GO:1903320;GO:1903322;GO:0032270;GO:0006508;GO:0032502;GO:0032501;GO:0032504;GO:0051603;GO:1903052;GO:0031331;GO:1903050;GO:0009987;GO:0019941;GO:0032870;GO:0019752;GO:0044770;GO:0050776;GO:0071363;GO:0050778;GO:0051439;GO:0051438;GO:0045937;GO:0051437;GO:0002474;GO:0002479;GO:0002478;GO:0032989;GO:0071704;GO:0071310;GO:0050851;GO:0050852;GO:0030330;GO:0034612;GO:0006915;GO:0051174;GO:0051171;GO:0044843;GO:0009056;GO:0009057;GO:0000077;GO:0042180;GO:0000075;GO:0051726;GO:0071495;GO:1902589;GO:1901652;GO:1901653;GO:0007093;GO:0080090;GO:1902402;GO:1902403;GO:1902400;GO:0023014;GO:2000134;GO:0010604;GO:0042330;GO:0010608;GO:0043044;GO:0070647;GO:0044419;GO:0060255;GO:0030162;GO:0030163;GO:0051351;GO:0038127;GO:0038061;GO:1901575;GO:1903362;GO:0071356;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:1901987;GO:0036211;GO:0008150;GO:0008152;GO:1901988;GO:0038095;GO:0038093;GO:0051443;GO:1901698;GO:1901699;GO:0045732;GO:0071774;GO:0034728;GO:0016310;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0023051;GO:0007411;GO:0010647;GO:0009653;GO:0007265;GO:0043085;GO:0006997;GO:0031145;GO:0044106;GO:0032268;GO:2000045;GO:0006082;GO:0009725;GO:0043170;GO:0045862;GO:0045860;GO:0000186;GO:0031329;GO:0031325;GO:0031323;GO:1903047;GO:0090304;GO:0010948;GO:0044773;GO:0044774;GO:0032869;GO:0032868;GO:0010941;GO:0071824;GO:1902806;GO:0071822;GO:0071417;GO:0010467;GO:0010468;GO:0048666;GO:0048667;GO:0016032;GO:0006725;GO:0007346;GO:0007154;GO:0042770;GO:0048699;GO:0032990;GO:0007399;GO:1902807;GO:0002253;GO:0001932;GO:0001934; small molecule metabolic process;cellular response to stimulus;reproduction;signal transduction involved in DNA damage checkpoint;MAPK cascade;regulation of cellular amine metabolic process;DNA repair;cell development;regulation of protein kinase activity;germ cell development;spermatogenesis;spermatid development;spermatid nucleus differentiation;neuron projection guidance;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;cellular biogenic amine metabolic process;protein metabolic process;positive regulation of catabolic process;regulation of catabolic process;positive regulation of metabolic process;positive regulation of canonical Wnt signaling pathway;polyamine metabolic process;positive regulation of Wnt signaling pathway;neuron projection development;intracellular signal transduction;regulation of protein serine/threonine kinase activity;signal transduction by p53 class mediator;regulation of biological process;regulation of ligase activity;positive regulation of transferase activity;cell morphogenesis;regulation of cell communication;positive regulation of immune system process;regulation of immune system process;organic cyclic compound metabolic process;antigen processing and presentation;antigen processing and presentation of exogenous antigen;amine metabolic process;positive regulation of MAPK cascade;macromolecule modification;cellular response to cytokine stimulus;spermatogenesis, exchange of chromosomal proteins;sperm chromatin condensation;neuron projection morphogenesis;cellular developmental process;tumor necrosis factor-mediated signaling pathway;multicellular organism development;regulation of protein catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;mitotic G1/S transition checkpoint;regulation of mRNA stability;regulation of RNA stability;histone exchange;innate immune response activating cell surface receptor signaling pathway;stimulatory C-type lectin receptor signaling pathway;insulin receptor signaling pathway;cellular response to DNA damage stimulus;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;axonogenesis;cellular protein catabolic process;chromatin remodeling;cell projection organization;antigen processing and presentation of exogenous peptide antigen via MHC class I;cell cycle process;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;cell death;modification-dependent macromolecule catabolic process;gamete generation;activation of innate immune response;regulation of cellular amino acid metabolic process;cellular amino acid metabolic process;regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of programmed cell death;response to external stimulus;negative regulation of canonical Wnt signaling pathway;protein phosphorylation;positive regulation of innate immune response;regulation of innate immune response;innate immune response;cellular protein modification process;single-organism developmental process;multi-organism cellular process;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;cell projection morphogenesis;anatomical structure development;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;G1/S transition of mitotic cell cycle;activation of protein kinase activity;positive regulation of defense response;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of defense response;single-organism metabolic process;negative regulation of cell cycle;positive regulation of cell cycle;response to growth factor;positive regulation of molecular function;chemotaxis;signal transduction involved in mitotic cell cycle checkpoint;response to organic substance;multi-organism process;cellular catabolic process;immune response-activating cell surface receptor signaling pathway;protein ubiquitination;G1 DNA damage checkpoint;chromatin modification;nitrogen compound metabolic process;antigen processing and presentation of peptide antigen;mitotic cell cycle;cellular protein metabolic process;cellular macromolecule catabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;immune response-regulating cell surface receptor signaling pathway;cellular response to fibroblast growth factor stimulus;cell cycle;regulation of catalytic activity;regulation of cellular process;canonical Wnt signaling pathway;cell morphogenesis involved in differentiation;response to stimulus;proteasomal protein catabolic process;proteasomal ubiquitin-independent protein catabolic process;regulation of transferase activity;ubiquitin-dependent protein catabolic process;signal transduction involved in cell cycle checkpoint;regulation of protein metabolic process;sexual reproduction;regulation of cellular ketone metabolic process;regulation of MAP kinase activity;cellular response to chemical stimulus;protein polyubiquitination;single-organism process;regulation of MAPK cascade;cellular response to peptide hormone stimulus;positive regulation of phosphorus metabolic process;regulation of cell cycle process;positive regulation of protein metabolic process;positive regulation of protein ubiquitination;regulation of protein modification process;regulation of protein ubiquitination;locomotion;multicellular organismal reproductive process;male gamete generation;chromosome organization;signal transduction involved in mitotic G1 DNA damage checkpoint;system development;macromolecular complex subunit organization;mitotic cell cycle phase transition;chromatin organization;DNA packaging;negative regulation of Wnt signaling pathway;positive regulation of cell cycle arrest;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of ubiquitin protein ligase activity;positive regulation of ubiquitin protein ligase activity;regulation of cell cycle arrest;positive regulation of cellular protein catabolic process;negative regulation of mitotic cell cycle;neuron differentiation;reproductive process;cellular process involved in reproduction in multicellular organism;response to chemical;neurogenesis;small GTPase mediated signal transduction;organelle organization;primary metabolic process;cellular metabolic process;DNA metabolic process;symbiosis, encompassing mutualism through parasitism;regulation of phosphate metabolic process;cytokine-mediated signaling pathway;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;protein modification by small protein conjugation;spermatid differentiation;positive regulation of biological process;negative regulation of biological process;neurotrophin signaling pathway;developmental process involved in reproduction;epidermal growth factor receptor signaling pathway;oxoacid metabolic process;response to peptide hormone;single organism signaling;multi-organism reproductive process;single organism reproductive process;organonitrogen compound metabolic process;single-multicellular organism process;response to organonitrogen compound;Wnt signaling pathway;immune system process;cellular response to stress;regulation of canonical Wnt signaling pathway;DNA conformation change;positive regulation of kinase activity;movement of cell or subcellular component;regulation of apoptotic process;signal transduction involved in DNA integrity checkpoint;positive regulation of cell cycle process;DNA integrity checkpoint;mitotic G1 DNA damage checkpoint;regulation of kinase activity;axon development;response to cytokine;defense response;programmed cell death;response to stress;immune response;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;cell cycle arrest;immune response-activating signal transduction;regulation of response to stress;positive regulation of protein modification process;innate immune response-activating signal transduction;cell differentiation;vascular endothelial growth factor receptor signaling pathway;fibroblast growth factor receptor signaling pathway;response to endogenous stimulus;nucleobase-containing compound metabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of protein modification by small protein conjugation or removal;positive regulation of protein modification by small protein conjugation or removal;positive regulation of cellular protein metabolic process;proteolysis;developmental process;multicellular organismal process;multicellular organism reproduction;proteolysis involved in cellular protein catabolic process;positive regulation of proteolysis involved in cellular protein catabolic process;positive regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;cellular response to hormone stimulus;carboxylic acid metabolic process;cell cycle phase transition;regulation of immune response;cellular response to growth factor stimulus;positive regulation of immune response;regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;regulation of ubiquitin-protein transferase activity;positive regulation of phosphate metabolic process;positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition;antigen processing and presentation of peptide antigen via MHC class I;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;antigen receptor-mediated signaling pathway;T cell receptor signaling pathway;DNA damage response, signal transduction by p53 class mediator;response to tumor necrosis factor;apoptotic process;regulation of phosphorus metabolic process;regulation of nitrogen compound metabolic process;cell cycle G1/S phase transition;catabolic process;macromolecule catabolic process;DNA damage checkpoint;cellular ketone metabolic process;cell cycle checkpoint;regulation of cell cycle;cellular response to endogenous stimulus;single-organism organelle organization;response to peptide;cellular response to peptide;mitotic cell cycle checkpoint;regulation of primary metabolic process;signal transduction involved in mitotic DNA damage checkpoint;signal transduction involved in mitotic DNA integrity checkpoint;intracellular signal transduction involved in G1 DNA damage checkpoint;signal transduction by protein phosphorylation;negative regulation of G1/S transition of mitotic cell cycle;positive regulation of macromolecule metabolic process;taxis;posttranscriptional regulation of gene expression;ATP-dependent chromatin remodeling;protein modification by small protein conjugation or removal;interspecies interaction between organisms;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;positive regulation of ligase activity;ERBB signaling pathway;NIK/NF-kappaB signaling;organic substance catabolic process;regulation of cellular protein catabolic process;cellular response to tumor necrosis factor;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;regulation of cell cycle phase transition;protein modification process;biological_process;metabolic process;negative regulation of cell cycle phase transition;Fc-epsilon receptor signaling pathway;Fc receptor signaling pathway;positive regulation of ubiquitin-protein transferase activity;response to nitrogen compound;cellular response to nitrogen compound;positive regulation of protein catabolic process;response to fibroblast growth factor;nucleosome organization;phosphorylation;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;regulation of signaling;axon guidance;positive regulation of cell communication;anatomical structure morphogenesis;Ras protein signal transduction;positive regulation of catalytic activity;nucleus organization;anaphase-promoting complex-dependent catabolic process;cellular amine metabolic process;regulation of cellular protein metabolic process;regulation of G1/S transition of mitotic cell cycle;organic acid metabolic process;response to hormone;macromolecule metabolic process;positive regulation of proteolysis;positive regulation of protein kinase activity;activation of MAPKK activity;regulation of cellular catabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;negative regulation of cell cycle process;mitotic DNA damage checkpoint;mitotic DNA integrity checkpoint;cellular response to insulin stimulus;response to insulin;regulation of cell death;protein-DNA complex subunit organization;regulation of cell cycle G1/S phase transition;protein complex subunit organization;cellular response to organonitrogen compound;gene expression;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;viral process;cellular aromatic compound metabolic process;regulation of mitotic cell cycle;cell communication;signal transduction in response to DNA damage;generation of neurons;cell part morphogenesis;nervous system development;negative regulation of cell cycle G1/S phase transition;activation of immune response;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 4;3;2;7;5;5;4;4;7;4;6;5;5;5;4;7;7;6;4;4;4;3;6;7;5;5;5;8;6;2;5;6;5;4;3;3;4;3;4;5;6;5;6;5;4;6;4;7;4;5;6;6;7;5;4;7;6;7;8;5;7;7;6;7;4;6;4;8;4;6;4;4;5;4;8;5;6;4;5;3;6;7;5;5;4;6;3;3;3;4;5;5;3;5;4;3;3;7;9;4;4;5;6;7;5;3;4;4;5;4;4;6;4;2;4;5;9;7;6;3;4;5;5;5;5;4;6;5;4;4;3;7;5;2;6;7;5;8;5;5;3;5;7;4;10;2;6;6;5;5;5;8;6;8;2;3;5;5;8;4;4;6;5;7;5;6;9;7;8;6;6;5;6;2;4;3;6;6;4;3;3;5;4;6;6;3;3;3;3;5;2;4;4;4;8;4;2;2;6;3;9;5;5;3;3;3;4;3;4;6;2;4;6;6;7;4;6;6;5;6;7;6;6;5;4;5;3;3;7;5;5;5;4;4;6;5;5;8;6;3;4;7;7;7;5;5;2;2;3;6;7;5;7;2;7;5;6;5;4;6;4;6;6;6;7;5;7;5;4;3;5;6;7;7;6;6;5;4;6;3;5;6;4;5;4;4;4;5;6;6;4;7;7;8;4;7;4;3;6;8;7;3;4;6;5;6;8;6;4;6;7;3;2;3;3;6;5;1;2;6;8;7;7;4;5;5;4;6;6;3;3;4;2;4;3;6;4;3;7;5;5;8;5;5;7;4;4;4;6;8;7;5;4;4;5;5;5;6;6;7;6;4;5;7;5;5;5;5;5;6;4;4;5;4;6;7;5;5;7;3;7;7; GO:0044428;GO:0044424;GO:0044422;GO:0016607;GO:0005654;GO:0044464;GO:0070013;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0043227;GO:0016604;GO:0031974;GO:0043229;GO:0005622;GO:0043226;GO:1990111;GO:0031981;GO:0044446;GO:0044444;GO:0005634;GO:0000502;GO:0005737;GO:0044451;GO:0005623;GO:0032991;GO:0005575; nuclear part;intracellular part;organelle part;nuclear speck;nucleoplasm;cell part;intracellular organelle lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;membrane-bounded organelle;nuclear body;membrane-enclosed lumen;intracellular organelle;intracellular;organelle;spermatoproteasome complex;nuclear lumen;intracellular organelle part;cytoplasmic part;nucleus;proteasome complex;cytoplasm;nucleoplasm part;cell;macromolecular complex;cellular_component; 4;3;2;7;5;2;4;3;4;3;5;3;6;2;3;3;2;5;5;3;4;5;4;4;5;2;2;1; GO:0098772;GO:0005488;GO:0030234;GO:0070577;GO:0005515;GO:0008047;GO:0061134;GO:0042393;GO:0003674;GO:0016504; molecular function regulator;binding;enzyme regulator activity;lysine-acetylated histone binding;protein binding;enzyme activator activity;peptidase regulator activity;histone binding;molecular_function;peptidase activator activity; 2;2;3;5;3;4;4;4;1;5; K06699 map03050; Proteasome; IPR021843;IPR035309;IPR016024;IPR011989;IPR032430; Proteasome activator complex subunit 4 C-terminal domain;Proteasome activator complex subunit 4;Armadillo-type fold;Armadillo-like helical;Proteasome activator Blm10, mid region; nucleus Hs14724070 3568.0 S [S] Function unknown; P04004 Vitronectin OS=Homo sapiens OX=9606 GN=VTN PE=1 SV=1 - [VTNC_HUMAN] 1.063 0.987 0.95 1.06 0.985 1.107 1.077001013 0.000464022 1.076142132 3.25E-07 0.962512665 0.382510101 1.123857868 1.52E-09 GO:0070848;GO:0019220;GO:0080090;GO:0019222;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0007160;GO:0050819;GO:0007166;GO:0007167;GO:0007169;GO:0048260;GO:0090287;GO:0044707;GO:0031347;GO:0044710;GO:0010605;GO:0061302;GO:0045785;GO:0009966;GO:0048869;GO:0007369;GO:0018212;GO:0050727;GO:0018193;GO:0044093;GO:0044092;GO:0048518;GO:0065007;GO:0007599;GO:0010604;GO:0031589;GO:0007596;GO:0051050;GO:0060255;GO:2000257;GO:0048731;GO:0032268;GO:0030162;GO:0070887;GO:0023052;GO:0002673;GO:0010033;GO:0042325;GO:0044700;GO:0042327;GO:0065008;GO:0016192;GO:0009605;GO:0048870;GO:0019538;GO:0050730;GO:0071310;GO:0002376;GO:0007154;GO:0030198;GO:0030193;GO:0051128;GO:0030195;GO:0007165;GO:0051716;GO:0030449;GO:0009893;GO:0006468;GO:0014812;GO:0006928;GO:0002920;GO:0050789;GO:0044267;GO:0032092;GO:0010646;GO:0051346;GO:0044260;GO:0016043;GO:0052548;GO:0002684;GO:1900047;GO:0002682;GO:0071840;GO:0065009;GO:0016477;GO:0048646;GO:0051130;GO:0050790;GO:0006810;GO:0048709;GO:0042063;GO:0042060;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0006956;GO:0006954;GO:0006955;GO:0002526;GO:0048259;GO:0006959;GO:0035987;GO:0045861;GO:0051336;GO:0051174;GO:0070613;GO:0006897;GO:0051604;GO:0030947;GO:0030949;GO:0050896;GO:0006898;GO:0043412;GO:0002697;GO:0050817;GO:2000145;GO:2000147;GO:0009967;GO:0008150;GO:1903317;GO:0007492;GO:0032102;GO:0008152;GO:0032101;GO:0016310;GO:0030155;GO:0030154;GO:0009611;GO:0023056;GO:0010951;GO:0043393;GO:0010001;GO:0023051;GO:0009892;GO:0010647;GO:0009653;GO:0043086;GO:0044699;GO:0007417;GO:0051248;GO:0051234;GO:0001706;GO:0001704;GO:0050818;GO:0010562;GO:0051241;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0006508;GO:0022610;GO:1903034;GO:1903035;GO:1903036;GO:0032502;GO:0014909;GO:0050878;GO:0044238;GO:0031323;GO:0009987;GO:0060627;GO:0051270;GO:0048519;GO:0016485;GO:0048010;GO:0032879;GO:0032269;GO:0050776;GO:0071363;GO:0007399;GO:0051099;GO:0051098;GO:0050778;GO:0043170;GO:0051239;GO:0051674;GO:0009790;GO:0080134;GO:0031401;GO:1900046;GO:0014911;GO:0014910;GO:0031325;GO:0031324;GO:0018108;GO:0061041;GO:0032501;GO:0061045;GO:0090303;GO:0050731;GO:0007275;GO:0009888;GO:0072376;GO:0071704;GO:0010467;GO:0010466;GO:0043062;GO:0010468;GO:0033627;GO:0048598;GO:0030335;GO:0030334;GO:0045937;GO:0052547;GO:0010810;GO:0010811;GO:0045087;GO:0006793;GO:0006464;GO:0044767;GO:0044763;GO:0007155;GO:0042221;GO:0022008;GO:0030100;GO:0051179;GO:0040011;GO:0051272;GO:0040012;GO:0040017;GO:0048856;GO:0044237;GO:0006796;GO:0002253;GO:0002252;GO:0045807;GO:0001932;GO:0001934;GO:0048523;GO:0048522; response to growth factor;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;cell-matrix adhesion;negative regulation of coagulation;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of receptor-mediated endocytosis;regulation of cellular response to growth factor stimulus;single-multicellular organism process;regulation of defense response;single-organism metabolic process;negative regulation of macromolecule metabolic process;smooth muscle cell-matrix adhesion;positive regulation of cell adhesion;regulation of signal transduction;cellular developmental process;gastrulation;peptidyl-tyrosine modification;regulation of inflammatory response;peptidyl-amino acid modification;positive regulation of molecular function;negative regulation of molecular function;positive regulation of biological process;biological regulation;hemostasis;positive regulation of macromolecule metabolic process;cell-substrate adhesion;blood coagulation;positive regulation of transport;regulation of macromolecule metabolic process;regulation of protein activation cascade;system development;regulation of cellular protein metabolic process;regulation of proteolysis;cellular response to chemical stimulus;signaling;regulation of acute inflammatory response;response to organic substance;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;regulation of biological quality;vesicle-mediated transport;response to external stimulus;cell motility;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;cellular response to organic substance;immune system process;cell communication;extracellular matrix organization;regulation of blood coagulation;regulation of cellular component organization;negative regulation of blood coagulation;signal transduction;cellular response to stimulus;regulation of complement activation;positive regulation of metabolic process;protein phosphorylation;muscle cell migration;movement of cell or subcellular component;regulation of humoral immune response;regulation of biological process;cellular protein metabolic process;positive regulation of protein binding;regulation of cell communication;negative regulation of hydrolase activity;cellular macromolecule metabolic process;cellular component organization;regulation of endopeptidase activity;positive regulation of immune system process;negative regulation of hemostasis;regulation of immune system process;cellular component organization or biogenesis;regulation of molecular function;cell migration;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;regulation of catalytic activity;transport;oligodendrocyte differentiation;gliogenesis;wound healing;regulation of cellular process;defense response;response to stress;protein modification process;complement activation;inflammatory response;immune response;acute inflammatory response;regulation of receptor-mediated endocytosis;humoral immune response;endodermal cell differentiation;negative regulation of proteolysis;regulation of hydrolase activity;regulation of phosphorus metabolic process;regulation of protein processing;endocytosis;protein maturation;regulation of vascular endothelial growth factor receptor signaling pathway;positive regulation of vascular endothelial growth factor receptor signaling pathway;response to stimulus;receptor-mediated endocytosis;macromolecule modification;regulation of immune effector process;coagulation;regulation of cell motility;positive regulation of cell motility;positive regulation of signal transduction;biological_process;regulation of protein maturation;endoderm development;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;phosphorylation;regulation of cell adhesion;cell differentiation;response to wounding;positive regulation of signaling;negative regulation of endopeptidase activity;regulation of protein binding;glial cell differentiation;regulation of signaling;negative regulation of metabolic process;positive regulation of cell communication;anatomical structure morphogenesis;negative regulation of catalytic activity;single-organism process;central nervous system development;negative regulation of protein metabolic process;establishment of localization;endoderm formation;formation of primary germ layer;regulation of coagulation;positive regulation of phosphorus metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;proteolysis;biological adhesion;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;developmental process;smooth muscle cell migration;regulation of body fluid levels;primary metabolic process;regulation of cellular metabolic process;cellular process;regulation of vesicle-mediated transport;regulation of cellular component movement;negative regulation of biological process;protein processing;vascular endothelial growth factor receptor signaling pathway;regulation of localization;negative regulation of cellular protein metabolic process;regulation of immune response;cellular response to growth factor stimulus;nervous system development;positive regulation of binding;regulation of binding;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;localization of cell;embryo development;regulation of response to stress;positive regulation of protein modification process;regulation of hemostasis;positive regulation of smooth muscle cell migration;regulation of smooth muscle cell migration;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;regulation of wound healing;multicellular organismal process;negative regulation of wound healing;positive regulation of wound healing;positive regulation of peptidyl-tyrosine phosphorylation;multicellular organism development;tissue development;protein activation cascade;organic substance metabolic process;gene expression;negative regulation of peptidase activity;extracellular structure organization;regulation of gene expression;cell adhesion mediated by integrin;embryonic morphogenesis;positive regulation of cell migration;regulation of cell migration;positive regulation of phosphate metabolic process;regulation of peptidase activity;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;innate immune response;phosphorus metabolic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell adhesion;response to chemical;neurogenesis;regulation of endocytosis;localization;locomotion;positive regulation of cellular component movement;regulation of locomotion;positive regulation of locomotion;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;activation of immune response;immune effector process;positive regulation of endocytosis;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 5;6;4;3;4;3;3;3;5;4;5;6;7;5;4;3;5;3;4;6;4;4;4;5;8;5;7;4;4;2;2;5;4;4;5;3;4;4;4;5;6;4;2;6;4;7;3;7;3;5;3;3;4;8;5;2;4;5;5;4;5;4;3;5;3;7;5;4;5;2;5;6;4;6;4;3;7;3;4;3;2;3;4;3;4;4;4;6;7;5;3;4;3;5;4;5;3;6;6;4;6;6;5;5;7;6;5;5;5;2;7;5;4;4;4;4;4;1;6;5;4;2;4;6;4;5;4;3;8;5;6;3;3;4;3;5;2;5;5;3;5;4;4;5;3;5;5;5;6;5;2;5;4;4;2;6;4;3;4;2;4;4;2;6;8;3;5;4;6;5;5;4;4;4;3;3;5;4;6;4;6;6;4;4;8;6;2;5;5;8;4;4;3;3;5;7;4;5;4;4;5;5;6;6;5;5;4;4;6;3;3;3;3;6;5;2;2;4;3;3;3;3;5;3;3;4;7;7;3;3; GO:0072562;GO:0043234;GO:0031012;GO:0043230;GO:0044421;GO:0043227;GO:0031982;GO:0016020;GO:0044459;GO:0044464;GO:0005623;GO:0098797;GO:0005615;GO:0043226;GO:0044425;GO:0071062;GO:0071944;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005578;GO:0005575;GO:0098796;GO:0005576; blood microparticle;protein complex;extracellular matrix;extracellular organelle;extracellular region part;membrane-bounded organelle;vesicle;membrane;plasma membrane part;cell part;cell;plasma membrane protein complex;extracellular space;organelle;membrane part;alphav-beta3 integrin-vitronectin complex;cell periphery;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;proteinaceous extracellular matrix;cellular_component;membrane protein complex;extracellular region; 3;3;2;3;2;3;4;2;3;2;2;4;3;2;2;5;3;3;3;4;2;3;1;3;2; GO:0050840;GO:0060089;GO:0050839;GO:0097367;GO:0003674;GO:0005488;GO:1901681;GO:0005539;GO:0001871;GO:0038024;GO:0043168;GO:0043167;GO:0032403;GO:0008201;GO:0005515;GO:0044877;GO:0005102;GO:0030247;GO:0030246;GO:0004872;GO:0005178;GO:0005044; extracellular matrix binding;molecular transducer activity;cell adhesion molecule binding;carbohydrate derivative binding;molecular_function;binding;sulfur compound binding;glycosaminoglycan binding;pattern binding;cargo receptor activity;anion binding;ion binding;protein complex binding;heparin binding;protein binding;macromolecular complex binding;receptor binding;polysaccharide binding;carbohydrate binding;receptor activity;integrin binding;scavenger receptor activity; 3;2;4;3;1;2;3;4;3;4;4;3;4;4;3;3;4;4;3;3;5;5; K06251 map04151;map04510;map04512;map04610;map05205; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Complement and coagulation cascades;Proteoglycans in cancer; IPR018487;IPR018486;IPR000585;IPR020436;IPR001212; Hemopexin-like repeats;Hemopexin, conserved site;Hemopexin-like domain;Somatomedin B, chordata;Somatomedin B domain; extracellular Hs18201911 995.0 OW [O] Posttranslational modification, protein turnover, chaperones;[W] Extracellular structures; O75691 Small subunit processome component 20 homolog OS=Homo sapiens OX=9606 GN=UTP20 PE=1 SV=3 - [UTP20_HUMAN] 0.816 0.787 1.492 0.987 0.926 1.297 1.036848793 nan 1.06587473 nan 1.895806862 nan 1.400647948 nan GO:0071840;GO:0048519;GO:0006364;GO:0042127;GO:0034470;GO:0034471;GO:0000460;GO:0000462;GO:0000466;GO:0000469;GO:0046483;GO:0034660;GO:0000479;GO:0000478;GO:0044260;GO:0042254;GO:0065007;GO:1901360;GO:0050794;GO:0008150;GO:0008152;GO:0016070;GO:0016072;GO:0042274;GO:0000480;GO:0034641;GO:0044699;GO:0006139;GO:0000967;GO:0000966;GO:0022613;GO:0008285;GO:0008283;GO:0009987;GO:0006725;GO:0090502;GO:0090501;GO:0030490;GO:0043170;GO:0006807;GO:0000472;GO:0090304;GO:0090305;GO:0050789;GO:0071704;GO:0010467;GO:0000447;GO:0044238;GO:0044237;GO:0044085;GO:0048523;GO:0006396; cellular component organization or biogenesis;negative regulation of biological process;rRNA processing;regulation of cell proliferation;ncRNA processing;ncRNA 5'-end processing;maturation of 5.8S rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);cleavage involved in rRNA processing;heterocycle metabolic process;ncRNA metabolic process;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage involved in rRNA processing;cellular macromolecule metabolic process;ribosome biogenesis;biological regulation;organic cyclic compound metabolic process;regulation of cellular process;biological_process;metabolic process;RNA metabolic process;rRNA metabolic process;ribosomal small subunit biogenesis;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);cellular nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;rRNA 5'-end processing;RNA 5'-end processing;ribonucleoprotein complex biogenesis;negative regulation of cell proliferation;cell proliferation;cellular process;cellular aromatic compound metabolic process;RNA phosphodiester bond hydrolysis, endonucleolytic;RNA phosphodiester bond hydrolysis;maturation of SSU-rRNA;macromolecule metabolic process;nitrogen compound metabolic process;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;regulation of biological process;organic substance metabolic process;gene expression;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);primary metabolic process;cellular metabolic process;cellular component biogenesis;negative regulation of cellular process;RNA processing; 2;2;6;4;7;8;7;7;8;7;4;6;8;7;4;5;2;4;3;1;2;5;7;5;8;4;2;4;7;7;4;4;3;2;4;7;6;6;4;3;8;5;6;2;3;5;8;3;3;3;3;6; GO:0031974;GO:0030529;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0030688;GO:1990904;GO:0030686;GO:0030684;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0032040;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;intracellular ribonucleoprotein complex;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;preribosome, small subunit precursor;ribonucleoprotein complex;90S preribosome;preribosome;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleolus;nucleus;cell part;cell;small-subunit processome;macromolecular complex;cellular_component;intracellular organelle lumen; 2;4;5;4;4;3;4;3;2;6;3;6;5;3;3;3;3;2;5;3;4;5;5;2;2;6;2;1;4; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0044822;GO:0003723; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;poly(A) RNA binding;RNA binding; 3;1;2;4;3;6;5; K14772 IPR011430;IPR016024;IPR011989; Down-regulated-in-metastasis protein;Armadillo-type fold;Armadillo-like helical; nucleus Hs7657041 5716.0 V [V] Defense mechanisms; Q7Z3E1 Protein mono-ADP-ribosyltransferase TIPARP OS=Homo sapiens OX=9606 GN=TIPARP PE=1 SV=1 - [PARPT_HUMAN] 1.011 1.409 0.581 0.919 1.501 0.399 0.717530163 0.027586773 0.612258494 0.073067008 0.412349184 0.015673519 0.265822785 0.046996757 GO:0008209;GO:0080090;GO:0019222;GO:0006471;GO:0008585;GO:0001501;GO:0060323;GO:0060322;GO:0060325;GO:0060324;GO:0007166;GO:0007167;GO:0007169;GO:0072001;GO:1901360;GO:0042445;GO:0044710;GO:0010605;GO:0000003;GO:0048869;GO:0001822;GO:0045137;GO:0048513;GO:0048514;GO:0048518;GO:0048519;GO:0044700;GO:0060255;GO:0003006;GO:0030163;GO:0010033;GO:0044702;GO:0044707;GO:0019538;GO:0072359;GO:0050789;GO:0072358;GO:0007165;GO:0009896;GO:0009894;GO:0051716;GO:0009892;GO:0070887;GO:0010629;GO:0006807;GO:0044267;GO:1901575;GO:0044260;GO:0001568;GO:0008406;GO:0065007;GO:0014070;GO:0065008;GO:0048705;GO:0009887;GO:0046545;GO:0006629;GO:0048745;GO:0009888;GO:0071310;GO:0043412;GO:0043413;GO:0008150;GO:0008152;GO:0030097;GO:0044723;GO:0050794;GO:0046660;GO:0010604;GO:0001570;GO:0007548;GO:0050896;GO:0045732;GO:0036211;GO:0048008;GO:0051246;GO:0030154;GO:0009791;GO:0044249;GO:0042176;GO:0023052;GO:0034645;GO:0007154;GO:0009653;GO:0044699;GO:0009893;GO:0001944;GO:0051247;GO:0002520;GO:0032502;GO:0032501;GO:0048608;GO:0009987;GO:0001655;GO:0010171;GO:0008202;GO:1901137;GO:0071407;GO:1901135;GO:0043170;GO:0048731;GO:0061458;GO:0002376;GO:0060021;GO:0008210;GO:0009100;GO:0009101;GO:0006486;GO:0007275;GO:0071704;GO:0010467;GO:0048534;GO:0010468;GO:1901576;GO:0034754;GO:0070085;GO:0006464;GO:0010817;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0042221;GO:0009056;GO:0009057;GO:0044238;GO:0005975;GO:0048856;GO:0044237;GO:0044236;GO:0060537; androgen metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein ADP-ribosylation;female gonad development;skeletal system development;head morphogenesis;head development;face morphogenesis;face development;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;renal system development;organic cyclic compound metabolic process;hormone metabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;reproduction;cellular developmental process;kidney development;development of primary sexual characteristics;animal organ development;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;single organism signaling;regulation of macromolecule metabolic process;developmental process involved in reproduction;protein catabolic process;response to organic substance;single organism reproductive process;single-multicellular organism process;protein metabolic process;circulatory system development;regulation of biological process;cardiovascular system development;signal transduction;positive regulation of catabolic process;regulation of catabolic process;cellular response to stimulus;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of gene expression;nitrogen compound metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;blood vessel development;gonad development;biological regulation;response to organic cyclic compound;regulation of biological quality;skeletal system morphogenesis;organ morphogenesis;development of primary female sexual characteristics;lipid metabolic process;smooth muscle tissue development;tissue development;cellular response to organic substance;macromolecule modification;macromolecule glycosylation;biological_process;metabolic process;hemopoiesis;single-organism carbohydrate metabolic process;regulation of cellular process;female sex differentiation;positive regulation of macromolecule metabolic process;vasculogenesis;sex differentiation;response to stimulus;positive regulation of protein catabolic process;protein modification process;platelet-derived growth factor receptor signaling pathway;regulation of protein metabolic process;cell differentiation;post-embryonic development;cellular biosynthetic process;regulation of protein catabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;anatomical structure morphogenesis;single-organism process;positive regulation of metabolic process;vasculature development;positive regulation of protein metabolic process;immune system development;developmental process;multicellular organismal process;reproductive structure development;cellular process;urogenital system development;body morphogenesis;steroid metabolic process;carbohydrate derivative biosynthetic process;cellular response to organic cyclic compound;carbohydrate derivative metabolic process;macromolecule metabolic process;system development;reproductive system development;immune system process;palate development;estrogen metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;multicellular organism development;organic substance metabolic process;gene expression;hematopoietic or lymphoid organ development;regulation of gene expression;organic substance biosynthetic process;cellular hormone metabolic process;glycosylation;cellular protein modification process;regulation of hormone levels;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;response to chemical;catabolic process;macromolecule catabolic process;primary metabolic process;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;multicellular organism metabolic process;muscle tissue development; 4;4;3;5;5;5;4;4;4;4;5;6;7;5;4;3;3;4;2;4;4;4;4;4;2;2;3;4;3;5;4;3;3;4;5;2;5;4;4;4;3;3;4;5;3;5;4;4;4;4;2;5;3;5;4;5;4;6;4;5;5;6;1;2;5;4;3;5;4;5;4;2;5;5;8;5;5;4;4;5;2;5;4;3;2;3;5;5;3;2;2;4;2;5;4;5;5;6;4;4;4;5;2;4;4;5;6;4;4;3;5;4;5;4;4;5;6;4;3;2;3;5;3;3;3;5;3;4;3;3;4;5; GO:0043231;GO:0044424;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular;membrane-bounded organelle;organelle;nucleus;cell part;intracellular organelle;cell;cellular_component; 4;3;3;3;2;5;2;3;2;1; GO:0016740;GO:0046872;GO:0001067;GO:0044212;GO:0016757;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901363;GO:0016763;GO:0003824;GO:0097159;GO:0000975;GO:0003950;GO:0043169;GO:0043167;GO:0035326; transferase activity;metal ion binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;transferase activity, transferring glycosyl groups;molecular_function;binding;nucleic acid binding;DNA binding;heterocyclic compound binding;transferase activity, transferring pentosyl groups;catalytic activity;organic cyclic compound binding;regulatory region DNA binding;NAD+ ADP-ribosyltransferase activity;cation binding;ion binding;enhancer binding; 3;5;5;7;4;1;2;4;5;3;5;2;3;6;6;4;3;8; K15259 IPR012317;IPR004170;IPR000571; Poly(ADP-ribose) polymerase, catalytic domain;WWE domain;Zinc finger, CCCH-type; nucleus Q9NS75 Cysteinyl leukotriene receptor 2 OS=Homo sapiens OX=9606 GN=CYSLTR2 PE=1 SV=1 - [CLTR2_HUMAN] 0.909 1.474 0.579 1.012 1.279 1.189 0.616689281 nan 0.791243159 nan 0.392808684 nan 0.929632525 nan GO:0019220;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0072359;GO:0007165;GO:0023014;GO:0007218;GO:0010604;GO:0009966;GO:0009967;GO:0000165;GO:0048514;GO:0048518;GO:0060255;GO:0042325;GO:0044700;GO:0042327;GO:0044707;GO:0019538;GO:0007200;GO:0002376;GO:0072358;GO:0044710;GO:0009893;GO:0022603;GO:1901342;GO:0035556;GO:0050789;GO:0008219;GO:0044267;GO:0010646;GO:0044260;GO:0001568;GO:0065007;GO:0007186;GO:0048646;GO:0050793;GO:0051716;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0051239;GO:0006955;GO:1902533;GO:1902531;GO:0051174;GO:0050896;GO:0031401;GO:0010562;GO:0008152;GO:0051246;GO:0016310;GO:0023056;GO:0023052;GO:0023051;GO:0010647;GO:0009653;GO:0044699;GO:0043408;GO:1904018;GO:0051240;GO:0001944;GO:0051247;GO:0032270;GO:0031399;GO:0032502;GO:0032501;GO:0009987;GO:0032268;GO:0051094;GO:0043170;GO:0048731;GO:0070374;GO:0070372;GO:0070371;GO:0031325;GO:0031323;GO:0010942;GO:0001525;GO:0007275;GO:0010941;GO:0045765;GO:0045766;GO:0006796;GO:0071704;GO:0006468;GO:0045937;GO:0006464;GO:0044767;GO:0044763;GO:0007154;GO:0044238;GO:0048856;GO:0044237;GO:2000026;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;signal transduction;signal transduction by protein phosphorylation;neuropeptide signaling pathway;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;blood vessel morphogenesis;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;single-multicellular organism process;protein metabolic process;phospholipase C-activating G-protein coupled receptor signaling pathway;immune system process;cardiovascular system development;single-organism metabolic process;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;regulation of vasculature development;intracellular signal transduction;regulation of biological process;cell death;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;blood vessel development;biological regulation;G-protein coupled receptor signaling pathway;anatomical structure formation involved in morphogenesis;regulation of developmental process;cellular response to stimulus;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;regulation of multicellular organismal process;immune response;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of phosphorus metabolic process;response to stimulus;positive regulation of protein modification process;positive regulation of phosphorus metabolic process;metabolic process;regulation of protein metabolic process;phosphorylation;positive regulation of signaling;signaling;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;regulation of MAPK cascade;positive regulation of vasculature development;positive regulation of multicellular organismal process;vasculature development;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;developmental process;multicellular organismal process;cellular process;regulation of cellular protein metabolic process;positive regulation of developmental process;macromolecule metabolic process;system development;positive regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;positive regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of cell death;angiogenesis;multicellular organism development;regulation of cell death;regulation of angiogenesis;positive regulation of angiogenesis;phosphate-containing compound metabolic process;organic substance metabolic process;protein phosphorylation;positive regulation of phosphate metabolic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell communication;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;4;3;3;3;5;4;4;6;4;4;4;5;4;2;4;7;3;7;3;4;6;2;5;3;3;4;5;5;2;4;5;4;4;4;2;5;3;3;3;3;6;5;5;1;3;3;5;5;5;2;6;5;2;5;6;3;2;3;4;3;2;6;4;3;5;5;5;6;2;2;2;5;3;4;4;7;7;6;4;4;4;4;4;4;5;5;5;3;7;6;6;3;3;4;3;3;3;4;4;7;7;3; GO:0016021;GO:0016020;GO:0044425;GO:0031224;GO:0031226;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0005887;GO:0005886;GO:0005575; integral component of membrane;membrane;membrane part;intrinsic component of membrane;intrinsic component of plasma membrane;plasma membrane part;cell part;cell;cell periphery;integral component of plasma membrane;plasma membrane;cellular_component; 4;2;2;3;4;3;2;2;3;4;3;1; GO:0060089;GO:0004953;GO:0099600;GO:0003674;GO:0004930;GO:0001653;GO:0038023;GO:0004872;GO:0004871;GO:0004974;GO:0008528;GO:0001631;GO:0004888; molecular transducer activity;icosanoid receptor activity;transmembrane receptor activity;molecular_function;G-protein coupled receptor activity;peptide receptor activity;signaling receptor activity;receptor activity;signal transducer activity;leukotriene receptor activity;G-protein coupled peptide receptor activity;cysteinyl leukotriene receptor activity;transmembrane signaling receptor activity; 2;6;4;1;5;4;3;3;2;7;5;8;4; K04323 map04020;map04080; Calcium signaling pathway;Neuroactive ligand-receptor interaction; IPR017452;IPR000276;IPR004071;IPR013311; GPCR, rhodopsin-like, 7TM;G protein-coupled receptor, rhodopsin-like;Cysteinyl leukotriene receptor;Cysteinyl leukotriene receptor 2; plasma membrane P69905 Hemoglobin subunit alpha OS=Homo sapiens OX=9606 GN=HBA1 PE=1 SV=2 - [HBA_HUMAN] 0.847 1.063 1.071 1.074 1.155 0.796 0.796801505 2.44E-31 0.92987013 0.000968802 1.00752587 0.330895314 0.689177489 0.131752627 GO:0005833;GO:0005737;GO:0043234;GO:0032991;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044445;GO:0044424; hemoglobin complex;cytoplasm;protein complex;macromolecular complex;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;cytosolic part;intracellular part; 4;4;3;2;5;2;2;3;1;4;5;3; GO:0005344;GO:0003674;GO:0005488;GO:1901363;GO:0043169;GO:0046914;GO:0043167;GO:0005506;GO:0046872;GO:0020037;GO:0005215;GO:0022892;GO:0019825;GO:0046906;GO:0097159; oxygen transporter activity;molecular_function;binding;heterocyclic compound binding;cation binding;transition metal ion binding;ion binding;iron ion binding;metal ion binding;heme binding;transporter activity;substrate-specific transporter activity;oxygen binding;tetrapyrrole binding;organic cyclic compound binding; 4;1;2;3;4;6;3;7;5;5;2;3;3;4;3; K13822 map05143;map05144; African trypanosomiasis;Malaria; IPR000971;IPR002338;IPR009050;IPR002339; Globin;Haemoglobin, alpha-type;Globin-like;Haemoglobin, pi; cytosol Hs4504345 286.0 C [C] Energy production and conversion; P13598 Intercellular adhesion molecule 2 OS=Homo sapiens OX=9606 GN=ICAM2 PE=1 SV=2 - [ICAM2_HUMAN] 1.198 0.982 0.828 1.006 1.02 1.625 1.219959267 nan 0.98627451 nan 0.843177189 nan 1.593137255 nan GO:0016337;GO:0002429;GO:0048583;GO:0031349;GO:0080134;GO:0007166;GO:0002220;GO:0023052;GO:0002253;GO:0050789;GO:0044699;GO:0048584;GO:0051716;GO:0002218;GO:0016043;GO:0002684;GO:0030198;GO:0002682;GO:0071840;GO:0043062;GO:0065007;GO:0022610;GO:0002223;GO:0098602;GO:0045089;GO:0045088;GO:0098609;GO:0045087;GO:0009987;GO:0050794;GO:0006952;GO:0048518;GO:0006950;GO:0002757;GO:0008150;GO:0002758;GO:0006955;GO:0007155;GO:0007154;GO:0031347;GO:0044700;GO:0050776;GO:0002768;GO:0050896;GO:0044763;GO:0050778;GO:0002376;GO:0002764;GO:0007165; single organismal cell-cell adhesion;immune response-activating cell surface receptor signaling pathway;regulation of response to stimulus;positive regulation of defense response;regulation of response to stress;cell surface receptor signaling pathway;innate immune response activating cell surface receptor signaling pathway;signaling;activation of immune response;regulation of biological process;single-organism process;positive regulation of response to stimulus;cellular response to stimulus;activation of innate immune response;cellular component organization;positive regulation of immune system process;extracellular matrix organization;regulation of immune system process;cellular component organization or biogenesis;extracellular structure organization;biological regulation;biological adhesion;stimulatory C-type lectin receptor signaling pathway;single organism cell adhesion;positive regulation of innate immune response;regulation of innate immune response;cell-cell adhesion;innate immune response;cellular process;regulation of cellular process;defense response;positive regulation of biological process;response to stress;immune response-activating signal transduction;biological_process;innate immune response-activating signal transduction;immune response;cell adhesion;cell communication;regulation of defense response;single organism signaling;regulation of immune response;immune response-regulating cell surface receptor signaling pathway;response to stimulus;single-organism cellular process;positive regulation of immune response;immune system process;immune response-regulating signaling pathway;signal transduction; 4;5;3;4;4;5;6;2;3;2;2;3;3;4;3;3;5;3;2;4;2;2;7;3;5;5;4;4;2;3;4;2;3;4;1;5;3;3;4;5;3;4;6;2;3;4;2;5;4; GO:0042995;GO:0044464;GO:0005886;GO:0031224;GO:0071944;GO:0043227;GO:0005575;GO:1903561;GO:0070062;GO:0031226;GO:0016021;GO:0016020;GO:0043226;GO:0044425;GO:0044459;GO:0005887;GO:0031982;GO:0043230;GO:0005623;GO:0005576;GO:0031254;GO:0001931;GO:0044421; cell projection;cell part;plasma membrane;intrinsic component of membrane;cell periphery;membrane-bounded organelle;cellular_component;extracellular vesicle;extracellular exosome;intrinsic component of plasma membrane;integral component of membrane;membrane;organelle;membrane part;plasma membrane part;integral component of plasma membrane;vesicle;extracellular organelle;cell;extracellular region;cell trailing edge;uropod;extracellular region part; 3;2;3;3;3;3;1;3;4;4;4;2;2;2;3;4;4;3;2;2;3;4;2; GO:0044877;GO:0005488;GO:0032403;GO:0005178;GO:0050839;GO:0005515;GO:0003674;GO:0005102; macromolecular complex binding;binding;protein complex binding;integrin binding;cell adhesion molecule binding;protein binding;molecular_function;receptor binding; 3;2;4;5;4;3;1;4; K06523 map04514;map04650; Cell adhesion molecules (CAMs);Natural killer cell mediated cytotoxicity; IPR007110;IPR013783;IPR013768;IPR003987;IPR015653;IPR003988; Immunoglobulin-like domain;Immunoglobulin-like fold;Intercellular adhesion molecule, N-terminal;Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal;Intercellular adhesion molecule 2;Intercellular adhesion molecule; extracellular Q9BV20 Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1 - [MTNA_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0044281;GO:0044283;GO:1901360;GO:0044710;GO:0044711;GO:0019509;GO:0046500;GO:0000097;GO:0000096;GO:0043436;GO:0046128;GO:0046483;GO:1901564;GO:0016053;GO:0071267;GO:0071265;GO:0006807;GO:0009066;GO:0009069;GO:0046498;GO:1901576;GO:0051186;GO:0009308;GO:0008150;GO:0008152;GO:0006575;GO:0043094;GO:0008652;GO:0044272;GO:0046394;GO:0006576;GO:0006732;GO:0044249;GO:0034641;GO:1901566;GO:0044699;GO:0006139;GO:0042278;GO:1901605;GO:1901607;GO:0009987;GO:0006725;GO:0044106;GO:0006595;GO:0055086;GO:0006082;GO:1901135;GO:0009067;GO:0009086;GO:0019752;GO:0072521;GO:0019284;GO:1901657;GO:0006520;GO:0071704;GO:0033353;GO:0043102;GO:0009058;GO:0044763;GO:0009116;GO:0009119;GO:0044238;GO:0006555;GO:0044237;GO:0006790; small molecule metabolic process;small molecule biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;L-methionine biosynthetic process from methylthioadenosine;S-adenosylmethionine metabolic process;sulfur amino acid biosynthetic process;sulfur amino acid metabolic process;oxoacid metabolic process;purine ribonucleoside metabolic process;heterocycle metabolic process;organonitrogen compound metabolic process;organic acid biosynthetic process;L-methionine salvage;L-methionine biosynthetic process;nitrogen compound metabolic process;aspartate family amino acid metabolic process;serine family amino acid metabolic process;S-adenosylhomocysteine metabolic process;organic substance biosynthetic process;cofactor metabolic process;amine metabolic process;biological_process;metabolic process;cellular modified amino acid metabolic process;cellular metabolic compound salvage;cellular amino acid biosynthetic process;sulfur compound biosynthetic process;carboxylic acid biosynthetic process;cellular biogenic amine metabolic process;coenzyme metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;organonitrogen compound biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;purine nucleoside metabolic process;alpha-amino acid metabolic process;alpha-amino acid biosynthetic process;cellular process;cellular aromatic compound metabolic process;cellular amine metabolic process;polyamine metabolic process;nucleobase-containing small molecule metabolic process;organic acid metabolic process;carbohydrate derivative metabolic process;aspartate family amino acid biosynthetic process;methionine biosynthetic process;carboxylic acid metabolic process;purine-containing compound metabolic process;L-methionine biosynthetic process from S-adenosylmethionine;glycosyl compound metabolic process;cellular amino acid metabolic process;organic substance metabolic process;S-adenosylmethionine cycle;amino acid salvage;biosynthetic process;single-organism cellular process;nucleoside metabolic process;ribonucleoside metabolic process;primary metabolic process;methionine metabolic process;cellular metabolic process;sulfur compound metabolic process; 4;5;4;3;4;8;5;6;5;5;7;4;4;5;7;8;3;6;6;5;4;4;5;1;2;4;5;5;5;6;6;5;4;4;5;2;4;6;5;6;2;4;5;7;4;4;4;7;7;6;5;6;4;4;3;6;6;3;3;5;6;3;6;3;4; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0042995;GO:0043229;GO:0043227;GO:0043226;GO:0044446;GO:0044444;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;cell projection;intracellular organelle;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasmic part;cytoplasm;nucleolus;nucleus;cell part;cell;intracellular;non-membrane-bounded organelle;cellular_component;intracellular organelle lumen; 2;5;4;4;3;5;4;3;2;3;3;3;2;3;4;4;5;5;2;2;3;3;1;4; GO:0016860;GO:0003674;GO:0046523;GO:0016861;GO:0003824;GO:0016853;GO:0042802;GO:0005515;GO:0005488; intramolecular oxidoreductase activity;molecular_function;S-methyl-5-thioribose-1-phosphate isomerase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;catalytic activity;isomerase activity;identical protein binding;protein binding;binding; 4;1;6;5;2;3;4;3;2; K08963 map00270;map01100; Cysteine and methionine metabolism;Metabolic pathways; IPR000649;IPR027363;IPR005251;IPR011559; Initiation factor 2B-related;Methylthioribose-1-phosphate isomerase-like, N-terminal domain;Methylthioribose-1-phosphate isomerase;Initiation factor 2B alpha/beta/delta; mitochondria Hs22051459 745.0 J [J] Translation, ribosomal structure and biogenesis; O60282 Kinesin heavy chain isoform 5C OS=Homo sapiens OX=9606 GN=KIF5C PE=1 SV=1 - [KIF5C_HUMAN] 1.036 0.843 1.419 1.004 0.841 0.842 1.228944247 nan 1.193816885 nan 1.683274021 nan 1.001189061 nan GO:0008104;GO:0048468;GO:0071840;GO:0097485;GO:0042330;GO:0048869;GO:0033036;GO:0006935;GO:0009605;GO:0044707;GO:0006928;GO:0051028;GO:0000904;GO:0000902;GO:0016043;GO:0061564;GO:0006810;GO:0008150;GO:0051236;GO:0051234;GO:0050658;GO:0046907;GO:0050896;GO:0050657;GO:0048812;GO:0015931;GO:0030154;GO:0007411;GO:0009653;GO:0044699;GO:0030705;GO:0032502;GO:0006996;GO:0032501;GO:0009987;GO:0007409;GO:0048858;GO:0048731;GO:0030030;GO:0031175;GO:0008045;GO:0007275;GO:0032989;GO:0071705;GO:0071702;GO:0006403;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0042221;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0048699;GO:0007017;GO:0032990;GO:0007399;GO:0048856;GO:0007018;GO:1902582; protein localization;cell development;cellular component organization or biogenesis;neuron projection guidance;taxis;cellular developmental process;macromolecule localization;chemotaxis;response to external stimulus;single-multicellular organism process;movement of cell or subcellular component;mRNA transport;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;axon development;transport;biological_process;establishment of RNA localization;establishment of localization;RNA transport;intracellular transport;response to stimulus;nucleic acid transport;neuron projection morphogenesis;nucleobase-containing compound transport;cell differentiation;axon guidance;anatomical structure morphogenesis;single-organism process;cytoskeleton-dependent intracellular transport;developmental process;organelle organization;multicellular organismal process;cellular process;axonogenesis;cell projection morphogenesis;system development;cell projection organization;neuron projection development;motor neuron axon guidance;multicellular organism development;cellular component morphogenesis;nitrogen compound transport;organic substance transport;RNA localization;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;response to chemical;neurogenesis;localization;single-organism localization;cellular localization;locomotion;generation of neurons;microtubule-based process;cell part morphogenesis;nervous system development;anatomical structure development;microtubule-based movement;single-organism intracellular transport; 4;4;2;5;3;4;3;4;3;3;4;6;5;5;3;6;4;1;4;3;5;5;2;7;6;6;5;6;3;2;6;2;4;2;2;7;5;4;4;5;7;4;4;5;5;4;5;6;6;3;4;3;4;3;6;2;3;3;2;7;4;5;5;3;5;5; GO:0099512;GO:0099513;GO:0005871;GO:0042995;GO:0043234;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0043228;GO:0005929;GO:0043226;GO:0005856;GO:0044430;GO:0035253;GO:0044446;GO:0044441;GO:0005874;GO:0005875;GO:0005737;GO:0043005;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0097458;GO:0015630;GO:0032991;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;kinesin complex;cell projection;protein complex;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cilium;organelle;cytoskeleton;cytoskeletal part;ciliary rootlet;intracellular organelle part;ciliary part;microtubule;microtubule associated complex;cytoplasm;neuron projection;cell projection part;cell part;cell;intracellular;neuron part;microtubule cytoskeleton;macromolecular complex;cellular_component; 2;3;5;3;3;3;2;4;3;3;3;2;5;4;4;3;3;4;4;4;4;3;2;2;3;3;6;2;1; GO:1901363;GO:0000166;GO:0008574;GO:0016818;GO:0097367;GO:0016817;GO:0005524;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:1990939;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0043167;GO:0043168; heterocyclic compound binding;nucleotide binding;ATP-dependent microtubule motor activity, plus-end-directed;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;ATP binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ATP-dependent microtubule motor activity;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;ion binding;anion binding; 3;4;9;5;3;4;6;1;2;8;4;5;5;8;9;3;2;3;3;6;6;5;6;4;5;10;6;5;4;7;3;4; K10396 map04144;map04728; Endocytosis;Dopaminergic synapse; IPR001752;IPR027417;IPR019821; Kinesin motor domain;P-loop containing nucleoside triphosphate hydrolase;Kinesin motor domain, conserved site; cytosol Hs4758650 1965.0 Z [Z] Cytoskeleton; Q9Y6R7 IgGFc-binding protein OS=Homo sapiens OX=9606 GN=FCGBP PE=1 SV=3 - [FCGBP_HUMAN] 0.857 0.9 1.53 0.958 0.812 1.719 0.952222222 0.242669964 1.179802956 0.061562252 1.7 0.012166946 2.116995074 0.001160287 GO:0043230;GO:0070062;GO:0044421;GO:0005575;GO:0005576;GO:1903561;GO:0043227;GO:0043226;GO:0031982; extracellular organelle;extracellular exosome;extracellular region part;cellular_component;extracellular region;extracellular vesicle;membrane-bounded organelle;organelle;vesicle; 3;4;2;1;2;3;3;2;4; IPR003645;IPR002919;IPR000742;IPR001007;IPR014853;IPR025615;IPR035234;IPR001846; Follistatin-like, N-terminal;Trypsin Inhibitor-like, cysteine rich domain;EGF-like domain;VWFC domain;Uncharacterised domain, cysteine-rich;TILa domain;IgGFc-binding protein, N-terminal;von Willebrand factor, type D domain; extracellular Hs4503681 10935.0 WV [W] Extracellular structures;[V] Defense mechanisms; Q96PD5 N-acetylmuramoyl-L-alanine amidase OS=Homo sapiens OX=9606 GN=PGLYRP2 PE=1 SV=1 - [PGRP2_HUMAN] 0.924 1.036 1.047 0.892 1.087 1.163 0.891891892 0.000305214 0.820607176 0.002530865 1.010617761 0.04552171 1.069917203 0.005318173 GO:0009595;GO:0048585;GO:0048584;GO:0048583;GO:0031349;GO:0007165;GO:0044707;GO:0031347;GO:0051716;GO:0043207;GO:0048869;GO:0009617;GO:0009611;GO:0044419;GO:0048513;GO:0048518;GO:0065007;GO:0030101;GO:0098581;GO:0002698;GO:0050830;GO:0046649;GO:1901564;GO:0051707;GO:1903707;GO:0001519;GO:0051704;GO:0044700;GO:0009607;GO:1901565;GO:0009605;GO:0002376;GO:0051250;GO:0030203;GO:0032824;GO:0032827;GO:0032826;GO:0032649;GO:0032823;GO:0045321;GO:0006807;GO:0042742;GO:0050789;GO:0044117;GO:0001816;GO:1901575;GO:0002764;GO:0002285;GO:0016045;GO:0002684;GO:0002366;GO:0002682;GO:0002683;GO:0032814;GO:0032815;GO:0050793;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0001779;GO:0002520;GO:0002263;GO:0002757;GO:0051606;GO:0080134;GO:0002758;GO:0001775;GO:0002695;GO:0002218;GO:0002697;GO:0006022;GO:0006518;GO:0006026;GO:0006027;GO:0006954;GO:0032101;GO:0030154;GO:0050727;GO:0044110;GO:0034641;GO:0023052;GO:0044116;GO:0009253;GO:0044699;GO:1903706;GO:0051249;GO:0051241;GO:0002521;GO:0045620;GO:1903034;GO:0002221;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0098542;GO:0098543;GO:0048519;GO:0051093;GO:0050777;GO:0050776;GO:0043603;GO:1901136;GO:1901135;GO:0050778;GO:0043170;GO:0051239;GO:0001817;GO:0045619;GO:0030098;GO:0048731;GO:0050896;GO:0001818;GO:0032609;GO:0050865;GO:0050866;GO:0007275;GO:0031179;GO:0002694;GO:0071704;GO:0048534;GO:0002325;GO:0045089;GO:0045088;GO:0045087;GO:0000270;GO:0044767;GO:0044763;GO:0007154;GO:0009056;GO:0009057;GO:0040007;GO:0048856;GO:0044237;GO:0030097;GO:1902106;GO:1902105;GO:2000026;GO:0002253;GO:0002252;GO:0032689;GO:0044403;GO:0048523;GO:0002323; detection of biotic stimulus;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;signal transduction;single-multicellular organism process;regulation of defense response;cellular response to stimulus;response to external biotic stimulus;cellular developmental process;response to bacterium;response to wounding;interspecies interaction between organisms;animal organ development;positive regulation of biological process;biological regulation;natural killer cell activation;detection of external biotic stimulus;negative regulation of immune effector process;defense response to Gram-positive bacterium;lymphocyte activation;organonitrogen compound metabolic process;response to other organism;negative regulation of hemopoiesis;peptide amidation;multi-organism process;single organism signaling;response to biotic stimulus;organonitrogen compound catabolic process;response to external stimulus;immune system process;negative regulation of lymphocyte activation;glycosaminoglycan metabolic process;negative regulation of natural killer cell differentiation;negative regulation of natural killer cell differentiation involved in immune response;regulation of natural killer cell differentiation involved in immune response;regulation of interferon-gamma production;regulation of natural killer cell differentiation;leukocyte activation;nitrogen compound metabolic process;defense response to bacterium;regulation of biological process;growth of symbiont in host;cytokine production;organic substance catabolic process;immune response-regulating signaling pathway;lymphocyte activation involved in immune response;detection of bacterium;positive regulation of immune system process;leukocyte activation involved in immune response;regulation of immune system process;negative regulation of immune system process;regulation of natural killer cell activation;negative regulation of natural killer cell activation;regulation of developmental process;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;immune response;natural killer cell differentiation;immune system development;cell activation involved in immune response;immune response-activating signal transduction;detection of stimulus;regulation of response to stress;innate immune response-activating signal transduction;cell activation;negative regulation of leukocyte activation;activation of innate immune response;regulation of immune effector process;aminoglycan metabolic process;peptide metabolic process;aminoglycan catabolic process;glycosaminoglycan catabolic process;inflammatory response;regulation of response to external stimulus;cell differentiation;regulation of inflammatory response;growth involved in symbiotic interaction;cellular nitrogen compound metabolic process;signaling;growth of symbiont involved in interaction with host;peptidoglycan catabolic process;single-organism process;regulation of hemopoiesis;regulation of lymphocyte activation;negative regulation of multicellular organismal process;leukocyte differentiation;negative regulation of lymphocyte differentiation;regulation of response to wounding;pattern recognition receptor signaling pathway;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;defense response to other organism;detection of other organism;negative regulation of biological process;negative regulation of developmental process;negative regulation of immune response;regulation of immune response;cellular amide metabolic process;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;regulation of cytokine production;regulation of lymphocyte differentiation;lymphocyte differentiation;system development;response to stimulus;negative regulation of cytokine production;interferon-gamma production;regulation of cell activation;negative regulation of cell activation;multicellular organism development;peptide modification;regulation of leukocyte activation;organic substance metabolic process;hematopoietic or lymphoid organ development;natural killer cell differentiation involved in immune response;positive regulation of innate immune response;regulation of innate immune response;innate immune response;peptidoglycan metabolic process;single-organism developmental process;single-organism cellular process;cell communication;catabolic process;macromolecule catabolic process;growth;anatomical structure development;cellular metabolic process;hemopoiesis;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;activation of immune response;immune effector process;negative regulation of interferon-gamma production;symbiosis, encompassing mutualism through parasitism;negative regulation of cellular process;natural killer cell activation involved in immune response; 4;3;3;3;4;4;3;5;3;4;4;4;4;3;4;2;2;5;5;4;6;4;4;3;4;7;2;3;3;5;3;2;5;6;7;5;5;5;7;3;3;5;2;5;4;4;5;4;5;3;4;3;3;6;6;3;3;4;3;1;2;3;6;3;4;4;3;4;5;4;4;4;4;5;5;6;7;5;4;5;5;3;4;2;4;8;2;4;5;3;6;6;5;6;2;2;2;4;4;4;4;2;3;4;4;5;5;4;4;4;3;4;6;5;4;2;4;5;4;4;4;6;4;3;4;4;5;5;4;7;3;3;4;3;5;2;3;3;5;5;5;4;3;3;5;4;3;4; GO:0031982;GO:0043230;GO:0044421;GO:0005622;GO:0043227;GO:0016020;GO:0044464;GO:0005623;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576; vesicle;extracellular organelle;extracellular region part;intracellular;membrane-bounded organelle;membrane;cell part;cell;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region; 4;3;2;3;3;2;2;2;4;2;3;1;2; GO:0042834;GO:0008745;GO:0060089;GO:0046872;GO:0097367;GO:0016810;GO:0016811;GO:0008270;GO:0003674;GO:0046914;GO:0016787;GO:0003824;GO:0043169;GO:0043167;GO:0008329;GO:0016019;GO:0005488;GO:0038023;GO:0004872;GO:0004871;GO:0005539;GO:0038187; peptidoglycan binding;N-acetylmuramoyl-L-alanine amidase activity;molecular transducer activity;metal ion binding;carbohydrate derivative binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;zinc ion binding;molecular_function;transition metal ion binding;hydrolase activity;catalytic activity;cation binding;ion binding;signaling pattern recognition receptor activity;peptidoglycan receptor activity;binding;signaling receptor activity;receptor activity;signal transducer activity;glycosaminoglycan binding;pattern recognition receptor activity; 5;6;2;5;3;4;5;7;1;6;3;2;4;3;4;5;2;3;3;2;4;4; K01446 IPR006619;IPR015510;IPR002502; Peptidoglycan recognition protein family domain, metazoa/bacteria;Peptidoglycan recognition protein;N-acetylmuramoyl-L-alanine amidase domain; extracellular 296269898 99.8 M [M] Cell wall/membrane/envelope biogenesis; COG5632 N-acetylmuramoyl-L-alanine amidase CwlA Q8N4C7 Syntaxin-19 OS=Homo sapiens OX=9606 GN=STX19 PE=1 SV=1 - [STX19_HUMAN] 1.002 0.829 1.302 0.956 1.079 0.809 1.208685163 nan 0.886005561 nan 1.570566948 nan 0.749768304 nan GO:0008104;GO:0099643;GO:0006906;GO:0061025;GO:0061024;GO:0001505;GO:0051656;GO:0051650;GO:0071840;GO:0070727;GO:0097479;GO:0033036;GO:0099504;GO:0099500;GO:0045184;GO:0048278;GO:0008150;GO:0006836;GO:0045026;GO:0097480;GO:0044700;GO:0016192;GO:0090174;GO:0016050;GO:0098916;GO:0031629;GO:0048489;GO:0006886;GO:0006887;GO:0016043;GO:0045055;GO:0065007;GO:0044699;GO:0065008;GO:0006810;GO:0099537;GO:0007268;GO:0044802;GO:0044801;GO:0051234;GO:0046903;GO:0046907;GO:0016079;GO:0099531;GO:0099536;GO:0007269;GO:0023052;GO:0051640;GO:0017156;GO:0009987;GO:0016482;GO:0032940;GO:0022406;GO:0071702;GO:0048284;GO:0034613;GO:0023061;GO:0044765;GO:0044763;GO:0051648;GO:0051649;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:1902589;GO:0015031;GO:1902582;GO:1902580; protein localization;signal release from synapse;vesicle fusion;membrane fusion;membrane organization;regulation of neurotransmitter levels;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;cellular macromolecule localization;synaptic vesicle localization;macromolecule localization;synaptic vesicle cycle;vesicle fusion to plasma membrane;establishment of protein localization;vesicle docking;biological_process;neurotransmitter transport;plasma membrane fusion;establishment of synaptic vesicle localization;single organism signaling;vesicle-mediated transport;organelle membrane fusion;vesicle organization;anterograde trans-synaptic signaling;synaptic vesicle fusion to presynaptic active zone membrane;synaptic vesicle transport;intracellular protein transport;exocytosis;cellular component organization;regulated exocytosis;biological regulation;single-organism process;regulation of biological quality;transport;trans-synaptic signaling;synaptic transmission;single-organism membrane organization;single-organism membrane fusion;establishment of localization;secretion;intracellular transport;synaptic vesicle exocytosis;presynaptic process involved in synaptic transmission;synaptic signaling;neurotransmitter secretion;signaling;organelle localization;calcium ion regulated exocytosis;cellular process;cytosolic transport;secretion by cell;membrane docking;organic substance transport;organelle fusion;cellular protein localization;signal release;single-organism transport;single-organism cellular process;vesicle localization;establishment of localization in cell;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;organelle organization;single-organism organelle organization;protein transport;single-organism intracellular transport;single-organism cellular localization; 4;6;6;5;4;4;4;5;2;4;6;3;5;6;4;5;1;5;6;6;3;5;5;5;7;3;5;6;5;3;6;2;2;3;4;6;8;4;5;3;5;5;3;2;5;3;2;4;7;2;6;4;4;5;5;5;5;4;3;5;4;4;4;2;3;3;4;4;5;5;4; GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0099503;GO:0043231;GO:0043234;GO:0044424;GO:0044425;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0044444;GO:0097708;GO:0008021;GO:0005886;GO:0031224;GO:0005737;GO:0031410;GO:0044456;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0045202;GO:0030133;GO:0031201;GO:0070382;GO:0097458;GO:0032991;GO:0005575;GO:0098796;GO:0098793; vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;secretory vesicle;intracellular membrane-bounded organelle;protein complex;intracellular part;membrane part;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;cytoplasmic part;intracellular vesicle;synaptic vesicle;plasma membrane;intrinsic component of membrane;cytoplasm;cytoplasmic vesicle;synapse part;cell part;cell;intracellular;cell periphery;synapse;transport vesicle;SNARE complex;exocytic vesicle;neuron part;macromolecular complex;cellular_component;membrane protein complex;presynapse; 4;5;4;2;5;6;4;3;3;2;3;3;2;3;4;4;3;3;3;4;5;2;2;2;3;3;2;4;4;5;3;2;1;3;3; GO:0003674;GO:0005488;GO:0005484;GO:0005515;GO:0000149; molecular_function;binding;SNAP receptor activity;protein binding;SNARE binding; 1;2;4;3;4; K08487 map04130; SNARE interactions in vesicular transport; IPR006012;IPR006011;IPR010989;IPR000727;IPR015708; Syntaxin/epimorphin, conserved site;Syntaxin, N-terminal domain;SNARE;Target SNARE coiled-coil homology domain;Syntaxin-19; cytosol Hs4507287 183.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q8N1I0 Dedicator of cytokinesis protein 4 OS=Homo sapiens OX=9606 GN=DOCK4 PE=1 SV=3 - [DOCK4_HUMAN] 0.962 0.927 1.241 1.055 0.909 1.209 1.037756203 nan 1.160616062 nan 1.338727077 nan 1.330033003 nan GO:0045906;GO:0019229;GO:0003012;GO:0003013;GO:0007165;GO:0060326;GO:0003018;GO:0045986;GO:1904694;GO:0051716;GO:0042330;GO:0044093;GO:0048518;GO:0048519;GO:0014829;GO:0006935;GO:0006936;GO:0006937;GO:0006939;GO:0003008;GO:0044700;GO:0016477;GO:0009605;GO:0044707;GO:0048870;GO:0014812;GO:0006928;GO:0045932;GO:0042310;GO:0035556;GO:0043547;GO:0051345;GO:0090066;GO:0065007;GO:0044699;GO:0065009;GO:0065008;GO:0035150;GO:0008015;GO:0050790;GO:0050794;GO:0008150;GO:1903523;GO:0051239;GO:0051336;GO:0050896;GO:2000145;GO:2000147;GO:1903522;GO:0006940;GO:0023052;GO:0070887;GO:0007154;GO:0043087;GO:0043085;GO:0003056;GO:0050880;GO:0044057;GO:0051241;GO:0032501;GO:0009987;GO:0040012;GO:0032879;GO:0051674;GO:0014911;GO:0014910;GO:0014909;GO:0050789;GO:0030335;GO:0030334;GO:0044763;GO:0090257;GO:0042221;GO:0007264;GO:0051179;GO:0040011;GO:0051272;GO:0051270;GO:0040017;GO:0048522; negative regulation of vasoconstriction;regulation of vasoconstriction;muscle system process;circulatory system process;signal transduction;cell chemotaxis;vascular process in circulatory system;negative regulation of smooth muscle contraction;negative regulation of vascular smooth muscle contraction;cellular response to stimulus;taxis;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;vascular smooth muscle contraction;chemotaxis;muscle contraction;regulation of muscle contraction;smooth muscle contraction;system process;single organism signaling;cell migration;response to external stimulus;single-multicellular organism process;cell motility;muscle cell migration;movement of cell or subcellular component;negative regulation of muscle contraction;vasoconstriction;intracellular signal transduction;positive regulation of GTPase activity;positive regulation of hydrolase activity;regulation of anatomical structure size;biological regulation;single-organism process;regulation of molecular function;regulation of biological quality;regulation of tube size;blood circulation;regulation of catalytic activity;regulation of cellular process;biological_process;negative regulation of blood circulation;regulation of multicellular organismal process;regulation of hydrolase activity;response to stimulus;regulation of cell motility;positive regulation of cell motility;regulation of blood circulation;regulation of smooth muscle contraction;signaling;cellular response to chemical stimulus;cell communication;regulation of GTPase activity;positive regulation of catalytic activity;regulation of vascular smooth muscle contraction;regulation of blood vessel size;regulation of system process;negative regulation of multicellular organismal process;multicellular organismal process;cellular process;regulation of locomotion;regulation of localization;localization of cell;positive regulation of smooth muscle cell migration;regulation of smooth muscle cell migration;smooth muscle cell migration;regulation of biological process;positive regulation of cell migration;regulation of cell migration;single-organism cellular process;regulation of muscle system process;response to chemical;small GTPase mediated signal transduction;localization;locomotion;positive regulation of cellular component movement;regulation of cellular component movement;positive regulation of locomotion;positive regulation of cellular process; 5;6;4;4;4;5;5;5;6;3;3;4;2;2;7;4;5;6;6;3;3;4;3;3;3;5;4;4;7;5;7;6;4;2;2;3;3;5;5;4;3;1;4;3;5;2;4;4;5;7;2;4;4;6;5;7;6;4;3;2;2;3;3;3;6;6;6;2;5;5;3;5;3;6;2;2;4;4;3;3; GO:0016020;GO:0098862;GO:0032420;GO:0042995;GO:0005829;GO:0098858;GO:0044424;GO:0044422;GO:0043226;GO:0071944;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0032421;GO:0097458;GO:0005886;GO:0005575; membrane;cluster of actin-based cell projections;stereocilium;cell projection;cytosol;actin-based cell projection;intracellular part;organelle part;organelle;cell periphery;cytoplasmic part;cytoplasm;cell part;cell;intracellular;stereocilium bundle;neuron part;plasma membrane;cellular_component; 2;3;3;3;5;4;3;2;2;3;4;4;2;2;3;4;3;3;1; GO:0031267;GO:0098772;GO:0005096;GO:0019901;GO:0030695;GO:0030165;GO:0019904;GO:0005085;GO:0051020;GO:0003674;GO:0005488;GO:0030971;GO:0017016;GO:0019899;GO:0060589;GO:0005515;GO:0005102;GO:0017048;GO:0008047;GO:0048365;GO:1990782;GO:0030234;GO:0019900; small GTPase binding;molecular function regulator;GTPase activator activity;protein kinase binding;GTPase regulator activity;PDZ domain binding;protein domain specific binding;guanyl-nucleotide exchange factor activity;GTPase binding;molecular_function;binding;receptor tyrosine kinase binding;Ras GTPase binding;enzyme binding;nucleoside-triphosphatase regulator activity;protein binding;receptor binding;Rho GTPase binding;enzyme activator activity;Rac GTPase binding;protein tyrosine kinase binding;enzyme regulator activity;kinase binding; 6;2;5;6;5;5;4;3;5;1;2;5;7;4;4;3;4;8;4;9;7;3;5; K17697 map04015; Rap1 signaling pathway; IPR026791;IPR027357;IPR032376;IPR001452;IPR011511;IPR027007;IPR010703;IPR026800; Dedicator of cytokinesis;DHR-2 domain;Dedicator of cytokinesis, N-terminal domain;SH3 domain;Variant SH3 domain;DHR-1 domain;Dedicator of cytokinesis, C-terminal;Dedicator of cytokinesis 3/4; cytosol Hs7662264 1523.0 T [T] Signal transduction mechanisms; Q9UGI0 Ubiquitin thioesterase ZRANB1 OS=Homo sapiens OX=9606 GN=ZRANB1 PE=1 SV=2 - [ZRAN1_HUMAN] 0.872 1.177 0.769 1.185 1.418 0.485 0.74086661 0.028747604 0.835684062 0.142193183 0.65335599 0.111458822 0.34203103 0.013136749 GO:0048584;GO:0048583;GO:0030111;GO:0007165;GO:0007166;GO:0032989;GO:0071840;GO:0051716;GO:0009966;GO:0009967;GO:0070647;GO:0070646;GO:0048518;GO:0070536;GO:0030163;GO:0044700;GO:0019538;GO:0016055;GO:0022604;GO:0022603;GO:0006928;GO:0051674;GO:0051179;GO:0044267;GO:1901575;GO:0044265;GO:0000902;GO:0044260;GO:0016043;GO:0065007;GO:1990168;GO:0016477;GO:0016579;GO:0050793;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051603;GO:0050896;GO:0006511;GO:0048869;GO:0051128;GO:0023056;GO:0023052;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0009653;GO:0006508;GO:0032502;GO:0040011;GO:0009987;GO:0019941;GO:0035523;GO:0044257;GO:0030177;GO:0043170;GO:0048870;GO:0071947;GO:0043632;GO:0050789;GO:0071704;GO:0006464;GO:0044767;GO:0044763;GO:0007154;GO:0009056;GO:0009057;GO:0044248;GO:0006996;GO:0044238;GO:0007010;GO:0048856;GO:0044237;GO:0048522; positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;regulation of signal transduction;positive regulation of signal transduction;protein modification by small protein conjugation or removal;protein modification by small protein removal;positive regulation of biological process;protein K63-linked deubiquitination;protein catabolic process;single organism signaling;protein metabolic process;Wnt signaling pathway;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;localization;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;biological regulation;protein K33-linked deubiquitination;cell migration;protein deubiquitination;regulation of developmental process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;proteolysis involved in cellular protein catabolic process;response to stimulus;ubiquitin-dependent protein catabolic process;cellular developmental process;regulation of cellular component organization;positive regulation of signaling;signaling;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;anatomical structure morphogenesis;proteolysis;developmental process;locomotion;cellular process;modification-dependent protein catabolic process;protein K29-linked deubiquitination;cellular protein catabolic process;positive regulation of Wnt signaling pathway;macromolecule metabolic process;cell motility;protein deubiquitination involved in ubiquitin-dependent protein catabolic process;modification-dependent macromolecule catabolic process;regulation of biological process;organic substance metabolic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell communication;catabolic process;macromolecule catabolic process;cellular catabolic process;organelle organization;primary metabolic process;cytoskeleton organization;anatomical structure development;cellular metabolic process;positive regulation of cellular process; 3;3;5;4;5;4;2;3;4;4;7;6;2;8;5;3;4;6;5;4;4;3;2;5;4;5;5;4;3;2;8;4;7;3;3;5;5;1;2;6;2;8;4;4;3;2;3;4;4;2;3;5;2;2;2;7;8;6;5;4;3;7;6;2;3;6;3;3;4;3;5;4;4;3;5;3;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;3;2;5;3;4;5;2;2;1;4; GO:0031593;GO:0070530;GO:0046872;GO:0043130;GO:0008270;GO:0032182;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0036459;GO:0101005;GO:0008234;GO:0043169;GO:0019783;GO:0043167;GO:0005515;GO:0008233;GO:0046914;GO:0004843;GO:0070011; polyubiquitin binding;K63-linked polyubiquitin binding;metal ion binding;ubiquitin binding;zinc ion binding;ubiquitin-like protein binding;molecular_function;binding;hydrolase activity;catalytic activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitinyl hydrolase activity;cysteine-type peptidase activity;cation binding;ubiquitin-like protein-specific protease activity;ion binding;protein binding;peptidase activity;transition metal ion binding;thiol-dependent ubiquitin-specific protease activity;peptidase activity, acting on L-amino acid peptides; 6;7;5;5;7;4;1;2;3;2;5;4;6;4;7;3;3;4;6;6;5; K11862 IPR001876;IPR003323; Zinc finger, RanBP2-type;OTU domain; cytosol Hs14747450 1473.0 T [T] Signal transduction mechanisms; Q86V25 Tubulinyl-Tyr carboxypeptidase 2 OS=Homo sapiens OX=9606 GN=VASH2 PE=1 SV=2 - [VASH2_HUMAN] 0.784 0.584 1.474 0.855 0.541 3.888 1.342465753 nan 1.580406654 nan 2.523972603 nan 7.186691312 nan GO:0008284;GO:0022603;GO:1901342;GO:0072358;GO:0050673;GO:0050789;GO:0044699;GO:0001525;GO:0009653;GO:0001568;GO:0001944;GO:0045765;GO:0045766;GO:0007275;GO:0065007;GO:0048518;GO:0048514;GO:0048646;GO:0042127;GO:0032501;GO:0008283;GO:0050793;GO:0009987;GO:0050794;GO:0044767;GO:1904018;GO:0008150;GO:0051239;GO:0032502;GO:0050678;GO:0050679;GO:0044707;GO:0051094;GO:0048856;GO:0072359;GO:0001938;GO:2000026;GO:0048731;GO:0001936;GO:0001935;GO:0051240;GO:0048522; positive regulation of cell proliferation;regulation of anatomical structure morphogenesis;regulation of vasculature development;cardiovascular system development;epithelial cell proliferation;regulation of biological process;single-organism process;angiogenesis;anatomical structure morphogenesis;blood vessel development;vasculature development;regulation of angiogenesis;positive regulation of angiogenesis;multicellular organism development;biological regulation;positive regulation of biological process;blood vessel morphogenesis;anatomical structure formation involved in morphogenesis;regulation of cell proliferation;multicellular organismal process;cell proliferation;regulation of developmental process;cellular process;regulation of cellular process;single-organism developmental process;positive regulation of vasculature development;biological_process;regulation of multicellular organismal process;developmental process;regulation of epithelial cell proliferation;positive regulation of epithelial cell proliferation;single-multicellular organism process;positive regulation of developmental process;anatomical structure development;circulatory system development;positive regulation of endothelial cell proliferation;regulation of multicellular organismal development;system development;regulation of endothelial cell proliferation;endothelial cell proliferation;positive regulation of multicellular organismal process;positive regulation of cellular process; 4;4;5;5;4;2;2;4;3;4;5;5;5;4;2;2;4;3;4;2;3;3;2;3;3;4;1;3;2;5;5;3;3;3;5;6;4;4;6;5;3;3; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part; 4;2;2;3;1;2;3; K23355 IPR028131; Vasohibin; nucleus Q9H9J4 Ubiquitin carboxyl-terminal hydrolase 42 OS=Homo sapiens OX=9606 GN=USP42 PE=1 SV=3 - [UBP42_HUMAN] 0.562 0.787 2.042 0.779 0.864 0.742 0.714104193 nan 0.90162037 nan 2.594663278 nan 0.858796296 nan GO:0030154;GO:0019953;GO:0044248;GO:0044699;GO:0044267;GO:1901575;GO:0044265;GO:0000003;GO:0044260;GO:0048869;GO:0070647;GO:0070646;GO:0071704;GO:0006511;GO:0007276;GO:0009057;GO:0006508;GO:0016579;GO:0043632;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0051603;GO:0009987;GO:0019941;GO:0006464;GO:0044767;GO:0022414;GO:0007283;GO:0036211;GO:0008150;GO:0030163;GO:0008152;GO:0048232;GO:0044257;GO:0009056;GO:0051704;GO:0044238;GO:0044703;GO:0044702;GO:0019538;GO:0043412;GO:0044237;GO:0043170;GO:0044763; cell differentiation;sexual reproduction;cellular catabolic process;single-organism process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;reproduction;cellular macromolecule metabolic process;cellular developmental process;protein modification by small protein conjugation or removal;protein modification by small protein removal;organic substance metabolic process;ubiquitin-dependent protein catabolic process;gamete generation;macromolecule catabolic process;proteolysis;protein deubiquitination;modification-dependent macromolecule catabolic process;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;cellular protein modification process;single-organism developmental process;reproductive process;spermatogenesis;protein modification process;biological_process;protein catabolic process;metabolic process;male gamete generation;cellular protein catabolic process;catabolic process;multi-organism process;primary metabolic process;multi-organism reproductive process;single organism reproductive process;protein metabolic process;macromolecule modification;cellular metabolic process;macromolecule metabolic process;single-organism cellular process; 5;3;4;2;5;4;5;2;4;4;7;6;3;8;4;5;5;7;6;2;2;3;3;6;2;7;6;3;2;6;5;1;5;2;5;6;3;2;3;3;3;4;5;3;4;3; GO:0003674;GO:0101005;GO:0008233;GO:0008234;GO:0019783;GO:0004843;GO:0016787;GO:0036459;GO:0003824;GO:0070011; molecular_function;ubiquitinyl hydrolase activity;peptidase activity;cysteine-type peptidase activity;ubiquitin-like protein-specific protease activity;thiol-dependent ubiquitin-specific protease activity;hydrolase activity;thiol-dependent ubiquitinyl hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides; 1;4;4;6;7;6;3;5;2;5; K11855 IPR018200;IPR001394;IPR028889; Ubiquitin specific protease, conserved site;Peptidase C19, ubiquitin carboxyl-terminal hydrolase;Ubiquitin specific protease domain; nucleus Hs20540195 1576.0 O [O] Posttranslational modification, protein turnover, chaperones; Q8N6S4 Ankyrin repeat domain-containing protein 13C OS=Homo sapiens OX=9606 GN=ANKRD13C PE=2 SV=2 - [AN13C_HUMAN] 0.918 1.149 0.762 1.328 1.018 1.496 0.798955614 nan 1.304518664 nan 0.663185379 nan 1.469548134 nan GO:0008104;GO:0019222;GO:0032800;GO:0035437;GO:0031323;GO:2000209;GO:0010869;GO:0043170;GO:0044237;GO:0051220;GO:0008219;GO:0010941;GO:0051651;GO:0044699;GO:1901576;GO:0070972;GO:0044260;GO:0070727;GO:0042981;GO:0050789;GO:0060255;GO:0043067;GO:0065007;GO:0033036;GO:0034613;GO:0032507;GO:0072595;GO:0009987;GO:0009889;GO:0006621;GO:0050794;GO:0045185;GO:0009058;GO:0009059;GO:0008150;GO:0043276;GO:0051235;GO:0008152;GO:0051179;GO:1902578;GO:0051641;GO:0071704;GO:0065008;GO:0012501;GO:0033365;GO:0010556;GO:0044763;GO:0043112;GO:0006915; protein localization;regulation of metabolic process;receptor biosynthetic process;maintenance of protein localization in endoplasmic reticulum;regulation of cellular metabolic process;regulation of anoikis;regulation of receptor biosynthetic process;macromolecule metabolic process;cellular metabolic process;cytoplasmic sequestering of protein;cell death;regulation of cell death;maintenance of location in cell;single-organism process;organic substance biosynthetic process;protein localization to endoplasmic reticulum;cellular macromolecule metabolic process;cellular macromolecule localization;regulation of apoptotic process;regulation of biological process;regulation of macromolecule metabolic process;regulation of programmed cell death;biological regulation;macromolecule localization;cellular protein localization;maintenance of protein location in cell;maintenance of protein localization in organelle;cellular process;regulation of biosynthetic process;protein retention in ER lumen;regulation of cellular process;maintenance of protein location;biosynthetic process;macromolecule biosynthetic process;biological_process;anoikis;maintenance of location;metabolic process;localization;single-organism localization;cellular localization;organic substance metabolic process;regulation of biological quality;programmed cell death;protein localization to organelle;regulation of macromolecule biosynthetic process;single-organism cellular process;receptor metabolic process;apoptotic process; 4;3;6;7;4;7;5;4;3;6;4;4;4;2;4;7;4;4;6;2;4;5;2;3;5;5;6;2;4;8;3;4;3;5;1;7;3;2;2;3;3;3;3;5;6;5;3;5;6; GO:0005783;GO:0043229;GO:0043226;GO:0005737;GO:0031090;GO:0043227;GO:0016020;GO:0048471;GO:0044446;GO:0098588;GO:0012505;GO:0044425;GO:0042175;GO:0044432;GO:0005789;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044422;GO:0044424; endoplasmic reticulum;intracellular organelle;organelle;cytoplasm;organelle membrane;membrane-bounded organelle;membrane;perinuclear region of cytoplasm;intracellular organelle part;bounding membrane of organelle;endomembrane system;membrane part;nuclear outer membrane-endoplasmic reticulum membrane network;endoplasmic reticulum part;endoplasmic reticulum membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;organelle part;intracellular part; 4;3;2;4;3;3;2;5;3;4;3;2;3;4;3;4;2;2;3;1;4;2;3; GO:0003674;GO:0005515;GO:0005102;GO:0005488; molecular_function;protein binding;receptor binding;binding; 1;3;4;2; K21437 IPR021832;IPR002110;IPR020683; Ankyrin repeat domain-containing protein 13;Ankyrin repeat;Ankyrin repeat-containing domain; nucleus Hs13540610 994.0 R [R] General function prediction only; Q99250 Sodium channel protein type 2 subunit alpha OS=Homo sapiens OX=9606 GN=SCN2A PE=1 SV=3 - [SCN2A_HUMAN] 0.953 1.184 0.85 0.981 1.303 0.863 0.804898649 nan 0.752877974 nan 0.717905405 nan 0.662317728 nan GO:0019226;GO:0019228;GO:0051899;GO:0007165;GO:0001508;GO:0051716;GO:0098662;GO:0008366;GO:0003008;GO:0044700;GO:0071214;GO:0044707;GO:0033554;GO:0042391;GO:0035556;GO:0050789;GO:0042552;GO:0070997;GO:0065007;GO:0044699;GO:0098660;GO:0065008;GO:0006812;GO:0006811;GO:0006810;GO:0050794;GO:0012501;GO:0006950;GO:0008150;GO:0048731;GO:0006814;GO:0050896;GO:0051402;GO:0035637;GO:0023052;GO:0008627;GO:0051234;GO:0071470;GO:0015672;GO:0032502;GO:0032501;GO:0009987;GO:0006970;GO:0086010;GO:0055085;GO:0097190;GO:0097193;GO:0007272;GO:0008219;GO:0007275;GO:0035725;GO:0050877;GO:0006915;GO:0044767;GO:0034220;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0009628;GO:0007399;GO:0048856;GO:0030001;GO:0098655; transmission of nerve impulse;neuronal action potential;membrane depolarization;signal transduction;action potential;cellular response to stimulus;inorganic cation transmembrane transport;axon ensheathment;system process;single organism signaling;cellular response to abiotic stimulus;single-multicellular organism process;cellular response to stress;regulation of membrane potential;intracellular signal transduction;regulation of biological process;myelination;neuron death;biological regulation;single-organism process;inorganic ion transmembrane transport;regulation of biological quality;cation transport;ion transport;transport;regulation of cellular process;programmed cell death;response to stress;biological_process;system development;sodium ion transport;response to stimulus;neuron apoptotic process;multicellular organismal signaling;signaling;intrinsic apoptotic signaling pathway in response to osmotic stress;establishment of localization;cellular response to osmotic stress;monovalent inorganic cation transport;developmental process;multicellular organismal process;cellular process;response to osmotic stress;membrane depolarization during action potential;transmembrane transport;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;ensheathment of neurons;cell death;multicellular organism development;sodium ion transmembrane transport;neurological system process;apoptotic process;single-organism developmental process;ion transmembrane transport;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;response to abiotic stimulus;nervous system development;anatomical structure development;metal ion transport;cation transmembrane transport; 5;6;5;4;5;3;7;5;3;3;4;3;4;4;5;2;6;5;2;2;6;3;6;5;4;3;5;3;1;4;8;2;6;4;2;6;3;5;7;2;2;2;4;6;4;5;6;4;4;4;8;4;6;3;5;4;3;4;2;3;3;5;3;7;6; GO:0030424;GO:0030054;GO:0016021;GO:0016020;GO:0001518;GO:1902495;GO:0044291;GO:0042995;GO:0043234;GO:0044425;GO:0034706;GO:0034703;GO:0042383;GO:1990351;GO:0098797;GO:0033268;GO:0005887;GO:0031226;GO:0031224;GO:0033267;GO:0043005;GO:0033270;GO:0044459;GO:0030315;GO:0005911;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0034702;GO:0014704;GO:0071944;GO:0044304;GO:0097458;GO:0005886;GO:0032991;GO:0005575;GO:0098796; axon;cell junction;integral component of membrane;membrane;voltage-gated sodium channel complex;transmembrane transporter complex;cell-cell contact zone;cell projection;protein complex;membrane part;sodium channel complex;cation channel complex;sarcolemma;transporter complex;plasma membrane protein complex;node of Ranvier;integral component of plasma membrane;intrinsic component of plasma membrane;intrinsic component of membrane;axon part;neuron projection;paranode region of axon;plasma membrane part;T-tubule;cell-cell junction;cell projection part;cell part;cell;intracellular;ion channel complex;intercalated disc;cell periphery;main axon;neuron part;plasma membrane;macromolecular complex;cellular_component;membrane protein complex; 5;2;4;2;5;4;4;3;3;2;7;6;4;4;4;5;4;4;3;4;4;5;3;4;3;3;2;2;3;5;5;3;5;3;3;2;1;3; GO:0005261;GO:0015081;GO:0046873;GO:0003674;GO:0022803;GO:0022891;GO:0022890;GO:0022892;GO:0015075;GO:0015077;GO:0015267;GO:0005248;GO:0005244;GO:0005215;GO:0005216;GO:0022832;GO:0022836;GO:0022838;GO:0008324;GO:0005272;GO:1905030;GO:0022857; cation channel activity;sodium ion transmembrane transporter activity;metal ion transmembrane transporter activity;molecular_function;passive transmembrane transporter activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;monovalent inorganic cation transmembrane transporter activity;channel activity;voltage-gated sodium channel activity;voltage-gated ion channel activity;transporter activity;ion channel activity;voltage-gated channel activity;gated channel activity;substrate-specific channel activity;cation transmembrane transporter activity;sodium channel activity;voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential;transmembrane transporter activity; 7;9;8;1;4;4;7;3;5;8;5;9;7;2;6;7;6;5;6;8;8;3; K04834 map04742; Taste transduction; IPR010526;IPR024583;IPR005821;IPR000048;IPR001696; Sodium ion transport-associated;Voltage-gated Na+ ion channel, cytoplasmic domain;Ion transport domain;IQ motif, EF-hand binding site;Voltage gated sodium channel, alpha subunit; plasma membrane Hs10337597 4134.0 PT [P] Inorganic ion transport and metabolism;[T] Signal transduction mechanisms; Q6ZN84 Coiled-coil domain-containing protein 81 OS=Homo sapiens OX=9606 GN=CCDC81 PE=2 SV=2 - [CCD81_HUMAN] 0.993 0.964 1.149 0.997 1.144 0.695 1.030082988 nan 0.871503497 nan 1.191908714 nan 0.607517483 nan GO:0005737;GO:0005856;GO:0015630;GO:0043232;GO:0005813;GO:0044464;GO:0044446;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0043228;GO:0044430;GO:0044424;GO:0005815;GO:0043226;GO:0044422; cytoplasm;cytoskeleton;microtubule cytoskeleton;intracellular non-membrane-bounded organelle;centrosome;cell part;intracellular organelle part;cell;intracellular;cellular_component;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;intracellular part;microtubule organizing center;organelle;organelle part; 4;5;6;4;5;2;3;2;3;1;3;3;4;3;5;2;2; IPR010992;IPR028034;IPR026295; Integration host factor (IHF)-like DNA-binding domain;Domain of unknown function DUF4496;Coiled-coil domain-containing protein 81; cytosol Q8TD26 Chromodomain-helicase-DNA-binding protein 6 OS=Homo sapiens OX=9606 GN=CHD6 PE=1 SV=4 - [CHD6_HUMAN] 1.178 1.078 0.851 1.077 1.028 1.056 1.092764378 0.165628035 1.04766537 0.060274841 0.789424861 0.422682424 1.027237354 0.238660463 GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0036003;GO:0051716;GO:0010604;GO:0048518;GO:0060255;GO:0006366;GO:2001141;GO:0046483;GO:0033554;GO:0019438;GO:0070887;GO:0009891;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0018130;GO:1901522;GO:0009889;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0010557;GO:0006357;GO:0016568;GO:0036091;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0043619;GO:0009893;GO:0006139;GO:0043618;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0006979;GO:0051252;GO:0051254;GO:1902680;GO:0010628;GO:0045944;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0006355;GO:0006325;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0006351;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0042221;GO:0034599;GO:0043620;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of transcription from RNA polymerase II promoter in response to stress;cellular response to stimulus;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of RNA biosynthetic process;heterocycle metabolic process;cellular response to stress;aromatic compound biosynthetic process;cellular response to chemical stimulus;positive regulation of biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;heterocycle biosynthetic process;positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;regulation of biosynthetic process;regulation of cellular process;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;chromatin modification;positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;positive regulation of metabolic process;nucleobase-containing compound metabolic process;regulation of transcription from RNA polymerase II promoter in response to stress;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;response to oxidative stress;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of transcription, DNA-templated;chromatin organization;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;transcription, DNA-templated;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;cellular response to oxidative stress;regulation of DNA-templated transcription in response to stress;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;7;3;4;2;4;7;6;4;4;5;4;4;3;4;7;4;4;3;2;2;5;5;4;3;3;1;2;5;5;5;2;5;7;6;6;6;4;4;5;6;3;4;6;7;2;4;7;6;4;5;5;6;5;7;5;4;5;4;4;5;6;5;6;2;3;5;5;5;6;5;5;3;5;4;4;3;5;5;4;3;5;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;2;5;3;5;2;2;3;1;4; GO:1901363;GO:0000166;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0008094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008026;GO:0035639;GO:0043168;GO:0043167;GO:0008134;GO:0001221;GO:0030554;GO:0005515;GO:0016887;GO:0001883;GO:0001882;GO:1901265;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;molecular_function;binding;nucleic acid binding;DNA binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;DNA-dependent ATPase activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;anion binding;ion binding;transcription factor binding;transcription cofactor binding;adenyl nucleotide binding;protein binding;ATPase activity;purine nucleoside binding;nucleoside binding;nucleoside phosphate binding;nucleoside-triphosphatase activity;small molecule binding; 3;4;8;5;3;4;9;1;2;4;5;9;5;5;6;3;2;10;3;6;6;5;6;4;10;5;4;3;4;5;6;3;8;5;4;4;7;3; K14436 IPR000330;IPR023780;IPR006576;IPR001650;IPR002464;IPR014001;IPR016197;IPR000953;IPR027417; SNF2-related, N-terminal domain;Chromo domain;BRK domain;Helicase, C-terminal;DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;Helicase superfamily 1/2, ATP-binding domain;Chromo domain-like;Chromo/chromo shadow domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs21362042 5631.0 K [K] Transcription; P31276 Homeobox protein Hox-C13 OS=Homo sapiens OX=9606 GN=HOXC13 PE=1 SV=3 - [HXC13_HUMAN] 0.708 0.732 2.057 0.895 0.657 0.687 0.967213115 0.701803928 1.362252664 0.051288229 2.81010929 0.003636006 1.0456621 0.717630708 GO:0060173;GO:0098773;GO:0009653;GO:0007275;GO:0044699;GO:0008544;GO:0035878;GO:0022404;GO:0043586;GO:0043587;GO:0048513;GO:0090596;GO:0032502;GO:0009887;GO:0032501;GO:0007389;GO:0060429;GO:0009888;GO:0044767;GO:0008150;GO:0003002;GO:0042633;GO:0042303;GO:0007423;GO:0009952;GO:0044707;GO:0048856;GO:0022405;GO:0043588;GO:0048731;GO:0001942;GO:0048736; limb development;skin epidermis development;anatomical structure morphogenesis;multicellular organism development;single-organism process;epidermis development;nail development;molting cycle process;tongue development;tongue morphogenesis;animal organ development;sensory organ morphogenesis;developmental process;organ morphogenesis;multicellular organismal process;pattern specification process;epithelium development;tissue development;single-organism developmental process;biological_process;regionalization;hair cycle;molting cycle;sensory organ development;anterior/posterior pattern specification;single-multicellular organism process;anatomical structure development;hair cycle process;skin development;system development;hair follicle development;appendage development; 5;6;3;4;2;6;4;4;5;6;4;5;2;4;2;4;5;4;3;1;5;5;4;4;6;3;3;5;5;4;4;4; GO:0043226;GO:0043229;GO:0043227;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; organelle;intracellular organelle;membrane-bounded organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 2;3;3;5;4;2;2;3;1;3; GO:0001077;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043565;GO:1901363;GO:0000982;GO:0000981;GO:0003700;GO:0097159;GO:0001228;GO:0044877;GO:0003682;GO:0001071; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;molecular_function;binding;nucleic acid binding;DNA binding;sequence-specific DNA binding;heterocyclic compound binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;macromolecular complex binding;chromatin binding;nucleic acid binding transcription factor activity; 6;1;2;4;5;6;3;5;4;3;3;5;3;4;2; K09298 IPR009057;IPR017970;IPR001356;IPR022067; Homeobox domain-like;Homeobox, conserved site;Homeobox domain;Homeobox protein Hox1A3 N-terminal; nucleus Hs13651012 672.0 K [K] Transcription; P25705 ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1 - [ATPA_HUMAN] 0.852 1.047 1.501 0.977 0.814 0.49 0.813753582 0.408586392 1.2002457 0.092723743 1.433619866 0.17251104 0.601965602 0.392778071 GO:0046129;GO:0051234;GO:0050794;GO:0050680;GO:0009167;GO:0009165;GO:0044281;GO:0009161;GO:1901362;GO:0009168;GO:0044710;GO:0044711;GO:1990542;GO:1902600;GO:0009199;GO:0022900;GO:0042455;GO:0022904;GO:0048519;GO:0042127;GO:0009206;GO:0009205;GO:0009201;GO:0046034;GO:0098660;GO:0006839;GO:1901564;GO:0042451;GO:0046128;GO:0055114;GO:0046483;GO:0044707;GO:0006163;GO:0006164;GO:0009163;GO:0009259;GO:0009142;GO:0009144;GO:0009145;GO:0050789;GO:0006807;GO:0050673;GO:0015992;GO:0009127;GO:0065007;GO:0098662;GO:0090662;GO:0018130;GO:0006818;GO:0006629;GO:0009156;GO:0006811;GO:0006810;GO:0009152;GO:0045333;GO:0008152;GO:0019438;GO:0034654;GO:0009150;GO:0090407;GO:0044271;GO:0015980;GO:0046907;GO:0009260;GO:0046390;GO:0044765;GO:1901293;GO:0008150;GO:0006753;GO:0006754;GO:0051649;GO:0009117;GO:0009790;GO:0034641;GO:0009123;GO:0009126;GO:1901566;GO:0044699;GO:0006139;GO:0042278;GO:1902578;GO:0009141;GO:0015672;GO:0072522;GO:0032502;GO:0015985;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:0055086;GO:0015986;GO:1901659;GO:0055085;GO:0006812;GO:0050678;GO:1901137;GO:1901135;GO:0009124;GO:0008285;GO:0015988;GO:0019693;GO:0072521;GO:0006091;GO:0007275;GO:0019637;GO:1901360;GO:0006796;GO:0071704;GO:1901657;GO:0015991;GO:1901576;GO:0044767;GO:0034220;GO:0009058;GO:0044763;GO:0009116;GO:0042776;GO:0009119;GO:0051179;GO:0051641;GO:0044238;GO:0001936;GO:0001935;GO:0048856;GO:0044237;GO:0001937;GO:0006793;GO:1902582;GO:0098655;GO:0044249;GO:0048523; purine ribonucleoside biosynthetic process;establishment of localization;regulation of cellular process;negative regulation of epithelial cell proliferation;purine ribonucleoside monophosphate metabolic process;nucleotide biosynthetic process;small molecule metabolic process;ribonucleoside monophosphate metabolic process;organic cyclic compound biosynthetic process;purine ribonucleoside monophosphate biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;mitochondrial transmembrane transport;hydrogen ion transmembrane transport;ribonucleoside triphosphate metabolic process;electron transport chain;ribonucleoside biosynthetic process;respiratory electron transport chain;negative regulation of biological process;regulation of cell proliferation;purine ribonucleoside triphosphate biosynthetic process;purine ribonucleoside triphosphate metabolic process;ribonucleoside triphosphate biosynthetic process;ATP metabolic process;inorganic ion transmembrane transport;mitochondrial transport;organonitrogen compound metabolic process;purine nucleoside biosynthetic process;purine ribonucleoside metabolic process;oxidation-reduction process;heterocycle metabolic process;single-multicellular organism process;purine nucleotide metabolic process;purine nucleotide biosynthetic process;nucleoside biosynthetic process;ribonucleotide metabolic process;nucleoside triphosphate biosynthetic process;purine nucleoside triphosphate metabolic process;purine nucleoside triphosphate biosynthetic process;regulation of biological process;nitrogen compound metabolic process;epithelial cell proliferation;proton transport;purine nucleoside monophosphate biosynthetic process;biological regulation;inorganic cation transmembrane transport;ATP hydrolysis coupled transmembrane transport;heterocycle biosynthetic process;hydrogen transport;lipid metabolic process;ribonucleoside monophosphate biosynthetic process;ion transport;transport;purine ribonucleotide biosynthetic process;cellular respiration;metabolic process;aromatic compound biosynthetic process;nucleobase-containing compound biosynthetic process;purine ribonucleotide metabolic process;organophosphate biosynthetic process;cellular nitrogen compound biosynthetic process;energy derivation by oxidation of organic compounds;intracellular transport;ribonucleotide biosynthetic process;ribose phosphate biosynthetic process;single-organism transport;nucleoside phosphate biosynthetic process;biological_process;nucleoside phosphate metabolic process;ATP biosynthetic process;establishment of localization in cell;nucleotide metabolic process;embryo development;cellular nitrogen compound metabolic process;nucleoside monophosphate metabolic process;purine nucleoside monophosphate metabolic process;organonitrogen compound biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;purine nucleoside metabolic process;single-organism localization;nucleoside triphosphate metabolic process;monovalent inorganic cation transport;purine-containing compound biosynthetic process;developmental process;energy coupled proton transport, down electrochemical gradient;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;nucleobase-containing small molecule metabolic process;ATP synthesis coupled proton transport;glycosyl compound biosynthetic process;transmembrane transport;cation transport;regulation of epithelial cell proliferation;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;nucleoside monophosphate biosynthetic process;negative regulation of cell proliferation;energy coupled proton transmembrane transport, against electrochemical gradient;ribose phosphate metabolic process;purine-containing compound metabolic process;generation of precursor metabolites and energy;multicellular organism development;organophosphate metabolic process;organic cyclic compound metabolic process;phosphate-containing compound metabolic process;organic substance metabolic process;glycosyl compound metabolic process;ATP hydrolysis coupled proton transport;organic substance biosynthetic process;single-organism developmental process;ion transmembrane transport;biosynthetic process;single-organism cellular process;nucleoside metabolic process;mitochondrial ATP synthesis coupled proton transport;ribonucleoside metabolic process;localization;cellular localization;primary metabolic process;regulation of endothelial cell proliferation;endothelial cell proliferation;anatomical structure development;cellular metabolic process;negative regulation of endothelial cell proliferation;phosphorus metabolic process;single-organism intracellular transport;cation transmembrane transport;cellular biosynthetic process;negative regulation of cellular process; 8;3;3;5;8;6;4;7;5;8;3;4;5;7;7;4;7;5;2;4;8;8;7;8;6;6;4;7;7;4;4;3;6;7;6;6;6;7;7;2;3;4;6;7;2;7;5;5;5;4;7;5;4;8;5;2;5;5;7;5;5;4;5;7;6;4;5;1;5;9;4;6;5;4;6;7;5;2;4;6;3;6;7;6;2;8;2;3;2;4;4;9;5;4;6;5;5;4;6;4;8;5;5;4;4;4;4;5;3;4;6;4;3;5;3;3;5;6;6;2;3;3;6;5;3;3;6;4;5;6;4;3; GO:0031974;GO:0031975;GO:0045261;GO:0031982;GO:0043209;GO:0016020;GO:0031967;GO:0031966;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0044464;GO:0045259;GO:0043229;GO:0043227;GO:0043226;GO:0044421;GO:0044444;GO:0016469;GO:0005737;GO:0031090;GO:0005739;GO:0044455;GO:0019866;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0071944;GO:0033178;GO:0070062;GO:0070013;GO:0098800;GO:0005753;GO:0005759;GO:0044446;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0098796;GO:0005576;GO:0098798; membrane-enclosed lumen;envelope;proton-transporting ATP synthase complex, catalytic core F(1);vesicle;myelin sheath;membrane;organelle envelope;mitochondrial membrane;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;membrane part;organelle part;cell part;proton-transporting ATP synthase complex;intracellular organelle;membrane-bounded organelle;organelle;extracellular region part;cytoplasmic part;proton-transporting two-sector ATPase complex;cytoplasm;organelle membrane;mitochondrion;mitochondrial membrane part;organelle inner membrane;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;cell periphery;proton-transporting two-sector ATPase complex, catalytic domain;extracellular exosome;intracellular organelle lumen;inner mitochondrial membrane protein complex;mitochondrial proton-transporting ATP synthase complex;mitochondrial matrix;intracellular organelle part;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;membrane protein complex;extracellular region;mitochondrial protein complex; 2;3;4;4;3;2;4;4;3;3;4;3;4;3;2;2;2;4;3;3;2;2;4;4;4;3;5;3;4;2;3;5;5;3;4;4;4;4;5;5;3;3;3;2;1;3;2;4; GO:1901363;GO:0000166;GO:0046961;GO:0016818;GO:0097367;GO:0016817;GO:0019829;GO:0015405;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042625;GO:0042626;GO:0042623;GO:0015399;GO:0032549;GO:0017076;GO:0022804;GO:0016787;GO:0017111;GO:0003824;GO:0022891;GO:0022890;GO:0022892;GO:0097159;GO:0043492;GO:0015075;GO:0016462;GO:0032559;GO:0032555;GO:0015078;GO:0032553;GO:0035639;GO:0036442;GO:0005524;GO:0016820;GO:0046933;GO:0043167;GO:0042288;GO:0005215;GO:0044822;GO:0030554;GO:0032550;GO:0003723;GO:0005515;GO:0005102;GO:0003676;GO:0036094;GO:0001883;GO:0001882;GO:0015077;GO:0042287;GO:0008324;GO:0044769;GO:0043168;GO:0022857;GO:0022853; heterocyclic compound binding;nucleotide binding;proton-transporting ATPase activity, rotational mechanism;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;cation-transporting ATPase activity;P-P-bond-hydrolysis-driven transmembrane transporter activity;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase coupled ion transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;primary active transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;active transmembrane transporter activity;hydrolase activity;nucleoside-triphosphatase activity;catalytic activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;organic cyclic compound binding;ATPase activity, coupled to movement of substances;ion transmembrane transporter activity;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;hydrogen ion transmembrane transporter activity;ribonucleotide binding;purine ribonucleoside triphosphate binding;hydrogen-exporting ATPase activity;ATP binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;proton-transporting ATP synthase activity, rotational mechanism;ion binding;MHC class I protein binding;transporter activity;poly(A) RNA binding;adenyl nucleotide binding;purine ribonucleoside binding;RNA binding;protein binding;receptor binding;nucleic acid binding;small molecule binding;purine nucleoside binding;nucleoside binding;monovalent inorganic cation transmembrane transporter activity;MHC protein binding;cation transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of ions, rotational mechanism;anion binding;transmembrane transporter activity;active ion transmembrane transporter activity; 3;4;8;5;3;4;7;6;1;2;8;4;6;6;9;5;5;5;4;3;7;2;4;7;3;3;10;5;6;6;5;9;4;5;8;6;5;8;3;6;2;6;6;6;5;3;4;4;3;5;4;8;5;6;7;4;3;5; K02132 map00190;map01100;map05010;map05012;map05016; Oxidative phosphorylation;Metabolic pathways;Alzheimer's disease;Parkinson's disease;Huntington's disease; IPR000194;IPR005294;IPR000793;IPR033732;IPR020003;IPR004100;IPR023366;IPR027417; ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain;ATP synthase, F1 complex, alpha subunit;ATP synthase, alpha subunit, C-terminal;ATP synthase, F1 complex, alpha subunit nucleotide-binding domain;ATPase, alpha/beta subunit, nucleotide-binding domain, active site;ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain;ATP synthase subunit alpha-like domain;P-loop containing nucleoside triphosphate hydrolase; mitochondria Hs4757810 1117.0 C [C] Energy production and conversion; Q04721 Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX=9606 GN=NOTCH2 PE=1 SV=3 - [NOTC2_HUMAN] 1.028 1.369 0.746 0.855 1.436 0.284 0.750913075 nan 0.5954039 nan 0.544923302 nan 0.197771588 nan GO:0003177;GO:0048589;GO:0048584;GO:0048583;GO:0048771;GO:0072358;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0080090;GO:0051716;GO:0007219;GO:0045786;GO:0019222;GO:0009966;GO:0048869;GO:0043067;GO:0048513;GO:0048518;GO:0048519;GO:0051057;GO:0051056;GO:0006367;GO:0019827;GO:0060255;GO:0060548;GO:0006366;GO:0048731;GO:0003007;GO:0046649;GO:2001141;GO:0046483;GO:0044700;GO:0044707;GO:0019538;GO:0042246;GO:0072359;GO:0002376;GO:0046849;GO:0060411;GO:0061314;GO:0003283;GO:0045321;GO:0006807;GO:0035556;GO:0043170;GO:0050789;GO:0097659;GO:0003205;GO:1901576;GO:0009653;GO:0016049;GO:0044260;GO:0002285;GO:0003209;GO:0002366;GO:0065007;GO:0007049;GO:0044267;GO:0061311;GO:0018130;GO:0009887;GO:0006139;GO:0050793;GO:0009889;GO:0009888;GO:0042060;GO:0050794;GO:0007050;GO:0012501;GO:0001775;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:1902533;GO:1902531;GO:0002521;GO:0002520;GO:0016070;GO:0045165;GO:0044271;GO:0098727;GO:0050896;GO:0006950;GO:0006355;GO:0010556;GO:0006351;GO:0006352;GO:0009967;GO:0002263;GO:0032774;GO:0060413;GO:0030154;GO:0046578;GO:0046579;GO:0009611;GO:0023056;GO:0034641;GO:0023052;GO:0019438;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0001709;GO:0031099;GO:0032502;GO:0008285;GO:0032501;GO:0007507;GO:0009987;GO:0006725;GO:1903506;GO:0007220;GO:0003206;GO:0051252;GO:0003179;GO:0030098;GO:0030097;GO:0002335;GO:0042127;GO:0031326;GO:0031323;GO:0042113;GO:0090304;GO:0022402;GO:0008219;GO:0010941;GO:0007275;GO:0003170;GO:0030522;GO:0040007;GO:0042981;GO:0008283;GO:2000112;GO:0003184;GO:0071704;GO:0010467;GO:0043066;GO:0048534;GO:0043069;GO:0010468;GO:0030183;GO:0019219;GO:0006915;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007154;GO:0007265;GO:0007264;GO:0044238;GO:0003279;GO:0007399;GO:0051726;GO:0048856;GO:0044237;GO:0003230;GO:0048523;GO:0002252;GO:0002315;GO:0002313;GO:0044249;GO:0002312;GO:0048522; pulmonary valve development;developmental growth;positive regulation of response to stimulus;regulation of response to stimulus;tissue remodeling;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of primary metabolic process;cellular response to stimulus;Notch signaling pathway;negative regulation of cell cycle;regulation of metabolic process;regulation of signal transduction;cellular developmental process;regulation of programmed cell death;animal organ development;positive regulation of biological process;negative regulation of biological process;positive regulation of small GTPase mediated signal transduction;regulation of small GTPase mediated signal transduction;transcription initiation from RNA polymerase II promoter;stem cell population maintenance;regulation of macromolecule metabolic process;negative regulation of cell death;transcription from RNA polymerase II promoter;system development;heart morphogenesis;lymphocyte activation;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;single-multicellular organism process;protein metabolic process;tissue regeneration;circulatory system development;immune system process;bone remodeling;cardiac septum morphogenesis;Notch signaling involved in heart development;atrial septum development;leukocyte activation;nitrogen compound metabolic process;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;cardiac chamber development;organic substance biosynthetic process;anatomical structure morphogenesis;cell growth;cellular macromolecule metabolic process;lymphocyte activation involved in immune response;cardiac atrium morphogenesis;leukocyte activation involved in immune response;biological regulation;cell cycle;cellular protein metabolic process;cell surface receptor signaling pathway involved in heart development;heterocycle biosynthetic process;organ morphogenesis;nucleobase-containing compound metabolic process;regulation of developmental process;regulation of biosynthetic process;tissue development;wound healing;regulation of cellular process;cell cycle arrest;programmed cell death;cell activation;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;leukocyte differentiation;immune system development;RNA metabolic process;cell fate commitment;cellular nitrogen compound biosynthetic process;maintenance of cell number;response to stimulus;response to stress;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;positive regulation of signal transduction;cell activation involved in immune response;RNA biosynthetic process;atrial septum morphogenesis;cell differentiation;regulation of Ras protein signal transduction;positive regulation of Ras protein signal transduction;response to wounding;positive regulation of signaling;cellular nitrogen compound metabolic process;signaling;aromatic compound biosynthetic process;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;cell fate determination;regeneration;developmental process;negative regulation of cell proliferation;multicellular organismal process;heart development;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;Notch receptor processing;cardiac chamber morphogenesis;regulation of RNA metabolic process;heart valve morphogenesis;lymphocyte differentiation;hemopoiesis;mature B cell differentiation;regulation of cell proliferation;regulation of cellular biosynthetic process;regulation of cellular metabolic process;B cell activation;nucleic acid metabolic process;cell cycle process;cell death;regulation of cell death;multicellular organism development;heart valve development;intracellular receptor signaling pathway;growth;regulation of apoptotic process;cell proliferation;regulation of cellular macromolecule biosynthetic process;pulmonary valve morphogenesis;organic substance metabolic process;gene expression;negative regulation of apoptotic process;hematopoietic or lymphoid organ development;negative regulation of programmed cell death;regulation of gene expression;B cell differentiation;regulation of nucleobase-containing compound metabolic process;apoptotic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;primary metabolic process;cardiac septum development;nervous system development;regulation of cell cycle;anatomical structure development;cellular metabolic process;cardiac atrium development;negative regulation of cellular process;immune effector process;marginal zone B cell differentiation;mature B cell differentiation involved in immune response;cellular biosynthetic process;B cell activation involved in immune response;positive regulation of cellular process; 5;3;3;3;4;5;4;5;5;4;4;3;6;4;3;4;4;5;4;2;2;6;6;8;4;4;4;7;4;5;4;6;4;3;3;4;4;5;2;5;4;5;5;3;3;5;4;2;7;4;4;3;3;4;4;5;4;2;4;5;5;5;4;4;3;4;4;5;3;5;5;4;1;2;3;5;5;5;6;3;5;5;5;3;2;3;6;5;6;7;4;4;6;5;5;7;7;4;3;4;2;5;5;3;4;4;2;5;4;2;4;2;4;2;4;7;6;4;5;4;5;5;7;4;5;4;5;5;4;4;4;4;4;5;2;6;3;6;5;3;5;6;4;5;5;6;5;6;3;3;5;3;4;4;7;6;3;4;5;4;3;3;5;3;3;5;4;4;4;3; GO:0005783;GO:0031974;GO:0005789;GO:0031981;GO:0016021;GO:0016020;GO:0098588;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043235;GO:0005654;GO:0044432;GO:0044431;GO:0012505;GO:0031224;GO:0044446;GO:0044444;GO:0042175;GO:0031226;GO:0005737;GO:0031090;GO:0005634;GO:0044459;GO:0009986;GO:0000139;GO:0044464;GO:0005623;GO:0005622;GO:0005794;GO:0071944;GO:0043226;GO:0005887;GO:0005886;GO:0032991;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;membrane-enclosed lumen;endoplasmic reticulum membrane;nuclear lumen;integral component of membrane;membrane;bounding membrane of organelle;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;receptor complex;nucleoplasm;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;intrinsic component of membrane;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;intrinsic component of plasma membrane;cytoplasm;organelle membrane;nucleus;plasma membrane part;cell surface;Golgi membrane;cell part;cell;intracellular;Golgi apparatus;cell periphery;organelle;integral component of plasma membrane;plasma membrane;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 4;2;3;5;4;2;4;3;4;3;4;3;2;2;3;3;4;5;4;4;3;3;3;4;3;4;4;3;5;3;3;5;2;2;3;4;3;2;4;3;2;1;4;2; GO:0060089;GO:0001076;GO:0038049;GO:0046872;GO:0003674;GO:0005488;GO:0000989;GO:0000988;GO:0043169;GO:0043167;GO:0005509;GO:0038023;GO:0004872;GO:0004871; molecular transducer activity;transcription factor activity, RNA polymerase II transcription factor binding;transcription factor activity, ligand-activated RNA polymerase II transcription factor binding;metal ion binding;molecular_function;binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;cation binding;ion binding;calcium ion binding;signaling receptor activity;receptor activity;signal transducer activity; 2;4;4;5;1;2;3;2;4;3;6;3;3;2; K20994 IPR000152;IPR018097;IPR008297;IPR009030;IPR000800;IPR020683;IPR001881;IPR002110;IPR000742;IPR011656;IPR013032;IPR024600;IPR022336;IPR010660; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Notch;Growth factor receptor cysteine-rich domain;Notch domain;Ankyrin repeat-containing domain;EGF-like calcium-binding domain;Ankyrin repeat;EGF-like domain;Notch, NODP domain;EGF-like, conserved site;Domain of unknown function DUF3454, notch;Neurogenic locus Notch 2;Notch, NOD domain; plasma membrane Hs13249344 5048.0 T [T] Signal transduction mechanisms; Q96EE3 Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3 - [SEH1_HUMAN] 1.015 0.888 1.301 1.004 0.924 0.973 1.143018018 nan 1.086580087 nan 1.46509009 nan 1.053030303 nan GO:0008104;GO:0019221;GO:0019222;GO:0051049;GO:0034605;GO:0043412;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0034198;GO:0051656;GO:1901362;GO:0071840;GO:0032774;GO:0071705;GO:0044710;GO:0016925;GO:0010605;GO:0043207;GO:0070727;GO:0009966;GO:0009967;GO:0009617;GO:0010256;GO:0010467;GO:0018193;GO:0051315;GO:0044419;GO:0032446;GO:0016458;GO:0019058;GO:0051817;GO:0048519;GO:0033036;GO:0019054;GO:0048584;GO:0034470;GO:0060255;GO:0045184;GO:0050830;GO:0007077;GO:0051701;GO:0051707;GO:0010033;GO:0051704;GO:0031503;GO:0044700;GO:0031668;GO:0031669;GO:0009607;GO:0009605;GO:0044707;GO:0035556;GO:0019538;GO:0031667;GO:0018205;GO:0033554;GO:0019438;GO:0044281;GO:0009892;GO:0019080;GO:0044068;GO:0019083;GO:0006997;GO:0008152;GO:0006807;GO:0044033;GO:0042742;GO:0034660;GO:0002532;GO:0002534;GO:0050789;GO:0000278;GO:0044267;GO:0044260;GO:0008645;GO:0046483;GO:0016043;GO:0008643;GO:0023051;GO:0065007;GO:0007049;GO:0065008;GO:0018130;GO:0034097;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0008150;GO:0009267;GO:0009266;GO:0034654;GO:0051236;GO:1902533;GO:0051234;GO:0016070;GO:0050658;GO:0044271;GO:0071345;GO:0050896;GO:0080135;GO:0050657;GO:0009059;GO:0032008;GO:0044802;GO:0032006;GO:0015931;GO:0006954;GO:0070647;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0007154;GO:0010647;GO:0010646;GO:0044699;GO:0006139;GO:1902531;GO:0000280;GO:0051081;GO:0044003;GO:0007080;GO:0051640;GO:0007059;GO:0032501;GO:0008033;GO:0044238;GO:0043687;GO:0009987;GO:0006725;GO:0009058;GO:0048518;GO:0098542;GO:0051310;GO:0009408;GO:0051303;GO:0032879;GO:0055085;GO:0008608;GO:0030397;GO:0000819;GO:1900034;GO:0098813;GO:0010629;GO:0043170;GO:0001816;GO:0080134;GO:0009991;GO:0043933;GO:0019048;GO:1903047;GO:0090304;GO:0010827;GO:0071496;GO:0022402;GO:0006998;GO:0042594;GO:0034629;GO:0051028;GO:0051301;GO:0071822;GO:1901360;GO:0015758;GO:0071704;GO:0071310;GO:0071702;GO:0006403;GO:0010468;GO:0015749;GO:0007067;GO:1901576;GO:0031929;GO:0034613;GO:0006464;GO:0044765;GO:0044764;GO:0044763;GO:0031047;GO:0051649;GO:0042221;GO:0007264;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0009628;GO:0000070;GO:0051276;GO:0005975;GO:0044237;GO:0006999;GO:0006399;GO:1902589;GO:0050000;GO:0048285;GO:0016032;GO:0015031;GO:0044403;GO:1902580;GO:0022411;GO:0035821;GO:0006396;GO:0048522; protein localization;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of transport;cellular response to heat;macromolecule modification;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;cellular response to amino acid starvation;establishment of organelle localization;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;RNA biosynthetic process;nitrogen compound transport;single-organism metabolic process;protein sumoylation;negative regulation of macromolecule metabolic process;response to external biotic stimulus;cellular macromolecule localization;regulation of signal transduction;positive regulation of signal transduction;response to bacterium;endomembrane system organization;gene expression;peptidyl-amino acid modification;attachment of mitotic spindle microtubules to kinetochore;interspecies interaction between organisms;protein modification by small protein conjugation;gene silencing;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of biological process;macromolecule localization;modulation by virus of host process;positive regulation of response to stimulus;ncRNA processing;regulation of macromolecule metabolic process;establishment of protein localization;defense response to Gram-positive bacterium;mitotic nuclear envelope disassembly;interaction with host;response to other organism;response to organic substance;multi-organism process;protein complex localization;single organism signaling;cellular response to extracellular stimulus;cellular response to nutrient levels;response to biotic stimulus;response to external stimulus;single-multicellular organism process;intracellular signal transduction;protein metabolic process;response to nutrient levels;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;small molecule metabolic process;negative regulation of metabolic process;viral gene expression;modulation by symbiont of host cellular process;viral transcription;nucleus organization;metabolic process;nitrogen compound metabolic process;multi-organism metabolic process;defense response to bacterium;ncRNA metabolic process;production of molecular mediator involved in inflammatory response;cytokine production involved in inflammatory response;regulation of biological process;mitotic cell cycle;cellular protein metabolic process;cellular macromolecule metabolic process;hexose transport;heterocycle metabolic process;cellular component organization;carbohydrate transport;regulation of signaling;biological regulation;cell cycle;regulation of biological quality;heterocycle biosynthetic process;response to cytokine;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;protein modification process;biological_process;cellular response to starvation;response to temperature stimulus;nucleobase-containing compound biosynthetic process;establishment of RNA localization;positive regulation of intracellular signal transduction;establishment of localization;RNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;nucleic acid transport;macromolecule biosynthetic process;positive regulation of TOR signaling;single-organism membrane organization;regulation of TOR signaling;nucleobase-containing compound transport;inflammatory response;protein modification by small protein conjugation or removal;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;cell communication;positive regulation of cell communication;regulation of cell communication;single-organism process;nucleobase-containing compound metabolic process;regulation of intracellular signal transduction;nuclear division;nuclear envelope disassembly;modification by symbiont of host morphology or physiology;mitotic metaphase plate congression;organelle localization;chromosome segregation;multicellular organismal process;tRNA processing;primary metabolic process;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;biosynthetic process;positive regulation of biological process;defense response to other organism;metaphase plate congression;response to heat;establishment of chromosome localization;regulation of localization;transmembrane transport;attachment of spindle microtubules to kinetochore;membrane disassembly;sister chromatid segregation;regulation of cellular response to heat;nuclear chromosome segregation;negative regulation of gene expression;macromolecule metabolic process;cytokine production;regulation of response to stress;response to extracellular stimulus;macromolecular complex subunit organization;modulation by virus of host morphology or physiology;mitotic cell cycle process;nucleic acid metabolic process;regulation of glucose transport;cellular response to external stimulus;cell cycle process;nuclear envelope organization;response to starvation;cellular protein complex localization;mRNA transport;cell division;protein complex subunit organization;organic cyclic compound metabolic process;glucose transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;RNA localization;regulation of gene expression;monosaccharide transport;mitotic nuclear division;organic substance biosynthetic process;TOR signaling;cellular protein localization;cellular protein modification process;single-organism transport;multi-organism cellular process;single-organism cellular process;gene silencing by RNA;establishment of localization in cell;response to chemical;small GTPase mediated signal transduction;localization;single-organism localization;cellular localization;organelle organization;response to abiotic stimulus;mitotic sister chromatid segregation;chromosome organization;carbohydrate metabolic process;cellular metabolic process;nuclear pore organization;tRNA metabolic process;single-organism organelle organization;chromosome localization;organelle fission;viral process;protein transport;symbiosis, encompassing mutualism through parasitism;single-organism cellular localization;cellular component disassembly;modification of morphology or physiology of other organism;RNA processing;positive regulation of cellular process; 4;6;3;4;5;5;3;4;4;5;6;4;5;2;6;5;3;9;4;4;4;4;4;4;4;5;7;6;3;8;4;5;4;2;3;5;3;7;4;4;6;6;4;3;4;2;5;3;4;5;3;3;3;5;4;5;8;4;5;4;3;4;4;5;5;2;3;3;5;6;4;5;2;5;5;4;7;4;3;5;3;2;4;3;5;5;4;3;3;4;3;5;1;5;4;5;4;5;3;5;5;5;6;2;4;7;5;6;4;6;6;5;7;3;4;4;2;4;4;4;4;2;4;5;6;6;5;5;4;4;2;8;3;7;2;4;3;2;4;6;4;5;3;4;5;5;5;5;5;5;4;4;4;4;4;5;5;5;5;4;4;5;4;6;6;4;5;4;8;3;5;5;4;5;6;5;4;6;5;6;4;3;3;5;4;3;6;2;3;3;4;3;6;5;4;3;6;7;4;5;5;4;5;4;4;4;3;6;3; GO:0031975;GO:0000775;GO:0000776;GO:0061700;GO:0043234;GO:0031967;GO:0000793;GO:0005829;GO:0043231;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043232;GO:0043229;GO:0005622;GO:0035859;GO:0012505;GO:0098687;GO:0031080;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005635;GO:0000777;GO:0044464;GO:0005623;GO:0005643;GO:0043228;GO:0043227;GO:0043226;GO:0005694;GO:0000779;GO:0032991;GO:0005575; envelope;chromosome, centromeric region;kinetochore;GATOR2 complex;protein complex;organelle envelope;condensed chromosome;cytosol;intracellular membrane-bounded organelle;nuclear part;intracellular part;chromosomal part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular;Seh1-associated complex;endomembrane system;chromosomal region;nuclear pore outer ring;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nuclear envelope;condensed chromosome kinetochore;cell part;cell;nuclear pore;non-membrane-bounded organelle;membrane-bounded organelle;organelle;chromosome;condensed chromosome, centromeric region;macromolecular complex;cellular_component; 3;6;4;4;3;4;6;5;4;4;3;4;2;4;3;3;4;3;5;4;3;4;4;5;4;5;2;2;5;3;3;2;5;7;2;1; K14299 map03013; RNA transport; IPR020472;IPR017986;IPR015943;IPR001680; G-protein beta WD-40 repeat;WD40-repeat-containing domain;WD40/YVTN repeat-like-containing domain;WD40 repeat; nucleus Hs13654288 744.0 YU [Y] Nuclear structure;[U] Intracellular trafficking, secretion, and vesicular transport; Q96EE4 Coiled-coil domain-containing protein 126 OS=Homo sapiens OX=9606 GN=CCDC126 PE=2 SV=2 - [CC126_HUMAN] 1.103 0.852 1.108 1.033 0.9 1.47 1.294600939 0.2843694 1.147777778 0.016486187 1.300469484 0.240280685 1.633333333 0.023281362 GO:0043413;GO:0044249;GO:0034645;GO:0009100;GO:0009101;GO:0044699;GO:0044267;GO:0044710;GO:0006486;GO:0006487;GO:0071704;GO:0009059;GO:1901576;GO:0070085;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0044238;GO:0005975;GO:0044260;GO:0019538;GO:1901135;GO:0044763;GO:0009058;GO:0044237;GO:0043170;GO:1901137; macromolecule glycosylation;cellular biosynthetic process;cellular macromolecule biosynthetic process;glycoprotein metabolic process;glycoprotein biosynthetic process;single-organism process;cellular protein metabolic process;single-organism metabolic process;protein glycosylation;protein N-linked glycosylation;organic substance metabolic process;macromolecule biosynthetic process;organic substance biosynthetic process;glycosylation;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;primary metabolic process;carbohydrate metabolic process;cellular macromolecule metabolic process;protein metabolic process;carbohydrate derivative metabolic process;single-organism cellular process;biosynthetic process;cellular metabolic process;macromolecule metabolic process;carbohydrate derivative biosynthetic process; 6;4;5;5;6;2;5;3;4;5;3;5;4;5;2;6;5;5;1;2;4;3;4;4;4;4;3;3;3;4;5; GO:0016020;GO:0005575;GO:0005576; membrane;cellular_component;extracellular region; 2;1;2; GO:0003674;GO:0008375;GO:0016740;GO:0030144;GO:0003824;GO:0008194;GO:0016757;GO:0016758; molecular_function;acetylglucosaminyltransferase activity;transferase activity;alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity;catalytic activity;UDP-glycosyltransferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups; 1;6;3;7;2;5;4;5; IPR026116;IPR027833; Glycosyltransferase family 18;Domain of unknown function DUF4525; extracellular P04264 Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 - [K2C1_HUMAN] 1.01 0.867 0.994 1.026 1.251 0.795 1.164936563 0.008041585 0.820143885 0.006291927 1.146482122 0.004437657 0.635491607 0.012344964 GO:0007599;GO:0060249;GO:0048585;GO:0007596;GO:0048583;GO:0031348;GO:0072359;GO:0072358;GO:0061436;GO:0031347;GO:0050728;GO:0009611;GO:1900047;GO:0048514;GO:0048518;GO:0048519;GO:0048584;GO:0048871;GO:0044707;GO:0019538;GO:0048878;GO:0002376;GO:0030193;GO:0022603;GO:0050778;GO:0008152;GO:1901342;GO:0043170;GO:0050789;GO:0001568;GO:1900046;GO:0065007;GO:0065008;GO:0048646;GO:0050793;GO:0044710;GO:0042060;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:0006955;GO:0006959;GO:0050818;GO:0050819;GO:0042730;GO:0050896;GO:0050891;GO:0030195;GO:0006956;GO:0033561;GO:0032102;GO:0006954;GO:0032101;GO:0009653;GO:0044699;GO:0051241;GO:0001944;GO:0048513;GO:0001867;GO:1903034;GO:1903035;GO:0032502;GO:0032501;GO:0050878;GO:0050727;GO:0001894;GO:0001895;GO:0006979;GO:0050776;GO:0002684;GO:0048731;GO:0080134;GO:0042592;GO:0061041;GO:0061045;GO:0001525;GO:0007275;GO:0002682;GO:0072376;GO:0045765;GO:0071704;GO:0009605;GO:0043588;GO:0045087;GO:0044767;GO:0030104;GO:0044238;GO:0048856;GO:2000026;GO:0002253;GO:0002252; hemostasis;anatomical structure homeostasis;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;negative regulation of defense response;circulatory system development;cardiovascular system development;establishment of skin barrier;regulation of defense response;negative regulation of inflammatory response;response to wounding;negative regulation of hemostasis;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;positive regulation of response to stimulus;multicellular organismal homeostasis;single-multicellular organism process;protein metabolic process;chemical homeostasis;immune system process;regulation of blood coagulation;regulation of anatomical structure morphogenesis;positive regulation of immune response;metabolic process;regulation of vasculature development;macromolecule metabolic process;regulation of biological process;blood vessel development;regulation of hemostasis;biological regulation;regulation of biological quality;anatomical structure formation involved in morphogenesis;regulation of developmental process;single-organism metabolic process;wound healing;defense response;response to stress;coagulation;biological_process;regulation of multicellular organismal process;immune response;humoral immune response;regulation of coagulation;negative regulation of coagulation;fibrinolysis;response to stimulus;multicellular organismal water homeostasis;negative regulation of blood coagulation;complement activation;regulation of water loss via skin;negative regulation of response to external stimulus;inflammatory response;regulation of response to external stimulus;anatomical structure morphogenesis;single-organism process;negative regulation of multicellular organismal process;vasculature development;animal organ development;complement activation, lectin pathway;regulation of response to wounding;negative regulation of response to wounding;developmental process;multicellular organismal process;regulation of body fluid levels;regulation of inflammatory response;tissue homeostasis;retina homeostasis;response to oxidative stress;regulation of immune response;positive regulation of immune system process;system development;regulation of response to stress;homeostatic process;regulation of wound healing;negative regulation of wound healing;angiogenesis;multicellular organism development;regulation of immune system process;protein activation cascade;regulation of angiogenesis;organic substance metabolic process;response to external stimulus;skin development;innate immune response;single-organism developmental process;water homeostasis;primary metabolic process;anatomical structure development;regulation of multicellular organismal development;activation of immune response;immune effector process; 5;5;3;5;3;4;5;5;6;5;5;4;4;4;2;2;3;4;3;4;5;2;5;4;4;2;5;4;2;4;4;2;3;3;3;3;5;4;3;4;1;3;3;4;4;4;6;2;5;5;4;6;4;5;4;3;2;3;5;4;5;5;4;2;2;4;5;5;6;4;4;3;4;4;4;6;5;4;4;3;3;5;3;3;5;4;3;6;3;3;4;3;3; GO:0099513;GO:0099512;GO:0031982;GO:0016020;GO:0043231;GO:0043230;GO:0044421;GO:0044422;GO:0043232;GO:0043228;GO:0043227;GO:0005856;GO:0045111;GO:0072562;GO:0044430;GO:0044424;GO:0044446;GO:0031012;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0045095;GO:0071944;GO:0005615;GO:0043226;GO:0005882;GO:0005886;GO:1903561;GO:0070062;GO:0005575;GO:0005576; polymeric cytoskeletal fiber;supramolecular fiber;vesicle;membrane;intracellular membrane-bounded organelle;extracellular organelle;extracellular region part;organelle part;intracellular non-membrane-bounded organelle;non-membrane-bounded organelle;membrane-bounded organelle;cytoskeleton;intermediate filament cytoskeleton;blood microparticle;cytoskeletal part;intracellular part;intracellular organelle part;extracellular matrix;nucleus;cell part;intracellular organelle;cell;intracellular;keratin filament;cell periphery;extracellular space;organelle;intermediate filament;plasma membrane;extracellular vesicle;extracellular exosome;cellular_component;extracellular region; 3;2;4;2;4;3;2;2;4;3;3;5;6;3;4;3;3;2;5;2;3;2;3;5;3;3;2;4;3;3;4;1;2; GO:0005198;GO:0060089;GO:0003674;GO:0005488;GO:0030246;GO:0004872; structural molecule activity;molecular transducer activity;molecular_function;binding;carbohydrate binding;receptor activity; 2;2;1;2;3;3; K07605 IPR003054;IPR001664;IPR032444;IPR032449;IPR018039; Keratin, type II;Intermediate filament protein;Keratin type II head;Keratin type II cytoskeletal 1, tail;Intermediate filament protein, conserved site; nucleus O95477 ATP-binding cassette sub-family A member 1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3 - [ABCA1_HUMAN] 1.005 0.999 1.158 0.905 1.054 1.068 1.006006006 nan 0.858633776 nan 1.159159159 nan 1.013282732 nan GO:0006909;GO:0051049;GO:0009165;GO:0044281;GO:0051716;GO:0043207;GO:0009190;GO:0046483;GO:0009607;GO:0009605;GO:0019538;GO:0010887;GO:0010885;GO:0010883;GO:0010888;GO:0009893;GO:0009891;GO:0044085;GO:0035556;GO:0050789;GO:0097006;GO:1901360;GO:0018130;GO:0006629;GO:0009306;GO:0009260;GO:0043412;GO:0032489;GO:0032488;GO:1901293;GO:0044802;GO:0006753;GO:0097305;GO:0097306;GO:0046578;GO:0051174;GO:1901566;GO:0014070;GO:0030819;GO:0030816;GO:0030817;GO:0030814;GO:0030810;GO:0044255;GO:0034380;GO:0042592;GO:0055098;GO:0055094;GO:0055092;GO:0055091;GO:0033993;GO:0032526;GO:0019219;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0019693;GO:0006066;GO:0006796;GO:0006793;GO:0006140;GO:0048523;GO:0048522;GO:0008104;GO:0060155;GO:0007165;GO:0007166;GO:0019915;GO:0044710;GO:0044711;GO:0097035;GO:0010256;GO:0052652;GO:0033036;GO:0051056;GO:0051050;GO:0034204;GO:1902652;GO:0030301;GO:0051707;GO:0010033;GO:0051704;GO:0031667;GO:1900371;GO:0015918;GO:0015850;GO:0015914;GO:0006807;GO:0044267;GO:0044260;GO:0007186;GO:0050793;GO:0009889;GO:0050794;GO:0051235;GO:0051234;GO:0090407;GO:0006897;GO:0032368;GO:0032366;GO:0032367;GO:0050896;GO:0032365;GO:0046390;GO:0051649;GO:0070887;GO:0007040;GO:0009259;GO:0044699;GO:0010562;GO:0016125;GO:0032612;GO:0032611;GO:0071396;GO:0071397;GO:0007033;GO:0030808;GO:0007034;GO:1901137;GO:0030804;GO:1901135;GO:0030801;GO:0010324;GO:0030802;GO:0002237;GO:0034405;GO:0033363;GO:0043933;GO:0072521;GO:0072522;GO:0045935;GO:0045937;GO:0007266;GO:0007265;GO:0007264;GO:0050702;GO:0006497;GO:0044238;GO:0002790;GO:0044237;GO:0080171;GO:0019220;GO:0019222;GO:0048583;GO:1901362;GO:0045981;GO:0071840;GO:0009966;GO:0048869;GO:0008202;GO:0048518;GO:0048519;GO:0006171;GO:0015711;GO:0045184;GO:0042221;GO:0016197;GO:0044700;GO:1901564;GO:0016192;GO:0044707;GO:0016050;GO:0019637;GO:0034377;GO:0022607;GO:0042493;GO:0042157;GO:0042158;GO:0071219;GO:0071216;GO:0033700;GO:0006811;GO:0006810;GO:0006950;GO:0034654;GO:1902531;GO:0046903;GO:0044271;GO:0046907;GO:0045332;GO:0030154;GO:0015833;GO:0035023;GO:0090077;GO:0006139;GO:0032374;GO:0032376;GO:0032371;GO:0032370;GO:0032373;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0030799;GO:0032879;GO:0071407;GO:0001816;GO:0009187;GO:0071222;GO:0071229;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0046058;GO:0007584;GO:0034616;GO:0006911;GO:0009058;GO:0009059;GO:0009117;GO:0051171;GO:0051173;GO:0036315;GO:0036314;GO:0051179;GO:1902578;GO:0051641;GO:1902582;GO:1901615;GO:0080090;GO:0061024;GO:0006820;GO:0070723;GO:0009617;GO:0010878;GO:0010876;GO:0010874;GO:0010875;GO:0048878;GO:0006163;GO:0006164;GO:0019438;GO:1900373;GO:0032940;GO:0032496;GO:1901576;GO:0050701;GO:0016043;GO:0065003;GO:0065007;GO:0065005;GO:0065008;GO:0009719;GO:0009152;GO:0009150;GO:0036211;GO:0008150;GO:0008152;GO:0042632;GO:0006869;GO:0050801;GO:0043691;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010646;GO:0042886;GO:0006996;GO:0055088;GO:0045596;GO:0045595;GO:0001101;GO:0055081;GO:0055086;GO:0008203;GO:0051093;GO:0043170;GO:0038027;GO:0009991;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0050663;GO:0071825;GO:0071827;GO:0033344;GO:0010745;GO:0010742;GO:0010743;GO:0007154;GO:1900542;GO:1900544;GO:0071300;GO:0015748;GO:0015031; phagocytosis;regulation of transport;nucleotide biosynthetic process;small molecule metabolic process;cellular response to stimulus;response to external biotic stimulus;cyclic nucleotide biosynthetic process;heterocycle metabolic process;response to biotic stimulus;response to external stimulus;protein metabolic process;negative regulation of cholesterol storage;regulation of cholesterol storage;regulation of lipid storage;negative regulation of lipid storage;positive regulation of metabolic process;positive regulation of biosynthetic process;cellular component biogenesis;intracellular signal transduction;regulation of biological process;regulation of plasma lipoprotein particle levels;organic cyclic compound metabolic process;heterocycle biosynthetic process;lipid metabolic process;protein secretion;ribonucleotide biosynthetic process;macromolecule modification;regulation of Cdc42 protein signal transduction;Cdc42 protein signal transduction;nucleoside phosphate biosynthetic process;single-organism membrane organization;nucleoside phosphate metabolic process;response to alcohol;cellular response to alcohol;regulation of Ras protein signal transduction;regulation of phosphorus metabolic process;organonitrogen compound biosynthetic process;response to organic cyclic compound;positive regulation of cAMP biosynthetic process;positive regulation of cAMP metabolic process;regulation of cAMP biosynthetic process;regulation of cAMP metabolic process;positive regulation of nucleotide biosynthetic process;cellular lipid metabolic process;high-density lipoprotein particle assembly;homeostatic process;response to low-density lipoprotein particle;response to lipoprotein particle;sterol homeostasis;phospholipid homeostasis;response to lipid;response to retinoic acid;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;ribose phosphate metabolic process;alcohol metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of nucleotide metabolic process;negative regulation of cellular process;positive regulation of cellular process;protein localization;platelet dense granule organization;signal transduction;cell surface receptor signaling pathway;lipid storage;single-organism metabolic process;single-organism biosynthetic process;regulation of membrane lipid distribution;endomembrane system organization;cyclic purine nucleotide metabolic process;macromolecule localization;regulation of small GTPase mediated signal transduction;positive regulation of transport;lipid translocation;secondary alcohol metabolic process;cholesterol transport;response to other organism;response to organic substance;multi-organism process;response to nutrient levels;regulation of purine nucleotide biosynthetic process;sterol transport;organic hydroxy compound transport;phospholipid transport;nitrogen compound metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;G-protein coupled receptor signaling pathway;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;maintenance of location;establishment of localization;organophosphate biosynthetic process;endocytosis;regulation of lipid transport;intracellular sterol transport;intracellular cholesterol transport;response to stimulus;intracellular lipid transport;ribose phosphate biosynthetic process;establishment of localization in cell;cellular response to chemical stimulus;lysosome organization;ribonucleotide metabolic process;single-organism process;positive regulation of phosphorus metabolic process;sterol metabolic process;interleukin-1 production;interleukin-1 beta production;cellular response to lipid;cellular response to cholesterol;vacuole organization;regulation of nucleotide biosynthetic process;vacuolar transport;carbohydrate derivative biosynthetic process;positive regulation of cyclic nucleotide biosynthetic process;carbohydrate derivative metabolic process;positive regulation of cyclic nucleotide metabolic process;membrane invagination;regulation of cyclic nucleotide biosynthetic process;response to molecule of bacterial origin;response to fluid shear stress;secretory granule organization;macromolecular complex subunit organization;purine-containing compound metabolic process;purine-containing compound biosynthetic process;positive regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;Rho protein signal transduction;Ras protein signal transduction;small GTPase mediated signal transduction;interleukin-1 beta secretion;protein lipidation;primary metabolic process;peptide secretion;cellular metabolic process;lytic vacuole organization;regulation of phosphate metabolic process;regulation of metabolic process;regulation of response to stimulus;organic cyclic compound biosynthetic process;positive regulation of nucleotide metabolic process;cellular component organization or biogenesis;regulation of signal transduction;cellular developmental process;steroid metabolic process;positive regulation of biological process;negative regulation of biological process;cAMP biosynthetic process;organic anion transport;establishment of protein localization;response to chemical;endosomal transport;single organism signaling;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;vesicle organization;organophosphate metabolic process;plasma lipoprotein particle assembly;cellular component assembly;response to drug;lipoprotein metabolic process;lipoprotein biosynthetic process;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;phospholipid efflux;ion transport;transport;response to stress;nucleobase-containing compound biosynthetic process;regulation of intracellular signal transduction;secretion;cellular nitrogen compound biosynthetic process;intracellular transport;phospholipid translocation;cell differentiation;peptide transport;regulation of Rho protein signal transduction;foam cell differentiation;nucleobase-containing compound metabolic process;regulation of cholesterol transport;positive regulation of cholesterol transport;regulation of sterol transport;positive regulation of lipid transport;positive regulation of sterol transport;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of cyclic nucleotide metabolic process;regulation of localization;cellular response to organic cyclic compound;cytokine production;cyclic nucleotide metabolic process;cellular response to lipopolysaccharide;cellular response to acid chemical;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;cAMP metabolic process;response to nutrient;response to laminar fluid shear stress;phagocytosis, engulfment;biosynthetic process;macromolecule biosynthetic process;nucleotide metabolic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cellular response to sterol;response to sterol;localization;single-organism localization;cellular localization;single-organism intracellular transport;organic hydroxy compound metabolic process;regulation of primary metabolic process;membrane organization;anion transport;response to cholesterol;response to bacterium;cholesterol storage;lipid localization;regulation of cholesterol efflux;positive regulation of cholesterol efflux;chemical homeostasis;purine nucleotide metabolic process;purine nucleotide biosynthetic process;aromatic compound biosynthetic process;positive regulation of purine nucleotide biosynthetic process;secretion by cell;response to lipopolysaccharide;organic substance biosynthetic process;interleukin-1 secretion;cellular component organization;macromolecular complex assembly;biological regulation;protein-lipid complex assembly;regulation of biological quality;response to endogenous stimulus;purine ribonucleotide biosynthetic process;purine ribonucleotide metabolic process;protein modification process;biological_process;metabolic process;cholesterol homeostasis;lipid transport;ion homeostasis;reverse cholesterol transport;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;amide transport;organelle organization;lipid homeostasis;negative regulation of cell differentiation;regulation of cell differentiation;response to acid chemical;anion homeostasis;nucleobase-containing small molecule metabolic process;cholesterol metabolic process;negative regulation of developmental process;macromolecule metabolic process;apolipoprotein A-I-mediated signaling pathway;response to extracellular stimulus;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;cytokine secretion;protein-lipid complex subunit organization;plasma lipoprotein particle organization;cholesterol efflux;negative regulation of macrophage derived foam cell differentiation;macrophage derived foam cell differentiation;regulation of macrophage derived foam cell differentiation;cell communication;regulation of purine nucleotide metabolic process;positive regulation of purine nucleotide metabolic process;cellular response to retinoic acid;organophosphate ester transport;protein transport; 5;4;6;4;3;4;7;4;3;3;4;4;5;4;3;3;4;3;5;2;3;4;5;4;5;7;5;9;9;5;4;5;5;6;7;5;5;5;8;8;8;8;6;4;5;4;5;4;7;7;5;5;5;6;3;4;3;4;5;5;5;5;4;6;3;3;4;6;4;5;4;3;4;4;4;8;3;6;3;5;6;7;3;4;2;5;7;6;5;6;3;5;4;5;3;4;3;3;3;5;6;5;7;8;2;6;6;4;4;7;6;2;5;6;5;6;6;8;5;6;6;5;7;4;7;5;7;5;4;5;4;5;6;5;6;8;7;6;7;7;3;6;3;6;6;3;3;5;6;2;4;4;5;2;2;9;6;4;3;7;3;4;5;3;5;4;4;4;4;5;6;5;4;7;5;4;3;5;5;5;5;5;6;5;6;8;6;4;7;6;6;4;5;2;2;2;4;7;3;6;4;7;6;5;5;3;5;5;8;4;5;6;3;5;6;4;4;7;6;2;3;3;5;4;4;4;6;7;4;5;4;8;7;5;6;7;5;7;4;5;4;6;3;5;2;6;3;3;8;7;5;1;2;8;5;6;8;4;4;2;5;3;4;5;4;6;4;4;4;7;4;7;3;4;6;4;5;5;4;4;5;5;4;8;5;7;5;4;7;7;6;5;5; GO:0034358;GO:0044424;GO:0044425;GO:0044421;GO:0009897;GO:0031226;GO:0044464;GO:0071944;GO:0005615;GO:0016023;GO:0016021;GO:0034364;GO:0098589;GO:0043231;GO:1990777;GO:0098552;GO:0098857;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0045335;GO:0044444;GO:0016020;GO:0005737;GO:0009986;GO:0045121;GO:0031982;GO:0031988;GO:0005794;GO:0031224;GO:0048471;GO:0097708;GO:0031410;GO:0044459;GO:0005623;GO:0030139;GO:0098805;GO:0005887;GO:0005886;GO:0032994;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;intracellular part;membrane part;extracellular region part;external side of plasma membrane;intrinsic component of plasma membrane;cell part;cell periphery;extracellular space;cytoplasmic, membrane-bounded vesicle;integral component of membrane;high-density lipoprotein particle;membrane region;intracellular membrane-bounded organelle;lipoprotein particle;side of membrane;membrane microdomain;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;phagocytic vesicle;cytoplasmic part;membrane;cytoplasm;cell surface;membrane raft;vesicle;membrane-bounded vesicle;Golgi apparatus;intrinsic component of membrane;perinuclear region of cytoplasm;intracellular vesicle;cytoplasmic vesicle;plasma membrane part;cell;endocytic vesicle;whole membrane;integral component of plasma membrane;plasma membrane;protein-lipid complex;macromolecular complex;cellular_component;extracellular region; 3;3;2;2;4;4;2;3;3;5;4;4;3;4;4;3;4;3;3;3;2;3;7;4;2;4;3;5;4;5;4;3;5;4;5;3;2;6;3;4;3;3;2;1;2; GO:0030226;GO:0000166;GO:0016818;GO:0016817;GO:0005488;GO:1901265;GO:1901363;GO:0015399;GO:0017076;GO:0016787;GO:0015075;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008289;GO:0017127;GO:0001882;GO:0001883;GO:0031267;GO:0005548;GO:0005543;GO:0005319;GO:0051117;GO:0099600;GO:0051020;GO:0022891;GO:0036094;GO:0022892;GO:0019899;GO:0034185;GO:0034186;GO:0005215;GO:0005515;GO:0005102;GO:0022857;GO:0017111;GO:0060089;GO:0008509;GO:0019905;GO:0015405;GO:0003674;GO:0016887;GO:0042626;GO:0042623;GO:0000149;GO:0005524;GO:0003824;GO:0097159;GO:0043167;GO:0030554;GO:0034188;GO:0004888;GO:0032934;GO:0005496;GO:0015485;GO:0097367;GO:0015248;GO:0032549;GO:0022804;GO:0043492;GO:0016462;GO:0035639;GO:0016820;GO:0043178;GO:0038023;GO:0004872;GO:0004871;GO:0043168; apolipoprotein receptor activity;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;binding;nucleoside phosphate binding;heterocyclic compound binding;primary active transmembrane transporter activity;purine nucleotide binding;hydrolase activity;ion transmembrane transporter activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;lipid binding;cholesterol transporter activity;nucleoside binding;purine nucleoside binding;small GTPase binding;phospholipid transporter activity;phospholipid binding;lipid transporter activity;ATPase binding;transmembrane receptor activity;GTPase binding;substrate-specific transmembrane transporter activity;small molecule binding;substrate-specific transporter activity;enzyme binding;apolipoprotein binding;apolipoprotein A-I binding;transporter activity;protein binding;receptor binding;transmembrane transporter activity;nucleoside-triphosphatase activity;molecular transducer activity;anion transmembrane transporter activity;syntaxin binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;molecular_function;ATPase activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;SNARE binding;ATP binding;catalytic activity;organic cyclic compound binding;ion binding;adenyl nucleotide binding;apolipoprotein A-I receptor activity;transmembrane signaling receptor activity;sterol binding;steroid binding;cholesterol binding;carbohydrate derivative binding;sterol transporter activity;ribonucleoside binding;active transmembrane transporter activity;ATPase activity, coupled to movement of substances;pyrophosphatase activity;purine ribonucleoside triphosphate binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;alcohol binding;signaling receptor activity;receptor activity;signal transducer activity;anion binding; 4;4;5;4;2;4;3;5;5;3;5;6;5;6;4;3;6;4;5;6;5;4;4;5;4;5;4;3;3;4;4;5;2;3;4;3;7;2;6;5;6;1;8;6;9;4;6;2;3;3;6;5;4;5;4;6;3;5;5;4;10;6;5;5;4;3;3;2;4; K05641 map02010;map04975; ABC transporters;Fat digestion and absorption; IPR027417;IPR017871;IPR026082;IPR003593;IPR003439; P-loop containing nucleoside triphosphate hydrolase;ABC transporter, conserved site;ABC transporter A, ABCA;AAA+ ATPase domain;ABC transporter-like; plasma membrane Hs21536376 4692.0 IR [I] Lipid transport and metabolism;[R] General function prediction only; Q8TED1 Probable glutathione peroxidase 8 OS=Homo sapiens OX=9606 GN=GPX8 PE=1 SV=2 - [GPX8_HUMAN] 1.69 0.756 0.86 1.187 0.628 1.254 2.235449735 nan 1.890127389 nan 1.137566138 nan 1.996815287 nan GO:0000302;GO:0098754;GO:0009636;GO:0098869;GO:0009987;GO:0006950;GO:0008150;GO:0042221;GO:0006979;GO:1901700;GO:0050896;GO:1990748; response to reactive oxygen species;detoxification;response to toxic substance;cellular oxidant detoxification;cellular process;response to stress;biological_process;response to chemical;response to oxidative stress;response to oxygen-containing compound;response to stimulus;cellular detoxification; 5;2;4;4;2;3;1;3;4;4;2;3; GO:0005783;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0005575;GO:0016021;GO:0016020;GO:0044432;GO:0005788;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044424;GO:0044425;GO:0044422;GO:0012505; endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;cellular_component;integral component of membrane;membrane;endoplasmic reticulum part;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;intracellular part;membrane part;organelle part;endomembrane system; 4;2;3;3;2;3;4;1;4;2;4;5;4;3;2;2;3;3;4;4;3;2;2;3; GO:0003674;GO:0016491;GO:0016684;GO:0016209;GO:0003824;GO:0004602;GO:0004601; molecular_function;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;antioxidant activity;catalytic activity;glutathione peroxidase activity;peroxidase activity; 1;3;4;2;2;4;3; K00432 map00480;map00590;map04918; Glutathione metabolism;Arachidonic acid metabolism;Thyroid hormone synthesis; IPR029760;IPR000889;IPR012336;IPR013376; Glutathione peroxidase conserved site;Glutathione peroxidase;Thioredoxin-like fold;Glutathione peroxidase Gpx7, putative; extracellular Hs15618997 211.0 O [O] Posttranslational modification, protein turnover, chaperones; O14786 Neuropilin-1 OS=Homo sapiens OX=9606 GN=NRP1 PE=1 SV=3 - [NRP1_HUMAN] 1.025 1.117 1.054 0.838 0.974 1.5 0.917636526 nan 0.86036961 nan 0.943598926 nan 1.540041068 nan GO:0051049;GO:0016358;GO:0050678;GO:0014032;GO:0014033;GO:0051716;GO:0014031;GO:0048589;GO:0003158;GO:0048588;GO:0018212;GO:0030916;GO:0030855;GO:1901166;GO:0071600;GO:1990138;GO:0061548;GO:0061549;GO:0060548;GO:0008361;GO:0035272;GO:0001755;GO:0050771;GO:0097485;GO:0022029;GO:0050679;GO:0042325;GO:0042327;GO:0010631;GO:0009605;GO:0019538;GO:0060839;GO:0060322;GO:0021537;GO:0021536;GO:0048562;GO:0021825;GO:0009893;GO:0048568;GO:0060301;GO:0060300;GO:0014812;GO:0031175;GO:0035556;GO:1904835;GO:0050789;GO:0032092;GO:0000904;GO:0000902;GO:0010646;GO:0060788;GO:0043410;GO:0021543;GO:0043412;GO:0072148;GO:0021545;GO:0007350;GO:0048812;GO:0009967;GO:0043393;GO:0048639;GO:0048638;GO:0000165;GO:0010647;GO:0051128;GO:0021649;GO:0021648;GO:0021761;GO:1901998;GO:0038084;GO:0051234;GO:0007413;GO:0060284;GO:1902284;GO:1902285;GO:1902287;GO:0021854;GO:0010632;GO:0021795;GO:0008284;GO:0035239;GO:0010720;GO:0008283;GO:0001558;GO:0001654;GO:0007409;GO:0061298;GO:0061299;GO:0045926;GO:0045927;GO:0030030;GO:0097190;GO:0097191;GO:0018108;GO:0060976;GO:0060977;GO:0060978;GO:0008219;GO:0045446;GO:0035282;GO:0007275;GO:0043067;GO:0043066;GO:0043069;GO:0048598;GO:0006468;GO:0006464;GO:0044767;GO:0044763;GO:0060485;GO:0090259;GO:0040011;GO:0051272;GO:0051271;GO:0040012;GO:0010595;GO:0048858;GO:0040017;GO:0048856;GO:0006796;GO:2000026;GO:0006793;GO:1990791;GO:0048523;GO:0048675;GO:0008104;GO:0021604;GO:0043523;GO:0043524;GO:0007165;GO:0007166;GO:0007167;GO:0036486;GO:0036484;GO:0031345;GO:0031344;GO:0031346;GO:0044710;GO:0070848;GO:0045665;GO:0045664;GO:0045666;GO:0044093;GO:0030307;GO:0033036;GO:0010634;GO:0006935;GO:0010033;GO:0023057;GO:0070887;GO:0061551;GO:0061550;GO:0061552;GO:0048008;GO:0001763;GO:0001764;GO:0097491;GO:0097490;GO:0044267;GO:0007435;GO:0044260;GO:0007431;GO:0070997;GO:0001568;GO:0001569;GO:0043408;GO:0035767;GO:0009887;GO:0006915;GO:0009880;GO:0050793;GO:0009888;GO:0050794;GO:0050918;GO:0051239;GO:1901214;GO:1901215;GO:0050896;GO:0051962;GO:0051961;GO:0051960;GO:2000145;GO:2000147;GO:0043010;GO:0051240;GO:0032102;GO:0032103;GO:0032101;GO:0001944;GO:0072665;GO:0021886;GO:0021885;GO:0021884;GO:0021559;GO:0021888;GO:0044699;GO:0021824;GO:0050767;GO:0010562;GO:0051241;GO:0051246;GO:0051247;GO:0050768;GO:0050769;GO:0010769;GO:0031399;GO:0021954;GO:0021953;GO:0008037;GO:0040013;GO:0008038;GO:0051270;GO:0021675;GO:0090132;GO:0090130;GO:0033365;GO:0048731;GO:0048732;GO:0070374;GO:0070372;GO:0070371;GO:1902668;GO:1902669;GO:0008045;GO:0001525;GO:1902667;GO:0038189;GO:0043583;GO:0035729;GO:0035728;GO:0045937;GO:0061138;GO:0007267;GO:0042221;GO:0035295;GO:0035290;GO:0007507;GO:0036010;GO:0044237;GO:0048522;GO:2001234;GO:2001236;GO:2001237;GO:0019220;GO:0019222;GO:2001233;GO:0048585;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0060326;GO:0071840;GO:0048863;GO:0048864;GO:0009968;GO:0009966;GO:0048869;GO:0097374;GO:0001822;GO:0048513;GO:0048514;GO:0021855;GO:0021856;GO:0010721;GO:0048518;GO:0048519;GO:0042127;GO:0048762;GO:0021636;GO:0021637;GO:0043534;GO:0003002;GO:0060666;GO:0071697;GO:0071696;GO:0044700;GO:0016192;GO:0044707;GO:0050731;GO:0050730;GO:1902946;GO:0060982;GO:0035924;GO:0032535;GO:0061437;GO:0022604;GO:0022603;GO:0021602;GO:0006929;GO:0006928;GO:0051674;GO:0007169;GO:0043170;GO:0042981;GO:0043542;GO:0061439;GO:0090066;GO:0051129;GO:0048640;GO:0016477;GO:0048646;GO:0061564;GO:0006810;GO:0012501;GO:0006950;GO:0048010;GO:0048012;GO:0042330;GO:0007423;GO:0031401;GO:0060600;GO:0030154;GO:0060041;GO:1902533;GO:1902531;GO:0001708;GO:0032270;GO:0060445;GO:0060562;GO:0060560;GO:0032502;GO:0032501;GO:0009987;GO:0060627;GO:0021561;GO:0021562;GO:0072001;GO:0032879;GO:0007420;GO:0048839;GO:0031290;GO:0071363;GO:0050770;GO:0050772;GO:0050673;GO:0010771;GO:0010770;GO:0021800;GO:1902378;GO:0048754;GO:0021987;GO:0007389;GO:0032989;GO:0071704;GO:0071310;GO:0048729;GO:0090596;GO:0030335;GO:0030334;GO:0061441;GO:0061440;GO:0034613;GO:0051174;GO:0051179;GO:0051641;GO:0038190;GO:0001936;GO:0030900;GO:0040008;GO:0080090;GO:0030517;GO:0050920;GO:0050921;GO:0050922;GO:0061438;GO:0061387;GO:0023014;GO:0010604;GO:0043049;GO:0070727;GO:0097102;GO:0097101;GO:0009611;GO:0018193;GO:0060255;GO:0010977;GO:0010976;GO:0010975;GO:0021828;GO:0030516;GO:0048870;GO:0048532;GO:0071526;GO:0060847;GO:1903375;GO:0021785;GO:0021783;GO:0048486;GO:0048485;GO:0048483;GO:0016049;GO:0030182;GO:0060385;GO:0060384;GO:0016043;GO:0071599;GO:0060837;GO:0065007;GO:0065009;GO:0065008;GO:0002040;GO:0002042;GO:0051130;GO:0048468;GO:0036211;GO:0008150;GO:0008152;GO:0045165;GO:0071679;GO:1902336;GO:0030308;GO:0016310;GO:0023056;GO:0009790;GO:0023052;GO:0010648;GO:0023051;GO:0007411;GO:0001667;GO:0009653;GO:0022008;GO:0007417;GO:0022612;GO:0044238;GO:0060429;GO:0045597;GO:0045596;GO:0045595;GO:0051093;GO:0032268;GO:0051094;GO:0051099;GO:0051098;GO:1900122;GO:1900120;GO:0014911;GO:0014910;GO:0031325;GO:0031323;GO:0014909;GO:0010941;GO:0002009;GO:0040007;GO:0048846;GO:0048844;GO:0048842;GO:0048843;GO:0048841;GO:0021879;GO:0021872;GO:0021979;GO:0048666;GO:0048667;GO:0051402;GO:0021612;GO:0021610;GO:0007154;GO:0042471;GO:0048699;GO:0042472;GO:0032990;GO:0007399;GO:0001935;GO:0010594;GO:0045773;GO:0001938;GO:0060846;GO:0001932;GO:0060840;GO:0001934;GO:0001655; regulation of transport;dendrite development;regulation of epithelial cell proliferation;neural crest cell development;neural crest cell differentiation;cellular response to stimulus;mesenchymal cell development;developmental growth;endothelium development;developmental cell growth;peptidyl-tyrosine modification;otic vesicle formation;epithelial cell differentiation;neural crest cell migration involved in autonomic nervous system development;otic vesicle morphogenesis;neuron projection extension;ganglion development;sympathetic ganglion development;negative regulation of cell death;regulation of cell size;exocrine system development;neural crest cell migration;negative regulation of axonogenesis;neuron projection guidance;telencephalon cell migration;positive regulation of epithelial cell proliferation;regulation of phosphorylation;positive regulation of phosphorylation;epithelial cell migration;response to external stimulus;protein metabolic process;endothelial cell fate commitment;head development;telencephalon development;diencephalon development;embryonic organ morphogenesis;substrate-dependent cerebral cortex tangential migration;positive regulation of metabolic process;embryonic organ development;positive regulation of cytokine activity;regulation of cytokine activity;muscle cell migration;neuron projection development;intracellular signal transduction;dorsal root ganglion morphogenesis;regulation of biological process;positive regulation of protein binding;cell morphogenesis involved in differentiation;cell morphogenesis;regulation of cell communication;ectodermal placode formation;positive regulation of MAPK cascade;pallium development;macromolecule modification;epithelial cell fate commitment;cranial nerve development;blastoderm segmentation;neuron projection morphogenesis;positive regulation of signal transduction;regulation of protein binding;positive regulation of developmental growth;regulation of developmental growth;MAPK cascade;positive regulation of cell communication;regulation of cellular component organization;vestibulocochlear nerve structural organization;vestibulocochlear nerve morphogenesis;limbic system development;toxin transport;vascular endothelial growth factor signaling pathway;establishment of localization;axonal fasciculation;regulation of cell development;neuron projection extension involved in neuron projection guidance;semaphorin-plexin signaling pathway involved in neuron projection guidance;semaphorin-plexin signaling pathway involved in axon guidance;hypothalamus development;regulation of epithelial cell migration;cerebral cortex cell migration;positive regulation of cell proliferation;tube morphogenesis;positive regulation of cell development;cell proliferation;regulation of cell growth;eye development;axonogenesis;retina vasculature development in camera-type eye;retina vasculature morphogenesis in camera-type eye;negative regulation of growth;positive regulation of growth;cell projection organization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;peptidyl-tyrosine phosphorylation;coronary vasculature development;coronary vasculature morphogenesis;angiogenesis involved in coronary vascular morphogenesis;cell death;endothelial cell differentiation;segmentation;multicellular organism development;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;embryonic morphogenesis;protein phosphorylation;cellular protein modification process;single-organism developmental process;single-organism cellular process;mesenchyme development;regulation of retinal ganglion cell axon guidance;locomotion;positive regulation of cellular component movement;negative regulation of cellular component movement;regulation of locomotion;positive regulation of endothelial cell migration;cell projection morphogenesis;positive regulation of locomotion;anatomical structure development;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;dorsal root ganglion development;negative regulation of cellular process;axon extension;protein localization;cranial nerve structural organization;regulation of neuron apoptotic process;negative regulation of neuron apoptotic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;ventral trunk neural crest cell migration;trunk neural crest cell migration;negative regulation of cell projection organization;regulation of cell projection organization;positive regulation of cell projection organization;single-organism metabolic process;response to growth factor;negative regulation of neuron differentiation;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of molecular function;positive regulation of cell growth;macromolecule localization;positive regulation of epithelial cell migration;chemotaxis;response to organic substance;negative regulation of signaling;cellular response to chemical stimulus;trigeminal ganglion development;cranial ganglion development;ganglion morphogenesis;platelet-derived growth factor receptor signaling pathway;morphogenesis of a branching structure;neuron migration;sympathetic neuron projection guidance;sympathetic neuron projection extension;cellular protein metabolic process;salivary gland morphogenesis;cellular macromolecule metabolic process;salivary gland development;neuron death;blood vessel development;patterning of blood vessels;regulation of MAPK cascade;endothelial cell chemotaxis;organ morphogenesis;apoptotic process;embryonic pattern specification;regulation of developmental process;tissue development;regulation of cellular process;positive chemotaxis;regulation of multicellular organismal process;regulation of neuron death;negative regulation of neuron death;response to stimulus;positive regulation of nervous system development;negative regulation of nervous system development;regulation of nervous system development;regulation of cell motility;positive regulation of cell motility;camera-type eye development;positive regulation of multicellular organismal process;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;protein localization to vacuole;hypothalamus gonadotrophin-releasing hormone neuron differentiation;forebrain cell migration;forebrain neuron development;trigeminal nerve development;hypothalamus gonadotrophin-releasing hormone neuron development;single-organism process;cerebral cortex tangential migration using cell-axon interactions;regulation of neurogenesis;positive regulation of phosphorus metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;negative regulation of neurogenesis;positive regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;central nervous system neuron development;central nervous system neuron differentiation;cell recognition;negative regulation of locomotion;neuron recognition;regulation of cellular component movement;nerve development;epithelium migration;tissue migration;protein localization to organelle;system development;gland development;positive regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;negative regulation of axon guidance;positive regulation of axon guidance;motor neuron axon guidance;angiogenesis;regulation of axon guidance;neuropilin signaling pathway;ear development;cellular response to hepatocyte growth factor stimulus;response to hepatocyte growth factor;positive regulation of phosphate metabolic process;morphogenesis of a branching epithelium;cell-cell signaling;response to chemical;tube development;trunk segmentation;heart development;protein localization to endosome;cellular metabolic process;positive regulation of cellular process;negative regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;cell chemotaxis;cellular component organization or biogenesis;stem cell differentiation;stem cell development;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;sensory neuron axon guidance;kidney development;animal organ development;blood vessel morphogenesis;hypothalamus cell migration;hypothalamic tangential migration using cell-axon interactions;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;mesenchymal cell differentiation;trigeminal nerve morphogenesis;trigeminal nerve structural organization;blood vessel endothelial cell migration;regionalization;dichotomous subdivision of terminal units involved in salivary gland branching;ectodermal placode morphogenesis;ectodermal placode development;single organism signaling;vesicle-mediated transport;single-multicellular organism process;positive regulation of peptidyl-tyrosine phosphorylation;regulation of peptidyl-tyrosine phosphorylation;protein localization to early endosome;coronary artery morphogenesis;cellular response to vascular endothelial growth factor stimulus;regulation of cellular component size;renal system vasculature development;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;cranial nerve morphogenesis;substrate-dependent cell migration;movement of cell or subcellular component;localization of cell;transmembrane receptor protein tyrosine kinase signaling pathway;macromolecule metabolic process;regulation of apoptotic process;endothelial cell migration;kidney vasculature morphogenesis;regulation of anatomical structure size;negative regulation of cellular component organization;negative regulation of developmental growth;cell migration;anatomical structure formation involved in morphogenesis;axon development;transport;programmed cell death;response to stress;vascular endothelial growth factor receptor signaling pathway;hepatocyte growth factor receptor signaling pathway;taxis;sensory organ development;positive regulation of protein modification process;dichotomous subdivision of an epithelial terminal unit;cell differentiation;retina development in camera-type eye;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;cell fate specification;positive regulation of cellular protein metabolic process;branching involved in salivary gland morphogenesis;epithelial tube morphogenesis;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;cellular process;regulation of vesicle-mediated transport;facial nerve development;vestibulocochlear nerve development;renal system development;regulation of localization;brain development;inner ear development;retinal ganglion cell axon guidance;cellular response to growth factor stimulus;regulation of axonogenesis;positive regulation of axonogenesis;epithelial cell proliferation;negative regulation of cell morphogenesis involved in differentiation;positive regulation of cell morphogenesis involved in differentiation;cerebral cortex tangential migration;VEGF-activated neuropilin signaling pathway involved in axon guidance;branching morphogenesis of an epithelial tube;cerebral cortex development;pattern specification process;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;tissue morphogenesis;sensory organ morphogenesis;positive regulation of cell migration;regulation of cell migration;renal artery morphogenesis;kidney vasculature development;cellular protein localization;regulation of phosphorus metabolic process;localization;cellular localization;VEGF-activated neuropilin signaling pathway;regulation of endothelial cell proliferation;forebrain development;regulation of growth;regulation of primary metabolic process;negative regulation of axon extension;regulation of chemotaxis;positive regulation of chemotaxis;negative regulation of chemotaxis;renal system vasculature morphogenesis;regulation of extent of cell growth;signal transduction by protein phosphorylation;positive regulation of macromolecule metabolic process;otic placode formation;cellular macromolecule localization;endothelial tip cell fate specification;blood vessel endothelial cell fate specification;response to wounding;peptidyl-amino acid modification;regulation of macromolecule metabolic process;negative regulation of neuron projection development;positive regulation of neuron projection development;regulation of neuron projection development;gonadotrophin-releasing hormone neuronal migration to the hypothalamus;regulation of axon extension;cell motility;anatomical structure arrangement;semaphorin-plexin signaling pathway;endothelial cell fate specification;facioacoustic ganglion development;branchiomotor neuron axon guidance;preganglionic parasympathetic fiber development;parasympathetic nervous system development;sympathetic nervous system development;autonomic nervous system development;cell growth;neuron differentiation;axonogenesis involved in innervation;innervation;cellular component organization;otic vesicle development;blood vessel endothelial cell differentiation;biological regulation;regulation of molecular function;regulation of biological quality;sprouting angiogenesis;cell migration involved in sprouting angiogenesis;positive regulation of cellular component organization;cell development;protein modification process;biological_process;metabolic process;cell fate commitment;commissural neuron axon guidance;positive regulation of retinal ganglion cell axon guidance;negative regulation of cell growth;phosphorylation;positive regulation of signaling;embryo development;signaling;negative regulation of cell communication;regulation of signaling;axon guidance;ameboidal-type cell migration;anatomical structure morphogenesis;neurogenesis;central nervous system development;gland morphogenesis;primary metabolic process;epithelium development;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of developmental process;regulation of cellular protein metabolic process;positive regulation of developmental process;positive regulation of binding;regulation of binding;positive regulation of receptor binding;regulation of receptor binding;positive regulation of smooth muscle cell migration;regulation of smooth muscle cell migration;positive regulation of cellular metabolic process;regulation of cellular metabolic process;smooth muscle cell migration;regulation of cell death;morphogenesis of an epithelium;growth;axon extension involved in axon guidance;artery morphogenesis;positive regulation of axon extension involved in axon guidance;negative regulation of axon extension involved in axon guidance;regulation of axon extension involved in axon guidance;forebrain neuron differentiation;forebrain generation of neurons;hypothalamus cell differentiation;neuron development;cell morphogenesis involved in neuron differentiation;neuron apoptotic process;facial nerve structural organization;facial nerve morphogenesis;cell communication;ear morphogenesis;generation of neurons;inner ear morphogenesis;cell part morphogenesis;nervous system development;endothelial cell proliferation;regulation of endothelial cell migration;positive regulation of axon extension;positive regulation of endothelial cell proliferation;blood vessel endothelial cell fate commitment;regulation of protein phosphorylation;artery development;positive regulation of protein phosphorylation;urogenital system development; 4;4;5;7;7;3;6;3;6;4;8;4;6;6;6;5;5;6;4;5;5;6;6;5;5;5;7;7;6;3;4;7;4;4;4;5;6;3;4;8;7;5;5;5;6;2;6;5;5;4;4;6;4;5;6;5;6;6;4;5;4;4;5;4;4;6;5;5;5;8;3;6;5;6;6;7;4;4;5;4;4;5;3;4;5;7;5;4;3;3;4;5;6;8;5;5;5;4;7;6;4;5;6;5;4;7;6;3;3;5;6;2;4;4;3;5;5;3;3;5;4;4;6;3;6;4;5;6;6;4;5;6;8;7;5;5;5;3;5;6;7;6;4;4;3;4;4;4;3;4;7;6;5;8;4;5;6;6;5;6;4;5;5;4;5;6;6;4;6;5;3;4;3;5;3;5;5;2;4;4;5;4;4;6;3;4;4;4;5;7;6;5;7;6;7;2;7;6;5;3;5;5;5;5;6;6;6;6;4;3;5;4;4;5;4;6;4;4;7;7;6;5;5;7;4;5;6;5;7;6;6;5;4;3;4;7;4;8;3;3;5;6;6;6;3;5;3;3;3;5;5;5;2;6;5;4;4;4;7;4;4;4;5;6;5;2;2;4;6;5;6;8;5;7;4;4;3;5;3;8;8;9;6;7;4;6;5;4;4;5;4;3;7;4;6;7;4;4;4;4;4;3;6;4;5;3;8;8;3;4;6;6;5;4;5;5;5;5;6;5;4;2;2;2;4;6;6;5;3;4;4;7;6;7;6;4;5;5;6;7;5;4;4;4;3;5;4;5;5;5;5;5;5;5;2;3;7;6;4;3;4;5;4;4;4;4;5;4;4;5;4;6;7;4;7;4;6;6;6;6;5;3;4;6;6;7;8;5;5;5;5;3;6;5;4;3;5;5;2;3;3;5;6;4;4;5;1;2;5;7;6;4;6;3;5;2;4;3;6;5;3;6;5;5;3;5;4;4;4;3;5;3;5;4;7;6;6;6;4;4;6;4;5;2;7;5;6;6;6;6;5;5;5;6;6;6;5;4;6;7;5;5;5;5;5;5;6;6;7;5;7;5; GO:0099512;GO:0099513;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0030054;GO:0043025;GO:0070161;GO:0005773;GO:0031224;GO:0005912;GO:0044463;GO:0044464;GO:0071944;GO:0005615;GO:0005769;GO:0036477;GO:0016021;GO:0016020;GO:0044297;GO:0042995;GO:0097443;GO:0043234;GO:0043235;GO:0043231;GO:0043232;GO:0005829;GO:0005924;GO:0005925;GO:0044430;GO:0002116;GO:0043228;GO:0043227;GO:0005856;GO:0005768;GO:0030055;GO:0043229;GO:0043226;GO:0045111;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0005737;GO:0043005;GO:0009986;GO:0030427;GO:0030426;GO:0030424;GO:0097708;GO:0005883;GO:0031410;GO:0005623;GO:0005622;GO:0097458;GO:0005882;GO:0005886;GO:0032991;GO:0005575;GO:0005576; supramolecular fiber;polymeric cytoskeletal fiber;intracellular part;membrane part;extracellular region part;organelle part;cell junction;neuronal cell body;anchoring junction;vacuole;intrinsic component of membrane;adherens junction;cell projection part;cell part;cell periphery;extracellular space;early endosome;somatodendritic compartment;integral component of membrane;membrane;cell body;cell projection;sorting endosome;protein complex;receptor complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;cell-substrate adherens junction;focal adhesion;cytoskeletal part;semaphorin receptor complex;non-membrane-bounded organelle;membrane-bounded organelle;cytoskeleton;endosome;cell-substrate junction;intracellular organelle;organelle;intermediate filament cytoskeleton;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;cytoplasm;neuron projection;cell surface;site of polarized growth;growth cone;axon;intracellular vesicle;neurofilament;cytoplasmic vesicle;cell;intracellular;neuron part;intermediate filament;plasma membrane;macromolecular complex;cellular_component;extracellular region; 2;3;3;2;2;2;2;4;3;5;3;4;3;2;3;3;5;4;4;2;3;3;5;3;4;4;4;5;4;5;4;5;3;3;5;4;3;3;2;6;3;4;3;4;4;4;3;3;4;5;4;5;5;2;3;3;4;3;2;1;2; GO:0004714;GO:0004713;GO:0005488;GO:0016773;GO:0016772;GO:0038085;GO:0016740;GO:0099600;GO:0019955;GO:0019199;GO:0005515;GO:0004672;GO:0060089;GO:0046872;GO:0003674;GO:0019838;GO:0016301;GO:0003824;GO:0043169;GO:0043167;GO:0017154;GO:0005021;GO:0015026;GO:0004888;GO:0097367;GO:0043168;GO:0005539;GO:0008201;GO:0038023;GO:1901681;GO:0004872;GO:0004871; transmembrane receptor protein tyrosine kinase activity;protein tyrosine kinase activity;binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;vascular endothelial growth factor binding;transferase activity;transmembrane receptor activity;cytokine binding;transmembrane receptor protein kinase activity;protein binding;protein kinase activity;molecular transducer activity;metal ion binding;molecular_function;growth factor binding;kinase activity;catalytic activity;cation binding;ion binding;semaphorin receptor activity;vascular endothelial growth factor-activated receptor activity;coreceptor activity;transmembrane signaling receptor activity;carbohydrate derivative binding;anion binding;glycosaminoglycan binding;heparin binding;signaling receptor activity;sulfur compound binding;receptor activity;signal transducer activity; 6;7;2;5;4;5;3;4;4;5;3;6;2;5;1;4;5;2;4;3;5;7;4;4;3;4;4;4;3;3;3;2; K06724 map04360;map05166; Axon guidance;HTLV-I infection; IPR000998;IPR008979;IPR022579;IPR000859;IPR000421;IPR013320;IPR014648;IPR027146; MAM domain;Galactose-binding domain-like;Neuropilin, C-terminal;CUB domain;Coagulation factor 5/8 C-terminal domain;Concanavalin A-like lectin/glucanase domain;Neuropilin;Neuropilin-1; endoplasmic reticulum 375011512 61.2 S [S] Function unknown; COG3291 PKD repeat Q9HB19 Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=2 - [PKHA2_HUMAN] 0.886 1.072 1.031 0.613 1.589 0.762 0.826492537 nan 0.385777218 nan 0.961753731 nan 0.479546885 nan GO:0030155;GO:0007160;GO:0050789;GO:0045785;GO:0065007;GO:0048518;GO:0022610;GO:0031589;GO:0010810;GO:0010811;GO:0009987;GO:0050794;GO:0008150;GO:0007155;GO:0001954;GO:0001952;GO:0048522; regulation of cell adhesion;cell-matrix adhesion;regulation of biological process;positive regulation of cell adhesion;biological regulation;positive regulation of biological process;biological adhesion;cell-substrate adhesion;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;cellular process;regulation of cellular process;biological_process;cell adhesion;positive regulation of cell-matrix adhesion;regulation of cell-matrix adhesion;positive regulation of cellular process; 4;5;2;4;2;2;2;4;5;5;2;3;1;3;6;6;3; GO:0043229;GO:0071944;GO:0043227;GO:0005737;GO:0005634;GO:0016020;GO:0043226;GO:0005886;GO:0043234;GO:0032991;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;cell periphery;membrane-bounded organelle;cytoplasm;nucleus;membrane;organelle;plasma membrane;protein complex;macromolecular complex;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;3;4;5;2;2;3;3;2;4;2;2;3;1;3; GO:0050840;GO:0003674;GO:0005488;GO:0001968;GO:0008289;GO:0043236;GO:0005515; extracellular matrix binding;molecular_function;binding;fibronectin binding;lipid binding;laminin binding;protein binding; 3;1;2;4;3;4;3; IPR001849;IPR011993; Pleckstrin homology domain;PH domain-like; cytosol Q14789 Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2 - [GOGB1_HUMAN] 0.941 0.945 1.309 0.893 0.927 0.94 0.995767196 0.874421195 0.963322546 0.338944962 1.385185185 0.079203311 1.014023732 0.85020986 GO:0061024;GO:0071840;GO:0044710;GO:0010256;GO:0018193;GO:0016192;GO:0019538;GO:0018279;GO:1901576;GO:0006888;GO:0044260;GO:0048193;GO:0016043;GO:0044699;GO:0006810;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0051234;GO:0046907;GO:0044765;GO:0043413;GO:0018196;GO:0044249;GO:0034645;GO:0043687;GO:0009987;GO:0007030;GO:1901137;GO:1901135;GO:0043170;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0071704;GO:0044267;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0044237;GO:1902582; membrane organization;cellular component organization or biogenesis;single-organism metabolic process;endomembrane system organization;peptidyl-amino acid modification;vesicle-mediated transport;protein metabolic process;protein N-linked glycosylation via asparagine;organic substance biosynthetic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;Golgi vesicle transport;cellular component organization;single-organism process;transport;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;intracellular transport;single-organism transport;macromolecule glycosylation;peptidyl-asparagine modification;cellular biosynthetic process;cellular macromolecule biosynthetic process;post-translational protein modification;cellular process;Golgi organization;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;organic substance metabolic process;cellular protein metabolic process;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;cellular metabolic process;single-organism intracellular transport; 4;2;3;4;7;5;4;6;4;7;4;6;3;2;4;5;5;1;2;4;3;5;4;6;8;4;5;7;2;5;5;4;4;5;6;4;5;3;5;5;6;3;5;3;4;2;3;3;4;3;4;3;5; GO:0031984;GO:0016021;GO:0016020;GO:0005795;GO:0005794;GO:0005793;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0031224;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005801;GO:0005575;GO:0098791; organelle subcompartment;integral component of membrane;membrane;Golgi stack;Golgi apparatus;endoplasmic reticulum-Golgi intermediate compartment;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intrinsic component of membrane;cytoplasm;organelle membrane;cell part;cell;cis-Golgi network;cellular_component;Golgi subcompartment; 4;4;2;5;4;5;4;4;3;2;2;3;3;3;2;4;3;5;3;4;3;4;3;2;2;5;1;5; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0003723;GO:0044822; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;RNA binding;poly(A) RNA binding; 3;1;2;4;3;5;6; K20478 IPR003106;IPR026202; Leucine zipper, homeobox-associated;Golgin subfamily B member 1; peroxisome A0A075B6I9 Immunoglobulin lambda variable 7-46 OS=Homo sapiens OX=9606 GN=IGLV7-46 PE=3 SV=4 - [LV746_HUMAN] 1.009 0.925 1.133 0.919 1.007 1.073 1.090810811 0.672592024 0.912611718 0.383681622 1.224864865 0.010855716 1.065541212 0.042540611 IPR003599;IPR013106;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular Q01814 Plasma membrane calcium-transporting ATPase 2 OS=Homo sapiens OX=9606 GN=ATP2B2 PE=1 SV=2 - [AT2B2_HUMAN] 1.059 1.536 0.565 0.853 1.464 nan 0.689453125 0.390549455 0.582650273 0.132756482 0.367838542 0.128634496 nan nan GO:0006875;GO:0009628;GO:0007599;GO:1903779;GO:0007595;GO:0051049;GO:0007596;GO:0048468;GO:0098660;GO:0007610;GO:0060088;GO:0003013;GO:0003015;GO:0030182;GO:0032989;GO:0071840;GO:0021692;GO:0044710;GO:0050885;GO:0048869;GO:0055074;GO:0009611;GO:0009612;GO:0048513;GO:0010959;GO:0030855;GO:0021696;GO:0021697;GO:0021694;GO:0046483;GO:0002066;GO:0002064;GO:0002065;GO:0019725;GO:0051050;GO:0007605;GO:0007600;GO:0003008;GO:0044700;GO:1901564;GO:0044707;GO:0070588;GO:0048878;GO:0006163;GO:0060047;GO:0048646;GO:0021684;GO:0021681;GO:0021683;GO:0044281;GO:0048598;GO:0048562;GO:0021533;GO:0042491;GO:0034220;GO:0048568;GO:0055065;GO:0022037;GO:0098771;GO:0032941;GO:0042428;GO:0042490;GO:0021702;GO:0035315;GO:0060322;GO:0009653;GO:0090102;GO:0000902;GO:0010646;GO:0097164;GO:0007626;GO:0016043;GO:0009259;GO:0098662;GO:0051924;GO:0098916;GO:0065007;GO:1901360;GO:0065008;GO:0002093;GO:0030879;GO:0009150;GO:0009887;GO:0008016;GO:0008015;GO:0050954;GO:0006811;GO:0006810;GO:0009888;GO:0042060;GO:0050794;GO:0019637;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:0009581;GO:0051234;GO:0042430;GO:0046903;GO:0051606;GO:0007420;GO:0007423;GO:0050896;GO:0090066;GO:0021680;GO:0032535;GO:1903522;GO:0006812;GO:0006753;GO:0099536;GO:0099537;GO:0050808;GO:0008152;GO:0035637;GO:0050803;GO:0050801;GO:0030154;GO:0009117;GO:0050804;GO:0009790;GO:0034641;GO:0060119;GO:0023052;GO:0023051;GO:0060113;GO:0046068;GO:0008544;GO:0060117;GO:0044699;GO:0007417;GO:0006139;GO:0021549;GO:0072503;GO:0044057;GO:0050974;GO:0043269;GO:0060563;GO:0021953;GO:0032502;GO:0040011;GO:0032501;GO:0050878;GO:0021587;GO:0050877;GO:0060429;GO:0006725;GO:0043270;GO:0048518;GO:0030001;GO:0030003;GO:0031214;GO:0055080;GO:0018958;GO:0055082;GO:0032879;GO:0055085;GO:0055086;GO:0045299;GO:0048839;GO:0021695;GO:0070838;GO:0050910;GO:1901160;GO:1901135;GO:0051928;GO:0048167;GO:0051480;GO:0006816;GO:0006807;GO:0048731;GO:0048732;GO:0009187;GO:0030030;GO:0072511;GO:0072507;GO:0021575;GO:0042592;GO:0050906;GO:0050905;GO:0072521;GO:0007275;GO:0021707;GO:0048840;GO:0050982;GO:0019693;GO:0050789;GO:0071704;GO:0043583;GO:0006874;GO:0098655;GO:0009605;GO:0090596;GO:0048666;GO:0048667;GO:0009582;GO:0009987;GO:0061337;GO:0007589;GO:0044767;GO:0060122;GO:0044765;GO:0000904;GO:0044763;GO:0006873;GO:0007268;GO:0007267;GO:0007154;GO:0022008;GO:0051179;GO:1902578;GO:0042471;GO:0044238;GO:0048699;GO:0042472;GO:0006996;GO:0007399;GO:0009913;GO:0048856;GO:0008361;GO:0044237;GO:0006796;GO:0030902;GO:0006793;GO:1901615; cellular metal ion homeostasis;response to abiotic stimulus;hemostasis;regulation of cardiac conduction;lactation;regulation of transport;blood coagulation;cell development;inorganic ion transmembrane transport;behavior;auditory receptor cell stereocilium organization;circulatory system process;heart process;neuron differentiation;cellular component morphogenesis;cellular component organization or biogenesis;cerebellar Purkinje cell layer morphogenesis;single-organism metabolic process;neuromuscular process controlling balance;cellular developmental process;calcium ion homeostasis;response to wounding;response to mechanical stimulus;animal organ development;regulation of metal ion transport;epithelial cell differentiation;cerebellar cortex morphogenesis;cerebellar cortex formation;cerebellar Purkinje cell layer formation;heterocycle metabolic process;columnar/cuboidal epithelial cell development;epithelial cell development;columnar/cuboidal epithelial cell differentiation;cellular homeostasis;positive regulation of transport;sensory perception of sound;sensory perception;system process;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;calcium ion transmembrane transport;chemical homeostasis;purine nucleotide metabolic process;heart contraction;anatomical structure formation involved in morphogenesis;cerebellar granular layer formation;cerebellar granular layer development;cerebellar granular layer morphogenesis;small molecule metabolic process;embryonic morphogenesis;embryonic organ morphogenesis;cell differentiation in hindbrain;auditory receptor cell differentiation;ion transmembrane transport;embryonic organ development;metal ion homeostasis;metencephalon development;inorganic ion homeostasis;secretion by tissue;serotonin metabolic process;mechanoreceptor differentiation;cerebellar Purkinje cell differentiation;hair cell differentiation;head development;anatomical structure morphogenesis;cochlea development;cell morphogenesis;regulation of cell communication;ammonium ion metabolic process;locomotory behavior;cellular component organization;ribonucleotide metabolic process;inorganic cation transmembrane transport;regulation of calcium ion transport;anterograde trans-synaptic signaling;biological regulation;organic cyclic compound metabolic process;regulation of biological quality;auditory receptor cell morphogenesis;mammary gland development;purine ribonucleotide metabolic process;organ morphogenesis;regulation of heart contraction;blood circulation;sensory perception of mechanical stimulus;ion transport;transport;tissue development;wound healing;regulation of cellular process;organophosphate metabolic process;response to stress;coagulation;biological_process;regulation of multicellular organismal process;detection of external stimulus;establishment of localization;indole-containing compound metabolic process;secretion;detection of stimulus;brain development;sensory organ development;response to stimulus;regulation of anatomical structure size;cerebellar Purkinje cell layer development;regulation of cellular component size;regulation of blood circulation;cation transport;nucleoside phosphate metabolic process;synaptic signaling;trans-synaptic signaling;synapse organization;metabolic process;multicellular organismal signaling;regulation of synapse structure or activity;ion homeostasis;cell differentiation;nucleotide metabolic process;modulation of synaptic transmission;embryo development;cellular nitrogen compound metabolic process;inner ear receptor cell development;signaling;regulation of signaling;inner ear receptor cell differentiation;cGMP metabolic process;epidermis development;auditory receptor cell development;single-organism process;central nervous system development;nucleobase-containing compound metabolic process;cerebellum development;cellular divalent inorganic cation homeostasis;regulation of system process;detection of mechanical stimulus involved in sensory perception;regulation of ion transport;neuroepithelial cell differentiation;central nervous system neuron differentiation;developmental process;locomotion;multicellular organismal process;regulation of body fluid levels;cerebellum morphogenesis;neurological system process;epithelium development;cellular aromatic compound metabolic process;positive regulation of ion transport;positive regulation of biological process;metal ion transport;cellular cation homeostasis;biomineral tissue development;cation homeostasis;phenol-containing compound metabolic process;cellular chemical homeostasis;regulation of localization;transmembrane transport;nucleobase-containing small molecule metabolic process;otolith mineralization;inner ear development;cerebellar cortex development;divalent metal ion transport;detection of mechanical stimulus involved in sensory perception of sound;primary amino compound metabolic process;carbohydrate derivative metabolic process;positive regulation of calcium ion transport;regulation of synaptic plasticity;regulation of cytosolic calcium ion concentration;calcium ion transport;nitrogen compound metabolic process;system development;gland development;cyclic nucleotide metabolic process;cell projection organization;divalent inorganic cation transport;divalent inorganic cation homeostasis;hindbrain morphogenesis;homeostatic process;detection of stimulus involved in sensory perception;neuromuscular process;purine-containing compound metabolic process;multicellular organism development;cerebellar granule cell differentiation;otolith development;detection of mechanical stimulus;ribose phosphate metabolic process;regulation of biological process;organic substance metabolic process;ear development;cellular calcium ion homeostasis;cation transmembrane transport;response to external stimulus;sensory organ morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;detection of abiotic stimulus;cellular process;cardiac conduction;body fluid secretion;single-organism developmental process;inner ear receptor stereocilium organization;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;cellular ion homeostasis;synaptic transmission;cell-cell signaling;cell communication;neurogenesis;localization;single-organism localization;ear morphogenesis;primary metabolic process;generation of neurons;inner ear morphogenesis;organelle organization;nervous system development;epidermal cell differentiation;anatomical structure development;regulation of cell size;cellular metabolic process;phosphate-containing compound metabolic process;hindbrain development;phosphorus metabolic process;organic hydroxy compound metabolic process; 8;3;5;4;5;4;5;4;6;2;6;4;5;6;4;2;4;3;6;4;9;4;4;4;6;6;4;4;4;4;6;5;7;4;3;7;5;3;3;4;3;8;5;6;6;3;4;4;4;4;4;5;5;6;5;4;8;4;7;4;5;7;5;7;4;3;4;5;4;4;3;3;6;7;7;7;2;4;3;5;5;7;4;6;5;6;5;4;4;5;3;4;3;4;1;3;4;3;5;5;3;4;4;2;4;4;4;5;6;5;5;6;4;2;4;4;6;5;6;4;5;4;6;2;3;5;8;6;7;2;5;4;4;8;4;5;5;8;6;2;2;2;4;4;4;5;4;4;2;7;7;5;7;5;5;3;4;4;5;4;4;8;5;5;4;5;5;10;9;3;4;4;7;4;7;8;4;4;4;5;5;4;5;4;5;5;2;3;5;9;6;3;5;5;6;4;2;5;5;3;5;4;5;3;6;8;4;4;6;2;3;6;3;7;5;4;5;7;3;5;3;5;4;4;4; GO:0005783;GO:0031224;GO:0031982;GO:0097458;GO:0016021;GO:0016020;GO:0098589;GO:0044297;GO:0036477;GO:0043230;GO:0042995;GO:0043231;GO:0043025;GO:0030054;GO:0044424;GO:0044421;GO:0043229;GO:0005929;GO:0043227;GO:0043226;GO:0005886;GO:0012505;GO:0044425;GO:0044444;GO:0098590;GO:0031226;GO:0005737;GO:0045177;GO:0044459;GO:0016324;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0045202;GO:0070062;GO:0098805;GO:0005887;GO:1903561;GO:0005575;GO:0005576; endoplasmic reticulum;intrinsic component of membrane;vesicle;neuron part;integral component of membrane;membrane;membrane region;cell body;somatodendritic compartment;extracellular organelle;cell projection;intracellular membrane-bounded organelle;neuronal cell body;cell junction;intracellular part;extracellular region part;intracellular organelle;cilium;membrane-bounded organelle;organelle;plasma membrane;endomembrane system;membrane part;cytoplasmic part;plasma membrane region;intrinsic component of plasma membrane;cytoplasm;apical part of cell;plasma membrane part;apical plasma membrane;cell part;cell;intracellular;cell periphery;synapse;extracellular exosome;whole membrane;integral component of plasma membrane;extracellular vesicle;cellular_component;extracellular region; 4;3;4;3;4;2;3;3;4;3;3;4;4;2;3;2;3;3;3;2;3;3;2;4;4;4;4;3;3;4;2;2;3;3;2;4;3;4;3;1;2; GO:0005215;GO:1901363;GO:0015085;GO:0000166;GO:0035639;GO:0016787;GO:0030165;GO:0008324;GO:0016818;GO:0097367;GO:0016817;GO:0022804;GO:0005388;GO:0022890;GO:0005524;GO:0003674;GO:0005488;GO:0016820;GO:0042625;GO:0042626;GO:0042623;GO:0032549;GO:0017076;GO:0043168;GO:0043169;GO:0022891;GO:0036094;GO:0022892;GO:0003824;GO:0097159;GO:0015075;GO:0016462;GO:0046873;GO:0032559;GO:0032555;GO:0032550;GO:0008022;GO:0015662;GO:0015399;GO:0043167;GO:0005509;GO:1901265;GO:0030554;GO:0005516;GO:0005515;GO:0043492;GO:0016887;GO:0001883;GO:0001882;GO:0022857;GO:0019829;GO:0022853;GO:0017111;GO:0015405;GO:0046872;GO:0032553;GO:0072509;GO:0030899;GO:0019904; transporter activity;heterocyclic compound binding;calcium ion transmembrane transporter activity;nucleotide binding;purine ribonucleoside triphosphate binding;hydrolase activity;PDZ domain binding;cation transmembrane transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;active transmembrane transporter activity;calcium-transporting ATPase activity;inorganic cation transmembrane transporter activity;ATP binding;molecular_function;binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ATPase coupled ion transmembrane transporter activity;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;anion binding;cation binding;substrate-specific transmembrane transporter activity;small molecule binding;substrate-specific transporter activity;catalytic activity;organic cyclic compound binding;ion transmembrane transporter activity;pyrophosphatase activity;metal ion transmembrane transporter activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;protein C-terminus binding;ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;primary active transmembrane transporter activity;ion binding;calcium ion binding;nucleoside phosphate binding;adenyl nucleotide binding;calmodulin binding;protein binding;ATPase activity, coupled to movement of substances;ATPase activity;purine nucleoside binding;nucleoside binding;transmembrane transporter activity;cation-transporting ATPase activity;active ion transmembrane transporter activity;nucleoside-triphosphatase activity;P-P-bond-hydrolysis-driven transmembrane transporter activity;metal ion binding;ribonucleotide binding;divalent inorganic cation transmembrane transporter activity;calcium-dependent ATPase activity;protein domain specific binding; 2;3;9;4;5;3;5;6;5;3;4;4;8;7;6;1;2;5;6;6;9;5;5;4;4;4;3;3;2;3;5;6;8;6;5;6;4;7;5;3;6;4;6;4;3;10;8;5;4;3;7;5;7;6;5;4;8;10;4; K05850 map04020;map04022;map04024;map04261;map04970;map04972; Calcium signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Adrenergic signaling in cardiomyocytes;Salivary secretion;Pancreatic secretion; IPR030322;IPR018303;IPR023298;IPR023299;IPR022141;IPR004014;IPR006068;IPR023214;IPR008250;IPR006408;IPR001757; Plasma membrane calcium-transporting ATPase 2;P-type ATPase, phosphorylation site;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;Plasma membrane calcium transporting P-type ATPase, C-terminal;Cation-transporting P-type ATPase, N-terminal;Cation-transporting P-type ATPase, C-terminal;HAD-like domain;P-type ATPase, A domain;P-type ATPase, subfamily IIB;P-type ATPase; plasma membrane Hs4757808 2449.0 P [P] Inorganic ion transport and metabolism; Q4G0P3 Hydrocephalus-inducing protein homolog OS=Homo sapiens OX=9606 GN=HYDIN PE=1 SV=3 - [HYDIN_HUMAN] 0.901 1.149 0.772 1.035 1.077 1.052 0.784160139 0.322425888 0.961002786 0.99725246 0.671888599 0.686252519 0.976787372 0.747245031 GO:0060541;GO:0022607;GO:0030030;GO:0060438;GO:0060429;GO:0030154;GO:0048468;GO:0002064;GO:0006928;GO:0030855;GO:0060322;GO:0000226;GO:0042384;GO:0003341;GO:0009653;GO:0007275;GO:0044699;GO:0007417;GO:0070925;GO:0021591;GO:0000902;GO:0035082;GO:0048869;GO:0016043;GO:0032989;GO:0048513;GO:0071840;GO:0030031;GO:1904158;GO:0048646;GO:0032502;GO:0032501;GO:0060271;GO:0009987;GO:0009888;GO:0044767;GO:0032990;GO:0044763;GO:0048731;GO:0010927;GO:0048858;GO:0006996;GO:0007017;GO:0007010;GO:0007420;GO:0044707;GO:0001578;GO:0048856;GO:0007018;GO:0007399;GO:1902589;GO:0044085;GO:0008150;GO:0044782; respiratory system development;cellular component assembly;cell projection organization;trachea development;epithelium development;cell differentiation;cell development;epithelial cell development;movement of cell or subcellular component;epithelial cell differentiation;head development;microtubule cytoskeleton organization;cilium assembly;cilium movement;anatomical structure morphogenesis;multicellular organism development;single-organism process;central nervous system development;organelle assembly;ventricular system development;cell morphogenesis;axoneme assembly;cellular developmental process;cellular component organization;cellular component morphogenesis;animal organ development;cellular component organization or biogenesis;cell projection assembly;axonemal central apparatus assembly;anatomical structure formation involved in morphogenesis;developmental process;multicellular organismal process;cilium morphogenesis;cellular process;tissue development;single-organism developmental process;cell part morphogenesis;single-organism cellular process;system development;cellular component assembly involved in morphogenesis;cell projection morphogenesis;organelle organization;microtubule-based process;cytoskeleton organization;brain development;single-multicellular organism process;microtubule bundle formation;anatomical structure development;microtubule-based movement;nervous system development;single-organism organelle organization;cellular component biogenesis;biological_process;cilium organization; 5;4;4;4;5;5;4;5;4;6;4;5;5;6;3;4;2;5;5;5;5;5;4;3;4;4;2;5;5;3;2;2;6;2;4;3;5;3;4;4;5;4;4;5;4;3;6;3;5;5;4;3;1;5; GO:0042995;GO:0043226;GO:0005929;GO:0044463;GO:1990718;GO:0044464;GO:0005930;GO:0005623;GO:0005575;GO:0044447;GO:0097014;GO:0044441;GO:1990716;GO:0044422; cell projection;organelle;cilium;cell projection part;axonemal central pair projection;cell part;axoneme;cell;cellular_component;axoneme part;ciliary plasm;ciliary part;axonemal central apparatus;organelle part; 3;2;3;3;5;2;4;2;1;4;4;3;5;2; K17570 IPR031549;IPR013783;IPR033768;IPR033305; Abnormal spindle-like microcephaly-associated protein, ASH domain;Immunoglobulin-like fold;Hydin adenylate kinase-like domain;Hydrocephalus-inducing protein; plasma membrane P49790 Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2 - [NU153_HUMAN] 0.82 0.325 0.853 0.663 0.302 8.614 2.523076923 nan 2.195364238 nan 2.624615385 nan 28.52317881 nan GO:0051169;GO:0051168;GO:0019221;GO:0019222;GO:0051049;GO:0034605;GO:0032387;GO:0061024;GO:0008104;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0071705;GO:0051716;GO:0016925;GO:0010605;GO:0032239;GO:0071840;GO:0010256;GO:0071310;GO:0075732;GO:0075733;GO:0044419;GO:0032446;GO:0016458;GO:0019058;GO:0051817;GO:0048519;GO:0051704;GO:0032386;GO:0019054;GO:0034470;GO:0051051;GO:0060255;GO:0048583;GO:0051292;GO:0045184;GO:0007077;GO:0051701;GO:0010033;GO:0046483;GO:0044700;GO:0044249;GO:0019538;GO:0010468;GO:0018205;GO:0033554;GO:0019438;GO:0044281;GO:0046718;GO:0022607;GO:0009892;GO:0019080;GO:0044068;GO:0019083;GO:0006997;GO:0006807;GO:0044033;GO:0034660;GO:0050789;GO:0000278;GO:1901576;GO:0044260;GO:0008645;GO:0016043;GO:0008643;GO:0065007;GO:0007049;GO:0065008;GO:0018130;GO:0034097;GO:1903649;GO:0006810;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0009266;GO:0034654;GO:0051236;GO:0051234;GO:0046931;GO:0016070;GO:0050658;GO:0044271;GO:0046907;GO:0071345;GO:0050896;GO:0080135;GO:0009058;GO:0032240;GO:0009059;GO:0046794;GO:0046823;GO:0051170;GO:0015931;GO:0032774;GO:0070271;GO:0070647;GO:0030260;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0052126;GO:0044699;GO:0006139;GO:0000280;GO:0051081;GO:0051179;GO:1903650;GO:0046831;GO:0046832;GO:1902579;GO:1902594;GO:0006996;GO:0008033;GO:0009628;GO:0043687;GO:0009987;GO:0006725;GO:0043412;GO:1903047;GO:0009408;GO:0032879;GO:0044802;GO:0055085;GO:0016482;GO:0018193;GO:0030397;GO:0033036;GO:1900034;GO:0010629;GO:0043170;GO:0051828;GO:0080134;GO:0060341;GO:0043933;GO:0019048;GO:0050657;GO:0090304;GO:0010827;GO:0065003;GO:0022402;GO:0006998;GO:0034622;GO:0007067;GO:0071822;GO:0006399;GO:0015758;GO:0071704;GO:0010467;GO:0044085;GO:0071702;GO:0046822;GO:0006403;GO:0006405;GO:0016032;GO:0015031;GO:0044267;GO:0006461;GO:0006913;GO:0006464;GO:0044766;GO:0044765;GO:0044764;GO:0044763;GO:0031047;GO:0051649;GO:0007154;GO:0043623;GO:0044003;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0051028;GO:0005975;GO:0052192;GO:0044237;GO:0006999;GO:1902589;GO:0044409;GO:0048285;GO:0015749;GO:1902583;GO:0044403;GO:0051806;GO:0022411;GO:0035821;GO:0006396; nuclear transport;nuclear export;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of transport;cellular response to heat;negative regulation of intracellular transport;membrane organization;protein localization;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;nitrogen compound transport;cellular response to stimulus;protein sumoylation;negative regulation of macromolecule metabolic process;regulation of nucleobase-containing compound transport;cellular component organization or biogenesis;endomembrane system organization;cellular response to organic substance;viral penetration into host nucleus;intracellular transport of virus;interspecies interaction between organisms;protein modification by small protein conjugation;gene silencing;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of biological process;multi-organism process;regulation of intracellular transport;modulation by virus of host process;ncRNA processing;negative regulation of transport;regulation of macromolecule metabolic process;regulation of response to stimulus;nuclear pore complex assembly;establishment of protein localization;mitotic nuclear envelope disassembly;interaction with host;response to organic substance;heterocycle metabolic process;single organism signaling;cellular biosynthetic process;protein metabolic process;regulation of gene expression;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;small molecule metabolic process;viral entry into host cell;cellular component assembly;negative regulation of metabolic process;viral gene expression;modulation by symbiont of host cellular process;viral transcription;nucleus organization;nitrogen compound metabolic process;multi-organism metabolic process;ncRNA metabolic process;regulation of biological process;mitotic cell cycle;organic substance biosynthetic process;cellular macromolecule metabolic process;hexose transport;cellular component organization;carbohydrate transport;biological regulation;cell cycle;regulation of biological quality;heterocycle biosynthetic process;response to cytokine;regulation of cytoplasmic transport;transport;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;response to temperature stimulus;nucleobase-containing compound biosynthetic process;establishment of RNA localization;establishment of localization;pore complex assembly;RNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;intracellular transport;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;biosynthetic process;negative regulation of nucleobase-containing compound transport;macromolecule biosynthetic process;transport of virus;negative regulation of nucleocytoplasmic transport;nuclear import;nucleobase-containing compound transport;RNA biosynthetic process;protein complex biogenesis;protein modification by small protein conjugation or removal;entry into host cell;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;movement in host environment;single-organism process;nucleobase-containing compound metabolic process;nuclear division;nuclear envelope disassembly;localization;negative regulation of cytoplasmic transport;regulation of RNA export from nucleus;negative regulation of RNA export from nucleus;multi-organism localization;multi-organism nuclear import;organelle organization;tRNA processing;response to abiotic stimulus;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;macromolecule modification;mitotic cell cycle process;response to heat;regulation of localization;single-organism membrane organization;transmembrane transport;cytosolic transport;peptidyl-amino acid modification;membrane disassembly;macromolecule localization;regulation of cellular response to heat;negative regulation of gene expression;macromolecule metabolic process;entry into other organism involved in symbiotic interaction;regulation of response to stress;regulation of cellular localization;macromolecular complex subunit organization;modulation by virus of host morphology or physiology;nucleic acid transport;nucleic acid metabolic process;regulation of glucose transport;macromolecular complex assembly;cell cycle process;nuclear envelope organization;cellular macromolecular complex assembly;mitotic nuclear division;protein complex subunit organization;tRNA metabolic process;glucose transport;organic substance metabolic process;gene expression;cellular component biogenesis;organic substance transport;regulation of nucleocytoplasmic transport;RNA localization;RNA export from nucleus;viral process;protein transport;cellular protein metabolic process;protein complex assembly;nucleocytoplasmic transport;cellular protein modification process;multi-organism transport;single-organism transport;multi-organism cellular process;single-organism cellular process;gene silencing by RNA;establishment of localization in cell;cell communication;cellular protein complex assembly;modification by symbiont of host morphology or physiology;single-organism localization;cellular localization;locomotion;primary metabolic process;mRNA transport;carbohydrate metabolic process;movement in environment of other organism involved in symbiotic interaction;cellular metabolic process;nuclear pore organization;single-organism organelle organization;entry into host;organelle fission;monosaccharide transport;multi-organism intracellular transport;symbiosis, encompassing mutualism through parasitism;entry into cell of other organism involved in symbiotic interaction;cellular component disassembly;modification of morphology or physiology of other organism;RNA processing; 6;8;6;3;4;5;4;4;4;4;5;5;4;5;3;9;4;5;2;4;5;7;6;3;8;4;5;4;2;2;5;5;7;3;4;3;7;4;6;4;4;4;3;4;4;5;8;4;5;4;6;4;3;4;4;5;5;3;3;6;2;5;4;4;7;3;5;2;4;3;5;5;6;4;3;3;3;5;1;2;4;5;4;3;6;5;5;5;5;6;2;4;3;4;5;5;6;8;6;6;4;7;6;4;2;4;3;4;2;4;6;6;2;5;6;5;3;6;4;8;3;7;2;4;5;5;4;3;4;4;6;7;5;3;5;5;4;4;4;4;4;5;7;5;5;5;4;5;6;5;5;7;8;3;5;3;5;7;4;6;4;5;5;5;7;6;4;4;3;3;5;4;4;6;5;3;3;2;3;6;4;3;3;6;4;5;5;6;5;4;5;4;3;6; GO:0044425;GO:0031974;GO:0031975;GO:0031981;GO:0016020;GO:0098589;GO:0031965;GO:0031967;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0034399;GO:0012505;GO:0044446;GO:0044615;GO:0042405;GO:0042175;GO:0005737;GO:0031090;GO:0005730;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005643;GO:0043228;GO:0005642;GO:0016234;GO:0098805;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane part;membrane-enclosed lumen;envelope;nuclear lumen;membrane;membrane region;nuclear membrane;organelle envelope;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;nuclear periphery;endomembrane system;intracellular organelle part;nuclear pore nuclear basket;nuclear inclusion body;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasm;organelle membrane;nucleolus;nucleus;nuclear envelope;cell part;cell;nuclear pore;non-membrane-bounded organelle;annulate lamellae;inclusion body;whole membrane;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;2;3;5;2;3;4;4;3;4;4;3;4;3;2;3;3;3;5;5;3;3;4;5;3;4;3;5;5;4;2;2;5;3;3;4;3;2;2;1;4; GO:0005198;GO:1901363;GO:0044877;GO:0033218;GO:0005488;GO:0003676;GO:0003677;GO:0005487;GO:0046914;GO:0043169;GO:0097159;GO:0008270;GO:0043167;GO:0042277;GO:0003690;GO:0042802;GO:0005215;GO:0005515;GO:0003674;GO:0003682;GO:0043495;GO:0008139;GO:0017056;GO:0005048;GO:0046872; structural molecule activity;heterocyclic compound binding;macromolecular complex binding;amide binding;binding;nucleic acid binding;DNA binding;nucleocytoplasmic transporter activity;transition metal ion binding;cation binding;organic cyclic compound binding;zinc ion binding;ion binding;peptide binding;double-stranded DNA binding;identical protein binding;transporter activity;protein binding;molecular_function;chromatin binding;protein anchor;nuclear localization sequence binding;structural constituent of nuclear pore;signal sequence binding;metal ion binding; 2;3;3;3;2;4;5;3;6;4;3;7;3;4;6;4;2;3;1;4;4;6;3;5;5; K14296 map03013; RNA transport; IPR001876;IPR013913;IPR026054;IPR018892; Zinc finger, RanBP2-type;Nucleoporin Nup153, N-terminal;Nuclear pore complex protein;Retro-transposon transporting motif; nucleus Hs4826872 2927.0 YU [Y] Nuclear structure;[U] Intracellular trafficking, secretion, and vesicular transport; P07996 Thrombospondin-1 OS=Homo sapiens OX=9606 GN=THBS1 PE=1 SV=2 - [TSP1_HUMAN] 0.932 1 1.123 0.953 0.987 1.148 0.932 0.088116816 0.965552178 0.440892596 1.123 0.009057897 1.163120567 0.006254275 GO:0007599;GO:0051049;GO:0034605;GO:0007596;GO:0016485;GO:0032026;GO:0042035;GO:0044281;GO:0006909;GO:0048266;GO:0048265;GO:0051716;GO:0001666;GO:0000165;GO:0071604;GO:0030595;GO:0060548;GO:0045859;GO:0050678;GO:0046483;GO:0042325;GO:0042327;GO:0010631;GO:0009605;GO:0010633;GO:0019538;GO:0018149;GO:0009892;GO:0009893;GO:0009891;GO:1901342;GO:1901343;GO:1903391;GO:1903392;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0051347;GO:0051346;GO:0001817;GO:0006887;GO:0002687;GO:0002684;GO:0002685;GO:0002682;GO:0002683;GO:0055085;GO:0002688;GO:0019882;GO:2000379;GO:0009889;GO:2000377;GO:0007050;GO:0043412;GO:0043413;GO:0009266;GO:0044723;GO:0032891;GO:0042534;GO:0010557;GO:0010556;GO:0001818;GO:0009967;GO:0006753;GO:0034250;GO:0051129;GO:0051128;GO:1903825;GO:1901566;GO:0014070;GO:1904019;GO:1904018;GO:0009653;GO:0010632;GO:0010876;GO:0008285;GO:0050878;GO:0008283;GO:0043687;GO:0045216;GO:0034329;GO:0050900;GO:0016525;GO:2000181;GO:0097190;GO:0097191;GO:0061041;GO:0022402;GO:0061045;GO:0008219;GO:0007275;GO:0071675;GO:0006486;GO:0043154;GO:2000116;GO:2000117;GO:2000112;GO:0043065;GO:0043067;GO:0043066;GO:0043062;GO:0043069;GO:0043068;GO:0002690;GO:0090092;GO:0019219;GO:0032914;GO:0070085;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0010951;GO:0010955;GO:1903317;GO:0042089;GO:0040011;GO:0051272;GO:0051271;GO:0051270;GO:0010595;GO:0010594;GO:0040017;GO:0010596;GO:0048856;GO:0019693;GO:0006796;GO:2000026;GO:0010755;GO:0006793;GO:0006417;GO:0006140;GO:0010759;GO:0010758;GO:0006412;GO:0048523;GO:0048522;GO:0032147;GO:0007610;GO:0031638;GO:0007160;GO:0007162;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0044710;GO:0045786;GO:0070848;GO:0044093;GO:0044092;GO:0033036;GO:0010634;GO:0006935;GO:0002504;GO:0032695;GO:0032905;GO:0010752;GO:0010038;GO:0010035;GO:0010033;GO:2001027;GO:2001026;GO:0034284;GO:0043405;GO:0006468;GO:0015911;GO:0045321;GO:0010629;GO:0006807;GO:0002604;GO:0002605;GO:0001667;GO:0036065;GO:0044267;GO:0036066;GO:0044260;GO:0001568;GO:0044344;GO:0007049;GO:0035767;GO:0032760;GO:0050793;GO:0050790;GO:0017015;GO:0051248;GO:0050794;GO:0051239;GO:0051234;GO:0051336;GO:0006897;GO:1903959;GO:0032368;GO:0032369;GO:0050896;GO:0051338;GO:0002694;GO:0002696;GO:2000145;GO:1903318;GO:2000147;GO:2000146;GO:0006518;GO:0033674;GO:0051240;GO:1902043;GO:1902041;GO:0032102;GO:0032103;GO:0032101;GO:0001944;GO:0090288;GO:0043406;GO:0007045;GO:0007044;GO:0070887;GO:0009259;GO:0044699;GO:0043408;GO:0090287;GO:0010562;GO:0051241;GO:0051246;GO:0051247;GO:0031399;GO:0010763;GO:0010761;GO:1903034;GO:1903035;GO:1903036;GO:1901700;GO:0046068;GO:0040013;GO:0072593;GO:0034248;GO:0010762;GO:0040012;GO:0043277;GO:0009408;GO:0090132;GO:0090130;GO:1901137;GO:1901135;GO:0042493;GO:0002544;GO:0010324;GO:1905039;GO:0034333;GO:0034332;GO:0050867;GO:0034330;GO:0051094;GO:0015849;GO:0072521;GO:0001525;GO:0009100;GO:0009101;GO:1903960;GO:1903844;GO:1903846;GO:1901360;GO:0010751;GO:0071622;GO:0010757;GO:0071621;GO:0045937;GO:0052547;GO:0010810;GO:0010812;GO:0010754;GO:0042221;GO:0032615;GO:0007263;GO:0070482;GO:0009746;GO:0044238;GO:0006493;GO:0009743;GO:0043271;GO:0044237;GO:0009749;GO:2001234;GO:2001235;GO:2001236;GO:2001237;GO:0019220;GO:0019222;GO:2001233;GO:0048585;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0060326;GO:0045055;GO:0071840;GO:0009968;GO:0009966;GO:0042535;GO:0042533;GO:0048514;GO:0048518;GO:0048519;GO:0042127;GO:0031589;GO:0032655;GO:0015718;GO:1901889;GO:1901888;GO:0015711;GO:0043537;GO:0043536;GO:0043535;GO:0043534;GO:0007179;GO:0007178;GO:0044700;GO:0045727;GO:1901564;GO:0016192;GO:0044707;GO:0044708;GO:0002274;GO:0002376;GO:0033554;GO:0033555;GO:0019637;GO:1902001;GO:0022607;GO:0022603;GO:0006928;GO:0051674;GO:0002468;GO:0048246;GO:0042981;GO:0043542;GO:0033993;GO:0090100;GO:0043549;GO:0090109;GO:1900046;GO:1900047;GO:1904035;GO:0023014;GO:1904037;GO:0016477;GO:1900048;GO:0048646;GO:0015909;GO:0015908;GO:0006811;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0006954;GO:0048731;GO:1902532;GO:1902533;GO:1902531;GO:0050818;GO:0050819;GO:0043410;GO:0046903;GO:0070613;GO:0044271;GO:0051604;GO:0036293;GO:0080134;GO:0031401;GO:0001775;GO:0030155;GO:0006955;GO:0032890;GO:0008543;GO:0009719;GO:0008625;GO:0050865;GO:0032270;GO:0097530;GO:0006508;GO:0071495;GO:0032501;GO:0009987;GO:0006725;GO:2000351;GO:2000353;GO:0043652;GO:0030799;GO:0072577;GO:0032879;GO:0071363;GO:0001953;GO:0001952;GO:0050673;GO:0001816;GO:0071560;GO:0035966;GO:0032570;GO:0034762;GO:0048545;GO:0001819;GO:0009187;GO:0042116;GO:0048041;GO:0043269;GO:0044070;GO:0002578;GO:0051051;GO:0002576;GO:0002577;GO:0031639;GO:0045765;GO:0045766;GO:0071704;GO:0071310;GO:0071706;GO:0071702;GO:0030336;GO:0030335;GO:0030334;GO:0006915;GO:0006911;GO:0051174;GO:0034220;GO:0009058;GO:0009059;GO:0009117;GO:0051171;GO:0051173;GO:0051179;GO:1902578;GO:0046942;GO:0051726;GO:1901654;GO:0071634;GO:0071636;GO:0080090;GO:0050680;GO:0061024;GO:0006820;GO:0050920;GO:0050921;GO:0050922;GO:0051893;GO:0034765;GO:0034766;GO:0051897;GO:0051896;GO:0051895;GO:0034763;GO:0006986;GO:0010605;GO:0010604;GO:0042330;GO:0010608;GO:0043043;GO:0009611;GO:0030168;GO:0043281;GO:0060255;GO:0002581;GO:0002580;GO:0051592;GO:0030162;GO:0040037;GO:0040036;GO:0030511;GO:0048870;GO:0010468;GO:0006163;GO:0030198;GO:0043032;GO:0043030;GO:0030195;GO:0030194;GO:1903792;GO:0032640;GO:0019934;GO:0019935;GO:0032940;GO:1903557;GO:1903555;GO:1901576;GO:0016043;GO:0052548;GO:0065007;GO:0065009;GO:0065008;GO:0002040;GO:0006139;GO:0042060;GO:0009150;GO:0030193;GO:0036211;GO:0008150;GO:0008152;GO:0042730;GO:0043491;GO:0071674;GO:0071774;GO:0006869;GO:0016310;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043086;GO:0043085;GO:0051917;GO:0022610;GO:2000192;GO:0009628;GO:0005975;GO:0055086;GO:0051093;GO:0043604;GO:0032269;GO:0032268;GO:0043603;GO:0050820;GO:0009725;GO:0043170;GO:0010628;GO:0051918;GO:0045861;GO:0045860;GO:0097529;GO:0034976;GO:0000187;GO:0032502;GO:0019932;GO:0032908;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090303;GO:0010942;GO:0010941;GO:0044087;GO:0010467;GO:0010466;GO:0010748;GO:0010749;GO:0010746;GO:0071559;GO:0042108;GO:0042107;GO:2001238;GO:2000191;GO:0007155;GO:0007154;GO:1900542;GO:0030823;GO:0001935;GO:0032680;GO:0044085;GO:0098656;GO:0001932;GO:0044249;GO:0001934;GO:0001937;GO:0001936; hemostasis;regulation of transport;cellular response to heat;blood coagulation;protein processing;response to magnesium ion;regulation of cytokine biosynthetic process;small molecule metabolic process;phagocytosis;behavioral response to pain;response to pain;cellular response to stimulus;response to hypoxia;MAPK cascade;transforming growth factor beta production;leukocyte chemotaxis;negative regulation of cell death;regulation of protein kinase activity;regulation of epithelial cell proliferation;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;epithelial cell migration;response to external stimulus;negative regulation of epithelial cell migration;protein metabolic process;peptide cross-linking;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;regulation of vasculature development;negative regulation of vasculature development;regulation of adherens junction organization;negative regulation of adherens junction organization;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;positive regulation of transferase activity;negative regulation of hydrolase activity;regulation of cytokine production;exocytosis;positive regulation of leukocyte migration;positive regulation of immune system process;regulation of leukocyte migration;regulation of immune system process;negative regulation of immune system process;transmembrane transport;regulation of leukocyte chemotaxis;antigen processing and presentation;positive regulation of reactive oxygen species metabolic process;regulation of biosynthetic process;regulation of reactive oxygen species metabolic process;cell cycle arrest;macromolecule modification;macromolecule glycosylation;response to temperature stimulus;single-organism carbohydrate metabolic process;negative regulation of organic acid transport;regulation of tumor necrosis factor biosynthetic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;negative regulation of cytokine production;positive regulation of signal transduction;nucleoside phosphate metabolic process;positive regulation of cellular amide metabolic process;negative regulation of cellular component organization;regulation of cellular component organization;organic acid transmembrane transport;organonitrogen compound biosynthetic process;response to organic cyclic compound;epithelial cell apoptotic process;positive regulation of vasculature development;anatomical structure morphogenesis;regulation of epithelial cell migration;lipid localization;negative regulation of cell proliferation;regulation of body fluid levels;cell proliferation;post-translational protein modification;cell-cell junction organization;cell junction assembly;leukocyte migration;negative regulation of angiogenesis;negative regulation of blood vessel morphogenesis;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;regulation of wound healing;cell cycle process;negative regulation of wound healing;cell death;multicellular organism development;regulation of mononuclear cell migration;protein glycosylation;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of cysteine-type endopeptidase activity;negative regulation of cysteine-type endopeptidase activity;regulation of cellular macromolecule biosynthetic process;positive regulation of apoptotic process;regulation of programmed cell death;negative regulation of apoptotic process;extracellular structure organization;negative regulation of programmed cell death;positive regulation of programmed cell death;positive regulation of leukocyte chemotaxis;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of nucleobase-containing compound metabolic process;positive regulation of transforming growth factor beta1 production;glycosylation;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;negative regulation of endopeptidase activity;negative regulation of protein processing;regulation of protein maturation;cytokine biosynthetic process;locomotion;positive regulation of cellular component movement;negative regulation of cellular component movement;regulation of cellular component movement;positive regulation of endothelial cell migration;regulation of endothelial cell migration;positive regulation of locomotion;negative regulation of endothelial cell migration;anatomical structure development;ribose phosphate metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;regulation of plasminogen activation;phosphorus metabolic process;regulation of translation;regulation of nucleotide metabolic process;positive regulation of macrophage chemotaxis;regulation of macrophage chemotaxis;translation;negative regulation of cellular process;positive regulation of cellular process;activation of protein kinase activity;behavior;zymogen activation;cell-matrix adhesion;negative regulation of cell adhesion;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;single-organism metabolic process;negative regulation of cell cycle;response to growth factor;positive regulation of molecular function;negative regulation of molecular function;macromolecule localization;positive regulation of epithelial cell migration;chemotaxis;antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;negative regulation of interleukin-12 production;transforming growth factor beta1 production;regulation of cGMP-mediated signaling;response to metal ion;response to inorganic substance;response to organic substance;negative regulation of endothelial cell chemotaxis;regulation of endothelial cell chemotaxis;response to monosaccharide;regulation of MAP kinase activity;protein phosphorylation;plasma membrane long-chain fatty acid transport;leukocyte activation;negative regulation of gene expression;nitrogen compound metabolic process;regulation of dendritic cell antigen processing and presentation;negative regulation of dendritic cell antigen processing and presentation;ameboidal-type cell migration;fucosylation;cellular protein metabolic process;protein O-linked fucosylation;cellular macromolecule metabolic process;blood vessel development;cellular response to fibroblast growth factor stimulus;cell cycle;endothelial cell chemotaxis;positive regulation of tumor necrosis factor production;regulation of developmental process;regulation of catalytic activity;regulation of transforming growth factor beta receptor signaling pathway;negative regulation of protein metabolic process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;endocytosis;regulation of anion transmembrane transport;regulation of lipid transport;negative regulation of lipid transport;response to stimulus;regulation of transferase activity;regulation of leukocyte activation;positive regulation of leukocyte activation;regulation of cell motility;negative regulation of protein maturation;positive regulation of cell motility;negative regulation of cell motility;peptide metabolic process;positive regulation of kinase activity;positive regulation of multicellular organismal process;positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;negative regulation of cellular response to growth factor stimulus;positive regulation of MAP kinase activity;cell-substrate adherens junction assembly;cell-substrate junction assembly;cellular response to chemical stimulus;ribonucleotide metabolic process;single-organism process;regulation of MAPK cascade;regulation of cellular response to growth factor stimulus;positive regulation of phosphorus metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of protein modification process;positive regulation of fibroblast migration;fibroblast migration;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;response to oxygen-containing compound;cGMP metabolic process;negative regulation of locomotion;reactive oxygen species metabolic process;regulation of cellular amide metabolic process;regulation of fibroblast migration;regulation of locomotion;apoptotic cell clearance;response to heat;epithelium migration;tissue migration;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;response to drug;chronic inflammatory response;membrane invagination;carboxylic acid transmembrane transport;adherens junction assembly;adherens junction organization;positive regulation of cell activation;cell junction organization;positive regulation of developmental process;organic acid transport;purine-containing compound metabolic process;angiogenesis;glycoprotein metabolic process;glycoprotein biosynthetic process;negative regulation of anion transmembrane transport;regulation of cellular response to transforming growth factor beta stimulus;positive regulation of cellular response to transforming growth factor beta stimulus;organic cyclic compound metabolic process;negative regulation of nitric oxide mediated signal transduction;regulation of granulocyte chemotaxis;negative regulation of plasminogen activation;granulocyte chemotaxis;positive regulation of phosphate metabolic process;regulation of peptidase activity;regulation of cell-substrate adhesion;negative regulation of cell-substrate adhesion;negative regulation of cGMP-mediated signaling;response to chemical;interleukin-12 production;nitric oxide mediated signal transduction;response to oxygen levels;response to hexose;primary metabolic process;protein O-linked glycosylation;response to carbohydrate;negative regulation of ion transport;cellular metabolic process;response to glucose;negative regulation of apoptotic signaling pathway;positive regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;cell chemotaxis;regulated exocytosis;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;positive regulation of tumor necrosis factor biosynthetic process;tumor necrosis factor biosynthetic process;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;regulation of interleukin-12 production;monocarboxylic acid transport;negative regulation of cell junction assembly;regulation of cell junction assembly;organic anion transport;negative regulation of blood vessel endothelial cell migration;positive regulation of blood vessel endothelial cell migration;regulation of blood vessel endothelial cell migration;blood vessel endothelial cell migration;transforming growth factor beta receptor signaling pathway;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;positive regulation of translation;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;single-organism behavior;myeloid leukocyte activation;immune system process;cellular response to stress;multicellular organismal response to stress;organophosphate metabolic process;fatty acid transmembrane transport;cellular component assembly;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;dendritic cell antigen processing and presentation;macrophage chemotaxis;regulation of apoptotic process;endothelial cell migration;response to lipid;positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of kinase activity;regulation of cell-substrate junction assembly;regulation of hemostasis;negative regulation of hemostasis;regulation of epithelial cell apoptotic process;signal transduction by protein phosphorylation;positive regulation of epithelial cell apoptotic process;cell migration;positive regulation of hemostasis;anatomical structure formation involved in morphogenesis;long-chain fatty acid transport;fatty acid transport;ion transport;transport;defense response;programmed cell death;response to stress;coagulation;inflammatory response;system development;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of coagulation;negative regulation of coagulation;positive regulation of MAPK cascade;secretion;regulation of protein processing;cellular nitrogen compound biosynthetic process;protein maturation;response to decreased oxygen levels;regulation of response to stress;positive regulation of protein modification process;cell activation;regulation of cell adhesion;immune response;regulation of organic acid transport;fibroblast growth factor receptor signaling pathway;response to endogenous stimulus;extrinsic apoptotic signaling pathway via death domain receptors;regulation of cell activation;positive regulation of cellular protein metabolic process;granulocyte migration;proteolysis;cellular response to endogenous stimulus;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of endothelial cell apoptotic process;positive regulation of endothelial cell apoptotic process;engulfment of apoptotic cell;regulation of cyclic nucleotide metabolic process;endothelial cell apoptotic process;regulation of localization;cellular response to growth factor stimulus;negative regulation of cell-matrix adhesion;regulation of cell-matrix adhesion;epithelial cell proliferation;cytokine production;cellular response to transforming growth factor beta stimulus;response to topologically incorrect protein;response to progesterone;regulation of transmembrane transport;response to steroid hormone;positive regulation of cytokine production;cyclic nucleotide metabolic process;macrophage activation;focal adhesion assembly;regulation of ion transport;regulation of anion transport;negative regulation of antigen processing and presentation;negative regulation of transport;platelet degranulation;regulation of antigen processing and presentation;plasminogen activation;regulation of angiogenesis;positive regulation of angiogenesis;organic substance metabolic process;cellular response to organic substance;tumor necrosis factor superfamily cytokine production;organic substance transport;negative regulation of cell migration;positive regulation of cell migration;regulation of cell migration;apoptotic process;phagocytosis, engulfment;regulation of phosphorus metabolic process;ion transmembrane transport;biosynthetic process;macromolecule biosynthetic process;nucleotide metabolic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;localization;single-organism localization;carboxylic acid transport;regulation of cell cycle;response to ketone;regulation of transforming growth factor beta production;positive regulation of transforming growth factor beta production;regulation of primary metabolic process;negative regulation of epithelial cell proliferation;membrane organization;anion transport;regulation of chemotaxis;positive regulation of chemotaxis;negative regulation of chemotaxis;regulation of focal adhesion assembly;regulation of ion transmembrane transport;negative regulation of ion transmembrane transport;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;negative regulation of focal adhesion assembly;negative regulation of transmembrane transport;response to unfolded protein;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;taxis;posttranscriptional regulation of gene expression;peptide biosynthetic process;response to wounding;platelet activation;regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of macromolecule metabolic process;negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;response to calcium ion;regulation of proteolysis;negative regulation of fibroblast growth factor receptor signaling pathway;regulation of fibroblast growth factor receptor signaling pathway;positive regulation of transforming growth factor beta receptor signaling pathway;cell motility;regulation of gene expression;purine nucleotide metabolic process;extracellular matrix organization;positive regulation of macrophage activation;regulation of macrophage activation;negative regulation of blood coagulation;positive regulation of blood coagulation;negative regulation of anion transport;tumor necrosis factor production;cGMP-mediated signaling;cyclic-nucleotide-mediated signaling;secretion by cell;positive regulation of tumor necrosis factor superfamily cytokine production;regulation of tumor necrosis factor superfamily cytokine production;organic substance biosynthetic process;cellular component organization;regulation of endopeptidase activity;biological regulation;regulation of molecular function;regulation of biological quality;sprouting angiogenesis;nucleobase-containing compound metabolic process;wound healing;purine ribonucleotide metabolic process;regulation of blood coagulation;protein modification process;biological_process;metabolic process;fibrinolysis;protein kinase B signaling;mononuclear cell migration;response to fibroblast growth factor;lipid transport;phosphorylation;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;positive regulation of catalytic activity;regulation of fibrinolysis;biological adhesion;negative regulation of fatty acid transport;response to abiotic stimulus;carbohydrate metabolic process;nucleobase-containing small molecule metabolic process;negative regulation of developmental process;amide biosynthetic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;positive regulation of coagulation;response to hormone;macromolecule metabolic process;positive regulation of gene expression;negative regulation of fibrinolysis;negative regulation of proteolysis;positive regulation of protein kinase activity;myeloid leukocyte migration;response to endoplasmic reticulum stress;activation of MAPK activity;developmental process;second-messenger-mediated signaling;regulation of transforming growth factor beta1 production;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of wound healing;positive regulation of cell death;regulation of cell death;regulation of cellular component biogenesis;gene expression;negative regulation of peptidase activity;negative regulation of plasma membrane long-chain fatty acid transport;regulation of nitric oxide mediated signal transduction;regulation of plasma membrane long-chain fatty acid transport;response to transforming growth factor beta;positive regulation of cytokine biosynthetic process;cytokine metabolic process;positive regulation of extrinsic apoptotic signaling pathway;regulation of fatty acid transport;cell adhesion;cell communication;regulation of purine nucleotide metabolic process;regulation of cGMP metabolic process;endothelial cell proliferation;regulation of tumor necrosis factor production;cellular component biogenesis;anion transmembrane transport;regulation of protein phosphorylation;cellular biosynthetic process;positive regulation of protein phosphorylation;negative regulation of endothelial cell proliferation;regulation of endothelial cell proliferation; 5;4;5;5;6;6;5;4;5;4;5;3;4;5;5;4;4;7;5;4;7;7;6;3;4;4;7;3;3;4;5;4;5;5;9;5;8;2;6;6;4;5;4;3;4;3;3;4;5;3;5;4;5;5;5;6;4;4;4;6;5;5;4;4;5;5;4;4;5;5;5;7;4;3;4;4;4;4;3;7;5;5;3;5;5;5;6;6;4;5;4;4;5;4;7;8;9;6;6;5;6;4;5;5;5;5;5;6;5;6;3;4;3;8;7;6;5;2;4;4;4;5;5;3;5;3;5;5;4;8;4;6;6;6;6;6;3;3;9;2;7;5;4;4;5;6;7;3;4;5;4;4;3;4;4;4;5;6;6;5;4;4;5;5;6;7;7;8;3;5;3;5;5;5;6;5;6;4;4;5;4;6;6;3;4;6;5;3;3;3;5;6;6;5;4;2;5;4;4;4;6;4;4;5;7;3;7;7;4;4;4;5;4;7;7;6;4;6;2;6;4;5;3;5;5;6;6;6;5;4;4;4;8;3;4;5;6;3;6;4;5;4;5;4;4;6;5;6;6;6;4;4;3;5;5;4;5;6;6;5;4;4;6;6;8;5;6;6;5;5;6;3;5;7;4;7;3;5;5;4;3;8;5;5;6;6;6;3;5;3;3;3;5;5;5;6;2;4;4;6;6;4;2;2;4;4;5;7;5;4;6;6;6;6;8;6;7;3;6;4;5;3;3;4;2;4;4;4;7;4;4;4;3;4;5;6;7;5;5;6;5;4;4;7;4;7;4;4;3;7;6;5;4;4;5;3;4;5;4;5;5;5;4;4;6;5;7;5;5;5;4;6;4;4;3;5;6;3;7;4;5;5;5;4;2;2;4;8;8;7;7;8;3;6;6;6;4;4;5;4;6;4;5;4;7;5;6;5;6;4;3;7;4;8;5;5;3;5;5;5;5;5;5;6;6;5;5;3;5;6;4;4;2;3;6;4;5;5;5;4;5;4;6;4;4;4;6;5;5;6;6;6;4;5;4;4;3;6;6;4;5;7;4;5;5;6;6;5;5;5;3;5;6;5;5;5;5;5;5;6;8;7;4;5;5;4;3;7;2;3;3;5;4;5;7;5;5;1;2;6;6;4;4;5;6;3;3;4;2;4;5;3;4;4;5;5;6;2;5;3;4;4;3;6;5;5;5;4;4;4;5;3;6;8;4;5;8;2;6;6;5;5;4;4;4;5;4;4;3;5;7;6;6;7;4;5;5;6;6;3;4;7;8;5;6;3;6;7;4;7;6;6; GO:0005788;GO:0034774;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0044464;GO:0016528;GO:0016529;GO:0071944;GO:0005615;GO:0070013;GO:0016023;GO:0016020;GO:0099503;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0044433;GO:0044432;GO:0030141;GO:0060205;GO:0031091;GO:0031093;GO:0098552;GO:0043227;GO:0005783;GO:0031974;GO:0043229;GO:0005622;GO:0043226;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0031012;GO:0009986;GO:0070062;GO:0031988;GO:0032991;GO:0005576;GO:0005737;GO:0097708;GO:0031410;GO:0044459;GO:0005623;GO:0031983;GO:0005886;GO:1903561;GO:0005575;GO:0005577; endoplasmic reticulum lumen;secretory granule lumen;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;cell part;sarcoplasm;sarcoplasmic reticulum;cell periphery;extracellular space;intracellular organelle lumen;cytoplasmic, membrane-bounded vesicle;membrane;secretory vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytoplasmic vesicle part;endoplasmic reticulum part;secretory granule;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;platelet alpha granule lumen;side of membrane;membrane-bounded organelle;endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;intracellular;organelle;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;extracellular matrix;cell surface;extracellular exosome;membrane-bounded vesicle;macromolecular complex;extracellular region;cytoplasm;intracellular vesicle;cytoplasmic vesicle;plasma membrane part;cell;vesicle lumen;plasma membrane;extracellular vesicle;cellular_component;fibrinogen complex; 5;5;3;2;2;2;4;2;5;5;3;3;4;5;2;6;3;3;4;3;4;4;4;5;5;6;3;3;4;2;3;3;2;3;4;3;4;2;3;4;5;2;2;4;4;5;3;2;4;3;3;1;3; GO:0043394;GO:0050840;GO:0050839;GO:0005488;GO:0050431;GO:1901681;GO:0005509;GO:0008289;GO:0016597;GO:0043236;GO:0036094;GO:0070052;GO:0070051;GO:0019955;GO:0001948;GO:0032403;GO:0001786;GO:0005515;GO:0003674;GO:0005102;GO:0005518;GO:0072341;GO:0046872;GO:0044877;GO:0019838;GO:0031406;GO:0005543;GO:0043169;GO:0043167;GO:0042802;GO:0071813;GO:0071814;GO:0030169;GO:0097367;GO:0001968;GO:0005539;GO:0017134;GO:0008201;GO:0043177;GO:0005178;GO:0043168; proteoglycan binding;extracellular matrix binding;cell adhesion molecule binding;binding;transforming growth factor beta binding;sulfur compound binding;calcium ion binding;lipid binding;amino acid binding;laminin binding;small molecule binding;collagen V binding;fibrinogen binding;cytokine binding;glycoprotein binding;protein complex binding;phosphatidylserine binding;protein binding;molecular_function;receptor binding;collagen binding;modified amino acid binding;metal ion binding;macromolecular complex binding;growth factor binding;carboxylic acid binding;phospholipid binding;cation binding;ion binding;identical protein binding;lipoprotein particle binding;protein-lipid complex binding;low-density lipoprotein particle binding;carbohydrate derivative binding;fibronectin binding;glycosaminoglycan binding;fibroblast growth factor binding;heparin binding;organic acid binding;integrin binding;anion binding; 5;3;4;2;5;3;6;3;6;4;3;6;5;4;4;4;4;3;1;4;5;3;5;3;4;5;4;4;3;4;5;4;6;3;4;4;5;4;4;5;4; K16857 map04015;map04115;map04145;map04151;map04350;map04510;map04512;map05144;map05205;map05206;map05219; Rap1 signaling pathway;p53 signaling pathway;Phagosome;PI3K-Akt signaling pathway;TGF-beta signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria;Proteoglycans in cancer;MicroRNAs in cancer;Bladder cancer; IPR028974;IPR013320;IPR017897;IPR000742;IPR008859;IPR001007;IPR000884;IPR001881;IPR013032;IPR028499;IPR001791;IPR003367; TSP type-3 repeat;Concanavalin A-like lectin/glucanase domain;Thrombospondin, type 3 repeat;EGF-like domain;Thrombospondin, C-terminal;VWFC domain;Thrombospondin type-1 (TSP1) repeat;EGF-like calcium-binding domain;EGF-like, conserved site;Thrombospondin-1;Laminin G domain;Thrombospondin, type 3-like repeat; extracellular Hs4507485 2410.0 W [W] Extracellular structures; P13671 Complement component C6 OS=Homo sapiens OX=9606 GN=C6 PE=1 SV=3 - [CO6_HUMAN] 0.984 0.904 1.145 0.914 0.927 0.894 1.088495575 0.455295884 0.985976268 0.348908818 1.26659292 5.05E-07 0.964401294 0.082510372 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048514;GO:0048518;GO:0065007;GO:2000259;GO:0019724;GO:0060255;GO:2000257;GO:0032268;GO:0030162;GO:0002443;GO:0002673;GO:0009605;GO:0044707;GO:0019538;GO:0002376;GO:0030449;GO:0009893;GO:0022603;GO:0002922;GO:1901342;GO:0002920;GO:0019835;GO:0044267;GO:0044260;GO:0001568;GO:0002684;GO:0002682;GO:0045917;GO:0048646;GO:0001969;GO:0050793;GO:0050794;GO:0006952;GO:0006950;GO:1904018;GO:0008150;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0010604;GO:0070613;GO:0051604;GO:0050896;GO:0002697;GO:1903319;GO:0001970;GO:0006956;GO:1903317;GO:0002699;GO:0008152;GO:0032101;GO:0051246;GO:0009611;GO:0009790;GO:0009792;GO:0009653;GO:0044699;GO:0001701;GO:0051240;GO:0001944;GO:0051247;GO:0032270;GO:0006508;GO:0043009;GO:1903034;GO:0032502;GO:0032501;GO:0009987;GO:0001905;GO:0016485;GO:0050776;GO:0002460;GO:0051094;GO:0050778;GO:0043170;GO:0051239;GO:0010628;GO:0048731;GO:0080134;GO:0031325;GO:0031323;GO:0001525;GO:0007275;GO:0072376;GO:0045765;GO:0045766;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0044767;GO:0002449;GO:0045862;GO:0016064;GO:0010954;GO:0044238;GO:0048856;GO:0044237;GO:2000026;GO:0002250;GO:0002253;GO:0002252;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;blood vessel morphogenesis;positive regulation of biological process;biological regulation;positive regulation of protein activation cascade;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of cellular protein metabolic process;regulation of proteolysis;leukocyte mediated immunity;regulation of acute inflammatory response;response to external stimulus;single-multicellular organism process;protein metabolic process;immune system process;regulation of complement activation;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;positive regulation of humoral immune response;regulation of vasculature development;regulation of humoral immune response;cytolysis;cellular protein metabolic process;cellular macromolecule metabolic process;blood vessel development;positive regulation of immune system process;regulation of immune system process;positive regulation of complement activation;anatomical structure formation involved in morphogenesis;regulation of activation of membrane attack complex;regulation of developmental process;regulation of cellular process;defense response;response to stress;positive regulation of vasculature development;biological_process;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;positive regulation of macromolecule metabolic process;regulation of protein processing;protein maturation;response to stimulus;regulation of immune effector process;positive regulation of protein maturation;positive regulation of activation of membrane attack complex;complement activation;regulation of protein maturation;positive regulation of immune effector process;metabolic process;regulation of response to external stimulus;regulation of protein metabolic process;response to wounding;embryo development;embryo development ending in birth or egg hatching;anatomical structure morphogenesis;single-organism process;in utero embryonic development;positive regulation of multicellular organismal process;vasculature development;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;proteolysis;chordate embryonic development;regulation of response to wounding;developmental process;multicellular organismal process;cellular process;activation of membrane attack complex;protein processing;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of developmental process;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;positive regulation of gene expression;system development;regulation of response to stress;positive regulation of cellular metabolic process;regulation of cellular metabolic process;angiogenesis;multicellular organism development;protein activation cascade;regulation of angiogenesis;positive regulation of angiogenesis;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;single-organism developmental process;lymphocyte mediated immunity;positive regulation of proteolysis;immunoglobulin mediated immune response;positive regulation of protein processing;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of multicellular organismal development;adaptive immune response;activation of immune response;immune effector process;positive regulation of cellular process; 4;3;3;3;5;5;5;5;3;5;4;2;2;4;6;4;4;5;6;4;6;3;3;4;2;5;3;4;5;5;5;3;5;4;4;3;3;5;3;6;3;3;4;3;4;1;5;3;6;5;4;4;7;5;2;4;6;6;4;6;4;2;4;5;4;5;6;3;2;8;3;5;5;5;5;7;5;2;2;2;5;6;4;5;3;4;4;3;5;4;4;4;4;4;4;3;5;5;2;3;5;5;4;3;5;6;7;7;3;3;3;4;4;3;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0043226;GO:0031224;GO:0031226;GO:0046930;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0098797;GO:0070062;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0098796;GO:0005576;GO:0005579; vesicle;integral component of membrane;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;organelle;intrinsic component of membrane;intrinsic component of plasma membrane;pore complex;plasma membrane part;cell part;cell;cell periphery;plasma membrane protein complex;extracellular exosome;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;membrane protein complex;extracellular region;membrane attack complex; 4;4;2;3;3;2;2;3;2;3;4;4;3;2;2;3;4;4;4;3;3;2;1;3;2;5; K03995 map04610;map05020;map05322; Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus; IPR023415;IPR002172;IPR020864;IPR003884;IPR020863;IPR000436;IPR001862;IPR000884;IPR002350; Low-density lipoprotein (LDL) receptor class A, conserved site;Low-density lipoprotein (LDL) receptor class A repeat;Membrane attack complex component/perforin (MACPF) domain;Factor I / membrane attack complex;Membrane attack complex component/perforin domain, conserved site;Sushi/SCR/CCP domain;Membrane attack complex component/perforin/complement C9;Thrombospondin type-1 (TSP1) repeat;Kazal domain; extracellular A0A075B6I0 Immunoglobulin lambda variable 8-61 OS=Homo sapiens OX=9606 GN=IGLV8-61 PE=3 SV=7 - [LV861_HUMAN] 1.309 0.536 1.516 1.217 0.471 1.725 2.442164179 0.004065658 2.583864119 0.003506033 2.828358209 0.001353243 3.662420382 0.017126757 IPR003599;IPR013106;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular Q659A1 Little elongation complex subunit 2 OS=Homo sapiens OX=9606 GN=ICE2 PE=1 SV=2 - [ICE2_HUMAN] 1.239 0.864 1.037 1.177 0.905 0.902 1.434027778 nan 1.300552486 nan 1.200231481 nan 0.996685083 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010604;GO:0098781;GO:0048518;GO:0006383;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0034660;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0009301;GO:0016070;GO:0016073;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0006359;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:1902680;GO:0010628;GO:0045945;GO:0042795;GO:0042796;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0006807;GO:0090304;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;ncRNA transcription;positive regulation of biological process;transcription from RNA polymerase III promoter;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;ncRNA metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;snRNA transcription;RNA metabolic process;snRNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;regulation of transcription from RNA polymerase III promoter;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase III promoter;snRNA transcription from RNA polymerase II promoter;snRNA transcription from RNA polymerase III promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nitrogen compound metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;7;2;7;4;6;4;5;3;4;6;4;7;4;4;2;7;5;4;3;1;2;5;8;5;7;5;6;5;5;6;7;6;4;4;5;4;7;2;4;7;6;5;5;6;5;7;8;8;5;5;4;4;3;5;6;2;3;5;5;5;5;3;5;4;4;3;3;3; GO:0031974;GO:0031981;GO:0035363;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0043228;GO:0000785;GO:0043227;GO:0043226;GO:0016604;GO:0005654;GO:0044446;GO:0008023;GO:0005634;GO:0044451;GO:0035327;GO:0044464;GO:0005623;GO:0005622;GO:0005694;GO:0032991;GO:0005575;GO:0070013;GO:0015030; membrane-enclosed lumen;nuclear lumen;histone locus body;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;non-membrane-bounded organelle;chromatin;membrane-bounded organelle;organelle;nuclear body;nucleoplasm;intracellular organelle part;transcription elongation factor complex;nucleus;nucleoplasm part;transcriptionally active chromatin;cell part;cell;intracellular;chromosome;macromolecular complex;cellular_component;intracellular organelle lumen;Cajal body; 2;5;7;3;4;4;3;4;3;4;2;3;3;3;3;2;6;5;3;4;5;5;4;2;2;3;5;2;1;4;7; IPR019535; Little elongation complex subunit 2 , C-terminal; nucleus Q9UBC2 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1 - [EP15R_HUMAN] 0.699 0.922 1.392 1.572 0.632 1.088 0.75813449 nan 2.487341772 nan 1.509761388 nan 1.721518987 nan GO:0007173;GO:0048585;GO:0007167;GO:0048583;GO:0042059;GO:0042058;GO:0023057;GO:0023052;GO:0007165;GO:0007166;GO:0023051;GO:0007169;GO:1901184;GO:0010646;GO:0044699;GO:0051716;GO:1901185;GO:0009968;GO:0009966;GO:0050789;GO:0065007;GO:0048519;GO:0009987;GO:0038127;GO:0006810;GO:0050794;GO:0008150;GO:0007154;GO:0051234;GO:0051179;GO:0044700;GO:0006897;GO:0016192;GO:0050896;GO:0044763;GO:0048523;GO:0010648; epidermal growth factor receptor signaling pathway;negative regulation of response to stimulus;enzyme linked receptor protein signaling pathway;regulation of response to stimulus;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;negative regulation of signaling;signaling;signal transduction;cell surface receptor signaling pathway;regulation of signaling;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of ERBB signaling pathway;regulation of cell communication;single-organism process;cellular response to stimulus;negative regulation of ERBB signaling pathway;negative regulation of signal transduction;regulation of signal transduction;regulation of biological process;biological regulation;negative regulation of biological process;cellular process;ERBB signaling pathway;transport;regulation of cellular process;biological_process;cell communication;establishment of localization;localization;single organism signaling;endocytosis;vesicle-mediated transport;response to stimulus;single-organism cellular process;negative regulation of cellular process;negative regulation of cell communication; 9;3;6;3;6;6;3;2;4;5;3;7;5;4;2;3;5;4;4;2;2;2;2;8;4;3;1;4;3;2;3;6;5;2;3;3;4; GO:0005905;GO:0030118;GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0016020;GO:0098589;GO:0044425;GO:0098797;GO:0044459;GO:0032991;GO:0030117;GO:0030132;GO:0012505;GO:0005886;GO:0043231;GO:0043234;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0098796;GO:0044444;GO:0048475;GO:0044424;GO:0098805; coated pit;clathrin coat;intracellular organelle;cell periphery;membrane-bounded organelle;organelle;cytoplasm;nucleus;membrane;membrane region;membrane part;plasma membrane protein complex;plasma membrane part;macromolecular complex;membrane coat;clathrin coat of coated pit;endomembrane system;plasma membrane;intracellular membrane-bounded organelle;protein complex;cell part;cell;intracellular;cellular_component;membrane protein complex;cytoplasmic part;coated membrane;intracellular part;whole membrane; 3;5;3;3;3;2;4;5;2;3;2;4;3;2;4;4;3;3;4;3;2;2;3;1;3;4;3;3;3; GO:0003674;GO:0043169;GO:0043167;GO:0005509;GO:0046872;GO:0005488; molecular_function;cation binding;ion binding;calcium ion binding;metal ion binding;binding; 1;4;3;6;5;2; K12472 map04144; Endocytosis; IPR011992;IPR018247;IPR002048;IPR000261; EF-hand domain pair;EF-Hand 1, calcium-binding site;EF-hand domain;EH domain; nucleus Hs10864047 1732.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q9NP80 Calcium-independent phospholipase A2-gamma OS=Homo sapiens OX=9606 GN=PNPLA8 PE=1 SV=1 - [PLPL8_HUMAN] 0.812 0.975 1.437 0.871 0.921 1.261 0.832820513 nan 0.945711183 nan 1.473846154 nan 1.369163952 nan GO:0006820;GO:0046338;GO:0044281;GO:0044282;GO:0044283;GO:0046434;GO:0044712;GO:0044710;GO:0033036;GO:0046503;GO:0015718;GO:0015849;GO:0015711;GO:0032787;GO:0001516;GO:0046337;GO:0043436;GO:0046486;GO:0010876;GO:1901565;GO:1901564;GO:0006576;GO:0016053;GO:1901568;GO:0019637;GO:0033559;GO:0032309;GO:0046717;GO:0006807;GO:0015908;GO:1901576;GO:1901575;GO:1901571;GO:1901570;GO:0097164;GO:0016042;GO:0015909;GO:0006629;GO:0009308;GO:0006811;GO:0006810;GO:0044711;GO:0008150;GO:0008152;GO:0001676;GO:0051234;GO:0090407;GO:0046903;GO:0008654;GO:0046394;GO:0044765;GO:0006690;GO:0006692;GO:0042439;GO:1901616;GO:1901615;GO:0006633;GO:0006631;GO:0043651;GO:0006636;GO:0006869;GO:0044248;GO:0034641;GO:0044242;GO:0044699;GO:0046942;GO:0006644;GO:0009987;GO:0044106;GO:0044255;GO:0034638;GO:0006082;GO:0071715;GO:0006066;GO:0046475;GO:0046474;GO:0046470;GO:0006650;GO:0019752;GO:0008219;GO:1903963;GO:0046457;GO:0006693;GO:0072330;GO:0071704;GO:0071702;GO:0046164;GO:0045017;GO:0009395;GO:0009058;GO:0044763;GO:0009056;GO:0051179;GO:1902578;GO:0008610;GO:0044238;GO:0036151;GO:0036152;GO:0050482;GO:0044237;GO:0046456;GO:0006796;GO:0019369;GO:0006793;GO:0044249; anion transport;phosphatidylethanolamine catabolic process;small molecule metabolic process;small molecule catabolic process;small molecule biosynthetic process;organophosphate catabolic process;single-organism catabolic process;single-organism metabolic process;macromolecule localization;glycerolipid catabolic process;monocarboxylic acid transport;organic acid transport;organic anion transport;monocarboxylic acid metabolic process;prostaglandin biosynthetic process;phosphatidylethanolamine metabolic process;oxoacid metabolic process;glycerolipid metabolic process;lipid localization;organonitrogen compound catabolic process;organonitrogen compound metabolic process;cellular biogenic amine metabolic process;organic acid biosynthetic process;fatty acid derivative metabolic process;organophosphate metabolic process;unsaturated fatty acid metabolic process;icosanoid secretion;acid secretion;nitrogen compound metabolic process;fatty acid transport;organic substance biosynthetic process;organic substance catabolic process;fatty acid derivative transport;fatty acid derivative biosynthetic process;ammonium ion metabolic process;lipid catabolic process;long-chain fatty acid transport;lipid metabolic process;amine metabolic process;ion transport;transport;single-organism biosynthetic process;biological_process;metabolic process;long-chain fatty acid metabolic process;establishment of localization;organophosphate biosynthetic process;secretion;phospholipid biosynthetic process;carboxylic acid biosynthetic process;single-organism transport;icosanoid metabolic process;prostanoid metabolic process;ethanolamine-containing compound metabolic process;organic hydroxy compound catabolic process;organic hydroxy compound metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;linoleic acid metabolic process;unsaturated fatty acid biosynthetic process;lipid transport;cellular catabolic process;cellular nitrogen compound metabolic process;cellular lipid catabolic process;single-organism process;carboxylic acid transport;phospholipid metabolic process;cellular process;cellular amine metabolic process;cellular lipid metabolic process;phosphatidylcholine catabolic process;organic acid metabolic process;icosanoid transport;alcohol metabolic process;glycerophospholipid catabolic process;glycerophospholipid biosynthetic process;phosphatidylcholine metabolic process;glycerophospholipid metabolic process;carboxylic acid metabolic process;cell death;arachidonate transport;prostanoid biosynthetic process;prostaglandin metabolic process;monocarboxylic acid biosynthetic process;organic substance metabolic process;organic substance transport;alcohol catabolic process;glycerolipid biosynthetic process;phospholipid catabolic process;biosynthetic process;single-organism cellular process;catabolic process;localization;single-organism localization;lipid biosynthetic process;primary metabolic process;phosphatidylcholine acyl-chain remodeling;phosphatidylethanolamine acyl-chain remodeling;arachidonic acid secretion;cellular metabolic process;icosanoid biosynthetic process;phosphate-containing compound metabolic process;arachidonic acid metabolic process;phosphorus metabolic process;cellular biosynthetic process; 6;8;4;5;5;5;4;3;3;6;7;5;6;7;8;7;5;5;4;5;4;6;5;4;4;6;7;6;3;6;4;4;5;5;4;5;7;4;5;5;4;4;1;2;6;3;5;5;5;6;4;5;6;4;5;4;6;5;7;7;5;4;4;5;2;6;5;2;5;4;6;4;6;5;7;6;5;6;6;4;7;7;7;7;3;5;6;5;6;3;3;3;2;3;5;3;6;6;8;3;6;5;6;4;4; GO:0005783;GO:0005789;GO:0005778;GO:0016021;GO:0016020;GO:0005777;GO:0031903;GO:0005794;GO:0098588;GO:0048471;GO:0043231;GO:0042175;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0031224;GO:0044439;GO:0044438;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0042579;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0044424;GO:0098805;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;peroxisomal membrane;integral component of membrane;membrane;peroxisome;microbody membrane;Golgi apparatus;bounding membrane of organelle;perinuclear region of cytoplasm;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;intrinsic component of membrane;peroxisomal part;microbody part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;microbody;cytoplasm;organelle membrane;cell part;cell;intracellular;intracellular part;whole membrane;cellular_component; 4;3;5;4;2;6;4;4;4;5;4;3;2;2;3;3;2;4;4;3;5;4;3;5;3;4;5;4;3;2;2;3;3;3;1; GO:1901363;GO:0000166;GO:0097367;GO:0004620;GO:0016298;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0016788;GO:0003824;GO:0004623;GO:0047499;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0052689;GO:0030554;GO:0001883;GO:0001882;GO:0036094;GO:0004622;GO:0043168; heterocyclic compound binding;nucleotide binding;carbohydrate derivative binding;phospholipase activity;lipase activity;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;phospholipase A2 activity;calcium-independent phospholipase A2 activity;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;carboxylic ester hydrolase activity;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;small molecule binding;lysophospholipase activity;anion binding; 3;4;3;6;5;1;2;4;5;5;6;3;4;2;6;7;3;6;5;6;4;5;3;5;6;5;4;3;6;4; K16815 IPR002641;IPR016035; Patatin-like phospholipase domain;Acyl transferase/acyl hydrolase/lysophospholipase; mitochondria Hs14752266 1627.0 I [I] Lipid transport and metabolism; Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=3 - [USP9X_HUMAN] 0.713 0.723 1.686 1.318 0.628 1.311 0.986168741 0.631745907 2.098726115 1.89E-07 2.331950207 4.95E-07 2.087579618 5.15E-06 GO:0048675;GO:0080090;GO:0048589;GO:0048588;GO:0051603;GO:0048468;GO:0007292;GO:0030509;GO:0007165;GO:0007166;GO:0007167;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0019222;GO:0071704;GO:0048869;GO:0070647;GO:0070848;GO:0048519;GO:0007178;GO:1990138;GO:0010467;GO:0060255;GO:0030163;GO:2001141;GO:0010033;GO:0007179;GO:0051704;GO:0044700;GO:0044703;GO:0044702;GO:0044707;GO:0048870;GO:0019538;GO:0071559;GO:0019438;GO:0051252;GO:0009892;GO:0070887;GO:0009890;GO:0006928;GO:0010629;GO:0006807;GO:0001764;GO:0031175;GO:0007067;GO:0050789;GO:0097659;GO:0045934;GO:1901576;GO:1901575;GO:0000904;GO:0016049;GO:0000902;GO:0044260;GO:0046483;GO:0016043;GO:0065007;GO:0071840;GO:0006367;GO:0006366;GO:0016477;GO:0016579;GO:0018130;GO:0061564;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0007059;GO:0000003;GO:0016070;GO:1902679;GO:0044271;GO:0050896;GO:0006355;GO:0048812;GO:0006351;GO:0006352;GO:0006511;GO:0010558;GO:0071772;GO:0071773;GO:0032774;GO:0044265;GO:0030154;GO:0019953;GO:0070646;GO:0044248;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007154;GO:0009653;GO:0044699;GO:0009719;GO:0006139;GO:0000122;GO:0000280;GO:0009057;GO:0031327;GO:0006508;GO:0060560;GO:0032502;GO:0006996;GO:0032501;GO:0048609;GO:0032504;GO:0010556;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0007409;GO:0044257;GO:0032990;GO:0007049;GO:0071363;GO:0051253;GO:0043170;GO:0071560;GO:0051674;GO:0048731;GO:0071495;GO:0030030;GO:0031326;GO:0031324;GO:0031323;GO:1903047;GO:0090304;GO:0022402;GO:0043632;GO:0007275;GO:0007276;GO:0040007;GO:2000112;GO:2000113;GO:0032989;GO:0071310;GO:0006357;GO:0051301;GO:0010468;GO:0048666;GO:0048667;GO:0000278;GO:0030182;GO:0044267;GO:0019219;GO:0019941;GO:0006464;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0042221;GO:0022008;GO:0009056;GO:0051179;GO:0040011;GO:0044238;GO:0048699;GO:0048858;GO:0007399;GO:0048856;GO:0044237;GO:1902589;GO:0048285;GO:0048523; axon extension;regulation of primary metabolic process;developmental growth;developmental cell growth;proteolysis involved in cellular protein catabolic process;cell development;female gamete generation;BMP signaling pathway;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;regulation of metabolic process;organic substance metabolic process;cellular developmental process;protein modification by small protein conjugation or removal;response to growth factor;negative regulation of biological process;transmembrane receptor protein serine/threonine kinase signaling pathway;neuron projection extension;gene expression;regulation of macromolecule metabolic process;protein catabolic process;regulation of RNA biosynthetic process;response to organic substance;transforming growth factor beta receptor signaling pathway;multi-organism process;single organism signaling;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;cell motility;protein metabolic process;response to transforming growth factor beta;aromatic compound biosynthetic process;regulation of RNA metabolic process;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of biosynthetic process;movement of cell or subcellular component;negative regulation of gene expression;nitrogen compound metabolic process;neuron migration;neuron projection development;mitotic nuclear division;regulation of biological process;nucleic acid-templated transcription;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;organic substance catabolic process;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;cellular macromolecule metabolic process;heterocycle metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;transcription initiation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;cell migration;protein deubiquitination;heterocycle biosynthetic process;axon development;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;chromosome segregation;reproduction;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;neuron projection morphogenesis;transcription, DNA-templated;DNA-templated transcription, initiation;ubiquitin-dependent protein catabolic process;negative regulation of macromolecule biosynthetic process;response to BMP;cellular response to BMP stimulus;RNA biosynthetic process;cellular macromolecule catabolic process;cell differentiation;sexual reproduction;protein modification by small protein removal;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;anatomical structure morphogenesis;single-organism process;response to endogenous stimulus;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;nuclear division;macromolecule catabolic process;negative regulation of cellular biosynthetic process;proteolysis;developmental growth involved in morphogenesis;developmental process;organelle organization;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;regulation of macromolecule biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;axonogenesis;cellular protein catabolic process;cell part morphogenesis;cell cycle;cellular response to growth factor stimulus;negative regulation of RNA metabolic process;macromolecule metabolic process;cellular response to transforming growth factor beta stimulus;localization of cell;system development;cellular response to endogenous stimulus;cell projection organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;cell cycle process;modification-dependent macromolecule catabolic process;multicellular organism development;gamete generation;growth;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;cellular component morphogenesis;cellular response to organic substance;regulation of transcription from RNA polymerase II promoter;cell division;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;mitotic cell cycle;neuron differentiation;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;modification-dependent protein catabolic process;cellular protein modification process;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;response to chemical;neurogenesis;catabolic process;localization;locomotion;primary metabolic process;generation of neurons;cell projection morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;single-organism organelle organization;organelle fission;negative regulation of cellular process; 6;4;3;4;6;4;5;6;4;5;6;5;4;3;4;3;3;4;7;5;2;7;5;5;4;5;6;4;6;2;3;3;3;3;3;4;4;5;5;3;4;4;4;5;3;5;5;5;2;7;5;4;4;5;3;5;4;4;3;2;2;8;7;4;7;5;6;4;3;5;5;1;2;5;4;2;5;6;5;2;6;6;6;7;8;5;4;5;6;5;5;3;6;4;4;4;2;5;4;3;2;3;4;7;6;5;5;5;4;2;4;2;3;3;5;2;4;7;7;6;7;6;5;4;6;5;4;5;3;4;4;4;5;4;4;5;5;4;6;4;4;2;6;6;4;5;7;4;5;5;6;5;6;5;5;7;6;3;2;3;5;3;4;4;3;6;3;2;2;3;7;5;5;3;3;4;5;3; GO:0030426;GO:0016020;GO:0030427;GO:0042995;GO:0005829;GO:0044424;GO:0005622;GO:0044444;GO:0043005;GO:0044463;GO:0044464;GO:0005623;GO:0097458;GO:0005737;GO:0005575; growth cone;membrane;site of polarized growth;cell projection;cytosol;intracellular part;intracellular;cytoplasmic part;neuron projection;cell projection part;cell part;cell;neuron part;cytoplasm;cellular_component; 4;2;3;3;5;3;3;4;4;3;2;2;3;4;1; GO:0101005;GO:0046332;GO:0005488;GO:0004843;GO:0004197;GO:0016787;GO:0003824;GO:0036459;GO:0008233;GO:0008234;GO:0019783;GO:0005515;GO:0003674;GO:0004175;GO:0070410;GO:0070011; ubiquitinyl hydrolase activity;SMAD binding;binding;thiol-dependent ubiquitin-specific protease activity;cysteine-type endopeptidase activity;hydrolase activity;catalytic activity;thiol-dependent ubiquitinyl hydrolase activity;peptidase activity;cysteine-type peptidase activity;ubiquitin-like protein-specific protease activity;protein binding;molecular_function;endopeptidase activity;co-SMAD binding;peptidase activity, acting on L-amino acid peptides; 4;4;2;6;7;3;2;5;4;6;7;3;1;6;5;5; K11840 IPR018200;IPR016024;IPR011989;IPR001394;IPR028889; Ubiquitin specific protease, conserved site;Armadillo-type fold;Armadillo-like helical;Peptidase C19, ubiquitin carboxyl-terminal hydrolase;Ubiquitin specific protease domain; plasma membrane Hs11641425 5323.0 O [O] Posttranslational modification, protein turnover, chaperones; P02652 Apolipoprotein A-II OS=Homo sapiens OX=9606 GN=APOA2 PE=1 SV=1 - [APOA2_HUMAN] 1.049 1.214 0.734 1.028 1.293 0.62 0.864085667 2.24E-31 0.795050271 5.53E-56 0.60461285 3.06E-101 0.479505027 0.723456361 GO:0006869;GO:0044699;GO:0044267;GO:0044710;GO:0044260;GO:0018193;GO:0071704;GO:1902578;GO:0071702;GO:0033036;GO:0018158;GO:0006810;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0010876;GO:0051179;GO:0055114;GO:0044238;GO:0019538;GO:0018206;GO:0044765;GO:0044237;GO:0043170;GO:0044763;GO:0042157; lipid transport;single-organism process;cellular protein metabolic process;single-organism metabolic process;cellular macromolecule metabolic process;peptidyl-amino acid modification;organic substance metabolic process;single-organism localization;organic substance transport;macromolecule localization;protein oxidation;transport;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;lipid localization;localization;oxidation-reduction process;primary metabolic process;protein metabolic process;peptidyl-methionine modification;single-organism transport;cellular metabolic process;macromolecule metabolic process;single-organism cellular process;lipoprotein metabolic process; 5;2;5;3;4;7;3;3;5;3;4;4;2;6;5;5;1;2;3;4;2;4;3;4;8;4;3;4;3;5; GO:0034358;GO:1990777;GO:0005615;GO:0034364;GO:0032994;GO:0032991;GO:0005575;GO:0005576;GO:0044421; plasma lipoprotein particle;lipoprotein particle;extracellular space;high-density lipoprotein particle;protein-lipid complex;macromolecular complex;cellular_component;extracellular region;extracellular region part; 3;4;3;4;3;2;1;2;2; GO:0003674;GO:0005488;GO:0008289; molecular_function;binding;lipid binding; 1;2;3; K08758 map03320; PPAR signaling pathway; IPR006801; Apolipoprotein A-II (ApoA-II); extracellular Q9UHV7 Mediator of RNA polymerase II transcription subunit 13 OS=Homo sapiens OX=9606 GN=MED13 PE=1 SV=3 - [MED13_HUMAN] 1.173 0.926 1.068 1.217 0.904 0.705 1.266738661 nan 1.346238938 nan 1.153347732 nan 0.779867257 nan GO:0080090;GO:0019222;GO:0048585;GO:0030518;GO:0048583;GO:0007165;GO:1901362;GO:1901360;GO:0009755;GO:0051716;GO:0010605;GO:0010604;GO:0009968;GO:0009966;GO:0010033;GO:0044092;GO:0048518;GO:0048519;GO:0006367;GO:0060255;GO:0042221;GO:2001141;GO:0043433;GO:0046483;GO:0044700;GO:0044249;GO:0048878;GO:0071407;GO:0019438;GO:0009892;GO:0070887;GO:0009890;GO:0009891;GO:0051254;GO:0010629;GO:0006807;GO:0045935;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0014070;GO:0006366;GO:0065009;GO:0065008;GO:0018130;GO:2000272;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0042632;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0043401;GO:0006357;GO:0006351;GO:0006352;GO:0010558;GO:0032774;GO:0071310;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0055088;GO:0044699;GO:0009893;GO:0009719;GO:0006139;GO:0000122;GO:0010557;GO:0031325;GO:0071495;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0032870;GO:0045892;GO:0045893;GO:0042592;GO:0051090;GO:0009725;GO:0051253;GO:0051252;GO:0043170;GO:1902680;GO:0010628;GO:0045944;GO:0048545;GO:1903508;GO:0031328;GO:0031327;GO:0031326;GO:0071383;GO:0031324;GO:0031323;GO:0090304;GO:0055092;GO:0055090;GO:0030522;GO:0030521;GO:0033993;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0010556;GO:0010469;GO:0010468;GO:0070328;GO:0045934;GO:0019219;GO:0071396;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0007154;GO:0044238;GO:1904168;GO:1904167;GO:0044237;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;intracellular steroid hormone receptor signaling pathway;regulation of response to stimulus;signal transduction;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;hormone-mediated signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;response to organic substance;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;transcription initiation from RNA polymerase II promoter;regulation of macromolecule metabolic process;response to chemical;regulation of RNA biosynthetic process;negative regulation of sequence-specific DNA binding transcription factor activity;heterocycle metabolic process;single organism signaling;cellular biosynthetic process;chemical homeostasis;cellular response to organic cyclic compound;aromatic compound biosynthetic process;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;negative regulation of gene expression;nitrogen compound metabolic process;positive regulation of nucleobase-containing compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;response to organic cyclic compound;transcription from RNA polymerase II promoter;regulation of molecular function;regulation of biological quality;heterocycle biosynthetic process;negative regulation of receptor activity;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;cholesterol homeostasis;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;steroid hormone mediated signaling pathway;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;DNA-templated transcription, initiation;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular response to organic substance;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;lipid homeostasis;single-organism process;positive regulation of metabolic process;response to endogenous stimulus;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of macromolecule biosynthetic process;positive regulation of cellular metabolic process;cellular response to endogenous stimulus;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to hormone stimulus;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;homeostatic process;regulation of sequence-specific DNA binding transcription factor activity;response to hormone;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;response to steroid hormone;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;cellular response to steroid hormone stimulus;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;sterol homeostasis;acylglycerol homeostasis;intracellular receptor signaling pathway;androgen receptor signaling pathway;response to lipid;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of receptor activity;regulation of gene expression;triglyceride homeostasis;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular response to lipid;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;primary metabolic process;negative regulation of thyroid hormone receptor activity;regulation of thyroid hormone receptor activity;cellular metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;6;3;4;5;4;5;3;4;4;4;4;4;4;2;2;8;4;3;6;5;4;3;4;5;6;5;3;4;4;4;5;5;3;5;2;7;4;4;2;5;7;3;3;5;5;4;3;1;2;5;8;5;5;2;6;6;7;6;7;5;6;5;3;4;2;4;5;3;4;6;2;3;3;4;7;5;4;4;2;4;7;7;5;6;6;4;4;4;5;5;4;6;5;7;5;7;5;5;5;6;4;4;5;7;7;5;7;5;6;6;3;5;5;4;5;8;5;5;6;6;3;5;3;4;4;4;4;3;5;5;3;3;3; GO:0031974;GO:0016592;GO:0016020;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0005622;GO:0043227;GO:0005654;GO:0031981;GO:0044446;GO:0005634;GO:0044451;GO:0044464;GO:0043229;GO:0005623;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;mediator complex;membrane;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular;membrane-bounded organelle;nucleoplasm;nuclear lumen;intracellular organelle part;nucleus;nucleoplasm part;cell part;intracellular organelle;cell;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;4;2;3;4;3;4;3;2;3;3;5;5;3;5;5;2;3;2;2;2;1;4; GO:0060089;GO:0001076;GO:0003713;GO:0003712;GO:0000988;GO:0046966;GO:0003674;GO:0005488;GO:0000989;GO:0035257;GO:0030374;GO:0042809;GO:0008134;GO:0001104;GO:0051427;GO:0005515;GO:0005102;GO:0004872; molecular transducer activity;transcription factor activity, RNA polymerase II transcription factor binding;transcription coactivator activity;transcription cofactor activity;transcription factor activity, protein binding;thyroid hormone receptor binding;molecular_function;binding;transcription factor activity, transcription factor binding;nuclear hormone receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;vitamin D receptor binding;transcription factor binding;RNA polymerase II transcription cofactor activity;hormone receptor binding;protein binding;receptor binding;receptor activity; 2;4;5;4;2;5;1;2;3;6;6;5;4;5;5;3;4;3; K15164 map04919; Thyroid hormone signaling pathway; IPR009401;IPR021643; Mediator complex, subunit Med13;Mediator complex, subunit Med13, N-terminal, metazoa/fungi; cytosol Hs4827044 4427.0 K [K] Transcription; Q8IYB3 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2 - [SRRM1_HUMAN] 0.902 0.603 2.008 0.515 0.966 0.439 1.495854063 0.270454203 0.533126294 0.00501242 3.330016584 0.003394826 0.454451346 0.035588964 GO:0051169;GO:0051168;GO:1901362;GO:1901360;GO:0033036;GO:0046483;GO:0000398;GO:0006405;GO:0019438;GO:0006807;GO:0051028;GO:0097659;GO:1901576;GO:0044260;GO:0006366;GO:0006369;GO:0018130;GO:0006810;GO:0008150;GO:0008152;GO:0034654;GO:0051236;GO:0051234;GO:0016070;GO:0016071;GO:0050658;GO:0044271;GO:0046907;GO:0044765;GO:0000377;GO:0006351;GO:0006353;GO:0015931;GO:0071166;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0008380;GO:0009987;GO:0006725;GO:0043170;GO:0050657;GO:0090304;GO:0071705;GO:0071704;GO:0010467;GO:0071702;GO:0006403;GO:0006406;GO:0031124;GO:0006913;GO:0031123;GO:0000375;GO:0009058;GO:0009059;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0071426;GO:0071427;GO:0044237;GO:0006396;GO:1902582;GO:0006397; nuclear transport;nuclear export;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;macromolecule localization;heterocycle metabolic process;mRNA splicing, via spliceosome;RNA export from nucleus;aromatic compound biosynthetic process;nitrogen compound metabolic process;mRNA transport;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;transcription from RNA polymerase II promoter;termination of RNA polymerase II transcription;heterocycle biosynthetic process;transport;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;establishment of RNA localization;establishment of localization;RNA metabolic process;mRNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;intracellular transport;single-organism transport;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;transcription, DNA-templated;DNA-templated transcription, termination;nucleobase-containing compound transport;ribonucleoprotein complex localization;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;RNA splicing;cellular process;cellular aromatic compound metabolic process;macromolecule metabolic process;nucleic acid transport;nucleic acid metabolic process;nitrogen compound transport;organic substance metabolic process;gene expression;organic substance transport;RNA localization;mRNA export from nucleus;mRNA 3'-end processing;nucleocytoplasmic transport;RNA 3'-end processing;RNA splicing, via transesterification reactions;biosynthetic process;macromolecule biosynthetic process;establishment of localization in cell;localization;single-organism localization;cellular localization;primary metabolic process;ribonucleoprotein complex export from nucleus;mRNA-containing ribonucleoprotein complex export from nucleus;cellular metabolic process;RNA processing;single-organism intracellular transport;mRNA processing; 6;8;5;4;3;4;8;6;5;3;6;7;4;4;7;8;5;4;1;2;5;4;3;5;6;5;5;5;4;9;6;7;6;4;6;4;4;5;2;4;7;2;4;4;7;5;5;3;5;5;4;6;8;7;7;8;3;5;4;2;3;3;3;5;6;3;6;5;7; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0044464;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0005654;GO:0016363;GO:0034399;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044451;GO:1990904;GO:0005623;GO:0030529;GO:0071013;GO:0032991;GO:0005575;GO:0070013;GO:0005681; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;cell part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;nucleoplasm;nuclear matrix;nuclear periphery;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nucleoplasm part;ribonucleoprotein complex;cell;intracellular ribonucleoprotein complex;catalytic step 2 spliceosome;macromolecular complex;cellular_component;intracellular organelle lumen;spliceosomal complex; 2;5;4;3;5;4;3;2;2;3;3;3;2;7;6;5;5;5;3;4;4;5;5;3;2;4;6;2;1;4;5; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0044822;GO:0003723; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;poly(A) RNA binding;RNA binding; 3;1;2;4;5;3;6;5; K13171 map03013;map03015; RNA transport;mRNA surveillance pathway; IPR002483; PWI domain; nucleus Hs5032119 437.0 AR [A] RNA processing and modification;[R] General function prediction only; Q76NI1 Kinase non-catalytic C-lobe domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KNDC1 PE=2 SV=2 - [KNDC1_HUMAN] 0.952 1.178 1.22 0.718 0.979 1.192 0.808149406 nan 0.73340143 nan 1.03565365 nan 1.217568948 nan GO:0019220;GO:0080090;GO:0019222;GO:0048468;GO:0016358;GO:0060322;GO:0007165;GO:0031344;GO:0071840;GO:0051716;GO:0010604;GO:0071704;GO:0048869;GO:0045664;GO:0048513;GO:0021696;GO:0021697;GO:0021695;GO:0042325;GO:0060255;GO:0010975;GO:0044700;GO:0042327;GO:0044707;GO:0019538;GO:0021684;GO:0021681;GO:0021683;GO:0022604;GO:0021533;GO:0009893;GO:0022603;GO:0031175;GO:0035556;GO:0021707;GO:0050789;GO:0044267;GO:0000904;GO:0000902;GO:0044260;GO:0016043;GO:0065007;GO:0048646;GO:0050793;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0051239;GO:0021549;GO:0051174;GO:0007420;GO:0050896;GO:0031401;GO:0048813;GO:0051960;GO:0048814;GO:0008152;GO:0016310;GO:0030154;GO:0051128;GO:0023052;GO:0009653;GO:0044699;GO:0007417;GO:0050767;GO:0010562;GO:0051246;GO:0051247;GO:0060284;GO:0010769;GO:0032270;GO:0031399;GO:0021953;GO:0032502;GO:0032501;GO:0044238;GO:0022037;GO:0009987;GO:0048518;GO:0045595;GO:0032990;GO:0032268;GO:0050773;GO:0048731;GO:0030030;GO:0031325;GO:0031323;GO:0021575;GO:0043170;GO:0045937;GO:0007275;GO:0032989;GO:0048812;GO:0048666;GO:0048667;GO:0006468;GO:0030182;GO:0006464;GO:0044767;GO:0044763;GO:0007154;GO:0022008;GO:0007264;GO:0021587;GO:0048699;GO:0048858;GO:0007399;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:0030902;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;cell development;dendrite development;head development;signal transduction;regulation of cell projection organization;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of macromolecule metabolic process;organic substance metabolic process;cellular developmental process;regulation of neuron differentiation;animal organ development;cerebellar cortex morphogenesis;cerebellar cortex formation;cerebellar cortex development;regulation of phosphorylation;regulation of macromolecule metabolic process;regulation of neuron projection development;single organism signaling;positive regulation of phosphorylation;single-multicellular organism process;protein metabolic process;cerebellar granular layer formation;cerebellar granular layer development;cerebellar granular layer morphogenesis;regulation of cell morphogenesis;cell differentiation in hindbrain;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;neuron projection development;intracellular signal transduction;cerebellar granule cell differentiation;regulation of biological process;cellular protein metabolic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;biological regulation;anatomical structure formation involved in morphogenesis;regulation of developmental process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;regulation of multicellular organismal process;cerebellum development;regulation of phosphorus metabolic process;brain development;response to stimulus;positive regulation of protein modification process;dendrite morphogenesis;regulation of nervous system development;regulation of dendrite morphogenesis;metabolic process;phosphorylation;cell differentiation;regulation of cellular component organization;signaling;anatomical structure morphogenesis;single-organism process;central nervous system development;regulation of neurogenesis;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell development;regulation of cell morphogenesis involved in differentiation;positive regulation of cellular protein metabolic process;regulation of protein modification process;central nervous system neuron differentiation;developmental process;multicellular organismal process;primary metabolic process;metencephalon development;cellular process;positive regulation of biological process;regulation of cell differentiation;cell part morphogenesis;regulation of cellular protein metabolic process;regulation of dendrite development;system development;cell projection organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;hindbrain morphogenesis;macromolecule metabolic process;positive regulation of phosphate metabolic process;multicellular organism development;cellular component morphogenesis;neuron projection morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;neuron differentiation;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell communication;neurogenesis;small GTPase mediated signal transduction;cerebellum morphogenesis;generation of neurons;cell projection morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;hindbrain development;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;4;3;4;4;4;4;5;2;3;4;3;4;7;4;4;4;4;7;4;6;3;7;3;4;4;4;4;5;5;3;4;5;5;5;2;5;5;5;4;3;2;3;3;3;5;5;1;3;4;5;4;2;6;5;5;6;2;6;5;4;2;3;2;5;6;5;5;5;5;6;5;6;6;2;2;3;4;2;2;4;5;5;5;4;4;4;4;4;4;6;4;4;6;5;6;7;6;6;3;3;4;6;6;4;7;5;5;3;3;5;4;4;4;7;7;3; GO:0030425;GO:0044297;GO:0036477;GO:0042995;GO:0043234;GO:0044424;GO:0043025;GO:0043005;GO:0044464;GO:0005623;GO:0005622;GO:0032045;GO:0097458;GO:0032991;GO:0005575; dendrite;cell body;somatodendritic compartment;cell projection;protein complex;intracellular part;neuronal cell body;neuron projection;cell part;cell;intracellular;guanyl-nucleotide exchange factor complex;neuron part;macromolecular complex;cellular_component; 5;3;4;3;3;3;4;4;2;2;3;4;3;2;1; GO:0098772;GO:0005088;GO:0005085;GO:0003674; molecular function regulator;Ras guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;molecular_function; 2;4;3;1; IPR023578;IPR011019;IPR011009;IPR000651;IPR029899;IPR001895; Ras guanine nucleotide exchange factor domain;KIND domain;Protein kinase-like domain;Ras-like guanine nucleotide exchange factor, N-terminal;Protein very KIND;Ras guanine-nucleotide exchange factors catalytic domain; nucleus Q15652 Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2 - [JHD2C_HUMAN] 1.115 1.004 0.909 1.158 1.063 0.947 1.110557769 nan 1.089369708 nan 0.905378486 nan 0.890874882 nan GO:0007599;GO:0080090;GO:0019222;GO:0007596;GO:1901362;GO:1901360;GO:0009611;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0019438;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0065008;GO:0018130;GO:0009889;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032501;GO:0050878;GO:0009987;GO:0006725;GO:1903506;GO:0051252;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0006325;GO:2000112;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0016568;GO:0006996;GO:0044238;GO:0051276;GO:0044237; hemostasis;regulation of primary metabolic process;regulation of metabolic process;blood coagulation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;response to wounding;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;regulation of biological quality;heterocycle biosynthetic process;regulation of biosynthetic process;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;multicellular organismal process;regulation of body fluid levels;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of RNA metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;chromatin modification;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process; 5;4;3;5;5;4;4;4;6;4;3;5;3;4;2;7;4;4;3;2;2;3;5;4;5;3;3;4;1;2;5;5;5;2;6;5;6;6;4;4;5;2;4;2;4;2;4;7;5;4;5;4;5;5;6;3;5;5;5;3;5;4;6;4;3;5;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;5;3;5;2;2;3;2;1;4; GO:0046872;GO:0046966;GO:0003674;GO:0005488;GO:0043169;GO:0035257;GO:0003824;GO:0051213;GO:0016491;GO:0043167;GO:0008134;GO:0051427;GO:0005515;GO:0005102; metal ion binding;thyroid hormone receptor binding;molecular_function;binding;cation binding;nuclear hormone receptor binding;catalytic activity;dioxygenase activity;oxidoreductase activity;ion binding;transcription factor binding;hormone receptor binding;protein binding;receptor binding; 5;5;1;2;4;6;2;4;3;3;4;5;3;4; K11449 map05202; Transcriptional misregulation in cancer; IPR003347; JmjC domain; nucleus Hs20473134 2781.0 K [K] Transcription; Q6ZRG5 Putative uncharacterized protein FLJ43944 OS=Homo sapiens OX=9606 PE=5 SV=1 - [YQ015_HUMAN] 0.61 0.627 2.309 0.997 0.581 0.342 0.972886762 nan 1.716006885 nan 3.68261563 nan 0.588640275 nan IPR032754; Leucine-rich repeat-containing protein 37, N-terminal; nucleus Q8IWU4 Zinc transporter 8 OS=Homo sapiens OX=9606 GN=SLC30A8 PE=1 SV=2 - [ZNT8_HUMAN] 0.801 1.077 1.305 0.857 1.167 0.698 0.743732591 nan 0.734361611 nan 1.211699164 nan 0.598114824 nan GO:0090087;GO:0032024;GO:0008104;GO:0051046;GO:0051047;GO:0051049;GO:0032844;GO:0055076;GO:0010043;GO:0006829;GO:0046879;GO:0048518;GO:0098662;GO:0019725;GO:0051050;GO:0098660;GO:0045184;GO:0090276;GO:0090277;GO:0010038;GO:0070838;GO:0010035;GO:0010033;GO:0016192;GO:0044700;GO:0034284;GO:0019538;GO:0048878;GO:0002376;GO:1903532;GO:0098771;GO:0032940;GO:0046916;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0030073;GO:0044267;GO:0010646;GO:0050708;GO:0006955;GO:0006882;GO:0065007;GO:0065008;GO:0070201;GO:0034097;GO:0072507;GO:0009306;GO:0006812;GO:0006811;GO:0006810;GO:0050796;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0051238;GO:0051235;GO:0051234;GO:0072503;GO:0046903;GO:0050714;GO:0050896;GO:0050801;GO:0023056;GO:0015833;GO:0023052;GO:1903530;GO:0023051;GO:0010647;GO:1904951;GO:0044699;GO:0032880;GO:0042886;GO:0000041;GO:0071577;GO:0034341;GO:1901700;GO:0006875;GO:0009987;GO:0032119;GO:0006873;GO:0060627;GO:0046883;GO:0030001;GO:0030003;GO:0046887;GO:0055080;GO:0055082;GO:0032879;GO:0055085;GO:0009743;GO:0042221;GO:0033036;GO:0072511;GO:0043170;GO:0060341;GO:1990267;GO:0061088;GO:0042592;GO:0009749;GO:0071705;GO:0071704;GO:0071702;GO:0045087;GO:0023061;GO:0010817;GO:0034220;GO:0044765;GO:0044763;GO:0055065;GO:0007267;GO:0007154;GO:0055069;GO:0051179;GO:1902578;GO:0051641;GO:0009746;GO:0044238;GO:0044260;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:0009914;GO:2000021;GO:0015031;GO:0098655;GO:0070555;GO:0048522; regulation of peptide transport;positive regulation of insulin secretion;protein localization;regulation of secretion;positive regulation of secretion;regulation of transport;regulation of homeostatic process;transition metal ion homeostasis;response to zinc ion;zinc II ion transport;hormone secretion;positive regulation of biological process;inorganic cation transmembrane transport;cellular homeostasis;positive regulation of transport;inorganic ion transmembrane transport;establishment of protein localization;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;response to metal ion;divalent metal ion transport;response to inorganic substance;response to organic substance;vesicle-mediated transport;single organism signaling;response to monosaccharide;protein metabolic process;chemical homeostasis;immune system process;positive regulation of secretion by cell;inorganic ion homeostasis;secretion by cell;cellular transition metal ion homeostasis;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;cellular protein metabolic process;regulation of cell communication;regulation of protein secretion;immune response;cellular zinc ion homeostasis;biological regulation;regulation of biological quality;regulation of establishment of protein localization;response to cytokine;divalent inorganic cation homeostasis;protein secretion;cation transport;ion transport;transport;regulation of insulin secretion;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;sequestering of metal ion;maintenance of location;establishment of localization;cellular divalent inorganic cation homeostasis;secretion;positive regulation of protein secretion;response to stimulus;ion homeostasis;positive regulation of signaling;peptide transport;signaling;regulation of secretion by cell;regulation of signaling;positive regulation of cell communication;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;amide transport;transition metal ion transport;zinc II ion transmembrane transport;response to interferon-gamma;response to oxygen-containing compound;cellular metal ion homeostasis;cellular process;sequestering of zinc ion;cellular ion homeostasis;regulation of vesicle-mediated transport;regulation of hormone secretion;metal ion transport;cellular cation homeostasis;positive regulation of hormone secretion;cation homeostasis;cellular chemical homeostasis;regulation of localization;transmembrane transport;response to carbohydrate;response to chemical;macromolecule localization;divalent inorganic cation transport;macromolecule metabolic process;regulation of cellular localization;response to transition metal nanoparticle;regulation of sequestering of zinc ion;homeostatic process;response to glucose;nitrogen compound transport;organic substance metabolic process;organic substance transport;innate immune response;signal release;regulation of hormone levels;ion transmembrane transport;single-organism transport;single-organism cellular process;metal ion homeostasis;cell-cell signaling;cell communication;zinc ion homeostasis;localization;single-organism localization;cellular localization;response to hexose;primary metabolic process;cellular macromolecule metabolic process;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;hormone transport;regulation of ion homeostasis;protein transport;cation transmembrane transport;response to interleukin-1;positive regulation of cellular process; 5;6;4;5;4;4;3;9;5;9;6;2;7;4;3;6;4;5;5;5;8;4;4;5;3;6;4;5;2;4;7;4;9;4;5;2;7;6;5;4;6;3;9;2;3;5;5;8;5;6;5;4;6;3;4;3;1;2;4;3;3;8;5;5;2;6;3;6;2;5;3;4;3;2;4;5;8;8;5;4;8;2;5;6;4;4;7;7;4;7;5;3;4;5;3;3;7;4;4;4;4;4;8;5;3;5;4;5;4;5;4;3;8;4;4;9;2;3;3;7;3;4;6;6;5;3;5;4;5;6;6;3; GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0099503;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0030667;GO:0043227;GO:0044433;GO:0031224;GO:0030141;GO:0097708;GO:0044446;GO:0044444;GO:0012505;GO:0012506;GO:0005886;GO:0005737;GO:0031090;GO:0031410;GO:0030658;GO:0030659;GO:0044464;GO:0043229;GO:0005623;GO:0071944;GO:0030133;GO:0098805;GO:0043226;GO:0005622;GO:0005575; vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;secretory vesicle;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;secretory granule membrane;membrane-bounded organelle;cytoplasmic vesicle part;intrinsic component of membrane;secretory granule;intracellular vesicle;intracellular organelle part;cytoplasmic part;endomembrane system;vesicle membrane;plasma membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;transport vesicle membrane;cytoplasmic vesicle membrane;cell part;intracellular organelle;cell;cell periphery;transport vesicle;whole membrane;organelle;intracellular;cellular_component; 4;5;4;2;5;6;4;4;3;2;2;4;3;4;3;4;4;3;4;3;4;3;4;3;5;4;5;2;3;2;3;4;3;2;3;1; GO:0008270;GO:0046873;GO:0046872;GO:0008324;GO:0005385;GO:0003674;GO:0005488;GO:0046914;GO:0046915;GO:0022891;GO:0022890;GO:0022892;GO:0072509;GO:0046983;GO:0043169;GO:0043167;GO:0042802;GO:0042803;GO:0005215;GO:0005515;GO:0015075;GO:0022857; zinc ion binding;metal ion transmembrane transporter activity;metal ion binding;cation transmembrane transporter activity;zinc ion transmembrane transporter activity;molecular_function;binding;transition metal ion binding;transition metal ion transmembrane transporter activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;divalent inorganic cation transmembrane transporter activity;protein dimerization activity;cation binding;ion binding;identical protein binding;protein homodimerization activity;transporter activity;protein binding;ion transmembrane transporter activity;transmembrane transporter activity; 7;8;5;6;9;1;2;6;9;4;7;3;8;4;4;3;4;5;2;3;5;3; K14695 IPR033572;IPR027470;IPR002524; Zinc transporter 8;Cation efflux protein, cytoplasmic domain;Cation efflux protein; plasma membrane Hs20540985 652.0 P [P] Inorganic ion transport and metabolism; P02654 Apolipoprotein C-I OS=Homo sapiens OX=9606 GN=APOC1 PE=1 SV=1 - [APOC1_HUMAN] 1.012 1.21 0.857 1.007 1.192 0.622 0.836363636 9.72E-29 0.844798658 1.08E-19 0.708264463 7.49E-36 0.521812081 2.29E-18 GO:0006633;GO:0019220;GO:0034447;GO:0051049;GO:0043436;GO:0006820;GO:0044281;GO:0044282;GO:0010873;GO:0030100;GO:0071840;GO:0080090;GO:0044712;GO:0044710;GO:0044711;GO:0019222;GO:0033239;GO:0033238;GO:0045834;GO:0008202;GO:0044093;GO:0044092;GO:0048518;GO:0065007;GO:0033036;GO:0016192;GO:0046503;GO:0051055;GO:0051051;GO:0034367;GO:0034368;GO:0034369;GO:0015711;GO:0032787;GO:1902652;GO:0010872;GO:0046486;GO:0051128;GO:0010876;GO:1901565;GO:0044248;GO:1901564;GO:0044707;GO:0044249;GO:0019538;GO:0016053;GO:0048261;GO:0019637;GO:0045717;GO:0034377;GO:0034375;GO:0022607;GO:0009892;GO:0009893;GO:0015918;GO:0015850;GO:0046164;GO:0044283;GO:0034379;GO:0006807;GO:0042157;GO:0010900;GO:1901576;GO:1901575;GO:0051346;GO:0097164;GO:0019216;GO:0016043;GO:0016042;GO:0065003;GO:0097006;GO:0043085;GO:0065005;GO:0065009;GO:0033700;GO:0009395;GO:0006810;GO:0006629;GO:0009308;GO:0006811;GO:0050790;GO:0009889;GO:0050794;GO:0010915;GO:0010916;GO:0008150;GO:0008152;GO:1903725;GO:1903726;GO:0051234;GO:0046434;GO:0051336;GO:0006897;GO:0032368;GO:0032369;GO:0034382;GO:0051241;GO:0034381;GO:0009058;GO:0042439;GO:0010984;GO:0010985;GO:1901616;GO:0006576;GO:1901615;GO:0060192;GO:0006631;GO:0060191;GO:0051239;GO:0006869;GO:0048259;GO:0006639;GO:0006638;GO:0009894;GO:0051129;GO:0030301;GO:0051004;GO:0051005;GO:0034641;GO:0009895;GO:0048519;GO:0044242;GO:0043086;GO:0044699;GO:0071830;GO:0009890;GO:0032375;GO:0032374;GO:0010563;GO:0032371;GO:0010565;GO:0032372;GO:0031327;GO:0045833;GO:0034433;GO:0008610;GO:0015914;GO:0006644;GO:0032501;GO:0031330;GO:0009987;GO:0060627;GO:0044106;GO:0042304;GO:0010899;GO:0044255;GO:0032879;GO:0030258;GO:0034638;GO:0008203;GO:0006082;GO:0043170;GO:0045940;GO:0046394;GO:0006066;GO:0046475;GO:0060696;GO:0046470;GO:0045922;GO:0006898;GO:0006650;GO:0031329;GO:0043933;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0019752;GO:0016125;GO:0046890;GO:0033344;GO:0071825;GO:0071827;GO:1901360;GO:0006641;GO:0050789;GO:0071704;GO:0034434;GO:0034435;GO:0071702;GO:0019217;GO:0045936;GO:0019218;GO:0015748;GO:0051174;GO:0044765;GO:0044763;GO:0051171;GO:0051172;GO:0009056;GO:0051179;GO:1902578;GO:0044238;GO:0042180;GO:0050995;GO:0050994;GO:0044237;GO:0006796;GO:0044085;GO:0006793;GO:0072330;GO:0045806;GO:0048523;GO:0048522; fatty acid biosynthetic process;regulation of phosphate metabolic process;very-low-density lipoprotein particle clearance;regulation of transport;oxoacid metabolic process;anion transport;small molecule metabolic process;small molecule catabolic process;positive regulation of cholesterol esterification;regulation of endocytosis;cellular component organization or biogenesis;regulation of primary metabolic process;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;regulation of metabolic process;negative regulation of cellular amine metabolic process;regulation of cellular amine metabolic process;positive regulation of lipid metabolic process;steroid metabolic process;positive regulation of molecular function;negative regulation of molecular function;positive regulation of biological process;biological regulation;macromolecule localization;vesicle-mediated transport;glycerolipid catabolic process;negative regulation of lipid biosynthetic process;negative regulation of transport;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;organic anion transport;monocarboxylic acid metabolic process;secondary alcohol metabolic process;regulation of cholesterol esterification;glycerolipid metabolic process;regulation of cellular component organization;lipid localization;organonitrogen compound catabolic process;cellular catabolic process;organonitrogen compound metabolic process;single-multicellular organism process;cellular biosynthetic process;protein metabolic process;organic acid biosynthetic process;negative regulation of receptor-mediated endocytosis;organophosphate metabolic process;negative regulation of fatty acid biosynthetic process;plasma lipoprotein particle assembly;high-density lipoprotein particle remodeling;cellular component assembly;negative regulation of metabolic process;positive regulation of metabolic process;sterol transport;organic hydroxy compound transport;alcohol catabolic process;small molecule biosynthetic process;very-low-density lipoprotein particle assembly;nitrogen compound metabolic process;lipoprotein metabolic process;negative regulation of phosphatidylcholine catabolic process;organic substance biosynthetic process;organic substance catabolic process;negative regulation of hydrolase activity;ammonium ion metabolic process;regulation of lipid metabolic process;cellular component organization;lipid catabolic process;macromolecular complex assembly;regulation of plasma lipoprotein particle levels;positive regulation of catalytic activity;protein-lipid complex assembly;regulation of molecular function;phospholipid efflux;phospholipid catabolic process;transport;lipid metabolic process;amine metabolic process;ion transport;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of very-low-density lipoprotein particle clearance;negative regulation of very-low-density lipoprotein particle clearance;biological_process;metabolic process;regulation of phospholipid metabolic process;negative regulation of phospholipid metabolic process;establishment of localization;organophosphate catabolic process;regulation of hydrolase activity;endocytosis;regulation of lipid transport;negative regulation of lipid transport;chylomicron remnant clearance;negative regulation of multicellular organismal process;plasma lipoprotein particle clearance;biosynthetic process;ethanolamine-containing compound metabolic process;regulation of lipoprotein particle clearance;negative regulation of lipoprotein particle clearance;organic hydroxy compound catabolic process;cellular biogenic amine metabolic process;organic hydroxy compound metabolic process;negative regulation of lipase activity;fatty acid metabolic process;regulation of lipase activity;regulation of multicellular organismal process;lipid transport;regulation of receptor-mediated endocytosis;acylglycerol metabolic process;neutral lipid metabolic process;regulation of catabolic process;negative regulation of cellular component organization;cholesterol transport;regulation of lipoprotein lipase activity;negative regulation of lipoprotein lipase activity;cellular nitrogen compound metabolic process;negative regulation of catabolic process;negative regulation of biological process;cellular lipid catabolic process;negative regulation of catalytic activity;single-organism process;triglyceride-rich lipoprotein particle clearance;negative regulation of biosynthetic process;negative regulation of cholesterol transport;regulation of cholesterol transport;negative regulation of phosphorus metabolic process;regulation of sterol transport;regulation of cellular ketone metabolic process;negative regulation of sterol transport;negative regulation of cellular biosynthetic process;negative regulation of lipid metabolic process;steroid esterification;lipid biosynthetic process;phospholipid transport;phospholipid metabolic process;multicellular organismal process;negative regulation of cellular catabolic process;cellular process;regulation of vesicle-mediated transport;cellular amine metabolic process;regulation of fatty acid biosynthetic process;regulation of phosphatidylcholine catabolic process;cellular lipid metabolic process;regulation of localization;lipid modification;phosphatidylcholine catabolic process;cholesterol metabolic process;organic acid metabolic process;macromolecule metabolic process;positive regulation of steroid metabolic process;carboxylic acid biosynthetic process;alcohol metabolic process;glycerophospholipid catabolic process;regulation of phospholipid catabolic process;phosphatidylcholine metabolic process;negative regulation of fatty acid metabolic process;receptor-mediated endocytosis;glycerophospholipid metabolic process;regulation of cellular catabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;sterol metabolic process;regulation of lipid biosynthetic process;cholesterol efflux;protein-lipid complex subunit organization;plasma lipoprotein particle organization;organic cyclic compound metabolic process;triglyceride metabolic process;regulation of biological process;organic substance metabolic process;sterol esterification;cholesterol esterification;organic substance transport;regulation of fatty acid metabolic process;negative regulation of phosphate metabolic process;regulation of steroid metabolic process;organophosphate ester transport;regulation of phosphorus metabolic process;single-organism transport;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;catabolic process;localization;single-organism localization;primary metabolic process;cellular ketone metabolic process;negative regulation of lipid catabolic process;regulation of lipid catabolic process;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process;monocarboxylic acid biosynthetic process;negative regulation of endocytosis;negative regulation of cellular process;positive regulation of cellular process; 6;6;5;4;5;6;4;5;5;5;2;4;4;3;4;3;5;5;4;5;4;4;2;2;3;5;6;5;3;5;6;4;6;7;6;5;5;4;4;5;4;4;3;4;4;5;5;4;6;4;5;4;3;3;6;5;6;5;5;3;5;6;4;4;6;4;5;3;5;5;3;5;6;3;7;6;4;4;5;5;4;4;3;5;5;1;2;6;5;3;5;5;6;5;4;6;3;4;3;4;4;4;5;6;4;7;5;6;3;5;6;6;5;4;4;7;7;8;4;4;2;5;5;2;5;4;6;7;5;6;5;5;5;4;6;5;6;5;2;5;2;4;5;6;6;4;3;5;6;7;4;4;5;6;5;7;6;5;5;7;6;5;4;5;4;4;4;6;6;5;8;5;4;4;7;2;3;7;8;5;6;6;6;5;5;4;3;4;4;3;2;3;3;4;5;5;3;5;3;4;7;4;3;3; GO:0005783;GO:0034361;GO:0034364;GO:0043230;GO:0043231;GO:1990777;GO:0044421;GO:0043229;GO:0043227;GO:0042627;GO:0044424;GO:0012505;GO:0031982;GO:0034385;GO:0044444;GO:0005737;GO:0032994;GO:0034358;GO:0044464;GO:0005623;GO:0005615;GO:0005576;GO:0005622;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0043226; endoplasmic reticulum;very-low-density lipoprotein particle;high-density lipoprotein particle;extracellular organelle;intracellular membrane-bounded organelle;lipoprotein particle;extracellular region part;intracellular organelle;membrane-bounded organelle;chylomicron;intracellular part;endomembrane system;vesicle;triglyceride-rich lipoprotein particle;cytoplasmic part;cytoplasm;protein-lipid complex;plasma lipoprotein particle;cell part;cell;extracellular space;extracellular region;intracellular;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;organelle; 4;5;4;3;4;4;2;3;3;4;3;3;4;4;4;4;3;3;2;2;3;2;3;3;4;2;1;2; GO:0098772;GO:0033293;GO:0005543;GO:0003674;GO:0055102;GO:0004857;GO:0050997;GO:0036094;GO:0031406;GO:0004859;GO:0043167;GO:0043169;GO:0070405;GO:0005504;GO:0008289;GO:0043178;GO:0043177;GO:0005488;GO:0008047;GO:0060228;GO:0030234;GO:0031210;GO:0043168; molecular function regulator;monocarboxylic acid binding;phospholipid binding;molecular_function;lipase inhibitor activity;enzyme inhibitor activity;quaternary ammonium group binding;small molecule binding;carboxylic acid binding;phospholipase inhibitor activity;ion binding;cation binding;ammonium ion binding;fatty acid binding;lipid binding;alcohol binding;organic acid binding;binding;enzyme activator activity;phosphatidylcholine-sterol O-acyltransferase activator activity;enzyme regulator activity;phosphatidylcholine binding;anion binding; 2;6;4;1;5;4;3;3;5;6;3;4;5;4;3;4;4;2;4;5;3;4;4; K22286 IPR006781; Apolipoprotein C-I; extracellular Q9BQC3 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1 - [DPH2_HUMAN] 1.323 1.221 0.702 1.391 0.962 nan 1.083538084 nan 1.445945946 nan 0.574938575 nan nan nan GO:0044249;GO:0044699;GO:0044267;GO:0044710;GO:0044711;GO:0044260;GO:0018193;GO:0071704;GO:0043687;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0018202;GO:0044238;GO:0019538;GO:0017182;GO:0009058;GO:0044237;GO:0043170;GO:0017183;GO:0044763; cellular biosynthetic process;single-organism process;cellular protein metabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular macromolecule metabolic process;peptidyl-amino acid modification;organic substance metabolic process;post-translational protein modification;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;peptidyl-histidine modification;primary metabolic process;protein metabolic process;peptidyl-diphthamide metabolic process;biosynthetic process;cellular metabolic process;macromolecule metabolic process;peptidyl-diphthamide biosynthetic process from peptidyl-histidine;single-organism cellular process; 4;2;5;3;4;4;7;3;7;2;6;5;5;1;2;8;3;4;9;3;3;4;4;3; GO:0005623;GO:0005622;GO:0005737;GO:0005829;GO:0044464;GO:0005575;GO:0044444;GO:0044424; cell;intracellular;cytoplasm;cytosol;cell part;cellular_component;cytoplasmic part;intracellular part; 2;3;4;5;2;1;4;3; GO:0003674;GO:0016765;GO:0016740;GO:0090560;GO:0003824; molecular_function;transferase activity, transferring alkyl or aryl (other than methyl) groups;transferase activity;2-(3-amino-3-carboxypropyl)histidine synthase activity;catalytic activity; 1;4;3;5;2; K17866 IPR010014;IPR016435; Diphthamide synthesis DHP2, eukaryotes;Diphthamide synthesis DPH1/DPH2; cytosol, nucleus Hs21536476 963.0 J [J] Translation, ribosomal structure and biogenesis; O60814 Histone H2B type 1-K OS=Homo sapiens OX=9606 GN=HIST1H2BK PE=1 SV=3 - [H2B1K_HUMAN] 0.798 0.644 1.111 1.609 0.613 1.512 1.239130435 0.443478071 2.624796085 0.02382979 1.72515528 0.122791137 2.466557912 0.003674626 GO:0019730;GO:0019731;GO:0071840;GO:0043207;GO:0009617;GO:0051707;GO:0051704;GO:0009607;GO:0002376;GO:0071103;GO:0022607;GO:0042742;GO:0016043;GO:0065003;GO:0002385;GO:0065004;GO:0006952;GO:0006950;GO:0008150;GO:0006955;GO:0006959;GO:0050896;GO:0034728;GO:0070271;GO:0031497;GO:0002227;GO:0009987;GO:0098542;GO:0006334;GO:0006333;GO:0043933;GO:0034622;GO:0071824;GO:0071822;GO:0006325;GO:0006323;GO:0009605;GO:0045087;GO:0006461;GO:0006996;GO:0051276;GO:0050830;GO:0044085;GO:0002251; antimicrobial humoral response;antibacterial humoral response;cellular component organization or biogenesis;response to external biotic stimulus;response to bacterium;response to other organism;multi-organism process;response to biotic stimulus;immune system process;DNA conformation change;cellular component assembly;defense response to bacterium;cellular component organization;macromolecular complex assembly;mucosal immune response;protein-DNA complex assembly;defense response;response to stress;biological_process;immune response;humoral immune response;response to stimulus;nucleosome organization;protein complex biogenesis;chromatin assembly;innate immune response in mucosa;cellular process;defense response to other organism;nucleosome assembly;chromatin assembly or disassembly;macromolecular complex subunit organization;cellular macromolecular complex assembly;protein-DNA complex subunit organization;protein complex subunit organization;chromatin organization;DNA packaging;response to external stimulus;innate immune response;protein complex assembly;organelle organization;chromosome organization;defense response to Gram-positive bacterium;cellular component biogenesis;organ or tissue specific immune response; 4;5;2;4;4;3;2;3;2;6;4;5;3;5;5;6;4;3;1;3;4;2;6;4;6;5;2;4;6;6;4;6;5;5;5;7;3;4;5;4;5;6;3;4; GO:0031974;GO:0005654;GO:0000790;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0000786;GO:0000788;GO:0000228;GO:0043227;GO:0043226;GO:0031981;GO:0044446;GO:0044815;GO:0005737;GO:0005634;GO:0044454;GO:0044464;GO:0005623;GO:0005622;GO:0000785;GO:0005615;GO:0005576;GO:0005694;GO:0032991;GO:0032993;GO:0005575;GO:0070013; membrane-enclosed lumen;nucleoplasm;nuclear chromatin;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;nucleosome;nuclear nucleosome;nuclear chromosome;membrane-bounded organelle;organelle;nuclear lumen;intracellular organelle part;DNA packaging complex;cytoplasm;nucleus;nuclear chromosome part;cell part;cell;intracellular;chromatin;extracellular space;extracellular region;chromosome;macromolecular complex;protein-DNA complex;cellular_component;intracellular organelle lumen; 2;5;4;3;4;4;3;4;3;4;2;2;3;3;4;5;5;3;2;5;3;4;4;5;5;2;2;3;3;3;2;5;2;3;1;4; GO:1901363;GO:0003674;GO:0003676;GO:0097159;GO:0005488;GO:0003677; heterocyclic compound binding;molecular_function;nucleic acid binding;organic cyclic compound binding;binding;DNA binding; 3;1;4;3;2;5; K11252 map05034;map05203;map05322; Alcoholism;Viral carcinogenesis;Systemic lupus erythematosus; IPR000558;IPR007125;IPR009072; Histone H2B;Histone H2A/H2B/H3;Histone-fold; nucleus Hs18105048 254.0 B [B] Chromatin structure and dynamics; Q9UQ16 Dynamin-3 OS=Homo sapiens OX=9606 GN=DNM3 PE=1 SV=4 - [DYN3_HUMAN] 1.007 1.24 0.66 0.81 1.574 0.782 0.812096774 0.703872016 0.514612452 0.038492456 0.532258065 0.664613457 0.49682338 0.179080705 GO:0048468;GO:0016358;GO:0060491;GO:0032989;GO:0031345;GO:0031344;GO:0071840;GO:0031346;GO:0097061;GO:0048869;GO:0051491;GO:0045665;GO:0045664;GO:0060998;GO:0010721;GO:0048518;GO:0048519;GO:0060996;GO:0060997;GO:0010977;GO:0010975;GO:0016192;GO:0044707;GO:0046847;GO:0022604;GO:0022607;GO:0022603;GO:0061002;GO:0061001;GO:0061000;GO:0031175;GO:0000904;GO:0000902;GO:0016043;GO:0065007;GO:0007416;GO:0051130;GO:0050793;GO:0006810;GO:0050794;GO:0008150;GO:0051239;GO:0051234;GO:0006897;GO:0048813;GO:0048812;GO:0048814;GO:0051961;GO:0044085;GO:0050808;GO:0030154;GO:0051129;GO:0051128;GO:0060284;GO:0051960;GO:0009653;GO:0044699;GO:0050767;GO:0051241;GO:0050768;GO:2000171;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0048858;GO:0051093;GO:0050774;GO:0007399;GO:0050773;GO:0010771;GO:0048731;GO:0030030;GO:0030031;GO:0007275;GO:0050789;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044763;GO:0010769;GO:0022008;GO:0051179;GO:0051489;GO:0048699;GO:0032990;GO:0048856;GO:0044087;GO:2000026;GO:0044089;GO:0048523;GO:0048522; cell development;dendrite development;regulation of cell projection assembly;cellular component morphogenesis;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;dendritic spine organization;cellular developmental process;positive regulation of filopodium assembly;negative regulation of neuron differentiation;regulation of neuron differentiation;regulation of dendritic spine development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;dendritic spine development;dendritic spine morphogenesis;negative regulation of neuron projection development;regulation of neuron projection development;vesicle-mediated transport;single-multicellular organism process;filopodium assembly;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;negative regulation of dendritic spine morphogenesis;regulation of dendritic spine morphogenesis;negative regulation of dendritic spine development;neuron projection development;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;biological regulation;synapse assembly;positive regulation of cellular component organization;regulation of developmental process;transport;regulation of cellular process;biological_process;regulation of multicellular organismal process;establishment of localization;endocytosis;dendrite morphogenesis;neuron projection morphogenesis;regulation of dendrite morphogenesis;negative regulation of nervous system development;cellular component biogenesis;synapse organization;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cell development;regulation of nervous system development;anatomical structure morphogenesis;single-organism process;regulation of neurogenesis;negative regulation of multicellular organismal process;negative regulation of neurogenesis;negative regulation of dendrite development;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;cell projection morphogenesis;negative regulation of developmental process;negative regulation of dendrite morphogenesis;nervous system development;regulation of dendrite development;negative regulation of cell morphogenesis involved in differentiation;system development;cell projection organization;cell projection assembly;multicellular organism development;regulation of biological process;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism cellular process;regulation of cell morphogenesis involved in differentiation;neurogenesis;localization;regulation of filopodium assembly;generation of neurons;cell part morphogenesis;anatomical structure development;regulation of cellular component biogenesis;regulation of multicellular organismal development;positive regulation of cellular component biogenesis;negative regulation of cellular process;positive regulation of cellular process; 4;4;4;4;5;5;2;5;5;4;4;6;7;5;5;2;2;4;5;6;6;5;3;6;5;4;4;6;6;5;5;5;5;3;2;5;4;3;4;3;1;3;3;6;5;6;6;4;3;4;5;4;4;5;5;3;2;6;3;5;5;2;2;2;4;4;5;3;6;5;5;5;4;4;5;4;2;5;6;6;3;3;6;6;2;5;7;5;3;3;4;3;3;3; GO:0099512;GO:0099513;GO:0030425;GO:0030424;GO:0044327;GO:0031982;GO:0005794;GO:0036477;GO:0042995;GO:0043231;GO:0043230;GO:0001917;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0048471;GO:0012505;GO:0060076;GO:0044446;GO:0043083;GO:0005874;GO:0005737;GO:0044456;GO:0043005;GO:0014069;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0099572;GO:0005739;GO:0045202;GO:0043232;GO:0070062;GO:0044309;GO:0044444;GO:0097458;GO:0005576;GO:0015630;GO:1903561;GO:0043197;GO:0005575;GO:0098794; supramolecular fiber;polymeric cytoskeletal fiber;dendrite;axon;dendritic spine head;vesicle;Golgi apparatus;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;extracellular organelle;photoreceptor inner segment;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;perinuclear region of cytoplasm;endomembrane system;excitatory synapse;intracellular organelle part;synaptic cleft;microtubule;cytoplasm;synapse part;neuron projection;postsynaptic density;cell projection part;cell part;cell;intracellular;postsynaptic specialization;mitochondrion;synapse;intracellular non-membrane-bounded organelle;extracellular exosome;neuron spine;cytoplasmic part;neuron part;extracellular region;microtubule cytoskeleton;extracellular vesicle;dendritic spine;cellular_component;postsynapse; 2;3;5;5;3;4;4;4;3;4;3;4;3;2;2;3;3;3;2;5;4;5;3;3;3;3;4;4;2;4;4;3;2;2;3;3;5;2;4;4;5;4;3;2;6;3;4;1;3; GO:0000166;GO:0003924;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005525;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0032561;GO:0001883;GO:0001882;GO:0019001;GO:0017111;GO:0043168; nucleotide binding;GTPase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;GTP binding;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;guanyl ribonucleotide binding;purine nucleoside binding;nucleoside binding;guanyl nucleotide binding;nucleoside-triphosphatase activity;anion binding; 4;8;5;3;4;1;2;4;3;5;5;6;3;2;3;3;6;5;6;4;5;3;6;5;4;6;7;4; K01528 map04072;map04144;map04721;map04961;map05100; Phospholipase D signaling pathway;Endocytosis;Synaptic vesicle cycle;Endocrine and other factor-regulated calcium reabsorption;Bacterial invasion of epithelial cells; IPR020850;IPR022812;IPR003130;IPR001401;IPR027743;IPR019762;IPR030381;IPR001849;IPR011993;IPR000375;IPR027417; GTPase effector domain;Dynamin superfamily;Dynamin GTPase effector;Dynamin, GTPase domain;Dynamin-3;Dynamin, GTPase region, conserved site;Dynamin-type guanine nucleotide-binding (G) domain;Pleckstrin homology domain;PH domain-like;Dynamin central domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs22042377 1755.0 UR [U] Intracellular trafficking, secretion, and vesicular transport;[R] General function prediction only; Q13467 Frizzled-5 OS=Homo sapiens OX=9606 GN=FZD5 PE=1 SV=2 - [FZD5_HUMAN] 1.013 1.095 0.82 1.103 1.253 0.888 0.925114155 nan 0.88028731 nan 0.748858447 nan 0.708699122 nan GO:0033157;GO:0045216;GO:0051049;GO:0002706;GO:0002705;GO:0002703;GO:0002702;GO:0002700;GO:0032388;GO:1903867;GO:0002709;GO:0002708;GO:0051716;GO:0000003;GO:0043207;GO:0000165;GO:0048584;GO:0048468;GO:0002824;GO:0045859;GO:0002822;GO:0002821;GO:0046330;GO:0051222;GO:0006839;GO:0046483;GO:0042325;GO:0042327;GO:0009607;GO:0009605;GO:0019538;GO:0002369;GO:0010638;GO:0030111;GO:0009894;GO:0048562;GO:0009893;GO:0009891;GO:0090263;GO:0048568;GO:0031077;GO:0031076;GO:0051254;GO:0030177;GO:0060061;GO:0000578;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0051347;GO:0009948;GO:0006886;GO:0002684;GO:0002682;GO:0018130;GO:0070201;GO:0098602;GO:0033077;GO:0098609;GO:0043410;GO:0043412;GO:0007351;GO:0007350;GO:0002521;GO:0002520;GO:0016070;GO:0010557;GO:0010556;GO:0009967;GO:0051128;GO:1903827;GO:0008285;GO:0001654;GO:0034329;GO:0060715;GO:0060341;GO:0010821;GO:0010822;GO:0008219;GO:0007275;GO:0003002;GO:2000112;GO:0048598;GO:0006468;GO:0019219;GO:0048592;GO:0048593;GO:0090316;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0045184;GO:0002699;GO:0048856;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0008104;GO:0007165;GO:0007166;GO:0002456;GO:0007005;GO:0044712;GO:0044710;GO:0044093;GO:0033036;GO:0030217;GO:1903955;GO:2001141;GO:0051707;GO:0010033;GO:0051704;GO:0023056;GO:0044249;GO:0031667;GO:0045321;GO:0001763;GO:0010623;GO:0046328;GO:0044267;GO:0010646;GO:0044260;GO:0001568;GO:0007416;GO:0006366;GO:0032880;GO:0009887;GO:0034613;GO:0009880;GO:0050790;GO:0009889;GO:0009888;GO:0050794;GO:0060070;GO:0048596;GO:0051239;GO:0051234;GO:0009953;GO:0009952;GO:0009950;GO:0050896;GO:0051338;GO:0002697;GO:1903146;GO:0043010;GO:0010562;GO:0032107;GO:0032104;GO:0033043;GO:0001944;GO:0051173;GO:0051247;GO:0043406;GO:0043405;GO:0007043;GO:1903533;GO:0044699;GO:0043408;GO:0051240;GO:0051246;GO:0031098;GO:0048569;GO:0031399;GO:0048608;GO:0070302;GO:0070304;GO:1903008;GO:1903747;GO:1903749;GO:0002460;GO:0070830;GO:1902680;GO:0002237;GO:0033365;GO:0048731;GO:0016337;GO:0061458;GO:0034330;GO:0016236;GO:0002724;GO:0001525;GO:0002720;GO:0048048;GO:0051223;GO:1901360;GO:1902589;GO:0072594;GO:0016241;GO:0045935;GO:0031128;GO:0030182;GO:0061138;GO:0022414;GO:0070489;GO:0042221;GO:0022008;GO:0070486;GO:0006996;GO:0044238;GO:0044237;GO:1903214;GO:0043297;GO:0060718;GO:0019220;GO:0019222;GO:0060711;GO:0032386;GO:0060713;GO:0048583;GO:0048469;GO:0060716;GO:0060717;GO:0072359;GO:0072358;GO:1901362;GO:0071840;GO:0009966;GO:0048869;GO:0048513;GO:0048514;GO:0032729;GO:0048518;GO:0048519;GO:0042127;GO:1901888;GO:0006605;GO:0003006;GO:0060669;GO:0072655;GO:0035282;GO:0044700;GO:0044702;GO:0044707;GO:0016055;GO:0002376;GO:0033554;GO:0060828;GO:0022607;GO:0033674;GO:2000810;GO:0043170;GO:0021700;GO:0097659;GO:1903649;GO:0043549;GO:0071219;GO:0071216;GO:0006626;GO:0048646;GO:0006810;GO:0012501;GO:0006950;GO:0006955;GO:0034654;GO:1902533;GO:1902531;GO:0044271;GO:0007423;GO:0080134;GO:0080135;GO:0001775;GO:0006355;GO:0006357;GO:0006351;GO:0032774;GO:0030154;GO:1904951;GO:0006139;GO:0007254;GO:0001701;GO:0032270;GO:0043009;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0032872;GO:0032874;GO:0032879;GO:0016482;GO:0090304;GO:0050776;GO:0046907;GO:0000422;GO:0051252;GO:0050778;GO:0001816;GO:0001817;GO:0001819;GO:0032609;GO:0031401;GO:0042110;GO:0043506;GO:0043507;GO:0010628;GO:0007389;GO:0002726;GO:0051050;GO:0032101;GO:0071704;GO:0048729;GO:0071702;GO:0010506;GO:1901382;GO:0090596;GO:0061726;GO:0006914;GO:0006915;GO:0051174;GO:0002711;GO:0009058;GO:0009059;GO:0051171;GO:0051649;GO:0002718;GO:0044332;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:1902582;GO:1902580;GO:0080090;GO:0023014;GO:0010604;GO:0070727;GO:0009617;GO:0060255;GO:0060706;GO:0046649;GO:0035567;GO:0070585;GO:0097360;GO:1903651;GO:0032649;GO:0060670;GO:0002440;GO:0060674;GO:1901576;GO:0045937;GO:0016043;GO:0002367;GO:0065007;GO:1903829;GO:0065009;GO:0071593;GO:0071594;GO:0051130;GO:0036211;GO:0008150;GO:0008152;GO:0019438;GO:0008595;GO:0022411;GO:0050808;GO:0016310;GO:0002819;GO:0009791;GO:0009790;GO:0034641;GO:0009792;GO:0023052;GO:0034645;GO:0023051;GO:0009798;GO:0010647;GO:0009653;GO:0043085;GO:0022610;GO:0060429;GO:0045893;GO:0001892;GO:0060561;GO:0001890;GO:0032268;GO:0006807;GO:0045944;GO:0030098;GO:0030097;GO:0045860;GO:1903508;GO:0009991;GO:0031329;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0002009;GO:0008283;GO:0010467;GO:0048534;GO:0010468;GO:0002449;GO:0051403;GO:0007159;GO:0007155;GO:0007154;GO:0002443;GO:0044248;GO:0048699;GO:0007399;GO:0044087;GO:0044085;GO:0002250;GO:0002252;GO:0015031;GO:0001932;GO:0001934;GO:1902742; regulation of intracellular protein transport;cell-cell junction organization;regulation of transport;regulation of lymphocyte mediated immunity;positive regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;positive regulation of production of molecular mediator of immune response;regulation of production of molecular mediator of immune response;positive regulation of intracellular transport;extraembryonic membrane development;regulation of T cell mediated immunity;positive regulation of lymphocyte mediated immunity;cellular response to stimulus;reproduction;response to external biotic stimulus;MAPK cascade;positive regulation of response to stimulus;cell development;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of protein kinase activity;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of adaptive immune response;positive regulation of JNK cascade;positive regulation of protein transport;mitochondrial transport;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to biotic stimulus;response to external stimulus;protein metabolic process;T cell cytokine production;positive regulation of organelle organization;regulation of Wnt signaling pathway;regulation of catabolic process;embryonic organ morphogenesis;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of canonical Wnt signaling pathway;embryonic organ development;post-embryonic camera-type eye development;embryonic camera-type eye development;positive regulation of RNA metabolic process;positive regulation of Wnt signaling pathway;Spemann organizer formation;embryonic axis specification;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;positive regulation of transferase activity;anterior/posterior axis specification;intracellular protein transport;positive regulation of immune system process;regulation of immune system process;heterocycle biosynthetic process;regulation of establishment of protein localization;single organism cell adhesion;T cell differentiation in thymus;cell-cell adhesion;positive regulation of MAPK cascade;macromolecule modification;tripartite regional subdivision;blastoderm segmentation;leukocyte differentiation;immune system development;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;positive regulation of signal transduction;regulation of cellular component organization;regulation of cellular protein localization;negative regulation of cell proliferation;eye development;cell junction assembly;syncytiotrophoblast cell differentiation involved in labyrinthine layer development;regulation of cellular localization;regulation of mitochondrion organization;positive regulation of mitochondrion organization;cell death;multicellular organism development;regionalization;regulation of cellular macromolecule biosynthetic process;embryonic morphogenesis;protein phosphorylation;regulation of nucleobase-containing compound metabolic process;eye morphogenesis;camera-type eye morphogenesis;positive regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of protein localization;positive regulation of immune effector process;anatomical structure development;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;protein localization;signal transduction;cell surface receptor signaling pathway;T cell mediated immunity;mitochondrion organization;single-organism catabolic process;single-organism metabolic process;positive regulation of molecular function;macromolecule localization;T cell differentiation;positive regulation of protein targeting to mitochondrion;regulation of RNA biosynthetic process;response to other organism;response to organic substance;multi-organism process;positive regulation of signaling;cellular biosynthetic process;response to nutrient levels;leukocyte activation;morphogenesis of a branching structure;developmental programmed cell death;regulation of JNK cascade;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;blood vessel development;synapse assembly;transcription from RNA polymerase II promoter;regulation of protein localization;organ morphogenesis;cellular protein localization;embryonic pattern specification;regulation of catalytic activity;regulation of biosynthetic process;tissue development;regulation of cellular process;canonical Wnt signaling pathway;embryonic camera-type eye morphogenesis;regulation of multicellular organismal process;establishment of localization;dorsal/ventral pattern formation;anterior/posterior pattern specification;dorsal/ventral axis specification;response to stimulus;regulation of transferase activity;regulation of immune effector process;regulation of mitophagy;camera-type eye development;positive regulation of phosphorus metabolic process;regulation of response to nutrient levels;regulation of response to extracellular stimulus;regulation of organelle organization;vasculature development;positive regulation of nitrogen compound metabolic process;positive regulation of protein metabolic process;positive regulation of MAP kinase activity;regulation of MAP kinase activity;cell-cell junction assembly;regulation of protein targeting;single-organism process;regulation of MAPK cascade;positive regulation of multicellular organismal process;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;post-embryonic organ development;regulation of protein modification process;reproductive structure development;regulation of stress-activated protein kinase signaling cascade;positive regulation of stress-activated protein kinase signaling cascade;organelle disassembly;regulation of establishment of protein localization to mitochondrion;positive regulation of establishment of protein localization to mitochondrion;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;bicellular tight junction assembly;positive regulation of RNA biosynthetic process;response to molecule of bacterial origin;protein localization to organelle;system development;single organismal cell-cell adhesion;reproductive system development;cell junction organization;macroautophagy;regulation of T cell cytokine production;angiogenesis;positive regulation of cytokine production involved in immune response;embryonic eye morphogenesis;regulation of protein transport;organic cyclic compound metabolic process;single-organism organelle organization;establishment of protein localization to organelle;regulation of macroautophagy;positive regulation of nucleobase-containing compound metabolic process;developmental induction;neuron differentiation;morphogenesis of a branching epithelium;reproductive process;T cell aggregation;response to chemical;neurogenesis;leukocyte aggregation;organelle organization;primary metabolic process;cellular metabolic process;regulation of protein targeting to mitochondrion;apical junction assembly;chorionic trophoblast cell differentiation;regulation of phosphate metabolic process;regulation of metabolic process;labyrinthine layer development;regulation of intracellular transport;labyrinthine layer morphogenesis;regulation of response to stimulus;cell maturation;labyrinthine layer blood vessel development;chorion development;circulatory system development;cardiovascular system development;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;regulation of signal transduction;cellular developmental process;animal organ development;blood vessel morphogenesis;positive regulation of interferon-gamma production;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;regulation of cell junction assembly;protein targeting;developmental process involved in reproduction;embryonic placenta morphogenesis;establishment of protein localization to mitochondrion;segmentation;single organism signaling;single organism reproductive process;single-multicellular organism process;Wnt signaling pathway;immune system process;cellular response to stress;regulation of canonical Wnt signaling pathway;cellular component assembly;positive regulation of kinase activity;regulation of bicellular tight junction assembly;macromolecule metabolic process;developmental maturation;nucleic acid-templated transcription;regulation of cytoplasmic transport;regulation of kinase activity;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;protein targeting to mitochondrion;anatomical structure formation involved in morphogenesis;transport;programmed cell death;response to stress;immune response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;cellular nitrogen compound biosynthetic process;sensory organ development;regulation of response to stress;regulation of cellular response to stress;cell activation;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cell differentiation;positive regulation of establishment of protein localization;nucleobase-containing compound metabolic process;JNK cascade;in utero embryonic development;positive regulation of cellular protein metabolic process;chordate embryonic development;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of stress-activated MAPK cascade;positive regulation of stress-activated MAPK cascade;regulation of localization;cytosolic transport;nucleic acid metabolic process;regulation of immune response;intracellular transport;mitophagy;regulation of RNA metabolic process;positive regulation of immune response;cytokine production;regulation of cytokine production;positive regulation of cytokine production;interferon-gamma production;positive regulation of protein modification process;T cell activation;regulation of JUN kinase activity;positive regulation of JUN kinase activity;positive regulation of gene expression;pattern specification process;positive regulation of T cell cytokine production;positive regulation of transport;regulation of response to external stimulus;organic substance metabolic process;tissue morphogenesis;organic substance transport;regulation of autophagy;regulation of chorionic trophoblast cell proliferation;sensory organ morphogenesis;mitochondrion disassembly;autophagy;apoptotic process;regulation of phosphorus metabolic process;positive regulation of T cell mediated immunity;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;establishment of localization in cell;regulation of cytokine production involved in immune response;Wnt signaling pathway involved in dorsal/ventral axis specification;catabolic process;localization;single-organism localization;cellular localization;single-organism intracellular transport;single-organism cellular localization;regulation of primary metabolic process;signal transduction by protein phosphorylation;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to bacterium;regulation of macromolecule metabolic process;cell differentiation involved in embryonic placenta development;lymphocyte activation;non-canonical Wnt signaling pathway;protein localization to mitochondrion;chorionic trophoblast cell proliferation;positive regulation of cytoplasmic transport;regulation of interferon-gamma production;branching involved in labyrinthine layer morphogenesis;production of molecular mediator of immune response;placenta blood vessel development;organic substance biosynthetic process;positive regulation of phosphate metabolic process;cellular component organization;cytokine production involved in immune response;biological regulation;positive regulation of cellular protein localization;regulation of molecular function;lymphocyte aggregation;thymocyte aggregation;positive regulation of cellular component organization;protein modification process;biological_process;metabolic process;aromatic compound biosynthetic process;anterior/posterior axis specification, embryo;cellular component disassembly;synapse organization;phosphorylation;regulation of adaptive immune response;post-embryonic development;embryo development;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;cellular macromolecule biosynthetic process;regulation of signaling;axis specification;positive regulation of cell communication;anatomical structure morphogenesis;positive regulation of catalytic activity;biological adhesion;epithelium development;positive regulation of transcription, DNA-templated;embryonic placenta development;apoptotic process involved in morphogenesis;placenta development;regulation of cellular protein metabolic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;lymphocyte differentiation;hemopoiesis;positive regulation of protein kinase activity;positive regulation of nucleic acid-templated transcription;response to extracellular stimulus;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;morphogenesis of an epithelium;cell proliferation;gene expression;hematopoietic or lymphoid organ development;regulation of gene expression;lymphocyte mediated immunity;stress-activated MAPK cascade;leukocyte cell-cell adhesion;cell adhesion;cell communication;leukocyte mediated immunity;cellular catabolic process;generation of neurons;nervous system development;regulation of cellular component biogenesis;cellular component biogenesis;adaptive immune response;immune effector process;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;apoptotic process involved in development; 6;5;4;6;5;5;4;4;4;4;7;6;3;2;4;5;3;4;6;7;6;5;8;4;6;4;7;7;3;3;4;5;5;5;4;5;3;4;6;4;5;5;5;5;4;6;9;5;8;2;6;6;6;3;3;5;5;3;6;4;6;5;6;6;6;3;5;5;5;4;4;5;4;5;5;5;4;6;6;4;4;5;6;4;7;5;6;7;4;6;3;4;3;4;4;3;5;4;3;3;4;4;5;6;5;4;3;4;3;6;5;6;3;4;2;3;4;5;3;4;5;7;5;4;4;4;5;7;4;4;5;5;4;4;4;3;7;6;3;3;6;6;6;2;5;4;5;6;5;6;5;5;5;4;5;7;7;6;7;2;6;3;5;5;4;6;4;5;6;5;6;4;5;7;6;5;6;4;4;5;4;4;6;4;5;6;5;4;4;5;5;5;3;6;5;2;4;3;6;6;4;3;3;6;7;5;6;3;4;5;4;3;5;5;4;5;5;5;2;4;4;4;4;5;2;2;4;4;6;3;4;6;6;3;3;3;6;2;4;6;4;7;5;4;4;7;6;6;5;4;5;3;4;5;3;3;5;5;5;5;4;4;4;4;6;7;6;6;5;3;4;7;8;5;7;2;2;2;4;7;6;7;3;6;5;4;5;4;5;4;4;4;4;5;6;5;8;8;5;4;6;3;4;3;4;5;4;5;5;6;3;6;5;7;3;5;4;4;5;7;3;2;3;3;5;4;4;4;4;4;4;4;4;4;7;7;4;5;5;4;3;4;4;6;3;4;2;3;3;7;5;4;5;1;2;5;7;4;4;6;5;4;5;4;6;2;5;3;5;4;3;5;2;5;6;4;4;4;5;3;7;5;5;8;7;4;5;5;5;4;4;5;3;5;4;5;5;6;5;3;4;4;4;7;5;3;3;4;3;5;7;7;4; GO:0048471;GO:0044424;GO:0044425;GO:0044422;GO:0030054;GO:0070160;GO:0005773;GO:0031224;GO:0010008;GO:0030669;GO:0005911;GO:0071944;GO:0005768;GO:0005769;GO:0016023;GO:0016021;GO:0016020;GO:0098588;GO:0043231;GO:0005923;GO:0044433;GO:0044431;GO:0044437;GO:0030665;GO:0030666;GO:0031090;GO:0030662;GO:0043227;GO:0043296;GO:0005774;GO:0031901;GO:0043229;GO:0043226;GO:0045334;GO:0012505;GO:0012506;GO:0031982;GO:0044446;GO:0044444;GO:0044440;GO:0005737;GO:0009986;GO:0030659;GO:0031988;GO:0005794;GO:0044464;GO:0097708;GO:0000139;GO:0031410;GO:0005623;GO:0005622;GO:0030139;GO:0030135;GO:0030136;GO:0098805;GO:0005886;GO:0005575; perinuclear region of cytoplasm;intracellular part;membrane part;organelle part;cell junction;occluding junction;vacuole;intrinsic component of membrane;endosome membrane;clathrin-coated endocytic vesicle membrane;cell-cell junction;cell periphery;endosome;early endosome;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;bounding membrane of organelle;intracellular membrane-bounded organelle;bicellular tight junction;cytoplasmic vesicle part;Golgi apparatus part;vacuolar part;clathrin-coated vesicle membrane;endocytic vesicle membrane;organelle membrane;coated vesicle membrane;membrane-bounded organelle;apical junction complex;vacuolar membrane;early endosome membrane;intracellular organelle;organelle;clathrin-coated endocytic vesicle;endomembrane system;vesicle membrane;vesicle;intracellular organelle part;cytoplasmic part;endosomal part;cytoplasm;cell surface;cytoplasmic vesicle membrane;membrane-bounded vesicle;Golgi apparatus;cell part;intracellular vesicle;Golgi membrane;cytoplasmic vesicle;cell;intracellular;endocytic vesicle;coated vesicle;clathrin-coated vesicle;whole membrane;plasma membrane;cellular_component; 5;3;2;2;2;4;5;3;5;5;3;3;4;5;5;4;2;4;4;5;4;4;4;5;4;3;4;3;4;4;6;3;2;7;3;4;4;3;4;5;4;3;5;5;4;2;4;5;5;2;3;6;6;7;3;3;1; GO:0005488;GO:0019900;GO:0099600;GO:0019899;GO:0033218;GO:0031625;GO:0005515;GO:0060089;GO:0019901;GO:0003674;GO:0042277;GO:0044389;GO:0004888;GO:0004930;GO:0001540;GO:0042813;GO:0017147;GO:0038023;GO:0004872;GO:0004871; binding;kinase binding;transmembrane receptor activity;enzyme binding;amide binding;ubiquitin protein ligase binding;protein binding;molecular transducer activity;protein kinase binding;molecular_function;peptide binding;ubiquitin-like protein ligase binding;transmembrane signaling receptor activity;G-protein coupled receptor activity;beta-amyloid binding;Wnt-activated receptor activity;Wnt-protein binding;signaling receptor activity;receptor activity;signal transducer activity; 2;5;4;4;3;6;3;2;6;1;4;5;4;5;5;5;4;3;3;2; K02375 map04310;map04390;map04550;map04916;map05166;map05200;map05205;map05217; Wnt signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Melanogenesis;HTLV-I infection;Pathways in cancer;Proteoglycans in cancer;Basal cell carcinoma; IPR026547;IPR020067;IPR017981;IPR000539;IPR015526; Frizzled-5;Frizzled domain;GPCR, family 2-like;Frizzled/Smoothened, transmembrane domain;Frizzled/secreted frizzled-related protein; plasma membrane Hs17437841 1203.0 T [T] Signal transduction mechanisms; P20742 Pregnancy zone protein OS=Homo sapiens OX=9606 GN=PZP PE=1 SV=4 - [PZP_HUMAN] 1.06 1.042 0.895 1.196 1.041 0.834 1.017274472 0.962816513 1.148895293 0.00422009 0.858925144 0.015822104 0.801152738 0.965292193 GO:0009892;GO:0019222;GO:0031324;GO:0031323;GO:0045861;GO:0008152;GO:0050789;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0051704;GO:0032501;GO:0052547;GO:0052548;GO:0050794;GO:0022414;GO:0008150;GO:0010951;GO:0051346;GO:0006508;GO:0000003;GO:0051336;GO:0044238;GO:0044703;GO:0032268;GO:0050790;GO:0044706;GO:0060255;GO:0007565;GO:0044237;GO:0043170;GO:0019538;GO:0032269;GO:0030162;GO:0009987;GO:0048523; negative regulation of metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of proteolysis;metabolic process;regulation of biological process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;multi-organism process;multicellular organismal process;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular process;reproductive process;biological_process;negative regulation of endopeptidase activity;negative regulation of hydrolase activity;proteolysis;reproduction;regulation of hydrolase activity;primary metabolic process;multi-organism reproductive process;regulation of cellular protein metabolic process;regulation of catalytic activity;multi-multicellular organism process;regulation of macromolecule metabolic process;female pregnancy;cellular metabolic process;macromolecule metabolic process;protein metabolic process;negative regulation of cellular protein metabolic process;regulation of proteolysis;cellular process;negative regulation of cellular process; 3;3;4;4;6;2;2;4;5;5;4;4;5;5;3;7;2;4;2;3;2;2;6;7;3;2;1;8;6;5;2;5;3;3;5;4;3;4;4;3;4;4;5;6;2;3; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0072562;GO:0031982;GO:1903561;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;blood microparticle;vesicle;extracellular vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;4;3;3;1;2;2; GO:0030414;GO:0003674;GO:0004857;GO:0098772;GO:0061135;GO:0030234;GO:0061134;GO:0004866;GO:0004867; peptidase inhibitor activity;molecular_function;enzyme inhibitor activity;molecular function regulator;endopeptidase regulator activity;enzyme regulator activity;peptidase regulator activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity; 5;1;4;2;5;3;4;6;7; K23589 IPR011626;IPR013783;IPR009048;IPR010916;IPR019742;IPR001599;IPR014756;IPR008930;IPR002890;IPR019565;IPR011625; Alpha-macroglobulin complement component;Immunoglobulin-like fold;Alpha-macroglobulin, receptor-binding;TonB box, conserved site;Alpha-2-macroglobulin, conserved site;Alpha-2-macroglobulin;Immunoglobulin E-set;Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;Alpha-2-macroglobulin, N-terminal;Alpha-2-macroglobulin, thiol-ester bond-forming;Alpha-2-macroglobulin, N-terminal 2; extracellular Hs4506355 3070.0 O [O] Posttranslational modification, protein turnover, chaperones; Q16787 Laminin subunit alpha-3 OS=Homo sapiens OX=9606 GN=LAMA3 PE=1 SV=2 - [LAMA3_HUMAN] 0.934 1.182 0.775 1.007 1.317 1.132 0.790186125 nan 0.764616553 nan 0.655668359 nan 0.859529233 nan GO:0048598;GO:0007492;GO:0022607;GO:0045995;GO:0060429;GO:0030155;GO:0034330;GO:0030154;GO:0009790;GO:0007044;GO:0008544;GO:0007155;GO:0051179;GO:0071840;GO:0032879;GO:0001706;GO:0051674;GO:0009653;GO:0048869;GO:0007369;GO:0006928;GO:0016043;GO:0050789;GO:0040012;GO:0030198;GO:0065007;GO:0044699;GO:0043062;GO:2000026;GO:0016477;GO:0022617;GO:0032501;GO:0032502;GO:0040011;GO:0030334;GO:0050793;GO:0031581;GO:0009987;GO:0009888;GO:0050794;GO:0044767;GO:0051270;GO:0008150;GO:0051239;GO:0035987;GO:0034329;GO:0001704;GO:0044707;GO:0048870;GO:0022610;GO:0048856;GO:0044763;GO:2000145;GO:0048646;GO:0007275;GO:0022411;GO:0044085; embryonic morphogenesis;endoderm development;cellular component assembly;regulation of embryonic development;epithelium development;regulation of cell adhesion;cell junction organization;cell differentiation;embryo development;cell-substrate junction assembly;epidermis development;cell adhesion;localization;cellular component organization or biogenesis;regulation of localization;endoderm formation;localization of cell;anatomical structure morphogenesis;cellular developmental process;gastrulation;movement of cell or subcellular component;cellular component organization;regulation of biological process;regulation of locomotion;extracellular matrix organization;biological regulation;single-organism process;extracellular structure organization;regulation of multicellular organismal development;cell migration;extracellular matrix disassembly;multicellular organismal process;developmental process;locomotion;regulation of cell migration;regulation of developmental process;hemidesmosome assembly;cellular process;tissue development;regulation of cellular process;single-organism developmental process;regulation of cellular component movement;biological_process;regulation of multicellular organismal process;endodermal cell differentiation;cell junction assembly;formation of primary germ layer;single-multicellular organism process;cell motility;biological adhesion;anatomical structure development;single-organism cellular process;regulation of cell motility;anatomical structure formation involved in morphogenesis;multicellular organism development;cellular component disassembly;cellular component biogenesis; 4;5;4;5;5;4;4;5;5;6;6;3;2;2;3;5;3;3;4;5;4;3;2;3;5;2;2;4;4;4;5;2;2;2;5;3;7;2;4;3;3;4;1;3;6;5;4;3;3;2;3;3;4;3;4;4;3; GO:0031012;GO:0043227;GO:0043226;GO:0005610;GO:0070062;GO:0043256;GO:0043230;GO:1903561;GO:0031982;GO:0043234;GO:0005605;GO:0005604;GO:0032991;GO:0044421;GO:0005575;GO:0005576;GO:0044420;GO:0005578; extracellular matrix;membrane-bounded organelle;organelle;laminin-5 complex;extracellular exosome;laminin complex;extracellular organelle;extracellular vesicle;vesicle;protein complex;basal lamina;basement membrane;macromolecular complex;extracellular region part;cellular_component;extracellular region;extracellular matrix component;proteinaceous extracellular matrix; 2;3;2;4;4;3;3;3;4;3;3;3;2;2;1;2;2;3; GO:0003674;GO:0005198; molecular_function;structural molecule activity; 1;2; K06240 map01100;map04151;map04510;map04512;map05145;map05146;map05200;map05222; Metabolic pathways;PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer; IPR000742;IPR008979;IPR013320;IPR009254;IPR010307;IPR000034;IPR008211;IPR013032;IPR001791;IPR002049; EGF-like domain;Galactose-binding domain-like;Concanavalin A-like lectin/glucanase domain;Laminin alpha, domain I;Laminin domain II;Laminin IV;Laminin, N-terminal;EGF-like, conserved site;Laminin G domain;Laminin EGF domain; extracellular Hs4557711 3429.0 W [W] Extracellular structures; Q15075 Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2 - [EEA1_HUMAN] 1.015 1.023 1.055 1.265 1.161 nan 0.992179863 nan 1.08957795 nan 1.031280547 nan nan nan GO:0006906;GO:0061025;GO:0061024;GO:0071840;GO:0016189;GO:0097576;GO:0045022;GO:0016197;GO:0016192;GO:0090174;GO:0051469;GO:0016050;GO:0016043;GO:0098927;GO:0006810;GO:0008150;GO:0044801;GO:0051234;GO:0006897;GO:0046907;GO:0044802;GO:0099532;GO:0044699;GO:0009987;GO:0016482;GO:0007033;GO:0007034;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:1902589;GO:0048284;GO:1902582; vesicle fusion;membrane fusion;membrane organization;cellular component organization or biogenesis;synaptic vesicle to endosome fusion;vacuole fusion;early endosome to late endosome transport;endosomal transport;vesicle-mediated transport;organelle membrane fusion;vesicle fusion with vacuole;vesicle organization;cellular component organization;vesicle-mediated transport between endosomal compartments;transport;biological_process;single-organism membrane fusion;establishment of localization;endocytosis;intracellular transport;single-organism membrane organization;synaptic vesicle processing via endosome;single-organism process;cellular process;cytosolic transport;vacuole organization;vacuolar transport;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;single-organism organelle organization;organelle fusion;single-organism intracellular transport; 6;5;4;2;8;6;7;7;5;5;7;5;3;6;4;1;5;3;6;5;4;8;2;2;6;5;6;4;3;4;2;3;3;4;4;5;5; GO:0030424;GO:0031982;GO:0005773;GO:0016020;GO:0005774;GO:0031901;GO:0043234;GO:1902494;GO:0098588;GO:1990234;GO:0042995;GO:0043231;GO:0043230;GO:0005829;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044437;GO:0012505;GO:0044446;GO:0044444;GO:0044440;GO:0033267;GO:0097708;GO:0019897;GO:0055037;GO:0005886;GO:0019898;GO:0010008;GO:0005737;GO:0031090;GO:0031410;GO:0043005;GO:0044459;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0098805;GO:0005969;GO:0044309;GO:0044308;GO:0097458;GO:1903561;GO:0032991;GO:0005575;GO:0005576;GO:0005768;GO:0005769; axon;vesicle;vacuole;membrane;vacuolar membrane;early endosome membrane;protein complex;catalytic complex;bounding membrane of organelle;transferase complex;cell projection;intracellular membrane-bounded organelle;extracellular organelle;cytosol;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;vacuolar part;endomembrane system;intracellular organelle part;cytoplasmic part;endosomal part;axon part;intracellular vesicle;extrinsic component of plasma membrane;recycling endosome;plasma membrane;extrinsic component of membrane;endosome membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;neuron projection;plasma membrane part;cell projection part;cell part;cell;intracellular;cell periphery;extracellular exosome;whole membrane;serine-pyruvate aminotransferase complex;neuron spine;axonal spine;neuron part;extracellular vesicle;macromolecular complex;cellular_component;extracellular region;endosome;early endosome; 5;4;5;2;4;6;3;4;4;5;3;4;3;5;3;2;2;2;3;3;2;4;3;3;4;5;4;4;4;5;3;3;5;4;3;5;4;3;3;2;2;3;3;4;3;5;5;5;3;3;2;1;2;4;5; GO:0046983;GO:0008270;GO:0030742;GO:0005545;GO:0046872;GO:0003674;GO:0005488;GO:0046914;GO:0043168;GO:0035091;GO:0005543;GO:0043169;GO:0043167;GO:0042802;GO:0042803;GO:0008289;GO:0005516;GO:0005515; protein dimerization activity;zinc ion binding;GTP-dependent protein binding;1-phosphatidylinositol binding;metal ion binding;molecular_function;binding;transition metal ion binding;anion binding;phosphatidylinositol binding;phospholipid binding;cation binding;ion binding;identical protein binding;protein homodimerization activity;lipid binding;calmodulin binding;protein binding; 4;7;4;6;5;1;2;6;4;5;4;4;3;4;5;3;4;3; K12478 map04144;map04145;map05152; Endocytosis;Phagosome;Tuberculosis; IPR013087;IPR011011;IPR017455;IPR013083;IPR000306; Zinc finger C2H2-type;Zinc finger, FYVE/PHD-type;Zinc finger, FYVE-related;Zinc finger, RING/FYVE/PHD-type;FYVE zinc finger; nucleus O95445 Apolipoprotein M OS=Homo sapiens OX=9606 GN=APOM PE=1 SV=2 - [APOM_HUMAN] 1.022 1.173 0.817 0.955 1.204 1.208 0.871270247 0.001011915 0.793189369 6.59E-05 0.696504689 0.055873354 1.003322259 0.633666269 GO:0034441;GO:0034443;GO:0006775;GO:0034445;GO:0080090;GO:0019222;GO:0033344;GO:0034442;GO:0044281;GO:0071840;GO:0034444;GO:0044710;GO:0010605;GO:0098869;GO:0016101;GO:0065007;GO:0033036;GO:0006766;GO:0034367;GO:0034368;GO:0034369;GO:0007603;GO:0007602;GO:1990748;GO:0023052;GO:0043691;GO:0010876;GO:0010033;GO:0055114;GO:0044700;GO:0009605;GO:0044707;GO:0034284;GO:0060255;GO:0048878;GO:0019538;GO:0009416;GO:0007165;GO:0034377;GO:0034375;GO:0022607;GO:0009892;GO:0015918;GO:0015850;GO:0009583;GO:0098754;GO:0050789;GO:0016043;GO:0065003;GO:0097006;GO:0065005;GO:0065008;GO:0006629;GO:0006810;GO:0051716;GO:0050794;GO:0008150;GO:0008152;GO:0042632;GO:0051234;GO:0051606;GO:0050896;GO:0034381;GO:0034384;GO:0006869;GO:0009314;GO:0030301;GO:0007154;GO:0044699;GO:0051248;GO:0051246;GO:1901700;GO:0032501;GO:0006721;GO:0006720;GO:0042161;GO:0042160;GO:0055088;GO:0048519;GO:0044255;GO:0009628;GO:0042592;GO:0043170;GO:0034380;GO:0042157;GO:0043933;GO:0031324;GO:0031323;GO:0050748;GO:0001523;GO:0050746;GO:0071825;GO:0071827;GO:0009636;GO:0071704;GO:0044085;GO:0071702;GO:0009581;GO:0009582;GO:0009987;GO:0009584;GO:0044765;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0009746;GO:0044238;GO:0009743;GO:0044237;GO:0009749;GO:0055092;GO:0048523; plasma lipoprotein particle oxidation;negative regulation of lipoprotein oxidation;fat-soluble vitamin metabolic process;negative regulation of plasma lipoprotein particle oxidation;regulation of primary metabolic process;regulation of metabolic process;cholesterol efflux;regulation of lipoprotein oxidation;small molecule metabolic process;cellular component organization or biogenesis;regulation of plasma lipoprotein particle oxidation;single-organism metabolic process;negative regulation of macromolecule metabolic process;cellular oxidant detoxification;diterpenoid metabolic process;biological regulation;macromolecule localization;vitamin metabolic process;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;phototransduction, visible light;phototransduction;cellular detoxification;signaling;reverse cholesterol transport;lipid localization;response to organic substance;oxidation-reduction process;single organism signaling;response to external stimulus;single-multicellular organism process;response to monosaccharide;regulation of macromolecule metabolic process;chemical homeostasis;protein metabolic process;response to light stimulus;signal transduction;plasma lipoprotein particle assembly;high-density lipoprotein particle remodeling;cellular component assembly;negative regulation of metabolic process;sterol transport;organic hydroxy compound transport;detection of light stimulus;detoxification;regulation of biological process;cellular component organization;macromolecular complex assembly;regulation of plasma lipoprotein particle levels;protein-lipid complex assembly;regulation of biological quality;lipid metabolic process;transport;cellular response to stimulus;regulation of cellular process;biological_process;metabolic process;cholesterol homeostasis;establishment of localization;detection of stimulus;response to stimulus;plasma lipoprotein particle clearance;high-density lipoprotein particle clearance;lipid transport;response to radiation;cholesterol transport;cell communication;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;response to oxygen-containing compound;multicellular organismal process;terpenoid metabolic process;isoprenoid metabolic process;lipoprotein oxidation;lipoprotein modification;lipid homeostasis;negative regulation of biological process;cellular lipid metabolic process;response to abiotic stimulus;homeostatic process;macromolecule metabolic process;high-density lipoprotein particle assembly;lipoprotein metabolic process;macromolecular complex subunit organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of lipoprotein metabolic process;retinoid metabolic process;regulation of lipoprotein metabolic process;protein-lipid complex subunit organization;plasma lipoprotein particle organization;response to toxic substance;organic substance metabolic process;cellular component biogenesis;organic substance transport;detection of external stimulus;detection of abiotic stimulus;cellular process;detection of visible light;single-organism transport;single-organism cellular process;response to chemical;localization;single-organism localization;response to hexose;primary metabolic process;response to carbohydrate;cellular metabolic process;response to glucose;sterol homeostasis;negative regulation of cellular process; 6;6;6;7;4;3;8;6;4;2;7;3;4;4;7;2;3;5;5;6;4;6;5;3;2;8;4;4;4;3;3;3;6;4;5;4;5;4;4;5;4;3;6;5;5;2;2;3;5;3;6;3;4;4;3;3;1;2;8;3;3;2;4;5;5;4;7;4;2;5;5;4;2;6;5;5;6;6;2;4;3;4;4;5;5;4;4;4;5;8;5;5;4;4;3;3;5;4;4;2;6;4;3;3;2;3;7;3;5;3;8;7;3; GO:0031982;GO:0016021;GO:0034361;GO:0034362;GO:0034364;GO:0034365;GO:0034366;GO:0043230;GO:0044421;GO:0043227;GO:0031224;GO:0044425;GO:0034385;GO:0016020;GO:1990777;GO:0031226;GO:0044459;GO:0032994;GO:0044464;GO:0005623;GO:0071944;GO:0034358;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576; vesicle;integral component of membrane;very-low-density lipoprotein particle;low-density lipoprotein particle;high-density lipoprotein particle;discoidal high-density lipoprotein particle;spherical high-density lipoprotein particle;extracellular organelle;extracellular region part;membrane-bounded organelle;intrinsic component of membrane;membrane part;triglyceride-rich lipoprotein particle;membrane;lipoprotein particle;intrinsic component of plasma membrane;plasma membrane part;protein-lipid complex;cell part;cell;cell periphery;plasma lipoprotein particle;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region; 4;4;5;4;4;5;5;3;2;3;3;2;4;2;4;4;3;3;2;2;3;3;4;2;4;3;3;3;2;1;2; GO:0005543;GO:0005319;GO:0016209;GO:0003674;GO:0005488;GO:0022892;GO:0043168;GO:0043167;GO:0008289;GO:0005215; phospholipid binding;lipid transporter activity;antioxidant activity;molecular_function;binding;substrate-specific transporter activity;anion binding;ion binding;lipid binding;transporter activity; 4;4;2;1;2;3;4;3;3;2; IPR022734;IPR012674; Apolipoprotein M;Calycin; extracellular Q86Y13 E3 ubiquitin-protein ligase DZIP3 OS=Homo sapiens OX=9606 GN=DZIP3 PE=1 SV=2 - [DZIP3_HUMAN] 1.086 1.164 0.883 1.268 0.987 0.521 0.932989691 0.473080146 1.284701114 0.735564572 0.758591065 0.100973517 0.527862209 0.054001708 GO:0010498;GO:0044237;GO:0044248;GO:0006511;GO:0043632;GO:0043170;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0071704;GO:0070647;GO:0000209;GO:0032446;GO:0042787;GO:0006508;GO:0051603;GO:0009987;GO:0019941;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0030163;GO:0008152;GO:0044257;GO:0009057;GO:0044238;GO:0019538;GO:0016567;GO:0043161;GO:0009056; proteasomal protein catabolic process;cellular metabolic process;cellular catabolic process;ubiquitin-dependent protein catabolic process;modification-dependent macromolecule catabolic process;macromolecule metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;organic substance metabolic process;protein modification by small protein conjugation or removal;protein polyubiquitination;protein modification by small protein conjugation;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;proteolysis;proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;protein catabolic process;metabolic process;cellular protein catabolic process;macromolecule catabolic process;primary metabolic process;protein metabolic process;protein ubiquitination;proteasome-mediated ubiquitin-dependent protein catabolic process;catabolic process; 6;3;4;8;6;4;5;4;5;4;3;7;10;8;9;5;6;2;7;6;5;5;1;5;2;6;5;3;4;9;7;3; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0043169;GO:0019899;GO:0003674;GO:0005488;GO:0003676;GO:0031593;GO:0032182;GO:1901363;GO:0004842;GO:0016740;GO:0043130;GO:0046872;GO:0019787;GO:0044822;GO:0003824;GO:0061630;GO:0061659;GO:0046914;GO:0043167;GO:0097159;GO:0016874;GO:0019902;GO:0003723;GO:0005515;GO:0008270; cation binding;enzyme binding;molecular_function;binding;nucleic acid binding;polyubiquitin binding;ubiquitin-like protein binding;heterocyclic compound binding;ubiquitin-protein transferase activity;transferase activity;ubiquitin binding;metal ion binding;ubiquitin-like protein transferase activity;poly(A) RNA binding;catalytic activity;ubiquitin protein ligase activity;ubiquitin-like protein ligase activity;transition metal ion binding;ion binding;organic cyclic compound binding;ligase activity;phosphatase binding;RNA binding;protein binding;zinc ion binding; 4;4;1;2;4;6;4;3;5;3;5;5;4;6;2;6;5;6;3;3;3;5;5;3;7; K10642 IPR033103;IPR001841;IPR013083; E3 ubiquitin-protein ligase DZIP3;Zinc finger, RING-type;Zinc finger, RING/FYVE/PHD-type; cytosol O75607 Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3 - [NPM3_HUMAN] 1.099 0.819 1.093 1.06 1.135 0.87 1.341880342 nan 0.933920705 nan 1.334554335 nan 0.766519824 nan GO:0032774;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:0034660;GO:1901362;GO:1901360;GO:1901576;GO:0044260;GO:0098781;GO:0071840;GO:0042254;GO:0071704;GO:0010467;GO:0097659;GO:0022613;GO:0018130;GO:0034470;GO:0006139;GO:0009987;GO:0006725;GO:0009303;GO:0006364;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0016072;GO:0044271;GO:0044237;GO:0043170;GO:0044085;GO:0006351;GO:0019438;GO:0006396; RNA biosynthetic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;ncRNA metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;ncRNA transcription;cellular component organization or biogenesis;ribosome biogenesis;organic substance metabolic process;gene expression;nucleic acid-templated transcription;ribonucleoprotein complex biogenesis;heterocycle biosynthetic process;ncRNA processing;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;rRNA transcription;rRNA processing;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;rRNA metabolic process;cellular nitrogen compound biosynthetic process;cellular metabolic process;macromolecule metabolic process;cellular component biogenesis;transcription, DNA-templated;aromatic compound biosynthetic process;RNA processing; 6;5;4;4;3;5;6;5;4;4;4;7;2;5;3;5;7;4;5;7;4;2;4;8;6;3;5;1;2;5;4;5;3;7;5;3;4;3;6;5;6; GO:0031974;GO:0043228;GO:0005622;GO:0044422;GO:0005623;GO:0043227;GO:0043226;GO:0005575;GO:0043229;GO:0043231;GO:0043232;GO:0043233;GO:0005730;GO:0044464;GO:0031981;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0005634; membrane-enclosed lumen;non-membrane-bounded organelle;intracellular;organelle part;cell;membrane-bounded organelle;organelle;cellular_component;intracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nucleolus;cell part;nuclear lumen;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;nucleus; 2;3;3;2;2;3;2;1;3;4;4;3;5;2;5;3;4;4;3;5; GO:0003674;GO:0005488;GO:1901363;GO:0003676;GO:0044822;GO:0097159;GO:0003723; molecular_function;binding;heterocyclic compound binding;nucleic acid binding;poly(A) RNA binding;organic cyclic compound binding;RNA binding; 1;2;3;4;6;3;5; K11278 IPR024057;IPR004301; Nucleoplasmin core domain;Nucleoplasmin family; extracellular Hs6857818 363.0 Y [Y] Nuclear structure; Q8IWB6 Inactive serine/threonine-protein kinase TEX14 OS=Homo sapiens OX=9606 GN=TEX14 PE=1 SV=2 - [TEX14_HUMAN] 1.072 1.061 0.955 1.129 1.122 0.596 1.010367578 nan 1.006238859 nan 0.900094251 nan 0.531194296 nan GO:0080090;GO:0032434;GO:0032435;GO:0044257;GO:0010965;GO:0071840;GO:0045786;GO:0000003;GO:1901799;GO:0044092;GO:0048519;GO:0007088;GO:0010605;GO:0060255;GO:0030162;GO:0030163;GO:1902099;GO:0000910;GO:0044702;GO:0010639;GO:0051783;GO:0019538;GO:0042177;GO:0051784;GO:0009056;GO:0045841;GO:0009894;GO:0098813;GO:0009892;GO:0051100;GO:0007067;GO:0043170;GO:0032091;GO:0007346;GO:0044265;GO:0044260;GO:0051782;GO:1903363;GO:0016043;GO:0051129;GO:0065007;GO:0007049;GO:0065009;GO:0071174;GO:0071173;GO:0051248;GO:0050794;GO:0043393;GO:0008152;GO:0051321;GO:1901988;GO:0051603;GO:1901987;GO:0010498;GO:0044784;GO:0006511;GO:0008150;GO:2001251;GO:0033044;GO:0033045;GO:0033046;GO:0033047;GO:0007140;GO:0033043;GO:0051246;GO:0033048;GO:0051128;GO:0044248;GO:0042176;GO:0009895;GO:1901991;GO:1901990;GO:0007059;GO:0044699;GO:0007126;GO:0043161;GO:0000280;GO:0006508;GO:0031330;GO:1903050;GO:0009987;GO:0019941;GO:0045839;GO:0051985;GO:0051983;GO:0044770;GO:0032269;GO:0032268;GO:0000819;GO:0051098;GO:0044772;GO:0030071;GO:0045861;GO:2000816;GO:0031329;GO:0031324;GO:0031323;GO:1903047;GO:1903046;GO:0008608;GO:0010948;GO:0022402;GO:0051306;GO:0043632;GO:0051304;GO:0051302;GO:0010564;GO:0050789;GO:0071704;GO:0051301;GO:0043063;GO:0043062;GO:0032465;GO:0032466;GO:0045930;GO:1903051;GO:0000278;GO:1903362;GO:0031577;GO:0061136;GO:1901575;GO:0022414;GO:0044763;GO:0019222;GO:0044267;GO:0009057;GO:0006996;GO:0044238;GO:0000070;GO:0051276;GO:0000075;GO:0051726;GO:0044237;GO:1902589;GO:0048285;GO:1902100;GO:0007094;GO:0007091;GO:0048523;GO:0007093; regulation of primary metabolic process;regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;cellular protein catabolic process;regulation of mitotic sister chromatid separation;cellular component organization or biogenesis;negative regulation of cell cycle;reproduction;negative regulation of proteasomal protein catabolic process;negative regulation of molecular function;negative regulation of biological process;regulation of mitotic nuclear division;negative regulation of macromolecule metabolic process;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;regulation of metaphase/anaphase transition of cell cycle;cytokinesis;single organism reproductive process;negative regulation of organelle organization;regulation of nuclear division;protein metabolic process;negative regulation of protein catabolic process;negative regulation of nuclear division;catabolic process;negative regulation of mitotic metaphase/anaphase transition;regulation of catabolic process;nuclear chromosome segregation;negative regulation of metabolic process;negative regulation of binding;mitotic nuclear division;macromolecule metabolic process;negative regulation of protein binding;regulation of mitotic cell cycle;cellular macromolecule catabolic process;cellular macromolecule metabolic process;negative regulation of cell division;negative regulation of cellular protein catabolic process;cellular component organization;negative regulation of cellular component organization;biological regulation;cell cycle;regulation of molecular function;mitotic spindle checkpoint;spindle assembly checkpoint;negative regulation of protein metabolic process;regulation of cellular process;regulation of protein binding;metabolic process;meiotic cell cycle;negative regulation of cell cycle phase transition;proteolysis involved in cellular protein catabolic process;regulation of cell cycle phase transition;proteasomal protein catabolic process;metaphase/anaphase transition of cell cycle;ubiquitin-dependent protein catabolic process;biological_process;negative regulation of chromosome organization;regulation of chromosome organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;male meiosis;regulation of organelle organization;regulation of protein metabolic process;negative regulation of mitotic sister chromatid segregation;regulation of cellular component organization;cellular catabolic process;regulation of protein catabolic process;negative regulation of catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;chromosome segregation;single-organism process;meiotic nuclear division;proteasome-mediated ubiquitin-dependent protein catabolic process;nuclear division;proteolysis;negative regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;negative regulation of mitotic nuclear division;negative regulation of chromosome segregation;regulation of chromosome segregation;cell cycle phase transition;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;sister chromatid segregation;regulation of binding;mitotic cell cycle phase transition;regulation of mitotic metaphase/anaphase transition;negative regulation of proteolysis;negative regulation of mitotic sister chromatid separation;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;meiotic cell cycle process;attachment of spindle microtubules to kinetochore;negative regulation of cell cycle process;cell cycle process;mitotic sister chromatid separation;modification-dependent macromolecule catabolic process;chromosome separation;regulation of cell division;regulation of cell cycle process;regulation of biological process;organic substance metabolic process;cell division;intercellular bridge organization;extracellular structure organization;regulation of cytokinesis;negative regulation of cytokinesis;negative regulation of mitotic cell cycle;negative regulation of proteolysis involved in cellular protein catabolic process;mitotic cell cycle;regulation of cellular protein catabolic process;spindle checkpoint;regulation of proteasomal protein catabolic process;organic substance catabolic process;reproductive process;single-organism cellular process;regulation of metabolic process;cellular protein metabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;mitotic sister chromatid segregation;chromosome organization;cell cycle checkpoint;regulation of cell cycle;cellular metabolic process;single-organism organelle organization;organelle fission;negative regulation of metaphase/anaphase transition of cell cycle;mitotic spindle assembly checkpoint;metaphase/anaphase transition of mitotic cell cycle;negative regulation of cellular process;mitotic cell cycle checkpoint; 4;8;8;6;7;2;4;2;7;4;2;6;4;4;6;5;6;5;3;5;5;4;5;5;3;7;4;5;3;5;5;4;6;5;5;4;4;6;3;4;2;4;3;6;7;5;3;5;2;3;6;6;6;6;6;8;1;6;6;5;5;6;5;5;5;6;4;4;5;4;6;6;4;2;4;7;6;5;5;7;2;7;6;4;4;5;5;5;5;4;6;7;6;7;5;4;4;5;4;5;5;4;6;6;5;4;5;2;3;4;5;4;5;5;5;7;5;6;6;7;4;2;3;3;5;5;4;3;6;5;5;4;3;4;5;7;6;6;3;6; GO:0000775;GO:0043234;GO:0043230;GO:0043232;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0044464;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0031982;GO:0044446;GO:0005737;GO:0045171;GO:0098687;GO:0000779;GO:0030496;GO:0005623;GO:0005622;GO:0070062;GO:0005694;GO:0000793;GO:1903561;GO:0000776;GO:0000777;GO:0032991;GO:0005575;GO:0005576; chromosome, centromeric region;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;intracellular part;chromosomal part;extracellular region part;organelle part;cell part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;vesicle;intracellular organelle part;cytoplasm;intercellular bridge;chromosomal region;condensed chromosome, centromeric region;midbody;cell;intracellular;extracellular exosome;chromosome;condensed chromosome;extracellular vesicle;kinetochore;condensed chromosome kinetochore;macromolecular complex;cellular_component;extracellular region; 6;3;3;4;3;4;2;2;2;3;3;3;2;4;3;4;3;5;7;3;2;3;4;5;6;3;4;5;2;1;2; GO:1901363;GO:0000166;GO:0016740;GO:0004672;GO:0019901;GO:0019900;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0016773;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0019899;GO:0043167;GO:0030554;GO:0005515;GO:0016772;GO:0001883;GO:0001882;GO:0036094; heterocyclic compound binding;nucleotide binding;transferase activity;protein kinase activity;protein kinase binding;kinase binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;enzyme binding;ion binding;adenyl nucleotide binding;protein binding;transferase activity, transferring phosphorus-containing groups;purine nucleoside binding;nucleoside binding;small molecule binding; 3;4;3;6;6;5;3;1;2;4;5;5;6;4;5;2;5;3;6;5;6;4;5;4;3;6;3;4;5;4;3; K17540 IPR002110;IPR020683;IPR001245;IPR011009;IPR000719; Ankyrin repeat;Ankyrin repeat-containing domain;Serine-threonine/tyrosine-protein kinase, catalytic domain;Protein kinase-like domain;Protein kinase domain; plasma membrane 377809771 68.2 M [M] Cell wall/membrane/envelope biogenesis; COG2815 PASTA domain, binds beta-lactams O75037 Kinesin-like protein KIF21B OS=Homo sapiens OX=9606 GN=KIF21B PE=1 SV=2 - [KI21B_HUMAN] 1.346 0.917 0.937 0.951 1.014 1 1.46782988 nan 0.937869822 nan 1.021810251 nan 0.986193294 nan GO:0006928;GO:0044699;GO:0009987;GO:0008150;GO:0007017;GO:0007018;GO:0044763; movement of cell or subcellular component;single-organism process;cellular process;biological_process;microtubule-based process;microtubule-based movement;single-organism cellular process; 4;2;2;1;4;5;3; GO:0099512;GO:0099513;GO:0044464;GO:0043229;GO:0043228;GO:0005871;GO:0005874;GO:0005875;GO:0005737;GO:0044446;GO:0043226;GO:0044430;GO:0015630;GO:0043234;GO:0032991;GO:0043232;GO:0005856;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;cell part;intracellular organelle;non-membrane-bounded organelle;kinesin complex;microtubule;microtubule associated complex;cytoplasm;intracellular organelle part;organelle;cytoskeletal part;microtubule cytoskeleton;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cytoskeleton;cell;intracellular;cellular_component;intracellular part;organelle part; 2;3;2;3;3;5;4;4;4;3;2;4;6;3;2;4;5;2;3;1;3;2; GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0016887;GO:0005524;GO:0001883;GO:0043167;GO:0001882;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0016787;GO:0000166;GO:0017111;GO:0036094;GO:0003824;GO:0032555;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032550;GO:0032559;GO:0032553;GO:0043168; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;ATPase activity;ATP binding;purine nucleoside binding;ion binding;nucleoside binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;hydrolase activity;nucleotide binding;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;purine ribonucleoside binding;adenyl ribonucleotide binding;ribonucleotide binding;anion binding; 5;3;1;2;8;6;5;3;4;4;5;5;8;9;3;4;7;3;2;5;5;6;3;3;4;6;6;6;4;4; K10395 IPR017986;IPR001680;IPR019821;IPR015943;IPR019775;IPR001752;IPR027417; WD40-repeat-containing domain;WD40 repeat;Kinesin motor domain, conserved site;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;Kinesin motor domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs22059543 916.0 Z [Z] Cytoskeleton; Q92185 Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase OS=Homo sapiens OX=9606 GN=ST8SIA1 PE=1 SV=1 - [SIA8A_HUMAN] 1.102 1.259 0.734 0.946 1.368 0.413 0.875297855 nan 0.691520468 nan 0.583002383 nan 0.301900585 nan GO:0044238;GO:0034605;GO:0044710;GO:0044711;GO:0018193;GO:0048518;GO:0006664;GO:0006665;GO:0006687;GO:0042127;GO:1901564;GO:1901566;GO:0019538;GO:0033554;GO:0006807;GO:0043170;GO:1901576;GO:0044260;GO:0065007;GO:0006688;GO:0030148;GO:0006629;GO:0051716;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0009266;GO:0044723;GO:0050896;GO:0043412;GO:0043413;GO:0018196;GO:0044249;GO:0034645;GO:0044699;GO:0046467;GO:0008284;GO:1903509;GO:0006643;GO:0008283;GO:0043687;GO:0009987;GO:0009247;GO:0009408;GO:0044255;GO:1901137;GO:1901135;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0006488;GO:0050789;GO:0071704;GO:0018279;GO:0044267;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0008610;GO:0009628;GO:0005975;GO:0006490;GO:0044237;GO:0048522; primary metabolic process;cellular response to heat;single-organism metabolic process;single-organism biosynthetic process;peptidyl-amino acid modification;positive regulation of biological process;glycolipid metabolic process;sphingolipid metabolic process;glycosphingolipid metabolic process;regulation of cell proliferation;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular response to stress;nitrogen compound metabolic process;macromolecule metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;glycosphingolipid biosynthetic process;sphingolipid biosynthetic process;lipid metabolic process;cellular response to stimulus;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;response to temperature stimulus;single-organism carbohydrate metabolic process;response to stimulus;macromolecule modification;macromolecule glycosylation;peptidyl-asparagine modification;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;membrane lipid biosynthetic process;positive regulation of cell proliferation;liposaccharide metabolic process;membrane lipid metabolic process;cell proliferation;post-translational protein modification;cellular process;glycolipid biosynthetic process;response to heat;cellular lipid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;dolichol-linked oligosaccharide biosynthetic process;regulation of biological process;organic substance metabolic process;protein N-linked glycosylation via asparagine;cellular protein metabolic process;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;lipid biosynthetic process;response to abiotic stimulus;carbohydrate metabolic process;oligosaccharide-lipid intermediate biosynthetic process;cellular metabolic process;positive regulation of cellular process; 3;5;3;4;7;2;6;5;6;4;4;5;4;4;3;4;4;4;2;7;6;4;3;3;3;5;1;2;4;4;2;5;6;8;4;5;2;5;4;5;5;3;7;2;6;4;4;5;4;5;6;4;5;6;2;3;6;5;5;6;3;5;3;5;3;4;5;3;3; GO:0016021;GO:0016020;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0030173;GO:0043227;GO:0043226;GO:0044431;GO:0031224;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0031228;GO:0031301;GO:0031300;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0005575; integral component of membrane;membrane;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;integral component of Golgi membrane;membrane-bounded organelle;organelle;Golgi apparatus part;intrinsic component of membrane;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intrinsic component of Golgi membrane;integral component of organelle membrane;intrinsic component of organelle membrane;cytoplasm;organelle membrane;cell part;cell;intracellular;cellular_component; 4;2;4;4;4;3;2;2;3;5;3;2;4;3;3;5;3;4;4;4;3;4;3;2;2;3;1; GO:0008373;GO:0016740;GO:0003674;GO:0003824;GO:0003828;GO:0016757; sialyltransferase activity;transferase activity;molecular_function;catalytic activity;alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;transferase activity, transferring glycosyl groups; 5;3;1;2;6;4; K03371 map00601;map00603;map00604;map01100; Glycosphingolipid biosynthesis - lacto and neolacto series;Glycosphingolipid biosynthesis - globo series;Glycosphingolipid biosynthesis - ganglio series;Metabolic pathways; IPR012163;IPR001675; Sialyltransferase;Glycosyl transferase family 29; mitochondria Hs4506953 750.0 G [G] Carbohydrate transport and metabolism; P01714 Immunoglobulin lambda variable 3-19 OS=Homo sapiens OX=9606 GN=IGLV3-19 PE=1 SV=2 - [LV319_HUMAN] 0.966 0.956 1.205 0.918 1.02 0.775 1.010460251 0.510060592 0.9 0.772984015 1.260460251 0.006149738 0.759803922 0.292411115 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9UHH9 Inositol hexakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=IP6K2 PE=1 SV=2 - [IP6K2_HUMAN] 0.983 1.275 0.669 1.198 1.174 1.046 0.770980392 nan 1.02044293 nan 0.524705882 nan 0.890971039 nan GO:0019221;GO:0006820;GO:0044281;GO:0007166;GO:0071840;GO:0044710;GO:0071310;GO:0048518;GO:0048519;GO:0046488;GO:0046486;GO:0010033;GO:0044700;GO:0043647;GO:0002376;GO:0019637;GO:0007165;GO:0042981;GO:0050789;GO:0034097;GO:0016049;GO:0071357;GO:0016043;GO:0065007;GO:0046854;GO:0006629;GO:0006811;GO:0006810;GO:0006817;GO:0051716;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0051234;GO:0050896;GO:1901615;GO:0030308;GO:0016310;GO:0051128;GO:0023052;GO:0070887;GO:0007154;GO:0044699;GO:0046834;GO:0006644;GO:0009987;GO:0001558;GO:0044255;GO:0030258;GO:0071345;GO:0045926;GO:0006650;GO:0019751;GO:0010942;GO:0008219;GO:0010941;GO:0040007;GO:0040008;GO:0043065;GO:0071704;GO:0043067;GO:0015698;GO:0043068;GO:0045087;GO:0006915;GO:0034340;GO:0044765;GO:0044763;GO:0060337;GO:0042221;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0006066;GO:0006796;GO:0006793;GO:0048523;GO:0048522; cytokine-mediated signaling pathway;anion transport;small molecule metabolic process;cell surface receptor signaling pathway;cellular component organization or biogenesis;single-organism metabolic process;cellular response to organic substance;positive regulation of biological process;negative regulation of biological process;phosphatidylinositol metabolic process;glycerolipid metabolic process;response to organic substance;single organism signaling;inositol phosphate metabolic process;immune system process;organophosphate metabolic process;signal transduction;regulation of apoptotic process;regulation of biological process;response to cytokine;cell growth;cellular response to type I interferon;cellular component organization;biological regulation;phosphatidylinositol phosphorylation;lipid metabolic process;ion transport;transport;phosphate ion transport;cellular response to stimulus;regulation of cellular process;defense response;programmed cell death;response to stress;biological_process;metabolic process;immune response;establishment of localization;response to stimulus;organic hydroxy compound metabolic process;negative regulation of cell growth;phosphorylation;regulation of cellular component organization;signaling;cellular response to chemical stimulus;cell communication;single-organism process;lipid phosphorylation;phospholipid metabolic process;cellular process;regulation of cell growth;cellular lipid metabolic process;lipid modification;cellular response to cytokine stimulus;negative regulation of growth;glycerophospholipid metabolic process;polyol metabolic process;positive regulation of cell death;cell death;regulation of cell death;growth;regulation of growth;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;inorganic anion transport;positive regulation of programmed cell death;innate immune response;apoptotic process;response to type I interferon;single-organism transport;single-organism cellular process;type I interferon signaling pathway;response to chemical;localization;single-organism localization;primary metabolic process;cellular metabolic process;alcohol metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process; 6;6;4;5;2;3;5;2;2;7;5;4;3;4;2;4;4;6;2;5;3;6;3;2;7;4;5;4;8;3;3;4;5;3;1;2;3;3;2;4;4;6;4;2;4;4;2;6;5;2;4;4;5;6;3;6;6;4;4;4;2;3;6;3;5;7;5;4;6;5;4;3;7;3;2;3;3;3;5;5;4;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044422;GO:0043229;GO:0043228;GO:0005856;GO:0045111;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0044424;GO:0005575;GO:0043227;GO:0043226;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;organelle part;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;intermediate filament cytoskeleton;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;intracellular;intracellular part;cellular_component;membrane-bounded organelle;organelle;intracellular organelle lumen; 2;5;4;4;3;4;2;3;3;5;6;5;3;5;2;2;3;3;1;3;2;4; GO:1901363;GO:0000166;GO:0016740;GO:0032549;GO:0052723;GO:0052724;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0017076;GO:0005524;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0016776;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0051766;GO:0043167;GO:0030554;GO:0097159;GO:0001883;GO:0001882;GO:0008440;GO:0000828;GO:0036094;GO:0000832; heterocyclic compound binding;nucleotide binding;transferase activity;ribonucleoside binding;inositol hexakisphosphate 1-kinase activity;inositol hexakisphosphate 3-kinase activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;purine nucleotide binding;ATP binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;phosphotransferase activity, phosphate group as acceptor;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;inositol trisphosphate kinase activity;ion binding;adenyl nucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;inositol-1,4,5-trisphosphate 3-kinase activity;inositol hexakisphosphate kinase activity;small molecule binding;inositol hexakisphosphate 5-kinase activity; 3;4;3;5;7;7;3;1;2;4;5;6;5;2;5;4;5;6;5;6;4;5;4;6;3;6;3;5;4;7;6;3;7; K07756 map04070; Phosphatidylinositol signaling system; IPR005522; Inositol polyphosphate kinase; cytosol Hs14736134 890.0 KIT [K] Transcription;[I] Lipid transport and metabolism;[T] Signal transduction mechanisms; A0M8Q6 Immunoglobulin lambda constant 7 OS=Homo sapiens OX=9606 GN=IGLC7 PE=1 SV=3 - [IGLC7_HUMAN] 0.92 1.207 0.852 0.875 1.327 0.425 0.762220381 0.00928763 0.659382065 0.932642438 0.705882353 0.015612378 0.320271289 0.034208074 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0048518;GO:0002682;GO:0019724;GO:0046649;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0009607;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0050789;GO:0002764;GO:0002431;GO:0002768;GO:0002433;GO:0016043;GO:0002684;GO:0065007;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0006956;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0038096;GO:0038094;GO:0038095;GO:0006897;GO:0038093;GO:0050896;GO:0006898;GO:0001775;GO:0042742;GO:0002694;GO:0002696;GO:0008150;GO:0009617;GO:0023052;GO:0044699;GO:0051234;GO:0008037;GO:0009987;GO:0050871;GO:0002757;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0072376;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0002443;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;lymphocyte activation;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;response to biotic stimulus;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;cellular component organization;positive regulation of immune system process;biological regulation;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;complement activation;metabolic process;immune response;complement activation, classical pathway;humoral immune response;Fc-gamma receptor signaling pathway involved in phagocytosis;Fc-gamma receptor signaling pathway;Fc-epsilon receptor signaling pathway;endocytosis;Fc receptor signaling pathway;response to stimulus;receptor-mediated endocytosis;cell activation;defense response to bacterium;regulation of leukocyte activation;positive regulation of leukocyte activation;biological_process;response to bacterium;signaling;single-organism process;establishment of localization;cell recognition;cellular process;positive regulation of B cell activation;immune response-activating signal transduction;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;protein activation cascade;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;leukocyte mediated immunity;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;2;3;6;4;3;2;3;5;3;5;3;4;2;3;2;5;6;6;4;3;3;2;4;3;3;4;3;7;4;2;3;5;4;5;8;8;6;7;2;7;4;5;4;4;1;4;2;2;3;4;2;6;4;4;4;5;5;4;5;4;4;6;4;5;3;3;6;7;4;5;6;5;4;3;4;4;2;3;3;4;3;3;5;3; GO:0016020;GO:0043234;GO:0044425;GO:0044421;GO:0009897;GO:0005623;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0005615;GO:0005886;GO:0032991;GO:0005575;GO:0005576;GO:0072562; membrane;protein complex;membrane part;extracellular region part;external side of plasma membrane;cell;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular space;plasma membrane;macromolecular complex;cellular_component;extracellular region;blood microparticle; 2;3;2;2;4;2;3;4;3;3;2;3;3;3;3;2;1;2;3; GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102;GO:0005488; molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding;binding; 1;5;3;3;4;2; IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular P05090 Apolipoprotein D OS=Homo sapiens OX=9606 GN=APOD PE=1 SV=1 - [APOD_HUMAN] 0.876 1.177 0.968 0.903 1.215 0.921 0.744265081 2.56E-33 0.743209877 4.16E-22 0.822429907 2.84E-08 0.758024691 0.189670435 GO:0032880;GO:0033157;GO:0051169;GO:0008104;GO:0048589;GO:0034440;GO:0051049;GO:0048585;GO:0032387;GO:0048583;GO:0048678;GO:0007160;GO:0031348;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0007167;GO:0051893;GO:0007169;GO:0051895;GO:0034443;GO:0051716;GO:0010605;GO:0061302;GO:0009968;GO:0071704;GO:0009966;GO:0048869;GO:0042160;GO:0032101;GO:0009611;GO:0006979;GO:1904590;GO:0045833;GO:0048514;GO:0048519;GO:0031324;GO:0033036;GO:0032602;GO:0032386;GO:2000405;GO:0031589;GO:0031103;GO:0031102;GO:1901889;GO:1901888;GO:0060255;GO:0048468;GO:2000098;GO:0006605;GO:0045184;GO:0042221;GO:0034439;GO:0042493;GO:0010876;GO:0055114;GO:0044700;GO:0044707;GO:0048870;GO:0019538;GO:0042246;GO:0007162;GO:0002376;GO:0033002;GO:0060322;GO:0033554;GO:0005996;GO:0044281;GO:0044710;GO:0022607;GO:0009892;GO:0030336;GO:1903650;GO:1900180;GO:0051051;GO:0006928;GO:0051271;GO:1903392;GO:0002532;GO:0051223;GO:0001816;GO:0010646;GO:0048660;GO:0014012;GO:0001568;GO:0000302;GO:0016043;GO:0090109;GO:0002686;GO:2000401;GO:2000402;GO:0002685;GO:0065007;GO:0071840;GO:0016477;GO:0048646;GO:0070201;GO:0051246;GO:0061564;GO:0006629;GO:1903649;GO:0006810;GO:0019318;GO:0009888;GO:0042060;GO:0050794;GO:0006952;GO:1904589;GO:0006950;GO:0008150;GO:0008152;GO:0048731;GO:0044723;GO:0042306;GO:0050728;GO:0051234;GO:0072678;GO:0042308;GO:1900181;GO:2000404;GO:0046907;GO:0050896;GO:0070727;GO:0019222;GO:0072676;GO:0072594;GO:0034442;GO:2000145;GO:0046823;GO:0048008;GO:2000146;GO:0051170;GO:1900015;GO:0032642;GO:0032682;GO:0002534;GO:0032102;GO:0006954;GO:0006869;GO:0001944;GO:0030155;GO:0030154;GO:0051129;GO:0051128;GO:1903827;GO:0023057;GO:0007045;GO:0007044;GO:0023052;GO:0010648;GO:1903533;GO:0023051;GO:0001953;GO:1904950;GO:0009653;GO:0010640;GO:0044699;GO:0010642;GO:0007420;GO:0051248;GO:0051241;GO:0031099;GO:0051641;GO:0030030;GO:0048513;GO:0022610;GO:0031175;GO:1903035;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0042161;GO:0009987;GO:0050727;GO:0060588;GO:0060587;GO:0051270;GO:0017038;GO:0045216;GO:0071605;GO:0044744;GO:0044255;GO:0032879;GO:0030258;GO:0034329;GO:0051239;GO:0016482;GO:1900016;GO:0007568;GO:1901700;GO:0001952;GO:1903828;GO:0001817;GO:0051674;GO:0033365;GO:1903391;GO:0006006;GO:0080134;GO:0001818;GO:0042157;GO:0034504;GO:0042127;GO:0060341;GO:0034333;GO:0034332;GO:0034330;GO:0031323;GO:0071638;GO:0050748;GO:0040013;GO:0050900;GO:0048041;GO:2000097;GO:0001525;GO:0007275;GO:0050746;GO:0080090;GO:0007417;GO:0002682;GO:0040007;GO:1903034;GO:0051224;GO:1902593;GO:0050789;GO:0071702;GO:0046822;GO:0009605;GO:0048666;GO:0002683;GO:0030334;GO:0048662;GO:0048659;GO:0030182;GO:0019216;GO:0010810;GO:0006606;GO:0010812;GO:0034613;GO:0090317;GO:0006913;GO:0043170;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0007155;GO:0007154;GO:0022008;GO:0051179;GO:1902578;GO:0040011;GO:0044238;GO:0048699;GO:0040012;GO:0007399;GO:0005975;GO:0048856;GO:0044237;GO:0044087;GO:0044085;GO:0071637;GO:0015031;GO:1902582;GO:0031347;GO:1902580;GO:0006886;GO:0048523; regulation of protein localization;regulation of intracellular protein transport;nuclear transport;protein localization;developmental growth;lipid oxidation;regulation of transport;negative regulation of response to stimulus;negative regulation of intracellular transport;regulation of response to stimulus;response to axon injury;cell-matrix adhesion;negative regulation of defense response;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of focal adhesion assembly;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of focal adhesion assembly;negative regulation of lipoprotein oxidation;cellular response to stimulus;negative regulation of macromolecule metabolic process;smooth muscle cell-matrix adhesion;negative regulation of signal transduction;organic substance metabolic process;regulation of signal transduction;cellular developmental process;lipoprotein modification;regulation of response to external stimulus;response to wounding;response to oxidative stress;negative regulation of protein import;negative regulation of lipid metabolic process;blood vessel morphogenesis;negative regulation of biological process;negative regulation of cellular metabolic process;macromolecule localization;chemokine production;regulation of intracellular transport;negative regulation of T cell migration;cell-substrate adhesion;axon regeneration;neuron projection regeneration;negative regulation of cell junction assembly;regulation of cell junction assembly;regulation of macromolecule metabolic process;cell development;negative regulation of smooth muscle cell-matrix adhesion;protein targeting;establishment of protein localization;response to chemical;lipoprotein lipid oxidation;response to drug;lipid localization;oxidation-reduction process;single organism signaling;single-multicellular organism process;cell motility;protein metabolic process;tissue regeneration;negative regulation of cell adhesion;immune system process;muscle cell proliferation;head development;cellular response to stress;monosaccharide metabolic process;small molecule metabolic process;single-organism metabolic process;cellular component assembly;negative regulation of metabolic process;negative regulation of cell migration;negative regulation of cytoplasmic transport;regulation of protein localization to nucleus;negative regulation of transport;movement of cell or subcellular component;negative regulation of cellular component movement;negative regulation of adherens junction organization;production of molecular mediator involved in inflammatory response;regulation of protein transport;cytokine production;regulation of cell communication;regulation of smooth muscle cell proliferation;peripheral nervous system axon regeneration;blood vessel development;response to reactive oxygen species;cellular component organization;regulation of cell-substrate junction assembly;negative regulation of leukocyte migration;regulation of lymphocyte migration;negative regulation of lymphocyte migration;regulation of leukocyte migration;biological regulation;cellular component organization or biogenesis;cell migration;anatomical structure formation involved in morphogenesis;regulation of establishment of protein localization;regulation of protein metabolic process;axon development;lipid metabolic process;regulation of cytoplasmic transport;transport;hexose metabolic process;tissue development;wound healing;regulation of cellular process;defense response;regulation of protein import;response to stress;biological_process;metabolic process;system development;single-organism carbohydrate metabolic process;regulation of protein import into nucleus;negative regulation of inflammatory response;establishment of localization;T cell migration;negative regulation of protein import into nucleus;negative regulation of protein localization to nucleus;regulation of T cell migration;intracellular transport;response to stimulus;cellular macromolecule localization;regulation of metabolic process;lymphocyte migration;establishment of protein localization to organelle;regulation of lipoprotein oxidation;regulation of cell motility;negative regulation of nucleocytoplasmic transport;platelet-derived growth factor receptor signaling pathway;negative regulation of cell motility;nuclear import;regulation of cytokine production involved in inflammatory response;regulation of chemokine production;negative regulation of chemokine production;cytokine production involved in inflammatory response;negative regulation of response to external stimulus;inflammatory response;lipid transport;vasculature development;regulation of cell adhesion;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;negative regulation of signaling;cell-substrate adherens junction assembly;cell-substrate junction assembly;signaling;negative regulation of cell communication;regulation of protein targeting;regulation of signaling;negative regulation of cell-matrix adhesion;negative regulation of establishment of protein localization;anatomical structure morphogenesis;regulation of platelet-derived growth factor receptor signaling pathway;single-organism process;negative regulation of platelet-derived growth factor receptor signaling pathway;brain development;negative regulation of protein metabolic process;negative regulation of multicellular organismal process;regeneration;cellular localization;cell projection organization;animal organ development;biological adhesion;neuron projection development;negative regulation of response to wounding;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;lipoprotein oxidation;cellular process;regulation of inflammatory response;negative regulation of lipoprotein lipid oxidation;regulation of lipoprotein lipid oxidation;regulation of cellular component movement;protein import;cell-cell junction organization;monocyte chemotactic protein-1 production;protein targeting to nucleus;cellular lipid metabolic process;regulation of localization;lipid modification;cell junction assembly;regulation of multicellular organismal process;cytosolic transport;negative regulation of cytokine production involved in inflammatory response;aging;response to oxygen-containing compound;regulation of cell-matrix adhesion;negative regulation of cellular protein localization;regulation of cytokine production;localization of cell;protein localization to organelle;regulation of adherens junction organization;glucose metabolic process;regulation of response to stress;negative regulation of cytokine production;lipoprotein metabolic process;protein localization to nucleus;regulation of cell proliferation;regulation of cellular localization;adherens junction assembly;adherens junction organization;cell junction organization;regulation of cellular metabolic process;negative regulation of monocyte chemotactic protein-1 production;negative regulation of lipoprotein metabolic process;negative regulation of locomotion;leukocyte migration;focal adhesion assembly;regulation of smooth muscle cell-matrix adhesion;angiogenesis;multicellular organism development;regulation of lipoprotein metabolic process;regulation of primary metabolic process;central nervous system development;regulation of immune system process;growth;regulation of response to wounding;negative regulation of protein transport;single-organism nuclear import;regulation of biological process;organic substance transport;regulation of nucleocytoplasmic transport;response to external stimulus;neuron development;negative regulation of immune system process;regulation of cell migration;negative regulation of smooth muscle cell proliferation;smooth muscle cell proliferation;neuron differentiation;regulation of lipid metabolic process;regulation of cell-substrate adhesion;protein import into nucleus;negative regulation of cell-substrate adhesion;cellular protein localization;negative regulation of intracellular protein transport;nucleocytoplasmic transport;macromolecule metabolic process;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;cell adhesion;cell communication;neurogenesis;localization;single-organism localization;locomotion;primary metabolic process;generation of neurons;regulation of locomotion;nervous system development;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;regulation of cellular component biogenesis;cellular component biogenesis;regulation of monocyte chemotactic protein-1 production;protein transport;single-organism intracellular transport;regulation of defense response;single-organism cellular localization;intracellular protein transport;negative regulation of cellular process; 4;6;6;4;3;5;4;3;4;3;5;5;4;5;5;4;5;6;6;7;6;6;3;4;6;4;3;4;4;6;4;4;4;5;4;4;2;4;3;5;5;6;4;6;5;5;4;4;4;7;6;4;3;6;4;4;4;3;3;3;4;4;4;2;4;4;4;5;4;3;4;3;5;5;6;3;4;4;5;4;5;4;4;5;7;4;5;3;5;4;5;5;4;2;2;4;3;5;5;6;4;6;4;6;4;5;3;4;6;3;1;2;4;4;6;5;3;5;5;4;6;5;2;4;3;4;5;6;4;6;8;4;8;5;5;5;5;4;5;5;5;4;5;4;4;5;3;7;6;2;4;7;3;6;3;3;5;2;5;4;5;3;4;3;4;4;2;5;4;2;4;2;3;5;2;5;5;6;4;5;5;6;5;4;3;5;5;3;6;5;4;4;6;3;4;3;6;5;7;4;4;5;7;4;4;6;6;4;4;6;5;3;3;6;7;4;4;5;4;5;3;2;5;4;6;2;5;7;3;5;3;5;5;5;6;5;5;5;5;5;4;7;4;3;4;3;4;3;4;6;2;3;2;3;7;3;5;4;3;3;3;3;6;5;5;5;4;6;3; GO:0022626;GO:0005783;GO:0030425;GO:0030529;GO:0044297;GO:0036477;GO:0042995;GO:0043231;GO:0043230;GO:0005829;GO:0044424;GO:0044421;GO:0044464;GO:0043232;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0048471;GO:0043025;GO:0012505;GO:0031982;GO:0005840;GO:0044444;GO:0044445;GO:0005737;GO:0043005;GO:0070062;GO:1990904;GO:0005623;GO:0005622;GO:0097458;GO:0005576;GO:1903561;GO:0005615;GO:0032991;GO:0005575; cytosolic ribosome;endoplasmic reticulum;dendrite;intracellular ribonucleoprotein complex;cell body;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;extracellular organelle;cytosol;intracellular part;extracellular region part;cell part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;perinuclear region of cytoplasm;neuronal cell body;endomembrane system;vesicle;ribosome;cytoplasmic part;cytosolic part;cytoplasm;neuron projection;extracellular exosome;ribonucleoprotein complex;cell;intracellular;neuron part;extracellular region;extracellular vesicle;extracellular space;macromolecular complex;cellular_component; 6;4;5;4;3;4;3;4;3;5;3;2;2;4;3;3;3;2;5;4;3;4;5;4;5;4;4;4;3;2;3;3;2;3;3;2;1; GO:0005319;GO:0032934;GO:0005496;GO:0015485;GO:0003674;GO:0005488;GO:0022892;GO:0036094;GO:0097159;GO:0005215;GO:0008289;GO:0043178; lipid transporter activity;sterol binding;steroid binding;cholesterol binding;molecular_function;binding;substrate-specific transporter activity;small molecule binding;organic cyclic compound binding;transporter activity;lipid binding;alcohol binding; 4;5;4;6;1;2;3;3;3;2;3;4; K03098 IPR002345;IPR022271;IPR002969;IPR000566;IPR026222;IPR012674;IPR022272; Lipocalin;Lipocalin, ApoD type;Apolipoprotein D;Lipocalin/cytosolic fatty-acid binding domain;Apolipoprotein D, vertebrates;Calycin;Lipocalin family conserved site; extracellular Hs4502163 393.0 M [M] Cell wall/membrane/envelope biogenesis; P07205 Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3 - [PGK2_HUMAN] 0.913 0.763 0.793 0.727 0.703 5.468 1.196592398 nan 1.034139403 nan 1.03931848 nan 7.778093883 nan GO:0098779;GO:0009167;GO:0044281;GO:0009161;GO:0007005;GO:0044712;GO:0044710;GO:0046128;GO:0006733;GO:0009205;GO:0046034;GO:0046031;GO:0032787;GO:0043436;GO:1901564;GO:0009179;GO:0046483;GO:0048870;GO:0016052;GO:0006163;GO:0033554;GO:0009141;GO:0009144;GO:1903008;GO:0006928;GO:0006807;GO:0046496;GO:1901575;GO:0009199;GO:0016043;GO:0071840;GO:0019637;GO:0006165;GO:0051716;GO:0009150;GO:0006950;GO:0008150;GO:0008152;GO:0044723;GO:0044724;GO:0050896;GO:0022411;GO:0006753;GO:0006757;GO:0006732;GO:0016310;GO:0009117;GO:0046939;GO:0034641;GO:0009123;GO:0009126;GO:0009259;GO:0044699;GO:0006139;GO:0042278;GO:0006996;GO:0030317;GO:0009987;GO:0006725;GO:0009132;GO:0009135;GO:0055086;GO:0000422;GO:0000423;GO:1901135;GO:0051674;GO:0009185;GO:0016236;GO:0019752;GO:0019693;GO:0072521;GO:0006091;GO:0006090;GO:0072524;GO:0006096;GO:1901360;GO:0006796;GO:0098780;GO:0071704;GO:0006082;GO:0061726;GO:0006914;GO:0051186;GO:0044763;GO:0009116;GO:0009119;GO:0009056;GO:0051179;GO:0040011;GO:0044238;GO:0005975;GO:0044237;GO:1901657;GO:1902589;GO:0006793;GO:0019362; mitophagy in response to mitochondrial depolarization;purine ribonucleoside monophosphate metabolic process;small molecule metabolic process;ribonucleoside monophosphate metabolic process;mitochondrion organization;single-organism catabolic process;single-organism metabolic process;purine ribonucleoside metabolic process;oxidoreduction coenzyme metabolic process;purine ribonucleoside triphosphate metabolic process;ATP metabolic process;ADP metabolic process;monocarboxylic acid metabolic process;oxoacid metabolic process;organonitrogen compound metabolic process;purine ribonucleoside diphosphate metabolic process;heterocycle metabolic process;cell motility;carbohydrate catabolic process;purine nucleotide metabolic process;cellular response to stress;nucleoside triphosphate metabolic process;purine nucleoside triphosphate metabolic process;organelle disassembly;movement of cell or subcellular component;nitrogen compound metabolic process;nicotinamide nucleotide metabolic process;organic substance catabolic process;ribonucleoside triphosphate metabolic process;cellular component organization;cellular component organization or biogenesis;organophosphate metabolic process;nucleoside diphosphate phosphorylation;cellular response to stimulus;purine ribonucleotide metabolic process;response to stress;biological_process;metabolic process;single-organism carbohydrate metabolic process;single-organism carbohydrate catabolic process;response to stimulus;cellular component disassembly;nucleoside phosphate metabolic process;ATP generation from ADP;coenzyme metabolic process;phosphorylation;nucleotide metabolic process;nucleotide phosphorylation;cellular nitrogen compound metabolic process;nucleoside monophosphate metabolic process;purine nucleoside monophosphate metabolic process;ribonucleotide metabolic process;single-organism process;nucleobase-containing compound metabolic process;purine nucleoside metabolic process;organelle organization;sperm motility;cellular process;cellular aromatic compound metabolic process;nucleoside diphosphate metabolic process;purine nucleoside diphosphate metabolic process;nucleobase-containing small molecule metabolic process;mitophagy;macromitophagy;carbohydrate derivative metabolic process;localization of cell;ribonucleoside diphosphate metabolic process;macroautophagy;carboxylic acid metabolic process;ribose phosphate metabolic process;purine-containing compound metabolic process;generation of precursor metabolites and energy;pyruvate metabolic process;pyridine-containing compound metabolic process;glycolytic process;organic cyclic compound metabolic process;phosphate-containing compound metabolic process;response to mitochondrial depolarisation;organic substance metabolic process;organic acid metabolic process;mitochondrion disassembly;autophagy;cofactor metabolic process;single-organism cellular process;nucleoside metabolic process;ribonucleoside metabolic process;catabolic process;localization;locomotion;primary metabolic process;carbohydrate metabolic process;cellular metabolic process;glycosyl compound metabolic process;single-organism organelle organization;phosphorus metabolic process;pyridine nucleotide metabolic process; 6;8;4;7;5;4;3;7;6;8;8;8;7;5;4;8;4;3;5;6;4;6;7;5;4;3;7;4;7;3;2;4;7;3;7;3;1;2;4;5;2;4;5;5;5;6;6;7;4;6;7;6;2;4;6;4;4;2;4;6;7;4;4;5;4;3;7;4;6;5;5;4;8;5;6;4;5;5;3;4;6;3;4;3;5;6;3;2;2;3;4;3;4;4;4;6; GO:0031982;GO:0031514;GO:0042995;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005929;GO:0043227;GO:0043226;GO:0044441;GO:0036126;GO:0005737;GO:0005634;GO:0097223;GO:0035686;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:1903561;GO:0005575;GO:0005576; vesicle;motile cilium;cell projection;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;cilium;membrane-bounded organelle;organelle;ciliary part;sperm flagellum;cytoplasm;nucleus;sperm part;sperm fibrous sheath;cell projection part;cell part;cell;intracellular;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;4;3;3;4;3;2;2;3;3;3;2;3;4;4;5;3;4;3;2;2;3;4;3;1;2; GO:1901363;GO:0000166;GO:0035639;GO:0016740;GO:0017076;GO:0097367;GO:0030554;GO:0003674;GO:1901265;GO:0032549;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0016772;GO:0016774;GO:0032559;GO:0032555;GO:0032553;GO:0043167;GO:0004618;GO:0097159;GO:0005488;GO:0001883;GO:0001882;GO:0036094;GO:0032550; heterocyclic compound binding;nucleotide binding;purine ribonucleoside triphosphate binding;transferase activity;purine nucleotide binding;carbohydrate derivative binding;adenyl nucleotide binding;molecular_function;nucleoside phosphate binding;ribonucleoside binding;ATP binding;anion binding;kinase activity;catalytic activity;transferase activity, transferring phosphorus-containing groups;phosphotransferase activity, carboxyl group as acceptor;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;ion binding;phosphoglycerate kinase activity;organic cyclic compound binding;binding;purine nucleoside binding;nucleoside binding;small molecule binding;purine ribonucleoside binding; 3;4;5;3;5;3;6;1;4;5;6;4;5;2;4;5;6;5;4;3;6;3;2;5;4;3;6; K00927 map00010;map00710;map01100;map01110;map01120;map01130;map01200;map01230; Glycolysis / Gluconeogenesis;Carbon fixation in photosynthetic organisms;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids; IPR015911;IPR015824;IPR001576; Phosphoglycerate kinase, conserved site;Phosphoglycerate kinase, N-terminal;Phosphoglycerate kinase; cytosol Hs20270259 848.0 G [G] Carbohydrate transport and metabolism; P07204 Thrombomodulin OS=Homo sapiens OX=9606 GN=THBD PE=1 SV=2 - [TRBM_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0007599;GO:0032101;GO:0048585;GO:0007596;GO:0048583;GO:0061041;GO:0061045;GO:0032102;GO:0050789;GO:0044699;GO:0051241;GO:0009611;GO:1900046;GO:1900047;GO:0065007;GO:0048519;GO:0065008;GO:1903034;GO:1903035;GO:0032501;GO:0050878;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:0050818;GO:0050819;GO:0009605;GO:0044707;GO:0050896;GO:0030193;GO:0080134;GO:0030195; hemostasis;regulation of response to external stimulus;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;regulation of wound healing;negative regulation of wound healing;negative regulation of response to external stimulus;regulation of biological process;single-organism process;negative regulation of multicellular organismal process;response to wounding;regulation of hemostasis;negative regulation of hemostasis;biological regulation;negative regulation of biological process;regulation of biological quality;regulation of response to wounding;negative regulation of response to wounding;multicellular organismal process;regulation of body fluid levels;wound healing;response to stress;coagulation;biological_process;regulation of multicellular organismal process;regulation of coagulation;negative regulation of coagulation;response to external stimulus;single-multicellular organism process;response to stimulus;regulation of blood coagulation;regulation of response to stress;negative regulation of blood coagulation; 5;4;3;5;3;6;5;4;2;2;3;4;4;4;2;2;3;5;4;2;4;5;3;4;1;3;4;4;3;3;2;5;4;5; GO:0016020;GO:0071944;GO:0005887;GO:0031226;GO:0016021;GO:0005886;GO:0044459;GO:0044464;GO:0005623;GO:0031224;GO:0005575;GO:0044425; membrane;cell periphery;integral component of plasma membrane;intrinsic component of plasma membrane;integral component of membrane;plasma membrane;plasma membrane part;cell part;cell;intrinsic component of membrane;cellular_component;membrane part; 2;3;4;4;4;3;3;2;2;3;1;2; GO:0004871;GO:0060089;GO:0003674;GO:0004872;GO:0043169;GO:0043167;GO:0005509;GO:0046872;GO:0004888;GO:0099600;GO:0038023;GO:0005488; signal transducer activity;molecular transducer activity;molecular_function;receptor activity;cation binding;ion binding;calcium ion binding;metal ion binding;transmembrane signaling receptor activity;transmembrane receptor activity;signaling receptor activity;binding; 2;2;1;3;4;3;6;5;4;4;3;2; K03907 map04610;map04933; Complement and coagulation cascades;AGE-RAGE signaling pathway in diabetic complications; IPR000152;IPR018097;IPR001304;IPR009030;IPR026823;IPR016316;IPR000742;IPR016186;IPR016187;IPR001881;IPR013032;IPR015149; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;C-type lectin-like;Growth factor receptor cysteine-rich domain;Complement Clr-like EGF domain;Thrombomodulin;EGF-like domain;C-type lectin-like/link domain;C-type lectin fold;EGF-like calcium-binding domain;EGF-like, conserved site;Thrombomodulin-like, EGF-like; plasma membrane Q4U2R8 Solute carrier family 22 member 6 OS=Homo sapiens OX=9606 GN=SLC22A6 PE=1 SV=1 - [S22A6_HUMAN] 0.762 0.953 1.607 0.724 1.068 0.655 0.799580273 0.007235502 0.677902622 0.002568628 1.686253935 0.009585923 0.61329588 0.262367136 GO:0006820;GO:0003014;GO:0071840;GO:0015849;GO:0015711;GO:0006835;GO:0010033;GO:0003008;GO:0044707;GO:0010243;GO:0022607;GO:0016043;GO:0065003;GO:0014070;GO:0006811;GO:0006810;GO:0008150;GO:0051234;GO:0043252;GO:0046903;GO:1901698;GO:0097254;GO:0070271;GO:0009719;GO:0032501;GO:0009987;GO:0001101;GO:0055085;GO:0051259;GO:0044699;GO:0031427;GO:0050896;GO:0043933;GO:0071822;GO:0051260;GO:0071702;GO:0006461;GO:0034220;GO:0044765;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0046942;GO:1901700;GO:0044085;GO:0098656;GO:0015742; anion transport;renal system process;cellular component organization or biogenesis;organic acid transport;organic anion transport;dicarboxylic acid transport;response to organic substance;system process;single-multicellular organism process;response to organonitrogen compound;cellular component assembly;cellular component organization;macromolecular complex assembly;response to organic cyclic compound;ion transport;transport;biological_process;establishment of localization;sodium-independent organic anion transport;secretion;response to nitrogen compound;renal tubular secretion;protein complex biogenesis;response to endogenous stimulus;multicellular organismal process;cellular process;response to acid chemical;transmembrane transport;protein oligomerization;single-organism process;response to methotrexate;response to stimulus;macromolecular complex subunit organization;protein complex subunit organization;protein homooligomerization;organic substance transport;protein complex assembly;ion transmembrane transport;single-organism transport;single-organism cellular process;response to chemical;localization;single-organism localization;carboxylic acid transport;response to oxygen-containing compound;cellular component biogenesis;anion transmembrane transport;alpha-ketoglutarate transport; 6;4;2;5;6;7;4;3;3;4;4;3;5;5;5;4;1;3;7;5;4;4;4;3;2;2;4;4;6;2;5;2;4;5;7;5;5;5;4;3;3;2;3;6;4;3;6;8; GO:0044853;GO:0031982;GO:0016020;GO:0098589;GO:0043234;GO:0043230;GO:0044425;GO:0098857;GO:0044421;GO:0098590;GO:0043227;GO:0043226;GO:0016021;GO:0005901;GO:0031226;GO:0031224;GO:0044459;GO:0016323;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0098805;GO:0005576;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0045121;GO:0005575; plasma membrane raft;vesicle;membrane;membrane region;protein complex;extracellular organelle;membrane part;membrane microdomain;extracellular region part;plasma membrane region;membrane-bounded organelle;organelle;integral component of membrane;caveola;intrinsic component of plasma membrane;intrinsic component of membrane;plasma membrane part;basolateral plasma membrane;cell part;cell;cell periphery;extracellular exosome;whole membrane;extracellular region;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;membrane raft;cellular_component; 4;4;2;3;3;3;2;4;2;4;3;2;4;5;4;3;3;4;2;2;3;4;3;2;4;3;3;2;5;1; GO:0008509;GO:0003674;GO:0005488;GO:0022804;GO:0043168;GO:0022891;GO:0022892;GO:0031404;GO:0015075;GO:0043167;GO:0015291;GO:0005215;GO:0005452;GO:0015103;GO:0008514;GO:0015347;GO:0022857; anion transmembrane transporter activity;molecular_function;binding;active transmembrane transporter activity;anion binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;chloride ion binding;ion transmembrane transporter activity;ion binding;secondary active transmembrane transporter activity;transporter activity;inorganic anion exchanger activity;inorganic anion transmembrane transporter activity;organic anion transmembrane transporter activity;sodium-independent organic anion transmembrane transporter activity;transmembrane transporter activity; 6;1;2;4;4;4;3;5;5;3;5;2;6;7;7;6;3; K08203 IPR020846;IPR005828;IPR004749; Major facilitator superfamily domain;Major facilitator, sugar transporter-like;Organic cation transport protein/SVOP; plasma membrane Hs20070188 1156.0 R [R] General function prediction only; Q9BWP8 Collectin-11 OS=Homo sapiens OX=9606 GN=COLEC11 PE=1 SV=1 - [COL11_HUMAN] 0.899 0.947 1.213 1.085 0.921 1.37 0.949313622 nan 1.178067318 nan 1.280887012 nan 1.487513572 nan GO:0048856;GO:0007275;GO:0044699;GO:0032502;GO:0032501;GO:0006810;GO:0044767;GO:0008150;GO:0006897;GO:0051234;GO:0051179;GO:0016192;GO:0044707;GO:0006898; anatomical structure development;multicellular organism development;single-organism process;developmental process;multicellular organismal process;transport;single-organism developmental process;biological_process;endocytosis;establishment of localization;localization;vesicle-mediated transport;single-multicellular organism process;receptor-mediated endocytosis; 3;4;2;2;2;4;3;1;6;3;2;5;3;7; GO:0005581;GO:0043234;GO:0032991;GO:0005575;GO:0005576; collagen trimer;protein complex;macromolecular complex;cellular_component;extracellular region; 4;3;2;1;2; GO:0030246;GO:0003674;GO:0005488;GO:0036094;GO:0005537;GO:0048029; carbohydrate binding;molecular_function;binding;small molecule binding;mannose binding;monosaccharide binding; 3;1;2;3;5;4; K10066 map04145; Phagosome; IPR001304;IPR033990;IPR018378;IPR008160;IPR016186;IPR016187; C-type lectin-like;Collectin, C-type lectin-like domain;C-type lectin, conserved site;Collagen triple helix repeat;C-type lectin-like/link domain;C-type lectin fold; extracellular Hs13128972 555.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; Q12816 Trophinin OS=Homo sapiens OX=9606 GN=TRO PE=1 SV=3 - [TROP_HUMAN] 0.946 0.808 1.497 0.952 0.817 1.197 1.170792079 nan 1.165238678 nan 1.852722772 nan 1.465116279 nan GO:0045926;GO:0030308;GO:0007275;GO:0051128;GO:0050789;GO:0071840;GO:0016049;GO:0040007;GO:0040008;GO:0016043;GO:0065007;GO:0044699;GO:0048519;GO:0051704;GO:0022610;GO:0032502;GO:0032501;GO:0098609;GO:0009987;GO:0050794;GO:0044767;GO:0022414;GO:0001558;GO:0044763;GO:0007155;GO:0007156;GO:0098742;GO:0000003;GO:0044703;GO:0044702;GO:0044707;GO:0044706;GO:0007565;GO:0007566;GO:0048856;GO:0008150;GO:0048523; negative regulation of growth;negative regulation of cell growth;multicellular organism development;regulation of cellular component organization;regulation of biological process;cellular component organization or biogenesis;cell growth;growth;regulation of growth;cellular component organization;biological regulation;single-organism process;negative regulation of biological process;multi-organism process;biological adhesion;developmental process;multicellular organismal process;cell-cell adhesion;cellular process;regulation of cellular process;single-organism developmental process;reproductive process;regulation of cell growth;single-organism cellular process;cell adhesion;homophilic cell adhesion via plasma membrane adhesion molecules;cell-cell adhesion via plasma-membrane adhesion molecules;reproduction;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;multi-multicellular organism process;female pregnancy;embryo implantation;anatomical structure development;biological_process;negative regulation of cellular process; 3;4;4;4;2;2;3;2;3;3;2;2;2;2;2;2;2;4;2;3;3;2;4;3;3;6;5;2;3;3;3;3;4;4;3;1;3; GO:0016021;GO:0031224;GO:0043229;GO:0071944;GO:0043227;GO:0005737;GO:0031226;GO:0016020;GO:0043226;GO:0044425;GO:0044459;GO:0005887;GO:0005886;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0005634; integral component of membrane;intrinsic component of membrane;intracellular organelle;cell periphery;membrane-bounded organelle;cytoplasm;intrinsic component of plasma membrane;membrane;organelle;membrane part;plasma membrane part;integral component of plasma membrane;plasma membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part;nucleus; 4;3;3;3;3;4;4;2;2;2;3;4;3;4;2;2;3;1;3;5; IPR002190; MAGE homology domain; nucleus Hs7705566 2706.0 S [S] Function unknown; Q99728 BRCA1-associated RING domain protein 1 OS=Homo sapiens OX=9606 GN=BARD1 PE=1 SV=2 - [BARD1_HUMAN] 0.115 0.135 3.67 0.799 0.152 0.302 0.851851852 0.571474071 5.256578947 0.004984982 27.18518519 0.000695919 1.986842105 0.067691163 GO:0033157;GO:0051169;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0060249;GO:0050684;GO:0032386;GO:0050686;GO:0051168;GO:0044707;GO:1901360;GO:0051716;GO:0006303;GO:0006302;GO:0070727;GO:0070647;GO:0010467;GO:0032446;GO:0051049;GO:0048518;GO:0048519;GO:0042176;GO:0042325;GO:0032387;GO:0051051;GO:0006281;GO:0060255;GO:0060548;GO:0045184;GO:0030163;GO:0046483;GO:0048871;GO:0019538;GO:0010468;GO:0016567;GO:0033554;GO:0009896;GO:0051224;GO:0009894;GO:0051252;GO:0009892;GO:0009893;GO:1903650;GO:0006807;GO:0009057;GO:0042981;GO:0050789;GO:0044267;GO:1901575;GO:0006886;GO:0065007;GO:0007049;GO:0085020;GO:0065008;GO:0070201;GO:0034613;GO:1903649;GO:0006139;GO:0006810;GO:0044710;GO:0050794;GO:0007050;GO:0012501;GO:0006950;GO:0036211;GO:0008150;GO:0031123;GO:0008152;GO:0045786;GO:0051234;GO:0010604;GO:0016070;GO:0016071;GO:0046907;GO:0050896;GO:0043412;GO:0045732;GO:0046825;GO:0046822;GO:0046823;GO:1903311;GO:1903312;GO:0016310;GO:1903827;GO:0034641;GO:1904950;GO:0000209;GO:0044699;GO:0032880;GO:0000726;GO:0000725;GO:0000724;GO:0009056;GO:0051246;GO:0051247;GO:0006611;GO:0032501;GO:0009987;GO:0006725;GO:0006974;GO:0010605;GO:0001894;GO:0032879;GO:0016482;GO:0042592;GO:0033036;GO:0031440;GO:0051253;GO:0031441;GO:0010629;GO:0043170;GO:1903828;GO:0060341;GO:0031324;GO:0031323;GO:0090304;GO:0022402;GO:0010942;GO:0008219;GO:0010941;GO:0046826;GO:0051223;GO:0043065;GO:0071704;GO:0043067;GO:0043066;GO:0071702;GO:0043069;GO:0043068;GO:0045934;GO:0019219;GO:0031124;GO:0006915;GO:0090317;GO:0006913;GO:0006464;GO:0051174;GO:0015031;GO:0044765;GO:0044763;GO:0051171;GO:0051172;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006310;GO:0044238;GO:0044260;GO:0045003;GO:0051726;GO:0044237;GO:0006796;GO:0006396;GO:0006793;GO:0006259;GO:1902582;GO:0006397;GO:0048523;GO:0048522; regulation of intracellular protein transport;nuclear transport;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;anatomical structure homeostasis;regulation of mRNA processing;regulation of intracellular transport;negative regulation of mRNA processing;nuclear export;single-multicellular organism process;organic cyclic compound metabolic process;cellular response to stimulus;double-strand break repair via nonhomologous end joining;double-strand break repair;cellular macromolecule localization;protein modification by small protein conjugation or removal;gene expression;protein modification by small protein conjugation;regulation of transport;positive regulation of biological process;negative regulation of biological process;regulation of protein catabolic process;regulation of phosphorylation;negative regulation of intracellular transport;negative regulation of transport;DNA repair;regulation of macromolecule metabolic process;negative regulation of cell death;establishment of protein localization;protein catabolic process;heterocycle metabolic process;multicellular organismal homeostasis;protein metabolic process;regulation of gene expression;protein ubiquitination;cellular response to stress;positive regulation of catabolic process;negative regulation of protein transport;regulation of catabolic process;regulation of RNA metabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of cytoplasmic transport;nitrogen compound metabolic process;macromolecule catabolic process;regulation of apoptotic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;intracellular protein transport;biological regulation;cell cycle;protein K6-linked ubiquitination;regulation of biological quality;regulation of establishment of protein localization;cellular protein localization;regulation of cytoplasmic transport;nucleobase-containing compound metabolic process;transport;single-organism metabolic process;regulation of cellular process;cell cycle arrest;programmed cell death;response to stress;protein modification process;biological_process;RNA 3'-end processing;metabolic process;negative regulation of cell cycle;establishment of localization;positive regulation of macromolecule metabolic process;RNA metabolic process;mRNA metabolic process;intracellular transport;response to stimulus;macromolecule modification;positive regulation of protein catabolic process;regulation of protein export from nucleus;regulation of nucleocytoplasmic transport;negative regulation of nucleocytoplasmic transport;regulation of mRNA metabolic process;negative regulation of mRNA metabolic process;phosphorylation;regulation of cellular protein localization;cellular nitrogen compound metabolic process;negative regulation of establishment of protein localization;protein polyubiquitination;single-organism process;regulation of protein localization;non-recombinational repair;recombinational repair;double-strand break repair via homologous recombination;catabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;protein export from nucleus;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;negative regulation of macromolecule metabolic process;tissue homeostasis;regulation of localization;cytosolic transport;homeostatic process;macromolecule localization;regulation of mRNA 3'-end processing;negative regulation of RNA metabolic process;negative regulation of mRNA 3'-end processing;negative regulation of gene expression;macromolecule metabolic process;negative regulation of cellular protein localization;regulation of cellular localization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;positive regulation of cell death;cell death;regulation of cell death;negative regulation of protein export from nucleus;regulation of protein transport;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;organic substance transport;negative regulation of programmed cell death;positive regulation of programmed cell death;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;mRNA 3'-end processing;apoptotic process;negative regulation of intracellular protein transport;nucleocytoplasmic transport;cellular protein modification process;regulation of phosphorus metabolic process;protein transport;single-organism transport;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;localization;single-organism localization;cellular localization;DNA recombination;primary metabolic process;cellular macromolecule metabolic process;double-strand break repair via synthesis-dependent strand annealing;regulation of cell cycle;cellular metabolic process;phosphate-containing compound metabolic process;RNA processing;phosphorus metabolic process;DNA metabolic process;single-organism intracellular transport;mRNA processing;negative regulation of cellular process;positive regulation of cellular process; 6;6;4;6;4;3;5;6;5;6;8;3;4;3;6;5;4;7;5;8;4;2;2;5;7;4;3;4;4;4;4;5;4;4;4;5;9;4;4;4;4;5;3;3;5;3;5;6;2;5;4;6;2;4;11;3;5;5;6;4;4;3;3;5;5;3;5;1;7;2;4;3;4;5;6;5;2;5;5;7;7;6;6;6;6;5;4;3;10;2;4;5;5;6;3;5;5;6;2;2;4;5;4;5;3;6;4;3;7;5;7;5;4;3;4;4;4;5;4;4;4;4;5;5;6;3;5;6;5;5;5;5;5;8;6;4;7;6;5;5;4;3;4;4;4;2;3;3;6;3;4;7;4;3;5;6;4;5;5;7;3;3; GO:0031974;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0000151;GO:0000152;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0070531;GO:0044464;GO:0005623;GO:0031436;GO:0043227;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;ubiquitin ligase complex;nuclear ubiquitin ligase complex;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;BRCA1-A complex;cell part;cell;BRCA1-BARD1 complex;membrane-bounded organelle;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;5;3;4;3;4;5;4;3;2;3;3;5;3;4;5;4;2;2;6;3;2;2;1;4; GO:0008270;GO:0016740;GO:0046872;GO:0019900;GO:0003674;GO:0005488;GO:0003676;GO:0046914;GO:1901363;GO:0019787;GO:0004842;GO:0003824;GO:0097159;GO:0046983;GO:0046982;GO:0019899;GO:0043169;GO:0043167;GO:0042802;GO:0042803;GO:0003723;GO:0005515;GO:0016874; zinc ion binding;transferase activity;metal ion binding;kinase binding;molecular_function;binding;nucleic acid binding;transition metal ion binding;heterocyclic compound binding;ubiquitin-like protein transferase activity;ubiquitin-protein transferase activity;catalytic activity;organic cyclic compound binding;protein dimerization activity;protein heterodimerization activity;enzyme binding;cation binding;ion binding;identical protein binding;protein homodimerization activity;RNA binding;protein binding;ligase activity; 7;3;5;5;1;2;4;6;3;4;5;2;3;4;5;4;4;3;4;5;5;3;3; K10683 IPR033097;IPR002110;IPR001841;IPR001357;IPR020683;IPR013083;IPR017907; BRCA1-associated RING domain protein 1;Ankyrin repeat;Zinc finger, RING-type;BRCT domain;Ankyrin repeat-containing domain;Zinc finger, RING/FYVE/PHD-type;Zinc finger, RING-type, conserved site; nucleus 190571059 97.1 T [T] Signal transduction mechanisms; COG0666 Ankyrin repeat Q8IYB1 Protein MB21D2 OS=Homo sapiens OX=9606 GN=MB21D2 PE=1 SV=3 - [M21D2_HUMAN] 0.809 0.907 1.529 0.892 0.962 0.912 0.891951488 nan 0.927234927 nan 1.685777288 nan 0.948024948 nan GO:0032403;GO:0003674;GO:0044877;GO:0005488;GO:0005515; protein complex binding;molecular_function;macromolecular complex binding;binding;protein binding; 4;1;3;2;3; IPR024810; Mab-21 domain; cytosol Hs22043920 1026.0 T [T] Signal transduction mechanisms; P06681 Complement C2 OS=Homo sapiens OX=9606 GN=C2 PE=1 SV=2 - [CO2_HUMAN] 0.976 0.927 1.082 1.047 0.905 1.192 1.052858684 0.29185887 1.156906077 2.07E-08 1.167206041 1.26E-06 1.317127072 1.59E-09 GO:0006909;GO:0080090;GO:0019222;GO:0051049;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:2000425;GO:0019724;GO:0051050;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0051128;GO:0016192;GO:0009605;GO:0019538;GO:0031667;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0016043;GO:0002684;GO:0002682;GO:0071840;GO:0007584;GO:0051130;GO:0006810;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0006956;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0002697;GO:0008150;GO:1903317;GO:0008152;GO:0032101;GO:0009611;GO:0043277;GO:0044699;GO:0050766;GO:0050764;GO:0051234;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0060627;GO:2000427;GO:0016485;GO:0032879;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0009991;GO:0072376;GO:0002443;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044765;GO:0042221;GO:0030100;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0045807;GO:0048522; phagocytosis;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;regulation of apoptotic cell clearance;B cell mediated immunity;positive regulation of transport;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;regulation of cellular component organization;vesicle-mediated transport;response to external stimulus;protein metabolic process;response to nutrient levels;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;cellular component organization;positive regulation of immune system process;regulation of immune system process;cellular component organization or biogenesis;response to nutrient;positive regulation of cellular component organization;transport;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;complement activation;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;endocytosis;protein maturation;response to stimulus;regulation of immune effector process;biological_process;regulation of protein maturation;metabolic process;regulation of response to external stimulus;response to wounding;apoptotic cell clearance;single-organism process;positive regulation of phagocytosis;regulation of phagocytosis;establishment of localization;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;regulation of vesicle-mediated transport;positive regulation of apoptotic cell clearance;protein processing;regulation of localization;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;response to extracellular stimulus;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;single-organism transport;response to chemical;regulation of endocytosis;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of endocytosis;positive regulation of cellular process; 5;4;3;4;3;3;5;5;3;5;2;2;7;6;3;4;4;6;6;4;5;3;4;5;2;5;5;2;3;3;3;2;4;4;4;3;4;3;7;4;5;3;6;5;4;7;6;5;2;4;1;6;2;4;4;6;2;5;6;3;5;5;5;2;4;6;6;3;4;5;4;4;4;4;3;4;3;5;5;4;5;4;3;5;2;3;3;4;3;3;4;3; GO:0031982;GO:0043230;GO:0044421;GO:0043227;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;extracellular organelle;extracellular region part;membrane-bounded organelle;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;3;2;3;4;2;3;3;1;2; GO:0004252;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0046872;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0004175;GO:0017171;GO:0070011; serine-type endopeptidase activity;molecular_function;binding;hydrolase activity;catalytic activity;metal ion binding;peptidase activity;serine-type peptidase activity;cation binding;ion binding;endopeptidase activity;serine hydrolase activity;peptidase activity, acting on L-amino acid peptides; 6;1;2;3;2;5;4;5;4;3;6;4;5; K01332 map04610;map05133;map05150;map05322; Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus; IPR001254;IPR000436;IPR009003;IPR001314;IPR002035;IPR033116;IPR011360;IPR018114; Serine proteases, trypsin domain;Sushi/SCR/CCP domain;Peptidase S1, PA clan;Peptidase S1A, chymotrypsin family;von Willebrand factor, type A;Serine proteases, trypsin family, serine active site;Complement B/C2;Serine proteases, trypsin family, histidine active site; extracellular Hs14550407 1570.0 E [E] Amino acid transport and metabolism; Q70CQ2 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2 - [UBP34_HUMAN] 1.031 0.985 0.943 1.109 1.041 1.396 1.046700508 nan 1.065321806 nan 0.957360406 nan 1.341018252 nan GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0030111;GO:0007165;GO:0007166;GO:1901362;GO:0071840;GO:0044710;GO:0009966;GO:0009967;GO:0070647;GO:0070646;GO:0048518;GO:0060255;GO:0030163;GO:2001141;GO:0046483;GO:0044700;GO:0019538;GO:0016055;GO:0019438;GO:0060828;GO:0016569;GO:0090263;GO:0071108;GO:0006807;GO:0097659;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0016043;GO:0065007;GO:0016570;GO:0016579;GO:0016578;GO:0018130;GO:0006139;GO:0009889;GO:0051716;GO:0050794;GO:0060070;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0051603;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0032774;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0009057;GO:0006508;GO:0009987;GO:0006725;GO:1903506;GO:0044257;GO:0051252;GO:0030177;GO:0043170;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0043632;GO:0006325;GO:1901360;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0006511;GO:0010468;GO:0006351;GO:1901576;GO:0019219;GO:0019941;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007154;GO:0009056;GO:0016568;GO:0044248;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:1902589;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism metabolic process;regulation of signal transduction;positive regulation of signal transduction;protein modification by small protein conjugation or removal;protein modification by small protein removal;positive regulation of biological process;regulation of macromolecule metabolic process;protein catabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;protein metabolic process;Wnt signaling pathway;aromatic compound biosynthetic process;regulation of canonical Wnt signaling pathway;covalent chromatin modification;positive regulation of canonical Wnt signaling pathway;protein K48-linked deubiquitination;nitrogen compound metabolic process;nucleic acid-templated transcription;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;histone modification;protein deubiquitination;histone deubiquitination;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;canonical Wnt signaling pathway;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;proteolysis involved in cellular protein catabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;RNA biosynthetic process;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;macromolecule catabolic process;proteolysis;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular protein catabolic process;regulation of RNA metabolic process;positive regulation of Wnt signaling pathway;macromolecule metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;modification-dependent macromolecule catabolic process;chromatin organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;ubiquitin-dependent protein catabolic process;regulation of gene expression;transcription, DNA-templated;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;modification-dependent protein catabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;catabolic process;chromatin modification;cellular catabolic process;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;single-organism organelle organization;positive regulation of cellular process; 4;3;3;3;5;4;5;5;2;3;4;4;7;6;2;4;5;6;4;3;4;6;5;6;7;6;8;3;7;5;4;5;4;3;2;4;7;5;5;4;4;3;3;7;5;5;1;2;5;5;6;5;2;6;5;6;3;4;4;2;5;3;4;4;2;5;5;2;4;7;6;5;5;4;4;5;4;5;6;5;4;6;2;3;5;8;5;6;4;5;7;6;3;5;3;4;4;3;6;4;4;3;5;3;4;3; GO:0031974;GO:0031981;GO:1902493;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0031248;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0044444;GO:0044422;GO:0005737;GO:0000124;GO:0000123;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0070461;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;acetyltransferase complex;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;protein acetyltransferase complex;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;organelle part;cytoplasm;SAGA complex;histone acetyltransferase complex;nucleus;nucleoplasm part;cell part;cell;SAGA-type complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;6;4;5;3;4;3;5;4;3;4;3;3;3;2;5;3;4;2;4;7;5;5;5;2;2;6;2;1;4; GO:0003674;GO:0004843;GO:0016787;GO:0036459;GO:0003824;GO:0101005;GO:0008234;GO:0019783;GO:0004197;GO:0008233;GO:0004175;GO:0070011; molecular_function;thiol-dependent ubiquitin-specific protease activity;hydrolase activity;thiol-dependent ubiquitinyl hydrolase activity;catalytic activity;ubiquitinyl hydrolase activity;cysteine-type peptidase activity;ubiquitin-like protein-specific protease activity;cysteine-type endopeptidase activity;peptidase activity;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 1;6;3;5;2;4;6;7;7;4;6;5; K11853 IPR018200;IPR016024;IPR011989;IPR001394;IPR028889; Ubiquitin specific protease, conserved site;Armadillo-type fold;Armadillo-like helical;Peptidase C19, ubiquitin carboxyl-terminal hydrolase;Ubiquitin specific protease domain; plasma membrane Q9P241 Probable phospholipid-transporting ATPase VD OS=Homo sapiens OX=9606 GN=ATP10D PE=2 SV=3 - [AT10D_HUMAN] 1.03 1.53 0.774 0.909 1.018 0.927 0.673202614 nan 0.892927308 nan 0.505882353 nan 0.910609037 nan GO:0061024;GO:0006820;GO:0071840;GO:0097035;GO:0033036;GO:0015711;GO:0034204;GO:0010876;GO:0015914;GO:0016043;GO:0065007;GO:0065008;GO:0006812;GO:0006811;GO:0006810;GO:0044802;GO:0051234;GO:0008150;GO:0045332;GO:0006869;GO:0044699;GO:0009987;GO:0055085;GO:0071702;GO:0034220;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0015748; membrane organization;anion transport;cellular component organization or biogenesis;regulation of membrane lipid distribution;macromolecule localization;organic anion transport;lipid translocation;lipid localization;phospholipid transport;cellular component organization;biological regulation;regulation of biological quality;cation transport;ion transport;transport;single-organism membrane organization;establishment of localization;biological_process;phospholipid translocation;lipid transport;single-organism process;cellular process;transmembrane transport;organic substance transport;ion transmembrane transport;single-organism transport;single-organism cellular process;localization;single-organism localization;organophosphate ester transport; 4;6;2;4;3;6;5;4;6;3;2;3;6;5;4;4;3;1;6;5;2;2;4;5;5;4;3;2;3;5; GO:0005783;GO:0031974;GO:0005789;GO:0031981;GO:0016021;GO:0016020;GO:0098588;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044432;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0042175;GO:0031090;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005886;GO:0005737;GO:0005575;GO:0070013; endoplasmic reticulum;membrane-enclosed lumen;endoplasmic reticulum membrane;nuclear lumen;integral component of membrane;membrane;bounding membrane of organelle;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;endoplasmic reticulum part;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;organelle membrane;nucleus;cell part;cell;intracellular;cell periphery;plasma membrane;cytoplasm;cellular_component;intracellular organelle lumen; 4;2;3;5;4;2;4;4;3;4;3;2;2;3;3;2;5;4;3;3;3;4;3;3;5;2;2;3;3;3;4;1;4; GO:0004012;GO:1901363;GO:0005548;GO:0000166;GO:0005319;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0022892;GO:0097159;GO:0043492;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0043169;GO:0000287;GO:0043167;GO:0005215;GO:0046872;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0036094; phospholipid-translocating ATPase activity;heterocyclic compound binding;phospholipid transporter activity;nucleotide binding;lipid transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;substrate-specific transporter activity;organic cyclic compound binding;ATPase activity, coupled to movement of substances;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;cation binding;magnesium ion binding;ion binding;transporter activity;metal ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding; 6;3;5;4;4;5;3;4;1;2;8;4;9;5;5;6;3;2;3;3;10;6;6;5;6;4;5;4;4;6;3;2;5;6;5;4;7;3; K01530 IPR018303;IPR023298;IPR023299;IPR023214;IPR008250;IPR032631;IPR032630;IPR006539;IPR030360;IPR001757; P-type ATPase, phosphorylation site;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;HAD-like domain;P-type ATPase, A domain;P-type ATPase, N-terminal;P-type ATPase, C-terminal;P-type ATPase, subfamily IV;Probable phospholipid-transporting ATPase VD;P-type ATPase; plasma membrane Hs20533656 1395.0 R [R] General function prediction only; Q5JST6 EF-hand domain-containing family member C2 OS=Homo sapiens OX=9606 GN=EFHC2 PE=1 SV=2 - [EFHC2_HUMAN] 0.936 0.969 1.277 0.977 0.987 1.033 0.965944272 0.717721679 0.989868288 0.976208123 1.317853457 0.227937488 1.046605876 0.471527467 GO:0043169;GO:0043167;GO:0003674;GO:0005488;GO:0046872;GO:0005509; cation binding;ion binding;molecular_function;binding;metal ion binding;calcium ion binding; 4;3;1;2;5;6; IPR006602;IPR002048;IPR011992;IPR010554; Uncharacterised domain DM10;EF-hand domain;EF-hand domain pair;Domain of unknown function DUF1126; cytosol Hs13376776 505.0 S [S] Function unknown; Q5TD97 Four and a half LIM domains protein 5 OS=Homo sapiens OX=9606 GN=FHL5 PE=1 SV=1 - [FHL5_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010604;GO:0048518;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0006139;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:1902680;GO:0010628;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:2000112;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;2;4;6;4;5;3;4;3;4;2;7;4;4;2;7;5;4;4;3;1;2;5;5;5;6;5;5;6;6;4;4;5;7;2;4;7;6;5;5;6;5;7;5;5;4;4;5;6;3;5;7;5;5;5;3;5;4;4;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:0008270;GO:0003713;GO:0003712;GO:0046872;GO:0000988;GO:0003674;GO:0005488;GO:0000989;GO:0043169;GO:0043167;GO:0046914; zinc ion binding;transcription coactivator activity;transcription cofactor activity;metal ion binding;transcription factor activity, protein binding;molecular_function;binding;transcription factor activity, transcription factor binding;cation binding;ion binding;transition metal ion binding; 7;5;4;5;2;1;2;3;4;3;6; IPR001781; Zinc finger, LIM-type; nucleus Hs19924173 580.0 TZR [T] Signal transduction mechanisms;[Z] Cytoskeleton;[R] General function prediction only; O94854 Uncharacterized protein KIAA0754 OS=Homo sapiens OX=9606 GN=KIAA0754 PE=2 SV=4 - [K0754_HUMAN] 0.765 0.876 1.658 0.953 0.884 0.737 0.873287671 nan 1.078054299 nan 1.892694064 nan 0.833710407 nan GO:0016020;GO:0044464;GO:0005623;GO:0005575;GO:0071944;GO:0005886; membrane;cell part;cell;cellular_component;cell periphery;plasma membrane; 2;2;2;1;3;3; nucleus 296111705 70.9 S [S] Function unknown; COG5373 Uncharacterized membrane protein P06727 Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=3 - [APOA4_HUMAN] 1.248 0.955 0.947 1.043 0.91 0.943 1.306806283 9.96E-70 1.146153846 2.12E-31 0.991623037 0.005189059 1.036263736 7.61E-06 GO:0051049;GO:0044281;GO:0044283;GO:0071451;GO:0051716;GO:0016101;GO:0046503;GO:0031102;GO:0030299;GO:0046486;GO:0006576;GO:0019538;GO:0009896;GO:0009894;GO:0009892;GO:0009893;GO:0009891;GO:0000305;GO:0000303;GO:0000302;GO:0031175;GO:0050789;GO:0051345;GO:0097006;GO:0002385;GO:0098602;GO:0006629;GO:0009308;GO:0098609;GO:0042439;GO:0006695;GO:0006694;GO:0051246;GO:0009416;GO:0014070;GO:0046889;GO:0044255;GO:0030258;GO:0006979;GO:0033194;GO:0046470;GO:0045923;GO:0030030;GO:0042592;GO:0007275;GO:0055090;GO:0009636;GO:0055092;GO:0080184;GO:0009605;GO:0019217;GO:0019216;GO:0019218;GO:0045087;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0048856;GO:0050994;GO:0050996;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0034441;GO:0034443;GO:0034442;GO:0034445;GO:0034444;GO:0007165;GO:0044712;GO:0044710;GO:0044711;GO:0098869;GO:0044093;GO:0033036;GO:0034367;GO:0034368;GO:0034369;GO:1902653;GO:1902652;GO:0030301;GO:0010033;GO:0044248;GO:0051006;GO:0015918;GO:0015850;GO:0015914;GO:0006807;GO:0006801;GO:0044267;GO:0097164;GO:0050790;GO:0009889;GO:0050794;GO:0051239;GO:0051234;GO:0051336;GO:0032368;GO:0046394;GO:0050896;GO:0050892;GO:0006633;GO:0060193;GO:0006631;GO:0060191;GO:0009314;GO:0006639;GO:0006638;GO:0070887;GO:0044699;GO:0051248;GO:0044057;GO:0044058;GO:0031099;GO:0010565;GO:0016126;GO:0016125;GO:0042161;GO:0042160;GO:0072593;GO:0048731;GO:0016337;GO:0043933;GO:0046890;GO:0001523;GO:0006066;GO:1901360;GO:0072330;GO:0030182;GO:0042221;GO:0022008;GO:0008610;GO:0009628;GO:0044237;GO:0044236;GO:0006775;GO:0019222;GO:0048468;GO:1901362;GO:0071840;GO:0048869;GO:0048518;GO:0048519;GO:0015711;GO:0007603;GO:0007602;GO:1990748;GO:0043436;GO:0055114;GO:0003008;GO:0044700;GO:1901564;GO:0044707;GO:0016053;GO:0002376;GO:0033554;GO:0019637;GO:0098856;GO:0033700;GO:0034377;GO:0034375;GO:0022607;GO:0022600;GO:0034372;GO:0034371;GO:0034370;GO:0034378;GO:0042157;GO:0098754;GO:0043170;GO:0045723;GO:0006811;GO:0006810;GO:0006952;GO:0006950;GO:0006955;GO:0042304;GO:0051606;GO:0061365;GO:1901617;GO:1901615;GO:0090208;GO:0090207;GO:0030154;GO:0032374;GO:0032371;GO:0031326;GO:0032502;GO:0006644;GO:0032501;GO:0006641;GO:0006721;GO:0006720;GO:0009987;GO:0032879;GO:1904478;GO:0006766;GO:0071704;GO:0034433;GO:0034434;GO:0034435;GO:0071702;GO:0007586;GO:0034614;GO:0009058;GO:0034599;GO:0009056;GO:0051179;GO:1902578;GO:0042180;GO:0080090;GO:0006820;GO:0010035;GO:0010605;GO:0006982;GO:0045834;GO:0010896;GO:0010898;GO:0060255;GO:0032787;GO:0010872;GO:0010873;GO:0010876;GO:0048878;GO:0019430;GO:0019433;GO:0042744;GO:0042743;GO:0070328;GO:1901576;GO:1901575;GO:0016043;GO:0016042;GO:0065003;GO:0071450;GO:0065007;GO:0065005;GO:0065009;GO:0065008;GO:1904729;GO:0008150;GO:0008152;GO:0042632;GO:0035634;GO:0006869;GO:0030300;GO:0043691;GO:0051004;GO:0044249;GO:0034641;GO:0023052;GO:0044240;GO:0044241;GO:0044242;GO:0044243;GO:0043085;GO:0046464;GO:0022610;GO:0046461;GO:0044238;GO:0046165;GO:0055088;GO:0044106;GO:0008202;GO:0008203;GO:0002227;GO:0006082;GO:0045940;GO:0033344;GO:0006650;GO:0031329;GO:0031328;GO:0034380;GO:0031325;GO:0031324;GO:0031323;GO:0019752;GO:0050748;GO:0050746;GO:0071825;GO:0071827;GO:0044085;GO:0031331;GO:0048666;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0007159;GO:0007155;GO:0007154;GO:0048699;GO:0044260;GO:0007399;GO:0002251;GO:0015748; regulation of transport;small molecule metabolic process;small molecule biosynthetic process;cellular response to superoxide;cellular response to stimulus;diterpenoid metabolic process;glycerolipid catabolic process;neuron projection regeneration;intestinal cholesterol absorption;glycerolipid metabolic process;cellular biogenic amine metabolic process;protein metabolic process;positive regulation of catabolic process;regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;response to oxygen radical;response to superoxide;response to reactive oxygen species;neuron projection development;regulation of biological process;positive regulation of hydrolase activity;regulation of plasma lipoprotein particle levels;mucosal immune response;single organism cell adhesion;lipid metabolic process;amine metabolic process;cell-cell adhesion;ethanolamine-containing compound metabolic process;cholesterol biosynthetic process;steroid biosynthetic process;regulation of protein metabolic process;response to light stimulus;response to organic cyclic compound;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;lipid modification;response to oxidative stress;response to hydroperoxide;phosphatidylcholine metabolic process;positive regulation of fatty acid metabolic process;cell projection organization;homeostatic process;multicellular organism development;acylglycerol homeostasis;response to toxic substance;sterol homeostasis;response to phenylpropanoid;response to external stimulus;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of steroid metabolic process;innate immune response;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;anatomical structure development;regulation of lipid catabolic process;positive regulation of lipid catabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;plasma lipoprotein particle oxidation;negative regulation of lipoprotein oxidation;regulation of lipoprotein oxidation;negative regulation of plasma lipoprotein particle oxidation;regulation of plasma lipoprotein particle oxidation;signal transduction;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular oxidant detoxification;positive regulation of molecular function;macromolecule localization;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;secondary alcohol biosynthetic process;secondary alcohol metabolic process;cholesterol transport;response to organic substance;cellular catabolic process;positive regulation of lipoprotein lipase activity;sterol transport;organic hydroxy compound transport;phospholipid transport;nitrogen compound metabolic process;superoxide metabolic process;cellular protein metabolic process;ammonium ion metabolic process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;regulation of lipid transport;carboxylic acid biosynthetic process;response to stimulus;intestinal absorption;fatty acid biosynthetic process;positive regulation of lipase activity;fatty acid metabolic process;regulation of lipase activity;response to radiation;acylglycerol metabolic process;neutral lipid metabolic process;cellular response to chemical stimulus;single-organism process;negative regulation of protein metabolic process;regulation of system process;regulation of digestive system process;regeneration;regulation of cellular ketone metabolic process;sterol biosynthetic process;sterol metabolic process;lipoprotein oxidation;lipoprotein modification;reactive oxygen species metabolic process;system development;single organismal cell-cell adhesion;macromolecular complex subunit organization;regulation of lipid biosynthetic process;retinoid metabolic process;alcohol metabolic process;organic cyclic compound metabolic process;monocarboxylic acid biosynthetic process;neuron differentiation;response to chemical;neurogenesis;lipid biosynthetic process;response to abiotic stimulus;cellular metabolic process;multicellular organism metabolic process;fat-soluble vitamin metabolic process;regulation of metabolic process;cell development;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular developmental process;positive regulation of biological process;negative regulation of biological process;organic anion transport;phototransduction, visible light;phototransduction;cellular detoxification;oxoacid metabolic process;oxidation-reduction process;system process;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;organic acid biosynthetic process;immune system process;cellular response to stress;organophosphate metabolic process;intestinal lipid absorption;phospholipid efflux;plasma lipoprotein particle assembly;high-density lipoprotein particle remodeling;cellular component assembly;digestive system process;very-low-density lipoprotein particle remodeling;chylomicron remodeling;triglyceride-rich lipoprotein particle remodeling;chylomicron assembly;lipoprotein metabolic process;detoxification;macromolecule metabolic process;positive regulation of fatty acid biosynthetic process;ion transport;transport;defense response;response to stress;immune response;regulation of fatty acid biosynthetic process;detection of stimulus;positive regulation of triglyceride lipase activity;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;positive regulation of triglyceride metabolic process;regulation of triglyceride metabolic process;cell differentiation;regulation of cholesterol transport;regulation of sterol transport;regulation of cellular biosynthetic process;developmental process;phospholipid metabolic process;multicellular organismal process;triglyceride metabolic process;terpenoid metabolic process;isoprenoid metabolic process;cellular process;regulation of localization;regulation of intestinal absorption;vitamin metabolic process;organic substance metabolic process;steroid esterification;sterol esterification;cholesterol esterification;organic substance transport;digestion;cellular response to reactive oxygen species;biosynthetic process;cellular response to oxidative stress;catabolic process;localization;single-organism localization;cellular ketone metabolic process;regulation of primary metabolic process;anion transport;response to inorganic substance;negative regulation of macromolecule metabolic process;response to lipid hydroperoxide;positive regulation of lipid metabolic process;regulation of triglyceride catabolic process;positive regulation of triglyceride catabolic process;regulation of macromolecule metabolic process;monocarboxylic acid metabolic process;regulation of cholesterol esterification;positive regulation of cholesterol esterification;lipid localization;chemical homeostasis;removal of superoxide radicals;triglyceride catabolic process;hydrogen peroxide catabolic process;hydrogen peroxide metabolic process;triglyceride homeostasis;organic substance biosynthetic process;organic substance catabolic process;cellular component organization;lipid catabolic process;macromolecular complex assembly;cellular response to oxygen radical;biological regulation;protein-lipid complex assembly;regulation of molecular function;regulation of biological quality;regulation of intestinal lipid absorption;biological_process;metabolic process;cholesterol homeostasis;response to stilbenoid;lipid transport;regulation of intestinal cholesterol absorption;reverse cholesterol transport;regulation of lipoprotein lipase activity;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;multicellular organism lipid catabolic process;lipid digestion;cellular lipid catabolic process;multicellular organism catabolic process;positive regulation of catalytic activity;acylglycerol catabolic process;biological adhesion;neutral lipid catabolic process;primary metabolic process;alcohol biosynthetic process;lipid homeostasis;cellular amine metabolic process;steroid metabolic process;cholesterol metabolic process;innate immune response in mucosa;organic acid metabolic process;positive regulation of steroid metabolic process;cholesterol efflux;glycerophospholipid metabolic process;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;high-density lipoprotein particle assembly;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;negative regulation of lipoprotein metabolic process;regulation of lipoprotein metabolic process;protein-lipid complex subunit organization;plasma lipoprotein particle organization;cellular component biogenesis;positive regulation of cellular catabolic process;neuron development;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;leukocyte cell-cell adhesion;cell adhesion;cell communication;generation of neurons;cellular macromolecule metabolic process;nervous system development;organ or tissue specific immune response;organophosphate ester transport; 4;4;5;7;3;7;6;5;6;5;6;4;4;4;3;3;4;5;6;5;5;2;6;3;5;3;4;5;4;4;8;6;5;5;5;5;4;5;4;5;5;5;4;4;4;7;4;7;6;3;6;5;6;4;3;4;3;4;5;3;5;5;5;4;3;3;6;6;6;7;7;4;4;3;4;4;4;3;5;6;4;7;6;7;4;4;8;6;5;6;3;5;5;4;4;4;3;3;3;5;5;6;2;4;6;7;5;6;4;6;5;4;2;5;4;5;4;5;7;6;5;6;4;4;4;4;5;8;5;4;7;6;3;6;5;3;3;4;6;3;4;5;2;4;2;2;6;6;5;3;5;4;3;3;4;3;5;2;4;4;5;7;4;5;4;4;6;6;5;5;5;2;4;6;5;4;4;3;3;6;3;8;5;4;5;5;5;7;6;5;2;5;2;7;6;5;2;3;5;5;3;6;7;8;5;4;6;3;5;3;2;3;4;4;6;4;4;5;4;6;6;4;7;5;5;4;5;4;8;4;5;8;4;4;3;5;5;6;2;6;3;3;6;1;2;8;7;5;7;8;7;4;4;2;6;5;5;5;5;7;2;6;3;6;6;5;5;7;5;4;5;8;6;5;5;5;4;4;4;6;5;5;5;4;3;5;5;4;4;5;6;5;3;4;7;4;5;4;5; GO:0034358;GO:0005788;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0070062;GO:0005615;GO:0070013;GO:0005768;GO:0005769;GO:0034361;GO:0034364;GO:0043230;GO:0043231;GO:0043233;GO:0005829;GO:0072562;GO:0044432;GO:0034385;GO:1990777;GO:0005783;GO:0031974;GO:0005773;GO:0043229;GO:0043227;GO:0043226;GO:0042627;GO:0012505;GO:0044446;GO:0044444;GO:0031982;GO:0005737;GO:0005623;GO:0005622;GO:1903561;GO:0032994;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;endoplasmic reticulum lumen;intracellular part;extracellular region part;organelle part;cell part;extracellular exosome;extracellular space;intracellular organelle lumen;endosome;early endosome;very-low-density lipoprotein particle;high-density lipoprotein particle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;blood microparticle;endoplasmic reticulum part;triglyceride-rich lipoprotein particle;lipoprotein particle;endoplasmic reticulum;membrane-enclosed lumen;vacuole;intracellular organelle;membrane-bounded organelle;organelle;chylomicron;endomembrane system;intracellular organelle part;cytoplasmic part;vesicle;cytoplasm;cell;intracellular;extracellular vesicle;protein-lipid complex;macromolecular complex;cellular_component;extracellular region; 3;5;3;2;2;2;4;3;4;4;5;5;4;3;4;3;5;3;4;4;4;4;2;5;3;3;2;4;3;3;4;4;4;2;3;3;3;2;1;2; GO:0098772;GO:0005488;GO:0005507;GO:0008289;GO:0017127;GO:0050997;GO:0070405;GO:0005543;GO:0005319;GO:0016209;GO:0046914;GO:0022892;GO:0046983;GO:0005215;GO:0005515;GO:0008047;GO:0046872;GO:0003674;GO:0097159;GO:0043168;GO:0043169;GO:0043167;GO:0042802;GO:0042803;GO:0030234;GO:0036094;GO:0005496;GO:0032934;GO:0015485;GO:0015248;GO:0043178;GO:0060228;GO:0031210; molecular function regulator;binding;copper ion binding;lipid binding;cholesterol transporter activity;quaternary ammonium group binding;ammonium ion binding;phospholipid binding;lipid transporter activity;antioxidant activity;transition metal ion binding;substrate-specific transporter activity;protein dimerization activity;transporter activity;protein binding;enzyme activator activity;metal ion binding;molecular_function;organic cyclic compound binding;anion binding;cation binding;ion binding;identical protein binding;protein homodimerization activity;enzyme regulator activity;small molecule binding;steroid binding;sterol binding;cholesterol binding;sterol transporter activity;alcohol binding;phosphatidylcholine-sterol O-acyltransferase activator activity;phosphatidylcholine binding; 2;2;7;3;6;3;5;4;4;2;6;3;4;2;3;4;5;1;3;4;4;3;4;5;3;3;4;5;6;5;4;5;4; K08760 map04975;map04977; Fat digestion and absorption;Vitamin digestion and absorption; IPR000074; Apolipoprotein A/E; extracellular 328954195 57.4 D [D] Cell cycle control, cell division, chromosome partitioning; COG1196 Chromosome segregation ATPase O94761 ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2 - [RECQ4_HUMAN] 0.932 1.253 0.895 1.013 1.177 0.871 0.743814844 nan 0.860662702 nan 0.714285714 nan 0.740016992 nan GO:1901360;GO:0044710;GO:0006260;GO:0032392;GO:0006281;GO:0046483;GO:0044707;GO:0033554;GO:0071103;GO:0006807;GO:1901576;GO:0044260;GO:0016043;GO:0071840;GO:0006139;GO:0051716;GO:0006950;GO:0008150;GO:0008152;GO:0050896;GO:0000733;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0032502;GO:0006310;GO:0032501;GO:0032508;GO:0009987;GO:0006974;GO:0051276;GO:0043170;GO:0090304;GO:0006725;GO:0007275;GO:0071704;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0006996;GO:0044238;GO:0048856;GO:0044237;GO:0006259; organic cyclic compound metabolic process;single-organism metabolic process;DNA replication;DNA geometric change;DNA repair;heterocycle metabolic process;single-multicellular organism process;cellular response to stress;DNA conformation change;nitrogen compound metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;cellular component organization or biogenesis;nucleobase-containing compound metabolic process;cellular response to stimulus;response to stress;biological_process;metabolic process;response to stimulus;DNA strand renaturation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;developmental process;DNA recombination;multicellular organismal process;DNA duplex unwinding;cellular process;cellular response to DNA damage stimulus;chromosome organization;macromolecule metabolic process;nucleic acid metabolic process;cellular aromatic compound metabolic process;multicellular organism development;organic substance metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;organelle organization;primary metabolic process;anatomical structure development;cellular metabolic process;DNA metabolic process; 4;3;6;7;4;4;3;4;6;3;4;4;3;2;4;3;3;1;2;2;6;4;4;5;2;2;6;2;8;2;5;5;4;5;4;4;3;3;3;5;3;4;3;3;3;5; GO:0016020;GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005575; membrane;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasm;nucleus;cell part;cell;cellular_component; 2;4;3;3;3;3;2;4;5;2;2;1; GO:0008270;GO:1901363;GO:0000166;GO:0046872;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0043138;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0003678;GO:1901265;GO:0042623;GO:0043140;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0008094;GO:0000405;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008026;GO:0035639;GO:0043169;GO:0043566;GO:0043167;GO:0000217;GO:0030554;GO:0016887;GO:0036094;GO:0097617;GO:0001883;GO:0001882;GO:0004003;GO:0017111;GO:0036310;GO:0046914;GO:0043168; zinc ion binding;heterocyclic compound binding;nucleotide binding;metal ion binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;3'-5' DNA helicase activity;molecular_function;binding;nucleic acid binding;DNA binding;DNA helicase activity;nucleoside phosphate binding;ATPase activity, coupled;ATP-dependent 3'-5' DNA helicase activity;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;DNA-dependent ATPase activity;bubble DNA binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;cation binding;structure-specific DNA binding;ion binding;DNA secondary structure binding;adenyl nucleotide binding;ATPase activity;small molecule binding;annealing activity;purine nucleoside binding;nucleoside binding;ATP-dependent DNA helicase activity;nucleoside-triphosphatase activity;annealing helicase activity;transition metal ion binding;anion binding; 7;3;4;5;8;5;3;4;9;10;1;2;4;5;9;4;9;11;5;5;6;3;2;10;8;3;6;6;5;6;4;10;5;4;6;3;7;6;8;3;5;5;4;10;7;6;6;4; K10730 IPR004589;IPR011545;IPR001650;IPR021110;IPR014001;IPR027417; DNA helicase, ATP-dependent, RecQ type;DEAD/DEAH box helicase domain;Helicase, C-terminal;DNA replication/checkpoint protein;Helicase superfamily 1/2, ATP-binding domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs4759030 2438.0 L [L] Replication, recombination and repair; Q8IY17 Neuropathy target esterase OS=Homo sapiens OX=9606 GN=PNPLA6 PE=1 SV=3 - [PLPL6_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0072359;GO:0016042;GO:0046470;GO:0044237;GO:0006644;GO:0006807;GO:0044281;GO:0009653;GO:0007275;GO:0044699;GO:0006650;GO:0044710;GO:0001525;GO:0071704;GO:0097164;GO:0001944;GO:0006796;GO:0048513;GO:0048514;GO:0019637;GO:0044255;GO:0048646;GO:0032502;GO:0009887;GO:0032501;GO:0006629;GO:0009308;GO:0001568;GO:0044712;GO:0009987;GO:1901575;GO:0044767;GO:0044106;GO:0008150;GO:0008152;GO:1901564;GO:0046486;GO:0009056;GO:0044238;GO:0042439;GO:0044707;GO:0048856;GO:0034641;GO:0044763;GO:0072358;GO:0006066;GO:0006793;GO:0048731;GO:0006576;GO:1901615; circulatory system development;lipid catabolic process;phosphatidylcholine metabolic process;cellular metabolic process;phospholipid metabolic process;nitrogen compound metabolic process;small molecule metabolic process;anatomical structure morphogenesis;multicellular organism development;single-organism process;glycerophospholipid metabolic process;single-organism metabolic process;angiogenesis;organic substance metabolic process;ammonium ion metabolic process;vasculature development;phosphate-containing compound metabolic process;animal organ development;blood vessel morphogenesis;organophosphate metabolic process;cellular lipid metabolic process;anatomical structure formation involved in morphogenesis;developmental process;organ morphogenesis;multicellular organismal process;lipid metabolic process;amine metabolic process;blood vessel development;single-organism catabolic process;cellular process;organic substance catabolic process;single-organism developmental process;cellular amine metabolic process;biological_process;metabolic process;organonitrogen compound metabolic process;glycerolipid metabolic process;catabolic process;primary metabolic process;ethanolamine-containing compound metabolic process;single-multicellular organism process;anatomical structure development;cellular nitrogen compound metabolic process;single-organism cellular process;cardiovascular system development;alcohol metabolic process;phosphorus metabolic process;system development;cellular biogenic amine metabolic process;organic hydroxy compound metabolic process; 5;5;5;3;5;3;4;3;4;2;6;3;4;3;4;5;5;4;4;4;4;3;2;4;2;4;5;4;4;2;4;3;5;1;2;4;5;3;3;4;3;3;4;3;5;5;4;4;6;4; GO:0005783;GO:0005789;GO:0042175;GO:0043229;GO:0043227;GO:0005737;GO:0044446;GO:0031090;GO:0016021;GO:0016020;GO:0043226;GO:0044432;GO:0031224;GO:0098588;GO:0012505;GO:0044425;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422; endoplasmic reticulum;endoplasmic reticulum membrane;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;membrane-bounded organelle;cytoplasm;intracellular organelle part;organelle membrane;integral component of membrane;membrane;organelle;endoplasmic reticulum part;intrinsic component of membrane;bounding membrane of organelle;endomembrane system;membrane part;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part; 4;3;3;3;3;4;3;3;4;2;2;4;3;4;3;2;4;2;2;3;1;4;3;2; GO:0003674;GO:0052689;GO:0016787;GO:0016788;GO:0003824;GO:0016298;GO:0004620;GO:0004622; molecular_function;carboxylic ester hydrolase activity;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;lipase activity;phospholipase activity;lysophospholipase activity; 1;5;3;4;2;5;6;6; K14676 map00564; Glycerophospholipid metabolism; IPR001423;IPR014710;IPR016035;IPR002641;IPR018490;IPR000595; Lysophospholipase patatin, conserved site;RmlC-like jelly roll fold;Acyl transferase/acyl hydrolase/lysophospholipase;Patatin-like phospholipase domain;Cyclic nucleotide-binding-like;Cyclic nucleotide-binding domain; plasma membrane Hs5729951 2700.0 R [R] General function prediction only; Q8IY18 Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2 - [SMC5_HUMAN] 0.994 1.032 1.035 1.212 0.903 1.181 0.963178295 nan 1.342192691 nan 1.002906977 nan 1.30786268 nan GO:0032436;GO:0080090;GO:0019222;GO:0010564;GO:0010965;GO:0018193;GO:0071840;GO:0051716;GO:0032434;GO:0048869;GO:0060249;GO:0070647;GO:0032446;GO:0034088;GO:0048518;GO:0007088;GO:0007063;GO:0006281;GO:0060255;GO:0030162;GO:0030163;GO:0007568;GO:1902099;GO:0046483;GO:1903364;GO:0019538;GO:0010638;GO:0034641;GO:0051783;GO:0051781;GO:0051785;GO:0044784;GO:0009896;GO:0045840;GO:0009894;GO:0045842;GO:0009893;GO:0034093;GO:0050789;GO:0007064;GO:0007067;GO:0043170;GO:0007062;GO:0044267;GO:0007346;GO:0044260;GO:0016043;GO:0065007;GO:0044699;GO:1901800;GO:0065008;GO:0034184;GO:0051130;GO:0000723;GO:0045876;GO:0034091;GO:0033554;GO:0000722;GO:0044710;GO:0050794;GO:1901987;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0007059;GO:0006302;GO:1901989;GO:0051603;GO:0050896;GO:0010498;GO:0043412;GO:0045732;GO:0006511;GO:1901970;GO:2001252;GO:0033044;GO:0033045;GO:0033047;GO:0033043;GO:0051246;GO:0051128;GO:0044248;GO:0042176;GO:1901990;GO:1901992;GO:0007049;GO:0006139;GO:0018205;GO:0000725;GO:0000724;GO:0043161;GO:0000280;GO:0051247;GO:0042592;GO:0032270;GO:0032502;GO:0006310;GO:1903052;GO:0031331;GO:1903050;GO:0009987;GO:0019941;GO:0006974;GO:0006508;GO:0044257;GO:0051984;GO:0016925;GO:0051983;GO:0090304;GO:0032268;GO:0000819;GO:0007569;GO:0098813;GO:0006807;GO:0045862;GO:0044767;GO:0031329;GO:0031325;GO:0031323;GO:0010604;GO:1903047;GO:0032200;GO:0044770;GO:0044772;GO:0022402;GO:0006725;GO:0051306;GO:0043632;GO:0051304;GO:0051302;GO:0051301;GO:1901360;GO:0030071;GO:0071704;GO:0043687;GO:0045931;GO:0000278;GO:1903362;GO:0090068;GO:0061136;GO:1901575;GO:0006464;GO:0044265;GO:0044763;GO:0034182;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0006312;GO:0000070;GO:0051276;GO:0051726;GO:0090398;GO:0045787;GO:0044237;GO:1902589;GO:0048285;GO:1902101;GO:0006259;GO:0007091;GO:0034086;GO:0048522; positive regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of cell cycle process;regulation of mitotic sister chromatid separation;peptidyl-amino acid modification;cellular component organization or biogenesis;cellular response to stimulus;regulation of proteasomal ubiquitin-dependent protein catabolic process;cellular developmental process;anatomical structure homeostasis;protein modification by small protein conjugation or removal;protein modification by small protein conjugation;maintenance of mitotic sister chromatid cohesion;positive regulation of biological process;regulation of mitotic nuclear division;regulation of sister chromatid cohesion;DNA repair;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;aging;regulation of metaphase/anaphase transition of cell cycle;heterocycle metabolic process;positive regulation of cellular protein catabolic process;protein metabolic process;positive regulation of organelle organization;cellular nitrogen compound metabolic process;regulation of nuclear division;positive regulation of cell division;positive regulation of nuclear division;metaphase/anaphase transition of cell cycle;positive regulation of catabolic process;positive regulation of mitotic nuclear division;regulation of catabolic process;positive regulation of mitotic metaphase/anaphase transition;positive regulation of metabolic process;positive regulation of maintenance of sister chromatid cohesion;regulation of biological process;mitotic sister chromatid cohesion;mitotic nuclear division;macromolecule metabolic process;sister chromatid cohesion;cellular protein metabolic process;regulation of mitotic cell cycle;cellular macromolecule metabolic process;cellular component organization;biological regulation;single-organism process;positive regulation of proteasomal protein catabolic process;regulation of biological quality;positive regulation of maintenance of mitotic sister chromatid cohesion;positive regulation of cellular component organization;telomere maintenance;positive regulation of sister chromatid cohesion;regulation of maintenance of sister chromatid cohesion;cellular response to stress;telomere maintenance via recombination;single-organism metabolic process;regulation of cellular process;regulation of cell cycle phase transition;response to stress;protein modification process;biological_process;metabolic process;chromosome segregation;double-strand break repair;positive regulation of cell cycle phase transition;proteolysis involved in cellular protein catabolic process;response to stimulus;proteasomal protein catabolic process;macromolecule modification;positive regulation of protein catabolic process;ubiquitin-dependent protein catabolic process;positive regulation of mitotic sister chromatid separation;positive regulation of chromosome organization;regulation of chromosome organization;regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;regulation of organelle organization;regulation of protein metabolic process;regulation of cellular component organization;cellular catabolic process;regulation of protein catabolic process;regulation of mitotic cell cycle phase transition;positive regulation of mitotic cell cycle phase transition;cell cycle;nucleobase-containing compound metabolic process;peptidyl-lysine modification;recombinational repair;double-strand break repair via homologous recombination;proteasome-mediated ubiquitin-dependent protein catabolic process;nuclear division;positive regulation of protein metabolic process;homeostatic process;positive regulation of cellular protein metabolic process;developmental process;DNA recombination;positive regulation of proteolysis involved in cellular protein catabolic process;positive regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;cellular response to DNA damage stimulus;proteolysis;cellular protein catabolic process;positive regulation of chromosome segregation;protein sumoylation;regulation of chromosome segregation;nucleic acid metabolic process;regulation of cellular protein metabolic process;sister chromatid segregation;cell aging;nuclear chromosome segregation;nitrogen compound metabolic process;positive regulation of proteolysis;single-organism developmental process;regulation of cellular catabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of macromolecule metabolic process;mitotic cell cycle process;telomere organization;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;cellular aromatic compound metabolic process;mitotic sister chromatid separation;modification-dependent macromolecule catabolic process;chromosome separation;regulation of cell division;cell division;organic cyclic compound metabolic process;regulation of mitotic metaphase/anaphase transition;organic substance metabolic process;post-translational protein modification;positive regulation of mitotic cell cycle;mitotic cell cycle;regulation of cellular protein catabolic process;positive regulation of cell cycle process;regulation of proteasomal protein catabolic process;organic substance catabolic process;cellular protein modification process;cellular macromolecule catabolic process;single-organism cellular process;regulation of maintenance of mitotic sister chromatid cohesion;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;mitotic recombination;mitotic sister chromatid segregation;chromosome organization;regulation of cell cycle;cellular senescence;positive regulation of cell cycle;cellular metabolic process;single-organism organelle organization;organelle fission;positive regulation of metaphase/anaphase transition of cell cycle;DNA metabolic process;metaphase/anaphase transition of mitotic cell cycle;maintenance of sister chromatid cohesion;positive regulation of cellular process; 8;4;3;5;7;7;2;3;8;4;5;7;8;6;2;6;6;4;4;6;5;4;6;4;6;4;5;4;5;4;5;6;4;6;4;6;3;6;2;6;5;4;5;5;5;4;3;2;2;7;3;7;4;4;5;6;4;5;3;3;6;3;5;1;2;4;5;6;6;2;6;5;5;8;5;6;6;5;6;5;5;4;4;5;6;6;4;4;8;5;6;7;6;5;4;5;2;6;7;5;7;2;7;5;5;6;4;9;4;5;5;5;5;5;3;6;3;5;4;4;4;5;6;5;6;4;4;6;6;5;4;4;4;7;3;7;5;5;6;5;7;4;6;5;3;7;3;5;4;3;7;6;5;4;5;4;3;4;5;7;5;6;5;3; GO:0035061;GO:0031974;GO:0031981;GO:0030915;GO:0000793;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0030054;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0000781;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0016604;GO:0005654;GO:0098687;GO:0044446;GO:0005634;GO:0044451;GO:0016605;GO:0044464;GO:0005623;GO:0005622;GO:0035861;GO:0005694;GO:0000803;GO:0032991;GO:0005575;GO:0070013; interchromatin granule;membrane-enclosed lumen;nuclear lumen;Smc5-Smc6 complex;condensed chromosome;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell junction;nuclear part;intracellular part;chromosomal part;organelle part;chromosome, telomeric region;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;nuclear body;nucleoplasm;chromosomal region;intracellular organelle part;nucleus;nucleoplasm part;PML body;cell part;cell;intracellular;site of double-strand break;chromosome;sex chromosome;macromolecular complex;cellular_component;intracellular organelle lumen; 7;2;5;4;6;3;4;4;3;2;4;3;4;2;6;3;3;3;2;6;5;5;3;5;5;7;2;2;3;5;5;6;2;1;4; GO:1901363;GO:0000166;GO:0032549;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0017076;GO:0005524;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0043167;GO:0030554;GO:0001882;GO:0001883;GO:0036094; heterocyclic compound binding;nucleotide binding;ribonucleoside binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;purine nucleotide binding;ATP binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;ion binding;adenyl nucleotide binding;nucleoside binding;purine nucleoside binding;small molecule binding; 3;4;5;3;1;2;4;5;6;3;6;5;6;4;5;4;3;6;4;5;3; K22803 IPR027131;IPR027417;IPR003395; Structural maintenance of chromosomes protein 5;P-loop containing nucleoside triphosphate hydrolase;RecF/RecN/SMC, N-terminal; nucleus Hs20540945_1 1342.0 BDL [B] Chromatin structure and dynamics;[D] Cell cycle control, cell division, chromosome partitioning;[L] Replication, recombination and repair; Q96IY4 Carboxypeptidase B2 OS=Homo sapiens OX=9606 GN=CPB2 PE=1 SV=2 - [CBPB2_HUMAN] 0.961 1.003 1.181 0.905 1.04 1.247 0.958125623 0.158768268 0.870192308 0.027581902 1.177467597 0.011507718 1.199038462 0.008574223 GO:0001678;GO:0007599;GO:0080090;GO:0051046;GO:0051047;GO:0051049;GO:0048585;GO:0007596;GO:0048583;GO:0050680;GO:0033500;GO:0071840;GO:0032103;GO:0051716;GO:0010605;GO:0009611;GO:0048513;GO:0071331;GO:0071333;GO:0048518;GO:0048519;GO:0019725;GO:0048584;GO:0051050;GO:0060255;GO:0030162;GO:0010033;GO:0009605;GO:0044707;GO:0034284;GO:0019538;GO:0071322;GO:0071326;GO:0048878;GO:0030198;GO:0030193;GO:0030195;GO:0030194;GO:0009892;GO:0061008;GO:0050820;GO:0032940;GO:0050673;GO:0050789;GO:0044267;GO:0044260;GO:0016043;GO:1900046;GO:1900047;GO:0065007;GO:0065008;GO:0022603;GO:0051130;GO:0009887;GO:0050793;GO:0006810;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:0009266;GO:0051234;GO:0050818;GO:0050819;GO:0046903;GO:0070613;GO:0072576;GO:0051604;GO:0072574;GO:0003331;GO:0003330;GO:0050896;GO:1901701;GO:1903318;GO:1903317;GO:0032102;GO:0008152;GO:0032101;GO:0051246;GO:0071310;GO:1900048;GO:0070278;GO:0051128;GO:1903530;GO:0070887;GO:1903532;GO:0009653;GO:0044699;GO:0051248;GO:0008283;GO:2000345;GO:0051240;GO:0051241;GO:0031099;GO:0051917;GO:0006508;GO:1903034;GO:1903035;GO:1903036;GO:0032502;GO:0009746;GO:0032501;GO:0050878;GO:0044238;GO:1903053;GO:0009987;GO:0042730;GO:1903055;GO:0022612;GO:0016485;GO:0009408;GO:0055082;GO:0032879;GO:0009743;GO:0051093;GO:0032269;GO:0032268;GO:0050678;GO:0072575;GO:0042493;GO:0010629;GO:0043170;GO:0051918;GO:0097421;GO:0048731;GO:0048732;GO:0080134;GO:0042127;GO:2000346;GO:0060341;GO:0008285;GO:0031324;GO:0031323;GO:0045861;GO:0042592;GO:0042593;GO:0061041;GO:0001889;GO:0061045;GO:0090303;GO:0007275;GO:0031100;GO:0031639;GO:0031638;GO:0071704;GO:0010467;GO:0043062;GO:2000026;GO:0010468;GO:0044767;GO:0044765;GO:0044763;GO:0042221;GO:0019222;GO:0010955;GO:0051179;GO:1902578;GO:0051641;GO:1901700;GO:0009628;GO:0048856;GO:0044237;GO:0009749;GO:0010757;GO:2000027;GO:0010755;GO:0048523;GO:0048522; cellular glucose homeostasis;hemostasis;regulation of primary metabolic process;regulation of secretion;positive regulation of secretion;regulation of transport;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;negative regulation of epithelial cell proliferation;carbohydrate homeostasis;cellular component organization or biogenesis;positive regulation of response to external stimulus;cellular response to stimulus;negative regulation of macromolecule metabolic process;response to wounding;animal organ development;cellular response to hexose stimulus;cellular response to glucose stimulus;positive regulation of biological process;negative regulation of biological process;cellular homeostasis;positive regulation of response to stimulus;positive regulation of transport;regulation of macromolecule metabolic process;regulation of proteolysis;response to organic substance;response to external stimulus;single-multicellular organism process;response to monosaccharide;protein metabolic process;cellular response to carbohydrate stimulus;cellular response to monosaccharide stimulus;chemical homeostasis;extracellular matrix organization;regulation of blood coagulation;negative regulation of blood coagulation;positive regulation of blood coagulation;negative regulation of metabolic process;hepaticobiliary system development;positive regulation of coagulation;secretion by cell;epithelial cell proliferation;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;regulation of hemostasis;negative regulation of hemostasis;biological regulation;regulation of biological quality;regulation of anatomical structure morphogenesis;positive regulation of cellular component organization;organ morphogenesis;regulation of developmental process;transport;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;regulation of multicellular organismal process;response to temperature stimulus;establishment of localization;regulation of coagulation;negative regulation of coagulation;secretion;regulation of protein processing;liver morphogenesis;protein maturation;hepatocyte proliferation;positive regulation of extracellular matrix constituent secretion;regulation of extracellular matrix constituent secretion;response to stimulus;cellular response to oxygen-containing compound;negative regulation of protein maturation;regulation of protein maturation;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;regulation of protein metabolic process;cellular response to organic substance;positive regulation of hemostasis;extracellular matrix constituent secretion;regulation of cellular component organization;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;anatomical structure morphogenesis;single-organism process;negative regulation of protein metabolic process;cell proliferation;regulation of hepatocyte proliferation;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regeneration;regulation of fibrinolysis;proteolysis;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;developmental process;response to hexose;multicellular organismal process;regulation of body fluid levels;primary metabolic process;regulation of extracellular matrix organization;cellular process;fibrinolysis;positive regulation of extracellular matrix organization;gland morphogenesis;protein processing;response to heat;cellular chemical homeostasis;regulation of localization;response to carbohydrate;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of epithelial cell proliferation;epithelial cell proliferation involved in liver morphogenesis;response to drug;negative regulation of gene expression;macromolecule metabolic process;negative regulation of fibrinolysis;liver regeneration;system development;gland development;regulation of response to stress;regulation of cell proliferation;negative regulation of hepatocyte proliferation;regulation of cellular localization;negative regulation of cell proliferation;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of proteolysis;homeostatic process;glucose homeostasis;regulation of wound healing;liver development;negative regulation of wound healing;positive regulation of wound healing;multicellular organism development;organ regeneration;plasminogen activation;zymogen activation;organic substance metabolic process;gene expression;extracellular structure organization;regulation of multicellular organismal development;regulation of gene expression;single-organism developmental process;single-organism transport;single-organism cellular process;response to chemical;regulation of metabolic process;negative regulation of protein processing;localization;single-organism localization;cellular localization;response to oxygen-containing compound;response to abiotic stimulus;anatomical structure development;cellular metabolic process;response to glucose;negative regulation of plasminogen activation;regulation of organ morphogenesis;regulation of plasminogen activation;negative regulation of cellular process;positive regulation of cellular process; 6;5;4;5;4;4;3;5;3;5;6;2;4;3;4;4;4;8;7;2;2;4;3;3;4;6;4;3;3;6;4;6;7;5;5;5;5;5;3;5;4;4;4;2;5;4;3;4;4;2;3;4;4;4;3;4;5;3;3;4;1;3;4;3;4;4;5;7;6;5;6;5;6;2;5;6;6;4;2;4;5;5;4;5;4;5;4;4;3;2;5;3;6;3;3;4;6;5;5;4;4;2;7;2;4;3;5;2;6;5;5;6;4;5;3;5;3;5;5;5;5;4;5;4;3;6;4;4;4;4;4;4;4;4;4;6;4;7;6;5;5;5;4;5;8;7;3;5;4;4;5;3;4;3;3;3;7;2;3;3;4;3;3;3;8;8;5;8;3;3; GO:0031982;GO:0005615;GO:0043230;GO:0044421;GO:0043227;GO:0005623;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576; vesicle;extracellular space;extracellular organelle;extracellular region part;membrane-bounded organelle;cell;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region; 4;3;3;2;3;2;4;2;3;1;2; GO:0004180;GO:0008270;GO:0046872;GO:0003674;GO:0005488;GO:0008237;GO:0016787;GO:0003824;GO:0008238;GO:0008233;GO:0008235;GO:0043169;GO:0043167;GO:0004181;GO:0070011;GO:0046914; carboxypeptidase activity;zinc ion binding;metal ion binding;molecular_function;binding;metallopeptidase activity;hydrolase activity;catalytic activity;exopeptidase activity;peptidase activity;metalloexopeptidase activity;cation binding;ion binding;metallocarboxypeptidase activity;peptidase activity, acting on L-amino acid peptides;transition metal ion binding; 7;7;5;1;2;6;3;2;6;4;7;4;3;8;5;6; K01300 map04610;map04972;map04974; Complement and coagulation cascades;Pancreatic secretion;Protein digestion and absorption; IPR000834;IPR003146;IPR033849;IPR009020; Peptidase M14, carboxypeptidase A;Carboxypeptidase, activation peptide;Carboxypeptidase B2;Protease propeptides/proteinase inhibitor I9; extracellular Hs4503005 881.0 S [S] Function unknown; Q9UGM5 Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2 - [FETUB_HUMAN] 1.11 0.966 0.907 1.106 0.97 1.052 1.149068323 0.00145311 1.140206186 0.003595986 0.938923395 0.875241052 1.084536082 0.191813954 GO:0009892;GO:0019222;GO:0031324;GO:0031323;GO:0019953;GO:0050789;GO:0008152;GO:0044699;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0019538;GO:0048519;GO:0065009;GO:0051704;GO:0008037;GO:0009988;GO:0052547;GO:0052548;GO:0009987;GO:0035036;GO:0050794;GO:0030162;GO:0022414;GO:0032268;GO:0008150;GO:0007338;GO:0006508;GO:0010951;GO:0051346;GO:0000003;GO:0051336;GO:0044238;GO:0044703;GO:0044702;GO:0050790;GO:0060255;GO:0009566;GO:0044237;GO:0043170;GO:0044763;GO:0032269;GO:0007339;GO:0045861;GO:0048523; negative regulation of metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;sexual reproduction;regulation of biological process;metabolic process;single-organism process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;protein metabolic process;negative regulation of biological process;regulation of molecular function;multi-organism process;cell recognition;cell-cell recognition;regulation of peptidase activity;regulation of endopeptidase activity;cellular process;sperm-egg recognition;regulation of cellular process;regulation of proteolysis;reproductive process;regulation of cellular protein metabolic process;biological_process;single fertilization;proteolysis;negative regulation of endopeptidase activity;negative regulation of hydrolase activity;reproduction;regulation of hydrolase activity;primary metabolic process;multi-organism reproductive process;single organism reproductive process;regulation of catalytic activity;regulation of macromolecule metabolic process;fertilization;cellular metabolic process;macromolecule metabolic process;single-organism cellular process;negative regulation of cellular protein metabolic process;binding of sperm to zona pellucida;negative regulation of proteolysis;negative regulation of cellular process; 3;3;4;4;3;2;2;2;4;5;5;4;4;5;5;3;7;2;4;4;2;3;2;4;5;6;7;2;4;3;6;2;5;1;5;5;8;6;2;5;3;3;3;4;4;4;3;4;3;5;5;6;3; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0031982;GO:1903561;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;vesicle;extracellular vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;4;3;3;1;2;2; GO:0030414;GO:0061135;GO:0003674;GO:0004869;GO:0004857;GO:0098772;GO:0061134;GO:0030234;GO:0004866;GO:0008191; peptidase inhibitor activity;endopeptidase regulator activity;molecular_function;cysteine-type endopeptidase inhibitor activity;enzyme inhibitor activity;molecular function regulator;peptidase regulator activity;enzyme regulator activity;endopeptidase inhibitor activity;metalloendopeptidase inhibitor activity; 5;5;1;7;4;2;4;3;6;7; K23411 IPR000010;IPR025764;IPR001363; Cystatin domain;Fetuin-B-type cystatin domain;Proteinase inhibitor I25C, fetuin, conserved site; extracellular A0A1B0GVH7 IQ domain-containing protein M OS=Homo sapiens OX=9606 GN=IQCM PE=4 SV=1 - [IQCM_HUMAN] 1.098 1.241 0.733 0.999 1.314 0.485 0.884770346 0.000105106 0.760273973 2.15E-05 0.590652699 9.31E-11 0.369101979 4.78E-08 IPR000048; IQ motif, EF-hand binding site; cytosol, nucleus P40197 Platelet glycoprotein V OS=Homo sapiens OX=9606 GN=GP5 PE=1 SV=1 - [GPV_HUMAN] 0.704 1.203 1.546 0.645 0.794 1.52 0.585203658 nan 0.812342569 nan 1.285120532 nan 1.914357683 nan GO:0032990;GO:0048666;GO:0007599;GO:0007409;GO:0030030;GO:0007597;GO:0007596;GO:0048468;GO:0031175;GO:0030182;GO:0009653;GO:0044699;GO:0000902;GO:0044710;GO:0000904;GO:0072376;GO:0072378;GO:0001775;GO:0009611;GO:0016043;GO:0007275;GO:0071704;GO:0048812;GO:0065007;GO:0071840;GO:0065008;GO:0032502;GO:0048667;GO:0032501;GO:0061564;GO:0050878;GO:0009987;GO:0042060;GO:0044767;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0048731;GO:0007155;GO:0022008;GO:0030168;GO:0044238;GO:0048699;GO:0022610;GO:0048858;GO:0044707;GO:0019538;GO:0050896;GO:0048856;GO:0007399;GO:0043170;GO:0032989;GO:0048869;GO:0030154;GO:0044763; cell part morphogenesis;neuron development;hemostasis;axonogenesis;cell projection organization;blood coagulation, intrinsic pathway;blood coagulation;cell development;neuron projection development;neuron differentiation;anatomical structure morphogenesis;single-organism process;cell morphogenesis;single-organism metabolic process;cell morphogenesis involved in differentiation;protein activation cascade;blood coagulation, fibrin clot formation;cell activation;response to wounding;cellular component organization;multicellular organism development;organic substance metabolic process;neuron projection morphogenesis;biological regulation;cellular component organization or biogenesis;regulation of biological quality;developmental process;cell morphogenesis involved in neuron differentiation;multicellular organismal process;axon development;regulation of body fluid levels;cellular process;wound healing;single-organism developmental process;response to stress;coagulation;biological_process;metabolic process;system development;cell adhesion;neurogenesis;platelet activation;primary metabolic process;generation of neurons;biological adhesion;cell projection morphogenesis;single-multicellular organism process;protein metabolic process;response to stimulus;anatomical structure development;nervous system development;macromolecule metabolic process;cellular component morphogenesis;cellular developmental process;cell differentiation;single-organism cellular process; 5;5;5;7;4;4;5;4;5;6;3;2;5;3;5;3;4;4;4;3;4;3;6;2;2;3;2;6;2;6;4;2;5;3;3;4;1;2;4;3;6;5;3;7;2;5;3;4;2;3;5;4;4;4;5;3; GO:0031226;GO:0031224;GO:0071944;GO:0043227;GO:0043226;GO:0070062;GO:0016021;GO:0016020;GO:0005886;GO:0044425;GO:0044459;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005575;GO:0005576;GO:0005887;GO:0044421; intrinsic component of plasma membrane;intrinsic component of membrane;cell periphery;membrane-bounded organelle;organelle;extracellular exosome;integral component of membrane;membrane;plasma membrane;membrane part;plasma membrane part;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;cellular_component;extracellular region;integral component of plasma membrane;extracellular region part; 4;3;3;3;2;4;4;2;3;2;3;3;4;3;2;2;1;2;4;2; K06260 map04512;map04611;map04640; ECM-receptor interaction;Platelet activation;Hematopoietic cell lineage; IPR003591;IPR001611;IPR000483;IPR032675; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat domain, L domain-like; extracellular Hs4758460 1106.0 R [R] General function prediction only; Q96BY7 Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5 - [ATG2B_HUMAN] 0.929 0.725 1.175 1.165 1.152 1.126 1.28137931 nan 1.011284722 nan 1.620689655 nan 0.977430556 nan GO:0022607;GO:0016236;GO:1903008;GO:0007005;GO:0044699;GO:0044710;GO:0016043;GO:0000045;GO:1905037;GO:0071840;GO:0044712;GO:0061726;GO:0006914;GO:0009987;GO:0044804;GO:0022411;GO:0008152;GO:0070925;GO:0009056;GO:0006996;GO:0007033;GO:0000422;GO:0044763;GO:1902589;GO:0044085;GO:0008150; cellular component assembly;macroautophagy;organelle disassembly;mitochondrion organization;single-organism process;single-organism metabolic process;cellular component organization;autophagosome assembly;autophagosome organization;cellular component organization or biogenesis;single-organism catabolic process;mitochondrion disassembly;autophagy;cellular process;nucleophagy;cellular component disassembly;metabolic process;organelle assembly;catabolic process;organelle organization;vacuole organization;mitophagy;single-organism cellular process;single-organism organelle organization;cellular component biogenesis;biological_process; 4;4;5;5;2;3;3;6;5;2;4;6;3;2;4;4;2;5;3;4;5;4;3;4;3;1; GO:0019898;GO:0034045;GO:0043229;GO:0043228;GO:0043232;GO:0043227;GO:0043226;GO:0005737;GO:0016020;GO:0031090;GO:0098805;GO:0005811;GO:0044444;GO:0098588;GO:0044425;GO:0000407;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044422; extrinsic component of membrane;pre-autophagosomal structure membrane;intracellular organelle;non-membrane-bounded organelle;intracellular non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;membrane;organelle membrane;whole membrane;lipid particle;cytoplasmic part;bounding membrane of organelle;membrane part;pre-autophagosomal structure;cell part;cell;intracellular;cellular_component;intracellular part;organelle part; 3;4;3;3;4;3;2;4;2;3;3;5;4;4;2;5;2;2;3;1;3;2; K17906 IPR026849;IPR015412;IPR026885;IPR026854; Autophagy-related protein 2;Autophagy-related, C-terminal;Autophagy-related protein 2 CAD motif;Vacuolar protein sorting-associated protein 13, N-terminal domain; nucleus Hs20558378 1421.0 U [U] Intracellular trafficking, secretion, and vesicular transport; A0A087WSZ0 Immunoglobulin kappa variable 1D-8 OS=Homo sapiens OX=9606 GN=IGKV1D-8 PE=3 SV=6 - [KVD08_HUMAN] 0.832 1.067 1.312 0.683 1.061 1.326 0.779756326 6.83E-07 0.643732328 5.79E-10 1.229615745 0.003279389 1.249764373 0.001697435 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular A8K855 EF-hand calcium-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=EFCAB7 PE=1 SV=1 - [EFCB7_HUMAN] nan nan nan nan nan nan nan 0.359413709 nan 0.608668522 nan 0.079265253 nan 0.863014544 GO:0072372;GO:0044464;GO:0005623;GO:0005575;GO:0005929;GO:0042995;GO:0043226; primary cilium;cell part;cell;cellular_component;cilium;cell projection;organelle; 4;2;2;1;3;3;2; GO:0043169;GO:0043167;GO:0046872;GO:0003674;GO:0005509;GO:0005488; cation binding;ion binding;metal ion binding;molecular_function;calcium ion binding;binding; 4;3;5;1;6;2; IPR011992;IPR018247;IPR002048; EF-hand domain pair;EF-Hand 1, calcium-binding site;EF-hand domain; nucleus Hs17436802 1313.0 T [T] Signal transduction mechanisms; P36955 Pigment epithelium-derived factor OS=Homo sapiens OX=9606 GN=SERPINF1 PE=1 SV=4 - [PEDF_HUMAN] 1.039 1 1.06 1.02 0.982 1.013 1.039 0.214085196 1.038696538 0.020189304 1.06 0.010423984 1.031568228 0.024102415 GO:0001678;GO:0032025;GO:0044238;GO:0010975;GO:0019222;GO:2000242;GO:0007614;GO:2000241;GO:0048468;GO:0007613;GO:0007610;GO:0007611;GO:0031348;GO:0072358;GO:0065009;GO:0032102;GO:0055082;GO:0031347;GO:0031346;GO:0010035;GO:0010605;GO:0000003;GO:0071704;GO:0010447;GO:0048869;GO:0001822;GO:0048511;GO:0030850;GO:0048513;GO:0048514;GO:0071331;GO:0010720;GO:0071333;GO:0048518;GO:0048519;GO:0048585;GO:0040011;GO:0042127;GO:0040013;GO:0060255;GO:1901701;GO:0001667;GO:0050680;GO:0003006;GO:0030162;GO:0010038;GO:0007568;GO:0010033;GO:0003008;GO:0044702;GO:0009605;GO:0044707;GO:0034284;GO:0019538;GO:0044708;GO:0048870;GO:0071326;GO:0048878;GO:0042698;GO:0071322;GO:0051128;GO:0001101;GO:0051130;GO:0009892;GO:0022603;GO:0006928;GO:0010594;GO:0051271;GO:0010629;GO:0030334;GO:0031175;GO:0060770;GO:0043170;GO:0050789;GO:0043542;GO:0044267;GO:0051346;GO:0044260;GO:0070997;GO:0001568;GO:0016043;GO:0031344;GO:0065007;GO:0071840;GO:0065008;GO:0048646;GO:0071279;GO:0009719;GO:0050793;GO:0001944;GO:0050790;GO:0051716;GO:0050794;GO:0006952;GO:0060768;GO:0006950;GO:0008150;GO:0051239;GO:0009268;GO:1901214;GO:1901215;GO:0045861;GO:0060767;GO:0051336;GO:0007423;GO:0050896;GO:0050890;GO:0051962;GO:0051960;GO:2000145;GO:0016525;GO:0043010;GO:0097306;GO:0006954;GO:0072359;GO:0071248;GO:0008152;GO:0031960;GO:0032101;GO:0044092;GO:0030154;GO:0071241;GO:0009611;GO:1901655;GO:0060041;GO:0070887;GO:0016477;GO:0009653;GO:0010632;GO:0043086;GO:0044699;GO:0010631;GO:0050767;GO:0051248;GO:0051674;GO:0045664;GO:0051240;GO:0051241;GO:0051246;GO:0060284;GO:0050769;GO:0030030;GO:0045666;GO:0006508;GO:1903034;GO:1903035;GO:0071407;GO:0032502;GO:0008285;GO:0032501;GO:0048608;GO:0048609;GO:0032504;GO:0008283;GO:0050877;GO:2000146;GO:0009987;GO:0050727;GO:0071549;GO:0048583;GO:0045597;GO:0045595;GO:0050728;GO:0001654;GO:0001655;GO:0072001;GO:0010633;GO:0090132;GO:0090130;GO:0051093;GO:0032269;GO:0032268;GO:0050678;GO:0009746;GO:1901342;GO:0051094;GO:0009725;GO:0050673;GO:0014070;GO:0048731;GO:0048732;GO:0080134;GO:0048545;GO:0019725;GO:0051384;GO:2000181;GO:0071495;GO:0061458;GO:0071383;GO:0031324;GO:0031323;GO:0071384;GO:0071385;GO:0071229;GO:0042592;GO:0042593;GO:0044237;GO:0008219;GO:0010941;GO:0007275;GO:0001525;GO:0033993;GO:0033500;GO:0071310;GO:0010467;GO:0010466;GO:0040012;GO:0032879;GO:0060548;GO:0045765;GO:0046685;GO:0010468;GO:0048666;GO:0030336;GO:0032526;GO:0030182;GO:0052547;GO:0052548;GO:0071396;GO:0080090;GO:0044767;GO:0022414;GO:0044763;GO:0010951;GO:0042221;GO:0022008;GO:0051179;GO:1901700;GO:0009628;GO:0048699;GO:0071548;GO:0009743;GO:0007399;GO:0010596;GO:0097305;GO:0048856;GO:0051270;GO:0032870;GO:0010976;GO:0009749;GO:0071300;GO:1901654;GO:2000026;GO:1901343;GO:0048523;GO:0048522; cellular glucose homeostasis;response to cobalt ion;primary metabolic process;regulation of neuron projection development;regulation of metabolic process;negative regulation of reproductive process;short-term memory;regulation of reproductive process;cell development;memory;behavior;learning or memory;negative regulation of defense response;cardiovascular system development;regulation of molecular function;negative regulation of response to external stimulus;cellular chemical homeostasis;regulation of defense response;positive regulation of cell projection organization;response to inorganic substance;negative regulation of macromolecule metabolic process;reproduction;organic substance metabolic process;response to acidic pH;cellular developmental process;kidney development;rhythmic process;prostate gland development;animal organ development;blood vessel morphogenesis;cellular response to hexose stimulus;positive regulation of cell development;cellular response to glucose stimulus;positive regulation of biological process;negative regulation of biological process;negative regulation of response to stimulus;locomotion;regulation of cell proliferation;negative regulation of locomotion;regulation of macromolecule metabolic process;cellular response to oxygen-containing compound;ameboidal-type cell migration;negative regulation of epithelial cell proliferation;developmental process involved in reproduction;regulation of proteolysis;response to metal ion;aging;response to organic substance;system process;single organism reproductive process;response to external stimulus;single-multicellular organism process;response to monosaccharide;protein metabolic process;single-organism behavior;cell motility;cellular response to monosaccharide stimulus;chemical homeostasis;ovulation cycle;cellular response to carbohydrate stimulus;regulation of cellular component organization;response to acid chemical;positive regulation of cellular component organization;negative regulation of metabolic process;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;regulation of endothelial cell migration;negative regulation of cellular component movement;negative regulation of gene expression;regulation of cell migration;neuron projection development;negative regulation of epithelial cell proliferation involved in prostate gland development;macromolecule metabolic process;regulation of biological process;endothelial cell migration;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;neuron death;blood vessel development;cellular component organization;regulation of cell projection organization;biological regulation;cellular component organization or biogenesis;regulation of biological quality;anatomical structure formation involved in morphogenesis;cellular response to cobalt ion;response to endogenous stimulus;regulation of developmental process;vasculature development;regulation of catalytic activity;cellular response to stimulus;regulation of cellular process;defense response;regulation of epithelial cell proliferation involved in prostate gland development;response to stress;biological_process;regulation of multicellular organismal process;response to pH;regulation of neuron death;negative regulation of neuron death;negative regulation of proteolysis;epithelial cell proliferation involved in prostate gland development;regulation of hydrolase activity;sensory organ development;response to stimulus;cognition;positive regulation of nervous system development;regulation of nervous system development;regulation of cell motility;negative regulation of angiogenesis;camera-type eye development;cellular response to alcohol;inflammatory response;circulatory system development;cellular response to metal ion;metabolic process;response to corticosteroid;regulation of response to external stimulus;negative regulation of molecular function;cell differentiation;cellular response to inorganic substance;response to wounding;cellular response to ketone;retina development in camera-type eye;cellular response to chemical stimulus;cell migration;anatomical structure morphogenesis;regulation of epithelial cell migration;negative regulation of catalytic activity;single-organism process;epithelial cell migration;regulation of neurogenesis;negative regulation of protein metabolic process;localization of cell;regulation of neuron differentiation;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;regulation of cell development;positive regulation of neurogenesis;cell projection organization;positive regulation of neuron differentiation;proteolysis;regulation of response to wounding;negative regulation of response to wounding;cellular response to organic cyclic compound;developmental process;negative regulation of cell proliferation;multicellular organismal process;reproductive structure development;multicellular organismal reproductive process;multicellular organism reproduction;cell proliferation;neurological system process;negative regulation of cell motility;cellular process;regulation of inflammatory response;cellular response to dexamethasone stimulus;regulation of response to stimulus;positive regulation of cell differentiation;regulation of cell differentiation;negative regulation of inflammatory response;eye development;urogenital system development;renal system development;negative regulation of epithelial cell migration;epithelium migration;tissue migration;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of epithelial cell proliferation;response to hexose;regulation of vasculature development;positive regulation of developmental process;response to hormone;epithelial cell proliferation;response to organic cyclic compound;system development;gland development;regulation of response to stress;response to steroid hormone;cellular homeostasis;response to glucocorticoid;negative regulation of blood vessel morphogenesis;cellular response to endogenous stimulus;reproductive system development;cellular response to steroid hormone stimulus;negative regulation of cellular metabolic process;regulation of cellular metabolic process;cellular response to corticosteroid stimulus;cellular response to glucocorticoid stimulus;cellular response to acid chemical;homeostatic process;glucose homeostasis;cellular metabolic process;cell death;regulation of cell death;multicellular organism development;angiogenesis;response to lipid;carbohydrate homeostasis;cellular response to organic substance;gene expression;negative regulation of peptidase activity;regulation of locomotion;regulation of localization;negative regulation of cell death;regulation of angiogenesis;response to arsenic-containing substance;regulation of gene expression;neuron development;negative regulation of cell migration;response to retinoic acid;neuron differentiation;regulation of peptidase activity;regulation of endopeptidase activity;cellular response to lipid;regulation of primary metabolic process;single-organism developmental process;reproductive process;single-organism cellular process;negative regulation of endopeptidase activity;response to chemical;neurogenesis;localization;response to oxygen-containing compound;response to abiotic stimulus;generation of neurons;response to dexamethasone;response to carbohydrate;nervous system development;negative regulation of endothelial cell migration;response to alcohol;anatomical structure development;regulation of cellular component movement;cellular response to hormone stimulus;positive regulation of neuron projection development;response to glucose;cellular response to retinoic acid;response to ketone;regulation of multicellular organismal development;negative regulation of vasculature development;negative regulation of cellular process;positive regulation of cellular process; 6;6;3;6;3;3;6;3;4;5;2;4;4;5;3;4;5;5;5;4;4;2;3;5;4;4;2;4;4;4;8;5;7;2;2;3;2;4;3;4;5;5;5;3;6;5;4;4;3;3;3;3;6;4;3;3;7;5;3;6;4;4;4;3;4;4;5;4;5;5;5;4;4;2;7;5;6;4;5;4;3;5;2;2;3;3;7;3;3;5;4;3;3;4;4;3;1;3;4;5;5;6;4;5;4;2;5;4;5;4;5;6;6;5;5;6;2;6;4;4;5;5;4;6;4;4;4;3;4;5;2;6;6;5;3;7;3;3;5;5;5;4;6;5;5;4;6;2;4;2;4;3;3;3;4;4;2;5;7;3;4;4;5;5;5;5;4;5;4;3;5;5;5;7;5;3;4;4;5;4;4;4;5;4;7;5;4;5;6;4;4;7;8;5;4;7;3;4;4;4;4;5;6;5;5;7;3;3;4;5;4;5;5;5;5;6;6;7;6;4;3;2;3;8;3;6;2;4;3;7;6;5;5;5;5;3;4;5;6;8;6;5;4;4;3;3; GO:0016023;GO:0043203;GO:0031988;GO:0044297;GO:0036477;GO:0043231;GO:0042995;GO:0043230;GO:0044424;GO:0044420;GO:0044421;GO:0043227;GO:0048471;GO:0043025;GO:0097708;GO:0031982;GO:0042470;GO:0031012;GO:0044444;GO:0033267;GO:0043226;GO:0005737;GO:0031410;GO:0043005;GO:0048770;GO:0044463;GO:0044464;GO:0043229;GO:0005623;GO:0005604;GO:0005615;GO:0097458;GO:0030424;GO:0005622;GO:1903561;GO:0070062;GO:0005575;GO:0005576;GO:0005578; cytoplasmic, membrane-bounded vesicle;axon hillock;membrane-bounded vesicle;cell body;somatodendritic compartment;intracellular membrane-bounded organelle;cell projection;extracellular organelle;intracellular part;extracellular matrix component;extracellular region part;membrane-bounded organelle;perinuclear region of cytoplasm;neuronal cell body;intracellular vesicle;vesicle;melanosome;extracellular matrix;cytoplasmic part;axon part;organelle;cytoplasm;cytoplasmic vesicle;neuron projection;pigment granule;cell projection part;cell part;intracellular organelle;cell;basement membrane;extracellular space;neuron part;axon;intracellular;extracellular vesicle;extracellular exosome;cellular_component;extracellular region;proteinaceous extracellular matrix; 5;5;5;3;4;4;3;3;3;2;2;3;5;4;4;4;7;2;4;4;2;4;5;4;6;3;2;3;2;3;3;3;5;3;3;4;1;2;3; GO:0030414;GO:0098772;GO:0003674;GO:0061135;GO:0004857;GO:0004866;GO:0004867;GO:0030234;GO:0061134; peptidase inhibitor activity;molecular function regulator;molecular_function;endopeptidase regulator activity;enzyme inhibitor activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;enzyme regulator activity;peptidase regulator activity; 5;2;1;5;4;6;7;3;4; K19614 map04310; Wnt signaling pathway; IPR023795;IPR000215;IPR033832;IPR023796; Serpin, conserved site;Serpin family;Pigment epithelium derived factor;Serpin domain; plasma membrane Hs4505709 704.0 V [V] Defense mechanisms; Q8NCS7 Choline transporter-like protein 5 OS=Homo sapiens OX=9606 GN=SLC44A5 PE=2 SV=5 - [CTL5_HUMAN] 1.024 1.141 0.938 0.91 1.156 1.018 0.89745837 0.562697062 0.787197232 0.087042844 0.82208589 0.291567925 0.880622837 0.368769631 GO:0006656;GO:0006650;GO:0044249;GO:0034641;GO:0006807;GO:0044281;GO:0044283;GO:0046486;GO:0044699;GO:1901576;GO:0044710;GO:0044711;GO:0097164;GO:0055085;GO:0071704;GO:0042439;GO:0006644;GO:0006810;GO:0006629;GO:0009308;GO:0045017;GO:0046165;GO:0009987;GO:0044106;GO:0009058;GO:0008150;GO:0008152;GO:0046474;GO:0044255;GO:0051234;GO:0090407;GO:0051179;GO:1902578;GO:0008610;GO:0044238;GO:1901564;GO:0006576;GO:1901566;GO:0008654;GO:0044765;GO:0044237;GO:1901617;GO:0006066;GO:0006796;GO:0006793;GO:0019637;GO:0044763;GO:0046470;GO:1901615; phosphatidylcholine biosynthetic process;glycerophospholipid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;small molecule metabolic process;small molecule biosynthetic process;glycerolipid metabolic process;single-organism process;organic substance biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;ammonium ion metabolic process;transmembrane transport;organic substance metabolic process;ethanolamine-containing compound metabolic process;phospholipid metabolic process;transport;lipid metabolic process;amine metabolic process;glycerolipid biosynthetic process;alcohol biosynthetic process;cellular process;cellular amine metabolic process;biosynthetic process;biological_process;metabolic process;glycerophospholipid biosynthetic process;cellular lipid metabolic process;establishment of localization;organophosphate biosynthetic process;localization;single-organism localization;lipid biosynthetic process;primary metabolic process;organonitrogen compound metabolic process;cellular biogenic amine metabolic process;organonitrogen compound biosynthetic process;phospholipid biosynthetic process;single-organism transport;cellular metabolic process;organic hydroxy compound biosynthetic process;alcohol metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;organophosphate metabolic process;single-organism cellular process;phosphatidylcholine metabolic process;organic hydroxy compound metabolic process; 6;6;4;4;3;4;5;5;2;4;3;4;4;4;3;4;5;4;4;5;5;6;2;5;3;1;2;6;4;3;5;2;3;5;3;4;6;5;5;4;3;5;5;5;4;4;3;5;4; GO:0005886;GO:0031224;GO:0005623;GO:0016021;GO:0016020;GO:0044425;GO:0005575;GO:0044464;GO:0071944; plasma membrane;intrinsic component of membrane;cell;integral component of membrane;membrane;membrane part;cellular_component;cell part;cell periphery; 3;3;2;4;2;2;1;2;3; K15377 map05231; Choline metabolism in cancer; IPR007603; Choline transporter-like; plasma membrane Hs22044836 1206.0 I [I] Lipid transport and metabolism; P36956 Sterol regulatory element-binding protein 1 OS=Homo sapiens OX=9606 GN=SREBF1 PE=1 SV=2 - [SRBP1_HUMAN] 1.029 0.897 1.042 0.931 1.074 1.373 1.147157191 1.25E-13 0.866852886 5.73E-15 1.161649944 1.04E-17 1.27839851 2.11E-14 GO:0033157;GO:0051046;GO:0051048;GO:0051049;GO:0044281;GO:0044283;GO:0051716;GO:1902932;GO:0060541;GO:0032101;GO:0006839;GO:0046486;GO:0046483;GO:0009605;GO:0034284;GO:0019538;GO:0010638;GO:0051253;GO:0009894;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:1903008;GO:0051254;GO:0051223;GO:0051224;GO:0050789;GO:0030072;GO:0030073;GO:0032094;GO:0006886;GO:0071840;GO:1903308;GO:0018130;GO:0070201;GO:0008016;GO:0007623;GO:0006629;GO:1903649;GO:0009306;GO:0006626;GO:0043412;GO:1903522;GO:0009267;GO:0016070;GO:0010557;GO:0010556;GO:0006695;GO:0006694;GO:2001252;GO:0010558;GO:0051128;GO:1903827;GO:0098732;GO:0014074;GO:0014070;GO:0000122;GO:0008286;GO:0035601;GO:0046883;GO:0046888;GO:0046889;GO:0044255;GO:0031647;GO:0060341;GO:0010821;GO:0042594;GO:0045444;GO:0007275;GO:0033993;GO:2000112;GO:2000113;GO:0046683;GO:0032526;GO:0019217;GO:0019216;GO:0019219;GO:0019218;GO:0090311;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0051276;GO:0051173;GO:0048856;GO:0009914;GO:0006066;GO:0048523;GO:0048522;GO:0008104;GO:0032104;GO:0009299;GO:0003013;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0007005;GO:0044712;GO:0044710;GO:0044711;GO:0033036;GO:0045540;GO:0045542;GO:0051051;GO:1902653;GO:1902652;GO:2001141;GO:0010033;GO:0031668;GO:0031669;GO:0031667;GO:0016568;GO:0016569;GO:0070887;GO:0010629;GO:0006807;GO:0044267;GO:0044260;GO:0006366;GO:0009889;GO:0050796;GO:0050794;GO:0051239;GO:0051234;GO:0071375;GO:0050896;GO:1903310;GO:0033044;GO:0032107;GO:0006631;GO:0033043;GO:0006639;GO:0006638;GO:0010565;GO:1903531;GO:1903530;GO:1903533;GO:0044699;GO:0032880;GO:0044057;GO:0051246;GO:0051247;GO:0002027;GO:0031399;GO:0016126;GO:0071398;GO:0016125;GO:0072594;GO:0071396;GO:1903747;GO:0042493;GO:1902680;GO:0033365;GO:0048731;GO:0030323;GO:0030324;GO:0043933;GO:0016236;GO:0046890;GO:0006325;GO:1901654;GO:0010867;GO:0042789;GO:0010866;GO:0016241;GO:0045935;GO:0045934;GO:0010817;GO:0022411;GO:0007267;GO:0042221;GO:0035295;GO:0008610;GO:0009746;GO:0044238;GO:0009743;GO:0002790;GO:0002791;GO:0002792;GO:0044237;GO:0009749;GO:1903214;GO:0045893;GO:0090087;GO:0019222;GO:0032386;GO:0048583;GO:0031056;GO:0031058;GO:1901362;GO:1901360;GO:0048869;GO:0046879;GO:0048511;GO:0048513;GO:0048518;GO:0048519;GO:0006605;GO:0045184;GO:0072655;GO:0043436;GO:0043434;GO:0003008;GO:0044700;GO:0044707;GO:0010243;GO:0033554;GO:1903146;GO:0003015;GO:0043170;GO:0097659;GO:0016575;GO:0016570;GO:0006810;GO:0006950;GO:0050810;GO:0034654;GO:0046903;GO:0044271;GO:0046907;GO:0080134;GO:0031401;GO:0006355;GO:0006357;GO:0006351;GO:1901617;GO:1901615;GO:0090208;GO:0090205;GO:0090207;GO:0030154;GO:0015833;GO:0060047;GO:0046676;GO:1904950;GO:0009719;GO:0006139;GO:0006476;GO:0032270;GO:0032502;GO:0032501;GO:0006641;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0032870;GO:0032879;GO:0016482;GO:0000422;GO:0070542;GO:0051252;GO:0032570;GO:0048545;GO:1902275;GO:0080135;GO:0071229;GO:0045017;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0010506;GO:0061726;GO:0006914;GO:0034613;GO:0023061;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0051649;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0042180;GO:1902589;GO:1901652;GO:1901653;GO:1902582;GO:1902580;GO:0080090;GO:0032774;GO:0010605;GO:0010604;GO:0070727;GO:0010893;GO:0045834;GO:0060255;GO:0032787;GO:0031065;GO:0090276;GO:0051591;GO:0031063;GO:0090278;GO:0070585;GO:0019432;GO:0019438;GO:0090181;GO:0032940;GO:1901576;GO:0050708;GO:0050709;GO:0016043;GO:0065007;GO:1902930;GO:0065008;GO:0051130;GO:0008015;GO:0033762;GO:0036211;GO:0008150;GO:0008152;GO:0003062;GO:1901698;GO:1901699;GO:0044248;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0042886;GO:0046463;GO:0046460;GO:0006996;GO:0046165;GO:0045892;GO:0001101;GO:0008202;GO:0008203;GO:0090312;GO:0032268;GO:0007568;GO:0006082;GO:0009725;GO:0045940;GO:0010628;GO:0045944;GO:0071495;GO:0009991;GO:0031329;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0019752;GO:0090304;GO:0071496;GO:0032869;GO:0032868;GO:0071417;GO:1903508;GO:0010467;GO:0010468;GO:0007154;GO:0015031;GO:0044249; regulation of intracellular protein transport;regulation of secretion;negative regulation of secretion;regulation of transport;small molecule metabolic process;small molecule biosynthetic process;cellular response to stimulus;positive regulation of alcohol biosynthetic process;respiratory system development;regulation of response to external stimulus;mitochondrial transport;glycerolipid metabolic process;heterocycle metabolic process;response to external stimulus;response to monosaccharide;protein metabolic process;positive regulation of organelle organization;negative regulation of RNA metabolic process;regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;organelle disassembly;positive regulation of RNA metabolic process;regulation of protein transport;negative regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;response to food;intracellular protein transport;cellular component organization or biogenesis;regulation of chromatin modification;heterocycle biosynthetic process;regulation of establishment of protein localization;regulation of heart contraction;circadian rhythm;lipid metabolic process;regulation of cytoplasmic transport;protein secretion;protein targeting to mitochondrion;macromolecule modification;regulation of blood circulation;cellular response to starvation;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;cholesterol biosynthetic process;steroid biosynthetic process;positive regulation of chromosome organization;negative regulation of macromolecule biosynthetic process;regulation of cellular component organization;regulation of cellular protein localization;macromolecule deacylation;response to purine-containing compound;response to organic cyclic compound;negative regulation of transcription from RNA polymerase II promoter;insulin receptor signaling pathway;protein deacylation;regulation of hormone secretion;negative regulation of hormone secretion;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;regulation of protein stability;regulation of cellular localization;regulation of mitochondrion organization;response to starvation;fat cell differentiation;multicellular organism development;response to lipid;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;response to organophosphorus;response to retinoic acid;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of steroid metabolic process;regulation of protein deacetylation;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;chromosome organization;positive regulation of nitrogen compound metabolic process;anatomical structure development;hormone transport;alcohol metabolic process;negative regulation of cellular process;positive regulation of cellular process;protein localization;regulation of response to extracellular stimulus;mRNA transcription;circulatory system process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;mitochondrion organization;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;macromolecule localization;regulation of cholesterol biosynthetic process;positive regulation of cholesterol biosynthetic process;negative regulation of transport;secondary alcohol biosynthetic process;secondary alcohol metabolic process;regulation of RNA biosynthetic process;response to organic substance;cellular response to extracellular stimulus;cellular response to nutrient levels;response to nutrient levels;chromatin modification;covalent chromatin modification;cellular response to chemical stimulus;negative regulation of gene expression;nitrogen compound metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of biosynthetic process;regulation of insulin secretion;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;cellular response to peptide hormone stimulus;response to stimulus;positive regulation of chromatin modification;regulation of chromosome organization;regulation of response to nutrient levels;fatty acid metabolic process;regulation of organelle organization;acylglycerol metabolic process;neutral lipid metabolic process;regulation of cellular ketone metabolic process;negative regulation of secretion by cell;regulation of secretion by cell;regulation of protein targeting;single-organism process;regulation of protein localization;regulation of system process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of heart rate;regulation of protein modification process;sterol biosynthetic process;cellular response to fatty acid;sterol metabolic process;establishment of protein localization to organelle;cellular response to lipid;regulation of establishment of protein localization to mitochondrion;response to drug;positive regulation of RNA biosynthetic process;protein localization to organelle;system development;respiratory tube development;lung development;macromolecular complex subunit organization;macroautophagy;regulation of lipid biosynthetic process;chromatin organization;response to ketone;positive regulation of triglyceride biosynthetic process;mRNA transcription from RNA polymerase II promoter;regulation of triglyceride biosynthetic process;regulation of macroautophagy;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;regulation of hormone levels;cellular component disassembly;cell-cell signaling;response to chemical;tube development;lipid biosynthetic process;response to hexose;primary metabolic process;response to carbohydrate;peptide secretion;regulation of peptide secretion;negative regulation of peptide secretion;cellular metabolic process;response to glucose;regulation of protein targeting to mitochondrion;positive regulation of transcription, DNA-templated;regulation of peptide transport;regulation of metabolic process;regulation of intracellular transport;regulation of response to stimulus;regulation of histone modification;positive regulation of histone modification;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular developmental process;hormone secretion;rhythmic process;animal organ development;positive regulation of biological process;negative regulation of biological process;protein targeting;establishment of protein localization;establishment of protein localization to mitochondrion;oxoacid metabolic process;response to peptide hormone;system process;single organism signaling;single-multicellular organism process;response to organonitrogen compound;cellular response to stress;regulation of mitophagy;heart process;macromolecule metabolic process;nucleic acid-templated transcription;histone deacetylation;histone modification;transport;response to stress;regulation of steroid biosynthetic process;nucleobase-containing compound biosynthetic process;secretion;cellular nitrogen compound biosynthetic process;intracellular transport;regulation of response to stress;positive regulation of protein modification process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;positive regulation of triglyceride metabolic process;positive regulation of cholesterol metabolic process;regulation of triglyceride metabolic process;cell differentiation;peptide transport;heart contraction;negative regulation of insulin secretion;negative regulation of establishment of protein localization;response to endogenous stimulus;nucleobase-containing compound metabolic process;protein deacetylation;positive regulation of cellular protein metabolic process;developmental process;multicellular organismal process;triglyceride metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to hormone stimulus;regulation of localization;cytosolic transport;mitophagy;response to fatty acid;regulation of RNA metabolic process;response to progesterone;response to steroid hormone;regulation of chromatin organization;regulation of cellular response to stress;cellular response to acid chemical;glycerolipid biosynthetic process;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;regulation of autophagy;mitochondrion disassembly;autophagy;cellular protein localization;signal release;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;catabolic process;localization;single-organism localization;cellular localization;cellular ketone metabolic process;single-organism organelle organization;response to peptide;cellular response to peptide;single-organism intracellular transport;single-organism cellular localization;regulation of primary metabolic process;RNA biosynthetic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;positive regulation of steroid biosynthetic process;positive regulation of lipid metabolic process;regulation of macromolecule metabolic process;monocarboxylic acid metabolic process;positive regulation of histone deacetylation;regulation of peptide hormone secretion;response to cAMP;regulation of histone deacetylation;negative regulation of peptide hormone secretion;protein localization to mitochondrion;triglyceride biosynthetic process;aromatic compound biosynthetic process;regulation of cholesterol metabolic process;secretion by cell;organic substance biosynthetic process;regulation of protein secretion;negative regulation of protein secretion;cellular component organization;biological regulation;regulation of alcohol biosynthetic process;regulation of biological quality;positive regulation of cellular component organization;blood circulation;response to glucagon;protein modification process;biological_process;metabolic process;regulation of heart rate by chemical signal;response to nitrogen compound;cellular response to nitrogen compound;cellular catabolic process;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;amide transport;acylglycerol biosynthetic process;neutral lipid biosynthetic process;organelle organization;alcohol biosynthetic process;negative regulation of transcription, DNA-templated;response to acid chemical;steroid metabolic process;cholesterol metabolic process;positive regulation of protein deacetylation;regulation of cellular protein metabolic process;aging;organic acid metabolic process;response to hormone;positive regulation of steroid metabolic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;cellular response to endogenous stimulus;response to extracellular stimulus;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;nucleic acid metabolic process;cellular response to external stimulus;cellular response to insulin stimulus;response to insulin;cellular response to organonitrogen compound;positive regulation of nucleic acid-templated transcription;gene expression;regulation of gene expression;cell communication;protein transport;cellular biosynthetic process; 6;5;4;4;4;5;3;5;5;4;6;5;4;3;6;4;5;5;4;3;3;4;4;5;5;5;4;2;7;6;4;6;2;7;5;5;6;3;4;6;5;5;5;5;5;5;5;5;8;6;6;5;4;5;6;5;5;7;8;7;4;4;5;4;4;4;6;4;6;4;5;6;6;5;5;6;5;5;6;7;6;3;4;3;4;5;5;4;3;5;5;3;3;4;5;7;4;4;5;6;7;5;4;3;4;3;6;6;3;7;6;6;4;4;5;5;6;7;4;5;3;5;4;7;4;6;3;3;3;6;2;7;6;6;5;5;6;5;5;4;5;7;2;4;4;5;5;4;6;7;6;6;5;6;6;4;6;6;4;4;4;4;4;5;5;5;6;8;6;5;5;5;4;4;4;3;4;5;7;3;5;6;6;5;3;8;6;6;5;3;5;3;5;5;5;4;4;6;2;4;2;2;6;4;6;5;5;3;3;3;4;4;5;5;4;7;5;4;4;3;6;5;5;5;5;4;6;6;7;6;5;4;5;6;5;5;6;6;6;3;3;4;8;5;2;2;7;2;4;7;7;5;3;6;4;5;5;6;5;6;4;5;5;5;3;5;5;4;6;3;5;5;6;3;5;4;4;4;3;2;3;3;4;4;5;6;5;4;4;6;4;4;4;6;4;4;7;6;5;5;6;5;7;7;5;7;4;4;6;5;3;2;5;3;4;5;6;5;1;2;5;4;5;4;3;4;2;4;5;3;4;5;6;5;4;6;6;4;5;7;7;5;4;4;4;5;5;7;4;4;5;5;5;5;4;4;4;6;5;4;7;6;5;7;5;5;4;5;4; GO:0031975;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0005654;GO:0042175;GO:0044464;GO:0070013;GO:0016023;GO:0016021;GO:0016020;GO:0098588;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044433;GO:0044432;GO:0044431;GO:0031090;GO:0030662;GO:0005783;GO:0031974;GO:0005789;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0012506;GO:0012507;GO:0031982;GO:0044446;GO:0044444;GO:0005634;GO:0005635;GO:0030658;GO:0030659;GO:0098805;GO:0031981;GO:0031988;GO:0005794;GO:0031967;GO:0031224;GO:0005737;GO:0097708;GO:0000139;GO:0031410;GO:0005623;GO:0005622;GO:0030133;GO:0030135;GO:0030134;GO:0032991;GO:0005575; envelope;nuclear part;intracellular part;membrane part;organelle part;nucleoplasm;nuclear outer membrane-endoplasmic reticulum membrane network;cell part;intracellular organelle lumen;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;bounding membrane of organelle;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;cytoplasmic vesicle part;endoplasmic reticulum part;Golgi apparatus part;organelle membrane;coated vesicle membrane;endoplasmic reticulum;membrane-enclosed lumen;endoplasmic reticulum membrane;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;vesicle membrane;ER to Golgi transport vesicle membrane;vesicle;intracellular organelle part;cytoplasmic part;nucleus;nuclear envelope;transport vesicle membrane;cytoplasmic vesicle membrane;whole membrane;nuclear lumen;membrane-bounded vesicle;Golgi apparatus;organelle envelope;intrinsic component of membrane;cytoplasm;intracellular vesicle;Golgi membrane;cytoplasmic vesicle;cell;intracellular;transport vesicle;coated vesicle;ER to Golgi transport vesicle;macromolecular complex;cellular_component; 3;4;3;2;2;5;3;2;4;5;4;2;4;3;4;3;5;4;4;4;3;4;4;2;3;3;3;2;3;4;5;4;3;4;5;4;4;5;3;5;5;4;4;3;4;4;5;5;2;3;4;6;5;2;1; GO:0001067;GO:0044212;GO:0005488;GO:0000975;GO:0000978;GO:0043565;GO:0001012;GO:0001159;GO:0032810;GO:1901363;GO:0003674;GO:0003676;GO:0003677;GO:0097159;GO:1990837;GO:0003690;GO:0001228;GO:0000976;GO:0000977;GO:0001077;GO:0001071;GO:0044877;GO:0000987;GO:0000982;GO:0000981;GO:0003700;GO:0003682; regulatory region nucleic acid binding;transcription regulatory region DNA binding;binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;sequence-specific DNA binding;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;sterol response element binding;heterocyclic compound binding;molecular_function;nucleic acid binding;DNA binding;organic cyclic compound binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;transcription regulatory region sequence-specific DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;nucleic acid binding transcription factor activity;macromolecular complex binding;core promoter proximal region sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding;chromatin binding; 5;7;2;6;10;6;8;8;8;3;1;4;5;3;7;6;5;8;9;6;2;3;9;5;4;3;4; K07197 map04152;map04910;map04931;map04932; AMPK signaling pathway;Insulin signaling pathway;Insulin resistance;Non-alcoholic fatty liver disease (NAFLD); IPR011598; Myc-type, basic helix-loop-helix (bHLH) domain; nucleus Hs7242207 2288.0 K [K] Transcription; Q8N5R6 Coiled-coil domain-containing protein 33 OS=Homo sapiens OX=9606 GN=CCDC33 PE=1 SV=3 - [CCD33_HUMAN] 1.358 0.936 0.873 1.071 0.992 0.901 1.450854701 nan 1.079637097 nan 0.932692308 nan 0.908266129 nan IPR000008; C2 domain; cytosol Q8IVV2 Lipoxygenase homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LOXHD1 PE=2 SV=4 - [LOXH1_HUMAN] 1.009 0.892 1.317 1.011 0.942 1.191 1.131165919 0.564256679 1.073248408 0.906967726 1.476457399 0.652029835 1.26433121 0.064616503 GO:0032501;GO:0007605;GO:0050954;GO:0007600;GO:0008150;GO:0050877;GO:0003008; multicellular organismal process;sensory perception of sound;sensory perception of mechanical stimulus;sensory perception;biological_process;neurological system process;system process; 2;7;6;5;1;4;3; GO:0032421;GO:0032420;GO:0042995;GO:0044464;GO:0005623;GO:0005575;GO:0097458;GO:0098858;GO:0098862;GO:0043226;GO:0044422; stereocilium bundle;stereocilium;cell projection;cell part;cell;cellular_component;neuron part;actin-based cell projection;cluster of actin-based cell projections;organelle;organelle part; 4;3;3;2;2;1;3;4;3;2;2; IPR001024; PLAT/LH2 domain; cytosol 310826027 134.0 NW [N] Cell motility; [W] Extracellular structures; COG3170 Tfp pilus assembly protein FimV Q7Z5N4 Protein sidekick-1 OS=Homo sapiens OX=9606 GN=SDK1 PE=2 SV=3 - [SDK1_HUMAN] 0.976 0.865 1.066 1.089 1.109 1.305 1.128323699 nan 0.981965735 nan 1.232369942 nan 1.176735798 nan GO:0048468;GO:0016358;GO:0007610;GO:0031344;GO:0071840;GO:0048869;GO:0045664;GO:0060998;GO:0048513;GO:0060996;GO:0007155;GO:0010975;GO:0010033;GO:0098742;GO:0044707;GO:0044708;GO:0010243;GO:0003407;GO:0022607;GO:0031175;GO:0016043;GO:0098609;GO:0065007;GO:0007416;GO:0048646;GO:0009887;GO:0050793;GO:0009888;GO:0050794;GO:0008150;GO:0051239;GO:0007423;GO:0050896;GO:0051960;GO:0043010;GO:0050808;GO:0048148;GO:0030154;GO:0051128;GO:0010842;GO:0060041;GO:0060042;GO:0009653;GO:0014070;GO:0009719;GO:0050767;GO:0007156;GO:0060284;GO:0022610;GO:0032502;GO:0032501;GO:0009987;GO:0045595;GO:0001654;GO:0043279;GO:0044699;GO:0050773;GO:0048731;GO:1901698;GO:0030030;GO:0007275;GO:0050789;GO:0044085;GO:0048729;GO:0090596;GO:0048666;GO:0030182;GO:0048592;GO:0048593;GO:0044767;GO:0044763;GO:0042220;GO:0042221;GO:0022008;GO:1901700;GO:0030534;GO:0048699;GO:0007399;GO:0048856;GO:2000026; cell development;dendrite development;behavior;regulation of cell projection organization;cellular component organization or biogenesis;cellular developmental process;regulation of neuron differentiation;regulation of dendritic spine development;animal organ development;dendritic spine development;cell adhesion;regulation of neuron projection development;response to organic substance;cell-cell adhesion via plasma-membrane adhesion molecules;single-multicellular organism process;single-organism behavior;response to organonitrogen compound;neural retina development;cellular component assembly;neuron projection development;cellular component organization;cell-cell adhesion;biological regulation;synapse assembly;anatomical structure formation involved in morphogenesis;organ morphogenesis;regulation of developmental process;tissue development;regulation of cellular process;biological_process;regulation of multicellular organismal process;sensory organ development;response to stimulus;regulation of nervous system development;camera-type eye development;synapse organization;behavioral response to cocaine;cell differentiation;regulation of cellular component organization;retina layer formation;retina development in camera-type eye;retina morphogenesis in camera-type eye;anatomical structure morphogenesis;response to organic cyclic compound;response to endogenous stimulus;regulation of neurogenesis;homophilic cell adhesion via plasma membrane adhesion molecules;regulation of cell development;biological adhesion;developmental process;multicellular organismal process;cellular process;regulation of cell differentiation;eye development;response to alkaloid;single-organism process;regulation of dendrite development;system development;response to nitrogen compound;cell projection organization;multicellular organism development;regulation of biological process;cellular component biogenesis;tissue morphogenesis;sensory organ morphogenesis;neuron development;neuron differentiation;eye morphogenesis;camera-type eye morphogenesis;single-organism developmental process;single-organism cellular process;response to cocaine;response to chemical;neurogenesis;response to oxygen-containing compound;adult behavior;generation of neurons;nervous system development;anatomical structure development;regulation of multicellular organismal development; 4;4;2;5;2;4;7;5;4;4;3;6;4;5;3;3;4;4;4;5;3;4;2;5;3;4;3;4;3;1;3;4;2;5;6;4;5;5;4;4;4;5;3;5;3;6;6;5;2;2;2;2;4;5;5;2;5;4;4;4;4;2;3;4;5;5;6;6;7;3;3;5;3;6;4;4;7;5;3;4; GO:0031224;GO:0031982;GO:0016021;GO:0016020;GO:0030054;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0043226;GO:0044464;GO:0005623;GO:0071944;GO:0045202;GO:0070062;GO:0005886;GO:1903561;GO:0005575;GO:0005576; intrinsic component of membrane;vesicle;integral component of membrane;membrane;cell junction;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;organelle;cell part;cell;cell periphery;synapse;extracellular exosome;plasma membrane;extracellular vesicle;cellular_component;extracellular region; 3;4;4;2;2;3;2;2;3;2;2;2;3;2;4;3;3;1;2; GO:0003674;GO:0005488;GO:0042802;GO:0005515; molecular_function;binding;identical protein binding;protein binding; 1;2;4;3; K16353 IPR003599;IPR003598;IPR013783;IPR013098;IPR007110;IPR003961; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;Immunoglobulin I-set;Immunoglobulin-like domain;Fibronectin type III; cytosol Hs20540124 2987.0 T [T] Signal transduction mechanisms; Q96KB5 Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3 - [TOPK_HUMAN] 1.108 0.885 1.178 1.155 0.953 0.627 1.251977401 nan 1.211962225 nan 1.331073446 nan 0.65792235 nan GO:0019220;GO:0080090;GO:0019222;GO:0032435;GO:0048585;GO:0048583;GO:0031348;GO:0044710;GO:0000280;GO:0007165;GO:0071482;GO:0031347;GO:0050728;GO:0010605;GO:0032434;GO:0009968;GO:0009966;GO:0071840;GO:0000165;GO:0050727;GO:1901799;GO:0009314;GO:0048519;GO:0060255;GO:0030162;GO:0030163;GO:0042325;GO:0044700;GO:0042326;GO:0009605;GO:0019538;GO:0009411;GO:0033554;GO:0009416;GO:0009894;GO:0009895;GO:0009892;GO:0034644;GO:0035556;GO:0043170;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0045936;GO:0016043;GO:0065007;GO:0023014;GO:0071214;GO:0007049;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0008150;GO:0006954;GO:1902532;GO:0031400;GO:1902531;GO:0051603;GO:0050896;GO:0080135;GO:0010498;GO:0043412;GO:0006511;GO:0032102;GO:0008152;GO:0032101;GO:0016310;GO:0009611;GO:0044248;GO:0023057;GO:0042176;GO:0042177;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0044699;GO:0043408;GO:0051248;GO:0071478;GO:0043161;GO:0010563;GO:0051246;GO:0031098;GO:0031399;GO:0006508;GO:1903034;GO:1903035;GO:0009628;GO:0031330;GO:0070303;GO:1903050;GO:0009987;GO:0019941;GO:0032872;GO:0032873;GO:0044257;GO:0032269;GO:0032268;GO:0045861;GO:0080134;GO:0031329;GO:0031324;GO:0031323;GO:1903047;GO:0022402;GO:0043632;GO:0007067;GO:1902589;GO:0071704;GO:0006468;GO:1903051;GO:0000278;GO:1903362;GO:1903363;GO:0061136;GO:0006464;GO:0051174;GO:0051403;GO:0044763;GO:0070302;GO:0007154;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0043409;GO:0044237;GO:0006796;GO:0048285;GO:0006793;GO:0001933;GO:0001932;GO:0048523; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of response to stimulus;regulation of response to stimulus;negative regulation of defense response;single-organism metabolic process;nuclear division;signal transduction;cellular response to light stimulus;regulation of defense response;negative regulation of inflammatory response;negative regulation of macromolecule metabolic process;regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;regulation of inflammatory response;negative regulation of proteasomal protein catabolic process;response to radiation;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;response to external stimulus;protein metabolic process;response to UV;cellular response to stress;response to light stimulus;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;cellular response to UV;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;negative regulation of phosphate metabolic process;cellular component organization;biological regulation;signal transduction by protein phosphorylation;cellular response to abiotic stimulus;cell cycle;cellular response to stimulus;regulation of cellular process;defense response;response to stress;protein modification process;biological_process;inflammatory response;negative regulation of intracellular signal transduction;negative regulation of protein modification process;regulation of intracellular signal transduction;proteolysis involved in cellular protein catabolic process;response to stimulus;regulation of cellular response to stress;proteasomal protein catabolic process;macromolecule modification;ubiquitin-dependent protein catabolic process;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;phosphorylation;response to wounding;cellular catabolic process;negative regulation of signaling;regulation of protein catabolic process;negative regulation of protein catabolic process;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;single-organism process;regulation of MAPK cascade;negative regulation of protein metabolic process;cellular response to radiation;proteasome-mediated ubiquitin-dependent protein catabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;regulation of protein modification process;proteolysis;regulation of response to wounding;negative regulation of response to wounding;response to abiotic stimulus;negative regulation of cellular catabolic process;negative regulation of stress-activated protein kinase signaling cascade;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;regulation of stress-activated MAPK cascade;negative regulation of stress-activated MAPK cascade;cellular protein catabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;negative regulation of proteolysis;regulation of response to stress;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle process;modification-dependent macromolecule catabolic process;mitotic nuclear division;single-organism organelle organization;organic substance metabolic process;protein phosphorylation;negative regulation of proteolysis involved in cellular protein catabolic process;mitotic cell cycle;regulation of cellular protein catabolic process;negative regulation of cellular protein catabolic process;regulation of proteasomal protein catabolic process;cellular protein modification process;regulation of phosphorus metabolic process;stress-activated MAPK cascade;single-organism cellular process;regulation of stress-activated protein kinase signaling cascade;cell communication;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;negative regulation of MAPK cascade;cellular metabolic process;phosphate-containing compound metabolic process;organelle fission;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process; 6;4;3;8;3;3;4;3;6;4;6;5;5;4;8;4;4;2;5;5;7;4;2;4;6;5;7;3;7;3;4;6;4;5;4;4;3;7;5;4;2;5;4;5;4;6;3;2;4;4;4;3;3;4;3;5;1;5;5;6;5;6;2;4;6;5;8;4;2;4;6;4;4;3;5;5;2;4;3;4;2;6;5;5;7;5;5;5;6;5;5;4;3;5;6;7;2;7;6;7;6;5;5;6;4;5;4;4;5;4;6;5;4;3;7;7;5;6;6;7;6;5;6;3;5;4;3;5;4;3;6;3;5;5;4;7;7;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:1901363;GO:0004674;GO:0000166;GO:0016740;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0036094;GO:0043167;GO:0030554;GO:0097159;GO:0001883;GO:0001882;GO:0004672; heterocyclic compound binding;protein serine/threonine kinase activity;nucleotide binding;transferase activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;small molecule binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;protein kinase activity; 3;7;4;3;3;1;2;4;5;5;6;5;2;5;4;6;5;6;4;5;4;3;3;6;3;5;4;6; K08865 IPR034368;IPR008271;IPR011009;IPR000719; Lymphokine-activated killer T-cell-originated protein kinase;Serine/threonine-protein kinase, active site;Protein kinase-like domain;Protein kinase domain; cytosol Hs18490991 669.0 T [T] Signal transduction mechanisms; Q15646 2'-5'-oligoadenylate synthase-like protein OS=Homo sapiens OX=9606 GN=OASL PE=1 SV=2 - [OASL_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0019221;GO:0007165;GO:0007166;GO:0051716;GO:0009615;GO:0044419;GO:0019058;GO:0048519;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0009607;GO:0009605;GO:0002376;GO:0050789;GO:0071357;GO:0065007;GO:0034097;GO:0050792;GO:0050794;GO:0006952;GO:0043903;GO:0006950;GO:0043901;GO:0008150;GO:0006955;GO:0043207;GO:0071345;GO:0050896;GO:0071346;GO:0043900;GO:0023052;GO:0070887;GO:0007154;GO:0044699;GO:1903900;GO:1903901;GO:0045071;GO:0019079;GO:0009987;GO:0098542;GO:0051607;GO:0045069;GO:0071310;GO:0045087;GO:0034340;GO:0034341;GO:0060333;GO:0044764;GO:0044763;GO:0060337;GO:0042221;GO:0016032;GO:0002252;GO:0048525;GO:0044403;GO:0048523; cytokine-mediated signaling pathway;signal transduction;cell surface receptor signaling pathway;cellular response to stimulus;response to virus;interspecies interaction between organisms;viral life cycle;negative regulation of biological process;response to other organism;response to organic substance;multi-organism process;single organism signaling;response to biotic stimulus;response to external stimulus;immune system process;regulation of biological process;cellular response to type I interferon;biological regulation;response to cytokine;regulation of viral process;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;response to stress;negative regulation of multi-organism process;biological_process;immune response;response to external biotic stimulus;cellular response to cytokine stimulus;response to stimulus;cellular response to interferon-gamma;regulation of multi-organism process;signaling;cellular response to chemical stimulus;cell communication;single-organism process;regulation of viral life cycle;negative regulation of viral life cycle;negative regulation of viral genome replication;viral genome replication;cellular process;defense response to other organism;defense response to virus;regulation of viral genome replication;cellular response to organic substance;innate immune response;response to type I interferon;response to interferon-gamma;interferon-gamma-mediated signaling pathway;multi-organism cellular process;single-organism cellular process;type I interferon signaling pathway;response to chemical;viral process;immune effector process;negative regulation of viral process;symbiosis, encompassing mutualism through parasitism;negative regulation of cellular process; 6;4;5;3;4;3;5;2;3;4;2;3;3;3;2;2;6;2;5;4;3;4;4;3;3;1;3;4;6;2;6;3;2;4;4;2;5;5;6;5;2;4;4;6;5;4;5;5;7;3;3;7;3;4;3;4;4;3; GO:0031974;GO:0031981;GO:0016020;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0043228;GO:0043227;GO:0044446;GO:0044444;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;intracellular organelle part;cytoplasmic part;cytoplasm;nucleolus;nucleus;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 2;5;2;4;3;5;4;3;2;4;3;3;3;3;4;4;5;5;2;2;3;2;1;4; GO:1901363;GO:0000166;GO:0016740;GO:0046966;GO:0097367;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0035257;GO:0003824;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0008134;GO:0051427;GO:0030554;GO:0003725;GO:0003723;GO:0005515;GO:0005102;GO:0001883;GO:0001882;GO:0044822;GO:0036094; heterocyclic compound binding;nucleotide binding;transferase activity;thyroid hormone receptor binding;carbohydrate derivative binding;molecular_function;binding;nucleic acid binding;DNA binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;nuclear hormone receptor binding;catalytic activity;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;transcription factor binding;hormone receptor binding;adenyl nucleotide binding;double-stranded RNA binding;RNA binding;protein binding;receptor binding;purine nucleoside binding;nucleoside binding;poly(A) RNA binding;small molecule binding; 3;4;3;5;3;1;2;4;5;4;5;5;6;4;6;2;3;6;5;6;4;5;3;4;5;6;6;5;3;4;5;4;6;3; K14608 IPR029071;IPR000626;IPR018952;IPR026774;IPR006116;IPR006117; Ubiquitin-related domain;Ubiquitin domain;2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal;2'-5'-oligoadenylate synthase;2-5-oligoadenylate synthetase, N-terminal;2-5-oligoadenylate synthetase, conserved site; cytosol 284044814 53.9 O [O] Posttranslational modification, protein turnover, chaperones; COG5272 Ubiquitin Q7LC44 Activity-regulated cytoskeleton-associated protein OS=Homo sapiens OX=9606 GN=ARC PE=1 SV=1 - [ARC_HUMAN] 0.6 0.993 1.477 0.754 1.304 0.268 0.604229607 0.196827833 0.578220859 0.242672792 1.487411883 0.404111385 0.205521472 0.092193708 GO:0050804;GO:0051049;GO:0048584;GO:0007612;GO:0007611;GO:0007165;GO:0007166;GO:0034764;GO:0034765;GO:0032989;GO:0071840;GO:0051716;GO:0048869;GO:0044093;GO:0048518;GO:0003008;GO:0051050;GO:0048583;GO:0023052;GO:1900449;GO:0016192;GO:0044700;GO:0065008;GO:0044707;GO:0048870;GO:0044708;GO:0098916;GO:0099601;GO:0022604;GO:0032411;GO:0032412;GO:0022603;GO:0003002;GO:0006928;GO:1900451;GO:0034767;GO:0000902;GO:0010646;GO:0016043;GO:0065007;GO:0034762;GO:2000311;GO:0065009;GO:0016477;GO:2000273;GO:0050793;GO:0006811;GO:0006810;GO:0009888;GO:0050794;GO:0008150;GO:0051234;GO:0006897;GO:0009952;GO:0022898;GO:0050896;GO:0050890;GO:0009966;GO:0009967;GO:0099536;GO:0032414;GO:0007492;GO:0050803;GO:0007268;GO:0050806;GO:0051128;GO:0023056;GO:0023051;GO:0010647;GO:0009653;GO:0044699;GO:0032409;GO:0032502;GO:0040011;GO:0032501;GO:0050877;GO:0009987;GO:0043270;GO:2000969;GO:0032879;GO:0055085;GO:0048167;GO:0051674;GO:0007610;GO:0007275;GO:0043269;GO:0007389;GO:0007215;GO:0050789;GO:0010469;GO:0048168;GO:0044767;GO:0034220;GO:0044765;GO:0044763;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0006996;GO:0007010;GO:0048856;GO:0099537;GO:0048522; modulation of synaptic transmission;regulation of transport;positive regulation of response to stimulus;learning;learning or memory;signal transduction;cell surface receptor signaling pathway;positive regulation of transmembrane transport;regulation of ion transmembrane transport;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;positive regulation of molecular function;positive regulation of biological process;system process;positive regulation of transport;regulation of response to stimulus;signaling;regulation of glutamate receptor signaling pathway;vesicle-mediated transport;single organism signaling;regulation of biological quality;single-multicellular organism process;cell motility;single-organism behavior;anterograde trans-synaptic signaling;regulation of neurotransmitter receptor activity;regulation of cell morphogenesis;positive regulation of transporter activity;regulation of ion transmembrane transporter activity;regulation of anatomical structure morphogenesis;regionalization;movement of cell or subcellular component;positive regulation of glutamate receptor signaling pathway;positive regulation of ion transmembrane transport;cell morphogenesis;regulation of cell communication;cellular component organization;biological regulation;regulation of transmembrane transport;regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;regulation of molecular function;cell migration;positive regulation of receptor activity;regulation of developmental process;ion transport;transport;tissue development;regulation of cellular process;biological_process;establishment of localization;endocytosis;anterior/posterior pattern specification;regulation of transmembrane transporter activity;response to stimulus;cognition;regulation of signal transduction;positive regulation of signal transduction;synaptic signaling;positive regulation of ion transmembrane transporter activity;endoderm development;regulation of synapse structure or activity;synaptic transmission;positive regulation of synaptic transmission;regulation of cellular component organization;positive regulation of signaling;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;regulation of transporter activity;developmental process;locomotion;multicellular organismal process;neurological system process;cellular process;positive regulation of ion transport;positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;regulation of localization;transmembrane transport;regulation of synaptic plasticity;localization of cell;behavior;multicellular organism development;regulation of ion transport;pattern specification process;glutamate receptor signaling pathway;regulation of biological process;regulation of receptor activity;regulation of neuronal synaptic plasticity;single-organism developmental process;ion transmembrane transport;single-organism transport;single-organism cellular process;cell-cell signaling;cell communication;localization;single-organism localization;organelle organization;cytoskeleton organization;anatomical structure development;trans-synaptic signaling;positive regulation of cellular process; 4;4;3;5;4;4;5;4;5;4;2;3;4;4;2;3;3;3;2;5;5;3;3;3;3;3;7;5;5;4;6;4;5;4;5;5;5;4;3;2;4;6;3;4;5;3;5;4;4;3;1;3;6;6;5;2;5;4;4;5;5;5;4;8;4;4;3;3;4;3;2;4;2;2;2;4;2;4;5;3;4;5;3;2;4;5;4;6;2;4;6;3;5;4;3;4;4;2;3;4;5;3;6;3; GO:0030425;GO:0097060;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0099503;GO:0098589;GO:0036477;GO:0042995;GO:0043231;GO:0030054;GO:0044424;GO:0044425;GO:0098590;GO:0043232;GO:0043229;GO:0043228;GO:0005773;GO:0043227;GO:0043226;GO:0005856;GO:0030141;GO:0097708;GO:0060076;GO:0044444;GO:0012505;GO:0001669;GO:0005737;GO:0031410;GO:0097223;GO:0044456;GO:0043005;GO:0044459;GO:0045211;GO:0014069;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0099572;GO:0071944;GO:0045202;GO:0098805;GO:0044309;GO:0097458;GO:0005886;GO:0043197;GO:0005575;GO:0098794;GO:0005768; dendrite;synaptic membrane;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;secretory vesicle;membrane region;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;cell junction;intracellular part;membrane part;plasma membrane region;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;vacuole;membrane-bounded organelle;organelle;cytoskeleton;secretory granule;intracellular vesicle;excitatory synapse;cytoplasmic part;endomembrane system;acrosomal vesicle;cytoplasm;cytoplasmic vesicle;sperm part;synapse part;neuron projection;plasma membrane part;postsynaptic membrane;postsynaptic density;cell projection part;cell part;cell;intracellular;actin cytoskeleton;postsynaptic specialization;cell periphery;synapse;whole membrane;neuron spine;neuron part;plasma membrane;dendritic spine;cellular_component;postsynapse;endosome; 5;3;4;5;2;5;6;3;4;3;4;2;3;2;4;4;3;3;5;3;2;5;4;4;3;4;3;4;4;5;3;2;4;3;4;4;3;2;2;3;6;3;3;2;3;5;3;3;4;1;3;4; K15867 map05031; Amphetamine addiction; IPR023263; Activity-regulated cytoskeleton-associated protein; cytosol, nucleus P55290 Cadherin-13 OS=Homo sapiens OX=9606 GN=CDH13 PE=1 SV=1 - [CAD13_HUMAN] 0.83 1.051 1.023 0.931 1.135 1.767 0.789724072 nan 0.820264317 nan 0.973358706 nan 1.556828194 nan GO:0044238;GO:0080090;GO:0051234;GO:0050679;GO:0051049;GO:0001667;GO:0048584;GO:0048583;GO:0050848;GO:0007160;GO:0007162;GO:0050927;GO:0050920;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:1901362;GO:0071840;GO:0051716;GO:0042330;GO:0045785;GO:0009966;GO:0009967;GO:0010467;GO:0090132;GO:0071704;GO:0048514;GO:0048518;GO:0048519;GO:0016192;GO:0051254;GO:0042127;GO:0006935;GO:0019722;GO:0060255;GO:0051252;GO:0048659;GO:0007173;GO:2001141;GO:0051668;GO:0010033;GO:0098742;GO:0010631;GO:0044700;GO:0044707;GO:0009605;GO:0035556;GO:0010556;GO:0048870;GO:0050926;GO:0046483;GO:0007154;GO:0072358;GO:0050921;GO:0022607;GO:0034645;GO:0009891;GO:0071402;GO:0006928;GO:0008284;GO:0051674;GO:0019932;GO:1901184;GO:0050789;GO:0097659;GO:0043542;GO:1901576;GO:0009653;GO:0016601;GO:0001568;GO:0007266;GO:0033002;GO:0016043;GO:0043616;GO:0019219;GO:0065007;GO:0045893;GO:0006366;GO:0016477;GO:0002040;GO:0048646;GO:0018130;GO:0006810;GO:0006139;GO:0098609;GO:0044260;GO:0009889;GO:0050794;GO:0050918;GO:0008150;GO:0008152;GO:0019438;GO:0034654;GO:1902533;GO:1902531;GO:0010604;GO:0016070;GO:0006897;GO:0050896;GO:0019222;GO:0006355;GO:0006357;GO:2000145;GO:0006351;GO:2000147;GO:0072359;GO:0032103;GO:0032101;GO:0030155;GO:0051173;GO:0031326;GO:0051128;GO:0023056;GO:0034641;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0009719;GO:0007156;GO:0001944;GO:0050673;GO:0030031;GO:0022610;GO:0030032;GO:0071495;GO:0008285;GO:0032501;GO:0055098;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0060627;GO:0051270;GO:0045216;GO:0044271;GO:0032879;GO:0009893;GO:0090130;GO:0007049;GO:0050678;GO:0071404;GO:0001954;GO:0001952;GO:1902680;GO:0006807;GO:0045944;GO:0048731;GO:1901360;GO:0032502;GO:0048856;GO:0032774;GO:0031328;GO:0030030;GO:0034332;GO:0016339;GO:0034330;GO:0031323;GO:0031589;GO:0042058;GO:0090304;GO:0043170;GO:0044237;GO:0055096;GO:0055095;GO:0055094;GO:0010628;GO:0001525;GO:2000112;GO:0010557;GO:0007275;GO:1903508;GO:0071310;GO:0044085;GO:0034329;GO:0010468;GO:0050850;GO:0030335;GO:0030334;GO:0045935;GO:0000278;GO:0048660;GO:0048661;GO:0010810;GO:0010811;GO:0044249;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0097581;GO:0007155;GO:0042221;GO:0007265;GO:0007264;GO:0030100;GO:0051179;GO:0051641;GO:0040011;GO:0051272;GO:0040012;GO:0040017;GO:0031325;GO:0001938;GO:0001936;GO:0001935;GO:0048523;GO:0048522; primary metabolic process;regulation of primary metabolic process;establishment of localization;positive regulation of epithelial cell proliferation;regulation of transport;ameboidal-type cell migration;positive regulation of response to stimulus;regulation of response to stimulus;regulation of calcium-mediated signaling;cell-matrix adhesion;negative regulation of cell adhesion;positive regulation of positive chemotaxis;regulation of chemotaxis;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;taxis;positive regulation of cell adhesion;regulation of signal transduction;positive regulation of signal transduction;gene expression;epithelium migration;organic substance metabolic process;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;vesicle-mediated transport;positive regulation of RNA metabolic process;regulation of cell proliferation;chemotaxis;calcium-mediated signaling;regulation of macromolecule metabolic process;regulation of RNA metabolic process;smooth muscle cell proliferation;epidermal growth factor receptor signaling pathway;regulation of RNA biosynthetic process;localization within membrane;response to organic substance;cell-cell adhesion via plasma-membrane adhesion molecules;epithelial cell migration;single organism signaling;single-multicellular organism process;response to external stimulus;intracellular signal transduction;regulation of macromolecule biosynthetic process;cell motility;regulation of positive chemotaxis;heterocycle metabolic process;cell communication;cardiovascular system development;positive regulation of chemotaxis;cellular component assembly;cellular macromolecule biosynthetic process;positive regulation of biosynthetic process;cellular response to lipoprotein particle stimulus;movement of cell or subcellular component;positive regulation of cell proliferation;localization of cell;second-messenger-mediated signaling;regulation of ERBB signaling pathway;regulation of biological process;nucleic acid-templated transcription;endothelial cell migration;organic substance biosynthetic process;anatomical structure morphogenesis;Rac protein signal transduction;blood vessel development;Rho protein signal transduction;muscle cell proliferation;cellular component organization;keratinocyte proliferation;regulation of nucleobase-containing compound metabolic process;biological regulation;positive regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter;cell migration;sprouting angiogenesis;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;transport;nucleobase-containing compound metabolic process;cell-cell adhesion;cellular macromolecule metabolic process;regulation of biosynthetic process;regulation of cellular process;positive chemotaxis;biological_process;metabolic process;aromatic compound biosynthetic process;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;positive regulation of macromolecule metabolic process;RNA metabolic process;endocytosis;response to stimulus;regulation of metabolic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;regulation of cell motility;transcription, DNA-templated;positive regulation of cell motility;circulatory system development;positive regulation of response to external stimulus;regulation of response to external stimulus;regulation of cell adhesion;positive regulation of nitrogen compound metabolic process;regulation of cellular biosynthetic process;regulation of cellular component organization;positive regulation of signaling;cellular nitrogen compound metabolic process;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;response to endogenous stimulus;homophilic cell adhesion via plasma membrane adhesion molecules;vasculature development;epithelial cell proliferation;cell projection assembly;biological adhesion;lamellipodium assembly;cellular response to endogenous stimulus;negative regulation of cell proliferation;multicellular organismal process;response to low-density lipoprotein particle;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of vesicle-mediated transport;regulation of cellular component movement;cell-cell junction organization;cellular nitrogen compound biosynthetic process;regulation of localization;positive regulation of metabolic process;tissue migration;cell cycle;regulation of epithelial cell proliferation;cellular response to low-density lipoprotein particle stimulus;positive regulation of cell-matrix adhesion;regulation of cell-matrix adhesion;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;system development;organic cyclic compound metabolic process;developmental process;anatomical structure development;RNA biosynthetic process;positive regulation of cellular biosynthetic process;cell projection organization;adherens junction organization;calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;cell junction organization;regulation of cellular metabolic process;cell-substrate adhesion;regulation of epidermal growth factor receptor signaling pathway;nucleic acid metabolic process;macromolecule metabolic process;cellular metabolic process;low-density lipoprotein particle mediated signaling;lipoprotein particle mediated signaling;response to lipoprotein particle;positive regulation of gene expression;angiogenesis;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;multicellular organism development;positive regulation of nucleic acid-templated transcription;cellular response to organic substance;cellular component biogenesis;cell junction assembly;regulation of gene expression;positive regulation of calcium-mediated signaling;positive regulation of cell migration;regulation of cell migration;positive regulation of nucleobase-containing compound metabolic process;mitotic cell cycle;regulation of smooth muscle cell proliferation;positive regulation of smooth muscle cell proliferation;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;cellular biosynthetic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;lamellipodium organization;cell adhesion;response to chemical;Ras protein signal transduction;small GTPase mediated signal transduction;regulation of endocytosis;localization;cellular localization;locomotion;positive regulation of cellular component movement;regulation of locomotion;positive regulation of locomotion;positive regulation of cellular metabolic process;positive regulation of endothelial cell proliferation;regulation of endothelial cell proliferation;endothelial cell proliferation;negative regulation of cellular process;positive regulation of cellular process; 3;4;3;5;4;5;3;3;6;5;4;5;4;4;5;6;7;5;2;3;3;4;4;4;5;5;3;4;2;2;5;5;4;4;7;4;5;5;9;6;4;4;5;6;3;3;3;5;5;3;5;4;4;5;4;4;5;4;5;4;4;3;6;5;2;7;7;4;3;8;4;8;4;3;5;5;2;6;7;4;5;3;5;4;4;4;4;4;3;5;1;2;5;5;5;5;4;5;6;2;3;6;7;4;6;4;5;4;4;4;4;5;4;3;4;2;8;4;3;4;4;2;3;6;5;4;5;2;6;4;4;2;5;3;2;4;7;4;4;5;5;3;3;4;4;5;6;6;6;6;3;7;4;4;2;3;6;5;4;6;6;4;4;4;6;5;4;3;6;5;4;5;4;6;5;4;7;5;3;5;5;6;5;5;5;5;5;5;5;5;4;3;3;5;3;4;5;3;3;7;6;5;2;3;2;4;3;3;4;6;6;5;3;3; GO:0098590;GO:0044853;GO:0030055;GO:0031982;GO:0016020;GO:0098589;GO:0042995;GO:0043230;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0009897;GO:0005925;GO:0043227;GO:0030054;GO:0048471;GO:0005737;GO:0070161;GO:0031224;GO:0044444;GO:0005901;GO:0031225;GO:1903561;GO:0043005;GO:0044459;GO:0009986;GO:0005912;GO:0070062;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098552;GO:0005924;GO:0005615;GO:0098805;GO:0097458;GO:0005886;GO:0045121;GO:0005575;GO:0005576;GO:0043226; plasma membrane region;plasma membrane raft;cell-substrate junction;vesicle;membrane;membrane region;cell projection;extracellular organelle;intracellular part;membrane part;membrane microdomain;extracellular region part;external side of plasma membrane;focal adhesion;membrane-bounded organelle;cell junction;perinuclear region of cytoplasm;cytoplasm;anchoring junction;intrinsic component of membrane;cytoplasmic part;caveola;anchored component of membrane;extracellular vesicle;neuron projection;plasma membrane part;cell surface;adherens junction;extracellular exosome;cell part;cell;intracellular;cell periphery;side of membrane;cell-substrate adherens junction;extracellular space;whole membrane;neuron part;plasma membrane;membrane raft;cellular_component;extracellular region;organelle; 4;4;3;4;2;3;3;3;3;2;4;2;4;5;3;2;5;4;3;3;4;5;4;3;4;3;3;4;4;2;2;3;3;3;4;3;3;3;3;5;1;2;2; GO:0050839;GO:0046872;GO:0044877;GO:0071813;GO:0003674;GO:0005488;GO:0055100;GO:0030169;GO:0043169;GO:0043167;GO:0005509;GO:0042562;GO:0071814;GO:0005515;GO:0045296; cell adhesion molecule binding;metal ion binding;macromolecular complex binding;lipoprotein particle binding;molecular_function;binding;adiponectin binding;low-density lipoprotein particle binding;cation binding;ion binding;calcium ion binding;hormone binding;protein-lipid complex binding;protein binding;cadherin binding; 4;5;3;5;1;2;4;6;4;3;6;3;4;3;5; K06808 IPR002126;IPR020894;IPR015919;IPR014868;IPR033216; Cadherin;Cadherin conserved site;Cadherin-like;Cadherin prodomain;Cadherin-13; endoplasmic reticulum Hs4502719 1459.0 S [S] Function unknown; Q4V328 GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2 - [GRAP1_HUMAN] 1.089 1.148 0.969 1.071 1.038 0.611 0.948606272 0.633044296 1.031791908 0.282676051 0.844076655 0.260477778 0.588631985 0.004188446 GO:0005737;GO:0043231;GO:0005773;GO:0043227;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044421;GO:0044444;GO:0005576;GO:0005615;GO:0012505;GO:0044424;GO:0005769;GO:0005768;GO:0043226;GO:0072562; cytoplasm;intracellular membrane-bounded organelle;vacuole;membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;extracellular region part;cytoplasmic part;extracellular region;extracellular space;endomembrane system;intracellular part;early endosome;endosome;organelle;blood microparticle; 4;4;5;3;2;3;2;3;1;2;4;2;3;3;3;5;4;2;3; IPR026204; GRIP1-associated protein 1; cytosol Q9NY35 Claudin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CLDND1 PE=1 SV=1 - [CLDN1_HUMAN] 1.157 1.037 0.767 0.96 1.029 1.949 1.115718419 nan 0.932944606 nan 0.739633558 nan 1.894071914 nan GO:0009986;GO:0016020;GO:0044464;GO:0005623;GO:0005575;GO:0044425;GO:0016021;GO:0031224; cell surface;membrane;cell part;cell;cellular_component;membrane part;integral component of membrane;intrinsic component of membrane; 3;2;2;2;1;2;4;3; IPR004031; PMP-22/EMP/MP20/Claudin superfamily; plasma membrane Q8IWE2 Protein NOXP20 OS=Homo sapiens OX=9606 GN=FAM114A1 PE=1 SV=2 - [NXP20_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; IPR007998; Protein of unknown function DUF719; nucleus P54132 Bloom syndrome protein OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1 - [BLM_HUMAN] 1.108 1.051 0.829 1.101 1.104 1.169 1.054234063 nan 0.997282609 nan 0.788772598 nan 1.058876812 nan GO:1903508;GO:0009628;GO:0019220;GO:0080090;GO:0019222;GO:0010564;GO:0000086;GO:2001141;GO:0043933;GO:1901362;GO:0071840;GO:0065003;GO:0044710;GO:0010605;GO:0006302;GO:0070647;GO:0010467;GO:0018193;GO:0032446;GO:0006260;GO:0006261;GO:0016310;GO:0048518;GO:0048519;GO:0031297;GO:0000077;GO:0032392;GO:0051053;GO:0051052;GO:0006281;GO:0060255;GO:0072711;GO:0072710;GO:0010035;GO:0044818;GO:0010033;GO:0046483;GO:0042325;GO:1901563;GO:0019538;GO:0010243;GO:0006275;GO:0010468;GO:0045910;GO:0033554;GO:0010628;GO:0019438;GO:1901990;GO:0071103;GO:0009892;GO:0070887;GO:0009890;GO:0009891;GO:0000018;GO:0000724;GO:0000278;GO:0044267;GO:0031572;GO:0044260;GO:0018205;GO:0043549;GO:0016043;GO:0009719;GO:0048478;GO:0065007;GO:1901360;GO:0065009;GO:0018130;GO:1901991;GO:0010165;GO:0050790;GO:0009889;GO:0051716;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:1901700;GO:0008152;GO:0007093;GO:0034654;GO:0045786;GO:0006310;GO:1901988;GO:0010604;GO:0016070;GO:0044271;GO:0043412;GO:0050896;GO:1901699;GO:0008156;GO:0051338;GO:0000733;GO:0010557;GO:0010556;GO:0006351;GO:0031570;GO:0097305;GO:0010558;GO:0097306;GO:1904029;GO:0032774;GO:0070271;GO:0009314;GO:0071241;GO:0044249;GO:0034641;GO:0022607;GO:0014070;GO:0071214;GO:0034645;GO:0090329;GO:0044699;GO:0009893;GO:0006139;GO:0071479;GO:0071478;GO:0010212;GO:0000725;GO:0051246;GO:0031399;GO:1901987;GO:0071495;GO:0045005;GO:1901701;GO:0032508;GO:0009987;GO:0006725;GO:1903506;GO:0006974;GO:0000729;GO:0045893;GO:0043279;GO:0016925;GO:0051259;GO:0044770;GO:0007049;GO:0032268;GO:0000075;GO:0071407;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0006807;GO:0010972;GO:0044774;GO:1901698;GO:0072757;GO:0051782;GO:0044839;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0051174;GO:1903047;GO:0090304;GO:0044772;GO:0044773;GO:0022402;GO:0007346;GO:0051301;GO:0051302;GO:0071900;GO:0071822;GO:0006355;GO:0071417;GO:2000112;GO:2000113;GO:0050789;GO:0071312;GO:0071704;GO:0071310;GO:0010948;GO:0043687;GO:1902750;GO:0045930;GO:0006468;GO:0045859;GO:0045935;GO:0045934;GO:1901576;GO:0019219;GO:0006461;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0042221;GO:0010389;GO:0006996;GO:0044238;GO:0051276;GO:0045003;GO:0051726;GO:2000104;GO:0000079;GO:0044237;GO:0006796;GO:0044085;GO:1902749;GO:0006793;GO:0006259;GO:0007095;GO:0001932;GO:0097659;GO:0048523;GO:0048522; positive regulation of nucleic acid-templated transcription;response to abiotic stimulus;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of cell cycle process;G2/M transition of mitotic cell cycle;regulation of RNA biosynthetic process;macromolecular complex subunit organization;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;macromolecular complex assembly;single-organism metabolic process;negative regulation of macromolecule metabolic process;double-strand break repair;protein modification by small protein conjugation or removal;gene expression;peptidyl-amino acid modification;protein modification by small protein conjugation;DNA replication;DNA-dependent DNA replication;phosphorylation;positive regulation of biological process;negative regulation of biological process;replication fork processing;DNA damage checkpoint;DNA geometric change;negative regulation of DNA metabolic process;regulation of DNA metabolic process;DNA repair;regulation of macromolecule metabolic process;cellular response to hydroxyurea;response to hydroxyurea;response to inorganic substance;mitotic G2/M transition checkpoint;response to organic substance;heterocycle metabolic process;regulation of phosphorylation;response to camptothecin;protein metabolic process;response to organonitrogen compound;regulation of DNA replication;regulation of gene expression;negative regulation of DNA recombination;cellular response to stress;positive regulation of gene expression;aromatic compound biosynthetic process;regulation of mitotic cell cycle phase transition;DNA conformation change;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of biosynthetic process;positive regulation of biosynthetic process;regulation of DNA recombination;double-strand break repair via homologous recombination;mitotic cell cycle;cellular protein metabolic process;G2 DNA damage checkpoint;cellular macromolecule metabolic process;peptidyl-lysine modification;regulation of kinase activity;cellular component organization;response to endogenous stimulus;replication fork protection;biological regulation;organic cyclic compound metabolic process;regulation of molecular function;heterocycle biosynthetic process;negative regulation of mitotic cell cycle phase transition;response to X-ray;regulation of catalytic activity;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;response to stress;protein modification process;biological_process;response to oxygen-containing compound;metabolic process;mitotic cell cycle checkpoint;nucleobase-containing compound biosynthetic process;negative regulation of cell cycle;DNA recombination;negative regulation of cell cycle phase transition;positive regulation of macromolecule metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;macromolecule modification;response to stimulus;cellular response to nitrogen compound;negative regulation of DNA replication;regulation of transferase activity;DNA strand renaturation;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA integrity checkpoint;response to alcohol;negative regulation of macromolecule biosynthetic process;cellular response to alcohol;regulation of cyclin-dependent protein kinase activity;RNA biosynthetic process;protein complex biogenesis;response to radiation;cellular response to inorganic substance;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular component assembly;response to organic cyclic compound;cellular response to abiotic stimulus;cellular macromolecule biosynthetic process;regulation of DNA-dependent DNA replication;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;cellular response to ionizing radiation;cellular response to radiation;response to ionizing radiation;recombinational repair;regulation of protein metabolic process;regulation of protein modification process;regulation of cell cycle phase transition;cellular response to endogenous stimulus;DNA-dependent DNA replication maintenance of fidelity;cellular response to oxygen-containing compound;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;DNA double-strand break processing;positive regulation of transcription, DNA-templated;response to alkaloid;protein sumoylation;protein oligomerization;cell cycle phase transition;cell cycle;regulation of cellular protein metabolic process;cell cycle checkpoint;cellular response to organic cyclic compound;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;negative regulation of G2/M transition of mitotic cell cycle;mitotic DNA integrity checkpoint;response to nitrogen compound;cellular response to camptothecin;negative regulation of cell division;cell cycle G2/M phase transition;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of phosphorus metabolic process;mitotic cell cycle process;nucleic acid metabolic process;mitotic cell cycle phase transition;mitotic DNA damage checkpoint;cell cycle process;regulation of mitotic cell cycle;cell division;regulation of cell division;regulation of protein serine/threonine kinase activity;protein complex subunit organization;regulation of transcription, DNA-templated;cellular response to organonitrogen compound;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;cellular response to alkaloid;organic substance metabolic process;cellular response to organic substance;negative regulation of cell cycle process;post-translational protein modification;negative regulation of cell cycle G2/M phase transition;negative regulation of mitotic cell cycle;protein phosphorylation;regulation of protein kinase activity;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;protein complex assembly;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;regulation of G2/M transition of mitotic cell cycle;organelle organization;primary metabolic process;chromosome organization;double-strand break repair via synthesis-dependent strand annealing;regulation of cell cycle;negative regulation of DNA-dependent DNA replication;regulation of cyclin-dependent protein serine/threonine kinase activity;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;regulation of cell cycle G2/M phase transition;phosphorus metabolic process;DNA metabolic process;mitotic G2 DNA damage checkpoint;regulation of protein phosphorylation;nucleic acid-templated transcription;negative regulation of cellular process;positive regulation of cellular process; 7;3;6;4;3;5;6;6;4;5;2;5;3;4;5;7;5;7;8;6;7;6;2;2;4;6;7;5;5;4;4;6;5;4;7;4;4;7;6;4;4;6;5;6;4;5;5;6;6;3;4;4;4;6;6;5;5;7;4;8;6;3;3;7;2;4;3;5;6;6;4;4;3;3;3;5;1;4;2;6;5;4;6;6;4;5;5;5;2;5;6;5;6;5;5;6;6;5;5;6;5;6;4;4;5;4;4;4;5;4;5;7;2;3;4;6;5;5;5;5;6;6;4;6;5;8;2;4;7;5;6;6;5;9;6;5;4;5;5;6;5;5;4;6;3;7;6;4;7;4;6;5;5;5;4;4;4;5;5;5;6;6;4;5;4;4;8;5;6;5;6;6;2;6;3;5;5;7;7;5;7;7;5;5;4;5;5;6;3;5;3;4;4;4;3;7;4;3;5;7;4;7;6;3;5;3;7;4;5;6;7;7;3;3; GO:0031974;GO:0031981;GO:0000793;GO:0000794;GO:0000795;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0043228;GO:0000228;GO:0005622;GO:0043227;GO:0043226;GO:0016605;GO:0016604;GO:0005654;GO:0016363;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0000800;GO:0044454;GO:0044451;GO:0044464;GO:0005623;GO:0005694;GO:0034399;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;condensed chromosome;condensed nuclear chromosome;synaptonemal complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome;intracellular;membrane-bounded organelle;organelle;PML body;nuclear body;nucleoplasm;nuclear matrix;intracellular organelle part;cytoplasm;nucleolus;nucleus;lateral element;nuclear chromosome part;nucleoplasm part;cell part;cell;chromosome;nuclear periphery;cellular_component;intracellular organelle lumen; 2;5;6;6;6;4;4;3;4;3;4;2;3;3;5;3;3;2;7;6;5;5;3;4;5;5;6;5;5;2;2;5;5;1;4; GO:1901363;GO:0097367;GO:0000166;GO:0004386;GO:0016818;GO:0016817;GO:0070035;GO:0009378;GO:0003674;GO:0005488;GO:0016887;GO:0003677;GO:0003678;GO:1901265;GO:0042623;GO:0043140;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0008094;GO:0043138;GO:0000405;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032553;GO:0008026;GO:0035639;GO:0043168;GO:0043167;GO:0003697;GO:0030554;GO:0005515;GO:0002039;GO:0003676;GO:0000217;GO:0097617;GO:0032550;GO:0001882;GO:0001883;GO:0004003;GO:0017111;GO:0036094;GO:0043566;GO:0036310;GO:0051880; heterocyclic compound binding;carbohydrate derivative binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;four-way junction helicase activity;molecular_function;binding;ATPase activity;DNA binding;DNA helicase activity;nucleoside phosphate binding;ATPase activity, coupled;ATP-dependent 3'-5' DNA helicase activity;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;DNA-dependent ATPase activity;3'-5' DNA helicase activity;bubble DNA binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;anion binding;ion binding;single-stranded DNA binding;adenyl nucleotide binding;protein binding;p53 binding;nucleic acid binding;DNA secondary structure binding;annealing activity;purine ribonucleoside binding;nucleoside binding;purine nucleoside binding;ATP-dependent DNA helicase activity;nucleoside-triphosphatase activity;small molecule binding;structure-specific DNA binding;annealing helicase activity;G-quadruplex DNA binding; 3;3;4;8;5;4;9;10;1;2;8;5;9;4;9;11;5;5;6;3;2;10;10;8;3;6;6;5;4;10;5;4;3;6;6;3;4;4;7;5;6;4;5;10;7;3;6;6;7; K10901 map03440;map03460; Homologous recombination;Fanconi anemia pathway; IPR004589;IPR002121;IPR011545;IPR032284;IPR032439;IPR001650;IPR002464;IPR018982;IPR014001;IPR011991;IPR032437;IPR012532;IPR027417;IPR010997; DNA helicase, ATP-dependent, RecQ type;HRDC domain;DEAD/DEAH box helicase domain;ATP-dependent DNA helicase RecQ, zinc-binding domain;Bloom syndrome protein, BDHCT-box associated domain;Helicase, C-terminal;DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;RQC domain;Helicase superfamily 1/2, ATP-binding domain;Winged helix-turn-helix DNA-binding domain;Bloom syndrome protein, N-terminal domain;BDHCT;P-loop containing nucleoside triphosphate hydrolase;HRDC-like; nucleus Hs4557365 2944.0 L [L] Replication, recombination and repair; Q13418 Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2 - [ILK_HUMAN] 0.808 1.134 1.317 0.843 0.966 1.124 0.712522046 0.167490535 0.872670807 0.033110718 1.161375661 0.310580009 1.163561077 0.030161805 GO:0007599;GO:0007596;GO:0016358;GO:0001503;GO:0003151;GO:0051716;GO:0019222;GO:0043206;GO:0051493;GO:0050775;GO:1990138;GO:0048583;GO:0045859;GO:0051291;GO:0008361;GO:0008366;GO:0046483;GO:0042325;GO:0042327;GO:0042326;GO:0019538;GO:0050772;GO:0072359;GO:0042692;GO:0001954;GO:0009892;GO:0009893;GO:0009891;GO:0090263;GO:0014812;GO:0001952;GO:0030177;GO:0031175;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0000904;GO:0042552;GO:0000902;GO:0051348;GO:0018130;GO:0098602;GO:0098609;GO:0016310;GO:0007050;GO:0043412;GO:0032956;GO:0014037;GO:0016070;GO:0010557;GO:0048812;GO:0048814;GO:0009967;GO:0048639;GO:0048638;GO:0000165;GO:0051128;GO:0010001;GO:0060284;GO:0008284;GO:0008285;GO:0035239;GO:0050878;GO:0008283;GO:0001558;GO:0007409;GO:0001657;GO:0001658;GO:0034329;GO:0007229;GO:0018105;GO:0045927;GO:0030030;GO:0032288;GO:0030036;GO:0022402;GO:0045445;GO:0007272;GO:0008219;GO:2000112;GO:0007275;GO:0043067;GO:0043066;GO:0043062;GO:0043069;GO:0006468;GO:0006469;GO:0019219;GO:0006461;GO:0006464;GO:0044767;GO:0044763;GO:0040011;GO:0051272;GO:0051271;GO:0051270;GO:0048858;GO:0040017;GO:0048856;GO:0035295;GO:0006796;GO:2000026;GO:0006793;GO:0048523;GO:0048522;GO:0048675;GO:0051347;GO:0034446;GO:0007160;GO:0007163;GO:0043524;GO:0007165;GO:0007166;GO:0007167;GO:0031344;GO:0031346;GO:0044710;GO:0045786;GO:0045785;GO:0070848;GO:0045664;GO:0045667;GO:0045666;GO:0045661;GO:0045663;GO:0044092;GO:0060993;GO:0045669;GO:2001141;GO:0010033;GO:0018209;GO:0061333;GO:0006807;GO:0010647;GO:0044267;GO:0009653;GO:0044260;GO:0070997;GO:0070271;GO:0007049;GO:0006366;GO:0009887;GO:0050793;GO:0050790;GO:0009889;GO:0009888;GO:0050794;GO:0060070;GO:0051239;GO:1901214;GO:1901215;GO:0050896;GO:0051338;GO:0051962;GO:0051960;GO:2000145;GO:0032535;GO:2000147;GO:2000146;GO:0033674;GO:0010562;GO:0022604;GO:0033043;GO:0043406;GO:0043405;GO:0070887;GO:0044699;GO:0043408;GO:0050767;GO:0051248;GO:0051240;GO:0010563;GO:0051246;GO:0051247;GO:0050769;GO:0010769;GO:0031399;GO:0010761;GO:0014912;GO:0040013;GO:0040012;GO:0072171;GO:0021675;GO:0090287;GO:1902680;GO:0048731;GO:0072088;GO:0061326;GO:0043933;GO:0034330;GO:0010667;GO:0010665;GO:0010664;GO:0001763;GO:0010662;GO:0051147;GO:0010660;GO:0051149;GO:0001649;GO:1901360;GO:0061351;GO:0045935;GO:0030029;GO:0045936;GO:0010811;GO:0072078;GO:0042221;GO:0022008;GO:0006996;GO:0007507;GO:0044237;GO:0019220;GO:0048589;GO:0048588;GO:0048584;GO:0048468;GO:0030509;GO:0030111;GO:0072358;GO:0060548;GO:1901362;GO:0071840;GO:0009966;GO:0048869;GO:0001823;GO:0001822;GO:0048513;GO:0010720;GO:0048518;GO:0048519;GO:0042127;GO:0031589;GO:0003007;GO:0007178;GO:0044700;GO:0044707;GO:0016055;GO:0033002;GO:0043523;GO:0048646;GO:0060828;GO:0033673;GO:0022607;GO:0061245;GO:0022603;GO:0006928;GO:0051674;GO:0043170;GO:0042981;GO:0097659;GO:0090100;GO:0043549;GO:0090066;GO:0072080;GO:0016477;GO:0061564;GO:0012501;GO:0001775;GO:0050817;GO:0010658;GO:0010659;GO:0010656;GO:0010657;GO:0030278;GO:1902531;GO:0043410;GO:0044271;GO:0031400;GO:0031401;GO:0006950;GO:0006355;GO:0006357;GO:0006351;GO:0009719;GO:0032774;GO:0030155;GO:0030154;GO:0010927;GO:1902533;GO:0061061;GO:0016337;GO:0006139;GO:2000177;GO:0032270;GO:0031326;GO:0060562;GO:0060560;GO:2000178;GO:0032502;GO:0014909;GO:0044093;GO:0032970;GO:0006725;GO:1903506;GO:0072009;GO:0072163;GO:0072164;GO:0072001;GO:0032879;GO:0072006;GO:0051259;GO:0071363;GO:0050770;GO:0050773;GO:0051252;GO:0051254;GO:0072028;GO:0010770;GO:0048754;GO:0022011;GO:0045937;GO:1900006;GO:0048813;GO:0032989;GO:0071704;GO:0071310;GO:0010556;GO:0048729;GO:0030336;GO:0030335;GO:0030334;GO:0006915;GO:0051174;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0051179;GO:0051726;GO:0071495;GO:1902589;GO:0034654;GO:0080090;GO:0090092;GO:0061387;GO:0051897;GO:0051896;GO:0023014;GO:0010605;GO:0010604;GO:0009611;GO:0018193;GO:0060255;GO:0010976;GO:0010975;GO:0030516;GO:0030513;GO:0030168;GO:0030510;GO:0048870;GO:0030198;GO:0019438;GO:0021782;GO:0045197;GO:0060675;GO:1901576;GO:0035088;GO:0016049;GO:0030182;GO:0061138;GO:0016043;GO:0065003;GO:0010810;GO:0065007;GO:0065009;GO:0065008;GO:0051130;GO:0042063;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0043491;GO:0048659;GO:0097435;GO:0071772;GO:0071773;GO:0030307;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0001667;GO:0010646;GO:0043086;GO:0043085;GO:0022610;GO:0032292;GO:0044238;GO:0060429;GO:0045597;GO:0045595;GO:0045893;GO:0032269;GO:0032268;GO:0007568;GO:0007569;GO:0051094;GO:0010628;GO:0045860;GO:1903508;GO:0031328;GO:0014910;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0032501;GO:0010941;GO:0072073;GO:0002009;GO:0040007;GO:0071822;GO:0040008;GO:0010467;GO:0010468;GO:0048666;GO:0048667;GO:0009987;GO:0048662;GO:0048660;GO:0034109;GO:0051402;GO:0014044;GO:0007422;GO:0007155;GO:0007154;GO:0048699;GO:0007010;GO:0032990;GO:0007399;GO:0045778;GO:0045773;GO:0070527;GO:0044085;GO:0001933;GO:0001932;GO:0001934;GO:0001655; hemostasis;blood coagulation;dendrite development;ossification;outflow tract morphogenesis;cellular response to stimulus;regulation of metabolic process;extracellular fibril organization;regulation of cytoskeleton organization;positive regulation of dendrite morphogenesis;neuron projection extension;regulation of response to stimulus;regulation of protein kinase activity;protein heterooligomerization;regulation of cell size;axon ensheathment;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;negative regulation of phosphorylation;protein metabolic process;positive regulation of axonogenesis;circulatory system development;muscle cell differentiation;positive regulation of cell-matrix adhesion;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of canonical Wnt signaling pathway;muscle cell migration;regulation of cell-matrix adhesion;positive regulation of Wnt signaling pathway;neuron projection development;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cell morphogenesis involved in differentiation;myelination;cell morphogenesis;negative regulation of transferase activity;heterocycle biosynthetic process;single organism cell adhesion;cell-cell adhesion;phosphorylation;cell cycle arrest;macromolecule modification;regulation of actin cytoskeleton organization;Schwann cell differentiation;RNA metabolic process;positive regulation of macromolecule biosynthetic process;neuron projection morphogenesis;regulation of dendrite morphogenesis;positive regulation of signal transduction;positive regulation of developmental growth;regulation of developmental growth;MAPK cascade;regulation of cellular component organization;glial cell differentiation;regulation of cell development;positive regulation of cell proliferation;negative regulation of cell proliferation;tube morphogenesis;regulation of body fluid levels;cell proliferation;regulation of cell growth;axonogenesis;ureteric bud development;branching involved in ureteric bud morphogenesis;cell junction assembly;integrin-mediated signaling pathway;peptidyl-serine phosphorylation;positive regulation of growth;cell projection organization;myelin assembly;actin cytoskeleton organization;cell cycle process;myoblast differentiation;ensheathment of neurons;cell death;regulation of cellular macromolecule biosynthetic process;multicellular organism development;regulation of programmed cell death;negative regulation of apoptotic process;extracellular structure organization;negative regulation of programmed cell death;protein phosphorylation;negative regulation of protein kinase activity;regulation of nucleobase-containing compound metabolic process;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism cellular process;locomotion;positive regulation of cellular component movement;negative regulation of cellular component movement;regulation of cellular component movement;cell projection morphogenesis;positive regulation of locomotion;anatomical structure development;tube development;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;axon extension;positive regulation of transferase activity;substrate adhesion-dependent cell spreading;cell-matrix adhesion;establishment or maintenance of cell polarity;negative regulation of neuron apoptotic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of cell projection organization;positive regulation of cell projection organization;single-organism metabolic process;negative regulation of cell cycle;positive regulation of cell adhesion;response to growth factor;regulation of neuron differentiation;regulation of osteoblast differentiation;positive regulation of neuron differentiation;regulation of myoblast differentiation;positive regulation of myoblast differentiation;negative regulation of molecular function;kidney morphogenesis;positive regulation of osteoblast differentiation;regulation of RNA biosynthetic process;response to organic substance;peptidyl-serine modification;renal tubule morphogenesis;nitrogen compound metabolic process;positive regulation of cell communication;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;neuron death;protein complex biogenesis;cell cycle;transcription from RNA polymerase II promoter;organ morphogenesis;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;tissue development;regulation of cellular process;canonical Wnt signaling pathway;regulation of multicellular organismal process;regulation of neuron death;negative regulation of neuron death;response to stimulus;regulation of transferase activity;positive regulation of nervous system development;regulation of nervous system development;regulation of cell motility;regulation of cellular component size;positive regulation of cell motility;negative regulation of cell motility;positive regulation of kinase activity;positive regulation of phosphorus metabolic process;regulation of cell morphogenesis;regulation of organelle organization;positive regulation of MAP kinase activity;regulation of MAP kinase activity;cellular response to chemical stimulus;single-organism process;regulation of MAPK cascade;regulation of neurogenesis;negative regulation of protein metabolic process;positive regulation of multicellular organismal process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;fibroblast migration;negative regulation of smooth muscle cell migration;negative regulation of locomotion;regulation of locomotion;mesonephric tubule morphogenesis;nerve development;regulation of cellular response to growth factor stimulus;positive regulation of RNA biosynthetic process;system development;nephron epithelium morphogenesis;renal tubule development;macromolecular complex subunit organization;cell junction organization;negative regulation of cardiac muscle cell apoptotic process;regulation of cardiac muscle cell apoptotic process;negative regulation of striated muscle cell apoptotic process;morphogenesis of a branching structure;regulation of striated muscle cell apoptotic process;regulation of muscle cell differentiation;regulation of muscle cell apoptotic process;positive regulation of muscle cell differentiation;osteoblast differentiation;organic cyclic compound metabolic process;neural precursor cell proliferation;positive regulation of nucleobase-containing compound metabolic process;actin filament-based process;negative regulation of phosphate metabolic process;positive regulation of cell-substrate adhesion;nephron tubule morphogenesis;response to chemical;neurogenesis;organelle organization;heart development;cellular metabolic process;regulation of phosphate metabolic process;developmental growth;developmental cell growth;positive regulation of response to stimulus;cell development;BMP signaling pathway;regulation of Wnt signaling pathway;cardiovascular system development;negative regulation of cell death;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;regulation of signal transduction;cellular developmental process;mesonephros development;kidney development;animal organ development;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;heart morphogenesis;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;single-multicellular organism process;Wnt signaling pathway;muscle cell proliferation;regulation of neuron apoptotic process;anatomical structure formation involved in morphogenesis;regulation of canonical Wnt signaling pathway;negative regulation of kinase activity;cellular component assembly;establishment or maintenance of bipolar cell polarity;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;macromolecule metabolic process;regulation of apoptotic process;nucleic acid-templated transcription;positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of kinase activity;regulation of anatomical structure size;nephron tubule development;cell migration;axon development;programmed cell death;cell activation;coagulation;striated muscle cell apoptotic process;cardiac muscle cell apoptotic process;negative regulation of muscle cell apoptotic process;muscle cell apoptotic process;regulation of ossification;regulation of intracellular signal transduction;positive regulation of MAPK cascade;cellular nitrogen compound biosynthetic process;negative regulation of protein modification process;positive regulation of protein modification process;response to stress;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;response to endogenous stimulus;RNA biosynthetic process;regulation of cell adhesion;cell differentiation;cellular component assembly involved in morphogenesis;positive regulation of intracellular signal transduction;muscle structure development;single organismal cell-cell adhesion;nucleobase-containing compound metabolic process;regulation of neural precursor cell proliferation;positive regulation of cellular protein metabolic process;regulation of cellular biosynthetic process;epithelial tube morphogenesis;developmental growth involved in morphogenesis;negative regulation of neural precursor cell proliferation;developmental process;smooth muscle cell migration;positive regulation of molecular function;regulation of actin filament-based process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;nephron epithelium development;mesonephric epithelium development;mesonephric tubule development;renal system development;regulation of localization;nephron development;protein oligomerization;cellular response to growth factor stimulus;regulation of axonogenesis;regulation of dendrite development;regulation of RNA metabolic process;positive regulation of RNA metabolic process;nephron morphogenesis;positive regulation of cell morphogenesis involved in differentiation;branching morphogenesis of an epithelial tube;myelination in peripheral nervous system;positive regulation of phosphate metabolic process;positive regulation of dendrite development;dendrite morphogenesis;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;regulation of macromolecule biosynthetic process;tissue morphogenesis;negative regulation of cell migration;positive regulation of cell migration;regulation of cell migration;apoptotic process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;localization;regulation of cell cycle;cellular response to endogenous stimulus;single-organism organelle organization;nucleobase-containing compound biosynthetic process;regulation of primary metabolic process;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of extent of cell growth;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;signal transduction by protein phosphorylation;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;response to wounding;peptidyl-amino acid modification;regulation of macromolecule metabolic process;positive regulation of neuron projection development;regulation of neuron projection development;regulation of axon extension;positive regulation of BMP signaling pathway;platelet activation;regulation of BMP signaling pathway;cell motility;extracellular matrix organization;aromatic compound biosynthetic process;glial cell development;establishment or maintenance of epithelial cell apical/basal polarity;ureteric bud morphogenesis;organic substance biosynthetic process;establishment or maintenance of apical/basal cell polarity;cell growth;neuron differentiation;morphogenesis of a branching epithelium;cellular component organization;macromolecular complex assembly;regulation of cell-substrate adhesion;biological regulation;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;gliogenesis;wound healing;protein modification process;biological_process;metabolic process;protein kinase B signaling;smooth muscle cell proliferation;fibril organization;response to BMP;cellular response to BMP stimulus;positive regulation of cell growth;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;ameboidal-type cell migration;regulation of cell communication;negative regulation of catalytic activity;positive regulation of catalytic activity;biological adhesion;peripheral nervous system axon ensheathment;primary metabolic process;epithelium development;positive regulation of cell differentiation;regulation of cell differentiation;positive regulation of transcription, DNA-templated;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;aging;cell aging;positive regulation of developmental process;positive regulation of gene expression;positive regulation of protein kinase activity;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of smooth muscle cell migration;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organismal process;regulation of cell death;kidney epithelium development;morphogenesis of an epithelium;growth;protein complex subunit organization;regulation of growth;gene expression;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;cellular process;negative regulation of smooth muscle cell proliferation;regulation of smooth muscle cell proliferation;homotypic cell-cell adhesion;neuron apoptotic process;Schwann cell development;peripheral nervous system development;cell adhesion;cell communication;generation of neurons;cytoskeleton organization;cell part morphogenesis;nervous system development;positive regulation of ossification;positive regulation of axon extension;platelet aggregation;cellular component biogenesis;negative regulation of protein phosphorylation;regulation of protein phosphorylation;positive regulation of protein phosphorylation;urogenital system development; 5;5;4;4;4;3;3;7;6;6;5;3;7;7;5;5;4;7;7;7;4;6;5;5;6;3;3;4;6;5;6;5;5;9;5;8;2;5;6;5;6;5;3;4;6;5;5;5;6;5;5;6;6;4;4;4;5;4;6;5;4;4;4;4;3;4;7;6;6;5;6;8;3;4;5;5;4;6;4;4;6;4;5;6;4;5;7;8;5;5;6;3;3;2;4;4;4;5;3;3;4;5;4;4;3;3;6;6;4;5;4;6;4;5;6;5;5;3;4;4;5;7;5;6;6;6;4;5;5;6;4;8;6;3;4;5;3;4;5;4;4;7;4;3;4;4;4;3;7;3;5;5;2;5;4;5;4;4;4;4;7;5;5;5;7;7;4;2;6;6;5;3;5;5;5;5;6;6;6;6;3;3;6;4;4;6;4;5;5;4;4;9;9;8;4;8;5;7;5;5;4;4;5;4;6;5;6;3;6;4;4;3;6;3;4;3;4;6;5;5;4;5;2;4;4;5;4;4;5;2;2;4;4;5;7;3;3;6;4;6;3;6;7;4;5;4;4;3;4;6;7;5;6;4;6;4;6;5;4;4;8;9;7;7;4;5;6;5;6;6;3;6;7;6;3;6;4;5;4;5;4;4;4;5;5;5;5;4;5;2;6;4;4;4;7;5;6;5;5;3;4;6;6;7;5;5;5;4;5;5;7;6;5;5;4;3;5;5;4;5;5;5;6;5;3;5;4;4;2;4;4;4;5;4;5;5;6;6;4;4;4;4;7;4;6;6;5;6;5;5;3;5;5;5;7;7;4;6;3;6;5;3;5;5;2;3;3;4;7;5;5;1;2;6;5;6;4;5;4;3;4;4;2;5;3;5;4;5;5;2;6;3;5;4;4;6;5;5;4;5;3;5;8;7;5;6;4;4;4;5;2;4;5;5;2;5;3;5;5;5;6;2;5;5;5;6;6;5;3;4;7;5;5;5;4;5;6;3;7;7;7;5; GO:0005911;GO:0044428;GO:0044424;GO:0044422;GO:0005654;GO:0030054;GO:0043025;GO:0070161;GO:0031252;GO:0042641;GO:0005912;GO:0044463;GO:0044464;GO:0071944;GO:0001725;GO:0070013;GO:0097517;GO:0016020;GO:0044297;GO:0042995;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0005924;GO:0005925;GO:0044430;GO:0043228;GO:0044306;GO:0043227;GO:0030027;GO:0043679;GO:0043195;GO:0043198;GO:0043292;GO:0032432;GO:0031974;GO:0030055;GO:0036477;GO:0043229;GO:0043226;GO:0005856;GO:0044446;GO:0044444;GO:0044449;GO:0030016;GO:0030017;GO:0005634;GO:0043005;GO:0045202;GO:0015629;GO:0030425;GO:0030424;GO:0031981;GO:0031012;GO:0043034;GO:0005737;GO:0033267;GO:0044456;GO:0032991;GO:0005623;GO:0005622;GO:0097458;GO:0005886;GO:0005575;GO:0098793; cell-cell junction;nuclear part;intracellular part;organelle part;nucleoplasm;cell junction;neuronal cell body;anchoring junction;cell leading edge;actomyosin;adherens junction;cell projection part;cell part;cell periphery;stress fiber;intracellular organelle lumen;contractile actin filament bundle;membrane;cell body;cell projection;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;cell-substrate adherens junction;focal adhesion;cytoskeletal part;non-membrane-bounded organelle;neuron projection terminus;membrane-bounded organelle;lamellipodium;axon terminus;terminal bouton;dendritic shaft;contractile fiber;actin filament bundle;membrane-enclosed lumen;cell-substrate junction;somatodendritic compartment;intracellular organelle;organelle;cytoskeleton;intracellular organelle part;cytoplasmic part;contractile fiber part;myofibril;sarcomere;nucleus;neuron projection;synapse;actin cytoskeleton;dendrite;axon;nuclear lumen;extracellular matrix;costamere;cytoplasm;axon part;synapse part;macromolecular complex;cell;intracellular;neuron part;plasma membrane;cellular_component;presynapse; 3;4;3;2;5;2;4;3;3;5;4;3;2;3;6;4;6;2;3;3;3;4;4;3;5;4;5;4;3;4;3;4;5;4;4;5;5;2;3;4;3;2;5;3;4;3;6;4;5;4;2;6;5;5;5;2;4;4;4;2;2;2;3;3;3;1;3; GO:0000166;GO:0005488;GO:1901265;GO:0017076;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0001883;GO:0001882;GO:0036094;GO:0019899;GO:0005515;GO:0004674;GO:0004672;GO:0019901;GO:1901363;GO:0019900;GO:0003674;GO:0005524;GO:0016301;GO:0003824;GO:0097159;GO:0043168;GO:0016740;GO:0043167;GO:0030554;GO:0097367;GO:0032549;GO:0035639;GO:0004871; nucleotide binding;binding;nucleoside phosphate binding;purine nucleotide binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine nucleoside binding;nucleoside binding;small molecule binding;enzyme binding;protein binding;protein serine/threonine kinase activity;protein kinase activity;protein kinase binding;heterocyclic compound binding;kinase binding;molecular_function;ATP binding;kinase activity;catalytic activity;organic cyclic compound binding;anion binding;transferase activity;ion binding;adenyl nucleotide binding;carbohydrate derivative binding;ribonucleoside binding;purine ribonucleoside triphosphate binding;signal transducer activity; 4;2;4;5;5;4;6;5;6;4;5;4;3;4;3;7;6;6;3;5;1;6;5;2;3;4;3;3;6;3;5;5;2; K06272 map03320;map04360;map04510;map05100;map05213; PPAR signaling pathway;Axon guidance;Focal adhesion;Bacterial invasion of epithelial cells;Endometrial cancer; IPR002110;IPR011009;IPR000719;IPR001245;IPR020683;IPR035692; Ankyrin repeat;Protein kinase-like domain;Protein kinase domain;Serine-threonine/tyrosine-protein kinase, catalytic domain;Ankyrin repeat-containing domain;Integrin-linked protein kinase, pseudokinase domain; cytosol Hs4758606 946.0 T [T] Signal transduction mechanisms; Q8N7Z5 Putative ankyrin repeat domain-containing protein 31 OS=Homo sapiens OX=9606 GN=ANKRD31 PE=5 SV=2 - [ANR31_HUMAN] 0.762 0.585 2.049 0.782 0.62 1.479 1.302564103 nan 1.261290323 nan 3.502564103 nan 2.385483871 nan IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; nucleus Hs22052119 3537.0 S [S] Function unknown; P01009 Alpha-1-antitrypsin OS=Homo sapiens OX=9606 GN=SERPINA1 PE=1 SV=3 - [A1AT_HUMAN] 0.962 0.91 1.192 1.008 0.95 0.949 1.057142857 8.29E-31 1.061052632 3.50E-58 1.30989011 nan 0.998947368 2.55E-133 GO:0007599;GO:0019222;GO:0007596;GO:0006901;GO:0006900;GO:0061024;GO:1901576;GO:0051656;GO:0051650;GO:0071840;GO:0080090;GO:0044710;GO:0009611;GO:0018193;GO:0010466;GO:0044092;GO:0048519;GO:0010605;GO:0060255;GO:0032268;GO:0030162;GO:0006903;GO:0051668;GO:0030168;GO:0016192;GO:0044707;GO:0016050;GO:0050789;GO:0019538;GO:0022607;GO:0009892;GO:0043170;GO:0044267;GO:0006888;GO:0051346;GO:0044260;GO:0006887;GO:0016043;GO:0045055;GO:0065003;GO:0065007;GO:0065009;GO:0065008;GO:0006810;GO:0051248;GO:0042060;GO:0050794;GO:0006952;GO:0006953;GO:0006950;GO:0050817;GO:0044802;GO:0008152;GO:0044723;GO:0002526;GO:0051234;GO:0051336;GO:0090114;GO:0046903;GO:0046907;GO:0050896;GO:0043412;GO:0043413;GO:0008150;GO:0018196;GO:0006954;GO:0070271;GO:0001775;GO:0044249;GO:0034645;GO:0043086;GO:0044699;GO:0036211;GO:0051246;GO:0051640;GO:0006508;GO:0032501;GO:1902591;GO:0050878;GO:0043687;GO:0009987;GO:0009058;GO:0032269;GO:1901137;GO:1901135;GO:0032940;GO:0045861;GO:0048208;GO:0043933;GO:0031324;GO:0031323;GO:0048207;GO:0071822;GO:0006487;GO:0009100;GO:0002576;GO:0009101;GO:0071704;GO:0018279;GO:0048193;GO:0052548;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0044765;GO:0009059;GO:0044763;GO:0051648;GO:0051649;GO:0010951;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0006486;GO:0050790;GO:0044237;GO:1902589;GO:0044085;GO:0052547;GO:1902582;GO:1902580;GO:0048523; hemostasis;regulation of metabolic process;blood coagulation;vesicle coating;membrane budding;membrane organization;organic substance biosynthetic process;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;regulation of primary metabolic process;single-organism metabolic process;response to wounding;peptidyl-amino acid modification;negative regulation of peptidase activity;negative regulation of molecular function;negative regulation of biological process;negative regulation of macromolecule metabolic process;regulation of macromolecule metabolic process;regulation of cellular protein metabolic process;regulation of proteolysis;vesicle targeting;localization within membrane;platelet activation;vesicle-mediated transport;single-multicellular organism process;vesicle organization;regulation of biological process;protein metabolic process;cellular component assembly;negative regulation of metabolic process;macromolecule metabolic process;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;negative regulation of hydrolase activity;cellular macromolecule metabolic process;exocytosis;cellular component organization;regulated exocytosis;macromolecular complex assembly;biological regulation;regulation of molecular function;regulation of biological quality;transport;negative regulation of protein metabolic process;wound healing;regulation of cellular process;defense response;acute-phase response;response to stress;coagulation;single-organism membrane organization;metabolic process;single-organism carbohydrate metabolic process;acute inflammatory response;establishment of localization;regulation of hydrolase activity;COPII-coated vesicle budding;secretion;intracellular transport;response to stimulus;macromolecule modification;macromolecule glycosylation;biological_process;peptidyl-asparagine modification;inflammatory response;protein complex biogenesis;cell activation;cellular biosynthetic process;cellular macromolecule biosynthetic process;negative regulation of catalytic activity;single-organism process;protein modification process;regulation of protein metabolic process;organelle localization;proteolysis;multicellular organismal process;single-organism membrane budding;regulation of body fluid levels;post-translational protein modification;cellular process;biosynthetic process;negative regulation of cellular protein metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;secretion by cell;negative regulation of proteolysis;COPII vesicle coating;macromolecular complex subunit organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;vesicle targeting, rough ER to cis-Golgi;protein complex subunit organization;protein N-linked glycosylation;glycoprotein metabolic process;platelet degranulation;glycoprotein biosynthetic process;organic substance metabolic process;protein N-linked glycosylation via asparagine;Golgi vesicle transport;regulation of endopeptidase activity;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;vesicle localization;establishment of localization in cell;negative regulation of endopeptidase activity;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;protein glycosylation;regulation of catalytic activity;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;regulation of peptidase activity;single-organism intracellular transport;single-organism cellular localization;negative regulation of cellular process; 5;3;5;6;5;4;4;4;5;2;4;3;4;7;7;4;2;4;4;5;6;4;4;5;5;3;5;2;4;4;3;4;5;7;6;4;5;3;6;5;2;3;3;4;5;5;3;4;7;3;4;4;2;4;6;3;5;5;5;5;2;5;6;1;8;5;4;4;4;5;5;2;5;5;4;5;2;5;4;7;2;3;5;5;4;4;6;6;4;4;4;6;5;5;5;7;6;3;6;6;7;5;5;5;6;4;5;3;5;4;8;2;3;3;4;3;4;4;4;3;4;3;6;5;4;3; GO:0005783;GO:0031974;GO:0044433;GO:0031983;GO:0031982;GO:0016023;GO:0005615;GO:0016020;GO:0031988;GO:0005794;GO:0005793;GO:0098588;GO:0034774;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0030141;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0097708;GO:0005788;GO:0033116;GO:0031012;GO:0060205;GO:0005737;GO:0031091;GO:0031090;GO:0031093;GO:0031410;GO:0099503;GO:0044464;GO:0005623;GO:0005622;GO:0030133;GO:0030135;GO:0030134;GO:0070062;GO:0005576;GO:1903561;GO:0005575;GO:0070013;GO:0005578; endoplasmic reticulum;membrane-enclosed lumen;cytoplasmic vesicle part;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;extracellular space;membrane;membrane-bounded vesicle;Golgi apparatus;endoplasmic reticulum-Golgi intermediate compartment;bounding membrane of organelle;secretory granule lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;secretory granule;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intracellular vesicle;endoplasmic reticulum lumen;endoplasmic reticulum-Golgi intermediate compartment membrane;extracellular matrix;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;organelle membrane;platelet alpha granule lumen;cytoplasmic vesicle;secretory vesicle;cell part;cell;intracellular;transport vesicle;coated vesicle;ER to Golgi transport vesicle;extracellular exosome;extracellular region;extracellular vesicle;cellular_component;intracellular organelle lumen;proteinaceous extracellular matrix; 4;2;4;4;4;5;3;2;5;4;5;4;5;3;4;3;3;2;2;3;3;2;4;4;4;3;5;3;4;4;5;5;2;5;4;5;3;6;5;6;2;2;3;4;6;5;4;2;3;1;4;3; GO:0030414;GO:0097367;GO:0003674;GO:0005488;GO:0098772;GO:0061135;GO:0001948;GO:0061134;GO:0019899;GO:0004857;GO:0002020;GO:0042802;GO:0004866;GO:0004867;GO:0005515;GO:0030234; peptidase inhibitor activity;carbohydrate derivative binding;molecular_function;binding;molecular function regulator;endopeptidase regulator activity;glycoprotein binding;peptidase regulator activity;enzyme binding;enzyme inhibitor activity;protease binding;identical protein binding;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;protein binding;enzyme regulator activity; 5;3;1;2;2;5;4;4;4;4;5;4;6;7;3;3; K03984 map04610; Complement and coagulation cascades; IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; extracellular Hs21361198 856.0 V [V] Defense mechanisms; P02751 Fibronectin OS=Homo sapiens OX=9606 GN=FN1 PE=1 SV=4 - [FINC_HUMAN] 0.934 1.007 1.054 0.996 1.085 1 0.927507448 3.30E-12 0.91797235 2.62E-10 1.046673287 8.64E-21 0.921658986 0.007352844 GO:0007599;GO:0051046;GO:0051048;GO:0051049;GO:0007596;GO:0051716;GO:0048589;GO:0043207;GO:0000165;GO:0006979;GO:0034694;GO:0034695;GO:1990138;GO:0048583;GO:0008361;GO:0008360;GO:0071559;GO:0042325;GO:0009607;GO:0009605;GO:0034284;GO:0019538;GO:0018149;GO:0009893;GO:0000302;GO:0031175;GO:0035556;GO:0051223;GO:0051224;GO:0050789;GO:0000904;GO:0000902;GO:0071560;GO:0006887;GO:0070201;GO:0098602;GO:0009306;GO:0043412;GO:0002526;GO:0050710;GO:0071345;GO:0071347;GO:0048812;GO:0048545;GO:0048639;GO:0048638;GO:0007492;GO:0071248;GO:0048146;GO:0048145;GO:0048144;GO:0071241;GO:0051128;GO:0014070;GO:0060284;GO:0008284;GO:0050878;GO:0008283;GO:0001558;GO:0007409;GO:0034329;GO:0045927;GO:0060341;GO:0030030;GO:1990267;GO:0042592;GO:0042593;GO:0050900;GO:0008219;GO:0007275;GO:0033993;GO:0043067;GO:0043066;GO:0046689;GO:0043069;GO:0048598;GO:0006468;GO:2001202;GO:0006461;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:0051272;GO:0051270;GO:0048858;GO:0040017;GO:0048856;GO:0006796;GO:2000026;GO:0006793;GO:0048523;GO:0048522;GO:0048675;GO:0008104;GO:0034446;GO:0007160;GO:0007161;GO:0038044;GO:0031344;GO:0031346;GO:0044710;GO:0045785;GO:0070848;GO:0045664;GO:0045666;GO:0071331;GO:0071333;GO:0033036;GO:0006931;GO:0006935;GO:0010038;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:2001201;GO:0010628;GO:0044267;GO:0010646;GO:0044260;GO:0001568;GO:1904237;GO:1904235;GO:0043408;GO:0050793;GO:0009888;GO:0050794;GO:0051239;GO:0051234;GO:0035987;GO:0036119;GO:0050896;GO:0051962;GO:0051960;GO:2000145;GO:2000147;GO:0032103;GO:0032101;GO:0051246;GO:0007044;GO:1903531;GO:1903530;GO:0070887;GO:0044699;GO:0032880;GO:0050767;GO:0071379;GO:0051240;GO:0051241;GO:0001944;GO:0050769;GO:0010769;GO:0031399;GO:0040011;GO:0071398;GO:1901701;GO:0071396;GO:0040012;GO:0022617;GO:0002237;GO:0070372;GO:0070371;GO:0051384;GO:0043933;GO:0034330;GO:0001525;GO:0033622;GO:0030182;GO:0010810;GO:0010811;GO:0022411;GO:0042221;GO:0022008;GO:0008347;GO:0009746;GO:0044238;GO:0009743;GO:0044237;GO:0009749;GO:0010193;GO:0019220;GO:0019222;GO:0048588;GO:0048584;GO:0048468;GO:0072359;GO:0072358;GO:0060548;GO:0090066;GO:0071840;GO:0009966;GO:0048869;GO:0048514;GO:0010720;GO:0048518;GO:0048519;GO:0042127;GO:0031589;GO:0045184;GO:0002931;GO:0044700;GO:0016192;GO:0044707;GO:0071288;GO:0071322;GO:0071326;GO:0002376;GO:0007154;GO:0035924;GO:0032535;GO:0007165;GO:0022604;GO:0022607;GO:0022603;GO:0006929;GO:0006928;GO:0051674;GO:0043170;GO:0042981;GO:0045055;GO:0071219;GO:0071216;GO:0016477;GO:0048646;GO:0061564;GO:0034097;GO:0006810;GO:0006952;GO:0006953;GO:0006950;GO:0050817;GO:0001678;GO:0048731;GO:1902531;GO:0046903;GO:0012501;GO:0001775;GO:0040008;GO:0007369;GO:0006954;GO:0030155;GO:0030154;GO:1904950;GO:0001706;GO:0001704;GO:0036120;GO:0060560;GO:0071495;GO:0032501;GO:0009987;GO:0032870;GO:0032879;GO:0071363;GO:0050770;GO:0050772;GO:0070542;GO:0001816;GO:0001817;GO:0010770;GO:0001818;GO:0071222;GO:0071380;GO:0071229;GO:0051051;GO:0002576;GO:0032989;GO:0071704;GO:0071310;GO:0071702;GO:0030335;GO:0030334;GO:0006915;GO:0051174;GO:0051179;GO:1902578;GO:0051641;GO:1901654;GO:1901655;GO:0070555;GO:0080090;GO:0050920;GO:0050921;GO:0061387;GO:0023014;GO:0010604;GO:0042330;GO:0009617;GO:0009611;GO:0019725;GO:0043062;GO:0060255;GO:0031960;GO:0010976;GO:0010975;GO:0030516;GO:0030168;GO:0048870;GO:0048878;GO:0030198;GO:0048667;GO:0032940;GO:0032496;GO:0050708;GO:0050709;GO:0050707;GO:0016043;GO:0070271;GO:0065003;GO:0065007;GO:0065008;GO:0051130;GO:0009719;GO:0042063;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0071772;GO:0071773;GO:0016310;GO:0009790;GO:0023052;GO:0023051;GO:0009653;GO:0022610;GO:0045597;GO:0045595;GO:0001101;GO:0055082;GO:0032990;GO:0032268;GO:0051094;GO:0009725;GO:0032502;GO:0031323;GO:0010941;GO:0050663;GO:0040007;GO:0071822;GO:0033500;GO:0010467;GO:0044085;GO:0010468;GO:0048666;GO:0030307;GO:0007155;GO:0016049;GO:0048699;GO:0007399;GO:0045773;GO:0015031;GO:0001932; hemostasis;regulation of secretion;negative regulation of secretion;regulation of transport;blood coagulation;cellular response to stimulus;developmental growth;response to external biotic stimulus;MAPK cascade;response to oxidative stress;response to prostaglandin;response to prostaglandin E;neuron projection extension;regulation of response to stimulus;regulation of cell size;regulation of cell shape;response to transforming growth factor beta;regulation of phosphorylation;response to biotic stimulus;response to external stimulus;response to monosaccharide;protein metabolic process;peptide cross-linking;positive regulation of metabolic process;response to reactive oxygen species;neuron projection development;intracellular signal transduction;regulation of protein transport;negative regulation of protein transport;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular response to transforming growth factor beta stimulus;exocytosis;regulation of establishment of protein localization;single organism cell adhesion;protein secretion;macromolecule modification;acute inflammatory response;negative regulation of cytokine secretion;cellular response to cytokine stimulus;cellular response to interleukin-1;neuron projection morphogenesis;response to steroid hormone;positive regulation of developmental growth;regulation of developmental growth;endoderm development;cellular response to metal ion;positive regulation of fibroblast proliferation;regulation of fibroblast proliferation;fibroblast proliferation;cellular response to inorganic substance;regulation of cellular component organization;response to organic cyclic compound;regulation of cell development;positive regulation of cell proliferation;regulation of body fluid levels;cell proliferation;regulation of cell growth;axonogenesis;cell junction assembly;positive regulation of growth;regulation of cellular localization;cell projection organization;response to transition metal nanoparticle;homeostatic process;glucose homeostasis;leukocyte migration;cell death;multicellular organism development;response to lipid;regulation of programmed cell death;negative regulation of apoptotic process;response to mercury ion;negative regulation of programmed cell death;embryonic morphogenesis;protein phosphorylation;negative regulation of transforming growth factor-beta secretion;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;positive regulation of cellular component movement;regulation of cellular component movement;cell projection morphogenesis;positive regulation of locomotion;anatomical structure development;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;axon extension;protein localization;substrate adhesion-dependent cell spreading;cell-matrix adhesion;calcium-independent cell-matrix adhesion;transforming growth factor-beta secretion;regulation of cell projection organization;positive regulation of cell projection organization;single-organism metabolic process;positive regulation of cell adhesion;response to growth factor;regulation of neuron differentiation;positive regulation of neuron differentiation;cellular response to hexose stimulus;cellular response to glucose stimulus;macromolecule localization;substrate-dependent cell migration, cell attachment to substrate;chemotaxis;response to metal ion;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;regulation of transforming growth factor-beta secretion;positive regulation of gene expression;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;blood vessel development;positive regulation of substrate-dependent cell migration, cell attachment to substrate;regulation of substrate-dependent cell migration, cell attachment to substrate;regulation of MAPK cascade;regulation of developmental process;tissue development;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;endodermal cell differentiation;response to platelet-derived growth factor;response to stimulus;positive regulation of nervous system development;regulation of nervous system development;regulation of cell motility;positive regulation of cell motility;positive regulation of response to external stimulus;regulation of response to external stimulus;regulation of protein metabolic process;cell-substrate junction assembly;negative regulation of secretion by cell;regulation of secretion by cell;cellular response to chemical stimulus;single-organism process;regulation of protein localization;regulation of neurogenesis;cellular response to prostaglandin stimulus;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;vasculature development;positive regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;locomotion;cellular response to fatty acid;cellular response to oxygen-containing compound;cellular response to lipid;regulation of locomotion;extracellular matrix disassembly;response to molecule of bacterial origin;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;response to glucocorticoid;macromolecular complex subunit organization;cell junction organization;angiogenesis;integrin activation;neuron differentiation;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;cellular component disassembly;response to chemical;neurogenesis;glial cell migration;response to hexose;primary metabolic process;response to carbohydrate;cellular metabolic process;response to glucose;response to ozone;regulation of phosphate metabolic process;regulation of metabolic process;developmental cell growth;positive regulation of response to stimulus;cell development;circulatory system development;cardiovascular system development;negative regulation of cell death;regulation of anatomical structure size;cellular component organization or biogenesis;regulation of signal transduction;cellular developmental process;blood vessel morphogenesis;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;establishment of protein localization;response to ischemia;single organism signaling;vesicle-mediated transport;single-multicellular organism process;cellular response to mercury ion;cellular response to carbohydrate stimulus;cellular response to monosaccharide stimulus;immune system process;cell communication;cellular response to vascular endothelial growth factor stimulus;regulation of cellular component size;signal transduction;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;substrate-dependent cell migration;movement of cell or subcellular component;localization of cell;macromolecule metabolic process;regulation of apoptotic process;regulated exocytosis;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;cell migration;anatomical structure formation involved in morphogenesis;axon development;response to cytokine;transport;defense response;acute-phase response;response to stress;coagulation;cellular glucose homeostasis;system development;regulation of intracellular signal transduction;secretion;programmed cell death;cell activation;regulation of growth;gastrulation;inflammatory response;regulation of cell adhesion;cell differentiation;negative regulation of establishment of protein localization;endoderm formation;formation of primary germ layer;cellular response to platelet-derived growth factor stimulus;developmental growth involved in morphogenesis;cellular response to endogenous stimulus;multicellular organismal process;cellular process;cellular response to hormone stimulus;regulation of localization;cellular response to growth factor stimulus;regulation of axonogenesis;positive regulation of axonogenesis;response to fatty acid;cytokine production;regulation of cytokine production;positive regulation of cell morphogenesis involved in differentiation;negative regulation of cytokine production;cellular response to lipopolysaccharide;cellular response to prostaglandin E stimulus;cellular response to acid chemical;negative regulation of transport;platelet degranulation;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;organic substance transport;positive regulation of cell migration;regulation of cell migration;apoptotic process;regulation of phosphorus metabolic process;localization;single-organism localization;cellular localization;response to ketone;cellular response to ketone;response to interleukin-1;regulation of primary metabolic process;regulation of chemotaxis;positive regulation of chemotaxis;regulation of extent of cell growth;signal transduction by protein phosphorylation;positive regulation of macromolecule metabolic process;taxis;response to bacterium;response to wounding;cellular homeostasis;extracellular structure organization;regulation of macromolecule metabolic process;response to corticosteroid;positive regulation of neuron projection development;regulation of neuron projection development;regulation of axon extension;platelet activation;cell motility;chemical homeostasis;extracellular matrix organization;cell morphogenesis involved in neuron differentiation;secretion by cell;response to lipopolysaccharide;regulation of protein secretion;negative regulation of protein secretion;regulation of cytokine secretion;cellular component organization;protein complex biogenesis;macromolecular complex assembly;biological regulation;regulation of biological quality;positive regulation of cellular component organization;response to endogenous stimulus;gliogenesis;wound healing;protein modification process;biological_process;metabolic process;response to BMP;cellular response to BMP stimulus;phosphorylation;embryo development;signaling;regulation of signaling;anatomical structure morphogenesis;biological adhesion;positive regulation of cell differentiation;regulation of cell differentiation;response to acid chemical;cellular chemical homeostasis;cell part morphogenesis;regulation of cellular protein metabolic process;positive regulation of developmental process;response to hormone;developmental process;regulation of cellular metabolic process;regulation of cell death;cytokine secretion;growth;protein complex subunit organization;carbohydrate homeostasis;gene expression;cellular component biogenesis;regulation of gene expression;neuron development;positive regulation of cell growth;cell adhesion;cell growth;generation of neurons;nervous system development;positive regulation of axon extension;protein transport;regulation of protein phosphorylation; 5;5;4;4;5;3;3;4;5;4;5;6;5;3;5;4;4;7;3;3;6;4;7;3;5;5;5;5;4;2;5;5;5;5;5;3;5;5;6;5;6;7;6;5;4;4;5;6;5;5;4;5;4;5;5;4;4;3;4;7;5;3;4;4;4;4;7;3;4;4;5;5;6;5;5;4;7;6;5;6;3;4;3;4;4;4;5;3;3;5;4;4;3;3;6;4;4;5;6;6;5;5;3;4;5;7;6;8;7;3;5;4;5;4;3;4;2;6;5;5;4;4;4;6;6;6;3;4;3;3;3;6;4;2;4;5;4;4;4;4;5;6;4;5;4;2;4;6;6;3;3;5;5;6;6;2;6;5;6;3;5;5;7;6;7;4;4;4;6;6;5;5;4;3;6;5;7;3;5;3;8;5;6;3;4;3;4;5;5;4;4;2;4;4;4;5;2;2;4;4;4;4;3;5;3;6;6;7;2;4;7;4;4;5;4;4;5;4;3;4;6;6;5;4;4;3;6;5;4;4;7;3;4;6;4;5;5;5;4;3;5;5;4;5;3;5;4;5;4;4;2;2;5;3;6;7;6;5;4;4;5;4;6;7;5;3;7;4;3;5;5;5;5;6;5;2;3;3;5;6;6;4;4;4;5;4;4;3;4;4;4;4;4;6;6;6;5;5;3;5;5;6;4;5;6;5;5;3;4;5;2;3;4;3;7;5;5;1;2;4;5;6;5;2;3;3;2;4;4;4;5;5;5;3;4;2;4;4;5;2;5;6;5;3;5;5;4;3;3;7;5;5;5;7; GO:0034774;GO:0044424;GO:0044425;GO:0044420;GO:0044421;GO:0044422;GO:0045177;GO:0016324;GO:0044464;GO:0071944;GO:0070062;GO:0005615;GO:0016023;GO:0016020;GO:0099503;GO:0098589;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0072562;GO:0044433;GO:0030141;GO:0060205;GO:0031091;GO:0031093;GO:0043227;GO:0005605;GO:0005604;GO:0031974;GO:0098590;GO:0043229;GO:0043226;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0031012;GO:0005737;GO:0031983;GO:0031988;GO:0005793;GO:0097708;GO:0031410;GO:0044459;GO:0005623;GO:0005622;GO:0098805;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005577;GO:0005576;GO:0005578; secretory granule lumen;intracellular part;membrane part;extracellular matrix component;extracellular region part;organelle part;apical part of cell;apical plasma membrane;cell part;cell periphery;extracellular exosome;extracellular space;cytoplasmic, membrane-bounded vesicle;membrane;secretory vesicle;membrane region;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;blood microparticle;cytoplasmic vesicle part;secretory granule;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;platelet alpha granule lumen;membrane-bounded organelle;basal lamina;basement membrane;membrane-enclosed lumen;plasma membrane region;intracellular organelle;organelle;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;extracellular matrix;cytoplasm;vesicle lumen;membrane-bounded vesicle;endoplasmic reticulum-Golgi intermediate compartment;intracellular vesicle;cytoplasmic vesicle;plasma membrane part;cell;intracellular;whole membrane;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;fibrinogen complex;extracellular region;proteinaceous extracellular matrix; 5;3;2;2;2;2;3;4;2;3;4;3;5;2;6;3;3;3;4;3;3;4;4;5;5;6;3;3;3;2;4;3;2;3;4;3;4;2;4;4;5;5;4;5;3;2;3;3;3;3;2;1;3;2;3; GO:0098772;GO:0050839;GO:0005488;GO:1901681;GO:0019899;GO:0002020;GO:0032403;GO:0005515;GO:0044877;GO:0005102;GO:0005518;GO:0008047;GO:0061134;GO:0046872;GO:0003674;GO:0043169;GO:0045340;GO:0043167;GO:0042802;GO:0030234;GO:0016504;GO:0097367;GO:0005539;GO:0008201;GO:0005178;GO:0046914;GO:0043168; molecular function regulator;cell adhesion molecule binding;binding;sulfur compound binding;enzyme binding;protease binding;protein complex binding;protein binding;macromolecular complex binding;receptor binding;collagen binding;enzyme activator activity;peptidase regulator activity;metal ion binding;molecular_function;cation binding;mercury ion binding;ion binding;identical protein binding;enzyme regulator activity;peptidase activator activity;carbohydrate derivative binding;glycosaminoglycan binding;heparin binding;integrin binding;transition metal ion binding;anion binding; 2;4;2;3;4;5;4;3;3;4;5;4;4;5;1;4;7;3;4;3;5;3;4;4;5;6;4; K05717 map04151;map04510;map04512;map04810;map04933;map05100;map05146;map05200;map05205;map05222; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Regulation of actin cytoskeleton;AGE-RAGE signaling pathway in diabetic complications;Bacterial invasion of epithelial cells;Amoebiasis;Pathways in cancer;Proteoglycans in cancer;Small cell lung cancer; IPR013806;IPR000083;IPR013783;IPR000562;IPR003961; Kringle-like fold;Fibronectin, type I;Immunoglobulin-like fold;Fibronectin, type II, collagen-binding;Fibronectin type III; extracellular 430748271 73.6 X [X] Mobilome: prophages, transposons; COG4733 Phage-related protein, tail component A0A075B6R2 Immunoglobulin heavy variable 4-4 OS=Homo sapiens OX=9606 GN=IGHV4-4 PE=3 SV=2 - [HV404_HUMAN] 1.236 0.699 1.31 1.096 0.601 1.43 1.768240343 0.085705719 1.823627288 0.034829945 1.874105866 0.125027351 2.37936772 0.085327578 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P02753 Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3 - [RET4_HUMAN] 1.114 1.028 0.883 1.069 1.02 1.158 1.083657588 2.02E-06 1.048039216 0.012002847 0.858949416 0.268436107 1.135294118 2.94E-05 GO:0090087;GO:0032024;GO:0008104;GO:0051046;GO:0051047;GO:0051049;GO:0001501;GO:0072359;GO:0072358;GO:0044281;GO:0035265;GO:0061384;GO:0001894;GO:0061383;GO:0042445;GO:0007517;GO:0044711;GO:0048589;GO:0060249;GO:0055021;GO:0046879;GO:0048513;GO:0016101;GO:0009314;GO:0048518;GO:0048519;GO:0033036;GO:0060541;GO:0016202;GO:0006766;GO:0051050;GO:0007601;GO:0007600;GO:0007603;GO:0007602;GO:0003007;GO:0003006;GO:0090276;GO:0090277;GO:0010876;GO:0009628;GO:0010033;GO:0003008;GO:0044700;GO:0044702;GO:0051716;GO:0044707;GO:0060157;GO:0048878;GO:0002376;GO:0002377;GO:0033002;GO:0009792;GO:0009416;GO:0002702;GO:0044710;GO:0045843;GO:0048562;GO:0022600;GO:0015850;GO:0048568;GO:0023051;GO:0009887;GO:0051023;GO:0032940;GO:0048706;GO:0051024;GO:0060065;GO:0006775;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0030073;GO:0003205;GO:1901576;GO:0045471;GO:0003206;GO:0050708;GO:0010646;GO:0060419;GO:0050793;GO:0002684;GO:0065007;GO:0048807;GO:0048640;GO:0065008;GO:0072001;GO:0048592;GO:0048646;GO:1901861;GO:0070201;GO:1901862;GO:0006629;GO:0034633;GO:0009306;GO:0019318;GO:0055024;GO:0006810;GO:0055022;GO:0050796;GO:0050953;GO:0050794;GO:0060068;GO:0008150;GO:0030277;GO:0051239;GO:0044723;GO:0034308;GO:0051234;GO:0044238;GO:0050877;GO:0000003;GO:0002700;GO:0046903;GO:0051606;GO:0007423;GO:0050714;GO:0050896;GO:0009058;GO:0002697;GO:0048806;GO:0044283;GO:0002699;GO:1901615;GO:0055017;GO:0097305;GO:0048305;GO:0008152;GO:0001655;GO:0006869;GO:0030540;GO:0048635;GO:0048634;GO:0060044;GO:0023056;GO:0009790;GO:0015833;GO:0030323;GO:0023052;GO:1903530;GO:0060042;GO:1903532;GO:0061061;GO:0030324;GO:0010647;GO:0009653;GO:0044699;GO:0032880;GO:0006721;GO:0042886;GO:0007586;GO:0046660;GO:0051241;GO:0048638;GO:0043010;GO:0034754;GO:0042572;GO:0032502;GO:0008285;GO:0060420;GO:0032501;GO:0048608;GO:0008283;GO:0045184;GO:0006720;GO:0009987;GO:0007548;GO:0002637;GO:0061117;GO:0046883;GO:0002440;GO:0001101;GO:0046887;GO:1904951;GO:0044255;GO:0032879;GO:0055026;GO:0043009;GO:0002639;GO:0051093;GO:0042221;GO:0005996;GO:0048871;GO:0048738;GO:0048731;GO:0006006;GO:0060347;GO:0042127;GO:0002793;GO:0060343;GO:0060341;GO:0061458;GO:0046364;GO:0060043;GO:0007165;GO:0060059;GO:0042592;GO:0042593;GO:0014706;GO:0007275;GO:0048593;GO:0006094;GO:0009888;GO:0002682;GO:0060041;GO:0040007;GO:0033993;GO:0040008;GO:0016051;GO:0033500;GO:0001523;GO:0071705;GO:0071704;GO:0010669;GO:0048729;GO:0071702;GO:0009605;GO:0090596;GO:0048598;GO:0009581;GO:0032526;GO:0009583;GO:0009584;GO:0060038;GO:0009582;GO:0046620;GO:0046621;GO:0045926;GO:0002252;GO:0023061;GO:0010817;GO:0044767;GO:0022414;GO:0044765;GO:0044763;GO:0035112;GO:0007267;GO:0007154;GO:0035295;GO:0051179;GO:1902578;GO:0051641;GO:1901700;GO:0007507;GO:0019319;GO:0005975;GO:0002790;GO:0002791;GO:0048856;GO:0044237;GO:0009914;GO:0006066;GO:2000026;GO:0046864;GO:0060537;GO:0015031;GO:0001654;GO:0046865;GO:0014855;GO:0048523;GO:0048522; regulation of peptide transport;positive regulation of insulin secretion;protein localization;regulation of secretion;positive regulation of secretion;regulation of transport;skeletal system development;circulatory system development;cardiovascular system development;small molecule metabolic process;organ growth;heart trabecula morphogenesis;tissue homeostasis;trabecula morphogenesis;hormone metabolic process;muscle organ development;single-organism biosynthetic process;developmental growth;anatomical structure homeostasis;regulation of cardiac muscle tissue growth;hormone secretion;animal organ development;diterpenoid metabolic process;response to radiation;positive regulation of biological process;negative regulation of biological process;macromolecule localization;respiratory system development;regulation of striated muscle tissue development;vitamin metabolic process;positive regulation of transport;visual perception;sensory perception;phototransduction, visible light;phototransduction;heart morphogenesis;developmental process involved in reproduction;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;lipid localization;response to abiotic stimulus;response to organic substance;system process;single organism signaling;single organism reproductive process;cellular response to stimulus;single-multicellular organism process;urinary bladder development;chemical homeostasis;immune system process;immunoglobulin production;muscle cell proliferation;embryo development ending in birth or egg hatching;response to light stimulus;positive regulation of production of molecular mediator of immune response;single-organism metabolic process;negative regulation of striated muscle tissue development;embryonic organ morphogenesis;digestive system process;organic hydroxy compound transport;embryonic organ development;regulation of signaling;organ morphogenesis;regulation of immunoglobulin secretion;secretion by cell;embryonic skeletal system development;positive regulation of immunoglobulin secretion;uterus development;fat-soluble vitamin metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;cardiac chamber development;organic substance biosynthetic process;response to ethanol;cardiac chamber morphogenesis;regulation of protein secretion;regulation of cell communication;heart growth;regulation of developmental process;positive regulation of immune system process;biological regulation;female genitalia morphogenesis;negative regulation of developmental growth;regulation of biological quality;renal system development;eye morphogenesis;anatomical structure formation involved in morphogenesis;regulation of muscle tissue development;regulation of establishment of protein localization;negative regulation of muscle tissue development;lipid metabolic process;retinol transport;protein secretion;hexose metabolic process;regulation of cardiac muscle tissue development;transport;negative regulation of cardiac muscle tissue growth;regulation of insulin secretion;sensory perception of light stimulus;regulation of cellular process;vagina development;biological_process;maintenance of gastrointestinal epithelium;regulation of multicellular organismal process;single-organism carbohydrate metabolic process;primary alcohol metabolic process;establishment of localization;primary metabolic process;neurological system process;reproduction;regulation of production of molecular mediator of immune response;secretion;detection of stimulus;sensory organ development;positive regulation of protein secretion;response to stimulus;biosynthetic process;regulation of immune effector process;genitalia development;small molecule biosynthetic process;positive regulation of immune effector process;organic hydroxy compound metabolic process;cardiac muscle tissue growth;response to alcohol;immunoglobulin secretion;metabolic process;urogenital system development;lipid transport;female genitalia development;negative regulation of muscle organ development;regulation of muscle organ development;negative regulation of cardiac muscle cell proliferation;positive regulation of signaling;embryo development;peptide transport;respiratory tube development;signaling;regulation of secretion by cell;retina morphogenesis in camera-type eye;positive regulation of secretion by cell;muscle structure development;lung development;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;regulation of protein localization;terpenoid metabolic process;amide transport;digestion;female sex differentiation;negative regulation of multicellular organismal process;regulation of developmental growth;camera-type eye development;cellular hormone metabolic process;retinol metabolic process;developmental process;negative regulation of cell proliferation;regulation of heart growth;multicellular organismal process;reproductive structure development;cell proliferation;establishment of protein localization;isoprenoid metabolic process;cellular process;sex differentiation;regulation of immunoglobulin production;negative regulation of heart growth;regulation of hormone secretion;production of molecular mediator of immune response;response to acid chemical;positive regulation of hormone secretion;positive regulation of establishment of protein localization;cellular lipid metabolic process;regulation of localization;negative regulation of cardiac muscle tissue development;chordate embryonic development;positive regulation of immunoglobulin production;negative regulation of developmental process;response to chemical;monosaccharide metabolic process;multicellular organismal homeostasis;cardiac muscle tissue development;system development;glucose metabolic process;heart trabecula formation;regulation of cell proliferation;positive regulation of peptide secretion;trabecula formation;regulation of cellular localization;reproductive system development;monosaccharide biosynthetic process;regulation of cardiac muscle cell proliferation;signal transduction;embryonic retina morphogenesis in camera-type eye;homeostatic process;glucose homeostasis;striated muscle tissue development;multicellular organism development;camera-type eye morphogenesis;gluconeogenesis;tissue development;regulation of immune system process;retina development in camera-type eye;growth;response to lipid;regulation of growth;carbohydrate biosynthetic process;carbohydrate homeostasis;retinoid metabolic process;nitrogen compound transport;organic substance metabolic process;epithelial structure maintenance;tissue morphogenesis;organic substance transport;response to external stimulus;sensory organ morphogenesis;embryonic morphogenesis;detection of external stimulus;response to retinoic acid;detection of light stimulus;detection of visible light;cardiac muscle cell proliferation;detection of abiotic stimulus;regulation of organ growth;negative regulation of organ growth;negative regulation of growth;immune effector process;signal release;regulation of hormone levels;single-organism developmental process;reproductive process;single-organism transport;single-organism cellular process;genitalia morphogenesis;cell-cell signaling;cell communication;tube development;localization;single-organism localization;cellular localization;response to oxygen-containing compound;heart development;hexose biosynthetic process;carbohydrate metabolic process;peptide secretion;regulation of peptide secretion;anatomical structure development;cellular metabolic process;hormone transport;alcohol metabolic process;regulation of multicellular organismal development;isoprenoid transport;muscle tissue development;protein transport;eye development;terpenoid transport;striated muscle cell proliferation;negative regulation of cellular process;positive regulation of cellular process; 5;6;4;5;4;4;5;5;5;4;4;5;5;4;3;5;4;3;5;5;6;4;7;4;2;2;3;5;5;5;3;7;5;6;5;5;3;5;5;4;3;4;3;3;3;3;3;4;5;2;4;4;6;5;4;3;5;5;4;5;4;3;4;6;4;6;6;4;6;4;5;2;7;6;4;4;6;4;6;4;5;3;3;2;5;4;3;5;6;3;4;5;4;4;6;5;6;6;4;5;6;6;3;6;1;5;3;4;6;3;3;4;2;4;5;3;4;5;2;3;4;4;5;4;4;4;5;5;2;5;5;5;4;5;5;3;5;6;4;2;5;5;4;4;4;4;3;2;4;6;5;4;5;3;4;6;4;5;2;4;5;2;4;3;4;5;2;4;5;5;4;3;4;4;3;4;3;6;7;5;3;3;5;4;5;4;7;5;4;5;4;4;5;6;5;4;5;4;7;6;4;7;8;4;3;4;2;5;3;5;6;8;5;3;6;4;5;3;5;4;4;5;5;6;5;4;4;4;3;3;5;4;3;2;4;3;4;4;4;4;2;3;3;4;4;7;4;6;6;3;3;5;5;4;6;5;5;5;7;5;3;3; GO:0005615;GO:0043234;GO:0043230;GO:0005829;GO:0044424;GO:0044421;GO:0043227;GO:0005737;GO:0044444;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070062;GO:0031982;GO:1903561;GO:0005576;GO:0043226; extracellular space;protein complex;extracellular organelle;cytosol;intracellular part;extracellular region part;membrane-bounded organelle;cytoplasm;cytoplasmic part;macromolecular complex;cell part;cell;intracellular;cellular_component;extracellular exosome;vesicle;extracellular vesicle;extracellular region;organelle; 3;3;3;5;3;2;3;4;4;2;2;2;3;1;4;4;3;2;2; GO:0008289;GO:0005215;GO:0016918;GO:0005319;GO:0003674;GO:0005488;GO:0051183;GO:0036094;GO:0022892;GO:0034632;GO:0005501;GO:0043178;GO:0019842;GO:0019840;GO:0019841; lipid binding;transporter activity;retinal binding;lipid transporter activity;molecular_function;binding;vitamin transporter activity;small molecule binding;substrate-specific transporter activity;retinol transporter activity;retinoid binding;alcohol binding;vitamin binding;isoprenoid binding;retinol binding; 3;2;5;4;1;2;3;3;3;4;5;4;4;4;5; K18271 IPR002345;IPR002449;IPR000566;IPR022271;IPR012674;IPR022272; Lipocalin;Retinol binding protein/Purpurin;Lipocalin/cytosolic fatty-acid binding domain;Lipocalin, ApoD type;Calycin;Lipocalin family conserved site; extracellular P08709 Coagulation factor VII OS=Homo sapiens OX=9606 GN=F7 PE=1 SV=1 - [FA7_HUMAN] 1.143 0.955 0.895 1.327 0.872 1.252 1.196858639 nan 1.521788991 nan 0.937172775 nan 1.435779817 nan GO:0007599;GO:0007598;GO:0007596;GO:0048583;GO:0050926;GO:0050927;GO:0050920;GO:0050921;GO:0007166;GO:0007167;GO:0007169;GO:0051897;GO:0044707;GO:0044710;GO:0042330;GO:0002687;GO:0009966;GO:0009967;GO:0018214;GO:0009611;GO:0018193;GO:0048511;GO:0048513;GO:0048518;GO:0002682;GO:0030595;GO:0048584;GO:0006935;GO:0043434;GO:0010033;GO:0016192;GO:0044700;GO:0016477;GO:1901564;GO:0009605;GO:0019538;GO:0010243;GO:0048870;GO:0017187;GO:0018200;GO:0061041;GO:0050789;GO:0007154;GO:0007165;GO:0023051;GO:0006928;GO:0050820;GO:0051674;GO:0035556;GO:0043170;GO:0044267;GO:0006888;GO:0044260;GO:0051896;GO:0080134;GO:0002685;GO:0065007;GO:0014070;GO:0065008;GO:1900048;GO:0002688;GO:0007623;GO:0032571;GO:0006810;GO:0051716;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:1902533;GO:0051234;GO:0050818;GO:0046907;GO:0043491;GO:0050896;GO:0043412;GO:0060416;GO:0036211;GO:2000145;GO:0002690;GO:2000147;GO:0006518;GO:0030194;GO:0009719;GO:0032103;GO:0032101;GO:0030193;GO:0023056;GO:0034641;GO:0023052;GO:0070887;GO:0050918;GO:0060326;GO:0010647;GO:0010646;GO:0010641;GO:0010640;GO:0044699;GO:1902531;GO:0051240;GO:0031099;GO:0033273;GO:1902578;GO:0006508;GO:1903034;GO:1903036;GO:0032502;GO:1901700;GO:0032501;GO:0050878;GO:0051272;GO:0043687;GO:0009987;GO:0051270;GO:0016485;GO:0032879;GO:0051604;GO:0043603;GO:0002684;GO:0009725;GO:0048008;GO:0051239;GO:0006807;GO:0048731;GO:1901698;GO:0048545;GO:0009991;GO:1900046;GO:0002376;GO:0050900;GO:0090303;GO:0007275;GO:0031667;GO:0072376;GO:0072378;GO:0031100;GO:0071704;GO:0010467;GO:0030335;GO:0030334;GO:0048193;GO:0007584;GO:0006464;GO:0006465;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0043627;GO:0042221;GO:0051179;GO:0051641;GO:0040011;GO:0044238;GO:0040012;GO:0040017;GO:0048856;GO:0044237;GO:1901654;GO:1901652;GO:0033993;GO:1902582;GO:0048522; hemostasis;blood coagulation, extrinsic pathway;blood coagulation;regulation of response to stimulus;regulation of positive chemotaxis;positive regulation of positive chemotaxis;regulation of chemotaxis;positive regulation of chemotaxis;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of protein kinase B signaling;single-multicellular organism process;single-organism metabolic process;taxis;positive regulation of leukocyte migration;regulation of signal transduction;positive regulation of signal transduction;protein carboxylation;response to wounding;peptidyl-amino acid modification;rhythmic process;animal organ development;positive regulation of biological process;regulation of immune system process;leukocyte chemotaxis;positive regulation of response to stimulus;chemotaxis;response to peptide hormone;response to organic substance;vesicle-mediated transport;single organism signaling;cell migration;organonitrogen compound metabolic process;response to external stimulus;protein metabolic process;response to organonitrogen compound;cell motility;peptidyl-glutamic acid carboxylation;peptidyl-glutamic acid modification;regulation of wound healing;regulation of biological process;cell communication;signal transduction;regulation of signaling;movement of cell or subcellular component;positive regulation of coagulation;localization of cell;intracellular signal transduction;macromolecule metabolic process;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;regulation of protein kinase B signaling;regulation of response to stress;regulation of leukocyte migration;biological regulation;response to organic cyclic compound;regulation of biological quality;positive regulation of hemostasis;regulation of leukocyte chemotaxis;circadian rhythm;response to vitamin K;transport;cellular response to stimulus;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;positive regulation of intracellular signal transduction;establishment of localization;regulation of coagulation;intracellular transport;protein kinase B signaling;response to stimulus;macromolecule modification;response to growth hormone;protein modification process;regulation of cell motility;positive regulation of leukocyte chemotaxis;positive regulation of cell motility;peptide metabolic process;positive regulation of blood coagulation;response to endogenous stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;regulation of blood coagulation;positive regulation of signaling;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;positive chemotaxis;cell chemotaxis;positive regulation of cell communication;regulation of cell communication;positive regulation of platelet-derived growth factor receptor signaling pathway;regulation of platelet-derived growth factor receptor signaling pathway;single-organism process;regulation of intracellular signal transduction;positive regulation of multicellular organismal process;regeneration;response to vitamin;single-organism localization;proteolysis;regulation of response to wounding;positive regulation of response to wounding;developmental process;response to oxygen-containing compound;multicellular organismal process;regulation of body fluid levels;positive regulation of cellular component movement;post-translational protein modification;cellular process;regulation of cellular component movement;protein processing;regulation of localization;protein maturation;cellular amide metabolic process;positive regulation of immune system process;response to hormone;platelet-derived growth factor receptor signaling pathway;regulation of multicellular organismal process;nitrogen compound metabolic process;system development;response to nitrogen compound;response to steroid hormone;response to extracellular stimulus;regulation of hemostasis;immune system process;leukocyte migration;positive regulation of wound healing;multicellular organism development;response to nutrient levels;protein activation cascade;blood coagulation, fibrin clot formation;organ regeneration;organic substance metabolic process;gene expression;positive regulation of cell migration;regulation of cell migration;Golgi vesicle transport;response to nutrient;cellular protein modification process;signal peptide processing;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;response to estrogen;response to chemical;localization;cellular localization;locomotion;primary metabolic process;regulation of locomotion;positive regulation of locomotion;anatomical structure development;cellular metabolic process;response to ketone;response to peptide;response to lipid;single-organism intracellular transport;positive regulation of cellular process; 5;4;5;3;5;5;4;4;5;6;7;6;3;3;3;4;4;4;7;4;7;2;4;2;3;4;3;4;5;4;5;3;4;4;3;4;4;3;8;8;6;2;4;4;3;4;4;3;5;4;5;7;4;6;4;4;2;5;3;4;5;3;6;4;3;5;3;3;4;1;2;5;3;4;5;6;2;5;6;5;4;5;4;5;5;3;4;4;5;3;4;2;4;5;5;4;4;5;5;2;5;3;4;5;3;5;5;4;2;4;2;4;4;7;2;4;6;3;5;5;3;4;8;3;3;4;4;5;4;4;2;3;5;4;5;3;4;5;3;5;5;5;6;4;6;6;3;4;3;4;6;3;2;3;2;3;3;3;3;3;5;5;5;5;3; GO:0031974;GO:0005783;GO:0031982;GO:0016020;GO:0005794;GO:0005788;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0044431;GO:0071944;GO:0012505;GO:0044446;GO:0044444;GO:0005886;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005796;GO:0005615;GO:0043226;GO:0005576;GO:0005575;GO:0070013; membrane-enclosed lumen;endoplasmic reticulum;vesicle;membrane;Golgi apparatus;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;Golgi apparatus part;cell periphery;endomembrane system;intracellular organelle part;cytoplasmic part;plasma membrane;cytoplasm;cell part;cell;intracellular;Golgi lumen;extracellular space;organelle;extracellular region;cellular_component;intracellular organelle lumen; 2;4;4;2;4;5;4;3;3;2;2;3;3;4;4;3;3;3;4;3;4;2;2;3;5;3;2;2;1;4; GO:0004252;GO:0046872;GO:0017171;GO:0097367;GO:0003674;GO:0005488;GO:0008233;GO:0016787;GO:0003824;GO:0008236;GO:0043169;GO:0043167;GO:0005509;GO:0005515;GO:0004175;GO:0001948;GO:0070011; serine-type endopeptidase activity;metal ion binding;serine hydrolase activity;carbohydrate derivative binding;molecular_function;binding;peptidase activity;hydrolase activity;catalytic activity;serine-type peptidase activity;cation binding;ion binding;calcium ion binding;protein binding;endopeptidase activity;glycoprotein binding;peptidase activity, acting on L-amino acid peptides; 6;5;4;3;1;2;4;3;2;5;4;3;6;3;6;4;5; K01320 map04610; Complement and coagulation cascades; IPR000152;IPR018097;IPR001254;IPR000742;IPR017857;IPR033190;IPR009003;IPR000294;IPR001314;IPR001881;IPR013032;IPR033116;IPR018114; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;EGF-like domain;Coagulation factor, subgroup, Gla domain;Coagulation factor VII;Peptidase S1, PA clan;Gamma-carboxyglutamic acid-rich (GLA) domain;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular 159897046 187.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease P02750 Leucine-rich alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=LRG1 PE=1 SV=2 - [A2GL_HUMAN] 1.014 0.827 1.277 1.047 0.817 1.181 1.226118501 7.01E-12 1.281517748 3.52E-34 1.544135429 5.67E-30 1.445532436 5.59E-14 GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0007167;GO:0051716;GO:0009966;GO:0048869;GO:0070848;GO:0048514;GO:0030511;GO:0048518;GO:0042127;GO:0071363;GO:0010033;GO:0007179;GO:0007178;GO:0044700;GO:0044707;GO:0007154;GO:0022603;GO:1901342;GO:0010646;GO:0090100;GO:0001568;GO:0065007;GO:0048646;GO:0050793;GO:0017015;GO:0050794;GO:0008150;GO:0051239;GO:0050896;GO:0009967;GO:0030154;GO:0023056;GO:0023052;GO:0070887;GO:0023051;GO:0010647;GO:0009653;GO:0044699;GO:0009719;GO:0090287;GO:1904018;GO:0051240;GO:0001944;GO:0008284;GO:0032501;GO:0008283;GO:0009987;GO:0050873;GO:0050678;GO:0050679;GO:0051094;GO:0050673;GO:0071560;GO:0048731;GO:0032502;GO:0045444;GO:0001525;GO:0007275;GO:1903846;GO:0045765;GO:0045766;GO:0050789;GO:0071310;GO:2000026;GO:0071559;GO:0090092;GO:0044767;GO:0044763;GO:0042221;GO:1903844;GO:0048856;GO:0001938;GO:0071495;GO:0048522;GO:0001935;GO:0001936; positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;cellular response to stimulus;regulation of signal transduction;cellular developmental process;response to growth factor;blood vessel morphogenesis;positive regulation of transforming growth factor beta receptor signaling pathway;positive regulation of biological process;regulation of cell proliferation;cellular response to growth factor stimulus;response to organic substance;transforming growth factor beta receptor signaling pathway;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;single-multicellular organism process;cell communication;regulation of anatomical structure morphogenesis;regulation of vasculature development;regulation of cell communication;positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;blood vessel development;biological regulation;anatomical structure formation involved in morphogenesis;regulation of developmental process;regulation of transforming growth factor beta receptor signaling pathway;regulation of cellular process;biological_process;regulation of multicellular organismal process;response to stimulus;positive regulation of signal transduction;cell differentiation;positive regulation of signaling;signaling;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;response to endogenous stimulus;regulation of cellular response to growth factor stimulus;positive regulation of vasculature development;positive regulation of multicellular organismal process;vasculature development;positive regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;brown fat cell differentiation;regulation of epithelial cell proliferation;positive regulation of epithelial cell proliferation;positive regulation of developmental process;epithelial cell proliferation;cellular response to transforming growth factor beta stimulus;system development;developmental process;fat cell differentiation;angiogenesis;multicellular organism development;positive regulation of cellular response to transforming growth factor beta stimulus;regulation of angiogenesis;positive regulation of angiogenesis;regulation of biological process;cellular response to organic substance;regulation of multicellular organismal development;response to transforming growth factor beta;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;single-organism developmental process;single-organism cellular process;response to chemical;regulation of cellular response to transforming growth factor beta stimulus;anatomical structure development;positive regulation of endothelial cell proliferation;cellular response to endogenous stimulus;positive regulation of cellular process;endothelial cell proliferation;regulation of endothelial cell proliferation; 3;3;5;5;4;5;6;3;4;4;5;4;5;2;4;6;4;6;7;3;3;4;4;5;4;5;4;2;3;3;6;3;1;3;2;4;5;3;2;4;3;4;3;2;3;4;4;3;5;4;2;3;2;7;5;5;3;4;5;4;2;6;4;4;4;5;5;2;5;4;4;5;3;3;3;5;3;6;4;3;5;6; GO:0031982;GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0043226;GO:0005615;GO:0070062;GO:1903561;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;organelle;extracellular space;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;2;3;2;3;2;3;4;3;1;2; IPR003591;IPR032675;IPR000483;IPR001611; Leucine-rich repeat, typical subtype;Leucine-rich repeat domain, L domain-like;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat; extracellular Hs16418467 690.0 R [R] General function prediction only; P61769 Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1 - [B2MG_HUMAN] 1.051 0.879 1.164 0.955 0.813 1.882 1.195676906 0.03513526 1.174661747 0.000337809 1.324232082 0.000192764 2.314883149 0.00192076 GO:0051049;GO:0002706;GO:0002705;GO:0002703;GO:0002702;GO:0002700;GO:0098771;GO:0048260;GO:0002709;GO:0051716;GO:0043207;GO:0060249;GO:0048468;GO:0002824;GO:0002822;GO:0002821;GO:0050830;GO:0065008;GO:0009607;GO:0009605;GO:0019538;GO:0002369;GO:0006457;GO:0031175;GO:0050789;GO:0032091;GO:0032092;GO:0002684;GO:0002682;GO:0002708;GO:0019882;GO:0019883;GO:0019884;GO:0019885;GO:0033077;GO:0098609;GO:0002480;GO:0002481;GO:0002483;GO:0002521;GO:0002520;GO:0071345;GO:0071346;GO:0043393;GO:0071248;GO:0001775;GO:0071241;GO:0051129;GO:0051128;GO:0060284;GO:0098542;GO:0072511;GO:0030030;GO:1990267;GO:0042592;GO:0042590;GO:0007275;GO:0033993;GO:0051961;GO:0015684;GO:0046686;GO:0097286;GO:0045087;GO:0044767;GO:0060333;GO:0044765;GO:0044764;GO:0044763;GO:0030100;GO:1901700;GO:1901701;GO:0048856;GO:2000021;GO:2000026;GO:0048523;GO:0048522;GO:0007165;GO:0007166;GO:0031341;GO:0002456;GO:0031343;GO:0031345;GO:0031344;GO:0031347;GO:0045665;GO:0045664;GO:0001909;GO:0044093;GO:0044092;GO:0001906;GO:0044700;GO:0010038;GO:0010039;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:0002428;GO:0002831;GO:0045321;GO:0048002;GO:0001913;GO:0044260;GO:0070627;GO:0050793;GO:0050794;GO:0051239;GO:0051234;GO:0010959;GO:0006897;GO:0050896;GO:0006898;GO:0002697;GO:0051960;GO:0002699;GO:0032101;GO:0070887;GO:0044699;GO:0050767;GO:0051240;GO:0051241;GO:0050768;GO:0071396;GO:0043270;GO:0070838;GO:0002460;GO:0042493;GO:0002237;GO:0048731;GO:0016337;GO:1900390;GO:0002726;GO:0002720;GO:0030182;GO:0050690;GO:0034758;GO:0070489;GO:0055065;GO:0042221;GO:0022008;GO:0070486;GO:0034756;GO:0044238;GO:0097460;GO:0030217;GO:0044237;GO:0044403;GO:0045807;GO:0019221;GO:0019730;GO:0019731;GO:0048584;GO:0048583;GO:0032844;GO:0071840;GO:0048869;GO:0048513;GO:0010721;GO:0048518;GO:0048519;GO:0071281;GO:0016192;GO:0044707;GO:0002376;GO:0001912;GO:0001910;GO:0001916;GO:0001914;GO:0042391;GO:0051100;GO:0098602;GO:0099587;GO:1903991;GO:0071219;GO:0071216;GO:0034097;GO:0006812;GO:0006811;GO:0006810;GO:0006952;GO:0043900;GO:0006955;GO:0006959;GO:0051607;GO:0080134;GO:0006950;GO:0030154;GO:1903989;GO:0032502;GO:0032501;GO:0009987;GO:0060627;GO:0032879;GO:0050776;GO:0050778;GO:0003254;GO:0001816;GO:0001817;GO:0001819;GO:0071222;GO:0042110;GO:0002724;GO:0043269;GO:0002475;GO:0002474;GO:0002477;GO:0051050;GO:0002479;GO:0002478;GO:0071704;GO:0071310;GO:0034341;GO:0002711;GO:0042026;GO:0002718;GO:0051179;GO:1902578;GO:0050688;GO:0051899;GO:0055072;GO:0006826;GO:0055076;GO:0009615;GO:0009617;GO:0044419;GO:0046649;GO:0010977;GO:0010975;GO:0048871;GO:0048878;GO:0042742;GO:0032496;GO:0016043;GO:0002367;GO:0065007;GO:0065009;GO:0071593;GO:0071594;GO:0051130;GO:0008150;GO:0008152;GO:0048259;GO:1904435;GO:1904434;GO:1904437;GO:1904432;GO:0050801;GO:0002819;GO:0002440;GO:0023052;GO:0002443;GO:0000041;GO:0022610;GO:0045596;GO:0045595;GO:0030001;GO:0055080;GO:0001894;GO:0001895;GO:0051093;GO:0051099;GO:0051098;GO:0043170;GO:1900122;GO:1900121;GO:1900120;GO:0030098;GO:0030097;GO:0050829;GO:0097459;GO:0048534;GO:0048666;GO:0044267;GO:0002252;GO:0002449;GO:0007159;GO:0007155;GO:0007154;GO:0048699;GO:0007399;GO:0002250;GO:0016032;GO:0098659;GO:0098657; regulation of transport;regulation of lymphocyte mediated immunity;positive regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;positive regulation of production of molecular mediator of immune response;regulation of production of molecular mediator of immune response;inorganic ion homeostasis;positive regulation of receptor-mediated endocytosis;regulation of T cell mediated immunity;cellular response to stimulus;response to external biotic stimulus;anatomical structure homeostasis;cell development;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of adaptive immune response;defense response to Gram-positive bacterium;regulation of biological quality;response to biotic stimulus;response to external stimulus;protein metabolic process;T cell cytokine production;protein folding;neuron projection development;regulation of biological process;negative regulation of protein binding;positive regulation of protein binding;positive regulation of immune system process;regulation of immune system process;positive regulation of lymphocyte mediated immunity;antigen processing and presentation;antigen processing and presentation of endogenous antigen;antigen processing and presentation of exogenous antigen;antigen processing and presentation of endogenous peptide antigen via MHC class I;T cell differentiation in thymus;cell-cell adhesion;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent;antigen processing and presentation of endogenous peptide antigen;leukocyte differentiation;immune system development;cellular response to cytokine stimulus;cellular response to interferon-gamma;regulation of protein binding;cellular response to metal ion;cell activation;cellular response to inorganic substance;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cell development;defense response to other organism;divalent inorganic cation transport;cell projection organization;response to transition metal nanoparticle;homeostatic process;antigen processing and presentation of exogenous peptide antigen via MHC class I;multicellular organism development;response to lipid;negative regulation of nervous system development;ferrous iron transport;response to cadmium ion;iron ion import;innate immune response;single-organism developmental process;interferon-gamma-mediated signaling pathway;single-organism transport;multi-organism cellular process;single-organism cellular process;regulation of endocytosis;response to oxygen-containing compound;cellular response to oxygen-containing compound;anatomical structure development;regulation of ion homeostasis;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process;signal transduction;cell surface receptor signaling pathway;regulation of cell killing;T cell mediated immunity;positive regulation of cell killing;negative regulation of cell projection organization;regulation of cell projection organization;regulation of defense response;negative regulation of neuron differentiation;regulation of neuron differentiation;leukocyte mediated cytotoxicity;positive regulation of molecular function;negative regulation of molecular function;cell killing;single organism signaling;response to metal ion;response to iron ion;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;antigen processing and presentation of peptide antigen via MHC class Ib;regulation of response to biotic stimulus;leukocyte activation;antigen processing and presentation of peptide antigen;T cell mediated cytotoxicity;cellular macromolecule metabolic process;ferrous iron import;regulation of developmental process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of metal ion transport;endocytosis;response to stimulus;receptor-mediated endocytosis;regulation of immune effector process;regulation of nervous system development;positive regulation of immune effector process;regulation of response to external stimulus;cellular response to chemical stimulus;single-organism process;regulation of neurogenesis;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;negative regulation of neurogenesis;cellular response to lipid;positive regulation of ion transport;divalent metal ion transport;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;response to drug;response to molecule of bacterial origin;system development;single organismal cell-cell adhesion;regulation of iron ion import;positive regulation of T cell cytokine production;positive regulation of cytokine production involved in immune response;neuron differentiation;regulation of defense response to virus by virus;positive regulation of iron ion transport;T cell aggregation;metal ion homeostasis;response to chemical;neurogenesis;leukocyte aggregation;regulation of iron ion transport;primary metabolic process;ferrous iron import into cell;T cell differentiation;cellular metabolic process;symbiosis, encompassing mutualism through parasitism;positive regulation of endocytosis;cytokine-mediated signaling pathway;antimicrobial humoral response;antibacterial humoral response;positive regulation of response to stimulus;regulation of response to stimulus;regulation of homeostatic process;cellular component organization or biogenesis;cellular developmental process;animal organ development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;cellular response to iron ion;vesicle-mediated transport;single-multicellular organism process;immune system process;positive regulation of leukocyte mediated cytotoxicity;regulation of leukocyte mediated cytotoxicity;positive regulation of T cell mediated cytotoxicity;regulation of T cell mediated cytotoxicity;regulation of membrane potential;negative regulation of binding;single organism cell adhesion;inorganic ion import into cell;positive regulation of ferrous iron import into cell;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;response to cytokine;cation transport;ion transport;transport;defense response;regulation of multi-organism process;immune response;humoral immune response;defense response to virus;regulation of response to stress;response to stress;cell differentiation;regulation of ferrous iron import into cell;developmental process;multicellular organismal process;cellular process;regulation of vesicle-mediated transport;regulation of localization;regulation of immune response;positive regulation of immune response;regulation of membrane depolarization;cytokine production;regulation of cytokine production;positive regulation of cytokine production;cellular response to lipopolysaccharide;T cell activation;regulation of T cell cytokine production;regulation of ion transport;antigen processing and presentation via MHC class Ib;antigen processing and presentation of peptide antigen via MHC class I;antigen processing and presentation of exogenous peptide antigen via MHC class Ib;positive regulation of transport;antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;antigen processing and presentation of exogenous peptide antigen;organic substance metabolic process;cellular response to organic substance;response to interferon-gamma;positive regulation of T cell mediated immunity;protein refolding;regulation of cytokine production involved in immune response;localization;single-organism localization;regulation of defense response to virus;membrane depolarization;iron ion homeostasis;iron ion transport;transition metal ion homeostasis;response to virus;response to bacterium;interspecies interaction between organisms;lymphocyte activation;negative regulation of neuron projection development;regulation of neuron projection development;multicellular organismal homeostasis;chemical homeostasis;defense response to bacterium;response to lipopolysaccharide;cellular component organization;cytokine production involved in immune response;biological regulation;regulation of molecular function;lymphocyte aggregation;thymocyte aggregation;positive regulation of cellular component organization;biological_process;metabolic process;regulation of receptor-mediated endocytosis;regulation of transferrin receptor binding;positive regulation of ferrous iron binding;positive regulation of transferrin receptor binding;regulation of ferrous iron binding;ion homeostasis;regulation of adaptive immune response;production of molecular mediator of immune response;signaling;leukocyte mediated immunity;transition metal ion transport;biological adhesion;negative regulation of cell differentiation;regulation of cell differentiation;metal ion transport;cation homeostasis;tissue homeostasis;retina homeostasis;negative regulation of developmental process;positive regulation of binding;regulation of binding;macromolecule metabolic process;positive regulation of receptor binding;negative regulation of receptor binding;regulation of receptor binding;lymphocyte differentiation;hemopoiesis;defense response to Gram-negative bacterium;iron ion import into cell;hematopoietic or lymphoid organ development;neuron development;cellular protein metabolic process;immune effector process;lymphocyte mediated immunity;leukocyte cell-cell adhesion;cell adhesion;cell communication;generation of neurons;nervous system development;adaptive immune response;viral process;inorganic cation import into cell;import into cell; 4;6;5;5;4;4;7;5;7;3;4;5;4;6;6;5;6;3;3;3;4;5;3;5;2;6;6;3;3;6;3;4;4;6;6;4;7;7;5;6;3;6;6;5;6;4;5;4;4;5;4;7;4;4;4;6;4;5;4;9;6;10;4;3;7;4;3;3;5;4;5;3;4;4;3;3;4;5;3;6;3;5;5;5;6;7;3;4;4;2;3;5;5;4;3;4;2;5;4;3;4;3;4;10;3;3;3;3;6;6;2;7;4;5;4;4;4;2;6;3;3;5;6;4;8;5;4;5;4;4;8;6;5;6;5;5;4;8;3;6;6;7;3;9;6;3;4;4;6;4;5;3;3;3;2;4;4;5;2;2;6;5;3;2;4;4;4;4;4;5;3;6;6;5;4;5;6;5;4;4;3;3;4;4;4;3;5;9;2;2;2;4;3;4;4;4;4;4;4;6;5;6;5;4;5;6;3;7;5;3;5;5;7;4;5;2;3;4;5;10;9;9;4;4;3;4;6;6;4;5;5;5;3;4;2;3;7;5;4;1;2;6;7;6;8;5;6;5;3;2;4;8;2;4;4;7;7;5;6;3;5;4;4;7;7;6;5;5;6;8;4;5;5;3;5;5;3;4;7;5;4;4;7;5; GO:0005783;GO:0005788;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0030054;GO:0070161;GO:0030670;GO:0010008;GO:0005912;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0070013;GO:0005768;GO:0005769;GO:0016023;GO:0016020;GO:0098588;GO:0012507;GO:0043234;GO:0043235;GO:0042612;GO:0043230;GO:0043231;GO:0043233;GO:0005924;GO:0005925;GO:0044433;GO:0044432;GO:0044431;GO:0044437;GO:0030666;GO:0031090;GO:0030662;GO:0098552;GO:0042611;GO:0031974;GO:0030055;GO:0005773;GO:0005775;GO:0005774;GO:0031905;GO:0031904;GO:0031901;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0012506;GO:0044446;GO:0044444;GO:0044440;GO:0005737;GO:0009986;GO:0030658;GO:0030659;GO:0031982;GO:0031988;GO:0005794;GO:0097708;GO:0000139;GO:0031410;GO:0044459;GO:0005623;GO:0045335;GO:0030139;GO:1990712;GO:0030133;GO:0030135;GO:0030134;GO:0005575;GO:0098805;GO:0098802;GO:0005886;GO:1903561;GO:0032991;GO:0098797;GO:0098796;GO:0005576; endoplasmic reticulum;endoplasmic reticulum lumen;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;cell junction;anchoring junction;phagocytic vesicle membrane;endosome membrane;adherens junction;cell part;cell periphery;extracellular space;extracellular exosome;intracellular organelle lumen;endosome;early endosome;cytoplasmic, membrane-bounded vesicle;membrane;bounding membrane of organelle;ER to Golgi transport vesicle membrane;protein complex;receptor complex;MHC class I protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cell-substrate adherens junction;focal adhesion;cytoplasmic vesicle part;endoplasmic reticulum part;Golgi apparatus part;vacuolar part;endocytic vesicle membrane;organelle membrane;coated vesicle membrane;side of membrane;MHC protein complex;membrane-enclosed lumen;cell-substrate junction;vacuole;vacuolar lumen;vacuolar membrane;early endosome lumen;endosome lumen;early endosome membrane;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;vesicle membrane;intracellular organelle part;cytoplasmic part;endosomal part;cytoplasm;cell surface;transport vesicle membrane;cytoplasmic vesicle membrane;vesicle;membrane-bounded vesicle;Golgi apparatus;intracellular vesicle;Golgi membrane;cytoplasmic vesicle;plasma membrane part;cell;phagocytic vesicle;endocytic vesicle;HFE-transferrin receptor complex;transport vesicle;coated vesicle;ER to Golgi transport vesicle;cellular_component;whole membrane;plasma membrane receptor complex;plasma membrane;extracellular vesicle;macromolecular complex;plasma membrane protein complex;membrane protein complex;extracellular region; 4;5;3;2;2;2;4;2;3;5;5;4;2;3;3;4;4;4;5;5;2;4;5;3;4;6;3;4;3;4;5;4;4;4;4;4;3;4;3;5;2;3;5;5;4;6;6;6;3;3;3;2;3;4;3;4;5;4;3;4;5;4;5;4;4;5;5;3;2;7;6;4;4;6;5;1;3;4;3;3;2;4;3;2; GO:0005488;GO:0001948;GO:0005515;GO:0003674;GO:0042802;GO:0097367; binding;glycoprotein binding;protein binding;molecular_function;identical protein binding;carbohydrate derivative binding; 2;4;3;1;4;3; K08055 map04612; Antigen processing and presentation; IPR015707;IPR007110;IPR013783;IPR003597;IPR003006; Beta-2-Microglobulin;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular O15357 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2 - [SHIP2_HUMAN] 1.129 0.989 0.917 1.146 1.007 1.139 1.141557128 nan 1.138033764 nan 0.927199191 nan 1.131082423 nan GO:0019222;GO:0001501;GO:0001503;GO:0044281;GO:0043434;GO:0071840;GO:0044710;GO:0044711;GO:0010605;GO:0048513;GO:0048519;GO:0042127;GO:0060255;GO:0046488;GO:0046486;GO:0010033;GO:0016192;GO:0036075;GO:0010243;GO:0043647;GO:0002376;GO:0031529;GO:0005996;GO:0019637;GO:0044707;GO:0009892;GO:1901576;GO:0016043;GO:0065007;GO:0046856;GO:0048705;GO:0009887;GO:0006629;GO:0006810;GO:0019318;GO:0050794;GO:0008150;GO:0008152;GO:0048731;GO:0044723;GO:0051234;GO:0090407;GO:0006897;GO:0008654;GO:1901698;GO:1901615;GO:0016311;GO:0009791;GO:0044249;GO:0022607;GO:0009653;GO:0044699;GO:0009719;GO:0030030;GO:0022610;GO:0046839;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0009987;GO:0019751;GO:0060349;GO:0006661;GO:0005975;GO:0044255;GO:0030258;GO:0001958;GO:0009725;GO:0010629;GO:0043170;GO:0006066;GO:0046474;GO:0006006;GO:0050896;GO:0060350;GO:0006650;GO:0043933;GO:0030031;GO:0006644;GO:0030036;GO:0060348;GO:0032868;GO:0007275;GO:0045017;GO:0071822;GO:1902589;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0030029;GO:0044767;GO:0009058;GO:0044763;GO:0007155;GO:0042221;GO:0051179;GO:0008610;GO:1901700;GO:0044238;GO:0007015;GO:0007010;GO:0006996;GO:0048856;GO:0044237;GO:0006796;GO:0044085;GO:1901652;GO:0006793;GO:0097178;GO:0048523; regulation of metabolic process;skeletal system development;ossification;small molecule metabolic process;response to peptide hormone;cellular component organization or biogenesis;single-organism metabolic process;single-organism biosynthetic process;negative regulation of macromolecule metabolic process;animal organ development;negative regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;phosphatidylinositol metabolic process;glycerolipid metabolic process;response to organic substance;vesicle-mediated transport;replacement ossification;response to organonitrogen compound;inositol phosphate metabolic process;immune system process;ruffle organization;monosaccharide metabolic process;organophosphate metabolic process;single-multicellular organism process;negative regulation of metabolic process;organic substance biosynthetic process;cellular component organization;biological regulation;phosphatidylinositol dephosphorylation;skeletal system morphogenesis;organ morphogenesis;lipid metabolic process;transport;hexose metabolic process;regulation of cellular process;biological_process;metabolic process;system development;single-organism carbohydrate metabolic process;establishment of localization;organophosphate biosynthetic process;endocytosis;phospholipid biosynthetic process;response to nitrogen compound;organic hydroxy compound metabolic process;dephosphorylation;post-embryonic development;cellular biosynthetic process;cellular component assembly;anatomical structure morphogenesis;single-organism process;response to endogenous stimulus;cell projection organization;biological adhesion;phospholipid dephosphorylation;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;polyol metabolic process;bone morphogenesis;phosphatidylinositol biosynthetic process;carbohydrate metabolic process;cellular lipid metabolic process;lipid modification;endochondral ossification;response to hormone;negative regulation of gene expression;macromolecule metabolic process;alcohol metabolic process;glycerophospholipid biosynthetic process;glucose metabolic process;response to stimulus;endochondral bone morphogenesis;glycerophospholipid metabolic process;macromolecular complex subunit organization;cell projection assembly;phospholipid metabolic process;actin cytoskeleton organization;bone development;response to insulin;multicellular organism development;glycerolipid biosynthetic process;protein complex subunit organization;single-organism organelle organization;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;actin filament-based process;single-organism developmental process;biosynthetic process;single-organism cellular process;cell adhesion;response to chemical;localization;lipid biosynthetic process;response to oxygen-containing compound;primary metabolic process;actin filament organization;cytoskeleton organization;organelle organization;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;response to peptide;phosphorus metabolic process;ruffle assembly;negative regulation of cellular process; 3;5;4;4;5;2;3;4;4;4;2;4;4;7;5;4;5;5;4;4;2;5;5;4;3;3;4;3;2;7;5;4;4;4;6;3;1;2;4;4;3;5;6;5;4;4;6;4;4;4;3;2;3;4;2;6;2;4;2;3;2;6;5;7;4;4;5;6;4;5;4;5;6;7;2;6;6;4;5;5;5;4;6;4;5;5;4;2;3;5;5;4;3;3;3;3;3;2;5;4;3;6;5;4;3;3;5;3;5;4;6;3; GO:0016020;GO:0005794;GO:0042995;GO:0043231;GO:0043232;GO:0098858;GO:0005829;GO:0030175;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0005856;GO:0005737;GO:0031252;GO:0044424;GO:0012505;GO:0044444;GO:0044464;GO:0005623;GO:0071944;GO:0030027;GO:0005886;GO:0005575; membrane;Golgi apparatus;cell projection;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;actin-based cell projection;cytosol;filopodium;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;cytoskeleton;cytoplasm;cell leading edge;intracellular part;endomembrane system;cytoplasmic part;cell part;cell;cell periphery;lamellipodium;plasma membrane;cellular_component; 2;4;3;4;4;4;5;5;3;3;3;3;2;5;4;3;3;3;4;2;2;3;4;3;1; GO:0019904;GO:0016787;GO:0003674;GO:0005488;GO:0042169;GO:0005515;GO:0003824; protein domain specific binding;hydrolase activity;molecular_function;binding;SH2 domain binding;protein binding;catalytic activity; 4;3;1;2;5;3;2; K15909 map00562;map04070;map04662;map04666;map04910; Inositol phosphate metabolism;Phosphatidylinositol signaling system;B cell receptor signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway; IPR005135;IPR000300;IPR013761;IPR000980;IPR001660; Endonuclease/exonuclease/phosphatase;Inositol polyphosphate-related phosphatase;Sterile alpha motif/pointed domain;SH2 domain;Sterile alpha motif domain; nucleus Hs4755142_1 2329.0 U [U] Intracellular trafficking, secretion, and vesicular transport; P01008 Antithrombin-III OS=Homo sapiens OX=9606 GN=SERPINC1 PE=1 SV=1 - [ANT3_HUMAN] 1.046 1.016 0.998 1.041 1.023 0.973 1.029527559 0.002553121 1.017595308 0.00862046 0.982283465 0.00107509 0.951124145 0.000414565 GO:0007599;GO:0080090;GO:0019222;GO:0048585;GO:0007596;GO:0048583;GO:0031348;GO:0031347;GO:0050728;GO:0010605;GO:0050727;GO:0044092;GO:0048519;GO:0007597;GO:0060255;GO:2000257;GO:0030162;GO:0009605;GO:0044707;GO:0019538;GO:0031667;GO:0030193;GO:0009892;GO:2000266;GO:0050789;GO:0044267;GO:0051346;GO:0044260;GO:1900046;GO:0065007;GO:0065009;GO:0065008;GO:0007584;GO:0050790;GO:0044710;GO:0042060;GO:0050794;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0050818;GO:0051336;GO:0050896;GO:0032102;GO:0006954;GO:0032101;GO:0009611;GO:0043086;GO:0044699;GO:0051248;GO:0051246;GO:0006508;GO:1903034;GO:1903035;GO:0032501;GO:0050878;GO:0009987;GO:0032269;GO:0032268;GO:0043170;GO:0051239;GO:0045861;GO:0080134;GO:0009991;GO:0031324;GO:0031323;GO:0061041;GO:0072376;GO:0072378;GO:0071704;GO:0010466;GO:0052547;GO:0052548;GO:0010951;GO:0042221;GO:0044238;GO:0044237;GO:0048523; hemostasis;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;negative regulation of defense response;regulation of defense response;negative regulation of inflammatory response;negative regulation of macromolecule metabolic process;regulation of inflammatory response;negative regulation of molecular function;negative regulation of biological process;blood coagulation, intrinsic pathway;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;response to external stimulus;single-multicellular organism process;protein metabolic process;response to nutrient levels;regulation of blood coagulation;negative regulation of metabolic process;regulation of blood coagulation, intrinsic pathway;regulation of biological process;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of hemostasis;biological regulation;regulation of molecular function;regulation of biological quality;response to nutrient;regulation of catalytic activity;single-organism metabolic process;wound healing;regulation of cellular process;defense response;response to stress;coagulation;biological_process;metabolic process;regulation of coagulation;regulation of hydrolase activity;response to stimulus;negative regulation of response to external stimulus;inflammatory response;regulation of response to external stimulus;response to wounding;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;proteolysis;regulation of response to wounding;negative regulation of response to wounding;multicellular organismal process;regulation of body fluid levels;cellular process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;macromolecule metabolic process;regulation of multicellular organismal process;negative regulation of proteolysis;regulation of response to stress;response to extracellular stimulus;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of wound healing;protein activation cascade;blood coagulation, fibrin clot formation;organic substance metabolic process;negative regulation of peptidase activity;regulation of peptidase activity;regulation of endopeptidase activity;negative regulation of endopeptidase activity;response to chemical;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 5;4;3;3;5;3;4;5;5;4;5;4;2;4;4;4;6;3;3;4;5;5;3;5;2;5;6;4;4;2;3;3;4;4;3;5;3;4;3;4;1;2;4;5;2;4;5;4;4;5;2;5;5;5;5;4;2;4;2;5;5;4;3;6;4;4;4;4;6;3;4;3;7;6;7;8;3;3;3;3; GO:0031982;GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0072562;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;blood microparticle;cell part;cell;cell periphery;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;2;3;2;3;3;2;2;3;4;2;3;3;3;1;2; GO:0098772;GO:0004866;GO:0097367;GO:0061135;GO:0003674;GO:0005488;GO:1901681;GO:0005539;GO:0019899;GO:0004857;GO:0043168;GO:0043167;GO:0002020;GO:0030414;GO:0004867;GO:0008201;GO:0005515;GO:0030234;GO:0061134; molecular function regulator;endopeptidase inhibitor activity;carbohydrate derivative binding;endopeptidase regulator activity;molecular_function;binding;sulfur compound binding;glycosaminoglycan binding;enzyme binding;enzyme inhibitor activity;anion binding;ion binding;protease binding;peptidase inhibitor activity;serine-type endopeptidase inhibitor activity;heparin binding;protein binding;enzyme regulator activity;peptidase regulator activity; 2;6;3;5;1;2;3;4;4;4;4;3;5;5;7;4;3;3;4; K03911 map04610; Complement and coagulation cascades; IPR023795;IPR000215;IPR023796;IPR033829;IPR015555; Serpin, conserved site;Serpin family;Serpin domain;Antithrombin serpin domain;Antithrombin-III; extracellular Hs4502261 963.0 V [V] Defense mechanisms; Q9BY66 Lysine-specific demethylase 5D OS=Homo sapiens OX=9606 GN=KDM5D PE=1 SV=2 - [KDM5D_HUMAN] 1.074 1.357 0.812 1.032 1.02 0.825 0.791451732 nan 1.011764706 nan 0.598378777 nan 0.808823529 nan GO:0002449;GO:0034720;GO:0002376;GO:0019882;GO:0043933;GO:0008214;GO:0002457;GO:0002456;GO:0044699;GO:0044267;GO:0006482;GO:0044260;GO:0071840;GO:0016043;GO:0071704;GO:0016577;GO:0016570;GO:0002250;GO:0070988;GO:0009987;GO:0044710;GO:0006464;GO:0043412;GO:0036211;GO:0044763;GO:0002460;GO:0008152;GO:0006955;GO:0002443;GO:0006996;GO:0044238;GO:0051276;GO:0019538;GO:0050896;GO:0044237;GO:0043170;GO:0006325;GO:1902589;GO:0070076;GO:0002252;GO:0008150;GO:0016568;GO:0016569; lymphocyte mediated immunity;histone H3-K4 demethylation;immune system process;antigen processing and presentation;macromolecular complex subunit organization;protein dealkylation;T cell antigen processing and presentation;T cell mediated immunity;single-organism process;cellular protein metabolic process;protein demethylation;cellular macromolecule metabolic process;cellular component organization or biogenesis;cellular component organization;organic substance metabolic process;histone demethylation;histone modification;adaptive immune response;demethylation;cellular process;single-organism metabolic process;cellular protein modification process;macromolecule modification;protein modification process;single-organism cellular process;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;metabolic process;immune response;leukocyte mediated immunity;organelle organization;primary metabolic process;chromosome organization;protein metabolic process;response to stimulus;cellular metabolic process;macromolecule metabolic process;chromatin organization;single-organism organelle organization;histone lysine demethylation;immune effector process;biological_process;chromatin modification;covalent chromatin modification; 5;7;2;3;4;7;4;6;2;5;4;4;2;3;3;5;4;4;4;2;3;6;5;5;3;5;2;3;4;4;3;5;4;2;3;4;5;4;6;3;1;6;7; GO:0031974;GO:0005623;GO:0005622;GO:0043227;GO:0043226;GO:0070013;GO:0005654;GO:0005575;GO:0044422;GO:0043231;GO:0043233;GO:0031981;GO:0044464;GO:0043229;GO:0044446;GO:0044428;GO:0044424;GO:0005634; membrane-enclosed lumen;cell;intracellular;membrane-bounded organelle;organelle;intracellular organelle lumen;nucleoplasm;cellular_component;organelle part;intracellular membrane-bounded organelle;organelle lumen;nuclear lumen;cell part;intracellular organelle;intracellular organelle part;nuclear part;intracellular part;nucleus; 2;2;3;3;2;4;5;1;2;4;3;5;2;3;3;4;3;5; GO:0005488;GO:0032451;GO:0003677;GO:1901363;GO:0003674;GO:0003676;GO:0016491;GO:0016706;GO:0016705;GO:0008270;GO:0032452;GO:0043167;GO:0046872;GO:0043169;GO:0046914;GO:0003824;GO:0051213;GO:0097159;GO:0032453; binding;demethylase activity;DNA binding;heterocyclic compound binding;molecular_function;nucleic acid binding;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;zinc ion binding;histone demethylase activity;ion binding;metal ion binding;cation binding;transition metal ion binding;catalytic activity;dioxygenase activity;organic cyclic compound binding;histone demethylase activity (H3-K4 specific); 2;3;5;3;1;4;3;5;4;7;4;3;5;4;6;2;4;3;5; K11446 IPR003349;IPR019787;IPR019786;IPR004198;IPR011011;IPR013083;IPR003347;IPR001606;IPR001965;IPR013637; JmjN domain;Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;Zinc finger, C5HC2-type;Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;JmjC domain;ARID DNA-binding domain;Zinc finger, PHD-type;Lysine-specific demethylase-like domain; nucleus Hs4759150 3170.0 R [R] General function prediction only; A0A0C4DH43 Immunoglobulin heavy variable 2-70D OS=Homo sapiens OX=9606 GN=IGHV2-70D PE=3 SV=1 - [HV70D_HUMAN] 0.485 1.831 0.662 0.641 1.827 0.75 0.264882578 3.55E-09 0.350848385 5.84E-09 0.361551065 3.58E-09 0.410509031 1.91E-07 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular A0A0C4DH42 Immunoglobulin heavy variable 3-66 OS=Homo sapiens OX=9606 GN=IGHV3-66 PE=3 SV=1 - [HV366_HUMAN] 1.052 1.081 0.645 1.182 1.229 1.363 0.973172988 0.717746817 0.961757526 0.713403978 0.59666975 0.018071038 1.109031733 0.396810409 IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q8WXH2 Junctophilin-3 OS=Homo sapiens OX=9606 GN=JPH3 PE=2 SV=2 - [JPH3_HUMAN] 1.045 0.911 1.47 0.98 0.793 0.594 1.147091109 nan 1.235813367 nan 1.613611416 nan 0.749054224 nan GO:0051049;GO:0032386;GO:0048583;GO:0051283;GO:0032845;GO:0050848;GO:0007165;GO:0098771;GO:0034765;GO:0034762;GO:0051716;GO:0009966;GO:0051208;GO:0051209;GO:0048519;GO:0010522;GO:0019725;GO:0019722;GO:0051282;GO:0007613;GO:0060314;GO:1902656;GO:0070838;GO:0032844;GO:0090279;GO:0003008;GO:0044700;GO:0044707;GO:0044708;GO:0070588;GO:0007204;GO:0048878;GO:0098916;GO:0070509;GO:0055074;GO:0032412;GO:0019932;GO:0035556;GO:0050789;GO:0035640;GO:0065007;GO:0098662;GO:0098660;GO:0065009;GO:0065008;GO:0097553;GO:1903649;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:0050794;GO:0008150;GO:0051238;GO:0051235;GO:0051234;GO:0050877;GO:0046907;GO:0022898;GO:0050896;GO:0050890;GO:2001257;GO:0099536;GO:0099537;GO:0050803;GO:0050801;GO:0055065;GO:0050804;GO:0023052;GO:0023051;GO:0010646;GO:0044699;GO:0072507;GO:1902531;GO:0072503;GO:0050885;GO:0032409;GO:0007612;GO:0032501;GO:0006875;GO:0006874;GO:0009987;GO:0006873;GO:0048168;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0032879;GO:0055085;GO:0016482;GO:0072511;GO:1904062;GO:0048167;GO:0007610;GO:0060341;GO:1903169;GO:0042592;GO:0050905;GO:0007611;GO:0043269;GO:0010469;GO:0060401;GO:0060402;GO:0010959;GO:0034220;GO:0044765;GO:0044763;GO:0007268;GO:0051649;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:1901019;GO:0051480;GO:0051279;GO:0051924;GO:2000021;GO:1902582;GO:0098655;GO:0048523; regulation of transport;regulation of intracellular transport;regulation of response to stimulus;negative regulation of sequestering of calcium ion;negative regulation of homeostatic process;regulation of calcium-mediated signaling;signal transduction;inorganic ion homeostasis;regulation of ion transmembrane transport;regulation of transmembrane transport;cellular response to stimulus;regulation of signal transduction;sequestering of calcium ion;release of sequestered calcium ion into cytosol;negative regulation of biological process;regulation of calcium ion transport into cytosol;cellular homeostasis;calcium-mediated signaling;regulation of sequestering of calcium ion;memory;regulation of ryanodine-sensitive calcium-release channel activity;calcium ion import into cytosol;divalent metal ion transport;regulation of homeostatic process;regulation of calcium ion import;system process;single organism signaling;single-multicellular organism process;single-organism behavior;calcium ion transmembrane transport;positive regulation of cytosolic calcium ion concentration;chemical homeostasis;anterograde trans-synaptic signaling;calcium ion import;calcium ion homeostasis;regulation of ion transmembrane transporter activity;second-messenger-mediated signaling;intracellular signal transduction;regulation of biological process;exploration behavior;biological regulation;inorganic cation transmembrane transport;inorganic ion transmembrane transport;regulation of molecular function;regulation of biological quality;calcium ion transmembrane import into cytosol;regulation of cytoplasmic transport;cation transport;ion transport;transport;calcium ion transport;regulation of cellular process;biological_process;sequestering of metal ion;maintenance of location;establishment of localization;neurological system process;intracellular transport;regulation of transmembrane transporter activity;response to stimulus;cognition;regulation of cation channel activity;synaptic signaling;trans-synaptic signaling;regulation of synapse structure or activity;ion homeostasis;metal ion homeostasis;modulation of synaptic transmission;signaling;regulation of signaling;regulation of cell communication;single-organism process;divalent inorganic cation homeostasis;regulation of intracellular signal transduction;cellular divalent inorganic cation homeostasis;neuromuscular process controlling balance;regulation of transporter activity;learning;multicellular organismal process;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular process;cellular ion homeostasis;regulation of neuronal synaptic plasticity;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of localization;transmembrane transport;cytosolic transport;divalent inorganic cation transport;regulation of cation transmembrane transport;regulation of synaptic plasticity;behavior;regulation of cellular localization;regulation of calcium ion transmembrane transport;homeostatic process;neuromuscular process;learning or memory;regulation of ion transport;regulation of receptor activity;cytosolic calcium ion transport;calcium ion transport into cytosol;regulation of metal ion transport;ion transmembrane transport;single-organism transport;single-organism cellular process;synaptic transmission;establishment of localization in cell;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;locomotion;regulation of calcium ion transmembrane transporter activity;regulation of cytosolic calcium ion concentration;regulation of release of sequestered calcium ion into cytosol;regulation of calcium ion transport;regulation of ion homeostasis;single-organism intracellular transport;cation transmembrane transport;negative regulation of cellular process; 4;5;3;4;3;6;4;7;5;4;3;4;5;5;2;5;4;7;4;5;5;7;8;3;6;3;3;3;3;8;11;5;7;10;9;6;6;5;2;4;2;7;6;3;3;8;6;6;5;4;9;3;1;4;3;3;4;5;5;2;5;7;5;6;4;6;8;4;2;3;4;2;8;5;8;6;4;5;2;8;9;2;6;6;7;7;7;5;3;4;6;7;6;5;2;4;7;4;5;4;5;4;10;6;6;5;4;3;8;4;4;4;2;3;3;2;7;10;5;7;4;5;6;3; GO:0005783;GO:0031224;GO:0016021;GO:0016020;GO:0033017;GO:0098588;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0044464;GO:0043229;GO:0043227;GO:0044432;GO:0005886;GO:0012505;GO:0031090;GO:0044444;GO:0044422;GO:0042175;GO:0005737;GO:0005789;GO:0030314;GO:0005623;GO:0005622;GO:0016528;GO:0016529;GO:0014701;GO:0071944;GO:0044446;GO:0043226;GO:0032991;GO:0005575; endoplasmic reticulum;intrinsic component of membrane;integral component of membrane;membrane;sarcoplasmic reticulum membrane;bounding membrane of organelle;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;cell part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;plasma membrane;endomembrane system;organelle membrane;cytoplasmic part;organelle part;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasm;endoplasmic reticulum membrane;junctional membrane complex;cell;intracellular;sarcoplasm;sarcoplasmic reticulum;junctional sarcoplasmic reticulum membrane;cell periphery;intracellular organelle part;organelle;macromolecular complex;cellular_component; 4;3;4;2;4;4;3;4;3;2;2;3;3;4;3;3;3;4;2;3;4;3;4;2;3;5;5;5;3;3;2;2;1; GO:0005261;GO:0005262;GO:0060089;GO:0015085;GO:0046873;GO:0099604;GO:0099600;GO:0003674;GO:0022803;GO:0015278;GO:0022891;GO:0022890;GO:0022892;GO:0015075;GO:0015267;GO:0015276;GO:0072509;GO:0005216;GO:0022836;GO:0022834;GO:0022838;GO:0038023;GO:0004872;GO:0004871;GO:0005057;GO:0004888;GO:0005215;GO:0008324;GO:0005217;GO:0022857; cation channel activity;calcium channel activity;molecular transducer activity;calcium ion transmembrane transporter activity;metal ion transmembrane transporter activity;ligand-gated calcium channel activity;transmembrane receptor activity;molecular_function;passive transmembrane transporter activity;calcium-release channel activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;channel activity;ligand-gated ion channel activity;divalent inorganic cation transmembrane transporter activity;ion channel activity;gated channel activity;ligand-gated channel activity;substrate-specific channel activity;signaling receptor activity;receptor activity;signal transducer activity;receptor signaling protein activity;transmembrane signaling receptor activity;transporter activity;cation transmembrane transporter activity;intracellular ligand-gated ion channel activity;transmembrane transporter activity; 7;8;2;9;8;5;4;1;4;4;4;7;3;5;5;6;8;6;6;5;5;3;3;2;3;4;2;6;7;3; K19530 IPR003409;IPR017191; MORN motif;Junctophilin; nucleus Hs21704283 1533.0 R [R] General function prediction only; Q9P2S6 Ankyrin repeat and MYND domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKMY1 PE=2 SV=2 - [ANKY1_HUMAN] 0.862 1.137 0.837 1.044 0.987 2.015 0.758135444 0.180752777 1.05775076 0.806958762 0.736147757 0.112666219 2.04154002 0.14960973 GO:0043169;GO:0046872;GO:0003674;GO:0005488;GO:0043167; cation binding;metal ion binding;molecular_function;binding;ion binding; 4;5;1;2;3; IPR003409;IPR002110;IPR002893;IPR020683; MORN motif;Ankyrin repeat;Zinc finger, MYND-type;Ankyrin repeat-containing domain; nucleus 332294894 75.9 S [S] Function unknown; COG4642 Uncharacterized conserved protein P43652 Afamin OS=Homo sapiens OX=9606 GN=AFM PE=1 SV=1 - [AFAM_HUMAN] 0.936 1.111 0.983 0.966 1.095 0.916 0.842484248 3.10E-36 0.882191781 5.71E-13 0.884788479 0.182227741 0.83652968 0.18300375 GO:0044699;GO:0051180;GO:0006810;GO:0044765;GO:0008150;GO:0051234;GO:0051179;GO:1902578; single-organism process;vitamin transport;transport;single-organism transport;biological_process;establishment of localization;localization;single-organism localization; 2;5;4;4;1;3;2;3; GO:0043227;GO:1903561;GO:0005615;GO:0072562;GO:0043226;GO:0031982;GO:0070062;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;extracellular vesicle;extracellular space;blood microparticle;organelle;vesicle;extracellular exosome;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;3;3;3;2;4;4;3;1;2;2; GO:0003674;GO:0005488;GO:1901363;GO:0036094;GO:0008431;GO:0097159;GO:0019842; molecular_function;binding;heterocyclic compound binding;small molecule binding;vitamin E binding;organic cyclic compound binding;vitamin binding; 1;2;3;3;4;3;4; IPR021177;IPR000264;IPR020858;IPR020857;IPR014760; Serum albumin/Alpha-fetoprotein/Afamin;ALB/AFP/VDB;Serum albumin-like;Serum albumin, conserved site;Serum albumin, N-terminal; extracellular P37173 TGF-beta receptor type-2 OS=Homo sapiens OX=9606 GN=TGFBR2 PE=1 SV=2 - [TGFR2_HUMAN] 1.24 1.124 0.698 1.048 1.264 0.57 1.103202847 nan 0.829113924 nan 0.620996441 nan 0.450949367 nan GO:0001501;GO:2000736;GO:0051716;GO:0014031;GO:0048589;GO:0018210;GO:2000738;GO:0060541;GO:0031100;GO:0048583;GO:0045859;GO:0042325;GO:0042327;GO:0010631;GO:0009605;GO:0034284;GO:0019538;GO:0060322;GO:0048562;GO:0048565;GO:0009893;GO:0048568;GO:1901342;GO:0050789;GO:0000904;GO:0051347;GO:0000902;GO:0002684;GO:0002682;GO:0060462;GO:0060463;GO:0048705;GO:0048704;GO:0048706;GO:0048701;GO:0098609;GO:2000377;GO:0043412;GO:0048863;GO:0043415;GO:0043416;GO:0002521;GO:0002520;GO:0002053;GO:0097305;GO:0048639;GO:0048638;GO:0048635;GO:0048634;GO:0051128;GO:0001837;GO:0014070;GO:1904019;GO:1904018;GO:0060284;GO:0045621;GO:0003418;GO:0072091;GO:0008284;GO:0008285;GO:0035239;GO:0008283;GO:0050870;GO:0001654;GO:0042110;GO:0003415;GO:0060021;GO:0010718;GO:0018107;GO:0060433;GO:0018105;GO:0045926;GO:0060434;GO:0060439;GO:0060438;GO:0060349;GO:0060348;GO:0022407;GO:0061041;GO:0002088;GO:0008219;GO:0007275;GO:0002643;GO:0002645;GO:0033993;GO:0002649;GO:0022409;GO:0048598;GO:0006468;GO:1990086;GO:0006464;GO:0044767;GO:0044763;GO:0060485;GO:1901700;GO:0051272;GO:0040012;GO:0040017;GO:0048856;GO:1902107;GO:0006796;GO:2000026;GO:0006793;GO:0023057;GO:0014855;GO:0048523;GO:0048522;GO:0034112;GO:0034110;GO:0032147;GO:0007165;GO:0007166;GO:0007167;GO:0032989;GO:0002517;GO:0002514;GO:0002513;GO:0045785;GO:0031099;GO:0070848;GO:0098868;GO:0044093;GO:0002062;GO:0002063;GO:0016202;GO:0030217;GO:0044703;GO:1903708;GO:1903706;GO:0010033;GO:0051704;GO:0018209;GO:0010632;GO:0009790;GO:0031667;GO:0045843;GO:0090092;GO:0035162;GO:0045321;GO:0001763;GO:0044267;GO:0010646;GO:0044260;GO:0001568;GO:0001569;GO:0007182;GO:0009887;GO:0050793;GO:0050790;GO:0017015;GO:0009888;GO:0050794;GO:0051239;GO:0051234;GO:0006897;GO:0007224;GO:0010717;GO:0050896;GO:0006898;GO:0051338;GO:0002694;GO:0002696;GO:2000145;GO:2000147;GO:0043010;GO:0043011;GO:0051241;GO:0032101;GO:0001944;GO:0090288;GO:0055123;GO:0043403;GO:0070887;GO:0000003;GO:0044699;GO:0090287;GO:0051249;GO:0051240;GO:0022603;GO:0051246;GO:0051247;GO:1903039;GO:0010769;GO:0001865;GO:0031399;GO:1903034;GO:1903036;GO:1903037;GO:0040011;GO:0072593;GO:0051270;GO:0090132;GO:0090130;GO:0042493;GO:0048738;GO:0051674;GO:0045619;GO:0048731;GO:0048732;GO:0055017;GO:0030323;GO:0030324;GO:0050865;GO:0050867;GO:0050863;GO:0014706;GO:0001525;GO:1903845;GO:1903844;GO:0060425;GO:1902105;GO:0060038;GO:0045937;GO:0061138;GO:0046620;GO:0046621;GO:0022414;GO:0070489;GO:0043627;GO:0042221;GO:0035295;GO:0070486;GO:0002651;GO:0009628;GO:0009743;GO:0045595;GO:0044237;GO:0009749;GO:0060537;GO:0019220;GO:0019222;GO:0048588;GO:0048585;GO:0048584;GO:0048468;GO:0072359;GO:0072358;GO:0071840;GO:0007219;GO:0048864;GO:0009968;GO:0009966;GO:0048869;GO:0048513;GO:0048514;GO:0010720;GO:0048518;GO:0048519;GO:0003416;GO:0003417;GO:0003413;GO:0042127;GO:0048762;GO:0007179;GO:0007178;GO:0044700;GO:0002507;GO:0044702;GO:0016192;GO:0044707;GO:0044706;GO:0002274;GO:0048645;GO:0002376;GO:0033002;GO:0048646;GO:0009725;GO:0022604;GO:0033674;GO:0006928;GO:1901862;GO:0090101;GO:0043549;GO:0048640;GO:0016477;GO:0030879;GO:0006810;GO:0055026;GO:0055022;GO:0055024;GO:1904888;GO:0002666;GO:0055021;GO:0001775;GO:0001773;GO:0072089;GO:0002661;GO:0001570;GO:0007420;GO:0007423;GO:0012501;GO:0080134;GO:0031401;GO:0006950;GO:0007369;GO:0030155;GO:0030154;GO:0060044;GO:0045582;GO:0009612;GO:0060043;GO:0061061;GO:0016337;GO:0001701;GO:0060440;GO:0060443;GO:0032270;GO:0060562;GO:0043009;GO:0060560;GO:0097028;GO:0032502;GO:0032501;GO:0009987;GO:0032879;GO:0071363;GO:0009746;GO:0051251;GO:0071560;GO:0010770;GO:0048545;GO:0048754;GO:0010634;GO:0007389;GO:0045765;GO:0045766;GO:0002573;GO:0071704;GO:0071310;GO:0048729;GO:0030335;GO:0030334;GO:0007584;GO:0006915;GO:0061448;GO:0051174;GO:0036314;GO:0051179;GO:0044238;GO:0080090;GO:0046638;GO:0046637;GO:0046635;GO:0046634;GO:0046632;GO:0046631;GO:0035265;GO:0002664;GO:0007517;GO:0070723;GO:0010604;GO:0002663;GO:0009611;GO:0018193;GO:0030512;GO:0060255;GO:1901861;GO:0046649;GO:0048534;GO:0045580;GO:0051216;GO:0048870;GO:0042246;GO:0071559;GO:0060419;GO:0016049;GO:2000379;GO:0060389;GO:0016043;GO:0065007;GO:2000648;GO:0065009;GO:0071593;GO:0051130;GO:0009719;GO:0051136;GO:0051138;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0048659;GO:0016310;GO:0009792;GO:0023052;GO:0010648;GO:0023051;GO:0001667;GO:0009653;GO:0043085;GO:0007417;GO:0022612;GO:0022610;GO:0060350;GO:0060351;GO:0060420;GO:0007507;GO:0060429;GO:0045597;GO:0061117;GO:0051093;GO:0032268;GO:0007568;GO:0007399;GO:0051094;GO:0007565;GO:0007566;GO:0043170;GO:0030098;GO:0030099;GO:0030097;GO:0045860;GO:0071495;GO:0009991;GO:0031325;GO:0031323;GO:0090303;GO:0002009;GO:0040007;GO:0040008;GO:0010464;GO:0010467;GO:0010463;GO:0003433;GO:0003430;GO:0003431;GO:0010468;GO:0048660;GO:0048661;GO:0034109;GO:0010562;GO:0007159;GO:0007155;GO:0007154;GO:0001932;GO:0098602;GO:0045927;GO:0001934; skeletal system development;regulation of stem cell differentiation;cellular response to stimulus;mesenchymal cell development;developmental growth;peptidyl-threonine modification;positive regulation of stem cell differentiation;respiratory system development;organ regeneration;regulation of response to stimulus;regulation of protein kinase activity;regulation of phosphorylation;positive regulation of phosphorylation;epithelial cell migration;response to external stimulus;response to monosaccharide;protein metabolic process;head development;embryonic organ morphogenesis;digestive tract development;positive regulation of metabolic process;embryonic organ development;regulation of vasculature development;regulation of biological process;cell morphogenesis involved in differentiation;positive regulation of transferase activity;cell morphogenesis;positive regulation of immune system process;regulation of immune system process;lung lobe development;lung lobe morphogenesis;skeletal system morphogenesis;embryonic skeletal system morphogenesis;embryonic skeletal system development;embryonic cranial skeleton morphogenesis;cell-cell adhesion;regulation of reactive oxygen species metabolic process;macromolecule modification;stem cell differentiation;positive regulation of skeletal muscle tissue regeneration;regulation of skeletal muscle tissue regeneration;leukocyte differentiation;immune system development;positive regulation of mesenchymal cell proliferation;response to alcohol;positive regulation of developmental growth;regulation of developmental growth;negative regulation of muscle organ development;regulation of muscle organ development;regulation of cellular component organization;epithelial to mesenchymal transition;response to organic cyclic compound;epithelial cell apoptotic process;positive regulation of vasculature development;regulation of cell development;positive regulation of lymphocyte differentiation;growth plate cartilage chondrocyte differentiation;regulation of stem cell proliferation;positive regulation of cell proliferation;negative regulation of cell proliferation;tube morphogenesis;cell proliferation;positive regulation of T cell activation;eye development;T cell activation;chondrocyte hypertrophy;palate development;positive regulation of epithelial to mesenchymal transition;peptidyl-threonine phosphorylation;bronchus development;peptidyl-serine phosphorylation;negative regulation of growth;bronchus morphogenesis;trachea morphogenesis;trachea development;bone morphogenesis;bone development;regulation of cell-cell adhesion;regulation of wound healing;lens development in camera-type eye;cell death;multicellular organism development;regulation of tolerance induction;positive regulation of tolerance induction;response to lipid;regulation of tolerance induction to self antigen;positive regulation of cell-cell adhesion;embryonic morphogenesis;protein phosphorylation;lens fiber cell apoptotic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;mesenchyme development;response to oxygen-containing compound;positive regulation of cellular component movement;regulation of locomotion;positive regulation of locomotion;anatomical structure development;positive regulation of leukocyte differentiation;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of signaling;striated muscle cell proliferation;negative regulation of cellular process;positive regulation of cellular process;positive regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;activation of protein kinase activity;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;cellular component morphogenesis;T cell tolerance induction;B cell tolerance induction;tolerance induction to self antigen;positive regulation of cell adhesion;regeneration;response to growth factor;bone growth;positive regulation of molecular function;chondrocyte differentiation;chondrocyte development;regulation of striated muscle tissue development;T cell differentiation;multi-organism reproductive process;positive regulation of hemopoiesis;regulation of hemopoiesis;response to organic substance;multi-organism process;peptidyl-serine modification;regulation of epithelial cell migration;embryo development;response to nutrient levels;negative regulation of striated muscle tissue development;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;embryonic hemopoiesis;leukocyte activation;morphogenesis of a branching structure;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;blood vessel development;patterning of blood vessels;common-partner SMAD protein phosphorylation;organ morphogenesis;regulation of developmental process;regulation of catalytic activity;regulation of transforming growth factor beta receptor signaling pathway;tissue development;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;endocytosis;smoothened signaling pathway;regulation of epithelial to mesenchymal transition;response to stimulus;receptor-mediated endocytosis;regulation of transferase activity;regulation of leukocyte activation;positive regulation of leukocyte activation;regulation of cell motility;positive regulation of cell motility;camera-type eye development;myeloid dendritic cell differentiation;negative regulation of multicellular organismal process;regulation of response to external stimulus;vasculature development;negative regulation of cellular response to growth factor stimulus;digestive system development;skeletal muscle tissue regeneration;cellular response to chemical stimulus;reproduction;single-organism process;regulation of cellular response to growth factor stimulus;regulation of lymphocyte activation;positive regulation of multicellular organismal process;regulation of anatomical structure morphogenesis;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of leukocyte cell-cell adhesion;regulation of cell morphogenesis involved in differentiation;NK T cell differentiation;regulation of protein modification process;regulation of response to wounding;positive regulation of response to wounding;regulation of leukocyte cell-cell adhesion;locomotion;reactive oxygen species metabolic process;regulation of cellular component movement;epithelium migration;tissue migration;response to drug;cardiac muscle tissue development;localization of cell;regulation of lymphocyte differentiation;system development;gland development;cardiac muscle tissue growth;respiratory tube development;lung development;regulation of cell activation;positive regulation of cell activation;regulation of T cell activation;striated muscle tissue development;angiogenesis;negative regulation of cellular response to transforming growth factor beta stimulus;regulation of cellular response to transforming growth factor beta stimulus;lung morphogenesis;regulation of leukocyte differentiation;cardiac muscle cell proliferation;positive regulation of phosphate metabolic process;morphogenesis of a branching epithelium;regulation of organ growth;negative regulation of organ growth;reproductive process;T cell aggregation;response to estrogen;response to chemical;tube development;leukocyte aggregation;positive regulation of tolerance induction to self antigen;response to abiotic stimulus;response to carbohydrate;regulation of cell differentiation;cellular metabolic process;response to glucose;muscle tissue development;regulation of phosphate metabolic process;regulation of metabolic process;developmental cell growth;negative regulation of response to stimulus;positive regulation of response to stimulus;cell development;circulatory system development;cardiovascular system development;cellular component organization or biogenesis;Notch signaling pathway;stem cell development;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;animal organ development;blood vessel morphogenesis;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;endochondral bone growth;growth plate cartilage development;chondrocyte differentiation involved in endochondral bone morphogenesis;regulation of cell proliferation;mesenchymal cell differentiation;transforming growth factor beta receptor signaling pathway;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;tolerance induction;single organism reproductive process;vesicle-mediated transport;single-multicellular organism process;multi-multicellular organism process;myeloid leukocyte activation;organ formation;immune system process;muscle cell proliferation;anatomical structure formation involved in morphogenesis;response to hormone;regulation of cell morphogenesis;positive regulation of kinase activity;movement of cell or subcellular component;negative regulation of muscle tissue development;negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of kinase activity;negative regulation of developmental growth;cell migration;mammary gland development;transport;negative regulation of cardiac muscle tissue development;negative regulation of cardiac muscle tissue growth;regulation of cardiac muscle tissue development;cranial skeletal system development;positive regulation of T cell tolerance induction;regulation of cardiac muscle tissue growth;cell activation;myeloid dendritic cell activation;stem cell proliferation;regulation of B cell tolerance induction;vasculogenesis;brain development;sensory organ development;programmed cell death;regulation of response to stress;positive regulation of protein modification process;response to stress;gastrulation;regulation of cell adhesion;cell differentiation;negative regulation of cardiac muscle cell proliferation;positive regulation of T cell differentiation;response to mechanical stimulus;regulation of cardiac muscle cell proliferation;muscle structure development;single organismal cell-cell adhesion;in utero embryonic development;trachea formation;mammary gland morphogenesis;positive regulation of cellular protein metabolic process;epithelial tube morphogenesis;chordate embryonic development;developmental growth involved in morphogenesis;dendritic cell differentiation;developmental process;multicellular organismal process;cellular process;regulation of localization;cellular response to growth factor stimulus;response to hexose;positive regulation of lymphocyte activation;cellular response to transforming growth factor beta stimulus;positive regulation of cell morphogenesis involved in differentiation;response to steroid hormone;branching morphogenesis of an epithelial tube;positive regulation of epithelial cell migration;pattern specification process;regulation of angiogenesis;positive regulation of angiogenesis;myeloid leukocyte differentiation;organic substance metabolic process;cellular response to organic substance;tissue morphogenesis;positive regulation of cell migration;regulation of cell migration;response to nutrient;apoptotic process;connective tissue development;regulation of phosphorus metabolic process;response to sterol;localization;primary metabolic process;regulation of primary metabolic process;positive regulation of alpha-beta T cell differentiation;regulation of alpha-beta T cell differentiation;positive regulation of alpha-beta T cell activation;regulation of alpha-beta T cell activation;alpha-beta T cell differentiation;alpha-beta T cell activation;organ growth;regulation of T cell tolerance induction;muscle organ development;response to cholesterol;positive regulation of macromolecule metabolic process;positive regulation of B cell tolerance induction;response to wounding;peptidyl-amino acid modification;negative regulation of transforming growth factor beta receptor signaling pathway;regulation of macromolecule metabolic process;regulation of muscle tissue development;lymphocyte activation;hematopoietic or lymphoid organ development;regulation of T cell differentiation;cartilage development;cell motility;tissue regeneration;response to transforming growth factor beta;heart growth;cell growth;positive regulation of reactive oxygen species metabolic process;pathway-restricted SMAD protein phosphorylation;cellular component organization;biological regulation;positive regulation of stem cell proliferation;regulation of molecular function;lymphocyte aggregation;positive regulation of cellular component organization;response to endogenous stimulus;regulation of NK T cell differentiation;positive regulation of NK T cell differentiation;wound healing;protein modification process;biological_process;metabolic process;smooth muscle cell proliferation;phosphorylation;embryo development ending in birth or egg hatching;signaling;negative regulation of cell communication;regulation of signaling;ameboidal-type cell migration;anatomical structure morphogenesis;positive regulation of catalytic activity;central nervous system development;gland morphogenesis;biological adhesion;endochondral bone morphogenesis;cartilage development involved in endochondral bone morphogenesis;regulation of heart growth;heart development;epithelium development;positive regulation of cell differentiation;negative regulation of heart growth;negative regulation of developmental process;regulation of cellular protein metabolic process;aging;nervous system development;positive regulation of developmental process;female pregnancy;embryo implantation;macromolecule metabolic process;lymphocyte differentiation;myeloid cell differentiation;hemopoiesis;positive regulation of protein kinase activity;cellular response to endogenous stimulus;response to extracellular stimulus;positive regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of wound healing;morphogenesis of an epithelium;growth;regulation of growth;regulation of mesenchymal cell proliferation;gene expression;mesenchymal cell proliferation;chondrocyte development involved in endochondral bone morphogenesis;growth plate cartilage chondrocyte growth;growth plate cartilage chondrocyte development;regulation of gene expression;regulation of smooth muscle cell proliferation;positive regulation of smooth muscle cell proliferation;homotypic cell-cell adhesion;positive regulation of phosphorus metabolic process;leukocyte cell-cell adhesion;cell adhesion;cell communication;regulation of protein phosphorylation;single organism cell adhesion;positive regulation of growth;positive regulation of protein phosphorylation; 5;5;3;6;3;8;5;5;5;3;7;7;7;6;3;6;4;4;5;4;3;4;5;2;5;6;5;3;3;4;4;5;6;6;5;4;5;5;6;5;5;6;3;6;5;4;4;4;5;4;6;5;7;4;5;6;6;5;4;4;4;3;6;5;5;5;4;4;8;5;8;3;5;5;4;5;4;5;6;4;4;4;4;4;5;5;5;4;7;8;6;3;3;5;4;4;3;3;3;5;5;4;4;3;5;3;3;6;6;9;4;5;6;4;4;4;4;4;4;5;5;4;6;5;5;6;3;4;4;4;2;8;4;5;5;5;5;5;3;4;5;4;4;4;5;8;4;3;4;6;4;3;3;3;6;6;5;2;7;5;4;4;4;4;6;6;3;4;5;4;5;5;4;2;2;4;5;3;4;5;5;6;6;8;6;5;4;6;2;4;4;5;4;4;5;3;6;4;4;4;4;4;4;4;6;6;4;5;5;5;5;5;6;5;4;4;2;4;6;3;4;6;5;3;5;4;3;8;5;6;3;4;3;3;4;5;5;2;6;5;4;4;4;4;4;5;2;2;6;5;5;4;6;6;7;3;3;3;5;3;3;4;4;2;4;3;4;5;7;4;4;5;6;4;4;5;4;6;5;6;4;5;5;4;5;4;5;5;4;4;5;4;6;3;5;4;5;5;7;4;5;4;4;8;5;6;5;5;7;4;7;2;2;2;3;6;7;5;5;5;5;5;4;4;5;5;7;3;5;4;5;5;4;6;5;5;6;2;3;4;8;8;7;7;7;6;4;5;5;7;4;5;4;7;6;4;4;4;4;7;5;3;4;4;5;3;5;8;3;2;5;3;7;4;3;9;9;5;5;1;2;5;6;6;2;4;3;5;3;5;5;5;2;6;4;5;4;5;4;5;3;5;4;5;3;4;4;4;5;6;5;8;4;4;4;4;5;5;2;3;6;5;5;6;5;7;5;5;5;5;5;5;3;4;7;3;3;7; GO:0044853;GO:0044424;GO:0044425;GO:0009897;GO:0070022;GO:0031226;GO:0044464;GO:0071944;GO:0005737;GO:0016021;GO:0016020;GO:1902494;GO:0098589;GO:1902554;GO:0043234;GO:0043235;GO:0005829;GO:1902911;GO:0098552;GO:0098857;GO:0098590;GO:0005622;GO:0044444;GO:0009986;GO:0005575;GO:0045121;GO:0098805;GO:1990234;GO:0061695;GO:0031224;GO:0005901;GO:0044459;GO:0005623;GO:0098802;GO:0005887;GO:0005886;GO:0032991;GO:0098797;GO:0098796; plasma membrane raft;intracellular part;membrane part;external side of plasma membrane;transforming growth factor beta receptor homodimeric complex;intrinsic component of plasma membrane;cell part;cell periphery;cytoplasm;integral component of membrane;membrane;catalytic complex;membrane region;serine/threonine protein kinase complex;protein complex;receptor complex;cytosol;protein kinase complex;side of membrane;membrane microdomain;plasma membrane region;intracellular;cytoplasmic part;cell surface;cellular_component;membrane raft;whole membrane;transferase complex;transferase complex, transferring phosphorus-containing groups;intrinsic component of membrane;caveola;plasma membrane part;cell;plasma membrane receptor complex;integral component of plasma membrane;plasma membrane;macromolecular complex;plasma membrane protein complex;membrane protein complex; 4;3;2;4;5;4;2;3;4;4;2;4;3;8;3;4;5;7;3;4;4;3;4;3;1;5;3;5;6;3;5;3;2;4;4;3;2;4;3; GO:0000166;GO:0046332;GO:0005102;GO:0005488;GO:1901265;GO:0017076;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0050431;GO:0046872;GO:0001883;GO:0001882;GO:0016740;GO:0004702;GO:0099600;GO:0036094;GO:0019955;GO:0005515;GO:0004675;GO:0004674;GO:0004672;GO:0060089;GO:1901363;GO:0003674;GO:0034714;GO:0019838;GO:0005524;GO:0016301;GO:0003824;GO:0034713;GO:0097159;GO:0043168;GO:0043169;GO:0043167;GO:0030554;GO:0005026;GO:0005024;GO:0005160;GO:0004888;GO:0097367;GO:0005126;GO:0032549;GO:0005539;GO:0035639;GO:0038023;GO:0004872;GO:0004871;GO:0005057;GO:0019199; nucleotide binding;SMAD binding;receptor binding;binding;nucleoside phosphate binding;purine nucleotide binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;transforming growth factor beta binding;metal ion binding;purine nucleoside binding;nucleoside binding;transferase activity;receptor signaling protein serine/threonine kinase activity;transmembrane receptor activity;small molecule binding;cytokine binding;protein binding;transmembrane receptor protein serine/threonine kinase activity;protein serine/threonine kinase activity;protein kinase activity;molecular transducer activity;heterocyclic compound binding;molecular_function;type III transforming growth factor beta receptor binding;growth factor binding;ATP binding;kinase activity;catalytic activity;type I transforming growth factor beta receptor binding;organic cyclic compound binding;anion binding;cation binding;ion binding;adenyl nucleotide binding;transforming growth factor beta receptor activity, type II;transforming growth factor beta-activated receptor activity;transforming growth factor beta receptor binding;transmembrane signaling receptor activity;carbohydrate derivative binding;cytokine receptor binding;ribonucleoside binding;glycosaminoglycan binding;purine ribonucleoside triphosphate binding;signaling receptor activity;receptor activity;signal transducer activity;receptor signaling protein activity;transmembrane receptor protein kinase activity; 4;4;4;2;4;5;5;4;6;5;6;4;5;5;5;4;3;4;4;3;4;3;6;7;6;2;3;1;7;4;6;5;2;7;3;4;4;3;6;8;7;6;4;3;5;5;4;5;3;3;2;3;5; K04388 map04010;map04060;map04068;map04144;map04350;map04380;map04390;map04520;map04933;map05142;map05166;map05200;map05202;map05210;map05212;map05220; MAPK signaling pathway;Cytokine-cytokine receptor interaction;FoxO signaling pathway;Endocytosis;TGF-beta signaling pathway;Osteoclast differentiation;Hippo signaling pathway;Adherens junction;AGE-RAGE signaling pathway in diabetic complications;Chagas disease (American trypanosomiasis);HTLV-I infection;Pathways in cancer;Transcriptional misregulation in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia; IPR000333;IPR011009;IPR000719;IPR017194;IPR001245;IPR008271;IPR017441;IPR015013; Ser/Thr protein kinase, TGFB receptor;Protein kinase-like domain;Protein kinase domain;Transforming growth factor-beta receptor, type II;Serine-threonine/tyrosine-protein kinase, catalytic domain;Serine/threonine-protein kinase, active site;Protein kinase, ATP binding site;Transforming growth factor beta receptor 2 ectodomain; mitochondria Hs19923238 1178.0 T [T] Signal transduction mechanisms; P01344 Insulin-like growth factor II OS=Homo sapiens OX=9606 GN=IGF2 PE=1 SV=1 - [IGF2_HUMAN] 1.082 1.004 0.927 1.062 1.002 1.446 1.077689243 0.306280177 1.05988024 0.60564666 0.923306773 0.216426593 1.443113772 0.116670135 GO:0007599;GO:0010564;GO:0007596;GO:0002707;GO:0001501;GO:0001503;GO:0002703;GO:0044281;GO:0051716;GO:0000003;GO:0000165;GO:0007088;GO:0045859;GO:0046483;GO:0042325;GO:0042327;GO:0071593;GO:0009605;GO:0002706;GO:0019538;GO:0010638;GO:0051783;GO:0051781;GO:0002704;GO:0051785;GO:0009893;GO:0009891;GO:0010906;GO:0010907;GO:0046651;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0051347;GO:0006887;GO:0002684;GO:0002682;GO:0071840;GO:0045913;GO:0018130;GO:2000273;GO:0098602;GO:0098609;GO:0019318;GO:0043410;GO:0043412;GO:0044723;GO:0044042;GO:0035094;GO:0010557;GO:0010556;GO:0097305;GO:0018212;GO:0051128;GO:0014070;GO:0000280;GO:0002228;GO:0008284;GO:0008286;GO:0050878;GO:0008283;GO:0050877;GO:0050870;GO:0034637;GO:0010675;GO:0010676;GO:0048519;GO:0015980;GO:0018108;GO:0022407;GO:0022402;GO:0006091;GO:0051302;GO:0051301;GO:0022409;GO:0032355;GO:0033993;GO:2000112;GO:0007275;GO:0070661;GO:0070663;GO:0070665;GO:0006468;GO:0045088;GO:0019219;GO:0045087;GO:0000271;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0032881;GO:0048856;GO:0002698;GO:0006796;GO:0006793;GO:0048522;GO:0034112;GO:0034110;GO:0007613;GO:0007610;GO:0007611;GO:0031348;GO:0007165;GO:0007166;GO:0007167;GO:0031341;GO:0007169;GO:0031342;GO:0031347;GO:0044710;GO:0044711;GO:0045787;GO:0045785;GO:0001909;GO:0044093;GO:0045953;GO:0001906;GO:2001141;GO:0010033;GO:0051704;GO:0031667;GO:1900076;GO:1900078;GO:0045840;GO:0045321;GO:0006807;GO:0000278;GO:0044267;GO:0044264;GO:0044262;GO:0044260;GO:0042098;GO:0045824;GO:0044699;GO:0050798;GO:2000467;GO:2000465;GO:0050790;GO:0009889;GO:0050794;GO:0051234;GO:0042269;GO:0050896;GO:0042267;GO:0050890;GO:0051338;GO:0002694;GO:0002697;GO:0002696;GO:0006109;GO:0010562;GO:0051171;GO:0033043;GO:0009314;GO:0009250;GO:0070887;GO:0032885;GO:0007049;GO:0043408;GO:0051249;GO:0071375;GO:0051246;GO:0051247;GO:1903039;GO:0031399;GO:1903037;GO:0007565;GO:0043279;GO:0042493;GO:0033692;GO:0048731;GO:0016337;GO:0050865;GO:0050867;GO:0050863;GO:1901360;GO:0045931;GO:0045937;GO:0046626;GO:0045471;GO:0070489;GO:0043627;GO:0071514;GO:0070486;GO:0006996;GO:0044238;GO:0005975;GO:0005977;GO:0005976;GO:0005979;GO:0005978;GO:0044237;GO:0019220;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:1901362;GO:0010962;GO:0009966;GO:0009967;GO:0040029;GO:0006073;GO:0048518;GO:0006112;GO:0002683;GO:0042127;GO:0042129;GO:0042221;GO:0043434;GO:0070873;GO:0070875;GO:0055114;GO:0003008;GO:0044700;GO:0044703;GO:0016192;GO:0044707;GO:0044706;GO:0050731;GO:0044708;GO:0010243;GO:0016051;GO:0002376;GO:0001911;GO:0001910;GO:0005996;GO:0046006;GO:0033674;GO:0071260;GO:0097659;GO:0090068;GO:0043549;GO:0045055;GO:0045725;GO:0071214;GO:0006810;GO:0006952;GO:0006950;GO:0050817;GO:0006955;GO:0034654;GO:1902533;GO:1902531;GO:0046903;GO:0044271;GO:0080134;GO:0031401;GO:0001775;GO:0006355;GO:0006351;GO:0032774;GO:0030155;GO:0018193;GO:0006139;GO:0032270;GO:0071495;GO:0016070;GO:0071496;GO:0009987;GO:0006725;GO:1903506;GO:0032870;GO:0050777;GO:0050776;GO:0051251;GO:0051252;GO:0050670;GO:0050671;GO:0006006;GO:0048545;GO:0042110;GO:0043467;GO:0002576;GO:0071704;GO:0071310;GO:0050730;GO:0051174;GO:0009058;GO:0009059;GO:0002715;GO:0002716;GO:0051179;GO:1902578;GO:0051726;GO:1902589;GO:1901652;GO:1901653;GO:0080090;GO:0051897;GO:0051896;GO:0023014;GO:0010604;GO:0009611;GO:0009612;GO:0060255;GO:0046649;GO:0030168;GO:0019438;GO:0046628;GO:0032943;GO:0032940;GO:0032946;GO:0032944;GO:0007067;GO:1901576;GO:0007346;GO:0016043;GO:0065007;GO:0042104;GO:0065009;GO:0065008;GO:0051130;GO:0009719;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0043255;GO:0022414;GO:0043491;GO:1901698;GO:1901699;GO:0016310;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043085;GO:0006349;GO:0022610;GO:0009628;GO:0032268;GO:0009725;GO:0043170;GO:0045860;GO:0032502;GO:0009991;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:1903047;GO:0038028;GO:0090304;GO:0032501;GO:0032869;GO:0032868;GO:0071417;GO:0010467;GO:0010469;GO:0010468;GO:0034109;GO:0042102;GO:0002449;GO:0007159;GO:0007155;GO:0007154;GO:0002443;GO:0048285;GO:0002252;GO:0001932;GO:0001934; hemostasis;regulation of cell cycle process;blood coagulation;negative regulation of lymphocyte mediated immunity;skeletal system development;ossification;regulation of leukocyte mediated immunity;small molecule metabolic process;cellular response to stimulus;reproduction;MAPK cascade;regulation of mitotic nuclear division;regulation of protein kinase activity;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;lymphocyte aggregation;response to external stimulus;regulation of lymphocyte mediated immunity;protein metabolic process;positive regulation of organelle organization;regulation of nuclear division;positive regulation of cell division;negative regulation of leukocyte mediated immunity;positive regulation of nuclear division;positive regulation of metabolic process;positive regulation of biosynthetic process;regulation of glucose metabolic process;positive regulation of glucose metabolic process;lymphocyte proliferation;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;positive regulation of transferase activity;exocytosis;positive regulation of immune system process;regulation of immune system process;cellular component organization or biogenesis;positive regulation of carbohydrate metabolic process;heterocycle biosynthetic process;positive regulation of receptor activity;single organism cell adhesion;cell-cell adhesion;hexose metabolic process;positive regulation of MAPK cascade;macromolecule modification;single-organism carbohydrate metabolic process;glucan metabolic process;response to nicotine;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;response to alcohol;peptidyl-tyrosine modification;regulation of cellular component organization;response to organic cyclic compound;nuclear division;natural killer cell mediated immunity;positive regulation of cell proliferation;insulin receptor signaling pathway;regulation of body fluid levels;cell proliferation;neurological system process;positive regulation of T cell activation;cellular carbohydrate biosynthetic process;regulation of cellular carbohydrate metabolic process;positive regulation of cellular carbohydrate metabolic process;negative regulation of biological process;energy derivation by oxidation of organic compounds;peptidyl-tyrosine phosphorylation;regulation of cell-cell adhesion;cell cycle process;generation of precursor metabolites and energy;regulation of cell division;cell division;positive regulation of cell-cell adhesion;response to estradiol;response to lipid;regulation of cellular macromolecule biosynthetic process;multicellular organism development;leukocyte proliferation;regulation of leukocyte proliferation;positive regulation of leukocyte proliferation;protein phosphorylation;regulation of innate immune response;regulation of nucleobase-containing compound metabolic process;innate immune response;polysaccharide biosynthetic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;regulation of polysaccharide metabolic process;anatomical structure development;negative regulation of immune effector process;phosphate-containing compound metabolic process;phosphorus metabolic process;positive regulation of cellular process;positive regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;memory;behavior;learning or memory;negative regulation of defense response;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of cell killing;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of cell killing;regulation of defense response;single-organism metabolic process;single-organism biosynthetic process;positive regulation of cell cycle;positive regulation of cell adhesion;leukocyte mediated cytotoxicity;positive regulation of molecular function;negative regulation of natural killer cell mediated cytotoxicity;cell killing;regulation of RNA biosynthetic process;response to organic substance;multi-organism process;response to nutrient levels;regulation of cellular response to insulin stimulus;positive regulation of cellular response to insulin stimulus;positive regulation of mitotic nuclear division;leukocyte activation;nitrogen compound metabolic process;mitotic cell cycle;cellular protein metabolic process;cellular polysaccharide metabolic process;cellular carbohydrate metabolic process;cellular macromolecule metabolic process;T cell proliferation;negative regulation of innate immune response;single-organism process;activated T cell proliferation;positive regulation of glycogen (starch) synthase activity;regulation of glycogen (starch) synthase activity;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;establishment of localization;regulation of natural killer cell mediated cytotoxicity;response to stimulus;natural killer cell mediated cytotoxicity;cognition;regulation of transferase activity;regulation of leukocyte activation;regulation of immune effector process;positive regulation of leukocyte activation;regulation of carbohydrate metabolic process;positive regulation of phosphorus metabolic process;regulation of nitrogen compound metabolic process;regulation of organelle organization;response to radiation;glucan biosynthetic process;cellular response to chemical stimulus;regulation of polysaccharide biosynthetic process;cell cycle;regulation of MAPK cascade;regulation of lymphocyte activation;cellular response to peptide hormone stimulus;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of leukocyte cell-cell adhesion;regulation of protein modification process;regulation of leukocyte cell-cell adhesion;female pregnancy;response to alkaloid;response to drug;cellular polysaccharide biosynthetic process;system development;single organismal cell-cell adhesion;regulation of cell activation;positive regulation of cell activation;regulation of T cell activation;organic cyclic compound metabolic process;positive regulation of mitotic cell cycle;positive regulation of phosphate metabolic process;regulation of insulin receptor signaling pathway;response to ethanol;T cell aggregation;response to estrogen;genetic imprinting;leukocyte aggregation;organelle organization;primary metabolic process;carbohydrate metabolic process;glycogen metabolic process;polysaccharide metabolic process;regulation of glycogen biosynthetic process;glycogen biosynthetic process;cellular metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;organic cyclic compound biosynthetic process;regulation of glucan biosynthetic process;regulation of signal transduction;positive regulation of signal transduction;regulation of gene expression, epigenetic;cellular glucan metabolic process;positive regulation of biological process;energy reserve metabolic process;negative regulation of immune system process;regulation of cell proliferation;regulation of T cell proliferation;response to chemical;response to peptide hormone;regulation of glycogen metabolic process;positive regulation of glycogen metabolic process;oxidation-reduction process;system process;single organism signaling;multi-organism reproductive process;vesicle-mediated transport;single-multicellular organism process;multi-multicellular organism process;positive regulation of peptidyl-tyrosine phosphorylation;single-organism behavior;response to organonitrogen compound;carbohydrate biosynthetic process;immune system process;negative regulation of leukocyte mediated cytotoxicity;regulation of leukocyte mediated cytotoxicity;monosaccharide metabolic process;regulation of activated T cell proliferation;positive regulation of kinase activity;cellular response to mechanical stimulus;nucleic acid-templated transcription;positive regulation of cell cycle process;regulation of kinase activity;regulated exocytosis;positive regulation of glycogen biosynthetic process;cellular response to abiotic stimulus;transport;defense response;response to stress;coagulation;immune response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;secretion;cellular nitrogen compound biosynthetic process;regulation of response to stress;positive regulation of protein modification process;cell activation;regulation of transcription, DNA-templated;transcription, DNA-templated;RNA biosynthetic process;regulation of cell adhesion;peptidyl-amino acid modification;nucleobase-containing compound metabolic process;positive regulation of cellular protein metabolic process;cellular response to endogenous stimulus;RNA metabolic process;cellular response to external stimulus;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to hormone stimulus;negative regulation of immune response;regulation of immune response;positive regulation of lymphocyte activation;regulation of RNA metabolic process;regulation of lymphocyte proliferation;positive regulation of lymphocyte proliferation;glucose metabolic process;response to steroid hormone;T cell activation;regulation of generation of precursor metabolites and energy;platelet degranulation;organic substance metabolic process;cellular response to organic substance;regulation of peptidyl-tyrosine phosphorylation;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of natural killer cell mediated immunity;negative regulation of natural killer cell mediated immunity;localization;single-organism localization;regulation of cell cycle;single-organism organelle organization;response to peptide;cellular response to peptide;regulation of primary metabolic process;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;signal transduction by protein phosphorylation;positive regulation of macromolecule metabolic process;response to wounding;response to mechanical stimulus;regulation of macromolecule metabolic process;lymphocyte activation;platelet activation;aromatic compound biosynthetic process;positive regulation of insulin receptor signaling pathway;mononuclear cell proliferation;secretion by cell;positive regulation of mononuclear cell proliferation;regulation of mononuclear cell proliferation;mitotic nuclear division;organic substance biosynthetic process;regulation of mitotic cell cycle;cellular component organization;biological regulation;positive regulation of activated T cell proliferation;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;response to endogenous stimulus;wound healing;protein modification process;biological_process;metabolic process;regulation of carbohydrate biosynthetic process;reproductive process;protein kinase B signaling;response to nitrogen compound;cellular response to nitrogen compound;phosphorylation;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;positive regulation of catalytic activity;regulation of gene expression by genetic imprinting;biological adhesion;response to abiotic stimulus;regulation of cellular protein metabolic process;response to hormone;macromolecule metabolic process;positive regulation of protein kinase activity;developmental process;response to extracellular stimulus;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;insulin receptor signaling pathway via phosphatidylinositol 3-kinase;nucleic acid metabolic process;multicellular organismal process;cellular response to insulin stimulus;response to insulin;cellular response to organonitrogen compound;gene expression;regulation of receptor activity;regulation of gene expression;homotypic cell-cell adhesion;positive regulation of T cell proliferation;lymphocyte mediated immunity;leukocyte cell-cell adhesion;cell adhesion;cell communication;leukocyte mediated immunity;organelle fission;immune effector process;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 5;5;5;6;5;4;5;4;3;2;5;6;7;4;7;7;7;3;6;4;5;5;4;5;5;3;4;6;6;5;9;5;8;2;6;5;3;3;2;4;5;5;3;4;6;6;5;4;6;6;5;5;5;8;4;5;6;5;4;8;4;3;4;6;4;5;5;2;4;8;5;4;4;4;4;5;6;5;6;4;4;5;5;7;5;5;4;6;6;3;4;3;4;5;5;3;4;5;4;3;6;6;5;2;4;4;4;5;6;3;7;3;5;3;4;4;4;3;4;4;2;6;4;2;5;4;4;6;3;3;5;5;5;4;4;6;5;2;7;7;6;4;4;3;3;4;2;3;5;5;4;4;4;5;5;4;5;4;6;4;6;4;6;5;6;5;5;6;6;6;4;5;4;5;4;4;4;4;6;4;5;6;5;6;4;6;5;6;4;3;4;5;5;7;6;3;6;3;3;3;3;5;6;4;4;6;6;2;5;3;4;7;3;5;6;5;4;3;3;3;5;3;3;8;3;4;5;2;4;4;5;8;7;5;7;5;6;6;6;4;4;4;3;4;3;5;5;5;5;5;4;6;4;6;6;6;4;7;4;5;4;5;4;2;4;7;5;4;4;5;5;6;6;7;5;5;5;7;3;5;8;5;3;5;6;6;2;3;4;4;5;6;4;6;6;4;4;4;4;4;4;5;5;5;5;4;6;6;5;4;5;3;2;8;3;3;4;3;5;5;1;2;5;2;6;4;5;6;3;4;4;2;5;3;4;4;5;6;2;3;5;4;4;8;2;4;5;5;4;4;5;9;5;2;7;6;5;5;4;5;5;7;5;5;3;4;4;5;3;7;7; GO:0034774;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0071944;GO:0070062;GO:0005615;GO:0016023;GO:0016020;GO:0099503;GO:0043230;GO:0043231;GO:0043233;GO:0044433;GO:0030141;GO:0060205;GO:0031091;GO:0031093;GO:0031974;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0005737;GO:0031983;GO:0031988;GO:0097708;GO:1903561;GO:0031410;GO:0005623;GO:0005886;GO:0005575;GO:0005576; secretory granule lumen;intracellular part;extracellular region part;organelle part;cell part;cell periphery;extracellular exosome;extracellular space;cytoplasmic, membrane-bounded vesicle;membrane;secretory vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytoplasmic vesicle part;secretory granule;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;platelet alpha granule lumen;membrane-enclosed lumen;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;cytoplasm;vesicle lumen;membrane-bounded vesicle;intracellular vesicle;extracellular vesicle;cytoplasmic vesicle;cell;plasma membrane;cellular_component;extracellular region; 5;3;2;2;2;3;4;3;5;2;6;3;4;3;4;4;5;5;6;2;3;3;3;2;3;4;3;4;4;4;5;4;3;5;2;3;1;2; GO:0098772;GO:0030295;GO:0005488;GO:0019887;GO:0008083;GO:0030545;GO:0030546;GO:0032403;GO:0005515;GO:0005102;GO:0008047;GO:0005159;GO:0005158;GO:0003674;GO:0030234;GO:0044877;GO:0043539;GO:0019207;GO:0019209; molecular function regulator;protein kinase activator activity;binding;protein kinase regulator activity;growth factor activity;receptor regulator activity;receptor activator activity;protein complex binding;protein binding;receptor binding;enzyme activator activity;insulin-like growth factor receptor binding;insulin receptor binding;molecular_function;enzyme regulator activity;macromolecular complex binding;protein serine/threonine kinase activator activity;kinase regulator activity;kinase activator activity; 2;6;2;5;5;3;4;4;3;4;4;5;5;1;3;3;7;4;5; K13769 map05205; Proteoglycans in cancer; IPR022352;IPR016179;IPR022334;IPR013576;IPR022353;IPR022350; Insulin family;Insulin-like;Insulin-like growth factor II;Insulin-like growth factor II E-peptide, C-terminal;Insulin, conserved site;Insulin-like growth factor; extracellular P01876 Immunoglobulin heavy constant alpha 1 OS=Homo sapiens OX=9606 GN=IGHA1 PE=1 SV=2 - [IGHA1_HUMAN] 0.924 1.131 0.873 0.922 1.207 0.818 0.816976127 5.73E-68 0.763877382 2.37E-77 0.771883289 1.54E-41 0.677713339 3.86E-13 GO:0006909;GO:0019730;GO:0019731;GO:0048584;GO:0048583;GO:0061024;GO:0003014;GO:0007165;GO:0007166;GO:0002455;GO:0044707;GO:0071840;GO:0044710;GO:0043207;GO:0003094;GO:0048518;GO:0065007;GO:0051704;GO:0019724;GO:0046649;GO:0006910;GO:0009607;GO:0051707;GO:0003008;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0048871;GO:0002376;GO:0060263;GO:0009893;GO:0060267;GO:0045321;GO:0042742;GO:0050789;GO:0044267;GO:0002764;GO:0044260;GO:0002768;GO:0002684;GO:0002682;GO:0060249;GO:0065008;GO:0006956;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0002757;GO:0006897;GO:0043412;GO:0050896;GO:0006898;GO:0001775;GO:0002694;GO:0045730;GO:0016064;GO:0009617;GO:0023052;GO:0044699;GO:0016043;GO:0051249;GO:0008037;GO:0032501;GO:0009987;GO:0050871;GO:0098542;GO:0001894;GO:0001895;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0043170;GO:0010324;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0042592;GO:0051234;GO:0097205;GO:0072376;GO:0002443;GO:0071704;GO:0002696;GO:0050851;GO:0050853;GO:0045087;GO:0018298;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0019222;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0002250;GO:0002253;GO:0002252;GO:0048522; phagocytosis;antimicrobial humoral response;antibacterial humoral response;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;renal system process;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;single-multicellular organism process;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;glomerular filtration;positive regulation of biological process;biological regulation;multi-organism process;B cell mediated immunity;lymphocyte activation;phagocytosis, recognition;response to biotic stimulus;response to other organism;system process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;multicellular organismal homeostasis;immune system process;regulation of respiratory burst;positive regulation of metabolic process;positive regulation of respiratory burst;leukocyte activation;defense response to bacterium;regulation of biological process;cellular protein metabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;immune response-regulating cell surface receptor signaling pathway;positive regulation of immune system process;regulation of immune system process;anatomical structure homeostasis;regulation of biological quality;complement activation;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;protein modification process;biological_process;cellular protein modification process;metabolic process;immune response;complement activation, classical pathway;humoral immune response;immune response-activating signal transduction;endocytosis;macromolecule modification;response to stimulus;receptor-mediated endocytosis;cell activation;regulation of leukocyte activation;respiratory burst;immunoglobulin mediated immune response;response to bacterium;signaling;single-organism process;cellular component organization;regulation of lymphocyte activation;cell recognition;multicellular organismal process;cellular process;positive regulation of B cell activation;defense response to other organism;tissue homeostasis;retina homeostasis;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;macromolecule metabolic process;membrane invagination;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;homeostatic process;establishment of localization;renal filtration;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;positive regulation of leukocyte activation;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;protein-chromophore linkage;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;regulation of metabolic process;localization;single-organism localization;primary metabolic process;cellular metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of cellular process; 5;4;5;3;3;4;4;4;5;5;3;2;3;4;6;2;2;2;6;4;5;3;3;3;3;5;5;3;4;4;2;4;3;4;3;5;2;5;5;4;6;3;3;5;3;4;4;3;3;4;3;5;1;6;2;3;5;4;4;6;5;2;7;4;4;4;7;4;2;2;3;5;4;2;2;6;4;5;6;4;5;5;4;4;5;4;6;4;5;4;3;5;3;4;3;4;6;7;4;7;6;5;4;3;4;3;2;3;3;3;4;3;3;3; GO:0031982;GO:0005615;GO:0016020;GO:0043234;GO:0043230;GO:0071752;GO:0044425;GO:0071750;GO:0071751;GO:0044421;GO:0009897;GO:0043227;GO:0072562;GO:0071749;GO:0071748;GO:0071745;GO:0071746;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576; vesicle;extracellular space;membrane;protein complex;extracellular organelle;secretory dimeric IgA immunoglobulin complex;membrane part;dimeric IgA immunoglobulin complex;secretory IgA immunoglobulin complex;extracellular region part;external side of plasma membrane;membrane-bounded organelle;blood microparticle;polymeric IgA immunoglobulin complex;monomeric IgA immunoglobulin complex;IgA immunoglobulin complex;IgA immunoglobulin complex, circulating;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell;cell periphery;side of membrane;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region; 4;3;2;3;3;7;2;6;6;2;4;3;3;5;5;5;4;3;4;3;3;2;2;3;3;2;3;3;4;2;1;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular P01877 Immunoglobulin heavy constant alpha 2 OS=Homo sapiens OX=9606 GN=IGHA2 PE=1 SV=4 - [IGHA2_HUMAN] 0.889 1.014 1.11 0.917 1.054 0.928 0.876725838 2.35E-15 0.870018975 4.75E-12 1.094674556 0.002252019 0.880455408 1.38E-05 GO:0006909;GO:0019730;GO:0019731;GO:0048584;GO:0048583;GO:0061024;GO:0003014;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0009617;GO:0003094;GO:0048518;GO:0065007;GO:0051704;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0003008;GO:0044700;GO:0002429;GO:0044707;GO:0048871;GO:0019538;GO:0002376;GO:0060263;GO:0009893;GO:0060267;GO:0045321;GO:0042742;GO:0050789;GO:0002764;GO:0002768;GO:0002684;GO:0002682;GO:0060249;GO:0065008;GO:0006956;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0051249;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0051234;GO:0002757;GO:0006897;GO:0050896;GO:0006898;GO:0001775;GO:0002694;GO:0045730;GO:0016064;GO:0023052;GO:0044699;GO:0016043;GO:0006959;GO:0008037;GO:0032501;GO:0009987;GO:0050871;GO:0098542;GO:0001894;GO:0001895;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0043170;GO:0010324;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0042592;GO:0097205;GO:0072376;GO:0002443;GO:0071704;GO:0002696;GO:0009605;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0019222;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0048522;GO:0016192; phagocytosis;antimicrobial humoral response;antibacterial humoral response;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;renal system process;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;response to bacterium;glomerular filtration;positive regulation of biological process;biological regulation;multi-organism process;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;system process;single organism signaling;immune response-activating cell surface receptor signaling pathway;single-multicellular organism process;multicellular organismal homeostasis;protein metabolic process;immune system process;regulation of respiratory burst;positive regulation of metabolic process;positive regulation of respiratory burst;leukocyte activation;defense response to bacterium;regulation of biological process;immune response-regulating signaling pathway;immune response-regulating cell surface receptor signaling pathway;positive regulation of immune system process;regulation of immune system process;anatomical structure homeostasis;regulation of biological quality;complement activation;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;regulation of lymphocyte activation;biological_process;metabolic process;immune response;complement activation, classical pathway;establishment of localization;immune response-activating signal transduction;endocytosis;response to stimulus;receptor-mediated endocytosis;cell activation;regulation of leukocyte activation;respiratory burst;immunoglobulin mediated immune response;signaling;single-organism process;cellular component organization;humoral immune response;cell recognition;multicellular organismal process;cellular process;positive regulation of B cell activation;defense response to other organism;tissue homeostasis;retina homeostasis;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;macromolecule metabolic process;membrane invagination;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;homeostatic process;renal filtration;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;positive regulation of leukocyte activation;response to external stimulus;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;regulation of metabolic process;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of cellular process;vesicle-mediated transport; 5;4;5;3;3;4;4;4;5;5;2;3;4;4;6;2;2;2;6;4;3;3;3;3;5;3;4;4;2;4;3;4;3;5;2;5;6;3;3;5;3;4;4;3;3;4;3;5;1;2;3;5;3;4;6;2;7;4;4;4;7;2;2;3;4;4;2;2;6;4;5;6;4;5;5;4;4;5;4;6;4;5;4;5;3;4;3;4;3;6;7;4;5;6;5;4;3;4;3;2;3;3;4;3;3;3;5; GO:0031982;GO:0005615;GO:0043234;GO:0043230;GO:0071752;GO:0044425;GO:0071750;GO:0071751;GO:0044421;GO:0009897;GO:0043227;GO:0072562;GO:0071749;GO:0071748;GO:0071745;GO:0071746;GO:0016020;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576; vesicle;extracellular space;protein complex;extracellular organelle;secretory dimeric IgA immunoglobulin complex;membrane part;dimeric IgA immunoglobulin complex;secretory IgA immunoglobulin complex;extracellular region part;external side of plasma membrane;membrane-bounded organelle;blood microparticle;polymeric IgA immunoglobulin complex;monomeric IgA immunoglobulin complex;IgA immunoglobulin complex;IgA immunoglobulin complex, circulating;membrane;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell;cell periphery;side of membrane;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region; 4;3;3;3;7;2;6;6;2;4;3;3;5;5;5;4;2;3;4;3;3;2;2;3;3;2;3;3;4;2;1;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003006;IPR013783;IPR013151;IPR003597;IPR007110; Immunoglobulin/major histocompatibility complex, conserved site;Immunoglobulin-like fold;Immunoglobulin;Immunoglobulin C1-set;Immunoglobulin-like domain; nucleus Q9NPH3 Interleukin-1 receptor accessory protein OS=Homo sapiens OX=9606 GN=IL1RAP PE=1 SV=2 - [IL1AP_HUMAN] 0.853 0.824 1.319 1.049 1.01 1.298 1.035194175 nan 1.038613861 nan 1.600728155 nan 1.285148515 nan GO:0022607;GO:0070271;GO:0043933;GO:0006955;GO:0071840;GO:0002376;GO:0071822;GO:0016043;GO:0065003;GO:0006461;GO:0045087;GO:0009987;GO:0006952;GO:0006950;GO:0008150;GO:0006954;GO:0050896;GO:0044085; cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;immune response;cellular component organization or biogenesis;immune system process;protein complex subunit organization;cellular component organization;macromolecular complex assembly;protein complex assembly;innate immune response;cellular process;defense response;response to stress;biological_process;inflammatory response;response to stimulus;cellular component biogenesis; 4;4;4;3;2;2;5;3;5;5;4;2;4;3;1;5;2;3; GO:0005887;GO:0071944;GO:0031226;GO:0005737;GO:0016021;GO:0016020;GO:0005576;GO:0031224;GO:0044459;GO:0005886;GO:0043234;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044425; integral component of plasma membrane;cell periphery;intrinsic component of plasma membrane;cytoplasm;integral component of membrane;membrane;extracellular region;intrinsic component of membrane;plasma membrane part;plasma membrane;protein complex;macromolecular complex;cell part;cell;intracellular;cellular_component;intracellular part;membrane part; 4;3;4;4;4;2;2;3;3;3;3;2;2;2;3;1;3;2; GO:0038023;GO:0060089;GO:0003674;GO:0004872;GO:0004871;GO:0004896;GO:0004908;GO:0004888;GO:0099600; signaling receptor activity;molecular transducer activity;molecular_function;receptor activity;signal transducer activity;cytokine receptor activity;interleukin-1 receptor activity;transmembrane signaling receptor activity;transmembrane receptor activity; 3;2;1;3;2;5;6;4;4; K04723 map04060;map04750; Cytokine-cytokine receptor interaction;Inflammatory mediator regulation of TRP channels; IPR003599;IPR007110;IPR013783;IPR000157;IPR004074;IPR015621; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Toll/interleukin-1 receptor homology (TIR) domain;Interleukin-1 receptor type I/II;Interleukin-1 receptor family; peroxisome P01871 Immunoglobulin heavy constant mu OS=Homo sapiens OX=9606 GN=IGHM PE=1 SV=4 - [IGHM_HUMAN] 1.078 1.076 0.814 1.08 1.122 0.955 1.001858736 0.094715994 0.962566845 0.003300976 0.756505576 2.62E-50 0.851158645 0.00093661 GO:0006909;GO:0019730;GO:0019731;GO:0048584;GO:0048583;GO:0061024;GO:0007166;GO:0002455;GO:0071840;GO:0051716;GO:0043207;GO:0009617;GO:0048518;GO:0065007;GO:0019724;GO:0046649;GO:0051707;GO:0050794;GO:0051704;GO:0044700;GO:0002429;GO:0009607;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0007165;GO:0045321;GO:0050829;GO:0002764;GO:0002768;GO:0016043;GO:0002684;GO:0002682;GO:0044699;GO:0006810;GO:0044710;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0006955;GO:0006958;GO:0006959;GO:0002757;GO:0006897;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0006956;GO:0008152;GO:0023052;GO:0051234;GO:0008037;GO:0009987;GO:0050871;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0042742;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0072376;GO:0002443;GO:0050789;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522; phagocytosis;antimicrobial humoral response;antibacterial humoral response;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;cellular response to stimulus;response to external biotic stimulus;response to bacterium;positive regulation of biological process;biological regulation;B cell mediated immunity;lymphocyte activation;response to other organism;regulation of cellular process;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;response to biotic stimulus;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;signal transduction;leukocyte activation;defense response to Gram-negative bacterium;immune response-regulating signaling pathway;immune response-regulating cell surface receptor signaling pathway;cellular component organization;positive regulation of immune system process;regulation of immune system process;single-organism process;transport;single-organism metabolic process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;immune response;complement activation, classical pathway;humoral immune response;immune response-activating signal transduction;endocytosis;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;metabolic process;signaling;establishment of localization;cell recognition;cellular process;positive regulation of B cell activation;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;defense response to bacterium;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;protein activation cascade;leukocyte mediated immunity;regulation of biological process;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process; 5;4;5;3;3;4;5;5;2;3;4;4;2;2;6;4;3;3;2;3;5;3;5;3;4;2;4;3;6;5;6;3;3;3;2;4;3;4;3;7;1;3;5;4;4;6;2;4;4;4;4;2;2;3;4;2;6;4;4;5;5;4;5;4;5;4;6;4;5;3;4;2;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;5;3; GO:0072562;GO:0031982;GO:0016021;GO:0043230;GO:0043234;GO:0044425;GO:0071756;GO:0044421;GO:0071754;GO:0009897;GO:0043227;GO:0043226;GO:0005623;GO:0071757;GO:0016020;GO:0042571;GO:0019814;GO:0031224;GO:0044459;GO:0071753;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0070062;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576; blood microparticle;vesicle;integral component of membrane;extracellular organelle;protein complex;membrane part;pentameric IgM immunoglobulin complex;extracellular region part;IgM immunoglobulin complex, circulating;external side of plasma membrane;membrane-bounded organelle;organelle;cell;hexameric IgM immunoglobulin complex;membrane;immunoglobulin complex, circulating;immunoglobulin complex;intrinsic component of membrane;plasma membrane part;IgM immunoglobulin complex;cell surface;cell part;cell periphery;side of membrane;extracellular exosome;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;4;4;3;3;2;5;2;4;4;3;2;2;5;2;3;4;3;3;5;3;2;3;3;4;3;3;3;2;1;2; GO:0003674;GO:0005488;GO:0003823; molecular_function;binding;antigen binding; 1;2;3; IPR003006;IPR013783;IPR003597;IPR007110; Immunoglobulin/major histocompatibility complex, conserved site;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin-like domain; nucleus P10074 Telomere zinc finger-associated protein OS=Homo sapiens OX=9606 GN=ZBTB48 PE=1 SV=2 - [TZAP_HUMAN] 1.024 0.959 0.716 1.571 0.991 1.337 1.067778936 nan 1.585267407 nan 0.746611053 nan 1.349142281 nan GO:0032774;GO:0044237;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:0034645;GO:0043170;GO:0097659;GO:1901362;GO:0071704;GO:0010467;GO:1901360;GO:0018130;GO:1901576;GO:0009987;GO:0006725;GO:0044260;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0034641;GO:0006351;GO:0019438; RNA biosynthetic process;cellular metabolic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;nucleic acid-templated transcription;organic cyclic compound biosynthetic process;organic substance metabolic process;gene expression;organic cyclic compound metabolic process;heterocycle biosynthetic process;organic substance biosynthetic process;cellular process;cellular aromatic compound metabolic process;cellular macromolecule metabolic process;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound metabolic process;transcription, DNA-templated;aromatic compound biosynthetic process; 6;3;4;5;4;3;5;4;7;5;3;5;4;5;4;2;4;4;3;5;1;2;5;4;5;3;5;4;6;5; GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005575;GO:0031981;GO:0005634;GO:0005654;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;cellular_component;nuclear lumen;nucleus;nucleoplasm;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;3;2;4;1;5;5;5;4;3;2;2;3;3;4;4;3;2; GO:0003674;GO:0001071;GO:0003677;GO:0043167;GO:1901363;GO:0043169;GO:0046872;GO:0003676;GO:0003700;GO:0097159;GO:0005488; molecular_function;nucleic acid binding transcription factor activity;DNA binding;ion binding;heterocyclic compound binding;cation binding;metal ion binding;nucleic acid binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;binding; 1;2;5;3;3;4;5;4;3;3;2; K10519 IPR013087;IPR013083;IPR011333;IPR000210; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;SKP1/BTB/POZ domain;BTB/POZ domain; nucleus Hs4885419 1415.0 R [R] General function prediction only; Q8WVF1 Protein OSCP1 OS=Homo sapiens OX=9606 GN=OSCP1 PE=1 SV=4 - [OSCP1_HUMAN] 0.857 0.642 0.756 1.034 0.825 4.947 1.334890966 nan 1.253333333 nan 1.177570093 nan 5.996363636 nan GO:0033157;GO:0008104;GO:0032388;GO:0060341;GO:0033043;GO:1903651;GO:0032386;GO:0051649;GO:0051128;GO:1903827;GO:0010821;GO:0015031;GO:1903533;GO:0010822;GO:0070585;GO:0051222;GO:0051223;GO:0050789;GO:0071840;GO:0032880;GO:1904951;GO:0070727;GO:0006886;GO:0051641;GO:0016043;GO:0065007;GO:1903829;GO:0032879;GO:0051049;GO:0048518;GO:1903749;GO:0007005;GO:0070201;GO:0034613;GO:1903649;GO:0051050;GO:0072594;GO:0006626;GO:0006810;GO:0090316;GO:0006605;GO:0045184;GO:1903747;GO:1903955;GO:0008150;GO:0072655;GO:0006839;GO:0050794;GO:0051179;GO:1902578;GO:0016482;GO:0006996;GO:0051234;GO:0044699;GO:0033036;GO:0071702;GO:0046907;GO:0010638;GO:0044765;GO:1903214;GO:0033365;GO:1902582;GO:0009987;GO:1902580;GO:0051130;GO:0048522; regulation of intracellular protein transport;protein localization;positive regulation of intracellular transport;regulation of cellular localization;regulation of organelle organization;positive regulation of cytoplasmic transport;regulation of intracellular transport;establishment of localization in cell;regulation of cellular component organization;regulation of cellular protein localization;regulation of mitochondrion organization;protein transport;regulation of protein targeting;positive regulation of mitochondrion organization;protein localization to mitochondrion;positive regulation of protein transport;regulation of protein transport;regulation of biological process;cellular component organization or biogenesis;regulation of protein localization;positive regulation of establishment of protein localization;cellular macromolecule localization;intracellular protein transport;cellular localization;cellular component organization;biological regulation;positive regulation of cellular protein localization;regulation of localization;regulation of transport;positive regulation of biological process;positive regulation of establishment of protein localization to mitochondrion;mitochondrion organization;regulation of establishment of protein localization;cellular protein localization;regulation of cytoplasmic transport;positive regulation of transport;establishment of protein localization to organelle;protein targeting to mitochondrion;transport;positive regulation of intracellular protein transport;protein targeting;establishment of protein localization;regulation of establishment of protein localization to mitochondrion;positive regulation of protein targeting to mitochondrion;biological_process;establishment of protein localization to mitochondrion;mitochondrial transport;regulation of cellular process;localization;single-organism localization;cytosolic transport;organelle organization;establishment of localization;single-organism process;macromolecule localization;organic substance transport;intracellular transport;positive regulation of organelle organization;single-organism transport;regulation of protein targeting to mitochondrion;protein localization to organelle;single-organism intracellular transport;cellular process;single-organism cellular localization;positive regulation of cellular component organization;positive regulation of cellular process; 6;4;4;4;5;5;5;4;4;5;6;5;7;6;7;4;5;2;2;4;3;4;6;3;3;2;3;3;4;2;4;5;5;5;6;3;5;5;4;4;6;4;6;5;1;6;6;3;2;3;6;4;3;2;3;5;5;5;4;6;6;5;2;4;4;3; GO:0098590;GO:0009925;GO:0016323;GO:0071944;GO:0098589;GO:0016020;GO:0045178;GO:0044425;GO:0044464;GO:0005886;GO:0044459;GO:0005623;GO:0005575;GO:0098805; plasma membrane region;basal plasma membrane;basolateral plasma membrane;cell periphery;membrane region;membrane;basal part of cell;membrane part;cell part;plasma membrane;plasma membrane part;cell;cellular_component;whole membrane; 4;4;4;3;3;2;3;2;2;3;3;2;1;3; IPR019332; Organic solute carrier protein 1; cytosol Hs21450798 765.0 S [S] Function unknown; O75886 Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1 - [STAM2_HUMAN] 1.261 0.883 1.015 1.084 0.86 1.266 1.42808607 nan 1.260465116 nan 1.149490374 nan 1.472093023 nan GO:0008104;GO:0048585;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0051716;GO:0070727;GO:0009966;GO:0010256;GO:0065007;GO:0033036;GO:0016197;GO:0045184;GO:0007173;GO:0044700;GO:0038127;GO:0022607;GO:1901184;GO:1901185;GO:0006886;GO:0016043;GO:0006810;GO:0050794;GO:0008150;GO:0051234;GO:0009968;GO:0046907;GO:0050896;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0044699;GO:0009987;GO:0048519;GO:0007032;GO:0007033;GO:0007034;GO:0042059;GO:0042058;GO:0050789;GO:0071702;GO:0036258;GO:0036257;GO:0006914;GO:0034613;GO:0044765;GO:0044763;GO:0051649;GO:0007154;GO:0070925;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044085;GO:0015031;GO:1902582;GO:0048523; protein localization;negative regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;cellular macromolecule localization;regulation of signal transduction;endomembrane system organization;biological regulation;macromolecule localization;endosomal transport;establishment of protein localization;epidermal growth factor receptor signaling pathway;single organism signaling;ERBB signaling pathway;cellular component assembly;regulation of ERBB signaling pathway;negative regulation of ERBB signaling pathway;intracellular protein transport;cellular component organization;transport;regulation of cellular process;biological_process;establishment of localization;negative regulation of signal transduction;intracellular transport;response to stimulus;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;single-organism process;cellular process;negative regulation of biological process;endosome organization;vacuole organization;vacuolar transport;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;regulation of biological process;organic substance transport;multivesicular body assembly;multivesicular body organization;autophagy;cellular protein localization;single-organism transport;single-organism cellular process;establishment of localization in cell;cell communication;organelle assembly;localization;single-organism localization;cellular localization;organelle organization;cellular component biogenesis;protein transport;single-organism intracellular transport;negative regulation of cellular process; 4;3;3;4;4;5;6;7;2;3;4;4;4;2;3;7;4;9;3;8;4;5;5;6;3;4;3;1;3;4;5;2;3;2;4;3;4;2;2;2;5;5;6;6;6;2;5;6;6;3;5;4;3;4;4;5;2;3;3;4;3;5;5;3; GO:0031974;GO:0031981;GO:0016020;GO:0005774;GO:0031901;GO:0098588;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044437;GO:0012505;GO:0036452;GO:0044446;GO:0005773;GO:0044444;GO:0044440;GO:0010008;GO:0005737;GO:0031090;GO:0005634;GO:0033565;GO:0044464;GO:0005623;GO:0005622;GO:0098805;GO:0032991;GO:0005575;GO:0070013;GO:0005768;GO:0005769; membrane-enclosed lumen;nuclear lumen;membrane;vacuolar membrane;early endosome membrane;bounding membrane of organelle;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;vacuolar part;endomembrane system;ESCRT complex;intracellular organelle part;vacuole;cytoplasmic part;endosomal part;endosome membrane;cytoplasm;organelle membrane;nucleus;ESCRT-0 complex;cell part;cell;intracellular;whole membrane;macromolecular complex;cellular_component;intracellular organelle lumen;endosome;early endosome; 2;5;2;4;6;4;3;4;3;5;4;3;2;3;3;2;5;4;3;4;3;5;4;5;5;4;3;5;5;2;2;3;3;2;1;4;4;5; K04705 map04144;map04630; Endocytosis;Jak-STAT signaling pathway; IPR001452;IPR035675;IPR002014;IPR003903;IPR008942; SH3 domain;STAM2, SH3 domain;VHS domain;Ubiquitin interacting motif;ENTH/VHS; nucleus Hs21265031 1088.0 T [T] Signal transduction mechanisms; Q8N7X0 Androglobin OS=Homo sapiens OX=9606 GN=ADGB PE=2 SV=3 - [ADGB_HUMAN] 0.888 1.004 0.982 0.889 1.33 1.318 0.884462151 nan 0.668421053 nan 0.978087649 nan 0.990977444 nan GO:0071704;GO:0006508;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0043170; organic substance metabolic process;proteolysis;biological_process;metabolic process;primary metabolic process;protein metabolic process;macromolecule metabolic process; 3;5;1;2;3;4;4; GO:0005622;GO:0044464;GO:0005623;GO:0005575; intracellular;cell part;cell;cellular_component; 3;2;2;1; GO:0004175;GO:0003674;GO:0005488;GO:0008233;GO:1901363;GO:0008234;GO:0070011;GO:0016787;GO:0020037;GO:0003824;GO:0019825;GO:0046906;GO:0097159;GO:0004197;GO:0004198; endopeptidase activity;molecular_function;binding;peptidase activity;heterocyclic compound binding;cysteine-type peptidase activity;peptidase activity, acting on L-amino acid peptides;hydrolase activity;heme binding;catalytic activity;oxygen binding;tetrapyrrole binding;organic cyclic compound binding;cysteine-type endopeptidase activity;calcium-dependent cysteine-type endopeptidase activity; 6;1;2;4;3;6;5;3;5;2;3;4;3;7;8; IPR001300;IPR000048; Peptidase C2, calpain, catalytic domain;IQ motif, EF-hand binding site; nucleus B9A064 Immunoglobulin lambda-like polypeptide 5 OS=Homo sapiens OX=9606 GN=IGLL5 PE=2 SV=2 - [IGLL5_HUMAN] 1.066 1.079 0.9 0.957 1.155 0.77 0.987951807 0.431659711 0.828571429 3.40E-13 0.834105653 0.000209042 0.666666667 0.724665228 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0051716;GO:0043207;GO:0009617;GO:0048518;GO:0065007;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0050789;GO:0002764;GO:0002768;GO:0016043;GO:0002684;GO:0002682;GO:0006810;GO:0044710;GO:0050794;GO:0006952;GO:0006950;GO:0051249;GO:0008150;GO:0006955;GO:0006958;GO:0051234;GO:0002757;GO:0006897;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0006956;GO:0008152;GO:0023052;GO:0044699;GO:0016064;GO:0008037;GO:0009987;GO:0050871;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0042742;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0006959;GO:0072376;GO:0002443;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;cellular response to stimulus;response to external biotic stimulus;response to bacterium;positive regulation of biological process;biological regulation;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;immune response-regulating cell surface receptor signaling pathway;cellular component organization;positive regulation of immune system process;regulation of immune system process;transport;single-organism metabolic process;regulation of cellular process;defense response;response to stress;regulation of lymphocyte activation;biological_process;immune response;complement activation, classical pathway;establishment of localization;immune response-activating signal transduction;endocytosis;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;metabolic process;signaling;single-organism process;immunoglobulin mediated immune response;cell recognition;cellular process;positive regulation of B cell activation;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;defense response to bacterium;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;humoral immune response;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;4;2;2;6;4;3;3;2;3;5;5;3;4;2;3;2;5;6;3;3;3;4;3;3;4;3;5;1;3;5;3;4;6;2;4;4;4;4;2;2;2;7;4;2;6;4;4;5;5;4;5;4;5;4;6;4;5;4;3;4;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;3; GO:0031982;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0043227;GO:0016020;GO:0005623;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;membrane-bounded organelle;membrane;cell;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;3;3;2;2;4;3;2;2;3;4;3;3;2;3;3;3;2;3;3;4;2;1;2;3; GO:0003674;GO:0005488;GO:0034987;GO:0003823;GO:0005515;GO:0005102; molecular_function;binding;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding; 1;2;5;3;3;4; IPR003006;IPR013783;IPR003597;IPR007110; Immunoglobulin/major histocompatibility complex, conserved site;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin-like domain; nucleus O75882 Attractin OS=Homo sapiens OX=9606 GN=ATRN PE=1 SV=2 - [ATRN_HUMAN] 0.923 0.962 1.182 0.974 0.998 1.031 0.959459459 0.311146425 0.975951904 0.276291606 1.228690229 1.67E-08 1.033066132 0.093051387 GO:0048638;GO:0006954;GO:0048589;GO:0022037;GO:0050789;GO:0035264;GO:0007272;GO:0007275;GO:0044699;GO:0007420;GO:0021549;GO:0042552;GO:0040008;GO:0048513;GO:0065007;GO:0007417;GO:0032502;GO:0032501;GO:0060322;GO:0050793;GO:0009987;GO:0006952;GO:0044767;GO:0006950;GO:0044763;GO:0008366;GO:0051239;GO:0048731;GO:0040007;GO:0006979;GO:0040014;GO:0043473;GO:0044707;GO:0007399;GO:0050896;GO:0048856;GO:0030902;GO:0008150; regulation of developmental growth;inflammatory response;developmental growth;metencephalon development;regulation of biological process;multicellular organism growth;ensheathment of neurons;multicellular organism development;single-organism process;brain development;cerebellum development;myelination;regulation of growth;animal organ development;biological regulation;central nervous system development;developmental process;multicellular organismal process;head development;regulation of developmental process;cellular process;defense response;single-organism developmental process;response to stress;single-organism cellular process;axon ensheathment;regulation of multicellular organismal process;system development;growth;response to oxidative stress;regulation of multicellular organism growth;pigmentation;single-multicellular organism process;nervous system development;response to stimulus;anatomical structure development;hindbrain development;biological_process; 4;5;3;4;2;4;4;4;2;4;4;6;3;4;2;5;2;2;4;3;2;4;3;3;3;5;3;4;2;4;4;3;3;5;2;3;4;1; GO:0016021;GO:0005886;GO:0071944;GO:0005887;GO:0043227;GO:0005737;GO:0070062;GO:0005615;GO:0031226;GO:0016020;GO:0043226;GO:0031224;GO:0044425;GO:0044459;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421; integral component of membrane;plasma membrane;cell periphery;integral component of plasma membrane;membrane-bounded organelle;cytoplasm;extracellular exosome;extracellular space;intrinsic component of plasma membrane;membrane;organelle;intrinsic component of membrane;membrane part;plasma membrane part;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part; 4;3;3;4;3;4;4;3;4;2;2;3;2;3;3;4;3;2;2;3;1;2;3;2; GO:0030246;GO:0003674;GO:0005488;GO:0060089;GO:0004872; carbohydrate binding;molecular_function;binding;molecular transducer activity;receptor activity; 3;1;2;2;3; IPR000742;IPR016186;IPR002165;IPR015915;IPR000859;IPR016201;IPR011043;IPR015916;IPR001304;IPR016187;IPR013032;IPR006652;IPR002049;IPR034011; EGF-like domain;C-type lectin-like/link domain;Plexin repeat;Kelch-type beta propeller;CUB domain;PSI domain;Galactose oxidase/kelch, beta-propeller;Galactose oxidase, beta-propeller;C-type lectin-like;C-type lectin fold;EGF-like, conserved site;Kelch repeat type 1;Laminin EGF domain;Attractin-like, C-type lectin-like domain; plasma membrane Hs21450861 2989.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; Q9UGJ1 Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1 - [GCP4_HUMAN] 1.081 1.273 1.416 0.994 1.012 0.731 0.849175177 0.61011893 0.982213439 0.677034611 1.112333071 0.365001837 0.722332016 0.326663166 GO:0031110;GO:0031112;GO:0031113;GO:0031116;GO:0000086;GO:0051415;GO:0010968;GO:0071840;GO:0051418;GO:0000003;GO:0051495;GO:0033043;GO:0051493;GO:0048518;GO:0051298;GO:0031109;GO:0044702;GO:0010638;GO:0050789;GO:0070507;GO:0022607;GO:0000226;GO:0007067;GO:0090063;GO:0016043;GO:0065003;GO:0065007;GO:0007049;GO:0051130;GO:0050794;GO:0007051;GO:0007052;GO:0008150;GO:0043254;GO:0070271;GO:0051128;GO:0032886;GO:0044699;GO:0007126;GO:0051321;GO:0000280;GO:0046785;GO:0032273;GO:1902850;GO:0032271;GO:0031023;GO:0009987;GO:0031334;GO:0051258;GO:0051225;GO:0044839;GO:0043933;GO:1903047;GO:1903046;GO:0044770;GO:0044772;GO:0090307;GO:0022402;GO:0034622;GO:0007020;GO:0071822;GO:0051297;GO:0000278;GO:0006461;GO:0031122;GO:0022414;GO:0044763;GO:0070925;GO:0043623;GO:0006996;GO:0007017;GO:0007010;GO:0044087;GO:1902589;GO:0044085;GO:0007098;GO:0048285;GO:0044089;GO:0048522; regulation of microtubule polymerization or depolymerization;positive regulation of microtubule polymerization or depolymerization;regulation of microtubule polymerization;positive regulation of microtubule polymerization;G2/M transition of mitotic cell cycle;interphase microtubule nucleation by interphase microtubule organizing center;regulation of microtubule nucleation;cellular component organization or biogenesis;microtubule nucleation by microtubule organizing center;reproduction;positive regulation of cytoskeleton organization;regulation of organelle organization;regulation of cytoskeleton organization;positive regulation of biological process;centrosome duplication;microtubule polymerization or depolymerization;single organism reproductive process;positive regulation of organelle organization;regulation of biological process;regulation of microtubule cytoskeleton organization;cellular component assembly;microtubule cytoskeleton organization;mitotic nuclear division;positive regulation of microtubule nucleation;cellular component organization;macromolecular complex assembly;biological regulation;cell cycle;positive regulation of cellular component organization;regulation of cellular process;spindle organization;mitotic spindle organization;biological_process;regulation of protein complex assembly;protein complex biogenesis;regulation of cellular component organization;regulation of microtubule-based process;single-organism process;meiotic nuclear division;meiotic cell cycle;nuclear division;microtubule polymerization;positive regulation of protein polymerization;microtubule cytoskeleton organization involved in mitosis;regulation of protein polymerization;microtubule organizing center organization;cellular process;positive regulation of protein complex assembly;protein polymerization;spindle assembly;cell cycle G2/M phase transition;macromolecular complex subunit organization;mitotic cell cycle process;meiotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;mitotic spindle assembly;cell cycle process;cellular macromolecular complex assembly;microtubule nucleation;protein complex subunit organization;centrosome organization;mitotic cell cycle;protein complex assembly;cytoplasmic microtubule organization;reproductive process;single-organism cellular process;organelle assembly;cellular protein complex assembly;organelle organization;microtubule-based process;cytoskeleton organization;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;centrosome cycle;organelle fission;positive regulation of cellular component biogenesis;positive regulation of cellular process; 6;7;6;6;6;5;7;2;7;2;6;5;6;2;5;6;3;5;2;5;4;5;5;7;3;5;2;4;4;3;5;6;1;4;4;4;4;2;4;3;6;7;5;6;5;5;2;4;7;6;6;4;5;4;5;6;6;4;6;6;5;6;5;5;6;2;3;5;6;4;4;5;3;4;3;5;5;3;3; GO:0099512;GO:0099513;GO:0008274;GO:0005815;GO:0005773;GO:0000923;GO:0000922;GO:0032153;GO:0032155;GO:0043234;GO:0043231;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0012505;GO:0044446;GO:0044444;GO:0016020;GO:0055037;GO:0005874;GO:0005737;GO:0044450;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0005819;GO:0005813;GO:0005816;GO:0015630;GO:0000930;GO:0000931;GO:0005575;GO:0005768; supramolecular fiber;polymeric cytoskeletal fiber;gamma-tubulin ring complex;microtubule organizing center;vacuole;equatorial microtubule organizing center;spindle pole;cell division site;cell division site part;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;endomembrane system;intracellular organelle part;cytoplasmic part;membrane;recycling endosome;microtubule;cytoplasm;microtubule organizing center part;macromolecular complex;cell part;cell;intracellular;spindle;centrosome;spindle pole body;microtubule cytoskeleton;gamma-tubulin complex;gamma-tubulin large complex;cellular_component;endosome; 2;3;6;5;5;4;5;3;3;3;4;4;5;3;2;3;3;3;2;5;4;3;3;4;2;5;4;4;5;2;2;2;3;5;5;6;6;4;5;1;4; GO:0005488;GO:0008092;GO:0043015;GO:0005515;GO:0003674;GO:0005200;GO:0005198;GO:0015631; binding;cytoskeletal protein binding;gamma-tubulin binding;protein binding;molecular_function;structural constituent of cytoskeleton;structural molecule activity;tubulin binding; 2;4;6;3;1;3;2;5; K16571 IPR007259; Gamma-tubulin complex component protein; extracellular Hs7656841 1370.0 Z [Z] Cytoskeleton; Q08830 Fibrinogen-like protein 1 OS=Homo sapiens OX=9606 GN=FGL1 PE=1 SV=3 - [FGL1_HUMAN] 0.914 0.978 1.279 0.871 1.102 0.899 0.934560327 nan 0.790381125 nan 1.307770961 nan 0.815789474 nan GO:0043234;GO:0032991;GO:0005615;GO:0031982;GO:0043226;GO:0005575;GO:0005577;GO:0005576;GO:0043230;GO:1903561;GO:0043227;GO:0044421;GO:0070062; protein complex;macromolecular complex;extracellular space;vesicle;organelle;cellular_component;fibrinogen complex;extracellular region;extracellular organelle;extracellular vesicle;membrane-bounded organelle;extracellular region part;extracellular exosome; 3;2;3;4;2;1;3;2;3;3;3;2;4; IPR002181;IPR014716;IPR014715;IPR020837; Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, conserved site; extracellular Hs4758372 650.0 R [R] General function prediction only; A7E2Y1 Myosin-7B OS=Homo sapiens OX=9606 GN=MYH7B PE=1 SV=4 - [MYH7B_HUMAN] 1.111 1.478 0.863 0.828 0.994 0.731 0.751691475 nan 0.832997988 nan 0.583897158 nan 0.735412475 nan GO:0015629;GO:0043229;GO:0043228;GO:0044430;GO:0043226;GO:0005856;GO:0005575;GO:0032982;GO:0016020;GO:0016459;GO:0043234;GO:0032991;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0044424;GO:0044422; actin cytoskeleton;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;organelle;cytoskeleton;cellular_component;myosin filament;membrane;myosin complex;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;intracellular part;organelle part; 6;3;3;4;2;5;1;5;2;4;3;2;4;2;2;3;3;3;2; GO:0035639;GO:1901363;GO:0003674;GO:0000166;GO:1901265;GO:0001882;GO:0043167;GO:0001883;GO:0032549;GO:0017076;GO:0003774;GO:0005524;GO:0016787;GO:0017111;GO:0036094;GO:0003824;GO:0032555;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032550;GO:0032559;GO:0032553;GO:0043168;GO:0005488; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;nucleotide binding;nucleoside phosphate binding;nucleoside binding;ion binding;purine nucleoside binding;ribonucleoside binding;purine nucleotide binding;motor activity;ATP binding;hydrolase activity;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;purine ribonucleoside binding;adenyl ribonucleotide binding;ribonucleotide binding;anion binding;binding; 5;3;1;4;4;4;3;5;5;5;8;6;3;7;3;2;5;5;6;3;3;4;6;6;6;4;4;2; K10352 map04530; Tight junction; IPR000048;IPR004009;IPR027417;IPR001609;IPR002928; IQ motif, EF-hand binding site;Myosin, N-terminal, SH3-like;P-loop containing nucleoside triphosphate hydrolase;Myosin head, motor domain;Myosin tail; mitochondria Hs4557773 2729.0 Z [Z] Cytoskeleton; Q9P0U4 CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2 - [CXXC1_HUMAN] 0.705 1.703 0.266 2.493 0.519 0.861 0.413975338 0.032325947 4.803468208 0.013576369 0.15619495 0.009442173 1.658959538 0.092828162 GO:0006479;GO:0080090;GO:0019222;GO:0007165;GO:0051568;GO:1901362;GO:1901360;GO:0051716;GO:0006986;GO:0010604;GO:0010467;GO:0018193;GO:0048518;GO:0016571;GO:0016570;GO:0060255;GO:2001141;GO:0010033;GO:0046483;GO:0044700;GO:0030968;GO:0019538;GO:0018205;GO:0033554;GO:0019438;GO:0070887;GO:0018022;GO:0051254;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0032259;GO:0018130;GO:0009889;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0043412;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0043414;GO:0016569;GO:0032774;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0042221;GO:0044699;GO:0009893;GO:0006139;GO:0009891;GO:0034968;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051276;GO:0008213;GO:0051252;GO:0043170;GO:1902680;GO:0035967;GO:0035966;GO:0034976;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0034620;GO:0010628;GO:0006325;GO:2000112;GO:0050789;GO:0071704;GO:0071310;GO:0010468;GO:0045935;GO:0044267;GO:0019219;GO:0006464;GO:0036498;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0007154;GO:0016568;GO:0006996;GO:0044238;GO:0044237;GO:1902589;GO:0048522; protein methylation;regulation of primary metabolic process;regulation of metabolic process;signal transduction;histone H3-K4 methylation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;response to unfolded protein;positive regulation of macromolecule metabolic process;gene expression;peptidyl-amino acid modification;positive regulation of biological process;histone methylation;histone modification;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;single organism signaling;endoplasmic reticulum unfolded protein response;protein metabolic process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;cellular response to chemical stimulus;peptidyl-lysine methylation;positive regulation of RNA metabolic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;methylation;heterocycle biosynthetic process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;macromolecule modification;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;macromolecule methylation;covalent chromatin modification;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;response to chemical;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;positive regulation of biosynthetic process;histone lysine methylation;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;chromosome organization;protein alkylation;regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;cellular response to topologically incorrect protein;response to topologically incorrect protein;response to endoplasmic reticulum stress;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular response to unfolded protein;positive regulation of gene expression;chromatin organization;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;cellular response to organic substance;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;IRE1-mediated unfolded protein response;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;chromatin modification;organelle organization;primary metabolic process;cellular metabolic process;single-organism organelle organization;positive regulation of cellular process; 5;4;3;4;7;5;4;3;5;4;5;7;2;5;4;4;6;4;4;3;5;4;8;4;5;4;6;5;3;7;4;4;3;2;2;3;5;4;3;3;3;5;1;2;5;5;5;2;5;6;5;5;6;4;7;6;4;4;2;5;3;2;3;4;4;6;7;2;4;7;6;5;7;5;4;6;5;4;5;5;4;5;4;4;5;6;5;5;6;2;3;5;5;5;5;5;6;6;3;5;3;4;4;4;6;4;3;3;4;3; GO:0031974;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0016363;GO:0043231;GO:0043233;GO:0048188;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0005654;GO:0034399;GO:0035097;GO:0044446;GO:0005737;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0034708;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;catalytic complex;transferase complex;protein complex;nuclear matrix;intracellular membrane-bounded organelle;organelle lumen;Set1C/COMPASS complex;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;nucleoplasm;nuclear periphery;histone methyltransferase complex;intracellular organelle part;cytoplasm;nucleus;nucleoplasm part;cell part;cell;methyltransferase complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;5;3;5;4;3;6;4;3;2;3;3;3;2;7;6;5;5;5;3;4;5;5;2;2;4;2;1;4; GO:0043169;GO:1901363;GO:0046872;GO:0044212;GO:0001067;GO:0008270;GO:0001159;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000987;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:1990837;GO:0043167;GO:0003690;GO:0045322;GO:0046914; cation binding;heterocyclic compound binding;metal ion binding;transcription regulatory region DNA binding;regulatory region nucleic acid binding;zinc ion binding;core promoter proximal region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter proximal region sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;sequence-specific double-stranded DNA binding;ion binding;double-stranded DNA binding;unmethylated CpG binding;transition metal ion binding; 4;3;5;7;5;7;8;1;2;4;5;9;6;3;8;6;7;3;6;7;6; K14960 IPR022056;IPR019787;IPR019786;IPR011011;IPR013083;IPR001965;IPR002857; CpG binding protein, C-terminal;Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;Zinc finger, PHD-type;Zinc finger, CXXC-type; nucleus Hs7656975 1347.0 R [R] General function prediction only; Q6EMK4 Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 SV=1 - [VASN_HUMAN] 0.852 0.878 1.455 0.89 0.821 1.346 0.970387244 0.696252925 1.084043849 0.992023495 1.657175399 0.162253751 1.639464068 0.027907596 GO:2000736;GO:2000737;GO:0048585;GO:0048468;GO:0007165;GO:0007166;GO:0007167;GO:0032989;GO:0071840;GO:0051716;GO:0048863;GO:0048864;GO:0009968;GO:0009966;GO:0048869;GO:0070848;GO:0030512;GO:0048513;GO:0010721;GO:0048519;GO:0048762;GO:0048583;GO:0010033;GO:0007179;GO:0007178;GO:0044700;GO:0044707;GO:0007154;GO:0033554;GO:0010648;GO:0022604;GO:0022603;GO:0023051;GO:0051775;GO:0050789;GO:0001666;GO:0000902;GO:0090101;GO:0010646;GO:0016043;GO:0071453;GO:0065007;GO:0071456;GO:1903844;GO:0009719;GO:0050793;GO:0017015;GO:0009888;GO:0050794;GO:0006950;GO:0014031;GO:0008150;GO:0051239;GO:0010719;GO:0010717;GO:0036293;GO:0050896;GO:0036294;GO:0030154;GO:0051129;GO:0051128;GO:0023057;GO:0023052;GO:0060284;GO:0070887;GO:0060485;GO:0009653;GO:0044699;GO:0090287;GO:0051241;GO:0090288;GO:0010769;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0051093;GO:0071363;GO:0071560;GO:0010771;GO:0048731;GO:0071495;GO:0007275;GO:1903845;GO:0071310;GO:0071559;GO:0071461;GO:0090092;GO:0044767;GO:0000904;GO:0044763;GO:0042221;GO:0070482;GO:0009628;GO:0048856;GO:0001837;GO:2000026;GO:0048523; regulation of stem cell differentiation;negative regulation of stem cell differentiation;negative regulation of response to stimulus;cell development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;stem cell differentiation;stem cell development;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;response to growth factor;negative regulation of transforming growth factor beta receptor signaling pathway;animal organ development;negative regulation of cell development;negative regulation of biological process;mesenchymal cell differentiation;regulation of response to stimulus;response to organic substance;transforming growth factor beta receptor signaling pathway;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;single-multicellular organism process;cell communication;cellular response to stress;negative regulation of cell communication;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;regulation of signaling;response to redox state;regulation of biological process;response to hypoxia;cell morphogenesis;negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of cell communication;cellular component organization;cellular response to oxygen levels;biological regulation;cellular response to hypoxia;regulation of cellular response to transforming growth factor beta stimulus;response to endogenous stimulus;regulation of developmental process;regulation of transforming growth factor beta receptor signaling pathway;tissue development;regulation of cellular process;response to stress;mesenchymal cell development;biological_process;regulation of multicellular organismal process;negative regulation of epithelial to mesenchymal transition;regulation of epithelial to mesenchymal transition;response to decreased oxygen levels;response to stimulus;cellular response to decreased oxygen levels;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;negative regulation of signaling;signaling;regulation of cell development;cellular response to chemical stimulus;mesenchyme development;anatomical structure morphogenesis;single-organism process;regulation of cellular response to growth factor stimulus;negative regulation of multicellular organismal process;negative regulation of cellular response to growth factor stimulus;regulation of cell morphogenesis involved in differentiation;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of developmental process;cellular response to growth factor stimulus;cellular response to transforming growth factor beta stimulus;negative regulation of cell morphogenesis involved in differentiation;system development;cellular response to endogenous stimulus;multicellular organism development;negative regulation of cellular response to transforming growth factor beta stimulus;cellular response to organic substance;response to transforming growth factor beta;cellular response to redox state;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;single-organism developmental process;cell morphogenesis involved in differentiation;single-organism cellular process;response to chemical;response to oxygen levels;response to abiotic stimulus;anatomical structure development;epithelial to mesenchymal transition;regulation of multicellular organismal development;negative regulation of cellular process; 5;5;3;4;4;5;6;4;2;3;6;5;4;4;4;5;6;4;5;2;6;3;4;6;7;3;3;4;4;4;5;4;3;3;2;4;5;5;4;3;5;2;5;5;3;3;6;4;3;3;6;1;3;4;5;5;2;6;5;4;4;3;2;5;4;5;3;2;4;3;4;6;2;2;2;4;4;3;6;5;5;4;4;4;5;5;4;4;5;3;5;3;3;4;3;3;6;4;3; GO:0031982;GO:0016021;GO:0016020;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044437;GO:0031224;GO:0044446;GO:0005773;GO:0044444;GO:0098852;GO:0000323;GO:0005737;GO:0031090;GO:0005739;GO:0005615;GO:0009986;GO:0005774;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005764;GO:0070062;GO:0098805;GO:0043226;GO:0005886;GO:1903561;GO:0005575;GO:0005765;GO:0005576; vesicle;integral component of membrane;membrane;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;vacuolar part;intrinsic component of membrane;intracellular organelle part;vacuole;cytoplasmic part;lytic vacuole membrane;lytic vacuole;cytoplasm;organelle membrane;mitochondrion;extracellular space;cell surface;vacuolar membrane;cell part;cell;intracellular;cell periphery;lysosome;extracellular exosome;whole membrane;organelle;plasma membrane;extracellular vesicle;cellular_component;lysosomal membrane;extracellular region; 4;4;2;4;3;4;3;2;2;2;3;3;4;3;3;5;4;5;6;4;3;5;3;3;4;2;2;3;3;7;4;3;2;3;3;1;6;2; GO:0019955;GO:0003674;GO:0005488;GO:0019838;GO:0050431;GO:0005515; cytokine binding;molecular_function;binding;growth factor binding;transforming growth factor beta binding;protein binding; 4;1;2;4;5;3; IPR013783;IPR001611;IPR003591;IPR003961;IPR032675;IPR000742;IPR013032;IPR000483;IPR000372; Immunoglobulin-like fold;Leucine-rich repeat;Leucine-rich repeat, typical subtype;Fibronectin type III;Leucine-rich repeat domain, L domain-like;EGF-like domain;EGF-like, conserved site;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat N-terminal domain; extracellular Hs15029530 143.0 R [R] General function prediction only; O60676 Cystatin-8 OS=Homo sapiens OX=9606 GN=CST8 PE=1 SV=1 - [CST8_HUMAN] 1.41 1.076 0.586 1.305 0.964 0.887 1.310408922 nan 1.35373444 nan 0.544609665 nan 0.920124481 nan GO:0009892;GO:0019222;GO:0031324;GO:0031323;GO:0043170;GO:0044237;GO:0043086;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0051346;GO:0044260;GO:0051246;GO:0050789;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0009987;GO:0052547;GO:0052548;GO:0050794;GO:0008150;GO:0006508;GO:0010951;GO:0008152;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0050790;GO:0060255;GO:0019538;GO:0030162;GO:0045861;GO:0048523; negative regulation of metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;macromolecule metabolic process;cellular metabolic process;negative regulation of catalytic activity;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of protein metabolic process;regulation of biological process;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;cellular process;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular process;biological_process;proteolysis;negative regulation of endopeptidase activity;metabolic process;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of catalytic activity;regulation of macromolecule metabolic process;protein metabolic process;regulation of proteolysis;negative regulation of proteolysis;negative regulation of cellular process; 3;3;4;4;4;3;5;4;5;5;4;6;4;5;2;3;7;2;4;2;3;2;6;7;3;1;5;8;2;5;3;5;5;4;4;4;6;6;3; GO:0005737;GO:0009986;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424; cytoplasm;cell surface;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part; 4;3;2;2;3;1;2;3; GO:0004866;GO:0061135;GO:0003674;GO:0004857;GO:0098772;GO:0030234;GO:0061134;GO:0030414;GO:0004869; endopeptidase inhibitor activity;endopeptidase regulator activity;molecular_function;enzyme inhibitor activity;molecular function regulator;enzyme regulator activity;peptidase regulator activity;peptidase inhibitor activity;cysteine-type endopeptidase inhibitor activity; 6;5;1;4;2;3;4;5;7; K13904 IPR000010;IPR027214; Cystatin domain;Cystatin; extracellular Q8N456 Leucine-rich repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=LRRC18 PE=2 SV=2 - [LRC18_HUMAN] 0.938 1.178 1.175 0.847 1.098 0.656 0.796264856 nan 0.77140255 nan 0.997453311 nan 0.597449909 nan GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; IPR003591;IPR001611;IPR032675; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Leucine-rich repeat domain, L domain-like; cytosol Hs22046109 81.3 R [R] General function prediction only; Q9P1V8 Sterile alpha motif domain-containing protein 15 OS=Homo sapiens OX=9606 GN=SAMD15 PE=2 SV=1 - [SAM15_HUMAN] 0.798 1.119 1.035 1.092 1.143 1.129 0.713136729 nan 0.955380577 nan 0.924932976 nan 0.987751531 nan IPR013761;IPR001660; Sterile alpha motif/pointed domain;Sterile alpha motif domain; nucleus Q9BUI4 DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1 - [RPC3_HUMAN] 0.997 0.914 1 1.266 1.197 0.532 1.090809628 nan 1.05764411 nan 1.094091904 nan 0.444444444 nan GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0031349;GO:1901362;GO:0044707;GO:1901360;GO:0009615;GO:0032728;GO:0048518;GO:0006386;GO:0006385;GO:0046483;GO:0006383;GO:0060255;GO:2001141;GO:0051707;GO:0051704;GO:0009607;GO:0009605;GO:0002376;GO:0019438;GO:0032648;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0002684;GO:0002682;GO:0031347;GO:0018130;GO:0009889;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:0016070;GO:0044271;GO:0051607;GO:0050896;GO:0032481;GO:0006355;GO:0051239;GO:0006351;GO:0006353;GO:0043207;GO:0051240;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0098542;GO:0050776;GO:0051252;GO:0050778;GO:0001816;GO:0001817;GO:0032479;GO:0080134;GO:0001819;GO:0032608;GO:0031326;GO:0031323;GO:0032606;GO:0090304;GO:0006354;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045089;GO:0045088;GO:0019219;GO:0045087;GO:0009058;GO:0009059;GO:0051171;GO:0044238;GO:0065007;GO:0044237;GO:0006359;GO:0002252; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;organic cyclic compound biosynthetic process;single-multicellular organism process;organic cyclic compound metabolic process;response to virus;positive regulation of interferon-beta production;positive regulation of biological process;termination of RNA polymerase III transcription;transcription elongation from RNA polymerase III promoter;heterocycle metabolic process;transcription from RNA polymerase III promoter;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;response to other organism;multi-organism process;response to biotic stimulus;response to external stimulus;immune system process;aromatic compound biosynthetic process;regulation of interferon-beta production;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;positive regulation of immune system process;regulation of immune system process;regulation of defense response;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;defense response to virus;response to stimulus;positive regulation of type I interferon production;regulation of transcription, DNA-templated;regulation of multicellular organismal process;transcription, DNA-templated;DNA-templated transcription, termination;response to external biotic stimulus;positive regulation of multicellular organismal process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;defense response to other organism;regulation of immune response;regulation of RNA metabolic process;positive regulation of immune response;cytokine production;regulation of cytokine production;regulation of type I interferon production;regulation of response to stress;positive regulation of cytokine production;interferon-beta production;regulation of cellular biosynthetic process;regulation of cellular metabolic process;type I interferon production;nucleic acid metabolic process;DNA-templated transcription, elongation;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;positive regulation of innate immune response;regulation of innate immune response;regulation of nucleobase-containing compound metabolic process;innate immune response;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;primary metabolic process;biological regulation;cellular metabolic process;regulation of transcription from RNA polymerase III promoter;immune effector process; 4;3;3;3;4;5;3;4;4;6;2;8;8;4;7;4;6;3;2;3;3;2;5;6;3;4;2;7;4;4;3;3;5;5;4;3;4;3;1;2;3;5;5;5;4;2;5;6;3;6;7;4;3;6;4;4;5;2;4;2;2;4;7;4;4;5;4;4;4;5;4;4;6;5;4;5;5;7;6;3;5;5;5;5;5;5;4;3;5;4;3;2;3;7;3; GO:0031974;GO:0030880;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0005666;GO:0044424;GO:0044422;GO:0044464;GO:0043229;GO:0043227;GO:0005654;GO:0055029;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044451;GO:0061695;GO:0000428;GO:0005623;GO:0005622;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;RNA polymerase complex;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;DNA-directed RNA polymerase III complex;intracellular part;organelle part;cell part;intracellular organelle;membrane-bounded organelle;nucleoplasm;nuclear DNA-directed RNA polymerase complex;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nucleoplasm part;transferase complex, transferring phosphorus-containing groups;DNA-directed RNA polymerase complex;cell;intracellular;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;4;5;4;5;3;4;3;5;4;6;3;2;2;3;3;5;5;3;4;4;5;5;6;5;2;3;2;2;1;4; GO:0016740;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901363;GO:0003824;GO:0016779;GO:0097159;GO:0034062;GO:0016772;GO:0003899; transferase activity;molecular_function;binding;nucleic acid binding;DNA binding;heterocyclic compound binding;catalytic activity;nucleotidyltransferase activity;organic cyclic compound binding;RNA polymerase activity;transferase activity, transferring phosphorus-containing groups;DNA-directed RNA polymerase activity; 3;1;2;4;5;3;2;5;3;6;4;7; K03023 map00230;map00240;map01100;map03020;map04623;map05169; Purine metabolism;Pyrimidine metabolism;Metabolic pathways;RNA polymerase;Cytosolic DNA-sensing pathway;Epstein-Barr virus infection; IPR013197;IPR008806;IPR011991; RNA polymerase III subunit RPC82-related, helix-turn-helix;RNA polymerase III Rpc82, C -terminal;Winged helix-turn-helix DNA-binding domain; cytosol Hs21359969 1110.0 K [K] Transcription; P28288 ATP-binding cassette sub-family D member 3 OS=Homo sapiens OX=9606 GN=ABCD3 PE=1 SV=1 - [ABCD3_HUMAN] 0.78 0.827 1.705 0.978 0.747 1.054 0.943168077 nan 1.309236948 nan 2.061668682 nan 1.410977242 nan GO:0034440;GO:0006820;GO:0044281;GO:0044282;GO:0044283;GO:0042760;GO:0071840;GO:0044712;GO:0044710;GO:0033036;GO:0015718;GO:0015849;GO:0015711;GO:0032787;GO:0072329;GO:0043436;GO:0010876;GO:0010033;GO:0055114;GO:0016054;GO:0042493;GO:0015910;GO:0016053;GO:0009062;GO:0072330;GO:0015908;GO:1901576;GO:1901575;GO:0016043;GO:0016042;GO:0014070;GO:0015909;GO:0006629;GO:0006811;GO:0006810;GO:0044711;GO:0008150;GO:0008152;GO:0000038;GO:0019395;GO:0051234;GO:0046394;GO:0046395;GO:0044765;GO:0006633;GO:0006631;GO:0006635;GO:0006869;GO:0044248;GO:0044249;GO:0044242;GO:0044699;GO:0046942;GO:0009987;GO:0044255;GO:0030258;GO:0055085;GO:0007031;GO:0006082;GO:0050896;GO:0019752;GO:0071704;GO:0071702;GO:0009058;GO:0044763;GO:0042221;GO:0009056;GO:0051179;GO:1902578;GO:0008610;GO:0006996;GO:0044238;GO:0044237; lipid oxidation;anion transport;small molecule metabolic process;small molecule catabolic process;small molecule biosynthetic process;very long-chain fatty acid catabolic process;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;macromolecule localization;monocarboxylic acid transport;organic acid transport;organic anion transport;monocarboxylic acid metabolic process;monocarboxylic acid catabolic process;oxoacid metabolic process;lipid localization;response to organic substance;oxidation-reduction process;organic acid catabolic process;response to drug;peroxisomal long-chain fatty acid import;organic acid biosynthetic process;fatty acid catabolic process;monocarboxylic acid biosynthetic process;fatty acid transport;organic substance biosynthetic process;organic substance catabolic process;cellular component organization;lipid catabolic process;response to organic cyclic compound;long-chain fatty acid transport;lipid metabolic process;ion transport;transport;single-organism biosynthetic process;biological_process;metabolic process;very long-chain fatty acid metabolic process;fatty acid oxidation;establishment of localization;carboxylic acid biosynthetic process;carboxylic acid catabolic process;single-organism transport;fatty acid biosynthetic process;fatty acid metabolic process;fatty acid beta-oxidation;lipid transport;cellular catabolic process;cellular biosynthetic process;cellular lipid catabolic process;single-organism process;carboxylic acid transport;cellular process;cellular lipid metabolic process;lipid modification;transmembrane transport;peroxisome organization;organic acid metabolic process;response to stimulus;carboxylic acid metabolic process;organic substance metabolic process;organic substance transport;biosynthetic process;single-organism cellular process;response to chemical;catabolic process;localization;single-organism localization;lipid biosynthetic process;organelle organization;primary metabolic process;cellular metabolic process; 5;6;4;5;5;7;2;4;3;3;7;5;6;7;7;5;4;4;4;5;4;8;5;6;7;6;4;4;3;5;5;7;4;5;4;4;1;2;6;6;3;6;6;4;6;5;7;5;4;4;5;2;6;2;4;5;4;5;4;2;6;3;5;3;3;3;3;2;3;5;4;3;3; GO:0005782;GO:0031974;GO:0031975;GO:0005778;GO:0016021;GO:0016020;GO:0005777;GO:0031907;GO:0031903;GO:0098588;GO:0031967;GO:0043231;GO:0042579;GO:0043233;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0044439;GO:0044438;GO:0031224;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0005829;GO:0098805;GO:0043226;GO:0031966;GO:0005575;GO:0070013;GO:0019866; peroxisomal matrix;membrane-enclosed lumen;envelope;peroxisomal membrane;integral component of membrane;membrane;peroxisome;microbody lumen;microbody membrane;bounding membrane of organelle;organelle envelope;intracellular membrane-bounded organelle;microbody;organelle lumen;mitochondrial part;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;peroxisomal part;microbody part;intrinsic component of membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;mitochondrion;cell part;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;cytosol;whole membrane;organelle;mitochondrial membrane;cellular_component;intracellular organelle lumen;organelle inner membrane; 6;2;3;5;4;2;6;5;4;4;4;4;5;3;4;3;2;2;3;3;5;4;3;3;4;4;3;5;2;2;3;5;5;5;3;2;4;1;4;4; GO:0000166;GO:0005319;GO:0016818;GO:0097367;GO:0016817;GO:0015245;GO:0015405;GO:0005324;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042623;GO:0015399;GO:0032549;GO:0017076;GO:0022804;GO:0016787;GO:0030554;GO:0003824;GO:0022892;GO:0043492;GO:0016462;GO:0032559;GO:0032555;GO:0046983;GO:0032550;GO:0032553;GO:0035639;GO:0005524;GO:0016820;GO:0043167;GO:0042802;GO:0042803;GO:0005215;GO:0042626;GO:0005515;GO:0097159;GO:1901363;GO:0001883;GO:0001882;GO:0017111;GO:0036094;GO:0043168;GO:0022857; nucleotide binding;lipid transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;fatty acid transporter activity;P-P-bond-hydrolysis-driven transmembrane transporter activity;long-chain fatty acid transporter activity;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase activity, coupled;primary active transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;active transmembrane transporter activity;hydrolase activity;adenyl nucleotide binding;catalytic activity;substrate-specific transporter activity;ATPase activity, coupled to movement of substances;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;protein dimerization activity;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ATP binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ion binding;identical protein binding;protein homodimerization activity;transporter activity;ATPase activity, coupled to transmembrane movement of substances;protein binding;organic cyclic compound binding;heterocyclic compound binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;anion binding;transmembrane transporter activity; 4;4;5;3;4;5;6;6;1;2;8;4;9;5;5;5;4;3;6;2;3;10;6;6;5;4;6;4;5;6;5;3;4;5;2;6;3;3;3;5;4;7;3;4;3; K05677 map02010;map04146; ABC transporters;Peroxisome; IPR017871;IPR003593;IPR005283;IPR003439;IPR011527;IPR031241;IPR027417; ABC transporter, conserved site;AAA+ ATPase domain;Peroxysomal long chain fatty acyl transporter;ABC transporter-like;ABC transporter type 1, transmembrane domain;ATP-binding cassette sub-family D member 3;P-loop containing nucleoside triphosphate hydrolase; mitochondria Hs4506341 1363.0 IR [I] Lipid transport and metabolism;[R] General function prediction only; Q9UQN3 Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1 - [CHM2B_HUMAN] 0.791 1.301 0.955 0.993 1.129 0.704 0.607993851 0.093513649 0.879539415 0.532364832 0.73405073 0.604618045 0.623560673 0.298910036 GO:0008104;GO:0044699;GO:0071702;GO:0033036;GO:0006810;GO:0045184;GO:0015031;GO:0044765;GO:0008150;GO:0051649;GO:0051234;GO:0051179;GO:1902578;GO:0051641;GO:0046907;GO:0007034;GO:1902582; protein localization;single-organism process;organic substance transport;macromolecule localization;transport;establishment of protein localization;protein transport;single-organism transport;biological_process;establishment of localization in cell;establishment of localization;localization;single-organism localization;cellular localization;intracellular transport;vacuolar transport;single-organism intracellular transport; 4;2;5;3;4;4;5;4;1;4;3;2;3;3;5;6;5; GO:0043229;GO:0043227;GO:0043226;GO:0010008;GO:0005737;GO:0016020;GO:0031090;GO:0005773;GO:0098805;GO:0005770;GO:0005774;GO:0044437;GO:0031902;GO:0098588;GO:0044446;GO:0012505;GO:0043231;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044440;GO:0044424;GO:0005768;GO:0044422; intracellular organelle;membrane-bounded organelle;organelle;endosome membrane;cytoplasm;membrane;organelle membrane;vacuole;whole membrane;late endosome;vacuolar membrane;vacuolar part;late endosome membrane;bounding membrane of organelle;intracellular organelle part;endomembrane system;intracellular membrane-bounded organelle;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;endosomal part;intracellular part;endosome;organelle part; 3;3;2;5;4;2;3;5;3;5;4;4;6;4;3;3;4;5;2;2;3;1;4;5;3;4;2; K12192 map04144; Endocytosis; IPR005024; Snf7 family; cytosol Hs14721561 427.0 U [U] Intracellular trafficking, secretion, and vesicular transport; P55103 Inhibin beta C chain OS=Homo sapiens OX=9606 GN=INHBC PE=2 SV=1 - [INHBC_HUMAN] 1.087 1.012 0.957 1.333 0.923 0.816 1.074110672 nan 1.444203684 nan 0.945652174 nan 0.884073673 nan GO:0019220;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0007165;GO:0007166;GO:0007167;GO:0023014;GO:0051716;GO:0010604;GO:0009966;GO:0048869;GO:0000165;GO:0048518;GO:0060255;GO:0048468;GO:0007178;GO:0042325;GO:0044700;GO:0042327;GO:0019538;GO:0060395;GO:0060393;GO:0009893;GO:0006468;GO:0035556;GO:0010862;GO:0050789;GO:0044267;GO:0044260;GO:0060389;GO:0065007;GO:0044710;GO:0050794;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:1902531;GO:0044767;GO:0050896;GO:0031401;GO:0009967;GO:0016310;GO:0030154;GO:0023056;GO:0023052;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0043408;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0031325;GO:0032502;GO:0009987;GO:0032268;GO:0043170;GO:0031323;GO:0008219;GO:0010941;GO:0042981;GO:0071704;GO:0043067;GO:0090092;GO:0045937;GO:0006915;GO:0006464;GO:0051174;GO:0044763;GO:0007154;GO:0044238;GO:0090100;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;signal transduction by protein phosphorylation;cellular response to stimulus;positive regulation of macromolecule metabolic process;regulation of signal transduction;cellular developmental process;MAPK cascade;positive regulation of biological process;regulation of macromolecule metabolic process;cell development;transmembrane receptor protein serine/threonine kinase signaling pathway;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;protein metabolic process;SMAD protein signal transduction;regulation of pathway-restricted SMAD protein phosphorylation;positive regulation of metabolic process;protein phosphorylation;intracellular signal transduction;positive regulation of pathway-restricted SMAD protein phosphorylation;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;pathway-restricted SMAD protein phosphorylation;biological regulation;single-organism metabolic process;regulation of cellular process;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of intracellular signal transduction;single-organism developmental process;response to stimulus;positive regulation of protein modification process;positive regulation of signal transduction;phosphorylation;cell differentiation;positive regulation of signaling;signaling;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MAPK cascade;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;positive regulation of cellular metabolic process;developmental process;cellular process;regulation of cellular protein metabolic process;macromolecule metabolic process;regulation of cellular metabolic process;cell death;regulation of cell death;regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;positive regulation of phosphate metabolic process;apoptotic process;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;cell communication;primary metabolic process;positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;4;3;3;3;4;5;6;4;3;4;4;4;5;2;4;4;7;7;3;7;4;5;6;3;7;5;6;2;5;4;8;2;3;3;5;5;5;1;2;5;3;2;6;4;6;5;3;2;3;4;4;2;6;5;5;5;5;6;4;2;2;5;4;4;4;4;6;3;5;5;6;6;6;5;3;4;3;5;3;3;5;4;7;7;3; GO:0043230;GO:0044421;GO:0043227;GO:0031982;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; extracellular organelle;extracellular region part;membrane-bounded organelle;vesicle;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 3;2;3;4;4;2;3;3;1;2; GO:0005126;GO:0005125;GO:0003674;GO:0005488;GO:0005515;GO:0005102;GO:0005160; cytokine receptor binding;cytokine activity;molecular_function;binding;protein binding;receptor binding;transforming growth factor beta receptor binding; 5;5;1;2;3;4;6; K22688 IPR015615;IPR001839;IPR017948;IPR029034;IPR001318; Transforming growth factor-beta-related;Transforming growth factor-beta, C-terminal;Transforming growth factor beta, conserved site;Cystine-knot cytokine;Inhibin, beta C subunit; extracellular Hs5031795 723.0 T [T] Signal transduction mechanisms; Q8TCX1 Cytoplasmic dynein 2 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC2LI1 PE=1 SV=1 - [DC2L1_HUMAN] 0.882 0.834 1.262 0.813 1.267 1.042 1.057553957 0.758395247 0.641673244 0.059859378 1.513189448 0.165310007 0.822415154 0.525137932 GO:0061024;GO:0016043;GO:1901576;GO:0032989;GO:0044707;GO:0071840;GO:0044710;GO:0048869;GO:0007368;GO:0018196;GO:0018193;GO:0002504;GO:0016192;GO:0019538;GO:0002376;GO:0044782;GO:0032990;GO:0022607;GO:0009101;GO:0048002;GO:0006888;GO:0000902;GO:0044260;GO:0048193;GO:0048646;GO:0019882;GO:0042384;GO:0019884;GO:0019886;GO:0006810;GO:0043412;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0044723;GO:0051234;GO:0046907;GO:0009058;GO:0043413;GO:0002495;GO:0010927;GO:0044249;GO:0034645;GO:0009799;GO:0009653;GO:0044699;GO:0032502;GO:0032501;GO:0043687;GO:0009987;GO:0060271;GO:0005975;GO:0048858;GO:1901137;GO:1901135;GO:0043170;GO:0030030;GO:0030031;GO:0009100;GO:0007275;GO:0007389;GO:0006486;GO:0002478;GO:0071704;GO:0018279;GO:0044267;GO:0070085;GO:0044767;GO:0044765;GO:0009059;GO:0044763;GO:0051649;GO:0070925;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0006487;GO:0048856;GO:0044237;GO:1902589;GO:0044085;GO:0009855;GO:1902582; membrane organization;cellular component organization;organic substance biosynthetic process;cellular component morphogenesis;single-multicellular organism process;cellular component organization or biogenesis;single-organism metabolic process;cellular developmental process;determination of left/right symmetry;peptidyl-asparagine modification;peptidyl-amino acid modification;antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;vesicle-mediated transport;protein metabolic process;immune system process;cilium organization;cell part morphogenesis;cellular component assembly;glycoprotein biosynthetic process;antigen processing and presentation of peptide antigen;ER to Golgi vesicle-mediated transport;cell morphogenesis;cellular macromolecule metabolic process;Golgi vesicle transport;anatomical structure formation involved in morphogenesis;antigen processing and presentation;cilium assembly;antigen processing and presentation of exogenous antigen;antigen processing and presentation of exogenous peptide antigen via MHC class II;transport;macromolecule modification;protein modification process;biological_process;cellular protein modification process;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;intracellular transport;biosynthetic process;macromolecule glycosylation;antigen processing and presentation of peptide antigen via MHC class II;cellular component assembly involved in morphogenesis;cellular biosynthetic process;cellular macromolecule biosynthetic process;specification of symmetry;anatomical structure morphogenesis;single-organism process;developmental process;multicellular organismal process;post-translational protein modification;cellular process;cilium morphogenesis;carbohydrate metabolic process;cell projection morphogenesis;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;cell projection organization;cell projection assembly;glycoprotein metabolic process;multicellular organism development;pattern specification process;protein glycosylation;antigen processing and presentation of exogenous peptide antigen;organic substance metabolic process;protein N-linked glycosylation via asparagine;cellular protein metabolic process;glycosylation;single-organism developmental process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;organelle assembly;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;protein N-linked glycosylation;anatomical structure development;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;determination of bilateral symmetry;single-organism intracellular transport; 4;3;4;4;3;2;3;4;7;8;7;4;5;4;2;5;5;4;6;4;7;5;4;6;3;3;5;4;6;4;5;5;1;6;2;4;3;5;3;6;5;4;4;5;5;3;2;2;2;7;2;6;4;5;5;4;4;4;5;5;4;4;4;5;3;6;5;5;3;4;5;3;4;5;2;3;3;4;3;5;3;3;4;3;6;5; GO:0099512;GO:0099513;GO:1902494;GO:0042995;GO:0043234;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0030286;GO:0005622;GO:0043226;GO:0005856;GO:0036064;GO:0005858;GO:0044430;GO:0005930;GO:0044446;GO:0044444;GO:0097014;GO:0044441;GO:0031512;GO:0005874;GO:0005875;GO:0005737;GO:0045177;GO:0097542;GO:0044463;GO:0044464;GO:0005623;GO:0072372;GO:0044447;GO:0005815;GO:0015630;GO:0030990;GO:0032991;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;catalytic complex;cell projection;protein complex;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;dynein complex;intracellular;organelle;cytoskeleton;ciliary basal body;axonemal dynein complex;cytoskeletal part;axoneme;intracellular organelle part;cytoplasmic part;ciliary plasm;ciliary part;motile primary cilium;microtubule;microtubule associated complex;cytoplasm;apical part of cell;ciliary tip;cell projection part;cell part;cell;primary cilium;axoneme part;microtubule organizing center;microtubule cytoskeleton;intraciliary transport particle;macromolecular complex;cellular_component; 2;3;4;3;3;4;5;3;2;3;3;3;5;3;2;5;4;5;4;4;3;4;4;3;5;4;4;4;3;4;3;2;2;4;4;5;6;4;2;1; GO:0016818;GO:0016817;GO:0003674;GO:0005488;GO:0003774;GO:0016787;GO:0003824;GO:0016462;GO:0045502;GO:0045504;GO:0005515;GO:0017111; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;molecular_function;binding;motor activity;hydrolase activity;catalytic activity;pyrophosphatase activity;dynein binding;dynein heavy chain binding;protein binding;nucleoside-triphosphatase activity; 5;4;1;2;8;3;2;6;4;5;3;7; K10417 map04962; Vasopressin-regulated water reabsorption; IPR022780;IPR027417; Dynein family light intermediate chain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs14727149 723.0 S [S] Function unknown; Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3 - [HSC20_HUMAN] 1.026 0.922 1.17 1.021 0.953 1.225 1.112798265 nan 1.07135362 nan 1.268980477 nan 1.285414481 nan GO:0022607;GO:0006457;GO:0070271;GO:0043933;GO:0044237;GO:0044249;GO:0071840;GO:0051186;GO:0071822;GO:0051188;GO:0016043;GO:0065003;GO:0006461;GO:0009987;GO:0016226;GO:0009058;GO:0008150;GO:0008152;GO:0051259;GO:0031163;GO:0044085;GO:0006790; cellular component assembly;protein folding;protein complex biogenesis;macromolecular complex subunit organization;cellular metabolic process;cellular biosynthetic process;cellular component organization or biogenesis;cofactor metabolic process;protein complex subunit organization;cofactor biosynthetic process;cellular component organization;macromolecular complex assembly;protein complex assembly;cellular process;iron-sulfur cluster assembly;biosynthetic process;biological_process;metabolic process;protein oligomerization;metallo-sulfur cluster assembly;cellular component biogenesis;sulfur compound metabolic process; 4;3;4;4;3;4;2;4;5;5;3;5;5;2;5;3;1;2;6;5;3;4; GO:0043229;GO:0005739;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; intracellular organelle;mitochondrion;membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 3;5;3;2;4;5;4;2;2;3;1;4;3; GO:0003674;GO:0005488;GO:0043169;GO:0051087;GO:0043167;GO:0046872;GO:0005515; molecular_function;binding;cation binding;chaperone binding;ion binding;metal ion binding;protein binding; 1;2;4;4;3;5;3; K04082 IPR001623;IPR004640;IPR009073; DnaJ domain;Co-chaperone Hsc20;Co-chaperone HscB, C-terminal oligomerisation domain; mitochondria At5g06410 127.0 O [O] Posttranslational modification, protein turnover, chaperones; Q8N283 Ankyrin repeat domain-containing protein 35 OS=Homo sapiens OX=9606 GN=ANKRD35 PE=2 SV=2 - [ANR35_HUMAN] 0.959 1.126 0.733 1.078 1.237 0.727 0.851687389 0.2325589 0.871463217 0.589912238 0.650976909 0.829914913 0.587712207 0.843919311 IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; mitochondria 189501781 121.0 R [R] General function prediction only; COG1672 Predicted ATPase, archaeal AAA+ ATPase superfamily Q9NWA0 Mediator of RNA polymerase II transcription subunit 9 OS=Homo sapiens OX=9606 GN=MED9 PE=1 SV=1 - [MED9_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0032774;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:0044237;GO:0034645;GO:0043170;GO:0097659;GO:1901362;GO:0071704;GO:0010467;GO:1901360;GO:0018130;GO:0016070;GO:1901576;GO:0009987;GO:0006725;GO:0044260;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:0034654;GO:0044271;GO:0034641;GO:0046483;GO:0044238;GO:0006351;GO:0019438; RNA biosynthetic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;nucleic acid-templated transcription;organic cyclic compound biosynthetic process;organic substance metabolic process;gene expression;organic cyclic compound metabolic process;heterocycle biosynthetic process;RNA metabolic process;organic substance biosynthetic process;cellular process;cellular aromatic compound metabolic process;cellular macromolecule metabolic process;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound metabolic process;heterocycle metabolic process;primary metabolic process;transcription, DNA-templated;aromatic compound biosynthetic process; 6;4;5;4;3;3;5;4;7;5;3;5;4;5;5;4;2;4;4;3;5;1;2;5;5;4;4;3;6;5; GO:0031974;GO:0043229;GO:0016592;GO:0043227;GO:0043226;GO:0044446;GO:0031981;GO:0005634;GO:0005654;GO:0044451;GO:0043234;GO:0032991;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;mediator complex;membrane-bounded organelle;organelle;intracellular organelle part;nuclear lumen;nucleus;nucleoplasm;nucleoplasm part;protein complex;macromolecular complex;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;4;3;2;3;5;5;5;5;3;2;4;3;2;2;3;1;4;4;3;2; GO:0003674;GO:0003712;GO:0000989;GO:0000988;GO:0001104;GO:0001076; molecular_function;transcription cofactor activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;RNA polymerase II transcription cofactor activity;transcription factor activity, RNA polymerase II transcription factor binding; 1;4;3;2;5;4; K15149 IPR011425; Mediator of RNA polymerase II transcription subunit 9; cytosol P24158 Myeloblastin OS=Homo sapiens OX=9606 GN=PRTN3 PE=1 SV=3 - [PRTN3_HUMAN] 1.292 0.824 1.048 1.315 0.775 0.854 1.567961165 nan 1.696774194 nan 1.27184466 nan 1.101935484 nan GO:0006909;GO:0051049;GO:0007596;GO:0007599;GO:0002573;GO:0071840;GO:0044712;GO:0044710;GO:0048869;GO:0009611;GO:0048513;GO:0048518;GO:0048519;GO:0042127;GO:0051051;GO:0016192;GO:0044707;GO:0002376;GO:0050789;GO:0016043;GO:0065007;GO:0065008;GO:0006810;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0030097;GO:0051234;GO:0002521;GO:0002520;GO:0006897;GO:0050896;GO:0030574;GO:0030154;GO:0051129;GO:0051128;GO:0032963;GO:0044243;GO:0044699;GO:0050764;GO:0050765;GO:0030100;GO:0097028;GO:0097029;GO:0008284;GO:0032501;GO:0050878;GO:0008283;GO:0009987;GO:0060627;GO:0044259;GO:0032879;GO:0043170;GO:0030099;GO:0048731;GO:0032502;GO:0007275;GO:0071704;GO:0048534;GO:0044767;GO:0044765;GO:0044763;GO:0009056;GO:0051179;GO:1902578;GO:0048856;GO:0044236;GO:0045806;GO:0048523;GO:0048522; phagocytosis;regulation of transport;blood coagulation;hemostasis;myeloid leukocyte differentiation;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;cellular developmental process;response to wounding;animal organ development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;negative regulation of transport;vesicle-mediated transport;single-multicellular organism process;immune system process;regulation of biological process;cellular component organization;biological regulation;regulation of biological quality;transport;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;hemopoiesis;establishment of localization;leukocyte differentiation;immune system development;endocytosis;response to stimulus;collagen catabolic process;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;collagen metabolic process;multicellular organism catabolic process;single-organism process;regulation of phagocytosis;negative regulation of phagocytosis;regulation of endocytosis;dendritic cell differentiation;mature conventional dendritic cell differentiation;positive regulation of cell proliferation;multicellular organismal process;regulation of body fluid levels;cell proliferation;cellular process;regulation of vesicle-mediated transport;multicellular organismal macromolecule metabolic process;regulation of localization;macromolecule metabolic process;myeloid cell differentiation;system development;developmental process;multicellular organism development;organic substance metabolic process;hematopoietic or lymphoid organ development;single-organism developmental process;single-organism transport;single-organism cellular process;catabolic process;localization;single-organism localization;anatomical structure development;multicellular organism metabolic process;negative regulation of endocytosis;negative regulation of cellular process;positive regulation of cellular process; 5;4;5;5;7;2;4;3;4;4;4;2;2;4;3;5;3;2;2;3;2;3;4;5;3;3;4;1;2;5;3;6;3;6;2;5;5;4;4;6;5;2;6;5;5;7;8;4;2;4;3;2;4;5;3;4;6;4;2;4;3;4;3;4;3;3;2;3;3;4;4;3;3; GO:0031982;GO:0016020;GO:0043230;GO:0005829;GO:0044424;GO:0044421;GO:0005622;GO:0043227;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;cytosol;intracellular part;extracellular region part;intracellular;membrane-bounded organelle;cytoplasmic part;cytoplasm;cell part;cell;cell periphery;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;2;3;5;3;2;3;3;4;4;2;2;3;4;2;3;3;3;1;2; GO:0004252;GO:0017171;GO:0019899;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0005515;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;enzyme binding;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;protein binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;4;1;2;3;2;4;5;3;6;5; K01350 IPR033116;IPR009003;IPR001254;IPR018114;IPR001314; Serine proteases, trypsin family, serine active site;Peptidase S1, PA clan;Serine proteases, trypsin domain;Serine proteases, trypsin family, histidine active site;Peptidase S1A, chymotrypsin family; extracellular Hs7382458 520.0 E [E] Amino acid transport and metabolism; Q9Y4A5 Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3 - [TRRAP_HUMAN] 1.051 0.709 1.074 1.105 1.033 1.733 1.482369535 nan 1.069699903 nan 1.514809591 nan 1.677637948 nan GO:0080090;GO:0019222;GO:0043543;GO:0006473;GO:0006475;GO:1901362;GO:1901360;GO:0051716;GO:0070647;GO:0018193;GO:0016570;GO:0006281;GO:0060255;GO:2001141;GO:0046483;GO:0019538;GO:0018205;GO:0033554;GO:0019438;GO:0016573;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0043967;GO:0018394;GO:0016043;GO:0065007;GO:0071840;GO:0016579;GO:0016578;GO:0018130;GO:0018393;GO:0043968;GO:0009889;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0043412;GO:0006355;GO:0010556;GO:0006351;GO:0016569;GO:0032774;GO:0016310;GO:0070646;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0006508;GO:0009987;GO:0006725;GO:1903506;GO:0006974;GO:0051252;GO:0043170;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0006325;GO:2000112;GO:1902589;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0044267;GO:0019219;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0016568;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0006796;GO:0006793;GO:0006259; regulation of primary metabolic process;regulation of metabolic process;protein acylation;protein acetylation;internal protein amino acid acetylation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;protein modification by small protein conjugation or removal;peptidyl-amino acid modification;histone modification;DNA repair;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;protein metabolic process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;histone acetylation;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;histone H4 acetylation;peptidyl-lysine acetylation;cellular component organization;biological regulation;cellular component organization or biogenesis;protein deubiquitination;histone deubiquitination;heterocycle biosynthetic process;internal peptidyl-lysine acetylation;histone H2A acetylation;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;macromolecule modification;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;covalent chromatin modification;RNA biosynthetic process;phosphorylation;protein modification by small protein removal;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;proteolysis;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;regulation of RNA metabolic process;macromolecule metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;regulation of cellular macromolecule biosynthetic process;single-organism organelle organization;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;chromatin modification;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;DNA metabolic process; 4;3;7;8;9;5;4;3;7;7;4;4;4;6;4;4;8;4;5;5;3;7;4;4;6;9;3;2;2;7;5;5;10;6;4;3;3;3;5;1;2;5;5;5;2;5;6;5;6;7;6;6;6;4;4;5;2;4;5;2;4;7;5;5;4;4;5;4;5;5;6;4;2;3;5;5;5;5;6;3;5;3;4;6;4;3;5;3;5;4;5; GO:0031974;GO:0035267;GO:1902562;GO:0016591;GO:0030880;GO:0031981;GO:0030914;GO:0005794;GO:1902493;GO:1902494;GO:0000790;GO:1990234;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0090575;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0031248;GO:0000428;GO:0043229;GO:0000228;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0005737;GO:0005667;GO:0055029;GO:0012505;GO:0044446;GO:0044444;GO:0000125;GO:0070603;GO:0000123;GO:0044454;GO:0005634;GO:0044798;GO:0033276;GO:0044451;GO:0061695;GO:0044464;GO:0005623;GO:0070461;GO:0043228;GO:0000785;GO:0043189;GO:0097346;GO:0005694;GO:0032991;GO:0005575;GO:0070013;GO:0000812; membrane-enclosed lumen;NuA4 histone acetyltransferase complex;H4 histone acetyltransferase complex;DNA-directed RNA polymerase II, holoenzyme;RNA polymerase complex;nuclear lumen;STAGA complex;Golgi apparatus;acetyltransferase complex;catalytic complex;nuclear chromatin;transferase complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;RNA polymerase II transcription factor complex;nuclear part;intracellular part;chromosomal part;organelle part;protein acetyltransferase complex;DNA-directed RNA polymerase complex;intracellular organelle;nuclear chromosome;intracellular;membrane-bounded organelle;organelle;nucleoplasm;cytoplasm;transcription factor complex;nuclear DNA-directed RNA polymerase complex;endomembrane system;intracellular organelle part;cytoplasmic part;PCAF complex;SWI/SNF superfamily-type complex;histone acetyltransferase complex;nuclear chromosome part;nucleus;nuclear transcription factor complex;transcription factor TFTC complex;nucleoplasm part;transferase complex, transferring phosphorus-containing groups;cell part;cell;SAGA-type complex;non-membrane-bounded organelle;chromatin;H4/H2A histone acetyltransferase complex;INO80-type complex;chromosome;macromolecular complex;cellular_component;intracellular organelle lumen;Swr1 complex; 2;8;6;6;4;5;7;4;6;4;4;5;3;4;4;3;6;4;3;4;2;4;5;3;5;3;3;2;5;4;4;5;3;3;4;7;4;5;5;5;5;7;5;6;2;2;6;3;3;7;5;5;2;1;4;5; GO:0003712;GO:0016740;GO:0003674;GO:0000989;GO:0000988;GO:0016301;GO:0003824;GO:0016773;GO:0016772; transcription cofactor activity;transferase activity;molecular_function;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups; 4;3;1;3;2;5;2;5;4; K08874 map05166; HTLV-I infection; IPR016024;IPR011009;IPR033317;IPR000403;IPR011990;IPR003151;IPR003152;IPR011989;IPR014009; Armadillo-type fold;Protein kinase-like domain;Transcription-associated protein 1;Phosphatidylinositol 3-/4-kinase, catalytic domain;Tetratricopeptide-like helical domain;PIK-related kinase, FAT;FATC domain;Armadillo-like helical;PIK-related kinase; plasma membrane Hs4507691 7954.0 TBLD [T] Signal transduction mechanisms;[B] Chromatin structure and dynamics;[L] Replication, recombination and repair;[D] Cell cycle control, cell division, chromosome partitioning; Q86UK7 E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1 - [ZN598_HUMAN] 0.94 0.983 1.243 0.856 1.018 0.969 0.956256358 0.854626614 0.84086444 0.289848219 1.264496439 0.049255551 0.951866405 0.813453569 GO:0043169;GO:0046914;GO:0097159;GO:0044822;GO:0008270;GO:0043167;GO:0003674;GO:0003723;GO:0003676;GO:0046872;GO:1901363;GO:0005488; cation binding;transition metal ion binding;organic cyclic compound binding;poly(A) RNA binding;zinc ion binding;ion binding;molecular_function;RNA binding;nucleic acid binding;metal ion binding;heterocyclic compound binding;binding; 4;6;3;6;7;3;1;5;4;5;3;2; K22381 IPR013087;IPR001841;IPR013083; Zinc finger C2H2-type;Zinc finger, RING-type;Zinc finger, RING/FYVE/PHD-type; nucleus Hs22068519 1724.0 O [O] Posttranslational modification, protein turnover, chaperones; P45379 Troponin T, cardiac muscle OS=Homo sapiens OX=9606 GN=TNNT2 PE=1 SV=3 - [TNNT2_HUMAN] 1.083 1.105 0.841 1.245 0.957 1.139 0.980090498 nan 1.300940439 nan 0.761085973 nan 1.190177638 nan GO:0010038;GO:0051049;GO:0032386;GO:0003012;GO:0072358;GO:0003015;GO:0071840;GO:0007517;GO:0048513;GO:0044093;GO:0044092;GO:0006936;GO:0006937;GO:0032780;GO:0032781;GO:0051291;GO:0030049;GO:0030048;GO:0051592;GO:0010035;GO:0003008;GO:0006941;GO:0044707;GO:0072359;GO:0003013;GO:0060415;GO:0022607;GO:0006928;GO:0050789;GO:0003205;GO:0003206;GO:0051346;GO:0051345;GO:0003208;GO:0016043;GO:0065003;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0048644;GO:0009887;GO:0050790;GO:0008016;GO:0008015;GO:0006810;GO:0009888;GO:0050794;GO:0008150;GO:0051239;GO:0003231;GO:0051234;GO:0051336;GO:0046907;GO:0050896;GO:1903522;GO:0070271;GO:0003007;GO:0060047;GO:0003229;GO:0051764;GO:0061061;GO:0009653;GO:0060048;GO:0043086;GO:0044699;GO:0044057;GO:0033275;GO:0032502;GO:0032501;GO:1903115;GO:0007015;GO:0055008;GO:0032972;GO:0032971;GO:0032970;GO:0032879;GO:0051259;GO:0048738;GO:0048731;GO:0060341;GO:0055010;GO:0043933;GO:0030036;GO:0014706;GO:0007275;GO:0043462;GO:0071822;GO:0048729;GO:0009987;GO:0030029;GO:0006461;GO:0044767;GO:0044763;GO:0090257;GO:0051649;GO:0042221;GO:0051179;GO:0051641;GO:0006996;GO:0007507;GO:0051270;GO:0007010;GO:0048856;GO:1902589;GO:0044085;GO:0060537;GO:0070252; response to metal ion;regulation of transport;regulation of intracellular transport;muscle system process;cardiovascular system development;heart process;cellular component organization or biogenesis;muscle organ development;animal organ development;positive regulation of molecular function;negative regulation of molecular function;muscle contraction;regulation of muscle contraction;negative regulation of ATPase activity;positive regulation of ATPase activity;protein heterooligomerization;muscle filament sliding;actin filament-based movement;response to calcium ion;response to inorganic substance;system process;striated muscle contraction;single-multicellular organism process;circulatory system development;circulatory system process;muscle tissue morphogenesis;cellular component assembly;movement of cell or subcellular component;regulation of biological process;cardiac chamber development;cardiac chamber morphogenesis;negative regulation of hydrolase activity;positive regulation of hydrolase activity;cardiac ventricle morphogenesis;cellular component organization;macromolecular complex assembly;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;muscle organ morphogenesis;organ morphogenesis;regulation of catalytic activity;regulation of heart contraction;blood circulation;transport;tissue development;regulation of cellular process;biological_process;regulation of multicellular organismal process;cardiac ventricle development;establishment of localization;regulation of hydrolase activity;intracellular transport;response to stimulus;regulation of blood circulation;protein complex biogenesis;heart morphogenesis;heart contraction;ventricular cardiac muscle tissue development;actin crosslink formation;muscle structure development;anatomical structure morphogenesis;cardiac muscle contraction;negative regulation of catalytic activity;single-organism process;regulation of system process;actin-myosin filament sliding;developmental process;multicellular organismal process;regulation of actin filament-based movement;actin filament organization;cardiac muscle tissue morphogenesis;regulation of muscle filament sliding speed;regulation of muscle filament sliding;regulation of actin filament-based process;regulation of localization;protein oligomerization;cardiac muscle tissue development;system development;regulation of cellular localization;ventricular cardiac muscle tissue morphogenesis;macromolecular complex subunit organization;actin cytoskeleton organization;striated muscle tissue development;multicellular organism development;regulation of ATPase activity;protein complex subunit organization;tissue morphogenesis;cellular process;actin filament-based process;protein complex assembly;single-organism developmental process;single-organism cellular process;regulation of muscle system process;establishment of localization in cell;response to chemical;localization;cellular localization;organelle organization;heart development;regulation of cellular component movement;cytoskeleton organization;anatomical structure development;single-organism organelle organization;cellular component biogenesis;muscle tissue development;actin-mediated cell contraction; 5;4;5;4;5;5;2;5;4;4;4;5;6;7;7;7;6;5;6;4;3;6;3;5;4;5;4;4;2;4;4;6;6;5;3;5;2;5;3;3;5;4;4;6;5;4;4;3;1;3;5;3;5;5;2;5;4;5;6;6;7;4;3;7;5;2;4;7;2;2;5;6;6;4;6;4;3;6;5;4;4;6;4;5;6;4;6;5;4;2;4;5;3;3;5;4;3;2;3;4;4;4;5;3;4;3;5;6; GO:0043234;GO:0036379;GO:0043232;GO:0005829;GO:0044424;GO:0043229;GO:0043228;GO:0044430;GO:0044446;GO:0044444;GO:0044422;GO:0044449;GO:0030016;GO:0030017;GO:0005737;GO:0032991;GO:0005865;GO:0005861;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0043226;GO:0005856;GO:0005575;GO:0043292; protein complex;myofilament;intracellular non-membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;intracellular organelle part;cytoplasmic part;organelle part;contractile fiber part;myofibril;sarcomere;cytoplasm;macromolecular complex;striated muscle thin filament;troponin complex;cell part;cell;intracellular;actin cytoskeleton;organelle;cytoskeleton;cellular_component;contractile fiber; 3;4;4;5;3;3;3;4;3;4;2;3;6;4;4;2;5;4;2;2;3;6;2;5;1;5; GO:0003779;GO:0003674;GO:0005488;GO:0030172;GO:0005523;GO:0008092;GO:0031013;GO:0005515; actin binding;molecular_function;binding;troponin C binding;tropomyosin binding;cytoskeletal protein binding;troponin I binding;protein binding; 5;1;2;5;5;4;5;3; K12045 map04260;map04261;map05410;map05414; Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy; IPR027707;IPR001978; Troponin T;Troponin; nucleus Hs4507627 550.0 Z [Z] Cytoskeleton; O00534 von Willebrand factor A domain-containing protein 5A OS=Homo sapiens OX=9606 GN=VWA5A PE=2 SV=2 - [VMA5A_HUMAN] 2.105 0.279 0.964 1.67 0.281 0.698 7.544802867 nan 5.943060498 nan 3.455197133 nan 2.483985765 nan GO:0005654;GO:0043231;GO:0031981;GO:0043233;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0043229;GO:0044428;GO:0031974;GO:0005575;GO:0044424;GO:0043227;GO:0043226;GO:0044422; nucleoplasm;intracellular membrane-bounded organelle;nuclear lumen;organelle lumen;nucleus;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;intracellular organelle;nuclear part;membrane-enclosed lumen;cellular_component;intracellular part;membrane-bounded organelle;organelle;organelle part; 5;4;5;3;5;2;2;3;3;4;3;4;2;1;3;3;2;2; IPR013694;IPR002035; VIT domain;von Willebrand factor, type A; nucleus 383452677 181.0 R [R] General function prediction only; COG2304 Secreted protein containing bacterial Ig-like domain and vWFA domain O43252 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2 - [PAPS1_HUMAN] 0.745 0.75 1.942 0.846 0.771 0.711 0.993333333 0.930293793 1.097276265 0.185519177 2.589333333 0.007182655 0.922178988 0.63057001 GO:0001501;GO:0009165;GO:0009163;GO:1901362;GO:0046129;GO:1901360;GO:0051716;GO:0044711;GO:0034032;GO:0043436;GO:0042451;GO:0046128;GO:0042455;GO:0046483;GO:1901564;GO:1901566;GO:0044707;GO:0034641;GO:0006163;GO:0006164;GO:0019438;GO:0044281;GO:0030203;GO:0006805;GO:0006807;GO:0043170;GO:1901576;GO:0019637;GO:0018130;GO:0044710;GO:0009152;GO:0009260;GO:0008150;GO:0008152;GO:0034654;GO:0009150;GO:0090407;GO:0044271;GO:0050896;GO:0033866;GO:0033865;GO:1901293;GO:0006022;GO:0009117;GO:0006753;GO:0044249;GO:0009410;GO:0070887;GO:0009259;GO:0044699;GO:0006139;GO:0042278;GO:0033875;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0050428;GO:0034035;GO:0050427;GO:0034030;GO:0055086;GO:0034033;GO:0006082;GO:1901137;GO:1901135;GO:0044272;GO:0048731;GO:0046390;GO:0019693;GO:0072521;GO:0072522;GO:0000103;GO:0007275;GO:0001887;GO:0071466;GO:0071704;GO:0034036;GO:0044767;GO:0009058;GO:0044763;GO:0009116;GO:0042221;GO:0009119;GO:0044238;GO:0005975;GO:0048856;GO:0044237;GO:1901657;GO:0006796;GO:0006790;GO:0006793;GO:1901659; skeletal system development;nucleotide biosynthetic process;nucleoside biosynthetic process;organic cyclic compound biosynthetic process;purine ribonucleoside biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;single-organism biosynthetic process;purine nucleoside bisphosphate metabolic process;oxoacid metabolic process;purine nucleoside biosynthetic process;purine ribonucleoside metabolic process;ribonucleoside biosynthetic process;heterocycle metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;single-multicellular organism process;cellular nitrogen compound metabolic process;purine nucleotide metabolic process;purine nucleotide biosynthetic process;aromatic compound biosynthetic process;small molecule metabolic process;glycosaminoglycan metabolic process;xenobiotic metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;organic substance biosynthetic process;organophosphate metabolic process;heterocycle biosynthetic process;single-organism metabolic process;purine ribonucleotide biosynthetic process;ribonucleotide biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;purine ribonucleotide metabolic process;organophosphate biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;nucleoside bisphosphate biosynthetic process;nucleoside bisphosphate metabolic process;nucleoside phosphate biosynthetic process;aminoglycan metabolic process;nucleotide metabolic process;nucleoside phosphate metabolic process;cellular biosynthetic process;response to xenobiotic stimulus;cellular response to chemical stimulus;ribonucleotide metabolic process;single-organism process;nucleobase-containing compound metabolic process;purine nucleoside metabolic process;ribonucleoside bisphosphate metabolic process;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;purine ribonucleoside bisphosphate metabolic process;3'-phosphoadenosine 5'-phosphosulfate metabolic process;ribonucleoside bisphosphate biosynthetic process;nucleobase-containing small molecule metabolic process;purine nucleoside bisphosphate biosynthetic process;organic acid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;sulfur compound biosynthetic process;system development;ribose phosphate biosynthetic process;ribose phosphate metabolic process;purine-containing compound metabolic process;purine-containing compound biosynthetic process;sulfate assimilation;multicellular organism development;selenium compound metabolic process;cellular response to xenobiotic stimulus;organic substance metabolic process;purine ribonucleoside bisphosphate biosynthetic process;single-organism developmental process;biosynthetic process;single-organism cellular process;nucleoside metabolic process;response to chemical;ribonucleoside metabolic process;primary metabolic process;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;glycosyl compound metabolic process;phosphate-containing compound metabolic process;sulfur compound metabolic process;phosphorus metabolic process;glycosyl compound biosynthetic process; 5;6;6;5;8;4;3;4;6;5;7;7;7;4;4;5;3;4;6;7;5;4;6;4;3;4;4;4;5;3;8;7;1;2;5;7;5;5;2;6;6;5;5;6;5;4;4;4;6;2;4;6;7;2;2;2;4;6;7;5;7;4;7;4;5;4;5;4;6;5;5;6;5;4;4;5;3;8;3;3;3;5;3;6;3;4;3;3;4;5;4;4;5; GO:0005829;GO:0044424;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575; cytosol;intracellular part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;cellular_component; 5;3;4;4;2;2;3;1; GO:0001883;GO:0000166;GO:0016740;GO:0004020;GO:0017076;GO:0004781;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0005524;GO:0043168;GO:0016301;GO:0036094;GO:0016779;GO:0003824;GO:0016773;GO:0016772;GO:0070566;GO:0032559;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0097159;GO:0001882;GO:0004779;GO:0032555; purine nucleoside binding;nucleotide binding;transferase activity;adenylylsulfate kinase activity;purine nucleotide binding;sulfate adenylyltransferase (ATP) activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;ATP binding;anion binding;kinase activity;small molecule binding;nucleotidyltransferase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenylyltransferase activity;adenyl ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;nucleoside binding;sulfate adenylyltransferase activity;purine ribonucleotide binding; 5;4;3;6;5;8;3;1;2;4;3;5;6;4;5;3;5;2;5;4;6;6;6;4;5;3;6;3;4;7;5; K13811 map00230;map00261;map00450;map00920;map01100;map01120;map01130; Purine metabolism;Monobactam biosynthesis;Selenocompound metabolism;Sulfur metabolism;Metabolic pathways;Microbial metabolism in diverse environments;Biosynthesis of antibiotics; IPR024951;IPR015947;IPR014729;IPR002650;IPR002891;IPR025980;IPR027417; Sulphate adenylyltransferase catalytic domain;PUA-like domain;Rossmann-like alpha/beta/alpha sandwich fold;Sulphate adenylyltransferase;Adenylyl-sulfate kinase;ATP-sulfurylase PUA-like domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs20127475 1309.0 F [F] Nucleotide transport and metabolism; Q6NUP7 Serine/threonine-protein phosphatase 4 regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PPP4R4 PE=1 SV=1 - [PP4R4_HUMAN] 0.955 1.249 0.687 1.347 1.182 0.714 0.764611689 nan 1.139593909 nan 0.550040032 nan 0.604060914 nan GO:0031324;GO:0019220;GO:0080090;GO:0019222;GO:0016311;GO:0010921;GO:0031323;GO:0043170;GO:0044092;GO:0044237;GO:0009892;GO:0010923;GO:0050789;GO:0044267;GO:0051248;GO:0010605;GO:0051346;GO:0044260;GO:0010563;GO:0051246;GO:0043086;GO:0071704;GO:0080163;GO:0065007;GO:0031399;GO:0048519;GO:0065009;GO:0009987;GO:0045936;GO:0050790;GO:0006464;GO:0050794;GO:0051174;GO:0035308;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0035303;GO:0035305;GO:0035304;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0043666;GO:0060255;GO:0031400;GO:0019538;GO:0006796;GO:0006470;GO:0006793;GO:0032515;GO:0048523; negative regulation of cellular metabolic process;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;dephosphorylation;regulation of phosphatase activity;regulation of cellular metabolic process;macromolecule metabolic process;negative regulation of molecular function;cellular metabolic process;negative regulation of metabolic process;negative regulation of phosphatase activity;regulation of biological process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;regulation of protein serine/threonine phosphatase activity;biological regulation;regulation of protein modification process;negative regulation of biological process;regulation of molecular function;cellular process;negative regulation of phosphate metabolic process;regulation of catalytic activity;cellular protein modification process;regulation of cellular process;regulation of phosphorus metabolic process;negative regulation of protein dephosphorylation;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of dephosphorylation;negative regulation of dephosphorylation;regulation of protein dephosphorylation;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of phosphoprotein phosphatase activity;regulation of macromolecule metabolic process;negative regulation of protein modification process;protein metabolic process;phosphate-containing compound metabolic process;protein dephosphorylation;phosphorus metabolic process;negative regulation of phosphoprotein phosphatase activity;negative regulation of cellular process; 4;6;4;3;6;6;4;4;4;3;3;7;2;5;5;4;6;4;5;5;5;3;8;2;6;2;3;2;6;4;6;3;5;7;5;5;1;2;7;7;7;5;3;5;5;7;4;6;4;5;7;4;8;3; GO:1903293;GO:0008287;GO:0005737;GO:0043234;GO:1902494;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; phosphatase complex;protein serine/threonine phosphatase complex;cytoplasm;protein complex;catalytic complex;macromolecular complex;cell part;cell;intracellular;cellular_component;intracellular part; 5;3;4;3;4;2;2;2;3;1;3; GO:0019208;GO:0003674;GO:0098772;GO:0019888;GO:0030234; phosphatase regulator activity;molecular_function;molecular function regulator;protein phosphatase regulator activity;enzyme regulator activity; 4;1;2;5;3; K15426 IPR021133;IPR016024;IPR011989; HEAT, type 2;Armadillo-type fold;Armadillo-like helical; nucleus Hs17402886 1799.0 T [T] Signal transduction mechanisms; P23588 Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2 - [IF4B_HUMAN] 1.12 1.031 0.967 1.243 0.886 0.968 1.086323957 nan 1.402934537 nan 0.937924345 nan 1.09255079 nan GO:0080090;GO:0019222;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:1901360;GO:1901361;GO:0051716;GO:0010608;GO:0043043;GO:0010467;GO:0060255;GO:0006446;GO:0043434;GO:0010033;GO:0046483;GO:0044700;GO:1901564;GO:1901566;GO:0019538;GO:0010243;GO:0019439;GO:0022607;GO:0070887;GO:0006807;GO:0050789;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:0071840;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034655;GO:0046700;GO:0000289;GO:0016070;GO:0016071;GO:0044271;GO:0044270;GO:0050896;GO:1901699;GO:0097010;GO:0010556;GO:0006518;GO:0070271;GO:0044248;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007154;GO:0044699;GO:0009719;GO:0006139;GO:0000288;GO:0071375;GO:0043623;GO:0051246;GO:0071495;GO:0008286;GO:0044238;GO:0009987;GO:0006725;GO:0034248;GO:0032870;GO:0043604;GO:0032268;GO:0043603;GO:0009725;GO:0043170;GO:0000956;GO:1901698;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0034622;GO:0032869;GO:0032868;GO:0071822;GO:0071417;GO:2000112;GO:0071704;GO:0071310;GO:0006401;GO:0006402;GO:0010468;GO:1901576;GO:0006461;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0042221;GO:0009056;GO:0009057;GO:1901700;GO:1901701;GO:0044237;GO:0044085;GO:1901652;GO:1901653;GO:0006417;GO:0006413;GO:0006412; regulation of primary metabolic process;regulation of metabolic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;organic cyclic compound metabolic process;organic cyclic compound catabolic process;cellular response to stimulus;posttranscriptional regulation of gene expression;peptide biosynthetic process;gene expression;regulation of macromolecule metabolic process;regulation of translational initiation;response to peptide hormone;response to organic substance;heterocycle metabolic process;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;response to organonitrogen compound;aromatic compound catabolic process;cellular component assembly;cellular response to chemical stimulus;nitrogen compound metabolic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound catabolic process;heterocycle catabolic process;nuclear-transcribed mRNA poly(A) tail shortening;RNA metabolic process;mRNA metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;response to stimulus;cellular response to nitrogen compound;eukaryotic translation initiation factor 4F complex assembly;regulation of macromolecule biosynthetic process;peptide metabolic process;protein complex biogenesis;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;single-organism process;response to endogenous stimulus;nucleobase-containing compound metabolic process;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;cellular response to peptide hormone stimulus;cellular protein complex assembly;regulation of protein metabolic process;cellular response to endogenous stimulus;insulin receptor signaling pathway;primary metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of cellular amide metabolic process;cellular response to hormone stimulus;amide biosynthetic process;regulation of cellular protein metabolic process;cellular amide metabolic process;response to hormone;macromolecule metabolic process;nuclear-transcribed mRNA catabolic process;response to nitrogen compound;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;cellular response to insulin stimulus;response to insulin;protein complex subunit organization;cellular response to organonitrogen compound;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;RNA catabolic process;mRNA catabolic process;regulation of gene expression;organic substance biosynthetic process;protein complex assembly;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;response to chemical;catabolic process;macromolecule catabolic process;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular metabolic process;cellular component biogenesis;response to peptide;cellular response to peptide;regulation of translation;translational initiation;translation; 4;3;4;5;6;7;4;5;3;6;6;5;4;5;5;4;4;3;4;5;4;4;5;4;4;3;2;5;4;5;4;3;5;2;2;4;3;1;2;5;5;9;5;6;5;5;2;5;7;5;5;4;4;4;4;2;5;4;2;3;4;9;6;6;5;4;8;3;2;4;5;5;6;5;5;4;4;8;4;4;5;4;5;6;7;6;5;5;6;3;5;6;7;5;4;5;3;5;3;4;3;3;5;4;5;3;3;5;6;6;4;6; GO:0043234;GO:0005829;GO:0005622;GO:0016281;GO:0005737;GO:0044424;GO:0044444;GO:0044464;GO:0005623;GO:0032991;GO:0005575; protein complex;cytosol;intracellular;eukaryotic translation initiation factor 4F complex;cytoplasm;intracellular part;cytoplasmic part;cell part;cell;macromolecular complex;cellular_component; 3;5;3;4;4;3;4;2;2;2;1; GO:1901363;GO:0000166;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0097159;GO:0003743;GO:0044822;GO:0003723;GO:0008135;GO:0036094; heterocyclic compound binding;nucleotide binding;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;organic cyclic compound binding;translation initiation factor activity;poly(A) RNA binding;RNA binding;translation factor activity, RNA binding;small molecule binding; 3;4;1;2;4;4;3;7;6;5;6;3; K03258 map03013;map04150;map04151;map05205; RNA transport;mTOR signaling pathway;PI3K-Akt signaling pathway;Proteoglycans in cancer; IPR000504;IPR033107; RNA recognition motif domain;Eukaryotic translation initiation factor 4B; nucleus Hs4503533 1201.0 R [R] General function prediction only; P98171 Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2 - [RHG04_HUMAN] 1.001 1.105 0.85 1.096 1.168 1.089 0.905882353 nan 0.938356164 nan 0.769230769 nan 0.932363014 nan GO:0061387;GO:0048675;GO:0048589;GO:0048588;GO:0001667;GO:0048584;GO:0007266;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0031345;GO:0031344;GO:0071840;GO:0051716;GO:0009966;GO:0009967;GO:0070848;GO:0045665;GO:0045664;GO:0010721;GO:0048518;GO:0048519;GO:0051056;GO:0038179;GO:1990138;GO:0048583;GO:0008361;GO:0010977;GO:0051129;GO:0010975;GO:0030517;GO:0050771;GO:0010033;GO:0044700;GO:0016477;GO:0044707;GO:0048870;GO:0007154;GO:0032535;GO:0022604;GO:0022603;GO:0006928;GO:0031175;GO:0035556;GO:0009653;GO:0016049;GO:0000902;GO:0016043;GO:0090066;GO:0065007;GO:0048640;GO:0065008;GO:0043067;GO:0061564;GO:0050793;GO:0048468;GO:0050794;GO:0012501;GO:0008150;GO:0051239;GO:0048011;GO:0050896;GO:0048812;GO:2000145;GO:0048869;GO:0051961;GO:0048638;GO:0030308;GO:0030154;GO:0051128;GO:0023056;GO:0023052;GO:0060284;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0007265;GO:0044699;GO:0050767;GO:1902531;GO:0051241;GO:0050768;GO:0010769;GO:0010762;GO:0060560;GO:0010764;GO:0032502;GO:0040011;GO:0032501;GO:2000146;GO:0009987;GO:0051271;GO:0045596;GO:0045595;GO:0001558;GO:0007409;GO:0032879;GO:0048858;GO:0051093;GO:0010761;GO:0071363;GO:0050770;GO:0030516;GO:0051674;GO:0010771;GO:0048731;GO:0045926;GO:0030030;GO:0097190;GO:0040013;GO:0030336;GO:0010942;GO:0008219;GO:0010941;GO:0007275;GO:0040007;GO:0042981;GO:0040008;GO:0050789;GO:0043065;GO:0071310;GO:0051960;GO:0040012;GO:0043068;GO:0048666;GO:0048667;GO:0030182;GO:0006915;GO:0030334;GO:0044767;GO:0000904;GO:0044763;GO:0042221;GO:0022008;GO:0007264;GO:0051179;GO:0006996;GO:0048699;GO:0051270;GO:0007010;GO:0032990;GO:0007399;GO:0048856;GO:2000026;GO:0032989;GO:0048523;GO:0048522; regulation of extent of cell growth;axon extension;developmental growth;developmental cell growth;ameboidal-type cell migration;positive regulation of response to stimulus;Rho protein signal transduction;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;cellular response to stimulus;regulation of signal transduction;positive regulation of signal transduction;response to growth factor;negative regulation of neuron differentiation;regulation of neuron differentiation;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of small GTPase mediated signal transduction;neurotrophin signaling pathway;neuron projection extension;regulation of response to stimulus;regulation of cell size;negative regulation of neuron projection development;negative regulation of cellular component organization;regulation of neuron projection development;negative regulation of axon extension;negative regulation of axonogenesis;response to organic substance;single organism signaling;cell migration;single-multicellular organism process;cell motility;cell communication;regulation of cellular component size;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;neuron projection development;intracellular signal transduction;anatomical structure morphogenesis;cell growth;cell morphogenesis;cellular component organization;regulation of anatomical structure size;biological regulation;negative regulation of developmental growth;regulation of biological quality;regulation of programmed cell death;axon development;regulation of developmental process;cell development;regulation of cellular process;programmed cell death;biological_process;regulation of multicellular organismal process;neurotrophin TRK receptor signaling pathway;response to stimulus;neuron projection morphogenesis;regulation of cell motility;cellular developmental process;negative regulation of nervous system development;regulation of developmental growth;negative regulation of cell growth;cell differentiation;regulation of cellular component organization;positive regulation of signaling;signaling;regulation of cell development;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;Ras protein signal transduction;single-organism process;regulation of neurogenesis;regulation of intracellular signal transduction;negative regulation of multicellular organismal process;negative regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of fibroblast migration;developmental growth involved in morphogenesis;negative regulation of fibroblast migration;developmental process;locomotion;multicellular organismal process;negative regulation of cell motility;cellular process;negative regulation of cellular component movement;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cell growth;axonogenesis;regulation of localization;cell projection morphogenesis;negative regulation of developmental process;fibroblast migration;cellular response to growth factor stimulus;regulation of axonogenesis;regulation of axon extension;localization of cell;negative regulation of cell morphogenesis involved in differentiation;system development;negative regulation of growth;cell projection organization;apoptotic signaling pathway;negative regulation of locomotion;negative regulation of cell migration;positive regulation of cell death;cell death;regulation of cell death;multicellular organism development;growth;regulation of apoptotic process;regulation of growth;regulation of biological process;positive regulation of apoptotic process;cellular response to organic substance;regulation of nervous system development;regulation of locomotion;positive regulation of programmed cell death;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;apoptotic process;regulation of cell migration;single-organism developmental process;cell morphogenesis involved in differentiation;single-organism cellular process;response to chemical;neurogenesis;small GTPase mediated signal transduction;localization;organelle organization;generation of neurons;regulation of cellular component movement;cytoskeleton organization;cell part morphogenesis;nervous system development;anatomical structure development;regulation of multicellular organismal development;cellular component morphogenesis;negative regulation of cellular process;positive regulation of cellular process; 5;6;3;4;5;3;8;4;5;6;7;5;5;2;3;4;4;5;6;7;5;2;2;6;6;5;3;5;6;4;6;5;6;4;3;4;3;3;4;4;5;4;4;5;5;3;3;5;3;4;2;4;3;5;6;3;4;3;5;1;3;7;2;6;4;4;4;4;4;5;4;3;2;5;4;3;4;4;7;2;6;5;3;5;6;6;4;6;2;2;2;4;2;4;4;4;4;7;3;5;3;6;6;7;5;3;5;4;3;4;5;3;5;4;4;4;4;2;6;3;2;6;5;5;3;5;5;6;6;6;5;3;5;3;3;6;6;2;4;7;4;5;5;5;3;4;4;3;3; GO:0099512;GO:0099513;GO:0030427;GO:0030426;GO:0042995;GO:0043231;GO:0005829;GO:0044424;GO:0043232;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0012505;GO:0044446;GO:0044422;GO:0005874;GO:0005737;GO:0043005;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0005794;GO:0044444;GO:0097458;GO:0015630;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;site of polarized growth;growth cone;cell projection;intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;endomembrane system;intracellular organelle part;organelle part;microtubule;cytoplasm;neuron projection;cell projection part;cell part;cell;intracellular;Golgi apparatus;cytoplasmic part;neuron part;microtubule cytoskeleton;cellular_component; 2;3;3;4;3;4;5;3;4;3;3;3;2;5;4;3;3;2;4;4;4;3;2;2;3;4;4;3;6;1; GO:0031267;GO:0098772;GO:0005070;GO:0005096;GO:0030695;GO:0060090;GO:0003674;GO:0005488;GO:0017016;GO:0030674;GO:0048365;GO:0019899;GO:0060589;GO:0051020;GO:0005515;GO:0017048;GO:0008047;GO:0030234;GO:0035591; small GTPase binding;molecular function regulator;SH3/SH2 adaptor activity;GTPase activator activity;GTPase regulator activity;binding, bridging;molecular_function;binding;Ras GTPase binding;protein binding, bridging;Rac GTPase binding;enzyme binding;nucleoside-triphosphatase regulator activity;GTPase binding;protein binding;Rho GTPase binding;enzyme activator activity;enzyme regulator activity;signaling adaptor activity; 6;2;5;5;5;3;1;2;7;4;9;4;4;5;3;8;4;3;4; K20122 IPR031160;IPR027267;IPR000198;IPR001452;IPR008936;IPR001060;IPR035678; F-BAR domain;Arfaptin homology (AH) domain/BAR domain;Rho GTPase-activating protein domain;SH3 domain;Rho GTPase activation protein;FCH domain;srGAP4, SH3 domain; nucleus Hs11386133 1929.0 Z [Z] Cytoskeleton; P98170 E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2 - [XIAP_HUMAN] 0.998 1.416 0.583 0.911 1.287 0.836 0.70480226 0.000528086 0.707847708 0.001146796 0.411723164 6.70E-06 0.64957265 8.10E-05 GO:0070848;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0031349;GO:0055070;GO:0030111;GO:0007165;GO:0007166;GO:0055076;GO:0098771;GO:1901576;GO:0030510;GO:1901362;GO:0031347;GO:0032774;GO:0051716;GO:0010605;GO:0010604;GO:0009966;GO:0009967;GO:0070647;GO:0050727;GO:0032446;GO:0010466;GO:0044092;GO:0048518;GO:0048519;GO:0042127;GO:0010556;GO:0060255;GO:0060548;GO:0007178;GO:0097039;GO:0042221;GO:0050776;GO:0030162;GO:2001141;GO:0010033;GO:0010467;GO:0044700;GO:0009605;GO:0019538;GO:0016055;GO:0070423;GO:0019219;GO:0048878;GO:0002376;GO:0016567;GO:0033554;GO:0019438;GO:0060828;GO:0045087;GO:0006351;GO:0070424;GO:0009892;GO:0009893;GO:0090263;GO:0007167;GO:0050778;GO:0035872;GO:0030177;GO:0035556;GO:0050789;GO:0097659;GO:0044267;GO:0051346;GO:0046483;GO:0000209;GO:0070887;GO:0065007;GO:1901360;GO:0006366;GO:0065009;GO:0065008;GO:0018130;GO:0016485;GO:1902914;GO:0006139;GO:0050790;GO:0009889;GO:0090287;GO:0050794;GO:0006952;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:1902530;GO:1902531;GO:0051336;GO:0070613;GO:0044271;GO:0051604;GO:0060070;GO:0050896;GO:0031401;GO:0002758;GO:0006950;GO:0043154;GO:0006357;GO:0002753;GO:1903317;GO:0071772;GO:0071773;GO:0009719;GO:0006954;GO:0032101;GO:0010629;GO:0050801;GO:0071310;GO:0030509;GO:0009611;GO:0023056;GO:1990001;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043086;GO:0044699;GO:0051248;GO:0051246;GO:0051247;GO:1902916;GO:1903320;GO:1903322;GO:0032270;GO:0031398;GO:0031399;GO:0031396;GO:0006508;GO:1903034;GO:0002221;GO:0071495;GO:0016070;GO:0008283;GO:0031323;GO:0009987;GO:0006725;GO:1903506;GO:0006974;GO:0043281;GO:0002757;GO:0055080;GO:0090304;GO:0032269;GO:0032268;GO:0071363;GO:0002684;GO:0051252;GO:0043170;GO:0006807;GO:0045861;GO:1902528;GO:0080134;GO:0031326;GO:0031325;GO:0031324;GO:0097190;GO:0097193;GO:0042592;GO:0008219;GO:0010941;GO:0002682;GO:0030522;GO:0006355;GO:2000116;GO:0042981;GO:0012501;GO:2000112;GO:0071704;GO:0043067;GO:0043066;GO:0002218;GO:0043069;GO:0010468;GO:1903318;GO:0090092;GO:0045089;GO:0045088;GO:0052547;GO:0052548;GO:0006915;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0055065;GO:0010951;GO:0007154;GO:0010955;GO:0002764;GO:0044238;GO:0044260;GO:0044237;GO:0097341;GO:0097340;GO:0002253;GO:2000117;GO:0044249;GO:0048523;GO:0048522; response to growth factor;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;copper ion homeostasis;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;transition metal ion homeostasis;inorganic ion homeostasis;organic substance biosynthetic process;regulation of BMP signaling pathway;organic cyclic compound biosynthetic process;regulation of defense response;RNA biosynthetic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;protein modification by small protein conjugation or removal;regulation of inflammatory response;protein modification by small protein conjugation;negative regulation of peptidase activity;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;regulation of macromolecule biosynthetic process;regulation of macromolecule metabolic process;negative regulation of cell death;transmembrane receptor protein serine/threonine kinase signaling pathway;protein linear polyubiquitination;response to chemical;regulation of immune response;regulation of proteolysis;regulation of RNA biosynthetic process;response to organic substance;gene expression;single organism signaling;response to external stimulus;protein metabolic process;Wnt signaling pathway;nucleotide-binding oligomerization domain containing signaling pathway;regulation of nucleobase-containing compound metabolic process;chemical homeostasis;immune system process;protein ubiquitination;cellular response to stress;aromatic compound biosynthetic process;regulation of canonical Wnt signaling pathway;innate immune response;transcription, DNA-templated;regulation of nucleotide-binding oligomerization domain containing signaling pathway;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of canonical Wnt signaling pathway;enzyme linked receptor protein signaling pathway;positive regulation of immune response;nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;positive regulation of Wnt signaling pathway;intracellular signal transduction;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;negative regulation of hydrolase activity;heterocycle metabolic process;protein polyubiquitination;cellular response to chemical stimulus;biological regulation;organic cyclic compound metabolic process;transcription from RNA polymerase II promoter;regulation of molecular function;regulation of biological quality;heterocycle biosynthetic process;protein processing;regulation of protein polyubiquitination;nucleobase-containing compound metabolic process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular response to growth factor stimulus;regulation of cellular process;defense response;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;positive regulation of protein linear polyubiquitination;regulation of intracellular signal transduction;regulation of hydrolase activity;regulation of protein processing;cellular nitrogen compound biosynthetic process;protein maturation;canonical Wnt signaling pathway;response to stimulus;positive regulation of protein modification process;innate immune response-activating signal transduction;response to stress;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of transcription from RNA polymerase II promoter;cytoplasmic pattern recognition receptor signaling pathway;regulation of protein maturation;response to BMP;cellular response to BMP stimulus;response to endogenous stimulus;inflammatory response;regulation of response to external stimulus;negative regulation of gene expression;ion homeostasis;cellular response to organic substance;BMP signaling pathway;response to wounding;positive regulation of signaling;inhibition of cysteine-type endopeptidase activity involved in apoptotic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of protein polyubiquitination;regulation of protein modification by small protein conjugation or removal;positive regulation of protein modification by small protein conjugation or removal;positive regulation of cellular protein metabolic process;positive regulation of protein ubiquitination;regulation of protein modification process;regulation of protein ubiquitination;proteolysis;regulation of response to wounding;pattern recognition receptor signaling pathway;cellular response to endogenous stimulus;RNA metabolic process;cell proliferation;regulation of cellular metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;regulation of cysteine-type endopeptidase activity involved in apoptotic process;immune response-activating signal transduction;cation homeostasis;nucleic acid metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;positive regulation of immune system process;regulation of RNA metabolic process;macromolecule metabolic process;nitrogen compound metabolic process;negative regulation of proteolysis;regulation of protein linear polyubiquitination;regulation of response to stress;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;homeostatic process;cell death;regulation of cell death;regulation of immune system process;intracellular receptor signaling pathway;regulation of transcription, DNA-templated;regulation of cysteine-type endopeptidase activity;regulation of apoptotic process;programmed cell death;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;activation of innate immune response;negative regulation of programmed cell death;regulation of gene expression;negative regulation of protein maturation;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;positive regulation of innate immune response;regulation of innate immune response;regulation of peptidase activity;regulation of endopeptidase activity;apoptotic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;metal ion homeostasis;negative regulation of endopeptidase activity;cell communication;negative regulation of protein processing;immune response-regulating signaling pathway;primary metabolic process;cellular macromolecule metabolic process;cellular metabolic process;zymogen inhibition;inhibition of cysteine-type endopeptidase activity;activation of immune response;negative regulation of cysteine-type endopeptidase activity;cellular biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 5;4;3;3;3;4;10;5;4;5;9;7;4;5;5;5;6;3;4;4;4;4;7;5;8;7;4;2;2;4;5;4;4;7;11;3;4;6;6;4;5;3;3;4;6;7;5;5;2;9;4;5;6;4;6;6;3;3;6;6;4;6;5;5;2;7;5;6;4;10;4;2;4;7;3;3;5;6;9;4;4;4;4;3;4;5;5;1;2;3;5;10;5;5;7;5;5;7;2;6;5;3;7;7;6;6;4;5;3;5;4;5;6;5;6;4;3;8;4;2;5;3;4;4;5;2;5;5;5;9;7;7;5;8;6;8;5;5;6;4;5;3;4;2;4;7;5;7;4;7;5;5;5;6;3;5;4;3;6;10;4;5;4;4;5;6;4;4;4;3;5;6;8;6;5;6;3;5;6;4;5;5;6;5;5;5;6;7;6;6;3;5;3;4;8;8;4;7;5;3;4;3;8;9;3;9;4;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0044444;GO:0044422;GO:0005737;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;organelle part;cytoplasm;nucleus;cell part;intracellular organelle;cell;organelle;cellular_component;intracellular organelle lumen; 2;5;4;3;5;4;3;3;3;5;3;4;2;4;5;2;3;2;2;1;4; GO:0098772;GO:0016740;GO:0046872;GO:0016874;GO:0008270;GO:0004857;GO:0003674;GO:0005488;GO:0046914;GO:0061659;GO:0043028;GO:0061135;GO:0043027;GO:0019787;GO:0061134;GO:0003824;GO:0004842;GO:0043169;GO:0061630;GO:0043167;GO:0030414;GO:0004866;GO:0004869;GO:0030234; molecular function regulator;transferase activity;metal ion binding;ligase activity;zinc ion binding;enzyme inhibitor activity;molecular_function;binding;transition metal ion binding;ubiquitin-like protein ligase activity;cysteine-type endopeptidase regulator activity involved in apoptotic process;endopeptidase regulator activity;cysteine-type endopeptidase inhibitor activity involved in apoptotic process;ubiquitin-like protein transferase activity;peptidase regulator activity;catalytic activity;ubiquitin-protein transferase activity;cation binding;ubiquitin protein ligase activity;ion binding;peptidase inhibitor activity;endopeptidase inhibitor activity;cysteine-type endopeptidase inhibitor activity;enzyme regulator activity; 2;3;5;3;7;4;1;2;6;5;4;5;5;4;4;2;5;4;6;3;5;6;7;3; K04725 map04064;map04120;map04210;map04214;map04215;map04510;map05145;map05166;map05200;map05222; NF-kappa B signaling pathway;Ubiquitin mediated proteolysis;Apoptosis;Apoptosis - fly;Apoptosis - multiple species;Focal adhesion;Toxoplasmosis;HTLV-I infection;Pathways in cancer;Small cell lung cancer; IPR001370;IPR001841; BIR repeat;Zinc finger, RING-type; cytosol Hs4502143 1047.0 DR [D] Cell cycle control, cell division, chromosome partitioning;[R] General function prediction only; Q8WWN8 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARAP3 PE=1 SV=1 - [ARAP3_HUMAN] 1.191 1.386 0.501 1.226 1.164 0.472 0.859307359 0.384174806 1.053264605 0.254723499 0.361471861 0.040593258 0.405498282 0.042008411 GO:0048585;GO:0048583;GO:0007266;GO:0007165;GO:0071840;GO:0051716;GO:0009968;GO:0009966;GO:0048869;GO:0048519;GO:0051056;GO:0051058;GO:0008360;GO:0044700;GO:0016477;GO:0016192;GO:0048870;GO:0035020;GO:0035021;GO:0022604;GO:0022603;GO:0035023;GO:0006928;GO:0051271;GO:0035556;GO:0010646;GO:0000902;GO:0016601;GO:0016043;GO:0065007;GO:0065008;GO:0050793;GO:0006810;GO:0050794;GO:0008150;GO:1902532;GO:1902531;GO:0050896;GO:2000145;GO:2000146;GO:0046578;GO:0051128;GO:0035024;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0009653;GO:0044699;GO:0051234;GO:0032502;GO:0006996;GO:0009987;GO:0051270;GO:0032879;GO:0051674;GO:0050789;GO:0030336;GO:0030334;GO:0044767;GO:0044763;GO:0046580;GO:0007154;GO:0007265;GO:0007264;GO:0051179;GO:0040011;GO:0040013;GO:0040012;GO:0007010;GO:0048856;GO:0032989;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;Rho protein signal transduction;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;negative regulation of biological process;regulation of small GTPase mediated signal transduction;negative regulation of small GTPase mediated signal transduction;regulation of cell shape;single organism signaling;cell migration;vesicle-mediated transport;cell motility;regulation of Rac protein signal transduction;negative regulation of Rac protein signal transduction;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;regulation of Rho protein signal transduction;movement of cell or subcellular component;negative regulation of cellular component movement;intracellular signal transduction;regulation of cell communication;cell morphogenesis;Rac protein signal transduction;cellular component organization;biological regulation;regulation of biological quality;regulation of developmental process;transport;regulation of cellular process;biological_process;negative regulation of intracellular signal transduction;regulation of intracellular signal transduction;response to stimulus;regulation of cell motility;negative regulation of cell motility;regulation of Ras protein signal transduction;regulation of cellular component organization;negative regulation of Rho protein signal transduction;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;anatomical structure morphogenesis;single-organism process;establishment of localization;developmental process;organelle organization;cellular process;regulation of cellular component movement;regulation of localization;localization of cell;regulation of biological process;negative regulation of cell migration;regulation of cell migration;single-organism developmental process;single-organism cellular process;negative regulation of Ras protein signal transduction;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;localization;locomotion;negative regulation of locomotion;regulation of locomotion;cytoskeleton organization;anatomical structure development;cellular component morphogenesis;negative regulation of cellular process; 3;3;8;4;2;3;4;4;4;2;6;6;4;3;4;5;3;8;8;5;4;8;4;4;5;4;5;8;3;2;3;3;4;3;1;5;5;2;4;4;7;4;8;3;2;4;3;3;2;3;2;4;2;4;3;3;2;5;5;3;3;7;4;7;6;2;2;3;3;5;3;4;3; GO:0042995;GO:0043232;GO:0005829;GO:0044424;GO:0043229;GO:0043228;GO:0043226;GO:0005856;GO:0031252;GO:0044444;GO:0016020;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0001726;GO:0030027;GO:0005886;GO:0005575; cell projection;intracellular non-membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;non-membrane-bounded organelle;organelle;cytoskeleton;cell leading edge;cytoplasmic part;membrane;cytoplasm;cell part;cell;intracellular;cell periphery;ruffle;lamellipodium;plasma membrane;cellular_component; 3;4;5;3;3;3;2;5;3;4;2;4;2;2;3;3;4;4;3;1; GO:0098772;GO:0005543;GO:0005547;GO:0043325;GO:0046872;GO:0005096;GO:0030695;GO:0003674;GO:0005488;GO:1902936;GO:0043168;GO:1901981;GO:0035091;GO:0043169;GO:0043167;GO:0008289;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;phospholipid binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;metal ion binding;GTPase activator activity;GTPase regulator activity;molecular_function;binding;phosphatidylinositol bisphosphate binding;anion binding;phosphatidylinositol phosphate binding;phosphatidylinositol binding;cation binding;ion binding;lipid binding;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;4;7;8;5;5;5;1;2;7;4;6;5;4;3;3;4;4;3; K12490 map04015;map04024;map04144; Rap1 signaling pathway;cAMP signaling pathway;Endocytosis; IPR001164;IPR029071;IPR000159;IPR013761;IPR000198;IPR008936;IPR001849;IPR001660;IPR011993; Arf GTPase activating protein;Ubiquitin-related domain;Ras-associating (RA) domain;Sterile alpha motif/pointed domain;Rho GTPase-activating protein domain;Rho GTPase activation protein;Pleckstrin homology domain;Sterile alpha motif domain;PH domain-like; cytosol Hs21264337_1 2751.0 TZ [T] Signal transduction mechanisms;[Z] Cytoskeleton; A0A0C4DH32 Immunoglobulin heavy variable 3-20 OS=Homo sapiens OX=9606 GN=IGHV3-20 PE=3 SV=2 - [HV320_HUMAN] 0.962 1.149 0.783 0.873 1.056 2.261 0.837249782 0.376810946 0.826704545 0.410587993 0.681462141 0.167181797 2.141098485 0.094471004 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P06733 Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2 - [ENOA_HUMAN] 1.226 1.112 0.768 1.211 0.982 1.151 1.102517986 0.062459293 1.233197556 0.002088257 0.690647482 0.000736977 1.17209776 0.39430711 GO:0080090;GO:0019222;GO:0051098;GO:0009167;GO:0061621;GO:0061620;GO:0044281;GO:0044282;GO:0009161;GO:1901362;GO:0071840;GO:0044712;GO:0044710;GO:0044711;GO:0010605;GO:0043207;GO:0009615;GO:0009199;GO:0044093;GO:0006733;GO:0048519;GO:0009205;GO:0060255;GO:0046034;GO:0006366;GO:0046031;GO:0032787;GO:2001141;GO:0043436;GO:0046128;GO:0009179;GO:0051253;GO:0055114;GO:0046483;GO:0006735;GO:1901564;GO:0009605;GO:0044249;GO:0016052;GO:0016051;GO:0006163;GO:0006165;GO:0019637;GO:0019320;GO:0044707;GO:0009892;GO:0009890;GO:0009141;GO:0044283;GO:0009144;GO:0061718;GO:0006807;GO:0046496;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:1901575;GO:0051186;GO:0016049;GO:0044260;GO:0016043;GO:0065007;GO:1901360;GO:0065009;GO:0018130;GO:0009889;GO:0019318;GO:0019319;GO:0009150;GO:0051128;GO:0008150;GO:0008152;GO:0019438;GO:0044723;GO:0050794;GO:0044724;GO:0016070;GO:0044767;GO:0044271;GO:0050896;GO:0006355;GO:0006357;GO:0006351;GO:0007275;GO:0009117;GO:0006753;GO:0010558;GO:0006757;GO:0032774;GO:0030308;GO:0019674;GO:0006732;GO:0016310;GO:0006734;GO:0034641;GO:0009792;GO:0034645;GO:0009123;GO:0009126;GO:0009259;GO:0044699;GO:0006139;GO:0001701;GO:0000122;GO:0042278;GO:0046939;GO:0031327;GO:0031326;GO:0043009;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0001558;GO:0045892;GO:0009132;GO:0009135;GO:0055086;GO:0061615;GO:0051707;GO:0006082;GO:0005996;GO:1901135;GO:0051252;GO:0010629;GO:0009607;GO:0006006;GO:0006007;GO:0009790;GO:0009185;GO:0045926;GO:0046365;GO:0046364;GO:0031324;GO:0031323;GO:0019752;GO:0090304;GO:0019693;GO:0072521;GO:0006091;GO:0006090;GO:0072524;GO:0006096;GO:0006094;GO:0040007;GO:0051171;GO:0040008;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0010556;GO:0051704;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0009116;GO:0051172;GO:0009119;GO:0009056;GO:0044238;GO:0005975;GO:0048856;GO:0051099;GO:0044237;GO:1901657;GO:0006796;GO:0006793;GO:0034654;GO:0048523;GO:0019362; regulation of primary metabolic process;regulation of metabolic process;regulation of binding;purine ribonucleoside monophosphate metabolic process;canonical glycolysis;glycolytic process through glucose-6-phosphate;small molecule metabolic process;small molecule catabolic process;ribonucleoside monophosphate metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;negative regulation of macromolecule metabolic process;response to external biotic stimulus;response to virus;ribonucleoside triphosphate metabolic process;positive regulation of molecular function;oxidoreduction coenzyme metabolic process;negative regulation of biological process;purine ribonucleoside triphosphate metabolic process;regulation of macromolecule metabolic process;ATP metabolic process;transcription from RNA polymerase II promoter;ADP metabolic process;monocarboxylic acid metabolic process;regulation of RNA biosynthetic process;oxoacid metabolic process;purine ribonucleoside metabolic process;purine ribonucleoside diphosphate metabolic process;negative regulation of RNA metabolic process;oxidation-reduction process;heterocycle metabolic process;NADH regeneration;organonitrogen compound metabolic process;response to external stimulus;cellular biosynthetic process;carbohydrate catabolic process;carbohydrate biosynthetic process;purine nucleotide metabolic process;nucleoside diphosphate phosphorylation;organophosphate metabolic process;hexose catabolic process;single-multicellular organism process;negative regulation of metabolic process;negative regulation of biosynthetic process;nucleoside triphosphate metabolic process;small molecule biosynthetic process;purine nucleoside triphosphate metabolic process;glucose catabolic process to pyruvate;nitrogen compound metabolic process;nicotinamide nucleotide metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;organic substance catabolic process;cofactor metabolic process;cell growth;cellular macromolecule metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;regulation of molecular function;heterocycle biosynthetic process;regulation of biosynthetic process;hexose metabolic process;hexose biosynthetic process;purine ribonucleotide metabolic process;regulation of cellular component organization;biological_process;metabolic process;aromatic compound biosynthetic process;single-organism carbohydrate metabolic process;regulation of cellular process;single-organism carbohydrate catabolic process;RNA metabolic process;single-organism developmental process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;multicellular organism development;nucleotide metabolic process;nucleoside phosphate metabolic process;negative regulation of macromolecule biosynthetic process;ATP generation from ADP;RNA biosynthetic process;negative regulation of cell growth;NAD metabolic process;coenzyme metabolic process;phosphorylation;NADH metabolic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;cellular macromolecule biosynthetic process;nucleoside monophosphate metabolic process;purine nucleoside monophosphate metabolic process;ribonucleotide metabolic process;single-organism process;nucleobase-containing compound metabolic process;in utero embryonic development;negative regulation of transcription from RNA polymerase II promoter;purine nucleoside metabolic process;nucleotide phosphorylation;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;chordate embryonic development;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;regulation of cell growth;negative regulation of transcription, DNA-templated;nucleoside diphosphate metabolic process;purine nucleoside diphosphate metabolic process;nucleobase-containing small molecule metabolic process;glycolytic process through fructose-6-phosphate;response to other organism;organic acid metabolic process;monosaccharide metabolic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;response to biotic stimulus;glucose metabolic process;glucose catabolic process;embryo development;ribonucleoside diphosphate metabolic process;negative regulation of growth;monosaccharide catabolic process;monosaccharide biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;nucleic acid metabolic process;ribose phosphate metabolic process;purine-containing compound metabolic process;generation of precursor metabolites and energy;pyruvate metabolic process;pyridine-containing compound metabolic process;glycolytic process;gluconeogenesis;growth;regulation of nitrogen compound metabolic process;regulation of growth;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;multi-organism process;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;nucleoside metabolic process;negative regulation of nitrogen compound metabolic process;ribonucleoside metabolic process;catabolic process;primary metabolic process;carbohydrate metabolic process;anatomical structure development;positive regulation of binding;cellular metabolic process;glycosyl compound metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;nucleobase-containing compound biosynthetic process;negative regulation of cellular process;pyridine nucleotide metabolic process; 4;3;4;8;6;8;4;5;7;5;2;4;3;4;4;4;4;7;4;6;2;8;4;8;7;8;7;6;5;7;8;5;4;4;5;4;3;4;5;5;6;7;4;7;3;3;4;6;5;7;9;3;7;4;2;7;4;4;4;3;4;3;2;4;3;5;4;6;7;7;4;1;2;5;4;3;5;5;3;5;2;6;7;6;4;6;5;5;5;6;4;8;5;6;9;4;6;5;6;7;6;2;4;8;7;6;7;5;5;7;2;2;2;4;7;7;4;6;6;7;4;7;3;4;5;4;5;5;3;7;8;5;7;3;6;6;4;4;6;5;5;5;4;8;5;6;8;2;4;3;6;6;3;5;5;2;5;5;5;6;3;5;3;5;4;6;3;3;4;3;5;3;4;5;4;5;3;6; GO:0031982;GO:0044445;GO:0043209;GO:0016020;GO:0000015;GO:1902494;GO:0043230;GO:0043232;GO:0005829;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0031672;GO:0044424;GO:0044444;GO:0019897;GO:0019898;GO:0030016;GO:0030017;GO:0005737;GO:0043231;GO:0005634;GO:0005615;GO:0044459;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0071944;GO:0031430;GO:0043226;GO:0005886;GO:0043234;GO:1903561;GO:0070062;GO:0005575;GO:0005576;GO:0043292;GO:0044449; vesicle;cytosolic part;myelin sheath;membrane;phosphopyruvate hydratase complex;catalytic complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;membrane part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;A band;intracellular part;cytoplasmic part;extrinsic component of plasma membrane;extrinsic component of membrane;myofibril;sarcomere;cytoplasm;intracellular membrane-bounded organelle;nucleus;extracellular space;plasma membrane part;macromolecular complex;cell part;cell;intracellular;non-membrane-bounded organelle;cell periphery;M band;organelle;plasma membrane;protein complex;extracellular vesicle;extracellular exosome;cellular_component;extracellular region;contractile fiber;contractile fiber part; 4;5;3;2;5;4;3;4;5;2;2;2;3;3;4;3;4;4;3;6;4;4;4;5;3;3;2;2;2;3;3;3;4;2;3;3;3;4;1;2;5;3; GO:1901363;GO:0003712;GO:0046872;GO:0019899;GO:0001071;GO:0003674;GO:0003676;GO:0003677;GO:0000989;GO:0000988;GO:0004634;GO:0043169;GO:0016829;GO:0003824;GO:0097159;GO:0051020;GO:0003714;GO:0043167;GO:0044822;GO:0003723;GO:0005515;GO:0016835;GO:0016836;GO:0000287;GO:0005488;GO:0003700; heterocyclic compound binding;transcription cofactor activity;metal ion binding;enzyme binding;nucleic acid binding transcription factor activity;molecular_function;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;phosphopyruvate hydratase activity;cation binding;lyase activity;catalytic activity;organic cyclic compound binding;GTPase binding;transcription corepressor activity;ion binding;poly(A) RNA binding;RNA binding;protein binding;carbon-oxygen lyase activity;hydro-lyase activity;magnesium ion binding;binding;transcription factor activity, sequence-specific DNA binding; 3;4;5;4;2;1;4;5;3;2;6;4;3;2;3;5;5;3;6;5;3;4;5;6;2;3; K01689 map00010;map00680;map01100;map01110;map01120;map01130;map01200;map01230;map03018;map04066; Glycolysis / Gluconeogenesis;Methane metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids;RNA degradation;HIF-1 signaling pathway; IPR029065;IPR020809;IPR000941;IPR029017;IPR034390;IPR020811;IPR020810; Enolase C-terminal domain-like;Enolase, conserved site;Enolase;Enolase N-terminal domain-like;Enolase-like superfamily;Enolase, N-terminal;Enolase, C-terminal TIM barrel domain; cytosol Hs4503571 893.0 G [G] Carbohydrate transport and metabolism; A0A0J9YX35 Immunoglobulin heavy variable 3-64D OS=Homo sapiens OX=9606 GN=IGHV3-64D PE=3 SV=1 - [HV64D_HUMAN] 1.029 1.042 0.928 1.009 1.072 1.063 0.987523992 0.774969327 0.941231343 0.73227538 0.89059501 0.704403402 0.991604478 0.767492444 IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular A0A0C4DH31 Immunoglobulin heavy variable 1-18 OS=Homo sapiens OX=9606 GN=IGHV1-18 PE=3 SV=1 - [HV118_HUMAN] 1.002 1.024 1.003 0.989 1.033 1.182 0.978515625 0.879745231 0.957405615 0.294571345 0.979492188 0.795181519 1.144240077 0.080085558 IPR013106;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular A0A0C4DH34 Immunoglobulin heavy variable 4-28 OS=Homo sapiens OX=9606 GN=IGHV4-28 PE=3 SV=1 - [HV428_HUMAN] 0.914 0.933 1.325 0.853 0.964 0.843 0.979635584 0.763411579 0.884854772 0.044896595 1.420150054 1.33E-06 0.874481328 0.263138045 K06856 map04020;map04064;map04072;map04145;map04151;map04640;map04650;map04662;map04664;map04666;map04672;map05140;map05143;map05146;map05150;map05152;map05162;map05169;map05202;map05310;map05320;map05322;map05323;map05330;map05340;map05414;map05416; Calcium signaling pathway;NF-kappa B signaling pathway;Phospholipase D signaling pathway;Phagosome;PI3K-Akt signaling pathway;Hematopoietic cell lineage;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Intestinal immune network for IgA production;Leishmaniasis;African trypanosomiasis;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;Measles;Epstein-Barr virus infection;Transcriptional misregulation in cancer;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Primary immunodeficiency;Dilated cardiomyopathy;Viral myocarditis; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular A0A0C4DH38 Immunoglobulin heavy variable 5-51 OS=Homo sapiens OX=9606 GN=IGHV5-51 PE=3 SV=1 - [HV551_HUMAN] 1.014 1.108 0.934 1.099 1.117 0.959 0.915162455 0.13254542 0.983885407 0.13588513 0.842960289 0.208760814 0.858549687 0.741780147 IPR013106;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular Q06945 Transcription factor SOX-4 OS=Homo sapiens OX=9606 GN=SOX4 PE=1 SV=1 - [SOX4_HUMAN] 1.12 1.288 0.62 1.137 1.195 0.843 0.869565217 0.0047282 0.951464435 0.029275214 0.48136646 4.04E-07 0.705439331 0.000143676 GO:0033157;GO:0051169;GO:0051168;GO:0051046;GO:0051047;GO:0051049;GO:0001501;GO:0051716;GO:0072422;GO:0030855;GO:0006473;GO:0032387;GO:0048583;GO:0006474;GO:0035270;GO:0046483;GO:0071593;GO:0034284;GO:0019538;GO:0030111;GO:0009892;GO:0009893;GO:0009891;GO:0090263;GO:0051254;GO:0030177;GO:0051222;GO:0051223;GO:0072331;GO:0050789;GO:0030072;GO:0030073;GO:0003205;GO:0003207;GO:0003206;GO:0006886;GO:0003209;GO:0003208;GO:0018130;GO:0070201;GO:0098602;GO:1903649;GO:0098609;GO:0009888;GO:0007050;GO:0043412;GO:0002521;GO:0002520;GO:0016070;GO:0050714;GO:0010557;GO:0010556;GO:0035905;GO:0035904;GO:0035909;GO:0034250;GO:1903827;GO:0035019;GO:1901991;GO:1901990;GO:0010001;GO:0044819;GO:1903828;GO:1901988;GO:0008284;GO:0008285;GO:0035239;GO:0008283;GO:0006974;GO:0046883;GO:0001655;GO:0046887;GO:0060341;GO:0042592;GO:0042593;GO:0022402;GO:0008219;GO:0007275;GO:2000112;GO:0043065;GO:0043067;GO:0060548;GO:0043068;GO:0048598;GO:0021915;GO:0000278;GO:0019219;GO:0090317;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:1901701;GO:0003279;GO:0048856;GO:0009914;GO:2000756;GO:0006417;GO:2000759;GO:0006412;GO:0048523;GO:0048522;GO:0008104;GO:0000082;GO:0042769;GO:0007165;GO:0007166;GO:0044707;GO:0045786;GO:0045787;GO:0002328;GO:0071310;GO:0071331;GO:0071333;GO:0060993;GO:0033036;GO:0002065;GO:0051051;GO:0051050;GO:2001141;GO:0072413;GO:0010033;GO:0070647;GO:0019827;GO:0018205;GO:0016567;GO:0009967;GO:0044783;GO:0003289;GO:0003284;GO:0003281;GO:0003283;GO:0050821;GO:0045321;GO:0006807;GO:0044267;GO:0009653;GO:0044260;GO:0001568;GO:0007049;GO:0006366;GO:0009887;GO:0034613;GO:0009889;GO:0050796;GO:0050794;GO:0060070;GO:0003230;GO:0003231;GO:0051234;GO:0050896;GO:0046826;GO:0046825;GO:0046822;GO:0046823;GO:0006518;GO:0051246;GO:0051649;GO:1903530;GO:0070887;GO:1903532;GO:0044699;GO:0032880;GO:0051248;GO:0072395;GO:0001944;GO:0051247;GO:0031399;GO:0031396;GO:0031397;GO:0021953;GO:0001838;GO:0045184;GO:0034248;GO:0072431;GO:0003179;GO:1902680;GO:1901985;GO:0048731;GO:0048736;GO:0016331;GO:0016337;GO:0035556;GO:0044772;GO:0003170;GO:0071158;GO:0072401;GO:0071156;GO:0045930;GO:0045935;GO:0030182;GO:0043543;GO:0010817;GO:2000758;GO:0070489;GO:0007267;GO:0042221;GO:0035295;GO:0070486;GO:0009746;GO:0044238;GO:0009743;GO:0002791;GO:0002793;GO:0044237;GO:0009749;GO:0090087;GO:0032024;GO:0019222;GO:0021515;GO:0021517;GO:0048584;GO:0048468;GO:0021510;GO:0072359;GO:0072358;GO:1901362;GO:1901360;GO:0009966;GO:0048869;GO:0001822;GO:0046879;GO:0032446;GO:0048513;GO:0048514;GO:0048518;GO:0048519;GO:0042127;GO:0003007;GO:2000045;GO:0044700;GO:1901564;GO:1901566;GO:0071322;GO:0016055;GO:0071326;GO:0002376;GO:0033554;GO:0098727;GO:0060828;GO:0003171;GO:0042981;GO:0097659;GO:0003174;GO:0090068;GO:0031570;GO:0031571;GO:0009306;GO:0045727;GO:0048646;GO:0018394;GO:0006810;GO:0012501;GO:0006950;GO:0001678;GO:0034654;GO:2000134;GO:0046903;GO:0051606;GO:0046907;GO:0031400;GO:0031401;GO:0001775;GO:0006355;GO:0006357;GO:0006351;GO:0003181;GO:0032774;GO:0043043;GO:0030154;GO:0015833;GO:1904950;GO:1904951;GO:0006139;GO:1903320;GO:1903321;GO:0032270;GO:0060563;GO:0060562;GO:0043009;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0032386;GO:0044271;GO:0072001;GO:0032879;GO:0016482;GO:0044770;GO:0051252;GO:0042110;GO:0010564;GO:0030217;GO:0071705;GO:0071704;GO:0002244;GO:0048729;GO:0071702;GO:0002320;GO:0003183;GO:0030330;GO:0006915;GO:0006913;GO:0023061;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044843;GO:0051179;GO:1902578;GO:0051641;GO:0000077;GO:0000075;GO:0051726;GO:0046649;GO:1902582;GO:0007093;GO:0035108;GO:0080090;GO:0035107;GO:1902402;GO:1902403;GO:1902400;GO:0031018;GO:0010605;GO:0010604;GO:0070727;GO:0010608;GO:0018193;GO:0019725;GO:0021522;GO:0031016;GO:0060255;GO:0090276;GO:0090277;GO:0003357;GO:0003215;GO:0003211;GO:0048878;GO:0060413;GO:0019438;GO:0060411;GO:0051224;GO:0021782;GO:1903650;GO:0060173;GO:0060174;GO:0032940;GO:0048485;GO:0048483;GO:0031365;GO:1901576;GO:0007346;GO:0050708;GO:0065007;GO:0001841;GO:0065008;GO:0035910;GO:0042063;GO:1901987;GO:0014009;GO:0036211;GO:0008150;GO:1901983;GO:0008152;GO:0060412;GO:0010948;GO:0031647;GO:0035148;GO:0023056;GO:0009790;GO:0034641;GO:0009792;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0022008;GO:0007417;GO:0042886;GO:0006611;GO:0022610;GO:0007507;GO:0060429;GO:0018076;GO:0045893;GO:0055082;GO:0043604;GO:0032269;GO:0032268;GO:1902806;GO:0043603;GO:0043170;GO:0002790;GO:0010628;GO:0045944;GO:0030098;GO:0030097;GO:1903508;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:1903047;GO:0090304;GO:0072175;GO:0044773;GO:0044774;GO:0010942;GO:0010941;GO:0002009;GO:0048844;GO:0033500;GO:0010467;GO:0048534;GO:2000761;GO:0010468;GO:0044249;GO:0007159;GO:0007155;GO:0007154;GO:0042770;GO:0048699;GO:0007399;GO:1902807;GO:0006977;GO:0015031;GO:0060840; regulation of intracellular protein transport;nuclear transport;nuclear export;regulation of secretion;positive regulation of secretion;regulation of transport;skeletal system development;cellular response to stimulus;signal transduction involved in DNA damage checkpoint;epithelial cell differentiation;protein acetylation;negative regulation of intracellular transport;regulation of response to stimulus;N-terminal protein amino acid acetylation;endocrine system development;heterocycle metabolic process;lymphocyte aggregation;response to monosaccharide;protein metabolic process;regulation of Wnt signaling pathway;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of canonical Wnt signaling pathway;positive regulation of RNA metabolic process;positive regulation of Wnt signaling pathway;positive regulation of protein transport;regulation of protein transport;signal transduction by p53 class mediator;regulation of biological process;peptide hormone secretion;insulin secretion;cardiac chamber development;cardiac chamber formation;cardiac chamber morphogenesis;intracellular protein transport;cardiac atrium morphogenesis;cardiac ventricle morphogenesis;heterocycle biosynthetic process;regulation of establishment of protein localization;single organism cell adhesion;regulation of cytoplasmic transport;cell-cell adhesion;tissue development;cell cycle arrest;macromolecule modification;leukocyte differentiation;immune system development;RNA metabolic process;positive regulation of protein secretion;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;ascending aorta development;aorta development;aorta morphogenesis;positive regulation of cellular amide metabolic process;regulation of cellular protein localization;somatic stem cell population maintenance;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;glial cell differentiation;mitotic G1/S transition checkpoint;negative regulation of cellular protein localization;negative regulation of cell cycle phase transition;positive regulation of cell proliferation;negative regulation of cell proliferation;tube morphogenesis;cell proliferation;cellular response to DNA damage stimulus;regulation of hormone secretion;urogenital system development;positive regulation of hormone secretion;regulation of cellular localization;homeostatic process;glucose homeostasis;cell cycle process;cell death;multicellular organism development;regulation of cellular macromolecule biosynthetic process;positive regulation of apoptotic process;regulation of programmed cell death;negative regulation of cell death;positive regulation of programmed cell death;embryonic morphogenesis;neural tube development;mitotic cell cycle;regulation of nucleobase-containing compound metabolic process;negative regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;cellular response to oxygen-containing compound;cardiac septum development;anatomical structure development;hormone transport;regulation of peptidyl-lysine acetylation;regulation of translation;regulation of N-terminal peptidyl-lysine acetylation;translation;negative regulation of cellular process;positive regulation of cellular process;protein localization;G1/S transition of mitotic cell cycle;DNA damage response, detection of DNA damage;signal transduction;cell surface receptor signaling pathway;single-multicellular organism process;negative regulation of cell cycle;positive regulation of cell cycle;pro-B cell differentiation;cellular response to organic substance;cellular response to hexose stimulus;cellular response to glucose stimulus;kidney morphogenesis;macromolecule localization;columnar/cuboidal epithelial cell differentiation;negative regulation of transport;positive regulation of transport;regulation of RNA biosynthetic process;signal transduction involved in mitotic cell cycle checkpoint;response to organic substance;protein modification by small protein conjugation or removal;stem cell population maintenance;peptidyl-lysine modification;protein ubiquitination;positive regulation of signal transduction;G1 DNA damage checkpoint;atrial septum primum morphogenesis;septum primum development;ventricular septum development;atrial septum development;protein stabilization;leukocyte activation;nitrogen compound metabolic process;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;blood vessel development;cell cycle;transcription from RNA polymerase II promoter;organ morphogenesis;cellular protein localization;regulation of biosynthetic process;regulation of insulin secretion;regulation of cellular process;canonical Wnt signaling pathway;cardiac atrium development;cardiac ventricle development;establishment of localization;response to stimulus;negative regulation of protein export from nucleus;regulation of protein export from nucleus;regulation of nucleocytoplasmic transport;negative regulation of nucleocytoplasmic transport;peptide metabolic process;regulation of protein metabolic process;establishment of localization in cell;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;single-organism process;regulation of protein localization;negative regulation of protein metabolic process;signal transduction involved in cell cycle checkpoint;vasculature development;positive regulation of protein metabolic process;regulation of protein modification process;regulation of protein ubiquitination;negative regulation of protein ubiquitination;central nervous system neuron differentiation;embryonic epithelial tube formation;establishment of protein localization;regulation of cellular amide metabolic process;signal transduction involved in mitotic G1 DNA damage checkpoint;heart valve morphogenesis;positive regulation of RNA biosynthetic process;positive regulation of protein acetylation;system development;appendage development;morphogenesis of embryonic epithelium;single organismal cell-cell adhesion;intracellular signal transduction;mitotic cell cycle phase transition;heart valve development;positive regulation of cell cycle arrest;signal transduction involved in DNA integrity checkpoint;regulation of cell cycle arrest;negative regulation of mitotic cell cycle;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;protein acylation;regulation of hormone levels;positive regulation of peptidyl-lysine acetylation;T cell aggregation;cell-cell signaling;response to chemical;tube development;leukocyte aggregation;response to hexose;primary metabolic process;response to carbohydrate;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;response to glucose;regulation of peptide transport;positive regulation of insulin secretion;regulation of metabolic process;cell differentiation in spinal cord;ventral spinal cord development;positive regulation of response to stimulus;cell development;spinal cord development;circulatory system development;cardiovascular system development;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of signal transduction;cellular developmental process;kidney development;hormone secretion;protein modification by small protein conjugation;animal organ development;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;heart morphogenesis;regulation of G1/S transition of mitotic cell cycle;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;cellular response to carbohydrate stimulus;Wnt signaling pathway;cellular response to monosaccharide stimulus;immune system process;cellular response to stress;maintenance of cell number;regulation of canonical Wnt signaling pathway;atrioventricular valve development;regulation of apoptotic process;nucleic acid-templated transcription;mitral valve development;positive regulation of cell cycle process;DNA integrity checkpoint;mitotic G1 DNA damage checkpoint;protein secretion;positive regulation of translation;anatomical structure formation involved in morphogenesis;peptidyl-lysine acetylation;transport;programmed cell death;response to stress;cellular glucose homeostasis;nucleobase-containing compound biosynthetic process;negative regulation of G1/S transition of mitotic cell cycle;secretion;detection of stimulus;intracellular transport;negative regulation of protein modification process;positive regulation of protein modification process;cell activation;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;atrioventricular valve morphogenesis;RNA biosynthetic process;peptide biosynthetic process;cell differentiation;peptide transport;negative regulation of establishment of protein localization;positive regulation of establishment of protein localization;nucleobase-containing compound metabolic process;regulation of protein modification by small protein conjugation or removal;negative regulation of protein modification by small protein conjugation or removal;positive regulation of cellular protein metabolic process;neuroepithelial cell differentiation;epithelial tube morphogenesis;chordate embryonic development;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of intracellular transport;cellular nitrogen compound biosynthetic process;renal system development;regulation of localization;cytosolic transport;cell cycle phase transition;regulation of RNA metabolic process;T cell activation;regulation of cell cycle process;T cell differentiation;nitrogen compound transport;organic substance metabolic process;hematopoietic progenitor cell differentiation;tissue morphogenesis;organic substance transport;lymphoid progenitor cell differentiation;mitral valve morphogenesis;DNA damage response, signal transduction by p53 class mediator;apoptotic process;nucleocytoplasmic transport;signal release;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell cycle G1/S phase transition;localization;single-organism localization;cellular localization;DNA damage checkpoint;cell cycle checkpoint;regulation of cell cycle;lymphocyte activation;single-organism intracellular transport;mitotic cell cycle checkpoint;limb morphogenesis;regulation of primary metabolic process;appendage morphogenesis;signal transduction involved in mitotic DNA damage checkpoint;signal transduction involved in mitotic DNA integrity checkpoint;intracellular signal transduction involved in G1 DNA damage checkpoint;endocrine pancreas development;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;posttranscriptional regulation of gene expression;peptidyl-amino acid modification;cellular homeostasis;spinal cord motor neuron differentiation;pancreas development;regulation of macromolecule metabolic process;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;noradrenergic neuron differentiation;cardiac right ventricle morphogenesis;cardiac ventricle formation;chemical homeostasis;atrial septum morphogenesis;aromatic compound biosynthetic process;cardiac septum morphogenesis;negative regulation of protein transport;glial cell development;negative regulation of cytoplasmic transport;limb development;limb bud formation;secretion by cell;sympathetic nervous system development;autonomic nervous system development;N-terminal protein amino acid modification;organic substance biosynthetic process;regulation of mitotic cell cycle;regulation of protein secretion;biological regulation;neural tube formation;regulation of biological quality;ascending aorta morphogenesis;gliogenesis;regulation of cell cycle phase transition;glial cell proliferation;protein modification process;biological_process;regulation of protein acetylation;metabolic process;ventricular septum morphogenesis;negative regulation of cell cycle process;regulation of protein stability;tube formation;positive regulation of signaling;embryo development;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;neurogenesis;central nervous system development;amide transport;protein export from nucleus;biological adhesion;heart development;epithelium development;N-terminal peptidyl-lysine acetylation;positive regulation of transcription, DNA-templated;cellular chemical homeostasis;amide biosynthetic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of cell cycle G1/S phase transition;cellular amide metabolic process;macromolecule metabolic process;peptide secretion;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;lymphocyte differentiation;hemopoiesis;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;epithelial tube formation;mitotic DNA damage checkpoint;mitotic DNA integrity checkpoint;positive regulation of cell death;regulation of cell death;morphogenesis of an epithelium;artery morphogenesis;carbohydrate homeostasis;gene expression;hematopoietic or lymphoid organ development;positive regulation of N-terminal peptidyl-lysine acetylation;regulation of gene expression;cellular biosynthetic process;leukocyte cell-cell adhesion;cell adhesion;cell communication;signal transduction in response to DNA damage;generation of neurons;nervous system development;negative regulation of cell cycle G1/S phase transition;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;protein transport;artery development; 6;6;8;5;4;4;5;3;7;6;8;4;3;8;5;4;7;6;4;5;3;3;4;6;5;5;4;5;6;2;7;6;4;4;4;6;5;5;5;5;3;6;4;4;5;5;6;3;5;5;5;5;4;6;6;5;5;5;6;6;6;7;3;6;4;4;4;3;5;4;5;4;4;4;7;4;4;4;6;6;5;4;5;4;4;5;5;4;6;3;4;3;4;5;4;3;5;8;6;9;6;3;3;4;7;4;4;5;3;4;4;8;5;8;7;5;3;7;3;3;6;6;4;7;4;8;9;4;7;6;6;5;5;5;3;3;5;3;4;4;4;7;4;5;4;6;3;7;5;5;3;2;5;7;7;6;5;5;4;5;4;4;2;4;5;5;5;5;6;8;8;6;6;4;5;8;4;6;7;4;4;5;4;5;6;4;6;6;6;5;5;6;7;4;8;4;4;3;4;6;7;3;5;6;5;3;8;5;6;3;6;4;3;4;5;5;5;5;4;4;4;4;6;8;4;4;2;2;4;5;7;3;4;5;6;6;7;2;4;3;6;5;6;7;6;5;6;7;5;6;3;9;4;5;3;6;5;7;5;3;5;6;6;4;6;7;6;5;6;6;5;6;3;3;4;7;7;5;8;5;7;2;2;2;4;7;5;5;5;3;6;5;5;5;5;6;5;3;6;4;5;7;6;7;6;7;5;3;5;4;4;6;2;3;3;6;5;4;4;5;6;5;4;4;7;7;8;4;4;4;4;6;7;4;5;4;4;5;5;7;6;5;5;5;5;4;4;5;5;5;4;4;5;5;7;4;5;6;2;5;3;4;7;6;4;5;1;7;2;5;5;4;4;3;5;4;6;2;5;3;4;4;6;5;5;6;2;4;5;9;6;5;6;5;5;7;5;4;6;5;7;5;5;7;5;5;4;4;4;5;5;5;6;6;4;4;5;5;6;5;4;9;5;4;5;3;4;6;7;5;7;7;5;5; GO:0044798;GO:0044428;GO:0044424;GO:0044422;GO:0005654;GO:0044464;GO:0070013;GO:0043234;GO:0043231;GO:0043233;GO:0043227;GO:0031974;GO:0043229;GO:0005622;GO:0043226;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005739;GO:0031981;GO:0005667;GO:0005623;GO:0032991;GO:0005575; nuclear transcription factor complex;nuclear part;intracellular part;organelle part;nucleoplasm;cell part;intracellular organelle lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;membrane-bounded organelle;membrane-enclosed lumen;intracellular organelle;intracellular;organelle;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;mitochondrion;nuclear lumen;transcription factor complex;cell;macromolecular complex;cellular_component; 5;4;3;2;5;2;4;3;4;3;3;2;3;3;2;3;4;4;5;5;5;4;2;2;1; GO:0001067;GO:0044212;GO:0005488;GO:0000976;GO:0043565;GO:0001047;GO:0001046;GO:0003700;GO:1901363;GO:0003674;GO:0003676;GO:0003677;GO:0097159;GO:1990837;GO:0098811;GO:0001228;GO:0001076;GO:0001077;GO:0001071;GO:0003713;GO:0003712;GO:0000975;GO:0000989;GO:0000988;GO:0000982;GO:0000981;GO:0001104;GO:0001105;GO:0003690;GO:0001191;GO:0001190; regulatory region nucleic acid binding;transcription regulatory region DNA binding;binding;transcription regulatory region sequence-specific DNA binding;sequence-specific DNA binding;core promoter binding;core promoter sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding;heterocyclic compound binding;molecular_function;nucleic acid binding;DNA binding;organic cyclic compound binding;sequence-specific double-stranded DNA binding;transcriptional repressor activity, RNA polymerase II activating transcription factor binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;transcription factor activity, RNA polymerase II transcription factor binding;transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;nucleic acid binding transcription factor activity;transcription coactivator activity;transcription cofactor activity;regulatory region DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;RNA polymerase II transcription cofactor activity;RNA polymerase II transcription coactivator activity;double-stranded DNA binding;transcriptional repressor activity, RNA polymerase II transcription factor binding;transcriptional activator activity, RNA polymerase II transcription factor binding; 5;7;2;8;6;8;9;3;3;1;4;5;3;7;6;5;4;6;2;5;4;6;3;2;5;4;5;6;6;5;7; K23581 IPR009071;IPR017386; High mobility group box domain;Transcription factor SOX-11/4; nucleus Hs4507163 927.0 K [K] Transcription; Q9HC10 Otoferlin OS=Homo sapiens OX=9606 GN=OTOF PE=1 SV=3 - [OTOF_HUMAN] 0.994 1.079 1.06 0.991 1.149 0.686 0.921223355 nan 0.862489121 nan 0.982391103 nan 0.597040905 nan GO:0099643;GO:0061025;GO:0061024;GO:0001505;GO:0051656;GO:0051650;GO:0071840;GO:0048513;GO:0097479;GO:0099504;GO:0007605;GO:0007600;GO:0006836;GO:0097480;GO:0003008;GO:0044700;GO:0016192;GO:0044707;GO:0098916;GO:0048489;GO:0090102;GO:0006887;GO:0016043;GO:0045055;GO:0065007;GO:0065008;GO:0050954;GO:0006810;GO:0008150;GO:0051234;GO:0046903;GO:0046907;GO:0016079;GO:0099531;GO:0099536;GO:0099537;GO:0051648;GO:0007268;GO:0023052;GO:0044699;GO:1902578;GO:0017156;GO:0032502;GO:0032501;GO:0050877;GO:0009987;GO:0016482;GO:0048839;GO:0007423;GO:0032940;GO:0048731;GO:0007275;GO:0043583;GO:0023061;GO:0044767;GO:0044765;GO:0044763;GO:0007269;GO:0051649;GO:0007267;GO:0007154;GO:0051179;GO:0051640;GO:0051641;GO:0048856;GO:1902582;GO:1902580; signal release from synapse;membrane fusion;membrane organization;regulation of neurotransmitter levels;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;animal organ development;synaptic vesicle localization;synaptic vesicle cycle;sensory perception of sound;sensory perception;neurotransmitter transport;establishment of synaptic vesicle localization;system process;single organism signaling;vesicle-mediated transport;single-multicellular organism process;anterograde trans-synaptic signaling;synaptic vesicle transport;cochlea development;exocytosis;cellular component organization;regulated exocytosis;biological regulation;regulation of biological quality;sensory perception of mechanical stimulus;transport;biological_process;establishment of localization;secretion;intracellular transport;synaptic vesicle exocytosis;presynaptic process involved in synaptic transmission;synaptic signaling;trans-synaptic signaling;vesicle localization;synaptic transmission;signaling;single-organism process;single-organism localization;calcium ion regulated exocytosis;developmental process;multicellular organismal process;neurological system process;cellular process;cytosolic transport;inner ear development;sensory organ development;secretion by cell;system development;multicellular organism development;ear development;signal release;single-organism developmental process;single-organism transport;single-organism cellular process;neurotransmitter secretion;establishment of localization in cell;cell-cell signaling;cell communication;localization;organelle localization;cellular localization;anatomical structure development;single-organism intracellular transport;single-organism cellular localization; 6;5;4;4;4;5;2;4;6;5;7;5;5;6;3;3;5;3;7;5;4;5;3;6;2;3;6;4;1;3;5;5;3;2;5;6;5;8;2;2;3;7;2;2;4;2;6;4;4;4;4;4;5;5;3;4;3;3;4;4;4;2;4;3;3;5;4; GO:0005783;GO:0005789;GO:0030054;GO:0012505;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0099501;GO:0099503;GO:0098588;GO:0098589;GO:0005829;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0044432;GO:0031224;GO:0005886;GO:0097708;GO:0012506;GO:0030672;GO:0044446;GO:0044444;GO:0008021;GO:0042175;GO:0005737;GO:0045177;GO:0031090;GO:0031410;GO:0045178;GO:0044456;GO:0044459;GO:0016323;GO:0030658;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0045202;GO:0030133;GO:0098805;GO:0070382;GO:0097458;GO:0005575;GO:0098793; endoplasmic reticulum;endoplasmic reticulum membrane;cell junction;endomembrane system;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;exocytic vesicle membrane;secretory vesicle;bounding membrane of organelle;membrane region;cytosol;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;plasma membrane region;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;endoplasmic reticulum part;intrinsic component of membrane;plasma membrane;intracellular vesicle;vesicle membrane;synaptic vesicle membrane;intracellular organelle part;cytoplasmic part;synaptic vesicle;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasm;apical part of cell;organelle membrane;cytoplasmic vesicle;basal part of cell;synapse part;plasma membrane part;basolateral plasma membrane;transport vesicle membrane;cytoplasmic vesicle membrane;cell part;cell;intracellular;cell periphery;synapse;transport vesicle;whole membrane;exocytic vesicle;neuron part;cellular_component;presynapse; 4;3;2;3;4;5;4;2;5;5;6;4;3;5;4;3;2;2;4;3;3;2;4;4;3;3;4;4;3;3;4;3;3;4;3;3;5;3;2;3;4;4;5;2;2;3;3;2;4;3;5;3;1;3; GO:0046872;GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509; metal ion binding;molecular_function;binding;cation binding;ion binding;calcium ion binding; 5;1;2;4;3;6; K19949 IPR032362;IPR000008;IPR029996;IPR012968;IPR012561; Ferlin, C-terminal domain;C2 domain;Otoferlin;FerIin domain;Ferlin B-domain; cytosol Hs4758856 2531.0 M [M] Cell wall/membrane/envelope biogenesis; Q5TAX3 Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3 - [TUT4_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:0031050;GO:1901360;GO:1901361;GO:0044710;GO:0010605;GO:0010608;GO:0043043;GO:0040029;GO:0048519;GO:0034470;GO:0060255;GO:1901564;GO:0010033;GO:0046483;GO:0019827;GO:0019538;GO:0019439;GO:0031054;GO:0044707;GO:0009892;GO:0034645;GO:0009890;GO:0006807;GO:0034661;GO:0034660;GO:0070918;GO:1901576;GO:1901575;GO:0044265;GO:0044260;GO:0071359;GO:0065007;GO:0014070;GO:0043331;GO:0017148;GO:0009889;GO:0051716;GO:0046700;GO:0098727;GO:0008150;GO:0008152;GO:0034655;GO:0050794;GO:0016070;GO:0044271;GO:0044270;GO:1901698;GO:1901699;GO:0010556;GO:0006518;GO:0010558;GO:0071310;GO:0044248;GO:0044249;GO:0034641;GO:0070887;GO:1901566;GO:0044699;GO:0006139;GO:0051248;GO:0051246;GO:0016458;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0034249;GO:0034248;GO:0043604;GO:0032269;GO:0032268;GO:0043603;GO:0071407;GO:0010629;GO:0043170;GO:0050896;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0010586;GO:0016441;GO:0051171;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0006401;GO:0010468;GO:0044267;GO:0031123;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0031047;GO:0051172;GO:0042221;GO:0009056;GO:0009057;GO:0010587;GO:0044238;GO:0035194;GO:0035195;GO:0035196;GO:0044237;GO:0048523;GO:0006417;GO:0006412;GO:0006396; regulation of primary metabolic process;regulation of metabolic process;dsRNA fragmentation;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;posttranscriptional regulation of gene expression;peptide biosynthetic process;regulation of gene expression, epigenetic;negative regulation of biological process;ncRNA processing;regulation of macromolecule metabolic process;organonitrogen compound metabolic process;response to organic substance;heterocycle metabolic process;stem cell population maintenance;protein metabolic process;aromatic compound catabolic process;pre-miRNA processing;single-multicellular organism process;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;ncRNA catabolic process;ncRNA metabolic process;production of small RNA involved in gene silencing by RNA;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;cellular response to dsRNA;biological regulation;response to organic cyclic compound;response to dsRNA;negative regulation of translation;regulation of biosynthetic process;cellular response to stimulus;heterocycle catabolic process;maintenance of cell number;biological_process;metabolic process;nucleobase-containing compound catabolic process;regulation of cellular process;RNA metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;response to nitrogen compound;cellular response to nitrogen compound;regulation of macromolecule biosynthetic process;peptide metabolic process;negative regulation of macromolecule biosynthetic process;cellular response to organic substance;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular response to chemical stimulus;organonitrogen compound biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;regulation of protein metabolic process;gene silencing;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;amide biosynthetic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;cellular response to organic cyclic compound;negative regulation of gene expression;macromolecule metabolic process;response to stimulus;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;miRNA metabolic process;posttranscriptional gene silencing;regulation of nitrogen compound metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;RNA catabolic process;regulation of gene expression;cellular protein metabolic process;RNA 3'-end processing;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;gene silencing by RNA;negative regulation of nitrogen compound metabolic process;response to chemical;catabolic process;macromolecule catabolic process;miRNA catabolic process;primary metabolic process;posttranscriptional gene silencing by RNA;gene silencing by miRNA;production of miRNAs involved in gene silencing by miRNA;cellular metabolic process;negative regulation of cellular process;regulation of translation;translation;RNA processing; 4;3;4;4;5;3;4;6;6;6;2;7;4;4;4;4;4;4;5;7;3;3;5;4;3;7;6;5;4;4;5;4;6;2;5;5;6;4;3;5;3;1;2;5;3;5;5;5;4;5;5;5;5;5;4;4;4;4;5;2;4;5;5;4;2;2;2;4;5;5;6;5;5;5;6;5;4;2;5;5;4;4;5;7;5;4;6;6;2;3;5;6;5;5;7;3;3;5;3;5;4;3;3;5;8;3;6;7;6;3;3;6;6;6; GO:0031974;GO:0031982;GO:0031981;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0005615;GO:0044464;GO:0005623;GO:0043228;GO:0044424;GO:0070062;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;vesicle;nuclear lumen;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasm;nucleolus;nucleus;extracellular space;cell part;cell;non-membrane-bounded organelle;intracellular part;extracellular exosome;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;5;3;4;4;3;4;2;2;3;3;3;2;3;4;5;5;3;2;2;3;3;4;3;1;4;2; GO:0008270;GO:1901363;GO:0016740;GO:0046872;GO:0050265;GO:0003674;GO:0005488;GO:0003676;GO:0043169;GO:0016779;GO:0003824;GO:0097159;GO:0070569;GO:0043167;GO:0044822;GO:0003723;GO:0016772;GO:0046914; zinc ion binding;heterocyclic compound binding;transferase activity;metal ion binding;RNA uridylyltransferase activity;molecular_function;binding;nucleic acid binding;cation binding;nucleotidyltransferase activity;catalytic activity;organic cyclic compound binding;uridylyltransferase activity;ion binding;poly(A) RNA binding;RNA binding;transferase activity, transferring phosphorus-containing groups;transition metal ion binding; 7;3;3;5;7;1;2;4;4;5;2;3;6;3;6;5;4;6; K13291 IPR002934;IPR002058;IPR001878; Polymerase, nucleotidyl transferase domain;PAP/25A-associated;Zinc finger, CCHC-type; nucleus Hs22044581 3407.0 D [D] Cell cycle control, cell division, chromosome partitioning; Q96JH8 Ras-associating and dilute domain-containing protein OS=Homo sapiens OX=9606 GN=RADIL PE=1 SV=5 - [RADIL_HUMAN] 0.849 1.146 1.232 0.744 1.18 0.867 0.740837696 nan 0.630508475 nan 1.07504363 nan 0.734745763 nan GO:0034446;GO:0030154;GO:0048468;GO:0007275;GO:0050789;GO:0023052;GO:0007165;GO:0009653;GO:0044699;GO:0051716;GO:0000904;GO:0000902;GO:0048869;GO:0016043;GO:0032989;GO:0065007;GO:0071840;GO:0022610;GO:0032502;GO:0031589;GO:0098602;GO:0032501;GO:0009987;GO:0050794;GO:0044767;GO:0008150;GO:0007155;GO:0007154;GO:0044700;GO:0044707;GO:0050896;GO:0048856;GO:0044763; substrate adhesion-dependent cell spreading;cell differentiation;cell development;multicellular organism development;regulation of biological process;signaling;signal transduction;anatomical structure morphogenesis;single-organism process;cellular response to stimulus;cell morphogenesis involved in differentiation;cell morphogenesis;cellular developmental process;cellular component organization;cellular component morphogenesis;biological regulation;cellular component organization or biogenesis;biological adhesion;developmental process;cell-substrate adhesion;single organism cell adhesion;multicellular organismal process;cellular process;regulation of cellular process;single-organism developmental process;biological_process;cell adhesion;cell communication;single organism signaling;single-multicellular organism process;response to stimulus;anatomical structure development;single-organism cellular process; 4;5;4;4;2;2;4;3;2;3;5;5;4;3;4;2;2;2;2;4;3;2;2;3;3;1;3;4;3;3;2;3;3; GO:0099512;GO:0099513;GO:0043229;GO:0015630;GO:0005874;GO:0043226;GO:0005856;GO:0005575;GO:0044430;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0043228;GO:0044424;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;intracellular organelle;microtubule cytoskeleton;microtubule;organelle;cytoskeleton;cellular_component;cytoskeletal part;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;non-membrane-bounded organelle;intracellular part;organelle part; 2;3;3;6;4;2;5;1;4;4;2;2;3;3;3;3;2; IPR001478;IPR000159;IPR002710;IPR008984;IPR029071; PDZ domain;Ras-associating (RA) domain;Dilute domain;SMAD/FHA domain;Ubiquitin-related domain; mitochondria Hs8922354 1330.0 Z [Z] Cytoskeleton; Q8TDM6 Disks large homolog 5 OS=Homo sapiens OX=9606 GN=DLG5 PE=1 SV=4 - [DLG5_HUMAN] 0.957 1.042 0.86 1.245 0.917 1.884 0.918426104 nan 1.357688113 nan 0.825335893 nan 2.054525627 nan GO:0008105;GO:0008104;GO:0045216;GO:0007163;GO:0007165;GO:0071840;GO:0051716;GO:0048869;GO:0001822;GO:0048513;GO:0030855;GO:0048519;GO:0033036;GO:0060541;GO:0045186;GO:0072044;GO:1902414;GO:0044700;GO:0044707;GO:0060322;GO:0007043;GO:0022607;GO:0061245;GO:0045197;GO:0001763;GO:0035556;GO:0042981;GO:0050789;GO:0035088;GO:0016043;GO:0065003;GO:0065007;GO:0009887;GO:0098602;GO:0098609;GO:0009888;GO:0050794;GO:0012501;GO:0034333;GO:0008150;GO:0007420;GO:0050896;GO:0006915;GO:0071896;GO:0070271;GO:0030154;GO:0023052;GO:0016337;GO:0009653;GO:0044699;GO:0007417;GO:0045176;GO:0060441;GO:0060562;GO:0022610;GO:0032502;GO:0008285;GO:0032501;GO:0035239;GO:0060425;GO:0060429;GO:0001655;GO:0001656;GO:0072001;GO:0034329;GO:0030859;GO:0048731;GO:0042127;GO:0030323;GO:0030324;GO:0043933;GO:0034332;GO:0034330;GO:0048754;GO:0008219;GO:0010941;GO:0007275;GO:0002009;GO:0071822;GO:0008283;GO:0072205;GO:0043067;GO:0048729;GO:0009987;GO:0061138;GO:0006461;GO:0044767;GO:0001738;GO:0044763;GO:0007155;GO:0007154;GO:0035295;GO:0051179;GO:0007399;GO:0048856;GO:0044085;GO:0030901;GO:0043297;GO:0048523; asymmetric protein localization;protein localization;cell-cell junction organization;establishment or maintenance of cell polarity;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;kidney development;animal organ development;epithelial cell differentiation;negative regulation of biological process;macromolecule localization;respiratory system development;zonula adherens assembly;collecting duct development;protein localization to cell junction;single organism signaling;single-multicellular organism process;head development;cell-cell junction assembly;cellular component assembly;establishment or maintenance of bipolar cell polarity;establishment or maintenance of epithelial cell apical/basal polarity;morphogenesis of a branching structure;intracellular signal transduction;regulation of apoptotic process;regulation of biological process;establishment or maintenance of apical/basal cell polarity;cellular component organization;macromolecular complex assembly;biological regulation;organ morphogenesis;single organism cell adhesion;cell-cell adhesion;tissue development;regulation of cellular process;programmed cell death;adherens junction assembly;biological_process;brain development;response to stimulus;apoptotic process;protein localization to adherens junction;protein complex biogenesis;cell differentiation;signaling;single organismal cell-cell adhesion;anatomical structure morphogenesis;single-organism process;central nervous system development;apical protein localization;epithelial tube branching involved in lung morphogenesis;epithelial tube morphogenesis;biological adhesion;developmental process;negative regulation of cell proliferation;multicellular organismal process;tube morphogenesis;lung morphogenesis;epithelium development;urogenital system development;metanephros development;renal system development;cell junction assembly;polarized epithelial cell differentiation;system development;regulation of cell proliferation;respiratory tube development;lung development;macromolecular complex subunit organization;adherens junction organization;cell junction organization;branching morphogenesis of an epithelial tube;cell death;regulation of cell death;multicellular organism development;morphogenesis of an epithelium;protein complex subunit organization;cell proliferation;metanephric collecting duct development;regulation of programmed cell death;tissue morphogenesis;cellular process;morphogenesis of a branching epithelium;protein complex assembly;single-organism developmental process;morphogenesis of a polarized epithelium;single-organism cellular process;cell adhesion;cell communication;tube development;localization;nervous system development;anatomical structure development;cellular component biogenesis;midbrain development;apical junction assembly;negative regulation of cellular process; 5;4;5;4;4;2;3;4;4;4;6;2;3;5;7;4;5;3;3;4;6;4;5;7;4;5;6;2;6;3;5;2;4;3;4;4;3;5;6;1;4;2;6;6;4;5;2;4;3;2;5;6;6;5;2;2;4;2;4;5;5;5;5;5;5;7;4;4;4;4;4;6;4;5;4;4;4;5;5;3;5;5;4;2;5;5;3;6;3;3;4;4;2;5;3;3;4;7;3; GO:0016020;GO:0044424;GO:0030054;GO:0070161;GO:0005737;GO:0005913;GO:0005911;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005886;GO:0005575;GO:0005912; membrane;intracellular part;cell junction;anchoring junction;cytoplasm;cell-cell adherens junction;cell-cell junction;cell part;cell;intracellular;cell periphery;plasma membrane;cellular_component;adherens junction; 2;3;2;3;4;4;3;2;2;3;3;3;1;4; GO:0003674;GO:0032947;GO:0008013;GO:0008092;GO:0030159;GO:0005515;GO:0005488;GO:0005198; molecular_function;protein complex scaffold;beta-catenin binding;cytoskeletal protein binding;receptor signaling complex scaffold activity;protein binding;binding;structural molecule activity; 1;3;4;4;4;3;2;2; IPR001478;IPR008145;IPR001452;IPR035537;IPR006907;IPR008144;IPR001315;IPR027417;IPR011029; PDZ domain;Guanylate kinase/L-type calcium channel beta subunit;SH3 domain;Disks large homologue 5, SH3 domain;Domain of unknown function DUF622;Guanylate kinase-like domain;CARD domain;P-loop containing nucleoside triphosphate hydrolase;Death-like domain; nucleus Hs22052226 1399.0 F [F] Nucleotide transport and metabolism; Q96QU6 1-aminocyclopropane-1-carboxylate synthase-like protein 1 OS=Homo sapiens OX=9606 GN=ACCS PE=1 SV=1 - [1A1L1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0009058;GO:0008150;GO:0008152; biosynthetic process;biological_process;metabolic process; 3;1;2; GO:0043168;GO:0005515;GO:0048037;GO:0097159;GO:0043167;GO:0003824;GO:0030170;GO:0003674;GO:0046983;GO:0042803;GO:1901363;GO:0042802;GO:0005488; anion binding;protein binding;cofactor binding;organic cyclic compound binding;ion binding;catalytic activity;pyridoxal phosphate binding;molecular_function;protein dimerization activity;protein homodimerization activity;heterocyclic compound binding;identical protein binding;binding; 4;3;3;3;3;2;4;1;4;5;3;4;2; IPR004839;IPR015422;IPR015424;IPR015421; Aminotransferase, class I/classII;Pyridoxal phosphate-dependent transferase, subdomain 2;Pyridoxal phosphate-dependent transferase;Pyridoxal phosphate-dependent transferase, major region, subdomain 1; nucleus Hs14211921 1040.0 T [T] Signal transduction mechanisms; O75629 Protein CREG1 OS=Homo sapiens OX=9606 GN=CREG1 PE=1 SV=1 - [CREG1_HUMAN] 1.049 1.376 0.737 0.829 1.392 0.451 0.762354651 nan 0.595545977 nan 0.535610465 nan 0.323994253 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0006357;GO:0044767;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0051253;GO:0051252;GO:0043170;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0007275;GO:0040008;GO:2000112;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0040007;GO:0044238;GO:0048856;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;single-organism developmental process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;developmental process;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organism development;regulation of growth;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;growth;primary metabolic process;anatomical structure development;cellular metabolic process;negative regulation of cellular process; 4;3;5;4;4;2;4;6;4;3;5;3;4;3;2;7;4;4;2;7;5;4;3;1;2;5;5;5;6;7;3;6;5;6;4;4;5;2;4;2;2;3;2;4;7;7;5;5;4;5;5;4;4;5;4;3;6;3;5;5;5;5;5;6;3;5;4;4;2;3;3;3;3; GO:0031982;GO:0005615;GO:0043234;GO:0043230;GO:0005667;GO:0044424;GO:0044421;GO:0005622;GO:0043227;GO:0044464;GO:0005623;GO:0070062;GO:0043226;GO:1903561;GO:0032991;GO:0005575;GO:0005576; vesicle;extracellular space;protein complex;extracellular organelle;transcription factor complex;intracellular part;extracellular region part;intracellular;membrane-bounded organelle;cell part;cell;extracellular exosome;organelle;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 4;3;3;3;4;3;2;3;3;2;2;4;2;3;2;1;2; GO:1901363;GO:0003714;GO:0003712;GO:0000166;GO:0000988;GO:0097367;GO:0003674;GO:0005488;GO:0000989;GO:0003824;GO:0036094;GO:0097159;GO:0032553;GO:0016491;GO:0048037;GO:1901265;GO:0010181; heterocyclic compound binding;transcription corepressor activity;transcription cofactor activity;nucleotide binding;transcription factor activity, protein binding;carbohydrate derivative binding;molecular_function;binding;transcription factor activity, transcription factor binding;catalytic activity;small molecule binding;organic cyclic compound binding;ribonucleotide binding;oxidoreductase activity;cofactor binding;nucleoside phosphate binding;FMN binding; 3;5;4;4;2;3;1;2;3;2;3;3;4;3;3;4;4; IPR014631;IPR012349; Cellular repressor of E1A-stimulated genes (CREG);FMN-binding split barrel; extracellular Hs4503037 455.0 K [K] Transcription; Q9BRX2 Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2 - [PELO_HUMAN] 0.583 0.584 2.704 0.695 nan 1.803 0.998287671 nan nan nan 4.630136986 nan nan nan GO:0071025;GO:0044248;GO:0034641;GO:0006807;GO:0044237;GO:0051301;GO:0043170;GO:1901360;GO:1901361;GO:0006139;GO:1901575;GO:0044265;GO:0044260;GO:0070481;GO:0008283;GO:0016043;GO:0071704;GO:0071840;GO:0006401;GO:0006402;GO:0006996;GO:0044238;GO:0007049;GO:0009987;GO:0006725;GO:0046700;GO:0019439;GO:0008150;GO:0008152;GO:0034655;GO:0009056;GO:0009057;GO:0046483;GO:0016070;GO:0016071;GO:0044699;GO:0070966;GO:0044270;GO:0090304;GO:0051276;GO:0000956;GO:0044763; RNA surveillance;cellular catabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;cell division;macromolecule metabolic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;nucleobase-containing compound metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;nuclear-transcribed mRNA catabolic process, non-stop decay;cell proliferation;cellular component organization;organic substance metabolic process;cellular component organization or biogenesis;RNA catabolic process;mRNA catabolic process;organelle organization;primary metabolic process;cell cycle;cellular process;cellular aromatic compound metabolic process;heterocycle catabolic process;aromatic compound catabolic process;biological_process;metabolic process;nucleobase-containing compound catabolic process;catabolic process;macromolecule catabolic process;heterocycle metabolic process;RNA metabolic process;mRNA metabolic process;single-organism process;nuclear-transcribed mRNA catabolic process, no-go decay;cellular nitrogen compound catabolic process;nucleic acid metabolic process;chromosome organization;nuclear-transcribed mRNA catabolic process;single-organism cellular process; 7;4;4;3;3;4;4;4;5;4;4;5;4;9;3;3;3;2;6;7;4;3;4;2;4;5;5;1;2;5;3;5;4;5;6;2;9;5;5;5;8;3; GO:0043231;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 4;3;2;4;5;2;3;2;3;1;3; GO:0016787;GO:0043169;GO:0003674;GO:0043167;GO:0046872;GO:0016788;GO:0003824;GO:0004519;GO:0004518;GO:0005488; hydrolase activity;cation binding;molecular_function;ion binding;metal ion binding;hydrolase activity, acting on ester bonds;catalytic activity;endonuclease activity;nuclease activity;binding; 3;4;1;3;5;4;2;6;5;2; K06965 map03015; mRNA surveillance pathway; IPR005140;IPR005141;IPR005142;IPR029064;IPR004405; eRF1 domain 1/Pelota-like;eRF1 domain 2;eRF1 domain 3;50S ribosomal protein L30e-like;Translation release factor pelota; nucleus Hs21359907 801.0 J [J] Translation, ribosomal structure and biogenesis; Q15256 Receptor-type tyrosine-protein phosphatase R OS=Homo sapiens OX=9606 GN=PTPRR PE=1 SV=2 - [PTPRR_HUMAN] 1.124 1.077 0.693 1.146 1.321 0.71 1.04363974 nan 0.867524603 nan 0.643454039 nan 0.537471612 nan GO:0019220;GO:0080090;GO:0019222;GO:0006470;GO:0048585;GO:0048583;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0044707;GO:0023014;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0048869;GO:0000165;GO:0048519;GO:0048699;GO:0060255;GO:0042325;GO:0044700;GO:0042326;GO:0010631;GO:0010632;GO:0048870;GO:0019538;GO:0010633;GO:0010648;GO:0009892;GO:0006928;GO:0051674;GO:0035556;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0016477;GO:0043409;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0051239;GO:1902532;GO:0031400;GO:1902531;GO:0051174;GO:0070372;GO:2000145;GO:2000146;GO:0010563;GO:0008152;GO:0016311;GO:0016310;GO:0030154;GO:0009790;GO:0009792;GO:0023052;GO:0038127;GO:0023051;GO:0001667;GO:0010646;GO:0044699;GO:0043408;GO:0051248;GO:0001701;GO:0051241;GO:0051246;GO:0031399;GO:0043009;GO:0032502;GO:0032501;GO:0009987;GO:0051271;GO:0001933;GO:0040012;GO:0038128;GO:0032879;GO:0090132;GO:0090130;GO:0032269;GO:0032268;GO:0043170;GO:0048731;GO:0070373;GO:0050896;GO:0070371;GO:0031324;GO:0031323;GO:0007275;GO:0071704;GO:0030336;GO:0006468;GO:0030334;GO:0030182;GO:0045936;GO:0006464;GO:0044767;GO:0044763;GO:0007154;GO:0022008;GO:0051179;GO:0040011;GO:0044238;GO:0040013;GO:0051270;GO:0007399;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0023057;GO:0048523; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;single-multicellular organism process;signal transduction by protein phosphorylation;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;MAPK cascade;negative regulation of biological process;generation of neurons;regulation of macromolecule metabolic process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;epithelial cell migration;regulation of epithelial cell migration;cell motility;protein metabolic process;negative regulation of epithelial cell migration;negative regulation of cell communication;negative regulation of metabolic process;movement of cell or subcellular component;localization of cell;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;cell migration;negative regulation of MAPK cascade;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;regulation of multicellular organismal process;negative regulation of intracellular signal transduction;negative regulation of protein modification process;regulation of intracellular signal transduction;regulation of phosphorus metabolic process;regulation of ERK1 and ERK2 cascade;regulation of cell motility;negative regulation of cell motility;negative regulation of phosphorus metabolic process;metabolic process;dephosphorylation;phosphorylation;cell differentiation;embryo development;embryo development ending in birth or egg hatching;signaling;ERBB signaling pathway;regulation of signaling;ameboidal-type cell migration;regulation of cell communication;single-organism process;regulation of MAPK cascade;negative regulation of protein metabolic process;in utero embryonic development;negative regulation of multicellular organismal process;regulation of protein metabolic process;regulation of protein modification process;chordate embryonic development;developmental process;multicellular organismal process;cellular process;negative regulation of cellular component movement;negative regulation of protein phosphorylation;regulation of locomotion;ERBB2 signaling pathway;regulation of localization;epithelium migration;tissue migration;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;macromolecule metabolic process;system development;negative regulation of ERK1 and ERK2 cascade;response to stimulus;ERK1 and ERK2 cascade;negative regulation of cellular metabolic process;regulation of cellular metabolic process;multicellular organism development;organic substance metabolic process;negative regulation of cell migration;protein phosphorylation;regulation of cell migration;neuron differentiation;negative regulation of phosphate metabolic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell communication;neurogenesis;localization;locomotion;primary metabolic process;negative regulation of locomotion;regulation of cellular component movement;nervous system development;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;negative regulation of signaling;negative regulation of cellular process; 6;4;3;7;3;3;4;5;6;7;3;4;3;4;4;4;4;5;2;7;4;7;3;7;6;4;3;4;4;4;3;4;3;5;2;5;4;2;4;6;3;3;5;5;1;3;5;6;5;5;7;4;4;5;2;6;6;5;5;6;2;8;3;5;4;2;6;5;8;3;5;6;7;2;2;2;4;7;3;9;3;5;4;5;5;4;4;7;2;6;4;4;4;3;5;7;5;6;6;6;3;3;4;6;2;2;3;3;4;5;3;3;5;4;7;3;3; GO:0016021;GO:0016020;GO:0030054;GO:0044424;GO:0044425;GO:0044421;GO:0005622;GO:0031224;GO:0048471;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0071944;GO:0005615;GO:0005886;GO:0005575;GO:0005576; integral component of membrane;membrane;cell junction;intracellular part;membrane part;extracellular region part;intracellular;intrinsic component of membrane;perinuclear region of cytoplasm;cytoplasmic part;cytoplasm;cell part;cell;cell periphery;extracellular space;plasma membrane;cellular_component;extracellular region; 4;2;2;3;2;2;3;3;5;4;4;2;2;3;3;3;1;2; GO:0060089;GO:0019901;GO:0019900;GO:0099600;GO:0003674;GO:0005488;GO:0016787;GO:0016788;GO:0003824;GO:0004725;GO:0004721;GO:0005001;GO:0016791;GO:0019899;GO:0042578;GO:0005515;GO:0038023;GO:0004872;GO:0004871;GO:0004888;GO:0019198; molecular transducer activity;protein kinase binding;kinase binding;transmembrane receptor activity;molecular_function;binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;protein tyrosine phosphatase activity;phosphoprotein phosphatase activity;transmembrane receptor protein tyrosine phosphatase activity;phosphatase activity;enzyme binding;phosphoric ester hydrolase activity;protein binding;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity;transmembrane receptor protein phosphatase activity; 2;6;5;4;1;2;3;4;2;8;7;6;6;4;5;3;3;3;2;4;5; K04458 map04010; MAPK signaling pathway; IPR016130;IPR008356;IPR016334;IPR003595;IPR029021;IPR000387;IPR000242; Protein-tyrosine phosphatase, active site;Protein-tyrosine phosphatase, KIM-containing;Protein-tyrosine phosphatase, receptor type R/non-receptor type 5;Protein-tyrosine phosphatase, catalytic;Protein-tyrosine phosphatase-like;Tyrosine specific protein phosphatases domain;PTP type protein phosphatase; extracellular Hs4506325 1363.0 T [T] Signal transduction mechanisms; P14136 Glial fibrillary acidic protein OS=Homo sapiens OX=9606 GN=GFAP PE=1 SV=1 - [GFAP_HUMAN] 1.129 0.997 0.859 1.268 1.155 0.956 1.132397192 0.992331856 1.097835498 0.44261013 0.861584754 0.163995245 0.827705628 0.071001622 GO:0080090;GO:0019222;GO:0051049;GO:0048468;GO:0001504;GO:0001505;GO:0031345;GO:0044707;GO:0071840;GO:0051716;GO:0048869;GO:0009611;GO:0045665;GO:0045664;GO:0010720;GO:0010721;GO:0048518;GO:0048519;GO:0042127;GO:0031102;GO:0060255;GO:0043062;GO:0060252;GO:0010977;GO:0010975;GO:0006836;GO:0051128;GO:0044700;GO:0045109;GO:0019538;GO:0045103;GO:0045104;GO:0098916;GO:0033554;GO:0009894;GO:0022607;GO:0021782;GO:0051580;GO:0031175;GO:0051588;GO:0050789;GO:0010625;GO:0010624;GO:0014015;GO:0014010;GO:0014013;GO:0016043;GO:0031344;GO:0065003;GO:0065007;GO:0065008;GO:0042063;GO:0050793;GO:0006810;GO:0048708;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0014002;GO:0043254;GO:0051234;GO:0050896;GO:0014009;GO:0051962;GO:0051960;GO:0099536;GO:0099537;GO:1904714;GO:0051239;GO:0070271;GO:0050803;GO:0031099;GO:0030154;GO:0050806;GO:0051129;GO:0050804;GO:0044248;GO:0023052;GO:0060284;GO:0010001;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0007417;GO:0050767;GO:0051240;GO:0051241;GO:0051246;GO:0050768;GO:0050769;GO:0030030;GO:0032502;GO:0032501;GO:0023056;GO:0008283;GO:0009987;GO:0045597;GO:0045596;GO:0045595;GO:0032879;GO:0051093;GO:0051094;GO:0060291;GO:0048167;GO:0043170;GO:0048731;GO:0008284;GO:0061684;GO:0031329;GO:0043933;GO:0031323;GO:0060020;GO:0007275;GO:0071822;GO:0051961;GO:0071704;GO:0030198;GO:0010506;GO:0048666;GO:0030182;GO:0060251;GO:0006914;GO:0006461;GO:0044767;GO:0044765;GO:0044763;GO:0007268;GO:0007267;GO:0007154;GO:0022008;GO:0009056;GO:0051179;GO:1902578;GO:0006996;GO:0044238;GO:0048699;GO:0007010;GO:0007399;GO:0048856;GO:0044237;GO:0044087;GO:1902589;GO:0044085;GO:2000026;GO:0098657;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;regulation of transport;cell development;neurotransmitter uptake;regulation of neurotransmitter levels;negative regulation of cell projection organization;single-multicellular organism process;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;response to wounding;negative regulation of neuron differentiation;regulation of neuron differentiation;positive regulation of cell development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;neuron projection regeneration;regulation of macromolecule metabolic process;extracellular structure organization;positive regulation of glial cell proliferation;negative regulation of neuron projection development;regulation of neuron projection development;neurotransmitter transport;regulation of cellular component organization;single organism signaling;intermediate filament organization;protein metabolic process;intermediate filament-based process;intermediate filament cytoskeleton organization;anterograde trans-synaptic signaling;cellular response to stress;regulation of catabolic process;cellular component assembly;glial cell development;regulation of neurotransmitter uptake;neuron projection development;regulation of neurotransmitter transport;regulation of biological process;positive regulation of Schwann cell proliferation;regulation of Schwann cell proliferation;positive regulation of gliogenesis;Schwann cell proliferation;regulation of gliogenesis;cellular component organization;regulation of cell projection organization;macromolecular complex assembly;biological regulation;regulation of biological quality;gliogenesis;regulation of developmental process;transport;astrocyte differentiation;regulation of cellular process;response to stress;biological_process;metabolic process;astrocyte development;regulation of protein complex assembly;establishment of localization;response to stimulus;glial cell proliferation;positive regulation of nervous system development;regulation of nervous system development;synaptic signaling;trans-synaptic signaling;regulation of chaperone-mediated autophagy;regulation of multicellular organismal process;protein complex biogenesis;regulation of synapse structure or activity;regeneration;cell differentiation;positive regulation of synaptic transmission;negative regulation of cellular component organization;modulation of synaptic transmission;cellular catabolic process;signaling;regulation of cell development;glial cell differentiation;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;central nervous system development;regulation of neurogenesis;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;negative regulation of neurogenesis;positive regulation of neurogenesis;cell projection organization;developmental process;multicellular organismal process;positive regulation of signaling;cell proliferation;cellular process;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;regulation of localization;negative regulation of developmental process;positive regulation of developmental process;long-term synaptic potentiation;regulation of synaptic plasticity;macromolecule metabolic process;system development;positive regulation of cell proliferation;chaperone-mediated autophagy;regulation of cellular catabolic process;macromolecular complex subunit organization;regulation of cellular metabolic process;Bergmann glial cell differentiation;multicellular organism development;protein complex subunit organization;negative regulation of nervous system development;organic substance metabolic process;extracellular matrix organization;regulation of autophagy;neuron development;neuron differentiation;regulation of glial cell proliferation;autophagy;protein complex assembly;single-organism developmental process;single-organism transport;single-organism cellular process;synaptic transmission;cell-cell signaling;cell communication;neurogenesis;catabolic process;localization;single-organism localization;organelle organization;primary metabolic process;generation of neurons;cytoskeleton organization;nervous system development;anatomical structure development;cellular metabolic process;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;regulation of multicellular organismal development;import into cell;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;4;5;4;5;3;2;3;4;4;6;7;5;5;2;2;4;5;4;4;5;6;6;5;4;3;6;4;4;5;7;4;4;4;5;5;5;5;2;6;6;6;5;7;3;5;5;2;3;7;3;4;6;3;3;1;2;6;4;3;2;4;4;5;5;6;5;3;4;4;4;5;4;4;4;4;2;5;6;3;4;4;2;5;6;3;3;5;5;5;4;2;2;3;3;2;4;4;4;3;3;3;5;5;4;4;4;4;5;4;4;7;4;5;4;3;5;4;5;6;5;3;5;3;4;3;8;4;4;6;3;2;3;4;3;7;5;5;3;3;3;4;3;4;5;3;3; GO:0099512;GO:0099513;GO:0042995;GO:0043209;GO:0016020;GO:0044297;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0005856;GO:0045111;GO:0044430;GO:0097386;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0097449;GO:0043226;GO:0097450;GO:0005882;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;cell projection;myelin sheath;membrane;cell body;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;cytoskeleton;intermediate filament cytoskeleton;cytoskeletal part;glial cell projection;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;astrocyte projection;organelle;astrocyte end-foot;intermediate filament;cellular_component; 2;3;3;3;2;3;4;5;3;2;3;3;3;5;6;4;4;3;4;4;2;2;5;2;6;4;1; GO:0005198;GO:0003674;GO:0005200; structural molecule activity;molecular_function;structural constituent of cytoskeleton; 2;1;3; K05640 map04630; Jak-STAT signaling pathway; IPR001664;IPR027701;IPR018039;IPR006821; Intermediate filament protein;Glial fibrillary acidic protein;Intermediate filament protein, conserved site;Intermediate filament head, DNA-binding domain; mitochondria P42702 Leukemia inhibitory factor receptor OS=Homo sapiens OX=9606 GN=LIFR PE=1 SV=1 - [LIFR_HUMAN] 0.904 0.894 1.162 0.969 1.124 1.359 1.011185682 nan 0.862099644 nan 1.299776286 nan 1.209074733 nan GO:0019221;GO:0038165;GO:0048468;GO:0007165;GO:0007166;GO:0007167;GO:0032989;GO:0071840;GO:0048861;GO:0051716;GO:0048869;GO:0043067;GO:0048513;GO:0048518;GO:0048519;GO:0042127;GO:0060548;GO:0010033;GO:0044700;GO:0044707;GO:0014070;GO:0031175;GO:0050789;GO:0000902;GO:0016043;GO:0065007;GO:0034097;GO:0050794;GO:0012501;GO:0008150;GO:0010656;GO:0010657;GO:0071345;GO:0050896;GO:0048812;GO:0030154;GO:0023052;GO:0070887;GO:0042221;GO:0009653;GO:0044699;GO:0031099;GO:0008284;GO:0032501;GO:0008283;GO:0009987;GO:0032990;GO:0048731;GO:0032502;GO:0030030;GO:0010660;GO:0008219;GO:0010941;GO:0007275;GO:0042981;GO:0031100;GO:0071310;GO:0043066;GO:0043069;GO:0048666;GO:0030182;GO:0070120;GO:0006915;GO:0044767;GO:0044763;GO:0007154;GO:0022008;GO:0048699;GO:0048858;GO:0007399;GO:0048856;GO:0048523;GO:0048522; cytokine-mediated signaling pathway;oncostatin-M-mediated signaling pathway;cell development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;cellular component morphogenesis;cellular component organization or biogenesis;leukemia inhibitory factor signaling pathway;cellular response to stimulus;cellular developmental process;regulation of programmed cell death;animal organ development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;negative regulation of cell death;response to organic substance;single organism signaling;single-multicellular organism process;response to organic cyclic compound;neuron projection development;regulation of biological process;cell morphogenesis;cellular component organization;biological regulation;response to cytokine;regulation of cellular process;programmed cell death;biological_process;negative regulation of muscle cell apoptotic process;muscle cell apoptotic process;cellular response to cytokine stimulus;response to stimulus;neuron projection morphogenesis;cell differentiation;signaling;cellular response to chemical stimulus;response to chemical;anatomical structure morphogenesis;single-organism process;regeneration;positive regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;cell part morphogenesis;system development;developmental process;cell projection organization;regulation of muscle cell apoptotic process;cell death;regulation of cell death;multicellular organism development;regulation of apoptotic process;organ regeneration;cellular response to organic substance;negative regulation of apoptotic process;negative regulation of programmed cell death;neuron development;neuron differentiation;ciliary neurotrophic factor-mediated signaling pathway;apoptotic process;single-organism developmental process;single-organism cellular process;cell communication;neurogenesis;generation of neurons;cell projection morphogenesis;nervous system development;anatomical structure development;negative regulation of cellular process;positive regulation of cellular process; 6;7;4;4;5;6;4;2;7;3;4;5;4;2;2;4;4;4;3;3;5;5;2;5;3;2;5;3;5;1;7;7;6;2;6;5;2;4;3;3;2;4;4;2;3;2;5;4;2;4;7;4;4;4;6;5;5;6;5;5;6;7;6;3;3;4;6;7;5;5;3;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0043235;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0031224;GO:0031226;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;receptor complex;protein complex;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;intrinsic component of membrane;intrinsic component of plasma membrane;plasma membrane part;cell part;cell;cell periphery;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 4;4;2;4;3;3;2;2;3;3;4;3;2;2;3;4;2;4;3;3;2;1;2; GO:0060089;GO:0004897;GO:0004896;GO:0099600;GO:0005126;GO:0005127;GO:0003674;GO:0005488;GO:0019838;GO:0004923;GO:0005515;GO:0005102;GO:0038023;GO:0004872;GO:0004871;GO:0004888; molecular transducer activity;ciliary neurotrophic factor receptor activity;cytokine receptor activity;transmembrane receptor activity;cytokine receptor binding;ciliary neurotrophic factor receptor binding;molecular_function;binding;growth factor binding;leukemia inhibitory factor receptor activity;protein binding;receptor binding;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity; 2;6;5;4;5;6;1;2;4;7;3;4;3;3;2;4; K05058 map04060;map04550;map04630; Cytokine-cytokine receptor interaction;Signaling pathways regulating pluripotency of stem cells;Jak-STAT signaling pathway; IPR003961;IPR013783;IPR003529; Fibronectin type III;Immunoglobulin-like fold;Long hematopoietin receptor, Gp130 family 2, conserved site; plasma membrane P00747 Plasminogen OS=Homo sapiens OX=9606 GN=PLG PE=1 SV=2 - [PLMN_HUMAN] 1.023 0.955 1.052 1.009 0.989 1.073 1.071204188 1.44E-08 1.020222447 1.42E-05 1.101570681 1.51E-18 1.084934277 2.51E-10 GO:0007599;GO:0048585;GO:0007596;GO:0048583;GO:0048771;GO:0007162;GO:0016043;GO:0071840;GO:0009611;GO:0048518;GO:0048519;GO:0042127;GO:0031589;GO:0048584;GO:0030168;GO:0016192;GO:0044707;GO:0019538;GO:0030198;GO:0030194;GO:0050820;GO:0043170;GO:0044267;GO:0044260;GO:0006887;GO:0045055;GO:1900046;GO:1900047;GO:0065007;GO:0065008;GO:1900048;GO:0098602;GO:0098609;GO:0006810;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0051234;GO:0050818;GO:0050819;GO:0046903;GO:0050896;GO:0001775;GO:0030195;GO:0022411;GO:0032102;GO:0032103;GO:0032101;GO:0030193;GO:0030155;GO:0044699;GO:0051240;GO:0051241;GO:0051917;GO:0022610;GO:0022617;GO:1903035;GO:1903036;GO:0051919;GO:0008285;GO:0032501;GO:0050878;GO:0008283;GO:0009987;GO:0042730;GO:2000047;GO:2000048;GO:1903034;GO:0032940;GO:0051239;GO:0051918;GO:0080134;GO:0016337;GO:0022407;GO:0061041;GO:0061045;GO:0090303;GO:0022408;GO:0002576;GO:0050789;GO:0071704;GO:0043062;GO:0009605;GO:0010810;GO:0010812;GO:0044765;GO:0044763;GO:0007155;GO:0044331;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0048523; hemostasis;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;tissue remodeling;negative regulation of cell adhesion;cellular component organization;cellular component organization or biogenesis;response to wounding;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;positive regulation of response to stimulus;platelet activation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;extracellular matrix organization;positive regulation of blood coagulation;positive regulation of coagulation;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;exocytosis;regulated exocytosis;regulation of hemostasis;negative regulation of hemostasis;biological regulation;regulation of biological quality;positive regulation of hemostasis;single organism cell adhesion;cell-cell adhesion;transport;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;establishment of localization;regulation of coagulation;negative regulation of coagulation;secretion;response to stimulus;cell activation;negative regulation of blood coagulation;cellular component disassembly;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;regulation of blood coagulation;regulation of cell adhesion;single-organism process;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of fibrinolysis;biological adhesion;extracellular matrix disassembly;negative regulation of response to wounding;positive regulation of response to wounding;positive regulation of fibrinolysis;negative regulation of cell proliferation;multicellular organismal process;regulation of body fluid levels;cell proliferation;cellular process;fibrinolysis;regulation of cell-cell adhesion mediated by cadherin;negative regulation of cell-cell adhesion mediated by cadherin;regulation of response to wounding;secretion by cell;regulation of multicellular organismal process;negative regulation of fibrinolysis;regulation of response to stress;single organismal cell-cell adhesion;regulation of cell-cell adhesion;regulation of wound healing;negative regulation of wound healing;positive regulation of wound healing;negative regulation of cell-cell adhesion;platelet degranulation;regulation of biological process;organic substance metabolic process;extracellular structure organization;response to external stimulus;regulation of cell-substrate adhesion;negative regulation of cell-substrate adhesion;single-organism transport;single-organism cellular process;cell adhesion;cell-cell adhesion mediated by cadherin;localization;single-organism localization;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 5;3;5;3;4;4;3;2;4;2;2;4;4;3;5;5;3;4;5;5;4;4;5;4;5;6;4;4;2;3;4;3;4;4;5;3;3;4;1;2;3;4;4;5;2;4;5;4;4;4;4;5;4;2;3;3;6;2;5;4;4;3;4;2;4;3;2;6;6;6;5;4;3;3;4;4;5;6;5;5;5;7;2;3;4;3;5;5;4;3;3;5;2;3;3;3;3; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0099503;GO:0034774;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0043229;GO:0043227;GO:0043226;GO:0072562;GO:0044433;GO:0044459;GO:0030141;GO:0097708;GO:0044446;GO:0044444;GO:0012505;GO:0019897;GO:0019898;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0009986;GO:0031232;GO:0044464;GO:0005623;GO:0005622;GO:0098552;GO:0071944;GO:0005615;GO:0005886;GO:1903561;GO:0070062;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;secretory vesicle;secretory granule lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;intracellular organelle;membrane-bounded organelle;organelle;blood microparticle;cytoplasmic vesicle part;plasma membrane part;secretory granule;intracellular vesicle;intracellular organelle part;cytoplasmic part;endomembrane system;extrinsic component of plasma membrane;extrinsic component of membrane;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell surface;extrinsic component of external side of plasma membrane;cell part;cell;intracellular;side of membrane;cell periphery;extracellular space;plasma membrane;extracellular vesicle;extracellular exosome;cellular_component;extracellular region; 2;4;4;5;2;5;6;5;3;4;3;3;2;2;2;4;3;3;2;3;4;3;4;4;3;4;3;4;3;5;4;5;6;5;3;5;2;2;3;3;3;3;3;3;4;1;2; GO:0004252;GO:0017171;GO:0019904;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0034185;GO:0005515;GO:0005102;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;protein domain specific binding;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;apolipoprotein binding;protein binding;receptor binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;4;1;2;3;2;4;5;4;3;4;6;5; K01315 map04080;map04610;map05150;map05164; Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Staphylococcus aureus infection;Influenza A; IPR003609;IPR001254;IPR018056;IPR023317;IPR009003;IPR000001;IPR001314;IPR013806;IPR033116;IPR018114; PAN/Apple domain;Serine proteases, trypsin domain;Kringle, conserved site;Peptidase S1A, plasmin;Peptidase S1, PA clan;Kringle;Peptidase S1A, chymotrypsin family;Kringle-like fold;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular 159897046 174.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease P00746 Complement factor D OS=Homo sapiens OX=9606 GN=CFD PE=1 SV=5 - [CFAD_HUMAN] 1.076 0.992 0.929 1.068 0.964 1.156 1.084677419 0.07429395 1.107883817 0.283593868 0.936491935 0.748472114 1.199170124 0.010776067 GO:0007599;GO:0007596;GO:0048583;GO:0044710;GO:0009611;GO:0048518;GO:0065007;GO:0048584;GO:0030168;GO:0016192;GO:0044707;GO:0019538;GO:0002376;GO:0050789;GO:0006887;GO:0045055;GO:0002684;GO:0002682;GO:0065008;GO:0006810;GO:0042060;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0006955;GO:0006959;GO:0046903;GO:0050896;GO:0001775;GO:0006956;GO:0006957;GO:0044699;GO:0051234;GO:0006508;GO:0032501;GO:0050878;GO:0009987;GO:0050776;GO:0050778;GO:0043170;GO:0072376;GO:0002576;GO:0032940;GO:0071704;GO:0045087;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0044238;GO:0002253;GO:0002252; hemostasis;blood coagulation;regulation of response to stimulus;single-organism metabolic process;response to wounding;positive regulation of biological process;biological regulation;positive regulation of response to stimulus;platelet activation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;immune system process;regulation of biological process;exocytosis;regulated exocytosis;positive regulation of immune system process;regulation of immune system process;regulation of biological quality;transport;wound healing;defense response;response to stress;coagulation;biological_process;metabolic process;immune response;humoral immune response;secretion;response to stimulus;cell activation;complement activation;complement activation, alternative pathway;single-organism process;establishment of localization;proteolysis;multicellular organismal process;regulation of body fluid levels;cellular process;regulation of immune response;positive regulation of immune response;macromolecule metabolic process;protein activation cascade;platelet degranulation;secretion by cell;organic substance metabolic process;innate immune response;single-organism transport;single-organism cellular process;localization;single-organism localization;primary metabolic process;activation of immune response;immune effector process; 5;5;3;3;4;2;2;3;5;5;3;4;2;2;5;6;3;3;3;4;5;4;3;4;1;2;3;4;5;2;4;4;5;2;3;5;2;4;2;4;4;4;3;7;4;3;4;4;3;2;3;3;3;3; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0099503;GO:0034774;GO:0043231;GO:0043230;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044433;GO:0030141;GO:0097708;GO:0044446;GO:0044444;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0012505;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;secretory vesicle;secretory granule lumen;intracellular membrane-bounded organelle;extracellular organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasmic vesicle part;secretory granule;intracellular vesicle;intracellular organelle part;cytoplasmic part;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;endomembrane system;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 2;4;4;5;5;6;5;4;3;3;3;2;2;3;3;3;4;4;4;3;4;5;4;5;6;5;2;2;3;4;2;3;3;1;2; GO:0004252;GO:0017171;GO:0003674;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;molecular_function;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;1;3;2;4;5;6;5; K01334 map04610;map05150; Complement and coagulation cascades;Staphylococcus aureus infection; IPR001254;IPR009003;IPR033116;IPR001314;IPR018114; Serine proteases, trypsin domain;Peptidase S1, PA clan;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family;Serine proteases, trypsin family, histidine active site; extracellular Hs18590905 457.0 E [E] Amino acid transport and metabolism; P00740 Coagulation factor IX OS=Homo sapiens OX=9606 GN=F9 PE=1 SV=2 - [FA9_HUMAN] 0.926 0.942 1.142 0.994 0.909 1.695 0.983014862 0.568966618 1.093509351 0.292687857 1.212314225 0.003720153 1.864686469 0.001502063 GO:0007599;GO:0007598;GO:0007597;GO:0007596;GO:0044710;GO:0018214;GO:0009611;GO:0018193;GO:0016192;GO:1901564;GO:0044707;GO:0019538;GO:0017187;GO:0018200;GO:0006807;GO:0044267;GO:0006888;GO:0044260;GO:0065007;GO:0065008;GO:0006810;GO:0042060;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0051604;GO:0050896;GO:0006950;GO:0050817;GO:0006518;GO:0051649;GO:0034641;GO:0044699;GO:0006508;GO:0032501;GO:0050878;GO:0043687;GO:0009987;GO:0016485;GO:0046907;GO:0043603;GO:0043170;GO:0072376;GO:0072378;GO:0031638;GO:0071704;GO:0010467;GO:0048193;GO:0006464;GO:0006465;GO:0044765;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0044237;GO:1902582; hemostasis;blood coagulation, extrinsic pathway;blood coagulation, intrinsic pathway;blood coagulation;single-organism metabolic process;protein carboxylation;response to wounding;peptidyl-amino acid modification;vesicle-mediated transport;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;peptidyl-glutamic acid carboxylation;peptidyl-glutamic acid modification;nitrogen compound metabolic process;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;biological regulation;regulation of biological quality;transport;wound healing;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;protein maturation;response to stimulus;response to stress;coagulation;peptide metabolic process;establishment of localization in cell;cellular nitrogen compound metabolic process;single-organism process;proteolysis;multicellular organismal process;regulation of body fluid levels;post-translational protein modification;cellular process;protein processing;intracellular transport;cellular amide metabolic process;macromolecule metabolic process;protein activation cascade;blood coagulation, fibrin clot formation;zymogen activation;organic substance metabolic process;gene expression;Golgi vesicle transport;cellular protein modification process;signal peptide processing;single-organism transport;localization;single-organism localization;cellular localization;primary metabolic process;cellular metabolic process;single-organism intracellular transport; 5;4;4;5;3;7;4;7;5;4;3;4;8;8;3;5;7;4;2;3;4;5;5;5;1;2;3;5;2;3;4;5;4;4;2;5;2;4;7;2;6;5;5;4;3;4;7;3;5;6;6;6;4;2;3;3;3;3;5; GO:0031974;GO:0005783;GO:0031982;GO:0005615;GO:0016020;GO:0005794;GO:0005796;GO:0005788;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0005886;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;endoplasmic reticulum;vesicle;extracellular space;membrane;Golgi apparatus;Golgi lumen;endoplasmic reticulum lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;cell periphery;extracellular exosome;plasma membrane;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;4;3;2;4;5;5;3;4;3;3;2;2;3;3;3;2;4;4;3;3;4;4;2;2;3;4;3;3;1;4;2; GO:0004252;GO:0046872;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0005509;GO:0004175;GO:0070011; serine-type endopeptidase activity;metal ion binding;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;cation binding;ion binding;calcium ion binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;5;4;1;2;3;2;4;5;4;3;6;6;5; K01321 map04610; Complement and coagulation cascades; IPR000152;IPR018097;IPR001254;IPR000742;IPR017857;IPR009003;IPR000294;IPR001314;IPR001881;IPR013032;IPR035694;IPR033116;IPR018114; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;EGF-like domain;Coagulation factor, subgroup, Gla domain;Peptidase S1, PA clan;Gamma-carboxyglutamic acid-rich (GLA) domain;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;EGF-like, conserved site;Coagulation factor IX;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular 159897046 198.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease P00742 Coagulation factor X OS=Homo sapiens OX=9606 GN=F10 PE=1 SV=2 - [FA10_HUMAN] 1.023 0.956 1.168 1.024 0.9 1.161 1.070083682 0.468286232 1.137777778 0.002199678 1.221757322 0.009763133 1.29 0.002517358 GO:0007599;GO:0007598;GO:0007597;GO:0007596;GO:0048583;GO:0007165;GO:0051897;GO:0051896;GO:0044710;GO:0009966;GO:0009967;GO:0018214;GO:0009611;GO:0018193;GO:0048518;GO:0044700;GO:0065008;GO:1901564;GO:0016192;GO:0044707;GO:0048870;GO:0019538;GO:0017187;GO:0018200;GO:0010647;GO:0006928;GO:0051674;GO:0035556;GO:0050789;GO:0044267;GO:0006888;GO:0044260;GO:0065007;GO:0016477;GO:0006810;GO:0051716;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:1902533;GO:0051234;GO:0046907;GO:0043491;GO:0050896;GO:0043412;GO:0036211;GO:2000145;GO:2000147;GO:0006518;GO:0023056;GO:0034641;GO:0023052;GO:0023051;GO:0010646;GO:0044699;GO:1902531;GO:0048584;GO:0006508;GO:0032501;GO:0050878;GO:0051272;GO:0009987;GO:0051270;GO:0016485;GO:0032879;GO:0051604;GO:0043603;GO:0043170;GO:0006807;GO:0072376;GO:0072378;GO:0071704;GO:0010467;GO:0043687;GO:0030335;GO:0030334;GO:0048193;GO:0006464;GO:0006465;GO:0044765;GO:0044763;GO:0051649;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0040012;GO:0040017;GO:0044237;GO:1902582;GO:0048522; hemostasis;blood coagulation, extrinsic pathway;blood coagulation, intrinsic pathway;blood coagulation;regulation of response to stimulus;signal transduction;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;single-organism metabolic process;regulation of signal transduction;positive regulation of signal transduction;protein carboxylation;response to wounding;peptidyl-amino acid modification;positive regulation of biological process;single organism signaling;regulation of biological quality;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;cell motility;protein metabolic process;peptidyl-glutamic acid carboxylation;peptidyl-glutamic acid modification;positive regulation of cell communication;movement of cell or subcellular component;localization of cell;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;biological regulation;cell migration;transport;cellular response to stimulus;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;positive regulation of intracellular signal transduction;establishment of localization;intracellular transport;protein kinase B signaling;response to stimulus;macromolecule modification;protein modification process;regulation of cell motility;positive regulation of cell motility;peptide metabolic process;positive regulation of signaling;cellular nitrogen compound metabolic process;signaling;regulation of signaling;regulation of cell communication;single-organism process;regulation of intracellular signal transduction;positive regulation of response to stimulus;proteolysis;multicellular organismal process;regulation of body fluid levels;positive regulation of cellular component movement;cellular process;regulation of cellular component movement;protein processing;regulation of localization;protein maturation;cellular amide metabolic process;macromolecule metabolic process;nitrogen compound metabolic process;protein activation cascade;blood coagulation, fibrin clot formation;organic substance metabolic process;gene expression;post-translational protein modification;positive regulation of cell migration;regulation of cell migration;Golgi vesicle transport;cellular protein modification process;signal peptide processing;single-organism transport;single-organism cellular process;establishment of localization in cell;cell communication;localization;single-organism localization;cellular localization;locomotion;primary metabolic process;regulation of locomotion;positive regulation of locomotion;cellular metabolic process;single-organism intracellular transport;positive regulation of cellular process; 5;4;4;5;3;4;6;6;3;4;4;7;4;7;2;3;3;4;5;3;3;4;8;8;4;4;3;5;2;5;7;4;2;4;4;3;5;3;3;4;1;2;5;3;5;6;2;5;5;4;4;5;3;4;2;3;4;2;5;3;5;2;4;4;2;4;6;3;5;5;4;3;3;4;3;5;7;5;5;6;6;6;4;3;4;4;2;3;3;2;3;3;3;3;5;3; GO:0031974;GO:0005783;GO:0005794;GO:0005796;GO:0005788;GO:0043231;GO:0043233;GO:0044424;GO:0044425;GO:0044422;GO:0009897;GO:0043229;GO:0005622;GO:0043227;GO:0044432;GO:0044431;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0016020;GO:0005886;GO:0031226;GO:0005737;GO:0044459;GO:0009986;GO:0031233;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0043226;GO:0005576;GO:0005575;GO:0070013; membrane-enclosed lumen;endoplasmic reticulum;Golgi apparatus;Golgi lumen;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;membrane part;organelle part;external side of plasma membrane;intracellular organelle;intracellular;membrane-bounded organelle;endoplasmic reticulum part;Golgi apparatus part;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;membrane;plasma membrane;intrinsic component of plasma membrane;cytoplasm;plasma membrane part;cell surface;intrinsic component of external side of plasma membrane;cell part;cell;cell periphery;side of membrane;organelle;extracellular region;cellular_component;intracellular organelle lumen; 2;4;4;5;5;4;3;3;2;2;4;3;3;3;4;4;3;3;3;4;2;3;4;4;3;3;5;2;2;3;3;2;2;1;4; GO:0004252;GO:0005543;GO:0046872;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0005509;GO:0008289;GO:0004175;GO:0043168;GO:0070011; serine-type endopeptidase activity;phospholipid binding;metal ion binding;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;cation binding;ion binding;calcium ion binding;lipid binding;endopeptidase activity;anion binding;peptidase activity, acting on L-amino acid peptides; 6;4;5;4;1;2;3;2;4;5;4;3;6;3;6;4;5; K01314 map04610; Complement and coagulation cascades; IPR000152;IPR018097;IPR001254;IPR000742;IPR017857;IPR009003;IPR000294;IPR001314;IPR001881;IPR013032;IPR033116;IPR035627;IPR018114; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;EGF-like domain;Coagulation factor, subgroup, Gla domain;Peptidase S1, PA clan;Gamma-carboxyglutamic acid-rich (GLA) domain;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Coagulation factor X;Serine proteases, trypsin family, histidine active site; extracellular 159897046 176.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease Q9ULD5 Zinc finger protein 777 OS=Homo sapiens OX=9606 GN=ZNF777 PE=1 SV=2 - [ZN777_HUMAN] 0.905 1.024 1.13 1.026 1.173 0.721 0.883789063 nan 0.874680307 nan 1.103515625 nan 0.614663257 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; K09228 IPR013087;IPR013083;IPR022137;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Protein of unknown function DUF3669, zinc finger protein;Krueppel-associated box; nucleus Hs22047655 654.0 R [R] General function prediction only; P09172 Dopamine beta-hydroxylase OS=Homo sapiens OX=9606 GN=DBH PE=1 SV=3 - [DOPO_HUMAN] 0.815 0.612 2.052 0.8 0.464 1.673 1.331699346 nan 1.724137931 nan 3.352941176 nan 3.605603448 nan GO:2001236;GO:0045907;GO:2001233;GO:0048583;GO:0019229;GO:0007610;GO:0007611;GO:0003013;GO:0007165;GO:0007166;GO:0001659;GO:0003018;GO:1901362;GO:1901360;GO:1901361;GO:0051716;GO:1901565;GO:0009966;GO:0048518;GO:0042127;GO:0019336;GO:0007612;GO:0007613;GO:0010033;GO:0003008;GO:0044700;GO:0016477;GO:1901564;GO:1901566;GO:0044707;GO:0044708;GO:0010243;GO:0048870;GO:0048878;GO:0002376;GO:0007154;GO:0098916;GO:0033555;GO:0019439;GO:0019438;GO:0044281;GO:0007632;GO:0007626;GO:0006928;GO:0006807;GO:0042310;GO:0042424;GO:0042981;GO:0050789;GO:0042420;GO:0042421;GO:1901576;GO:1901575;GO:0014075;GO:0097164;GO:0019098;GO:0090066;GO:0065007;GO:0065008;GO:0035150;GO:0008015;GO:0044710;GO:0050794;GO:0012501;GO:1903524;GO:0008306;GO:1903522;GO:0008152;GO:0048265;GO:1901698;GO:0050890;GO:0006950;GO:0001975;GO:0008150;GO:0006584;GO:0097305;GO:0009713;GO:0099536;GO:0099537;GO:0051239;GO:0048149;GO:0009314;GO:0044248;GO:0044249;GO:0034641;GO:0023052;GO:0023051;GO:0010646;GO:0044699;GO:0009719;GO:0050880;GO:0044057;GO:0001974;GO:0051240;GO:0009712;GO:0000003;GO:0040011;GO:0032501;GO:0048609;GO:0032504;GO:0009628;GO:0050877;GO:0009987;GO:0006725;GO:0042417;GO:0042415;GO:0060746;GO:0018958;GO:0048771;GO:0042711;GO:0048871;GO:0001816;GO:0051674;GO:0042309;GO:0050896;GO:0019614;GO:0097190;GO:0097191;GO:0042592;GO:0042593;GO:0050900;GO:0042596;GO:0008219;GO:0010941;GO:0022414;GO:0008283;GO:0033500;GO:0042423;GO:0071704;GO:0043067;GO:0008542;GO:0046189;GO:0006915;GO:0045471;GO:0009058;GO:0044763;GO:0007268;GO:0007267;GO:0042221;GO:0002443;GO:0009056;GO:0051179;GO:1901700;GO:0030534;GO:0009416;GO:1901616;GO:0044237;GO:1901617;GO:0002252;GO:1901615; regulation of extrinsic apoptotic signaling pathway;positive regulation of vasoconstriction;regulation of apoptotic signaling pathway;regulation of response to stimulus;regulation of vasoconstriction;behavior;learning or memory;circulatory system process;signal transduction;cell surface receptor signaling pathway;temperature homeostasis;vascular process in circulatory system;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;cellular response to stimulus;organonitrogen compound catabolic process;regulation of signal transduction;positive regulation of biological process;regulation of cell proliferation;phenol-containing compound catabolic process;learning;memory;response to organic substance;system process;single organism signaling;cell migration;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;single-multicellular organism process;single-organism behavior;response to organonitrogen compound;cell motility;chemical homeostasis;immune system process;cell communication;anterograde trans-synaptic signaling;multicellular organismal response to stress;aromatic compound catabolic process;aromatic compound biosynthetic process;small molecule metabolic process;visual behavior;locomotory behavior;movement of cell or subcellular component;nitrogen compound metabolic process;vasoconstriction;catecholamine catabolic process;regulation of apoptotic process;regulation of biological process;dopamine catabolic process;norepinephrine biosynthetic process;organic substance biosynthetic process;organic substance catabolic process;response to amine;ammonium ion metabolic process;reproductive behavior;regulation of anatomical structure size;biological regulation;regulation of biological quality;regulation of tube size;blood circulation;single-organism metabolic process;regulation of cellular process;programmed cell death;positive regulation of blood circulation;associative learning;regulation of blood circulation;metabolic process;response to pain;response to nitrogen compound;cognition;response to stress;response to amphetamine;biological_process;catecholamine metabolic process;response to alcohol;catechol-containing compound biosynthetic process;synaptic signaling;trans-synaptic signaling;regulation of multicellular organismal process;behavioral response to ethanol;response to radiation;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of signaling;regulation of cell communication;single-organism process;response to endogenous stimulus;regulation of blood vessel size;regulation of system process;blood vessel remodeling;positive regulation of multicellular organismal process;catechol-containing compound metabolic process;reproduction;locomotion;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;response to abiotic stimulus;neurological system process;cellular process;cellular aromatic compound metabolic process;dopamine metabolic process;norepinephrine metabolic process;parental behavior;phenol-containing compound metabolic process;tissue remodeling;maternal behavior;multicellular organismal homeostasis;cytokine production;localization of cell;homoiothermy;response to stimulus;catechol-containing compound catabolic process;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;homeostatic process;glucose homeostasis;leukocyte migration;fear response;cell death;regulation of cell death;reproductive process;cell proliferation;carbohydrate homeostasis;catecholamine biosynthetic process;organic substance metabolic process;regulation of programmed cell death;visual learning;phenol-containing compound biosynthetic process;apoptotic process;response to ethanol;biosynthetic process;single-organism cellular process;synaptic transmission;cell-cell signaling;response to chemical;leukocyte mediated immunity;catabolic process;localization;response to oxygen-containing compound;adult behavior;response to light stimulus;organic hydroxy compound catabolic process;cellular metabolic process;organic hydroxy compound biosynthetic process;immune effector process;organic hydroxy compound metabolic process; 6;5;5;3;6;2;4;4;4;5;5;5;5;4;5;3;5;4;2;4;6;5;5;4;3;3;4;4;5;3;3;4;3;5;2;4;7;4;5;5;4;4;3;4;3;7;6;6;2;6;7;4;4;5;4;3;4;2;3;5;5;3;3;5;4;6;5;2;5;4;5;3;6;1;5;5;7;5;6;3;5;4;4;4;4;2;3;4;2;3;6;4;5;3;6;2;2;2;3;3;3;4;2;4;5;6;4;5;4;5;4;4;3;6;2;7;5;6;4;7;3;5;4;4;2;3;6;6;3;5;5;6;6;6;3;3;8;4;3;4;3;2;4;4;5;5;3;5;3;4; GO:0012506;GO:0031983;GO:0016021;GO:0016020;GO:0031988;GO:0099503;GO:0098588;GO:0031974;GO:0034774;GO:0043233;GO:0044422;GO:0060205;GO:0043229;GO:0034466;GO:0044433;GO:0031224;GO:0005737;GO:0030141;GO:0097708;GO:0044425;GO:0031982;GO:0016023;GO:0044444;GO:0043231;GO:0030667;GO:0031090;GO:0031410;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0012505;GO:0042583;GO:0044424;GO:0030133;GO:0044446;GO:0043227;GO:0098805;GO:0042584;GO:0030658;GO:0005575;GO:0005576;GO:0043226; vesicle membrane;vesicle lumen;integral component of membrane;membrane;membrane-bounded vesicle;secretory vesicle;bounding membrane of organelle;membrane-enclosed lumen;secretory granule lumen;organelle lumen;organelle part;cytoplasmic membrane-bounded vesicle lumen;intracellular organelle;chromaffin granule lumen;cytoplasmic vesicle part;intrinsic component of membrane;cytoplasm;secretory granule;intracellular vesicle;membrane part;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;intracellular membrane-bounded organelle;secretory granule membrane;organelle membrane;cytoplasmic vesicle;cytoplasmic vesicle membrane;cell part;cell;intracellular;endomembrane system;chromaffin granule;intracellular part;transport vesicle;intracellular organelle part;membrane-bounded organelle;whole membrane;chromaffin granule membrane;transport vesicle membrane;cellular_component;extracellular region;organelle; 4;4;4;2;5;6;4;2;5;3;2;5;3;6;4;3;4;4;4;2;4;5;4;4;4;3;5;5;2;2;3;3;5;3;4;3;3;3;5;4;1;2;2; GO:0004497;GO:0046872;GO:0016715;GO:0003674;GO:0005488;GO:0046914;GO:0043169;GO:0003824;GO:0016705;GO:0048029;GO:0043168;GO:0016491;GO:0031418;GO:0043167;GO:0005507;GO:0030246;GO:0043177;GO:0031406;GO:0019842;GO:0004500;GO:0036094; monooxygenase activity;metal ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;molecular_function;binding;transition metal ion binding;cation binding;catalytic activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;monosaccharide binding;anion binding;oxidoreductase activity;L-ascorbic acid binding;ion binding;copper ion binding;carbohydrate binding;organic acid binding;carboxylic acid binding;vitamin binding;dopamine beta-monooxygenase activity;small molecule binding; 4;5;5;1;2;6;4;2;4;4;4;3;5;3;7;3;4;5;4;6;3; K00503 map00350;map01100; Tyrosine metabolism;Metabolic pathways; IPR000945;IPR020611;IPR024548;IPR000323;IPR005018;IPR014783;IPR014784;IPR028460;IPR008977; Dopamine beta-hydroxylase-related;Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site;Copper type II ascorbate-dependent monooxygenase, C-terminal;Copper type II, ascorbate-dependent monooxygenase, N-terminal;DOMON domain;Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site;Copper type II, ascorbate-dependent monooxygenase-like, C-terminal;Tyramine beta-hydroxylase/Dopamine beta-hydroxylase;PHM/PNGase F domain; extracellular Hs18426906 1259.0 E [E] Amino acid transport and metabolism; P12259 Coagulation factor V OS=Homo sapiens OX=9606 GN=F5 PE=1 SV=4 - [FA5_HUMAN] 1.046 1.047 0.949 1.004 1.008 0.929 0.99904489 0.884226157 0.996031746 0.792076192 0.906399236 0.594385081 0.921626984 0.818059662 GO:0007599;GO:0007596;GO:0006901;GO:0006900;GO:0006903;GO:0061024;GO:0003013;GO:0006486;GO:1901576;GO:0051656;GO:0051650;GO:0071840;GO:0044710;GO:0018196;GO:0009611;GO:0018193;GO:0051668;GO:0030168;GO:0016192;GO:0044707;GO:0019538;GO:0016050;GO:0022607;GO:0006950;GO:0044267;GO:0006888;GO:0006887;GO:0016043;GO:0045055;GO:0065003;GO:0065007;GO:0065008;GO:0008015;GO:0003008;GO:0006810;GO:0042060;GO:0043412;GO:0043413;GO:0044802;GO:0008152;GO:0044723;GO:0051234;GO:0090114;GO:0046903;GO:0046907;GO:0050896;GO:0009058;GO:0036211;GO:0008150;GO:0050817;GO:0070271;GO:0001775;GO:0044249;GO:0034645;GO:0044699;GO:0051640;GO:0032501;GO:1902591;GO:0050878;GO:0043687;GO:0009987;GO:1901137;GO:1901135;GO:0032940;GO:0043170;GO:0048208;GO:0043933;GO:0048207;GO:0009100;GO:0009101;GO:0071822;GO:0006487;GO:0002576;GO:0071704;GO:0044085;GO:0018279;GO:0048193;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0044765;GO:0009059;GO:0044763;GO:0051648;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0044260;GO:0044237;GO:1902589;GO:1902582;GO:1902580; hemostasis;blood coagulation;vesicle coating;membrane budding;vesicle targeting;membrane organization;circulatory system process;protein glycosylation;organic substance biosynthetic process;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;single-organism metabolic process;peptidyl-asparagine modification;response to wounding;peptidyl-amino acid modification;localization within membrane;platelet activation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;vesicle organization;cellular component assembly;response to stress;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;exocytosis;cellular component organization;regulated exocytosis;macromolecular complex assembly;biological regulation;regulation of biological quality;blood circulation;system process;transport;wound healing;macromolecule modification;macromolecule glycosylation;single-organism membrane organization;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;COPII-coated vesicle budding;secretion;intracellular transport;response to stimulus;biosynthetic process;protein modification process;biological_process;coagulation;protein complex biogenesis;cell activation;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;organelle localization;multicellular organismal process;single-organism membrane budding;regulation of body fluid levels;post-translational protein modification;cellular process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;secretion by cell;macromolecule metabolic process;COPII vesicle coating;macromolecular complex subunit organization;vesicle targeting, rough ER to cis-Golgi;glycoprotein metabolic process;glycoprotein biosynthetic process;protein complex subunit organization;protein N-linked glycosylation;platelet degranulation;organic substance metabolic process;cellular component biogenesis;protein N-linked glycosylation via asparagine;Golgi vesicle transport;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;vesicle localization;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;cellular macromolecule metabolic process;cellular metabolic process;single-organism organelle organization;single-organism intracellular transport;single-organism cellular localization; 5;5;6;5;4;4;4;4;4;4;5;2;3;8;4;7;4;5;5;3;4;5;4;3;5;7;5;3;6;5;2;3;5;3;4;5;5;6;4;2;4;3;5;5;5;2;3;5;1;4;4;4;4;5;2;4;2;5;4;7;2;5;4;4;4;6;4;6;5;6;5;5;7;3;3;6;6;5;5;5;6;4;5;3;5;4;2;3;3;4;3;4;4;3;4;5;4; GO:0005783;GO:0044433;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0005794;GO:0099503;GO:0098588;GO:0031974;GO:0034774;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0030141;GO:0097708;GO:0000139;GO:0044446;GO:0044444;GO:0012505;GO:0016020;GO:0005788;GO:0005886;GO:0033116;GO:0060205;GO:0005737;GO:0031091;GO:0031090;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0071944;GO:0030133;GO:0005615;GO:0030135;GO:0005793;GO:0030134;GO:1903561;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;cytoplasmic vesicle part;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;Golgi apparatus;secretory vesicle;bounding membrane of organelle;membrane-enclosed lumen;secretory granule lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;secretory granule;intracellular vesicle;Golgi membrane;intracellular organelle part;cytoplasmic part;endomembrane system;membrane;endoplasmic reticulum lumen;plasma membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;organelle membrane;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;cell periphery;transport vesicle;extracellular space;coated vesicle;endoplasmic reticulum-Golgi intermediate compartment;ER to Golgi transport vesicle;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 4;4;4;4;5;5;4;6;4;2;5;3;4;3;3;2;2;3;3;3;2;4;4;4;4;5;3;4;3;2;5;3;5;5;4;5;3;6;5;2;2;3;4;3;6;5;5;3;1;4;2; GO:0046872;GO:0003674;GO:0005488;GO:0046914;GO:0043169;GO:0043167;GO:0005507; metal ion binding;molecular_function;binding;transition metal ion binding;cation binding;ion binding;copper ion binding; 5;1;2;6;4;3;7; K03902 map04610; Complement and coagulation cascades; IPR029821;IPR024715;IPR011707;IPR000421;IPR033138;IPR008979;IPR008972; Coagulation factor V;Coagulation factor 5/8-like;Multicopper oxidase, type 3;Coagulation factor 5/8 C-terminal domain;Multicopper oxidases, conserved site;Galactose-binding domain-like;Cupredoxin; extracellular 392375945 228.0 DPM [D] Cell cycle control, cell division, chromosome partitioning; [P] Inorganic ion transport and metabolism; [M] Cell wall/membrane/envelope biogenesis; COG2132 Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA) Q9UBR2 Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1 - [CATZ_HUMAN] 1.036 1.293 0.798 1.011 1.225 0.589 0.801237432 nan 0.825306122 nan 0.617169374 nan 0.480816327 nan GO:0019222;GO:0003073;GO:0051603;GO:0006901;GO:0006900;GO:0061024;GO:0003013;GO:1901576;GO:0051656;GO:0051650;GO:0071840;GO:0080090;GO:0042445;GO:0044710;GO:0018193;GO:0048513;GO:0003008;GO:0060541;GO:0060255;GO:0006903;GO:0051668;GO:0001991;GO:0001990;GO:0016192;GO:0044257;GO:1901564;GO:0044707;GO:0019538;GO:0016050;GO:0022607;GO:0009101;GO:0060177;GO:0006807;GO:0003081;GO:0044267;GO:1901575;GO:0044265;GO:0006888;GO:0044260;GO:0061138;GO:0016043;GO:0065003;GO:0065007;GO:0065008;GO:0009887;GO:0008015;GO:0006810;GO:0009888;GO:0043412;GO:0043413;GO:0044802;GO:0008152;GO:0044723;GO:0051234;GO:0050886;GO:0090114;GO:0046907;GO:0009058;GO:0036211;GO:0007275;GO:0008150;GO:0006518;GO:0044085;GO:0018196;GO:0070271;GO:0044248;GO:0044249;GO:0034641;GO:0034645;GO:0009653;GO:0044699;GO:0051246;GO:0009057;GO:0060441;GO:0051640;GO:0006508;GO:0032502;GO:0032501;GO:0035239;GO:1902591;GO:0060425;GO:0043687;GO:0009987;GO:0060562;GO:0016485;GO:0016486;GO:0003044;GO:0051604;GO:0043603;GO:1901137;GO:1901135;GO:0043170;GO:0001763;GO:0048731;GO:0048208;GO:0030323;GO:0030324;GO:0043933;GO:0048754;GO:0048207;GO:0008217;GO:0002009;GO:0071822;GO:0006487;GO:0009100;GO:0002002;GO:0002003;GO:0050789;GO:0071704;GO:0010467;GO:0048729;GO:0018279;GO:0060429;GO:0048193;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0010817;GO:0044767;GO:0044765;GO:0009059;GO:0044763;GO:0051648;GO:0051649;GO:0035295;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0006486;GO:0048856;GO:0044237;GO:1902589;GO:1902582;GO:1902580;GO:0030163; regulation of metabolic process;regulation of systemic arterial blood pressure;proteolysis involved in cellular protein catabolic process;vesicle coating;membrane budding;membrane organization;circulatory system process;organic substance biosynthetic process;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;regulation of primary metabolic process;hormone metabolic process;single-organism metabolic process;peptidyl-amino acid modification;animal organ development;system process;respiratory system development;regulation of macromolecule metabolic process;vesicle targeting;localization within membrane;regulation of systemic arterial blood pressure by circulatory renin-angiotensin;regulation of systemic arterial blood pressure by hormone;vesicle-mediated transport;cellular protein catabolic process;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;vesicle organization;cellular component assembly;glycoprotein biosynthetic process;regulation of angiotensin metabolic process;nitrogen compound metabolic process;regulation of systemic arterial blood pressure by renin-angiotensin;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;morphogenesis of a branching epithelium;cellular component organization;macromolecular complex assembly;biological regulation;regulation of biological quality;organ morphogenesis;blood circulation;transport;tissue development;macromolecule modification;macromolecule glycosylation;single-organism membrane organization;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;endocrine process;COPII-coated vesicle budding;intracellular transport;biosynthetic process;protein modification process;multicellular organism development;biological_process;peptide metabolic process;cellular component biogenesis;peptidyl-asparagine modification;protein complex biogenesis;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;regulation of protein metabolic process;macromolecule catabolic process;epithelial tube branching involved in lung morphogenesis;organelle localization;proteolysis;developmental process;multicellular organismal process;tube morphogenesis;single-organism membrane budding;lung morphogenesis;post-translational protein modification;cellular process;epithelial tube morphogenesis;protein processing;peptide hormone processing;regulation of systemic arterial blood pressure mediated by a chemical signal;protein maturation;cellular amide metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;morphogenesis of a branching structure;system development;COPII vesicle coating;respiratory tube development;lung development;macromolecular complex subunit organization;branching morphogenesis of an epithelial tube;vesicle targeting, rough ER to cis-Golgi;regulation of blood pressure;morphogenesis of an epithelium;protein complex subunit organization;protein N-linked glycosylation;glycoprotein metabolic process;regulation of angiotensin levels in blood;angiotensin maturation;regulation of biological process;organic substance metabolic process;gene expression;tissue morphogenesis;protein N-linked glycosylation via asparagine;epithelium development;Golgi vesicle transport;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;regulation of hormone levels;single-organism developmental process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;vesicle localization;establishment of localization in cell;tube development;catabolic process;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;protein glycosylation;anatomical structure development;cellular metabolic process;single-organism organelle organization;single-organism intracellular transport;single-organism cellular localization;protein catabolic process; 3;5;6;6;5;4;4;4;4;5;2;4;3;3;7;4;3;5;4;4;4;7;5;5;6;4;3;4;5;4;6;6;3;6;5;4;5;7;4;5;3;5;2;3;4;5;4;4;5;6;4;2;4;3;4;5;5;3;5;4;1;5;3;8;4;4;4;4;5;3;2;5;5;6;4;5;2;2;4;5;5;7;2;5;6;4;6;5;5;5;4;4;4;4;6;4;4;4;5;6;4;5;5;5;5;5;5;2;3;5;4;6;5;6;5;5;5;6;4;3;4;5;3;5;4;4;3;2;3;3;4;3;4;4;3;3;4;5;4;5; GO:0005783;GO:0031974;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0097708;GO:0005794;GO:0005793;GO:0098588;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0005773;GO:0044444;GO:0000323;GO:0005788;GO:0005886;GO:0033116;GO:0005737;GO:0031090;GO:0031410;GO:0070062;GO:0044464;GO:0005623;GO:0071944;GO:0030133;GO:0030135;GO:0030134;GO:0005615;GO:0005576;GO:1903561;GO:0005575;GO:0070013;GO:0005764; endoplasmic reticulum;membrane-enclosed lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;intracellular vesicle;Golgi apparatus;endoplasmic reticulum-Golgi intermediate compartment;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;vacuole;cytoplasmic part;lytic vacuole;endoplasmic reticulum lumen;plasma membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;extracellular exosome;cell part;cell;cell periphery;transport vesicle;coated vesicle;ER to Golgi transport vesicle;extracellular space;extracellular region;extracellular vesicle;cellular_component;intracellular organelle lumen;lysosome; 4;2;4;5;2;5;4;4;5;4;3;4;3;3;2;2;3;3;3;2;4;4;3;5;3;5;4;6;5;3;5;4;3;5;4;2;2;3;4;6;5;3;2;3;1;4;7; GO:0003674;GO:0004197;GO:0016787;GO:0003824;GO:0004175;GO:0008233;GO:0008234;GO:0070011; molecular_function;cysteine-type endopeptidase activity;hydrolase activity;catalytic activity;endopeptidase activity;peptidase activity;cysteine-type peptidase activity;peptidase activity, acting on L-amino acid peptides; 1;7;3;2;6;4;6;5; K08568 map04142;map04210; Lysosome;Apoptosis; IPR033157;IPR000668;IPR025661;IPR013128; Cathepsin X;Peptidase C1A, papain C-terminal;Cysteine peptidase, asparagine active site;Peptidase C1A; extracellular Hs14786522 630.0 O [O] Posttranslational modification, protein turnover, chaperones; Q8NF91 Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4 - [SYNE1_HUMAN] 0.864 0.915 0.836 1.6 0.861 0.814 0.944262295 0.795220135 1.858304297 0.407888488 0.913661202 0.953811983 0.945412311 0.577256762 GO:0008104;GO:0051656;GO:0051651;GO:0071840;GO:0070727;GO:0048869;GO:0010256;GO:0033036;GO:0030154;GO:0045185;GO:0065008;GO:0042692;GO:0016043;GO:0065007;GO:0008150;GO:0051235;GO:0051234;GO:0090292;GO:0040023;GO:0061061;GO:0051457;GO:0044699;GO:0090286;GO:1902578;GO:0032502;GO:0032507;GO:0072595;GO:0009987;GO:0043578;GO:0007030;GO:0033365;GO:0034504;GO:0034613;GO:0044767;GO:0044763;GO:0051649;GO:0051647;GO:0051179;GO:0051640;GO:0051641;GO:0006996;GO:0006997;GO:0007010;GO:0048856;GO:1902589; protein localization;establishment of organelle localization;maintenance of location in cell;cellular component organization or biogenesis;cellular macromolecule localization;cellular developmental process;endomembrane system organization;macromolecule localization;cell differentiation;maintenance of protein location;regulation of biological quality;muscle cell differentiation;cellular component organization;biological regulation;biological_process;maintenance of location;establishment of localization;nuclear matrix anchoring at nuclear membrane;establishment of nucleus localization;muscle structure development;maintenance of protein location in nucleus;single-organism process;cytoskeletal anchoring at nuclear membrane;single-organism localization;developmental process;maintenance of protein location in cell;maintenance of protein localization in organelle;cellular process;nuclear matrix organization;Golgi organization;protein localization to organelle;protein localization to nucleus;cellular protein localization;single-organism developmental process;single-organism cellular process;establishment of localization in cell;nucleus localization;localization;organelle localization;cellular localization;organelle organization;nucleus organization;cytoskeleton organization;anatomical structure development;single-organism organelle organization; 4;4;4;2;4;4;4;3;5;4;3;5;3;2;1;3;3;5;5;4;7;2;5;3;2;5;6;2;6;5;6;7;5;3;3;4;5;2;4;3;4;5;5;3;4; GO:0031974;GO:0031975;GO:0097060;GO:0005654;GO:0031981;GO:0016021;GO:0016020;GO:0005794;GO:0098588;GO:0098589;GO:0031965;GO:0031967;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0034993;GO:0044449;GO:0005886;GO:0030016;GO:0030017;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0034992;GO:0044456;GO:0044459;GO:0042175;GO:0045211;GO:0032991;GO:0044464;GO:0019867;GO:0005623;GO:0005622;GO:0005640;GO:0031968;GO:0071944;GO:0045202;GO:0098805;GO:0005575;GO:0070013;GO:0098794;GO:0043292; membrane-enclosed lumen;envelope;synaptic membrane;nucleoplasm;nuclear lumen;integral component of membrane;membrane;Golgi apparatus;bounding membrane of organelle;membrane region;nuclear membrane;organelle envelope;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;membrane part;organelle part;plasma membrane region;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;LINC complex;contractile fiber part;plasma membrane;myofibril;sarcomere;cytoplasm;organelle membrane;nucleus;nuclear envelope;microtubule organizing center attachment site;synapse part;plasma membrane part;nuclear outer membrane-endoplasmic reticulum membrane network;postsynaptic membrane;macromolecular complex;cell part;outer membrane;cell;intracellular;nuclear outer membrane;organelle outer membrane;cell periphery;synapse;whole membrane;cellular_component;intracellular organelle lumen;postsynapse;contractile fiber; 2;3;3;5;5;4;2;4;4;3;4;4;3;4;4;3;4;3;2;2;4;3;3;3;2;5;3;3;3;4;4;3;3;6;4;4;3;5;4;5;2;3;3;4;2;2;3;2;3;3;4;3;2;3;1;4;3;5; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003779;GO:0005521;GO:0008092;GO:0097159;GO:0046983;GO:0032403;GO:0042802;GO:0042803;GO:0044822;GO:0051015;GO:0003723;GO:0005515;GO:0044877; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;actin binding;lamin binding;cytoskeletal protein binding;organic cyclic compound binding;protein dimerization activity;protein complex binding;identical protein binding;protein homodimerization activity;poly(A) RNA binding;actin filament binding;RNA binding;protein binding;macromolecular complex binding; 3;1;2;4;5;4;4;3;4;4;4;5;6;5;5;3;3; K19326 IPR002017;IPR012315;IPR018159;IPR001715;IPR001589;IPR030265; Spectrin repeat;KASH domain;Spectrin/alpha-actinin;Calponin homology domain;Actinin-type actin-binding domain, conserved site;Nesprin-1; nucleus Hs19526753 6745.0 Z [Z] Cytoskeleton; Q9UFH2 Dynein heavy chain 17, axonemal OS=Homo sapiens OX=9606 GN=DNAH17 PE=1 SV=3 - [DYH17_HUMAN] 1.68 1.05 0.657 1.223 0.724 0.72 1.6 nan 1.689226519 nan 0.625714286 nan 0.994475138 nan GO:0001539;GO:0006928;GO:0051179;GO:0044699;GO:0009987;GO:0008150;GO:0040011;GO:0007017;GO:0048870;GO:0007018;GO:0051674;GO:0044763; cilium or flagellum-dependent cell motility;movement of cell or subcellular component;localization;single-organism process;cellular process;biological_process;locomotion;microtubule-based process;cell motility;microtubule-based movement;localization of cell;single-organism cellular process; 4;4;2;2;2;1;2;4;3;5;3;3; GO:0099512;GO:0099513;GO:0044464;GO:0043229;GO:0043228;GO:0005929;GO:0030286;GO:0005874;GO:0043226;GO:0005737;GO:0044446;GO:0005858;GO:0005875;GO:0044430;GO:0005856;GO:0015630;GO:1902494;GO:0042995;GO:0005930;GO:0043234;GO:0032991;GO:0043232;GO:0044463;GO:0005623;GO:0005622;GO:0005575;GO:0044447;GO:0097014;GO:0044441;GO:0044424;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;cell part;intracellular organelle;non-membrane-bounded organelle;cilium;dynein complex;microtubule;organelle;cytoplasm;intracellular organelle part;axonemal dynein complex;microtubule associated complex;cytoskeletal part;cytoskeleton;microtubule cytoskeleton;catalytic complex;cell projection;axoneme;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cell projection part;cell;intracellular;cellular_component;axoneme part;ciliary plasm;ciliary part;intracellular part;organelle part; 2;3;2;3;3;3;5;4;2;4;3;5;4;4;5;6;4;3;4;3;2;4;3;2;3;1;4;4;3;3;2; GO:0032550;GO:0016787;GO:0035639;GO:1901363;GO:0032553;GO:0003674;GO:0005488;GO:0016887;GO:0043167;GO:0001882;GO:0016462;GO:0005524;GO:0032555;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0001883;GO:0000166;GO:0017111;GO:0036094;GO:0003824;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0032559;GO:0043168; purine ribonucleoside binding;hydrolase activity;purine ribonucleoside triphosphate binding;heterocyclic compound binding;ribonucleotide binding;molecular_function;binding;ATPase activity;ion binding;nucleoside binding;pyrophosphatase activity;ATP binding;purine ribonucleotide binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;purine nucleoside binding;nucleotide binding;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;adenyl ribonucleotide binding;anion binding; 6;3;5;3;4;1;2;8;3;4;6;6;5;4;5;5;8;9;5;4;7;3;2;5;6;3;3;4;6;4; K10408 map05016; Huntington's disease; IPR011704;IPR004273;IPR035699;IPR013594;IPR013602;IPR024743;IPR035706;IPR026983;IPR027417;IPR024317; ATPase, dynein-related, AAA domain;Dynein heavy chain domain;Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;Dynein heavy chain, domain-1;Dynein heavy chain, domain-2;Dynein heavy chain, coiled coil stalk;Dynein heavy chain, ATP-binding dynein motor region D5;Dynein heavy chain;P-loop containing nucleoside triphosphate hydrolase;Dynein heavy chain, AAA module D4; plasma membrane Hs13876382 5921.0 Z [Z] Cytoskeleton; P15104 Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4 - [GLNA_HUMAN] 0.763 0.902 1.291 1.018 1.024 1.529 0.845898004 nan 0.994140625 nan 1.431263858 nan 1.493164063 nan GO:0090087;GO:0032024;GO:0008104;GO:0051046;GO:0051047;GO:0051049;GO:0001504;GO:0044281;GO:0044282;GO:0043648;GO:0009267;GO:0044710;GO:0044711;GO:0006541;GO:0006542;GO:0046879;GO:0048518;GO:0033036;GO:0042127;GO:0043649;GO:0051050;GO:0045184;GO:0090276;GO:0090277;GO:0006836;GO:0043436;GO:0010033;GO:1901565;GO:0044700;GO:0031668;GO:0031669;GO:1901564;GO:1901566;GO:0034284;GO:0015833;GO:0098916;GO:0033554;GO:0001505;GO:0022607;GO:1903532;GO:0016053;GO:0009063;GO:0032940;GO:0006807;GO:0009065;GO:0009064;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0030073;GO:1901576;GO:0010646;GO:0050708;GO:0016043;GO:0065003;GO:0065007;GO:0071840;GO:0065008;GO:0070201;GO:0009306;GO:0006810;GO:0050796;GO:0050794;GO:0006950;GO:0051716;GO:0008150;GO:0008152;GO:0051234;GO:0008652;GO:0046903;GO:0050714;GO:0046394;GO:0050896;GO:0009058;GO:0016054;GO:0051966;GO:0044283;GO:0051968;GO:0099536;GO:0099537;GO:0035249;GO:0019676;GO:0070271;GO:0050806;GO:0050804;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:1903530;GO:0023051;GO:0010647;GO:1904951;GO:0044699;GO:0032880;GO:0042886;GO:0009056;GO:0050673;GO:1901605;GO:1901607;GO:1901606;GO:0008284;GO:1901700;GO:0071496;GO:0008283;GO:0009987;GO:0046883;GO:0044712;GO:0046887;GO:0032879;GO:0051259;GO:0042221;GO:0050678;GO:0050679;GO:0006082;GO:0006536;GO:0046395;GO:0009084;GO:0006538;GO:0009991;GO:0060341;GO:0043933;GO:0019752;GO:0042594;GO:0007270;GO:0009749;GO:0031667;GO:0071822;GO:0006520;GO:0051260;GO:0071705;GO:0071704;GO:0071702;GO:0009605;GO:0006461;GO:1901575;GO:0023061;GO:0010817;GO:0044765;GO:0044763;GO:0007268;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0009746;GO:0044238;GO:0009743;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:0009914;GO:0044085;GO:0044248;GO:0015031;GO:0098657;GO:0048522; regulation of peptide transport;positive regulation of insulin secretion;protein localization;regulation of secretion;positive regulation of secretion;regulation of transport;neurotransmitter uptake;small molecule metabolic process;small molecule catabolic process;dicarboxylic acid metabolic process;cellular response to starvation;single-organism metabolic process;single-organism biosynthetic process;glutamine metabolic process;glutamine biosynthetic process;hormone secretion;positive regulation of biological process;macromolecule localization;regulation of cell proliferation;dicarboxylic acid catabolic process;positive regulation of transport;establishment of protein localization;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;neurotransmitter transport;oxoacid metabolic process;response to organic substance;organonitrogen compound catabolic process;single organism signaling;cellular response to extracellular stimulus;cellular response to nutrient levels;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;response to monosaccharide;peptide transport;anterograde trans-synaptic signaling;cellular response to stress;regulation of neurotransmitter levels;cellular component assembly;positive regulation of secretion by cell;organic acid biosynthetic process;cellular amino acid catabolic process;secretion by cell;nitrogen compound metabolic process;glutamine family amino acid catabolic process;glutamine family amino acid metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;organic substance biosynthetic process;regulation of cell communication;regulation of protein secretion;cellular component organization;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;regulation of biological quality;regulation of establishment of protein localization;protein secretion;transport;regulation of insulin secretion;regulation of cellular process;response to stress;cellular response to stimulus;biological_process;metabolic process;establishment of localization;cellular amino acid biosynthetic process;secretion;positive regulation of protein secretion;carboxylic acid biosynthetic process;response to stimulus;biosynthetic process;organic acid catabolic process;regulation of synaptic transmission, glutamatergic;small molecule biosynthetic process;positive regulation of synaptic transmission, glutamatergic;synaptic signaling;trans-synaptic signaling;synaptic transmission, glutamatergic;ammonia assimilation cycle;protein complex biogenesis;positive regulation of synaptic transmission;modulation of synaptic transmission;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of secretion by cell;regulation of signaling;positive regulation of cell communication;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;amide transport;catabolic process;epithelial cell proliferation;alpha-amino acid metabolic process;alpha-amino acid biosynthetic process;alpha-amino acid catabolic process;positive regulation of cell proliferation;response to oxygen-containing compound;cellular response to external stimulus;cell proliferation;cellular process;regulation of hormone secretion;single-organism catabolic process;positive regulation of hormone secretion;regulation of localization;protein oligomerization;response to chemical;regulation of epithelial cell proliferation;positive regulation of epithelial cell proliferation;organic acid metabolic process;glutamate metabolic process;carboxylic acid catabolic process;glutamine family amino acid biosynthetic process;glutamate catabolic process;response to extracellular stimulus;regulation of cellular localization;macromolecular complex subunit organization;carboxylic acid metabolic process;response to starvation;neuron-neuron synaptic transmission;response to glucose;response to nutrient levels;protein complex subunit organization;cellular amino acid metabolic process;protein homooligomerization;nitrogen compound transport;organic substance metabolic process;organic substance transport;response to external stimulus;protein complex assembly;organic substance catabolic process;signal release;regulation of hormone levels;single-organism transport;single-organism cellular process;synaptic transmission;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;response to hexose;primary metabolic process;response to carbohydrate;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;hormone transport;cellular component biogenesis;cellular catabolic process;protein transport;import into cell;positive regulation of cellular process; 5;6;4;5;4;4;5;4;5;7;5;3;4;7;8;6;2;3;4;7;3;4;5;5;5;5;4;5;3;4;5;4;5;6;6;7;4;4;4;4;5;5;4;3;7;6;4;5;2;7;6;4;4;6;3;5;2;2;3;5;5;4;6;3;3;3;1;2;3;5;5;5;6;2;3;5;5;5;5;5;6;10;8;4;4;4;3;4;4;2;5;3;4;3;2;4;5;3;4;5;6;6;4;4;4;3;2;4;4;4;3;6;3;5;5;4;7;6;7;8;4;4;4;6;4;9;8;5;5;4;7;5;3;5;3;5;4;5;4;4;3;8;4;4;2;3;3;7;3;5;6;6;5;3;5;3;4;5;5;3; GO:0005783;GO:0030424;GO:0043204;GO:0097458;GO:0043209;GO:0005791;GO:0044297;GO:0036477;GO:0043230;GO:0042995;GO:0043234;GO:0043231;GO:0005829;GO:0044424;GO:0044421;GO:0043227;GO:0043679;GO:0043025;GO:0005737;GO:0012505;GO:0031982;GO:0044444;GO:0033267;GO:0097386;GO:0005634;GO:0005739;GO:0043005;GO:0044463;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0044306;GO:0070062;GO:0043226;GO:0005576;GO:1903561;GO:0032991;GO:0005575; endoplasmic reticulum;axon;perikaryon;neuron part;myelin sheath;rough endoplasmic reticulum;cell body;somatodendritic compartment;extracellular organelle;cell projection;protein complex;intracellular membrane-bounded organelle;cytosol;intracellular part;extracellular region part;membrane-bounded organelle;axon terminus;neuronal cell body;cytoplasm;endomembrane system;vesicle;cytoplasmic part;axon part;glial cell projection;nucleus;mitochondrion;neuron projection;cell projection part;cell part;intracellular organelle;cell;intracellular;neuron projection terminus;extracellular exosome;organelle;extracellular region;extracellular vesicle;macromolecular complex;cellular_component; 4;5;4;3;3;5;3;4;3;3;3;4;5;3;2;3;5;4;4;3;4;4;4;4;5;5;4;3;2;3;2;3;4;4;2;2;3;2;1; GO:0016211;GO:0016597;GO:1901363;GO:0016595;GO:0097367;GO:0004356;GO:0016880;GO:0003674;GO:0005488;GO:0030145;GO:0046914;GO:0032549;GO:0017076;GO:0005524;GO:0000166;GO:0003824;GO:0032555;GO:0097159;GO:0031406;GO:0032559;GO:0016829;GO:0035639;GO:0043168;GO:0043169;GO:0000287;GO:0043167;GO:0046872;GO:0030554;GO:0043177;GO:0032550;GO:0042802;GO:0005515;GO:0016830;GO:0016831;GO:0004351;GO:0001883;GO:1901265;GO:0001882;GO:0036094;GO:0016879;GO:0016874;GO:0032553; ammonia ligase activity;amino acid binding;heterocyclic compound binding;glutamate binding;carbohydrate derivative binding;glutamate-ammonia ligase activity;acid-ammonia (or amide) ligase activity;molecular_function;binding;manganese ion binding;transition metal ion binding;ribonucleoside binding;purine nucleotide binding;ATP binding;nucleotide binding;catalytic activity;purine ribonucleotide binding;organic cyclic compound binding;carboxylic acid binding;adenyl ribonucleotide binding;lyase activity;purine ribonucleoside triphosphate binding;anion binding;cation binding;magnesium ion binding;ion binding;metal ion binding;adenyl nucleotide binding;organic acid binding;purine ribonucleoside binding;identical protein binding;protein binding;carbon-carbon lyase activity;carboxy-lyase activity;glutamate decarboxylase activity;purine nucleoside binding;nucleoside phosphate binding;nucleoside binding;small molecule binding;ligase activity, forming carbon-nitrogen bonds;ligase activity;ribonucleotide binding; 6;6;3;7;3;7;5;1;2;7;6;5;5;6;4;2;5;3;5;6;3;5;4;4;6;3;5;6;4;6;4;3;4;5;6;5;4;4;3;4;3;4; K01915 map00220;map00250;map00630;map00910;map01100;map01120;map01230;map02020;map04724;map04727; Arginine biosynthesis;"Alanine, aspartate and glutamate metabolism";Glyoxylate and dicarboxylate metabolism;Nitrogen metabolism;Metabolic pathways;Microbial metabolism in diverse environments;Biosynthesis of amino acids;Two-component system;Glutamatergic synapse;GABAergic synapse; IPR008147;IPR008146;IPR014746;IPR027302;IPR027303; Glutamine synthetase, beta-Grasp domain;Glutamine synthetase, catalytic domain;Glutamine synthetase/guanido kinase, catalytic domain;Glutamine synthetase, N-terminal conserved site;Glutamine synthetase, glycine-rich site; cytosol Hs19923206 789.0 E [E] Amino acid transport and metabolism; Q5M8T2 Solute carrier family 35 member D3 OS=Homo sapiens OX=9606 GN=SLC35D3 PE=2 SV=1 - [S35D3_HUMAN] nan nan nan nan nan nan nan 0.03890626 nan 0.000201076 nan 0.000347741 nan 0.000362044 GO:0006810;GO:0008643;GO:0044765;GO:0008150;GO:0044699;GO:0071702;GO:1902578;GO:0051234;GO:0051179; transport;carbohydrate transport;single-organism transport;biological_process;single-organism process;organic substance transport;single-organism localization;establishment of localization;localization; 4;5;4;1;2;5;3;3;2; GO:0016021;GO:0016020;GO:0005575;GO:0044425;GO:0031224; integral component of membrane;membrane;cellular_component;membrane part;intrinsic component of membrane; 4;2;1;2;3; K15281 plasma membrane Hs17463142 840.0 GOU [G] Carbohydrate transport and metabolism;[O] Posttranslational modification, protein turnover, chaperones;[U] Intracellular trafficking, secretion, and vesicular transport; Q9GZU2 Paternally-expressed gene 3 protein OS=Homo sapiens OX=9606 GN=PEG3 PE=1 SV=1 - [PEG3_HUMAN] 0.614 0.88 0.741 0.716 0.65 6.64 0.697727273 nan 1.101538462 nan 0.842045455 nan 10.21538462 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0000122;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051253;GO:0051252;GO:0010629;GO:0043170;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0008219;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045934;GO:0019219;GO:0006915;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;programmed cell death;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell death;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 4;3;5;4;4;2;4;6;4;5;3;4;3;2;7;4;4;2;7;5;4;3;5;1;2;5;5;5;6;5;6;5;6;4;4;5;2;4;7;2;4;7;7;6;5;5;5;4;5;5;4;4;5;4;6;6;3;5;7;5;5;5;6;6;3;5;3;4;4;3;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;organelle;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;3;5;3;4;5;2;2;2;1;4; GO:0001071;GO:1901363;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:0000981;GO:0043169;GO:0097159;GO:0043167;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;metal ion binding;molecular_function;binding;nucleic acid binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;cation binding;organic cyclic compound binding;ion binding;transcription factor activity, sequence-specific DNA binding; 2;3;5;1;2;4;4;4;3;3;3; K09230 IPR013087;IPR008916;IPR003309;IPR027775;IPR013083; Zinc finger C2H2-type;Retrovirus capsid, C-terminal;SCAN domain;C2H2- zinc finger protein family subset;Zinc finger, RING/FYVE/PHD-type; nucleus Hs21361474 3306.0 R [R] General function prediction only; O60308 Centrosomal protein of 104 kDa OS=Homo sapiens OX=9606 GN=CEP104 PE=1 SV=1 - [CE104_HUMAN] 0.999 1.03 0.643 1.713 0.977 1.083 0.969902913 0.821726277 1.75332651 0.033906152 0.624271845 0.115536174 1.108495394 0.509687381 GO:0005856;GO:0005737;GO:0015630;GO:0005815;GO:0043232;GO:0005813;GO:0044446;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0043228;GO:0005814;GO:0044430;GO:0044424;GO:0042995;GO:0043226;GO:0044422;GO:0044450; cytoskeleton;cytoplasm;microtubule cytoskeleton;microtubule organizing center;intracellular non-membrane-bounded organelle;centrosome;intracellular organelle part;cell part;intracellular organelle;cell;intracellular;cellular_component;cytoplasmic part;non-membrane-bounded organelle;centriole;cytoskeletal part;intracellular part;cell projection;organelle;organelle part;microtubule organizing center part; 5;4;6;5;4;5;3;2;3;2;3;1;4;3;5;4;3;3;2;2;5; K16458 IPR034085;IPR016024;IPR011989;IPR008979; TOG domain;Armadillo-type fold;Armadillo-like helical;Galactose-binding domain-like; nucleus Hs7662180 1916.0 T [T] Signal transduction mechanisms; Q96NE9 FERM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=FRMD6 PE=1 SV=1 - [FRMD6_HUMAN] 1.216 0.547 0.984 1.833 0.793 0.817 2.223034735 nan 2.31147541 nan 1.798903108 nan 1.030264817 nan GO:0008104;GO:0060429;GO:0030154;GO:0048468;GO:0006928;GO:0003382;GO:0003383;GO:0009653;GO:0050789;GO:0044699;GO:0000904;GO:0000902;GO:0070727;GO:0048869;GO:0016043;GO:0065007;GO:0071840;GO:0030855;GO:0033036;GO:0034613;GO:0032502;GO:0032970;GO:0030029;GO:0009987;GO:0009888;GO:0050794;GO:0044767;GO:0030048;GO:0044763;GO:0051179;GO:0051641;GO:0048856;GO:0032989;GO:0008150;GO:0070252;GO:0002064; protein localization;epithelium development;cell differentiation;cell development;movement of cell or subcellular component;epithelial cell morphogenesis;apical constriction;anatomical structure morphogenesis;regulation of biological process;single-organism process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule localization;cellular developmental process;cellular component organization;biological regulation;cellular component organization or biogenesis;epithelial cell differentiation;macromolecule localization;cellular protein localization;developmental process;regulation of actin filament-based process;actin filament-based process;cellular process;tissue development;regulation of cellular process;single-organism developmental process;actin filament-based movement;single-organism cellular process;localization;cellular localization;anatomical structure development;cellular component morphogenesis;biological_process;actin-mediated cell contraction;epithelial cell development; 4;5;5;4;4;6;7;3;2;2;5;5;4;4;3;2;2;6;3;5;2;4;4;2;4;3;3;5;3;2;3;3;4;1;6;5; GO:0043229;GO:0043228;GO:0005737;GO:0016020;GO:0043226;GO:0005856;GO:0005911;GO:0005886;GO:0043232;GO:0030054;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0071944;GO:0044424;GO:0043296; intracellular organelle;non-membrane-bounded organelle;cytoplasm;membrane;organelle;cytoskeleton;cell-cell junction;plasma membrane;intracellular non-membrane-bounded organelle;cell junction;cell part;cell;intracellular;cellular_component;cell periphery;intracellular part;apical junction complex; 3;3;4;2;2;5;3;3;4;2;2;2;3;1;3;3;4; K16822 map04390; Hippo signaling pathway; IPR019749;IPR019748;IPR029071;IPR014352;IPR018979;IPR011993;IPR018980;IPR000299; Band 4.1 domain;FERM central domain;Ubiquitin-related domain;FERM/acyl-CoA-binding protein, 3-helical bundle;FERM, N-terminal;PH domain-like;FERM, C-terminal PH-like domain;FERM domain; nucleus Hs20543262 1298.0 T [T] Signal transduction mechanisms; Q14644 Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3 - [RASA3_HUMAN] 1.637 0.715 1.017 1.106 0.769 0.667 2.28951049 nan 1.438231469 nan 1.422377622 nan 0.867360208 nan GO:0048010;GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0032147;GO:0032845;GO:0032844;GO:0007165;GO:0007166;GO:0007167;GO:0030182;GO:0007169;GO:0043434;GO:0023014;GO:0010648;GO:0051716;GO:0010604;GO:0042330;GO:0009966;GO:0009967;GO:0071840;GO:0000165;GO:0070848;GO:0051208;GO:0051209;GO:0044093;GO:0048518;GO:0048519;GO:0051345;GO:0019725;GO:0038179;GO:0006935;GO:0060255;GO:0048468;GO:0045859;GO:0006952;GO:0051283;GO:0042221;GO:0051282;GO:0007173;GO:1902656;GO:0070838;GO:0097485;GO:0010033;GO:0042325;GO:0044700;GO:0042327;GO:0009605;GO:0044707;GO:0019538;GO:0010243;GO:0070588;GO:0007204;GO:0060402;GO:0002376;GO:0070509;GO:0048878;GO:0055074;GO:0009893;GO:0033674;GO:0006928;GO:0098771;GO:0031175;GO:0035556;GO:0071900;GO:0006955;GO:0050789;GO:0044267;GO:0009653;GO:0051347;GO:0000902;GO:0044260;GO:0043087;GO:0043549;GO:0044344;GO:0016043;GO:0098662;GO:0065007;GO:0044699;GO:0098660;GO:0065009;GO:0065008;GO:0097553;GO:0006810;GO:0061564;GO:0006812;GO:0006811;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:1901700;GO:0008152;GO:0051238;GO:1902532;GO:1902533;GO:0051235;GO:1902531;GO:0071375;GO:0044767;GO:0009968;GO:0046907;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0002764;GO:0048812;GO:0050776;GO:0048869;GO:0071774;GO:0002768;GO:0016310;GO:0050801;GO:0030154;GO:0046578;GO:0023056;GO:0023057;GO:0043405;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0007411;GO:0010647;GO:0010646;GO:0008543;GO:0007265;GO:0043085;GO:0043408;GO:0009719;GO:0072507;GO:0072503;GO:0051649;GO:0010562;GO:1901701;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0051641;GO:0048011;GO:0032502;GO:0051336;GO:0008286;GO:0032501;GO:0006875;GO:0009987;GO:0006873;GO:0032870;GO:0038095;GO:0030001;GO:0007409;GO:0055080;GO:0055082;GO:0032879;GO:0055085;GO:0048858;GO:0032268;GO:0071363;GO:0009725;GO:0043170;GO:0006816;GO:0048731;GO:0045860;GO:1901698;GO:0030003;GO:0000186;GO:1901699;GO:0051056;GO:0030030;GO:0072511;GO:0031325;GO:0031323;GO:0042592;GO:0032868;GO:0032869;GO:0051234;GO:0051058;GO:0007275;GO:0002682;GO:0038093;GO:0071417;GO:0032989;GO:0071704;GO:0071310;GO:0006874;GO:0048666;GO:0048667;GO:0006468;GO:0060401;GO:0045937;GO:0045087;GO:0006464;GO:0051174;GO:0034220;GO:0044765;GO:0000904;GO:0044763;GO:0046580;GO:0055065;GO:0007154;GO:0022008;GO:0007264;GO:0051179;GO:1902578;GO:0043547;GO:0040011;GO:0044238;GO:0048699;GO:0098655;GO:0032990;GO:0007399;GO:0051480;GO:0048856;GO:0044237;GO:0071495;GO:0006796;GO:2000021;GO:1901652;GO:1901653;GO:0006793;GO:1902582;GO:0001932;GO:0001934;GO:0048523;GO:0048522; vascular endothelial growth factor receptor signaling pathway;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;negative regulation of homeostatic process;regulation of homeostatic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;neuron differentiation;transmembrane receptor protein tyrosine kinase signaling pathway;response to peptide hormone;signal transduction by protein phosphorylation;negative regulation of cell communication;cellular response to stimulus;positive regulation of macromolecule metabolic process;taxis;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;response to growth factor;sequestering of calcium ion;release of sequestered calcium ion into cytosol;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;positive regulation of hydrolase activity;cellular homeostasis;neurotrophin signaling pathway;chemotaxis;regulation of macromolecule metabolic process;cell development;regulation of protein kinase activity;defense response;negative regulation of sequestering of calcium ion;response to chemical;regulation of sequestering of calcium ion;epidermal growth factor receptor signaling pathway;calcium ion import into cytosol;divalent metal ion transport;neuron projection guidance;response to organic substance;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;response to external stimulus;single-multicellular organism process;protein metabolic process;response to organonitrogen compound;calcium ion transmembrane transport;positive regulation of cytosolic calcium ion concentration;calcium ion transport into cytosol;immune system process;calcium ion import;chemical homeostasis;calcium ion homeostasis;positive regulation of metabolic process;positive regulation of kinase activity;movement of cell or subcellular component;inorganic ion homeostasis;neuron projection development;intracellular signal transduction;regulation of protein serine/threonine kinase activity;immune response;regulation of biological process;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cell morphogenesis;cellular macromolecule metabolic process;regulation of GTPase activity;regulation of kinase activity;cellular response to fibroblast growth factor stimulus;cellular component organization;inorganic cation transmembrane transport;biological regulation;single-organism process;inorganic ion transmembrane transport;regulation of molecular function;regulation of biological quality;calcium ion transmembrane import into cytosol;transport;axon development;cation transport;ion transport;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;response to oxygen-containing compound;metabolic process;sequestering of metal ion;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;maintenance of location;regulation of intracellular signal transduction;cellular response to peptide hormone stimulus;single-organism developmental process;negative regulation of signal transduction;intracellular transport;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;immune response-regulating signaling pathway;neuron projection morphogenesis;regulation of immune response;cellular developmental process;response to fibroblast growth factor;immune response-regulating cell surface receptor signaling pathway;phosphorylation;ion homeostasis;cell differentiation;regulation of Ras protein signal transduction;positive regulation of signaling;negative regulation of signaling;regulation of MAP kinase activity;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;axon guidance;positive regulation of cell communication;regulation of cell communication;fibroblast growth factor receptor signaling pathway;Ras protein signal transduction;positive regulation of catalytic activity;regulation of MAPK cascade;response to endogenous stimulus;divalent inorganic cation homeostasis;cellular divalent inorganic cation homeostasis;establishment of localization in cell;positive regulation of phosphorus metabolic process;cellular response to oxygen-containing compound;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;cellular localization;neurotrophin TRK receptor signaling pathway;developmental process;regulation of hydrolase activity;insulin receptor signaling pathway;multicellular organismal process;cellular metal ion homeostasis;cellular process;cellular ion homeostasis;cellular response to hormone stimulus;Fc-epsilon receptor signaling pathway;metal ion transport;axonogenesis;cation homeostasis;cellular chemical homeostasis;regulation of localization;transmembrane transport;cell projection morphogenesis;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;response to hormone;macromolecule metabolic process;calcium ion transport;system development;positive regulation of protein kinase activity;response to nitrogen compound;cellular cation homeostasis;activation of MAPKK activity;cellular response to nitrogen compound;regulation of small GTPase mediated signal transduction;cell projection organization;divalent inorganic cation transport;positive regulation of cellular metabolic process;regulation of cellular metabolic process;homeostatic process;response to insulin;cellular response to insulin stimulus;establishment of localization;negative regulation of small GTPase mediated signal transduction;multicellular organism development;regulation of immune system process;Fc receptor signaling pathway;cellular response to organonitrogen compound;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;cellular calcium ion homeostasis;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;cytosolic calcium ion transport;positive regulation of phosphate metabolic process;innate immune response;cellular protein modification process;regulation of phosphorus metabolic process;ion transmembrane transport;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;negative regulation of Ras protein signal transduction;metal ion homeostasis;cell communication;neurogenesis;small GTPase mediated signal transduction;localization;single-organism localization;positive regulation of GTPase activity;locomotion;primary metabolic process;generation of neurons;cation transmembrane transport;cell part morphogenesis;nervous system development;regulation of cytosolic calcium ion concentration;anatomical structure development;cellular metabolic process;cellular response to endogenous stimulus;phosphate-containing compound metabolic process;regulation of ion homeostasis;response to peptide;cellular response to peptide;phosphorus metabolic process;single-organism intracellular transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 8;6;4;3;3;3;3;9;3;3;4;5;6;6;7;5;4;4;3;4;3;4;4;2;5;5;5;5;4;2;2;6;4;6;4;4;4;7;4;4;3;4;9;7;8;5;4;7;3;7;3;3;4;4;8;11;6;2;10;5;9;3;7;4;7;5;5;8;3;2;5;3;6;5;4;6;6;5;3;7;2;2;6;3;3;8;4;6;6;5;4;3;3;6;5;5;1;4;2;4;5;5;3;5;6;3;4;5;2;6;3;5;5;6;4;4;4;6;6;6;5;7;3;3;7;2;8;4;3;6;4;4;6;7;5;6;3;8;8;4;5;5;5;5;5;6;3;7;2;5;8;2;8;2;6;5;8;7;7;7;5;3;4;5;5;6;4;4;9;4;8;4;7;7;5;6;4;7;4;4;4;6;7;3;6;4;3;7;5;4;3;5;9;5;6;7;10;6;4;6;5;5;4;5;3;7;8;4;6;6;2;3;7;2;3;7;6;5;5;10;3;3;4;5;4;5;6;4;5;7;7;3;3; GO:0031224;GO:0016020;GO:0044459;GO:0044424;GO:0044425;GO:0005829;GO:0009898;GO:0005886;GO:0005737;GO:0044444;GO:0031235;GO:0044464;GO:0005623;GO:0098552;GO:0098562;GO:0071944;GO:0005575;GO:0005622;GO:0031226; intrinsic component of membrane;membrane;plasma membrane part;intracellular part;membrane part;cytosol;cytoplasmic side of plasma membrane;plasma membrane;cytoplasm;cytoplasmic part;intrinsic component of the cytoplasmic side of the plasma membrane;cell part;cell;side of membrane;cytoplasmic side of membrane;cell periphery;cellular_component;intracellular;intrinsic component of plasma membrane; 3;2;3;3;2;5;4;3;4;4;5;2;2;3;4;3;1;3;4; GO:0005262;GO:0060089;GO:0022838;GO:0015085;GO:0046873;GO:0046872;GO:0005261;GO:0030695;GO:0008324;GO:0099604;GO:0099600;GO:0003674;GO:0005488;GO:0098772;GO:0022803;GO:0030234;GO:0043169;GO:0022891;GO:0022892;GO:0015075;GO:0015276;GO:0015278;GO:0072509;GO:0008047;GO:0022890;GO:0005215;GO:0005216;GO:0060589;GO:0022836;GO:0022834;GO:0038023;GO:0004888;GO:0004872;GO:0004871;GO:0005057;GO:0022857;GO:0015267;GO:0005096;GO:0043167;GO:0005217; calcium channel activity;molecular transducer activity;substrate-specific channel activity;calcium ion transmembrane transporter activity;metal ion transmembrane transporter activity;metal ion binding;cation channel activity;GTPase regulator activity;cation transmembrane transporter activity;ligand-gated calcium channel activity;transmembrane receptor activity;molecular_function;binding;molecular function regulator;passive transmembrane transporter activity;enzyme regulator activity;cation binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;ligand-gated ion channel activity;calcium-release channel activity;divalent inorganic cation transmembrane transporter activity;enzyme activator activity;inorganic cation transmembrane transporter activity;transporter activity;ion channel activity;nucleoside-triphosphatase regulator activity;gated channel activity;ligand-gated channel activity;signaling receptor activity;transmembrane signaling receptor activity;receptor activity;signal transducer activity;receptor signaling protein activity;transmembrane transporter activity;channel activity;GTPase activator activity;ion binding;intracellular ligand-gated ion channel activity; 8;2;5;9;8;5;7;5;6;5;4;1;2;2;4;3;4;4;3;5;6;4;8;4;7;2;6;4;6;5;3;4;3;2;3;3;5;5;3;7; K12380 map04013;map04014; MAPK signaling pathway - fly;Ras signaling pathway; IPR008936;IPR001936;IPR001562;IPR023152;IPR001849;IPR011993;IPR000008; Rho GTPase activation protein;Ras GTPase-activating protein;Zinc finger, Btk motif;Ras GTPase-activating protein, conserved site;Pleckstrin homology domain;PH domain-like;C2 domain; nucleus Hs12545410 1735.0 T [T] Signal transduction mechanisms; Q6P4A8 Phospholipase B-like 1 OS=Homo sapiens OX=9606 GN=PLBD1 PE=1 SV=2 - [PLBL1_HUMAN] 0.426 0.535 2.676 0.711 0.51 0.855 0.796261682 nan 1.394117647 nan 5.001869159 nan 1.676470588 nan GO:0006650;GO:0046474;GO:0044249;GO:0034641;GO:0006807;GO:0044281;GO:0036149;GO:0046486;GO:0044699;GO:0044710;GO:0044711;GO:0090407;GO:0097164;GO:0016042;GO:0071704;GO:0045017;GO:0006644;GO:0006629;GO:0009308;GO:1901576;GO:0009987;GO:1901575;GO:0009058;GO:0044763;GO:0008152;GO:0044712;GO:1901564;GO:0044255;GO:0009056;GO:0036151;GO:0008610;GO:0046488;GO:0044238;GO:0008654;GO:0042439;GO:0006576;GO:0044106;GO:0036152;GO:0044237;GO:0006066;GO:0006796;GO:0006793;GO:0019637;GO:0008150;GO:0046470;GO:1901615; glycerophospholipid metabolic process;glycerophospholipid biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;small molecule metabolic process;phosphatidylinositol acyl-chain remodeling;glycerolipid metabolic process;single-organism process;single-organism metabolic process;single-organism biosynthetic process;organophosphate biosynthetic process;ammonium ion metabolic process;lipid catabolic process;organic substance metabolic process;glycerolipid biosynthetic process;phospholipid metabolic process;lipid metabolic process;amine metabolic process;organic substance biosynthetic process;cellular process;organic substance catabolic process;biosynthetic process;single-organism cellular process;metabolic process;single-organism catabolic process;organonitrogen compound metabolic process;cellular lipid metabolic process;catabolic process;phosphatidylcholine acyl-chain remodeling;lipid biosynthetic process;phosphatidylinositol metabolic process;primary metabolic process;phospholipid biosynthetic process;ethanolamine-containing compound metabolic process;cellular biogenic amine metabolic process;cellular amine metabolic process;phosphatidylethanolamine acyl-chain remodeling;cellular metabolic process;alcohol metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;organophosphate metabolic process;biological_process;phosphatidylcholine metabolic process;organic hydroxy compound metabolic process; 6;6;4;4;3;4;8;5;2;3;4;5;4;5;3;5;5;4;5;4;2;4;3;3;2;4;4;4;3;6;5;7;3;5;4;6;5;6;3;5;5;4;4;1;5;4; GO:0000323;GO:0043226;GO:0044424;GO:0005622;GO:0043227;GO:0005737;GO:0005575;GO:0005615;GO:0005773;GO:0044444;GO:0005623;GO:0043231;GO:0005829;GO:0044464;GO:0043229;GO:0044421;GO:0005576;GO:0005764; lytic vacuole;organelle;intracellular part;intracellular;membrane-bounded organelle;cytoplasm;cellular_component;extracellular space;vacuole;cytoplasmic part;cell;intracellular membrane-bounded organelle;cytosol;cell part;intracellular organelle;extracellular region part;extracellular region;lysosome; 6;2;3;3;3;4;1;3;5;4;2;4;5;2;3;2;2;7; GO:0003674;GO:0016787;GO:0003824; molecular_function;hydrolase activity;catalytic activity; 1;3;2; IPR007000; Phospholipase B-like; extracellular Hs13376232 1050.0 T [T] Signal transduction mechanisms; Q9P2D0 Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3 - [IBTK_HUMAN] 0.823 0.832 1.602 0.879 1.04 0.563 0.989182692 nan 0.845192308 nan 1.925480769 nan 0.541346154 nan GO:0051348;GO:0019220;GO:0080090;GO:0019222;GO:0051282;GO:0051283;GO:0032844;GO:0055074;GO:0098771;GO:0010605;GO:0018212;GO:0051208;GO:0051209;GO:0044092;GO:0048519;GO:0019725;GO:0060255;GO:0032845;GO:0061097;GO:1902656;GO:0070838;GO:0042325;GO:0042326;GO:0019538;GO:0050730;GO:0050732;GO:0070588;GO:0007204;GO:0048878;GO:0070509;GO:0033673;GO:0009892;GO:0043170;GO:0050789;GO:0044267;GO:0044260;GO:0043549;GO:0065007;GO:0098662;GO:0098660;GO:0061099;GO:0065009;GO:0065008;GO:0097553;GO:0050790;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051238;GO:0051235;GO:0051234;GO:0045859;GO:0046907;GO:0031400;GO:0051338;GO:0016310;GO:0050801;GO:0055065;GO:0018193;GO:0043086;GO:0044699;GO:0072507;GO:0051248;GO:0072503;GO:0010563;GO:0051246;GO:0031399;GO:0006875;GO:0006874;GO:0009987;GO:0006873;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0032879;GO:0055085;GO:0032269;GO:0032268;GO:0072511;GO:0031324;GO:0031323;GO:0018108;GO:0042592;GO:0071704;GO:0006468;GO:0006469;GO:0060401;GO:0060402;GO:0045936;GO:0006464;GO:0051174;GO:0034220;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0001932;GO:0051480;GO:0044237;GO:0006796;GO:2000021;GO:0006793;GO:1902582;GO:0001933;GO:0098655;GO:0048523; negative regulation of transferase activity;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of sequestering of calcium ion;negative regulation of sequestering of calcium ion;regulation of homeostatic process;calcium ion homeostasis;inorganic ion homeostasis;negative regulation of macromolecule metabolic process;peptidyl-tyrosine modification;sequestering of calcium ion;release of sequestered calcium ion into cytosol;negative regulation of molecular function;negative regulation of biological process;cellular homeostasis;regulation of macromolecule metabolic process;negative regulation of homeostatic process;regulation of protein tyrosine kinase activity;calcium ion import into cytosol;divalent metal ion transport;regulation of phosphorylation;negative regulation of phosphorylation;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;negative regulation of peptidyl-tyrosine phosphorylation;calcium ion transmembrane transport;positive regulation of cytosolic calcium ion concentration;chemical homeostasis;calcium ion import;negative regulation of kinase activity;negative regulation of metabolic process;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;biological regulation;inorganic cation transmembrane transport;inorganic ion transmembrane transport;negative regulation of protein tyrosine kinase activity;regulation of molecular function;regulation of biological quality;calcium ion transmembrane import into cytosol;regulation of catalytic activity;cation transport;ion transport;transport;calcium ion transport;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;sequestering of metal ion;maintenance of location;establishment of localization;regulation of protein kinase activity;intracellular transport;negative regulation of protein modification process;regulation of transferase activity;phosphorylation;ion homeostasis;metal ion homeostasis;peptidyl-amino acid modification;negative regulation of catalytic activity;single-organism process;divalent inorganic cation homeostasis;negative regulation of protein metabolic process;cellular divalent inorganic cation homeostasis;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;regulation of protein modification process;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular process;cellular ion homeostasis;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of localization;transmembrane transport;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;divalent inorganic cation transport;negative regulation of cellular metabolic process;regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;homeostatic process;organic substance metabolic process;protein phosphorylation;negative regulation of protein kinase activity;cytosolic calcium ion transport;calcium ion transport into cytosol;negative regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;ion transmembrane transport;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;primary metabolic process;regulation of protein phosphorylation;regulation of cytosolic calcium ion concentration;cellular metabolic process;phosphate-containing compound metabolic process;regulation of ion homeostasis;phosphorus metabolic process;single-organism intracellular transport;negative regulation of protein phosphorylation;cation transmembrane transport;negative regulation of cellular process; 6;6;4;3;4;4;3;9;7;4;8;5;5;4;2;4;4;3;8;7;8;7;7;4;8;8;8;11;5;10;7;3;4;2;5;4;6;2;7;6;9;3;3;8;4;6;5;4;9;3;5;5;1;2;4;3;3;7;5;6;5;6;6;8;7;5;2;8;5;8;5;5;6;8;9;2;6;7;7;7;5;3;4;5;5;7;4;4;8;4;3;7;8;10;6;6;6;5;5;4;3;4;2;3;3;3;7;10;3;5;4;4;5;7;6;3; GO:0031974;GO:0031981;GO:0016020;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 2;5;2;4;3;4;3;2;3;3;5;3;4;5;2;2;3;2;1;4; GO:0098772;GO:0019901;GO:0019900;GO:0030292;GO:0003674;GO:0005488;GO:0019887;GO:0019899;GO:0004857;GO:0004860;GO:0005515;GO:0019207;GO:0019210;GO:0030234; molecular function regulator;protein kinase binding;kinase binding;protein tyrosine kinase inhibitor activity;molecular_function;binding;protein kinase regulator activity;enzyme binding;enzyme inhibitor activity;protein kinase inhibitor activity;protein binding;kinase regulator activity;kinase inhibitor activity;enzyme regulator activity; 2;6;5;7;1;2;5;4;4;6;3;4;5;3; IPR011333;IPR002110;IPR009091;IPR020683;IPR000210;IPR000408; SKP1/BTB/POZ domain;Ankyrin repeat;Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II;Ankyrin repeat-containing domain;BTB/POZ domain;Regulator of chromosome condensation, RCC1; nucleus Hs20547756 2814.0 S [S] Function unknown; Q9H223 EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1 - [EHD4_HUMAN] 1.028 0.963 1.198 0.795 1.029 1.332 1.067497404 nan 0.772594752 nan 1.244029076 nan 1.294460641 nan GO:0019220;GO:0019222;GO:0051049;GO:0006907;GO:0071840;GO:0080090;GO:0051716;GO:0010604;GO:0018212;GO:0070848;GO:0018193;GO:0048518;GO:0042325;GO:0060255;GO:0010033;GO:0016197;GO:0042327;GO:0016192;GO:0050731;GO:0050730;GO:0019538;GO:0022607;GO:0009893;GO:0050789;GO:0044267;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:0006810;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0006897;GO:0046907;GO:0050896;GO:0031401;GO:0070271;GO:0016310;GO:0051128;GO:0070887;GO:0044699;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0009987;GO:0060627;GO:0032879;GO:0051259;GO:0032268;GO:0071363;GO:0007034;GO:0043170;GO:0043933;GO:0031325;GO:0031323;GO:0018108;GO:0071822;GO:0051260;GO:0071704;GO:0071310;GO:0006468;GO:0045937;GO:0006461;GO:0006464;GO:0051174;GO:0044765;GO:0051649;GO:0042221;GO:0030100;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0044237;GO:0006796;GO:0044085;GO:0032456;GO:0006793;GO:1902582;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of metabolic process;regulation of transport;pinocytosis;cellular component organization or biogenesis;regulation of primary metabolic process;cellular response to stimulus;positive regulation of macromolecule metabolic process;peptidyl-tyrosine modification;response to growth factor;peptidyl-amino acid modification;positive regulation of biological process;regulation of phosphorylation;regulation of macromolecule metabolic process;response to organic substance;endosomal transport;positive regulation of phosphorylation;vesicle-mediated transport;positive regulation of peptidyl-tyrosine phosphorylation;regulation of peptidyl-tyrosine phosphorylation;protein metabolic process;cellular component assembly;positive regulation of metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;transport;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;endocytosis;intracellular transport;response to stimulus;positive regulation of protein modification process;protein complex biogenesis;phosphorylation;regulation of cellular component organization;cellular response to chemical stimulus;single-organism process;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;cellular process;regulation of vesicle-mediated transport;regulation of localization;protein oligomerization;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;vacuolar transport;macromolecule metabolic process;macromolecular complex subunit organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;protein complex subunit organization;protein homooligomerization;organic substance metabolic process;cellular response to organic substance;protein phosphorylation;positive regulation of phosphate metabolic process;protein complex assembly;cellular protein modification process;regulation of phosphorus metabolic process;single-organism transport;establishment of localization in cell;response to chemical;regulation of endocytosis;localization;single-organism localization;cellular localization;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;endocytic recycling;phosphorus metabolic process;single-organism intracellular transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;3;4;7;2;4;3;4;8;5;7;2;7;4;4;7;7;5;8;8;4;4;3;2;5;4;3;5;2;4;3;5;5;1;2;3;6;5;2;6;4;6;4;4;2;5;5;5;5;6;2;4;3;6;5;6;6;4;4;4;4;8;5;7;3;5;7;6;5;6;5;4;4;3;5;2;3;3;3;3;5;3;6;4;5;7;7;3; GO:0005783;GO:0005773;GO:0016020;GO:0005774;GO:0044437;GO:0031901;GO:0098588;GO:0043231;GO:0043230;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0048471;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0044440;GO:0005634;GO:0055038;GO:0055037;GO:0005886;GO:0010008;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005769;GO:0071944;GO:0070062;GO:0098805;GO:0043226;GO:0005576;GO:1903561;GO:0005575;GO:0005768; endoplasmic reticulum;vacuole;membrane;vacuolar membrane;vacuolar part;early endosome membrane;bounding membrane of organelle;intracellular membrane-bounded organelle;extracellular organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;perinuclear region of cytoplasm;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;endosomal part;nucleus;recycling endosome membrane;recycling endosome;plasma membrane;endosome membrane;cytoplasm;organelle membrane;cell part;cell;early endosome;cell periphery;extracellular exosome;whole membrane;organelle;extracellular region;extracellular vesicle;cellular_component;endosome; 4;5;2;4;4;6;4;4;3;3;2;2;3;3;3;5;3;4;3;4;5;5;6;5;3;5;4;3;2;2;5;3;4;3;2;2;3;1;4; GO:1901363;GO:0097367;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0005525;GO:0043168;GO:0036094;GO:0097159;GO:0019001;GO:0032559;GO:0032555;GO:0032553;GO:0035639;GO:0000166;GO:0043169;GO:0043167;GO:0032561;GO:0005509;GO:0030554;GO:0001883;GO:0001882;GO:0032550; heterocyclic compound binding;carbohydrate derivative binding;metal ion binding;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;GTP binding;anion binding;small molecule binding;organic cyclic compound binding;guanyl nucleotide binding;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;cation binding;ion binding;guanyl ribonucleotide binding;calcium ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;purine ribonucleoside binding; 3;3;5;1;2;4;4;5;5;6;6;4;3;3;6;6;5;4;5;4;4;3;6;6;6;5;4;6; K12477 map04144; Endocytosis; IPR031692;IPR018247;IPR029952;IPR000261;IPR030381;IPR022812;IPR011992;IPR002048;IPR027417; EH domain-containing protein, N-terminal;EF-Hand 1, calcium-binding site;EH domain-containing protein 4;EH domain;Dynamin-type guanine nucleotide-binding (G) domain;Dynamin superfamily;EF-hand domain pair;EF-hand domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs21264315 1118.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q8IV38 Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1 - [ANKY2_HUMAN] 0.993 0.92 1.231 0.92 1.034 1.103 1.079347826 nan 0.889748549 nan 1.338043478 nan 1.066731141 nan GO:0042995;GO:0044464;GO:0005623;GO:0005575;GO:0005929;GO:0043226; cell projection;cell part;cell;cellular_component;cilium;organelle; 3;2;2;1;3;2; GO:0043169;GO:0043167;GO:0003674;GO:0005488;GO:0046872; cation binding;ion binding;molecular_function;binding;metal ion binding; 4;3;1;2;5; IPR002110;IPR002893;IPR020683; Ankyrin repeat;Zinc finger, MYND-type;Ankyrin repeat-containing domain; cytosol Hs20539426 917.0 R [R] General function prediction only; Q6NUI1 Putative coiled-coil domain-containing protein 144 N-terminal-like OS=Homo sapiens OX=9606 GN=CCDC144NL PE=5 SV=1 - [C144L_HUMAN] 0.985 1.065 1.167 0.945 1.071 0.713 0.924882629 nan 0.882352941 nan 1.095774648 nan 0.66573296 nan cytosol, nucleus Q9Y6Q9 Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1 - [NCOA3_HUMAN] 1.391 1.053 0.819 0.982 0.972 0.93 1.320987654 nan 1.010288066 nan 0.777777778 nan 0.956790123 nan GO:0080090;GO:0019222;GO:0006473;GO:2001141;GO:0007165;GO:1901576;GO:1901362;GO:0071840;GO:0032774;GO:0009755;GO:0051716;GO:0010604;GO:0009966;GO:0048869;GO:0071391;GO:0018193;GO:0048513;GO:0044093;GO:0030855;GO:0048518;GO:0030858;GO:0016570;GO:0016573;GO:0030216;GO:0060255;GO:0006475;GO:0006366;GO:0034645;GO:0030518;GO:0010033;GO:0046483;GO:0044700;GO:0044707;GO:0019538;GO:0051171;GO:0018205;GO:0071407;GO:0019438;GO:0016569;GO:2000273;GO:0009893;GO:0009891;GO:0023051;GO:0010628;GO:0043170;GO:0050789;GO:0097659;GO:0044267;GO:0010646;GO:0016043;GO:0065007;GO:0014070;GO:0045944;GO:0065009;GO:0018130;GO:0018393;GO:0035624;GO:0018394;GO:0050793;GO:0009889;GO:0044710;GO:0071310;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0050794;GO:0045616;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0043401;GO:0010556;GO:0016568;GO:0097305;GO:0051240;GO:0097306;GO:0051239;GO:0030154;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0008544;GO:0044699;GO:0009719;GO:0006139;GO:0030856;GO:0031325;GO:0071495;GO:1901700;GO:0032501;GO:1901701;GO:0071392;GO:0009987;GO:0071396;GO:0048583;GO:0045597;GO:0032870;GO:0045893;GO:0051276;GO:0051094;GO:0009725;GO:0051252;GO:0051254;GO:1902680;GO:0045618;GO:0048731;GO:0048545;GO:0032502;GO:0031328;GO:0043933;GO:0031326;GO:0071383;GO:0031323;GO:0006807;GO:0090304;GO:0045682;GO:0007275;GO:0045684;GO:0009888;GO:0030522;GO:0030521;GO:0006325;GO:0033993;GO:1901360;GO:2000112;GO:0010557;GO:1903508;GO:0071704;GO:0010467;GO:0006357;GO:0045606;GO:0045604;GO:0010469;GO:0010468;GO:0043588;GO:0006351;GO:0060429;GO:0045935;GO:0043543;GO:0019219;GO:0006725;GO:0032355;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:1903506;GO:0051173;GO:0043627;GO:0007154;GO:0006996;GO:0044238;GO:0044260;GO:0009913;GO:0048856;GO:0045595;GO:0044237;GO:1902589;GO:2000026;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;protein acetylation;regulation of RNA biosynthetic process;signal transduction;organic substance biosynthetic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;RNA biosynthetic process;hormone-mediated signaling pathway;cellular response to stimulus;positive regulation of macromolecule metabolic process;regulation of signal transduction;cellular developmental process;cellular response to estrogen stimulus;peptidyl-amino acid modification;animal organ development;positive regulation of molecular function;epithelial cell differentiation;positive regulation of biological process;positive regulation of epithelial cell differentiation;histone modification;histone acetylation;keratinocyte differentiation;regulation of macromolecule metabolic process;internal protein amino acid acetylation;transcription from RNA polymerase II promoter;cellular macromolecule biosynthetic process;intracellular steroid hormone receptor signaling pathway;response to organic substance;heterocycle metabolic process;single organism signaling;single-multicellular organism process;protein metabolic process;regulation of nitrogen compound metabolic process;peptidyl-lysine modification;cellular response to organic cyclic compound;aromatic compound biosynthetic process;covalent chromatin modification;positive regulation of receptor activity;positive regulation of metabolic process;positive regulation of biosynthetic process;regulation of signaling;positive regulation of gene expression;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;regulation of cell communication;cellular component organization;biological regulation;response to organic cyclic compound;positive regulation of transcription from RNA polymerase II promoter;regulation of molecular function;heterocycle biosynthetic process;internal peptidyl-lysine acetylation;receptor transactivation;peptidyl-lysine acetylation;regulation of developmental process;regulation of biosynthetic process;single-organism metabolic process;cellular response to organic substance;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;regulation of cellular process;regulation of keratinocyte differentiation;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;steroid hormone mediated signaling pathway;regulation of macromolecule biosynthetic process;chromatin modification;response to alcohol;positive regulation of multicellular organismal process;cellular response to alcohol;regulation of multicellular organismal process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;epidermis development;single-organism process;response to endogenous stimulus;nucleobase-containing compound metabolic process;regulation of epithelial cell differentiation;positive regulation of cellular metabolic process;cellular response to endogenous stimulus;response to oxygen-containing compound;multicellular organismal process;cellular response to oxygen-containing compound;cellular response to estradiol stimulus;cellular process;cellular response to lipid;regulation of response to stimulus;positive regulation of cell differentiation;cellular response to hormone stimulus;positive regulation of transcription, DNA-templated;chromosome organization;positive regulation of developmental process;response to hormone;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of keratinocyte differentiation;system development;response to steroid hormone;developmental process;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;cellular response to steroid hormone stimulus;regulation of cellular metabolic process;nitrogen compound metabolic process;nucleic acid metabolic process;regulation of epidermis development;multicellular organism development;positive regulation of epidermis development;tissue development;intracellular receptor signaling pathway;androgen receptor signaling pathway;chromatin organization;response to lipid;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;positive regulation of nucleic acid-templated transcription;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;positive regulation of epidermal cell differentiation;regulation of epidermal cell differentiation;regulation of receptor activity;regulation of gene expression;skin development;transcription, DNA-templated;epithelium development;positive regulation of nucleobase-containing compound metabolic process;protein acylation;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;response to estradiol;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nucleic acid-templated transcription;positive regulation of nitrogen compound metabolic process;response to estrogen;cell communication;organelle organization;primary metabolic process;cellular macromolecule metabolic process;epidermal cell differentiation;anatomical structure development;regulation of cell differentiation;cellular metabolic process;single-organism organelle organization;regulation of multicellular organismal development;positive regulation of cellular process; 4;3;8;6;4;4;5;2;6;5;3;4;4;4;7;7;4;4;6;2;5;4;5;6;4;9;7;5;6;4;4;3;3;4;4;8;6;5;7;5;3;4;3;5;4;2;7;5;4;3;2;5;7;3;5;10;6;9;3;4;3;5;5;5;1;2;5;3;7;5;5;2;6;6;5;6;5;3;6;3;5;4;4;2;4;3;6;2;3;4;5;4;4;4;2;5;7;2;6;3;4;5;6;5;3;4;5;5;6;6;4;5;2;5;4;5;6;4;3;5;5;4;4;4;5;7;5;5;4;6;5;7;3;5;7;5;6;4;5;5;6;5;5;7;5;4;6;6;3;3;5;3;7;4;6;4;4;3;4;7;3;4;3;4;4;3; GO:0031981;GO:0000790;GO:0031974;GO:0043230;GO:0043231;GO:0043233;GO:0005694;GO:0044428;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0043232;GO:0043229;GO:0000228;GO:0043227;GO:0005654;GO:0005737;GO:0031982;GO:0044446;GO:0005634;GO:0044454;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0070062;GO:0043226;GO:0000785;GO:1903561;GO:0032991;GO:0005575;GO:0070013;GO:0005576; nuclear lumen;nuclear chromatin;membrane-enclosed lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;chromosome;nuclear part;intracellular part;chromosomal part;extracellular region part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;nuclear chromosome;membrane-bounded organelle;nucleoplasm;cytoplasm;vesicle;intracellular organelle part;nucleus;nuclear chromosome part;cell part;cell;intracellular;non-membrane-bounded organelle;extracellular exosome;organelle;chromatin;extracellular vesicle;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 5;4;2;3;4;3;5;4;3;4;2;2;4;3;5;3;5;4;4;3;5;5;2;2;3;3;4;2;3;3;2;1;4;2; GO:0050681;GO:0061733;GO:0034212;GO:0004402;GO:0003712;GO:0016740;GO:0016746;GO:0016747;GO:0046966;GO:0003674;GO:0005488;GO:0008080;GO:0000989;GO:0000988;GO:0035258;GO:0035257;GO:0003824;GO:0030374;GO:0003713;GO:0016410;GO:0008134;GO:0051427;GO:0016922;GO:0047485;GO:0016407;GO:0005515;GO:0005102; androgen receptor binding;peptide-lysine-N-acetyltransferase activity;peptide N-acetyltransferase activity;histone acetyltransferase activity;transcription cofactor activity;transferase activity;transferase activity, transferring acyl groups;transferase activity, transferring acyl groups other than amino-acyl groups;thyroid hormone receptor binding;molecular_function;binding;N-acetyltransferase activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;steroid hormone receptor binding;nuclear hormone receptor binding;catalytic activity;ligand-dependent nuclear receptor transcription coactivator activity;transcription coactivator activity;N-acyltransferase activity;transcription factor binding;hormone receptor binding;ligand-dependent nuclear receptor binding;protein N-terminus binding;acetyltransferase activity;protein binding;receptor binding; 8;9;8;10;4;3;4;5;5;1;2;7;3;2;7;6;2;6;5;6;4;5;5;4;6;3;4; K11256 map04919; Thyroid hormone signaling pathway; IPR017426;IPR010011;IPR014920;IPR015943;IPR013767;IPR011598;IPR014935;IPR000014;IPR028818;IPR009110;IPR032565; Nuclear receptor coactivator;Domain of unknown function DUF1518;Nuclear receptor coactivator, Ncoa-type, interlocking;WD40/YVTN repeat-like-containing domain;PAS fold;Myc-type, basic helix-loop-helix (bHLH) domain;Nuclear receptor coactivator, receptor-binding domain;PAS domain;Nuclear receptor coactivator 3;Nuclear receptor coactivator, interlocking;Domain of unknown function DUF4927; nucleus Hs5729726 2842.0 K [K] Transcription; Q15431 Synaptonemal complex protein 1 OS=Homo sapiens OX=9606 GN=SYCP1 PE=1 SV=2 - [SYCP1_HUMAN] 1.235 1.127 0.67 1.236 1.057 0.884 1.095829636 nan 1.169347209 nan 0.594498669 nan 0.836329234 nan GO:0008104;GO:0007286;GO:0048468;GO:1901362;GO:1901360;GO:0044710;GO:0044711;GO:0000003;GO:0048869;GO:0045132;GO:0048515;GO:0051704;GO:0006281;GO:0045143;GO:0007281;GO:0007283;GO:0007289;GO:0046483;GO:0044703;GO:0044702;GO:0000711;GO:0033554;GO:0019438;GO:0071103;GO:0022607;GO:0006807;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0051878;GO:0018130;GO:0051716;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0007059;GO:0070193;GO:0070192;GO:0050896;GO:0035092;GO:0000731;GO:0000280;GO:0030154;GO:0019953;GO:0044249;GO:0034641;GO:0034645;GO:0032879;GO:0007049;GO:0032880;GO:0006139;GO:0007126;GO:0007127;GO:0051321;GO:0007129;GO:0032502;GO:0006310;GO:0032501;GO:0048609;GO:0032504;GO:0006997;GO:0009987;GO:0006725;GO:0006974;GO:0048232;GO:0044271;GO:0007131;GO:0007130;GO:0044699;GO:0033036;GO:0098813;GO:0043170;GO:0051026;GO:0071897;GO:0043933;GO:1903046;GO:0090304;GO:0022402;GO:0007276;GO:0051179;GO:0006325;GO:0006323;GO:0050789;GO:0071704;GO:0051301;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0022412;GO:0006996;GO:0044238;GO:0051276;GO:0003006;GO:0048856;GO:0044237;GO:1902589;GO:0044085;GO:0048285;GO:0006259;GO:0035825; protein localization;spermatid development;cell development;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;reproduction;cellular developmental process;meiotic chromosome segregation;spermatid differentiation;multi-organism process;DNA repair;homologous chromosome segregation;germ cell development;spermatogenesis;spermatid nucleus differentiation;heterocycle metabolic process;multi-organism reproductive process;single organism reproductive process;meiotic DNA repair synthesis;cellular response to stress;aromatic compound biosynthetic process;DNA conformation change;cellular component assembly;nitrogen compound metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;lateral element assembly;heterocycle biosynthetic process;cellular response to stimulus;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;chromosome segregation;synaptonemal complex organization;chromosome organization involved in meiotic cell cycle;response to stimulus;sperm chromatin condensation;DNA synthesis involved in DNA repair;nuclear division;cell differentiation;sexual reproduction;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;regulation of localization;cell cycle;regulation of protein localization;nucleobase-containing compound metabolic process;meiotic nuclear division;meiosis I;meiotic cell cycle;synapsis;developmental process;DNA recombination;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;nucleus organization;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;male gamete generation;cellular nitrogen compound biosynthetic process;reciprocal meiotic recombination;synaptonemal complex assembly;single-organism process;macromolecule localization;nuclear chromosome segregation;macromolecule metabolic process;chiasma assembly;DNA biosynthetic process;macromolecular complex subunit organization;meiotic cell cycle process;nucleic acid metabolic process;cell cycle process;gamete generation;localization;chromatin organization;DNA packaging;regulation of biological process;organic substance metabolic process;cell division;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cellular process involved in reproduction in multicellular organism;organelle organization;primary metabolic process;chromosome organization;developmental process involved in reproduction;anatomical structure development;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;organelle fission;DNA metabolic process;reciprocal DNA recombination; 4;5;4;5;4;3;4;2;4;5;4;2;4;6;4;6;5;4;3;3;5;4;5;6;4;3;4;4;3;2;2;5;5;3;3;1;2;5;4;6;4;2;4;5;6;5;3;4;4;5;3;4;4;4;4;5;3;5;2;6;2;3;3;5;2;4;5;5;5;4;5;2;3;5;4;5;6;4;4;5;4;4;2;5;7;2;3;4;3;2;3;5;3;4;4;3;5;3;3;3;4;3;5;5;7; GO:0031974;GO:0031981;GO:0000793;GO:0000794;GO:0000795;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0000228;GO:0005622;GO:0043227;GO:0043226;GO:0001673;GO:0098687;GO:0044446;GO:0005634;GO:0000802;GO:0000801;GO:0044454;GO:0044464;GO:0005623;GO:0043228;GO:0043073;GO:0005694;GO:0000775;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;condensed chromosome;condensed nuclear chromosome;synaptonemal complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;nuclear chromosome;intracellular;membrane-bounded organelle;organelle;male germ cell nucleus;chromosomal region;intracellular organelle part;nucleus;transverse filament;central element;nuclear chromosome part;cell part;cell;non-membrane-bounded organelle;germ cell nucleus;chromosome;chromosome, centromeric region;cellular_component;intracellular organelle lumen; 2;5;6;6;6;4;4;3;4;3;4;2;3;5;3;3;2;7;5;3;5;6;6;5;2;2;3;6;5;6;1;4; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding; 3;1;2;4;5;3; K19533 IPR024835;IPR008827; Synaptonemal complex protein 1/2;Synaptonemal complex protein 1; nucleus O75179 Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3 - [ANR17_HUMAN] 0.917 0.795 1.295 0.99 1.047 1.218 1.15345912 0.01630001 0.945558739 0.962453284 1.628930818 1.78E-08 1.163323782 0.002142002 GO:0050688;GO:0019222;GO:0048584;GO:0048583;GO:0031349;GO:0072359;GO:0072358;GO:0007165;GO:0031347;GO:0080090;GO:0051716;GO:0045787;GO:0043207;GO:0009966;GO:0009615;GO:0044419;GO:0006260;GO:0048869;GO:0048518;GO:0002682;GO:0046483;GO:0039529;GO:0043123;GO:0098586;GO:0051052;GO:0060255;GO:0000082;GO:0051707;GO:0071695;GO:0051704;GO:0044700;GO:0009607;GO:0044707;GO:0009605;GO:0022402;GO:0006275;GO:0002376;GO:0042692;GO:0007249;GO:1901992;GO:0002831;GO:0002833;GO:0008152;GO:0006807;GO:0042742;GO:0035556;GO:0043170;GO:0021700;GO:0050789;GO:0000278;GO:1901576;GO:0007346;GO:0002764;GO:0044260;GO:0001568;GO:0002684;GO:0065007;GO:1901360;GO:0050793;GO:0009889;GO:0050794;GO:0006952;GO:1901987;GO:0043900;GO:0039528;GO:0051239;GO:0006955;GO:1902533;GO:1902531;GO:1901989;GO:0044843;GO:0043902;GO:0002757;GO:0051607;GO:0002753;GO:0050896;GO:0002758;GO:0006950;GO:0002218;GO:0002697;GO:0009059;GO:0009967;GO:0008150;GO:0002699;GO:0009617;GO:0032103;GO:0032101;GO:0010564;GO:0030154;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:1901990;GO:0034645;GO:0023051;GO:0061061;GO:0010647;GO:0010646;GO:0044699;GO:0006139;GO:0051240;GO:0001944;GO:0002221;GO:0032502;GO:0032501;GO:0044238;GO:0009987;GO:0006725;GO:0045596;GO:0045595;GO:0051151;GO:0098542;GO:0048519;GO:0016032;GO:0051093;GO:0044770;GO:0007049;GO:0050776;GO:2000045;GO:0001955;GO:0051726;GO:0050778;GO:0001816;GO:0001817;GO:0043122;GO:0048731;GO:0080134;GO:0001819;GO:0031326;GO:0031323;GO:1903047;GO:0090304;GO:0044772;GO:0051145;GO:0051147;GO:0051148;GO:0007275;GO:1902806;GO:0030522;GO:1900246;GO:1900245;GO:2000112;GO:0071704;GO:0010556;GO:1900087;GO:0045931;GO:0045089;GO:0045088;GO:0090068;GO:0019219;GO:0045087;GO:0044767;GO:0009058;GO:0044764;GO:0044763;GO:0051171;GO:0007154;GO:0039533;GO:0039530;GO:0039531;GO:0039535;GO:0048856;GO:0051150;GO:0044237;GO:1902808;GO:0002253;GO:0002252;GO:0006259;GO:0044403;GO:0048523;GO:0048522; regulation of defense response to virus;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;circulatory system development;cardiovascular system development;signal transduction;regulation of defense response;regulation of primary metabolic process;cellular response to stimulus;positive regulation of cell cycle;response to external biotic stimulus;regulation of signal transduction;response to virus;interspecies interaction between organisms;DNA replication;cellular developmental process;positive regulation of biological process;regulation of immune system process;heterocycle metabolic process;RIG-I signaling pathway;positive regulation of I-kappaB kinase/NF-kappaB signaling;cellular response to virus;regulation of DNA metabolic process;regulation of macromolecule metabolic process;G1/S transition of mitotic cell cycle;response to other organism;anatomical structure maturation;multi-organism process;single organism signaling;response to biotic stimulus;single-multicellular organism process;response to external stimulus;cell cycle process;regulation of DNA replication;immune system process;muscle cell differentiation;I-kappaB kinase/NF-kappaB signaling;positive regulation of mitotic cell cycle phase transition;regulation of response to biotic stimulus;positive regulation of response to biotic stimulus;metabolic process;nitrogen compound metabolic process;defense response to bacterium;intracellular signal transduction;macromolecule metabolic process;developmental maturation;regulation of biological process;mitotic cell cycle;organic substance biosynthetic process;regulation of mitotic cell cycle;immune response-regulating signaling pathway;cellular macromolecule metabolic process;blood vessel development;positive regulation of immune system process;biological regulation;organic cyclic compound metabolic process;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;defense response;regulation of cell cycle phase transition;regulation of multi-organism process;cytoplasmic pattern recognition receptor signaling pathway in response to virus;regulation of multicellular organismal process;immune response;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;positive regulation of cell cycle phase transition;cell cycle G1/S phase transition;positive regulation of multi-organism process;immune response-activating signal transduction;defense response to virus;cytoplasmic pattern recognition receptor signaling pathway;response to stimulus;innate immune response-activating signal transduction;response to stress;activation of innate immune response;regulation of immune effector process;macromolecule biosynthetic process;positive regulation of signal transduction;biological_process;positive regulation of immune effector process;response to bacterium;positive regulation of response to external stimulus;regulation of response to external stimulus;regulation of cell cycle process;cell differentiation;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of mitotic cell cycle phase transition;cellular macromolecule biosynthetic process;regulation of signaling;muscle structure development;positive regulation of cell communication;regulation of cell communication;single-organism process;nucleobase-containing compound metabolic process;positive regulation of multicellular organismal process;vasculature development;pattern recognition receptor signaling pathway;developmental process;multicellular organismal process;primary metabolic process;cellular process;cellular aromatic compound metabolic process;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of smooth muscle cell differentiation;defense response to other organism;negative regulation of biological process;viral process;negative regulation of developmental process;cell cycle phase transition;cell cycle;regulation of immune response;regulation of G1/S transition of mitotic cell cycle;blood vessel maturation;regulation of cell cycle;positive regulation of immune response;cytokine production;regulation of cytokine production;regulation of I-kappaB kinase/NF-kappaB signaling;system development;regulation of response to stress;positive regulation of cytokine production;regulation of cellular biosynthetic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;mitotic cell cycle phase transition;smooth muscle cell differentiation;regulation of muscle cell differentiation;negative regulation of muscle cell differentiation;multicellular organism development;regulation of cell cycle G1/S phase transition;intracellular receptor signaling pathway;positive regulation of RIG-I signaling pathway;positive regulation of MDA-5 signaling pathway;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;regulation of macromolecule biosynthetic process;positive regulation of G1/S transition of mitotic cell cycle;positive regulation of mitotic cell cycle;positive regulation of innate immune response;regulation of innate immune response;positive regulation of cell cycle process;regulation of nucleobase-containing compound metabolic process;innate immune response;single-organism developmental process;biosynthetic process;multi-organism cellular process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;regulation of MDA-5 signaling pathway;MDA-5 signaling pathway;regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway;regulation of RIG-I signaling pathway;anatomical structure development;regulation of smooth muscle cell differentiation;cellular metabolic process;positive regulation of cell cycle G1/S phase transition;activation of immune response;immune effector process;DNA metabolic process;symbiosis, encompassing mutualism through parasitism;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;3;4;5;5;4;5;4;3;4;4;4;4;3;6;4;2;3;4;5;6;5;5;4;7;3;4;2;3;3;3;3;4;6;2;5;6;6;4;4;2;3;5;5;4;4;2;5;4;5;5;4;4;3;2;4;3;4;3;4;6;3;4;3;3;5;5;6;6;3;4;4;6;2;5;3;4;4;5;4;1;4;4;4;4;5;5;3;4;4;2;6;5;3;4;4;4;2;4;3;5;6;2;2;3;2;4;4;4;6;4;2;4;3;5;4;4;7;5;4;4;4;4;6;4;4;4;5;4;5;5;6;6;5;5;4;7;5;4;4;6;3;5;7;5;5;5;5;5;4;3;3;3;3;4;4;6;5;5;6;3;6;3;7;3;3;5;4;3;3; GO:0016020;GO:0043231;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0000785;GO:0044446;GO:0005634;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0043227;GO:0043226;GO:0005694;GO:0032991;GO:0005575;GO:0044427; membrane;intracellular membrane-bounded organelle;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;chromatin;intracellular organelle part;nucleus;cytoplasm;cell part;cell;intracellular;non-membrane-bounded organelle;membrane-bounded organelle;organelle;chromosome;macromolecular complex;cellular_component;chromosomal part; 2;4;3;2;4;3;3;3;5;4;2;2;3;3;3;2;5;2;1;4; GO:1901363;GO:0044877;GO:0005488;GO:0003676;GO:0003723;GO:0097159;GO:0044822;GO:0003682;GO:0003674; heterocyclic compound binding;macromolecular complex binding;binding;nucleic acid binding;RNA binding;organic cyclic compound binding;poly(A) RNA binding;chromatin binding;molecular_function; 3;3;2;4;5;3;6;4;1; K16726 IPR004087;IPR002110;IPR020683;IPR004088; K Homology domain;Ankyrin repeat;Ankyrin repeat-containing domain;K Homology domain, type 1; plasma membrane Hs13386462 770.0 R [R] General function prediction only; Q9BZS1 Forkhead box protein P3 OS=Homo sapiens OX=9606 GN=FOXP3 PE=1 SV=1 - [FOXP3_HUMAN] 1.002 0.996 0.372 2.373 0.627 1.756 1.006024096 nan 3.784688995 nan 0.373493976 nan 2.800637959 nan GO:0051046;GO:0051048;GO:0051049;GO:0002707;GO:0002706;GO:0002705;GO:0002704;GO:0042035;GO:0002701;GO:0042036;GO:0002709;GO:0002708;GO:0051716;GO:0043207;GO:0071604;GO:0002361;GO:0006473;GO:0002363;GO:0006475;GO:0002824;GO:0002362;GO:0002822;GO:0002823;GO:0002820;GO:0002821;GO:0002677;GO:0002676;GO:0046483;GO:0065008;GO:0009607;GO:0042089;GO:0009605;GO:0019538;GO:0071594;GO:0010638;GO:0010639;GO:0002703;GO:0045829;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0002700;GO:0032792;GO:0051254;GO:0046651;GO:0051223;GO:0051224;GO:0050789;GO:2000398;GO:0032700;GO:0002684;GO:0032703;GO:0002682;GO:0071840;GO:1903308;GO:1903309;GO:0045910;GO:0018130;GO:0070201;GO:0098602;GO:0033077;GO:0098609;GO:0043412;GO:0002521;GO:0002520;GO:0016070;GO:0002293;GO:0002292;GO:0002294;GO:0010557;GO:0036211;GO:2001252;GO:0010558;GO:2001251;GO:0032609;GO:0051129;GO:0051128;GO:0098732;GO:0000122;GO:0045076;GO:0045077;GO:0045072;GO:0045621;GO:0045620;GO:0045623;GO:0045622;GO:0032674;GO:0032675;GO:0008284;GO:0008285;GO:0035601;GO:0008283;GO:0050870;GO:0002637;GO:0002638;GO:0006338;GO:0002870;GO:0060341;GO:0042592;GO:0022407;GO:0032635;GO:0015031;GO:0007275;GO:0022408;GO:0022409;GO:0002643;GO:0002645;GO:2000112;GO:2000113;GO:0070661;GO:0070663;GO:0032714;GO:0070665;GO:0070664;GO:0045785;GO:0019219;GO:0032914;GO:0090311;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0033091;GO:0051276;GO:0048856;GO:0002698;GO:1902107;GO:1902106;GO:1902105;GO:2000026;GO:2000756;GO:2000757;GO:2000758;GO:0048523;GO:0048522;GO:0042130;GO:0033089;GO:0032620;GO:0034112;GO:0034111;GO:0034110;GO:0033080;GO:0033081;GO:0033083;GO:0033084;GO:0031348;GO:0007162;GO:0007165;GO:0007166;GO:0002458;GO:0002456;GO:0031347;GO:0002517;GO:0044710;GO:0002513;GO:0032693;GO:0002260;GO:0002262;GO:0002263;GO:0050727;GO:0048294;GO:0048293;GO:0048291;GO:0044092;GO:0033036;GO:0051053;GO:0051052;GO:0051051;GO:0030217;GO:0032905;GO:1903708;GO:2001141;GO:1903706;GO:1903707;GO:0051704;GO:0002429;GO:0018205;GO:0000018;GO:0016445;GO:0016444;GO:0016568;GO:0016569;GO:0045321;GO:0010629;GO:0006807;GO:0042093;GO:0044267;GO:0002764;GO:0044260;GO:0042094;GO:0002768;GO:0042098;GO:0045085;GO:0050708;GO:0006366;GO:0050798;GO:0050793;GO:0009889;GO:0050794;GO:0002889;GO:0051249;GO:0051239;GO:0051234;GO:1902679;GO:0050896;GO:0009058;GO:0032088;GO:0002695;GO:0002694;GO:0002697;GO:0002696;GO:0032713;GO:0002699;GO:1903310;GO:0033044;GO:0048302;GO:0032102;GO:0072539;GO:0033043;GO:0051173;GO:1903531;GO:1903530;GO:0032829;GO:0044699;GO:0032880;GO:0051248;GO:0016064;GO:0051240;GO:0051241;GO:0051246;GO:0051247;GO:1903038;GO:1903039;GO:0031399;GO:0001782;GO:1903034;GO:1903035;GO:1903037;GO:0032613;GO:2000516;GO:2000514;GO:2000515;GO:0051707;GO:0002465;GO:0045066;GO:0002460;GO:0002461;GO:0002544;GO:1902680;GO:0045619;GO:0048731;GO:0032663;GO:0032660;GO:0016337;GO:0050868;GO:0050865;GO:0050864;GO:0050867;GO:0050866;GO:0050863;GO:0002725;GO:0002724;GO:0006325;GO:0045935;GO:0045934;GO:0032753;GO:0070489;GO:0070486;GO:0002849;GO:0006996;GO:0044238;GO:0002652;GO:0002654;GO:0002658;GO:0044237;GO:0006259;GO:0009306;GO:0032623;GO:2000320;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0006476;GO:0008104;GO:0031057;GO:0031056;GO:0031058;GO:0002381;GO:1901362;GO:1901360;GO:0035065;GO:2000400;GO:0046639;GO:0048869;GO:0046638;GO:0048513;GO:0048518;GO:0048519;GO:0046635;GO:0032720;GO:0002683;GO:0042127;GO:0032653;GO:0033092;GO:0042129;GO:0045184;GO:0051090;GO:0007155;GO:0043433;GO:0044700;GO:0002507;GO:0044707;GO:0002376;GO:0002377;GO:0046006;GO:0046007;GO:0043170;GO:0097659;GO:0043543;GO:0045058;GO:0016575;GO:0033079;GO:0002208;GO:0016570;GO:0016573;GO:0002200;GO:0002204;GO:0018393;GO:0018394;GO:0006810;GO:0050728;GO:0006952;GO:0001776;GO:0001775;GO:0006954;GO:0006955;GO:0034654;GO:0002660;GO:0046903;GO:0002757;GO:0044271;GO:0031400;GO:0031401;GO:0006950;GO:0006355;GO:0006357;GO:0006351;GO:0050671;GO:0009611;GO:0035710;GO:0032774;GO:0030155;GO:0030154;GO:0002669;GO:0045580;GO:0045581;GO:0045582;GO:0045589;GO:1904950;GO:0002890;GO:0006139;GO:0043933;GO:0043368;GO:0043369;GO:0032270;GO:0032673;GO:0043367;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0050710;GO:0032879;GO:0050777;GO:0050776;GO:0051251;GO:0051250;GO:0051253;GO:0051252;GO:0050670;GO:0050778;GO:0050672;GO:0001816;GO:0001817;GO:0080134;GO:0001818;GO:0001819;GO:1902275;GO:0042113;GO:0042110;GO:0032101;GO:0071704;GO:0010556;GO:0071702;GO:0032715;GO:0002249;GO:0050851;GO:0050852;GO:0002710;GO:0002711;GO:0002712;GO:0009059;GO:0051171;GO:0051172;GO:0072538;GO:0002718;GO:0002719;GO:0051179;GO:1902578;GO:0051641;GO:0006310;GO:1902589;GO:0071634;GO:0071636;GO:0080090;GO:0035066;GO:0035067;GO:0046637;GO:0046636;GO:0002851;GO:0046634;GO:0046632;GO:0046631;GO:0002664;GO:0002666;GO:0002667;GO:0010605;GO:0010604;GO:0009615;GO:0018193;GO:0019724;GO:0060255;GO:0032831;GO:0031064;GO:0046649;GO:0031063;GO:0048872;GO:0071706;GO:0019438;GO:0032640;GO:0045191;GO:0045190;GO:0032649;GO:0032943;GO:0032940;GO:0032946;GO:1903556;GO:0032944;GO:0032945;GO:1901576;GO:0002286;GO:0002287;GO:0002285;GO:0050707;GO:0016043;GO:2000319;GO:0002367;GO:0002366;GO:0065007;GO:0002360;GO:0065009;GO:0071593;GO:0002369;GO:2000316;GO:2000317;GO:0051130;GO:1901984;GO:1901985;GO:0008150;GO:1901983;GO:0008152;GO:0042102;GO:0045165;GO:0016447;GO:0002819;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007154;GO:0009653;GO:0002911;GO:0043029;GO:0022610;GO:0045597;GO:0045596;GO:0045595;GO:0045892;GO:0045893;GO:0045591;GO:0051093;GO:0032269;GO:0032268;GO:0051094;GO:0010628;GO:0045944;GO:0030098;GO:0043371;GO:0043370;GO:0043373;GO:0043372;GO:1903508;GO:1903555;GO:0032908;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0050663;GO:0010467;GO:0048534;GO:0010468;GO:0032634;GO:0034109;GO:0042107;GO:0032633;GO:0002449;GO:0007159;GO:0002440;GO:0002913;GO:0050869;GO:0002443;GO:0050709;GO:0002562;GO:0042095;GO:0002713;GO:0030097;GO:0032680;GO:0002250;GO:0002253;GO:0002252;GO:0032689;GO:0048289;GO:0002312; regulation of secretion;negative regulation of secretion;regulation of transport;negative regulation of lymphocyte mediated immunity;regulation of lymphocyte mediated immunity;positive regulation of leukocyte mediated immunity;negative regulation of leukocyte mediated immunity;regulation of cytokine biosynthetic process;negative regulation of production of molecular mediator of immune response;negative regulation of cytokine biosynthetic process;regulation of T cell mediated immunity;positive regulation of lymphocyte mediated immunity;cellular response to stimulus;response to external biotic stimulus;transforming growth factor beta production;CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;protein acetylation;alpha-beta T cell lineage commitment;internal protein amino acid acetylation;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;negative regulation of adaptive immune response;positive regulation of adaptive immune response;negative regulation of chronic inflammatory response;regulation of chronic inflammatory response;heterocycle metabolic process;regulation of biological quality;response to biotic stimulus;cytokine biosynthetic process;response to external stimulus;protein metabolic process;thymocyte aggregation;positive regulation of organelle organization;negative regulation of organelle organization;regulation of leukocyte mediated immunity;negative regulation of isotype switching;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;regulation of production of molecular mediator of immune response;negative regulation of CREB transcription factor activity;positive regulation of RNA metabolic process;lymphocyte proliferation;regulation of protein transport;negative regulation of protein transport;regulation of biological process;regulation of thymocyte aggregation;negative regulation of interleukin-17 production;positive regulation of immune system process;negative regulation of interleukin-2 production;regulation of immune system process;cellular component organization or biogenesis;regulation of chromatin modification;negative regulation of chromatin modification;negative regulation of DNA recombination;heterocycle biosynthetic process;regulation of establishment of protein localization;single organism cell adhesion;T cell differentiation in thymus;cell-cell adhesion;macromolecule modification;leukocyte differentiation;immune system development;RNA metabolic process;alpha-beta T cell differentiation involved in immune response;T cell differentiation involved in immune response;CD4-positive, alpha-beta T cell differentiation involved in immune response;positive regulation of macromolecule biosynthetic process;protein modification process;positive regulation of chromosome organization;negative regulation of macromolecule biosynthetic process;negative regulation of chromosome organization;interferon-gamma production;negative regulation of cellular component organization;regulation of cellular component organization;macromolecule deacylation;negative regulation of transcription from RNA polymerase II promoter;regulation of interleukin-2 biosynthetic process;negative regulation of interferon-gamma biosynthetic process;regulation of interferon-gamma biosynthetic process;positive regulation of lymphocyte differentiation;negative regulation of lymphocyte differentiation;negative regulation of T-helper cell differentiation;regulation of T-helper cell differentiation;regulation of interleukin-5 production;regulation of interleukin-6 production;positive regulation of cell proliferation;negative regulation of cell proliferation;protein deacylation;cell proliferation;positive regulation of T cell activation;regulation of immunoglobulin production;negative regulation of immunoglobulin production;chromatin remodeling;T cell anergy;regulation of cellular localization;homeostatic process;regulation of cell-cell adhesion;interleukin-6 production;protein transport;multicellular organism development;negative regulation of cell-cell adhesion;positive regulation of cell-cell adhesion;regulation of tolerance induction;positive regulation of tolerance induction;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;leukocyte proliferation;regulation of leukocyte proliferation;negative regulation of interleukin-5 production;positive regulation of leukocyte proliferation;negative regulation of leukocyte proliferation;positive regulation of cell adhesion;regulation of nucleobase-containing compound metabolic process;positive regulation of transforming growth factor beta1 production;regulation of protein deacetylation;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;positive regulation of immature T cell proliferation;chromosome organization;anatomical structure development;negative regulation of immune effector process;positive regulation of leukocyte differentiation;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;regulation of peptidyl-lysine acetylation;negative regulation of peptidyl-lysine acetylation;positive regulation of peptidyl-lysine acetylation;negative regulation of cellular process;positive regulation of cellular process;negative regulation of T cell proliferation;positive regulation of T cell differentiation in thymus;interleukin-17 production;positive regulation of homotypic cell-cell adhesion;negative regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;immature T cell proliferation in thymus;regulation of T cell differentiation in thymus;regulation of immature T cell proliferation;regulation of immature T cell proliferation in thymus;negative regulation of defense response;negative regulation of cell adhesion;signal transduction;cell surface receptor signaling pathway;peripheral T cell tolerance induction;T cell mediated immunity;regulation of defense response;T cell tolerance induction;single-organism metabolic process;tolerance induction to self antigen;negative regulation of interleukin-10 production;lymphocyte homeostasis;myeloid cell homeostasis;cell activation involved in immune response;regulation of inflammatory response;negative regulation of isotype switching to IgE isotypes;regulation of isotype switching to IgE isotypes;isotype switching to IgG isotypes;negative regulation of molecular function;macromolecule localization;negative regulation of DNA metabolic process;regulation of DNA metabolic process;negative regulation of transport;T cell differentiation;transforming growth factor beta1 production;positive regulation of hemopoiesis;regulation of RNA biosynthetic process;regulation of hemopoiesis;negative regulation of hemopoiesis;multi-organism process;immune response-activating cell surface receptor signaling pathway;peptidyl-lysine modification;regulation of DNA recombination;somatic diversification of immunoglobulins;somatic cell DNA recombination;chromatin modification;covalent chromatin modification;leukocyte activation;negative regulation of gene expression;nitrogen compound metabolic process;T-helper cell differentiation;cellular protein metabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;interleukin-2 biosynthetic process;immune response-regulating cell surface receptor signaling pathway;T cell proliferation;negative regulation of interleukin-2 biosynthetic process;regulation of protein secretion;transcription from RNA polymerase II promoter;activated T cell proliferation;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;regulation of immunoglobulin mediated immune response;regulation of lymphocyte activation;regulation of multicellular organismal process;establishment of localization;negative regulation of RNA biosynthetic process;response to stimulus;biosynthetic process;negative regulation of NF-kappaB transcription factor activity;negative regulation of leukocyte activation;regulation of leukocyte activation;regulation of immune effector process;positive regulation of leukocyte activation;negative regulation of interleukin-4 production;positive regulation of immune effector process;positive regulation of chromatin modification;regulation of chromosome organization;regulation of isotype switching to IgG isotypes;negative regulation of response to external stimulus;T-helper 17 cell differentiation;regulation of organelle organization;positive regulation of nitrogen compound metabolic process;negative regulation of secretion by cell;regulation of secretion by cell;regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;single-organism process;regulation of protein localization;negative regulation of protein metabolic process;immunoglobulin mediated immune response;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;negative regulation of leukocyte cell-cell adhesion;positive regulation of leukocyte cell-cell adhesion;regulation of protein modification process;B cell homeostasis;regulation of response to wounding;negative regulation of response to wounding;regulation of leukocyte cell-cell adhesion;interleukin-10 production;positive regulation of CD4-positive, alpha-beta T cell activation;regulation of CD4-positive, alpha-beta T cell activation;negative regulation of CD4-positive, alpha-beta T cell activation;response to other organism;peripheral tolerance induction;regulatory T cell differentiation;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;tolerance induction dependent upon immune response;chronic inflammatory response;positive regulation of RNA biosynthetic process;regulation of lymphocyte differentiation;system development;regulation of interleukin-2 production;regulation of interleukin-17 production;single organismal cell-cell adhesion;negative regulation of T cell activation;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;negative regulation of cell activation;regulation of T cell activation;negative regulation of T cell cytokine production;regulation of T cell cytokine production;chromatin organization;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;positive regulation of interleukin-4 production;T cell aggregation;leukocyte aggregation;regulation of peripheral T cell tolerance induction;organelle organization;primary metabolic process;regulation of tolerance induction dependent upon immune response;positive regulation of tolerance induction dependent upon immune response;regulation of peripheral tolerance induction;cellular metabolic process;DNA metabolic process;protein secretion;interleukin-2 production;negative regulation of T-helper 17 cell differentiation;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;protein deacetylation;protein localization;negative regulation of histone modification;regulation of histone modification;positive regulation of histone modification;immunoglobulin production involved in immunoglobulin mediated immune response;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of histone acetylation;positive regulation of thymocyte aggregation;negative regulation of alpha-beta T cell differentiation;cellular developmental process;positive regulation of alpha-beta T cell differentiation;animal organ development;positive regulation of biological process;negative regulation of biological process;positive regulation of alpha-beta T cell activation;negative regulation of tumor necrosis factor production;negative regulation of immune system process;regulation of cell proliferation;regulation of interleukin-10 production;positive regulation of immature T cell proliferation in thymus;regulation of T cell proliferation;establishment of protein localization;regulation of sequence-specific DNA binding transcription factor activity;cell adhesion;negative regulation of sequence-specific DNA binding transcription factor activity;single organism signaling;tolerance induction;single-multicellular organism process;immune system process;immunoglobulin production;regulation of activated T cell proliferation;negative regulation of activated T cell proliferation;macromolecule metabolic process;nucleic acid-templated transcription;protein acylation;T cell selection;histone deacetylation;immature T cell proliferation;somatic diversification of immunoglobulins involved in immune response;histone modification;histone acetylation;somatic diversification of immune receptors;somatic recombination of immunoglobulin genes involved in immune response;internal peptidyl-lysine acetylation;peptidyl-lysine acetylation;transport;negative regulation of inflammatory response;defense response;leukocyte homeostasis;cell activation;inflammatory response;immune response;nucleobase-containing compound biosynthetic process;positive regulation of peripheral tolerance induction;secretion;immune response-activating signal transduction;cellular nitrogen compound biosynthetic process;negative regulation of protein modification process;positive regulation of protein modification process;response to stress;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;positive regulation of lymphocyte proliferation;response to wounding;CD4-positive, alpha-beta T cell activation;RNA biosynthetic process;regulation of cell adhesion;cell differentiation;positive regulation of T cell anergy;regulation of T cell differentiation;negative regulation of T cell differentiation;positive regulation of T cell differentiation;regulation of regulatory T cell differentiation;negative regulation of establishment of protein localization;negative regulation of immunoglobulin mediated immune response;nucleobase-containing compound metabolic process;macromolecular complex subunit organization;positive T cell selection;CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;positive regulation of cellular protein metabolic process;regulation of interleukin-4 production;CD4-positive, alpha-beta T cell differentiation;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of cytokine secretion;regulation of localization;negative regulation of immune response;regulation of immune response;positive regulation of lymphocyte activation;negative regulation of lymphocyte activation;negative regulation of RNA metabolic process;regulation of RNA metabolic process;regulation of lymphocyte proliferation;positive regulation of immune response;negative regulation of lymphocyte proliferation;cytokine production;regulation of cytokine production;regulation of response to stress;negative regulation of cytokine production;positive regulation of cytokine production;regulation of chromatin organization;B cell activation;T cell activation;regulation of response to external stimulus;organic substance metabolic process;regulation of macromolecule biosynthetic process;organic substance transport;negative regulation of interleukin-6 production;lymphocyte anergy;antigen receptor-mediated signaling pathway;T cell receptor signaling pathway;negative regulation of T cell mediated immunity;positive regulation of T cell mediated immunity;regulation of B cell mediated immunity;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;T-helper 17 type immune response;regulation of cytokine production involved in immune response;negative regulation of cytokine production involved in immune response;localization;single-organism localization;cellular localization;DNA recombination;single-organism organelle organization;regulation of transforming growth factor beta production;positive regulation of transforming growth factor beta production;regulation of primary metabolic process;positive regulation of histone acetylation;negative regulation of histone acetylation;regulation of alpha-beta T cell differentiation;negative regulation of alpha-beta T cell activation;positive regulation of peripheral T cell tolerance induction;regulation of alpha-beta T cell activation;alpha-beta T cell differentiation;alpha-beta T cell activation;regulation of T cell tolerance induction;positive regulation of T cell tolerance induction;regulation of T cell anergy;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;response to virus;peptidyl-amino acid modification;B cell mediated immunity;regulation of macromolecule metabolic process;positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;negative regulation of histone deacetylation;lymphocyte activation;regulation of histone deacetylation;homeostasis of number of cells;tumor necrosis factor superfamily cytokine production;aromatic compound biosynthetic process;tumor necrosis factor production;regulation of isotype switching;isotype switching;regulation of interferon-gamma production;mononuclear cell proliferation;secretion by cell;positive regulation of mononuclear cell proliferation;negative regulation of tumor necrosis factor superfamily cytokine production;regulation of mononuclear cell proliferation;negative regulation of mononuclear cell proliferation;organic substance biosynthetic process;T cell activation involved in immune response;alpha-beta T cell activation involved in immune response;lymphocyte activation involved in immune response;regulation of cytokine secretion;cellular component organization;regulation of T-helper 17 cell differentiation;cytokine production involved in immune response;leukocyte activation involved in immune response;biological regulation;T cell lineage commitment;regulation of molecular function;lymphocyte aggregation;T cell cytokine production;regulation of T-helper 17 type immune response;negative regulation of T-helper 17 type immune response;positive regulation of cellular component organization;negative regulation of protein acetylation;positive regulation of protein acetylation;biological_process;regulation of protein acetylation;metabolic process;positive regulation of T cell proliferation;cell fate commitment;somatic recombination of immunoglobulin gene segments;regulation of adaptive immune response;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;anatomical structure morphogenesis;regulation of lymphocyte anergy;T cell homeostasis;biological adhesion;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;positive regulation of regulatory T cell differentiation;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;positive regulation of developmental process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;lymphocyte differentiation;negative regulation of CD4-positive, alpha-beta T cell differentiation;regulation of CD4-positive, alpha-beta T cell differentiation;CD4-positive, alpha-beta T cell lineage commitment;positive regulation of CD4-positive, alpha-beta T cell differentiation;positive regulation of nucleic acid-templated transcription;regulation of tumor necrosis factor superfamily cytokine production;regulation of transforming growth factor beta1 production;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cytokine secretion;gene expression;hematopoietic or lymphoid organ development;regulation of gene expression;interleukin-5 production;homotypic cell-cell adhesion;cytokine metabolic process;interleukin-4 production;lymphocyte mediated immunity;leukocyte cell-cell adhesion;production of molecular mediator of immune response;positive regulation of lymphocyte anergy;negative regulation of B cell activation;leukocyte mediated immunity;negative regulation of protein secretion;somatic diversification of immune receptors via germline recombination within a single locus;interferon-gamma biosynthetic process;negative regulation of B cell mediated immunity;hemopoiesis;regulation of tumor necrosis factor production;adaptive immune response;activation of immune response;immune effector process;negative regulation of interferon-gamma production;isotype switching to IgE isotypes;B cell activation involved in immune response; 5;4;4;6;6;5;5;5;4;5;7;6;3;4;5;8;8;7;9;6;7;6;6;5;5;6;6;4;3;3;5;3;4;5;5;5;5;4;3;3;4;4;4;6;5;5;5;4;2;5;5;3;5;3;2;7;7;6;5;5;3;6;4;5;6;3;5;4;4;4;5;5;6;5;6;5;4;4;6;7;5;6;6;6;6;5;5;5;5;4;4;7;3;6;5;5;7;5;4;4;5;5;5;4;5;5;4;4;6;6;4;5;5;5;5;4;5;6;7;6;3;4;3;8;5;3;4;5;5;5;4;8;8;8;3;3;7;6;5;6;6;6;6;6;8;7;4;4;4;5;5;6;5;4;3;4;5;4;3;4;5;5;6;5;4;3;5;5;3;6;6;4;6;4;4;2;5;8;6;4;7;6;7;3;5;3;5;5;5;4;4;6;6;5;6;7;7;3;4;3;8;5;3;3;6;2;3;6;4;4;4;4;5;4;7;6;6;4;6;5;4;4;5;9;2;4;5;7;3;3;5;5;6;6;6;5;5;4;6;5;8;8;8;3;5;7;5;4;6;6;6;4;5;5;4;6;4;6;4;4;6;6;6;5;5;5;5;4;6;6;4;3;5;5;6;3;5;5;5;6;3;3;3;3;8;4;5;5;5;5;5;4;6;5;8;4;8;4;2;2;7;6;3;4;5;7;7;4;4;3;5;3;3;3;2;4;8;8;4;7;7;3;5;7;5;4;5;3;6;10;9;4;5;4;3;4;5;3;5;6;5;4;5;6;6;3;6;7;6;6;4;7;6;4;5;6;7;7;7;8;3;8;4;4;4;5;5;5;8;2;2;2;4;7;7;5;3;4;4;5;5;5;5;6;4;6;4;4;4;4;4;6;5;5;4;3;5;5;5;4;6;7;7;7;7;5;4;4;6;5;5;2;3;3;6;4;5;5;4;6;6;8;7;6;7;7;6;5;5;6;4;4;4;7;6;4;9;6;4;6;5;5;5;6;5;4;5;5;4;6;5;6;6;4;4;4;4;5;3;6;4;4;2;6;3;7;5;7;7;4;7;7;1;7;2;7;5;5;5;4;4;2;5;4;3;5;5;2;4;4;4;6;6;8;3;5;5;3;5;7;5;9;9;6;9;7;5;6;5;5;5;4;4;4;5;5;5;4;5;5;5;5;5;5;5;3;5;6;4;5;4;6;7;5;6;4;3;3;5;5;4; GO:0044424;GO:0044464;GO:0043234;GO:0043231;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0005623;GO:0005622;GO:0032991;GO:0005575; intracellular part;cell part;protein complex;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;cell;intracellular;macromolecular complex;cellular_component; 3;2;3;4;3;3;2;4;5;2;3;2;1; GO:0044212;GO:0000981;GO:0005488;GO:0042826;GO:0000975;GO:0043565;GO:0001067;GO:0051059;GO:0046983;GO:0019899;GO:0051525;GO:0008134;GO:0005515;GO:0001047;GO:0003700;GO:0003705;GO:1901363;GO:0046872;GO:0003674;GO:0003676;GO:0003677;GO:0097159;GO:0043167;GO:0042802;GO:0042803;GO:0001071;GO:0003714;GO:0003712;GO:0000989;GO:0000988;GO:0043169;GO:0035035; transcription regulatory region DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;binding;histone deacetylase binding;regulatory region DNA binding;sequence-specific DNA binding;regulatory region nucleic acid binding;NF-kappaB binding;protein dimerization activity;enzyme binding;NFAT protein binding;transcription factor binding;protein binding;core promoter binding;transcription factor activity, sequence-specific DNA binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;heterocyclic compound binding;metal ion binding;molecular_function;nucleic acid binding;DNA binding;organic cyclic compound binding;ion binding;identical protein binding;protein homodimerization activity;nucleic acid binding transcription factor activity;transcription corepressor activity;transcription cofactor activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;cation binding;histone acetyltransferase binding; 7;4;2;5;6;6;5;5;4;4;5;4;3;8;3;5;3;5;1;4;5;3;3;4;5;2;5;4;3;2;4;5; K10163 map05321; Inflammatory bowel disease (IBD); IPR013087;IPR032354;IPR030456;IPR001766;IPR011991; Zinc finger C2H2-type;FOXP, coiled-coil domain;Fork head domain conserved site 2;Fork head domain;Winged helix-turn-helix DNA-binding domain; nucleus Hs7661846 656.0 K [K] Transcription; Q99459 Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2 - [CDC5L_HUMAN] 0.923 1.006 1.064 0.803 1.171 1.279 0.91749503 0.028349087 0.685738685 4.11E-05 1.057654076 0.084464005 1.092228864 0.183005781 GO:0080090;GO:0019222;GO:1990637;GO:0007165;GO:0048523;GO:1901362;GO:1901360;GO:0051716;GO:0045786;GO:0072422;GO:0070848;GO:0014070;GO:0065007;GO:0006281;GO:0060255;GO:2001141;GO:0043434;GO:0010033;GO:0046483;GO:0044700;GO:0010243;GO:0000398;GO:0010468;GO:0050789;GO:0033554;GO:0071407;GO:0019438;GO:0034645;GO:0035556;GO:0072401;GO:1901576;GO:0044260;GO:0071352;GO:0044344;GO:0019219;GO:0007049;GO:0018130;GO:0034097;GO:0009889;GO:0044710;GO:0050794;GO:1901987;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:1901988;GO:0016070;GO:0016071;GO:0044271;GO:0071345;GO:0050896;GO:1901699;GO:0006355;GO:0009059;GO:0006351;GO:0071774;GO:0072395;GO:0051171;GO:0032774;GO:1904567;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0007154;GO:0044699;GO:0009719;GO:0006139;GO:0071375;GO:0010564;GO:0008380;GO:0071495;GO:1901701;GO:0009987;GO:0006725;GO:1903506;GO:0006974;GO:0032870;GO:0048519;GO:0000077;GO:0044770;GO:0071363;GO:0000075;GO:0009725;GO:0051252;GO:0043170;GO:0006807;GO:1901698;GO:1990090;GO:0031326;GO:0031323;GO:0090304;GO:0010948;GO:0022402;GO:0010467;GO:0006396;GO:0071417;GO:2000112;GO:0071704;GO:0071310;GO:0010556;GO:0097659;GO:0070669;GO:0000278;GO:1990089;GO:0000375;GO:0009058;GO:0000377;GO:0044763;GO:1990646;GO:0042221;GO:0042770;GO:1901700;GO:0044238;GO:0031570;GO:0051726;GO:0044237;GO:1901654;GO:1901655;GO:1901652;GO:1901653;GO:1904568;GO:0006259;GO:0006397; regulation of primary metabolic process;regulation of metabolic process;response to prolactin;signal transduction;negative regulation of cellular process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of cell cycle;signal transduction involved in DNA damage checkpoint;response to growth factor;response to organic cyclic compound;biological regulation;DNA repair;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;response to peptide hormone;response to organic substance;heterocycle metabolic process;single organism signaling;response to organonitrogen compound;mRNA splicing, via spliceosome;regulation of gene expression;regulation of biological process;cellular response to stress;cellular response to organic cyclic compound;aromatic compound biosynthetic process;cellular macromolecule biosynthetic process;intracellular signal transduction;signal transduction involved in DNA integrity checkpoint;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular response to interleukin-2;cellular response to fibroblast growth factor stimulus;regulation of nucleobase-containing compound metabolic process;cell cycle;heterocycle biosynthetic process;response to cytokine;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;regulation of cell cycle phase transition;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;negative regulation of cell cycle phase transition;RNA metabolic process;mRNA metabolic process;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;cellular response to nitrogen compound;regulation of transcription, DNA-templated;macromolecule biosynthetic process;transcription, DNA-templated;response to fibroblast growth factor;signal transduction involved in cell cycle checkpoint;regulation of nitrogen compound metabolic process;RNA biosynthetic process;response to wortmannin;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;cell communication;single-organism process;response to endogenous stimulus;nucleobase-containing compound metabolic process;cellular response to peptide hormone stimulus;regulation of cell cycle process;RNA splicing;cellular response to endogenous stimulus;cellular response to oxygen-containing compound;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;cellular response to hormone stimulus;negative regulation of biological process;DNA damage checkpoint;cell cycle phase transition;cellular response to growth factor stimulus;cell cycle checkpoint;response to hormone;regulation of RNA metabolic process;macromolecule metabolic process;nitrogen compound metabolic process;response to nitrogen compound;cellular response to nerve growth factor stimulus;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;negative regulation of cell cycle process;cell cycle process;gene expression;RNA processing;cellular response to organonitrogen compound;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;regulation of macromolecule biosynthetic process;nucleic acid-templated transcription;response to interleukin-2;mitotic cell cycle;response to nerve growth factor;RNA splicing, via transesterification reactions;biosynthetic process;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;single-organism cellular process;cellular response to prolactin;response to chemical;signal transduction in response to DNA damage;response to oxygen-containing compound;primary metabolic process;DNA integrity checkpoint;regulation of cell cycle;cellular metabolic process;response to ketone;cellular response to ketone;response to peptide;cellular response to peptide;cellular response to wortmannin;DNA metabolic process;mRNA processing; 4;3;6;4;3;5;4;3;4;7;5;5;2;4;4;6;5;4;4;3;4;8;5;2;4;6;5;5;5;6;4;4;7;5;5;4;5;5;4;3;3;6;3;1;2;5;6;5;6;5;6;2;5;6;5;6;4;5;4;6;6;4;4;2;4;4;2;3;4;6;5;7;4;5;2;4;7;5;5;2;6;5;6;5;4;5;4;3;4;5;5;4;5;5;4;5;6;5;6;3;5;5;7;6;5;4;8;3;9;3;7;3;6;4;3;6;4;3;5;6;5;6;7;5;7; GO:0031974;GO:0031981;GO:0016020;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:1990904;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0005654;GO:0048471;GO:0005737;GO:0044446;GO:0044444;GO:0000974;GO:0005730;GO:0005634;GO:0044451;GO:0071013;GO:0044464;GO:0005623;GO:0030529;GO:0032991;GO:0032993;GO:0005575;GO:0070013;GO:0005681; membrane-enclosed lumen;nuclear lumen;membrane;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;ribonucleoprotein complex;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;nucleoplasm;perinuclear region of cytoplasm;cytoplasm;intracellular organelle part;cytoplasmic part;Prp19 complex;nucleolus;nucleus;nucleoplasm part;catalytic step 2 spliceosome;cell part;cell;intracellular ribonucleoprotein complex;macromolecular complex;protein-DNA complex;cellular_component;intracellular organelle lumen;spliceosomal complex; 2;5;2;3;4;4;3;4;3;2;3;3;3;3;3;2;7;6;5;5;4;3;4;4;5;5;5;6;2;2;4;2;3;1;4;5; GO:1901363;GO:0019904;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0071987;GO:0097159;GO:0003723;GO:0005515;GO:0044822; heterocyclic compound binding;protein domain specific binding;molecular_function;binding;nucleic acid binding;DNA binding;WD40-repeat domain binding;organic cyclic compound binding;RNA binding;protein binding;poly(A) RNA binding; 3;4;1;2;4;5;5;3;5;3;6; K12860 map03040; Spliceosome; IPR009057;IPR001005;IPR017930;IPR021786; Homeobox domain-like;SANT/Myb domain;Myb domain;Pre-mRNA splicing factor component Cdc5p/Cef1; nucleus Hs11067747 1645.0 AD [A] RNA processing and modification;[D] Cell cycle control, cell division, chromosome partitioning; Q9NWK9 Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1 - [BCD1_HUMAN] 1.011 0.985 0.953 0.993 1.16 1.336 1.026395939 nan 0.856034483 nan 0.96751269 nan 1.151724138 nan GO:0022607;GO:0070271;GO:0043933;GO:0006403;GO:0034622;GO:0071840;GO:0071822;GO:0042254;GO:0016043;GO:0065003;GO:0022618;GO:0000491;GO:0000492;GO:0009987;GO:0006461;GO:0071826;GO:0022613;GO:0008150;GO:0048254;GO:0051179;GO:0051259;GO:0033036;GO:0044085; cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;RNA localization;cellular macromolecular complex assembly;cellular component organization or biogenesis;protein complex subunit organization;ribosome biogenesis;cellular component organization;macromolecular complex assembly;ribonucleoprotein complex assembly;small nucleolar ribonucleoprotein complex assembly;box C/D snoRNP assembly;cellular process;protein complex assembly;ribonucleoprotein complex subunit organization;ribonucleoprotein complex biogenesis;biological_process;snoRNA localization;localization;protein oligomerization;macromolecule localization;cellular component biogenesis; 4;4;4;4;6;2;5;5;3;5;5;6;7;2;5;5;4;1;5;2;6;3;3; GO:1990904;GO:0005622;GO:0043227;GO:0043226;GO:0070062;GO:0070761;GO:0005576;GO:0030529;GO:0032991;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005575;GO:0044424;GO:0044421; ribonucleoprotein complex;intracellular;membrane-bounded organelle;organelle;extracellular exosome;pre-snoRNP complex;extracellular region;intracellular ribonucleoprotein complex;macromolecular complex;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;cellular_component;intracellular part;extracellular region part; 3;3;3;2;4;5;2;4;2;3;4;3;2;2;1;3;2; GO:0019899;GO:0046872;GO:0003674;GO:0005488;GO:0043169;GO:0001094;GO:0001091;GO:0001099;GO:0043167;GO:0042802;GO:0001085;GO:0051117;GO:0008134;GO:0001098;GO:0005515; enzyme binding;metal ion binding;molecular_function;binding;cation binding;TFIID-class transcription factor binding;RNA polymerase II basal transcription factor binding;basal RNA polymerase II transcription machinery binding;ion binding;identical protein binding;RNA polymerase II transcription factor binding;ATPase binding;transcription factor binding;basal transcription machinery binding;protein binding; 4;5;1;2;4;7;6;5;3;4;5;5;4;4;3; IPR007529; Zinc finger, HIT-type; cytosol Hs20149643 964.0 R [R] General function prediction only; Q9Y653 Adhesion G-protein coupled receptor G1 OS=Homo sapiens OX=9606 GN=ADGRG1 PE=1 SV=2 - [AGRG1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0051716;GO:0022030;GO:0045785;GO:0009966;GO:0009967;GO:0048699;GO:0048513;GO:0048514;GO:0010721;GO:0048518;GO:0048519;GO:0051057;GO:0051056;GO:0048468;GO:0003002;GO:0022029;GO:0044700;GO:0044707;GO:0048870;GO:0007154;GO:0060322;GO:0021871;GO:0021537;GO:0010573;GO:0035023;GO:0006928;GO:0051674;GO:0035556;GO:0050789;GO:0009653;GO:0001568;GO:0065007;GO:2001223;GO:2001222;GO:0016477;GO:0007186;GO:0048646;GO:0042063;GO:0050793;GO:0021819;GO:0050794;GO:0021543;GO:0008150;GO:0051239;GO:0048731;GO:1902533;GO:1902531;GO:0007420;GO:0050896;GO:0051961;GO:0051960;GO:2000145;GO:0048869;GO:0030155;GO:0030154;GO:0046578;GO:0046579;GO:0023056;GO:0035025;GO:0023052;GO:0060284;GO:0021885;GO:0023051;GO:0010647;GO:0010646;GO:0022008;GO:0044699;GO:0007417;GO:0050767;GO:0042127;GO:0051241;GO:0001944;GO:0050768;GO:0021799;GO:2000177;GO:0022610;GO:2000179;GO:0021795;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0009987;GO:0051271;GO:0045596;GO:0045595;GO:0040012;GO:0021987;GO:0032879;GO:0051093;GO:0001816;GO:0021796;GO:0001764;GO:0021801;GO:0008284;GO:0001525;GO:0007275;GO:0007389;GO:0070528;GO:0061351;GO:0030900;GO:0021978;GO:0030336;GO:0030334;GO:0007267;GO:2000146;GO:0044767;GO:0044763;GO:0007155;GO:0007266;GO:0007265;GO:0007264;GO:0051179;GO:0008347;GO:0040011;GO:0040013;GO:0051270;GO:0007399;GO:0048856;GO:2000026;GO:0048523;GO:0048522; positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;cellular response to stimulus;telencephalon glial cell migration;positive regulation of cell adhesion;regulation of signal transduction;positive regulation of signal transduction;generation of neurons;animal organ development;blood vessel morphogenesis;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;positive regulation of small GTPase mediated signal transduction;regulation of small GTPase mediated signal transduction;cell development;regionalization;telencephalon cell migration;single organism signaling;single-multicellular organism process;cell motility;cell communication;head development;forebrain regionalization;telencephalon development;vascular endothelial growth factor production;regulation of Rho protein signal transduction;movement of cell or subcellular component;localization of cell;intracellular signal transduction;regulation of biological process;anatomical structure morphogenesis;blood vessel development;biological regulation;negative regulation of neuron migration;regulation of neuron migration;cell migration;G-protein coupled receptor signaling pathway;anatomical structure formation involved in morphogenesis;gliogenesis;regulation of developmental process;layer formation in cerebral cortex;regulation of cellular process;pallium development;biological_process;regulation of multicellular organismal process;system development;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;brain development;response to stimulus;negative regulation of nervous system development;regulation of nervous system development;regulation of cell motility;cellular developmental process;regulation of cell adhesion;cell differentiation;regulation of Ras protein signal transduction;positive regulation of Ras protein signal transduction;positive regulation of signaling;positive regulation of Rho protein signal transduction;signaling;regulation of cell development;forebrain cell migration;regulation of signaling;positive regulation of cell communication;regulation of cell communication;neurogenesis;single-organism process;central nervous system development;regulation of neurogenesis;regulation of cell proliferation;negative regulation of multicellular organismal process;vasculature development;negative regulation of neurogenesis;cerebral cortex radially oriented cell migration;regulation of neural precursor cell proliferation;biological adhesion;positive regulation of neural precursor cell proliferation;cerebral cortex cell migration;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;negative regulation of cellular component movement;negative regulation of cell differentiation;regulation of cell differentiation;regulation of locomotion;cerebral cortex development;regulation of localization;negative regulation of developmental process;cytokine production;cerebral cortex regionalization;neuron migration;cerebral cortex radial glia guided migration;positive regulation of cell proliferation;angiogenesis;multicellular organism development;pattern specification process;protein kinase C signaling;neural precursor cell proliferation;forebrain development;telencephalon regionalization;negative regulation of cell migration;regulation of cell migration;cell-cell signaling;negative regulation of cell motility;single-organism developmental process;single-organism cellular process;cell adhesion;Rho protein signal transduction;Ras protein signal transduction;small GTPase mediated signal transduction;localization;glial cell migration;locomotion;negative regulation of locomotion;regulation of cellular component movement;nervous system development;anatomical structure development;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process; 3;3;5;5;4;5;3;6;4;4;4;7;4;4;5;2;2;6;6;4;5;5;3;3;3;4;4;5;4;5;8;4;3;5;2;3;4;2;6;6;4;5;3;7;3;4;3;4;1;3;4;5;5;4;2;4;5;4;4;4;5;7;7;3;8;2;5;5;3;4;4;6;2;5;6;4;3;5;5;6;5;2;5;5;2;4;2;3;2;4;4;4;3;4;3;3;4;5;5;7;4;4;4;4;6;4;4;5;5;5;4;4;3;3;3;8;7;6;2;5;2;3;4;5;3;4;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0097450;GO:0042995;GO:0043230;GO:0044425;GO:0044421;GO:0043227;GO:0031224;GO:0097386;GO:0031226;GO:1903561;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0097449;GO:0071944;GO:0070062;GO:0043226;GO:0097451;GO:0005887;GO:0005886;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;astrocyte end-foot;cell projection;extracellular organelle;membrane part;extracellular region part;membrane-bounded organelle;intrinsic component of membrane;glial cell projection;intrinsic component of plasma membrane;extracellular vesicle;plasma membrane part;cell part;cell;intracellular;astrocyte projection;cell periphery;extracellular exosome;organelle;glial limiting end-foot;integral component of plasma membrane;plasma membrane;cellular_component;extracellular region; 4;4;2;6;3;3;2;2;3;3;4;4;3;3;2;2;3;5;3;4;2;7;4;3;1;2; GO:0050840;GO:0060089;GO:0044877;GO:0099600;GO:0003674;GO:0005488;GO:0004930;GO:0032403;GO:0005515;GO:0005518;GO:0038023;GO:0004872;GO:0004871;GO:0004888; extracellular matrix binding;molecular transducer activity;macromolecular complex binding;transmembrane receptor activity;molecular_function;binding;G-protein coupled receptor activity;protein complex binding;protein binding;collagen binding;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity; 3;2;3;4;1;2;5;4;3;5;3;3;2;4; K08450 IPR017981;IPR000203;IPR000832;IPR003910; GPCR, family 2-like;GPS motif;GPCR, family 2, secretin-like;GPCR, family 2, orphan receptor, GPR1/GPR3/GPR5; plasma membrane Hs19923768 1418.0 T [T] Signal transduction mechanisms; Q86XL3 Ankyrin repeat and LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKLE2 PE=1 SV=4 - [ANKL2_HUMAN] 1.023 1.278 0.782 1.018 1.045 1.362 0.800469484 nan 0.974162679 nan 0.611893584 nan 1.303349282 nan GO:0019220;GO:0019222;GO:0006470;GO:0061024;GO:0000280;GO:0071840;GO:0080090;GO:0010604;GO:0010256;GO:0010921;GO:0048518;GO:0048519;GO:0060255;GO:0031468;GO:0042325;GO:0042326;GO:0019538;GO:0034047;GO:0009892;GO:0009893;GO:0007067;GO:0050789;GO:0044267;GO:0044260;GO:0016043;GO:0065007;GO:0007049;GO:0065009;GO:0050790;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0035303;GO:0035304;GO:0035307;GO:0035306;GO:0051336;GO:0043666;GO:0031401;GO:0044802;GO:0016311;GO:0016310;GO:0044699;GO:0010562;GO:0010563;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0006996;GO:0006997;GO:0009987;GO:0032268;GO:0043170;GO:0007084;GO:0031325;GO:0031324;GO:0031323;GO:1903047;GO:0022402;GO:0006998;GO:0051301;GO:1902589;GO:0071704;GO:0000278;GO:0045937;GO:0045936;GO:0006464;GO:0051174;GO:0044763;GO:0044238;GO:0044237;GO:0006796;GO:0048285;GO:0006793;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of metabolic process;protein dephosphorylation;membrane organization;nuclear division;cellular component organization or biogenesis;regulation of primary metabolic process;positive regulation of macromolecule metabolic process;endomembrane system organization;regulation of phosphatase activity;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;nuclear envelope reassembly;regulation of phosphorylation;negative regulation of phosphorylation;protein metabolic process;regulation of protein phosphatase type 2A activity;negative regulation of metabolic process;positive regulation of metabolic process;mitotic nuclear division;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;cell cycle;regulation of molecular function;regulation of catalytic activity;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of dephosphorylation;regulation of protein dephosphorylation;positive regulation of protein dephosphorylation;positive regulation of dephosphorylation;regulation of hydrolase activity;regulation of phosphoprotein phosphatase activity;positive regulation of protein modification process;single-organism membrane organization;dephosphorylation;phosphorylation;single-organism process;positive regulation of phosphorus metabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;organelle organization;nucleus organization;cellular process;regulation of cellular protein metabolic process;macromolecule metabolic process;mitotic nuclear envelope reassembly;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle process;nuclear envelope organization;cell division;single-organism organelle organization;organic substance metabolic process;mitotic cell cycle;positive regulation of phosphate metabolic process;negative regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;organelle fission;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process; 6;3;7;4;6;2;4;4;4;6;2;2;4;6;7;7;4;8;3;3;5;2;5;4;3;2;4;3;4;3;5;5;1;2;7;7;7;7;5;7;6;4;6;6;2;5;5;5;5;5;6;4;5;2;5;4;6;4;4;4;5;4;5;4;4;3;5;6;6;6;5;3;3;3;5;5;4;3;3; GO:0005783;GO:0005789;GO:0031224;GO:0016021;GO:0016020;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0030176;GO:0005622;GO:0043227;GO:0044432;GO:0012505;GO:0044446;GO:0044444;GO:0042175;GO:0031301;GO:0031300;GO:0031227;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0043226;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;intrinsic component of membrane;integral component of membrane;membrane;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;integral component of endoplasmic reticulum membrane;intracellular;membrane-bounded organelle;endoplasmic reticulum part;endomembrane system;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;integral component of organelle membrane;intrinsic component of organelle membrane;intrinsic component of endoplasmic reticulum membrane;cytoplasm;organelle membrane;cell part;cell;organelle;cellular_component; 4;3;3;4;2;4;4;3;2;2;3;4;3;3;4;3;3;4;3;4;3;4;4;3;2;2;2;1; GO:0098772;GO:0019903;GO:0019902;GO:0003674;GO:0005488;GO:0019888;GO:0019899;GO:0019208;GO:0005515;GO:0008601;GO:0030234;GO:0051721; molecular function regulator;protein phosphatase binding;phosphatase binding;molecular_function;binding;protein phosphatase regulator activity;enzyme binding;phosphatase regulator activity;protein binding;protein phosphatase type 2A regulator activity;enzyme regulator activity;protein phosphatase 2A binding; 2;6;5;1;2;5;4;4;3;6;3;7; K21412 IPR035006;IPR035007;IPR011320;IPR003887;IPR020683;IPR011015; Ankyrin repeat and LEM domain-containing protein 2, LEM domain;Ankyrin repeat and LEM domain-containing protein 2;Ribonuclease H1, N-terminal;LEM domain;Ankyrin repeat-containing domain;LEM/LEM-like domain; extracellular CE27643 182.0 R [R] General function prediction only; P01619 Immunoglobulin kappa variable 3-20 OS=Homo sapiens OX=9606 GN=IGKV3-20 PE=1 SV=2 - [KV320_HUMAN] 1.03 1.118 0.859 0.926 1.183 1.127 0.921288014 0.039795304 0.782755706 0.000937403 0.768336315 0.024102587 0.952662722 0.765597944 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0005615;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular space;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;3;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular Q969X0 RILP-like protein 2 OS=Homo sapiens OX=9606 GN=RILPL2 PE=1 SV=1 - [RIPL2_HUMAN] 0.791 1.22 0.689 0.976 1.62 0.936 0.648360656 nan 0.602469136 nan 0.564754098 nan 0.577777778 nan GO:0008104;GO:0048468;GO:0061024;GO:0007009;GO:0090002;GO:0071840;GO:0072659;GO:0070727;GO:0048869;GO:0010256;GO:0030855;GO:1903445;GO:0033036;GO:0002064;GO:0045184;GO:0072657;GO:0051668;GO:1990778;GO:0000902;GO:0006886;GO:0016043;GO:0006810;GO:0009888;GO:0044802;GO:0051234;GO:0046907;GO:0046909;GO:0008150;GO:0030154;GO:0003382;GO:0009653;GO:0044699;GO:0032502;GO:0060429;GO:0009987;GO:0032594;GO:0032989;GO:0071702;GO:0034613;GO:0044767;GO:0044765;GO:0000904;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0090150;GO:0048856;GO:0015031;GO:1902582;GO:1902580; protein localization;cell development;membrane organization;plasma membrane organization;establishment of protein localization to plasma membrane;cellular component organization or biogenesis;protein localization to plasma membrane;cellular macromolecule localization;cellular developmental process;endomembrane system organization;epithelial cell differentiation;protein transport from ciliary membrane to plasma membrane;macromolecule localization;epithelial cell development;establishment of protein localization;protein localization to membrane;localization within membrane;protein localization to cell periphery;cell morphogenesis;intracellular protein transport;cellular component organization;transport;tissue development;single-organism membrane organization;establishment of localization;intracellular transport;intermembrane transport;biological_process;cell differentiation;epithelial cell morphogenesis;anatomical structure morphogenesis;single-organism process;developmental process;epithelium development;cellular process;protein transport within lipid bilayer;cellular component morphogenesis;organic substance transport;cellular protein localization;single-organism developmental process;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;establishment of protein localization to membrane;anatomical structure development;protein transport;single-organism intracellular transport;single-organism cellular localization; 4;4;4;5;6;2;6;4;4;4;6;6;3;5;4;5;4;6;5;6;3;4;4;4;3;5;5;1;5;6;3;2;2;5;2;5;4;5;5;3;4;5;3;4;2;3;3;5;3;5;5;4; GO:0005815;GO:0031982;GO:0016020;GO:0042995;GO:0043230;GO:0043232;GO:0005829;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0072372;GO:0070062;GO:0005813;GO:0015630;GO:1903561;GO:0005575;GO:0005576; microtubule organizing center;vesicle;membrane;cell projection;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;primary cilium;extracellular exosome;centrosome;microtubule cytoskeleton;extracellular vesicle;cellular_component;extracellular region; 5;4;2;3;3;4;5;3;2;2;3;3;3;3;2;5;4;3;4;4;2;2;3;4;4;5;6;3;1;2; GO:0003674;GO:0005488;GO:0042802;GO:0005515; molecular_function;binding;identical protein binding;protein binding; 1;2;4;3; IPR034744;IPR034743;IPR021563; RH2 domain;RH1 domain;Rab interacting lysosomal protein, dimerization domain; nucleus P01615 Immunoglobulin kappa variable 2D-28 OS=Homo sapiens OX=9606 GN=IGKV2D-28 PE=1 SV=2 - [KVD28_HUMAN] 1.324 0.363 1.679 1.274 0.7 nan 3.64738292 nan 1.82 nan 4.625344353 nan nan nan GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q9NQ89 Protein C12orf4 OS=Homo sapiens OX=9606 GN=C12orf4 PE=2 SV=1 - [CL004_HUMAN] 1.118 1.373 0.845 0.832 1.031 0.994 0.81427531 nan 0.806983511 nan 0.615440641 nan 0.964112512 nan GO:0006887;GO:0051234;GO:0060341;GO:0050794;GO:0050865;GO:0051049;GO:0032386;GO:0051649;GO:0048583;GO:0045321;GO:0032940;GO:0002703;GO:1903530;GO:0051640;GO:0051656;GO:0050789;GO:0044699;GO:0002376;GO:0002443;GO:0051046;GO:0033003;GO:0043300;GO:0043303;GO:0043304;GO:0045055;GO:0046907;GO:0002684;GO:0002366;GO:0002682;GO:0002886;GO:0048518;GO:0065007;GO:1903305;GO:0044763;GO:0017157;GO:0006810;GO:0032418;GO:0009987;GO:0060627;GO:0002448;GO:0001775;GO:0008150;GO:0006955;GO:0032879;GO:0002444;GO:0051179;GO:1902578;GO:0051641;GO:0002263;GO:0046903;GO:0050776;GO:0016192;GO:0002279;GO:0050896;GO:0002274;GO:0044765;GO:0002694;GO:0002697;GO:0043299;GO:0033006;GO:0002252;GO:1902582;GO:1902580;GO:0002699;GO:0002275;GO:0045576; exocytosis;establishment of localization;regulation of cellular localization;regulation of cellular process;regulation of cell activation;regulation of transport;regulation of intracellular transport;establishment of localization in cell;regulation of response to stimulus;leukocyte activation;secretion by cell;regulation of leukocyte mediated immunity;regulation of secretion by cell;organelle localization;establishment of organelle localization;regulation of biological process;single-organism process;immune system process;leukocyte mediated immunity;regulation of secretion;regulation of mast cell activation;regulation of leukocyte degranulation;mast cell degranulation;regulation of mast cell degranulation;regulated exocytosis;intracellular transport;positive regulation of immune system process;leukocyte activation involved in immune response;regulation of immune system process;regulation of myeloid leukocyte mediated immunity;positive regulation of biological process;biological regulation;regulation of regulated secretory pathway;single-organism cellular process;regulation of exocytosis;transport;lysosome localization;cellular process;regulation of vesicle-mediated transport;mast cell mediated immunity;cell activation;biological_process;immune response;regulation of localization;myeloid leukocyte mediated immunity;localization;single-organism localization;cellular localization;cell activation involved in immune response;secretion;regulation of immune response;vesicle-mediated transport;mast cell activation involved in immune response;response to stimulus;myeloid leukocyte activation;single-organism transport;regulation of leukocyte activation;regulation of immune effector process;leukocyte degranulation;regulation of mast cell activation involved in immune response;immune effector process;single-organism intracellular transport;single-organism cellular localization;positive regulation of immune effector process;myeloid cell activation involved in immune response;mast cell activation; 5;3;4;3;4;4;5;4;3;3;4;5;5;4;4;2;2;2;4;5;5;5;5;6;6;5;3;4;3;6;2;2;6;3;5;4;5;2;4;6;4;1;3;3;5;2;3;3;4;5;4;5;4;2;4;4;4;4;4;5;3;5;4;4;5;5; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; IPR019311; Protein of unknown function DUF2362; nucleus Hs9966847 1149.0 S [S] Function unknown; Q14183 Double C2-like domain-containing protein alpha OS=Homo sapiens OX=9606 GN=DOC2A PE=1 SV=5 - [DOC2A_HUMAN] 0.995 1.2 0.966 0.941 1.012 1.281 0.829166667 nan 0.929841897 nan 0.805 nan 1.265810277 nan GO:0051046;GO:0099643;GO:0051049;GO:0001505;GO:0051656;GO:0051650;GO:0097479;GO:0099504;GO:0006836;GO:0097480;GO:0044700;GO:0065008;GO:0016192;GO:0044707;GO:0098916;GO:0032940;GO:0048489;GO:0006887;GO:0045055;GO:0065007;GO:1903305;GO:0006810;GO:0050794;GO:0008150;GO:0051234;GO:0046903;GO:0046907;GO:0016079;GO:0099531;GO:0099536;GO:0051648;GO:0051649;GO:0023052;GO:1903530;GO:0044699;GO:0017158;GO:0051640;GO:0017156;GO:0017157;GO:0032502;GO:0032501;GO:0009987;GO:0060627;GO:0032879;GO:0016482;GO:0048731;GO:0060341;GO:0007275;GO:0050789;GO:0023061;GO:0044767;GO:0044765;GO:0044763;GO:0007269;GO:0007268;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:1902580;GO:0007399;GO:0048856;GO:1902582;GO:0099537; regulation of secretion;signal release from synapse;regulation of transport;regulation of neurotransmitter levels;establishment of organelle localization;establishment of vesicle localization;synaptic vesicle localization;synaptic vesicle cycle;neurotransmitter transport;establishment of synaptic vesicle localization;single organism signaling;regulation of biological quality;vesicle-mediated transport;single-multicellular organism process;anterograde trans-synaptic signaling;secretion by cell;synaptic vesicle transport;exocytosis;regulated exocytosis;biological regulation;regulation of regulated secretory pathway;transport;regulation of cellular process;biological_process;establishment of localization;secretion;intracellular transport;synaptic vesicle exocytosis;presynaptic process involved in synaptic transmission;synaptic signaling;vesicle localization;establishment of localization in cell;signaling;regulation of secretion by cell;single-organism process;regulation of calcium ion-dependent exocytosis;organelle localization;calcium ion regulated exocytosis;regulation of exocytosis;developmental process;multicellular organismal process;cellular process;regulation of vesicle-mediated transport;regulation of localization;cytosolic transport;system development;regulation of cellular localization;multicellular organism development;regulation of biological process;signal release;single-organism developmental process;single-organism transport;single-organism cellular process;neurotransmitter secretion;synaptic transmission;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;single-organism cellular localization;nervous system development;anatomical structure development;single-organism intracellular transport;trans-synaptic signaling; 5;6;4;4;4;5;6;5;5;6;3;3;5;3;7;4;5;5;6;2;6;4;3;1;3;5;5;3;2;5;5;4;2;5;2;7;4;7;5;2;2;2;4;3;6;4;4;4;2;5;3;4;3;3;8;4;4;2;3;3;4;5;3;5;6; GO:0030054;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0099501;GO:0099503;GO:0098588;GO:0042995;GO:0043231;GO:0044424;GO:0044422;GO:0043227;GO:0043226;GO:0044433;GO:0012505;GO:0012506;GO:0030672;GO:0044446;GO:0005773;GO:0044444;GO:0097708;GO:0008021;GO:0000323;GO:0005737;GO:0031090;GO:0031410;GO:0044456;GO:0043005;GO:0030658;GO:0030659;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0045202;GO:0030133;GO:0005764;GO:0098805;GO:0070382;GO:0097458;GO:0005575;GO:0098793; cell junction;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;exocytic vesicle membrane;secretory vesicle;bounding membrane of organelle;cell projection;intracellular membrane-bounded organelle;intracellular part;organelle part;membrane-bounded organelle;organelle;cytoplasmic vesicle part;endomembrane system;vesicle membrane;synaptic vesicle membrane;intracellular organelle part;vacuole;cytoplasmic part;intracellular vesicle;synaptic vesicle;lytic vacuole;cytoplasm;organelle membrane;cytoplasmic vesicle;synapse part;neuron projection;transport vesicle membrane;cytoplasmic vesicle membrane;cell part;intracellular organelle;cell;intracellular;synapse;transport vesicle;lysosome;whole membrane;exocytic vesicle;neuron part;cellular_component;presynapse; 2;4;5;2;5;5;6;4;3;4;3;2;3;2;4;3;4;3;3;5;4;4;3;6;4;3;5;2;4;4;5;2;3;2;3;2;4;7;3;5;3;1;3; GO:0030276;GO:0005544;GO:0046872;GO:0019905;GO:0003674;GO:0005488;GO:0000149;GO:0043168;GO:0005543;GO:0043169;GO:0043167;GO:0008289;GO:0005515;GO:0005509; clathrin binding;calcium-dependent phospholipid binding;metal ion binding;syntaxin binding;molecular_function;binding;SNARE binding;anion binding;phospholipid binding;cation binding;ion binding;lipid binding;protein binding;calcium ion binding; 4;5;5;5;1;2;4;4;4;4;3;3;3;6; K19916 IPR014638;IPR030535;IPR000008;IPR001565; Double C2 protein, alpha/beta/gamma;Double C2-like domain-containing protein alpha;C2 domain;Synaptotagmin; cytosol Hs4503353 811.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q99698 Lysosomal-trafficking regulator OS=Homo sapiens OX=9606 GN=LYST PE=1 SV=3 - [LYST_HUMAN] 1.088 1.106 0.868 1.058 1.153 0.842 0.983725136 nan 0.917606245 nan 0.784810127 nan 0.730268864 nan GO:0008104;GO:0032438;GO:0060326;GO:0071840;GO:0051716;GO:0042330;GO:0009615;GO:0009617;GO:0010256;GO:0001909;GO:0001906;GO:0033036;GO:0030595;GO:0006935;GO:0043473;GO:0045184;GO:0051707;GO:0051704;GO:0016197;GO:0009607;GO:0009605;GO:0048870;GO:0016050;GO:0002376;GO:0007041;GO:0006928;GO:0051674;GO:0042742;GO:0016043;GO:0016477;GO:0006810;GO:0006952;GO:0006950;GO:0008150;GO:0006955;GO:0051234;GO:0051607;GO:0046907;GO:0050896;GO:0042267;GO:0043207;GO:0008333;GO:0070887;GO:0007040;GO:0044699;GO:0002228;GO:0006996;GO:0032509;GO:0098542;GO:0007033;GO:0007034;GO:0033364;GO:0009987;GO:0033363;GO:0032510;GO:0048753;GO:0050900;GO:0033059;GO:0071702;GO:0001562;GO:0045087;GO:0002449;GO:0044765;GO:0044763;GO:0051649;GO:0042221;GO:0002443;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0042832;GO:0080171;GO:0002252;GO:0015031;GO:1902582; protein localization;melanosome organization;cell chemotaxis;cellular component organization or biogenesis;cellular response to stimulus;taxis;response to virus;response to bacterium;endomembrane system organization;leukocyte mediated cytotoxicity;cell killing;macromolecule localization;leukocyte chemotaxis;chemotaxis;pigmentation;establishment of protein localization;response to other organism;multi-organism process;endosomal transport;response to biotic stimulus;response to external stimulus;cell motility;vesicle organization;immune system process;lysosomal transport;movement of cell or subcellular component;localization of cell;defense response to bacterium;cellular component organization;cell migration;transport;defense response;response to stress;biological_process;immune response;establishment of localization;defense response to virus;intracellular transport;response to stimulus;natural killer cell mediated cytotoxicity;response to external biotic stimulus;endosome to lysosome transport;cellular response to chemical stimulus;lysosome organization;single-organism process;natural killer cell mediated immunity;organelle organization;endosome transport via multivesicular body sorting pathway;defense response to other organism;vacuole organization;vacuolar transport;mast cell secretory granule organization;cellular process;secretory granule organization;endosome to lysosome transport via multivesicular body sorting pathway;pigment granule organization;leukocyte migration;cellular pigmentation;organic substance transport;response to protozoan;innate immune response;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;establishment of localization in cell;response to chemical;leukocyte mediated immunity;localization;single-organism localization;cellular localization;locomotion;defense response to protozoan;lytic vacuole organization;immune effector process;protein transport;single-organism intracellular transport; 4;6;5;2;3;3;4;4;4;3;2;3;4;4;3;4;3;2;7;3;3;3;5;2;7;4;3;5;3;4;4;4;3;1;3;3;4;5;2;3;4;8;4;7;2;5;4;8;4;5;6;6;2;5;9;5;3;4;5;4;4;5;4;3;4;3;4;2;3;3;2;5;6;3;5;5; GO:0043232;GO:0044424;GO:0043229;GO:0043226;GO:0005856;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0015630;GO:0005575; intracellular non-membrane-bounded organelle;intracellular part;intracellular organelle;organelle;cytoskeleton;cytoplasm;cell part;cell;intracellular;non-membrane-bounded organelle;microtubule cytoskeleton;cellular_component; 4;3;3;2;5;4;2;2;3;3;6;1; K22937 IPR016024;IPR017986;IPR001680;IPR030464;IPR015943;IPR019775;IPR011993;IPR023362;IPR000409; Armadillo-type fold;WD40-repeat-containing domain;WD40 repeat;Lysosomal-trafficking regulator;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;PH domain-like;PH-BEACH domain;BEACH domain; plasma membrane Hs4502839 7892.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q8TCU5 Glutamate receptor ionotropic, NMDA 3A OS=Homo sapiens OX=9606 GN=GRIN3A PE=1 SV=2 - [NMD3A_HUMAN] 0.762 0.475 2.534 0.584 0.429 1.026 1.604210526 nan 1.361305361 nan 5.334736842 nan 2.391608392 nan GO:0048585;GO:0048468;GO:0016358;GO:0007165;GO:0007166;GO:0071840;GO:0051716;GO:0048869;GO:0007215;GO:0048519;GO:0048583;GO:0070838;GO:0010033;GO:0003008;GO:0044700;GO:0044707;GO:0031175;GO:0050789;GO:0016043;GO:0001964;GO:0065007;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:0050794;GO:0008150;GO:0051234;GO:0050896;GO:0097305;GO:0032102;GO:0032101;GO:0030154;GO:0023052;GO:0042221;GO:0044699;GO:0032502;GO:0032501;GO:0035235;GO:0009987;GO:0030001;GO:0072511;GO:0048731;GO:0030030;GO:0050905;GO:0060134;GO:0007275;GO:0050877;GO:0009605;GO:0048666;GO:0030182;GO:0044767;GO:0045471;GO:0044765;GO:0044763;GO:0007154;GO:0022008;GO:0051179;GO:1902578;GO:1901700;GO:0048699;GO:0007399;GO:0048856; negative regulation of response to stimulus;cell development;dendrite development;signal transduction;cell surface receptor signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;glutamate receptor signaling pathway;negative regulation of biological process;regulation of response to stimulus;divalent metal ion transport;response to organic substance;system process;single organism signaling;single-multicellular organism process;neuron projection development;regulation of biological process;cellular component organization;startle response;biological regulation;cation transport;ion transport;transport;calcium ion transport;regulation of cellular process;biological_process;establishment of localization;response to stimulus;response to alcohol;negative regulation of response to external stimulus;regulation of response to external stimulus;cell differentiation;signaling;response to chemical;single-organism process;developmental process;multicellular organismal process;ionotropic glutamate receptor signaling pathway;cellular process;metal ion transport;divalent inorganic cation transport;system development;cell projection organization;neuromuscular process;prepulse inhibition;multicellular organism development;neurological system process;response to external stimulus;neuron development;neuron differentiation;single-organism developmental process;response to ethanol;single-organism transport;single-organism cellular process;cell communication;neurogenesis;localization;single-organism localization;response to oxygen-containing compound;generation of neurons;nervous system development;anatomical structure development; 3;4;4;4;5;2;3;4;6;2;3;8;4;3;3;3;5;2;3;4;2;6;5;4;9;3;1;3;2;5;4;4;5;2;3;2;2;2;7;2;7;7;4;4;5;5;4;4;3;5;6;3;6;4;3;4;6;2;3;4;7;5;3; GO:0098802;GO:0097060;GO:0016021;GO:0016020;GO:1902495;GO:0043235;GO:0098589;GO:0044297;GO:0036477;GO:0042995;GO:0043234;GO:0043232;GO:0030054;GO:0044424;GO:0044425;GO:0098590;GO:0043229;GO:0043228;GO:0031224;GO:0043025;GO:1990351;GO:0060076;GO:0031226;GO:0044456;GO:0043005;GO:0044459;GO:0017146;GO:0008328;GO:0045211;GO:0044464;GO:0005623;GO:0005622;GO:0034702;GO:0045202;GO:0099572;GO:0071944;GO:0098797;GO:0098805;GO:0043226;GO:0097458;GO:0005887;GO:0005886;GO:0032991;GO:0005575;GO:0098796;GO:0098794;GO:0014069; plasma membrane receptor complex;synaptic membrane;integral component of membrane;membrane;transmembrane transporter complex;receptor complex;membrane region;cell body;somatodendritic compartment;cell projection;protein complex;intracellular non-membrane-bounded organelle;cell junction;intracellular part;membrane part;plasma membrane region;intracellular organelle;non-membrane-bounded organelle;intrinsic component of membrane;neuronal cell body;transporter complex;excitatory synapse;intrinsic component of plasma membrane;synapse part;neuron projection;plasma membrane part;NMDA selective glutamate receptor complex;ionotropic glutamate receptor complex;postsynaptic membrane;cell part;cell;intracellular;ion channel complex;synapse;postsynaptic specialization;cell periphery;plasma membrane protein complex;whole membrane;organelle;neuron part;integral component of plasma membrane;plasma membrane;macromolecular complex;cellular_component;membrane protein complex;postsynapse;postsynaptic density; 4;3;4;2;4;4;3;3;4;3;3;4;2;3;2;4;3;3;3;4;4;3;4;2;4;3;6;5;4;2;2;3;5;2;3;3;4;3;2;3;4;3;2;1;3;3;4; GO:0005261;GO:0005262;GO:0060089;GO:0008066;GO:0016597;GO:0016594;GO:0015085;GO:0046873;GO:0030594;GO:0019903;GO:0019902;GO:0099600;GO:0003674;GO:0005488;GO:0022803;GO:0005230;GO:0005231;GO:0005515;GO:0005234;GO:0022891;GO:0022890;GO:0022892;GO:0031406;GO:0015075;GO:0015267;GO:0019899;GO:0043167;GO:0043168;GO:0043169;GO:0015276;GO:0072509;GO:0022824;GO:0042802;GO:0051721;GO:0005215;GO:0005216;GO:0043177;GO:0022836;GO:0022835;GO:0022834;GO:0022838;GO:0038023;GO:0036094;GO:0004872;GO:0004871;GO:0004972;GO:0004970;GO:0022857;GO:0008324;GO:0004888; cation channel activity;calcium channel activity;molecular transducer activity;glutamate receptor activity;amino acid binding;glycine binding;calcium ion transmembrane transporter activity;metal ion transmembrane transporter activity;neurotransmitter receptor activity;protein phosphatase binding;phosphatase binding;transmembrane receptor activity;molecular_function;binding;passive transmembrane transporter activity;extracellular ligand-gated ion channel activity;excitatory extracellular ligand-gated ion channel activity;protein binding;extracellular-glutamate-gated ion channel activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;carboxylic acid binding;ion transmembrane transporter activity;channel activity;enzyme binding;ion binding;anion binding;cation binding;ligand-gated ion channel activity;divalent inorganic cation transmembrane transporter activity;transmitter-gated ion channel activity;identical protein binding;protein phosphatase 2A binding;transporter activity;ion channel activity;organic acid binding;gated channel activity;transmitter-gated channel activity;ligand-gated channel activity;substrate-specific channel activity;signaling receptor activity;small molecule binding;receptor activity;signal transducer activity;NMDA glutamate receptor activity;ionotropic glutamate receptor activity;transmembrane transporter activity;cation transmembrane transporter activity;transmembrane signaling receptor activity; 7;8;2;5;6;5;9;8;4;6;5;4;1;2;4;7;8;3;9;4;7;3;5;5;5;4;3;4;4;6;8;6;4;7;2;6;4;6;5;5;5;3;3;3;2;7;6;3;6;4; K05213 map04024;map04080;map04724;map05030;map05031;map05033;map05034; cAMP signaling pathway;Neuroactive ligand-receptor interaction;Glutamatergic synapse;Cocaine addiction;Amphetamine addiction;Nicotine addiction;Alcoholism; IPR001320;IPR028082;IPR001508;IPR019594; Ionotropic glutamate receptor;Periplasmic binding protein-like I;Ionotropic glutamate receptor, metazoa;Ionotropic glutamate receptor, L-glutamate and glycine-binding domain; plasma membrane Hs20143964 2313.0 PET [P] Inorganic ion transport and metabolism;[E] Amino acid transport and metabolism;[T] Signal transduction mechanisms; O75128 Protein cordon-bleu OS=Homo sapiens OX=9606 GN=COBL PE=1 SV=2 - [COBL_HUMAN] 1.069 1.027 1.024 1.097 1.019 0.878 1.040895813 nan 1.076545633 nan 0.99707887 nan 0.861629048 nan GO:0035148;GO:0048589;GO:0048588;GO:0048468;GO:0016358;GO:0060491;GO:0031344;GO:0071840;GO:0031346;GO:0065003;GO:0001756;GO:0048869;GO:0045664;GO:0045666;GO:0010720;GO:0048518;GO:0061053;GO:0010975;GO:0030041;GO:0001757;GO:0001843;GO:0014020;GO:0097178;GO:0044707;GO:0007379;GO:0048598;GO:0022607;GO:0048565;GO:0061008;GO:0048568;GO:0000578;GO:0031175;GO:0050789;GO:0000904;GO:0016049;GO:0030029;GO:0016043;GO:0065007;GO:0001841;GO:0048646;GO:0051130;GO:0061564;GO:0009880;GO:0050793;GO:0050794;GO:0008154;GO:0008150;GO:0051239;GO:0060606;GO:0009952;GO:0051962;GO:0051960;GO:0070271;GO:0030154;GO:0051128;GO:0055123;GO:0009790;GO:0009792;GO:0009798;GO:0009653;GO:0035295;GO:0044699;GO:0050767;GO:1900029;GO:1900027;GO:0051240;GO:0060284;GO:0050769;GO:0030030;GO:0048513;GO:0060562;GO:0043009;GO:0060560;GO:0032502;GO:0031529;GO:0032501;GO:0035239;GO:0009987;GO:0045597;GO:0045595;GO:0001838;GO:0007409;GO:0048858;GO:0051258;GO:0050773;GO:0051094;GO:0072175;GO:0048731;GO:0048732;GO:0016331;GO:0043933;GO:0030031;GO:0034622;GO:0030036;GO:0051639;GO:0001889;GO:0009888;GO:0035282;GO:0007275;GO:0003002;GO:0007389;GO:0040007;GO:0071822;GO:0033504;GO:0032989;GO:0048812;GO:0048729;GO:0048666;GO:0048667;GO:0060429;GO:0021915;GO:0030182;GO:0002009;GO:0006461;GO:0048668;GO:0048669;GO:0044767;GO:0032990;GO:0044763;GO:0022008;GO:0043623;GO:0000902;GO:0006996;GO:0007015;GO:0048699;GO:0007010;GO:1900006;GO:0007399;GO:0048856;GO:0010976;GO:0044087;GO:1902589;GO:0044085;GO:2000026;GO:0030903;GO:0044089;GO:0048522; tube formation;developmental growth;developmental cell growth;cell development;dendrite development;regulation of cell projection assembly;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;macromolecular complex assembly;somitogenesis;cellular developmental process;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of cell development;positive regulation of biological process;somite development;regulation of neuron projection development;actin filament polymerization;somite specification;neural tube closure;primary neural tube formation;ruffle assembly;single-multicellular organism process;segment specification;embryonic morphogenesis;cellular component assembly;digestive tract development;hepaticobiliary system development;embryonic organ development;embryonic axis specification;neuron projection development;regulation of biological process;cell morphogenesis involved in differentiation;cell growth;actin filament-based process;cellular component organization;biological regulation;neural tube formation;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;axon development;embryonic pattern specification;regulation of developmental process;regulation of cellular process;actin polymerization or depolymerization;biological_process;regulation of multicellular organismal process;tube closure;anterior/posterior pattern specification;positive regulation of nervous system development;regulation of nervous system development;protein complex biogenesis;cell differentiation;regulation of cellular component organization;digestive system development;embryo development;embryo development ending in birth or egg hatching;axis specification;anatomical structure morphogenesis;tube development;single-organism process;regulation of neurogenesis;positive regulation of ruffle assembly;regulation of ruffle assembly;positive regulation of multicellular organismal process;regulation of cell development;positive regulation of neurogenesis;cell projection organization;animal organ development;epithelial tube morphogenesis;chordate embryonic development;developmental growth involved in morphogenesis;developmental process;ruffle organization;multicellular organismal process;tube morphogenesis;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;embryonic epithelial tube formation;axonogenesis;cell projection morphogenesis;protein polymerization;regulation of dendrite development;positive regulation of developmental process;epithelial tube formation;system development;gland development;morphogenesis of embryonic epithelium;macromolecular complex subunit organization;cell projection assembly;cellular macromolecular complex assembly;actin cytoskeleton organization;actin filament network formation;liver development;tissue development;segmentation;multicellular organism development;regionalization;pattern specification process;growth;protein complex subunit organization;floor plate development;cellular component morphogenesis;neuron projection morphogenesis;tissue morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;epithelium development;neural tube development;neuron differentiation;morphogenesis of an epithelium;protein complex assembly;collateral sprouting;collateral sprouting in absence of injury;single-organism developmental process;cell part morphogenesis;single-organism cellular process;neurogenesis;cellular protein complex assembly;cell morphogenesis;organelle organization;actin filament organization;generation of neurons;cytoskeleton organization;positive regulation of dendrite development;nervous system development;anatomical structure development;positive regulation of neuron projection development;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;regulation of multicellular organismal development;notochord development;positive regulation of cellular component biogenesis;positive regulation of cellular process; 4;3;4;4;4;4;5;2;5;5;4;4;7;6;5;2;6;6;8;5;6;6;6;3;5;4;4;4;5;4;6;5;2;5;3;4;3;2;5;3;4;6;5;3;3;7;1;3;5;6;4;5;4;5;4;5;5;6;5;3;4;2;6;4;5;3;5;5;4;4;5;7;4;2;5;2;4;2;4;4;6;7;5;7;5;3;5;4;4;5;4;5;6;5;7;5;4;6;4;5;4;2;5;4;4;6;4;5;6;5;4;6;5;5;5;6;3;5;3;6;6;5;4;6;7;5;5;5;3;6;3;4;3;4;5;3;3; GO:0099512;GO:0099513;GO:0030425;GO:0030424;GO:0016020;GO:0030427;GO:0044297;GO:0044295;GO:0030426;GO:0036477;GO:0042995;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0043228;GO:0005856;GO:0044430;GO:0048471;GO:0043025;GO:0099568;GO:0031252;GO:0005938;GO:0044446;GO:0044444;GO:0033267;GO:0005884;GO:0005737;GO:0043005;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0071944;GO:0001726;GO:0097458;GO:0044292;GO:0005886;GO:0044294;GO:0005575;GO:0043226; supramolecular fiber;polymeric cytoskeletal fiber;dendrite;axon;membrane;site of polarized growth;cell body;axonal growth cone;growth cone;somatodendritic compartment;cell projection;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;cytoskeletal part;perinuclear region of cytoplasm;neuronal cell body;cytoplasmic region;cell leading edge;cell cortex;intracellular organelle part;cytoplasmic part;axon part;actin filament;cytoplasm;neuron projection;cell projection part;cell part;cell;intracellular;actin cytoskeleton;cell periphery;ruffle;neuron part;dendrite terminus;plasma membrane;dendritic growth cone;cellular_component;organelle; 2;3;5;5;2;3;3;5;4;4;3;3;2;4;3;3;5;4;5;4;5;3;4;3;4;4;4;4;4;3;2;2;3;6;3;4;3;4;3;5;1;2; GO:0003674;GO:0005488;GO:0003779;GO:0008092;GO:0005515;GO:0003785; molecular_function;binding;actin binding;cytoskeletal protein binding;protein binding;actin monomer binding; 1;2;5;4;3;6; K18623 IPR003124;IPR019025; WH2 domain;Cordon-bleu, ubiquitin-like domain; nucleus Q13797 Integrin alpha-9 OS=Homo sapiens OX=9606 GN=ITGA9 PE=1 SV=2 - [ITA9_HUMAN] 1.051 1.173 0.854 1.145 1.059 0.902 0.89599318 nan 1.081208687 nan 0.728047741 nan 0.851746931 nan GO:0048468;GO:0007165;GO:0007166;GO:0060326;GO:0071840;GO:0051716;GO:0042330;GO:0048869;GO:0009611;GO:0030595;GO:0030593;GO:0006935;GO:0044700;GO:0097485;GO:0009605;GO:0044707;GO:0048870;GO:0002376;GO:0030198;GO:0006928;GO:0051674;GO:0031175;GO:0050789;GO:0000904;GO:0000902;GO:0016043;GO:0065007;GO:0016477;GO:0061564;GO:0042060;GO:0050794;GO:0006950;GO:0008150;GO:0050896;GO:0048812;GO:0030154;GO:0023052;GO:0070887;GO:0007154;GO:0007411;GO:0009653;GO:0044699;GO:0097530;GO:0022610;GO:0032502;GO:0032501;GO:0009987;GO:0007409;GO:0048858;GO:0048731;GO:0097529;GO:0007229;GO:0030030;GO:1990266;GO:0050900;GO:0007275;GO:0032989;GO:0043062;GO:0071621;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044763;GO:0007155;GO:0042221;GO:0022008;GO:0051179;GO:0040011;GO:0048699;GO:0032990;GO:0007399;GO:0048856; cell development;signal transduction;cell surface receptor signaling pathway;cell chemotaxis;cellular component organization or biogenesis;cellular response to stimulus;taxis;cellular developmental process;response to wounding;leukocyte chemotaxis;neutrophil chemotaxis;chemotaxis;single organism signaling;neuron projection guidance;response to external stimulus;single-multicellular organism process;cell motility;immune system process;extracellular matrix organization;movement of cell or subcellular component;localization of cell;neuron projection development;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;biological regulation;cell migration;axon development;wound healing;regulation of cellular process;response to stress;biological_process;response to stimulus;neuron projection morphogenesis;cell differentiation;signaling;cellular response to chemical stimulus;cell communication;axon guidance;anatomical structure morphogenesis;single-organism process;granulocyte migration;biological adhesion;developmental process;multicellular organismal process;cellular process;axonogenesis;cell projection morphogenesis;system development;myeloid leukocyte migration;integrin-mediated signaling pathway;cell projection organization;neutrophil migration;leukocyte migration;multicellular organism development;cellular component morphogenesis;extracellular structure organization;granulocyte chemotaxis;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism cellular process;cell adhesion;response to chemical;neurogenesis;localization;locomotion;generation of neurons;cell part morphogenesis;nervous system development;anatomical structure development; 4;4;5;5;2;3;3;4;4;4;6;4;3;5;3;3;3;2;5;4;3;5;2;5;5;3;2;4;6;5;3;3;1;2;6;5;2;4;4;6;3;2;5;2;2;2;2;7;5;4;4;6;4;6;3;4;4;4;5;5;6;6;3;3;3;3;6;2;2;7;5;5;3; GO:0016021;GO:0016020;GO:0098589;GO:0034679;GO:0043234;GO:0043235;GO:0044425;GO:0098590;GO:0031224;GO:0008305;GO:0098636;GO:0031226;GO:0045178;GO:0009925;GO:0044459;GO:0016323;GO:0044464;GO:0005623;GO:0071944;GO:0098797;GO:0098805;GO:0098802;GO:0005887;GO:0005886;GO:0032991;GO:0005575;GO:0098796; integral component of membrane;membrane;membrane region;integrin alpha9-beta1 complex;protein complex;receptor complex;membrane part;plasma membrane region;intrinsic component of membrane;integrin complex;protein complex involved in cell adhesion;intrinsic component of plasma membrane;basal part of cell;basal plasma membrane;plasma membrane part;basolateral plasma membrane;cell part;cell;cell periphery;plasma membrane protein complex;whole membrane;plasma membrane receptor complex;integral component of plasma membrane;plasma membrane;macromolecular complex;cellular_component;membrane protein complex; 4;2;3;6;3;4;2;4;3;5;4;4;3;4;3;4;2;2;3;4;3;4;4;3;2;1;3; GO:0046872;GO:0003674;GO:0005488;GO:0043169;GO:0043167; metal ion binding;molecular_function;binding;cation binding;ion binding; 5;1;2;4;3; K06585 map04151;map04510;map04512;map04514;map04810;map05410;map05412;map05414; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy; IPR013519;IPR013517;IPR013649;IPR018184;IPR000413;IPR032695; Integrin alpha beta-propellor;FG-GAP repeat;Integrin alpha-2;Integrin alpha chain, C-terminal cytoplasmic region, conserved site;Integrin alpha chain;Integrin domain; plasma membrane Hs11321595 2155.0 W [W] Extracellular structures; Q9C073 Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1 - [F117A_HUMAN] 0.986 1.097 0.858 1.092 0.945 1.168 0.89881495 0.711913257 1.155555556 0.455602946 0.78213309 0.627062965 1.235978836 0.611269111 IPR026642; Glucocorticoid-induced transcript 1/FAM117; nucleus Q6ZMT4 Lysine-specific demethylase 7A OS=Homo sapiens OX=9606 GN=KDM7A PE=1 SV=2 - [KDM7A_HUMAN] 1.174 1.05 0.76 1.217 0.969 1.358 1.118095238 nan 1.255933953 nan 0.723809524 nan 1.401444788 nan GO:0080090;GO:0019222;GO:0060322;GO:1901362;GO:0044707;GO:1901360;GO:0044710;GO:0010604;GO:0048513;GO:0048518;GO:0016570;GO:0060255;GO:2001141;GO:0046483;GO:0070988;GO:0019538;GO:0035574;GO:0019438;GO:0016569;GO:0009893;GO:0009891;GO:0070544;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0016577;GO:0065007;GO:0071840;GO:0007417;GO:0018130;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0007420;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0033169;GO:1903508;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0070076;GO:0051252;GO:0051254;GO:1902680;GO:0048731;GO:0032502;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0008214;GO:0007275;GO:0010628;GO:0006482;GO:0006325;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0071557;GO:0010468;GO:0045935;GO:0044267;GO:0019219;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0016568;GO:0006996;GO:0044238;GO:0051276;GO:0007399;GO:0048856;GO:0044237;GO:1902589;GO:0030901;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;head development;organic cyclic compound biosynthetic process;single-multicellular organism process;organic cyclic compound metabolic process;single-organism metabolic process;positive regulation of macromolecule metabolic process;animal organ development;positive regulation of biological process;histone modification;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;demethylation;protein metabolic process;histone H4-K20 demethylation;aromatic compound biosynthetic process;covalent chromatin modification;positive regulation of metabolic process;positive regulation of biosynthetic process;histone H3-K36 demethylation;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;histone demethylation;biological regulation;cellular component organization or biogenesis;central nervous system development;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;brain development;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;histone H3-K9 demethylation;positive regulation of nucleic acid-templated transcription;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;histone lysine demethylation;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;system development;developmental process;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;protein dealkylation;multicellular organism development;positive regulation of gene expression;protein demethylation;chromatin organization;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;histone H3-K27 demethylation;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;chromatin modification;organelle organization;primary metabolic process;chromosome organization;nervous system development;anatomical structure development;cellular metabolic process;single-organism organelle organization;midbrain development;positive regulation of cellular process; 4;3;4;5;3;4;3;4;4;2;4;4;6;4;4;4;7;5;7;3;4;7;3;4;7;4;4;3;5;2;2;5;5;4;3;5;5;1;2;5;5;5;4;6;5;5;6;6;4;4;5;2;4;7;7;2;2;4;7;6;6;5;5;6;4;2;5;4;5;4;4;5;7;4;5;4;5;6;2;3;5;7;5;5;5;5;6;3;3;5;3;4;4;6;4;3;5;5;3;3;4;4;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleolus;nucleus;cell part;cell;intracellular;non-membrane-bounded organelle;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;4;3;3;2;5;3;5;5;2;2;3;3;1;4; GO:0035064;GO:0008270;GO:0035575;GO:0046872;GO:0051213;GO:0051864;GO:0042393;GO:0003674;GO:0005488;GO:0043169;GO:0003824;GO:0016491;GO:0016706;GO:0016705;GO:0043167;GO:0005506;GO:0005515;GO:0032451;GO:0032452;GO:0071558;GO:0032454;GO:0046914; methylated histone binding;zinc ion binding;histone demethylase activity (H4-K20 specific);metal ion binding;dioxygenase activity;histone demethylase activity (H3-K36 specific);histone binding;molecular_function;binding;cation binding;catalytic activity;oxidoreductase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;ion binding;iron ion binding;protein binding;demethylase activity;histone demethylase activity;histone demethylase activity (H3-K27 specific);histone demethylase activity (H3-K9 specific);transition metal ion binding; 5;7;5;5;4;5;4;1;2;4;2;3;5;4;3;7;3;3;4;5;5;6; K11445 IPR019787;IPR019786;IPR011011;IPR013083;IPR003347;IPR001965; Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;JmjC domain;Zinc finger, PHD-type; extracellular Hs22047606 1514.0 B [B] Chromatin structure and dynamics; Q13790 Apolipoprotein F OS=Homo sapiens OX=9606 GN=APOF PE=1 SV=2 - [APOF_HUMAN] 1.064 1.049 0.935 1.054 1.081 0.806 1.014299333 0.670327562 0.975023127 0.372998468 0.891325071 0.516711124 0.74560592 0.575079095 GO:0008202;GO:0006869;GO:0016125;GO:0044699;GO:0006066;GO:0044710;GO:0071704;GO:1901360;GO:0071702;GO:0033036;GO:0044281;GO:0006629;GO:0044238;GO:0006810;GO:1902652;GO:0044765;GO:0008150;GO:0008152;GO:0051234;GO:0010876;GO:0051179;GO:1902578;GO:0008203;GO:1901615; steroid metabolic process;lipid transport;sterol metabolic process;single-organism process;alcohol metabolic process;single-organism metabolic process;organic substance metabolic process;organic cyclic compound metabolic process;organic substance transport;macromolecule localization;small molecule metabolic process;lipid metabolic process;primary metabolic process;transport;secondary alcohol metabolic process;single-organism transport;biological_process;metabolic process;establishment of localization;lipid localization;localization;single-organism localization;cholesterol metabolic process;organic hydroxy compound metabolic process; 5;5;6;2;5;3;3;4;5;3;4;4;3;4;6;4;1;2;3;4;2;3;7;4; GO:0034358;GO:0005615;GO:0034362;GO:0034364;GO:0032994;GO:0032991;GO:0005575;GO:0005576;GO:1990777;GO:0044421; plasma lipoprotein particle;extracellular space;low-density lipoprotein particle;high-density lipoprotein particle;protein-lipid complex;macromolecular complex;cellular_component;extracellular region;lipoprotein particle;extracellular region part; 3;3;4;4;3;2;1;2;4;2; GO:0003674;GO:0005488;GO:0005319;GO:0032934;GO:0005215;GO:0008289;GO:0036094;GO:0005496;GO:0022892;GO:0015485;GO:0043178;GO:0097159;GO:0005515;GO:0005102; molecular_function;binding;lipid transporter activity;sterol binding;transporter activity;lipid binding;small molecule binding;steroid binding;substrate-specific transporter activity;cholesterol binding;alcohol binding;organic cyclic compound binding;protein binding;receptor binding; 1;2;4;5;2;3;3;4;3;6;4;3;3;4; IPR026114; Apolipoprotein F; extracellular Q6N021 Methylcytosine dioxygenase TET2 OS=Homo sapiens OX=9606 GN=TET2 PE=1 SV=3 - [TET2_HUMAN] 0.8 1.002 0.869 1.179 1.386 1.118 0.798403194 nan 0.850649351 nan 0.867265469 nan 0.806637807 nan GO:0006479;GO:0080090;GO:0019222;GO:0044281;GO:0051568;GO:1901362;GO:1901360;GO:1901361;GO:0044710;GO:0006304;GO:0019857;GO:0010604;GO:0048869;GO:0071840;GO:0019858;GO:0001822;GO:0018193;GO:0048513;GO:0048518;GO:0016571;GO:0016570;GO:0060255;GO:2001141;GO:0010033;GO:0055114;GO:0046483;GO:0070988;GO:0070989;GO:0032259;GO:1901564;GO:0044707;GO:0019538;GO:0080182;GO:0002376;GO:0018205;GO:0019438;GO:0016568;GO:0020027;GO:0018023;GO:0009891;GO:0002244;GO:0014070;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:1901575;GO:0044260;GO:0006206;GO:0018022;GO:0042592;GO:0016043;GO:0065007;GO:0007049;GO:0045893;GO:0006366;GO:0018130;GO:0009887;GO:0044270;GO:0006139;GO:0009889;GO:0050794;GO:0043412;GO:0044728;GO:0008150;GO:0008152;GO:0030097;GO:0034654;GO:0046700;GO:0002520;GO:0016070;GO:0044271;GO:0072576;GO:0061484;GO:0050896;GO:0006211;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0043414;GO:0016569;GO:1901565;GO:0032774;GO:0043413;GO:0030154;GO:0040029;GO:0009791;GO:0044249;GO:0034641;GO:0034645;GO:0009653;GO:0044699;GO:0009893;GO:0043933;GO:0034968;GO:0036211;GO:0031326;GO:0022612;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0048872;GO:0001655;GO:0006493;GO:0072001;GO:0055086;GO:0051276;GO:0080111;GO:0065008;GO:1901137;GO:1901135;GO:0051252;GO:0061008;GO:0051254;GO:0043170;GO:1902680;GO:0044723;GO:0008213;GO:0010628;GO:0045944;GO:0030099;GO:0048731;GO:0048732;GO:1903508;GO:0031328;GO:0035510;GO:0035511;GO:0031325;GO:0031323;GO:0090304;GO:0072529;GO:0001889;GO:0009100;GO:0007275;GO:0072527;GO:0006486;GO:0006325;GO:2000112;GO:0009101;GO:0071704;GO:0010467;GO:0010556;GO:0048536;GO:0048534;GO:0010468;GO:0045935;GO:0044267;GO:0019219;GO:0070085;GO:0006464;GO:0044767;GO:0009112;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0042221;GO:0009056;GO:0044248;GO:0006996;GO:0044238;GO:0005975;GO:0048856;GO:0044237;GO:1902589;GO:0002318;GO:0006259;GO:0048522; protein methylation;regulation of primary metabolic process;regulation of metabolic process;small molecule metabolic process;histone H3-K4 methylation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism metabolic process;DNA modification;5-methylcytosine metabolic process;positive regulation of macromolecule metabolic process;cellular developmental process;cellular component organization or biogenesis;cytosine metabolic process;kidney development;peptidyl-amino acid modification;animal organ development;positive regulation of biological process;histone methylation;histone modification;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;response to organic substance;oxidation-reduction process;heterocycle metabolic process;demethylation;oxidative demethylation;methylation;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;histone H3-K4 trimethylation;immune system process;peptidyl-lysine modification;aromatic compound biosynthetic process;chromatin modification;hemoglobin metabolic process;peptidyl-lysine trimethylation;positive regulation of biosynthetic process;hematopoietic progenitor cell differentiation;response to organic cyclic compound;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule metabolic process;pyrimidine nucleobase metabolic process;peptidyl-lysine methylation;homeostatic process;cellular component organization;biological regulation;cell cycle;positive regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;organ morphogenesis;cellular nitrogen compound catabolic process;nucleobase-containing compound metabolic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;DNA methylation or demethylation;biological_process;metabolic process;hemopoiesis;nucleobase-containing compound biosynthetic process;heterocycle catabolic process;immune system development;RNA metabolic process;cellular nitrogen compound biosynthetic process;liver morphogenesis;hematopoietic stem cell homeostasis;response to stimulus;5-methylcytosine catabolic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;macromolecule methylation;covalent chromatin modification;organonitrogen compound catabolic process;RNA biosynthetic process;macromolecule glycosylation;cell differentiation;regulation of gene expression, epigenetic;post-embryonic development;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;positive regulation of metabolic process;macromolecular complex subunit organization;histone lysine methylation;protein modification process;regulation of cellular biosynthetic process;gland morphogenesis;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;homeostasis of number of cells;urogenital system development;protein O-linked glycosylation;renal system development;nucleobase-containing small molecule metabolic process;chromosome organization;DNA demethylation;regulation of biological quality;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;hepaticobiliary system development;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;single-organism carbohydrate metabolic process;protein alkylation;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;myeloid cell differentiation;system development;gland development;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;DNA dealkylation;oxidative DNA demethylation;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;pyrimidine-containing compound catabolic process;liver development;glycoprotein metabolic process;multicellular organism development;pyrimidine-containing compound metabolic process;protein glycosylation;chromatin organization;regulation of cellular macromolecule biosynthetic process;glycoprotein biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;spleen development;hematopoietic or lymphoid organ development;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;glycosylation;cellular protein modification process;single-organism developmental process;nucleobase metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;catabolic process;cellular catabolic process;organelle organization;primary metabolic process;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;single-organism organelle organization;myeloid progenitor cell differentiation;DNA metabolic process;positive regulation of cellular process; 5;4;3;4;7;5;4;5;3;6;6;4;4;2;7;4;7;4;2;5;4;4;6;4;4;4;4;5;3;4;3;4;8;2;8;5;6;5;7;4;6;5;3;2;7;4;4;4;6;6;4;3;2;4;6;7;5;4;5;4;4;3;5;7;1;2;5;5;5;3;5;5;6;6;2;7;6;5;7;6;4;7;5;6;6;5;6;4;4;4;5;3;2;3;4;6;5;5;5;2;2;2;4;7;5;5;5;5;4;5;4;3;5;4;5;5;5;4;6;4;7;5;7;6;4;4;7;5;7;5;4;4;5;6;5;5;4;5;4;5;6;6;3;5;5;5;4;5;5;5;5;5;6;3;5;3;5;3;4;4;3;3;4;4;3;4;3;3;4;7;5;3; GO:1901363;GO:0046872;GO:0051213;GO:0008270;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0016491;GO:0003824;GO:0008198;GO:0097159;GO:0043169;GO:0016706;GO:0016705;GO:0043167;GO:0005506;GO:0070579;GO:0046914; heterocyclic compound binding;metal ion binding;dioxygenase activity;zinc ion binding;molecular_function;binding;nucleic acid binding;DNA binding;oxidoreductase activity;catalytic activity;ferrous iron binding;organic cyclic compound binding;cation binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;ion binding;iron ion binding;methylcytosine dioxygenase activity;transition metal ion binding; 3;5;4;7;1;2;4;5;3;2;8;3;4;5;4;3;7;6;6; IPR024779;IPR015943; 2OGFeDO, oxygenase domain;WD40/YVTN repeat-like-containing domain; endoplasmic reticulum Q9H6X2 Anthrax toxin receptor 1 OS=Homo sapiens OX=9606 GN=ANTXR1 PE=1 SV=2 - [ANTR1_HUMAN] 0.848 1.005 1.301 0.816 1.076 0.711 0.843781095 0.319647468 0.758364312 0.463164911 1.294527363 0.511808018 0.660780669 0.248079415 GO:0034446;GO:0048468;GO:0007165;GO:0071840;GO:0051716;GO:0000003;GO:0048869;GO:0031589;GO:0044700;GO:0050789;GO:0000904;GO:0000902;GO:0016043;GO:0065007;GO:0098602;GO:0050794;GO:0008150;GO:0050896;GO:0030154;GO:0023052;GO:0009653;GO:0044699;GO:0022610;GO:0032502;GO:0009987;GO:0030036;GO:0031532;GO:1902589;GO:0032989;GO:0030029;GO:0044767;GO:0022414;GO:0044763;GO:0007155;GO:0007154;GO:0006996;GO:0007010;GO:0048856; substrate adhesion-dependent cell spreading;cell development;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;reproduction;cellular developmental process;cell-substrate adhesion;single organism signaling;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;biological regulation;single organism cell adhesion;regulation of cellular process;biological_process;response to stimulus;cell differentiation;signaling;anatomical structure morphogenesis;single-organism process;biological adhesion;developmental process;cellular process;actin cytoskeleton organization;actin cytoskeleton reorganization;single-organism organelle organization;cellular component morphogenesis;actin filament-based process;single-organism developmental process;reproductive process;single-organism cellular process;cell adhesion;cell communication;organelle organization;cytoskeleton organization;anatomical structure development; 4;4;4;2;3;2;4;4;3;2;5;5;3;2;3;3;1;2;5;2;3;2;2;2;2;5;6;4;4;4;3;2;3;3;4;4;5;3; GO:0005773;GO:0016021;GO:0016020;GO:0005774;GO:0044437;GO:0098588;GO:0098589;GO:0042995;GO:0043230;GO:0043231;GO:0098858;GO:0044424;GO:0044425;GO:0044421;GO:0098590;GO:0030175;GO:0043229;GO:0043227;GO:0031224;GO:0031258;GO:0031256;GO:0031253;GO:0031252;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0044422;GO:0044440;GO:0043226;GO:0010008;GO:0005737;GO:0031090;GO:0044459;GO:0009986;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0098805;GO:0030027;GO:0005886;GO:1903561;GO:0031527;GO:0005575;GO:0005576;GO:0005768; vacuole;integral component of membrane;membrane;vacuolar membrane;vacuolar part;bounding membrane of organelle;membrane region;cell projection;extracellular organelle;intracellular membrane-bounded organelle;actin-based cell projection;intracellular part;membrane part;extracellular region part;plasma membrane region;filopodium;intracellular organelle;membrane-bounded organelle;intrinsic component of membrane;lamellipodium membrane;leading edge membrane;cell projection membrane;cell leading edge;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;organelle part;endosomal part;organelle;endosome membrane;cytoplasm;organelle membrane;plasma membrane part;cell surface;cell projection part;cell part;cell;intracellular;cell periphery;extracellular exosome;whole membrane;lamellipodium;plasma membrane;extracellular vesicle;filopodium membrane;cellular_component;extracellular region;endosome; 5;4;2;4;4;4;3;3;3;4;4;3;2;2;4;5;3;3;3;5;4;4;3;3;4;3;4;2;5;2;5;4;3;3;3;3;2;2;3;3;4;3;4;3;3;5;1;2;4; GO:0060089;GO:0046872;GO:0099600;GO:0003674;GO:0005488;GO:0003779;GO:0008092;GO:0043169;GO:0043167;GO:0032403;GO:0051015;GO:0005515;GO:0044877;GO:0005518;GO:0038023;GO:0004872;GO:0004871;GO:0004888; molecular transducer activity;metal ion binding;transmembrane receptor activity;molecular_function;binding;actin binding;cytoskeletal protein binding;cation binding;ion binding;protein complex binding;actin filament binding;protein binding;macromolecular complex binding;collagen binding;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity; 2;5;4;1;2;5;4;4;3;4;5;3;3;5;3;3;2;4; K20909 IPR013783;IPR008399;IPR002035;IPR008400; Immunoglobulin-like fold;Anthrax toxin receptor, C-terminal;von Willebrand factor, type A;Anthrax toxin receptor, extracellular; plasma membrane Q96NL6 Sodium channel and clathrin linker 1 OS=Homo sapiens OX=9606 GN=SCLT1 PE=1 SV=2 - [SCLT1_HUMAN] 0.908 1.08 1.109 0.752 1.273 1.377 0.840740741 0.302298432 0.590730558 0.021013773 1.026851852 0.742278497 1.081696779 0.503834701 GO:0048468;GO:0048469;GO:0061024;GO:0071840;GO:0048869;GO:0044707;GO:0044782;GO:0022607;GO:0021700;GO:0000902;GO:0042551;GO:0016043;GO:0048646;GO:0042384;GO:0060271;GO:0008150;GO:0045162;GO:0045161;GO:0044802;GO:0030154;GO:0010927;GO:0009653;GO:0044699;GO:0070925;GO:0032502;GO:0032501;GO:0009987;GO:0048858;GO:0048731;GO:0030030;GO:0030031;GO:0007275;GO:0032989;GO:0044085;GO:0048666;GO:0030182;GO:0044767;GO:0044763;GO:0022008;GO:0006996;GO:0048699;GO:0032990;GO:0007399;GO:0048856;GO:1902589; cell development;cell maturation;membrane organization;cellular component organization or biogenesis;cellular developmental process;single-multicellular organism process;cilium organization;cellular component assembly;developmental maturation;cell morphogenesis;neuron maturation;cellular component organization;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;biological_process;clustering of voltage-gated sodium channels;neuronal ion channel clustering;single-organism membrane organization;cell differentiation;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;single-organism process;organelle assembly;developmental process;multicellular organismal process;cellular process;cell projection morphogenesis;system development;cell projection organization;cell projection assembly;multicellular organism development;cellular component morphogenesis;cellular component biogenesis;neuron development;neuron differentiation;single-organism developmental process;single-organism cellular process;neurogenesis;organelle organization;generation of neurons;cell part morphogenesis;nervous system development;anatomical structure development;single-organism organelle organization; 4;5;4;2;4;3;5;4;4;5;6;3;3;5;6;1;6;5;4;5;4;3;2;5;2;2;2;5;4;4;5;4;4;3;5;6;3;3;6;4;7;5;5;3;4; GO:0030117;GO:0030118;GO:0031982;GO:0016020;GO:0071439;GO:0042995;GO:0043234;GO:0043230;GO:0043232;GO:0005829;GO:0048475;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0044441;GO:0005737;GO:0044450;GO:0097539;GO:0005815;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0043227;GO:0044444;GO:0005814;GO:0015630;GO:1903561;GO:0032991;GO:0005575;GO:0098796;GO:0005576;GO:0005813; membrane coat;clathrin coat;vesicle;membrane;clathrin complex;cell projection;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;coated membrane;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;ciliary part;cytoplasm;microtubule organizing center part;ciliary transition fiber;microtubule organizing center;cell projection part;cell part;cell;intracellular;extracellular exosome;membrane-bounded organelle;cytoplasmic part;centriole;microtubule cytoskeleton;extracellular vesicle;macromolecular complex;cellular_component;membrane protein complex;extracellular region;centrosome; 4;5;4;2;4;3;3;3;4;5;3;3;2;2;2;3;3;3;2;5;4;3;3;4;5;4;5;3;2;2;3;4;3;4;5;6;3;2;1;3;2;5; GO:0003674;GO:0098772;GO:0017080;GO:0016247; molecular_function;molecular function regulator;sodium channel regulator activity;channel regulator activity; 1;2;4;3; cytosol P26927 Hepatocyte growth factor-like protein OS=Homo sapiens OX=9606 GN=MST1 PE=1 SV=2 - [HGFL_HUMAN] 1.014 1.04 1.087 1.032 0.977 1.067 0.975 0.852583173 1.05629478 0.608478182 1.045192308 0.076483946 1.092118731 0.487246013 GO:0043227;GO:0043226;GO:0070062;GO:0005576;GO:1903561;GO:0031982;GO:0043230;GO:0005575;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular region;extracellular vesicle;vesicle;extracellular organelle;cellular_component;extracellular region part; 3;2;4;2;3;4;3;1;2; GO:0004252;GO:0004175;GO:0019899;GO:0003674;GO:0005488;GO:0008233;GO:0008236;GO:0030971;GO:1990782;GO:0016787;GO:0017171;GO:0019901;GO:0019900;GO:0003824;GO:0070011;GO:0005515;GO:0005102; serine-type endopeptidase activity;endopeptidase activity;enzyme binding;molecular_function;binding;peptidase activity;serine-type peptidase activity;receptor tyrosine kinase binding;protein tyrosine kinase binding;hydrolase activity;serine hydrolase activity;protein kinase binding;kinase binding;catalytic activity;peptidase activity, acting on L-amino acid peptides;protein binding;receptor binding; 6;6;4;1;2;4;5;5;7;3;4;6;5;2;5;3;4; K23441 IPR003609;IPR001254;IPR018056;IPR009003;IPR000001;IPR024174;IPR001314;IPR013806; PAN/Apple domain;Serine proteases, trypsin domain;Kringle, conserved site;Peptidase S1, PA clan;Kringle;Hepatocyte growth factor-like;Peptidase S1A, chymotrypsin family;Kringle-like fold; extracellular 159897046 98.2 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease P49747 Cartilage oligomeric matrix protein OS=Homo sapiens OX=9606 GN=COMP PE=1 SV=2 - [COMP_HUMAN] 0.7 0.903 1.999 0.672 0.758 0.688 0.775193798 nan 0.886543536 nan 2.213732004 nan 0.907651715 nan GO:0032502;GO:0048589;GO:0050789;GO:0060173;GO:0060349;GO:0060348;GO:0001501;GO:0035265;GO:0007155;GO:0008219;GO:0009653;GO:0007275;GO:0044699;GO:0010941;GO:0040007;GO:0042981;GO:0071840;GO:0016043;GO:0043062;GO:0098868;GO:0043067;GO:0048513;GO:0065007;GO:0030198;GO:0048519;GO:0003416;GO:0003417;GO:0043069;GO:0048705;GO:0060351;GO:0009887;GO:0032501;GO:0060548;GO:0006915;GO:0009888;GO:0061448;GO:0044767;GO:0012501;GO:0008150;GO:0043066;GO:0050794;GO:0051216;GO:0044707;GO:0022610;GO:0048856;GO:0044763;GO:0048523;GO:0060350;GO:0048731;GO:0009987;GO:0048736; developmental process;developmental growth;regulation of biological process;limb development;bone morphogenesis;bone development;skeletal system development;organ growth;cell adhesion;cell death;anatomical structure morphogenesis;multicellular organism development;single-organism process;regulation of cell death;growth;regulation of apoptotic process;cellular component organization or biogenesis;cellular component organization;extracellular structure organization;bone growth;regulation of programmed cell death;animal organ development;biological regulation;extracellular matrix organization;negative regulation of biological process;endochondral bone growth;growth plate cartilage development;negative regulation of programmed cell death;skeletal system morphogenesis;cartilage development involved in endochondral bone morphogenesis;organ morphogenesis;multicellular organismal process;negative regulation of cell death;apoptotic process;tissue development;connective tissue development;single-organism developmental process;programmed cell death;biological_process;negative regulation of apoptotic process;regulation of cellular process;cartilage development;single-multicellular organism process;biological adhesion;anatomical structure development;single-organism cellular process;negative regulation of cellular process;endochondral bone morphogenesis;system development;cellular process;appendage development; 2;3;2;5;5;4;5;4;3;4;3;4;2;4;2;6;2;3;4;5;5;4;2;5;2;6;5;5;5;4;4;2;4;6;4;5;3;5;1;6;3;5;3;2;3;3;3;6;4;2;4; GO:0043226;GO:0043227;GO:0005615;GO:0031982;GO:1903561;GO:0070062;GO:0043230;GO:0005578;GO:0005575;GO:0031012;GO:0005576;GO:0044421; organelle;membrane-bounded organelle;extracellular space;vesicle;extracellular vesicle;extracellular exosome;extracellular organelle;proteinaceous extracellular matrix;cellular_component;extracellular matrix;extracellular region;extracellular region part; 2;3;3;4;3;4;3;3;1;2;2;2; GO:0005201;GO:0046872;GO:0003674;GO:0005488;GO:0001948;GO:0043168;GO:0005539;GO:1901681;GO:0005198;GO:0005509;GO:0002020;GO:0032403;GO:0005515;GO:0043169;GO:0043395;GO:0043394;GO:0019899;GO:0008201;GO:0043167;GO:0097367;GO:0044877;GO:0005518; extracellular matrix structural constituent;metal ion binding;molecular_function;binding;glycoprotein binding;anion binding;glycosaminoglycan binding;sulfur compound binding;structural molecule activity;calcium ion binding;protease binding;protein complex binding;protein binding;cation binding;heparan sulfate proteoglycan binding;proteoglycan binding;enzyme binding;heparin binding;ion binding;carbohydrate derivative binding;macromolecular complex binding;collagen binding; 3;5;1;2;4;4;4;3;2;6;5;4;3;4;4;5;4;4;3;3;3;5; K04659 map04145;map04151;map04510;map04512;map05144; Phagosome;PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Malaria; IPR018097;IPR009030;IPR024665;IPR013320;IPR017897;IPR028974;IPR000742;IPR008859;IPR003367;IPR001881;IPR013032; EGF-like calcium-binding, conserved site;Growth factor receptor cysteine-rich domain;Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain;Concanavalin A-like lectin/glucanase domain;Thrombospondin, type 3 repeat;TSP type-3 repeat;EGF-like domain;Thrombospondin, C-terminal;Thrombospondin, type 3-like repeat;EGF-like calcium-binding domain;EGF-like, conserved site; extracellular Hs4557483 1525.0 W [W] Extracellular structures; P18621 60S ribosomal protein L17 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3 - [RL17_HUMAN] 1.134 0.994 1.025 1.076 0.995 0.826 1.14084507 0.185788082 1.081407035 0.158431951 1.031187123 0.799421874 0.830150754 0.568298251 GO:0044249;GO:0034641;GO:0006807;GO:0044237;GO:0034645;GO:0043170;GO:1901576;GO:0044260;GO:0043043;GO:0071704;GO:0010467;GO:0044267;GO:0009987;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:1901564;GO:0043604;GO:0044238;GO:0044271;GO:1901566;GO:0019538;GO:0043603;GO:0006518;GO:0006412; cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;peptide biosynthetic process;organic substance metabolic process;gene expression;cellular protein metabolic process;cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;organonitrogen compound metabolic process;amide biosynthetic process;primary metabolic process;cellular nitrogen compound biosynthetic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular amide metabolic process;peptide metabolic process;translation; 4;4;3;3;5;4;4;4;6;3;5;5;2;3;5;1;2;4;6;3;5;5;4;5;5;6; GO:0015934;GO:0022625;GO:1990904;GO:0043232;GO:0022626;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0044444;GO:0044445;GO:0032991;GO:0030529;GO:0044446;GO:0044391;GO:0043231;GO:0005829;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0005840;GO:0043228;GO:0044424;GO:0044422; large ribosomal subunit;cytosolic large ribosomal subunit;ribonucleoprotein complex;intracellular non-membrane-bounded organelle;cytosolic ribosome;membrane-bounded organelle;organelle;cytoplasm;nucleus;cytoplasmic part;cytosolic part;macromolecular complex;intracellular ribonucleoprotein complex;intracellular organelle part;ribosomal subunit;intracellular membrane-bounded organelle;cytosol;cell part;intracellular organelle;cell;intracellular;cellular_component;ribosome;non-membrane-bounded organelle;intracellular part;organelle part; 5;6;3;4;6;3;2;4;5;4;5;2;4;3;4;4;5;2;3;2;3;1;5;3;3;2; GO:0003676;GO:1901363;GO:0003674;GO:0005198;GO:0003735;GO:0003723;GO:0044822;GO:0097159;GO:0005488; nucleic acid binding;heterocyclic compound binding;molecular_function;structural molecule activity;structural constituent of ribosome;RNA binding;poly(A) RNA binding;organic cyclic compound binding;binding; 4;3;1;2;3;5;6;3;2; K02880 map03010; Ribosome; IPR001063;IPR005721;IPR018260; Ribosomal protein L22/L17;Ribosomal protein L22/L17, eukaryotic/archaeal;Ribosomal protein L22/L17, conserved site; cytosol Hs4506617 384.0 J [J] Translation, ribosomal structure and biogenesis; Q15365 Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2 - [PCBP1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:1990904;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0030529;GO:0032991;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; ribonucleoprotein complex;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular ribonucleoprotein complex;macromolecular complex;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;3;2;4;5;4;2;4;2;2;3;1;3; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0003697;GO:0097159;GO:0003723; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;single-stranded DNA binding;organic cyclic compound binding;RNA binding; 3;1;2;4;5;6;3;5; K12889 map03040; Spliceosome; IPR004087;IPR004088; K Homology domain;K Homology domain, type 1; cytoskeleton Hs5453854 725.0 AR [A] RNA processing and modification;[R] General function prediction only; P04275 von Willebrand factor OS=Homo sapiens OX=9606 GN=VWF PE=1 SV=4 - [VWF_HUMAN] 1.104 0.885 0.95 1.145 1.005 1.057 1.247457627 4.19E-06 1.139303483 0.00959021 1.073446328 0.052098305 1.051741294 0.321021992 GO:0007599;GO:0007597;GO:0007596;GO:0071840;GO:0044710;GO:0009611;GO:0031589;GO:0030168;GO:0016192;GO:0044707;GO:0019538;GO:0030198;GO:0022607;GO:0006887;GO:0016043;GO:0045055;GO:0065003;GO:0065007;GO:0065008;GO:0006810;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0051234;GO:0046903;GO:0050896;GO:0001775;GO:0035902;GO:0070271;GO:0044699;GO:0022610;GO:0032501;GO:0050878;GO:0009987;GO:0051259;GO:0032940;GO:0043170;GO:0043933;GO:0071822;GO:0072376;GO:0072378;GO:0002576;GO:0051260;GO:0071704;GO:0044085;GO:0043062;GO:0006461;GO:0044765;GO:0044763;GO:0007155;GO:0051179;GO:1902578;GO:0044238; hemostasis;blood coagulation, intrinsic pathway;blood coagulation;cellular component organization or biogenesis;single-organism metabolic process;response to wounding;cell-substrate adhesion;platelet activation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;extracellular matrix organization;cellular component assembly;exocytosis;cellular component organization;regulated exocytosis;macromolecular complex assembly;biological regulation;regulation of biological quality;transport;wound healing;response to stress;coagulation;biological_process;metabolic process;establishment of localization;secretion;response to stimulus;cell activation;response to immobilization stress;protein complex biogenesis;single-organism process;biological adhesion;multicellular organismal process;regulation of body fluid levels;cellular process;protein oligomerization;secretion by cell;macromolecule metabolic process;macromolecular complex subunit organization;protein complex subunit organization;protein activation cascade;blood coagulation, fibrin clot formation;platelet degranulation;protein homooligomerization;organic substance metabolic process;cellular component biogenesis;extracellular structure organization;protein complex assembly;single-organism transport;single-organism cellular process;cell adhesion;localization;single-organism localization;primary metabolic process; 5;4;5;2;3;4;4;5;5;3;4;5;4;5;3;6;5;2;3;4;5;3;4;1;2;3;5;2;4;4;4;2;2;2;4;2;6;4;4;4;5;3;4;7;7;3;3;4;5;4;3;3;2;3;3; GO:0005783;GO:0031974;GO:0044433;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0099503;GO:0033093;GO:0034774;GO:0043231;GO:0043230;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0030141;GO:0012505;GO:0044446;GO:0044444;GO:0097708;GO:0031012;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0030135;GO:0030136;GO:0070062;GO:1903561;GO:0005575;GO:0005576;GO:0005578; endoplasmic reticulum;membrane-enclosed lumen;cytoplasmic vesicle part;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;secretory vesicle;Weibel-Palade body;secretory granule lumen;intracellular membrane-bounded organelle;extracellular organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;secretory granule;endomembrane system;intracellular organelle part;cytoplasmic part;intracellular vesicle;extracellular matrix;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;coated vesicle;clathrin-coated vesicle;extracellular exosome;extracellular vesicle;cellular_component;extracellular region;proteinaceous extracellular matrix; 4;2;4;4;4;5;5;6;5;5;4;3;3;3;2;2;3;3;3;2;4;3;3;4;4;2;5;4;5;6;5;2;2;6;7;4;3;1;2;3; GO:0019865;GO:0050839;GO:0097367;GO:0003674;GO:0005488;GO:0001948;GO:0046983;GO:0019899;GO:0051087;GO:0002020;GO:0032403;GO:0042802;GO:0042803;GO:0047485;GO:0005515;GO:0044877;GO:0005102;GO:0005518;GO:0005178; immunoglobulin binding;cell adhesion molecule binding;carbohydrate derivative binding;molecular_function;binding;glycoprotein binding;protein dimerization activity;enzyme binding;chaperone binding;protease binding;protein complex binding;identical protein binding;protein homodimerization activity;protein N-terminus binding;protein binding;macromolecular complex binding;receptor binding;collagen binding;integrin binding; 5;4;3;1;2;4;4;4;4;5;4;4;5;4;3;3;4;5;5; K03900 map04151;map04510;map04512;map04610;map04611; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Complement and coagulation cascades;Platelet activation; IPR006207;IPR002919;IPR002035;IPR032361;IPR001007;IPR014853;IPR001846;IPR012011; Cystine knot, C-terminal;Trypsin Inhibitor-like, cysteine rich domain;von Willebrand factor, type A;von Willebrand factor, VWA N-terminal domain;VWFC domain;Uncharacterised domain, cysteine-rich;von Willebrand factor, type D domain;von Willebrand factor; extracellular Hs4507907 5783.0 WV [W] Extracellular structures;[V] Defense mechanisms; Q13322 Growth factor receptor-bound protein 10 OS=Homo sapiens OX=9606 GN=GRB10 PE=1 SV=2 - [GRB10_HUMAN] 0.966 0.935 1.057 1.145 0.897 1.717 1.03315508 0.519867946 1.276477146 0.024136706 1.130481283 0.148128778 1.914158305 0.002492878 GO:0019220;GO:0080090;GO:0019222;GO:0046325;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0030111;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0051234;GO:0010962;GO:0051716;GO:0044711;GO:0010605;GO:0009968;GO:0009966;GO:0009967;GO:0070848;GO:0006073;GO:0048518;GO:0048519;GO:0051051;GO:0060255;GO:0034645;GO:0043434;GO:0070873;GO:0070874;GO:0010033;GO:0055114;GO:0042325;GO:0044700;GO:0042327;GO:0042326;GO:0044249;GO:0016055;GO:0016051;GO:0045719;GO:0007154;GO:1900077;GO:1900076;GO:0009250;GO:0010243;GO:0044281;GO:0009892;GO:0009893;GO:0009890;GO:0010906;GO:0046323;GO:0048009;GO:0033692;GO:0050789;GO:1901576;GO:0044264;GO:0044262;GO:0044260;GO:0008645;GO:0008643;GO:0065007;GO:0032881;GO:0045912;GO:0009719;GO:0019318;GO:0006810;GO:0009889;GO:0044710;GO:0050794;GO:0008150;GO:0008152;GO:0044723;GO:0048010;GO:0043255;GO:0006006;GO:0044042;GO:0015980;GO:0030947;GO:0030949;GO:1901698;GO:1901699;GO:0044765;GO:0010556;GO:0006109;GO:0010558;GO:0016310;GO:0005996;GO:0023056;GO:0023057;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0090287;GO:0006112;GO:0071375;GO:0010562;GO:0010563;GO:0071495;GO:0008286;GO:0043170;GO:0044238;GO:0009987;GO:0034637;GO:0032870;GO:0010675;GO:0010677;GO:0032879;GO:0071363;GO:0009725;GO:0032885;GO:0050896;GO:0046324;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0010827;GO:0032869;GO:0032868;GO:0006091;GO:0010829;GO:0043467;GO:0071417;GO:2000112;GO:2000113;GO:0030178;GO:0015758;GO:0071704;GO:0071310;GO:0071702;GO:0045937;GO:0045936;GO:0000271;GO:0046626;GO:0046627;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:1901700;GO:1901701;GO:0005975;GO:0005977;GO:0005976;GO:0005979;GO:0005978;GO:0044237;GO:0006796;GO:1901652;GO:1901653;GO:0015749;GO:0006793;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of glucose import;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;establishment of localization;regulation of glucan biosynthetic process;cellular response to stimulus;single-organism biosynthetic process;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;response to growth factor;cellular glucan metabolic process;positive regulation of biological process;negative regulation of biological process;negative regulation of transport;regulation of macromolecule metabolic process;cellular macromolecule biosynthetic process;response to peptide hormone;regulation of glycogen metabolic process;negative regulation of glycogen metabolic process;response to organic substance;oxidation-reduction process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;negative regulation of phosphorylation;cellular biosynthetic process;Wnt signaling pathway;carbohydrate biosynthetic process;negative regulation of glycogen biosynthetic process;cell communication;negative regulation of cellular response to insulin stimulus;regulation of cellular response to insulin stimulus;glucan biosynthetic process;response to organonitrogen compound;small molecule metabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;regulation of glucose metabolic process;glucose import;insulin-like growth factor receptor signaling pathway;cellular polysaccharide biosynthetic process;regulation of biological process;organic substance biosynthetic process;cellular polysaccharide metabolic process;cellular carbohydrate metabolic process;cellular macromolecule metabolic process;hexose transport;carbohydrate transport;biological regulation;regulation of polysaccharide metabolic process;negative regulation of carbohydrate metabolic process;response to endogenous stimulus;hexose metabolic process;transport;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;biological_process;metabolic process;single-organism carbohydrate metabolic process;vascular endothelial growth factor receptor signaling pathway;regulation of carbohydrate biosynthetic process;glucose metabolic process;glucan metabolic process;energy derivation by oxidation of organic compounds;regulation of vascular endothelial growth factor receptor signaling pathway;positive regulation of vascular endothelial growth factor receptor signaling pathway;response to nitrogen compound;cellular response to nitrogen compound;single-organism transport;regulation of macromolecule biosynthetic process;regulation of carbohydrate metabolic process;negative regulation of macromolecule biosynthetic process;phosphorylation;monosaccharide metabolic process;positive regulation of signaling;negative regulation of signaling;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of cellular response to growth factor stimulus;energy reserve metabolic process;cellular response to peptide hormone stimulus;positive regulation of phosphorus metabolic process;negative regulation of phosphorus metabolic process;cellular response to endogenous stimulus;insulin receptor signaling pathway;macromolecule metabolic process;primary metabolic process;cellular process;cellular carbohydrate biosynthetic process;cellular response to hormone stimulus;regulation of cellular carbohydrate metabolic process;negative regulation of cellular carbohydrate metabolic process;regulation of localization;cellular response to growth factor stimulus;response to hormone;regulation of polysaccharide biosynthetic process;response to stimulus;regulation of glucose import;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of glucose transport;cellular response to insulin stimulus;response to insulin;generation of precursor metabolites and energy;negative regulation of glucose transport;regulation of generation of precursor metabolites and energy;cellular response to organonitrogen compound;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;negative regulation of Wnt signaling pathway;glucose transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;positive regulation of phosphate metabolic process;negative regulation of phosphate metabolic process;polysaccharide biosynthetic process;regulation of insulin receptor signaling pathway;negative regulation of insulin receptor signaling pathway;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;response to chemical;localization;single-organism localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;carbohydrate metabolic process;glycogen metabolic process;polysaccharide metabolic process;regulation of glycogen biosynthetic process;glycogen biosynthetic process;cellular metabolic process;phosphate-containing compound metabolic process;response to peptide;cellular response to peptide;monosaccharide transport;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;5;4;3;3;3;5;4;5;6;7;3;6;3;4;4;4;4;4;5;6;2;2;3;4;5;5;6;5;4;4;7;3;7;7;4;6;5;6;4;4;4;6;4;4;3;3;4;6;9;8;5;2;4;5;4;4;7;5;2;5;4;3;6;4;4;3;3;1;2;4;8;5;7;6;4;5;5;4;5;4;5;5;5;6;5;3;3;2;4;4;3;4;4;2;4;5;6;5;5;4;8;4;3;2;4;5;5;5;3;6;4;6;2;6;5;5;4;4;4;5;7;6;4;4;5;5;6;6;5;8;3;5;5;6;6;6;5;5;5;3;5;3;3;2;3;4;5;4;5;5;7;6;3;5;5;6;6;4;3;3; GO:0016020;GO:0005829;GO:0044424;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005886;GO:0005575; membrane;cytosol;intracellular part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;cell periphery;plasma membrane;cellular_component; 2;5;3;4;4;2;2;3;3;3;1; GO:0005070;GO:0005158;GO:0060090;GO:0003674;GO:0005488;GO:0030674;GO:0032403;GO:0005515;GO:0044877;GO:0005102;GO:0035591; SH3/SH2 adaptor activity;insulin receptor binding;binding, bridging;molecular_function;binding;protein binding, bridging;protein complex binding;protein binding;macromolecular complex binding;receptor binding;signaling adaptor activity; 5;5;3;1;2;4;4;3;3;4;4; K20064 IPR029071;IPR000159;IPR000980;IPR015042;IPR001849;IPR011993;IPR035037;IPR035036; Ubiquitin-related domain;Ras-associating (RA) domain;SH2 domain;BPS (Between PH and SH2) domain;Pleckstrin homology domain;PH domain-like;Grb10, SH2;Growth factor receptor-bound protein 10; nucleus Hs19923303 1197.0 T [T] Signal transduction mechanisms; Q15776 Zinc finger protein with KRAB and SCAN domains 8 OS=Homo sapiens OX=9606 GN=ZKSCAN8 PE=1 SV=2 - [ZKSC8_HUMAN] 0.742 1.156 1.626 0.867 0.702 0.894 0.641868512 nan 1.235042735 nan 1.406574394 nan 1.273504274 nan GO:0032774;GO:0044237;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:1901576;GO:0043170;GO:0097659;GO:0044260;GO:1901362;GO:0071704;GO:0010467;GO:1901360;GO:0018130;GO:0009987;GO:0006725;GO:0009058;GO:0034645;GO:0009059;GO:0008150;GO:0008152;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0034641;GO:0006351;GO:0019438; RNA biosynthetic process;cellular metabolic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;organic substance biosynthetic process;macromolecule metabolic process;nucleic acid-templated transcription;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;organic substance metabolic process;gene expression;organic cyclic compound metabolic process;heterocycle biosynthetic process;cellular process;cellular aromatic compound metabolic process;biosynthetic process;cellular macromolecule biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound metabolic process;transcription, DNA-templated;aromatic compound biosynthetic process; 6;3;4;5;4;3;4;4;7;4;5;3;5;4;5;2;4;3;5;5;1;2;5;4;5;3;5;4;6;5; GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;4;2;2;3;1;3; GO:1901363;GO:0003674;GO:0001071;GO:0003676;GO:0003677;GO:0043565;GO:0043167;GO:0046872;GO:0043169;GO:0003700;GO:0097159;GO:0005488; heterocyclic compound binding;molecular_function;nucleic acid binding transcription factor activity;nucleic acid binding;DNA binding;sequence-specific DNA binding;ion binding;metal ion binding;cation binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;binding; 3;1;2;4;5;6;3;5;4;3;3;2; K09229 IPR013087;IPR008916;IPR003309;IPR001909; Zinc finger C2H2-type;Retrovirus capsid, C-terminal;SCAN domain;Krueppel-associated box; nucleus Hs5454178 1186.0 R [R] General function prediction only; P0C0L5 Complement C4-B OS=Homo sapiens OX=9606 GN=C4B PE=1 SV=2 - [CO4B_HUMAN] 0.989 1.046 0.97 1.075 1.042 1.209 0.945506692 0.213111796 1.031669866 0.123472591 0.927342256 0.019993999 1.160268714 0.015281519 GO:0009595;GO:0006909;GO:0080090;GO:0019222;GO:0051049;GO:0048584;GO:0048583;GO:0016043;GO:0009593;GO:0002455;GO:0031347;GO:0044710;GO:0043207;GO:0050727;GO:0048518;GO:0065007;GO:2000425;GO:0019724;GO:0098581;GO:0051050;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0009607;GO:0051128;GO:0051707;GO:0010033;GO:0016192;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0032490;GO:0050789;GO:0009605;GO:0002684;GO:0002682;GO:0071840;GO:0051130;GO:0006810;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0002526;GO:0006958;GO:0051234;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0008228;GO:0002697;GO:0006956;GO:1903317;GO:0009617;GO:0006954;GO:0032101;GO:0009611;GO:0043277;GO:0044699;GO:0050766;GO:0050764;GO:0006959;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0060627;GO:2000427;GO:0016485;GO:0051606;GO:0032879;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0002237;GO:0080134;GO:0072376;GO:0071704;GO:0010467;GO:0051704;GO:0010468;GO:0045087;GO:0002449;GO:0044765;GO:0042221;GO:0002443;GO:0030100;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0045807;GO:0048522; detection of biotic stimulus;phagocytosis;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;cellular component organization;detection of chemical stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;response to external biotic stimulus;regulation of inflammatory response;positive regulation of biological process;biological regulation;regulation of apoptotic cell clearance;B cell mediated immunity;detection of external biotic stimulus;positive regulation of transport;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to biotic stimulus;regulation of cellular component organization;response to other organism;response to organic substance;vesicle-mediated transport;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;detection of molecule of bacterial origin;regulation of biological process;response to external stimulus;positive regulation of immune system process;regulation of immune system process;cellular component organization or biogenesis;positive regulation of cellular component organization;transport;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;acute inflammatory response;complement activation, classical pathway;establishment of localization;regulation of protein processing;endocytosis;protein maturation;response to stimulus;opsonization;regulation of immune effector process;complement activation;regulation of protein maturation;response to bacterium;inflammatory response;regulation of response to external stimulus;response to wounding;apoptotic cell clearance;single-organism process;positive regulation of phagocytosis;regulation of phagocytosis;humoral immune response;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;regulation of vesicle-mediated transport;positive regulation of apoptotic cell clearance;protein processing;detection of stimulus;regulation of localization;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;response to molecule of bacterial origin;regulation of response to stress;protein activation cascade;organic substance metabolic process;gene expression;multi-organism process;regulation of gene expression;innate immune response;lymphocyte mediated immunity;single-organism transport;response to chemical;leukocyte mediated immunity;regulation of endocytosis;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;positive regulation of endocytosis;positive regulation of cellular process; 4;5;4;3;4;3;3;3;4;5;5;3;4;5;2;2;7;6;5;3;4;4;6;6;3;4;3;4;5;4;2;5;5;5;2;3;3;3;2;4;4;3;4;3;7;1;2;3;6;5;3;7;6;5;2;4;4;4;6;4;5;4;4;6;2;5;6;4;5;5;5;2;4;6;6;3;3;4;5;4;4;5;4;3;3;5;2;5;4;5;4;3;4;5;2;3;3;4;3;3;4;3; GO:0031982;GO:0016020;GO:0043230;GO:0044217;GO:0044216;GO:0044215;GO:0044421;GO:0072562;GO:0044464;GO:0005623;GO:0071944;GO:0005615;GO:0043227;GO:0043226;GO:1903561;GO:0005886;GO:0070062;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;other organism part;other organism cell;other organism;extracellular region part;blood microparticle;cell part;cell;cell periphery;extracellular space;membrane-bounded organelle;organelle;extracellular vesicle;plasma membrane;extracellular exosome;cellular_component;extracellular region; 4;2;3;2;3;2;2;3;2;2;3;3;3;2;3;3;4;1;2; GO:0098772;GO:0004866;GO:0061135;GO:0003674;GO:0005488;GO:0001848;GO:0030234;GO:0004857;GO:0030414;GO:0005515;GO:0030246;GO:0061134; molecular function regulator;endopeptidase inhibitor activity;endopeptidase regulator activity;molecular_function;binding;complement binding;enzyme regulator activity;enzyme inhibitor activity;peptidase inhibitor activity;protein binding;carbohydrate binding;peptidase regulator activity; 2;6;5;1;2;4;3;4;5;3;3;4; K03989 map04610;map05133;map05150;map05322; Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus; IPR008930;IPR013783;IPR009048;IPR000020;IPR008993;IPR018933;IPR019742;IPR001134;IPR001599;IPR011625;IPR011626;IPR002890;IPR018081;IPR001840;IPR019565; Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;Immunoglobulin-like fold;Alpha-macroglobulin, receptor-binding;Anaphylatoxin/fibulin;Tissue inhibitor of metalloproteinases-like, OB-fold;Netrin module, non-TIMP type;Alpha-2-macroglobulin, conserved site;Netrin domain;Alpha-2-macroglobulin;Alpha-2-macroglobulin, N-terminal 2;Alpha-macroglobulin complement component;Alpha-2-macroglobulin, N-terminal;Anaphylatoxin, complement system;Anaphylatoxin, complement system domain;Alpha-2-macroglobulin, thiol-ester bond-forming; extracellular Hs4502501 3601.0 O [O] Posttranslational modification, protein turnover, chaperones; P04278 Sex hormone-binding globulin OS=Homo sapiens OX=9606 GN=SHBG PE=1 SV=2 - [SHBG_HUMAN] 0.91 1.026 0.952 0.954 1.042 1.181 0.886939571 0.038203232 0.915547025 0.063385796 0.927875244 0.636819127 1.133397313 0.178392735 GO:0043230;GO:0070062;GO:0044421;GO:0043226;GO:0005575;GO:0005576;GO:1903561;GO:0043227;GO:0031982; extracellular organelle;extracellular exosome;extracellular region part;organelle;cellular_component;extracellular region;extracellular vesicle;membrane-bounded organelle;vesicle; 3;4;2;2;1;2;3;3;4; GO:0097159;GO:0008289;GO:0003674;GO:0005488;GO:0005496;GO:0005497;GO:0042562; organic cyclic compound binding;lipid binding;molecular_function;binding;steroid binding;androgen binding;hormone binding; 3;3;1;2;4;4;3; IPR013320;IPR001791; Concanavalin A-like lectin/glucanase domain;Laminin G domain; extracellular Q5VV17 OTU domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OTUD1 PE=1 SV=1 - [OTUD1_HUMAN] 0.684 0.585 0.447 0.643 0.432 9.57 1.169230769 nan 1.488425926 nan 0.764102564 nan 22.15277778 nan GO:0044267;GO:0044260;GO:0070647;GO:0070646;GO:0071704;GO:0006508;GO:0016579;GO:0070536;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0044237;GO:0043170; cellular protein metabolic process;cellular macromolecule metabolic process;protein modification by small protein conjugation or removal;protein modification by small protein removal;organic substance metabolic process;proteolysis;protein deubiquitination;protein K63-linked deubiquitination;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;cellular metabolic process;macromolecule metabolic process; 5;4;7;6;3;5;7;8;2;6;5;5;1;2;3;4;3;4; GO:0101005;GO:0003674;GO:0008233;GO:0008234;GO:0019783;GO:0036459;GO:0016787;GO:0003824;GO:0004843;GO:0070011; ubiquitinyl hydrolase activity;molecular_function;peptidase activity;cysteine-type peptidase activity;ubiquitin-like protein-specific protease activity;thiol-dependent ubiquitinyl hydrolase activity;hydrolase activity;catalytic activity;thiol-dependent ubiquitin-specific protease activity;peptidase activity, acting on L-amino acid peptides; 4;1;4;6;7;5;3;2;6;5; K13716 IPR003323; OTU domain; cytosol, nucleus Hs20470952 651.0 TO [T] Signal transduction mechanisms;[O] Posttranslational modification, protein turnover, chaperones; P23142 Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1 PE=1 SV=4 - [FBLN1_HUMAN] 1.07 0.933 1.06 1.047 0.914 1.156 1.146838156 0.021601048 1.145514223 0.024683839 1.136120043 0.007065689 1.264770241 0.018923726 GO:0043408;GO:1904187;GO:0008104;GO:0007599;GO:0019222;GO:0034446;GO:0051048;GO:0051049;GO:0048585;GO:0007596;GO:0048468;GO:1904188;GO:0007162;GO:0038044;GO:0019220;GO:0032989;GO:0071840;GO:0080090;GO:0044710;GO:0010605;GO:0010604;GO:0009968;GO:0045785;GO:0009966;GO:0048869;GO:0000165;GO:0009611;GO:0044419;GO:0032268;GO:0051817;GO:0010721;GO:0048518;GO:0048519;GO:0030155;GO:0042127;GO:0006931;GO:0031589;GO:0030154;GO:0051051;GO:0060255;GO:0048583;GO:0043062;GO:0045184;GO:0044702;GO:0051701;GO:0051704;GO:0042325;GO:0044700;GO:0044703;GO:0016477;GO:0044707;GO:0048870;GO:0019538;GO:0044706;GO:0051272;GO:0007565;GO:0023052;GO:0007165;GO:0022604;GO:0009892;GO:0009893;GO:0022603;GO:0006468;GO:0006929;GO:0019087;GO:0032940;GO:0010628;GO:0035556;GO:0051223;GO:0051224;GO:0050789;GO:0044267;GO:0000904;GO:0050708;GO:0000902;GO:0044260;GO:0010646;GO:0050707;GO:0016043;GO:0009306;GO:0030198;GO:0065007;GO:0043409;GO:1904237;GO:2000647;GO:1904235;GO:0065008;GO:0070201;GO:0098602;GO:0050793;GO:0050792;GO:0006810;GO:0016310;GO:0051716;GO:0042060;GO:0050794;GO:0023014;GO:0050709;GO:0006950;GO:0050817;GO:0008150;GO:0006464;GO:0008152;GO:1902532;GO:0051234;GO:0051174;GO:0046903;GO:0050710;GO:0043903;GO:0043412;GO:0050896;GO:0043900;GO:0043901;GO:2000145;GO:0070371;GO:2000147;GO:2000146;GO:0051046;GO:0044003;GO:0051241;GO:0051239;GO:0051246;GO:0048146;GO:0048145;GO:0048144;GO:0051129;GO:0051128;GO:0023057;GO:1903531;GO:1903530;GO:1902531;GO:0023051;GO:1904950;GO:0009653;GO:0000003;GO:0044699;GO:0032880;GO:0051248;GO:0042326;GO:1900024;GO:1900025;GO:0006928;GO:0060284;GO:0010769;GO:0036211;GO:0031399;GO:0022610;GO:0072091;GO:0008284;GO:0008285;GO:0032501;GO:0050878;GO:0008283;GO:0031323;GO:0009987;GO:0051271;GO:0045596;GO:0045595;GO:0051270;GO:0032879;GO:0051093;GO:0032269;GO:0033036;GO:0007566;GO:0043170;GO:0001816;GO:0001817;GO:0051674;GO:0010771;GO:0072089;GO:0070373;GO:0031400;GO:0001818;GO:0032502;GO:0060341;GO:0031324;GO:0019048;GO:0070372;GO:0007275;GO:0050663;GO:0022414;GO:0072376;GO:0072378;GO:0071704;GO:0010467;GO:0071702;GO:0010468;GO:2001201;GO:0030335;GO:2001202;GO:0045936;GO:0010810;GO:0010811;GO:0010812;GO:0030334;GO:0044767;GO:0048525;GO:0044765;GO:0044764;GO:0044763;GO:0007155;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0040013;GO:0040012;GO:0040017;GO:0010563;GO:0048856;GO:0044237;GO:0006796;GO:0010648;GO:0016032;GO:0006793;GO:0015031;GO:0044403;GO:0001933;GO:0001932;GO:0035821;GO:0048523;GO:0048522; regulation of MAPK cascade;regulation of transformation of host cell by virus;protein localization;hemostasis;regulation of metabolic process;substrate adhesion-dependent cell spreading;negative regulation of secretion;regulation of transport;negative regulation of response to stimulus;blood coagulation;cell development;negative regulation of transformation of host cell by virus;negative regulation of cell adhesion;transforming growth factor-beta secretion;regulation of phosphate metabolic process;cellular component morphogenesis;cellular component organization or biogenesis;regulation of primary metabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;positive regulation of cell adhesion;regulation of signal transduction;cellular developmental process;MAPK cascade;response to wounding;interspecies interaction between organisms;regulation of cellular protein metabolic process;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell adhesion;regulation of cell proliferation;substrate-dependent cell migration, cell attachment to substrate;cell-substrate adhesion;cell differentiation;negative regulation of transport;regulation of macromolecule metabolic process;regulation of response to stimulus;extracellular structure organization;establishment of protein localization;single organism reproductive process;interaction with host;multi-organism process;regulation of phosphorylation;single organism signaling;multi-organism reproductive process;cell migration;single-multicellular organism process;cell motility;protein metabolic process;multi-multicellular organism process;positive regulation of cellular component movement;female pregnancy;signaling;signal transduction;regulation of cell morphogenesis;negative regulation of metabolic process;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;protein phosphorylation;substrate-dependent cell migration;transformation of host cell by virus;secretion by cell;positive regulation of gene expression;intracellular signal transduction;regulation of protein transport;negative regulation of protein transport;regulation of biological process;cellular protein metabolic process;cell morphogenesis involved in differentiation;regulation of protein secretion;cell morphogenesis;cellular macromolecule metabolic process;regulation of cell communication;regulation of cytokine secretion;cellular component organization;protein secretion;extracellular matrix organization;biological regulation;negative regulation of MAPK cascade;positive regulation of substrate-dependent cell migration, cell attachment to substrate;negative regulation of stem cell proliferation;regulation of substrate-dependent cell migration, cell attachment to substrate;regulation of biological quality;regulation of establishment of protein localization;single organism cell adhesion;regulation of developmental process;regulation of viral process;transport;phosphorylation;cellular response to stimulus;wound healing;regulation of cellular process;signal transduction by protein phosphorylation;negative regulation of protein secretion;response to stress;coagulation;biological_process;cellular protein modification process;metabolic process;negative regulation of intracellular signal transduction;establishment of localization;regulation of phosphorus metabolic process;secretion;negative regulation of cytokine secretion;regulation of symbiosis, encompassing mutualism through parasitism;macromolecule modification;response to stimulus;regulation of multi-organism process;negative regulation of multi-organism process;regulation of cell motility;ERK1 and ERK2 cascade;positive regulation of cell motility;negative regulation of cell motility;regulation of secretion;modification by symbiont of host morphology or physiology;negative regulation of multicellular organismal process;regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of fibroblast proliferation;regulation of fibroblast proliferation;fibroblast proliferation;negative regulation of cellular component organization;regulation of cellular component organization;negative regulation of signaling;negative regulation of secretion by cell;regulation of secretion by cell;regulation of intracellular signal transduction;regulation of signaling;negative regulation of establishment of protein localization;anatomical structure morphogenesis;reproduction;single-organism process;regulation of protein localization;negative regulation of protein metabolic process;negative regulation of phosphorylation;regulation of substrate adhesion-dependent cell spreading;negative regulation of substrate adhesion-dependent cell spreading;movement of cell or subcellular component;regulation of cell development;regulation of cell morphogenesis involved in differentiation;protein modification process;regulation of protein modification process;biological adhesion;regulation of stem cell proliferation;positive regulation of cell proliferation;negative regulation of cell proliferation;multicellular organismal process;regulation of body fluid levels;cell proliferation;regulation of cellular metabolic process;cellular process;negative regulation of cellular component movement;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cellular component movement;regulation of localization;negative regulation of developmental process;negative regulation of cellular protein metabolic process;macromolecule localization;embryo implantation;macromolecule metabolic process;cytokine production;regulation of cytokine production;localization of cell;negative regulation of cell morphogenesis involved in differentiation;stem cell proliferation;negative regulation of ERK1 and ERK2 cascade;negative regulation of protein modification process;negative regulation of cytokine production;developmental process;regulation of cellular localization;negative regulation of cellular metabolic process;modulation by virus of host morphology or physiology;regulation of ERK1 and ERK2 cascade;multicellular organism development;cytokine secretion;reproductive process;protein activation cascade;blood coagulation, fibrin clot formation;organic substance metabolic process;gene expression;organic substance transport;regulation of gene expression;regulation of transforming growth factor-beta secretion;positive regulation of cell migration;negative regulation of transforming growth factor-beta secretion;negative regulation of phosphate metabolic process;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;negative regulation of cell-substrate adhesion;regulation of cell migration;single-organism developmental process;negative regulation of viral process;single-organism transport;multi-organism cellular process;single-organism cellular process;cell adhesion;cell communication;localization;single-organism localization;cellular localization;locomotion;primary metabolic process;negative regulation of locomotion;regulation of locomotion;positive regulation of locomotion;negative regulation of phosphorus metabolic process;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;negative regulation of cell communication;viral process;phosphorus metabolic process;protein transport;symbiosis, encompassing mutualism through parasitism;negative regulation of protein phosphorylation;regulation of protein phosphorylation;modification of morphology or physiology of other organism;negative regulation of cellular process;positive regulation of cellular process; 6;4;4;5;3;4;4;4;3;5;4;5;4;6;6;4;2;4;3;4;4;4;4;4;4;5;4;3;5;4;5;2;2;4;4;5;4;5;3;4;3;4;4;3;4;2;7;3;3;4;3;3;4;3;4;4;2;4;5;3;3;4;7;5;6;4;5;5;5;4;2;5;5;6;5;4;4;5;3;5;5;2;6;6;5;6;3;5;3;3;4;4;6;3;5;3;4;5;3;4;1;6;2;5;3;5;5;5;4;5;2;3;3;4;6;4;4;5;5;3;3;5;5;5;4;4;4;3;4;5;5;3;3;3;2;2;4;5;7;5;5;4;5;6;5;6;2;5;4;4;2;4;3;4;2;4;4;4;4;3;3;5;3;4;4;4;4;3;5;4;7;6;4;2;4;4;5;7;4;5;2;3;4;3;5;5;5;6;5;6;6;5;5;5;5;3;4;4;3;3;3;4;2;3;3;2;3;3;3;3;5;3;3;5;4;4;4;5;4;7;7;3;3;3; GO:0043230;GO:0044420;GO:0044421;GO:0031982;GO:0031012;GO:0043227;GO:0043226;GO:0071953;GO:0070062;GO:0005604;GO:0005615;GO:1903561;GO:0005578;GO:0005575;GO:0005576; extracellular organelle;extracellular matrix component;extracellular region part;vesicle;extracellular matrix;membrane-bounded organelle;organelle;elastic fiber;extracellular exosome;basement membrane;extracellular space;extracellular vesicle;proteinaceous extracellular matrix;cellular_component;extracellular region; 3;2;2;4;2;3;2;3;4;3;3;3;3;1;2; GO:0016504;GO:0046872;GO:0050839;GO:0003674;GO:0005488;GO:0098772;GO:0030234;GO:0001968;GO:0005102;GO:0070051;GO:0008022;GO:0043169;GO:0043167;GO:0005509;GO:0032403;GO:0042802;GO:0005515;GO:0044877;GO:0005201;GO:0008047;GO:0005198;GO:0005178;GO:0061134; peptidase activator activity;metal ion binding;cell adhesion molecule binding;molecular_function;binding;molecular function regulator;enzyme regulator activity;fibronectin binding;receptor binding;fibrinogen binding;protein C-terminus binding;cation binding;ion binding;calcium ion binding;protein complex binding;identical protein binding;protein binding;macromolecular complex binding;extracellular matrix structural constituent;enzyme activator activity;structural molecule activity;integrin binding;peptidase regulator activity; 5;5;4;1;2;2;3;4;4;5;4;4;3;6;4;4;3;3;3;4;2;5;4; K17307 IPR000152;IPR018097;IPR000020;IPR017048;IPR009030;IPR000742;IPR026823;IPR001881;IPR013032; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Anaphylatoxin/fibulin;Fibulin-1;Growth factor receptor cysteine-rich domain;EGF-like domain;Complement Clr-like EGF domain;EGF-like calcium-binding domain;EGF-like, conserved site; extracellular Hs5922009 1424.0 T [T] Signal transduction mechanisms; Q6ZV73 FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens OX=9606 GN=FGD6 PE=1 SV=2 - [FGD6_HUMAN] 0.989 1.133 0.874 1.003 1.178 0.84 0.872903795 0.779713328 0.851443124 0.928539695 0.771403354 0.757373858 0.713073005 0.078527789 GO:0048583;GO:0007165;GO:0071840;GO:0051716;GO:0009966;GO:0048869;GO:0044093;GO:0051056;GO:0008360;GO:0044700;GO:0007154;GO:0046847;GO:0022604;GO:0022607;GO:0022603;GO:0023051;GO:0035556;GO:0010646;GO:0043547;GO:0051345;GO:0016043;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0050793;GO:0050790;GO:0050794;GO:0008150;GO:1902531;GO:0051336;GO:0050896;GO:0046578;GO:0051128;GO:0023052;GO:0035023;GO:0009653;GO:0043087;GO:0044699;GO:0032502;GO:0009987;GO:0030030;GO:0030031;GO:0030036;GO:0050789;GO:0030029;GO:0044767;GO:0044763;GO:0007266;GO:0007265;GO:0007264;GO:0000902;GO:0006996;GO:0007010;GO:0048856;GO:1902589;GO:0044085;GO:0032989; regulation of response to stimulus;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;regulation of signal transduction;cellular developmental process;positive regulation of molecular function;regulation of small GTPase mediated signal transduction;regulation of cell shape;single organism signaling;cell communication;filopodium assembly;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;regulation of signaling;intracellular signal transduction;regulation of cell communication;positive regulation of GTPase activity;positive regulation of hydrolase activity;cellular component organization;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;regulation of developmental process;regulation of catalytic activity;regulation of cellular process;biological_process;regulation of intracellular signal transduction;regulation of hydrolase activity;response to stimulus;regulation of Ras protein signal transduction;regulation of cellular component organization;signaling;regulation of Rho protein signal transduction;anatomical structure morphogenesis;regulation of GTPase activity;single-organism process;developmental process;cellular process;cell projection organization;cell projection assembly;actin cytoskeleton organization;regulation of biological process;actin filament-based process;single-organism developmental process;single-organism cellular process;Rho protein signal transduction;Ras protein signal transduction;small GTPase mediated signal transduction;cell morphogenesis;organelle organization;cytoskeleton organization;anatomical structure development;single-organism organelle organization;cellular component biogenesis;cellular component morphogenesis; 3;4;2;3;4;4;4;6;4;3;4;6;5;4;4;3;5;4;7;6;3;2;5;3;3;3;4;3;1;5;5;2;7;4;2;8;3;6;2;2;2;4;5;5;2;4;3;3;8;7;6;5;4;5;3;4;3;4; GO:0042995;GO:0043231;GO:0043232;GO:0044424;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0031252;GO:0012505;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005794;GO:0001726;GO:0030027;GO:0005575; cell projection;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cell leading edge;endomembrane system;cytoplasmic part;cytoplasm;cell part;cell;intracellular;Golgi apparatus;ruffle;lamellipodium;cellular_component; 3;4;4;3;3;3;3;2;5;3;3;4;4;2;2;3;4;4;4;1; GO:0031267;GO:0098772;GO:0046872;GO:0005088;GO:0005085;GO:0003674;GO:0005488;GO:0005089;GO:0019899;GO:0043169;GO:0043167;GO:0051020;GO:0005515; small GTPase binding;molecular function regulator;metal ion binding;Ras guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;molecular_function;binding;Rho guanyl-nucleotide exchange factor activity;enzyme binding;cation binding;ion binding;GTPase binding;protein binding; 6;2;5;4;3;1;2;5;4;4;3;5;3; K05724 IPR000219;IPR013083;IPR000306;IPR017455;IPR011993;IPR001849; Dbl homology (DH) domain;Zinc finger, RING/FYVE/PHD-type;FYVE zinc finger;Zinc finger, FYVE-related;PH domain-like;Pleckstrin homology domain; nucleus Hs8922921 915.0 R [R] General function prediction only; A0A0B4J1X8 Immunoglobulin heavy variable 3-43 OS=Homo sapiens OX=9606 GN=IGHV3-43 PE=3 SV=1 - [HV343_HUMAN] 0.936 1.099 1.005 0.999 0.911 1.287 0.851683348 0.274788025 1.096597146 0.635479019 0.914467698 0.936584384 1.41273326 0.188757253 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q14964 Ras-related protein Rab-39A OS=Homo sapiens OX=9606 GN=RAB39A PE=1 SV=2 - [RB39A_HUMAN] 0.855 1.002 1.048 0.97 1.029 1.992 0.853293413 nan 0.942662779 nan 1.045908184 nan 1.935860058 nan GO:0008104;GO:0006909;GO:0006906;GO:0061025;GO:0061024;GO:0007165;GO:0098771;GO:0071840;GO:0051716;GO:0033036;GO:0019725;GO:0045851;GO:0007033;GO:0007264;GO:0045184;GO:0044700;GO:0016192;GO:0090174;GO:0016050;GO:0048878;GO:0050789;GO:0022607;GO:0035556;GO:0006885;GO:0016043;GO:0065007;GO:0065008;GO:0001845;GO:0006810;GO:0050794;GO:0044802;GO:0044801;GO:0051234;GO:0006897;GO:0050896;GO:0008150;GO:0050801;GO:0023052;GO:0007040;GO:0051453;GO:0051452;GO:0044699;GO:0009987;GO:0006873;GO:0030004;GO:0030003;GO:0055080;GO:0055082;GO:0042592;GO:0030641;GO:0090385;GO:0090382;GO:0090383;GO:0080171;GO:0071702;GO:0006914;GO:0044765;GO:0044763;GO:0055067;GO:0007154;GO:0070925;GO:0051179;GO:1902578;GO:0006996;GO:1902589;GO:0044085;GO:0048284;GO:0015031; protein localization;phagocytosis;vesicle fusion;membrane fusion;membrane organization;signal transduction;inorganic ion homeostasis;cellular component organization or biogenesis;cellular response to stimulus;macromolecule localization;cellular homeostasis;pH reduction;vacuole organization;small GTPase mediated signal transduction;establishment of protein localization;single organism signaling;vesicle-mediated transport;organelle membrane fusion;vesicle organization;chemical homeostasis;regulation of biological process;cellular component assembly;intracellular signal transduction;regulation of pH;cellular component organization;biological regulation;regulation of biological quality;phagolysosome assembly;transport;regulation of cellular process;single-organism membrane organization;single-organism membrane fusion;establishment of localization;endocytosis;response to stimulus;biological_process;ion homeostasis;signaling;lysosome organization;regulation of intracellular pH;intracellular pH reduction;single-organism process;cellular process;cellular ion homeostasis;cellular monovalent inorganic cation homeostasis;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;homeostatic process;regulation of cellular pH;phagosome-lysosome fusion;phagosome maturation;phagosome acidification;lytic vacuole organization;organic substance transport;autophagy;single-organism transport;single-organism cellular process;monovalent inorganic cation homeostasis;cell communication;organelle assembly;localization;single-organism localization;organelle organization;single-organism organelle organization;cellular component biogenesis;organelle fusion;protein transport; 4;5;6;5;4;4;7;2;3;3;4;10;5;6;4;3;5;5;5;5;2;4;5;9;3;2;3;6;4;3;4;5;3;6;2;1;6;2;7;10;11;2;2;6;8;7;7;5;4;9;7;5;6;6;5;3;4;3;8;4;5;2;3;4;4;3;5;5; GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0045335;GO:0012505;GO:0012506;GO:0030670;GO:0044446;GO:0005773;GO:0044444;GO:0097708;GO:0000323;GO:0005737;GO:0030666;GO:0031090;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0030139;GO:0071944;GO:0005764;GO:0098805;GO:0005886;GO:0030659;GO:0005575; vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;phagocytic vesicle;endomembrane system;vesicle membrane;phagocytic vesicle membrane;intracellular organelle part;vacuole;cytoplasmic part;intracellular vesicle;lytic vacuole;cytoplasm;endocytic vesicle membrane;organelle membrane;cytoplasmic vesicle;cell part;cell;intracellular;endocytic vesicle;cell periphery;lysosome;whole membrane;plasma membrane;cytoplasmic vesicle membrane;cellular_component; 4;5;2;5;4;4;4;3;2;3;3;2;4;7;3;4;5;3;5;4;4;6;4;4;3;5;2;2;3;6;3;7;3;3;5;1; GO:1901363;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0043168;GO:0097159;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0000166;GO:0043167;GO:0032561;GO:0001882;GO:0019001;GO:0001883;GO:0036094; heterocyclic compound binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;anion binding;organic cyclic compound binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;ion binding;guanyl ribonucleotide binding;nucleoside binding;guanyl nucleotide binding;purine nucleoside binding;small molecule binding; 3;3;1;2;4;5;5;6;4;3;5;6;4;5;4;3;6;4;6;5;3; K07924 IPR005225;IPR027417;IPR001806; Small GTP-binding protein domain;P-loop containing nucleoside triphosphate hydrolase;Small GTPase superfamily; cytosol Hs18604537 450.0 R [R] General function prediction only; Q92887 Canalicular multispecific organic anion transporter 1 OS=Homo sapiens OX=9606 GN=ABCC2 PE=1 SV=3 - [MRP2_HUMAN] 0.953 1 0.983 0.83 1.071 2.152 0.953 nan 0.774976657 nan 0.983 nan 2.009337068 nan GO:0006820;GO:0055081;GO:0098771;GO:0006979;GO:0033036;GO:0019725;GO:0015718;GO:0015849;GO:0015711;GO:0010876;GO:0010033;GO:0010243;GO:0048878;GO:0072337;GO:1901571;GO:0065007;GO:0014070;GO:0065008;GO:0015908;GO:0006811;GO:0006810;GO:0006950;GO:0008150;GO:0009266;GO:0051234;GO:1901698;GO:0055064;GO:0006869;GO:0050896;GO:0050801;GO:0044699;GO:0009719;GO:0009987;GO:0006873;GO:0001101;GO:0030002;GO:0009408;GO:0055082;GO:0055083;GO:0055085;GO:0009725;GO:0031427;GO:0042493;GO:0071715;GO:0048545;GO:0030320;GO:0042592;GO:0030644;GO:0015893;GO:0033993;GO:0071705;GO:0071702;GO:0046685;GO:0006855;GO:0015732;GO:0070327;GO:0010817;GO:0044765;GO:0044763;GO:0043627;GO:0042221;GO:0051179;GO:1902578;GO:0046942;GO:1901700;GO:0009628;GO:0009914; anion transport;anion homeostasis;inorganic ion homeostasis;response to oxidative stress;macromolecule localization;cellular homeostasis;monocarboxylic acid transport;organic acid transport;organic anion transport;lipid localization;response to organic substance;response to organonitrogen compound;chemical homeostasis;modified amino acid transport;fatty acid derivative transport;biological regulation;response to organic cyclic compound;regulation of biological quality;fatty acid transport;ion transport;transport;response to stress;biological_process;response to temperature stimulus;establishment of localization;response to nitrogen compound;chloride ion homeostasis;lipid transport;response to stimulus;ion homeostasis;single-organism process;response to endogenous stimulus;cellular process;cellular ion homeostasis;response to acid chemical;cellular anion homeostasis;response to heat;cellular chemical homeostasis;monovalent inorganic anion homeostasis;transmembrane transport;response to hormone;response to methotrexate;response to drug;icosanoid transport;response to steroid hormone;cellular monovalent inorganic anion homeostasis;homeostatic process;cellular chloride ion homeostasis;drug transport;response to lipid;nitrogen compound transport;organic substance transport;response to arsenic-containing substance;drug transmembrane transport;prostaglandin transport;thyroid hormone transport;regulation of hormone levels;single-organism transport;single-organism cellular process;response to estrogen;response to chemical;localization;single-organism localization;carboxylic acid transport;response to oxygen-containing compound;response to abiotic stimulus;hormone transport; 6;7;7;4;3;4;7;5;6;4;4;4;5;6;5;2;5;3;6;5;4;3;1;4;3;4;9;5;2;6;2;3;2;6;4;7;4;5;8;4;4;5;4;6;5;8;4;9;5;5;5;5;4;5;7;6;4;4;3;6;3;2;3;6;4;3;5; GO:0030054;GO:0016020;GO:0098589;GO:0044425;GO:0098590;GO:0044464;GO:0031224;GO:0046581;GO:0016021;GO:0031226;GO:0045177;GO:0044459;GO:0016324;GO:0009986;GO:0005911;GO:0005623;GO:0071944;GO:0098805;GO:0005887;GO:0005886;GO:0005575; cell junction;membrane;membrane region;membrane part;plasma membrane region;cell part;intrinsic component of membrane;intercellular canaliculus;integral component of membrane;intrinsic component of plasma membrane;apical part of cell;plasma membrane part;apical plasma membrane;cell surface;cell-cell junction;cell;cell periphery;whole membrane;integral component of plasma membrane;plasma membrane;cellular_component; 2;2;3;2;4;2;3;4;4;4;3;3;4;3;3;2;3;3;4;3;1; GO:1901363;GO:0008509;GO:0016818;GO:0097367;GO:0016817;GO:0005524;GO:0015405;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042626;GO:0042623;GO:0015399;GO:0032549;GO:0017076;GO:0022804;GO:0016787;GO:0003824;GO:0022891;GO:0022892;GO:0097159;GO:0015075;GO:0016462;GO:0032559;GO:0032555;GO:0032553;GO:0035639;GO:0000166;GO:0043168;GO:0016820;GO:0043167;GO:0005215;GO:0030554;GO:0043492;GO:0032550;GO:0001882;GO:0001883;GO:0017111;GO:0036094;GO:0008514;GO:0022857; heterocyclic compound binding;anion transmembrane transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;ATP binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;primary active transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;active transmembrane transporter activity;hydrolase activity;catalytic activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;organic cyclic compound binding;ion transmembrane transporter activity;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;anion binding;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ion binding;transporter activity;adenyl nucleotide binding;ATPase activity, coupled to movement of substances;purine ribonucleoside binding;nucleoside binding;purine nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;organic anion transmembrane transporter activity;transmembrane transporter activity; 3;6;5;3;4;6;6;1;2;8;4;6;9;5;5;5;4;3;2;4;3;3;5;6;6;5;4;5;4;4;5;3;2;6;10;6;4;5;7;3;7;3; K05666 map02010;map04976; ABC transporters;Bile secretion; IPR030247;IPR005292;IPR003593;IPR017871;IPR003439;IPR011527;IPR027417; Canalicular multispecific organic anion transporter 1;Multi drug resistance-associated protein;AAA+ ATPase domain;ABC transporter, conserved site;ABC transporter-like;ABC transporter type 1, transmembrane domain;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Hs4557481 3179.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q9NY74 Ewing's tumor-associated antigen 1 OS=Homo sapiens OX=9606 GN=ETAA1 PE=1 SV=2 - [ETAA1_HUMAN] 1.117 1.074 1.179 0.877 1.026 0.487 1.040037244 nan 0.854775828 nan 1.097765363 nan 0.474658869 nan GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; IPR029406; Ewing's tumour-associated antigen 1; nucleus Q14957 Glutamate receptor ionotropic, NMDA 2C OS=Homo sapiens OX=9606 GN=GRIN2C PE=1 SV=3 - [NMDE3_HUMAN] 0.988 1.05 0.935 1.077 1.271 0.66 0.940952381 nan 0.84736428 nan 0.89047619 nan 0.519276161 nan GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0032147;GO:0007165;GO:0007166;GO:0007167;GO:0030182;GO:1905114;GO:0023014;GO:0051716;GO:0010605;GO:0010604;GO:0042330;GO:0009966;GO:0009967;GO:0071840;GO:0000165;GO:0070848;GO:0007215;GO:0033058;GO:0044093;GO:0048518;GO:0048519;GO:0033036;GO:0038179;GO:0006935;GO:0060255;GO:0048468;GO:0045859;GO:0006952;GO:0042221;GO:0050776;GO:0007173;GO:0030163;GO:0043434;GO:0097485;GO:0010033;GO:0003008;GO:0042325;GO:0044700;GO:0042327;GO:0009605;GO:0044707;GO:0019538;GO:0042176;GO:0002376;GO:0098916;GO:0002768;GO:0010243;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0033674;GO:0060078;GO:0006928;GO:0007169;GO:0035556;GO:0071900;GO:0050789;GO:0044267;GO:1901575;GO:0009653;GO:0051347;GO:0000902;GO:0044260;GO:0043549;GO:0044344;GO:0016043;GO:0065007;GO:0044699;GO:0065009;GO:0065008;GO:0006810;GO:0061564;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0048011;GO:1902533;GO:1902531;GO:0044767;GO:0038093;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0048869;GO:0071774;GO:0009611;GO:0099536;GO:0099537;GO:0042391;GO:0016310;GO:0030154;GO:0023056;GO:0060079;GO:0043405;GO:0042177;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0007411;GO:0010647;GO:0010646;GO:0008543;GO:0007265;GO:0043085;GO:0043408;GO:0009719;GO:0051248;GO:0051234;GO:0071375;GO:0050885;GO:0010562;GO:0051246;GO:0051247;GO:0009057;GO:0032270;GO:0031399;GO:0032502;GO:1901700;GO:0008286;GO:0032501;GO:1901701;GO:0009987;GO:0032870;GO:0038095;GO:0007409;GO:0048010;GO:0048858;GO:0032268;GO:0071363;GO:0009725;GO:0043170;GO:0048731;GO:0045860;GO:1901698;GO:0000186;GO:1901699;GO:0030030;GO:0031325;GO:0031175;GO:0031323;GO:0050905;GO:0032869;GO:0032868;GO:0007275;GO:0002682;GO:0071417;GO:0032989;GO:0071704;GO:0071310;GO:0048812;GO:0050877;GO:0048666;GO:0048667;GO:0006468;GO:0045937;GO:0045087;GO:0006464;GO:0051174;GO:0000904;GO:0044763;GO:0007268;GO:0007267;GO:0007154;GO:0022008;GO:0007264;GO:0009056;GO:0051179;GO:0002764;GO:0040011;GO:0044238;GO:0048699;GO:0032990;GO:0007399;GO:0099565;GO:0048856;GO:0044237;GO:0071495;GO:0006796;GO:1901652;GO:1901653;GO:0006793;GO:0001932;GO:0001934;GO:0048522; protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;neuron differentiation;cell surface receptor signaling pathway involved in cell-cell signaling;signal transduction by protein phosphorylation;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;taxis;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;response to growth factor;glutamate receptor signaling pathway;directional locomotion;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;macromolecule localization;neurotrophin signaling pathway;chemotaxis;regulation of macromolecule metabolic process;cell development;regulation of protein kinase activity;defense response;response to chemical;regulation of immune response;epidermal growth factor receptor signaling pathway;protein catabolic process;response to peptide hormone;neuron projection guidance;response to organic substance;system process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;response to external stimulus;single-multicellular organism process;protein metabolic process;regulation of protein catabolic process;immune system process;anterograde trans-synaptic signaling;immune response-regulating cell surface receptor signaling pathway;response to organonitrogen compound;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of kinase activity;regulation of postsynaptic membrane potential;movement of cell or subcellular component;transmembrane receptor protein tyrosine kinase signaling pathway;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cell morphogenesis;cellular macromolecule metabolic process;regulation of kinase activity;cellular response to fibroblast growth factor stimulus;cellular component organization;biological regulation;single-organism process;regulation of molecular function;regulation of biological quality;transport;axon development;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;single-organism developmental process;Fc receptor signaling pathway;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;cellular developmental process;response to fibroblast growth factor;response to wounding;synaptic signaling;trans-synaptic signaling;regulation of membrane potential;phosphorylation;cell differentiation;positive regulation of signaling;excitatory postsynaptic potential;regulation of MAP kinase activity;negative regulation of protein catabolic process;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;axon guidance;positive regulation of cell communication;regulation of cell communication;fibroblast growth factor receptor signaling pathway;Ras protein signal transduction;positive regulation of catalytic activity;regulation of MAPK cascade;response to endogenous stimulus;negative regulation of protein metabolic process;establishment of localization;cellular response to peptide hormone stimulus;neuromuscular process controlling balance;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;macromolecule catabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;developmental process;response to oxygen-containing compound;insulin receptor signaling pathway;multicellular organismal process;cellular response to oxygen-containing compound;cellular process;cellular response to hormone stimulus;Fc-epsilon receptor signaling pathway;axonogenesis;vascular endothelial growth factor receptor signaling pathway;cell projection morphogenesis;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;response to hormone;macromolecule metabolic process;system development;positive regulation of protein kinase activity;response to nitrogen compound;activation of MAPKK activity;cellular response to nitrogen compound;cell projection organization;positive regulation of cellular metabolic process;neuron projection development;regulation of cellular metabolic process;neuromuscular process;cellular response to insulin stimulus;response to insulin;multicellular organism development;regulation of immune system process;cellular response to organonitrogen compound;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;neuron projection morphogenesis;neurological system process;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;positive regulation of phosphate metabolic process;innate immune response;cellular protein modification process;regulation of phosphorus metabolic process;cell morphogenesis involved in differentiation;single-organism cellular process;synaptic transmission;cell-cell signaling;cell communication;neurogenesis;small GTPase mediated signal transduction;catabolic process;localization;immune response-regulating signaling pathway;locomotion;primary metabolic process;generation of neurons;cell part morphogenesis;nervous system development;chemical synaptic transmission, postsynaptic;anatomical structure development;cellular metabolic process;cellular response to endogenous stimulus;phosphate-containing compound metabolic process;response to peptide;cellular response to peptide;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 4;6;4;3;3;3;9;4;5;6;6;5;4;3;4;4;3;4;4;2;5;5;6;3;4;2;2;3;6;4;4;4;7;4;3;4;9;5;5;5;4;3;7;3;7;3;3;4;5;2;7;6;4;4;4;3;3;7;5;4;7;5;8;2;5;4;3;6;5;4;6;5;3;2;2;3;3;4;6;4;3;3;6;5;5;1;2;3;7;5;5;3;7;2;6;3;5;4;4;4;5;6;4;6;5;3;6;7;5;2;8;4;3;6;4;4;6;7;5;6;3;5;3;6;6;5;5;5;5;5;6;2;4;8;2;5;2;5;8;7;8;5;5;6;4;4;4;8;4;7;5;4;4;5;4;5;7;6;4;3;5;4;3;5;6;4;5;6;7;6;4;6;5;5;3;8;4;4;6;6;3;2;5;2;3;7;5;5;6;3;3;4;5;5;6;4;7;7;3; GO:0098802;GO:0097060;GO:0016020;GO:0098797;GO:0043234;GO:0043235;GO:0060076;GO:0098805;GO:0030054;GO:0044424;GO:0044425;GO:0098590;GO:0043232;GO:0043229;GO:0043228;GO:0031226;GO:0005886;GO:1990351;GO:0031224;GO:0044456;GO:0044459;GO:0016021;GO:0017146;GO:1902495;GO:0045211;GO:0014069;GO:0005622;GO:0044464;GO:0005623;GO:0034702;GO:0045202;GO:0099572;GO:0071944;GO:0005575;GO:0098589;GO:0008328;GO:0005887;GO:0032991;GO:0098796;GO:0098794;GO:0043226; plasma membrane receptor complex;synaptic membrane;membrane;plasma membrane protein complex;protein complex;receptor complex;excitatory synapse;whole membrane;cell junction;intracellular part;membrane part;plasma membrane region;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;intrinsic component of plasma membrane;plasma membrane;transporter complex;intrinsic component of membrane;synapse part;plasma membrane part;integral component of membrane;NMDA selective glutamate receptor complex;transmembrane transporter complex;postsynaptic membrane;postsynaptic density;intracellular;cell part;cell;ion channel complex;synapse;postsynaptic specialization;cell periphery;cellular_component;membrane region;ionotropic glutamate receptor complex;integral component of plasma membrane;macromolecular complex;membrane protein complex;postsynapse;organelle; 4;3;2;4;3;4;3;3;2;3;2;4;4;3;3;4;3;4;3;2;3;4;6;4;4;4;3;2;2;5;2;3;3;1;3;5;4;2;3;3;2; GO:0060089;GO:0008066;GO:0005261;GO:0022838;GO:0030594;GO:0099600;GO:0003674;GO:0022803;GO:0005231;GO:0005230;GO:0005234;GO:0022891;GO:0022892;GO:0015075;GO:0015267;GO:0015276;GO:0022824;GO:0005215;GO:0005216;GO:0022836;GO:0022835;GO:0022834;GO:0038023;GO:0004888;GO:0004872;GO:0004871;GO:0004972;GO:0004970;GO:0022857;GO:0008324; molecular transducer activity;glutamate receptor activity;cation channel activity;substrate-specific channel activity;neurotransmitter receptor activity;transmembrane receptor activity;molecular_function;passive transmembrane transporter activity;excitatory extracellular ligand-gated ion channel activity;extracellular ligand-gated ion channel activity;extracellular-glutamate-gated ion channel activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;channel activity;ligand-gated ion channel activity;transmitter-gated ion channel activity;transporter activity;ion channel activity;gated channel activity;transmitter-gated channel activity;ligand-gated channel activity;signaling receptor activity;transmembrane signaling receptor activity;receptor activity;signal transducer activity;NMDA glutamate receptor activity;ionotropic glutamate receptor activity;transmembrane transporter activity;cation transmembrane transporter activity; 2;5;7;5;4;4;1;4;8;7;9;4;3;5;5;6;6;2;6;6;5;5;3;4;3;2;7;6;3;6; K05211 map04020;map04024;map04080;map04713;map04720;map04724;map05010;map05014;map05030;map05031;map05033;map05034; Calcium signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;Circadian entrainment;Long-term potentiation;Glutamatergic synapse;Alzheimer's disease;Amyotrophic lateral sclerosis (ALS);Cocaine addiction;Amphetamine addiction;Nicotine addiction;Alcoholism; IPR028082;IPR001320;IPR001508;IPR001828;IPR019594;IPR018884; Periplasmic binding protein-like I;Ionotropic glutamate receptor;Ionotropic glutamate receptor, metazoa;Receptor, ligand binding region;Ionotropic glutamate receptor, L-glutamate and glycine-binding domain;Glutamate [NMDA] receptor, epsilon subunit, C-terminal; plasma membrane Hs4504129 2514.0 PET [P] Inorganic ion transport and metabolism;[E] Amino acid transport and metabolism;[T] Signal transduction mechanisms; Q9BXM9 FSD1-like protein OS=Homo sapiens OX=9606 GN=FSD1L PE=1 SV=2 - [FSD1L_HUMAN] 0.687 0.644 2.158 0.679 0.723 1.03 1.066770186 nan 0.939142462 nan 3.350931677 nan 1.42461964 nan IPR013783;IPR003879;IPR003877;IPR003649;IPR013320;IPR001870;IPR003961;IPR017903; Immunoglobulin-like fold;Butyrophylin-like, SPRY domain;SPRY domain;B-box, C-terminal;Concanavalin A-like lectin/glucanase domain;B30.2/SPRY domain;Fibronectin type III;COS domain; cytosol Hs13236585 637.0 O [O] Posttranslational modification, protein turnover, chaperones; Q15361 Transcription termination factor 1 OS=Homo sapiens OX=9606 GN=TTF1 PE=1 SV=3 - [TTF1_HUMAN] 0.86 0.942 1.121 0.773 1.144 2.017 0.912951168 nan 0.675699301 nan 1.190021231 nan 1.763111888 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0040029;GO:0006260;GO:0048519;GO:0051053;GO:0051052;GO:0060255;GO:2001141;GO:0046483;GO:0019538;GO:0006275;GO:0019438;GO:0009892;GO:0009890;GO:0097659;GO:0044267;GO:0044260;GO:0016043;GO:0006361;GO:0006360;GO:0006363;GO:0065007;GO:0071840;GO:0018130;GO:0009889;GO:0050794;GO:0008156;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0006352;GO:0006353;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0031327;GO:0009987;GO:0006725;GO:1903506;GO:0006338;GO:0051252;GO:0010629;GO:0043170;GO:0006807;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0006325;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0045814;GO:0010468;GO:0045934;GO:1901576;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0016568;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0006259;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;regulation of gene expression, epigenetic;DNA replication;negative regulation of biological process;negative regulation of DNA metabolic process;regulation of DNA metabolic process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;protein metabolic process;regulation of DNA replication;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nucleic acid-templated transcription;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;transcription initiation from RNA polymerase I promoter;transcription from RNA polymerase I promoter;termination of RNA polymerase I transcription;biological regulation;cellular component organization or biogenesis;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;negative regulation of DNA replication;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;DNA-templated transcription, termination;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;negative regulation of cellular biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;chromatin remodeling;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;nitrogen compound metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;negative regulation of gene expression, epigenetic;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;chromatin modification;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;DNA metabolic process;negative regulation of cellular process; 4;3;5;4;4;6;6;2;5;5;4;6;4;4;6;5;3;4;7;5;4;3;8;7;8;2;2;5;4;3;6;1;2;5;5;5;6;5;6;7;7;5;6;4;4;5;4;5;2;4;7;7;5;5;4;3;4;5;4;4;5;5;6;6;2;3;5;6;5;5;4;5;3;5;4;4;6;4;3;5;3;5;3; GO:0031974;GO:0005654;GO:0031981;GO:0016020;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0071944;GO:0005886;GO:0005575;GO:0070013; membrane-enclosed lumen;nucleoplasm;nuclear lumen;membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasm;nucleolus;nucleus;cell part;cell;cell periphery;plasma membrane;cellular_component;intracellular organelle lumen; 2;5;5;2;4;4;3;4;3;2;3;3;3;3;2;3;4;5;5;2;2;3;3;1;4; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0044877;GO:0003682; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;macromolecular complex binding;chromatin binding; 3;1;2;4;5;3;3;4; K15225 map04918; Thyroid hormone synthesis; IPR001005;IPR017877; SANT/Myb domain;Myb-like domain; nucleus Hs6678455 1796.0 K [K] Transcription; Q96QB1 Rho GTPase-activating protein 7 OS=Homo sapiens OX=9606 GN=DLC1 PE=1 SV=4 - [RHG07_HUMAN] 0.992 1.138 0.77 1.088 1.267 1.024 0.871704745 nan 0.858721389 nan 0.676625659 nan 0.808208366 nan GO:0044238;GO:0019220;GO:0080090;GO:0019222;GO:0006470;GO:0048585;GO:0048583;GO:0007160;GO:0007266;GO:0072358;GO:0007165;GO:0051893;GO:0071840;GO:0032231;GO:0051716;GO:0032879;GO:0010604;GO:0009968;GO:0009966;GO:0048869;GO:0051493;GO:0051492;GO:0048513;GO:0044093;GO:0014020;GO:0048518;GO:0048519;GO:0040011;GO:0042127;GO:0051056;GO:0031589;GO:1901889;GO:1901888;GO:0060255;GO:0021575;GO:0051058;GO:0003007;GO:0007507;GO:0030162;GO:0035148;GO:0001843;GO:0010467;GO:0044700;GO:0065008;GO:0044707;GO:0019538;GO:0048870;GO:0007162;GO:0009792;GO:0022604;GO:0022607;GO:0009893;GO:0022603;GO:0001953;GO:0023051;GO:0009887;GO:0010639;GO:0051674;GO:1903391;GO:1903392;GO:0035556;GO:0050789;GO:0060322;GO:0044267;GO:0001838;GO:0009653;GO:0043547;GO:0051345;GO:0010950;GO:0006919;GO:0016043;GO:0090109;GO:0052548;GO:1900119;GO:0065007;GO:0001841;GO:0065009;GO:0016477;GO:1900117;GO:0048646;GO:0043149;GO:0043085;GO:0050790;GO:2001056;GO:0050793;GO:0032232;GO:0050794;GO:0060606;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0032956;GO:1902532;GO:0035303;GO:1902531;GO:0035304;GO:0035307;GO:0035306;GO:0051336;GO:0051174;GO:0007420;GO:0051604;GO:0050896;GO:0031401;GO:0051497;GO:2000145;GO:2000146;GO:0007275;GO:0010562;GO:0072359;GO:0051494;GO:0061572;GO:0033043;GO:0016311;GO:0030155;GO:0046578;GO:0051129;GO:0051128;GO:0035024;GO:0023057;GO:0007045;GO:0007044;GO:0023052;GO:0010648;GO:0035023;GO:0010646;GO:0043087;GO:0035295;GO:0044699;GO:0007417;GO:0010952;GO:0051246;GO:0051247;GO:0043933;GO:0032270;GO:0031399;GO:0060562;GO:0043009;GO:0022610;GO:0031325;GO:0032502;GO:0008285;GO:0097194;GO:0032501;GO:0035239;GO:0008360;GO:0008283;GO:0031323;GO:0009987;GO:0051017;GO:0040013;GO:0043281;GO:0040012;GO:0045216;GO:0043280;GO:0016485;GO:0006928;GO:0034329;GO:0032268;GO:0001952;GO:0048731;GO:0009790;GO:0030038;GO:0016331;GO:0048856;GO:0031032;GO:0034333;GO:0034332;GO:0060429;GO:0034330;GO:0030036;GO:0006796;GO:0043170;GO:0072175;GO:0048041;GO:0010942;GO:0008219;GO:0010941;GO:0002009;GO:0009888;GO:0071822;GO:0006508;GO:2000116;GO:0042981;GO:0031638;GO:0043065;GO:0071704;GO:0043067;GO:0048729;GO:0045937;GO:0043068;GO:0048598;GO:0030336;GO:0032970;GO:0021915;GO:0030029;GO:0052547;GO:0010810;GO:0010812;GO:0006915;GO:0097202;GO:0030334;GO:0044767;GO:0045862;GO:0044763;GO:0046580;GO:0007155;GO:0007154;GO:0007265;GO:0007264;GO:0051179;GO:0000902;GO:0006996;GO:0007015;GO:0051271;GO:0051270;GO:0007010;GO:0044260;GO:0007399;GO:0044237;GO:0044087;GO:1902589;GO:0044085;GO:0030900;GO:0032989;GO:0030902;GO:0006793;GO:0051895;GO:0048523;GO:0048522; primary metabolic process;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;negative regulation of response to stimulus;regulation of response to stimulus;cell-matrix adhesion;Rho protein signal transduction;cardiovascular system development;signal transduction;regulation of focal adhesion assembly;cellular component organization or biogenesis;regulation of actin filament bundle assembly;cellular response to stimulus;regulation of localization;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;regulation of cytoskeleton organization;regulation of stress fiber assembly;animal organ development;positive regulation of molecular function;primary neural tube formation;positive regulation of biological process;negative regulation of biological process;locomotion;regulation of cell proliferation;regulation of small GTPase mediated signal transduction;cell-substrate adhesion;negative regulation of cell junction assembly;regulation of cell junction assembly;regulation of macromolecule metabolic process;hindbrain morphogenesis;negative regulation of small GTPase mediated signal transduction;heart morphogenesis;heart development;regulation of proteolysis;tube formation;neural tube closure;gene expression;single organism signaling;regulation of biological quality;single-multicellular organism process;protein metabolic process;cell motility;negative regulation of cell adhesion;embryo development ending in birth or egg hatching;regulation of cell morphogenesis;cellular component assembly;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;negative regulation of cell-matrix adhesion;regulation of signaling;organ morphogenesis;negative regulation of organelle organization;localization of cell;regulation of adherens junction organization;negative regulation of adherens junction organization;intracellular signal transduction;regulation of biological process;head development;cellular protein metabolic process;embryonic epithelial tube formation;anatomical structure morphogenesis;positive regulation of GTPase activity;positive regulation of hydrolase activity;positive regulation of endopeptidase activity;activation of cysteine-type endopeptidase activity involved in apoptotic process;cellular component organization;regulation of cell-substrate junction assembly;regulation of endopeptidase activity;positive regulation of execution phase of apoptosis;biological regulation;neural tube formation;regulation of molecular function;cell migration;regulation of execution phase of apoptosis;anatomical structure formation involved in morphogenesis;stress fiber assembly;positive regulation of catalytic activity;regulation of catalytic activity;positive regulation of cysteine-type endopeptidase activity;regulation of developmental process;negative regulation of actin filament bundle assembly;regulation of cellular process;tube closure;programmed cell death;macromolecule modification;protein modification process;biological_process;cellular protein modification process;metabolic process;regulation of actin cytoskeleton organization;negative regulation of intracellular signal transduction;regulation of dephosphorylation;regulation of intracellular signal transduction;regulation of protein dephosphorylation;positive regulation of protein dephosphorylation;positive regulation of dephosphorylation;regulation of hydrolase activity;regulation of phosphorus metabolic process;brain development;protein maturation;response to stimulus;positive regulation of protein modification process;negative regulation of stress fiber assembly;regulation of cell motility;negative regulation of cell motility;multicellular organism development;positive regulation of phosphorus metabolic process;circulatory system development;negative regulation of cytoskeleton organization;actin filament bundle organization;regulation of organelle organization;dephosphorylation;regulation of cell adhesion;regulation of Ras protein signal transduction;negative regulation of cellular component organization;regulation of cellular component organization;negative regulation of Rho protein signal transduction;negative regulation of signaling;cell-substrate adherens junction assembly;cell-substrate junction assembly;signaling;negative regulation of cell communication;regulation of Rho protein signal transduction;regulation of cell communication;regulation of GTPase activity;tube development;single-organism process;central nervous system development;positive regulation of peptidase activity;regulation of protein metabolic process;positive regulation of protein metabolic process;macromolecular complex subunit organization;positive regulation of cellular protein metabolic process;regulation of protein modification process;epithelial tube morphogenesis;chordate embryonic development;biological adhesion;positive regulation of cellular metabolic process;developmental process;negative regulation of cell proliferation;execution phase of apoptosis;multicellular organismal process;tube morphogenesis;regulation of cell shape;cell proliferation;regulation of cellular metabolic process;cellular process;actin filament bundle assembly;negative regulation of locomotion;regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of locomotion;cell-cell junction organization;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;protein processing;movement of cell or subcellular component;cell junction assembly;regulation of cellular protein metabolic process;regulation of cell-matrix adhesion;system development;embryo development;contractile actin filament bundle assembly;morphogenesis of embryonic epithelium;anatomical structure development;actomyosin structure organization;adherens junction assembly;adherens junction organization;epithelium development;cell junction organization;actin cytoskeleton organization;phosphate-containing compound metabolic process;macromolecule metabolic process;epithelial tube formation;focal adhesion assembly;positive regulation of cell death;cell death;regulation of cell death;morphogenesis of an epithelium;tissue development;protein complex subunit organization;proteolysis;regulation of cysteine-type endopeptidase activity;regulation of apoptotic process;zymogen activation;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;tissue morphogenesis;positive regulation of phosphate metabolic process;positive regulation of programmed cell death;embryonic morphogenesis;negative regulation of cell migration;regulation of actin filament-based process;neural tube development;actin filament-based process;regulation of peptidase activity;regulation of cell-substrate adhesion;negative regulation of cell-substrate adhesion;apoptotic process;activation of cysteine-type endopeptidase activity;regulation of cell migration;single-organism developmental process;positive regulation of proteolysis;single-organism cellular process;negative regulation of Ras protein signal transduction;cell adhesion;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;localization;cell morphogenesis;organelle organization;actin filament organization;negative regulation of cellular component movement;regulation of cellular component movement;cytoskeleton organization;cellular macromolecule metabolic process;nervous system development;cellular metabolic process;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;forebrain development;cellular component morphogenesis;hindbrain development;phosphorus metabolic process;negative regulation of focal adhesion assembly;negative regulation of cellular process;positive regulation of cellular process; 3;6;4;3;7;3;3;5;8;5;4;6;2;4;3;3;4;4;4;4;6;5;4;4;6;2;2;2;4;6;4;5;4;4;4;6;5;4;6;4;6;5;3;3;3;4;3;4;6;5;4;3;4;6;3;4;5;3;5;5;5;2;4;5;6;3;7;6;8;7;3;5;7;5;2;5;3;4;5;3;7;5;4;9;3;5;3;5;5;5;5;1;6;2;5;5;7;5;7;7;7;5;5;4;5;2;6;6;4;4;4;5;5;6;7;5;6;4;7;4;4;8;3;7;6;2;4;8;4;6;4;2;5;7;5;5;4;5;6;5;7;2;4;2;4;4;2;4;4;3;4;2;5;3;7;3;5;7;6;4;5;5;6;4;5;6;5;3;6;6;6;5;4;5;5;4;5;6;4;4;4;5;4;5;5;8;6;7;6;3;5;4;6;5;4;5;4;4;4;6;5;5;6;8;5;3;6;3;7;3;4;7;6;2;5;4;6;4;4;5;4;5;3;3;4;3;4;4;4;4;6;3;3; GO:0044853;GO:0030055;GO:0016020;GO:0032587;GO:0001726;GO:0098589;GO:0043231;GO:0005901;GO:0005829;GO:0005856;GO:0044424;GO:0044425;GO:0098857;GO:0099568;GO:0098590;GO:0042995;GO:0043229;GO:0005925;GO:0043227;GO:0030054;GO:0031256;GO:0070161;GO:0031253;GO:0030863;GO:0030864;GO:0044446;GO:0044444;GO:0044422;GO:0044448;GO:0005938;GO:0005737;GO:0005634;GO:0044459;GO:0015629;GO:0005912;GO:0031252;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0071944;GO:0043232;GO:0005924;GO:0098805;GO:0043226;GO:0044430;GO:0005886;GO:0045121;GO:0005575; plasma membrane raft;cell-substrate junction;membrane;ruffle membrane;ruffle;membrane region;intracellular membrane-bounded organelle;caveola;cytosol;cytoskeleton;intracellular part;membrane part;membrane microdomain;cytoplasmic region;plasma membrane region;cell projection;intracellular organelle;focal adhesion;membrane-bounded organelle;cell junction;leading edge membrane;anchoring junction;cell projection membrane;cortical cytoskeleton;cortical actin cytoskeleton;intracellular organelle part;cytoplasmic part;organelle part;cell cortex part;cell cortex;cytoplasm;nucleus;plasma membrane part;actin cytoskeleton;adherens junction;cell leading edge;cell projection part;cell part;cell;intracellular;non-membrane-bounded organelle;cell periphery;intracellular non-membrane-bounded organelle;cell-substrate adherens junction;whole membrane;organelle;cytoskeletal part;plasma membrane;membrane raft;cellular_component; 4;3;2;5;4;3;4;5;5;5;3;2;4;5;4;3;3;5;3;2;4;3;4;6;5;3;4;2;5;4;4;5;3;6;4;3;3;2;2;3;3;3;4;4;3;2;4;3;5;1; GO:0098772;GO:0005096;GO:0030695;GO:0019904;GO:0005488;GO:0030234;GO:0060589;GO:0005515;GO:0003674;GO:0042169;GO:0008047;GO:0008289; molecular function regulator;GTPase activator activity;GTPase regulator activity;protein domain specific binding;binding;enzyme regulator activity;nucleoside-triphosphatase regulator activity;protein binding;molecular_function;SH2 domain binding;enzyme activator activity;lipid binding; 2;5;5;4;2;3;4;3;1;5;4;3; K20632 IPR002913;IPR013761;IPR000198;IPR028854;IPR008936;IPR023393;IPR001660; START domain;Sterile alpha motif/pointed domain;Rho GTPase-activating protein domain;Rho GTPase-activating protein 7;Rho GTPase activation protein;START-like domain;Sterile alpha motif domain; nucleus Hs5174427 2230.0 T [T] Signal transduction mechanisms; O76003 Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2 - [GLRX3_HUMAN] 1.452 1.088 0.848 0.979 0.956 0.526 1.334558824 nan 1.024058577 nan 0.779411765 nan 0.550209205 nan GO:0048583;GO:0003012;GO:0003013;GO:0003015;GO:0048519;GO:0019725;GO:0003008;GO:0044707;GO:0014741;GO:0014743;GO:0050789;GO:0065007;GO:0065008;GO:0008015;GO:0008016;GO:0050794;GO:0008150;GO:0051239;GO:0014897;GO:1903522;GO:0060047;GO:0044699;GO:0044057;GO:0051241;GO:0003300;GO:0002026;GO:0032501;GO:0009987;GO:0045454;GO:0050896;GO:0042592;GO:0043502;GO:0043500;GO:0014896;GO:0044763;GO:0090257;GO:0010611;GO:0010614; regulation of response to stimulus;muscle system process;circulatory system process;heart process;negative regulation of biological process;cellular homeostasis;system process;single-multicellular organism process;negative regulation of muscle hypertrophy;regulation of muscle hypertrophy;regulation of biological process;biological regulation;regulation of biological quality;blood circulation;regulation of heart contraction;regulation of cellular process;biological_process;regulation of multicellular organismal process;striated muscle hypertrophy;regulation of blood circulation;heart contraction;single-organism process;regulation of system process;negative regulation of multicellular organismal process;cardiac muscle hypertrophy;regulation of the force of heart contraction;multicellular organismal process;cellular process;cell redox homeostasis;response to stimulus;homeostatic process;regulation of muscle adaptation;muscle adaptation;muscle hypertrophy;single-organism cellular process;regulation of muscle system process;regulation of cardiac muscle hypertrophy;negative regulation of cardiac muscle hypertrophy; 3;4;4;5;2;4;3;3;4;6;2;2;3;5;6;3;1;3;6;5;6;2;4;3;7;4;2;2;4;2;4;4;3;5;3;5;5;5; GO:0030425;GO:0031982;GO:0036477;GO:0042995;GO:0043230;GO:0043232;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0031674;GO:0030018;GO:0005938;GO:0044444;GO:0044449;GO:0030016;GO:0030017;GO:0005737;GO:0005634;GO:0043005;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0043226;GO:0097458;GO:0099568;GO:1903561;GO:0005575;GO:0005576;GO:0043292; dendrite;vesicle;somatodendritic compartment;cell projection;extracellular organelle;intracellular non-membrane-bounded organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;I band;Z disc;cell cortex;cytoplasmic part;contractile fiber part;myofibril;sarcomere;cytoplasm;nucleus;neuron projection;cell part;cell;intracellular;cell periphery;extracellular exosome;organelle;neuron part;cytoplasmic region;extracellular vesicle;cellular_component;extracellular region;contractile fiber; 5;4;4;3;3;4;4;3;2;2;3;3;3;4;4;4;4;3;6;4;4;5;4;2;2;3;3;4;2;3;5;3;1;2;5; GO:1901363;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:0003824;GO:0097159;GO:0051536;GO:0016491;GO:0043169;GO:0043167;GO:0009055;GO:0016667;GO:0044822;GO:0003723;GO:0051540;GO:0015035;GO:0015036; heterocyclic compound binding;metal ion binding;molecular_function;binding;nucleic acid binding;catalytic activity;organic cyclic compound binding;iron-sulfur cluster binding;oxidoreductase activity;cation binding;ion binding;electron carrier activity;oxidoreductase activity, acting on a sulfur group of donors;poly(A) RNA binding;RNA binding;metal cluster binding;protein disulfide oxidoreductase activity;disulfide oxidoreductase activity; 3;5;1;2;4;2;3;4;3;4;3;2;4;6;5;3;6;5; IPR002109;IPR033658;IPR004480;IPR013766;IPR012336; Glutaredoxin;Glutaredoxin, PICOT-like;Monothiol glutaredoxin-related;Thioredoxin domain;Thioredoxin-like fold; cytosol Hs5730104 683.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9Y5P4 Collagen type IV alpha-3-binding protein OS=Homo sapiens OX=9606 GN=COL4A3BP PE=1 SV=1 - [C43BP_HUMAN] 0.823 1.189 1.188 0.749 1.316 0.517 0.692178301 nan 0.569148936 nan 0.999158957 nan 0.392857143 nan GO:0003012;GO:0072358;GO:0007165;GO:0032989;GO:0071840;GO:0051716;GO:0044711;GO:0048869;GO:0010256;GO:0048513;GO:0033036;GO:0006665;GO:0006936;GO:0071702;GO:0003007;GO:0010876;GO:0003008;GO:0070584;GO:0044700;GO:1901564;GO:0044707;GO:0019538;GO:0072359;GO:0048878;GO:0002376;GO:0033554;GO:0006672;GO:0044281;GO:0006950;GO:0009887;GO:0006807;GO:0043170;GO:0050789;GO:0035627;GO:0044267;GO:0000902;GO:0044260;GO:0016043;GO:0065007;GO:0007005;GO:0065008;GO:0030148;GO:0035621;GO:0006629;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0046907;GO:0050896;GO:0032365;GO:0044765;GO:0006869;GO:0016310;GO:0006955;GO:0034641;GO:0009792;GO:0023052;GO:0009653;GO:1901566;GO:0044699;GO:0042886;GO:0001701;GO:0006810;GO:0046467;GO:0043009;GO:0051641;GO:0032502;GO:0032501;GO:0006643;GO:0008283;GO:0009987;GO:0055088;GO:0044255;GO:0043603;GO:0048731;GO:0009790;GO:0034976;GO:0007507;GO:0042592;GO:0007275;GO:0007029;GO:1902589;GO:0071705;GO:0071704;GO:0006468;GO:1901576;GO:0006464;GO:0044767;GO:0009058;GO:0044763;GO:0051649;GO:0007154;GO:0051179;GO:1902578;GO:0008610;GO:0006996;GO:0044238;GO:0032990;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:1902582;GO:0044249; muscle system process;cardiovascular system development;signal transduction;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;single-organism biosynthetic process;cellular developmental process;endomembrane system organization;animal organ development;macromolecule localization;sphingolipid metabolic process;muscle contraction;organic substance transport;heart morphogenesis;lipid localization;system process;mitochondrion morphogenesis;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;circulatory system development;chemical homeostasis;immune system process;cellular response to stress;ceramide metabolic process;small molecule metabolic process;response to stress;organ morphogenesis;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;ceramide transport;cellular protein metabolic process;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;biological regulation;mitochondrion organization;regulation of biological quality;sphingolipid biosynthetic process;ER to Golgi ceramide transport;lipid metabolic process;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;intracellular transport;response to stimulus;intracellular lipid transport;single-organism transport;lipid transport;phosphorylation;immune response;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;anatomical structure morphogenesis;organonitrogen compound biosynthetic process;single-organism process;amide transport;in utero embryonic development;transport;membrane lipid biosynthetic process;chordate embryonic development;cellular localization;developmental process;multicellular organismal process;membrane lipid metabolic process;cell proliferation;cellular process;lipid homeostasis;cellular lipid metabolic process;cellular amide metabolic process;system development;embryo development;response to endoplasmic reticulum stress;heart development;homeostatic process;multicellular organism development;endoplasmic reticulum organization;single-organism organelle organization;nitrogen compound transport;organic substance metabolic process;protein phosphorylation;organic substance biosynthetic process;cellular protein modification process;single-organism developmental process;biosynthetic process;single-organism cellular process;establishment of localization in cell;cell communication;localization;single-organism localization;lipid biosynthetic process;organelle organization;primary metabolic process;cell part morphogenesis;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;single-organism intracellular transport;cellular biosynthetic process; 4;5;4;4;2;3;4;4;4;4;3;5;5;5;5;4;3;5;3;4;3;4;5;5;2;4;6;4;3;4;3;4;2;6;5;5;4;3;2;5;3;6;7;4;3;3;5;5;1;2;3;5;2;6;4;5;6;3;4;6;2;3;5;2;5;8;4;5;7;3;2;2;5;3;2;6;4;5;4;5;5;4;4;4;5;4;5;3;7;4;6;3;3;3;4;4;2;3;5;4;3;5;3;3;5;4;5;4; GO:0005783;GO:0031974;GO:0005789;GO:0031981;GO:0016020;GO:0005794;GO:0098588;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044432;GO:0005737;GO:0012505;GO:0044446;GO:0044444;GO:0042175;GO:0031090;GO:0005634;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; endoplasmic reticulum;membrane-enclosed lumen;endoplasmic reticulum membrane;nuclear lumen;membrane;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;endoplasmic reticulum part;cytoplasm;endomembrane system;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;organelle membrane;nucleus;mitochondrion;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 4;2;3;5;2;4;4;4;3;5;4;3;2;2;3;3;5;4;4;3;3;4;3;3;5;5;2;2;3;2;1;4; GO:0016740;GO:0005319;GO:0003674;GO:0005488;GO:0097001;GO:0035620;GO:0016301;GO:0003824;GO:1901981;GO:0022892;GO:0035091;GO:0016772;GO:0005543;GO:0070273;GO:0043168;GO:0043167;GO:0033218;GO:0008289;GO:0016773;GO:0005215;GO:0004672;GO:0046624;GO:0046625; transferase activity;lipid transporter activity;molecular_function;binding;ceramide binding;ceramide transporter activity;kinase activity;catalytic activity;phosphatidylinositol phosphate binding;substrate-specific transporter activity;phosphatidylinositol binding;transferase activity, transferring phosphorus-containing groups;phospholipid binding;phosphatidylinositol-4-phosphate binding;anion binding;ion binding;amide binding;lipid binding;phosphotransferase activity, alcohol group as acceptor;transporter activity;protein kinase activity;sphingolipid transporter activity;sphingolipid binding; 3;4;1;2;4;6;5;2;6;3;5;4;4;7;4;3;3;3;5;2;6;5;4; K08283 IPR002913;IPR023393;IPR001849;IPR011993; START domain;START-like domain;Pleckstrin homology domain;PH domain-like; nucleus Hs5031717 1306.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; P01042 Kininogen-1 OS=Homo sapiens OX=9606 GN=KNG1 PE=1 SV=2 - [KNG1_HUMAN] 1.031 1.007 0.966 1.045 1.011 0.995 1.023833168 0.565862241 1.033630069 2.08E-05 0.959285005 0.194549857 0.984174085 2.57E-10 GO:0007599;GO:0080090;GO:0051046;GO:0051047;GO:0051049;GO:0007597;GO:0007596;GO:0048583;GO:0032846;GO:0032844;GO:0007162;GO:0003013;GO:0003014;GO:0003018;GO:0055078;GO:0045055;GO:0044710;GO:0009611;GO:0042981;GO:0010466;GO:0044092;GO:0048518;GO:0048519;GO:0050801;GO:0019725;GO:0051050;GO:0060255;GO:0006939;GO:0030162;GO:0030168;GO:0003008;GO:0044707;GO:0019538;GO:0003012;GO:0048878;GO:0055074;GO:0009892;GO:0006936;GO:0007204;GO:0098771;GO:0042311;GO:0043170;GO:0009605;GO:0044267;GO:0051346;GO:0006887;GO:0090066;GO:1900046;GO:1900047;GO:0065007;GO:0065009;GO:0065008;GO:0035150;GO:0050790;GO:0072507;GO:0008015;GO:0006810;GO:0042060;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0010605;GO:0051234;GO:0050818;GO:0051336;GO:0046903;GO:0044057;GO:0050896;GO:0001775;GO:0030195;GO:0006954;GO:0032102;GO:0051239;GO:0032101;GO:0030193;GO:0030155;GO:0010951;GO:0048585;GO:0043086;GO:0044699;GO:0051248;GO:0050880;GO:0072503;GO:0051240;GO:0051241;GO:0051246;GO:0006508;GO:0022610;GO:1903034;GO:1903035;GO:0032501;GO:0050878;GO:0006875;GO:0006874;GO:0009987;GO:0006873;GO:0030003;GO:0055080;GO:0055082;GO:0032879;GO:0032269;GO:0032268;GO:0044062;GO:0032940;GO:0035809;GO:0045861;GO:0080134;GO:0031324;GO:0031323;GO:0042592;GO:0061041;GO:0061045;GO:0010942;GO:0008219;GO:0010941;GO:0072376;GO:0072378;GO:0002576;GO:0098801;GO:0050789;GO:0043065;GO:0071704;GO:0043067;GO:2000021;GO:0035810;GO:0035813;GO:0035812;GO:0035815;GO:0043068;GO:0007588;GO:0052547;GO:0052548;GO:0006915;GO:0044765;GO:0044763;GO:0055067;GO:0055065;GO:0007155;GO:0019222;GO:0051179;GO:1902578;GO:0044238;GO:0044260;GO:0051480;GO:0044237;GO:0050819;GO:0048522;GO:0048523;GO:0016192; hemostasis;regulation of primary metabolic process;regulation of secretion;positive regulation of secretion;regulation of transport;blood coagulation, intrinsic pathway;blood coagulation;regulation of response to stimulus;positive regulation of homeostatic process;regulation of homeostatic process;negative regulation of cell adhesion;circulatory system process;renal system process;vascular process in circulatory system;sodium ion homeostasis;regulated exocytosis;single-organism metabolic process;response to wounding;regulation of apoptotic process;negative regulation of peptidase activity;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;ion homeostasis;cellular homeostasis;positive regulation of transport;regulation of macromolecule metabolic process;smooth muscle contraction;regulation of proteolysis;platelet activation;system process;single-multicellular organism process;protein metabolic process;muscle system process;chemical homeostasis;calcium ion homeostasis;negative regulation of metabolic process;muscle contraction;positive regulation of cytosolic calcium ion concentration;inorganic ion homeostasis;vasodilation;macromolecule metabolic process;response to external stimulus;cellular protein metabolic process;negative regulation of hydrolase activity;exocytosis;regulation of anatomical structure size;regulation of hemostasis;negative regulation of hemostasis;biological regulation;regulation of molecular function;regulation of biological quality;regulation of tube size;regulation of catalytic activity;divalent inorganic cation homeostasis;blood circulation;transport;wound healing;regulation of cellular process;defense response;programmed cell death;response to stress;coagulation;biological_process;metabolic process;negative regulation of macromolecule metabolic process;establishment of localization;regulation of coagulation;regulation of hydrolase activity;secretion;regulation of system process;response to stimulus;cell activation;negative regulation of blood coagulation;inflammatory response;negative regulation of response to external stimulus;regulation of multicellular organismal process;regulation of response to external stimulus;regulation of blood coagulation;regulation of cell adhesion;negative regulation of endopeptidase activity;negative regulation of response to stimulus;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of blood vessel size;cellular divalent inorganic cation homeostasis;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;proteolysis;biological adhesion;regulation of response to wounding;negative regulation of response to wounding;multicellular organismal process;regulation of body fluid levels;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular process;cellular ion homeostasis;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of localization;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of excretion;secretion by cell;regulation of urine volume;negative regulation of proteolysis;regulation of response to stress;negative regulation of cellular metabolic process;regulation of cellular metabolic process;homeostatic process;regulation of wound healing;negative regulation of wound healing;positive regulation of cell death;cell death;regulation of cell death;protein activation cascade;blood coagulation, fibrin clot formation;platelet degranulation;regulation of renal system process;regulation of biological process;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;regulation of ion homeostasis;positive regulation of urine volume;regulation of renal sodium excretion;renal sodium excretion;positive regulation of renal sodium excretion;positive regulation of programmed cell death;excretion;regulation of peptidase activity;regulation of endopeptidase activity;apoptotic process;single-organism transport;single-organism cellular process;monovalent inorganic cation homeostasis;metal ion homeostasis;cell adhesion;regulation of metabolic process;localization;single-organism localization;primary metabolic process;cellular macromolecule metabolic process;regulation of cytosolic calcium ion concentration;cellular metabolic process;negative regulation of coagulation;positive regulation of cellular process;negative regulation of cellular process;vesicle-mediated transport; 5;4;5;4;4;4;5;3;3;3;4;4;4;5;9;6;3;4;6;7;4;2;2;6;4;3;4;6;6;5;3;3;4;4;5;9;3;5;11;7;7;4;3;5;6;5;4;4;4;2;3;3;5;4;8;5;4;5;3;4;5;3;4;1;2;4;3;4;5;5;4;2;4;5;5;4;3;4;5;4;8;3;5;2;5;6;8;3;3;5;5;2;5;4;2;4;8;9;2;6;7;7;5;3;5;5;5;4;5;6;4;4;4;4;6;5;4;4;4;3;4;7;5;2;6;3;5;4;6;5;5;4;5;4;6;7;6;4;3;8;8;3;3;2;3;3;4;10;3;4;3;3;5; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0099503;GO:0034774;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0072562;GO:0044433;GO:0030141;GO:0097708;GO:0044446;GO:0044444;GO:0012505;GO:0005886;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:1903561;GO:0005615;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;secretory vesicle;secretory granule lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;blood microparticle;cytoplasmic vesicle part;secretory granule;intracellular vesicle;intracellular organelle part;cytoplasmic part;endomembrane system;plasma membrane;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;intracellular;cell periphery;extracellular exosome;extracellular vesicle;extracellular space;cellular_component;extracellular region; 2;4;4;5;2;5;6;5;3;4;3;3;2;2;3;3;2;3;4;4;4;3;4;3;3;5;4;5;6;5;2;2;3;3;4;3;3;1;2; GO:0008270;GO:0046872;GO:0097367;GO:0003674;GO:0005488;GO:0098772;GO:0046914;GO:0061135;GO:0043168;GO:0005102;GO:0004857;GO:0043169;GO:0043167;GO:0030414;GO:0061134;GO:0004866;GO:0004869;GO:0008201;GO:0005515;GO:1901681;GO:0005539;GO:0030234; zinc ion binding;metal ion binding;carbohydrate derivative binding;molecular_function;binding;molecular function regulator;transition metal ion binding;endopeptidase regulator activity;anion binding;receptor binding;enzyme inhibitor activity;cation binding;ion binding;peptidase inhibitor activity;peptidase regulator activity;endopeptidase inhibitor activity;cysteine-type endopeptidase inhibitor activity;heparin binding;protein binding;sulfur compound binding;glycosaminoglycan binding;enzyme regulator activity; 7;5;3;1;2;2;6;5;4;4;4;4;3;5;4;6;7;4;3;3;4;3; K03898 map04610; Complement and coagulation cascades; IPR002395;IPR000010;IPR018073;IPR027358; HMW kininogen;Cystatin domain;Proteinase inhibitor I25, cystatin, conserved site;Kininogen-type cystatin domain; extracellular 313125586 55.8 P [P] Inorganic ion transport and metabolism; COG4531 ABC-type Zn2+ transport system, periplasmic component/surface adhesin Q9BZX4 Ropporin-1B OS=Homo sapiens OX=9606 GN=ROPN1B PE=1 SV=1 - [ROP1B_HUMAN] 0.307 0.409 3.05 0.397 0.456 1.214 0.750611247 nan 0.870614035 nan 7.457212714 nan 2.662280702 nan GO:0016337;GO:0048232;GO:0044801;GO:0007165;GO:0019953;GO:0006928;GO:0061025;GO:0061024;GO:0007266;GO:0051674;GO:0022402;GO:0007276;GO:0035556;GO:0044802;GO:0044699;GO:0051716;GO:0007264;GO:0007340;GO:0000003;GO:0007342;GO:0050789;GO:0071840;GO:0016043;GO:0065007;GO:0051301;GO:0022610;GO:0040011;GO:0032501;GO:0048609;GO:0032504;GO:0098609;GO:0007049;GO:0030317;GO:0009987;GO:0050794;GO:0022414;GO:0007283;GO:0044763;GO:0007338;GO:0023052;GO:0022412;GO:0007155;GO:0045026;GO:0007265;GO:0051179;GO:0051704;GO:0000910;GO:0044700;GO:0044703;GO:0044702;GO:0098602;GO:0048870;GO:0050896;GO:0009566;GO:0007154;GO:0008150; single organismal cell-cell adhesion;male gamete generation;single-organism membrane fusion;signal transduction;sexual reproduction;movement of cell or subcellular component;membrane fusion;membrane organization;Rho protein signal transduction;localization of cell;cell cycle process;gamete generation;intracellular signal transduction;single-organism membrane organization;single-organism process;cellular response to stimulus;small GTPase mediated signal transduction;acrosome reaction;reproduction;fusion of sperm to egg plasma membrane;regulation of biological process;cellular component organization or biogenesis;cellular component organization;biological regulation;cell division;biological adhesion;locomotion;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cell-cell adhesion;cell cycle;sperm motility;cellular process;regulation of cellular process;reproductive process;spermatogenesis;single-organism cellular process;single fertilization;signaling;cellular process involved in reproduction in multicellular organism;cell adhesion;plasma membrane fusion;Ras protein signal transduction;localization;multi-organism process;cytokinesis;single organism signaling;multi-organism reproductive process;single organism reproductive process;single organism cell adhesion;cell motility;response to stimulus;fertilization;cell communication;biological_process; 4;5;5;4;3;4;5;4;8;3;4;4;5;4;2;3;6;3;2;5;2;2;3;2;4;2;2;2;3;3;4;4;4;2;3;2;6;3;5;2;4;3;6;7;2;2;5;3;3;3;3;3;2;4;4;1; GO:0044464;GO:0005929;GO:0043226;GO:0005737;GO:0031514;GO:0042995;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cell part;cilium;organelle;cytoplasm;motile cilium;cell projection;cell;intracellular;cellular_component;intracellular part; 2;3;2;4;4;3;2;3;1;3; GO:0003674;GO:0030159;GO:0005488;GO:0005198;GO:0042802;GO:0042803;GO:0005515;GO:0046983;GO:0046982;GO:0032947; molecular_function;receptor signaling complex scaffold activity;binding;structural molecule activity;identical protein binding;protein homodimerization activity;protein binding;protein dimerization activity;protein heterodimerization activity;protein complex scaffold; 1;4;2;2;4;5;3;4;5;3; IPR003117; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; cytosol A0JNW5 UHRF1-binding protein 1-like OS=Homo sapiens OX=9606 GN=UHRF1BP1L PE=1 SV=2 - [UH1BL_HUMAN] 1.012 1.119 0.89 1.146 1.087 0.843 0.90437891 0.534116953 1.054277829 0.743088237 0.795352994 0.273992077 0.775528979 0.512049964 IPR026854;IPR026728; Vacuolar protein sorting-associated protein 13, N-terminal domain;UHRF1-binding protein 1-like; plasma membrane Hs22058593_1 2726.0 S [S] Function unknown; Q14651 Plastin-1 OS=Homo sapiens OX=9606 GN=PLS1 PE=1 SV=2 - [PLSI_HUMAN] 0.804 1.739 0.529 1.604 0.869 0.672 0.462334675 nan 1.84579977 nan 0.304197815 nan 0.773302647 nan GO:0032880;GO:0008104;GO:0048589;GO:0061024;GO:0007009;GO:0035264;GO:0090003;GO:0031344;GO:0071840;GO:0070727;GO:0010256;GO:0048518;GO:0090002;GO:0032536;GO:0045184;GO:0072657;GO:0072659;GO:0003008;GO:0044707;GO:0008643;GO:0032532;GO:0032530;GO:0033036;GO:0022607;GO:0022600;GO:1902896;GO:0008645;GO:0016043;GO:0090066;GO:0065007;GO:1903829;GO:0065008;GO:0051130;GO:0070201;GO:0034613;GO:0050793;GO:0006810;GO:0050794;GO:0008150;GO:0051239;GO:0051234;GO:0030866;GO:0030865;GO:0032535;GO:0044802;GO:1903729;GO:0048639;GO:0048638;GO:0051128;GO:1903827;GO:0090004;GO:1990778;GO:0044699;GO:0051240;GO:0051641;GO:0032502;GO:0032501;GO:0009987;GO:1904377;GO:1904375;GO:0001951;GO:1904951;GO:0032879;GO:0051094;GO:0090150;GO:0045927;GO:0060341;GO:0030030;GO:0030036;GO:0050892;GO:0040008;GO:0050789;GO:0015758;GO:0044085;GO:0071702;GO:1903078;GO:0030029;GO:0007586;GO:1903076;GO:0032528;GO:0044767;GO:0044765;GO:0044763;GO:0070925;GO:0051179;GO:1902578;GO:0040007;GO:0006996;GO:0007010;GO:0040014;GO:0040018;GO:1902589;GO:0015749;GO:1902580;GO:0048522; regulation of protein localization;protein localization;developmental growth;membrane organization;plasma membrane organization;multicellular organism growth;regulation of establishment of protein localization to plasma membrane;regulation of cell projection organization;cellular component organization or biogenesis;cellular macromolecule localization;endomembrane system organization;positive regulation of biological process;establishment of protein localization to plasma membrane;regulation of cell projection size;establishment of protein localization;protein localization to membrane;protein localization to plasma membrane;system process;single-multicellular organism process;carbohydrate transport;regulation of microvillus length;regulation of microvillus organization;macromolecule localization;cellular component assembly;digestive system process;terminal web assembly;hexose transport;cellular component organization;regulation of anatomical structure size;biological regulation;positive regulation of cellular protein localization;regulation of biological quality;positive regulation of cellular component organization;regulation of establishment of protein localization;cellular protein localization;regulation of developmental process;transport;regulation of cellular process;biological_process;regulation of multicellular organismal process;establishment of localization;cortical actin cytoskeleton organization;cortical cytoskeleton organization;regulation of cellular component size;single-organism membrane organization;regulation of plasma membrane organization;positive regulation of developmental growth;regulation of developmental growth;regulation of cellular component organization;regulation of cellular protein localization;positive regulation of establishment of protein localization to plasma membrane;protein localization to cell periphery;single-organism process;positive regulation of multicellular organismal process;cellular localization;developmental process;multicellular organismal process;cellular process;positive regulation of protein localization to cell periphery;regulation of protein localization to cell periphery;intestinal D-glucose absorption;positive regulation of establishment of protein localization;regulation of localization;positive regulation of developmental process;establishment of protein localization to membrane;positive regulation of growth;regulation of cellular localization;cell projection organization;actin cytoskeleton organization;intestinal absorption;regulation of growth;regulation of biological process;glucose transport;cellular component biogenesis;organic substance transport;positive regulation of protein localization to plasma membrane;actin filament-based process;digestion;regulation of protein localization to plasma membrane;microvillus organization;single-organism developmental process;single-organism transport;single-organism cellular process;organelle assembly;localization;single-organism localization;growth;organelle organization;cytoskeleton organization;regulation of multicellular organism growth;positive regulation of multicellular organism growth;single-organism organelle organization;monosaccharide transport;single-organism cellular localization;positive regulation of cellular process; 4;4;3;4;5;4;6;5;2;4;4;2;6;5;4;5;6;3;3;5;6;6;3;4;4;6;7;3;4;2;3;3;4;5;5;3;4;3;1;3;3;6;6;4;4;5;4;4;4;5;4;6;2;3;3;2;2;2;4;6;5;3;3;3;5;3;4;4;5;4;3;2;8;3;5;5;4;4;6;5;3;4;3;5;2;3;2;4;5;4;4;4;6;4;3; GO:0031982;GO:0098862;GO:0043230;GO:0043232;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:1990357;GO:0005938;GO:0030863;GO:0030864;GO:0044446;GO:0044444;GO:0044448;GO:0005903;GO:0015629;GO:0005737;GO:1903561;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0099568;GO:0005575;GO:0005576; vesicle;cluster of actin-based cell projections;extracellular organelle;intracellular non-membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;terminal web;cell cortex;cortical cytoskeleton;cortical actin cytoskeleton;intracellular organelle part;cytoplasmic part;cell cortex part;brush border;actin cytoskeleton;cytoplasm;extracellular vesicle;cell part;cell;intracellular;cell periphery;extracellular exosome;cytoplasmic region;cellular_component;extracellular region; 4;3;3;4;3;2;2;3;3;3;2;5;4;6;4;6;5;3;4;5;4;6;4;3;2;2;3;3;4;5;1;2; GO:0005198;GO:0003674;GO:0005488;GO:0003779;GO:0008092;GO:0043169;GO:0043167;GO:0005509;GO:0032403;GO:0051015;GO:0046872;GO:0005515;GO:0044877;GO:0005200; structural molecule activity;molecular_function;binding;actin binding;cytoskeletal protein binding;cation binding;ion binding;calcium ion binding;protein complex binding;actin filament binding;metal ion binding;protein binding;macromolecular complex binding;structural constituent of cytoskeleton; 2;1;2;5;4;4;3;6;4;5;5;3;3;3; K17275 IPR018247;IPR001715;IPR011992;IPR001589;IPR030235;IPR002048; EF-Hand 1, calcium-binding site;Calponin homology domain;EF-hand domain pair;Actinin-type actin-binding domain, conserved site;Plastin-1;EF-hand domain; cytosol Hs4505897 1280.0 Z [Z] Cytoskeleton; Q8N1F7 Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2 - [NUP93_HUMAN] 1.029 0.861 1.105 1.116 1.044 0.936 1.195121951 0.365658622 1.068965517 0.514303756 1.283391405 0.405214942 0.896551724 0.738189983 GO:0051169;GO:0051168;GO:0019221;GO:0019222;GO:0051049;GO:0034605;GO:0043412;GO:0048583;GO:0098779;GO:0061024;GO:0071705;GO:0007165;GO:0007166;GO:0044744;GO:1901362;GO:1901360;GO:0050688;GO:0044712;GO:0015758;GO:0051716;GO:0016925;GO:0010605;GO:0070727;GO:0009615;GO:0010256;GO:0071310;GO:0018193;GO:0044419;GO:0032446;GO:0016458;GO:0019058;GO:0051817;GO:0048519;GO:0051704;GO:0019054;GO:0034470;GO:0032101;GO:0060255;GO:0006606;GO:0030397;GO:0006605;GO:0045184;GO:0007077;GO:0051701;GO:0051707;GO:0010033;GO:0046483;GO:0044700;GO:0009607;GO:0009605;GO:0019538;GO:0010468;GO:0002376;GO:0018205;GO:0033554;GO:0019438;GO:0044281;GO:0022607;GO:0009892;GO:0019080;GO:0044068;GO:0019083;GO:0006997;GO:1903008;GO:0008104;GO:0006807;GO:0044033;GO:0034660;GO:0051028;GO:0000278;GO:1901576;GO:0016973;GO:0044260;GO:0043900;GO:0008645;GO:0006886;GO:0016043;GO:0008643;GO:0065003;GO:0065007;GO:0071840;GO:0065008;GO:0018130;GO:0006461;GO:0034097;GO:0006810;GO:0044710;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0009266;GO:0034654;GO:0051236;GO:0031347;GO:0051234;GO:0046931;GO:0016070;GO:0050658;GO:0044271;GO:0043207;GO:0046907;GO:0071345;GO:0050896;GO:0080135;GO:0044765;GO:0072594;GO:0002697;GO:0044764;GO:0022411;GO:0015931;GO:0071166;GO:0032774;GO:0070271;GO:0070647;GO:0017038;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0007005;GO:0044699;GO:0006139;GO:0043623;GO:0051081;GO:0051179;GO:0008033;GO:0051170;GO:0009628;GO:0016236;GO:0043687;GO:0009987;GO:0006725;GO:1902582;GO:0098542;GO:0009408;GO:0032879;GO:0044802;GO:0055085;GO:0051607;GO:0007049;GO:0033036;GO:0000422;GO:0000423;GO:1900034;GO:0010629;GO:0043170;GO:0002230;GO:0033365;GO:0080134;GO:0034504;GO:0043933;GO:0019048;GO:1903047;GO:0050657;GO:0090304;GO:0010827;GO:0022402;GO:0006998;GO:0034622;GO:0002682;GO:0071822;GO:0006399;GO:1902593;GO:0050789;GO:0098780;GO:0071704;GO:0010467;GO:0071702;GO:0006403;GO:0006405;GO:0006406;GO:0002831;GO:0015749;GO:0044267;GO:0061726;GO:0006914;GO:0034613;GO:0006913;GO:0006464;GO:0050691;GO:0009058;GO:0009059;GO:0044763;GO:0031047;GO:0051649;GO:0007154;GO:0051292;GO:0009056;GO:0044003;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0071426;GO:0071427;GO:0044237;GO:0006999;GO:1902589;GO:0044085;GO:0098792;GO:0016032;GO:0002252;GO:0015031;GO:0044403;GO:1902580;GO:0035821;GO:0006396; nuclear transport;nuclear export;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of transport;cellular response to heat;macromolecule modification;regulation of response to stimulus;mitophagy in response to mitochondrial depolarization;membrane organization;nitrogen compound transport;signal transduction;cell surface receptor signaling pathway;protein targeting to nucleus;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of defense response to virus;single-organism catabolic process;glucose transport;cellular response to stimulus;protein sumoylation;negative regulation of macromolecule metabolic process;cellular macromolecule localization;response to virus;endomembrane system organization;cellular response to organic substance;peptidyl-amino acid modification;interspecies interaction between organisms;protein modification by small protein conjugation;gene silencing;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of biological process;multi-organism process;modulation by virus of host process;ncRNA processing;regulation of response to external stimulus;regulation of macromolecule metabolic process;protein import into nucleus;membrane disassembly;protein targeting;establishment of protein localization;mitotic nuclear envelope disassembly;interaction with host;response to other organism;response to organic substance;heterocycle metabolic process;single organism signaling;response to biotic stimulus;response to external stimulus;protein metabolic process;regulation of gene expression;immune system process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;small molecule metabolic process;cellular component assembly;negative regulation of metabolic process;viral gene expression;modulation by symbiont of host cellular process;viral transcription;nucleus organization;organelle disassembly;protein localization;nitrogen compound metabolic process;multi-organism metabolic process;ncRNA metabolic process;mRNA transport;mitotic cell cycle;organic substance biosynthetic process;poly(A)+ mRNA export from nucleus;cellular macromolecule metabolic process;regulation of multi-organism process;hexose transport;intracellular protein transport;cellular component organization;carbohydrate transport;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;regulation of biological quality;heterocycle biosynthetic process;protein complex assembly;response to cytokine;transport;single-organism metabolic process;regulation of cellular process;defense response;response to stress;protein modification process;biological_process;metabolic process;response to temperature stimulus;nucleobase-containing compound biosynthetic process;establishment of RNA localization;regulation of defense response;establishment of localization;pore complex assembly;RNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;response to external biotic stimulus;intracellular transport;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;single-organism transport;establishment of protein localization to organelle;regulation of immune effector process;multi-organism cellular process;cellular component disassembly;nucleobase-containing compound transport;ribonucleoprotein complex localization;RNA biosynthetic process;protein complex biogenesis;protein modification by small protein conjugation or removal;protein import;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;mitochondrion organization;single-organism process;nucleobase-containing compound metabolic process;cellular protein complex assembly;nuclear envelope disassembly;localization;tRNA processing;nuclear import;response to abiotic stimulus;macroautophagy;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;single-organism intracellular transport;defense response to other organism;response to heat;regulation of localization;single-organism membrane organization;transmembrane transport;defense response to virus;cell cycle;macromolecule localization;mitophagy;macromitophagy;regulation of cellular response to heat;negative regulation of gene expression;macromolecule metabolic process;positive regulation of defense response to virus by host;protein localization to organelle;regulation of response to stress;protein localization to nucleus;macromolecular complex subunit organization;modulation by virus of host morphology or physiology;mitotic cell cycle process;nucleic acid transport;nucleic acid metabolic process;regulation of glucose transport;cell cycle process;nuclear envelope organization;cellular macromolecular complex assembly;regulation of immune system process;protein complex subunit organization;tRNA metabolic process;single-organism nuclear import;regulation of biological process;response to mitochondrial depolarisation;organic substance metabolic process;gene expression;organic substance transport;RNA localization;RNA export from nucleus;mRNA export from nucleus;regulation of response to biotic stimulus;monosaccharide transport;cellular protein metabolic process;mitochondrion disassembly;autophagy;cellular protein localization;nucleocytoplasmic transport;cellular protein modification process;regulation of defense response to virus by host;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;gene silencing by RNA;establishment of localization in cell;cell communication;nuclear pore complex assembly;catabolic process;modification by symbiont of host morphology or physiology;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;ribonucleoprotein complex export from nucleus;mRNA-containing ribonucleoprotein complex export from nucleus;cellular metabolic process;nuclear pore organization;single-organism organelle organization;cellular component biogenesis;xenophagy;viral process;immune effector process;protein transport;symbiosis, encompassing mutualism through parasitism;single-organism cellular localization;modification of morphology or physiology of other organism;RNA processing; 6;8;6;3;4;5;5;3;6;4;5;4;5;5;5;4;4;4;8;3;9;4;4;4;4;5;7;3;8;4;5;4;2;2;5;7;4;4;5;5;6;4;6;4;3;4;4;3;3;3;4;5;2;8;4;5;4;4;3;4;4;5;5;5;4;3;3;6;6;5;4;6;4;3;7;6;3;5;5;2;2;3;5;5;5;4;3;3;4;3;5;1;2;4;5;4;5;3;6;5;5;5;4;5;6;2;4;4;5;4;3;4;6;4;6;4;7;5;4;4;2;4;3;5;2;4;6;6;2;8;8;3;4;7;2;4;5;4;4;3;4;4;4;4;3;4;5;5;5;4;6;6;4;7;4;5;5;7;5;5;4;5;6;3;5;7;6;2;5;3;5;5;4;6;6;4;6;5;6;3;5;7;6;5;3;5;3;5;4;4;7;3;5;3;3;4;3;4;5;6;3;6;4;3;5;4;3;5;4;4;3;6; GO:0031974;GO:0031975;GO:0031981;GO:0016020;GO:0031967;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0044446;GO:0034399;GO:0031090;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005643;GO:0031965;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;nuclear lumen;membrane;organelle envelope;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;intracellular organelle part;nuclear periphery;organelle membrane;nucleus;nuclear envelope;cell part;cell;nuclear pore;nuclear membrane;cellular_component;intracellular organelle lumen; 2;3;5;2;4;4;3;4;3;2;3;3;3;2;3;3;5;3;5;4;2;2;5;4;1;4; GO:0005198;GO:0003674;GO:0017056; structural molecule activity;molecular_function;structural constituent of nuclear pore; 2;1;3; K14309 map03013; RNA transport; IPR007231;IPR011990; Nucleoporin interacting component Nup93/Nic96;Tetratricopeptide-like helical domain; cytosol Hs7661902 1697.0 D [D] Cell cycle control, cell division, chromosome partitioning; Q9NU02 Ankyrin repeat and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKEF1 PE=2 SV=2 - [ANKE1_HUMAN] 1.367 0.904 0.731 1.311 0.982 0.811 1.512168142 0.030096801 1.33503055 0.343442723 0.808628319 0.229194126 0.82586558 0.048313621 GO:0043169;GO:0043167;GO:0003674;GO:0005488;GO:0046872;GO:0005509; cation binding;ion binding;molecular_function;binding;metal ion binding;calcium ion binding; 4;3;1;2;5;6; IPR011992;IPR002110;IPR002048;IPR020683; EF-hand domain pair;Ankyrin repeat;EF-hand domain;Ankyrin repeat-containing domain; cytosol Hs21314697 1606.0 M [M] Cell wall/membrane/envelope biogenesis; A0A0B4J1U7 Immunoglobulin heavy variable 6-1 OS=Homo sapiens OX=9606 GN=IGHV6-1 PE=3 SV=1 - [HV601_HUMAN] 1.099 0.87 0.963 1.072 0.915 1.616 1.263218391 0.115037567 1.171584699 0.72706746 1.106896552 0.160994616 1.766120219 0.002540716 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q96EW2 HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1 - [HBAP1_HUMAN] 1.272 1.128 0.223 1.984 0.927 0.974 1.127659574 nan 2.140237325 nan 0.197695035 nan 1.050701187 nan GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; K19375 IPR013296;IPR003347; HSPB1-associated protein 1;JmjC domain; cytosol Hs21314714_1 615.0 BT [B] Chromatin structure and dynamics;[T] Signal transduction mechanisms; P06396 Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1 - [GELS_HUMAN] 0.998 1.112 0.964 0.935 1.151 0.86 0.897482014 7.16E-10 0.812337098 2.57E-19 0.866906475 0.008501269 0.747176368 0.080664537 GO:0006909;GO:0008064;GO:0044858;GO:0051651;GO:0044856;GO:0043200;GO:0051716;GO:0048589;GO:0051495;GO:0051494;GO:0051493;GO:0090527;GO:0048468;GO:0065008;GO:0009605;GO:0019538;GO:0010638;GO:0010639;GO:0009893;GO:0035556;GO:0050789;GO:0000902;GO:0051345;GO:0044855;GO:0002682;GO:0098602;GO:0098609;GO:0048709;GO:0032956;GO:0048869;GO:0044802;GO:0097305;GO:0051127;GO:0051125;GO:0071248;GO:0001775;GO:0071241;GO:0051129;GO:0051128;GO:1903827;GO:0010001;GO:0043244;GO:0043241;GO:0014070;GO:0043242;GO:1904019;GO:0097194;GO:0033273;GO:0070293;GO:0051016;GO:0051014;GO:0044319;GO:0060341;GO:0030030;GO:0097190;GO:0030036;GO:0022407;GO:0061041;GO:0008219;GO:0007275;GO:2000116;GO:2000114;GO:0043065;GO:0043067;GO:0043062;GO:0046686;GO:1903319;GO:0097283;GO:0097284;GO:0043068;GO:1902172;GO:1902174;GO:0006461;GO:0032984;GO:0044767;GO:0044765;GO:0044764;GO:0044763;GO:0010950;GO:0010952;GO:0010954;GO:0040011;GO:0040013;GO:0051270;GO:0048858;GO:0048856;GO:0002011;GO:0048525;GO:0043113;GO:0048523;GO:0048522;GO:0008104;GO:0034110;GO:0003012;GO:0007163;GO:0003014;GO:0007165;GO:0044710;GO:0033043;GO:1903689;GO:0044093;GO:0033036;GO:0051665;GO:0010038;GO:0051668;GO:0051701;GO:0010033;GO:0051704;GO:0031667;GO:0046718;GO:0045321;GO:0010628;GO:0001766;GO:0001767;GO:0001768;GO:0044267;GO:0009653;GO:0044260;GO:1900756;GO:0060271;GO:0050793;GO:0050792;GO:0050790;GO:0009888;GO:0050794;GO:0071801;GO:0051235;GO:0051234;GO:0051336;GO:0006897;GO:0050896;GO:1990000;GO:0002694;GO:2000145;GO:0014891;GO:0097017;GO:1903317;GO:0070271;GO:0031099;GO:0070887;GO:0044699;GO:0032880;GO:0071800;GO:0051249;GO:0051246;GO:0051247;GO:1903034;GO:1903037;GO:1901700;GO:0040012;GO:0010324;GO:0051674;GO:0016337;GO:0050865;GO:0050863;GO:0046596;GO:0046597;GO:0034622;GO:0031532;GO:0030029;GO:0052547;GO:0052548;GO:0045471;GO:0070489;GO:0042221;GO:0022008;GO:0070486;GO:0043623;GO:0051806;GO:0006996;GO:0044238;GO:0052192;GO:0044237;GO:0044409;GO:0044403;GO:2001235;GO:0019222;GO:2001233;GO:0048584;GO:0048583;GO:0090066;GO:0071840;GO:0009966;GO:0009967;GO:0019058;GO:0048518;GO:0048519;GO:0031580;GO:1901880;GO:0045185;GO:0072657;GO:0003008;GO:0044700;GO:0016192;GO:0044707;GO:0010243;GO:0002376;GO:0032535;GO:0022607;GO:0006921;GO:0022603;GO:0006928;GO:0042989;GO:0042981;GO:0031579;GO:1904035;GO:1904037;GO:0016477;GO:0006810;GO:0012501;GO:0006950;GO:0043901;GO:0048731;GO:0048015;GO:0048017;GO:0070613;GO:0051604;GO:0043903;GO:0080134;GO:0043900;GO:0030155;GO:0030154;GO:0030010;GO:0009719;GO:0014889;GO:0097435;GO:0043933;GO:0032270;GO:0032271;GO:0032272;GO:0032273;GO:0006508;GO:0051693;GO:0032502;GO:0032501;GO:0032507;GO:0031333;GO:0031334;GO:0016485;GO:0032878;GO:0032879;GO:0051258;GO:0090504;GO:0090505;GO:0051828;GO:0042110;GO:0043500;GO:0030832;GO:0030833;GO:0030834;GO:0030835;GO:0045010;GO:0030837;GO:0030838;GO:0032989;GO:0071704;GO:0048729;GO:0030334;GO:0007584;GO:0034613;GO:0006911;GO:0070925;GO:0051179;GO:1902578;GO:0051641;GO:1902589;GO:1902580;GO:0006915;GO:0080090;GO:0061024;GO:0010035;GO:0010604;GO:0070727;GO:0009611;GO:0044419;GO:0043281;GO:0043280;GO:0060255;GO:0051593;GO:0046649;GO:0030162;GO:0030041;GO:0030042;GO:0048870;GO:0042246;GO:0030198;GO:0021782;GO:1901879;GO:0035313;GO:0016043;GO:0065003;GO:0065007;GO:0065009;GO:0071593;GO:0051130;GO:0042063;GO:0042060;GO:0071276;GO:0008154;GO:0014888;GO:0008150;GO:0008152;GO:0014003;GO:0043254;GO:0031648;GO:1901698;GO:0031647;GO:0022411;GO:0023056;GO:0030260;GO:0023052;GO:0023051;GO:0052126;GO:0010647;GO:0010646;GO:0043085;GO:0007417;GO:1903906;GO:0043624;GO:1903900;GO:1903901;GO:1903903;GO:1903909;GO:0022610;GO:0060429;GO:0001101;GO:2001056;GO:0007010;GO:0032268;GO:0007568;GO:0043170;GO:0045862;GO:0009987;GO:0009991;GO:0031325;GO:0031323;GO:0010942;GO:0010941;GO:0002009;GO:0040007;GO:0071822;GO:0051261;GO:2001267;GO:0010467;GO:0044085;GO:1902115;GO:0010468;GO:2001269;GO:0032970;GO:1903923;GO:0034109;GO:1903921;GO:0007159;GO:0007155;GO:0007154;GO:0007015;GO:0032990;GO:0007399;GO:0044087;GO:0016032;GO:0044089; phagocytosis;regulation of actin polymerization or depolymerization;plasma membrane raft polarization;maintenance of location in cell;plasma membrane raft localization;response to amino acid;cellular response to stimulus;developmental growth;positive regulation of cytoskeleton organization;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;actin filament reorganization;cell development;regulation of biological quality;response to external stimulus;protein metabolic process;positive regulation of organelle organization;negative regulation of organelle organization;positive regulation of metabolic process;intracellular signal transduction;regulation of biological process;cell morphogenesis;positive regulation of hydrolase activity;plasma membrane raft distribution;regulation of immune system process;single organism cell adhesion;cell-cell adhesion;oligodendrocyte differentiation;regulation of actin cytoskeleton organization;cellular developmental process;single-organism membrane organization;response to alcohol;positive regulation of actin nucleation;regulation of actin nucleation;cellular response to metal ion;cell activation;cellular response to inorganic substance;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;glial cell differentiation;regulation of protein complex disassembly;protein complex disassembly;response to organic cyclic compound;negative regulation of protein complex disassembly;epithelial cell apoptotic process;execution phase of apoptosis;response to vitamin;renal absorption;barbed-end actin filament capping;actin filament severing;wound healing, spreading of cells;regulation of cellular localization;cell projection organization;apoptotic signaling pathway;actin cytoskeleton organization;regulation of cell-cell adhesion;regulation of wound healing;cell death;multicellular organism development;regulation of cysteine-type endopeptidase activity;regulation of establishment of cell polarity;positive regulation of apoptotic process;regulation of programmed cell death;extracellular structure organization;response to cadmium ion;positive regulation of protein maturation;keratinocyte apoptotic process;hepatocyte apoptotic process;positive regulation of programmed cell death;regulation of keratinocyte apoptotic process;positive regulation of keratinocyte apoptotic process;protein complex assembly;macromolecular complex disassembly;single-organism developmental process;single-organism transport;multi-organism cellular process;single-organism cellular process;positive regulation of endopeptidase activity;positive regulation of peptidase activity;positive regulation of protein processing;locomotion;negative regulation of locomotion;regulation of cellular component movement;cell projection morphogenesis;anatomical structure development;morphogenesis of an epithelial sheet;negative regulation of viral process;receptor clustering;negative regulation of cellular process;positive regulation of cellular process;protein localization;regulation of homotypic cell-cell adhesion;muscle system process;establishment or maintenance of cell polarity;renal system process;signal transduction;single-organism metabolic process;regulation of organelle organization;regulation of wound healing, spreading of epidermal cells;positive regulation of molecular function;macromolecule localization;membrane raft localization;response to metal ion;localization within membrane;interaction with host;response to organic substance;multi-organism process;response to nutrient levels;viral entry into host cell;leukocyte activation;positive regulation of gene expression;membrane raft polarization;establishment of lymphocyte polarity;establishment of T cell polarity;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;protein processing in phagocytic vesicle;cilium morphogenesis;regulation of developmental process;regulation of viral process;regulation of catalytic activity;tissue development;regulation of cellular process;regulation of podosome assembly;maintenance of location;establishment of localization;regulation of hydrolase activity;endocytosis;response to stimulus;amyloid fibril formation;regulation of leukocyte activation;regulation of cell motility;striated muscle atrophy;renal protein absorption;regulation of protein maturation;protein complex biogenesis;regeneration;cellular response to chemical stimulus;single-organism process;regulation of protein localization;podosome assembly;regulation of lymphocyte activation;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of response to wounding;regulation of leukocyte cell-cell adhesion;response to oxygen-containing compound;regulation of locomotion;membrane invagination;localization of cell;single organismal cell-cell adhesion;regulation of cell activation;regulation of T cell activation;regulation of viral entry into host cell;negative regulation of viral entry into host cell;cellular macromolecular complex assembly;actin cytoskeleton reorganization;actin filament-based process;regulation of peptidase activity;regulation of endopeptidase activity;response to ethanol;T cell aggregation;response to chemical;neurogenesis;leukocyte aggregation;cellular protein complex assembly;entry into cell of other organism involved in symbiotic interaction;organelle organization;primary metabolic process;movement in environment of other organism involved in symbiotic interaction;cellular metabolic process;entry into host;symbiosis, encompassing mutualism through parasitism;positive regulation of apoptotic signaling pathway;regulation of metabolic process;regulation of apoptotic signaling pathway;positive regulation of response to stimulus;regulation of response to stimulus;regulation of anatomical structure size;cellular component organization or biogenesis;regulation of signal transduction;positive regulation of signal transduction;viral life cycle;positive regulation of biological process;negative regulation of biological process;membrane raft distribution;negative regulation of protein depolymerization;maintenance of protein location;protein localization to membrane;system process;single organism signaling;vesicle-mediated transport;single-multicellular organism process;response to organonitrogen compound;immune system process;regulation of cellular component size;cellular component assembly;cellular component disassembly involved in execution phase of apoptosis;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;sequestering of actin monomers;regulation of apoptotic process;membrane raft organization;regulation of epithelial cell apoptotic process;positive regulation of epithelial cell apoptotic process;cell migration;transport;programmed cell death;response to stress;negative regulation of multi-organism process;system development;phosphatidylinositol-mediated signaling;inositol lipid-mediated signaling;regulation of protein processing;protein maturation;regulation of symbiosis, encompassing mutualism through parasitism;regulation of response to stress;regulation of multi-organism process;regulation of cell adhesion;cell differentiation;establishment of cell polarity;response to endogenous stimulus;muscle atrophy;fibril organization;macromolecular complex subunit organization;positive regulation of cellular protein metabolic process;regulation of protein polymerization;negative regulation of protein polymerization;positive regulation of protein polymerization;proteolysis;actin filament capping;developmental process;multicellular organismal process;maintenance of protein location in cell;negative regulation of protein complex assembly;positive regulation of protein complex assembly;protein processing;regulation of establishment or maintenance of cell polarity;regulation of localization;protein polymerization;epiboly;epiboly involved in wound healing;entry into other organism involved in symbiotic interaction;T cell activation;muscle adaptation;regulation of actin filament length;regulation of actin filament polymerization;regulation of actin filament depolymerization;negative regulation of actin filament depolymerization;actin nucleation;negative regulation of actin filament polymerization;positive regulation of actin filament polymerization;cellular component morphogenesis;organic substance metabolic process;tissue morphogenesis;regulation of cell migration;response to nutrient;cellular protein localization;phagocytosis, engulfment;organelle assembly;localization;single-organism localization;cellular localization;single-organism organelle organization;single-organism cellular localization;apoptotic process;regulation of primary metabolic process;membrane organization;response to inorganic substance;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to wounding;interspecies interaction between organisms;regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of macromolecule metabolic process;response to folic acid;lymphocyte activation;regulation of proteolysis;actin filament polymerization;actin filament depolymerization;cell motility;tissue regeneration;extracellular matrix organization;glial cell development;regulation of protein depolymerization;wound healing, spreading of epidermal cells;cellular component organization;macromolecular complex assembly;biological regulation;regulation of molecular function;lymphocyte aggregation;positive regulation of cellular component organization;gliogenesis;wound healing;cellular response to cadmium ion;actin polymerization or depolymerization;striated muscle adaptation;biological_process;metabolic process;oligodendrocyte development;regulation of protein complex assembly;protein destabilization;response to nitrogen compound;regulation of protein stability;cellular component disassembly;positive regulation of signaling;entry into host cell;signaling;regulation of signaling;movement in host environment;positive regulation of cell communication;regulation of cell communication;positive regulation of catalytic activity;central nervous system development;regulation of plasma membrane raft polarization;cellular protein complex disassembly;regulation of viral life cycle;negative regulation of viral life cycle;regulation of establishment of T cell polarity;regulation of receptor clustering;biological adhesion;epithelium development;response to acid chemical;positive regulation of cysteine-type endopeptidase activity;cytoskeleton organization;regulation of cellular protein metabolic process;aging;macromolecule metabolic process;positive regulation of proteolysis;cellular process;response to extracellular stimulus;positive regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of cell death;regulation of cell death;morphogenesis of an epithelium;growth;protein complex subunit organization;protein depolymerization;regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;gene expression;cellular component biogenesis;regulation of organelle assembly;regulation of gene expression;positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;regulation of actin filament-based process;positive regulation of protein processing in phagocytic vesicle;homotypic cell-cell adhesion;regulation of protein processing in phagocytic vesicle;leukocyte cell-cell adhesion;cell adhesion;cell communication;actin filament organization;cell part morphogenesis;nervous system development;regulation of cellular component biogenesis;viral process;positive regulation of cellular component biogenesis; 5;6;7;4;6;5;3;3;6;6;6;7;4;3;3;4;5;5;3;5;2;5;6;6;3;3;4;6;5;4;4;5;7;7;6;4;5;4;4;5;6;5;6;5;5;7;4;5;5;9;5;5;4;4;5;5;5;6;4;4;8;5;6;5;4;6;6;8;8;5;8;8;5;5;3;4;3;3;8;7;7;2;3;4;5;3;6;4;5;3;3;4;6;4;4;4;4;3;5;5;4;3;5;5;4;4;4;2;5;6;3;5;6;5;6;5;3;4;7;6;3;4;4;4;3;5;3;3;5;6;2;4;4;4;5;6;6;4;4;4;2;4;6;5;5;5;5;6;4;3;5;3;4;4;6;4;4;6;6;4;6;7;6;4;3;6;6;6;5;4;3;3;3;5;4;5;3;5;3;3;4;2;4;4;5;2;2;5;6;4;5;3;3;5;3;4;2;4;4;5;4;4;6;6;5;7;7;4;4;5;3;3;4;7;6;7;5;4;4;3;4;5;5;3;4;6;4;5;5;6;5;5;8;2;2;5;5;4;6;4;3;7;7;6;4;5;3;5;6;7;7;7;7;6;4;3;4;5;4;5;6;5;2;3;3;4;4;6;4;4;4;4;4;4;3;7;7;4;6;4;6;8;8;3;4;5;5;6;6;3;5;2;3;7;4;7;5;7;7;4;1;2;6;4;5;4;4;4;3;6;2;3;4;4;4;5;5;5;7;5;5;6;5;2;5;4;9;5;5;4;4;6;2;4;4;4;4;4;5;2;5;8;6;5;3;4;5;6;4;8;5;8;5;3;4;6;5;5;3;4;3; GO:0043209;GO:0048471;GO:0044424;GO:0044421;GO:0044422;GO:0030054;GO:0070161;GO:0031252;GO:0005912;GO:0044464;GO:0016528;GO:0071944;GO:0001726;GO:0005615;GO:0070062;GO:0042995;GO:0043234;GO:0043230;GO:0043232;GO:0005829;GO:0005924;GO:0005925;GO:0072562;GO:0044430;GO:0099568;GO:0043227;GO:0030055;GO:0043229;GO:0043228;GO:0005622;GO:0043226;GO:0005856;GO:0030478;GO:0005938;GO:0031982;GO:0044446;GO:0044444;GO:0044448;GO:0016020;GO:0002102;GO:0015629;GO:0030027;GO:0005737;GO:0030863;GO:0030864;GO:0005623;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005576; myelin sheath;perinuclear region of cytoplasm;intracellular part;extracellular region part;organelle part;cell junction;anchoring junction;cell leading edge;adherens junction;cell part;sarcoplasm;cell periphery;ruffle;extracellular space;extracellular exosome;cell projection;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;cell-substrate adherens junction;focal adhesion;blood microparticle;cytoskeletal part;cytoplasmic region;membrane-bounded organelle;cell-substrate junction;intracellular organelle;non-membrane-bounded organelle;intracellular;organelle;cytoskeleton;actin cap;cell cortex;vesicle;intracellular organelle part;cytoplasmic part;cell cortex part;membrane;podosome;actin cytoskeleton;lamellipodium;cytoplasm;cortical cytoskeleton;cortical actin cytoskeleton;cell;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 3;5;3;2;2;2;3;3;4;2;5;3;4;3;4;3;3;3;4;5;4;5;3;4;5;3;3;3;3;3;2;5;5;4;4;3;4;5;2;4;6;4;4;6;5;2;3;3;2;1;2; GO:0005488;GO:0003779;GO:0005509;GO:0005515;GO:0003674;GO:0046872;GO:0019904;GO:0017022;GO:0043169;GO:0043167;GO:0008092;GO:0045159; binding;actin binding;calcium ion binding;protein binding;molecular_function;metal ion binding;protein domain specific binding;myosin binding;cation binding;ion binding;cytoskeletal protein binding;myosin II binding; 2;5;6;3;1;5;4;5;4;3;4;6; K05768 map04666;map04810;map05203; Fc gamma R-mediated phagocytosis;Regulation of actin cytoskeleton;Viral carcinogenesis; IPR029006;IPR007122;IPR007123;IPR030004; ADF-H/Gelsolin-like domain;Villin/Gelsolin;Gelsolin-like domain;Gelsolin; endoplasmic reticulum Hs4504165 1621.0 Z [Z] Cytoskeleton; Q05469 Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4 - [LIPS_HUMAN] 1.223 0.868 0.953 1.133 1.049 0.922 1.408986175 nan 1.080076263 nan 1.097926267 nan 0.878932316 nan GO:0046340;GO:0042758;GO:0044281;GO:0044282;GO:1901360;GO:0044712;GO:0044710;GO:0046503;GO:0032787;GO:1902652;GO:0072329;GO:0043436;GO:0046486;GO:0046339;GO:0019538;GO:0019433;GO:0016054;GO:0009062;GO:0043170;GO:0044267;GO:1901575;GO:0044260;GO:0016042;GO:0006629;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0001676;GO:0046395;GO:1901615;GO:0006631;GO:0016310;GO:0006639;GO:0006638;GO:0044248;GO:0044242;GO:0044699;GO:0046464;GO:0046461;GO:0016125;GO:0006641;GO:0009987;GO:0044255;GO:0008202;GO:0008203;GO:0006082;GO:0019752;GO:0006066;GO:0071704;GO:0006468;GO:0006464;GO:0044763;GO:0009056;GO:0044238;GO:0044237;GO:0006796;GO:0006793; diacylglycerol catabolic process;long-chain fatty acid catabolic process;small molecule metabolic process;small molecule catabolic process;organic cyclic compound metabolic process;single-organism catabolic process;single-organism metabolic process;glycerolipid catabolic process;monocarboxylic acid metabolic process;secondary alcohol metabolic process;monocarboxylic acid catabolic process;oxoacid metabolic process;glycerolipid metabolic process;diacylglycerol metabolic process;protein metabolic process;triglyceride catabolic process;organic acid catabolic process;fatty acid catabolic process;macromolecule metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;lipid catabolic process;lipid metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;long-chain fatty acid metabolic process;carboxylic acid catabolic process;organic hydroxy compound metabolic process;fatty acid metabolic process;phosphorylation;acylglycerol metabolic process;neutral lipid metabolic process;cellular catabolic process;cellular lipid catabolic process;single-organism process;acylglycerol catabolic process;neutral lipid catabolic process;sterol metabolic process;triglyceride metabolic process;cellular process;cellular lipid metabolic process;steroid metabolic process;cholesterol metabolic process;organic acid metabolic process;carboxylic acid metabolic process;alcohol metabolic process;organic substance metabolic process;protein phosphorylation;cellular protein modification process;single-organism cellular process;catabolic process;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process; 8;7;4;5;4;4;3;6;7;6;7;5;5;7;4;8;5;6;4;5;4;4;5;4;5;5;1;2;6;6;4;5;6;6;5;4;5;2;7;6;6;7;2;4;5;7;4;6;5;3;7;6;3;3;3;3;5;4; GO:0044853;GO:0016020;GO:0098589;GO:0043232;GO:0005829;GO:0044424;GO:0044425;GO:0098857;GO:0098590;GO:0043229;GO:0043228;GO:0043226;GO:0044444;GO:0005901;GO:0005737;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098805;GO:0005811;GO:0005886;GO:0045121;GO:0005575; plasma membrane raft;membrane;membrane region;intracellular non-membrane-bounded organelle;cytosol;intracellular part;membrane part;membrane microdomain;plasma membrane region;intracellular organelle;non-membrane-bounded organelle;organelle;cytoplasmic part;caveola;cytoplasm;plasma membrane part;cell part;cell;intracellular;cell periphery;whole membrane;lipid particle;plasma membrane;membrane raft;cellular_component; 4;2;3;4;5;3;2;4;4;3;3;2;4;5;4;3;2;2;3;3;3;5;3;5;1; GO:0016298;GO:0003674;GO:0016787;GO:0016788;GO:0003824;GO:0033878;GO:0052689;GO:0004806; lipase activity;molecular_function;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;hormone-sensitive lipase activity;carboxylic ester hydrolase activity;triglyceride lipase activity; 5;1;3;4;2;6;5;6; K07188 map04024;map04152;map04910;map04923;map04925; cAMP signaling pathway;AMPK signaling pathway;Insulin signaling pathway;Regulation of lipolysis in adipocytes;Aldosterone synthesis and secretion; IPR013094;IPR002168;IPR029058;IPR033140;IPR010468; Alpha/beta hydrolase fold-3;Lipase, GDXG, putative histidine active site;Alpha/Beta hydrolase fold;Lipase, GDXG, putative serine active site;Hormone-sensitive lipase, N-terminal; nucleus Hs21328446 2195.0 I [I] Lipid transport and metabolism; P03951 Coagulation factor XI OS=Homo sapiens OX=9606 GN=F11 PE=1 SV=1 - [FA11_HUMAN] 1.135 1.022 0.934 1.118 1.007 0.831 1.110567515 0.58421655 1.110228401 0.199274386 0.913894325 0.799422644 0.825223436 0.244523282 GO:0007599;GO:0007597;GO:0007596;GO:0048583;GO:0044710;GO:0009611;GO:0048519;GO:0048585;GO:0044707;GO:0009605;GO:0019538;GO:0030193;GO:0030195;GO:1900046;GO:1900047;GO:0065007;GO:0065008;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:0050818;GO:0050819;GO:0042730;GO:0051604;GO:0080134;GO:0032102;GO:0008152;GO:0032101;GO:0044699;GO:0051241;GO:0051917;GO:0006508;GO:1903034;GO:1903035;GO:0051919;GO:0032501;GO:0050878;GO:0048518;GO:0016485;GO:0043170;GO:0050896;GO:0061041;GO:0061045;GO:0072376;GO:0072378;GO:0031639;GO:0031638;GO:0050789;GO:0071704;GO:0010467;GO:0044238; hemostasis;blood coagulation, intrinsic pathway;blood coagulation;regulation of response to stimulus;single-organism metabolic process;response to wounding;negative regulation of biological process;negative regulation of response to stimulus;single-multicellular organism process;response to external stimulus;protein metabolic process;regulation of blood coagulation;negative regulation of blood coagulation;regulation of hemostasis;negative regulation of hemostasis;biological regulation;regulation of biological quality;wound healing;response to stress;coagulation;biological_process;regulation of multicellular organismal process;regulation of coagulation;negative regulation of coagulation;fibrinolysis;protein maturation;regulation of response to stress;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;single-organism process;negative regulation of multicellular organismal process;regulation of fibrinolysis;proteolysis;regulation of response to wounding;negative regulation of response to wounding;positive regulation of fibrinolysis;multicellular organismal process;regulation of body fluid levels;positive regulation of biological process;protein processing;macromolecule metabolic process;response to stimulus;regulation of wound healing;negative regulation of wound healing;protein activation cascade;blood coagulation, fibrin clot formation;plasminogen activation;zymogen activation;regulation of biological process;organic substance metabolic process;gene expression;primary metabolic process; 5;4;5;3;3;4;2;3;3;3;4;5;5;4;4;2;3;5;3;4;1;3;4;4;6;5;4;4;2;4;2;3;6;5;5;4;3;2;4;2;6;4;2;6;5;3;4;8;7;2;3;5;3; GO:0031982;GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0043226;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0005886;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;organelle;cell part;cell;cell periphery;extracellular exosome;plasma membrane;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;2;3;2;3;2;2;2;3;4;3;3;3;1;2; GO:0004252;GO:0070009;GO:0017171;GO:0097367;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0005539;GO:0008238;GO:0008233;GO:0008236;GO:0043168;GO:0043167;GO:0070008;GO:0008201;GO:0004177;GO:0004175;GO:1901681;GO:0070011; serine-type endopeptidase activity;serine-type aminopeptidase activity;serine hydrolase activity;carbohydrate derivative binding;molecular_function;binding;hydrolase activity;catalytic activity;glycosaminoglycan binding;exopeptidase activity;peptidase activity;serine-type peptidase activity;anion binding;ion binding;serine-type exopeptidase activity;heparin binding;aminopeptidase activity;endopeptidase activity;sulfur compound binding;peptidase activity, acting on L-amino acid peptides; 6;7;4;3;1;2;3;2;4;6;4;5;4;3;6;4;7;6;3;5; K01323 map04610; Complement and coagulation cascades; IPR003609;IPR035696;IPR001254;IPR000177;IPR009003;IPR018114;IPR033116;IPR001314; PAN/Apple domain;Coagulation factor XI;Serine proteases, trypsin domain;Apple domain;Peptidase S1, PA clan;Serine proteases, trypsin family, histidine active site;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular Hs4503627 1305.0 E [E] Amino acid transport and metabolism; Q86W28 NACHT, LRR and PYD domains-containing protein 8 OS=Homo sapiens OX=9606 GN=NLRP8 PE=2 SV=2 - [NALP8_HUMAN] 0.956 1.23 0.876 1.152 1.013 1.114 0.777235772 nan 1.13721619 nan 0.712195122 nan 1.09970385 nan GO:0008219;GO:0070997;GO:0044699;GO:0009987;GO:0008150;GO:0044763; cell death;neuron death;single-organism process;cellular process;biological_process;single-organism cellular process; 4;5;2;2;1;3; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0035639;GO:0003674;GO:0005488;GO:0001883;GO:0000166;GO:1901363;GO:1901265;GO:0001882;GO:0043167;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0036094;GO:0032555;GO:0030554;GO:0097367;GO:0097159;GO:0032559;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;purine nucleoside binding;nucleotide binding;heterocyclic compound binding;nucleoside phosphate binding;nucleoside binding;ion binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;small molecule binding;purine ribonucleotide binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;5;4;3;4;4;3;5;5;6;4;3;5;6;3;3;6;6;4; K22662 IPR007111;IPR001611;IPR004020;IPR027417;IPR011029; NACHT nucleoside triphosphatase;Leucine-rich repeat;DAPIN domain;P-loop containing nucleoside triphosphate hydrolase;Death-like domain; plasma membrane 46446604 85.1 K [K] Transcription; COG4886 Leucine-rich repeat (LRR) protein Q8IZJ1 Netrin receptor UNC5B OS=Homo sapiens OX=9606 GN=UNC5B PE=1 SV=2 - [UNC5B_HUMAN] 0.834 0.911 1.391 0.922 0.898 1.523 0.915477497 nan 1.026726058 nan 1.526893524 nan 1.695991091 nan GO:2001234;GO:2001236;GO:2001237;GO:2001233;GO:0048585;GO:0048584;GO:0048583;GO:2001239;GO:0072359;GO:0043523;GO:0043524;GO:0007165;GO:0007166;GO:0071840;GO:0051716;GO:0042330;GO:0009966;GO:0048869;GO:0048514;GO:0048518;GO:0048519;GO:0006935;GO:0048468;GO:0097485;GO:0044700;GO:0009605;GO:0044707;GO:0072358;GO:0023051;GO:0006928;GO:0031175;GO:0035556;GO:0042981;GO:0050789;GO:0000904;GO:0000902;GO:0070997;GO:0001568;GO:0016043;GO:0065007;GO:0044699;GO:0048646;GO:0061564;GO:0050794;GO:0012501;GO:0008150;GO:1902533;GO:1901214;GO:1901215;GO:0048015;GO:0048017;GO:0009968;GO:0050896;GO:0048812;GO:0009967;GO:1901099;GO:0030154;GO:0023056;GO:0023057;GO:0023052;GO:0010648;GO:0007154;GO:0007411;GO:0010647;GO:0009653;GO:1902531;GO:0001944;GO:0033564;GO:2001240;GO:0032502;GO:0032501;GO:0038034;GO:0009987;GO:0014068;GO:0007409;GO:0014065;GO:0014066;GO:0048858;GO:0048731;GO:0030030;GO:0097190;GO:0097191;GO:0097192;GO:0008219;GO:0010941;GO:0007275;GO:0001525;GO:0010646;GO:0032989;GO:0043067;GO:0043066;GO:0060548;GO:0043069;GO:0048666;GO:0048667;GO:0030182;GO:0006915;GO:0044767;GO:0051402;GO:0044763;GO:0042221;GO:0022008;GO:0040011;GO:0048699;GO:0032990;GO:0007399;GO:0048856;GO:0048523;GO:0048522; negative regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of extrinsic apoptotic signaling pathway in absence of ligand;circulatory system development;regulation of neuron apoptotic process;negative regulation of neuron apoptotic process;signal transduction;cell surface receptor signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;taxis;regulation of signal transduction;cellular developmental process;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;chemotaxis;cell development;neuron projection guidance;single organism signaling;response to external stimulus;single-multicellular organism process;cardiovascular system development;regulation of signaling;movement of cell or subcellular component;neuron projection development;intracellular signal transduction;regulation of apoptotic process;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;neuron death;blood vessel development;cellular component organization;biological regulation;single-organism process;anatomical structure formation involved in morphogenesis;axon development;regulation of cellular process;programmed cell death;biological_process;positive regulation of intracellular signal transduction;regulation of neuron death;negative regulation of neuron death;phosphatidylinositol-mediated signaling;inositol lipid-mediated signaling;negative regulation of signal transduction;response to stimulus;neuron projection morphogenesis;positive regulation of signal transduction;negative regulation of signal transduction in absence of ligand;cell differentiation;positive regulation of signaling;negative regulation of signaling;signaling;negative regulation of cell communication;cell communication;axon guidance;positive regulation of cell communication;anatomical structure morphogenesis;regulation of intracellular signal transduction;vasculature development;anterior/posterior axon guidance;negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;developmental process;multicellular organismal process;signal transduction in absence of ligand;cellular process;positive regulation of phosphatidylinositol 3-kinase signaling;axonogenesis;phosphatidylinositol 3-kinase signaling;regulation of phosphatidylinositol 3-kinase signaling;cell projection morphogenesis;system development;cell projection organization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;extrinsic apoptotic signaling pathway in absence of ligand;cell death;regulation of cell death;multicellular organism development;angiogenesis;regulation of cell communication;cellular component morphogenesis;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of programmed cell death;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;apoptotic process;single-organism developmental process;neuron apoptotic process;single-organism cellular process;response to chemical;neurogenesis;locomotion;generation of neurons;cell part morphogenesis;nervous system development;anatomical structure development;negative regulation of cellular process;positive regulation of cellular process; 5;6;6;5;3;3;3;7;5;6;6;4;5;2;3;3;4;4;4;2;2;4;4;5;3;3;3;5;3;4;5;5;6;2;5;5;5;4;3;2;2;3;6;3;5;1;5;5;5;7;6;4;2;6;4;5;5;3;3;2;4;4;6;4;3;5;5;7;6;2;2;5;2;6;7;8;6;5;4;4;5;6;6;4;4;4;4;4;4;5;6;4;5;5;6;6;6;3;6;3;3;6;2;7;5;5;3;3;3; GO:0016021;GO:0016020;GO:0098589;GO:0044425;GO:0098857;GO:0031224;GO:0044464;GO:0005623;GO:0045121;GO:0071944;GO:0098805;GO:0005886;GO:0005575; integral component of membrane;membrane;membrane region;membrane part;membrane microdomain;intrinsic component of membrane;cell part;cell;membrane raft;cell periphery;whole membrane;plasma membrane;cellular_component; 4;2;3;2;4;3;2;2;5;3;3;3;1; K07521 map04360; Axon guidance; IPR003599;IPR003598;IPR013783;IPR033772;IPR000884;IPR007110;IPR000906;IPR000488;IPR011029;IPR013098; Immunoglobulin subtype;Immunoglobulin subtype 2;Immunoglobulin-like fold;UPA domain;Thrombospondin type-1 (TSP1) repeat;Immunoglobulin-like domain;ZU5 domain;Death domain;Death-like domain;Immunoglobulin I-set; extracellular Hs16933525 1221.0 T [T] Signal transduction mechanisms; Q8NEY1 Neuron navigator 1 OS=Homo sapiens OX=9606 GN=NAV1 PE=1 SV=2 - [NAV1_HUMAN] 0.917 1.111 0.867 1.039 1.138 0.963 0.825382538 0.015785022 0.913005272 0.977524289 0.780378038 0.15981142 0.846221441 0.410244898 GO:0030154;GO:0006928;GO:0051674;GO:0001764;GO:0007275;GO:0044699;GO:0048869;GO:0016043;GO:0071840;GO:0016477;GO:0032502;GO:0040011;GO:0032501;GO:0009987;GO:0044767;GO:0008150;GO:0048731;GO:0022008;GO:0051179;GO:0006996;GO:0048699;GO:0007017;GO:0007010;GO:0007399;GO:0044707;GO:0048870;GO:0001578;GO:0048856;GO:0044763;GO:1902589;GO:0000226; cell differentiation;movement of cell or subcellular component;localization of cell;neuron migration;multicellular organism development;single-organism process;cellular developmental process;cellular component organization;cellular component organization or biogenesis;cell migration;developmental process;locomotion;multicellular organismal process;cellular process;single-organism developmental process;biological_process;system development;neurogenesis;localization;organelle organization;generation of neurons;microtubule-based process;cytoskeleton organization;nervous system development;single-multicellular organism process;cell motility;microtubule bundle formation;anatomical structure development;single-organism cellular process;single-organism organelle organization;microtubule cytoskeleton organization; 5;4;3;5;4;2;4;3;2;4;2;2;2;2;3;1;4;6;2;4;7;4;5;5;3;3;6;3;3;4;5; GO:0099512;GO:0099513;GO:0043232;GO:0043229;GO:0005874;GO:0005737;GO:0044446;GO:0043226;GO:0044430;GO:0005856;GO:0015630;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043228;GO:0044424;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;intracellular non-membrane-bounded organelle;intracellular organelle;microtubule;cytoplasm;intracellular organelle part;organelle;cytoskeletal part;cytoskeleton;microtubule cytoskeleton;cell part;cell;intracellular;cellular_component;non-membrane-bounded organelle;intracellular part;organelle part; 2;3;4;3;4;4;3;2;4;5;6;2;2;3;1;3;3;2; K16776 IPR003593;IPR027417; AAA+ ATPase domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs15421858 1182.0 Y [Y] Nuclear structure; P78316 Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3 - [NOP14_HUMAN] 0.741 0.695 2.05 0.703 0.845 0.471 1.06618705 0.239639173 0.831952663 0.051562013 2.949640288 0.000124734 0.55739645 0.015848417 GO:0000466;GO:0071840;GO:0034470;GO:0034471;GO:0000460;GO:0000462;GO:0000469;GO:0046483;GO:0000472;GO:0034660;GO:0000479;GO:0000478;GO:0044260;GO:0042254;GO:0006364;GO:0008150;GO:0008152;GO:0016070;GO:0016072;GO:0042274;GO:0000480;GO:0034641;GO:0006139;GO:0000967;GO:0000966;GO:0022613;GO:0009987;GO:0006725;GO:0090502;GO:0090501;GO:0030490;GO:0043170;GO:0006807;GO:0090304;GO:0090305;GO:1901360;GO:0071704;GO:0010467;GO:0000447;GO:0044238;GO:0044237;GO:0044085;GO:0006396; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);cellular component organization or biogenesis;ncRNA processing;ncRNA 5'-end processing;maturation of 5.8S rRNA;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);cleavage involved in rRNA processing;heterocycle metabolic process;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);ncRNA metabolic process;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);endonucleolytic cleavage involved in rRNA processing;cellular macromolecule metabolic process;ribosome biogenesis;rRNA processing;biological_process;metabolic process;RNA metabolic process;rRNA metabolic process;ribosomal small subunit biogenesis;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);cellular nitrogen compound metabolic process;nucleobase-containing compound metabolic process;rRNA 5'-end processing;RNA 5'-end processing;ribonucleoprotein complex biogenesis;cellular process;cellular aromatic compound metabolic process;RNA phosphodiester bond hydrolysis, endonucleolytic;RNA phosphodiester bond hydrolysis;maturation of SSU-rRNA;macromolecule metabolic process;nitrogen compound metabolic process;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;organic cyclic compound metabolic process;organic substance metabolic process;gene expression;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);primary metabolic process;cellular metabolic process;cellular component biogenesis;RNA processing; 8;2;7;8;7;7;7;4;8;6;8;7;4;5;6;1;2;5;7;5;8;4;4;7;7;4;2;4;7;6;6;4;3;5;6;4;3;5;8;3;3;3;6; GO:0031974;GO:0031981;GO:0016020;GO:0030692;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0030689;GO:0030688;GO:0044464;GO:0030686;GO:0030684;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0044446;GO:0044444;GO:0005737;GO:0005730;GO:0005634;GO:0005739;GO:1990904;GO:0005623;GO:0032040;GO:0030529;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;Noc4p-Nop14p complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;Noc complex;preribosome, small subunit precursor;cell part;90S preribosome;preribosome;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasmic part;cytoplasm;nucleolus;nucleus;mitochondrion;ribonucleoprotein complex;cell;small-subunit processome;intracellular ribonucleoprotein complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;2;5;3;4;4;3;4;3;2;4;6;2;6;5;3;3;3;3;2;3;4;4;5;5;5;3;2;6;4;2;1;4; GO:1901363;GO:0030515;GO:0003674;GO:0003676;GO:0097159;GO:0019899;GO:0044822;GO:0003723;GO:0005515;GO:0005488; heterocyclic compound binding;snoRNA binding;molecular_function;nucleic acid binding;organic cyclic compound binding;enzyme binding;poly(A) RNA binding;RNA binding;protein binding;binding; 3;6;1;4;3;4;6;5;3;2; K14766 IPR007276; Nucleolar protein 14; plasma membrane Hs14781076 1756.0 J [J] Translation, ribosomal structure and biogenesis; P02790 Hemopexin OS=Homo sapiens OX=9606 GN=HPX PE=1 SV=2 - [HEMO_HUMAN] 1.065 0.917 1.044 1.087 0.937 1.135 1.161395856 5.42E-101 1.160085379 3.08E-155 1.138495093 1.41E-70 1.2113127 3.53E-82 GO:0019220;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0006778;GO:0031349;GO:0002706;GO:0002705;GO:0055072;GO:0002703;GO:0007165;GO:0007166;GO:0055076;GO:0098771;GO:0002455;GO:1901360;GO:0002708;GO:0044710;GO:0042440;GO:0009967;GO:0018212;GO:0042531;GO:0018193;GO:0044419;GO:0048518;GO:0065007;GO:0046483;GO:0019725;GO:0042325;GO:0060255;GO:0002824;GO:0002822;GO:0002821;GO:0042221;GO:0050776;GO:1901564;GO:0010033;GO:0016192;GO:1901678;GO:0044700;GO:0042327;GO:0019538;GO:0050730;GO:0048878;GO:0002376;GO:0050731;GO:0007154;GO:0002702;GO:0060330;GO:0020027;GO:0006950;GO:0023051;GO:0002923;GO:0002922;GO:0006807;GO:0002925;GO:0035556;GO:0045088;GO:0044267;GO:0051186;GO:0046916;GO:0044260;GO:0002377;GO:0002684;GO:0033013;GO:0002891;GO:0001961;GO:0002700;GO:0065008;GO:0034097;GO:0006810;GO:0002714;GO:0051716;GO:0050794;GO:0006952;GO:0002889;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:1902533;GO:0051234;GO:0010604;GO:0060332;GO:0006897;GO:0060333;GO:0071345;GO:0050896;GO:0006898;GO:0002712;GO:0009966;GO:0016064;GO:0060760;GO:0002699;GO:0016310;GO:0050801;GO:0060335;GO:0001959;GO:0002819;GO:0023056;GO:0023052;GO:0060759;GO:0070887;GO:0010647;GO:0010646;GO:0044699;GO:0009893;GO:1902531;GO:0010562;GO:0051246;GO:0051247;GO:0007259;GO:0032270;GO:0031399;GO:0007260;GO:0042168;GO:0006879;GO:0071346;GO:0042508;GO:0006875;GO:0009987;GO:0006725;GO:0006873;GO:0002637;GO:0030003;GO:0055080;GO:0055082;GO:0031347;GO:0002639;GO:0032268;GO:0002460;GO:0015886;GO:0050778;GO:0043170;GO:0002920;GO:1904892;GO:0080134;GO:1904894;GO:0031401;GO:0019724;GO:0031325;GO:0031323;GO:0018108;GO:0042592;GO:0006959;GO:0002682;GO:0042510;GO:0042511;GO:0002697;GO:0002443;GO:0050789;GO:0071705;GO:0071704;GO:0071310;GO:0097696;GO:0071702;GO:0051704;GO:0019221;GO:0006468;GO:0045089;GO:0046427;GO:0045937;GO:0046425;GO:0045087;GO:0002252;GO:0006464;GO:0034341;GO:0051174;GO:0002449;GO:0044765;GO:0044764;GO:0044763;GO:0060334;GO:0055065;GO:0002440;GO:0051181;GO:0051179;GO:1902578;GO:0042509;GO:0044238;GO:0044237;GO:0006796;GO:0002250;GO:0016032;GO:0006793;GO:0044403;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;porphyrin-containing compound metabolic process;positive regulation of defense response;regulation of lymphocyte mediated immunity;positive regulation of leukocyte mediated immunity;iron ion homeostasis;regulation of leukocyte mediated immunity;signal transduction;cell surface receptor signaling pathway;transition metal ion homeostasis;inorganic ion homeostasis;humoral immune response mediated by circulating immunoglobulin;organic cyclic compound metabolic process;positive regulation of lymphocyte mediated immunity;single-organism metabolic process;pigment metabolic process;positive regulation of signal transduction;peptidyl-tyrosine modification;positive regulation of tyrosine phosphorylation of STAT protein;peptidyl-amino acid modification;interspecies interaction between organisms;positive regulation of biological process;biological regulation;heterocycle metabolic process;cellular homeostasis;regulation of phosphorylation;regulation of macromolecule metabolic process;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of adaptive immune response;response to chemical;regulation of immune response;organonitrogen compound metabolic process;response to organic substance;vesicle-mediated transport;iron coordination entity transport;single organism signaling;positive regulation of phosphorylation;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;chemical homeostasis;immune system process;positive regulation of peptidyl-tyrosine phosphorylation;cell communication;positive regulation of production of molecular mediator of immune response;regulation of response to interferon-gamma;hemoglobin metabolic process;response to stress;regulation of signaling;regulation of humoral immune response mediated by circulating immunoglobulin;positive regulation of humoral immune response;nitrogen compound metabolic process;positive regulation of humoral immune response mediated by circulating immunoglobulin;intracellular signal transduction;regulation of innate immune response;cellular protein metabolic process;cofactor metabolic process;cellular transition metal ion homeostasis;cellular macromolecule metabolic process;immunoglobulin production;positive regulation of immune system process;tetrapyrrole metabolic process;positive regulation of immunoglobulin mediated immune response;positive regulation of cytokine-mediated signaling pathway;regulation of production of molecular mediator of immune response;regulation of biological quality;response to cytokine;transport;positive regulation of B cell mediated immunity;cellular response to stimulus;regulation of cellular process;defense response;regulation of immunoglobulin mediated immune response;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;positive regulation of intracellular signal transduction;establishment of localization;positive regulation of macromolecule metabolic process;positive regulation of response to interferon-gamma;endocytosis;interferon-gamma-mediated signaling pathway;cellular response to cytokine stimulus;response to stimulus;receptor-mediated endocytosis;regulation of B cell mediated immunity;regulation of signal transduction;immunoglobulin mediated immune response;positive regulation of response to cytokine stimulus;positive regulation of immune effector process;phosphorylation;ion homeostasis;positive regulation of interferon-gamma-mediated signaling pathway;regulation of cytokine-mediated signaling pathway;regulation of adaptive immune response;positive regulation of signaling;signaling;regulation of response to cytokine stimulus;cellular response to chemical stimulus;positive regulation of cell communication;regulation of cell communication;single-organism process;positive regulation of metabolic process;regulation of intracellular signal transduction;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;JAK-STAT cascade;positive regulation of cellular protein metabolic process;regulation of protein modification process;tyrosine phosphorylation of STAT protein;heme metabolic process;cellular iron ion homeostasis;cellular response to interferon-gamma;tyrosine phosphorylation of Stat1 protein;cellular metal ion homeostasis;cellular process;cellular aromatic compound metabolic process;cellular ion homeostasis;regulation of immunoglobulin production;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of defense response;positive regulation of immunoglobulin production;regulation of cellular protein metabolic process;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;heme transport;positive regulation of immune response;macromolecule metabolic process;regulation of humoral immune response;regulation of STAT cascade;regulation of response to stress;positive regulation of STAT cascade;positive regulation of protein modification process;B cell mediated immunity;positive regulation of cellular metabolic process;regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;homeostatic process;humoral immune response;regulation of immune system process;regulation of tyrosine phosphorylation of Stat1 protein;positive regulation of tyrosine phosphorylation of Stat1 protein;regulation of immune effector process;leukocyte mediated immunity;regulation of biological process;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;STAT cascade;organic substance transport;multi-organism process;cytokine-mediated signaling pathway;protein phosphorylation;positive regulation of innate immune response;positive regulation of JAK-STAT cascade;positive regulation of phosphate metabolic process;regulation of JAK-STAT cascade;innate immune response;immune effector process;cellular protein modification process;response to interferon-gamma;regulation of phosphorus metabolic process;lymphocyte mediated immunity;single-organism transport;multi-organism cellular process;single-organism cellular process;regulation of interferon-gamma-mediated signaling pathway;metal ion homeostasis;production of molecular mediator of immune response;cofactor transport;localization;single-organism localization;regulation of tyrosine phosphorylation of STAT protein;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;adaptive immune response;viral process;phosphorus metabolic process;symbiosis, encompassing mutualism through parasitism;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;4;3;3;3;5;4;6;5;10;5;4;5;9;7;5;4;6;3;4;4;8;8;7;3;2;2;4;4;7;4;6;6;5;3;4;4;4;5;5;3;7;4;8;5;2;8;4;4;5;5;3;3;6;5;3;6;5;5;5;4;9;4;4;3;5;8;5;4;3;5;4;7;3;3;4;8;5;5;1;2;3;5;3;4;5;6;7;6;2;7;7;4;7;4;4;6;6;6;5;5;3;2;4;4;4;4;2;3;5;5;5;5;7;5;6;8;4;10;6;9;8;2;4;6;5;7;7;5;5;5;5;5;6;4;4;5;6;4;6;6;6;4;4;8;4;4;3;9;9;4;4;2;5;3;5;6;5;2;6;7;5;7;6;7;4;3;6;5;5;5;4;3;3;6;8;3;5;2;3;8;3;3;5;4;4;4;4;7;7;3; GO:0031982;GO:0071682;GO:0016023;GO:0031988;GO:0031974;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0072562;GO:0044433;GO:0097708;GO:0031983;GO:0044446;GO:0044444;GO:0060205;GO:0005737;GO:0031410;GO:0030139;GO:0044464;GO:0005623;GO:0005615;GO:1903561;GO:0070062;GO:0005575;GO:0005576; vesicle;endocytic vesicle lumen;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;membrane-enclosed lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;blood microparticle;cytoplasmic vesicle part;intracellular vesicle;vesicle lumen;intracellular organelle part;cytoplasmic part;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;cytoplasmic vesicle;endocytic vesicle;cell part;cell;extracellular space;extracellular vesicle;extracellular exosome;cellular_component;extracellular region; 4;6;5;5;2;3;4;3;3;2;2;3;3;3;2;3;4;4;4;3;4;5;4;5;6;2;2;3;3;4;1;2; GO:0003674;GO:0005488;GO:0046872;GO:0043169;GO:0051184;GO:0005215;GO:0015232;GO:0043167; molecular_function;binding;metal ion binding;cation binding;cofactor transporter activity;transporter activity;heme transporter activity;ion binding; 1;2;5;4;3;2;4;3; K18977 IPR018487;IPR018486;IPR000585;IPR016358; Hemopexin-like repeats;Hemopexin, conserved site;Hemopexin-like domain;Hemopexin; extracellular Hs11321561 959.0 OW [O] Posttranslational modification, protein turnover, chaperones;[W] Extracellular structures; P01762 Immunoglobulin heavy variable 3-11 OS=Homo sapiens OX=9606 GN=IGHV3-11 PE=1 SV=2 - [HV311_HUMAN] 1.14 0.956 0.796 0.903 1.232 1.374 1.192468619 0.036975479 0.732954545 0.385866167 0.832635983 0.038630342 1.11525974 0.700980431 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P01764 Immunoglobulin heavy variable 3-23 OS=Homo sapiens OX=9606 GN=IGHV3-23 PE=1 SV=2 - [HV323_HUMAN] 0.976 1.119 0.768 0.956 1.25 0.785 0.872207328 0.028990954 0.7648 1.27E-05 0.686327078 5.93E-06 0.628 0.987073573 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0048518;GO:0002682;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0050789;GO:0002764;GO:0002431;GO:0002768;GO:0002433;GO:0016043;GO:0002684;GO:0065007;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0038096;GO:0038094;GO:0038095;GO:0006897;GO:0038093;GO:0050896;GO:0006898;GO:0001775;GO:0042742;GO:0002694;GO:0002696;GO:0006956;GO:0009617;GO:0023052;GO:0044699;GO:0051234;GO:0008037;GO:0009987;GO:0050871;GO:0002757;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0072376;GO:0002443;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;cellular component organization;positive regulation of immune system process;biological regulation;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;complement activation, classical pathway;humoral immune response;Fc-gamma receptor signaling pathway involved in phagocytosis;Fc-gamma receptor signaling pathway;Fc-epsilon receptor signaling pathway;endocytosis;Fc receptor signaling pathway;response to stimulus;receptor-mediated endocytosis;cell activation;defense response to bacterium;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;response to bacterium;signaling;single-organism process;establishment of localization;cell recognition;cellular process;positive regulation of B cell activation;immune response-activating signal transduction;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;2;3;6;4;3;3;2;3;5;5;3;4;2;3;2;5;6;6;4;3;3;2;4;3;3;4;3;7;1;2;3;5;4;5;8;8;6;7;2;7;4;5;4;4;4;4;2;2;3;4;2;6;4;4;4;5;5;4;5;4;4;6;4;5;3;4;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;5;3; GO:0031982;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0005623;GO:0043227;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;cell;membrane-bounded organelle;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;2;3;3;2;2;4;2;3;3;4;3;3;2;3;3;3;2;3;3;4;2;1;2;3; GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102;GO:0005488; molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding;binding; 1;5;3;3;4;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q9P2M4 TBC1 domain family member 14 OS=Homo sapiens OX=9606 GN=TBC1D14 PE=1 SV=3 - [TBC14_HUMAN] 0.749 1.134 1.333 0.769 1.117 0.987 0.660493827 0.024718517 0.688451209 0.020261855 1.175485009 0.16106909 0.883616831 0.240979467 GO:0019222;GO:0048583;GO:0071840;GO:0051716;GO:0033043;GO:1905037;GO:0048519;GO:0016197;GO:0016192;GO:0009605;GO:0031667;GO:0033554;GO:0009894;GO:0022607;GO:0009892;GO:0016043;GO:0065007;GO:0006914;GO:0006810;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0051234;GO:0046907;GO:0050896;GO:0080135;GO:0032107;GO:0032104;GO:0042147;GO:0032101;GO:0051128;GO:0044248;GO:0009895;GO:0010646;GO:0044699;GO:0000045;GO:0031330;GO:0031323;GO:0009987;GO:0071955;GO:0016482;GO:2000785;GO:0007033;GO:0007034;GO:0080134;GO:0009991;GO:0031329;GO:0031324;GO:0016236;GO:0050789;GO:1902115;GO:0010506;GO:0010507;GO:0016241;GO:0048193;GO:0044765;GO:0044763;GO:0051649;GO:0007154;GO:0070925;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044237;GO:0044087;GO:0044085;GO:0048523;GO:1902582;GO:0044088; regulation of metabolic process;regulation of response to stimulus;cellular component organization or biogenesis;cellular response to stimulus;regulation of organelle organization;autophagosome organization;negative regulation of biological process;endosomal transport;vesicle-mediated transport;response to external stimulus;response to nutrient levels;cellular response to stress;regulation of catabolic process;cellular component assembly;negative regulation of metabolic process;cellular component organization;biological regulation;autophagy;transport;regulation of cellular process;response to stress;biological_process;metabolic process;establishment of localization;intracellular transport;response to stimulus;regulation of cellular response to stress;regulation of response to nutrient levels;regulation of response to extracellular stimulus;retrograde transport, endosome to Golgi;regulation of response to external stimulus;regulation of cellular component organization;cellular catabolic process;negative regulation of catabolic process;regulation of cell communication;single-organism process;autophagosome assembly;negative regulation of cellular catabolic process;regulation of cellular metabolic process;cellular process;recycling endosome to Golgi transport;cytosolic transport;regulation of autophagosome assembly;vacuole organization;vacuolar transport;regulation of response to stress;response to extracellular stimulus;regulation of cellular catabolic process;negative regulation of cellular metabolic process;macroautophagy;regulation of biological process;regulation of organelle assembly;regulation of autophagy;negative regulation of autophagy;regulation of macroautophagy;Golgi vesicle transport;single-organism transport;single-organism cellular process;establishment of localization in cell;cell communication;organelle assembly;catabolic process;localization;single-organism localization;cellular localization;organelle organization;cellular metabolic process;regulation of cellular component biogenesis;cellular component biogenesis;negative regulation of cellular process;single-organism intracellular transport;regulation of vacuole organization; 3;3;2;3;5;5;2;7;5;3;5;4;4;4;3;3;2;3;4;3;3;1;2;3;5;2;4;6;5;6;4;4;4;4;4;2;6;5;4;2;7;6;5;5;6;4;4;5;4;4;2;4;4;4;5;6;4;3;4;4;5;3;2;3;3;4;3;3;3;3;5;6; GO:0005773;GO:0005776;GO:0005794;GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0044444;GO:0055037;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005768; vacuole;autophagosome;Golgi apparatus;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;cytoplasmic part;recycling endosome;cytoplasm;cell part;cell;intracellular;cellular_component;endosome; 5;6;4;4;3;3;3;2;3;4;5;4;2;2;3;1;4; GO:0098772;GO:0005096;GO:0019901;GO:0030695;GO:0003674;GO:0005488;GO:0019899;GO:0060589;GO:0005515;GO:0008047;GO:0030234;GO:0019900; molecular function regulator;GTPase activator activity;protein kinase binding;GTPase regulator activity;molecular_function;binding;enzyme binding;nucleoside-triphosphatase regulator activity;protein binding;enzyme activator activity;enzyme regulator activity;kinase binding; 2;5;6;5;1;2;4;4;3;4;3;5; K20167 IPR000195; Rab-GTPase-TBC domain; cytosol Hs14733591 1435.0 TR [T] Signal transduction mechanisms;[R] General function prediction only; P01766 Immunoglobulin heavy variable 3-13 OS=Homo sapiens OX=9606 GN=IGHV3-13 PE=1 SV=2 - [HV313_HUMAN] 1.146 0.926 0.952 0.946 0.96 1.309 1.237580994 0.355673115 0.985416667 0.303722654 1.028077754 0.189737529 1.363541667 0.102323432 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q15582 Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1 - [BGH3_HUMAN] 0.85 1.226 0.846 0.934 1.192 1.288 0.693311582 0.287681313 0.783557047 0.485153956 0.69004894 0.894529243 1.080536913 0.476644042 GO:0001501;GO:0007162;GO:0072358;GO:0071840;GO:0048869;GO:0048513;GO:0048514;GO:0002062;GO:0048519;GO:0007601;GO:0007600;GO:0003008;GO:0051216;GO:0044707;GO:0019538;GO:0072359;GO:0030198;GO:0043170;GO:0050789;GO:0044267;GO:0044260;GO:0001568;GO:0016043;GO:0065007;GO:0048646;GO:0009888;GO:0050953;GO:0050794;GO:0008150;GO:0008152;GO:0050896;GO:0030155;GO:0030154;GO:0009653;GO:0044699;GO:0001944;GO:0022610;GO:0032502;GO:0032501;GO:0008283;GO:0050877;GO:0009987;GO:0048731;GO:0001525;GO:0007275;GO:0071704;GO:0043062;GO:0061448;GO:0044767;GO:0044763;GO:0007155;GO:0044238;GO:0048856;GO:0044237;GO:0048523; skeletal system development;negative regulation of cell adhesion;cardiovascular system development;cellular component organization or biogenesis;cellular developmental process;animal organ development;blood vessel morphogenesis;chondrocyte differentiation;negative regulation of biological process;visual perception;sensory perception;system process;cartilage development;single-multicellular organism process;protein metabolic process;circulatory system development;extracellular matrix organization;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;blood vessel development;cellular component organization;biological regulation;anatomical structure formation involved in morphogenesis;tissue development;sensory perception of light stimulus;regulation of cellular process;biological_process;metabolic process;response to stimulus;regulation of cell adhesion;cell differentiation;anatomical structure morphogenesis;single-organism process;vasculature development;biological adhesion;developmental process;multicellular organismal process;cell proliferation;neurological system process;cellular process;system development;angiogenesis;multicellular organism development;organic substance metabolic process;extracellular structure organization;connective tissue development;single-organism developmental process;single-organism cellular process;cell adhesion;primary metabolic process;anatomical structure development;cellular metabolic process;negative regulation of cellular process; 5;4;5;2;4;4;4;6;2;7;5;3;5;3;4;5;5;4;2;5;4;4;3;2;3;4;6;3;1;2;2;4;5;3;2;5;2;2;2;3;4;2;4;4;4;3;4;5;3;3;3;3;3;3;3; GO:0031984;GO:0031982;GO:0016020;GO:0005794;GO:0043230;GO:0043231;GO:0044424;GO:0044420;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0031012;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005802;GO:0071944;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0005604;GO:0005575;GO:0005576;GO:0098791;GO:0005578; organelle subcompartment;vesicle;membrane;Golgi apparatus;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular matrix component;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;extracellular matrix;cytoplasm;cell part;cell;intracellular;trans-Golgi network;cell periphery;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;basement membrane;cellular_component;extracellular region;Golgi subcompartment;proteinaceous extracellular matrix; 4;4;2;4;3;4;3;2;2;2;3;3;4;3;3;4;2;4;2;2;3;5;3;3;2;3;3;4;3;1;2;5;3; GO:0050840;GO:0050839;GO:0044877;GO:0005488;GO:0032403;GO:0005515;GO:0005102;GO:0005518;GO:0003674;GO:0005178; extracellular matrix binding;cell adhesion molecule binding;macromolecular complex binding;binding;protein complex binding;protein binding;receptor binding;collagen binding;molecular_function;integrin binding; 3;4;3;2;4;3;4;5;1;5; K19519 IPR011489;IPR016666;IPR032954;IPR000782; EMI domain;TGF beta-induced protein/periostin;Transforming growth factor-beta-induced protein ig-h3;FAS1 domain; extracellular Hs4507467 1405.0 MW [M] Cell wall/membrane/envelope biogenesis;[W] Extracellular structures; Q8NI38 NF-kappa-B inhibitor delta OS=Homo sapiens OX=9606 GN=NFKBID PE=1 SV=1 - [IKBD_HUMAN] 0.903 0.691 0.95 0.926 0.803 4.177 1.306801737 nan 1.153175592 nan 1.374819103 nan 5.201743462 nan GO:0080090;GO:0034111;GO:0034110;GO:0070232;GO:0033081;GO:0048585;GO:0070231;GO:0048583;GO:0033085;GO:0070234;GO:0007162;GO:0007165;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0019222;GO:0009968;GO:0009966;GO:0048869;GO:0043433;GO:0048513;GO:0044092;GO:0043124;GO:0002682;GO:0070245;GO:0070243;GO:0070230;GO:0043122;GO:0070228;GO:0030217;GO:0060255;GO:0006366;GO:0070227;GO:0046649;GO:2001141;GO:1903706;GO:1903707;GO:0046483;GO:0044700;GO:0044707;GO:0044249;GO:0043068;GO:0002376;GO:0019438;GO:0070489;GO:0009892;GO:0009890;GO:0007249;GO:0008152;GO:0045321;GO:0006807;GO:0035556;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:2000398;GO:2000399;GO:0098609;GO:0065007;GO:0002683;GO:1902532;GO:0065009;GO:0071593;GO:0071594;GO:0018130;GO:0043067;GO:0098602;GO:0033077;GO:0050793;GO:0009889;GO:0050794;GO:0006952;GO:0012501;GO:0001775;GO:0008150;GO:0051239;GO:0030097;GO:0034654;GO:1902531;GO:0002521;GO:0002520;GO:0016070;GO:1902679;GO:0070242;GO:0044271;GO:0050896;GO:0006950;GO:0032088;GO:0002695;GO:0002694;GO:0010556;GO:0006351;GO:0048518;GO:0007159;GO:0010558;GO:0006954;GO:0031324;GO:0032774;GO:0030155;GO:0030154;GO:0045580;GO:0045581;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0044699;GO:0006139;GO:0051249;GO:0051241;GO:1903038;GO:0031327;GO:0045620;GO:0022610;GO:0071887;GO:1903037;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045596;GO:0045595;GO:0045892;GO:0042110;GO:0048519;GO:0051093;GO:0051090;GO:0051250;GO:0051253;GO:0051252;GO:0010629;GO:0045619;GO:0030098;GO:0048731;GO:2000106;GO:0016337;GO:0050868;GO:0050865;GO:0031326;GO:0050866;GO:0031323;GO:0050863;GO:0090304;GO:0022407;GO:0010942;GO:0008219;GO:0010941;GO:0007275;GO:0022408;GO:0006355;GO:0042981;GO:2000112;GO:2000113;GO:0050789;GO:0043065;GO:0071704;GO:0010467;GO:0006357;GO:0048534;GO:0010468;GO:0045934;GO:0019219;GO:0034109;GO:0006915;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007155;GO:0007154;GO:0070486;GO:0044238;GO:2000108;GO:0048856;GO:0044237;GO:1902106;GO:1902105;GO:2000026;GO:0023057;GO:0048523;GO:0048522; regulation of primary metabolic process;negative regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;regulation of T cell apoptotic process;regulation of T cell differentiation in thymus;negative regulation of response to stimulus;T cell apoptotic process;regulation of response to stimulus;negative regulation of T cell differentiation in thymus;positive regulation of T cell apoptotic process;negative regulation of cell adhesion;signal transduction;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;regulation of metabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;negative regulation of sequence-specific DNA binding transcription factor activity;animal organ development;negative regulation of molecular function;negative regulation of I-kappaB kinase/NF-kappaB signaling;regulation of immune system process;positive regulation of thymocyte apoptotic process;regulation of thymocyte apoptotic process;positive regulation of lymphocyte apoptotic process;regulation of I-kappaB kinase/NF-kappaB signaling;regulation of lymphocyte apoptotic process;T cell differentiation;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;lymphocyte apoptotic process;lymphocyte activation;regulation of RNA biosynthetic process;regulation of hemopoiesis;negative regulation of hemopoiesis;heterocycle metabolic process;single organism signaling;single-multicellular organism process;cellular biosynthetic process;positive regulation of programmed cell death;immune system process;aromatic compound biosynthetic process;T cell aggregation;negative regulation of metabolic process;negative regulation of biosynthetic process;I-kappaB kinase/NF-kappaB signaling;metabolic process;leukocyte activation;nitrogen compound metabolic process;intracellular signal transduction;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of thymocyte aggregation;negative regulation of thymocyte aggregation;cell-cell adhesion;biological regulation;negative regulation of immune system process;negative regulation of intracellular signal transduction;regulation of molecular function;lymphocyte aggregation;thymocyte aggregation;heterocycle biosynthetic process;regulation of programmed cell death;single organism cell adhesion;T cell differentiation in thymus;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;defense response;programmed cell death;cell activation;biological_process;regulation of multicellular organismal process;hemopoiesis;nucleobase-containing compound biosynthetic process;regulation of intracellular signal transduction;leukocyte differentiation;immune system development;RNA metabolic process;negative regulation of RNA biosynthetic process;thymocyte apoptotic process;cellular nitrogen compound biosynthetic process;response to stimulus;response to stress;negative regulation of NF-kappaB transcription factor activity;negative regulation of leukocyte activation;regulation of leukocyte activation;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of biological process;leukocyte cell-cell adhesion;negative regulation of macromolecule biosynthetic process;inflammatory response;negative regulation of cellular metabolic process;RNA biosynthetic process;regulation of cell adhesion;cell differentiation;regulation of T cell differentiation;negative regulation of T cell differentiation;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;single-organism process;nucleobase-containing compound metabolic process;regulation of lymphocyte activation;negative regulation of multicellular organismal process;negative regulation of leukocyte cell-cell adhesion;negative regulation of cellular biosynthetic process;negative regulation of lymphocyte differentiation;biological adhesion;leukocyte apoptotic process;regulation of leukocyte cell-cell adhesion;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;T cell activation;negative regulation of biological process;negative regulation of developmental process;regulation of sequence-specific DNA binding transcription factor activity;negative regulation of lymphocyte activation;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;regulation of lymphocyte differentiation;lymphocyte differentiation;system development;regulation of leukocyte apoptotic process;single organismal cell-cell adhesion;negative regulation of T cell activation;regulation of cell activation;regulation of cellular biosynthetic process;negative regulation of cell activation;regulation of cellular metabolic process;regulation of T cell activation;nucleic acid metabolic process;regulation of cell-cell adhesion;positive regulation of cell death;cell death;regulation of cell death;multicellular organism development;negative regulation of cell-cell adhesion;regulation of transcription, DNA-templated;regulation of apoptotic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;positive regulation of apoptotic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;hematopoietic or lymphoid organ development;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;homotypic cell-cell adhesion;apoptotic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell adhesion;cell communication;leukocyte aggregation;primary metabolic process;positive regulation of leukocyte apoptotic process;anatomical structure development;cellular metabolic process;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;negative regulation of signaling;negative regulation of cellular process;positive regulation of cellular process; 4;6;6;9;6;3;9;3;6;9;4;4;5;4;3;4;3;4;4;4;5;4;4;6;3;10;10;8;6;8;6;4;7;8;4;6;4;4;4;3;3;4;5;2;5;4;3;4;6;2;3;3;5;4;7;4;4;5;5;4;2;3;5;3;7;5;5;5;3;6;3;4;3;4;5;4;1;3;5;5;5;6;3;5;6;10;5;2;3;6;4;4;5;6;2;5;5;5;4;6;4;5;7;7;4;2;4;5;3;4;2;4;5;3;6;5;6;2;7;6;2;2;2;4;7;7;4;4;6;5;2;3;4;5;5;5;5;6;5;4;7;4;6;4;5;4;4;6;5;5;4;4;4;4;5;6;6;6;6;2;6;3;5;7;4;5;5;5;5;6;3;3;5;3;4;4;3;4;6;3;7;3;3;5;5;4;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;organelle;nucleus;cell part;cell;intracellular;cellular_component; 4;3;3;3;2;5;2;2;3;1; GO:0003712;GO:0003674;GO:0000989;GO:0000988; transcription cofactor activity;molecular_function;transcription factor activity, transcription factor binding;transcription factor activity, protein binding; 4;1;3;2; K14214 IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; mitochondria Hs21245100 617.0 R [R] General function prediction only; P24592 Insulin-like growth factor-binding protein 6 OS=Homo sapiens OX=9606 GN=IGFBP6 PE=1 SV=1 - [IBP6_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0042127;GO:0008285;GO:0044237;GO:0048585;GO:0007167;GO:0048583;GO:0051128;GO:0023057;GO:0030111;GO:0048009;GO:0023052;GO:0007165;GO:0007166;GO:0023051;GO:0071840;GO:0007169;GO:0010646;GO:0050789;GO:0044699;GO:0044267;GO:0051716;GO:0043567;GO:0016049;GO:0009968;GO:0009966;GO:0040008;GO:0008283;GO:0016043;GO:0030178;GO:0071704;GO:0065007;GO:0040007;GO:0048519;GO:0090090;GO:0043170;GO:0044238;GO:0044260;GO:0009987;GO:0050794;GO:0060070;GO:0001558;GO:0008150;GO:0008152;GO:0007154;GO:0044700;GO:0019538;GO:0050896;GO:0016055;GO:0048523;GO:0044763;GO:0060828;GO:0010648; regulation of cell proliferation;negative regulation of cell proliferation;cellular metabolic process;negative regulation of response to stimulus;enzyme linked receptor protein signaling pathway;regulation of response to stimulus;regulation of cellular component organization;negative regulation of signaling;regulation of Wnt signaling pathway;insulin-like growth factor receptor signaling pathway;signaling;signal transduction;cell surface receptor signaling pathway;regulation of signaling;cellular component organization or biogenesis;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of cell communication;regulation of biological process;single-organism process;cellular protein metabolic process;cellular response to stimulus;regulation of insulin-like growth factor receptor signaling pathway;cell growth;negative regulation of signal transduction;regulation of signal transduction;regulation of growth;cell proliferation;cellular component organization;negative regulation of Wnt signaling pathway;organic substance metabolic process;biological regulation;growth;negative regulation of biological process;negative regulation of canonical Wnt signaling pathway;macromolecule metabolic process;primary metabolic process;cellular macromolecule metabolic process;cellular process;regulation of cellular process;canonical Wnt signaling pathway;regulation of cell growth;biological_process;metabolic process;cell communication;single organism signaling;protein metabolic process;response to stimulus;Wnt signaling pathway;negative regulation of cellular process;single-organism cellular process;regulation of canonical Wnt signaling pathway;negative regulation of cell communication; 4;4;3;3;6;3;4;3;5;8;2;4;5;3;2;7;4;2;2;5;3;5;3;4;4;3;3;3;5;3;2;2;2;6;4;3;4;2;3;7;4;1;2;4;3;4;2;6;3;3;6;4; GO:0043226;GO:0043227;GO:0005737;GO:0005615;GO:0005794;GO:0070062;GO:0031982;GO:0012505;GO:1903561;GO:0043231;GO:0043230;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421; organelle;membrane-bounded organelle;cytoplasm;extracellular space;Golgi apparatus;extracellular exosome;vesicle;endomembrane system;extracellular vesicle;intracellular membrane-bounded organelle;extracellular organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part; 2;3;4;3;4;4;4;3;3;4;3;2;3;2;3;1;4;2;3;2; GO:0005488;GO:0003674;GO:0019838;GO:0005520;GO:0031995;GO:0031994;GO:0005515;GO:0005102; binding;molecular_function;growth factor binding;insulin-like growth factor binding;insulin-like growth factor II binding;insulin-like growth factor I binding;protein binding;receptor binding; 2;1;4;5;6;6;3;4; K23579 IPR022326;IPR009168;IPR022321;IPR000716;IPR009030;IPR000867; Insulin-like growth factor-binding protein 6;Insulin-like growth factor binding protein;Insulin-like growth factor-binding protein family 1-6, chordata;Thyroglobulin type-1;Growth factor receptor cysteine-rich domain;Insulin-like growth factor-binding protein, IGFBP; extracellular Q9Y2K9 Syntaxin-binding protein 5-like OS=Homo sapiens OX=9606 GN=STXBP5L PE=1 SV=2 - [STB5L_HUMAN] 0.998 0.986 1.095 1.136 1.059 0.881 1.012170385 0.547649552 1.072710104 0.19972606 1.110547667 0.801090284 0.831916903 0.005846532 GO:0090087;GO:0008104;GO:0051046;GO:0051047;GO:0051048;GO:0051049;GO:0046879;GO:0044093;GO:0048518;GO:0048519;GO:0033036;GO:0051050;GO:0045184;GO:0090276;GO:0023052;GO:0090278;GO:0050794;GO:0044700;GO:0016192;GO:0048878;GO:0046676;GO:0023051;GO:0032940;GO:0051222;GO:0051223;GO:0030072;GO:0030073;GO:0010646;GO:0050708;GO:0043547;GO:0051345;GO:0006887;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0070201;GO:0050790;GO:0009306;GO:0006810;GO:0050796;GO:0050709;GO:0008150;GO:0051234;GO:0051336;GO:0046903;GO:0050714;GO:0023057;GO:0015833;GO:1903531;GO:1903530;GO:1903532;GO:1904950;GO:1904951;GO:0043087;GO:0044699;GO:0032880;GO:0042886;GO:0017157;GO:0009987;GO:0060627;GO:0046883;GO:0046888;GO:0032879;GO:0060341;GO:0042592;GO:0042593;GO:0051051;GO:0051224;GO:0033500;GO:0050789;GO:0071705;GO:0071702;GO:0023061;GO:0010817;GO:0044765;GO:0044763;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0002790;GO:0002791;GO:0002792;GO:0009914;GO:0010648;GO:0015031;GO:0048523;GO:0048522; regulation of peptide transport;protein localization;regulation of secretion;positive regulation of secretion;negative regulation of secretion;regulation of transport;hormone secretion;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;macromolecule localization;positive regulation of transport;establishment of protein localization;regulation of peptide hormone secretion;signaling;negative regulation of peptide hormone secretion;regulation of cellular process;single organism signaling;vesicle-mediated transport;chemical homeostasis;negative regulation of insulin secretion;regulation of signaling;secretion by cell;positive regulation of protein transport;regulation of protein transport;peptide hormone secretion;insulin secretion;regulation of cell communication;regulation of protein secretion;positive regulation of GTPase activity;positive regulation of hydrolase activity;exocytosis;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;regulation of establishment of protein localization;regulation of catalytic activity;protein secretion;transport;regulation of insulin secretion;negative regulation of protein secretion;biological_process;establishment of localization;regulation of hydrolase activity;secretion;positive regulation of protein secretion;negative regulation of signaling;peptide transport;negative regulation of secretion by cell;regulation of secretion by cell;positive regulation of secretion by cell;negative regulation of establishment of protein localization;positive regulation of establishment of protein localization;regulation of GTPase activity;single-organism process;regulation of protein localization;amide transport;regulation of exocytosis;cellular process;regulation of vesicle-mediated transport;regulation of hormone secretion;negative regulation of hormone secretion;regulation of localization;regulation of cellular localization;homeostatic process;glucose homeostasis;negative regulation of transport;negative regulation of protein transport;carbohydrate homeostasis;regulation of biological process;nitrogen compound transport;organic substance transport;signal release;regulation of hormone levels;single-organism transport;single-organism cellular process;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;peptide secretion;regulation of peptide secretion;negative regulation of peptide secretion;hormone transport;negative regulation of cell communication;protein transport;negative regulation of cellular process;positive regulation of cellular process; 5;4;5;4;4;4;6;4;2;2;3;3;4;5;2;5;3;3;5;5;6;3;4;4;5;7;6;4;6;7;6;5;2;5;3;3;5;4;5;4;6;5;1;3;5;5;5;3;6;4;5;4;3;3;6;2;4;5;5;2;4;4;4;3;4;4;7;3;4;6;2;5;5;5;4;4;3;4;4;2;3;3;6;6;5;5;4;5;3;3; GO:0031224;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0099503;GO:0043231;GO:0043234;GO:0044424;GO:0044425;GO:0043227;GO:0043226;GO:0030141;GO:0097708;GO:0044444;GO:0012505;GO:0005737;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0031201;GO:0043229;GO:0005886;GO:0032991;GO:0005575;GO:0098796; intrinsic component of membrane;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;secretory vesicle;intracellular membrane-bounded organelle;protein complex;intracellular part;membrane part;membrane-bounded organelle;organelle;secretory granule;intracellular vesicle;cytoplasmic part;endomembrane system;cytoplasm;cytoplasmic vesicle;cell part;cell;intracellular;cell periphery;SNARE complex;intracellular organelle;plasma membrane;macromolecular complex;cellular_component;membrane protein complex; 3;4;5;4;2;5;6;4;3;3;2;3;2;4;4;4;3;4;5;2;2;3;3;4;3;3;2;1;3; GO:0031267;GO:0098772;GO:0005096;GO:0030695;GO:0019905;GO:0003674;GO:0005488;GO:0000149;GO:0017016;GO:0019899;GO:0017137;GO:0060589;GO:0051020;GO:0005515;GO:0008047;GO:0030234; small GTPase binding;molecular function regulator;GTPase activator activity;GTPase regulator activity;syntaxin binding;molecular_function;binding;SNARE binding;Ras GTPase binding;enzyme binding;Rab GTPase binding;nucleoside-triphosphatase regulator activity;GTPase binding;protein binding;enzyme activator activity;enzyme regulator activity; 6;2;5;5;5;1;2;4;7;4;8;4;5;3;4;3; K08518 IPR013905;IPR017986;IPR001680;IPR001388;IPR015943;IPR019775;IPR000664;IPR013577; Lethal giant larvae (Lgl)-like, C-terminal domain;WD40-repeat-containing domain;WD40 repeat;Synaptobrevin;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;Lethal(2) giant larvae protein;Lethal giant larvae homologue 2; plasma membrane Hs20535595 2474.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q8NGJ2 Olfactory receptor 52H1 OS=Homo sapiens OX=9606 GN=OR52H1 PE=2 SV=3 - [O52H1_HUMAN] 0.879 1.608 0.95 1.005 0.908 0.608 0.546641791 nan 1.106828194 nan 0.59079602 nan 0.669603524 nan GO:0051716;GO:0007165;GO:0007154;GO:0009593;GO:0050789;GO:0065007;GO:0044699;GO:0032501;GO:0007608;GO:0050877;GO:0007606;GO:0007600;GO:0050794;GO:0050911;GO:0008150;GO:0023052;GO:0042221;GO:0003008;GO:0044700;GO:0051606;GO:0050896;GO:0044763;GO:0009987;GO:0050906;GO:0050907; cellular response to stimulus;signal transduction;cell communication;detection of chemical stimulus;regulation of biological process;biological regulation;single-organism process;multicellular organismal process;sensory perception of smell;neurological system process;sensory perception of chemical stimulus;sensory perception;regulation of cellular process;detection of chemical stimulus involved in sensory perception of smell;biological_process;signaling;response to chemical;system process;single organism signaling;detection of stimulus;response to stimulus;single-organism cellular process;cellular process;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception; 3;4;4;4;2;2;2;2;7;4;6;5;3;6;1;2;3;3;3;3;2;3;2;4;5; GO:0071944;GO:0031224;GO:0016021;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044425; cell periphery;intrinsic component of membrane;integral component of membrane;membrane;plasma membrane;cell part;cell;cellular_component;membrane part; 3;3;4;2;3;2;2;1;2; GO:0038023;GO:0060089;GO:0003674;GO:0004872;GO:0004871;GO:0004930;GO:0004888;GO:0004984;GO:0099600; signaling receptor activity;molecular transducer activity;molecular_function;receptor activity;signal transducer activity;G-protein coupled receptor activity;transmembrane signaling receptor activity;olfactory receptor activity;transmembrane receptor activity; 3;2;1;3;2;5;4;5;4; K04257 map04740; Olfactory transduction; IPR000276;IPR017452;IPR000725; G protein-coupled receptor, rhodopsin-like;GPCR, rhodopsin-like, 7TM;Olfactory receptor; plasma membrane Q9BXM0 Periaxin OS=Homo sapiens OX=9606 GN=PRX PE=1 SV=2 - [PRAX_HUMAN] 1.019 1.153 0.749 1.174 1.214 0.549 0.88378144 0.226235641 0.967051071 0.837435493 0.649609714 0.305277781 0.452224053 0.265826988 GO:0007272;GO:0044699;GO:0007275;GO:0032502;GO:0032501;GO:0009987;GO:0044767;GO:0044763;GO:0008366;GO:0048731;GO:0021675;GO:0044707;GO:0048856;GO:0007399;GO:0008150; ensheathment of neurons;single-organism process;multicellular organism development;developmental process;multicellular organismal process;cellular process;single-organism developmental process;single-organism cellular process;axon ensheathment;system development;nerve development;single-multicellular organism process;anatomical structure development;nervous system development;biological_process; 4;2;4;2;2;2;3;3;5;4;4;3;3;5;1; GO:0005886;GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0005737;GO:0043209;GO:0005634;GO:0016020;GO:0030054;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; plasma membrane;intracellular organelle;cell periphery;membrane-bounded organelle;organelle;cytoplasm;myelin sheath;nucleus;membrane;cell junction;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;3;3;2;4;3;5;2;2;4;2;2;3;1;3; IPR001478; PDZ domain; cytosol 57116904 102.0 S [S] Function unknown; COG5651 PPE-repeat protein Q9Y3E1 Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1 - [HDGR3_HUMAN] 0.634 1.215 0.581 1.045 2.045 0.322 0.5218107 nan 0.511002445 nan 0.4781893 nan 0.157457213 nan GO:0031110;GO:0031111;GO:0031114;GO:0048468;GO:0071840;GO:0048869;GO:0051494;GO:0051493;GO:0048519;GO:0031109;GO:1901880;GO:0044707;GO:0010639;GO:0070507;GO:0022607;GO:1901879;GO:0043244;GO:0050789;GO:0016043;GO:0070271;GO:0065003;GO:0065007;GO:0050794;GO:0008150;GO:0048731;GO:0022411;GO:0033043;GO:0030154;GO:0051129;GO:0051128;GO:0032886;GO:0043241;GO:0044699;GO:0043242;GO:0030030;GO:0046785;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0051258;GO:0000226;GO:0043933;GO:0031175;GO:0034622;GO:0007275;GO:0032984;GO:0071822;GO:0007026;GO:0051261;GO:0048666;GO:0030182;GO:0006461;GO:0044767;GO:0044763;GO:0022008;GO:0043624;GO:0043623;GO:0006996;GO:0048699;GO:0007017;GO:0007010;GO:0007399;GO:0048856;GO:0007019;GO:1902589;GO:0044085;GO:0048523; regulation of microtubule polymerization or depolymerization;negative regulation of microtubule polymerization or depolymerization;regulation of microtubule depolymerization;cell development;cellular component organization or biogenesis;cellular developmental process;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;negative regulation of biological process;microtubule polymerization or depolymerization;negative regulation of protein depolymerization;single-multicellular organism process;negative regulation of organelle organization;regulation of microtubule cytoskeleton organization;cellular component assembly;regulation of protein depolymerization;regulation of protein complex disassembly;regulation of biological process;cellular component organization;protein complex biogenesis;macromolecular complex assembly;biological regulation;regulation of cellular process;biological_process;system development;cellular component disassembly;regulation of organelle organization;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of microtubule-based process;protein complex disassembly;single-organism process;negative regulation of protein complex disassembly;cell projection organization;microtubule polymerization;developmental process;multicellular organismal process;cell proliferation;cellular process;protein polymerization;microtubule cytoskeleton organization;macromolecular complex subunit organization;neuron projection development;cellular macromolecular complex assembly;multicellular organism development;macromolecular complex disassembly;protein complex subunit organization;negative regulation of microtubule depolymerization;protein depolymerization;neuron development;neuron differentiation;protein complex assembly;single-organism developmental process;single-organism cellular process;neurogenesis;cellular protein complex disassembly;cellular protein complex assembly;organelle organization;generation of neurons;microtubule-based process;cytoskeleton organization;nervous system development;anatomical structure development;microtubule depolymerization;single-organism organelle organization;cellular component biogenesis;negative regulation of cellular process; 6;7;7;4;2;4;6;6;2;6;6;3;5;5;4;6;5;2;3;4;5;2;3;1;4;4;5;5;4;4;4;6;2;5;4;7;2;2;3;2;7;5;4;5;6;4;5;5;7;8;5;6;5;3;3;6;7;6;4;7;4;5;5;3;7;4;3;3; GO:0031974;GO:0005654;GO:0031981;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nucleoplasm;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 2;5;5;4;3;5;4;3;2;3;3;3;4;4;5;2;2;3;2;1;4; GO:0044877;GO:0003674;GO:0005488;GO:0008017;GO:0008092;GO:0032403;GO:0005515;GO:0015631; macromolecular complex binding;molecular_function;binding;microtubule binding;cytoskeletal protein binding;protein complex binding;protein binding;tubulin binding; 3;1;2;5;4;4;3;5; IPR000313;IPR035496; PWWP domain;HDGF-related, PWWP domain; nucleus Hs7705320 410.0 K [K] Transcription; P0DP09 Immunoglobulin kappa variable 1-13 OS=Homo sapiens OX=9606 GN=IGKV1-13 PE=3 SV=1 - [KV113_HUMAN] 0.913 1.187 0.884 1.145 1.207 0.729 0.769165965 nan 0.948632974 nan 0.744734625 nan 0.603976802 nan IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9NVR2 Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2 - [INT10_HUMAN] 1.154 0.726 1.379 0.89 0.799 1.413 1.58953168 0.004227925 1.113892365 0.170815011 1.899449036 0.005077993 1.768460576 0.003751215 GO:0090304;GO:0034641;GO:0006807;GO:0034660;GO:1901360;GO:0016180;GO:0006139;GO:0044260;GO:0071704;GO:0010467;GO:0034470;GO:0009987;GO:0006725;GO:0008150;GO:0008152;GO:0046483;GO:0016070;GO:0044238;GO:0016073;GO:0044237;GO:0043170;GO:0006396; nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;ncRNA metabolic process;organic cyclic compound metabolic process;snRNA processing;nucleobase-containing compound metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;gene expression;ncRNA processing;cellular process;cellular aromatic compound metabolic process;biological_process;metabolic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;snRNA metabolic process;cellular metabolic process;macromolecule metabolic process;RNA processing; 5;4;3;6;4;8;4;4;3;5;7;2;4;1;2;4;5;3;7;3;4;6; GO:0043231;GO:0030880;GO:0044464;GO:1990234;GO:0031974;GO:0005623;GO:0016591;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0055029;GO:0005654;GO:0044451;GO:0043234;GO:1902494;GO:0061695;GO:0044446;GO:0032039;GO:0032991;GO:0031981;GO:0043233;GO:0000428;GO:0043229;GO:0005575;GO:0070013;GO:0044428;GO:0044422;GO:0044424; intracellular membrane-bounded organelle;RNA polymerase complex;cell part;transferase complex;membrane-enclosed lumen;cell;DNA-directed RNA polymerase II, holoenzyme;intracellular;membrane-bounded organelle;organelle;nucleus;nuclear DNA-directed RNA polymerase complex;nucleoplasm;nucleoplasm part;protein complex;catalytic complex;transferase complex, transferring phosphorus-containing groups;intracellular organelle part;integrator complex;macromolecular complex;nuclear lumen;organelle lumen;DNA-directed RNA polymerase complex;intracellular organelle;cellular_component;intracellular organelle lumen;nuclear part;organelle part;intracellular part; 4;4;2;5;2;2;6;3;3;2;5;5;5;5;3;4;6;3;4;2;5;3;5;3;1;4;4;2;3; K13147 IPR026164;IPR011990; Integrator complex subunit 10;Tetratricopeptide-like helical domain; cytosol, nucleus O60343 TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2 - [TBCD4_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0051049;GO:0006906;GO:0061025;GO:0061024;GO:0071840;GO:0051716;GO:0048519;GO:0051051;GO:0043434;GO:0010033;GO:0016192;GO:0090174;GO:0010243;GO:0010639;GO:0016050;GO:0050789;GO:0016043;GO:0065007;GO:0006810;GO:0050794;GO:0044802;GO:0044801;GO:0051234;GO:0050896;GO:1901699;GO:0008150;GO:0033043;GO:0051129;GO:0051128;GO:0070887;GO:0044699;GO:0009719;GO:0071375;GO:0071495;GO:0031339;GO:0009987;GO:0060627;GO:0032870;GO:0032879;GO:0009725;GO:1901698;GO:0031338;GO:0032869;GO:0032868;GO:0071417;GO:0071310;GO:1901652;GO:0044763;GO:0042221;GO:0051179;GO:1901700;GO:1901701;GO:0006996;GO:1902589;GO:0048284;GO:1901653;GO:0048523; regulation of transport;vesicle fusion;membrane fusion;membrane organization;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of biological process;negative regulation of transport;response to peptide hormone;response to organic substance;vesicle-mediated transport;organelle membrane fusion;response to organonitrogen compound;negative regulation of organelle organization;vesicle organization;regulation of biological process;cellular component organization;biological regulation;transport;regulation of cellular process;single-organism membrane organization;single-organism membrane fusion;establishment of localization;response to stimulus;cellular response to nitrogen compound;biological_process;regulation of organelle organization;negative regulation of cellular component organization;regulation of cellular component organization;cellular response to chemical stimulus;single-organism process;response to endogenous stimulus;cellular response to peptide hormone stimulus;cellular response to endogenous stimulus;negative regulation of vesicle fusion;cellular process;regulation of vesicle-mediated transport;cellular response to hormone stimulus;regulation of localization;response to hormone;response to nitrogen compound;regulation of vesicle fusion;cellular response to insulin stimulus;response to insulin;cellular response to organonitrogen compound;cellular response to organic substance;response to peptide;single-organism cellular process;response to chemical;localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;organelle organization;single-organism organelle organization;organelle fusion;cellular response to peptide;negative regulation of cellular process; 4;6;5;4;2;3;2;3;5;4;5;5;4;5;5;2;3;2;4;3;4;5;3;2;5;1;5;4;4;4;2;3;6;4;4;2;4;5;3;4;4;5;7;6;5;5;5;3;3;2;4;5;4;4;5;6;3; GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044433;GO:0005737;GO:0097708;GO:0012506;GO:0031090;GO:0044446;GO:0044444;GO:0031410;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576; vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;cytoplasm;intracellular vesicle;vesicle membrane;organelle membrane;intracellular organelle part;cytoplasmic part;cytoplasmic vesicle;cytoplasmic vesicle membrane;cell part;cell;intracellular;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region; 4;5;2;5;3;4;3;2;2;3;3;4;4;4;4;3;3;4;5;5;2;2;3;4;2;3;1;2; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;5;5;1;4;4;3; K17902 map04919;map04931; Thyroid hormone signaling pathway;Insulin resistance; IPR000195;IPR033564;IPR011993;IPR006020;IPR021785; Rab-GTPase-TBC domain;TBC1 domain family member 4;PH domain-like;PTB/PI domain;Domain of unknown function DUF3350; nucleus Hs7662198 2675.0 R [R] General function prediction only; P0DP02 Immunoglobulin heavy variable 3-30-3 OS=Homo sapiens OX=9606 GN=IGHV3-30-3 PE=3 SV=1 - [HVC33_HUMAN] 1.132 1.075 0.697 1.04 1.345 0.879 1.053023256 nan 0.773234201 nan 0.648372093 nan 0.653531599 nan IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P19021 Peptidyl-glycine alpha-amidating monooxygenase OS=Homo sapiens OX=9606 GN=PAM PE=1 SV=2 - [AMD_HUMAN] 0.696 1.073 1.126 0.847 1.489 0.534 0.648648649 4.40E-10 0.568838146 1.17E-05 1.049394222 0.191517909 0.358629953 5.23E-09 GO:0008104;GO:0080090;GO:0051046;GO:0007595;GO:0051049;GO:0043603;GO:0006139;GO:0072358;GO:1901576;GO:1901362;GO:0071840;GO:0032774;GO:0065003;GO:0044710;GO:0010035;GO:0000003;GO:0071704;GO:0051493;GO:0033043;GO:0048511;GO:0048513;GO:0018032;GO:0060255;GO:0031960;GO:0032787;GO:0045184;GO:0007507;GO:0010038;GO:2001141;GO:0043436;GO:1901564;GO:0010033;GO:0001519;GO:0051704;GO:0044703;GO:0044702;GO:0044707;GO:0044706;GO:0019538;GO:0072359;GO:0046483;GO:0042698;GO:0007565;GO:0032970;GO:1903530;GO:0022607;GO:0022602;GO:0042493;GO:0060173;GO:0009887;GO:0032941;GO:0030036;GO:0051223;GO:0097659;GO:0044267;GO:0009653;GO:0050708;GO:0006357;GO:0016043;GO:0065007;GO:0014070;GO:0006366;GO:0065008;GO:0044281;GO:0030879;GO:0018130;GO:0070201;GO:0019748;GO:0006629;GO:0009306;GO:0006810;GO:0009889;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0019438;GO:0001676;GO:0009268;GO:0051234;GO:0016070;GO:0044767;GO:0046903;GO:0044271;GO:0036293;GO:0050896;GO:0043412;GO:0006355;GO:0010556;GO:0048545;GO:0006518;GO:0097305;GO:0006631;GO:0008152;GO:0070271;GO:0032956;GO:0051128;GO:0044249;GO:0034641;GO:1901360;GO:0034645;GO:0001666;GO:0044699;GO:0007417;GO:0009719;GO:0032880;GO:0051641;GO:0032502;GO:0006996;GO:0032501;GO:0048609;GO:0050878;GO:0044238;GO:0009987;GO:0006725;GO:1903506;GO:0009058;GO:0009404;GO:0044255;GO:0032879;GO:0051259;GO:0033036;GO:2000112;GO:0006082;GO:0009725;GO:0051252;GO:0032940;GO:0006807;GO:0048731;GO:0048732;GO:0048736;GO:0051384;GO:0060341;GO:0043933;GO:0031326;GO:1990267;GO:0031323;GO:0019752;GO:0090304;GO:0043170;GO:0044237;GO:0060135;GO:0007275;GO:0032355;GO:0032504;GO:0071822;GO:0033993;GO:0051260;GO:0050789;GO:0010467;GO:0044085;GO:0031179;GO:0046688;GO:0071702;GO:0010468;GO:0006351;GO:0030029;GO:0007589;GO:0019219;GO:0006461;GO:0006464;GO:0022414;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0043627;GO:0042221;GO:0019222;GO:0051179;GO:1902578;GO:0070482;GO:1901700;GO:0009628;GO:0007010;GO:0044260;GO:0007399;GO:0042476;GO:0048856;GO:1902589;GO:0015031;GO:0034654; protein localization;regulation of primary metabolic process;regulation of secretion;lactation;regulation of transport;cellular amide metabolic process;nucleobase-containing compound metabolic process;cardiovascular system development;organic substance biosynthetic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;RNA biosynthetic process;macromolecular complex assembly;single-organism metabolic process;response to inorganic substance;reproduction;organic substance metabolic process;regulation of cytoskeleton organization;regulation of organelle organization;rhythmic process;animal organ development;protein amidation;regulation of macromolecule metabolic process;response to corticosteroid;monocarboxylic acid metabolic process;establishment of protein localization;heart development;response to metal ion;regulation of RNA biosynthetic process;oxoacid metabolic process;organonitrogen compound metabolic process;response to organic substance;peptide amidation;multi-organism process;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;multi-multicellular organism process;protein metabolic process;circulatory system development;heterocycle metabolic process;ovulation cycle;female pregnancy;regulation of actin filament-based process;regulation of secretion by cell;cellular component assembly;ovulation cycle process;response to drug;limb development;organ morphogenesis;secretion by tissue;actin cytoskeleton organization;regulation of protein transport;nucleic acid-templated transcription;cellular protein metabolic process;anatomical structure morphogenesis;regulation of protein secretion;regulation of transcription from RNA polymerase II promoter;cellular component organization;biological regulation;response to organic cyclic compound;transcription from RNA polymerase II promoter;regulation of biological quality;small molecule metabolic process;mammary gland development;heterocycle biosynthetic process;regulation of establishment of protein localization;secondary metabolic process;lipid metabolic process;protein secretion;transport;regulation of biosynthetic process;regulation of cellular process;response to stress;protein modification process;biological_process;aromatic compound biosynthetic process;long-chain fatty acid metabolic process;response to pH;establishment of localization;RNA metabolic process;single-organism developmental process;secretion;cellular nitrogen compound biosynthetic process;response to decreased oxygen levels;response to stimulus;macromolecule modification;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;response to steroid hormone;peptide metabolic process;response to alcohol;fatty acid metabolic process;metabolic process;protein complex biogenesis;regulation of actin cytoskeleton organization;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;organic cyclic compound metabolic process;cellular macromolecule biosynthetic process;response to hypoxia;single-organism process;central nervous system development;response to endogenous stimulus;regulation of protein localization;cellular localization;developmental process;organelle organization;multicellular organismal process;multicellular organismal reproductive process;regulation of body fluid levels;primary metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;biosynthetic process;toxin metabolic process;cellular lipid metabolic process;regulation of localization;protein oligomerization;macromolecule localization;regulation of cellular macromolecule biosynthetic process;organic acid metabolic process;response to hormone;regulation of RNA metabolic process;secretion by cell;nitrogen compound metabolic process;system development;gland development;appendage development;response to glucocorticoid;regulation of cellular localization;macromolecular complex subunit organization;regulation of cellular biosynthetic process;response to transition metal nanoparticle;regulation of cellular metabolic process;carboxylic acid metabolic process;nucleic acid metabolic process;macromolecule metabolic process;cellular metabolic process;maternal process involved in female pregnancy;multicellular organism development;response to estradiol;multicellular organism reproduction;protein complex subunit organization;response to lipid;protein homooligomerization;regulation of biological process;gene expression;cellular component biogenesis;peptide modification;response to copper ion;organic substance transport;regulation of gene expression;transcription, DNA-templated;actin filament-based process;body fluid secretion;regulation of nucleobase-containing compound metabolic process;protein complex assembly;cellular protein modification process;reproductive process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;response to estrogen;response to chemical;regulation of metabolic process;localization;single-organism localization;response to oxygen levels;response to oxygen-containing compound;response to abiotic stimulus;cytoskeleton organization;cellular macromolecule metabolic process;nervous system development;odontogenesis;anatomical structure development;single-organism organelle organization;protein transport;nucleobase-containing compound biosynthetic process; 4;4;5;5;4;5;4;5;4;5;2;6;5;3;4;2;3;6;5;2;4;7;4;6;7;4;4;5;6;5;4;4;7;2;3;3;3;3;4;5;4;3;4;4;5;4;3;4;5;4;4;5;5;7;5;3;6;7;3;2;5;7;3;4;5;5;5;4;4;5;4;4;3;3;5;1;5;6;4;3;5;3;5;5;5;2;5;6;5;5;5;5;5;2;4;5;4;4;4;4;5;4;2;5;3;4;3;2;4;2;3;4;3;2;4;7;3;4;4;3;6;3;6;4;4;5;4;3;4;4;4;7;4;4;5;4;4;6;5;4;3;4;4;6;3;5;5;7;2;5;3;6;5;5;5;6;4;5;5;5;6;2;4;5;3;4;6;3;3;2;3;4;4;3;5;4;5;5;3;4;5;5; GO:0031224;GO:0016023;GO:0005615;GO:0016021;GO:0016020;GO:0031988;GO:0005794;GO:0099503;GO:0098588;GO:0044297;GO:0036477;GO:0042995;GO:0043230;GO:0043231;GO:0043025;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0044431;GO:0048471;GO:0030141;GO:0097708;GO:0012506;GO:0043204;GO:0031982;GO:0044446;GO:0044444;GO:0012505;GO:0030667;GO:0031090;GO:0031410;GO:0043005;GO:0009986;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098805;GO:0070062;GO:0097458;GO:0005802;GO:0031984;GO:0005886;GO:1903561;GO:0005737;GO:0005575;GO:0005576;GO:0098791; intrinsic component of membrane;cytoplasmic, membrane-bounded vesicle;extracellular space;integral component of membrane;membrane;membrane-bounded vesicle;Golgi apparatus;secretory vesicle;bounding membrane of organelle;cell body;somatodendritic compartment;cell projection;extracellular organelle;intracellular membrane-bounded organelle;neuronal cell body;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;Golgi apparatus part;perinuclear region of cytoplasm;secretory granule;intracellular vesicle;vesicle membrane;perikaryon;vesicle;intracellular organelle part;cytoplasmic part;endomembrane system;secretory granule membrane;organelle membrane;cytoplasmic vesicle;neuron projection;cell surface;cytoplasmic vesicle membrane;cell part;cell;intracellular;cell periphery;whole membrane;extracellular exosome;neuron part;trans-Golgi network;organelle subcompartment;plasma membrane;extracellular vesicle;cytoplasm;cellular_component;extracellular region;Golgi subcompartment; 3;5;3;4;2;5;4;6;4;3;4;3;3;4;4;3;2;2;2;3;3;2;4;4;5;4;4;4;4;4;3;4;3;4;3;5;4;3;5;2;2;3;3;3;4;3;5;4;3;3;4;1;2;5; GO:0016491;GO:0004497;GO:0008270;GO:0046872;GO:0003674;GO:0005488;GO:0046914;GO:0005507;GO:0043168;GO:0031418;GO:0003824;GO:0031406;GO:0048029;GO:0043169;GO:0016829;GO:0016705;GO:0043167;GO:0005509;GO:0043177;GO:0004598;GO:0030246;GO:0016715;GO:0004504;GO:0016842;GO:0036094;GO:0019842;GO:0016840; oxidoreductase activity;monooxygenase activity;zinc ion binding;metal ion binding;molecular_function;binding;transition metal ion binding;copper ion binding;anion binding;L-ascorbic acid binding;catalytic activity;carboxylic acid binding;monosaccharide binding;cation binding;lyase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;ion binding;calcium ion binding;organic acid binding;peptidylamidoglycolate lyase activity;carbohydrate binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen;peptidylglycine monooxygenase activity;amidine-lyase activity;small molecule binding;vitamin binding;carbon-nitrogen lyase activity; 3;4;7;5;1;2;6;7;4;5;2;5;4;4;3;4;3;6;4;6;3;5;6;5;3;4;4; K18200 IPR013017;IPR000720;IPR020611;IPR024548;IPR001258;IPR000323;IPR011042;IPR014783;IPR014784;IPR008977; NHL repeat, subgroup;Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase;Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site;Copper type II ascorbate-dependent monooxygenase, C-terminal;NHL repeat;Copper type II, ascorbate-dependent monooxygenase, N-terminal;Six-bladed beta-propeller, TolB-like;Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site;Copper type II, ascorbate-dependent monooxygenase-like, C-terminal;PHM/PNGase F domain; plasma membrane Hs21070984 2019.0 O [O] Posttranslational modification, protein turnover, chaperones; P46821 Microtubule-associated protein 1B OS=Homo sapiens OX=9606 GN=MAP1B PE=1 SV=2 - [MAP1B_HUMAN] 1.145 1.36 0.61 0.997 1.056 1.374 0.841911765 nan 0.944128788 nan 0.448529412 nan 1.301136364 nan GO:0048675;GO:0048589;GO:0048588;GO:0051049;GO:0032386;GO:0032387;GO:0048468;GO:0016358;GO:0007163;GO:0051654;GO:0051656;GO:0031344;GO:0071840;GO:0031346;GO:0048869;GO:0045664;GO:0045666;GO:0010720;GO:0048522;GO:0048518;GO:0048519;GO:1990138;GO:0051051;GO:0008361;GO:0010970;GO:0010975;GO:0030516;GO:0050770;GO:0044707;GO:0051094;GO:0061387;GO:0032535;GO:0022604;GO:0022603;GO:0006928;GO:0000226;GO:0031175;GO:0050789;GO:0061162;GO:0000904;GO:0016049;GO:0000902;GO:0016043;GO:0090066;GO:0065007;GO:0065008;GO:0051130;GO:0061564;GO:0050793;GO:0006810;GO:0050794;GO:0008150;GO:0051239;GO:0010770;GO:0051234;GO:0046907;GO:0001578;GO:0072384;GO:0051962;GO:0048812;GO:0048639;GO:0048638;GO:0030307;GO:0030154;GO:0051128;GO:0034643;GO:0030010;GO:0009653;GO:0044699;GO:0050767;GO:0050769;GO:0051240;GO:0047497;GO:0060284;GO:0030705;GO:0051640;GO:0060560;GO:0032502;GO:0032501;GO:0009987;GO:0045597;GO:0045595;GO:0001558;GO:0007409;GO:0032879;GO:0032990;GO:0007399;GO:0050772;GO:0048731;GO:0045927;GO:0060341;GO:0030030;GO:0045773;GO:0007275;GO:0040007;GO:0040008;GO:0032989;GO:0051960;GO:0048666;GO:0048667;GO:0030182;GO:0061339;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0051646;GO:0010769;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0048699;GO:0007017;GO:0007010;GO:0048858;GO:0048856;GO:0007018;GO:1902589;GO:2000026;GO:1902582;GO:1902580;GO:0010976; axon extension;developmental growth;developmental cell growth;regulation of transport;regulation of intracellular transport;negative regulation of intracellular transport;cell development;dendrite development;establishment or maintenance of cell polarity;establishment of mitochondrion localization;establishment of organelle localization;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;cellular developmental process;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of cell development;positive regulation of cellular process;positive regulation of biological process;negative regulation of biological process;neuron projection extension;negative regulation of transport;regulation of cell size;establishment of localization by movement along microtubule;regulation of neuron projection development;regulation of axon extension;regulation of axonogenesis;single-multicellular organism process;positive regulation of developmental process;regulation of extent of cell growth;regulation of cellular component size;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;microtubule cytoskeleton organization;neuron projection development;regulation of biological process;establishment of monopolar cell polarity;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;cellular component organization;regulation of anatomical structure size;biological regulation;regulation of biological quality;positive regulation of cellular component organization;axon development;regulation of developmental process;transport;regulation of cellular process;biological_process;regulation of multicellular organismal process;positive regulation of cell morphogenesis involved in differentiation;establishment of localization;intracellular transport;microtubule bundle formation;organelle transport along microtubule;positive regulation of nervous system development;neuron projection morphogenesis;positive regulation of developmental growth;regulation of developmental growth;positive regulation of cell growth;cell differentiation;regulation of cellular component organization;establishment of mitochondrion localization, microtubule-mediated;establishment of cell polarity;anatomical structure morphogenesis;single-organism process;regulation of neurogenesis;positive regulation of neurogenesis;positive regulation of multicellular organismal process;mitochondrion transport along microtubule;regulation of cell development;cytoskeleton-dependent intracellular transport;organelle localization;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;regulation of cell growth;axonogenesis;regulation of localization;cell part morphogenesis;nervous system development;positive regulation of axonogenesis;system development;positive regulation of growth;regulation of cellular localization;cell projection organization;positive regulation of axon extension;multicellular organism development;growth;regulation of growth;cellular component morphogenesis;regulation of nervous system development;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;establishment or maintenance of monopolar cell polarity;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;mitochondrion localization;regulation of cell morphogenesis involved in differentiation;neurogenesis;localization;single-organism localization;cellular localization;organelle organization;generation of neurons;microtubule-based process;cytoskeleton organization;cell projection morphogenesis;anatomical structure development;microtubule-based movement;single-organism organelle organization;regulation of multicellular organismal development;single-organism intracellular transport;single-organism cellular localization;positive regulation of neuron projection development; 6;3;4;4;5;4;4;4;4;5;4;5;2;5;4;7;6;5;3;2;2;5;3;5;4;6;5;7;3;3;5;4;5;4;4;5;5;2;6;5;3;5;3;4;2;3;4;6;3;4;3;1;3;5;3;5;6;5;4;6;4;4;4;5;4;5;5;3;2;6;5;3;6;5;6;4;4;2;2;2;4;4;4;7;3;5;5;6;4;3;4;4;5;4;2;3;4;5;5;6;6;5;3;4;3;4;5;6;6;2;3;3;4;7;4;5;5;3;5;4;4;5;4;6; GO:0099512;GO:0099513;GO:0030425;GO:0016020;GO:0031513;GO:0097481;GO:0060076;GO:0036477;GO:0042995;GO:0001750;GO:0043234;GO:0043232;GO:0005829;GO:0044424;GO:0043229;GO:0043228;GO:0005856;GO:0044430;GO:0030054;GO:0005886;GO:0044446;GO:0044444;GO:0044422;GO:0005874;GO:0005875;GO:0005737;GO:0044456;GO:0043005;GO:0014069;GO:0032991;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0005929;GO:0099572;GO:0071944;GO:0045202;GO:0072372;GO:0044309;GO:0097458;GO:0015630;GO:0043197;GO:0005575;GO:0098794;GO:0043226; supramolecular fiber;polymeric cytoskeletal fiber;dendrite;membrane;nonmotile primary cilium;neuronal postsynaptic density;excitatory synapse;somatodendritic compartment;cell projection;photoreceptor outer segment;protein complex;intracellular non-membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;cytoskeletal part;cell junction;plasma membrane;intracellular organelle part;cytoplasmic part;organelle part;microtubule;microtubule associated complex;cytoplasm;synapse part;neuron projection;postsynaptic density;macromolecular complex;cell projection part;cell part;cell;intracellular;cilium;postsynaptic specialization;cell periphery;synapse;primary cilium;neuron spine;neuron part;microtubule cytoskeleton;dendritic spine;cellular_component;postsynapse;organelle; 2;3;5;2;5;4;3;4;3;4;3;4;5;3;3;3;5;4;2;3;3;4;2;4;4;4;2;4;4;2;3;2;2;3;3;3;3;2;4;5;3;6;4;1;3;2; GO:0005198;GO:0003674; structural molecule activity;molecular_function; 2;1; K10429 IPR000102;IPR026074;IPR027321; Neuraxin/MAP1B repeat;Microtubule associated protein 1;Microtubule-associated protein 1B; nucleus Hs5174525 4970.0 Z [Z] Cytoskeleton; Q9NPY3 Complement component C1q receptor OS=Homo sapiens OX=9606 GN=CD93 PE=1 SV=3 - [C1QR1_HUMAN] 0.921 1.03 1.041 1.503 0.829 0.875 0.894174757 nan 1.813027744 nan 1.010679612 nan 1.05548854 nan GO:0006909;GO:0050688;GO:0048583;GO:0098779;GO:0071840;GO:0044712;GO:0044710;GO:0043207;GO:0009615;GO:0044419;GO:0065007;GO:0051707;GO:0051704;GO:0009607;GO:0009605;GO:0002274;GO:0002376;GO:0033554;GO:0043900;GO:0002831;GO:1903008;GO:0045321;GO:0050789;GO:0016043;GO:0002682;GO:0007005;GO:0098602;GO:0098609;GO:0006810;GO:0051716;GO:0006952;GO:0001775;GO:0008150;GO:0008152;GO:0031347;GO:0051234;GO:0006897;GO:0051607;GO:0050896;GO:0006950;GO:0002697;GO:0022411;GO:0032101;GO:0044699;GO:0022610;GO:0009987;GO:0098542;GO:0000422;GO:0000423;GO:0002230;GO:0080134;GO:0016337;GO:0042116;GO:0016236;GO:0098780;GO:0061726;GO:0006914;GO:0050691;GO:0044765;GO:0044764;GO:0044763;GO:0007155;GO:0009056;GO:0051179;GO:1902578;GO:0006996;GO:1902589;GO:0098792;GO:0016032;GO:0002252;GO:0044403;GO:0016192; phagocytosis;regulation of defense response to virus;regulation of response to stimulus;mitophagy in response to mitochondrial depolarization;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;response to external biotic stimulus;response to virus;interspecies interaction between organisms;biological regulation;response to other organism;multi-organism process;response to biotic stimulus;response to external stimulus;myeloid leukocyte activation;immune system process;cellular response to stress;regulation of multi-organism process;regulation of response to biotic stimulus;organelle disassembly;leukocyte activation;regulation of biological process;cellular component organization;regulation of immune system process;mitochondrion organization;single organism cell adhesion;cell-cell adhesion;transport;cellular response to stimulus;defense response;cell activation;biological_process;metabolic process;regulation of defense response;establishment of localization;endocytosis;defense response to virus;response to stimulus;response to stress;regulation of immune effector process;cellular component disassembly;regulation of response to external stimulus;single-organism process;biological adhesion;cellular process;defense response to other organism;mitophagy;macromitophagy;positive regulation of defense response to virus by host;regulation of response to stress;single organismal cell-cell adhesion;macrophage activation;macroautophagy;response to mitochondrial depolarisation;mitochondrion disassembly;autophagy;regulation of defense response to virus by host;single-organism transport;multi-organism cellular process;single-organism cellular process;cell adhesion;catabolic process;localization;single-organism localization;organelle organization;single-organism organelle organization;xenophagy;viral process;immune effector process;symbiosis, encompassing mutualism through parasitism;vesicle-mediated transport; 5;4;3;6;2;4;3;4;4;3;2;3;2;3;3;4;2;4;3;4;5;3;2;3;3;5;3;4;4;3;4;4;1;2;5;3;6;4;2;3;4;4;4;2;2;2;4;4;5;6;4;4;5;4;5;6;3;5;4;3;3;3;3;2;3;4;4;5;4;3;4;5; GO:0031224;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0043231;GO:0044424;GO:0044425;GO:0043229;GO:0043227;GO:0097708;GO:0005737;GO:0031410;GO:0009986;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0044444;GO:0043226;GO:0005886;GO:0005575; intrinsic component of membrane;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;intracellular membrane-bounded organelle;intracellular part;membrane part;intracellular organelle;membrane-bounded organelle;intracellular vesicle;cytoplasm;cytoplasmic vesicle;cell surface;cell part;cell;intracellular;cell periphery;cytoplasmic part;organelle;plasma membrane;cellular_component; 3;4;5;4;2;5;4;3;2;3;3;4;4;5;3;2;2;3;3;4;2;3;1; GO:0060089;GO:0046872;GO:0003674;GO:0005488;GO:0001849;GO:0001848;GO:0001846;GO:0043169;GO:0043167;GO:0005509;GO:0005515;GO:0030246;GO:0004872; molecular transducer activity;metal ion binding;molecular_function;binding;complement component C1q binding;complement binding;opsonin binding;cation binding;ion binding;calcium ion binding;protein binding;carbohydrate binding;receptor activity; 2;5;1;2;5;4;4;4;3;6;3;3;3; K06702 IPR000152;IPR018097;IPR016186;IPR009030;IPR016187;IPR000742;IPR001304;IPR026823;IPR001881;IPR013032; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;C-type lectin-like/link domain;Growth factor receptor cysteine-rich domain;C-type lectin fold;EGF-like domain;C-type lectin-like;Complement Clr-like EGF domain;EGF-like calcium-binding domain;EGF-like, conserved site; plasma membrane O75015 Low affinity immunoglobulin gamma Fc region receptor III-B OS=Homo sapiens OX=9606 GN=FCGR3B PE=1 SV=2 - [FCG3B_HUMAN] 1.025 1.04 1.223 1.044 0.742 1.277 0.985576923 nan 1.407008086 nan 1.175961538 nan 1.721024259 nan GO:0050688;GO:0032101;GO:0016236;GO:1903008;GO:0098779;GO:0080134;GO:0007005;GO:0071840;GO:0044712;GO:0044710;GO:0043207;GO:0009615;GO:0002697;GO:0016043;GO:0050789;GO:0098780;GO:0002230;GO:0002682;GO:0044699;GO:0065007;GO:0051707;GO:0051704;GO:0009605;GO:0061726;GO:0002831;GO:0006914;GO:0009987;GO:0051716;GO:0048583;GO:0050691;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0009607;GO:0031347;GO:0009056;GO:0006996;GO:0051607;GO:0000422;GO:0000423;GO:0098542;GO:0050896;GO:0043900;GO:0002376;GO:1902589;GO:0098792;GO:0033554;GO:0002252;GO:0044763;GO:0022411; regulation of defense response to virus;regulation of response to external stimulus;macroautophagy;organelle disassembly;mitophagy in response to mitochondrial depolarization;regulation of response to stress;mitochondrion organization;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;response to external biotic stimulus;response to virus;regulation of immune effector process;cellular component organization;regulation of biological process;response to mitochondrial depolarisation;positive regulation of defense response to virus by host;regulation of immune system process;single-organism process;biological regulation;response to other organism;multi-organism process;response to external stimulus;mitochondrion disassembly;regulation of response to biotic stimulus;autophagy;cellular process;cellular response to stimulus;regulation of response to stimulus;regulation of defense response to virus by host;defense response;response to stress;biological_process;metabolic process;immune response;response to biotic stimulus;regulation of defense response;catabolic process;organelle organization;defense response to virus;mitophagy;macromitophagy;defense response to other organism;response to stimulus;regulation of multi-organism process;immune system process;single-organism organelle organization;xenophagy;cellular response to stress;immune effector process;single-organism cellular process;cellular component disassembly; 4;4;4;5;6;4;5;2;4;3;4;4;4;3;2;5;6;3;2;2;3;2;3;6;4;3;2;3;3;5;4;3;1;2;3;3;5;3;4;4;4;5;4;2;3;2;4;5;4;3;3;4; GO:0005886;GO:0031224;GO:0071944;GO:0043227;GO:0043226;GO:0031225;GO:0005575;GO:0070062;GO:0016020;GO:0044425;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005576;GO:0044421; plasma membrane;intrinsic component of membrane;cell periphery;membrane-bounded organelle;organelle;anchored component of membrane;cellular_component;extracellular exosome;membrane;membrane part;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;extracellular region;extracellular region part; 3;3;3;3;2;4;1;4;2;2;3;4;3;2;2;2;2; K06463 map04145;map04380;map04650;map05140;map05150;map05152;map05322; Phagosome;Osteoclast differentiation;Natural killer cell mediated cytotoxicity;Leishmaniasis;Staphylococcus aureus infection;Tuberculosis;Systemic lupus erythematosus; IPR003599;IPR007110;IPR013783; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold; extracellular Q5T890 DNA excision repair protein ERCC-6-like 2 OS=Homo sapiens OX=9606 GN=ERCC6L2 PE=1 SV=2 - [ER6L2_HUMAN] 1.27 1.428 0.781 0.556 1.399 nan 0.889355742 nan 0.397426733 nan 0.546918768 nan nan nan GO:0044710;GO:0090304;GO:0034641;GO:0006807;GO:0044699;GO:0006139;GO:0051716;GO:0044260;GO:0071704;GO:1901360;GO:0006281;GO:0009987;GO:0006725;GO:0006974;GO:0006950;GO:0008150;GO:0008152;GO:0046483;GO:0044238;GO:0050896;GO:0044237;GO:0043170;GO:0033554;GO:0006259;GO:0044763; single-organism metabolic process;nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;cellular response to stimulus;cellular macromolecule metabolic process;organic substance metabolic process;organic cyclic compound metabolic process;DNA repair;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;response to stress;biological_process;metabolic process;heterocycle metabolic process;primary metabolic process;response to stimulus;cellular metabolic process;macromolecule metabolic process;cellular response to stress;DNA metabolic process;single-organism cellular process; 3;5;4;3;2;4;3;4;3;4;4;2;4;5;3;1;2;4;3;2;3;4;4;5;3; GO:0005623;GO:0044424;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0005739;GO:0005815;GO:0044430;GO:0044446;GO:0015630;GO:0043229;GO:0043231;GO:0043232;GO:0005856;GO:0044464;GO:0005575;GO:0044444;GO:0043228;GO:0044422; cell;intracellular part;intracellular;membrane-bounded organelle;organelle;cytoplasm;nucleus;mitochondrion;microtubule organizing center;cytoskeletal part;intracellular organelle part;microtubule cytoskeleton;intracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytoskeleton;cell part;cellular_component;cytoplasmic part;non-membrane-bounded organelle;organelle part; 2;3;3;3;2;4;5;5;5;4;3;6;3;4;4;5;2;1;4;3;2; GO:0032550;GO:0003676;GO:0008026;GO:0035639;GO:1901363;GO:0036094;GO:0003674;GO:0016887;GO:0003677;GO:0001883;GO:0001882;GO:0042623;GO:0043167;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0000166;GO:0017111;GO:1901265;GO:0004386;GO:0003824;GO:0032555;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032559;GO:0032553;GO:0070035;GO:0043168;GO:0005488; purine ribonucleoside binding;nucleic acid binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;heterocyclic compound binding;small molecule binding;molecular_function;ATPase activity;DNA binding;purine nucleoside binding;nucleoside binding;ATPase activity, coupled;ion binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;nucleotide binding;nucleoside-triphosphatase activity;nucleoside phosphate binding;helicase activity;catalytic activity;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;adenyl ribonucleotide binding;ribonucleotide binding;purine NTP-dependent helicase activity;anion binding;binding; 6;4;10;5;3;3;1;8;5;5;4;9;3;5;5;6;3;4;7;4;8;2;5;5;6;3;3;4;6;6;4;9;4;2; K20098 IPR000330;IPR029256;IPR001650;IPR002464;IPR014001;IPR027417; SNF2-related, N-terminal domain;Helicase-associated putative binding domain;Helicase, C-terminal;DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;Helicase superfamily 1/2, ATP-binding domain;P-loop containing nucleoside triphosphate hydrolase; nucleus 332980995 231.0 S [S] Function unknown; COG4715 Uncharacterized conserved protein, contains Zn finger domain Q5VWT5 FYN-binding protein 2 OS=Homo sapiens OX=9606 GN=FYB2 PE=1 SV=1 - [FYB2_HUMAN] 0.752 0.835 0.609 1.522 1.805 0.529 0.900598802 nan 0.843213296 nan 0.729341317 nan 0.293074792 nan IPR001452;IPR029294; SH3 domain;Helically-extended SH3 domain; nucleus P00367 Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2 - [DHE3_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0090087;GO:0032024;GO:0008104;GO:0051046;GO:0051047;GO:0060322;GO:0044281;GO:0044282;GO:0044283;GO:0072350;GO:0044712;GO:0044710;GO:0044711;GO:0043650;GO:0006541;GO:0046879;GO:0048513;GO:0051049;GO:0048518;GO:0033036;GO:0051050;GO:0045184;GO:0090276;GO:0090277;GO:0043436;GO:1901565;GO:0043649;GO:0044700;GO:1901564;GO:1901566;GO:0016054;GO:0016053;GO:0021762;GO:0044707;GO:1903532;GO:0009063;GO:0032940;GO:0006807;GO:0009065;GO:0009064;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0030073;GO:1901576;GO:1901575;GO:1904951;GO:0050708;GO:0065007;GO:0065008;GO:0070201;GO:0009306;GO:0006810;GO:0050796;GO:0050794;GO:0008150;GO:0008152;GO:0048731;GO:0034641;GO:0051234;GO:0008652;GO:0046903;GO:0007420;GO:0050714;GO:0046394;GO:0009058;GO:0044767;GO:0043648;GO:0023056;GO:0044249;GO:0015833;GO:0023052;GO:1903530;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0032880;GO:0042886;GO:0044248;GO:1901605;GO:1901607;GO:1901606;GO:0032502;GO:0032501;GO:0009987;GO:0046883;GO:0046887;GO:0032879;GO:0007399;GO:0006082;GO:0006536;GO:0006537;GO:0046395;GO:0009084;GO:0006538;GO:0048856;GO:0060341;GO:0019752;GO:0007275;GO:0007417;GO:0006520;GO:0071705;GO:0071704;GO:0071702;GO:0023061;GO:0010817;GO:0044765;GO:0044763;GO:0007267;GO:0007154;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0002790;GO:0002791;GO:0048857;GO:0002793;GO:0044237;GO:0009914;GO:0030901;GO:0015031;GO:0048522; regulation of peptide transport;positive regulation of insulin secretion;protein localization;regulation of secretion;positive regulation of secretion;head development;small molecule metabolic process;small molecule catabolic process;small molecule biosynthetic process;tricarboxylic acid metabolic process;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;dicarboxylic acid biosynthetic process;glutamine metabolic process;hormone secretion;animal organ development;regulation of transport;positive regulation of biological process;macromolecule localization;positive regulation of transport;establishment of protein localization;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;oxoacid metabolic process;organonitrogen compound catabolic process;dicarboxylic acid catabolic process;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;organic acid catabolic process;organic acid biosynthetic process;substantia nigra development;single-multicellular organism process;positive regulation of secretion by cell;cellular amino acid catabolic process;secretion by cell;nitrogen compound metabolic process;glutamine family amino acid catabolic process;glutamine family amino acid metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;organic substance biosynthetic process;organic substance catabolic process;positive regulation of establishment of protein localization;regulation of protein secretion;biological regulation;regulation of biological quality;regulation of establishment of protein localization;protein secretion;transport;regulation of insulin secretion;regulation of cellular process;biological_process;metabolic process;system development;cellular nitrogen compound metabolic process;establishment of localization;cellular amino acid biosynthetic process;secretion;brain development;positive regulation of protein secretion;carboxylic acid biosynthetic process;biosynthetic process;single-organism developmental process;dicarboxylic acid metabolic process;positive regulation of signaling;cellular biosynthetic process;peptide transport;signaling;regulation of secretion by cell;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of protein localization;amide transport;cellular catabolic process;alpha-amino acid metabolic process;alpha-amino acid biosynthetic process;alpha-amino acid catabolic process;developmental process;multicellular organismal process;cellular process;regulation of hormone secretion;positive regulation of hormone secretion;regulation of localization;nervous system development;organic acid metabolic process;glutamate metabolic process;glutamate biosynthetic process;carboxylic acid catabolic process;glutamine family amino acid biosynthetic process;glutamate catabolic process;anatomical structure development;regulation of cellular localization;carboxylic acid metabolic process;multicellular organism development;central nervous system development;cellular amino acid metabolic process;nitrogen compound transport;organic substance metabolic process;organic substance transport;signal release;regulation of hormone levels;single-organism transport;single-organism cellular process;cell-cell signaling;cell communication;catabolic process;localization;single-organism localization;cellular localization;primary metabolic process;peptide secretion;regulation of peptide secretion;neural nucleus development;positive regulation of peptide secretion;cellular metabolic process;hormone transport;midbrain development;protein transport;positive regulation of cellular process; 5;6;4;5;4;4;4;5;5;7;4;3;4;7;7;6;4;4;2;3;3;4;5;5;5;5;7;3;4;5;5;5;5;3;4;5;4;3;7;6;4;5;2;7;6;4;4;3;6;2;3;5;5;4;6;3;1;2;4;4;3;5;5;4;5;6;3;3;7;3;4;6;2;5;3;4;4;2;4;5;4;5;6;6;2;2;2;4;4;3;5;4;7;8;6;7;8;3;4;6;4;5;4;5;3;5;5;4;4;3;4;4;3;2;3;3;3;6;6;4;5;3;5;4;5;3; GO:0031974;GO:0043231;GO:0043233;GO:0044429;GO:0044424;GO:0044422;GO:0043227;GO:0044446;GO:0044444;GO:0005737;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005759;GO:0043229;GO:0005575;GO:0070013; membrane-enclosed lumen;intracellular membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;organelle part;membrane-bounded organelle;intracellular organelle part;cytoplasmic part;cytoplasm;mitochondrion;cell part;cell;intracellular;organelle;mitochondrial matrix;intracellular organelle;cellular_component;intracellular organelle lumen; 2;4;3;4;3;2;3;3;4;4;5;2;2;3;2;5;3;1;4; GO:0051287;GO:0016597;GO:1901363;GO:0070728;GO:0000166;GO:0043531;GO:0097367;GO:0004352;GO:0003674;GO:0005488;GO:0032549;GO:0017076;GO:0005524;GO:0005525;GO:0043168;GO:0003824;GO:0097159;GO:0031406;GO:0019001;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043169;GO:0043167;GO:0032561;GO:0048037;GO:0030554;GO:0043177;GO:0004353;GO:0042802;GO:0005515;GO:0001883;GO:0001882;GO:0050662;GO:1901265;GO:0032559;GO:0036094;GO:0016638;GO:0016639;GO:0070403;GO:0016491; NAD binding;amino acid binding;heterocyclic compound binding;leucine binding;nucleotide binding;ADP binding;carbohydrate derivative binding;glutamate dehydrogenase (NAD+) activity;molecular_function;binding;ribonucleoside binding;purine nucleotide binding;ATP binding;GTP binding;anion binding;catalytic activity;organic cyclic compound binding;carboxylic acid binding;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;cation binding;ion binding;guanyl ribonucleotide binding;cofactor binding;adenyl nucleotide binding;organic acid binding;glutamate dehydrogenase [NAD(P)+] activity;identical protein binding;protein binding;purine nucleoside binding;nucleoside binding;coenzyme binding;nucleoside phosphate binding;adenyl ribonucleotide binding;small molecule binding;oxidoreductase activity, acting on the CH-NH2 group of donors;oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor;NAD+ binding;oxidoreductase activity; 5;6;3;5;4;5;3;6;1;2;5;5;6;6;4;2;3;5;6;5;6;4;5;4;3;6;3;6;4;6;4;3;5;4;4;4;6;3;4;5;5;3; K00261 map00220;map00250;map00471;map00910;map01100;map01200;map04964; Arginine biosynthesis;"Alanine, aspartate and glutamate metabolism";D-Glutamine and D-glutamate metabolism;Nitrogen metabolism;Metabolic pathways;Carbon metabolism;Proximal tubule bicarbonate reclamation; IPR006097;IPR006096;IPR006095;IPR033922;IPR033524;IPR016040; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain;Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal;Glutamate/phenylalanine/leucine/valine dehydrogenase;NAD(P) binding domain of glutamate dehydrogenase;Leu/Phe/Val dehydrogenases active site;NAD(P)-binding domain; mitochondria Hs4885281 1157.0 E [E] Amino acid transport and metabolism; P54108 Cysteine-rich secretory protein 3 OS=Homo sapiens OX=9606 GN=CRISP3 PE=1 SV=1 - [CRIS3_HUMAN] 1 0.885 1.255 1.049 0.952 0.979 1.129943503 0.359229341 1.101890756 0.045664753 1.418079096 0.075922558 1.028361345 0.821967514 GO:0002376;GO:0045087;GO:0006952;GO:0006950;GO:0008150;GO:0006955;GO:0050896; immune system process;innate immune response;defense response;response to stress;biological_process;immune response;response to stimulus; 2;4;4;3;1;3;2; GO:0031012;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0016023;GO:0031410;GO:0031988;GO:0005615;GO:0099503;GO:0030141;GO:0012505;GO:1903561;GO:0031982;GO:0042581;GO:0043230;GO:0043231;GO:0005578;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421;GO:0097708; extracellular matrix;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;membrane-bounded vesicle;extracellular space;secretory vesicle;secretory granule;endomembrane system;extracellular vesicle;vesicle;specific granule;extracellular organelle;intracellular membrane-bounded organelle;proteinaceous extracellular matrix;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part;intracellular vesicle; 2;3;3;2;4;4;5;5;5;3;6;4;3;3;4;5;3;4;3;2;2;3;1;4;2;3;2;4; K19919 IPR001283;IPR018244;IPR013871;IPR014044;IPR003582;IPR034117; Cysteine-rich secretory protein, allergen V5/Tpx-1-related;Allergen V5/Tpx-1-related, conserved site;Cysteine-rich secretory protein;CAP domain;ShKT domain;Cysteine-rich secretory protein, SCP domain; extracellular Hs5174675 511.0 S [S] Function unknown; O95395 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 OS=Homo sapiens OX=9606 GN=GCNT3 PE=2 SV=1 - [GCNT3_HUMAN] 1.19 1.128 0.591 1.373 1.085 0.887 1.054964539 0.376478868 1.265437788 0.065865152 0.52393617 0.010074774 0.817511521 0.107356133 GO:0002381;GO:0002385;GO:0044710;GO:0001822;GO:0048513;GO:0060993;GO:0003008;GO:0044707;GO:0019538;GO:0002426;GO:0002376;GO:0002377;GO:0022600;GO:0044267;GO:0044260;GO:0009887;GO:0016266;GO:0006810;GO:0009888;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0044723;GO:0051234;GO:0050896;GO:0044765;GO:0050892;GO:0043413;GO:0044763;GO:0044249;GO:0034645;GO:0009653;GO:0044699;GO:0016064;GO:0032502;GO:0032501;GO:0043687;GO:0009987;GO:0001655;GO:0006493;GO:0072001;GO:0002460;GO:1901137;GO:1901135;GO:0043170;GO:0048731;GO:0019724;GO:0009100;GO:0009101;GO:0006486;GO:0007275;GO:0071704;GO:0048729;GO:1901576;GO:0007586;GO:0070085;GO:0006464;GO:0044767;GO:0002449;GO:0009058;GO:0009059;GO:0002440;GO:0002443;GO:0051179;GO:1902578;GO:0044238;GO:0005975;GO:0048856;GO:0044237;GO:0002251;GO:0002250;GO:0002252; immunoglobulin production involved in immunoglobulin mediated immune response;mucosal immune response;single-organism metabolic process;kidney development;animal organ development;kidney morphogenesis;system process;single-multicellular organism process;protein metabolic process;immunoglobulin production in mucosal tissue;immune system process;immunoglobulin production;digestive system process;cellular protein metabolic process;cellular macromolecule metabolic process;organ morphogenesis;O-glycan processing;transport;tissue development;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;single-organism carbohydrate metabolic process;establishment of localization;response to stimulus;single-organism transport;intestinal absorption;macromolecule glycosylation;single-organism cellular process;cellular biosynthetic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;single-organism process;immunoglobulin mediated immune response;developmental process;multicellular organismal process;post-translational protein modification;cellular process;urogenital system development;protein O-linked glycosylation;renal system development;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;system development;B cell mediated immunity;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;multicellular organism development;organic substance metabolic process;tissue morphogenesis;organic substance biosynthetic process;digestion;glycosylation;cellular protein modification process;single-organism developmental process;lymphocyte mediated immunity;biosynthetic process;macromolecule biosynthetic process;production of molecular mediator of immune response;leukocyte mediated immunity;localization;single-organism localization;primary metabolic process;carbohydrate metabolic process;anatomical structure development;cellular metabolic process;organ or tissue specific immune response;adaptive immune response;immune effector process; 5;5;3;4;4;5;3;3;4;6;2;4;4;5;4;4;6;4;4;5;5;1;2;3;4;3;2;4;4;6;3;4;5;3;2;7;2;2;7;2;5;5;5;5;5;4;4;4;6;5;6;4;4;3;4;4;4;5;6;3;5;3;5;3;4;2;3;3;4;3;3;4;4;3; GO:0031982;GO:0016021;GO:0016020;GO:0005794;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0031224;GO:0012505;GO:0000139;GO:0044446;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0070062;GO:0044444;GO:0044425;GO:1903561;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;Golgi apparatus;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;intrinsic component of membrane;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasm;organelle membrane;cell part;cell;extracellular exosome;cytoplasmic part;membrane part;extracellular vesicle;cellular_component;extracellular region; 4;4;2;4;4;3;4;3;2;2;3;3;3;2;4;3;3;5;3;4;3;2;2;4;4;2;3;1;2; GO:0008109;GO:0008375;GO:0016740;GO:0016757;GO:0016758;GO:0003674;GO:0003824;GO:0003829;GO:0047225;GO:0008194; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;acetylglucosaminyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;transferase activity, transferring hexosyl groups;molecular_function;catalytic activity;beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;UDP-glycosyltransferase activity; 7;6;3;4;5;1;2;7;7;5; K09662 map00512;map01100; Mucin type O-Glycan biosynthesis;Metabolic pathways; IPR003406; Glycosyl transferase, family 14; mitochondria Hs4758422 922.0 G [G] Carbohydrate transport and metabolism; P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2 - [3HIDH_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:1901564;GO:0034641;GO:0006807;GO:0044282;GO:0044710;GO:0006082;GO:0006520;GO:0071704;GO:1901575;GO:1901605;GO:1901606;GO:0044712;GO:0009083;GO:0044238;GO:0009063;GO:0009987;GO:0008150;GO:0019752;GO:0008152;GO:0043436;GO:0044763;GO:0006574;GO:0009056;GO:1901565;GO:0044248;GO:0044699;GO:0006573;GO:0016054;GO:0044237;GO:0046395;GO:0009081;GO:0044281; organonitrogen compound metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;small molecule catabolic process;single-organism metabolic process;organic acid metabolic process;cellular amino acid metabolic process;organic substance metabolic process;organic substance catabolic process;alpha-amino acid metabolic process;alpha-amino acid catabolic process;single-organism catabolic process;branched-chain amino acid catabolic process;primary metabolic process;cellular amino acid catabolic process;cellular process;biological_process;carboxylic acid metabolic process;metabolic process;oxoacid metabolic process;single-organism cellular process;valine catabolic process;catabolic process;organonitrogen compound catabolic process;cellular catabolic process;single-organism process;valine metabolic process;organic acid catabolic process;cellular metabolic process;carboxylic acid catabolic process;branched-chain amino acid metabolic process;small molecule metabolic process; 4;4;3;5;3;4;4;3;4;5;6;4;6;3;5;2;1;6;2;5;3;7;3;5;4;2;6;5;3;6;5;4; GO:0031974;GO:0043226;GO:0043227;GO:0005737;GO:0005623;GO:0005739;GO:0005759;GO:0044446;GO:0043231;GO:0043233;GO:0044464;GO:0043229;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044429;GO:0044424;GO:0044422; membrane-enclosed lumen;organelle;membrane-bounded organelle;cytoplasm;cell;mitochondrion;mitochondrial matrix;intracellular organelle part;intracellular membrane-bounded organelle;organelle lumen;cell part;intracellular organelle;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;mitochondrial part;intracellular part;organelle part; 2;2;3;4;2;5;5;3;4;3;2;3;3;1;4;4;4;3;2; GO:0051287;GO:0003674;GO:0005488;GO:1901363;GO:1901265;GO:0016491;GO:0050662;GO:0008442;GO:0000166;GO:0004616;GO:0036094;GO:0003824;GO:0016614;GO:0016616;GO:0097159;GO:0048037; NAD binding;molecular_function;binding;heterocyclic compound binding;nucleoside phosphate binding;oxidoreductase activity;coenzyme binding;3-hydroxyisobutyrate dehydrogenase activity;nucleotide binding;phosphogluconate dehydrogenase (decarboxylating) activity;small molecule binding;catalytic activity;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;organic cyclic compound binding;cofactor binding; 5;1;2;3;4;3;4;6;4;6;3;2;4;5;3;3; K00020 map00280;map01100; "Valine, leucine and isoleucine degradation";Metabolic pathways; IPR013328;IPR011548;IPR008927;IPR002204;IPR029154;IPR015815;IPR006115;IPR016040; 6-phosphogluconate dehydrogenase, domain 2;3-hydroxyisobutyrate dehydrogenase;6-phosphogluconate dehydrogenase C-terminal domain-like;3-hydroxyisobutyrate dehydrogenase-related, conserved site;3-hydroxyisobutyrate dehydrogenase, NAD-binding domain;3-hydroxyisobutyrate dehydrogenase-related;6-phosphogluconate dehydrogenase, NADP-binding;NAD(P)-binding domain; mitochondria Hs20539653 687.0 R [R] General function prediction only; Q92954 Proteoglycan 4 OS=Homo sapiens OX=9606 GN=PRG4 PE=1 SV=3 - [PRG4_HUMAN] 0.936 0.882 1.452 0.92 0.92 1.032 1.06122449 0.805941998 1 0.743923324 1.646258503 0.004469315 1.12173913 0.140519242 GO:0002376;GO:0008283;GO:0050896;GO:0006955;GO:0008150;GO:0044699; immune system process;cell proliferation;response to stimulus;immune response;biological_process;single-organism process; 2;3;2;3;1;2; GO:0005575;GO:0005576; cellular_component;extracellular region; 1;2; GO:0038024;GO:0005044;GO:0030247;GO:0030246;GO:0060089;GO:0003674;GO:0004872;GO:0001871;GO:0005488; cargo receptor activity;scavenger receptor activity;polysaccharide binding;carbohydrate binding;molecular transducer activity;molecular_function;receptor activity;pattern binding;binding; 4;5;4;3;2;1;3;3;2; IPR018487;IPR018486;IPR000585;IPR020436;IPR001212; Hemopexin-like repeats;Hemopexin, conserved site;Hemopexin-like domain;Somatomedin B, chordata;Somatomedin B domain; extracellular 330470636 58.9 S [S] Function unknown; COG4223 Uncharacterized conserved protein Q9Y575 Ankyrin repeat and SOCS box protein 3 OS=Homo sapiens OX=9606 GN=ASB3 PE=1 SV=1 - [ASB3_HUMAN] 1.18 1.246 0.722 0.802 1.233 1.088 0.947030498 nan 0.650446067 nan 0.579454254 nan 0.882400649 nan GO:0023052;GO:0007165;GO:0035556;GO:0050789;GO:0044699;GO:0044267;GO:0051716;GO:0044260;GO:0071704;GO:0070647;GO:0032446;GO:0065007;GO:0044700;GO:0009987;GO:0006464;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0007154;GO:0044238;GO:0019538;GO:0050896;GO:0044237;GO:0043170;GO:0016567;GO:0044763; signaling;signal transduction;intracellular signal transduction;regulation of biological process;single-organism process;cellular protein metabolic process;cellular response to stimulus;cellular macromolecule metabolic process;organic substance metabolic process;protein modification by small protein conjugation or removal;protein modification by small protein conjugation;biological regulation;single organism signaling;cellular process;cellular protein modification process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;cell communication;primary metabolic process;protein metabolic process;response to stimulus;cellular metabolic process;macromolecule metabolic process;protein ubiquitination;single-organism cellular process; 2;4;5;2;2;5;3;4;3;7;8;2;3;2;6;3;5;5;1;2;4;3;4;2;3;4;9;3; GO:0005622;GO:0005623;GO:0044464;GO:0005575; intracellular;cell;cell part;cellular_component; 3;2;2;1; K10325 IPR001496;IPR002110;IPR020683; SOCS box domain;Ankyrin repeat;Ankyrin repeat-containing domain; cytoskeleton Hs7705831 1075.0 R [R] General function prediction only; O43812 Double homeobox protein 1 OS=Homo sapiens OX=9606 GN=DUX1 PE=1 SV=1 - [DUX1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:0043170;GO:1901360;GO:0032774;GO:0044260;GO:0050789;GO:1901362;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0010468;GO:0018130;GO:1901576;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0034645;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0034641;GO:0006355;GO:0010556;GO:0006351;GO:0019438;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;cellular macromolecule metabolic process;regulation of biological process;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of gene expression;heterocycle biosynthetic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;cellular macromolecule biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular nitrogen compound metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process; 4;3;5;4;4;5;4;3;4;4;6;4;2;5;6;3;5;2;7;5;5;4;5;4;2;4;7;3;3;5;5;1;4;2;6;5;4;5;3;5;4;5;4;6;5;6;5;3; GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043565;GO:1901363;GO:0097159; molecular_function;binding;nucleic acid binding;DNA binding;sequence-specific DNA binding;heterocyclic compound binding;organic cyclic compound binding; 1;2;4;5;6;3;3; IPR000047;IPR017970;IPR001356;IPR009057; Helix-turn-helix motif;Homeobox, conserved site;Homeobox domain;Homeobox domain-like; nucleus Hs11120736 342.0 K [K] Transcription; P62079 Tetraspanin-5 OS=Homo sapiens OX=9606 GN=TSPAN5 PE=1 SV=1 - [TSN5_HUMAN] 1.037 1.673 0.629 0.978 1.043 0.75 0.619844591 nan 0.93767977 nan 0.375971309 nan 0.719079578 nan GO:0008104;GO:0051234;GO:0044700;GO:0048584;GO:0048583;GO:0023056;GO:0061024;GO:0007009;GO:0023052;GO:0007165;GO:0007166;GO:0023051;GO:0071840;GO:0010647;GO:0010646;GO:0044802;GO:0050789;GO:0051716;GO:0007219;GO:0045747;GO:0009966;GO:0009967;GO:0010256;GO:0016043;GO:0090002;GO:0071704;GO:0010467;GO:0065007;GO:0044699;GO:0048518;GO:0022610;GO:0034613;GO:0008283;GO:1990778;GO:0009987;GO:0050794;GO:0045184;GO:0008150;GO:0072657;GO:0008152;GO:0008593;GO:0007155;GO:0007154;GO:0072659;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0033036;GO:0051604;GO:0019538;GO:0090150;GO:0050896;GO:0070727;GO:0044763;GO:0043170;GO:1902580;GO:0048522; protein localization;establishment of localization;single organism signaling;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of signaling;membrane organization;plasma membrane organization;signaling;signal transduction;cell surface receptor signaling pathway;regulation of signaling;cellular component organization or biogenesis;positive regulation of cell communication;regulation of cell communication;single-organism membrane organization;regulation of biological process;cellular response to stimulus;Notch signaling pathway;positive regulation of Notch signaling pathway;regulation of signal transduction;positive regulation of signal transduction;endomembrane system organization;cellular component organization;establishment of protein localization to plasma membrane;organic substance metabolic process;gene expression;biological regulation;single-organism process;positive regulation of biological process;biological adhesion;cellular protein localization;cell proliferation;protein localization to cell periphery;cellular process;regulation of cellular process;establishment of protein localization;biological_process;protein localization to membrane;metabolic process;regulation of Notch signaling pathway;cell adhesion;cell communication;protein localization to plasma membrane;localization;single-organism localization;cellular localization;primary metabolic process;macromolecule localization;protein maturation;protein metabolic process;establishment of protein localization to membrane;response to stimulus;cellular macromolecule localization;single-organism cellular process;macromolecule metabolic process;single-organism cellular localization;positive regulation of cellular process; 4;3;3;3;3;3;4;5;2;4;5;3;2;4;4;4;2;3;6;5;4;4;4;3;6;3;5;2;2;2;2;5;3;6;2;3;4;1;5;2;5;3;4;6;2;3;3;3;3;5;4;5;2;4;3;4;4;3; GO:0044464;GO:0071944;GO:0031224;GO:0016021;GO:0016020;GO:0005886;GO:0005623;GO:0005575;GO:0044425; cell part;cell periphery;intrinsic component of membrane;integral component of membrane;membrane;plasma membrane;cell;cellular_component;membrane part; 2;3;3;4;2;3;2;1;2; K17345 IPR000301;IPR018499;IPR008952;IPR018503; Tetraspanin;Tetraspanin/Peripherin;Tetraspanin, EC2 domain;Tetraspanin, conserved site; plasma membrane Hs21264583 541.0 R [R] General function prediction only; Q96GE4 Centrosomal protein of 95 kDa OS=Homo sapiens OX=9606 GN=CEP95 PE=1 SV=1 - [CEP95_HUMAN] 0.957 1.111 1.066 1.113 0.952 1.03 0.861386139 nan 1.169117647 nan 0.95949595 nan 1.081932773 nan GO:0005737;GO:0005856;GO:0015630;GO:0043232;GO:0005819;GO:0005813;GO:0000922;GO:0044464;GO:0044446;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0043228;GO:0044430;GO:0044424;GO:0005815;GO:0043226;GO:0044422; cytoplasm;cytoskeleton;microtubule cytoskeleton;intracellular non-membrane-bounded organelle;spindle;centrosome;spindle pole;cell part;intracellular organelle part;cell;intracellular;cellular_component;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;intracellular part;microtubule organizing center;organelle;organelle part; 4;5;6;4;5;5;5;2;3;2;3;1;3;3;4;3;5;2;2; K16544 IPR001715;IPR026619; Calponin homology domain;Centrosomal protein of 95kDa; cytosol Q16760 Diacylglycerol kinase delta OS=Homo sapiens OX=9606 GN=DGKD PE=1 SV=4 - [DGKD_HUMAN] 1.059 0.973 0.919 1.159 0.955 1.474 1.088386434 0.019046861 1.213612565 0.04722556 0.944501542 0.610183861 1.543455497 0.379504158 GO:0008104;GO:0007599;GO:0007596;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0051716;GO:0009611;GO:0045184;GO:0007173;GO:0046486;GO:0046339;GO:0010033;GO:0030168;GO:0016192;GO:0044700;GO:0044707;GO:0007186;GO:0007205;GO:0022607;GO:0019932;GO:0035556;GO:0016049;GO:0016043;GO:0065003;GO:0065007;GO:0065008;GO:0006810;GO:0006629;GO:0044710;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0051234;GO:0044767;GO:0006897;GO:0050896;GO:0001775;GO:0070271;GO:0006639;GO:0006638;GO:0023052;GO:0038127;GO:0042221;GO:0044699;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0044255;GO:0051259;GO:0033036;GO:0043933;GO:0007275;GO:0040007;GO:0071822;GO:0051260;GO:0050789;GO:0071704;GO:0071702;GO:0006461;GO:0044763;GO:0007154;GO:0051179;GO:0044238;GO:0048856;GO:0044237;GO:0044085;GO:0015031; protein localization;hemostasis;blood coagulation;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;response to wounding;establishment of protein localization;epidermal growth factor receptor signaling pathway;glycerolipid metabolic process;diacylglycerol metabolic process;response to organic substance;platelet activation;vesicle-mediated transport;single organism signaling;single-multicellular organism process;G-protein coupled receptor signaling pathway;protein kinase C-activating G-protein coupled receptor signaling pathway;cellular component assembly;second-messenger-mediated signaling;intracellular signal transduction;cell growth;cellular component organization;macromolecular complex assembly;biological regulation;regulation of biological quality;transport;lipid metabolic process;single-organism metabolic process;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;establishment of localization;single-organism developmental process;endocytosis;response to stimulus;cell activation;protein complex biogenesis;acylglycerol metabolic process;neutral lipid metabolic process;signaling;ERBB signaling pathway;response to chemical;single-organism process;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;cellular lipid metabolic process;protein oligomerization;macromolecule localization;macromolecular complex subunit organization;multicellular organism development;growth;protein complex subunit organization;protein homooligomerization;regulation of biological process;organic substance metabolic process;organic substance transport;protein complex assembly;single-organism cellular process;cell communication;localization;primary metabolic process;anatomical structure development;cellular metabolic process;cellular component biogenesis;protein transport; 4;5;5;4;5;6;7;2;3;4;4;9;5;7;4;5;5;3;3;5;6;4;6;5;3;3;5;2;3;4;4;3;5;3;3;4;1;2;3;3;6;2;4;4;6;5;2;8;3;2;2;2;4;2;4;6;3;4;4;2;5;7;2;3;5;5;3;4;2;3;3;3;3;5; GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0043226;GO:0097708;GO:0044444;GO:0005737;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005886;GO:0005575; vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;organelle;intracellular vesicle;cytoplasmic part;cytoplasm;cytoplasmic vesicle;cell part;cell;intracellular;cell periphery;plasma membrane;cellular_component; 4;5;2;5;4;3;3;3;2;4;4;4;5;2;2;3;3;3;1; GO:1901363;GO:0016740;GO:0046872;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0004143;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0019992;GO:0032559;GO:0032555;GO:0046983;GO:0046982;GO:0032550;GO:0032553;GO:0035639;GO:0000166;GO:0043169;GO:0043167;GO:0042802;GO:0042803;GO:0008289;GO:0030554;GO:0005515;GO:0097159;GO:0001883;GO:0001882;GO:0036094; heterocyclic compound binding;transferase activity;metal ion binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;diacylglycerol kinase activity;ATP binding;anion binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;diacylglycerol binding;adenyl ribonucleotide binding;purine ribonucleotide binding;protein dimerization activity;protein heterodimerization activity;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;cation binding;ion binding;identical protein binding;protein homodimerization activity;lipid binding;adenyl nucleotide binding;protein binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;small molecule binding; 3;3;5;3;1;2;4;5;5;6;6;4;5;2;5;4;4;6;5;4;5;6;4;5;4;4;3;4;5;3;6;3;3;5;4;3; K00901 map00561;map00564;map01100;map01110;map04070;map04072;map05231; Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Choline metabolism in cancer; IPR002219;IPR013761;IPR017438;IPR001849;IPR001660;IPR016064;IPR000756;IPR001206;IPR011993; Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;Sterile alpha motif/pointed domain;Inorganic polyphosphate/ATP-NAD kinase, domain 1;Pleckstrin homology domain;Sterile alpha motif domain;NAD kinase/diacylglycerol kinase-like domain;Diacylglycerol kinase, accessory domain;Diacylglycerol kinase, catalytic domain;PH domain-like; nucleus Hs4503311 2390.0 I [I] Lipid transport and metabolism; Q9H013 Disintegrin and metalloproteinase domain-containing protein 19 OS=Homo sapiens OX=9606 GN=ADAM19 PE=1 SV=3 - [ADA19_HUMAN] 1.01 1.08 0.977 0.896 1.237 0.925 0.935185185 nan 0.724333064 nan 0.90462963 nan 0.74777688 nan GO:0033619;GO:0043170;GO:0072358;GO:0007275;GO:0071704;GO:0048513;GO:0044699;GO:0006509;GO:0006508;GO:0032502;GO:0032501;GO:0044238;GO:0044767;GO:0008150;GO:0008152;GO:0007507;GO:0044707;GO:0019538;GO:0048856;GO:0072359;GO:0048731; membrane protein proteolysis;macromolecule metabolic process;cardiovascular system development;multicellular organism development;organic substance metabolic process;animal organ development;single-organism process;membrane protein ectodomain proteolysis;proteolysis;developmental process;multicellular organismal process;primary metabolic process;single-organism developmental process;biological_process;metabolic process;heart development;single-multicellular organism process;protein metabolic process;anatomical structure development;circulatory system development;system development; 6;4;5;4;3;4;2;7;5;2;2;3;3;1;2;4;3;4;3;5;4; GO:0031224;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0016021;GO:0016020;GO:0005794;GO:0012505;GO:0044425;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; intrinsic component of membrane;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;integral component of membrane;membrane;Golgi apparatus;endomembrane system;membrane part;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 3;3;3;2;4;4;2;4;3;2;4;2;2;3;1;4;3; GO:0004175;GO:0016787;GO:0003674;GO:0005488;GO:0008233;GO:0043167;GO:0008237;GO:0043169;GO:0046914;GO:0046872;GO:0004222;GO:0003824;GO:0070011;GO:0008270; endopeptidase activity;hydrolase activity;molecular_function;binding;peptidase activity;ion binding;metallopeptidase activity;cation binding;transition metal ion binding;metal ion binding;metalloendopeptidase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides;zinc ion binding; 6;3;1;2;4;3;6;4;6;5;7;2;5;7; K08608 IPR024079;IPR000742;IPR002870;IPR006586;IPR033596;IPR001762;IPR018358;IPR034027;IPR013032;IPR001590; Metallopeptidase, catalytic domain;EGF-like domain;Peptidase M12B, propeptide;ADAM, cysteine-rich;ADAM19 peptidase;Disintegrin domain;Disintegrin, conserved site;Reprolysin domain, adamalysin-type;EGF-like, conserved site;Peptidase M12B, ADAM/reprolysin; plasma membrane Hs15451842 1974.0 O [O] Posttranslational modification, protein turnover, chaperones; O75636 Ficolin-3 OS=Homo sapiens OX=9606 GN=FCN3 PE=1 SV=2 - [FCN3_HUMAN] 0.955 0.914 0.994 0.983 0.953 1.274 1.044857768 0.142627859 1.031479538 0.044555432 1.087527352 0.011012458 1.33683106 0.000865105 GO:0006909;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:1901362;GO:1901360;GO:0044710;GO:0010605;GO:0043207;GO:0009615;GO:0043654;GO:0044419;GO:0019058;GO:0048518;GO:0048519;GO:0046483;GO:0060255;GO:2001141;GO:0051701;GO:0051707;GO:0051704;GO:0009607;GO:0016192;GO:0009605;GO:0030260;GO:0019538;GO:0002376;GO:0019438;GO:0046718;GO:0009892;GO:0009890;GO:0006807;GO:0002253;GO:0050789;GO:1901576;GO:0044260;GO:0002684;GO:0065007;GO:0018130;GO:0050792;GO:0006810;GO:0009889;GO:0050794;GO:0006952;GO:0043903;GO:0043900;GO:0043901;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:0006959;GO:1903901;GO:0016070;GO:0044271;GO:0051607;GO:0050896;GO:0006950;GO:0010556;GO:0006956;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0052126;GO:0044699;GO:0006139;GO:0051234;GO:1903900;GO:0044765;GO:0001867;GO:0008037;GO:0009987;GO:0006725;GO:0098542;GO:0043277;GO:0006897;GO:0046596;GO:0050776;GO:0051253;GO:0051252;GO:0050778;GO:0009059;GO:0043170;GO:0051828;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0046597;GO:0002682;GO:0072376;GO:0071704;GO:0044409;GO:0045934;GO:0019219;GO:0045087;GO:0006910;GO:1902679;GO:0009058;GO:0044764;GO:0044763;GO:0051171;GO:0051172;GO:0051179;GO:1902578;GO:0040011;GO:0044238;GO:0040013;GO:0040012;GO:0052192;GO:0044237;GO:0016032;GO:0002252;GO:0048525;GO:0044403;GO:0051806;GO:0048523; phagocytosis;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;response to external biotic stimulus;response to virus;recognition of apoptotic cell;interspecies interaction between organisms;viral life cycle;positive regulation of biological process;negative regulation of biological process;heterocycle metabolic process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;interaction with host;response to other organism;multi-organism process;response to biotic stimulus;vesicle-mediated transport;response to external stimulus;entry into host cell;protein metabolic process;immune system process;aromatic compound biosynthetic process;viral entry into host cell;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;activation of immune response;regulation of biological process;organic substance biosynthetic process;cellular macromolecule metabolic process;positive regulation of immune system process;biological regulation;heterocycle biosynthetic process;regulation of viral process;transport;regulation of biosynthetic process;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;regulation of multi-organism process;negative regulation of multi-organism process;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;humoral immune response;negative regulation of viral life cycle;RNA metabolic process;cellular nitrogen compound biosynthetic process;defense response to virus;response to stimulus;response to stress;regulation of macromolecule biosynthetic process;complement activation;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;movement in host environment;single-organism process;nucleobase-containing compound metabolic process;establishment of localization;regulation of viral life cycle;single-organism transport;complement activation, lectin pathway;cell recognition;cellular process;cellular aromatic compound metabolic process;defense response to other organism;apoptotic cell clearance;endocytosis;regulation of viral entry into host cell;regulation of immune response;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of immune response;macromolecule biosynthetic process;macromolecule metabolic process;entry into other organism involved in symbiotic interaction;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;negative regulation of viral entry into host cell;regulation of immune system process;protein activation cascade;organic substance metabolic process;entry into host;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;innate immune response;phagocytosis, recognition;negative regulation of RNA biosynthetic process;biosynthetic process;multi-organism cellular process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;localization;single-organism localization;locomotion;primary metabolic process;negative regulation of locomotion;regulation of locomotion;movement in environment of other organism involved in symbiotic interaction;cellular metabolic process;viral process;immune effector process;negative regulation of viral process;symbiosis, encompassing mutualism through parasitism;entry into cell of other organism involved in symbiotic interaction;negative regulation of cellular process; 5;4;3;3;3;5;4;3;4;4;4;6;3;5;2;2;4;4;6;4;3;2;3;5;3;6;4;2;5;6;3;4;3;3;2;4;4;3;2;5;4;4;4;3;4;4;3;3;1;2;3;5;4;5;5;5;4;2;3;5;4;5;6;4;4;4;2;4;3;5;4;5;4;2;4;4;6;6;4;4;5;5;4;5;4;4;5;5;4;4;5;4;3;3;3;5;5;5;4;5;6;3;3;3;4;4;2;3;2;3;3;3;3;3;4;3;4;4;5;3; GO:0043234;GO:0044421;GO:0072562;GO:0005581;GO:0005615;GO:0032991;GO:0005575;GO:0005576; protein complex;extracellular region part;blood microparticle;collagen trimer;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;2;3;4;3;2;1;2; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0003823;GO:0030246;GO:0046872; molecular_function;binding;cation binding;ion binding;antigen binding;carbohydrate binding;metal ion binding; 1;2;4;3;3;3;5; K10104 IPR002181;IPR014716;IPR014715;IPR020837; Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, conserved site; extracellular Hs4504331 612.0 R [R] General function prediction only; Q92499 ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2 - [DDX1_HUMAN] 1.597 0.745 0.728 1.384 0.741 1.247 2.143624161 nan 1.867746289 nan 0.977181208 nan 1.682860999 nan GO:0008104;GO:0000245;GO:0019222;GO:1901362;GO:1901360;GO:0080090;GO:0051716;GO:0006302;GO:0070727;GO:0010608;GO:0043043;GO:0006388;GO:0051704;GO:0032392;GO:0034470;GO:0006281;GO:0060255;GO:0006446;GO:0000394;GO:2001141;GO:0009607;GO:0051707;GO:0010033;GO:0046483;GO:1901564;GO:0044707;GO:0019538;GO:0006355;GO:0000398;GO:0006259;GO:0033554;GO:0019438;GO:0071103;GO:0033036;GO:0022607;GO:0006807;GO:0034660;GO:0009605;GO:0044267;GO:0044260;GO:0016043;GO:0065003;GO:0043331;GO:0065007;GO:0071840;GO:0018130;GO:0009889;GO:0044710;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0016071;GO:0044271;GO:0043207;GO:0050896;GO:0009059;GO:0006351;GO:0009615;GO:0006518;GO:0032774;GO:0044249;GO:0034641;GO:0014070;GO:0034645;GO:1901566;GO:0044699;GO:0006139;GO:0051246;GO:0022618;GO:0022613;GO:0008380;GO:0043330;GO:0032502;GO:0032501;GO:0008033;GO:0032508;GO:0009987;GO:0006725;GO:1903506;GO:0034248;GO:0006974;GO:0043604;GO:0032268;GO:0043603;GO:0051252;GO:0043170;GO:0033365;GO:1901698;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0090305;GO:0034622;GO:0007275;GO:0071826;GO:0006399;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0097659;GO:0010501;GO:0010468;GO:1901576;GO:0019219;GO:0034613;GO:0044767;GO:0000375;GO:0009058;GO:0000377;GO:0044763;GO:0051171;GO:0042221;GO:1903608;GO:0051179;GO:0051641;GO:0006996;GO:0044238;GO:0051276;GO:0048856;GO:0044237;GO:0044085;GO:0006417;GO:0006413;GO:0006412;GO:0006396;GO:0006397; protein localization;spliceosomal complex assembly;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of primary metabolic process;cellular response to stimulus;double-strand break repair;cellular macromolecule localization;posttranscriptional regulation of gene expression;peptide biosynthetic process;tRNA splicing, via endonucleolytic cleavage and ligation;multi-organism process;DNA geometric change;ncRNA processing;DNA repair;regulation of macromolecule metabolic process;regulation of translational initiation;RNA splicing, via endonucleolytic cleavage and ligation;regulation of RNA biosynthetic process;response to biotic stimulus;response to other organism;response to organic substance;heterocycle metabolic process;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;regulation of transcription, DNA-templated;mRNA splicing, via spliceosome;DNA metabolic process;cellular response to stress;aromatic compound biosynthetic process;DNA conformation change;macromolecule localization;cellular component assembly;nitrogen compound metabolic process;ncRNA metabolic process;response to external stimulus;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;response to dsRNA;biological regulation;cellular component organization or biogenesis;heterocycle biosynthetic process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;mRNA metabolic process;cellular nitrogen compound biosynthetic process;response to external biotic stimulus;response to stimulus;macromolecule biosynthetic process;transcription, DNA-templated;response to virus;peptide metabolic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;response to organic cyclic compound;cellular macromolecule biosynthetic process;organonitrogen compound biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;regulation of protein metabolic process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;RNA splicing;response to exogenous dsRNA;developmental process;multicellular organismal process;tRNA processing;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular amide metabolic process;cellular response to DNA damage stimulus;amide biosynthetic process;regulation of cellular protein metabolic process;cellular amide metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;protein localization to organelle;response to nitrogen compound;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;cellular macromolecular complex assembly;multicellular organism development;ribonucleoprotein complex subunit organization;tRNA metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;nucleic acid-templated transcription;RNA secondary structure unwinding;regulation of gene expression;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;cellular protein localization;single-organism developmental process;RNA splicing, via transesterification reactions;biosynthetic process;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;single-organism cellular process;regulation of nitrogen compound metabolic process;response to chemical;protein localization to cytoplasmic stress granule;localization;cellular localization;organelle organization;primary metabolic process;chromosome organization;anatomical structure development;cellular metabolic process;cellular component biogenesis;regulation of translation;translational initiation;translation;RNA processing;mRNA processing; 4;6;3;5;4;4;3;5;4;6;6;9;2;7;7;4;4;5;8;6;3;3;4;4;4;3;4;6;8;5;4;5;6;3;4;3;6;3;5;4;3;5;5;2;2;5;4;3;3;3;1;2;5;5;6;5;4;2;5;6;4;5;6;4;4;5;5;5;2;4;5;5;4;7;6;2;2;8;8;2;4;7;5;5;6;5;5;5;4;6;4;4;5;4;5;6;6;4;5;7;6;2;3;5;5;7;6;5;4;5;5;3;8;3;9;3;4;3;7;2;3;4;3;5;3;3;3;6;4;6;6;7; GO:0035770;GO:0031974;GO:0030529;GO:0071920;GO:0031981;GO:0016020;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:1990904;GO:0043232;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016604;GO:0044446;GO:0044444;GO:0072669;GO:0005737;GO:0005634;GO:0005654;GO:0044451;GO:0010494;GO:0044464;GO:0005623;GO:0043228;GO:0036464;GO:0032991;GO:0005575;GO:0070013; ribonucleoprotein granule;membrane-enclosed lumen;intracellular ribonucleoprotein complex;cleavage body;nuclear lumen;membrane;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear body;intracellular organelle part;cytoplasmic part;tRNA-splicing ligase complex;cytoplasm;nucleus;nucleoplasm;nucleoplasm part;cytoplasmic stress granule;cell part;cell;non-membrane-bounded organelle;cytoplasmic ribonucleoprotein granule;macromolecular complex;cellular_component;intracellular organelle lumen; 5;2;4;7;5;2;3;4;3;4;3;2;3;4;3;3;3;2;6;3;4;4;4;5;5;5;6;2;2;3;5;2;1;4; GO:0004527;GO:0008186;GO:1901363;GO:0003712;GO:0000166;GO:0035639;GO:0097367;GO:0032549;GO:0004386;GO:0016818;GO:0016817;GO:0070035;GO:0033677;GO:0003674;GO:0005488;GO:0016887;GO:0003677;GO:1901265;GO:0042623;GO:0003725;GO:0000989;GO:0000988;GO:0017076;GO:0005524;GO:0016787;GO:0016788;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008026;GO:0008143;GO:0043167;GO:0030554;GO:0004518;GO:0003727;GO:0003724;GO:0003723;GO:0044877;GO:0003682;GO:0003676;GO:0036094;GO:0001883;GO:0001882;GO:0044822;GO:0017111;GO:0004004;GO:0070717;GO:0043168; exonuclease activity;RNA-dependent ATPase activity;heterocyclic compound binding;transcription cofactor activity;nucleotide binding;purine ribonucleoside triphosphate binding;carbohydrate derivative binding;ribonucleoside binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;DNA/RNA helicase activity;molecular_function;binding;ATPase activity;DNA binding;nucleoside phosphate binding;ATPase activity, coupled;double-stranded RNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;purine nucleotide binding;ATP binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-dependent helicase activity;poly(A) binding;ion binding;adenyl nucleotide binding;nuclease activity;single-stranded RNA binding;RNA helicase activity;RNA binding;macromolecular complex binding;chromatin binding;nucleic acid binding;small molecule binding;purine nucleoside binding;nucleoside binding;poly(A) RNA binding;nucleoside-triphosphatase activity;ATP-dependent RNA helicase activity;poly-purine tract binding;anion binding; 6;10;3;4;4;5;3;5;8;5;4;9;9;1;2;8;5;4;9;6;3;2;5;6;3;4;2;3;6;6;5;6;4;10;8;3;6;5;6;9;5;3;4;4;3;5;4;6;7;10;7;4; K13177 IPR014014;IPR011545;IPR003877;IPR001650;IPR013320;IPR001870;IPR014001;IPR027417; RNA helicase, DEAD-box type, Q motif;DEAD/DEAH box helicase domain;SPRY domain;Helicase, C-terminal;Concanavalin A-like lectin/glucanase domain;B30.2/SPRY domain;Helicase superfamily 1/2, ATP-binding domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs4826686 1542.0 A [A] RNA processing and modification; A6NHR9 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2 - [SMHD1_HUMAN] 0.955 1.176 1.008 0.866 0.765 2.415 0.81207483 nan 1.132026144 nan 0.857142857 nan 3.156862745 nan GO:0019222;GO:0009048;GO:0071840;GO:0050789;GO:0040029;GO:0016043;GO:0071704;GO:0010467;GO:0065007;GO:0010468;GO:0060255;GO:0009987;GO:0008150;GO:0008152;GO:0051276;GO:0006996;GO:0007549;GO:0043170;GO:0060821; regulation of metabolic process;dosage compensation by inactivation of X chromosome;cellular component organization or biogenesis;regulation of biological process;regulation of gene expression, epigenetic;cellular component organization;organic substance metabolic process;gene expression;biological regulation;regulation of gene expression;regulation of macromolecule metabolic process;cellular process;biological_process;metabolic process;chromosome organization;organelle organization;dosage compensation;macromolecule metabolic process;inactivation of X chromosome by DNA methylation; 3;8;2;2;6;3;3;5;2;5;4;2;1;2;5;4;7;4;9; GO:0031974;GO:0000803;GO:0043226;GO:0043229;GO:0043228;GO:0000228;GO:0043227;GO:0005575;GO:0031981;GO:0005634;GO:0000805;GO:0001740;GO:0005694;GO:0044428;GO:0005622;GO:0044424;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0044446;GO:0070013;GO:0044422; membrane-enclosed lumen;sex chromosome;organelle;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome;membrane-bounded organelle;cellular_component;nuclear lumen;nucleus;X chromosome;Barr body;chromosome;nuclear part;intracellular;intracellular part;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular organelle part;intracellular organelle lumen;organelle part; 2;6;2;3;3;5;3;1;5;5;7;6;5;4;3;3;4;4;3;2;2;3;4;2; GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0000166;GO:1901265;GO:0001882;GO:0043168;GO:0043167;GO:0001883;GO:0032549;GO:0017076;GO:0005524;GO:0036094;GO:0030554;GO:0097367;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;nucleotide binding;nucleoside phosphate binding;nucleoside binding;anion binding;ion binding;purine nucleoside binding;ribonucleoside binding;purine nucleotide binding;ATP binding;small molecule binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;3;1;2;4;4;4;4;3;5;5;5;6;3;6;3;3;6;5;6;4; K23113 IPR010935;IPR013783;IPR003594; SMCs flexible hinge;Immunoglobulin-like fold;Histidine kinase-like ATPase, C-terminal domain; cytosol Q8NEK8 Terminal nucleotidyltransferase 5D OS=Homo sapiens OX=9606 GN=TENT5D PE=1 SV=1 - [TET5D_HUMAN] 0.962 1.127 0.802 1.093 1.405 0.546 0.853593611 nan 0.777935943 nan 0.71162378 nan 0.3886121 nan K23035 IPR012937; FAM46 family; cytosol, nucleus Hs22055311 808.0 S [S] Function unknown; Q99784 Noelin OS=Homo sapiens OX=9606 GN=OLFM1 PE=1 SV=4 - [NOE1_HUMAN] 0.804 0.945 1.413 0.965 0.914 1.254 0.850793651 nan 1.055798687 nan 1.495238095 nan 1.371991247 nan GO:0048675;GO:2000736;GO:0019222;GO:0048588;GO:2000738;GO:0048468;GO:0072359;GO:0072358;GO:0007165;GO:0061387;GO:0031344;GO:0071840;GO:0051716;GO:0048863;GO:0048864;GO:0010604;GO:0048869;GO:0045664;GO:0048513;GO:0010720;GO:0048518;GO:0048519;GO:0048762;GO:1990138;GO:0060255;GO:0003007;GO:0008361;GO:0060317;GO:0010975;GO:0030516;GO:0044700;GO:0044707;GO:0032535;GO:0022604;GO:0009892;GO:0009893;GO:0022603;GO:0003179;GO:0010628;GO:0031175;GO:0003171;GO:0003170;GO:0050789;GO:0000904;GO:0016049;GO:0000902;GO:0016043;GO:0090066;GO:0048589;GO:0065007;GO:0065008;GO:0048646;GO:0051130;GO:0009887;GO:0061564;GO:0050793;GO:0009888;GO:0050794;GO:0014031;GO:0008150;GO:0008152;GO:0048731;GO:0010605;GO:0010718;GO:0010717;GO:0050896;GO:0051960;GO:0003181;GO:0003188;GO:0048638;GO:0051239;GO:0030154;GO:0051128;GO:0023052;GO:0007154;GO:0009653;GO:0044699;GO:0050767;GO:0051240;GO:0060284;GO:0010769;GO:0003190;GO:0060560;GO:0032502;GO:0032501;GO:0009987;GO:0045597;GO:0045595;GO:0001558;GO:0023041;GO:0007409;GO:0032990;GO:0050770;GO:0051094;GO:0010629;GO:0043170;GO:0010770;GO:0030030;GO:0007275;GO:0040008;GO:0032989;GO:0071704;GO:0010467;GO:0048812;GO:0010468;GO:0048666;GO:0048667;GO:0030182;GO:0044767;GO:0044763;GO:0060485;GO:0022008;GO:0040007;GO:0007507;GO:0048699;GO:0048858;GO:0007399;GO:0048856;GO:0001837;GO:2000026;GO:0048522; axon extension;regulation of stem cell differentiation;regulation of metabolic process;developmental cell growth;positive regulation of stem cell differentiation;cell development;circulatory system development;cardiovascular system development;signal transduction;regulation of extent of cell growth;regulation of cell projection organization;cellular component organization or biogenesis;cellular response to stimulus;stem cell differentiation;stem cell development;positive regulation of macromolecule metabolic process;cellular developmental process;regulation of neuron differentiation;animal organ development;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;mesenchymal cell differentiation;neuron projection extension;regulation of macromolecule metabolic process;heart morphogenesis;regulation of cell size;cardiac epithelial to mesenchymal transition;regulation of neuron projection development;regulation of axon extension;single organism signaling;single-multicellular organism process;regulation of cellular component size;regulation of cell morphogenesis;negative regulation of metabolic process;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;heart valve morphogenesis;positive regulation of gene expression;neuron projection development;atrioventricular valve development;heart valve development;regulation of biological process;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;cellular component organization;regulation of anatomical structure size;developmental growth;biological regulation;regulation of biological quality;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;organ morphogenesis;axon development;regulation of developmental process;tissue development;regulation of cellular process;mesenchymal cell development;biological_process;metabolic process;system development;negative regulation of macromolecule metabolic process;positive regulation of epithelial to mesenchymal transition;regulation of epithelial to mesenchymal transition;response to stimulus;regulation of nervous system development;atrioventricular valve morphogenesis;heart valve formation;regulation of developmental growth;regulation of multicellular organismal process;cell differentiation;regulation of cellular component organization;signaling;cell communication;anatomical structure morphogenesis;single-organism process;regulation of neurogenesis;positive regulation of multicellular organismal process;regulation of cell development;regulation of cell morphogenesis involved in differentiation;atrioventricular valve formation;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;regulation of cell growth;neuronal signal transduction;axonogenesis;cell part morphogenesis;regulation of axonogenesis;positive regulation of developmental process;negative regulation of gene expression;macromolecule metabolic process;positive regulation of cell morphogenesis involved in differentiation;cell projection organization;multicellular organism development;regulation of growth;cellular component morphogenesis;organic substance metabolic process;gene expression;neuron projection morphogenesis;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;single-organism developmental process;single-organism cellular process;mesenchyme development;neurogenesis;growth;heart development;generation of neurons;cell projection morphogenesis;nervous system development;anatomical structure development;epithelial to mesenchymal transition;regulation of multicellular organismal development;positive regulation of cellular process; 6;5;3;4;5;4;5;5;4;5;5;2;3;6;5;4;4;7;4;5;2;2;6;5;4;5;5;6;6;5;3;3;4;5;3;3;4;4;5;5;5;4;2;5;3;5;3;4;3;2;3;3;4;4;6;3;4;3;6;1;2;4;4;4;5;2;5;5;4;4;3;5;4;2;4;3;2;6;3;5;6;5;4;2;2;2;4;4;4;5;7;5;7;3;5;4;5;4;4;3;4;3;5;6;5;5;6;6;3;3;5;6;2;4;7;5;5;3;6;4;3; GO:0005783;GO:0030426;GO:0030424;GO:0097458;GO:0030427;GO:0044297;GO:0044295;GO:0036477;GO:0042995;GO:0043231;GO:0044424;GO:0044421;GO:0043227;GO:0030054;GO:0043025;GO:0012505;GO:0043204;GO:0044444;GO:0043226;GO:0005737;GO:0043005;GO:0044463;GO:0044464;GO:0005623;GO:0043229;GO:0045202;GO:0005615;GO:0005622;GO:0033267;GO:0005575;GO:0005576; endoplasmic reticulum;growth cone;axon;neuron part;site of polarized growth;cell body;axonal growth cone;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;intracellular part;extracellular region part;membrane-bounded organelle;cell junction;neuronal cell body;endomembrane system;perikaryon;cytoplasmic part;organelle;cytoplasm;neuron projection;cell projection part;cell part;cell;intracellular organelle;synapse;extracellular space;intracellular;axon part;cellular_component;extracellular region; 4;4;5;3;3;3;5;4;3;4;3;2;3;2;4;3;4;4;2;4;4;3;2;2;3;2;3;3;4;1;2; IPR022082;IPR031217;IPR011044;IPR015943;IPR003112; Noelin domain;Noelin;Quinoprotein amine dehydrogenase, beta chain-like;WD40/YVTN repeat-like-containing domain;Olfactomedin-like domain; extracellular Hs17136143 920.0 W [W] Extracellular structures; Q9H019 Mitochondrial fission regulator 1-like OS=Homo sapiens OX=9606 GN=MTFR1L PE=1 SV=2 - [MFR1L_HUMAN] 1.377 0.722 1.122 1.018 1.177 nan 1.907202216 nan 0.86491079 nan 1.554016621 nan nan nan GO:0000266;GO:0009060;GO:0006091;GO:0044699;GO:0044710;GO:0071840;GO:0016043;GO:0007005;GO:0045333;GO:0009987;GO:0044763;GO:0008152;GO:0055114;GO:0006996;GO:0015980;GO:0044237;GO:0048285;GO:0008150; mitochondrial fission;aerobic respiration;generation of precursor metabolites and energy;single-organism process;single-organism metabolic process;cellular component organization or biogenesis;cellular component organization;mitochondrion organization;cellular respiration;cellular process;single-organism cellular process;metabolic process;oxidation-reduction process;organelle organization;energy derivation by oxidation of organic compounds;cellular metabolic process;organelle fission;biological_process; 6;6;4;2;3;2;3;5;5;2;3;2;4;4;4;3;5;1; GO:0043229;GO:0005739;GO:0043227;GO:0043226;GO:0005737;GO:0005623;GO:0043231;GO:0044464;GO:0005622;GO:0005575;GO:0044444;GO:0044424; intracellular organelle;mitochondrion;membrane-bounded organelle;organelle;cytoplasm;cell;intracellular membrane-bounded organelle;cell part;intracellular;cellular_component;cytoplasmic part;intracellular part; 3;5;3;2;4;2;4;2;3;1;4;3; IPR007972; Mitochondrial fission regulator 1; mitochondria A0A0C4DH73 Immunoglobulin kappa variable 1-12 OS=Homo sapiens OX=9606 GN=IGKV1-12 PE=3 SV=1 - [KV112_HUMAN] 1.351 1.06 0.702 1.177 1.079 0.726 1.274528302 0.006079289 1.090824838 0.897291205 0.662264151 0.017643453 0.672845227 0.002143036 IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q15800 Methylsterol monooxygenase 1 OS=Homo sapiens OX=9606 GN=MSMO1 PE=1 SV=1 - [MSMO1_HUMAN] 1.101 0.737 1.495 0.962 0.754 1.052 1.493894166 nan 1.275862069 nan 2.028493894 nan 1.395225464 nan GO:0006633;GO:0006631;GO:0019752;GO:0044249;GO:0016125;GO:0044281;GO:0044283;GO:0072330;GO:0044699;GO:1901576;GO:0044710;GO:0044711;GO:0006066;GO:1901362;GO:0071704;GO:1902652;GO:0008203;GO:0046165;GO:0006694;GO:0016126;GO:0006629;GO:0009987;GO:0032787;GO:1902653;GO:0009058;GO:0008150;GO:0008152;GO:0043436;GO:0044255;GO:0008202;GO:0008610;GO:0044238;GO:0006082;GO:0046394;GO:0016053;GO:0044237;GO:0006695;GO:0044763;GO:1901360;GO:1901617;GO:1901615; fatty acid biosynthetic process;fatty acid metabolic process;carboxylic acid metabolic process;cellular biosynthetic process;sterol metabolic process;small molecule metabolic process;small molecule biosynthetic process;monocarboxylic acid biosynthetic process;single-organism process;organic substance biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;alcohol metabolic process;organic cyclic compound biosynthetic process;organic substance metabolic process;secondary alcohol metabolic process;cholesterol metabolic process;alcohol biosynthetic process;steroid biosynthetic process;sterol biosynthetic process;lipid metabolic process;cellular process;monocarboxylic acid metabolic process;secondary alcohol biosynthetic process;biosynthetic process;biological_process;metabolic process;oxoacid metabolic process;cellular lipid metabolic process;steroid metabolic process;lipid biosynthetic process;primary metabolic process;organic acid metabolic process;carboxylic acid biosynthetic process;organic acid biosynthetic process;cellular metabolic process;cholesterol biosynthetic process;single-organism cellular process;organic cyclic compound metabolic process;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process; 6;5;6;4;6;4;5;7;2;4;3;4;5;5;3;6;7;6;6;7;4;2;7;7;3;1;2;5;4;5;5;3;4;6;5;3;8;3;4;5;4; GO:0016020;GO:0005783;GO:0005886;GO:0005789;GO:0043229;GO:0043227;GO:0005737;GO:0005623;GO:0016021;GO:0043226;GO:0031224;GO:0098588;GO:0044446;GO:0012505;GO:0044425;GO:0044432;GO:0043231;GO:0042175;GO:0044464;GO:0005622;GO:0005575;GO:0044444;GO:0071944;GO:0031090;GO:0044424;GO:0044422; membrane;endoplasmic reticulum;plasma membrane;endoplasmic reticulum membrane;intracellular organelle;membrane-bounded organelle;cytoplasm;cell;integral component of membrane;organelle;intrinsic component of membrane;bounding membrane of organelle;intracellular organelle part;endomembrane system;membrane part;endoplasmic reticulum part;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;cell part;intracellular;cellular_component;cytoplasmic part;cell periphery;organelle membrane;intracellular part;organelle part; 2;4;3;3;3;3;4;2;4;2;3;4;3;3;2;4;4;3;2;3;1;4;3;3;3;2; GO:0004497;GO:0003674;GO:0043167;GO:0016491;GO:0046914;GO:0016709;GO:0016705;GO:0005506;GO:0000254;GO:0043169;GO:0003824;GO:0005488;GO:0046872; monooxygenase activity;molecular_function;ion binding;oxidoreductase activity;transition metal ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;iron ion binding;C-4 methylsterol oxidase activity;cation binding;catalytic activity;binding;metal ion binding; 4;1;3;3;6;5;4;7;6;4;2;2;5; K07750 map00100;map01100;map01130; Steroid biosynthesis;Metabolic pathways;Biosynthesis of antibiotics; IPR006694; Fatty acid hydroxylase; extracellular Hs5803157 612.0 I [I] Lipid transport and metabolism; Q92796 Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2 - [DLG3_HUMAN] 1.202 1.089 0.731 1.236 1.01 0.95 1.103764922 0.355547561 1.223762376 0.182699742 0.671258035 0.303632722 0.940594059 0.053263908 GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0006470;GO:0009167;GO:0007163;GO:0007164;GO:0044281;GO:0009161;GO:1901360;GO:0002009;GO:0044710;GO:0010605;GO:0042330;GO:0048869;GO:0044092;GO:0048519;GO:0033036;GO:0042127;GO:0030154;GO:0006935;GO:0044700;GO:0060255;GO:0048468;GO:0046037;GO:0051668;GO:0046128;GO:0009179;GO:0046483;GO:1901564;GO:0009605;GO:0044707;GO:0061024;GO:0019538;GO:0006163;GO:0098916;GO:0019637;GO:0009892;GO:0046710;GO:0045197;GO:0006928;GO:0097120;GO:0006807;GO:0031175;GO:0044802;GO:0050789;GO:0044267;GO:0035088;GO:0000904;GO:0051346;GO:0044260;GO:0009126;GO:0016043;GO:0043086;GO:1901068;GO:0065007;GO:0044699;GO:0065009;GO:0061564;GO:0050790;GO:0009888;GO:0009150;GO:0007268;GO:0035308;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0035303;GO:0050794;GO:0035305;GO:0035304;GO:0051336;GO:0044767;GO:0031400;GO:0070727;GO:0007411;GO:0035418;GO:0048812;GO:0044763;GO:0006753;GO:0099536;GO:0099537;GO:0010563;GO:0016311;GO:0010921;GO:0010923;GO:0034641;GO:0023052;GO:0007154;GO:0061245;GO:0009653;GO:0009259;GO:0006139;GO:0051248;GO:0042278;GO:0051246;GO:0001736;GO:0022008;GO:0031399;GO:0051641;GO:0032502;GO:0008285;GO:0032501;GO:0009987;GO:0006725;GO:0007409;GO:0009132;GO:0009135;GO:0055086;GO:0048858;GO:0032269;GO:0032268;GO:1901135;GO:0043170;GO:0048731;GO:0050896;GO:0009185;GO:0030030;GO:0031324;GO:0031323;GO:0019693;GO:0071840;GO:0072521;GO:0009123;GO:0007275;GO:0008283;GO:0032989;GO:0071704;GO:0097485;GO:0048729;GO:0048666;GO:0048667;GO:0060429;GO:0030182;GO:0045936;GO:0034613;GO:0006464;GO:0051174;GO:0001738;GO:0009117;GO:0009116;GO:0007267;GO:0042221;GO:0009119;GO:0051179;GO:1902578;GO:0000902;GO:0040011;GO:0044238;GO:0048699;GO:0032990;GO:0007399;GO:0048856;GO:0044237;GO:1901657;GO:0006796;GO:0006793;GO:0043113;GO:1902580;GO:0048523;GO:0072657; protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;purine ribonucleoside monophosphate metabolic process;establishment or maintenance of cell polarity;establishment of tissue polarity;small molecule metabolic process;ribonucleoside monophosphate metabolic process;organic cyclic compound metabolic process;morphogenesis of an epithelium;single-organism metabolic process;negative regulation of macromolecule metabolic process;taxis;cellular developmental process;negative regulation of molecular function;negative regulation of biological process;macromolecule localization;regulation of cell proliferation;cell differentiation;chemotaxis;single organism signaling;regulation of macromolecule metabolic process;cell development;GMP metabolic process;localization within membrane;purine ribonucleoside metabolic process;purine ribonucleoside diphosphate metabolic process;heterocycle metabolic process;organonitrogen compound metabolic process;response to external stimulus;single-multicellular organism process;membrane organization;protein metabolic process;purine nucleotide metabolic process;anterograde trans-synaptic signaling;organophosphate metabolic process;negative regulation of metabolic process;GDP metabolic process;establishment or maintenance of epithelial cell apical/basal polarity;movement of cell or subcellular component;receptor localization to synapse;nitrogen compound metabolic process;neuron projection development;single-organism membrane organization;regulation of biological process;cellular protein metabolic process;establishment or maintenance of apical/basal cell polarity;cell morphogenesis involved in differentiation;negative regulation of hydrolase activity;cellular macromolecule metabolic process;purine nucleoside monophosphate metabolic process;cellular component organization;negative regulation of catalytic activity;guanosine-containing compound metabolic process;biological regulation;single-organism process;regulation of molecular function;axon development;regulation of catalytic activity;tissue development;purine ribonucleotide metabolic process;synaptic transmission;negative regulation of protein dephosphorylation;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of dephosphorylation;regulation of cellular process;negative regulation of dephosphorylation;regulation of protein dephosphorylation;regulation of hydrolase activity;single-organism developmental process;negative regulation of protein modification process;cellular macromolecule localization;axon guidance;protein localization to synapse;neuron projection morphogenesis;single-organism cellular process;nucleoside phosphate metabolic process;synaptic signaling;trans-synaptic signaling;negative regulation of phosphorus metabolic process;dephosphorylation;regulation of phosphatase activity;negative regulation of phosphatase activity;cellular nitrogen compound metabolic process;signaling;cell communication;establishment or maintenance of bipolar cell polarity;anatomical structure morphogenesis;ribonucleotide metabolic process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;purine nucleoside metabolic process;regulation of protein metabolic process;establishment of planar polarity;neurogenesis;regulation of protein modification process;cellular localization;developmental process;negative regulation of cell proliferation;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;axonogenesis;nucleoside diphosphate metabolic process;purine nucleoside diphosphate metabolic process;nucleobase-containing small molecule metabolic process;cell projection morphogenesis;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;carbohydrate derivative metabolic process;macromolecule metabolic process;system development;response to stimulus;ribonucleoside diphosphate metabolic process;cell projection organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;ribose phosphate metabolic process;cellular component organization or biogenesis;purine-containing compound metabolic process;nucleoside monophosphate metabolic process;multicellular organism development;cell proliferation;cellular component morphogenesis;organic substance metabolic process;neuron projection guidance;tissue morphogenesis;neuron development;cell morphogenesis involved in neuron differentiation;epithelium development;neuron differentiation;negative regulation of phosphate metabolic process;cellular protein localization;cellular protein modification process;regulation of phosphorus metabolic process;morphogenesis of a polarized epithelium;nucleotide metabolic process;nucleoside metabolic process;cell-cell signaling;response to chemical;ribonucleoside metabolic process;localization;single-organism localization;cell morphogenesis;locomotion;primary metabolic process;generation of neurons;cell part morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;glycosyl compound metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;receptor clustering;single-organism cellular localization;negative regulation of cellular process;protein localization to membrane; 4;6;4;3;7;8;4;4;4;7;4;5;3;4;3;4;4;2;3;4;5;4;3;4;4;8;4;7;8;4;4;3;3;4;4;6;7;4;3;8;7;4;6;3;5;4;2;5;6;5;6;4;7;3;5;8;2;2;3;6;4;4;7;8;7;5;5;1;2;7;3;7;7;5;3;6;4;6;5;6;3;5;5;6;5;6;6;7;4;2;4;5;3;6;4;5;6;5;5;6;6;3;2;4;2;2;4;7;6;7;4;5;5;5;4;4;4;2;7;4;4;4;5;2;5;6;4;3;4;3;5;4;5;6;5;6;6;5;6;5;6;6;5;4;3;6;2;3;5;2;3;7;5;5;3;3;4;5;4;5;4;3;5; GO:0030427;GO:0030426;GO:0030425;GO:0097060;GO:0042995;GO:0097458;GO:0016021;GO:0016020;GO:1902495;GO:0098589;GO:0044297;GO:0036477;GO:0043234;GO:0043235;GO:0030054;GO:0044425;GO:0044421;GO:0098590;GO:0043232;GO:0043229;GO:0034702;GO:0005622;GO:0043025;GO:0070160;GO:1990351;GO:0060076;GO:0043226;GO:0044424;GO:0031226;GO:0031224;GO:0005737;GO:0044456;GO:0043005;GO:0044459;GO:0008328;GO:0016323;GO:0045211;GO:0014069;GO:0005911;GO:0044463;GO:0044464;GO:0005623;GO:0043228;GO:0045202;GO:0005923;GO:0032281;GO:0099572;GO:0071944;GO:0098797;GO:0005615;GO:0098796;GO:0098805;GO:0098802;GO:0098794;GO:0005887;GO:0005886;GO:0032991;GO:0043198;GO:0005575;GO:0005576;GO:0043296; site of polarized growth;growth cone;dendrite;synaptic membrane;cell projection;neuron part;integral component of membrane;membrane;transmembrane transporter complex;membrane region;cell body;somatodendritic compartment;protein complex;receptor complex;cell junction;membrane part;extracellular region part;plasma membrane region;intracellular non-membrane-bounded organelle;intracellular organelle;ion channel complex;intracellular;neuronal cell body;occluding junction;transporter complex;excitatory synapse;organelle;intracellular part;intrinsic component of plasma membrane;intrinsic component of membrane;cytoplasm;synapse part;neuron projection;plasma membrane part;ionotropic glutamate receptor complex;basolateral plasma membrane;postsynaptic membrane;postsynaptic density;cell-cell junction;cell projection part;cell part;cell;non-membrane-bounded organelle;synapse;bicellular tight junction;AMPA glutamate receptor complex;postsynaptic specialization;cell periphery;plasma membrane protein complex;extracellular space;membrane protein complex;whole membrane;plasma membrane receptor complex;postsynapse;integral component of plasma membrane;plasma membrane;macromolecular complex;dendritic shaft;cellular_component;extracellular region;apical junction complex; 3;4;5;3;3;3;4;2;4;3;3;4;3;4;2;2;2;4;4;3;5;3;4;4;4;3;2;3;4;3;4;2;4;3;5;4;4;4;3;3;2;2;3;2;5;6;3;3;4;3;3;3;4;3;4;3;2;4;1;2;4; GO:0016740;GO:0019900;GO:0019902;GO:0005488;GO:0016301;GO:0035255;GO:0003824;GO:0016772;GO:0016776;GO:0035254;GO:0019899;GO:0005515;GO:0005102;GO:0003674;GO:0019201;GO:0019205;GO:0004385; transferase activity;kinase binding;phosphatase binding;binding;kinase activity;ionotropic glutamate receptor binding;catalytic activity;transferase activity, transferring phosphorus-containing groups;phosphotransferase activity, phosphate group as acceptor;glutamate receptor binding;enzyme binding;protein binding;receptor binding;molecular_function;nucleotide kinase activity;nucleobase-containing compound kinase activity;guanylate kinase activity; 3;5;5;2;5;6;2;4;5;5;4;3;4;1;7;6;6; K21098 IPR001478;IPR019583;IPR016313;IPR019590;IPR001452;IPR008145;IPR008144;IPR020590;IPR027417; PDZ domain;PDZ-associated domain of NMDA receptors;Disks large 1-like;Disks large homologue 1, N-terminal PEST domain;SH3 domain;Guanylate kinase/L-type calcium channel beta subunit;Guanylate kinase-like domain;Guanylate kinase, conserved site;P-loop containing nucleoside triphosphate hydrolase; cytosol, nucleus Hs10863921 1688.0 F [F] Nucleotide transport and metabolism; Q92797 Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2 - [SYMPK_HUMAN] 0.957 0.816 1.535 0.782 1.075 0.546 1.172794118 nan 0.72744186 nan 1.881127451 nan 0.507906977 nan GO:0019220;GO:0080090;GO:0019222;GO:0006470;GO:1901360;GO:0010604;GO:0048518;GO:0060255;GO:0046483;GO:0019538;GO:0006378;GO:0009893;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0035303;GO:0035304;GO:0035307;GO:0035306;GO:0016070;GO:0016071;GO:0031401;GO:0010562;GO:0016311;GO:0034641;GO:0006139;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0022610;GO:0009987;GO:0006725;GO:0032268;GO:0043170;GO:0006807;GO:0031325;GO:0031323;GO:0090304;GO:0043631;GO:0071704;GO:0010467;GO:0045937;GO:0031124;GO:0031123;GO:0051174;GO:0007155;GO:0044238;GO:0044237;GO:0006796;GO:0006793;GO:0048522;GO:0006396;GO:0006397; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;heterocycle metabolic process;protein metabolic process;mRNA polyadenylation;positive regulation of metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;regulation of cellular process;macromolecule modification;protein modification process;biological_process;cellular protein modification process;metabolic process;regulation of dephosphorylation;regulation of protein dephosphorylation;positive regulation of protein dephosphorylation;positive regulation of dephosphorylation;RNA metabolic process;mRNA metabolic process;positive regulation of protein modification process;positive regulation of phosphorus metabolic process;dephosphorylation;cellular nitrogen compound metabolic process;nucleobase-containing compound metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;biological adhesion;cellular process;cellular aromatic compound metabolic process;regulation of cellular protein metabolic process;macromolecule metabolic process;nitrogen compound metabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;RNA polyadenylation;organic substance metabolic process;gene expression;positive regulation of phosphate metabolic process;mRNA 3'-end processing;RNA 3'-end processing;regulation of phosphorus metabolic process;cell adhesion;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;positive regulation of cellular process;RNA processing;mRNA processing; 6;4;3;7;4;4;2;4;4;4;7;3;2;5;4;2;3;5;5;1;6;2;7;7;7;7;5;6;6;5;6;4;4;5;5;5;6;2;2;4;5;4;3;4;4;5;6;3;5;6;8;7;5;3;3;3;5;4;3;6;7; GO:0031974;GO:0031981;GO:0016020;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0005856;GO:0005654;GO:0030054;GO:0070160;GO:0044446;GO:0005737;GO:0005634;GO:0005911;GO:0044464;GO:0005623;GO:0005923;GO:0071944;GO:0043226;GO:0005886;GO:0005575;GO:0070013;GO:0043296; membrane-enclosed lumen;nuclear lumen;membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;cytoskeleton;nucleoplasm;cell junction;occluding junction;intracellular organelle part;cytoplasm;nucleus;cell-cell junction;cell part;cell;bicellular tight junction;cell periphery;organelle;plasma membrane;cellular_component;intracellular organelle lumen;apical junction complex; 2;5;2;4;4;3;4;3;2;3;3;3;3;5;5;2;4;3;4;5;3;2;2;5;3;2;3;1;4;4; K06100 map03015;map04530; mRNA surveillance pathway;Tight junction; IPR011989;IPR016024;IPR021850;IPR022075;IPR032460; Armadillo-like helical;Armadillo-type fold;Symplekin/Pta1;Symplekin C-terminal;Symplekin/Pta1, N-terminal; nucleus Hs4759196 2334.0 A [A] RNA processing and modification; Q96DT5 Dynein heavy chain 11, axonemal OS=Homo sapiens OX=9606 GN=DNAH11 PE=1 SV=4 - [DYH11_HUMAN] 1.02 1.203 0.93 0.929 1.159 0.854 0.847880299 nan 0.801553063 nan 0.773067332 nan 0.736842105 nan GO:0072359;GO:0072358;GO:0003341;GO:0007368;GO:0048513;GO:0003356;GO:0003352;GO:0044707;GO:0048870;GO:0006928;GO:0051674;GO:0065007;GO:0050794;GO:0008150;GO:0044767;GO:0009799;GO:0032886;GO:0044699;GO:0032502;GO:0032501;GO:0030317;GO:0009987;GO:0007017;GO:0032879;GO:0048731;GO:0060632;GO:0007275;GO:0007389;GO:0050789;GO:0044763;GO:0051179;GO:0040011;GO:0007507;GO:0051270;GO:0048856;GO:0007018;GO:0009855; circulatory system development;cardiovascular system development;cilium movement;determination of left/right symmetry;animal organ development;regulation of cilium beat frequency;regulation of cilium movement;single-multicellular organism process;cell motility;movement of cell or subcellular component;localization of cell;biological regulation;regulation of cellular process;biological_process;single-organism developmental process;specification of symmetry;regulation of microtubule-based process;single-organism process;developmental process;multicellular organismal process;sperm motility;cellular process;microtubule-based process;regulation of localization;system development;regulation of microtubule-based movement;multicellular organism development;pattern specification process;regulation of biological process;single-organism cellular process;localization;locomotion;heart development;regulation of cellular component movement;anatomical structure development;microtubule-based movement;determination of bilateral symmetry; 5;5;6;7;4;7;6;3;3;4;3;2;3;1;3;5;4;2;2;2;4;2;4;3;4;5;4;4;2;3;2;2;4;4;3;5;6; GO:0099512;GO:0099513;GO:0031512;GO:1902494;GO:0042995;GO:0043234;GO:0043232;GO:0044424;GO:0044422;GO:0043229;GO:0005929;GO:0030286;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0005874;GO:0005875;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0072372;GO:0015630;GO:0032991;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;motile primary cilium;catalytic complex;cell projection;protein complex;intracellular non-membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;cilium;dynein complex;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;microtubule;microtubule associated complex;cytoplasm;cell part;cell;intracellular;non-membrane-bounded organelle;primary cilium;microtubule cytoskeleton;macromolecular complex;cellular_component; 2;3;5;4;3;3;4;3;2;3;3;5;2;5;4;3;4;4;4;2;2;3;3;4;6;2;1; GO:1901363;GO:0000166;GO:0016818;GO:0097367;GO:0016817;GO:0005524;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0016787;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0036094;GO:0043168; heterocyclic compound binding;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;ATP binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;hydrolase activity;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;anion binding; 3;4;5;3;4;6;1;2;8;4;5;5;8;9;3;2;3;6;6;5;6;4;5;3;6;5;4;7;3;4; K10408 map05016; Huntington's disease; IPR030443;IPR011704;IPR003593;IPR035699;IPR013594;IPR013602;IPR024743;IPR004273;IPR035706;IPR026983;IPR027417;IPR024317; Dynein heavy chain 11, axonemal;ATPase, dynein-related, AAA domain;AAA+ ATPase domain;Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;Dynein heavy chain, domain-1;Dynein heavy chain, domain-2;Dynein heavy chain, coiled coil stalk;Dynein heavy chain domain;Dynein heavy chain, ATP-binding dynein motor region D5;Dynein heavy chain;P-loop containing nucleoside triphosphate hydrolase;Dynein heavy chain, AAA module D4; cytosol Hs16507235 9361.0 Z [Z] Cytoskeleton; Q5HYK9 Zinc finger protein 667 OS=Homo sapiens OX=9606 GN=ZNF667 PE=2 SV=2 - [ZN667_HUMAN] 1.186 0.807 1.291 0.853 0.709 1.927 1.469640644 0.00688778 1.203102962 0.108514935 1.599752169 0.009338633 2.717912553 0.001296393 GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0006807;GO:0044237;GO:0034645;GO:0043170;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0009987;GO:0006139;GO:0019219;GO:0006725;GO:0006366;GO:0009889;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0034641;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;cellular process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;transcription from RNA polymerase II promoter;regulation of biosynthetic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular nitrogen compound metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;3;3;5;4;7;6;4;4;5;6;2;3;5;7;2;4;5;5;2;4;5;4;7;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;4;6;5;6;5; GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;4;2;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0003712;GO:0000989;GO:0000988;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;transcription cofactor activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;4;3;2;5;4;3;3;3;2; K09228 IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs11545815 793.0 R [R] General function prediction only; Q5T7N2 LINE-1 type transposase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=L1TD1 PE=1 SV=1 - [LITD1_HUMAN] 1.042 1.559 0.429 1.117 1.373 0.411 0.668377165 nan 0.813546977 nan 0.275176395 nan 0.299344501 nan IPR004244;IPR035300; Transposase, L1;L1 transposable element, dsRBD-like domain; nucleus P25054 Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2 - [APC_HUMAN] 1.062 1.151 0.961 0.921 1.061 0.904 0.922675934 0.56948692 0.86804901 0.627865682 0.834926151 0.510684553 0.85202639 0.429173596 GO:0044257;GO:0044281;GO:0051716;GO:0032434;GO:0051494;GO:0051493;GO:0033238;GO:0007088;GO:0048468;GO:0045859;GO:0031109;GO:0000819;GO:0042325;GO:0042326;GO:0019538;GO:0010639;GO:0051783;GO:0051782;GO:0051784;GO:0009896;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0090263;GO:0030177;GO:0031175;GO:0071901;GO:0071900;GO:0050789;GO:0051348;GO:0009308;GO:0007050;GO:0043412;GO:0007059;GO:0048869;GO:0097305;GO:2001251;GO:0051129;GO:0051128;GO:1903827;GO:0042176;GO:0042177;GO:1901991;GO:1901990;GO:0043244;GO:0043241;GO:0043242;GO:0051247;GO:0000280;GO:0000281;GO:0097194;GO:1901988;GO:0008285;GO:0008283;GO:0006974;GO:0051985;GO:0034329;GO:0051983;GO:0060341;GO:0030030;GO:0030031;GO:0008608;GO:0022402;GO:0051306;GO:0008219;GO:0051304;GO:0007275;GO:0051301;GO:0006521;GO:0006520;GO:0051302;GO:0043065;GO:0043067;GO:0043068;GO:0090090;GO:0006468;GO:0006469;GO:0000278;GO:1990089;GO:0006461;GO:0006464;GO:0044767;GO:0044763;GO:0040011;GO:0051272;GO:0051270;GO:0051276;GO:0040017;GO:0048856;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0033044;GO:0008104;GO:0007163;GO:0007165;GO:0007166;GO:0031344;GO:0031268;GO:0031269;GO:0044710;GO:0045786;GO:0070848;GO:1901799;GO:0044092;GO:0033036;GO:0010033;GO:0044248;GO:1904029;GO:0044784;GO:0045841;GO:0060491;GO:0006807;GO:0051179;GO:0044267;GO:0044265;GO:0044260;GO:0070271;GO:0007049;GO:0006915;GO:0050793;GO:0050790;GO:0050794;GO:0060070;GO:0050896;GO:0010498;GO:0051338;GO:0006511;GO:2000145;GO:2000147;GO:0031346;GO:0033045;GO:0033046;GO:0033047;GO:0033043;GO:0010564;GO:0033048;GO:0007043;GO:0070887;GO:0032886;GO:0044699;GO:0032880;GO:0051248;GO:0010563;GO:0051246;GO:0010565;GO:0009057;GO:0031399;GO:1901700;GO:0030178;GO:0040012;GO:0042493;GO:0061640;GO:0043933;GO:0034330;GO:0045216;GO:0045930;GO:0030182;GO:0045936;GO:0061136;GO:1902100;GO:0022411;GO:0042221;GO:0022008;GO:0043624;GO:0006996;GO:0044238;GO:0044237;GO:0043297;GO:0019220;GO:0019222;GO:0032435;GO:0048585;GO:0048584;GO:0048583;GO:0030111;GO:0010965;GO:0071840;GO:0009968;GO:0009966;GO:0009967;GO:0048513;GO:0048518;GO:0048519;GO:0042127;GO:1901880;GO:0031274;GO:0031272;GO:0043436;GO:1902099;GO:0044700;GO:1901564;GO:0044707;GO:0016055;GO:0033554;GO:0070507;GO:0060828;GO:0033673;GO:0022607;GO:0006921;GO:0070830;GO:0006928;GO:0051674;GO:2000816;GO:0009064;GO:0042981;GO:0031577;GO:0043549;GO:1904030;GO:0016477;GO:0012501;GO:0006950;GO:0048731;GO:0051603;GO:0031400;GO:1903051;GO:0030154;GO:0043632;GO:0043161;GO:0006508;GO:0032502;GO:0032501;GO:2000211;GO:0031330;GO:1903050;GO:0009987;GO:0019941;GO:0019752;GO:0032879;GO:0071363;GO:0098813;GO:0044772;GO:0001932;GO:0030071;GO:0007389;GO:0032984;GO:0007026;GO:0071704;GO:0071310;GO:0030335;GO:0030334;GO:0034613;GO:0051174;GO:0051171;GO:0009056;GO:0051641;GO:0000070;GO:0042180;GO:0000075;GO:0051726;GO:0000079;GO:1902589;GO:0007094;GO:0007091;GO:0007093;GO:0031110;GO:0031111;GO:0031114;GO:0080090;GO:0010605;GO:0010604;GO:0070727;GO:0045839;GO:0031016;GO:0060255;GO:0030162;GO:0030163;GO:0000910;GO:0043648;GO:0048870;GO:1901879;GO:0000226;GO:0007067;GO:1901575;GO:1903362;GO:1903363;GO:0016043;GO:0065003;GO:0065007;GO:0065009;GO:0051130;GO:0009719;GO:0071174;GO:0071173;GO:1901987;GO:0036211;GO:0008150;GO:0008152;GO:0045165;GO:0045732;GO:0045736;GO:0001708;GO:0016310;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0023051;GO:0010647;GO:0010646;GO:0043086;GO:0022610;GO:1901605;GO:0044106;GO:0045595;GO:0007010;GO:0032269;GO:0032268;GO:0006082;GO:0043170;GO:0006536;GO:0045861;GO:0071495;GO:1990090;GO:0031329;GO:0031324;GO:0031323;GO:1903047;GO:0044770;GO:0010948;GO:0010942;GO:0010941;GO:0000820;GO:0071822;GO:0051261;GO:0048666;GO:0007346;GO:0007155;GO:0007154;GO:0048699;GO:0007017;GO:0007399;GO:0007019;GO:0044087;GO:0044085;GO:0048285;GO:0001933;GO:0044089;GO:0051988; cellular protein catabolic process;small molecule metabolic process;cellular response to stimulus;regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;regulation of cellular amine metabolic process;regulation of mitotic nuclear division;cell development;regulation of protein kinase activity;microtubule polymerization or depolymerization;sister chromatid segregation;regulation of phosphorylation;negative regulation of phosphorylation;protein metabolic process;negative regulation of organelle organization;regulation of nuclear division;negative regulation of cell division;negative regulation of nuclear division;positive regulation of catabolic process;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of canonical Wnt signaling pathway;positive regulation of Wnt signaling pathway;neuron projection development;negative regulation of protein serine/threonine kinase activity;regulation of protein serine/threonine kinase activity;regulation of biological process;negative regulation of transferase activity;amine metabolic process;cell cycle arrest;macromolecule modification;chromosome segregation;cellular developmental process;response to alcohol;negative regulation of chromosome organization;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;regulation of protein catabolic process;negative regulation of protein catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;regulation of protein complex disassembly;protein complex disassembly;negative regulation of protein complex disassembly;positive regulation of protein metabolic process;nuclear division;mitotic cytokinesis;execution phase of apoptosis;negative regulation of cell cycle phase transition;negative regulation of cell proliferation;cell proliferation;cellular response to DNA damage stimulus;negative regulation of chromosome segregation;cell junction assembly;regulation of chromosome segregation;regulation of cellular localization;cell projection organization;cell projection assembly;attachment of spindle microtubules to kinetochore;cell cycle process;mitotic sister chromatid separation;cell death;chromosome separation;multicellular organism development;cell division;regulation of cellular amino acid metabolic process;cellular amino acid metabolic process;regulation of cell division;positive regulation of apoptotic process;regulation of programmed cell death;positive regulation of programmed cell death;negative regulation of canonical Wnt signaling pathway;protein phosphorylation;negative regulation of protein kinase activity;mitotic cell cycle;response to nerve growth factor;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism cellular process;locomotion;positive regulation of cellular component movement;regulation of cellular component movement;chromosome organization;positive regulation of locomotion;anatomical structure development;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;regulation of chromosome organization;protein localization;establishment or maintenance of cell polarity;signal transduction;cell surface receptor signaling pathway;regulation of cell projection organization;pseudopodium organization;pseudopodium assembly;single-organism metabolic process;negative regulation of cell cycle;response to growth factor;negative regulation of proteasomal protein catabolic process;negative regulation of molecular function;macromolecule localization;response to organic substance;cellular catabolic process;regulation of cyclin-dependent protein kinase activity;metaphase/anaphase transition of cell cycle;negative regulation of mitotic metaphase/anaphase transition;regulation of cell projection assembly;nitrogen compound metabolic process;localization;cellular protein metabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;protein complex biogenesis;cell cycle;apoptotic process;regulation of developmental process;regulation of catalytic activity;regulation of cellular process;canonical Wnt signaling pathway;response to stimulus;proteasomal protein catabolic process;regulation of transferase activity;ubiquitin-dependent protein catabolic process;regulation of cell motility;positive regulation of cell motility;positive regulation of cell projection organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;regulation of organelle organization;regulation of cell cycle process;negative regulation of mitotic sister chromatid segregation;cell-cell junction assembly;cellular response to chemical stimulus;regulation of microtubule-based process;single-organism process;regulation of protein localization;negative regulation of protein metabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;regulation of cellular ketone metabolic process;macromolecule catabolic process;regulation of protein modification process;response to oxygen-containing compound;negative regulation of Wnt signaling pathway;regulation of locomotion;response to drug;cytoskeleton-dependent cytokinesis;macromolecular complex subunit organization;cell junction organization;cell-cell junction organization;negative regulation of mitotic cell cycle;neuron differentiation;negative regulation of phosphate metabolic process;regulation of proteasomal protein catabolic process;negative regulation of metaphase/anaphase transition of cell cycle;cellular component disassembly;response to chemical;neurogenesis;cellular protein complex disassembly;organelle organization;primary metabolic process;cellular metabolic process;apical junction assembly;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;regulation of mitotic sister chromatid separation;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;animal organ development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;negative regulation of protein depolymerization;positive regulation of pseudopodium assembly;regulation of pseudopodium assembly;oxoacid metabolic process;regulation of metaphase/anaphase transition of cell cycle;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;Wnt signaling pathway;cellular response to stress;regulation of microtubule cytoskeleton organization;regulation of canonical Wnt signaling pathway;negative regulation of kinase activity;cellular component assembly;cellular component disassembly involved in execution phase of apoptosis;bicellular tight junction assembly;movement of cell or subcellular component;localization of cell;negative regulation of mitotic sister chromatid separation;glutamine family amino acid metabolic process;regulation of apoptotic process;spindle checkpoint;regulation of kinase activity;negative regulation of cyclin-dependent protein kinase activity;cell migration;programmed cell death;response to stress;system development;proteolysis involved in cellular protein catabolic process;negative regulation of protein modification process;negative regulation of proteolysis involved in cellular protein catabolic process;cell differentiation;modification-dependent macromolecule catabolic process;proteasome-mediated ubiquitin-dependent protein catabolic process;proteolysis;developmental process;multicellular organismal process;regulation of glutamate metabolic process;negative regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;carboxylic acid metabolic process;regulation of localization;cellular response to growth factor stimulus;nuclear chromosome segregation;mitotic cell cycle phase transition;regulation of protein phosphorylation;regulation of mitotic metaphase/anaphase transition;pattern specification process;macromolecular complex disassembly;negative regulation of microtubule depolymerization;organic substance metabolic process;cellular response to organic substance;positive regulation of cell migration;regulation of cell migration;cellular protein localization;regulation of phosphorus metabolic process;regulation of nitrogen compound metabolic process;catabolic process;cellular localization;mitotic sister chromatid segregation;cellular ketone metabolic process;cell cycle checkpoint;regulation of cell cycle;regulation of cyclin-dependent protein serine/threonine kinase activity;single-organism organelle organization;mitotic spindle assembly checkpoint;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle checkpoint;regulation of microtubule polymerization or depolymerization;negative regulation of microtubule polymerization or depolymerization;regulation of microtubule depolymerization;regulation of primary metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;negative regulation of mitotic nuclear division;pancreas development;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;cytokinesis;dicarboxylic acid metabolic process;cell motility;regulation of protein depolymerization;microtubule cytoskeleton organization;mitotic nuclear division;organic substance catabolic process;regulation of cellular protein catabolic process;negative regulation of cellular protein catabolic process;cellular component organization;macromolecular complex assembly;biological regulation;regulation of molecular function;positive regulation of cellular component organization;response to endogenous stimulus;mitotic spindle checkpoint;spindle assembly checkpoint;regulation of cell cycle phase transition;protein modification process;biological_process;metabolic process;cell fate commitment;positive regulation of protein catabolic process;negative regulation of cyclin-dependent protein serine/threonine kinase activity;cell fate specification;phosphorylation;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;biological adhesion;alpha-amino acid metabolic process;cellular amine metabolic process;regulation of cell differentiation;cytoskeleton organization;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;organic acid metabolic process;macromolecule metabolic process;glutamate metabolic process;negative regulation of proteolysis;cellular response to endogenous stimulus;cellular response to nerve growth factor stimulus;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;negative regulation of cell cycle process;positive regulation of cell death;regulation of cell death;regulation of glutamine family amino acid metabolic process;protein complex subunit organization;protein depolymerization;neuron development;regulation of mitotic cell cycle;cell adhesion;cell communication;generation of neurons;microtubule-based process;nervous system development;microtubule depolymerization;regulation of cellular component biogenesis;cellular component biogenesis;organelle fission;negative regulation of protein phosphorylation;positive regulation of cellular component biogenesis;regulation of attachment of spindle microtubules to kinetochore; 6;4;3;8;6;6;5;6;4;7;6;5;7;7;4;5;5;4;5;4;4;4;3;3;6;5;5;9;8;2;6;5;5;5;4;4;5;6;4;4;5;5;5;6;6;5;6;5;5;6;6;4;6;4;3;5;4;5;4;4;4;5;5;4;6;4;5;4;4;5;4;4;6;5;5;6;7;8;5;4;5;6;3;3;2;4;4;5;3;3;5;4;3;3;6;4;4;4;5;5;5;6;3;4;5;7;4;3;4;4;5;6;7;4;3;2;5;5;4;4;4;6;3;4;3;7;2;6;5;8;4;4;5;5;5;6;5;5;6;6;4;4;2;4;5;5;5;5;5;6;4;5;3;4;6;4;4;5;5;6;6;7;7;4;3;6;7;4;3;3;7;6;3;8;3;3;3;5;7;2;4;4;4;4;2;2;4;6;4;5;5;6;3;4;3;6;4;5;6;7;4;5;7;4;3;7;6;6;6;6;6;4;5;3;4;6;6;7;5;6;7;5;2;2;7;5;7;2;7;6;3;6;5;6;7;7;4;5;7;3;5;5;5;5;5;4;3;3;6;4;5;4;6;4;6;6;6;6;7;7;4;4;4;4;6;4;4;6;5;5;7;3;6;5;5;4;6;6;3;5;2;3;4;3;6;7;6;5;1;2;5;5;5;5;6;3;3;4;2;4;3;4;4;5;2;5;5;4;5;5;5;4;4;7;6;4;5;5;4;4;5;5;5;4;4;6;5;8;5;5;3;4;7;4;5;7;3;3;5;7;3;5; GO:0099512;GO:0099513;GO:0044428;GO:0044424;GO:0044425;GO:0044427;GO:0044422;GO:0005654;GO:0030054;GO:0043025;GO:0031256;GO:0070160;GO:0070161;GO:0031253;GO:0031252;GO:0016328;GO:0005912;GO:0005911;GO:0044463;GO:0044464;GO:0071944;GO:0001726;GO:0070013;GO:0016020;GO:0098589;GO:0044297;GO:0044295;GO:0042995;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0005923;GO:0044430;GO:0019897;GO:0019898;GO:0031090;GO:0032587;GO:0044459;GO:0043228;GO:0045202;GO:0044306;GO:0043227;GO:0005815;GO:0030027;GO:0043296;GO:0031974;GO:0031975;GO:0036477;GO:0098590;GO:0043229;GO:0005622;GO:0043226;GO:0005856;GO:0030877;GO:0012505;GO:0044446;GO:0044444;GO:0005938;GO:0005737;GO:0005634;GO:0005635;GO:0043005;GO:1990909;GO:0016342;GO:0000775;GO:0000776;GO:0005813;GO:0030427;GO:0030426;GO:0030425;GO:0030424;GO:0031981;GO:0032991;GO:0031965;GO:0031967;GO:0099568;GO:0005874;GO:0098687;GO:0033267;GO:0005623;GO:0005575;GO:0098796;GO:0098805;GO:0097458;GO:0005694;GO:0015630;GO:0005886;GO:0070852;GO:0098797; supramolecular fiber;polymeric cytoskeletal fiber;nuclear part;intracellular part;membrane part;chromosomal part;organelle part;nucleoplasm;cell junction;neuronal cell body;leading edge membrane;occluding junction;anchoring junction;cell projection membrane;cell leading edge;lateral plasma membrane;adherens junction;cell-cell junction;cell projection part;cell part;cell periphery;ruffle;intracellular organelle lumen;membrane;membrane region;cell body;axonal growth cone;cell projection;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;bicellular tight junction;cytoskeletal part;extrinsic component of plasma membrane;extrinsic component of membrane;organelle membrane;ruffle membrane;plasma membrane part;non-membrane-bounded organelle;synapse;neuron projection terminus;membrane-bounded organelle;microtubule organizing center;lamellipodium;apical junction complex;membrane-enclosed lumen;envelope;somatodendritic compartment;plasma membrane region;intracellular organelle;intracellular;organelle;cytoskeleton;beta-catenin destruction complex;endomembrane system;intracellular organelle part;cytoplasmic part;cell cortex;cytoplasm;nucleus;nuclear envelope;neuron projection;Wnt signalosome;catenin complex;chromosome, centromeric region;kinetochore;centrosome;site of polarized growth;growth cone;dendrite;axon;nuclear lumen;macromolecular complex;nuclear membrane;organelle envelope;cytoplasmic region;microtubule;chromosomal region;axon part;cell;cellular_component;membrane protein complex;whole membrane;neuron part;chromosome;microtubule cytoskeleton;plasma membrane;cell body fiber;plasma membrane protein complex; 2;3;4;3;2;4;2;5;2;4;4;4;3;4;3;4;4;3;3;2;3;4;4;2;3;3;5;3;3;4;4;3;5;5;4;4;3;3;5;3;3;2;4;3;5;4;4;2;3;4;4;3;3;2;5;4;3;3;4;4;4;5;4;4;4;5;6;4;5;3;4;5;5;5;2;4;4;5;4;5;4;2;1;3;3;3;5;6;3;5;4; GO:0098772;GO:0005488;GO:0019887;GO:0051010;GO:0019900;GO:0019899;GO:0032403;GO:0005515;GO:0003674;GO:0019901;GO:0044877;GO:0008092;GO:0030234;GO:0008017;GO:0008013;GO:0045295;GO:0019207;GO:0015631; molecular function regulator;binding;protein kinase regulator activity;microtubule plus-end binding;kinase binding;enzyme binding;protein complex binding;protein binding;molecular_function;protein kinase binding;macromolecular complex binding;cytoskeletal protein binding;enzyme regulator activity;microtubule binding;beta-catenin binding;gamma-catenin binding;kinase regulator activity;tubulin binding; 2;2;5;6;5;4;4;3;1;6;3;4;3;5;4;4;4;5; K02085 map04310;map04390;map04550;map04810;map05166;map05200;map05206;map05210;map05213;map05217; Wnt signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Regulation of actin cytoskeleton;HTLV-I infection;Pathways in cancer;MicroRNAs in cancer;Colorectal cancer;Endometrial cancer;Basal cell carcinoma; IPR016024;IPR009224;IPR009234;IPR009232;IPR009223;IPR000225;IPR026831;IPR026836;IPR009240;IPR032038;IPR011989;IPR026818; Armadillo-type fold;SAMP;Adenomatous polyposis coli protein basic domain;EB-1 binding;Adenomatous polyposis coli protein repeat;Armadillo;Adenomatous polyposis coli protein;Adenomatous polyposis coli;Adenomatous polyposis coli protein, 15 residue repeat;Adenomatous polyposis coli, N-terminal dimerisation domain;Armadillo-like helical;Adenomatous polyposis coli (APC) family; nucleus Hs4557319 5848.0 TZ [T] Signal transduction mechanisms;[Z] Cytoskeleton; Q9Y4A9 Olfactory receptor 10H1 OS=Homo sapiens OX=9606 GN=OR10H1 PE=2 SV=1 - [O10H1_HUMAN] 1.024 0.863 1.135 0.92 1.025 1.61 1.186558517 nan 0.897560976 nan 1.315179606 nan 1.570731707 nan GO:0016021;GO:0016020;GO:0044464;GO:0005623;GO:0005575;GO:0071944;GO:0044425;GO:0005886;GO:0031224; integral component of membrane;membrane;cell part;cell;cellular_component;cell periphery;membrane part;plasma membrane;intrinsic component of membrane; 4;2;2;2;1;3;2;3;3; GO:0004930;GO:0038023;GO:0060089;GO:0004888;GO:0003674;GO:0004872;GO:0004871;GO:0004984;GO:0099600; G-protein coupled receptor activity;signaling receptor activity;molecular transducer activity;transmembrane signaling receptor activity;molecular_function;receptor activity;signal transducer activity;olfactory receptor activity;transmembrane receptor activity; 5;3;2;4;1;3;2;5;4; K04257 map04740; Olfactory transduction; IPR000276;IPR017452;IPR000725; G protein-coupled receptor, rhodopsin-like;GPCR, rhodopsin-like, 7TM;Olfactory receptor; plasma membrane O60909 Beta-1,4-galactosyltransferase 2 OS=Homo sapiens OX=9606 GN=B4GALT2 PE=1 SV=1 - [B4GT2_HUMAN] 1.035 1.101 1.095 0.666 1.498 nan 0.940054496 nan 0.44459279 nan 0.994550409 nan nan nan GO:0044281;GO:0044710;GO:0044711;GO:0018193;GO:0042339;GO:0043436;GO:1901564;GO:1901566;GO:0019538;GO:0030203;GO:0018146;GO:0006807;GO:0043170;GO:0044267;GO:0044260;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0044272;GO:0043413;GO:0006022;GO:0006023;GO:0006024;GO:0018196;GO:0044249;GO:0034645;GO:0044699;GO:0043687;GO:0009987;GO:0006082;GO:1901137;GO:1901135;GO:1903510;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0071704;GO:0018279;GO:1901576;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0044238;GO:0005975;GO:0044237;GO:0006790; small molecule metabolic process;single-organism metabolic process;single-organism biosynthetic process;peptidyl-amino acid modification;keratan sulfate metabolic process;oxoacid metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;glycosaminoglycan metabolic process;keratan sulfate biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;sulfur compound biosynthetic process;macromolecule glycosylation;aminoglycan metabolic process;aminoglycan biosynthetic process;glycosaminoglycan biosynthetic process;peptidyl-asparagine modification;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;post-translational protein modification;cellular process;organic acid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;mucopolysaccharide metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;organic substance metabolic process;protein N-linked glycosylation via asparagine;organic substance biosynthetic process;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;primary metabolic process;carbohydrate metabolic process;cellular metabolic process;sulfur compound metabolic process; 4;3;4;7;5;5;4;5;4;6;6;3;4;5;4;5;5;1;2;4;5;6;5;5;6;8;4;5;2;7;2;4;5;4;7;5;6;4;5;3;6;4;5;6;3;5;3;3;4;3;4; GO:0016021;GO:0016020;GO:0005795;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044431;GO:0031224;GO:0031985;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0032580;GO:0044464;GO:0005623;GO:0005622;GO:0031984;GO:0005575;GO:0098791; integral component of membrane;membrane;Golgi stack;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;Golgi apparatus part;intrinsic component of membrane;Golgi cisterna;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;Golgi cisterna membrane;cell part;cell;intracellular;organelle subcompartment;cellular_component;Golgi subcompartment; 4;2;5;4;4;4;3;2;2;3;3;2;4;3;6;3;5;3;4;4;3;6;2;2;3;4;1;5; GO:0008378;GO:0016740;GO:0046872;GO:0016757;GO:0003674;GO:0005488;GO:0003831;GO:0035250;GO:0003824;GO:0016758;GO:0003945;GO:0043169;GO:0043167;GO:0004461;GO:0008194; galactosyltransferase activity;transferase activity;metal ion binding;transferase activity, transferring glycosyl groups;molecular_function;binding;beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;UDP-galactosyltransferase activity;catalytic activity;transferase activity, transferring hexosyl groups;N-acetyllactosamine synthase activity;cation binding;ion binding;lactose synthase activity;UDP-glycosyltransferase activity; 6;3;5;4;1;2;7;6;2;5;7;4;3;7;5; K07967 map00052;map00510;map00513;map00514;map00533;map00601;map01100; Galactose metabolism;N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Other types of O-glycan biosynthesis;Glycosaminoglycan biosynthesis - keratan sulfate;Glycosphingolipid biosynthesis - lacto and neolacto series;Metabolic pathways; IPR027791;IPR003859;IPR027995;IPR029044; Galactosyltransferase, C-terminal;Beta-1,4-galactosyltransferase;Galactosyltransferase, N-terminal;Nucleotide-diphospho-sugar transferases; endoplasmic reticulum Hs4502347 768.0 G [G] Carbohydrate transport and metabolism; Q15293 Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1 - [RCN1_HUMAN] 1.172 0.992 0.822 1.289 0.907 1.544 1.181451613 0.020665271 1.421168688 0.004685982 0.828629032 0.027576467 1.702315325 0.005654582 GO:0009790;GO:0009792;GO:0007275;GO:0044699;GO:0001701;GO:0048513;GO:0043009;GO:0032502;GO:0032501;GO:0044767;GO:0008150;GO:0044707;GO:0007423;GO:0001654;GO:0048856;GO:0048731;GO:0043010; embryo development;embryo development ending in birth or egg hatching;multicellular organism development;single-organism process;in utero embryonic development;animal organ development;chordate embryonic development;developmental process;multicellular organismal process;single-organism developmental process;biological_process;single-multicellular organism process;sensory organ development;eye development;anatomical structure development;system development;camera-type eye development; 5;6;4;2;8;4;7;2;2;3;1;3;4;5;3;4;6; GO:0005783;GO:0005788;GO:0031974;GO:0043229;GO:0043227;GO:0005737;GO:0044446;GO:0043226;GO:0044432;GO:0012505;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044424;GO:0044422; endoplasmic reticulum;endoplasmic reticulum lumen;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;cytoplasm;intracellular organelle part;organelle;endoplasmic reticulum part;endomembrane system;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;intracellular part;organelle part; 4;5;2;3;3;4;3;2;4;3;4;3;2;2;3;1;4;4;3;2; GO:0003674;GO:0005488;GO:0043167;GO:0005509;GO:0046872;GO:0043169; molecular_function;binding;ion binding;calcium ion binding;metal ion binding;cation binding; 1;2;3;6;5;4; IPR011992;IPR018247;IPR002048;IPR027241; EF-hand domain pair;EF-Hand 1, calcium-binding site;EF-hand domain;Reticulocalbin-1; extracellular Hs4506455 677.0 TU [T] Signal transduction mechanisms;[U] Intracellular trafficking, secretion, and vesicular transport; Q5CZC0 Fibrous sheath-interacting protein 2 OS=Homo sapiens OX=9606 GN=FSIP2 PE=2 SV=4 - [FSIP2_HUMAN] 1.137 0.615 1.371 0.901 0.721 1.761 1.848780488 0.040408586 1.249653259 0.08482216 2.229268293 0.012413494 2.442441054 0.002302088 GO:0005737;GO:0043231;GO:0044464;GO:0043229;GO:0005739;GO:0005622;GO:0005575;GO:0044444;GO:0005623;GO:0044424;GO:0043227;GO:0043226; cytoplasm;intracellular membrane-bounded organelle;cell part;intracellular organelle;mitochondrion;intracellular;cellular_component;cytoplasmic part;cell;intracellular part;membrane-bounded organelle;organelle; 4;4;2;3;5;3;1;4;2;3;3;2; IPR031554; Fibrous sheath-interacting protein 2, C-terminal; cytosol Q9BZL1 Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1 - [UBL5_HUMAN] 0.612 0.9 1.705 0.765 1.008 1.129 0.68 nan 0.758928571 nan 1.894444444 nan 1.120039683 nan GO:0090304;GO:0034641;GO:0006807;GO:0044237;GO:0043170;GO:1901360;GO:0006139;GO:0044260;GO:0071704;GO:0010467;GO:0044267;GO:0008380;GO:0044238;GO:0009987;GO:0006725;GO:0000398;GO:0006464;GO:0000375;GO:0043412;GO:0000377;GO:0008150;GO:0008152;GO:0046483;GO:0016070;GO:0016071;GO:0019538;GO:0036211;GO:0006396;GO:0006397; nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;macromolecule metabolic process;organic cyclic compound metabolic process;nucleobase-containing compound metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;gene expression;cellular protein metabolic process;RNA splicing;primary metabolic process;cellular process;cellular aromatic compound metabolic process;mRNA splicing, via spliceosome;cellular protein modification process;RNA splicing, via transesterification reactions;macromolecule modification;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;biological_process;metabolic process;heterocycle metabolic process;RNA metabolic process;mRNA metabolic process;protein metabolic process;protein modification process;RNA processing;mRNA processing; 5;4;3;3;4;4;4;4;3;5;5;7;3;2;4;8;6;8;5;9;1;2;4;5;6;4;5;6;7; GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 3;2;4;5;4;2;3;2;3;1;3; GO:0003674;GO:0031386; molecular_function;protein tag; 1;2; K13113 map04212; Longevity regulating pathway - worm; IPR000626;IPR029071; Ubiquitin domain;Ubiquitin-related domain; extracellular Hs13236510 150.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9H497 Torsin-3A OS=Homo sapiens OX=9606 GN=TOR3A PE=1 SV=1 - [TOR3A_HUMAN] 1.225 1.489 0.387 1.033 1.279 0.642 0.822699799 0.035159058 0.807662236 0.015545244 0.259905977 3.53E-07 0.501954652 0.67597862 GO:0005783;GO:0005788;GO:0031974;GO:0043226;GO:0043229;GO:0044424;GO:0043227;GO:0044446;GO:0070062;GO:0070013;GO:0044421;GO:0044432;GO:0005622;GO:0012505;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005737;GO:0005575;GO:0044444;GO:0005576;GO:0044422; endoplasmic reticulum;endoplasmic reticulum lumen;membrane-enclosed lumen;organelle;intracellular organelle;intracellular part;membrane-bounded organelle;intracellular organelle part;extracellular exosome;intracellular organelle lumen;extracellular region part;endoplasmic reticulum part;intracellular;endomembrane system;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;cytoplasm;cellular_component;cytoplasmic part;extracellular region;organelle part; 4;5;2;2;3;3;3;3;4;4;2;4;3;3;3;4;3;4;3;2;2;4;1;4;2;2; GO:0035639;GO:0003674;GO:0005488;GO:0016887;GO:0000166;GO:1901363;GO:0001883;GO:0001882;GO:0043168;GO:0043167;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0017111;GO:0036094;GO:0003824;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;ATPase activity;nucleotide binding;heterocyclic compound binding;purine nucleoside binding;nucleoside binding;anion binding;ion binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;8;4;3;5;4;4;3;4;5;5;6;3;7;3;2;5;6;3;3;4;6;6;5;6;4; K23000 IPR010448;IPR030552;IPR027417; Torsin;Torsin-3A;P-loop containing nucleoside triphosphate hydrolase; extracellular Hs11641299 817.0 R [R] General function prediction only; Q9BYV7 Beta,beta-carotene 9',10'-oxygenase OS=Homo sapiens OX=9606 GN=BCO2 PE=1 SV=5 - [BCDO2_HUMAN] 0.889 1.179 1.083 0.794 1.399 0.329 0.754028838 nan 0.567548249 nan 0.918575064 nan 0.235167977 nan GO:0006775;GO:0019222;GO:0044281;GO:0044712;GO:0042445;GO:0044710;GO:0016108;GO:0016101;GO:0006766;GO:0007603;GO:0007602;GO:0043436;GO:0055114;GO:0044700;GO:0009605;GO:0016119;GO:0009416;GO:0007165;GO:0042391;GO:0051716;GO:0046247;GO:1901575;GO:0016042;GO:0065007;GO:0065008;GO:0006629;GO:2000377;GO:0050794;GO:0008150;GO:0008300;GO:0008152;GO:0016116;GO:0044238;GO:0051606;GO:0050896;GO:0009314;GO:0044248;GO:0023052;GO:0044242;GO:0042573;GO:0042574;GO:0044699;GO:0016122;GO:0016121;GO:0006721;GO:0006720;GO:0009987;GO:0072593;GO:0044255;GO:0006081;GO:0006082;GO:0031323;GO:0019752;GO:0001523;GO:0042214;GO:0050789;GO:0071704;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0010817;GO:0044763;GO:0007154;GO:0032787;GO:0009056;GO:0034754;GO:0009628;GO:0051881;GO:0044237; fat-soluble vitamin metabolic process;regulation of metabolic process;small molecule metabolic process;single-organism catabolic process;hormone metabolic process;single-organism metabolic process;tetraterpenoid metabolic process;diterpenoid metabolic process;vitamin metabolic process;phototransduction, visible light;phototransduction;oxoacid metabolic process;oxidation-reduction process;single organism signaling;response to external stimulus;carotene metabolic process;response to light stimulus;signal transduction;regulation of membrane potential;cellular response to stimulus;terpene catabolic process;organic substance catabolic process;lipid catabolic process;biological regulation;regulation of biological quality;lipid metabolic process;regulation of reactive oxygen species metabolic process;regulation of cellular process;biological_process;isoprenoid catabolic process;metabolic process;carotenoid metabolic process;primary metabolic process;detection of stimulus;response to stimulus;response to radiation;cellular catabolic process;signaling;cellular lipid catabolic process;retinoic acid metabolic process;retinal metabolic process;single-organism process;xanthophyll metabolic process;carotene catabolic process;terpenoid metabolic process;isoprenoid metabolic process;cellular process;reactive oxygen species metabolic process;cellular lipid metabolic process;cellular aldehyde metabolic process;organic acid metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;retinoid metabolic process;terpene metabolic process;regulation of biological process;organic substance metabolic process;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;regulation of hormone levels;single-organism cellular process;cell communication;monocarboxylic acid metabolic process;catabolic process;cellular hormone metabolic process;response to abiotic stimulus;regulation of mitochondrial membrane potential;cellular metabolic process; 6;3;4;4;3;3;7;7;5;6;5;5;4;3;3;7;5;4;4;3;7;4;5;2;3;4;5;3;1;6;2;8;3;3;2;4;4;2;5;5;5;2;9;8;6;5;2;4;4;4;4;4;6;8;6;2;3;4;4;5;6;4;3;4;7;3;4;3;5;3; GO:0031974;GO:0043231;GO:0043233;GO:0044429;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044446;GO:0044444;GO:0005737;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0005759;GO:0005575;GO:0070013; membrane-enclosed lumen;intracellular membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasmic part;cytoplasm;mitochondrion;cell part;cell;intracellular;mitochondrial matrix;cellular_component;intracellular organelle lumen; 2;4;3;4;3;2;3;3;2;3;4;4;5;2;2;3;5;1;4; GO:0046872;GO:0051213;GO:0003674;GO:0005488;GO:0003824;GO:0016491;GO:0043169;GO:0016702;GO:0016701;GO:0043167; metal ion binding;dioxygenase activity;molecular_function;binding;catalytic activity;oxidoreductase activity;cation binding;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;ion binding; 5;4;1;2;2;3;4;5;4;3; K10252 IPR004294; Carotenoid oxygenase; mitochondria Hs13994325 1152.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q8N568 Serine/threonine-protein kinase DCLK2 OS=Homo sapiens OX=9606 GN=DCLK2 PE=1 SV=4 - [DCLK2_HUMAN] 0.978 0.994 0.722 1.187 0.948 2.6 0.983903421 nan 1.252109705 nan 0.726358149 nan 2.742616034 nan GO:0021537;GO:0048666;GO:0044707;GO:0030154;GO:0048468;GO:0021766;GO:0050789;GO:0060322;GO:0007165;GO:0021761;GO:0035556;GO:0044699;GO:0007417;GO:0051716;GO:0048869;GO:0007275;GO:0048513;GO:0065007;GO:0021954;GO:0021872;GO:0021953;GO:0032502;GO:0032501;GO:0030182;GO:0050794;GO:0044767;GO:0021543;GO:0008150;GO:0023052;GO:0021859;GO:0007154;GO:0022008;GO:0021884;GO:0044700;GO:0048699;GO:0007420;GO:0050896;GO:0048856;GO:0007399;GO:0044763;GO:0030900;GO:0021879;GO:0048731;GO:0009987;GO:0021860; telencephalon development;neuron development;single-multicellular organism process;cell differentiation;cell development;hippocampus development;regulation of biological process;head development;signal transduction;limbic system development;intracellular signal transduction;single-organism process;central nervous system development;cellular response to stimulus;cellular developmental process;multicellular organism development;animal organ development;biological regulation;central nervous system neuron development;forebrain generation of neurons;central nervous system neuron differentiation;developmental process;multicellular organismal process;neuron differentiation;regulation of cellular process;single-organism developmental process;pallium development;biological_process;signaling;pyramidal neuron differentiation;cell communication;neurogenesis;forebrain neuron development;single organism signaling;generation of neurons;brain development;response to stimulus;anatomical structure development;nervous system development;single-organism cellular process;forebrain development;forebrain neuron differentiation;system development;cellular process;pyramidal neuron development; 4;5;3;5;4;4;2;4;4;5;5;2;5;3;4;4;4;2;6;5;6;2;2;6;3;3;4;1;2;7;4;6;7;3;7;4;2;3;5;3;4;6;4;2;8; GO:0043229;GO:0043226;GO:0005737;GO:0005856;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043228;GO:0044424; intracellular organelle;organelle;cytoplasm;cytoskeleton;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;non-membrane-bounded organelle;intracellular part; 3;2;4;5;4;2;2;3;1;3;3; GO:0017076;GO:0005524;GO:0035639;GO:1901363;GO:0003674;GO:0001883;GO:0032550;GO:0043167;GO:0032549;GO:0036094;GO:0004674;GO:0016740;GO:1901265;GO:0004672;GO:0043168;GO:0001882;GO:0097367;GO:0000166;GO:0016301;GO:0032559;GO:0030554;GO:0032555;GO:0003824;GO:0016773;GO:0016772;GO:0097159;GO:0032553;GO:0005488; purine nucleotide binding;ATP binding;purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;purine nucleoside binding;purine ribonucleoside binding;ion binding;ribonucleoside binding;small molecule binding;protein serine/threonine kinase activity;transferase activity;nucleoside phosphate binding;protein kinase activity;anion binding;nucleoside binding;carbohydrate derivative binding;nucleotide binding;kinase activity;adenyl ribonucleotide binding;adenyl nucleotide binding;purine ribonucleotide binding;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;organic cyclic compound binding;ribonucleotide binding;binding; 5;6;5;3;1;5;6;3;5;3;7;3;4;6;4;4;3;4;5;6;6;5;2;5;4;3;4;2; K08805 IPR011009;IPR000719;IPR008271;IPR017441;IPR003533;IPR020636; Protein kinase-like domain;Protein kinase domain;Serine/threonine-protein kinase, active site;Protein kinase, ATP binding site;Doublecortin domain;Calcium/calmodulin-dependent/calcium-dependent protein kinase; nucleus Hs22043888 763.0 T [T] Signal transduction mechanisms; Q9BYV2 Tripartite motif-containing protein 54 OS=Homo sapiens OX=9606 GN=TRIM54 PE=1 SV=3 - [TRI54_HUMAN] 1.004 1.144 1.129 0.787 1.13 0.776 0.877622378 nan 0.696460177 nan 0.986888112 nan 0.686725664 nan GO:0031110;GO:0031111;GO:0031114;GO:0071840;GO:0051716;GO:0048869;GO:0051494;GO:0051493;GO:0048519;GO:0031109;GO:1901880;GO:0044700;GO:0044707;GO:0010639;GO:0070507;GO:0007165;GO:1901879;GO:0032886;GO:0016043;GO:0065007;GO:0044699;GO:0050794;GO:0008150;GO:0050896;GO:0022411;GO:0033043;GO:0030154;GO:0051129;GO:0051128;GO:0023052;GO:0043244;GO:0043241;GO:0043242;GO:0032502;GO:0032501;GO:0009987;GO:0007010;GO:0000226;GO:0043933;GO:0007275;GO:0032984;GO:0071822;GO:0007026;GO:0051261;GO:0050789;GO:0044767;GO:0044763;GO:0007154;GO:0043624;GO:0006996;GO:0007017;GO:0048856;GO:0007019;GO:1902589;GO:0048523; regulation of microtubule polymerization or depolymerization;negative regulation of microtubule polymerization or depolymerization;regulation of microtubule depolymerization;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;negative regulation of biological process;microtubule polymerization or depolymerization;negative regulation of protein depolymerization;single organism signaling;single-multicellular organism process;negative regulation of organelle organization;regulation of microtubule cytoskeleton organization;signal transduction;regulation of protein depolymerization;regulation of microtubule-based process;cellular component organization;biological regulation;single-organism process;regulation of cellular process;biological_process;response to stimulus;cellular component disassembly;regulation of organelle organization;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;signaling;regulation of protein complex disassembly;protein complex disassembly;negative regulation of protein complex disassembly;developmental process;multicellular organismal process;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;macromolecular complex subunit organization;multicellular organism development;macromolecular complex disassembly;protein complex subunit organization;negative regulation of microtubule depolymerization;protein depolymerization;regulation of biological process;single-organism developmental process;single-organism cellular process;cell communication;cellular protein complex disassembly;organelle organization;microtubule-based process;anatomical structure development;microtubule depolymerization;single-organism organelle organization;negative regulation of cellular process; 6;7;7;2;3;4;6;6;2;6;6;3;3;5;5;4;6;4;3;2;2;3;1;2;4;5;5;4;4;2;5;6;5;2;2;2;5;5;4;4;5;5;7;8;2;3;3;4;7;4;4;3;7;4;3; GO:0099513;GO:0099512;GO:0043234;GO:0043232;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043226;GO:0005856;GO:0005874;GO:0031674;GO:0044430;GO:0044446;GO:0044444;GO:0044449;GO:0030016;GO:0030017;GO:0005875;GO:0030018;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0015630;GO:0032991;GO:0005575;GO:0043292; polymeric cytoskeletal fiber;supramolecular fiber;protein complex;intracellular non-membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;organelle;cytoskeleton;microtubule;I band;cytoskeletal part;intracellular organelle part;cytoplasmic part;contractile fiber part;myofibril;sarcomere;microtubule associated complex;Z disc;cytoplasm;cell part;cell;intracellular;microtubule cytoskeleton;macromolecular complex;cellular_component;contractile fiber; 3;2;3;4;3;2;3;3;2;5;4;4;4;3;4;3;6;4;4;4;4;2;2;3;6;2;1;5; GO:0008270;GO:0046872;GO:0003674;GO:0005488;GO:0046914;GO:0043169;GO:0043167;GO:0004871; zinc ion binding;metal ion binding;molecular_function;binding;transition metal ion binding;cation binding;ion binding;signal transducer activity; 7;5;1;2;6;4;3;2; K10653 IPR033492;IPR013083;IPR027370;IPR017903;IPR000315;IPR001841;IPR017907; Tripartite motif-containing protein 54;Zinc finger, RING/FYVE/PHD-type;RING-type zinc-finger, LisH dimerisation motif;COS domain;B-box-type zinc finger;Zinc finger, RING-type;Zinc finger, RING-type, conserved site; nucleus Hs14211839 679.0 O [O] Posttranslational modification, protein turnover, chaperones; P01825 Immunoglobulin heavy variable 4-59 OS=Homo sapiens OX=9606 GN=IGHV4-59 PE=1 SV=2 - [HV459_HUMAN] 1.164 1.182 0.652 1.138 1.244 0.663 0.984771574 nan 0.914790997 nan 0.551607445 nan 0.532958199 nan GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; K06856 map04020;map04064;map04072;map04145;map04151;map04640;map04650;map04662;map04664;map04666;map04672;map05140;map05143;map05146;map05150;map05152;map05162;map05169;map05202;map05310;map05320;map05322;map05323;map05330;map05340;map05414;map05416; Calcium signaling pathway;NF-kappa B signaling pathway;Phospholipase D signaling pathway;Phagosome;PI3K-Akt signaling pathway;Hematopoietic cell lineage;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Intestinal immune network for IgA production;Leishmaniasis;African trypanosomiasis;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;Measles;Epstein-Barr virus infection;Transcriptional misregulation in cancer;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Primary immunodeficiency;Dilated cardiomyopathy;Viral myocarditis; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P01824 Immunoglobulin heavy variable 4-39 OS=Homo sapiens OX=9606 GN=IGHV4-39 PE=1 SV=2 - [HV439_HUMAN] 1.117 1.138 0.755 1.077 1.223 0.717 0.981546573 0.883828386 0.880621423 0.546692332 0.66344464 0.007909724 0.586263287 0.134631843 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; K06856 map04020;map04064;map04072;map04145;map04151;map04640;map04650;map04662;map04664;map04666;map04672;map05140;map05143;map05146;map05150;map05152;map05162;map05169;map05202;map05310;map05320;map05322;map05323;map05330;map05340;map05414;map05416; Calcium signaling pathway;NF-kappa B signaling pathway;Phospholipase D signaling pathway;Phagosome;PI3K-Akt signaling pathway;Hematopoietic cell lineage;Natural killer cell mediated cytotoxicity;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Intestinal immune network for IgA production;Leishmaniasis;African trypanosomiasis;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;Measles;Epstein-Barr virus infection;Transcriptional misregulation in cancer;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Primary immunodeficiency;Dilated cardiomyopathy;Viral myocarditis; IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P49711 Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1 - [CTCF_HUMAN] 1.216 1.157 0.792 0.897 0.94 1.594 1.05099395 0.613301445 0.954255319 0.747326507 0.684528954 0.136494474 1.695744681 0.190006325 GO:0006479;GO:0034728;GO:0035065;GO:0019222;GO:0006473;GO:0006475;GO:0006139;GO:0031056;GO:1901576;GO:0065003;GO:0071840;GO:0080090;GO:0006306;GO:0044710;GO:0006304;GO:0010605;GO:0010604;GO:0040029;GO:0018193;GO:0048518;GO:0048519;GO:0016570;GO:0016571;GO:0016573;GO:0060255;GO:0031060;GO:2001141;GO:0040030;GO:0046483;GO:0019538;GO:0018205;GO:0051254;GO:0019438;GO:0016568;GO:0071103;GO:0051252;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0010629;GO:0010628;GO:0050789;GO:0007063;GO:0007062;GO:0043543;GO:0031497;GO:0071514;GO:0044260;GO:1901362;GO:0016043;GO:0065007;GO:1901360;GO:1903308;GO:0006366;GO:0065009;GO:0032259;GO:0018130;GO:0018393;GO:0018394;GO:0007049;GO:0009889;GO:0006305;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:1901983;GO:0008152;GO:0034654;GO:0007059;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0043414;GO:0016569;GO:0010558;GO:0033044;GO:0033045;GO:0032774;GO:0044728;GO:0033043;GO:0010564;GO:0051128;GO:0044249;GO:0034641;GO:0022607;GO:0034645;GO:0006333;GO:0044699;GO:0010216;GO:0006349;GO:0070602;GO:0070601;GO:0000122;GO:0051246;GO:0031327;GO:0031399;GO:1903508;GO:0016584;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0045893;GO:0051983;GO:0008213;GO:0032268;GO:0000819;GO:0051253;GO:0098813;GO:0043170;GO:1902680;GO:0006807;GO:1902275;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0022402;GO:0071824;GO:0071822;GO:0006325;GO:2000112;GO:2000113;GO:0006323;GO:0071704;GO:0010467;GO:0010556;GO:0097659;GO:0010468;GO:0045935;GO:0045934;GO:0044267;GO:0019219;GO:0006464;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0006996;GO:0044238;GO:0051276;GO:0051726;GO:0044237;GO:1902589;GO:0044085;GO:0048523;GO:2000756;GO:0006259;GO:0048522; protein methylation;nucleosome organization;regulation of histone acetylation;regulation of metabolic process;protein acetylation;internal protein amino acid acetylation;nucleobase-containing compound metabolic process;regulation of histone modification;organic substance biosynthetic process;macromolecular complex assembly;cellular component organization or biogenesis;regulation of primary metabolic process;DNA methylation;single-organism metabolic process;DNA modification;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;regulation of gene expression, epigenetic;peptidyl-amino acid modification;positive regulation of biological process;negative regulation of biological process;histone modification;histone methylation;histone acetylation;regulation of macromolecule metabolic process;regulation of histone methylation;regulation of RNA biosynthetic process;regulation of molecular function, epigenetic;heterocycle metabolic process;protein metabolic process;peptidyl-lysine modification;positive regulation of RNA metabolic process;aromatic compound biosynthetic process;chromatin modification;DNA conformation change;regulation of RNA metabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;negative regulation of gene expression;positive regulation of gene expression;regulation of biological process;regulation of sister chromatid cohesion;sister chromatid cohesion;protein acylation;chromatin assembly;genetic imprinting;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;regulation of chromatin modification;transcription from RNA polymerase II promoter;regulation of molecular function;methylation;heterocycle biosynthetic process;internal peptidyl-lysine acetylation;peptidyl-lysine acetylation;cell cycle;regulation of biosynthetic process;DNA alkylation;regulation of cellular process;macromolecule modification;protein modification process;biological_process;regulation of protein acetylation;metabolic process;nucleobase-containing compound biosynthetic process;chromosome segregation;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;macromolecule methylation;covalent chromatin modification;negative regulation of macromolecule biosynthetic process;regulation of chromosome organization;regulation of sister chromatid segregation;RNA biosynthetic process;DNA methylation or demethylation;regulation of organelle organization;regulation of cell cycle process;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular component assembly;cellular macromolecule biosynthetic process;chromatin assembly or disassembly;single-organism process;maintenance of DNA methylation;regulation of gene expression by genetic imprinting;regulation of centromeric sister chromatid cohesion;centromeric sister chromatid cohesion;negative regulation of transcription from RNA polymerase II promoter;regulation of protein metabolic process;negative regulation of cellular biosynthetic process;regulation of protein modification process;positive regulation of nucleic acid-templated transcription;nucleosome positioning;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;regulation of chromosome segregation;protein alkylation;regulation of cellular protein metabolic process;sister chromatid segregation;negative regulation of RNA metabolic process;nuclear chromosome segregation;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;regulation of chromatin organization;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;protein-DNA complex subunit organization;protein complex subunit organization;chromatin organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;DNA packaging;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;nucleic acid-templated transcription;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;chromosome organization;regulation of cell cycle;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;negative regulation of cellular process;regulation of peptidyl-lysine acetylation;DNA metabolic process;positive regulation of cellular process; 5;6;6;3;8;9;4;5;4;5;2;4;5;3;6;4;4;6;7;2;2;4;5;5;4;6;6;4;4;4;8;5;5;6;6;5;3;3;4;4;5;5;2;6;5;7;6;5;4;5;3;2;4;7;7;3;3;5;10;9;4;4;7;3;5;5;1;7;2;5;4;5;5;6;5;7;6;4;7;5;6;5;6;7;5;5;4;4;4;4;5;6;2;6;6;7;6;7;5;5;6;7;7;2;4;7;7;6;6;4;7;5;5;5;5;4;6;3;6;5;4;5;4;4;4;5;4;5;5;5;6;6;7;3;5;5;7;5;5;5;5;5;6;6;3;5;3;4;4;4;4;3;5;4;3;4;3;3;8;5;3; GO:0031974;GO:0031981;GO:0044422;GO:0000793;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0005622;GO:0043227;GO:0005654;GO:0098687;GO:0005730;GO:0044446;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0043226;GO:0005694;GO:0000775;GO:0043228;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;organelle part;condensed chromosome;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;intracellular;membrane-bounded organelle;nucleoplasm;chromosomal region;nucleolus;intracellular organelle part;nucleus;cell part;intracellular organelle;cell;organelle;chromosome;chromosome, centromeric region;non-membrane-bounded organelle;cellular_component;intracellular organelle lumen; 2;5;2;6;4;4;3;4;3;4;3;3;5;5;5;3;5;2;3;2;2;5;6;3;1;4; GO:0043566;GO:0008270;GO:0001078;GO:1901363;GO:0003714;GO:0046872;GO:0003712;GO:0000988;GO:0001067;GO:0044212;GO:0001071;GO:0001012;GO:0001159;GO:0000989;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000987;GO:0000982;GO:0000981;GO:0097159;GO:0000976;GO:0000975;GO:0000978;GO:0043169;GO:1990837;GO:0043565;GO:0043167;GO:0003690;GO:0043035;GO:0001227;GO:0044877;GO:0003682;GO:0000977;GO:0003700;GO:0031490;GO:0001228;GO:0046914; structure-specific DNA binding;zinc ion binding;transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;heterocyclic compound binding;transcription corepressor activity;metal ion binding;transcription cofactor activity;transcription factor activity, protein binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;nucleic acid binding transcription factor activity;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;transcription factor activity, transcription factor binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter proximal region sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;cation binding;sequence-specific double-stranded DNA binding;sequence-specific DNA binding;ion binding;double-stranded DNA binding;chromatin insulator sequence binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;macromolecular complex binding;chromatin binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding;chromatin DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;transition metal ion binding; 6;7;6;3;5;5;4;2;5;7;2;8;8;3;1;2;4;5;9;5;4;3;8;6;10;4;7;6;3;6;6;5;3;4;9;3;5;5;6; K23195 IPR013087; Zinc finger C2H2-type; nucleus Hs5729790 1512.0 R [R] General function prediction only; O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens OX=9606 GN=ERN1 PE=1 SV=2 - [ERN1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0019220;GO:0019222;GO:0048584;GO:0048583;GO:0032147;GO:0070848;GO:0007165;GO:0034655;GO:0032774;GO:0023014;GO:0080090;GO:0051716;GO:0006986;GO:0045786;GO:0010604;GO:0009966;GO:0009967;GO:0000165;GO:0010467;GO:0018193;GO:0097659;GO:0071331;GO:0044093;GO:0071333;GO:0048518;GO:0048519;GO:0019725;GO:0070055;GO:0030969;GO:0060255;GO:0019439;GO:0045859;GO:0000394;GO:0046330;GO:0090501;GO:0023052;GO:2001141;GO:0010033;GO:0046483;GO:0042325;GO:0044700;GO:0042327;GO:0018209;GO:0030968;GO:0043406;GO:0019538;GO:0071322;GO:0034641;GO:0048878;GO:0033554;GO:0006379;GO:0035924;GO:0009894;GO:0098787;GO:0009893;GO:0033674;GO:0019438;GO:0031667;GO:0006397;GO:0010556;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0046700;GO:0044267;GO:1901575;GO:0044265;GO:0051347;GO:0044260;GO:1901362;GO:0043549;GO:0035966;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0018130;GO:0090305;GO:0006139;GO:0007049;GO:0050790;GO:0090304;GO:0044710;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:1901361;GO:0034654;GO:1902533;GO:1902531;GO:0051336;GO:0016071;GO:0044271;GO:0044270;GO:0012501;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0071326;GO:0009059;GO:0006351;GO:0032069;GO:0032107;GO:0032104;GO:0001678;GO:0032101;GO:0016310;GO:0043484;GO:0016070;GO:0051247;GO:0023056;GO:0043405;GO:0018105;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0046777;GO:0043408;GO:0007257;GO:0007254;GO:0008283;GO:0010562;GO:0051246;GO:0031098;GO:0009889;GO:0050673;GO:0032270;GO:0031399;GO:0008380;GO:0009746;GO:1901701;GO:0070302;GO:0016236;GO:0009987;GO:0006725;GO:0070304;GO:0032872;GO:0034645;GO:1903506;GO:0032874;GO:0036290;GO:0055082;GO:0009743;GO:0090502;GO:0042221;GO:0044699;GO:0032268;GO:0071363;GO:0051252;GO:0051254;GO:0043170;GO:0034284;GO:0035967;GO:0006807;GO:1990579;GO:0045860;GO:0080134;GO:0034976;GO:0000187;GO:0009991;GO:0080135;GO:0031329;GO:0031326;GO:0031325;GO:0031323;GO:0032075;GO:0097193;GO:0042592;GO:0042593;GO:0036498;GO:0022402;GO:0034620;GO:0046328;GO:0043506;GO:0043507;GO:0008219;GO:0070054;GO:0010628;GO:0007050;GO:0006355;GO:0010468;GO:1901360;GO:2000112;GO:0033500;GO:1900103;GO:0071704;GO:0071310;GO:0006987;GO:1901142;GO:0006401;GO:0006402;GO:0010506;GO:0009605;GO:0016241;GO:0036289;GO:0006468;GO:0045935;GO:0045937;GO:1901576;GO:0019219;GO:0006914;GO:0006915;GO:0006464;GO:0051174;GO:1900101;GO:0009058;GO:0051403;GO:0044763;GO:0051171;GO:0033120;GO:0051173;GO:0007154;GO:0070059;GO:0009056;GO:0009057;GO:0044248;GO:1901700;GO:0044238;GO:0051345;GO:0051726;GO:0001935;GO:0097190;GO:0044237;GO:0009749;GO:0006796;GO:0048523;GO:0006793;GO:0001932;GO:0044249;GO:0001934;GO:0006396;GO:0048522; regulation of phosphate metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;response to growth factor;signal transduction;nucleobase-containing compound catabolic process;RNA biosynthetic process;signal transduction by protein phosphorylation;regulation of primary metabolic process;cellular response to stimulus;response to unfolded protein;negative regulation of cell cycle;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;gene expression;peptidyl-amino acid modification;nucleic acid-templated transcription;cellular response to hexose stimulus;positive regulation of molecular function;cellular response to glucose stimulus;positive regulation of biological process;negative regulation of biological process;cellular homeostasis;mRNA endonucleolytic cleavage involved in unfolded protein response;mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response;regulation of macromolecule metabolic process;aromatic compound catabolic process;regulation of protein kinase activity;RNA splicing, via endonucleolytic cleavage and ligation;positive regulation of JNK cascade;RNA phosphodiester bond hydrolysis;signaling;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;peptidyl-serine modification;endoplasmic reticulum unfolded protein response;positive regulation of MAP kinase activity;protein metabolic process;cellular response to carbohydrate stimulus;cellular nitrogen compound metabolic process;chemical homeostasis;cellular response to stress;mRNA cleavage;cellular response to vascular endothelial growth factor stimulus;regulation of catabolic process;mRNA cleavage involved in mRNA processing;positive regulation of metabolic process;positive regulation of kinase activity;aromatic compound biosynthetic process;response to nutrient levels;mRNA processing;regulation of macromolecule biosynthetic process;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;heterocycle catabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;positive regulation of transferase activity;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of kinase activity;response to topologically incorrect protein;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;heterocycle biosynthetic process;nucleic acid phosphodiester bond hydrolysis;nucleobase-containing compound metabolic process;cell cycle;regulation of catalytic activity;nucleic acid metabolic process;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;metabolic process;organic cyclic compound catabolic process;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of hydrolase activity;mRNA metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;programmed cell death;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;cellular response to monosaccharide stimulus;macromolecule biosynthetic process;transcription, DNA-templated;regulation of nuclease activity;regulation of response to nutrient levels;regulation of response to extracellular stimulus;cellular glucose homeostasis;regulation of response to external stimulus;phosphorylation;regulation of RNA splicing;RNA metabolic process;positive regulation of protein metabolic process;positive regulation of signaling;regulation of MAP kinase activity;peptidyl-serine phosphorylation;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;protein autophosphorylation;regulation of MAPK cascade;activation of JUN kinase activity;JNK cascade;cell proliferation;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;regulation of biosynthetic process;epithelial cell proliferation;positive regulation of cellular protein metabolic process;regulation of protein modification process;RNA splicing;response to hexose;cellular response to oxygen-containing compound;regulation of stress-activated protein kinase signaling cascade;macroautophagy;cellular process;cellular aromatic compound metabolic process;positive regulation of stress-activated protein kinase signaling cascade;regulation of stress-activated MAPK cascade;cellular macromolecule biosynthetic process;regulation of nucleic acid-templated transcription;positive regulation of stress-activated MAPK cascade;protein trans-autophosphorylation;cellular chemical homeostasis;response to carbohydrate;RNA phosphodiester bond hydrolysis, endonucleolytic;response to chemical;single-organism process;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;response to monosaccharide;cellular response to topologically incorrect protein;nitrogen compound metabolic process;peptidyl-serine trans-autophosphorylation;positive regulation of protein kinase activity;regulation of response to stress;response to endoplasmic reticulum stress;activation of MAPK activity;response to extracellular stimulus;regulation of cellular response to stress;regulation of cellular catabolic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of nuclease activity;intrinsic apoptotic signaling pathway;homeostatic process;glucose homeostasis;IRE1-mediated unfolded protein response;cell cycle process;cellular response to unfolded protein;regulation of JNK cascade;regulation of JUN kinase activity;positive regulation of JUN kinase activity;cell death;mRNA splicing, via endonucleolytic cleavage and ligation;positive regulation of gene expression;cell cycle arrest;regulation of transcription, DNA-templated;regulation of gene expression;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;carbohydrate homeostasis;positive regulation of endoplasmic reticulum unfolded protein response;organic substance metabolic process;cellular response to organic substance;activation of signaling protein activity involved in unfolded protein response;insulin metabolic process;RNA catabolic process;mRNA catabolic process;regulation of autophagy;response to external stimulus;regulation of macroautophagy;peptidyl-serine autophosphorylation;protein phosphorylation;positive regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;autophagy;apoptotic process;cellular protein modification process;regulation of phosphorus metabolic process;regulation of endoplasmic reticulum unfolded protein response;biosynthetic process;stress-activated MAPK cascade;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of RNA splicing;positive regulation of nitrogen compound metabolic process;cell communication;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;catabolic process;macromolecule catabolic process;cellular catabolic process;response to oxygen-containing compound;primary metabolic process;positive regulation of hydrolase activity;regulation of cell cycle;endothelial cell proliferation;apoptotic signaling pathway;cellular metabolic process;response to glucose;phosphate-containing compound metabolic process;negative regulation of cellular process;phosphorus metabolic process;regulation of protein phosphorylation;cellular biosynthetic process;positive regulation of protein phosphorylation;RNA processing;positive regulation of cellular process; 6;3;3;3;9;5;4;5;6;4;4;3;5;4;4;4;4;5;5;7;7;8;4;7;2;2;4;8;7;4;5;7;8;8;6;2;6;4;4;7;3;7;8;5;7;4;6;4;5;4;7;7;4;8;3;7;5;5;7;5;9;5;8;2;5;5;4;5;6;4;5;6;4;2;5;3;3;5;6;4;4;4;5;3;3;6;5;5;1;2;5;5;5;5;5;6;5;5;5;2;6;3;5;7;5;6;5;6;5;6;4;6;6;5;5;3;7;8;4;3;4;4;8;6;8;7;3;5;5;5;4;4;5;6;7;7;5;5;4;2;4;6;6;5;7;7;9;5;5;7;3;2;5;6;5;5;4;6;5;3;10;8;4;5;8;4;4;5;5;4;4;5;6;4;7;6;4;6;7;8;8;4;8;5;5;6;5;4;6;6;5;3;5;6;5;6;7;4;3;5;9;7;5;6;4;5;3;6;6;5;5;3;6;3;4;6;4;4;6;3;5;4;4;3;6;4;5;5;3;8;5;3;4;7;4;7;6;3; GO:0005783;GO:0005789;GO:1990630;GO:0016021;GO:0016020;GO:0043234;GO:1990604;GO:1902494;GO:0098588;GO:0031965;GO:1902555;GO:0031967;GO:0031975;GO:0043231;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0030176;GO:0043227;GO:0031227;GO:0044432;GO:0012505;GO:0044446;GO:0044444;GO:1902911;GO:0005634;GO:1990332;GO:0042175;GO:0031301;GO:0031300;GO:0031224;GO:0005737;GO:0031090;GO:0005637;GO:0005635;GO:0005739;GO:0044464;GO:0005623;GO:1990597;GO:1990234;GO:0061695;GO:0043226;GO:0005622;GO:1902554;GO:0032991;GO:0005575;GO:0098796;GO:0019866; endoplasmic reticulum;endoplasmic reticulum membrane;IRE1-RACK1-PP2A complex;integral component of membrane;membrane;protein complex;IRE1-TRAF2-ASK1 complex;catalytic complex;bounding membrane of organelle;nuclear membrane;endoribonuclease complex;organelle envelope;envelope;intracellular membrane-bounded organelle;nuclear part;intracellular part;membrane part;organelle part;intracellular organelle;integral component of endoplasmic reticulum membrane;membrane-bounded organelle;intrinsic component of endoplasmic reticulum membrane;endoplasmic reticulum part;endomembrane system;intracellular organelle part;cytoplasmic part;protein kinase complex;nucleus;Ire1 complex;nuclear outer membrane-endoplasmic reticulum membrane network;integral component of organelle membrane;intrinsic component of organelle membrane;intrinsic component of membrane;cytoplasm;organelle membrane;nuclear inner membrane;nuclear envelope;mitochondrion;cell part;cell;AIP1-IRE1 complex;transferase complex;transferase complex, transferring phosphorus-containing groups;organelle;intracellular;serine/threonine protein kinase complex;macromolecular complex;cellular_component;membrane protein complex;organelle inner membrane; 4;3;4;4;2;3;4;4;4;4;5;4;3;4;4;3;2;2;3;4;3;4;4;3;3;4;7;5;4;3;4;3;3;4;3;5;4;5;2;2;4;5;6;2;3;8;2;1;3;4; GO:0004540;GO:1901363;GO:0004674;GO:0000166;GO:0016740;GO:0046872;GO:0004521;GO:0043169;GO:0097367;GO:0031072;GO:0036094;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0051879;GO:0005524;GO:0016787;GO:0016301;GO:0016788;GO:0003824;GO:0016773;GO:0016772;GO:0043168;GO:0032559;GO:0032555;GO:0046983;GO:0032553;GO:0000287;GO:0035639;GO:0019899;GO:0030544;GO:0043167;GO:0042802;GO:0042803;GO:0043531;GO:0030554;GO:0004518;GO:0004519;GO:0005515;GO:0097159;GO:0032550;GO:0001883;GO:0004672;GO:0001882; ribonuclease activity;heterocyclic compound binding;protein serine/threonine kinase activity;nucleotide binding;transferase activity;metal ion binding;endoribonuclease activity;cation binding;carbohydrate derivative binding;heat shock protein binding;small molecule binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;Hsp90 protein binding;ATP binding;hydrolase activity;kinase activity;hydrolase activity, acting on ester bonds;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;anion binding;adenyl ribonucleotide binding;purine ribonucleotide binding;protein dimerization activity;ribonucleotide binding;magnesium ion binding;purine ribonucleoside triphosphate binding;enzyme binding;Hsp70 protein binding;ion binding;identical protein binding;protein homodimerization activity;ADP binding;adenyl nucleotide binding;nuclease activity;endonuclease activity;protein binding;organic cyclic compound binding;purine ribonucleoside binding;purine nucleoside binding;protein kinase activity;nucleoside binding; 6;3;7;4;3;5;7;4;3;4;3;1;2;4;5;5;5;6;3;5;4;2;5;4;4;6;5;4;4;6;5;4;5;3;4;5;5;6;5;6;3;3;6;5;6;4; K08852 map04141;map04210;map04932;map05010; Protein processing in endoplasmic reticulum;Apoptosis;Non-alcoholic fatty liver disease (NAFLD);Alzheimer's disease; IPR011009;IPR000719;IPR008271;IPR018391;IPR018997;IPR011047;IPR010513; Protein kinase-like domain;Protein kinase domain;Serine/threonine-protein kinase, active site;Pyrrolo-quinoline quinone beta-propeller repeat;PUB domain;Quinoprotein alcohol dehydrogenase-like superfamily;KEN domain; plasma membrane Hs4557569 2015.0 T [T] Signal transduction mechanisms; A8CG34 Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3 - [P121C_HUMAN] 0.945 1.032 0.936 1.019 1.258 1.089 0.915697674 nan 0.810015898 nan 0.906976744 nan 0.865659777 nan GO:0006997;GO:0019221;GO:0019222;GO:0051049;GO:0034605;GO:0043412;GO:0048583;GO:0061024;GO:0008104;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0071705;GO:0051716;GO:0016925;GO:0010605;GO:0010256;GO:0071310;GO:0018193;GO:0044419;GO:0032446;GO:0016458;GO:0019058;GO:0051817;GO:0048519;GO:0051704;GO:0019054;GO:0034470;GO:0060255;GO:0071702;GO:0030397;GO:0045184;GO:0007077;GO:0051701;GO:0010033;GO:0046483;GO:0044700;GO:0019538;GO:0018205;GO:0033554;GO:0019438;GO:0044281;GO:0009892;GO:0019080;GO:0044068;GO:0019083;GO:0006807;GO:0044033;GO:0034660;GO:0051028;GO:0043170;GO:0050789;GO:0000278;GO:1901576;GO:0044260;GO:0008645;GO:0016043;GO:0008643;GO:0065007;GO:0065008;GO:0018130;GO:0034097;GO:0006810;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0009266;GO:0034654;GO:0051236;GO:0051234;GO:0016070;GO:0050658;GO:0044271;GO:0071345;GO:0050896;GO:0080135;GO:0044765;GO:0044764;GO:0044802;GO:0015931;GO:0032774;GO:0070647;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0007154;GO:0044699;GO:0006139;GO:0051081;GO:0051179;GO:0008033;GO:0009628;GO:0043687;GO:0009987;GO:0006725;GO:0009408;GO:0032879;GO:0055085;GO:0007049;GO:0033036;GO:1900034;GO:0010629;GO:0080134;GO:0019048;GO:1903047;GO:0050657;GO:0090304;GO:0010827;GO:0022402;GO:0006998;GO:0071840;GO:0015758;GO:0071704;GO:0010467;GO:0006403;GO:0010468;GO:0015749;GO:0044267;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0031047;GO:0042221;GO:0044003;GO:1902578;GO:0006996;GO:0044238;GO:0005975;GO:0044237;GO:0006399;GO:0016032;GO:0015031;GO:0044403;GO:0022411;GO:0035821;GO:0006396; nucleus organization;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of transport;cellular response to heat;macromolecule modification;regulation of response to stimulus;membrane organization;protein localization;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;nitrogen compound transport;cellular response to stimulus;protein sumoylation;negative regulation of macromolecule metabolic process;endomembrane system organization;cellular response to organic substance;peptidyl-amino acid modification;interspecies interaction between organisms;protein modification by small protein conjugation;gene silencing;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of biological process;multi-organism process;modulation by virus of host process;ncRNA processing;regulation of macromolecule metabolic process;organic substance transport;membrane disassembly;establishment of protein localization;mitotic nuclear envelope disassembly;interaction with host;response to organic substance;heterocycle metabolic process;single organism signaling;protein metabolic process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;small molecule metabolic process;negative regulation of metabolic process;viral gene expression;modulation by symbiont of host cellular process;viral transcription;nitrogen compound metabolic process;multi-organism metabolic process;ncRNA metabolic process;mRNA transport;macromolecule metabolic process;regulation of biological process;mitotic cell cycle;organic substance biosynthetic process;cellular macromolecule metabolic process;hexose transport;cellular component organization;carbohydrate transport;biological regulation;regulation of biological quality;heterocycle biosynthetic process;response to cytokine;transport;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;response to temperature stimulus;nucleobase-containing compound biosynthetic process;establishment of RNA localization;establishment of localization;RNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;single-organism transport;multi-organism cellular process;single-organism membrane organization;nucleobase-containing compound transport;RNA biosynthetic process;protein modification by small protein conjugation or removal;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;cell communication;single-organism process;nucleobase-containing compound metabolic process;nuclear envelope disassembly;localization;tRNA processing;response to abiotic stimulus;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;response to heat;regulation of localization;transmembrane transport;cell cycle;macromolecule localization;regulation of cellular response to heat;negative regulation of gene expression;regulation of response to stress;modulation by virus of host morphology or physiology;mitotic cell cycle process;nucleic acid transport;nucleic acid metabolic process;regulation of glucose transport;cell cycle process;nuclear envelope organization;cellular component organization or biogenesis;glucose transport;organic substance metabolic process;gene expression;RNA localization;regulation of gene expression;monosaccharide transport;cellular protein metabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;gene silencing by RNA;response to chemical;modification by symbiont of host morphology or physiology;single-organism localization;organelle organization;primary metabolic process;carbohydrate metabolic process;cellular metabolic process;tRNA metabolic process;viral process;protein transport;symbiosis, encompassing mutualism through parasitism;cellular component disassembly;modification of morphology or physiology of other organism;RNA processing; 5;6;3;4;5;5;3;4;4;4;5;5;4;5;3;9;4;4;5;7;3;8;4;5;4;2;2;5;7;4;5;5;4;6;4;4;4;3;4;8;4;5;4;3;4;4;5;3;3;6;6;4;2;5;4;4;7;3;5;2;3;5;5;4;3;3;3;5;1;2;4;5;4;3;5;5;5;6;2;4;4;3;4;6;6;7;4;4;2;4;4;2;4;6;2;8;3;7;2;4;4;3;4;4;3;5;5;4;5;5;7;5;5;4;5;2;8;3;5;4;5;6;5;6;3;5;3;5;3;5;3;4;3;4;3;7;4;5;4;4;3;6; GO:0005789;GO:0005783;GO:0016021;GO:0016020;GO:0098588;GO:0031965;GO:0031967;GO:0031975;GO:0043231;GO:0042175;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005622;GO:0005643;GO:0043226;GO:0044425;GO:0005575; endoplasmic reticulum membrane;endoplasmic reticulum;integral component of membrane;membrane;bounding membrane of organelle;nuclear membrane;organelle envelope;envelope;intracellular membrane-bounded organelle;nuclear outer membrane-endoplasmic reticulum membrane network;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;nucleus;nuclear envelope;cell part;cell;intracellular;nuclear pore;organelle;membrane part;cellular_component; 3;4;4;2;4;4;4;3;4;3;4;3;2;3;3;4;3;3;3;4;4;3;5;4;2;2;3;5;2;2;1; K14316 map03013; RNA transport; IPR026054;IPR026090; Nuclear pore complex protein;Nuclear pore protein POM121; plasma membrane Q7KZF4 Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1 - [SND1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:0001503;GO:1901362;GO:1901360;GO:0010605;GO:0048869;GO:0044419;GO:0016458;GO:0048519;GO:0051704;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0019438;GO:0009892;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0031047;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0044764;GO:0051252;GO:0010629;GO:0043170;GO:0031326;GO:0031323;GO:0090304;GO:0001649;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0044238;GO:0044237;GO:0016032;GO:0044403; regulation of primary metabolic process;regulation of metabolic process;ossification;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;cellular developmental process;interspecies interaction between organisms;gene silencing;negative regulation of biological process;multi-organism process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;negative regulation of metabolic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;gene silencing by RNA;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;multi-organism cellular process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;osteoblast differentiation;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;viral process;symbiosis, encompassing mutualism through parasitism; 4;3;4;5;4;4;4;3;4;2;2;4;6;4;3;5;3;3;7;4;4;2;5;4;3;1;2;5;5;5;6;5;6;5;6;5;4;4;5;2;4;2;2;2;4;7;3;5;5;4;5;4;5;5;6;2;3;5;5;5;3;3;5;3;4;3;3;4;4; GO:0048770;GO:0030529;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0043230;GO:0043231;GO:0044424;GO:0016442;GO:0044421;GO:1990904;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0097708;GO:0044444;GO:0005737;GO:0031410;GO:0005634;GO:0097433;GO:0005739;GO:0042470;GO:0031332;GO:0044464;GO:0005623;GO:0070062;GO:1903561;GO:0032991;GO:0005575;GO:0005576; pigment granule;intracellular ribonucleoprotein complex;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;RISC complex;extracellular region part;ribonucleoprotein complex;intracellular organelle;intracellular;membrane-bounded organelle;organelle;intracellular vesicle;cytoplasmic part;cytoplasm;cytoplasmic vesicle;nucleus;dense body;mitochondrion;melanosome;RNAi effector complex;cell part;cell;extracellular exosome;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 6;4;4;5;2;5;3;4;3;6;2;3;3;3;3;2;4;4;4;5;5;5;5;7;5;2;2;4;3;2;1;2; GO:1901363;GO:0003712;GO:0003674;GO:0005488;GO:0003676;GO:0000989;GO:0000988;GO:0016787;GO:0016788;GO:0003824;GO:0097159;GO:0004518;GO:0003723;GO:0044822; heterocyclic compound binding;transcription cofactor activity;molecular_function;binding;nucleic acid binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;organic cyclic compound binding;nuclease activity;RNA binding;poly(A) RNA binding; 3;4;1;2;4;3;2;3;4;2;3;5;5;6; K15979 map05169;map05203; Epstein-Barr virus infection;Viral carcinogenesis; IPR035437;IPR016685;IPR002999;IPR002071;IPR016071; Staphylococcal nuclease (SNase-like), OB-fold/extended TUDOR domain;RNA-induced silencing complex, nuclease component Tudor-SN;Tudor domain;Thermonuclease active site;Staphylococcal nuclease (SNase-like), OB-fold; cytosol Hs20543502 1874.0 K [K] Transcription; Q96QP1 Alpha-protein kinase 1 OS=Homo sapiens OX=9606 GN=ALPK1 PE=1 SV=3 - [ALPK1_HUMAN] 0.523 0.438 2.434 0.794 0.375 0.914 1.194063927 0.670338928 2.117333333 0.209637287 5.557077626 0.102936989 2.437333333 0.42338799 GO:0050688;GO:0032101;GO:0016236;GO:1903008;GO:0098779;GO:0050789;GO:0071840;GO:0044712;GO:0044710;GO:0043207;GO:0009615;GO:0002697;GO:0016043;GO:0098780;GO:0002682;GO:0007005;GO:0065007;GO:0051707;GO:0009605;GO:0061726;GO:0002831;GO:0006914;GO:0009987;GO:0051716;GO:0048583;GO:0050691;GO:0006952;GO:0006950;GO:0044763;GO:0008152;GO:0031347;GO:0009056;GO:0098542;GO:0051704;GO:0006996;GO:0044699;GO:0009607;GO:0051607;GO:0000422;GO:0000423;GO:0050896;GO:0043900;GO:0002376;GO:1902589;GO:0002230;GO:0098792;GO:0033554;GO:0002252;GO:0008150;GO:0022411;GO:0080134; regulation of defense response to virus;regulation of response to external stimulus;macroautophagy;organelle disassembly;mitophagy in response to mitochondrial depolarization;regulation of biological process;cellular component organization or biogenesis;single-organism catabolic process;single-organism metabolic process;response to external biotic stimulus;response to virus;regulation of immune effector process;cellular component organization;response to mitochondrial depolarisation;regulation of immune system process;mitochondrion organization;biological regulation;response to other organism;response to external stimulus;mitochondrion disassembly;regulation of response to biotic stimulus;autophagy;cellular process;cellular response to stimulus;regulation of response to stimulus;regulation of defense response to virus by host;defense response;response to stress;single-organism cellular process;metabolic process;regulation of defense response;catabolic process;defense response to other organism;multi-organism process;organelle organization;single-organism process;response to biotic stimulus;defense response to virus;mitophagy;macromitophagy;response to stimulus;regulation of multi-organism process;immune system process;single-organism organelle organization;positive regulation of defense response to virus by host;xenophagy;cellular response to stress;immune effector process;biological_process;cellular component disassembly;regulation of response to stress; 4;4;4;5;6;2;2;4;3;4;4;4;3;5;3;5;2;3;3;6;4;3;2;3;3;5;4;3;3;2;5;3;4;2;4;2;3;4;4;5;2;3;2;4;6;5;4;3;1;4;4; GO:1901363;GO:0035639;GO:0003674;GO:0005488;GO:0001883;GO:0000166;GO:0001882;GO:0043167;GO:0004674;GO:0016740;GO:0004672;GO:0032549;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0017076;GO:0036094;GO:0016773;GO:0016772;GO:0030554;GO:0032550;GO:0097367;GO:0032559;GO:0032555;GO:0097159;GO:0032553;GO:1901265; heterocyclic compound binding;purine ribonucleoside triphosphate binding;molecular_function;binding;purine nucleoside binding;nucleotide binding;nucleoside binding;ion binding;protein serine/threonine kinase activity;transferase activity;protein kinase activity;ribonucleoside binding;ATP binding;anion binding;kinase activity;catalytic activity;purine nucleotide binding;small molecule binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl nucleotide binding;purine ribonucleoside binding;carbohydrate derivative binding;adenyl ribonucleotide binding;purine ribonucleotide binding;organic cyclic compound binding;ribonucleotide binding;nucleoside phosphate binding; 3;5;1;2;5;4;4;3;7;3;6;5;6;4;5;2;5;3;5;4;6;6;3;6;5;3;4;4; K08868 IPR004166;IPR011009; MHCK/EF2 kinase;Protein kinase-like domain; endoplasmic reticulum Hs21361969_2 2261.0 T [T] Signal transduction mechanisms; Q9NW13 RNA-binding protein 28 OS=Homo sapiens OX=9606 GN=RBM28 PE=1 SV=3 - [RBM28_HUMAN] 0.903 0.713 1.645 0.833 0.768 1.56 1.266479663 nan 1.084635417 nan 2.307152875 nan 2.03125 nan GO:0044237;GO:0090304;GO:0006396;GO:0016071;GO:0071704;GO:0010467;GO:1901360;GO:0008380;GO:0043170;GO:0006139;GO:0009987;GO:0006725;GO:0044260;GO:0008150;GO:0008152;GO:0046483;GO:0016070;GO:0044238;GO:0034641;GO:0006807;GO:0006397; cellular metabolic process;nucleic acid metabolic process;RNA processing;mRNA metabolic process;organic substance metabolic process;gene expression;organic cyclic compound metabolic process;RNA splicing;macromolecule metabolic process;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;cellular macromolecule metabolic process;biological_process;metabolic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;mRNA processing; 3;5;6;6;3;5;4;7;4;4;2;4;4;1;2;4;5;3;4;3;7; GO:0031974;GO:0043229;GO:0043228;GO:1990904;GO:0043227;GO:0043226;GO:0044446;GO:0031981;GO:0005730;GO:0005634;GO:0005681;GO:0030529;GO:0032991;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;ribonucleoprotein complex;membrane-bounded organelle;organelle;intracellular organelle part;nuclear lumen;nucleolus;nucleus;spliceosomal complex;intracellular ribonucleoprotein complex;macromolecular complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;3;3;3;2;3;5;5;5;5;4;2;4;4;3;2;2;3;1;4;4;3;2; GO:0003674;GO:0005488;GO:0003676;GO:0000166;GO:1901265;GO:1901363;GO:0044822;GO:0036094;GO:0097159;GO:0003723; molecular_function;binding;nucleic acid binding;nucleotide binding;nucleoside phosphate binding;heterocyclic compound binding;poly(A) RNA binding;small molecule binding;organic cyclic compound binding;RNA binding; 1;2;4;4;4;3;6;3;3;5; K14573 map03008; Ribosome biogenesis in eukaryotes; IPR000504; RNA recognition motif domain; nucleus Hs8922388 1544.0 A [A] RNA processing and modification; Q6YP21 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1 - [KAT3_HUMAN] 0.874 1.015 1.276 0.931 0.962 1.258 0.861083744 nan 0.967775468 nan 1.257142857 nan 1.307692308 nan GO:0043436;GO:0044281;GO:0044282;GO:1901360;GO:1901361;GO:0044712;GO:0044710;GO:0042537;GO:0019439;GO:0009074;GO:0009072;GO:0046483;GO:0043648;GO:1901564;GO:1901565;GO:0006576;GO:0016054;GO:0042402;GO:0009063;GO:0006807;GO:1901575;GO:0070189;GO:0006569;GO:0006568;GO:0009308;GO:0006586;GO:0008150;GO:0008152;GO:0042436;GO:0042430;GO:0006575;GO:0044270;GO:0006103;GO:0009310;GO:0044248;GO:0034641;GO:0044699;GO:1901605;GO:1901606;GO:0009987;GO:0006725;GO:0044106;GO:0006082;GO:0046700;GO:0046395;GO:0019752;GO:0006520;GO:0071704;GO:0009058;GO:0044763;GO:0046218;GO:0009056;GO:0044238;GO:0042180;GO:0044237; oxoacid metabolic process;small molecule metabolic process;small molecule catabolic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism catabolic process;single-organism metabolic process;benzene-containing compound metabolic process;aromatic compound catabolic process;aromatic amino acid family catabolic process;aromatic amino acid family metabolic process;heterocycle metabolic process;dicarboxylic acid metabolic process;organonitrogen compound metabolic process;organonitrogen compound catabolic process;cellular biogenic amine metabolic process;organic acid catabolic process;cellular biogenic amine catabolic process;cellular amino acid catabolic process;nitrogen compound metabolic process;organic substance catabolic process;kynurenine metabolic process;tryptophan catabolic process;tryptophan metabolic process;amine metabolic process;indolalkylamine metabolic process;biological_process;metabolic process;indole-containing compound catabolic process;indole-containing compound metabolic process;cellular modified amino acid metabolic process;cellular nitrogen compound catabolic process;2-oxoglutarate metabolic process;amine catabolic process;cellular catabolic process;cellular nitrogen compound metabolic process;single-organism process;alpha-amino acid metabolic process;alpha-amino acid catabolic process;cellular process;cellular aromatic compound metabolic process;cellular amine metabolic process;organic acid metabolic process;heterocycle catabolic process;carboxylic acid catabolic process;carboxylic acid metabolic process;cellular amino acid metabolic process;organic substance metabolic process;biosynthetic process;single-organism cellular process;indolalkylamine catabolic process;catabolic process;primary metabolic process;cellular ketone metabolic process;cellular metabolic process; 5;4;5;4;5;4;3;5;5;6;5;4;7;4;5;6;5;7;5;3;4;5;7;6;5;6;1;2;6;5;4;5;8;6;4;4;2;5;6;2;4;5;4;5;6;6;4;3;3;3;7;3;3;4;3; GO:0043231;GO:0044424;GO:0043229;GO:0005623;GO:0043227;GO:0043226;GO:0044444;GO:0005737;GO:0005739;GO:0044464;GO:0005622;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;cell;membrane-bounded organelle;organelle;cytoplasmic part;cytoplasm;mitochondrion;cell part;intracellular;cellular_component; 4;3;3;2;3;2;4;4;5;2;3;1; GO:0030170;GO:0016212;GO:0047804;GO:1901363;GO:0016740;GO:0008483;GO:0003674;GO:0003676;GO:0016769;GO:0043168;GO:0003824;GO:0097159;GO:0016829;GO:0043167;GO:0047315;GO:0044822;GO:0048037;GO:0036137;GO:0003723;GO:0005488;GO:0016846; pyridoxal phosphate binding;kynurenine-oxoglutarate transaminase activity;cysteine-S-conjugate beta-lyase activity;heterocyclic compound binding;transferase activity;transaminase activity;molecular_function;nucleic acid binding;transferase activity, transferring nitrogenous groups;anion binding;catalytic activity;organic cyclic compound binding;lyase activity;ion binding;kynurenine-glyoxylate transaminase activity;poly(A) RNA binding;cofactor binding;kynurenine aminotransferase activity;RNA binding;binding;carbon-sulfur lyase activity; 4;7;5;3;3;5;1;4;4;4;2;3;3;3;7;6;3;6;5;2;4; K00816 map00380;map00450;map01100;map05204; Tryptophan metabolism;Selenocompound metabolism;Metabolic pathways;Chemical carcinogenesis; IPR015424;IPR015422;IPR004839;IPR034612;IPR015421; Pyridoxal phosphate-dependent transferase;Pyridoxal phosphate-dependent transferase, subdomain 2;Aminotransferase, class I/classII;Kynurenine--oxoglutarate transaminase 3;Pyridoxal phosphate-dependent transferase, major region, subdomain 1; mitochondria Hs4757928 479.0 E [E] Amino acid transport and metabolism; Q0IIM8 TBC1 domain family member 8B OS=Homo sapiens OX=9606 GN=TBC1D8B PE=1 SV=2 - [TBC8B_HUMAN] 2.018 0.621 0.533 2.016 0.489 nan 3.249597424 nan 4.122699387 nan 0.858293076 nan nan nan GO:0005488;GO:0043169;GO:0046872;GO:0030234;GO:0005096;GO:0043167;GO:0030695;GO:0003674;GO:0008047;GO:0098772;GO:0060589;GO:0005509; binding;cation binding;metal ion binding;enzyme regulator activity;GTPase activator activity;ion binding;GTPase regulator activity;molecular_function;enzyme activator activity;molecular function regulator;nucleoside-triphosphatase regulator activity;calcium ion binding; 2;4;5;3;5;3;5;1;4;2;4;6; K19951 IPR011992;IPR000195;IPR002048;IPR004182; EF-hand domain pair;Rab-GTPase-TBC domain;EF-hand domain;GRAM domain; cytosol Hs17485595 1636.0 R [R] General function prediction only; Q9P0V3 SH3 domain-binding protein 4 OS=Homo sapiens OX=9606 GN=SH3BP4 PE=1 SV=1 - [SH3B4_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0008104;GO:0019222;GO:0048585;GO:0048583;GO:0007165;GO:0071840;GO:0043200;GO:0051716;GO:0009968;GO:0070727;GO:0009966;GO:0071310;GO:0044092;GO:0048518;GO:0048519;GO:0033036;GO:0042127;GO:0042221;GO:0072665;GO:0010033;GO:0016192;GO:0044700;GO:0010243;GO:0010648;GO:0009896;GO:0009894;GO:0009893;GO:0035556;GO:0050789;GO:0016049;GO:0051346;GO:0016043;GO:0065007;GO:0065009;GO:0009719;GO:0050790;GO:0006810;GO:0034260;GO:0050794;GO:0008150;GO:0008152;GO:1902532;GO:0051234;GO:0051336;GO:0006897;GO:0050896;GO:1901699;GO:0071417;GO:0032007;GO:0032006;GO:0030308;GO:0051128;GO:0044248;GO:0023057;GO:0023052;GO:0070887;GO:0023051;GO:0010646;GO:0043087;GO:0043086;GO:0044699;GO:1902531;GO:0051641;GO:0071495;GO:0008285;GO:0008283;GO:0031331;GO:0009987;GO:0031929;GO:0061462;GO:0001558;GO:0001101;GO:0033365;GO:1901698;GO:0045926;GO:0031329;GO:0031325;GO:0031323;GO:0071229;GO:0040008;GO:0010508;GO:0010506;GO:0071230;GO:0006914;GO:0034613;GO:0044763;GO:0007154;GO:0009056;GO:0051179;GO:0040007;GO:1901700;GO:1901701;GO:0044237;GO:0048523;GO:0048522; protein localization;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;cellular component organization or biogenesis;response to amino acid;cellular response to stimulus;negative regulation of signal transduction;cellular macromolecule localization;regulation of signal transduction;cellular response to organic substance;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;macromolecule localization;regulation of cell proliferation;response to chemical;protein localization to vacuole;response to organic substance;vesicle-mediated transport;single organism signaling;response to organonitrogen compound;negative regulation of cell communication;positive regulation of catabolic process;regulation of catabolic process;positive regulation of metabolic process;intracellular signal transduction;regulation of biological process;cell growth;negative regulation of hydrolase activity;cellular component organization;biological regulation;regulation of molecular function;response to endogenous stimulus;regulation of catalytic activity;transport;negative regulation of GTPase activity;regulation of cellular process;biological_process;metabolic process;negative regulation of intracellular signal transduction;establishment of localization;regulation of hydrolase activity;endocytosis;response to stimulus;cellular response to nitrogen compound;cellular response to organonitrogen compound;negative regulation of TOR signaling;regulation of TOR signaling;negative regulation of cell growth;regulation of cellular component organization;cellular catabolic process;negative regulation of signaling;signaling;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;regulation of GTPase activity;negative regulation of catalytic activity;single-organism process;regulation of intracellular signal transduction;cellular localization;cellular response to endogenous stimulus;negative regulation of cell proliferation;cell proliferation;positive regulation of cellular catabolic process;cellular process;TOR signaling;protein localization to lysosome;regulation of cell growth;response to acid chemical;protein localization to organelle;response to nitrogen compound;negative regulation of growth;regulation of cellular catabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;cellular response to acid chemical;regulation of growth;positive regulation of autophagy;regulation of autophagy;cellular response to amino acid stimulus;autophagy;cellular protein localization;single-organism cellular process;cell communication;catabolic process;localization;growth;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;3;4;2;5;3;4;4;4;5;4;2;2;3;4;3;7;4;5;3;4;4;4;4;3;5;2;3;6;3;2;3;3;4;4;3;3;1;2;5;3;5;6;2;5;5;6;6;4;4;4;3;2;4;3;4;6;5;2;5;3;4;4;3;5;2;6;8;4;4;6;4;3;5;4;4;5;3;4;4;6;3;5;3;4;3;2;2;4;5;3;3;3; GO:0031982;GO:0016020;GO:0031988;GO:0098589;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0043229;GO:0043227;GO:0012505;GO:0016023;GO:0044444;GO:0097708;GO:0005905;GO:0005737;GO:0031410;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0030135;GO:0030136;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576;GO:0098805; vesicle;membrane;membrane-bounded vesicle;membrane region;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;intracellular organelle;membrane-bounded organelle;endomembrane system;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;intracellular vesicle;coated pit;cytoplasm;cytoplasmic vesicle;nucleus;cell part;cell;intracellular;coated vesicle;clathrin-coated vesicle;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region;whole membrane; 4;2;5;3;3;4;3;2;2;3;3;3;5;4;4;3;4;5;5;2;2;3;6;7;4;2;3;1;2;3; GO:0031267;GO:0098772;GO:0005092;GO:0030695;GO:0017016;GO:0003674;GO:0005488;GO:0030234;GO:0019899;GO:0042802;GO:0060589;GO:0051020;GO:0005515; small GTPase binding;molecular function regulator;GDP-dissociation inhibitor activity;GTPase regulator activity;Ras GTPase binding;molecular_function;binding;enzyme regulator activity;enzyme binding;identical protein binding;nucleoside-triphosphatase regulator activity;GTPase binding;protein binding; 6;2;6;5;7;1;2;3;4;4;4;5;3; K20066 IPR035455;IPR001452;IPR011511;IPR000906;IPR035456; SH3 domain-binding protein 4;SH3 domain;Variant SH3 domain;ZU5 domain;SH3BP4, SH3 domain; nucleus Q7LBC6 Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2 - [KDM3B_HUMAN] 0.964 0.952 0.967 1.05 0.887 2.265 1.012605042 0.870192495 1.183765502 0.14924903 1.015756303 0.810707079 2.553551297 0.134347244 GO:0080090;GO:0019222;GO:1901362;GO:0071840;GO:0072718;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0016568;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:1901360;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0009987;GO:0006725;GO:1903506;GO:0051252;GO:0043170;GO:0043933;GO:0031326;GO:1990267;GO:0031323;GO:0090304;GO:0006325;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0009058;GO:0009059;GO:0051171;GO:0042221;GO:0006996;GO:0044238;GO:0051276;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;response to cisplatin;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;chromatin modification;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of RNA metabolic process;macromolecule metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;response to transition metal nanoparticle;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;response to chemical;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process; 4;3;5;2;5;4;6;4;5;6;3;7;4;4;3;2;4;5;4;3;1;2;5;5;5;2;6;5;6;6;4;4;5;4;2;4;7;5;4;4;5;4;4;5;5;6;2;3;5;5;5;3;5;4;3;4;3;5;3; GO:0031974;GO:0031981;GO:0044422;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;organelle part;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;2;4;3;4;3;3;3;3;2;5;3;5;2;2;1;4; GO:0046872;GO:0016209;GO:0051213;GO:0003674;GO:0005488;GO:0043169;GO:0003824;GO:0016491;GO:0043167; metal ion binding;antioxidant activity;dioxygenase activity;molecular_function;binding;cation binding;catalytic activity;oxidoreductase activity;ion binding; 5;2;4;1;2;4;2;3;3; K15601 IPR003347; JmjC domain; nucleus Hs22046864_2 3388.0 K [K] Transcription; Q9P2X7 Deleted in esophageal cancer 1 OS=Homo sapiens OX=9606 GN=DEC1 PE=2 SV=1 - [DEC1_HUMAN] 1.123 1.125 0.612 1.134 1.253 1.163 0.998222222 nan 0.905027933 nan 0.544 nan 0.928172386 nan GO:0042127;GO:0008285;GO:0008283;GO:0009987;GO:0050794;GO:0008150;GO:0065007;GO:0044699;GO:0048519;GO:0050789;GO:0048523; regulation of cell proliferation;negative regulation of cell proliferation;cell proliferation;cellular process;regulation of cellular process;biological_process;biological regulation;single-organism process;negative regulation of biological process;regulation of biological process;negative regulation of cellular process; 4;4;3;2;3;1;2;2;2;2;3; IPR031718; Deleted in esophageal cancer 1; cytosol Q5JTZ9 Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1 - [SYAM_HUMAN] 1.056 1.215 0.521 1.513 1.097 0.975 0.869135802 nan 1.379216044 nan 0.428806584 nan 0.888787603 nan GO:0009451;GO:0044281;GO:0071840;GO:0043043;GO:0034470;GO:0043436;GO:0046483;GO:1901564;GO:0006082;GO:1901566;GO:0019538;GO:0043038;GO:0043039;GO:0022607;GO:0006807;GO:0034660;GO:0044267;GO:0044260;GO:0016043;GO:0065003;GO:1901360;GO:0032543;GO:0044710;GO:0043412;GO:0044711;GO:0008150;GO:0008152;GO:0016070;GO:0044271;GO:0006518;GO:0070271;GO:0044249;GO:0034641;GO:0034645;GO:0007005;GO:0044699;GO:0006139;GO:0033108;GO:0008033;GO:0009987;GO:0006725;GO:0070143;GO:0043604;GO:0043603;GO:0043170;GO:0000959;GO:0043933;GO:0019752;GO:0090304;GO:0034622;GO:0071822;GO:0006520;GO:0071704;GO:0010467;GO:0006400;GO:0070127;GO:1901576;GO:0006461;GO:0009058;GO:0009059;GO:0044763;GO:0043623;GO:0006996;GO:0044238;GO:0044237;GO:0006399;GO:1902589;GO:0044085;GO:0006419;GO:0006418;GO:0006412;GO:0006396; RNA modification;small molecule metabolic process;cellular component organization or biogenesis;peptide biosynthetic process;ncRNA processing;oxoacid metabolic process;heterocycle metabolic process;organonitrogen compound metabolic process;organic acid metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;amino acid activation;tRNA aminoacylation;cellular component assembly;nitrogen compound metabolic process;ncRNA metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;organic cyclic compound metabolic process;mitochondrial translation;single-organism metabolic process;macromolecule modification;single-organism biosynthetic process;biological_process;metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;peptide metabolic process;protein complex biogenesis;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;mitochondrion organization;single-organism process;nucleobase-containing compound metabolic process;mitochondrial respiratory chain complex assembly;tRNA processing;cellular process;cellular aromatic compound metabolic process;mitochondrial alanyl-tRNA aminoacylation;amide biosynthetic process;cellular amide metabolic process;macromolecule metabolic process;mitochondrial RNA metabolic process;macromolecular complex subunit organization;carboxylic acid metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;protein complex subunit organization;cellular amino acid metabolic process;organic substance metabolic process;gene expression;tRNA modification;tRNA aminoacylation for mitochondrial protein translation;organic substance biosynthetic process;protein complex assembly;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cellular protein complex assembly;organelle organization;primary metabolic process;cellular metabolic process;tRNA metabolic process;single-organism organelle organization;cellular component biogenesis;alanyl-tRNA aminoacylation;tRNA aminoacylation for protein translation;translation;RNA processing; 6;4;2;6;7;5;4;4;4;5;4;5;6;4;3;6;5;4;3;5;4;5;3;5;4;1;2;5;5;5;4;4;4;5;5;2;4;6;8;2;4;7;6;5;4;6;4;6;5;6;5;4;3;5;7;6;4;5;3;5;3;6;4;3;3;7;4;3;8;7;6;6; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044444;GO:0005737;GO:0005739;GO:0044464;GO:0005623;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasmic part;cytoplasm;mitochondrion;cell part;cell;cellular_component; 4;3;3;3;3;2;4;4;5;2;2;1; GO:0016597;GO:1901363;GO:0004813;GO:0004812;GO:0000166;GO:0046872;GO:0097367;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0043169;GO:0003824;GO:0097159;GO:0031406;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0000049;GO:0016874;GO:0043167;GO:0030554;GO:0043177;GO:0003723;GO:0001883;GO:0001882;GO:0036094;GO:0016875;GO:0016876; amino acid binding;heterocyclic compound binding;alanine-tRNA ligase activity;aminoacyl-tRNA ligase activity;nucleotide binding;metal ion binding;carbohydrate derivative binding;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;cation binding;catalytic activity;organic cyclic compound binding;carboxylic acid binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;tRNA binding;ligase activity;ion binding;adenyl nucleotide binding;organic acid binding;RNA binding;purine nucleoside binding;nucleoside binding;small molecule binding;ligase activity, forming carbon-oxygen bonds;ligase activity, forming aminoacyl-tRNA and related compounds; 6;3;7;6;4;5;3;1;2;4;4;5;5;6;4;4;2;3;5;6;5;6;4;5;6;3;3;6;4;5;5;4;3;4;5; K01872 map00970; Aminoacyl-tRNA biosynthesis; IPR018164;IPR018165;IPR018162;IPR018163;IPR009000;IPR012947;IPR023033;IPR002318; Alanyl-tRNA synthetase, class IIc, N-terminal;Alanyl-tRNA synthetase, class IIc, core domain;Alanine-tRNA ligase, class IIc, anti-codon-binding domain;Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain;Translation protein, beta-barrel domain;Threonyl/alanyl tRNA synthetase, SAD;Alanine-tRNA ligase, eukaryota/bacteria;Alanine-tRNA ligase, class IIc; mitochondria Hs20555071 2006.0 J [J] Translation, ribosomal structure and biogenesis; P82094 TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2 - [TMF1_HUMAN] 1.035 1.157 0.99 0.898 1.169 0.754 0.894554883 0.003074568 0.76817793 0.009884743 0.855661193 0.016073033 0.644995723 0.004923376 GO:0033327;GO:0051047;GO:0051049;GO:0007286;GO:0048468;GO:0008584;GO:0001816;GO:2000831;GO:2000833;GO:0032989;GO:1901362;GO:1901360;GO:0080090;GO:0051716;GO:0010605;GO:0000003;GO:0043207;GO:0048869;GO:0071840;GO:0010256;GO:0071310;GO:0045137;GO:0046879;GO:0048513;GO:0048515;GO:0048518;GO:0048519;GO:0003008;GO:0035936;GO:0035935;GO:0051050;GO:0060255;GO:0060548;GO:0007281;GO:0003006;GO:0007283;GO:0032268;GO:0010876;GO:0030163;GO:2001141;GO:0007289;GO:0010927;GO:0051707;GO:0010033;GO:0046483;GO:0044700;GO:0044703;GO:0044702;GO:0009607;GO:0044707;GO:0048870;GO:0019538;GO:0042176;GO:0016050;GO:0035929;GO:0010629;GO:0019438;GO:0060986;GO:0009894;GO:0022607;GO:0009892;GO:0070887;GO:0015850;GO:0023051;GO:0006928;GO:0006807;GO:0042742;GO:0050789;GO:0097659;GO:0009605;GO:1901576;GO:1901575;GO:0009653;GO:0044260;GO:0008406;GO:0016043;GO:2000834;GO:0065007;GO:0014070;GO:0006366;GO:0065008;GO:0048646;GO:0018130;GO:0043067;GO:0046546;GO:0006810;GO:0009889;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0051234;GO:1903050;GO:0046661;GO:0050886;GO:0016070;GO:0051603;GO:0007548;GO:0044271;GO:0032368;GO:0050896;GO:0010498;GO:0044765;GO:0006355;GO:0010556;GO:0006351;GO:0051046;GO:0001819;GO:0051240;GO:0009617;GO:0032774;GO:0006869;GO:0044265;GO:0030154;GO:0019953;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:1903530;GO:0034645;GO:0007154;GO:0010647;GO:0010646;GO:0044699;GO:0006139;GO:0001675;GO:0044057;GO:0051246;GO:0032370;GO:0009057;GO:0032274;GO:0032275;GO:1903532;GO:0044248;GO:0006508;GO:0032502;GO:0040011;GO:0046887;GO:0032501;GO:0048608;GO:0048609;GO:0032504;GO:0006997;GO:0030317;GO:0009987;GO:0006725;GO:0046903;GO:1903506;GO:0046883;GO:0098542;GO:0048232;GO:0044257;GO:0032879;GO:0033036;GO:0044060;GO:2000845;GO:0071407;GO:0051252;GO:0032940;GO:0043170;GO:0051239;GO:0001817;GO:0051674;GO:0031329;GO:0048731;GO:0033363;GO:0060341;GO:0061458;GO:0031326;GO:0031323;GO:0090304;GO:0008219;GO:0010941;GO:0007275;GO:0007276;GO:2000836;GO:0042981;GO:2000112;GO:0071704;GO:0010467;GO:0043066;GO:0071702;GO:0051704;GO:0043069;GO:0010468;GO:2000843;GO:1903362;GO:0044267;GO:0019219;GO:0061136;GO:0006915;GO:0023061;GO:0010817;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0022412;GO:0007267;GO:0042221;GO:0019222;GO:0070925;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0048856;GO:0044237;GO:0009914;GO:1902589;GO:0044085;GO:0030162;GO:0048523;GO:0048522; Leydig cell differentiation;positive regulation of secretion;regulation of transport;spermatid development;cell development;male gonad development;cytokine production;regulation of steroid hormone secretion;positive regulation of steroid hormone secretion;cellular component morphogenesis;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of primary metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;reproduction;response to external biotic stimulus;cellular developmental process;cellular component organization or biogenesis;endomembrane system organization;cellular response to organic substance;development of primary sexual characteristics;hormone secretion;animal organ development;spermatid differentiation;positive regulation of biological process;negative regulation of biological process;system process;testosterone secretion;androgen secretion;positive regulation of transport;regulation of macromolecule metabolic process;negative regulation of cell death;germ cell development;developmental process involved in reproduction;spermatogenesis;regulation of cellular protein metabolic process;lipid localization;protein catabolic process;regulation of RNA biosynthetic process;spermatid nucleus differentiation;cellular component assembly involved in morphogenesis;response to other organism;response to organic substance;heterocycle metabolic process;single organism signaling;multi-organism reproductive process;single organism reproductive process;response to biotic stimulus;single-multicellular organism process;cell motility;protein metabolic process;regulation of protein catabolic process;vesicle organization;steroid hormone secretion;negative regulation of gene expression;aromatic compound biosynthetic process;endocrine hormone secretion;regulation of catabolic process;cellular component assembly;negative regulation of metabolic process;cellular response to chemical stimulus;organic hydroxy compound transport;regulation of signaling;movement of cell or subcellular component;nitrogen compound metabolic process;defense response to bacterium;regulation of biological process;nucleic acid-templated transcription;response to external stimulus;organic substance biosynthetic process;organic substance catabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;gonad development;cellular component organization;regulation of androgen secretion;biological regulation;response to organic cyclic compound;transcription from RNA polymerase II promoter;regulation of biological quality;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;regulation of programmed cell death;development of primary male sexual characteristics;transport;regulation of biosynthetic process;regulation of cellular process;defense response;programmed cell death;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;establishment of localization;regulation of proteolysis involved in cellular protein catabolic process;male sex differentiation;endocrine process;RNA metabolic process;proteolysis involved in cellular protein catabolic process;sex differentiation;cellular nitrogen compound biosynthetic process;regulation of lipid transport;response to stimulus;proteasomal protein catabolic process;single-organism transport;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;regulation of secretion;positive regulation of cytokine production;positive regulation of multicellular organismal process;response to bacterium;RNA biosynthetic process;lipid transport;cellular macromolecule catabolic process;cell differentiation;sexual reproduction;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of secretion by cell;cellular macromolecule biosynthetic process;cell communication;positive regulation of cell communication;regulation of cell communication;single-organism process;nucleobase-containing compound metabolic process;acrosome assembly;regulation of system process;regulation of protein metabolic process;positive regulation of lipid transport;macromolecule catabolic process;gonadotropin secretion;luteinizing hormone secretion;positive regulation of secretion by cell;cellular catabolic process;proteolysis;developmental process;locomotion;positive regulation of hormone secretion;multicellular organismal process;reproductive structure development;multicellular organismal reproductive process;multicellular organism reproduction;nucleus organization;sperm motility;cellular process;cellular aromatic compound metabolic process;secretion;regulation of nucleic acid-templated transcription;regulation of hormone secretion;defense response to other organism;male gamete generation;cellular protein catabolic process;regulation of localization;macromolecule localization;regulation of endocrine process;positive regulation of testosterone secretion;cellular response to organic cyclic compound;regulation of RNA metabolic process;secretion by cell;macromolecule metabolic process;regulation of multicellular organismal process;regulation of cytokine production;localization of cell;regulation of cellular catabolic process;system development;secretory granule organization;regulation of cellular localization;reproductive system development;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell death;regulation of cell death;multicellular organism development;gamete generation;positive regulation of androgen secretion;regulation of apoptotic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;negative regulation of apoptotic process;organic substance transport;multi-organism process;negative regulation of programmed cell death;regulation of gene expression;regulation of testosterone secretion;regulation of cellular protein catabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of proteasomal protein catabolic process;apoptotic process;signal release;regulation of hormone levels;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cellular process involved in reproduction in multicellular organism;cell-cell signaling;response to chemical;regulation of metabolic process;organelle assembly;catabolic process;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;anatomical structure development;cellular metabolic process;hormone transport;single-organism organelle organization;cellular component biogenesis;regulation of proteolysis;negative regulation of cellular process;positive regulation of cellular process; 4;4;4;5;4;5;4;5;4;4;5;4;4;3;4;2;4;4;2;4;5;4;6;4;4;2;2;3;6;7;3;4;4;4;3;6;5;4;5;6;5;4;3;4;4;3;3;3;3;3;3;4;5;5;6;5;5;5;4;4;3;4;5;3;4;3;5;2;7;3;4;4;3;4;4;3;6;2;5;7;3;3;5;5;5;4;4;3;4;5;3;1;2;5;3;7;5;4;5;6;4;5;5;2;6;4;6;5;6;5;4;3;4;6;5;5;5;3;3;4;4;2;5;5;4;4;4;2;4;4;4;5;4;5;6;7;4;4;5;2;2;4;2;4;3;3;5;4;2;4;5;7;4;4;5;6;3;3;5;6;6;5;4;4;3;4;3;5;4;5;4;5;5;4;5;4;4;4;4;5;6;6;3;5;6;5;2;5;5;7;6;5;5;7;6;5;4;3;2;3;5;3;4;4;4;3;3;5;3;2;3;3;4;3;3;3;5;4;3;6;3;3; GO:0005783;GO:0016020;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575; endoplasmic reticulum;membrane;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;nucleus;cell part;cell;organelle;cellular_component; 4;2;4;4;4;3;2;3;3;3;4;3;5;3;4;4;3;5;2;2;2;1; GO:1901363;GO:0000988;GO:0003674;GO:0003676;GO:0003677;GO:0000989;GO:0097159;GO:0003712;GO:0005488; heterocyclic compound binding;transcription factor activity, protein binding;molecular_function;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;organic cyclic compound binding;transcription cofactor activity;binding; 3;2;1;4;5;3;3;4;2; K20286 IPR022091;IPR022092; TATA element modulatory factor 1 TATA binding;TATA element modulatory factor 1 DNA binding; nucleus Hs6005904 2166.0 K [K] Transcription; P05156 Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2 - [CFAI_HUMAN] 1.054 0.879 1.041 1.136 0.9 1.107 1.199089875 2.69E-07 1.262222222 1.24E-18 1.184300341 0.000281294 1.23 1.92E-07 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0044710;GO:0050727;GO:0048518;GO:0065007;GO:0019724;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0050789;GO:0002684;GO:0002682;GO:0006952;GO:0006950;GO:0016064;GO:0006956;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0002697;GO:0008150;GO:1903317;GO:0008152;GO:0032101;GO:0009611;GO:0044699;GO:0002443;GO:0051246;GO:0006508;GO:1903034;GO:0016485;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044238;GO:0002250;GO:0002253;GO:0002252; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;single-organism metabolic process;regulation of inflammatory response;positive regulation of biological process;biological regulation;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;regulation of biological process;positive regulation of immune system process;regulation of immune system process;defense response;response to stress;immunoglobulin mediated immune response;complement activation;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;regulation of immune effector process;biological_process;regulation of protein maturation;metabolic process;regulation of response to external stimulus;response to wounding;single-organism process;leukocyte mediated immunity;regulation of protein metabolic process;proteolysis;regulation of response to wounding;protein processing;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;primary metabolic process;adaptive immune response;activation of immune response;immune effector process; 4;3;3;3;5;5;3;5;2;2;6;4;4;6;6;3;4;2;5;5;2;3;3;4;3;7;4;5;3;6;5;4;7;5;2;4;1;6;2;4;4;2;4;5;5;5;6;4;5;4;4;4;3;3;5;5;4;5;3;4;3;3; GO:0031982;GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; vesicle;membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 4;2;3;2;3;4;2;3;3;1;2; GO:0004252;GO:0060089;GO:0046872;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0038024;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0004175;GO:0004872;GO:0070011;GO:0005044; serine-type endopeptidase activity;molecular transducer activity;metal ion binding;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;cargo receptor activity;peptidase activity;serine-type peptidase activity;cation binding;ion binding;endopeptidase activity;receptor activity;peptidase activity, acting on L-amino acid peptides;scavenger receptor activity; 6;2;5;4;1;2;3;2;4;4;5;4;3;6;3;5;5; K01333 map04610;map05150; Complement and coagulation cascades;Staphylococcus aureus infection; IPR023415;IPR001254;IPR003884;IPR009003;IPR018114;IPR002172;IPR001190;IPR002350;IPR017448;IPR033116;IPR001314; Low-density lipoprotein (LDL) receptor class A, conserved site;Serine proteases, trypsin domain;Factor I / membrane attack complex;Peptidase S1, PA clan;Serine proteases, trypsin family, histidine active site;Low-density lipoprotein (LDL) receptor class A repeat;SRCR domain;Kazal domain;SRCR-like domain;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular Hs4504579 1212.0 E [E] Amino acid transport and metabolism; P05155 Plasma protease C1 inhibitor OS=Homo sapiens OX=9606 GN=SERPING1 PE=1 SV=2 - [IC1_HUMAN] 1.007 0.998 0.989 0.991 1.029 1.152 1.009018036 0.193261202 0.963070943 0.171095763 0.990981964 2.37E-06 1.119533528 6.07E-15 GO:0007599;GO:0019222;GO:0048585;GO:0007596;GO:0048583;GO:0031348;GO:0003013;GO:0002455;GO:0031347;GO:0080090;GO:0044710;GO:0009611;GO:0044092;GO:0048518;GO:0048519;GO:0002526;GO:0003008;GO:0007597;GO:0019724;GO:0048584;GO:0060255;GO:0050777;GO:2000257;GO:0050776;GO:0030162;GO:0002673;GO:0030168;GO:0016192;GO:0044707;GO:0019538;GO:0045916;GO:0002376;GO:0045824;GO:0010629;GO:0045087;GO:0009892;GO:0050778;GO:0032940;GO:0002920;GO:0043170;GO:0050789;GO:0044267;GO:0051346;GO:0044260;GO:0006887;GO:0045055;GO:1900046;GO:1900047;GO:0065007;GO:0002683;GO:0010468;GO:0065009;GO:0065008;GO:0050790;GO:0008015;GO:0006810;GO:0042060;GO:0050794;GO:0006952;GO:0030193;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:0006955;GO:0010605;GO:0006958;GO:0051234;GO:0050818;GO:0050819;GO:0051336;GO:0046903;GO:0070613;GO:0051604;GO:0050896;GO:0001775;GO:0030195;GO:0006956;GO:1903317;GO:0002698;GO:0006954;GO:0032102;GO:0008152;GO:0032101;GO:0050727;GO:0030449;GO:0043086;GO:0044699;GO:0051248;GO:0016064;GO:0051241;GO:0051246;GO:0001867;GO:0006508;GO:0001869;GO:0001868;GO:1903034;GO:1903035;GO:0032502;GO:0032501;GO:0006959;GO:0050878;GO:0009987;GO:0042730;GO:0016485;GO:0032269;GO:0032268;GO:0007568;GO:0002460;GO:0002684;GO:0045861;GO:0080134;GO:2000258;GO:0031324;GO:0031323;GO:0061041;GO:0061045;GO:0002682;GO:0072376;GO:0072378;GO:0002576;GO:0002697;GO:0002443;GO:0002921;GO:0071704;GO:0010467;GO:0010466;GO:0009605;GO:1903318;GO:0045088;GO:0052547;GO:0052548;GO:0044767;GO:0002449;GO:0044765;GO:0044763;GO:0010951;GO:0010955;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0002250;GO:0002253;GO:0002252;GO:0048523; hemostasis;regulation of metabolic process;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;negative regulation of defense response;circulatory system process;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;regulation of primary metabolic process;single-organism metabolic process;response to wounding;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;acute inflammatory response;system process;blood coagulation, intrinsic pathway;B cell mediated immunity;positive regulation of response to stimulus;regulation of macromolecule metabolic process;negative regulation of immune response;regulation of protein activation cascade;regulation of immune response;regulation of proteolysis;regulation of acute inflammatory response;platelet activation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;negative regulation of complement activation;immune system process;negative regulation of innate immune response;negative regulation of gene expression;innate immune response;negative regulation of metabolic process;positive regulation of immune response;secretion by cell;regulation of humoral immune response;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;exocytosis;regulated exocytosis;regulation of hemostasis;negative regulation of hemostasis;biological regulation;negative regulation of immune system process;regulation of gene expression;regulation of molecular function;regulation of biological quality;regulation of catalytic activity;blood circulation;transport;wound healing;regulation of cellular process;defense response;regulation of blood coagulation;response to stress;coagulation;biological_process;regulation of multicellular organismal process;immune response;negative regulation of macromolecule metabolic process;complement activation, classical pathway;establishment of localization;regulation of coagulation;negative regulation of coagulation;regulation of hydrolase activity;secretion;regulation of protein processing;protein maturation;response to stimulus;cell activation;negative regulation of blood coagulation;complement activation;regulation of protein maturation;negative regulation of immune effector process;inflammatory response;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;regulation of inflammatory response;regulation of complement activation;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;immunoglobulin mediated immune response;negative regulation of multicellular organismal process;regulation of protein metabolic process;complement activation, lectin pathway;proteolysis;negative regulation of complement activation, lectin pathway;regulation of complement activation, lectin pathway;regulation of response to wounding;negative regulation of response to wounding;developmental process;multicellular organismal process;humoral immune response;regulation of body fluid levels;cellular process;fibrinolysis;protein processing;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;aging;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune system process;negative regulation of proteolysis;regulation of response to stress;negative regulation of protein activation cascade;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of wound healing;negative regulation of wound healing;regulation of immune system process;protein activation cascade;blood coagulation, fibrin clot formation;platelet degranulation;regulation of immune effector process;leukocyte mediated immunity;negative regulation of humoral immune response;organic substance metabolic process;gene expression;negative regulation of peptidase activity;response to external stimulus;negative regulation of protein maturation;regulation of innate immune response;regulation of peptidase activity;regulation of endopeptidase activity;single-organism developmental process;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;negative regulation of endopeptidase activity;negative regulation of protein processing;localization;single-organism localization;primary metabolic process;cellular metabolic process;adaptive immune response;activation of immune response;immune effector process;negative regulation of cellular process; 5;3;3;5;3;4;4;5;5;4;3;4;4;2;2;6;3;4;6;3;4;4;4;4;6;6;5;5;3;4;5;2;5;5;4;3;4;4;5;4;2;5;6;4;5;6;4;4;2;3;5;3;3;4;5;4;5;3;4;5;3;4;1;3;3;4;5;3;4;4;5;5;7;5;2;4;5;4;6;4;5;4;2;4;5;5;5;2;5;7;3;5;5;5;6;6;5;4;2;2;4;4;2;6;6;5;5;4;5;3;6;4;4;4;4;6;5;3;3;4;7;4;4;5;3;5;7;3;6;5;6;7;3;5;4;3;8;7;2;3;3;3;4;3;3;3; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0099503;GO:0034774;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043227;GO:0072562;GO:0044433;GO:0030141;GO:0012505;GO:0044446;GO:0044444;GO:0097708;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;secretory vesicle;secretory granule lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;membrane-bounded organelle;blood microparticle;cytoplasmic vesicle part;secretory granule;endomembrane system;intracellular organelle part;cytoplasmic part;intracellular vesicle;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell part;intracellular organelle;cell;intracellular;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 2;4;4;5;5;6;5;3;4;3;3;2;2;3;3;4;4;3;3;4;4;5;4;5;6;5;2;3;2;3;4;2;3;3;1;2; GO:0030414;GO:0098772;GO:0003674;GO:0061135;GO:0004857;GO:0004866;GO:0004867;GO:0030234;GO:0061134; peptidase inhibitor activity;molecular function regulator;molecular_function;endopeptidase regulator activity;enzyme inhibitor activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;enzyme regulator activity;peptidase regulator activity; 5;2;1;5;4;6;7;3;4; K04001 map04610;map05133; Complement and coagulation cascades;Pertussis; IPR023795;IPR015553;IPR000215;IPR023796; Serpin, conserved site;Plasma protease C1 inhibitor;Serpin family;Serpin domain; extracellular Hs4557379 1019.0 V [V] Defense mechanisms; P05154 Plasma serine protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA5 PE=1 SV=3 - [IPSP_HUMAN] 0.885 0.983 1.259 0.925 0.908 1.188 0.900305188 0.385965108 1.018722467 0.760129575 1.280773143 0.066920228 1.308370044 0.136479214 GO:0007599;GO:0019222;GO:0007596;GO:0061025;GO:0061024;GO:0071840;GO:0080090;GO:0010605;GO:0000003;GO:0009611;GO:0044092;GO:0048519;GO:0033036;GO:0060255;GO:0007283;GO:0030162;GO:0045026;GO:0010876;GO:0051704;GO:0044703;GO:0044702;GO:0044707;GO:0019538;GO:0009566;GO:0050789;GO:0009892;GO:0043170;GO:0044267;GO:0051346;GO:0007342;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:0050790;GO:0006810;GO:0051248;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0044802;GO:0044801;GO:0051234;GO:0051336;GO:0050896;GO:0008150;GO:0008152;GO:0006869;GO:0019953;GO:0043086;GO:0044699;GO:0051246;GO:0006508;GO:0032501;GO:0048609;GO:0050878;GO:0009987;GO:0007338;GO:0048232;GO:0032269;GO:0032268;GO:0045861;GO:0031324;GO:0031323;GO:0044237;GO:0007276;GO:0032504;GO:0071704;GO:0010466;GO:0071702;GO:0052547;GO:0052548;GO:0022414;GO:0044765;GO:0044763;GO:0022412;GO:0010951;GO:0051179;GO:1902578;GO:0044238;GO:0044260;GO:0048523; hemostasis;regulation of metabolic process;blood coagulation;membrane fusion;membrane organization;cellular component organization or biogenesis;regulation of primary metabolic process;negative regulation of macromolecule metabolic process;reproduction;response to wounding;negative regulation of molecular function;negative regulation of biological process;macromolecule localization;regulation of macromolecule metabolic process;spermatogenesis;regulation of proteolysis;plasma membrane fusion;lipid localization;multi-organism process;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;protein metabolic process;fertilization;regulation of biological process;negative regulation of metabolic process;macromolecule metabolic process;cellular protein metabolic process;negative regulation of hydrolase activity;fusion of sperm to egg plasma membrane;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;regulation of catalytic activity;transport;negative regulation of protein metabolic process;wound healing;regulation of cellular process;response to stress;coagulation;single-organism membrane organization;single-organism membrane fusion;establishment of localization;regulation of hydrolase activity;response to stimulus;biological_process;metabolic process;lipid transport;sexual reproduction;negative regulation of catalytic activity;single-organism process;regulation of protein metabolic process;proteolysis;multicellular organismal process;multicellular organismal reproductive process;regulation of body fluid levels;cellular process;single fertilization;male gamete generation;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;negative regulation of proteolysis;negative regulation of cellular metabolic process;regulation of cellular metabolic process;cellular metabolic process;gamete generation;multicellular organism reproduction;organic substance metabolic process;negative regulation of peptidase activity;organic substance transport;regulation of peptidase activity;regulation of endopeptidase activity;reproductive process;single-organism transport;single-organism cellular process;cellular process involved in reproduction in multicellular organism;negative regulation of endopeptidase activity;localization;single-organism localization;primary metabolic process;cellular macromolecule metabolic process;negative regulation of cellular process; 5;3;5;5;4;2;4;4;2;4;4;2;3;4;6;6;6;4;2;3;3;3;4;4;2;3;4;5;6;5;3;2;3;3;4;4;5;5;3;3;4;4;5;3;5;2;1;2;5;3;5;2;5;5;2;3;4;2;5;5;5;5;6;4;4;3;4;3;3;7;5;6;7;2;4;3;4;8;2;3;3;4;3; GO:0016023;GO:0016020;GO:0031988;GO:0099503;GO:0098588;GO:0043234;GO:0043230;GO:0043231;GO:0097179;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0030141;GO:0097708;GO:0012506;GO:0031982;GO:0044446;GO:0044444;GO:0012505;GO:0005886;GO:0001669;GO:0005737;GO:0031094;GO:0030667;GO:0031091;GO:0031090;GO:0031410;GO:0097223;GO:0044459;GO:0009986;GO:0030659;GO:0036030;GO:0044464;GO:0005623;GO:0005622;GO:0002080;GO:0071944;GO:0098552;GO:0036029;GO:0036028;GO:0070062;GO:0098805;GO:0036025;GO:0036024;GO:0036027;GO:0036026;GO:0097183;GO:0097182;GO:0097181;GO:0097180;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576; cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;secretory vesicle;bounding membrane of organelle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;protease inhibitor complex;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;secretory granule;intracellular vesicle;vesicle membrane;vesicle;intracellular organelle part;cytoplasmic part;endomembrane system;plasma membrane;acrosomal vesicle;cytoplasm;platelet dense tubular network;secretory granule membrane;platelet alpha granule;organelle membrane;cytoplasmic vesicle;sperm part;plasma membrane part;cell surface;cytoplasmic vesicle membrane;protein C inhibitor-plasma kallikrein complex;cell part;cell;intracellular;acrosomal membrane;cell periphery;side of membrane;protein C inhibitor-KLK3 complex;protein C inhibitor-thrombin complex;extracellular exosome;whole membrane;protein C inhibitor-TMPRSS11E complex;protein C inhibitor-TMPRSS7 complex;protein C inhibitor-PLAU complex;protein C inhibitor-PLAT complex;protein C inhibitor-coagulation factor XI complex;protein C inhibitor-coagulation factor Xa complex;protein C inhibitor-coagulation factor V complex;serine protease inhibitor complex;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region; 5;2;5;6;4;3;3;4;4;3;2;2;2;4;3;3;2;4;4;4;4;4;3;4;3;3;4;4;5;4;5;3;5;3;3;3;5;6;2;2;3;4;3;3;6;6;4;3;6;6;6;6;6;6;6;5;3;3;2;1;2; GO:0030414;GO:0032190;GO:0098772;GO:0097367;GO:0004867;GO:0003674;GO:0005488;GO:0061135;GO:0043168;GO:0043169;GO:0031406;GO:0001972;GO:0005543;GO:0019899;GO:0004857;GO:0043167;GO:0070405;GO:0002020;GO:0005501;GO:0008289;GO:0004866;GO:0033293;GO:0008201;GO:0043178;GO:0043177;GO:0005515;GO:1901681;GO:0005539;GO:0030234;GO:0061134;GO:0036094;GO:0031210;GO:0019840;GO:0050997; peptidase inhibitor activity;acrosin binding;molecular function regulator;carbohydrate derivative binding;serine-type endopeptidase inhibitor activity;molecular_function;binding;endopeptidase regulator activity;anion binding;cation binding;carboxylic acid binding;retinoic acid binding;phospholipid binding;enzyme binding;enzyme inhibitor activity;ion binding;ammonium ion binding;protease binding;retinoid binding;lipid binding;endopeptidase inhibitor activity;monocarboxylic acid binding;heparin binding;alcohol binding;organic acid binding;protein binding;sulfur compound binding;glycosaminoglycan binding;enzyme regulator activity;peptidase regulator activity;small molecule binding;phosphatidylcholine binding;isoprenoid binding;quaternary ammonium group binding; 5;5;2;3;7;1;2;5;4;4;5;6;4;4;4;3;5;5;5;3;6;6;4;4;4;3;3;4;3;4;3;4;4;3; K03913 map04610; Complement and coagulation cascades; IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; extracellular Hs21361195 837.0 V [V] Defense mechanisms; Q5T4S7 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1 - [UBR4_HUMAN] 0.77 0.825 1.893 0.765 0.752 1.114 0.933333333 0.286206283 1.017287234 0.945871102 2.294545455 0.000400234 1.481382979 0.013644768 GO:0044238;GO:0044237;GO:0044248;GO:0043170;GO:0044419;GO:0043632;GO:1901575;GO:0044265;GO:0071704;GO:0070647;GO:0042787;GO:0009057;GO:0044267;GO:0016567;GO:0044260;GO:0009987;GO:0019941;GO:0032446;GO:0006464;GO:0043412;GO:0044764;GO:0008150;GO:0030163;GO:0008152;GO:0044403;GO:0044257;GO:0006508;GO:0051704;GO:0051603;GO:0019538;GO:0036211;GO:0016032;GO:0006511;GO:0009056; primary metabolic process;cellular metabolic process;cellular catabolic process;macromolecule metabolic process;interspecies interaction between organisms;modification-dependent macromolecule catabolic process;organic substance catabolic process;cellular macromolecule catabolic process;organic substance metabolic process;protein modification by small protein conjugation or removal;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;macromolecule catabolic process;cellular protein metabolic process;protein ubiquitination;cellular macromolecule metabolic process;cellular process;modification-dependent protein catabolic process;protein modification by small protein conjugation;cellular protein modification process;macromolecule modification;multi-organism cellular process;biological_process;protein catabolic process;metabolic process;symbiosis, encompassing mutualism through parasitism;cellular protein catabolic process;proteolysis;multi-organism process;proteolysis involved in cellular protein catabolic process;protein metabolic process;protein modification process;viral process;ubiquitin-dependent protein catabolic process;catabolic process; 3;3;4;4;3;6;4;5;3;7;9;5;5;9;4;2;7;8;6;5;3;1;5;2;4;6;5;2;6;4;5;4;8;3; GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0005575;GO:0031981;GO:0005813;GO:0016021;GO:0016020;GO:0005815;GO:0005654;GO:0044430;GO:0005856;GO:0015630;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044425;GO:0005634;GO:0044422; membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;cellular_component;nuclear lumen;centrosome;integral component of membrane;membrane;microtubule organizing center;nucleoplasm;cytoskeletal part;cytoskeleton;microtubule cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;membrane part;nucleus;organelle part; 2;3;3;3;2;3;4;1;5;5;4;2;5;5;4;5;6;4;4;3;2;2;3;3;4;4;3;2;5;2; GO:0003674;GO:0005488;GO:0043167;GO:0019787;GO:0016740;GO:0046872;GO:0043169;GO:0046914;GO:0003824;GO:0004842;GO:0016874;GO:0008270; molecular_function;binding;ion binding;ubiquitin-like protein transferase activity;transferase activity;metal ion binding;cation binding;transition metal ion binding;catalytic activity;ubiquitin-protein transferase activity;ligase activity;zinc ion binding; 1;2;3;4;3;5;4;6;2;5;3;7; K10691 map05203; Viral carcinogenesis; IPR025704;IPR003126;IPR016024;IPR011989;IPR017986; E3 ubiquitin ligase, UBR4;Zinc finger, UBR-type;Armadillo-type fold;Armadillo-like helical;WD40-repeat-containing domain; plasma membrane Hs20533896 10770.0 T [T] Signal transduction mechanisms; P33908 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Homo sapiens OX=9606 GN=MAN1A1 PE=1 SV=3 - [MA1A1_HUMAN] 1.214 1.066 0.648 1.144 1.142 1.225 1.138836773 nan 1.001751313 nan 0.607879925 nan 1.07267951 nan GO:0044710;GO:0018193;GO:0019538;GO:0036508;GO:0036507;GO:1901576;GO:0044260;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0043413;GO:0006517;GO:0018196;GO:0009311;GO:0044249;GO:0034645;GO:0044699;GO:0043687;GO:0009987;GO:1904381;GO:1901137;GO:1901135;GO:0043170;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0071704;GO:0018279;GO:0044267;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0044238;GO:0005975;GO:0006491;GO:0044237; single-organism metabolic process;peptidyl-amino acid modification;protein metabolic process;protein alpha-1,2-demannosylation;protein demannosylation;organic substance biosynthetic process;cellular macromolecule metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;macromolecule glycosylation;protein deglycosylation;peptidyl-asparagine modification;oligosaccharide metabolic process;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;post-translational protein modification;cellular process;Golgi apparatus mannose trimming;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;organic substance metabolic process;protein N-linked glycosylation via asparagine;cellular protein metabolic process;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;primary metabolic process;carbohydrate metabolic process;N-glycan processing;cellular metabolic process; 3;7;4;9;8;4;4;5;5;1;2;4;6;7;8;5;4;5;2;7;2;10;5;4;4;5;6;4;5;3;6;5;5;6;3;5;3;3;4;6;3; GO:0005783;GO:0031982;GO:0016021;GO:0016020;GO:0005794;GO:0005793;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0000139;GO:0070062;GO:1903561;GO:0005575;GO:0005576; endoplasmic reticulum;vesicle;integral component of membrane;membrane;Golgi apparatus;endoplasmic reticulum-Golgi intermediate compartment;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;cell part;cell;Golgi membrane;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;4;4;2;4;5;4;3;4;3;2;2;2;3;3;3;2;4;3;3;3;4;4;3;2;2;5;4;3;1;2; GO:0046872;GO:0004553;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0004559;GO:0016798;GO:0043169;GO:0043167;GO:0005509;GO:0015924;GO:0015923;GO:0004571; metal ion binding;hydrolase activity, hydrolyzing O-glycosyl compounds;molecular_function;binding;hydrolase activity;catalytic activity;alpha-mannosidase activity;hydrolase activity, acting on glycosyl bonds;cation binding;ion binding;calcium ion binding;mannosyl-oligosaccharide mannosidase activity;mannosidase activity;mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; 5;5;1;2;3;2;7;4;4;3;6;8;6;9; K01230 map00510;map00513;map01100;map04141; N-Glycan biosynthesis;Various types of N-glycan biosynthesis;Metabolic pathways;Protein processing in endoplasmic reticulum; IPR001382; Glycoside hydrolase family 47; endoplasmic reticulum Hs20551810 1337.0 G [G] Carbohydrate transport and metabolism; P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Homo sapiens OX=9606 GN=SRD5A1 PE=1 SV=1 - [S5A1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0021510;GO:0007610;GO:0001501;GO:0060322;GO:0044281;GO:1901362;GO:1901360;GO:0009267;GO:0042445;GO:0044710;GO:0044711;GO:0048869;GO:0042448;GO:0070848;GO:0045137;GO:0048511;GO:0048512;GO:0048513;GO:0021854;GO:0071872;GO:0034698;GO:0048806;GO:1901160;GO:0031960;GO:0035270;GO:0044702;GO:0043434;GO:0010033;GO:0046483;GO:0031668;GO:0065008;GO:1901564;GO:0044707;GO:0044249;GO:0044708;GO:0010243;GO:0071320;GO:0031667;GO:0046683;GO:0007154;GO:0031669;GO:0033554;GO:0071407;GO:0060416;GO:0021537;GO:0021536;GO:0061008;GO:0042493;GO:0042747;GO:0006807;GO:0042428;GO:0071867;GO:0071868;GO:0071869;GO:0006629;GO:0009605;GO:1901576;GO:0097164;GO:0008406;GO:0065007;GO:0007417;GO:0009719;GO:0007623;GO:0007622;GO:0046546;GO:0051716;GO:0006950;GO:0008150;GO:0008152;GO:0071870;GO:0046660;GO:0042430;GO:0071375;GO:0007548;GO:0007420;GO:0021543;GO:0050896;GO:1901699;GO:0006694;GO:0097305;GO:0022410;GO:0071871;GO:0050802;GO:0030154;GO:0021766;GO:0034641;GO:0070887;GO:0021761;GO:0014074;GO:0000003;GO:0044699;GO:0030540;GO:0046661;GO:0021794;GO:0032502;GO:0032501;GO:0048608;GO:1901701;GO:0006721;GO:0006720;GO:0009987;GO:0006725;GO:0071394;GO:0060992;GO:0032870;GO:0008209;GO:0016101;GO:0018958;GO:0044255;GO:0008207;GO:0008202;GO:0071363;GO:0009725;GO:0042745;GO:0051591;GO:0014070;GO:0048731;GO:0048732;GO:1901698;GO:0048545;GO:0071495;GO:0009991;GO:0051384;GO:0061458;GO:0071383;GO:0071392;GO:0071385;GO:0071384;GO:0060348;GO:0071496;GO:0001889;GO:0042594;GO:0021983;GO:0032869;GO:0032868;GO:0007275;GO:0033574;GO:0032355;GO:0032354;GO:0033993;GO:0071417;GO:0009636;GO:0021987;GO:0071704;GO:0071310;GO:0097306;GO:0030900;GO:0007530;GO:0014823;GO:0006702;GO:0071391;GO:0071396;GO:0010817;GO:0044767;GO:0022414;GO:0009058;GO:0042446;GO:0044763;GO:0030431;GO:0043627;GO:0042221;GO:0034754;GO:0008584;GO:0008610;GO:1901700;GO:0044238;GO:0071549;GO:0071548;GO:0042180;GO:0007399;GO:0003006;GO:0048856;GO:0030539;GO:0044237;GO:1901654;GO:1901655;GO:1901652;GO:1901653;GO:0014850;GO:1901615;GO:0001655; spinal cord development;behavior;skeletal system development;head development;small molecule metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to starvation;hormone metabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular developmental process;progesterone metabolic process;response to growth factor;development of primary sexual characteristics;rhythmic process;circadian behavior;animal organ development;hypothalamus development;cellular response to epinephrine stimulus;response to gonadotropin;genitalia development;primary amino compound metabolic process;response to corticosteroid;endocrine system development;single organism reproductive process;response to peptide hormone;response to organic substance;heterocycle metabolic process;cellular response to extracellular stimulus;regulation of biological quality;organonitrogen compound metabolic process;single-multicellular organism process;cellular biosynthetic process;single-organism behavior;response to organonitrogen compound;cellular response to cAMP;response to nutrient levels;response to organophosphorus;cell communication;cellular response to nutrient levels;cellular response to stress;cellular response to organic cyclic compound;response to growth hormone;telencephalon development;diencephalon development;hepaticobiliary system development;response to drug;circadian sleep/wake cycle, REM sleep;nitrogen compound metabolic process;serotonin metabolic process;response to monoamine;cellular response to monoamine stimulus;response to catecholamine;lipid metabolic process;response to external stimulus;organic substance biosynthetic process;ammonium ion metabolic process;gonad development;biological regulation;central nervous system development;response to endogenous stimulus;circadian rhythm;rhythmic behavior;development of primary male sexual characteristics;cellular response to stimulus;response to stress;biological_process;metabolic process;cellular response to catecholamine stimulus;female sex differentiation;indole-containing compound metabolic process;cellular response to peptide hormone stimulus;sex differentiation;brain development;pallium development;response to stimulus;cellular response to nitrogen compound;steroid biosynthetic process;response to alcohol;circadian sleep/wake cycle process;response to epinephrine;circadian sleep/wake cycle, sleep;cell differentiation;hippocampus development;cellular nitrogen compound metabolic process;cellular response to chemical stimulus;limbic system development;response to purine-containing compound;reproduction;single-organism process;female genitalia development;male sex differentiation;thalamus development;developmental process;multicellular organismal process;reproductive structure development;cellular response to oxygen-containing compound;terpenoid metabolic process;isoprenoid metabolic process;cellular process;cellular aromatic compound metabolic process;cellular response to testosterone stimulus;response to fungicide;cellular response to hormone stimulus;androgen metabolic process;diterpenoid metabolic process;phenol-containing compound metabolic process;cellular lipid metabolic process;C21-steroid hormone metabolic process;steroid metabolic process;cellular response to growth factor stimulus;response to hormone;circadian sleep/wake cycle;response to cAMP;response to organic cyclic compound;system development;gland development;response to nitrogen compound;response to steroid hormone;cellular response to endogenous stimulus;response to extracellular stimulus;response to glucocorticoid;reproductive system development;cellular response to steroid hormone stimulus;cellular response to estradiol stimulus;cellular response to glucocorticoid stimulus;cellular response to corticosteroid stimulus;bone development;cellular response to external stimulus;liver development;response to starvation;pituitary gland development;cellular response to insulin stimulus;response to insulin;multicellular organism development;response to testosterone;response to estradiol;response to follicle-stimulating hormone;response to lipid;cellular response to organonitrogen compound;response to toxic substance;cerebral cortex development;organic substance metabolic process;cellular response to organic substance;cellular response to alcohol;forebrain development;sex determination;response to activity;androgen biosynthetic process;cellular response to estrogen stimulus;cellular response to lipid;regulation of hormone levels;single-organism developmental process;reproductive process;biosynthetic process;hormone biosynthetic process;single-organism cellular process;sleep;response to estrogen;response to chemical;cellular hormone metabolic process;male gonad development;lipid biosynthetic process;response to oxygen-containing compound;primary metabolic process;cellular response to dexamethasone stimulus;response to dexamethasone;cellular ketone metabolic process;nervous system development;developmental process involved in reproduction;anatomical structure development;male genitalia development;cellular metabolic process;response to ketone;cellular response to ketone;response to peptide;cellular response to peptide;response to muscle activity;organic hydroxy compound metabolic process;urogenital system development; 5;2;5;4;4;5;4;5;3;3;4;4;5;5;4;2;4;4;4;7;5;4;5;6;5;3;5;4;4;4;3;4;3;4;3;4;6;5;5;4;5;4;6;6;4;4;5;4;5;3;5;5;6;5;4;3;4;4;4;2;5;3;3;3;5;3;3;1;2;6;5;5;6;4;4;4;2;5;6;5;5;6;4;5;4;4;4;5;5;2;2;5;5;4;2;2;4;5;6;5;2;4;7;5;5;4;7;5;4;4;5;6;4;5;5;5;4;4;4;5;4;4;7;5;6;7;8;7;4;4;5;4;5;7;6;4;6;6;6;5;5;4;4;3;5;6;4;4;3;5;7;6;4;3;2;3;4;3;4;6;3;4;5;5;4;3;7;6;4;5;3;3;5;3;5;6;5;6;4;4;5; GO:0005783;GO:0005789;GO:0097458;GO:0043209;GO:0016020;GO:0098588;GO:0044297;GO:0036477;GO:0042995;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044432;GO:0031224;GO:0048471;GO:0043025;GO:0012505;GO:0044446;GO:0044444;GO:0016021;GO:0042175;GO:0005737;GO:0031090;GO:0043005;GO:0044464;GO:0005623;GO:0005622;GO:0070852;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;neuron part;myelin sheath;membrane;bounding membrane of organelle;cell body;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;endoplasmic reticulum part;intrinsic component of membrane;perinuclear region of cytoplasm;neuronal cell body;endomembrane system;intracellular organelle part;cytoplasmic part;integral component of membrane;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasm;organelle membrane;neuron projection;cell part;cell;intracellular;cell body fiber;cellular_component; 4;3;3;3;2;4;3;4;3;4;3;2;2;3;3;2;4;3;5;4;3;3;4;4;3;4;3;4;2;2;3;5;1; GO:0047751;GO:1901363;GO:0016628;GO:0016627;GO:0000166;GO:0035671;GO:0003674;GO:0005488;GO:1901265;GO:0033765;GO:0003824;GO:0036094;GO:0097159;GO:0043167;GO:0016491;GO:0009055;GO:0048037;GO:0033218;GO:0016229;GO:0050662;GO:0050661;GO:0003865;GO:0043168;GO:0070402; cholestenone 5-alpha-reductase activity;heterocyclic compound binding;oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;oxidoreductase activity, acting on the CH-CH group of donors;nucleotide binding;enone reductase activity;molecular_function;binding;nucleoside phosphate binding;steroid dehydrogenase activity, acting on the CH-CH group of donors;catalytic activity;small molecule binding;organic cyclic compound binding;ion binding;oxidoreductase activity;electron carrier activity;cofactor binding;amide binding;steroid dehydrogenase activity;coenzyme binding;NADP binding;3-oxo-5-alpha-steroid 4-dehydrogenase activity;anion binding;NADPH binding; 7;3;5;4;4;6;1;2;4;5;2;3;3;3;3;2;3;3;4;4;5;6;4;5; K12343 map00140; Steroid hormone biosynthesis; IPR001104;IPR016636; 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal;3-oxo-5-alpha-steroid 4-dehydrogenase; extracellular Hs4507201 537.0 I [I] Lipid transport and metabolism; O43264 Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3 - [ZW10_HUMAN] 0.993 1.163 0.789 0.956 1.058 1.804 0.853826311 0.247716698 0.903591682 0.581768256 0.678417885 0.072760712 1.70510397 0.301844923 GO:0008104;GO:0032434;GO:0032435;GO:0051985;GO:0007163;GO:0007165;GO:0010965;GO:0051656;GO:0071840;GO:0051716;GO:0045786;GO:0000003;GO:0070727;GO:0010256;GO:0033043;GO:0007080;GO:1901799;GO:0065007;GO:0033036;GO:0010605;GO:0060255;GO:0051294;GO:0032269;GO:0051293;GO:0045184;GO:0032268;GO:0030162;GO:0030163;GO:0051302;GO:1902099;GO:0016192;GO:0044700;GO:0044702;GO:0019538;GO:0010639;GO:0051783;GO:0051782;GO:0042177;GO:0051784;GO:0044784;GO:0045841;GO:0009894;GO:0022607;GO:0009892;GO:0007067;GO:0043170;GO:0031577;GO:0007346;GO:0044265;GO:0006888;GO:0044260;GO:1903363;GO:0016043;GO:0065003;GO:0007049;GO:0071459;GO:0044267;GO:1901988;GO:0071174;GO:0006461;GO:0071173;GO:0006810;GO:0051248;GO:0050794;GO:1901987;GO:0008150;GO:0008152;GO:0007059;GO:0051234;GO:0051603;GO:0000132;GO:0046907;GO:0050896;GO:0010498;GO:0006511;GO:0007094;GO:1903051;GO:2001251;GO:0033044;GO:0033045;GO:0033046;GO:0033047;GO:0009057;GO:0070271;GO:0051246;GO:0033048;GO:0051129;GO:0051128;GO:0044248;GO:0042176;GO:0009895;GO:0023052;GO:1901990;GO:0030010;GO:0044699;GO:0007126;GO:0051321;GO:1901991;GO:0043161;GO:0000280;GO:1902578;GO:0006508;GO:0010458;GO:0031330;GO:1903050;GO:0009987;GO:0019941;GO:0007017;GO:0048519;GO:0051310;GO:0007010;GO:0051983;GO:0007030;GO:0007088;GO:0000819;GO:0045839;GO:0098813;GO:0044772;GO:0030071;GO:0031329;GO:0033365;GO:0000226;GO:0045861;GO:2000816;GO:0034501;GO:0034502;GO:0043933;GO:0051653;GO:0031324;GO:0031323;GO:1903047;GO:1903046;GO:0044770;GO:0044257;GO:0010948;GO:0022402;GO:0051306;GO:0043632;GO:0051304;GO:0051303;GO:0035556;GO:0051301;GO:0071822;GO:0010564;GO:0050789;GO:0071704;GO:0044085;GO:0071702;GO:0045930;GO:0000278;GO:1903362;GO:0048193;GO:0061136;GO:0034613;GO:0080090;GO:1901575;GO:0022414;GO:0044765;GO:0040001;GO:0044763;GO:0051649;GO:0007154;GO:0019222;GO:0007264;GO:0009056;GO:0051179;GO:0051640;GO:0051641;GO:0006996;GO:0044238;GO:0000070;GO:0051276;GO:0000075;GO:0051726;GO:0044237;GO:1902589;GO:0050000;GO:0048285;GO:1902100;GO:0015031;GO:1902582;GO:0007096;GO:1902580;GO:0007091;GO:0048523;GO:0007093; protein localization;regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of chromosome segregation;establishment or maintenance of cell polarity;signal transduction;regulation of mitotic sister chromatid separation;establishment of organelle localization;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of cell cycle;reproduction;cellular macromolecule localization;endomembrane system organization;regulation of organelle organization;mitotic metaphase plate congression;negative regulation of proteasomal protein catabolic process;biological regulation;macromolecule localization;negative regulation of macromolecule metabolic process;regulation of macromolecule metabolic process;establishment of spindle orientation;negative regulation of cellular protein metabolic process;establishment of spindle localization;establishment of protein localization;regulation of cellular protein metabolic process;regulation of proteolysis;protein catabolic process;regulation of cell division;regulation of metaphase/anaphase transition of cell cycle;vesicle-mediated transport;single organism signaling;single organism reproductive process;protein metabolic process;negative regulation of organelle organization;regulation of nuclear division;negative regulation of cell division;negative regulation of protein catabolic process;negative regulation of nuclear division;metaphase/anaphase transition of cell cycle;negative regulation of mitotic metaphase/anaphase transition;regulation of catabolic process;cellular component assembly;negative regulation of metabolic process;mitotic nuclear division;macromolecule metabolic process;spindle checkpoint;regulation of mitotic cell cycle;cellular macromolecule catabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;negative regulation of cellular protein catabolic process;cellular component organization;macromolecular complex assembly;cell cycle;protein localization to chromosome, centromeric region;cellular protein metabolic process;negative regulation of cell cycle phase transition;mitotic spindle checkpoint;protein complex assembly;spindle assembly checkpoint;transport;negative regulation of protein metabolic process;regulation of cellular process;regulation of cell cycle phase transition;biological_process;metabolic process;chromosome segregation;establishment of localization;proteolysis involved in cellular protein catabolic process;establishment of mitotic spindle orientation;intracellular transport;response to stimulus;proteasomal protein catabolic process;ubiquitin-dependent protein catabolic process;mitotic spindle assembly checkpoint;negative regulation of proteolysis involved in cellular protein catabolic process;negative regulation of chromosome organization;regulation of chromosome organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;macromolecule catabolic process;protein complex biogenesis;regulation of protein metabolic process;negative regulation of mitotic sister chromatid segregation;negative regulation of cellular component organization;regulation of cellular component organization;cellular catabolic process;regulation of protein catabolic process;negative regulation of catabolic process;signaling;regulation of mitotic cell cycle phase transition;establishment of cell polarity;single-organism process;meiotic nuclear division;meiotic cell cycle;negative regulation of mitotic cell cycle phase transition;proteasome-mediated ubiquitin-dependent protein catabolic process;nuclear division;single-organism localization;proteolysis;exit from mitosis;negative regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;microtubule-based process;negative regulation of biological process;metaphase plate congression;cytoskeleton organization;regulation of chromosome segregation;Golgi organization;regulation of mitotic nuclear division;sister chromatid segregation;negative regulation of mitotic nuclear division;nuclear chromosome segregation;mitotic cell cycle phase transition;regulation of mitotic metaphase/anaphase transition;regulation of cellular catabolic process;protein localization to organelle;microtubule cytoskeleton organization;negative regulation of proteolysis;negative regulation of mitotic sister chromatid separation;protein localization to kinetochore;protein localization to chromosome;macromolecular complex subunit organization;spindle localization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;meiotic cell cycle process;cell cycle phase transition;cellular protein catabolic process;negative regulation of cell cycle process;cell cycle process;mitotic sister chromatid separation;modification-dependent macromolecule catabolic process;chromosome separation;establishment of chromosome localization;intracellular signal transduction;cell division;protein complex subunit organization;regulation of cell cycle process;regulation of biological process;organic substance metabolic process;cellular component biogenesis;organic substance transport;negative regulation of mitotic cell cycle;mitotic cell cycle;regulation of cellular protein catabolic process;Golgi vesicle transport;regulation of proteasomal protein catabolic process;cellular protein localization;regulation of primary metabolic process;organic substance catabolic process;reproductive process;single-organism transport;establishment of mitotic spindle localization;single-organism cellular process;establishment of localization in cell;cell communication;regulation of metabolic process;small GTPase mediated signal transduction;catabolic process;localization;organelle localization;cellular localization;organelle organization;primary metabolic process;mitotic sister chromatid segregation;chromosome organization;cell cycle checkpoint;regulation of cell cycle;cellular metabolic process;single-organism organelle organization;chromosome localization;organelle fission;negative regulation of metaphase/anaphase transition of cell cycle;protein transport;single-organism intracellular transport;regulation of exit from mitosis;single-organism cellular localization;metaphase/anaphase transition of mitotic cell cycle;negative regulation of cellular process;mitotic cell cycle checkpoint; 4;8;8;4;4;4;7;4;2;3;4;2;4;4;5;5;7;2;3;4;4;6;5;5;4;5;6;5;4;6;5;3;3;4;5;5;4;5;5;6;7;4;4;3;5;4;6;5;5;7;4;6;3;5;4;8;5;6;6;5;7;4;5;3;6;1;2;4;3;6;6;5;2;6;8;6;7;6;6;5;5;6;5;4;5;6;4;4;4;5;4;2;6;5;2;4;3;6;7;6;3;5;6;5;7;2;7;4;2;6;5;4;5;6;5;6;5;6;7;5;6;5;6;7;9;7;4;5;4;4;5;4;5;6;5;4;6;6;5;5;5;4;5;5;2;3;3;5;5;5;6;6;7;5;4;4;2;4;6;3;4;4;3;6;3;2;4;3;4;3;6;5;5;4;3;4;5;5;7;5;5;7;4;6;3;6; GO:0099512;GO:0005783;GO:0005789;GO:0070939;GO:0099513;GO:0016020;GO:0000922;GO:0000776;GO:0098588;GO:0000793;GO:0043234;GO:0043231;GO:0043232;GO:0005829;GO:0005828;GO:0044424;GO:0044425;GO:0044427;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0044432;GO:0044430;GO:1990423;GO:0005876;GO:0012505;GO:0098687;GO:0000779;GO:0044446;GO:0044444;GO:0042175;GO:0005874;GO:0005737;GO:0031090;GO:0005634;GO:0000775;GO:0000777;GO:0044464;GO:0005623;GO:0005622;GO:0005819;GO:0005694;GO:0015630;GO:0032991;GO:0005575; supramolecular fiber;endoplasmic reticulum;endoplasmic reticulum membrane;Dsl1p complex;polymeric cytoskeletal fiber;membrane;spindle pole;kinetochore;bounding membrane of organelle;condensed chromosome;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;kinetochore microtubule;intracellular part;membrane part;chromosomal part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;endoplasmic reticulum part;cytoskeletal part;RZZ complex;spindle microtubule;endomembrane system;chromosomal region;condensed chromosome, centromeric region;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;microtubule;cytoplasm;organelle membrane;nucleus;chromosome, centromeric region;condensed chromosome kinetochore;cell part;cell;intracellular;spindle;chromosome;microtubule cytoskeleton;macromolecular complex;cellular_component; 2;4;3;4;3;2;5;4;4;6;3;4;4;5;6;3;2;4;2;3;3;3;2;5;4;4;4;5;3;5;7;3;4;3;4;4;3;5;6;5;2;2;3;5;5;6;2;1; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0019237;GO:0097159;GO:0043565;GO:1990837;GO:0003690; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;centromeric DNA binding;organic cyclic compound binding;sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding; 3;1;2;4;5;8;3;6;7;6; K11578 IPR009361; RZZ complex, subunit Zw10; cytosol Hs4759344 1608.0 D [D] Cell cycle control, cell division, chromosome partitioning; P14780 Matrix metalloproteinase-9 OS=Homo sapiens OX=9606 GN=MMP9 PE=1 SV=3 - [MMP9_HUMAN] 1.283 0.998 0.978 0.977 1.111 0.383 1.285571142 nan 0.879387939 nan 0.97995992 nan 0.344734473 nan GO:2001234;GO:2001235;GO:0019220;GO:0080090;GO:0019222;GO:2001233;GO:0030225;GO:0051049;GO:0001667;GO:0048584;GO:0048583;GO:0001501;GO:0001503;GO:0097193;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0034766;GO:0032989;GO:0007005;GO:0034763;GO:0044712;GO:2001267;GO:0051716;GO:0010605;GO:0042330;GO:0009966;GO:0048869;GO:0044259;GO:0007369;GO:0055085;GO:0048513;GO:0044093;GO:0044092;GO:0048518;GO:0048519;GO:0048585;GO:0042325;GO:0006935;GO:0051051;GO:0051704;GO:0060255;GO:0048468;GO:0032269;GO:0042221;GO:0007173;GO:0097485;GO:0010631;GO:0010634;GO:0044700;GO:0044703;GO:0044702;GO:0009605;GO:0044707;GO:0048870;GO:0019538;GO:0044706;GO:0010638;GO:0032410;GO:0002376;GO:0030198;GO:0044710;GO:0048598;GO:0009892;GO:0010466;GO:0032412;GO:0032413;GO:0032963;GO:0051101;GO:0006468;GO:0006928;GO:0034762;GO:0051674;GO:0043393;GO:0031175;GO:0043388;GO:0061564;GO:1901184;GO:0042981;GO:0050789;GO:0006793;GO:0044267;GO:0032092;GO:0009653;GO:0000902;GO:0016043;GO:0098655;GO:0065007;GO:0071840;GO:0065009;GO:0016477;GO:0048646;GO:0051130;GO:0006810;GO:0090199;GO:0006812;GO:0006811;GO:0050790;GO:0042327;GO:0009888;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0006464;GO:0051239;GO:0048731;GO:1902532;GO:0044243;GO:0048013;GO:0045937;GO:0035987;GO:0045861;GO:0002521;GO:0002520;GO:0051336;GO:0051174;GO:0034765;GO:0009968;GO:0012501;GO:0022898;GO:0050896;GO:0031401;GO:0030574;GO:0043154;GO:0048812;GO:2000145;GO:2000147;GO:0009967;GO:0022411;GO:0010562;GO:0007492;GO:0008152;GO:0033043;GO:0016310;GO:0030154;GO:0090200;GO:0051128;GO:0023056;GO:0023057;GO:0023052;GO:0038127;GO:0035556;GO:0023051;GO:0007411;GO:0010647;GO:0010646;GO:0043086;GO:0044699;GO:0009893;GO:0051248;GO:1902531;GO:0001706;GO:0034220;GO:0001704;GO:0051240;GO:0051246;GO:0051247;GO:0000003;GO:0032409;GO:0045742;GO:0031399;GO:0006508;GO:0022617;GO:0010632;GO:2001242;GO:0032502;GO:0006996;GO:0090130;GO:0032501;GO:0044238;GO:0031323;GO:0009987;GO:0044260;GO:0043281;GO:0040012;GO:0007409;GO:0032879;GO:0090132;GO:0048858;GO:0008637;GO:0032268;GO:0040017;GO:0007565;GO:0051099;GO:0051098;GO:1904062;GO:0007566;GO:0043170;GO:1900122;GO:1900120;GO:2001243;GO:0030099;GO:0030097;GO:0009790;GO:0032270;GO:0030030;GO:0031325;GO:0031324;GO:0097190;GO:0010604;GO:0042058;GO:1901186;GO:0050900;GO:0010821;GO:0044237;GO:0010822;GO:0010942;GO:0051234;GO:0008219;GO:0010941;GO:0007275;GO:0043269;GO:0051547;GO:0051546;GO:1904063;GO:2000116;GO:0051549;GO:0006796;GO:0002573;GO:0043065;GO:0071704;GO:0043067;GO:0043062;GO:0048534;GO:0043069;GO:0043068;GO:2001268;GO:0048666;GO:0048667;GO:0030335;GO:0030334;GO:2001258;GO:0030182;GO:0052547;GO:0052548;GO:0006915;GO:0043066;GO:0060548;GO:0044767;GO:0022414;GO:0044765;GO:0000904;GO:0044763;GO:2001257;GO:0010951;GO:0007154;GO:0022008;GO:0009056;GO:0051179;GO:1902578;GO:0051346;GO:0040011;GO:0051272;GO:0048699;GO:0051270;GO:0032990;GO:0007399;GO:0043271;GO:0048856;GO:0001836;GO:0044236;GO:0010648;GO:2000117;GO:0030162;GO:0001932;GO:0001934;GO:0048523;GO:0048522; negative regulation of apoptotic signaling pathway;positive regulation of apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;macrophage differentiation;regulation of transport;ameboidal-type cell migration;positive regulation of response to stimulus;regulation of response to stimulus;skeletal system development;ossification;intrinsic apoptotic signaling pathway;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of ion transmembrane transport;cellular component morphogenesis;mitochondrion organization;negative regulation of transmembrane transport;single-organism catabolic process;regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;taxis;regulation of signal transduction;cellular developmental process;multicellular organismal macromolecule metabolic process;gastrulation;transmembrane transport;animal organ development;positive regulation of molecular function;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;negative regulation of response to stimulus;regulation of phosphorylation;chemotaxis;negative regulation of transport;multi-organism process;regulation of macromolecule metabolic process;cell development;negative regulation of cellular protein metabolic process;response to chemical;epidermal growth factor receptor signaling pathway;neuron projection guidance;epithelial cell migration;positive regulation of epithelial cell migration;single organism signaling;multi-organism reproductive process;single organism reproductive process;response to external stimulus;single-multicellular organism process;cell motility;protein metabolic process;multi-multicellular organism process;positive regulation of organelle organization;negative regulation of transporter activity;immune system process;extracellular matrix organization;single-organism metabolic process;embryonic morphogenesis;negative regulation of metabolic process;negative regulation of peptidase activity;regulation of ion transmembrane transporter activity;negative regulation of ion transmembrane transporter activity;collagen metabolic process;regulation of DNA binding;protein phosphorylation;movement of cell or subcellular component;regulation of transmembrane transport;localization of cell;regulation of protein binding;neuron projection development;positive regulation of DNA binding;axon development;regulation of ERBB signaling pathway;regulation of apoptotic process;regulation of biological process;phosphorus metabolic process;cellular protein metabolic process;positive regulation of protein binding;anatomical structure morphogenesis;cell morphogenesis;cellular component organization;cation transmembrane transport;biological regulation;cellular component organization or biogenesis;regulation of molecular function;cell migration;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;transport;regulation of release of cytochrome c from mitochondria;cation transport;ion transport;regulation of catalytic activity;positive regulation of phosphorylation;tissue development;regulation of cellular process;macromolecule modification;protein modification process;biological_process;cellular protein modification process;regulation of multicellular organismal process;system development;negative regulation of intracellular signal transduction;multicellular organism catabolic process;ephrin receptor signaling pathway;positive regulation of phosphate metabolic process;endodermal cell differentiation;negative regulation of proteolysis;leukocyte differentiation;immune system development;regulation of hydrolase activity;regulation of phosphorus metabolic process;regulation of ion transmembrane transport;negative regulation of signal transduction;programmed cell death;regulation of transmembrane transporter activity;response to stimulus;positive regulation of protein modification process;collagen catabolic process;negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;neuron projection morphogenesis;regulation of cell motility;positive regulation of cell motility;positive regulation of signal transduction;cellular component disassembly;positive regulation of phosphorus metabolic process;endoderm development;metabolic process;regulation of organelle organization;phosphorylation;cell differentiation;positive regulation of release of cytochrome c from mitochondria;regulation of cellular component organization;positive regulation of signaling;negative regulation of signaling;signaling;ERBB signaling pathway;intracellular signal transduction;regulation of signaling;axon guidance;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;single-organism process;positive regulation of metabolic process;negative regulation of protein metabolic process;regulation of intracellular signal transduction;endoderm formation;ion transmembrane transport;formation of primary germ layer;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;reproduction;regulation of transporter activity;positive regulation of epidermal growth factor receptor signaling pathway;regulation of protein modification process;proteolysis;extracellular matrix disassembly;regulation of epithelial cell migration;regulation of intrinsic apoptotic signaling pathway;developmental process;organelle organization;tissue migration;multicellular organismal process;primary metabolic process;regulation of cellular metabolic process;cellular process;cellular macromolecule metabolic process;regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of locomotion;axonogenesis;regulation of localization;epithelium migration;cell projection morphogenesis;apoptotic mitochondrial changes;regulation of cellular protein metabolic process;positive regulation of locomotion;female pregnancy;positive regulation of binding;regulation of binding;regulation of cation transmembrane transport;embryo implantation;macromolecule metabolic process;positive regulation of receptor binding;regulation of receptor binding;negative regulation of intrinsic apoptotic signaling pathway;myeloid cell differentiation;hemopoiesis;embryo development;positive regulation of cellular protein metabolic process;cell projection organization;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;apoptotic signaling pathway;positive regulation of macromolecule metabolic process;regulation of epidermal growth factor receptor signaling pathway;positive regulation of ERBB signaling pathway;leukocyte migration;regulation of mitochondrion organization;cellular metabolic process;positive regulation of mitochondrion organization;positive regulation of cell death;establishment of localization;cell death;regulation of cell death;multicellular organism development;regulation of ion transport;regulation of keratinocyte migration;keratinocyte migration;negative regulation of cation transmembrane transport;regulation of cysteine-type endopeptidase activity;positive regulation of keratinocyte migration;phosphate-containing compound metabolic process;myeloid leukocyte differentiation;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;extracellular structure organization;hematopoietic or lymphoid organ development;negative regulation of programmed cell death;positive regulation of programmed cell death;negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;neuron development;cell morphogenesis involved in neuron differentiation;positive regulation of cell migration;regulation of cell migration;negative regulation of cation channel activity;neuron differentiation;regulation of peptidase activity;regulation of endopeptidase activity;apoptotic process;negative regulation of apoptotic process;negative regulation of cell death;single-organism developmental process;reproductive process;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;regulation of cation channel activity;negative regulation of endopeptidase activity;cell communication;neurogenesis;catabolic process;localization;single-organism localization;negative regulation of hydrolase activity;locomotion;positive regulation of cellular component movement;generation of neurons;regulation of cellular component movement;cell part morphogenesis;nervous system development;negative regulation of ion transport;anatomical structure development;release of cytochrome c from mitochondria;multicellular organism metabolic process;negative regulation of cell communication;negative regulation of cysteine-type endopeptidase activity;regulation of proteolysis;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 5;5;6;4;3;5;8;4;5;3;3;5;4;6;4;5;6;7;5;4;5;4;4;6;3;4;3;4;4;5;5;4;4;4;4;2;2;3;7;4;3;2;4;4;5;3;9;5;6;4;3;3;3;3;3;3;4;3;5;4;2;5;3;4;3;7;6;5;6;5;7;4;4;3;5;5;6;6;5;6;2;4;5;6;3;5;3;6;2;2;3;4;3;4;4;6;6;5;4;7;4;3;5;5;1;6;3;4;5;5;8;6;6;6;6;3;5;5;5;4;5;5;2;6;5;7;6;4;4;4;4;5;5;2;5;6;5;6;4;3;3;2;8;5;3;6;4;4;5;2;3;5;5;5;5;4;3;5;5;2;4;6;6;5;5;4;6;2;4;4;2;3;4;2;4;7;3;7;3;5;5;6;5;3;4;5;4;6;4;4;7;6;6;6;5;5;5;4;4;4;5;4;6;5;3;6;3;6;4;3;4;4;4;5;5;7;6;8;5;5;7;6;3;5;4;4;5;5;6;5;6;5;5;6;6;6;7;6;6;4;3;2;4;5;3;7;8;4;6;3;2;3;6;2;4;7;4;5;5;4;3;6;4;4;9;6;7;7;3;3; GO:0031982;GO:0043230;GO:0044421;GO:0031012;GO:0005578;GO:0005615;GO:0070062;GO:0043227;GO:0005576;GO:1903561;GO:0005575;GO:0043226; vesicle;extracellular organelle;extracellular region part;extracellular matrix;proteinaceous extracellular matrix;extracellular space;extracellular exosome;membrane-bounded organelle;extracellular region;extracellular vesicle;cellular_component;organelle; 4;3;2;2;3;3;4;3;2;3;1;2; GO:0046872;GO:0044877;GO:0004222;GO:0008270;GO:0003674;GO:0005488;GO:0046914;GO:0016787;GO:0003824;GO:0043169;GO:0043167;GO:0032403;GO:0042802;GO:0005515;GO:0008233;GO:0005518;GO:0004175;GO:0008237;GO:0070011; metal ion binding;macromolecular complex binding;metalloendopeptidase activity;zinc ion binding;molecular_function;binding;transition metal ion binding;hydrolase activity;catalytic activity;cation binding;ion binding;protein complex binding;identical protein binding;protein binding;peptidase activity;collagen binding;endopeptidase activity;metallopeptidase activity;peptidase activity, acting on L-amino acid peptides; 5;3;7;7;1;2;6;3;2;4;3;4;4;3;4;5;6;6;5; K01403 map04668;map04670;map04915;map05161;map05200;map05202;map05205;map05206;map05219; TNF signaling pathway;Leukocyte transendothelial migration;Estrogen signaling pathway;Hepatitis B;Pathways in cancer;Transcriptional misregulation in cancer;Proteoglycans in cancer;MicroRNAs in cancer;Bladder cancer; IPR018487;IPR018486;IPR000585;IPR033739;IPR021190;IPR001818;IPR002477;IPR024079;IPR006026;IPR000562;IPR013806;IPR021158;IPR028688; Hemopexin-like repeats;Hemopexin, conserved site;Hemopexin-like domain;Peptidase M10A, catalytic domain;Peptidase M10A;Peptidase M10, metallopeptidase;Peptidoglycan binding-like;Metallopeptidase, catalytic domain;Peptidase, metallopeptidase;Fibronectin, type II, collagen-binding;Kringle-like fold;Peptidase M10A, cysteine switch, zinc binding site;Matrix metalloproteinase-9; extracellular Hs4826836 1448.0 OW [O] Posttranslational modification, protein turnover, chaperones;[W] Extracellular structures; P46939 Utrophin OS=Homo sapiens OX=9606 GN=UTRN PE=1 SV=2 - [UTRO_HUMAN] 1.349 0.94 0.667 1.166 1.068 1.347 1.435106383 0.320993713 1.0917603 0.696285283 0.709574468 0.603358996 1.261235955 nan GO:0051049;GO:0003012;GO:0034765;GO:0034762;GO:0007517;GO:0045785;GO:0071840;GO:0048513;GO:0048518;GO:0098662;GO:1902305;GO:0006936;GO:0098660;GO:0007528;GO:0050794;GO:0003008;GO:0007160;GO:0044707;GO:0032412;GO:1904062;GO:0050789;GO:0016043;GO:0065007;GO:2000649;GO:0065009;GO:0006812;GO:0006811;GO:0006810;GO:0006814;GO:0008150;GO:0051234;GO:0010959;GO:0022898;GO:0001954;GO:0050808;GO:0030155;GO:0061061;GO:0044699;GO:0032409;GO:0022610;GO:0015672;GO:0002028;GO:0032502;GO:0032501;GO:0009987;GO:0030001;GO:0032879;GO:0055085;GO:0001952;GO:0048731;GO:0031589;GO:0007275;GO:0043269;GO:0035725;GO:0010810;GO:0010811;GO:0044767;GO:0034220;GO:0044765;GO:0044763;GO:0007155;GO:0051179;GO:1902578;GO:0048856;GO:0098655;GO:0048522; regulation of transport;muscle system process;regulation of ion transmembrane transport;regulation of transmembrane transport;muscle organ development;positive regulation of cell adhesion;cellular component organization or biogenesis;animal organ development;positive regulation of biological process;inorganic cation transmembrane transport;regulation of sodium ion transmembrane transport;muscle contraction;inorganic ion transmembrane transport;neuromuscular junction development;regulation of cellular process;system process;cell-matrix adhesion;single-multicellular organism process;regulation of ion transmembrane transporter activity;regulation of cation transmembrane transport;regulation of biological process;cellular component organization;biological regulation;regulation of sodium ion transmembrane transporter activity;regulation of molecular function;cation transport;ion transport;transport;sodium ion transport;biological_process;establishment of localization;regulation of metal ion transport;regulation of transmembrane transporter activity;positive regulation of cell-matrix adhesion;synapse organization;regulation of cell adhesion;muscle structure development;single-organism process;regulation of transporter activity;biological adhesion;monovalent inorganic cation transport;regulation of sodium ion transport;developmental process;multicellular organismal process;cellular process;metal ion transport;regulation of localization;transmembrane transport;regulation of cell-matrix adhesion;system development;cell-substrate adhesion;multicellular organism development;regulation of ion transport;sodium ion transmembrane transport;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;single-organism developmental process;ion transmembrane transport;single-organism transport;single-organism cellular process;cell adhesion;localization;single-organism localization;anatomical structure development;cation transmembrane transport;positive regulation of cellular process; 4;4;5;4;5;4;2;4;2;7;7;5;6;5;3;3;5;3;6;6;2;3;2;7;3;6;5;4;8;1;3;6;5;6;4;4;4;2;4;2;7;7;2;2;2;7;3;4;6;4;4;4;5;8;5;5;3;5;4;3;3;2;3;3;6;3; GO:0030427;GO:0030426;GO:0031974;GO:0031594;GO:0097060;GO:0005654;GO:0042995;GO:0031982;GO:0031981;GO:0016020;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0098590;GO:0043232;GO:0030175;GO:0043229;GO:0043228;GO:0090665;GO:0043227;GO:0005856;GO:0044430;GO:0030054;GO:0098858;GO:0042383;GO:0031253;GO:0005938;GO:0030863;GO:0030864;GO:0044446;GO:0044444;GO:0044448;GO:0005737;GO:0005634;GO:0044456;GO:0043005;GO:0044459;GO:0045211;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0016010;GO:0015629;GO:0071944;GO:0045202;GO:0098797;GO:0070062;GO:0098796;GO:0098805;GO:0043226;GO:0097458;GO:0098794;GO:0098589;GO:0099568;GO:0005886;GO:1903561;GO:0032991;GO:0031527;GO:0005575;GO:0070013;GO:0005576; site of polarized growth;growth cone;membrane-enclosed lumen;neuromuscular junction;synaptic membrane;nucleoplasm;cell projection;vesicle;nuclear lumen;membrane;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;membrane part;extracellular region part;organelle part;plasma membrane region;intracellular non-membrane-bounded organelle;filopodium;intracellular organelle;non-membrane-bounded organelle;glycoprotein complex;membrane-bounded organelle;cytoskeleton;cytoskeletal part;cell junction;actin-based cell projection;sarcolemma;cell projection membrane;cell cortex;cortical cytoskeleton;cortical actin cytoskeleton;intracellular organelle part;cytoplasmic part;cell cortex part;cytoplasm;nucleus;synapse part;neuron projection;plasma membrane part;postsynaptic membrane;cell projection part;cell part;cell;intracellular;dystrophin-associated glycoprotein complex;actin cytoskeleton;cell periphery;synapse;plasma membrane protein complex;extracellular exosome;membrane protein complex;whole membrane;organelle;neuron part;postsynapse;membrane region;cytoplasmic region;plasma membrane;extracellular vesicle;macromolecular complex;filopodium membrane;cellular_component;intracellular organelle lumen;extracellular region; 3;4;2;3;3;5;3;4;5;2;3;3;4;3;4;3;2;2;2;4;4;5;3;3;4;3;5;4;2;4;4;4;4;6;5;3;4;5;4;5;2;4;3;4;3;2;2;3;5;6;3;2;4;4;3;3;2;3;3;3;5;3;3;2;5;1;4;2; GO:0008270;GO:0046872;GO:0044877;GO:0019900;GO:0050839;GO:0017166;GO:0003674;GO:0005488;GO:0046914;GO:0003779;GO:0008092;GO:0019899;GO:0043169;GO:0043167;GO:0032403;GO:0005515;GO:0005102;GO:0005178;GO:0019901; zinc ion binding;metal ion binding;macromolecular complex binding;kinase binding;cell adhesion molecule binding;vinculin binding;molecular_function;binding;transition metal ion binding;actin binding;cytoskeletal protein binding;enzyme binding;cation binding;ion binding;protein complex binding;protein binding;receptor binding;integrin binding;protein kinase binding; 7;5;3;5;4;5;1;2;6;5;4;4;4;3;4;3;4;5;6; IPR002017;IPR035436;IPR018159;IPR000433;IPR001715;IPR015154;IPR011992;IPR001589;IPR001202;IPR015153; Spectrin repeat;Dystrophin/utrophin;Spectrin/alpha-actinin;Zinc finger, ZZ-type;Calponin homology domain;EF-hand domain, type 2;EF-hand domain pair;Actinin-type actin-binding domain, conserved site;WW domain;EF-hand domain, type 1; nucleus Hs6005938 7036.0 NTZ [N] Cell motility;[T] Signal transduction mechanisms;[Z] Cytoskeleton; P13645 Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 - [K1C10_HUMAN] 1.049 0.895 0.865 1.043 1.129 1.175 1.172067039 0.002906854 0.923826395 0.906827314 0.966480447 0.199893641 1.040744021 0.009327733 GO:0030154;GO:0008544;GO:0044699;GO:0048869;GO:0007275;GO:0048513;GO:0030855;GO:0043588;GO:0032502;GO:0032501;GO:0030216;GO:0060429;GO:0009888;GO:0044767;GO:0008150;GO:0044707;GO:0009913;GO:0048856;GO:0044763;GO:0048731;GO:0009987; cell differentiation;epidermis development;single-organism process;cellular developmental process;multicellular organism development;animal organ development;epithelial cell differentiation;skin development;developmental process;multicellular organismal process;keratinocyte differentiation;epithelium development;tissue development;single-organism developmental process;biological_process;single-multicellular organism process;epidermal cell differentiation;anatomical structure development;single-organism cellular process;system development;cellular process; 5;6;2;4;4;4;6;5;2;2;6;5;4;3;1;3;7;3;3;4;2; GO:0099512;GO:0099513;GO:0043232;GO:0043229;GO:0043228;GO:0044430;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0045111;GO:0070062;GO:0005634;GO:0016020;GO:0005615;GO:0005856;GO:0005882;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;intermediate filament cytoskeleton;extracellular exosome;nucleus;membrane;extracellular space;cytoskeleton;intermediate filament;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;4;3;3;4;3;2;4;3;6;4;5;2;3;5;4;3;4;3;4;2;2;3;1;2;3;2;2; GO:0003674;GO:0030280;GO:0005198; molecular_function;structural constituent of epidermis;structural molecule activity; 1;3;2; K07604 IPR001664;IPR018039;IPR002957; Intermediate filament protein;Intermediate filament protein, conserved site;Keratin, type I; nucleus P50851 Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4 - [LRBA_HUMAN] 1.135 1.213 0.602 0.928 1.668 nan 0.93569662 nan 0.556354916 nan 0.49629019 nan nan nan GO:0000323;GO:0005783;GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0005575;GO:0005773;GO:0016021;GO:0016020;GO:0005794;GO:0012505;GO:0005886;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005764;GO:0044444;GO:0044424;GO:0044425; lytic vacuole;endoplasmic reticulum;intracellular organelle;cell periphery;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;cellular_component;vacuole;integral component of membrane;membrane;Golgi apparatus;endomembrane system;plasma membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;lysosome;cytoplasmic part;intracellular part;membrane part; 6;4;3;3;3;2;3;4;1;5;4;2;4;3;3;4;2;2;3;7;4;3;2; IPR016024;IPR017986;IPR001680;IPR015943;IPR013320;IPR031570;IPR010508;IPR011993;IPR011989;IPR023362;IPR000409; Armadillo-type fold;WD40-repeat-containing domain;WD40 repeat;WD40/YVTN repeat-like-containing domain;Concanavalin A-like lectin/glucanase domain;Domain of unknown function DUF4704;Domain of unknown function DUF1088;PH domain-like;Armadillo-like helical;PH-BEACH domain;BEACH domain; plasma membrane Hs16904381 5953.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q6P3W7 SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1 - [SCYL2_HUMAN] 0.933 0.824 1.499 1.032 0.944 0.658 1.132281553 0.34912515 1.093220339 0.434632038 1.819174757 0.009154132 0.697033898 0.288984785 GO:0019222;GO:0051049;GO:0048585;GO:0048583;GO:0030111;GO:0007165;GO:0007166;GO:0048260;GO:0071840;GO:0051716;GO:0010604;GO:0009968;GO:0009966;GO:0048518;GO:0048519;GO:0051050;GO:0060255;GO:0016197;GO:0044700;GO:0016192;GO:0016055;GO:0060828;GO:0009893;GO:0044260;GO:0016043;GO:0065007;GO:0051130;GO:2000370;GO:0006810;GO:0044710;GO:0050794;GO:0060070;GO:0008150;GO:0008152;GO:0048259;GO:0051234;GO:0006897;GO:0046907;GO:0050896;GO:0006898;GO:0030178;GO:2000369;GO:0008333;GO:0072583;GO:0051128;GO:0023057;GO:0023052;GO:0010648;GO:0007041;GO:0023051;GO:0010646;GO:0044699;GO:0009987;GO:0060627;GO:0032879;GO:0031623;GO:0007034;GO:2000286;GO:0043170;GO:0031325;GO:0031323;GO:0002090;GO:0050789;GO:0071704;GO:0090090;GO:0044765;GO:0044763;GO:0002092;GO:0051649;GO:0007154;GO:0030100;GO:0051179;GO:1902578;GO:0051641;GO:0044237;GO:1902582;GO:0045807;GO:0043112;GO:0048523;GO:0048522; regulation of metabolic process;regulation of transport;negative regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;positive regulation of receptor-mediated endocytosis;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;positive regulation of biological process;negative regulation of biological process;positive regulation of transport;regulation of macromolecule metabolic process;endosomal transport;single organism signaling;vesicle-mediated transport;Wnt signaling pathway;regulation of canonical Wnt signaling pathway;positive regulation of metabolic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;positive regulation of cellular component organization;positive regulation of clathrin-mediated endocytosis;transport;single-organism metabolic process;regulation of cellular process;canonical Wnt signaling pathway;biological_process;metabolic process;regulation of receptor-mediated endocytosis;establishment of localization;endocytosis;intracellular transport;response to stimulus;receptor-mediated endocytosis;negative regulation of Wnt signaling pathway;regulation of clathrin-mediated endocytosis;endosome to lysosome transport;clathrin-mediated endocytosis;regulation of cellular component organization;negative regulation of signaling;signaling;negative regulation of cell communication;lysosomal transport;regulation of signaling;regulation of cell communication;single-organism process;cellular process;regulation of vesicle-mediated transport;regulation of localization;receptor internalization;vacuolar transport;receptor internalization involved in canonical Wnt signaling pathway;macromolecule metabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of receptor internalization;regulation of biological process;organic substance metabolic process;negative regulation of canonical Wnt signaling pathway;single-organism transport;single-organism cellular process;positive regulation of receptor internalization;establishment of localization in cell;cell communication;regulation of endocytosis;localization;single-organism localization;cellular localization;cellular metabolic process;single-organism intracellular transport;positive regulation of endocytosis;receptor metabolic process;negative regulation of cellular process;positive regulation of cellular process; 3;4;3;3;5;4;5;5;2;3;4;4;4;2;2;3;4;7;3;5;6;6;3;4;3;2;4;6;4;3;3;7;1;2;6;3;6;5;2;7;5;7;8;8;4;3;2;4;7;3;4;2;2;4;3;4;6;5;4;4;4;5;2;3;6;4;3;5;4;4;5;2;3;3;3;5;4;5;3;3; GO:0016020;GO:0031988;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0043229;GO:0005773;GO:0005622;GO:0043227;GO:0043226;GO:0044437;GO:0048471;GO:0012505;GO:0031982;GO:0016023;GO:0044444;GO:0044422;GO:0044440;GO:0097708;GO:0010008;GO:0005737;GO:0031090;GO:0031410;GO:0005774;GO:0044464;GO:0005623;GO:0030135;GO:0030136;GO:0044446;GO:0098805;GO:0005575;GO:0005768; membrane;membrane-bounded vesicle;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;vacuole;intracellular;membrane-bounded organelle;organelle;vacuolar part;perinuclear region of cytoplasm;endomembrane system;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;organelle part;endosomal part;intracellular vesicle;endosome membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;vacuolar membrane;cell part;cell;coated vesicle;clathrin-coated vesicle;intracellular organelle part;whole membrane;cellular_component;endosome; 2;5;4;4;4;3;3;5;3;3;2;4;5;3;4;5;4;2;5;4;5;4;3;5;4;2;2;6;7;3;3;1;4; GO:1901363;GO:0016740;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0016301;GO:0000166;GO:0003824;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0005515;GO:0097159;GO:0005102;GO:0001883;GO:0004672;GO:0001882;GO:0036094; heterocyclic compound binding;transferase activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;kinase activity;nucleotide binding;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;protein binding;organic cyclic compound binding;receptor binding;purine nucleoside binding;protein kinase activity;nucleoside binding;small molecule binding; 3;3;3;1;2;4;5;5;6;4;5;4;2;5;4;6;5;6;4;5;3;6;3;3;4;5;6;4;3; K17541 IPR016024;IPR011989;IPR011009;IPR000719; Armadillo-type fold;Armadillo-like helical;Protein kinase-like domain;Protein kinase domain; cytosol Hs8922218 667.0 T [T] Signal transduction mechanisms; Q9P2K2 Thioredoxin domain-containing protein 16 OS=Homo sapiens OX=9606 GN=TXNDC16 PE=1 SV=4 - [TXD16_HUMAN] 1.246 0.863 0.865 1.599 0.793 0.807 1.443800695 nan 2.016393443 nan 1.002317497 nan 1.017654477 nan GO:0042592;GO:0044699;GO:0050789;GO:0065007;GO:0065008;GO:0019725;GO:0009987;GO:0050794;GO:0008150;GO:0045454;GO:0044763; homeostatic process;single-organism process;regulation of biological process;biological regulation;regulation of biological quality;cellular homeostasis;cellular process;regulation of cellular process;biological_process;cell redox homeostasis;single-organism cellular process; 4;2;2;2;3;4;2;3;1;4;3; GO:0005783;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070062;GO:0044432;GO:0005788;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0005576;GO:0044424;GO:0044421;GO:0044422;GO:0012505; endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;extracellular exosome;endoplasmic reticulum part;endoplasmic reticulum lumen;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;extracellular region;intracellular part;extracellular region part;organelle part;endomembrane system; 4;2;3;3;2;4;3;4;4;5;3;4;3;4;3;2;2;3;1;4;4;2;3;2;2;3; IPR013766;IPR012336; Thioredoxin domain;Thioredoxin-like fold; plasma membrane Hs22048178 1018.0 O [O] Posttranslational modification, protein turnover, chaperones; O60293 Zinc finger C3H1 domain-containing protein OS=Homo sapiens OX=9606 GN=ZFC3H1 PE=1 SV=3 - [ZC3H1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0090304;GO:0034641;GO:0006807;GO:1901360;GO:0044260;GO:0071704;GO:0010467;GO:0006139;GO:0009987;GO:0006725;GO:0008150;GO:0008152;GO:0046483;GO:0016070;GO:0044238;GO:0044237;GO:0043170;GO:0006396; nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;organic cyclic compound metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;gene expression;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;biological_process;metabolic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular metabolic process;macromolecule metabolic process;RNA processing; 5;4;3;4;4;3;5;4;2;4;1;2;4;5;3;3;4;6; GO:0005615;GO:0005575;GO:0005576;GO:0044421; extracellular space;cellular_component;extracellular region;extracellular region part; 3;1;2;2; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0043169;GO:0043167;GO:0046872;GO:0044822;GO:0097159;GO:0003723; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;cation binding;ion binding;metal ion binding;poly(A) RNA binding;organic cyclic compound binding;RNA binding; 1;2;4;3;4;3;5;6;3;5; IPR003107;IPR013026;IPR019607;IPR011990; HAT (Half-A-TPR) repeat;Tetratricopeptide repeat-containing domain;Putative zinc-finger domain;Tetratricopeptide-like helical domain; nucleus Hs22058499 1583.0 S [S] Function unknown; P14625 Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1 - [ENPL_HUMAN] 0.816 0.746 1.433 1.063 0.692 1.16 1.09383378 0.867017789 1.536127168 0.337326417 1.920911528 0.393257828 1.676300578 0.257938378 GO:0008104;GO:0019220;GO:0019222;GO:0006470;GO:0048584;GO:0048583;GO:0031349;GO:0055080;GO:0065009;GO:0055074;GO:0098771;GO:0035304;GO:0044712;GO:0006984;GO:0044710;GO:0006986;GO:0070727;GO:0071840;GO:0071310;GO:0051208;GO:0016311;GO:0014070;GO:0048518;GO:0048519;GO:0033036;GO:0019725;GO:0060255;GO:0060548;GO:0045184;GO:0050776;GO:0010033;GO:0016192;GO:0044700;GO:0030968;GO:0019538;GO:0010243;GO:0048878;GO:0002376;GO:0007154;GO:0033554;GO:0007165;GO:0022607;GO:0031323;GO:0055065;GO:0036503;GO:0036500;GO:0031247;GO:0032527;GO:0008219;GO:0044267;GO:1901575;GO:0044265;GO:0002764;GO:0044260;GO:0044085;GO:0006886;GO:0006955;GO:0030970;GO:0016043;GO:0009719;GO:0002684;GO:0065007;GO:0031347;GO:0065008;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0051238;GO:0051235;GO:0051234;GO:0072503;GO:0051336;GO:0051603;GO:0002757;GO:0006897;GO:0043666;GO:0046907;GO:0036293;GO:0050896;GO:1901699;GO:0010498;GO:0043412;GO:0002218;GO:0006511;GO:0061572;GO:0010921;GO:0050801;GO:0051649;GO:0044248;GO:0023052;GO:0070887;GO:0006457;GO:0014074;GO:0001666;GO:0035303;GO:0044699;GO:0072507;GO:0043161;GO:1901698;GO:0051246;GO:0051179;GO:0031399;GO:0002224;GO:0006508;GO:0051641;GO:0002221;GO:0071495;GO:1901700;GO:0044238;GO:0006875;GO:0006874;GO:0009987;GO:0019941;GO:0006873;GO:1901701;GO:0030003;GO:0044257;GO:0007010;GO:0055082;GO:0042592;GO:0032268;GO:0071407;GO:0050778;GO:0043170;GO:0035967;GO:0035966;GO:0033198;GO:0034975;GO:0080134;GO:0034976;GO:0006898;GO:0043933;GO:0002758;GO:1903513;GO:0051174;GO:0030036;GO:0034620;GO:0043632;GO:0010941;GO:0002682;GO:0071822;GO:0042981;GO:0071417;GO:0006796;GO:0050789;GO:0071704;GO:0043067;GO:0043066;GO:0071702;GO:0071318;GO:0043069;GO:0046683;GO:0045089;GO:0045088;GO:0030029;GO:0051017;GO:0045087;GO:0034613;GO:0080090;GO:0006464;GO:0044765;GO:0044763;GO:0030433;GO:0042221;GO:0009056;GO:0009057;GO:1902578;GO:0070482;GO:0006996;GO:0009628;GO:0007015;GO:0050790;GO:0044237;GO:1902589;GO:0048523;GO:0002253;GO:0006793;GO:0015031;GO:1902582;GO:0006915;GO:0030163; protein localization;regulation of phosphate metabolic process;regulation of metabolic process;protein dephosphorylation;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of defense response;cation homeostasis;regulation of molecular function;calcium ion homeostasis;inorganic ion homeostasis;regulation of protein dephosphorylation;single-organism catabolic process;ER-nucleus signaling pathway;single-organism metabolic process;response to unfolded protein;cellular macromolecule localization;cellular component organization or biogenesis;cellular response to organic substance;sequestering of calcium ion;dephosphorylation;response to organic cyclic compound;positive regulation of biological process;negative regulation of biological process;macromolecule localization;cellular homeostasis;regulation of macromolecule metabolic process;negative regulation of cell death;establishment of protein localization;regulation of immune response;response to organic substance;vesicle-mediated transport;single organism signaling;endoplasmic reticulum unfolded protein response;protein metabolic process;response to organonitrogen compound;chemical homeostasis;immune system process;cell communication;cellular response to stress;signal transduction;cellular component assembly;regulation of cellular metabolic process;metal ion homeostasis;ERAD pathway;ATF6-mediated unfolded protein response;actin rod assembly;protein exit from endoplasmic reticulum;cell death;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;cellular component biogenesis;intracellular protein transport;immune response;retrograde protein transport, ER to cytosol;cellular component organization;response to endogenous stimulus;positive regulation of immune system process;biological regulation;regulation of defense response;regulation of biological quality;transport;cellular response to stimulus;regulation of cellular process;defense response;programmed cell death;response to stress;protein modification process;biological_process;metabolic process;sequestering of metal ion;maintenance of location;establishment of localization;cellular divalent inorganic cation homeostasis;regulation of hydrolase activity;proteolysis involved in cellular protein catabolic process;immune response-activating signal transduction;endocytosis;regulation of phosphoprotein phosphatase activity;intracellular transport;response to decreased oxygen levels;response to stimulus;cellular response to nitrogen compound;proteasomal protein catabolic process;macromolecule modification;activation of innate immune response;ubiquitin-dependent protein catabolic process;actin filament bundle organization;regulation of phosphatase activity;ion homeostasis;establishment of localization in cell;cellular catabolic process;signaling;cellular response to chemical stimulus;protein folding;response to purine-containing compound;response to hypoxia;regulation of dephosphorylation;single-organism process;divalent inorganic cation homeostasis;proteasome-mediated ubiquitin-dependent protein catabolic process;response to nitrogen compound;regulation of protein metabolic process;localization;regulation of protein modification process;toll-like receptor signaling pathway;proteolysis;cellular localization;pattern recognition receptor signaling pathway;cellular response to endogenous stimulus;response to oxygen-containing compound;primary metabolic process;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular process;modification-dependent protein catabolic process;cellular ion homeostasis;cellular response to oxygen-containing compound;cellular cation homeostasis;cellular protein catabolic process;cytoskeleton organization;cellular chemical homeostasis;homeostatic process;regulation of cellular protein metabolic process;cellular response to organic cyclic compound;positive regulation of immune response;macromolecule metabolic process;cellular response to topologically incorrect protein;response to topologically incorrect protein;response to ATP;protein folding in endoplasmic reticulum;regulation of response to stress;response to endoplasmic reticulum stress;receptor-mediated endocytosis;macromolecular complex subunit organization;innate immune response-activating signal transduction;endoplasmic reticulum to cytosol transport;regulation of phosphorus metabolic process;actin cytoskeleton organization;cellular response to unfolded protein;modification-dependent macromolecule catabolic process;regulation of cell death;regulation of immune system process;protein complex subunit organization;regulation of apoptotic process;cellular response to organonitrogen compound;phosphate-containing compound metabolic process;regulation of biological process;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;organic substance transport;cellular response to ATP;negative regulation of programmed cell death;response to organophosphorus;positive regulation of innate immune response;regulation of innate immune response;actin filament-based process;actin filament bundle assembly;innate immune response;cellular protein localization;regulation of primary metabolic process;cellular protein modification process;single-organism transport;single-organism cellular process;ER-associated ubiquitin-dependent protein catabolic process;response to chemical;catabolic process;macromolecule catabolic process;single-organism localization;response to oxygen levels;organelle organization;response to abiotic stimulus;actin filament organization;regulation of catalytic activity;cellular metabolic process;single-organism organelle organization;negative regulation of cellular process;activation of immune response;phosphorus metabolic process;protein transport;single-organism intracellular transport;apoptotic process;protein catabolic process; 4;6;3;7;3;3;4;7;3;9;7;7;4;5;3;5;4;2;5;5;6;5;2;2;3;4;4;4;4;4;4;5;3;5;4;4;5;2;4;4;4;4;4;8;4;6;6;6;4;5;4;5;5;4;3;6;3;5;3;3;3;2;5;3;4;3;3;4;5;3;5;1;2;4;3;3;8;5;6;4;6;7;5;5;2;5;6;5;4;8;7;6;6;4;4;2;4;3;5;4;7;2;8;7;4;5;2;6;7;5;3;6;4;4;3;8;9;2;7;6;5;7;6;5;5;4;5;6;4;4;5;4;5;4;4;5;7;4;5;6;5;5;6;6;4;3;5;6;5;5;2;3;5;6;5;6;5;5;5;5;4;5;4;5;4;6;4;3;5;3;3;5;3;4;4;3;6;4;3;4;3;3;4;5;5;6;5; GO:0005783;GO:0042470;GO:0005788;GO:0005789;GO:0030054;GO:0030055;GO:0031983;GO:0031982;GO:0071682;GO:0016023;GO:0016020;GO:0031988;GO:0098588;GO:0031974;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0030496;GO:0043229;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0044433;GO:0044432;GO:0005886;GO:0048471;GO:0070161;GO:0012505;GO:0044446;GO:0044444;GO:0031410;GO:0097708;GO:0031012;GO:0042175;GO:0060205;GO:0005737;GO:0031090;GO:0005634;GO:0048770;GO:0005912;GO:0044464;GO:0005623;GO:0005829;GO:0030139;GO:0071944;GO:0034663;GO:0070062;GO:0005622;GO:1903561;GO:0032991;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;melanosome;endoplasmic reticulum lumen;endoplasmic reticulum membrane;cell junction;cell-substrate junction;vesicle lumen;vesicle;endocytic vesicle lumen;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;bounding membrane of organelle;membrane-enclosed lumen;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;membrane part;extracellular region part;organelle part;midbody;intracellular organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;cytoplasmic vesicle part;endoplasmic reticulum part;plasma membrane;perinuclear region of cytoplasm;anchoring junction;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasmic vesicle;intracellular vesicle;extracellular matrix;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;organelle membrane;nucleus;pigment granule;adherens junction;cell part;cell;cytosol;endocytic vesicle;cell periphery;endoplasmic reticulum chaperone complex;extracellular exosome;intracellular;extracellular vesicle;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 4;7;5;3;2;3;4;4;6;5;2;5;4;2;3;3;4;3;3;2;2;2;3;3;4;5;3;2;4;4;3;5;3;3;3;4;5;4;2;3;5;4;3;5;6;4;2;2;5;6;3;4;4;3;3;2;1;4;2; GO:1901363;GO:0019903;GO:0019902;GO:0097367;GO:0003674;GO:0005488;GO:0003676;GO:0032549;GO:0017076;GO:0050750;GO:0005524;GO:0043168;GO:0043169;GO:0000166;GO:0005102;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0019899;GO:0005509;GO:0046872;GO:0030554;GO:0003723;GO:0005515;GO:0097159;GO:0001883;GO:0001882;GO:0046790;GO:1901265;GO:0070325;GO:0036094;GO:0043167; heterocyclic compound binding;protein phosphatase binding;phosphatase binding;carbohydrate derivative binding;molecular_function;binding;nucleic acid binding;ribonucleoside binding;purine nucleotide binding;low-density lipoprotein particle receptor binding;ATP binding;anion binding;cation binding;nucleotide binding;receptor binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;enzyme binding;calcium ion binding;metal ion binding;adenyl nucleotide binding;RNA binding;protein binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;virion binding;nucleoside phosphate binding;lipoprotein particle receptor binding;small molecule binding;ion binding; 3;6;5;3;1;2;4;5;5;6;6;4;4;4;4;6;5;6;4;5;4;6;5;6;5;3;3;5;4;3;4;5;3;3; K09487 map04141;map04151;map04621;map04626;map04915;map04918;map05200;map05215; Protein processing in endoplasmic reticulum;PI3K-Akt signaling pathway;NOD-like receptor signaling pathway;Plant-pathogen interaction;Estrogen signaling pathway;Thyroid hormone synthesis;Pathways in cancer;Prostate cancer; IPR020575;IPR001404;IPR019805;IPR003594;IPR020568; Heat shock protein Hsp90, N-terminal;Heat shock protein Hsp90 family;Heat shock protein Hsp90, conserved site;Histidine kinase-like ATPase, C-terminal domain;Ribosomal protein S5 domain 2-type fold; endoplasmic reticulum Hs4507677 1640.0 O [O] Posttranslational modification, protein turnover, chaperones; Q12913 Receptor-type tyrosine-protein phosphatase eta OS=Homo sapiens OX=9606 GN=PTPRJ PE=1 SV=3 - [PTPRJ_HUMAN] 0.96 1.028 1.256 0.972 0.938 0.941 0.93385214 nan 1.036247335 nan 1.221789883 nan 1.003198294 nan GO:0051348;GO:0019220;GO:0080090;GO:0019222;GO:1901890;GO:0006470;GO:0048585;GO:0048584;GO:0060242;GO:0007160;GO:0051898;GO:0007165;GO:0007166;GO:0007167;GO:0051893;GO:0007169;GO:0090109;GO:0051897;GO:0051896;GO:0071840;GO:0051894;GO:0051716;GO:0032879;GO:0010605;GO:0009968;GO:0045785;GO:0009966;GO:0009967;GO:0000165;GO:0044092;GO:0048518;GO:0048519;GO:0043407;GO:0002683;GO:0042127;GO:0031589;GO:0006935;GO:1901888;GO:0060255;GO:0048583;GO:0045859;GO:0042221;GO:0050776;GO:0007173;GO:0003008;GO:0042325;GO:0044700;GO:0042326;GO:0009605;GO:0044089;GO:0019538;GO:0048870;GO:0007045;GO:0002376;GO:0003013;GO:0010648;GO:0033673;GO:0022607;GO:0009892;GO:0030336;GO:0050852;GO:0001952;GO:0003018;GO:0048008;GO:0051674;GO:1903393;GO:1901184;GO:1901185;GO:0050789;GO:0044267;GO:0016049;GO:0002764;GO:0044260;GO:0002768;GO:0043549;GO:0016043;GO:0010640;GO:0050858;GO:0002684;GO:0065007;GO:0044699;GO:0065009;GO:0010642;GO:0051130;GO:0008015;GO:0050790;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:1902532;GO:1902533;GO:1902531;GO:0002757;GO:0042330;GO:0043491;GO:0050896;GO:0050918;GO:0051338;GO:2000145;GO:2000146;GO:0034330;GO:0030308;GO:0016311;GO:0016310;GO:0030155;GO:0051128;GO:0023057;GO:0043405;GO:0007044;GO:0023052;GO:0038127;GO:0023051;GO:0035335;GO:0010647;GO:0010646;GO:0043086;GO:0043408;GO:0051248;GO:0010563;GO:0051246;GO:0002429;GO:0031399;GO:0023014;GO:0022610;GO:0008285;GO:0031324;GO:0008283;GO:0009987;GO:0051271;GO:0050860;GO:0001558;GO:0071901;GO:0006928;GO:0034329;GO:0030334;GO:0032269;GO:0032268;GO:0065008;GO:0001954;GO:0050778;GO:0043170;GO:1903391;GO:0031400;GO:0002682;GO:0045926;GO:0034333;GO:0034332;GO:0031323;GO:0042059;GO:0042058;GO:0040013;GO:0016477;GO:0048041;GO:0035556;GO:0071900;GO:0045216;GO:0040007;GO:0040008;GO:0071704;GO:0044085;GO:0040012;GO:0043116;GO:0032501;GO:0050851;GO:0006468;GO:0006469;GO:0050854;GO:0050856;GO:0045936;GO:0010810;GO:0010811;GO:0006464;GO:0051174;GO:0044763;GO:0007155;GO:0007154;GO:0051179;GO:0023056;GO:0040011;GO:0044238;GO:0043409;GO:0051270;GO:0044237;GO:0043114;GO:0044087;GO:0006796;GO:0002253;GO:0006793;GO:0001933;GO:0001932;GO:0048523;GO:0048522; negative regulation of transferase activity;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of cell junction assembly;protein dephosphorylation;negative regulation of response to stimulus;positive regulation of response to stimulus;contact inhibition;cell-matrix adhesion;negative regulation of protein kinase B signaling;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of focal adhesion assembly;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of cell-substrate junction assembly;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;cellular component organization or biogenesis;positive regulation of focal adhesion assembly;cellular response to stimulus;regulation of localization;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;positive regulation of cell adhesion;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;negative regulation of MAP kinase activity;negative regulation of immune system process;regulation of cell proliferation;cell-substrate adhesion;chemotaxis;regulation of cell junction assembly;regulation of macromolecule metabolic process;regulation of response to stimulus;regulation of protein kinase activity;response to chemical;regulation of immune response;epidermal growth factor receptor signaling pathway;system process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;response to external stimulus;positive regulation of cellular component biogenesis;protein metabolic process;cell motility;cell-substrate adherens junction assembly;immune system process;circulatory system process;negative regulation of cell communication;negative regulation of kinase activity;cellular component assembly;negative regulation of metabolic process;negative regulation of cell migration;T cell receptor signaling pathway;regulation of cell-matrix adhesion;vascular process in circulatory system;platelet-derived growth factor receptor signaling pathway;localization of cell;positive regulation of adherens junction organization;regulation of ERBB signaling pathway;negative regulation of ERBB signaling pathway;regulation of biological process;cellular protein metabolic process;cell growth;immune response-regulating signaling pathway;cellular macromolecule metabolic process;immune response-regulating cell surface receptor signaling pathway;regulation of kinase activity;cellular component organization;regulation of platelet-derived growth factor receptor signaling pathway;negative regulation of antigen receptor-mediated signaling pathway;positive regulation of immune system process;biological regulation;single-organism process;regulation of molecular function;negative regulation of platelet-derived growth factor receptor signaling pathway;positive regulation of cellular component organization;blood circulation;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;immune response-activating signal transduction;taxis;protein kinase B signaling;response to stimulus;positive chemotaxis;regulation of transferase activity;regulation of cell motility;negative regulation of cell motility;cell junction organization;negative regulation of cell growth;dephosphorylation;phosphorylation;regulation of cell adhesion;regulation of cellular component organization;negative regulation of signaling;regulation of MAP kinase activity;cell-substrate junction assembly;signaling;ERBB signaling pathway;regulation of signaling;peptidyl-tyrosine dephosphorylation;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;regulation of MAPK cascade;negative regulation of protein metabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;immune response-activating cell surface receptor signaling pathway;regulation of protein modification process;signal transduction by protein phosphorylation;biological adhesion;negative regulation of cell proliferation;negative regulation of cellular metabolic process;cell proliferation;cellular process;negative regulation of cellular component movement;negative regulation of T cell receptor signaling pathway;regulation of cell growth;negative regulation of protein serine/threonine kinase activity;movement of cell or subcellular component;cell junction assembly;regulation of cell migration;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of biological quality;positive regulation of cell-matrix adhesion;positive regulation of immune response;macromolecule metabolic process;regulation of adherens junction organization;negative regulation of protein modification process;regulation of immune system process;negative regulation of growth;adherens junction assembly;adherens junction organization;regulation of cellular metabolic process;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;negative regulation of locomotion;cell migration;focal adhesion assembly;intracellular signal transduction;regulation of protein serine/threonine kinase activity;cell-cell junction organization;growth;regulation of growth;organic substance metabolic process;cellular component biogenesis;regulation of locomotion;negative regulation of vascular permeability;multicellular organismal process;antigen receptor-mediated signaling pathway;protein phosphorylation;negative regulation of protein kinase activity;regulation of antigen receptor-mediated signaling pathway;regulation of T cell receptor signaling pathway;negative regulation of phosphate metabolic process;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;cell adhesion;cell communication;localization;positive regulation of signaling;locomotion;primary metabolic process;negative regulation of MAPK cascade;regulation of cellular component movement;cellular metabolic process;regulation of vascular permeability;regulation of cellular component biogenesis;phosphate-containing compound metabolic process;activation of immune response;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;6;4;3;4;7;3;3;4;5;6;4;5;6;6;7;5;6;6;2;5;3;3;4;4;4;4;4;5;4;2;2;7;3;4;4;4;4;4;3;7;3;4;9;3;7;3;7;3;3;4;3;7;2;4;4;7;4;3;5;7;6;5;8;3;5;5;5;2;5;3;5;4;6;6;3;5;4;3;2;2;3;5;4;5;4;3;3;5;5;1;2;3;5;5;5;4;3;6;2;5;5;4;4;4;4;6;6;4;4;3;7;6;2;8;3;8;4;4;5;6;5;5;5;5;6;4;2;4;4;3;2;4;5;4;9;4;5;5;5;5;3;6;4;4;5;6;3;3;6;6;4;6;6;3;4;6;5;8;5;2;3;3;3;3;5;2;6;7;8;5;6;6;5;5;6;5;3;3;4;2;3;2;3;6;4;3;4;3;5;3;4;7;7;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0032587;GO:0044463;GO:0043230;GO:0030054;GO:0044425;GO:0044421;GO:0098590;GO:0042995;GO:0043227;GO:0031252;GO:0031256;GO:0031253;GO:0001772;GO:0031226;GO:0031224;GO:0044459;GO:0009986;GO:0005911;GO:0044464;GO:0005623;GO:0071944;GO:0001726;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0070062;GO:0098589;GO:0005575;GO:0005576;GO:0098805; vesicle;integral component of membrane;membrane;ruffle membrane;cell projection part;extracellular organelle;cell junction;membrane part;extracellular region part;plasma membrane region;cell projection;membrane-bounded organelle;cell leading edge;leading edge membrane;cell projection membrane;immunological synapse;intrinsic component of plasma membrane;intrinsic component of membrane;plasma membrane part;cell surface;cell-cell junction;cell part;cell;cell periphery;ruffle;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;extracellular exosome;membrane region;cellular_component;extracellular region;whole membrane; 4;4;2;5;3;3;2;2;2;4;3;3;3;4;4;4;4;3;3;3;3;2;2;3;4;2;4;3;3;4;3;1;2;3; GO:0019901;GO:0019900;GO:0004725;GO:0003674;GO:0005488;GO:0016787;GO:0016788;GO:0003824;GO:0008013;GO:0004721;GO:0016791;GO:0019899;GO:0042578;GO:0051019;GO:0005515;GO:0005102;GO:0005161;GO:0070097;GO:0045295;GO:0070851; protein kinase binding;kinase binding;protein tyrosine phosphatase activity;molecular_function;binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;beta-catenin binding;phosphoprotein phosphatase activity;phosphatase activity;enzyme binding;phosphoric ester hydrolase activity;mitogen-activated protein kinase binding;protein binding;receptor binding;platelet-derived growth factor receptor binding;delta-catenin binding;gamma-catenin binding;growth factor receptor binding; 6;5;8;1;2;3;4;2;4;7;6;4;5;7;3;4;6;4;4;5; K05698 map04520; Adherens junction; IPR016130;IPR013783;IPR029021;IPR003961;IPR003595;IPR000387;IPR000242; Protein-tyrosine phosphatase, active site;Immunoglobulin-like fold;Protein-tyrosine phosphatase-like;Fibronectin type III;Protein-tyrosine phosphatase, catalytic;Tyrosine specific protein phosphatases domain;PTP type protein phosphatase; plasma membrane Hs18860900 2764.0 T [T] Signal transduction mechanisms; Q9ULG6 Cell cycle progression protein 1 OS=Homo sapiens OX=9606 GN=CCPG1 PE=1 SV=3 - [CCPG1_HUMAN] 1.004 1.079 1.245 0.819 1.188 0.456 0.930491196 0.219022648 0.689393939 0.004363636 1.153846154 0.052522099 0.383838384 0.001610252 GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0045787;GO:0048518;GO:0042127;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0051252;GO:0009893;GO:0009891;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0007049;GO:0006366;GO:0065009;GO:0018130;GO:0050790;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0010604;GO:0051336;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:1905097;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0043087;GO:0006139;GO:1903508;GO:0016070;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:2001106;GO:0044699;GO:0051098;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0045944;GO:0008284;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:2000112;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044238;GO:0051726;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of cell cycle;positive regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;regulation of RNA metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;cell cycle;transcription from RNA polymerase II promoter;regulation of molecular function;heterocycle biosynthetic process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of macromolecule metabolic process;regulation of hydrolase activity;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;regulation of guanyl-nucleotide exchange factor activity;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;regulation of GTPase activity;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;RNA metabolic process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of Rho guanyl-nucleotide exchange factor activity;single-organism process;regulation of binding;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cell proliferation;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;regulation of cell cycle;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;2;4;4;6;4;5;5;3;4;3;2;7;4;4;2;4;7;3;5;4;4;3;1;2;5;4;5;5;6;5;5;6;3;6;4;4;5;6;4;7;5;3;2;4;7;6;4;2;4;5;4;6;5;7;4;5;5;4;4;5;6;3;5;7;5;5;5;3;5;3;4;4;3;4;3;3; GO:0016021;GO:0016020;GO:0044425;GO:0031224;GO:0005575; integral component of membrane;membrane;membrane part;intrinsic component of membrane;cellular_component; 4;2;2;3;1; IPR033588; Cell cycle progression protein 1; cytosol Q8N109 Killer cell immunoglobulin-like receptor 2DL5A OS=Homo sapiens OX=9606 GN=KIR2DL5A PE=3 SV=1 - [KI2LA_HUMAN] 1.012 1.1 0.807 1.198 1.132 0.989 0.92 0.393864201 1.058303887 0.361750195 0.733636364 0.000140926 0.873674912 0.974541546 GO:0016021;GO:0016020;GO:0044464;GO:0005623;GO:0005575;GO:0071944;GO:0005886;GO:0044425;GO:0031224; integral component of membrane;membrane;cell part;cell;cellular_component;cell periphery;plasma membrane;membrane part;intrinsic component of membrane; 4;2;2;2;1;3;3;2;3; K07981 map04612;map04650; Antigen processing and presentation;Natural killer cell mediated cytotoxicity; IPR003599;IPR007110;IPR013783;IPR013151; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin; plasma membrane Q6NUT2 Probable C-mannosyltransferase DPY19L2 OS=Homo sapiens OX=9606 GN=DPY19L2 PE=1 SV=2 - [D19L2_HUMAN] 1.105 1.078 1.236 0.627 0.997 1.078 1.025046382 nan 0.62888666 nan 1.146567718 nan 1.081243731 nan GO:0048468;GO:0035268;GO:0044710;GO:0000003;GO:0048869;GO:0018193;GO:0018211;GO:0048515;GO:0007281;GO:0003006;GO:0007283;GO:0007286;GO:0051704;GO:0044703;GO:0044702;GO:0044707;GO:0019538;GO:1901576;GO:0044260;GO:0044699;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0043413;GO:0030154;GO:0019953;GO:0044249;GO:0034645;GO:0018317;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0009987;GO:0048232;GO:1901137;GO:1901135;GO:0043170;GO:0018103;GO:0009100;GO:0009101;GO:0007276;GO:0006486;GO:0007275;GO:0071704;GO:0018406;GO:0044267;GO:0070085;GO:0006464;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0022412;GO:0044238;GO:0005975;GO:0048856;GO:0097502;GO:0044237; cell development;protein mannosylation;single-organism metabolic process;reproduction;cellular developmental process;peptidyl-amino acid modification;peptidyl-tryptophan modification;spermatid differentiation;germ cell development;developmental process involved in reproduction;spermatogenesis;spermatid development;multi-organism process;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;protein metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;single-organism process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;macromolecule glycosylation;cell differentiation;sexual reproduction;cellular biosynthetic process;cellular macromolecule biosynthetic process;protein C-linked glycosylation via tryptophan;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cellular process;male gamete generation;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;protein C-linked glycosylation;glycoprotein metabolic process;glycoprotein biosynthetic process;gamete generation;protein glycosylation;multicellular organism development;organic substance metabolic process;protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;cellular protein metabolic process;glycosylation;cellular protein modification process;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cellular process involved in reproduction in multicellular organism;primary metabolic process;carbohydrate metabolic process;anatomical structure development;mannosylation;cellular metabolic process; 4;5;3;2;4;7;8;4;4;3;6;5;2;3;3;3;4;4;4;2;5;5;1;2;4;6;5;3;4;5;6;2;2;3;3;2;5;5;4;4;5;5;6;4;4;4;3;6;5;5;6;3;2;3;5;3;4;3;4;3;6;3; GO:0031975;GO:0016021;GO:0016020;GO:0031965;GO:0031967;GO:0043231;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0019866;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0044446;GO:0031224;GO:0031090;GO:0005637;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005575; envelope;integral component of membrane;membrane;nuclear membrane;organelle envelope;intracellular membrane-bounded organelle;nuclear part;intracellular part;membrane part;organelle part;organelle inner membrane;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;intracellular organelle part;intrinsic component of membrane;organelle membrane;nuclear inner membrane;nucleus;nuclear envelope;cell part;cell;cellular_component; 3;4;2;4;4;4;4;3;2;2;4;3;3;3;2;3;3;3;3;5;5;4;2;2;1; GO:0016740;GO:0016757;GO:0003674;GO:0003824;GO:0016758;GO:0000030; transferase activity;transferase activity, transferring glycosyl groups;molecular_function;catalytic activity;transferase activity, transferring hexosyl groups;mannosyltransferase activity; 3;4;1;2;5;6; IPR030042;IPR018732; Probable C-mannosyltransferase DPY19L2;Dpy-19/Dpy-19-like; plasma membrane Hs20541809 773.0 S [S] Function unknown; Q14166 Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2 - [TTL12_HUMAN] 0.735 1.003 1.437 0.876 0.978 1.112 0.732801595 0.182201412 0.895705521 0.439738031 1.432701894 0.198435033 1.137014315 0.488532514 GO:0044267;GO:0044260;GO:0071704;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0044237;GO:0043170; cellular protein metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;cellular metabolic process;macromolecule metabolic process; 5;4;3;2;6;5;5;1;2;3;4;3;4; GO:0035639;GO:0003674;GO:0005488;GO:0000166;GO:1901363;GO:1901265;GO:0001882;GO:0043168;GO:0043167;GO:0001883;GO:0032549;GO:0017076;GO:0005524;GO:0036094;GO:0030554;GO:0097159;GO:0097367;GO:0032559;GO:0032555;GO:0032550;GO:0032553; purine ribonucleoside triphosphate binding;molecular_function;binding;nucleotide binding;heterocyclic compound binding;nucleoside phosphate binding;nucleoside binding;anion binding;ion binding;purine nucleoside binding;ribonucleoside binding;purine nucleotide binding;ATP binding;small molecule binding;adenyl nucleotide binding;organic cyclic compound binding;carbohydrate derivative binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding; 5;1;2;4;3;4;4;4;3;5;5;5;6;3;6;3;3;6;5;6;4; K16609 IPR013815;IPR004344;IPR027749; ATP-grasp fold, subdomain 1;Tubulin-tyrosine ligase/Tubulin polyglutamylase;Tubulin--tyrosine ligase-like protein 12; cytosol Hs11056036 1340.0 O [O] Posttranslational modification, protein turnover, chaperones; A0A075B6J6 Immunoglobulin lambda variable 3-22 OS=Homo sapiens OX=9606 GN=IGLV3-22 PE=3 SV=1 - [LV322_HUMAN] 1.127 0.982 1.185 1.068 0.88 0.617 1.147657841 0.392856278 1.213636364 0.011331553 1.206720978 0.344581282 0.701136364 0.027600756 IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P28331 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3 - [NDUS1_HUMAN] 0.88 0.956 1.445 0.922 0.787 1.359 0.920502092 nan 1.171537484 nan 1.511506276 nan 1.726810673 nan GO:0009167;GO:0044281;GO:0009161;GO:0007005;GO:0044710;GO:0071840;GO:0010257;GO:0009199;GO:0022900;GO:0022904;GO:0009205;GO:0046034;GO:0046128;GO:0055114;GO:0046483;GO:1901564;GO:0006163;GO:1901135;GO:0042391;GO:0022607;GO:0009141;GO:0009144;GO:0006807;GO:0006120;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0019637;GO:0065008;GO:0006119;GO:0006461;GO:0009150;GO:0012501;GO:0008150;GO:0008152;GO:0045333;GO:0006753;GO:0070271;GO:0016310;GO:0034641;GO:0009123;GO:0009126;GO:0009259;GO:0044699;GO:0006139;GO:0042278;GO:0033108;GO:0009987;GO:0006725;GO:0072593;GO:0055086;GO:0015980;GO:0008637;GO:0097031;GO:0043933;GO:0044237;GO:0034622;GO:0072521;GO:0006091;GO:0008219;GO:0071822;GO:0032981;GO:0071704;GO:1901657;GO:0006915;GO:0009117;GO:0009116;GO:0009119;GO:0042775;GO:0043623;GO:0042773;GO:0006996;GO:0044238;GO:0051881;GO:0019693;GO:0044763;GO:0006796;GO:0044085;GO:0006793; purine ribonucleoside monophosphate metabolic process;small molecule metabolic process;ribonucleoside monophosphate metabolic process;mitochondrion organization;single-organism metabolic process;cellular component organization or biogenesis;NADH dehydrogenase complex assembly;ribonucleoside triphosphate metabolic process;electron transport chain;respiratory electron transport chain;purine ribonucleoside triphosphate metabolic process;ATP metabolic process;purine ribonucleoside metabolic process;oxidation-reduction process;heterocycle metabolic process;organonitrogen compound metabolic process;purine nucleotide metabolic process;carbohydrate derivative metabolic process;regulation of membrane potential;cellular component assembly;nucleoside triphosphate metabolic process;purine nucleoside triphosphate metabolic process;nitrogen compound metabolic process;mitochondrial electron transport, NADH to ubiquinone;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;organophosphate metabolic process;regulation of biological quality;oxidative phosphorylation;protein complex assembly;purine ribonucleotide metabolic process;programmed cell death;biological_process;metabolic process;cellular respiration;nucleoside phosphate metabolic process;protein complex biogenesis;phosphorylation;cellular nitrogen compound metabolic process;nucleoside monophosphate metabolic process;purine nucleoside monophosphate metabolic process;ribonucleotide metabolic process;single-organism process;nucleobase-containing compound metabolic process;purine nucleoside metabolic process;mitochondrial respiratory chain complex assembly;cellular process;cellular aromatic compound metabolic process;reactive oxygen species metabolic process;nucleobase-containing small molecule metabolic process;energy derivation by oxidation of organic compounds;apoptotic mitochondrial changes;mitochondrial respiratory chain complex I biogenesis;macromolecular complex subunit organization;cellular metabolic process;cellular macromolecular complex assembly;purine-containing compound metabolic process;generation of precursor metabolites and energy;cell death;protein complex subunit organization;mitochondrial respiratory chain complex I assembly;organic substance metabolic process;glycosyl compound metabolic process;apoptotic process;nucleotide metabolic process;nucleoside metabolic process;ribonucleoside metabolic process;mitochondrial ATP synthesis coupled electron transport;cellular protein complex assembly;ATP synthesis coupled electron transport;organelle organization;primary metabolic process;regulation of mitochondrial membrane potential;ribose phosphate metabolic process;single-organism cellular process;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process; 8;4;7;5;3;2;7;7;4;5;8;8;7;4;4;4;6;4;4;4;6;7;3;6;3;5;2;4;4;3;5;5;7;5;1;2;5;5;4;6;4;6;7;6;2;4;6;6;2;4;4;4;4;6;5;4;3;6;5;4;4;5;6;3;4;6;6;5;6;7;6;6;4;3;5;5;3;5;3;4; GO:0031970;GO:0031974;GO:0031975;GO:0043209;GO:0016020;GO:1902494;GO:0031967;GO:0031966;GO:0043234;GO:0043231;GO:0043233;GO:0030964;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005743;GO:0044446;GO:0044444;GO:0098796;GO:1990204;GO:0005737;GO:0031090;GO:0005739;GO:0044455;GO:0005747;GO:0044464;GO:0005623;GO:0005622;GO:0005740;GO:0005746;GO:0070469;GO:0098803;GO:0098800;GO:0005759;GO:0005758;GO:0070013;GO:0045271;GO:0032991;GO:0005575;GO:0019866;GO:0098798; organelle envelope lumen;membrane-enclosed lumen;envelope;myelin sheath;membrane;catalytic complex;organelle envelope;mitochondrial membrane;protein complex;intracellular membrane-bounded organelle;organelle lumen;NADH dehydrogenase complex;mitochondrial part;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;mitochondrial inner membrane;intracellular organelle part;cytoplasmic part;membrane protein complex;oxidoreductase complex;cytoplasm;organelle membrane;mitochondrion;mitochondrial membrane part;mitochondrial respiratory chain complex I;cell part;cell;intracellular;mitochondrial envelope;mitochondrial respiratory chain;respiratory chain;respiratory chain complex;inner mitochondrial membrane protein complex;mitochondrial matrix;mitochondrial intermembrane space;intracellular organelle lumen;respiratory chain complex I;macromolecular complex;cellular_component;organelle inner membrane;mitochondrial protein complex; 3;2;3;3;2;4;4;4;3;4;3;4;4;3;2;2;3;3;2;5;3;4;3;3;4;3;5;3;5;2;2;3;5;4;3;4;4;5;4;4;4;2;1;4;4; GO:0046872;GO:0003674;GO:0005488;GO:0003954;GO:0043169;GO:0051539;GO:0003824;GO:0051536;GO:0051537;GO:0016491;GO:0043167;GO:0050136;GO:0008137;GO:0016655;GO:0016651;GO:0051540;GO:0009055; metal ion binding;molecular_function;binding;NADH dehydrogenase activity;cation binding;4 iron, 4 sulfur cluster binding;catalytic activity;iron-sulfur cluster binding;2 iron, 2 sulfur cluster binding;oxidoreductase activity;ion binding;NADH dehydrogenase (quinone) activity;NADH dehydrogenase (ubiquinone) activity;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;oxidoreductase activity, acting on NAD(P)H;metal cluster binding;electron carrier activity; 5;1;2;5;4;5;2;4;5;3;3;6;7;5;4;3;2; K03934 map00190;map01100;map04932;map05010;map05012;map05016; Oxidative phosphorylation;Metabolic pathways;Non-alcoholic fatty liver disease (NAFLD);Alzheimer's disease;Parkinson's disease;Huntington's disease; IPR012675;IPR001041;IPR000283;IPR015405;IPR019574;IPR006656;IPR006963;IPR010228; Beta-grasp domain;2Fe-2S ferredoxin-type iron-sulfur binding domain;NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site;NADH-quinone oxidoreductase, chain G, C-terminal;NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding;Molybdopterin oxidoreductase;Molybdopterin oxidoreductase, 4Fe-4S domain;NADH:ubiquinone oxidoreductase, subunit G; mitochondria Hs13637608 1506.0 C [C] Energy production and conversion; P11226 Mannose-binding protein C OS=Homo sapiens OX=9606 GN=MBL2 PE=1 SV=2 - [MBL2_HUMAN] 1.013 0.908 1.194 1.015 0.832 1.009 1.115638767 0.058282493 1.219951923 0.039597381 1.314977974 0.045492139 1.212740385 0.024536706 GO:0006909;GO:0051234;GO:0051049;GO:0048584;GO:0048583;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0009617;GO:0044419;GO:0051817;GO:0048518;GO:0065007;GO:0001906;GO:0044144;GO:0019724;GO:0051050;GO:0050830;GO:0051702;GO:0051707;GO:0044146;GO:0051704;GO:0009607;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0050789;GO:0044130;GO:0016043;GO:0002684;GO:0002682;GO:0051873;GO:0065008;GO:0051130;GO:0050792;GO:0006810;GO:0050794;GO:0006952;GO:0043903;GO:0043900;GO:0043901;GO:0008150;GO:0008152;GO:0006955;GO:0002526;GO:0006958;GO:0044126;GO:0006897;GO:0006953;GO:0050896;GO:0031640;GO:0006950;GO:0008228;GO:0006956;GO:0006954;GO:0051128;GO:0044110;GO:0051818;GO:0044116;GO:0044117;GO:0044699;GO:0050766;GO:0050764;GO:0006959;GO:0044364;GO:0051852;GO:0051851;GO:0001867;GO:0009987;GO:0060627;GO:0098542;GO:0048519;GO:0032879;GO:0006979;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0042742;GO:0045926;GO:0040007;GO:0072376;GO:0040008;GO:0071704;GO:0016032;GO:0045087;GO:0002449;GO:0044765;GO:0044764;GO:0016064;GO:0002443;GO:0030100;GO:0051179;GO:1902578;GO:0044238;GO:0051883;GO:0002250;GO:0002253;GO:0002252;GO:0048525;GO:0044403;GO:0045807;GO:0035821;GO:0048523;GO:0048522; phagocytosis;establishment of localization;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;response to bacterium;interspecies interaction between organisms;modification of morphology or physiology of other organism involved in symbiotic interaction;positive regulation of biological process;biological regulation;cell killing;modulation of growth of symbiont involved in interaction with host;B cell mediated immunity;positive regulation of transport;defense response to Gram-positive bacterium;interaction with symbiont;response to other organism;negative regulation of growth of symbiont involved in interaction with host;multi-organism process;response to biotic stimulus;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;regulation of biological process;negative regulation of growth of symbiont in host;cellular component organization;positive regulation of immune system process;regulation of immune system process;killing by host of symbiont cells;regulation of biological quality;positive regulation of cellular component organization;regulation of viral process;transport;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;regulation of multi-organism process;negative regulation of multi-organism process;biological_process;metabolic process;immune response;acute inflammatory response;complement activation, classical pathway;regulation of growth of symbiont in host;endocytosis;acute-phase response;response to stimulus;killing of cells of other organism;response to stress;opsonization;complement activation;inflammatory response;regulation of cellular component organization;growth involved in symbiotic interaction;disruption of cells of other organism involved in symbiotic interaction;growth of symbiont involved in interaction with host;growth of symbiont in host;single-organism process;positive regulation of phagocytosis;regulation of phagocytosis;humoral immune response;disruption of cells of other organism;disruption by host of symbiont cells;modification by host of symbiont morphology or physiology;complement activation, lectin pathway;cellular process;regulation of vesicle-mediated transport;defense response to other organism;negative regulation of biological process;regulation of localization;response to oxidative stress;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;defense response to bacterium;negative regulation of growth;growth;protein activation cascade;regulation of growth;organic substance metabolic process;viral process;innate immune response;lymphocyte mediated immunity;single-organism transport;multi-organism cellular process;immunoglobulin mediated immune response;leukocyte mediated immunity;regulation of endocytosis;localization;single-organism localization;primary metabolic process;killing of cells in other organism involved in symbiotic interaction;adaptive immune response;activation of immune response;immune effector process;negative regulation of viral process;symbiosis, encompassing mutualism through parasitism;positive regulation of endocytosis;modification of morphology or physiology of other organism;negative regulation of cellular process;positive regulation of cellular process; 5;3;4;3;3;5;2;3;4;4;3;4;2;2;2;4;6;3;6;4;3;4;2;3;5;3;4;2;2;5;3;3;3;5;3;4;4;4;3;4;4;3;3;1;2;3;6;5;4;6;7;2;3;3;4;4;5;4;3;5;4;5;2;5;6;4;4;5;5;5;2;4;4;2;3;4;4;5;4;4;5;3;2;3;3;3;4;4;5;4;3;7;4;5;2;3;3;4;4;3;3;4;4;4;3;3;3; GO:0043234;GO:0044421;GO:0005581;GO:0009986;GO:0044464;GO:0005623;GO:0005615;GO:0032991;GO:0005575;GO:0005576; protein complex;extracellular region part;collagen trimer;cell surface;cell part;cell;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;2;4;3;2;2;3;2;1;2; GO:0048029;GO:0003674;GO:0005488;GO:0005537;GO:0048306;GO:0046872;GO:0043169;GO:0043167;GO:0005509;GO:0005515;GO:0005102;GO:0030246;GO:0036094; monosaccharide binding;molecular_function;binding;mannose binding;calcium-dependent protein binding;metal ion binding;cation binding;ion binding;calcium ion binding;protein binding;receptor binding;carbohydrate binding;small molecule binding; 4;1;2;5;4;5;4;3;6;3;4;3;3; K03991 map04145;map04610;map05150; Phagosome;Complement and coagulation cascades;Staphylococcus aureus infection; IPR016186;IPR033990;IPR018378;IPR008160;IPR001304;IPR016187; C-type lectin-like/link domain;Collectin, C-type lectin-like domain;C-type lectin, conserved site;Collagen triple helix repeat;C-type lectin-like;C-type lectin fold; extracellular Hs4557739 504.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; Q9BXX2 Ankyrin repeat domain-containing protein 30B OS=Homo sapiens OX=9606 GN=ANKRD30B PE=2 SV=3 - [AN30B_HUMAN] 0.905 1.053 1.073 0.912 1.132 1.114 0.859449193 0.053482302 0.80565371 0.188085982 1.018993352 0.86799637 0.98409894 0.897753763 IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; cytosol 392412867 109.0 T [T] Signal transduction mechanisms; COG0666 Ankyrin repeat P78369 Claudin-10 OS=Homo sapiens OX=9606 GN=CLDN10 PE=1 SV=2 - [CLD10_HUMAN] 0.481 0.785 0.896 0.682 0.31 8.084 0.612738854 nan 2.2 nan 1.141401274 nan 26.07741935 nan GO:0016338;GO:0044699;GO:1902578;GO:0022610;GO:0098609;GO:0006811;GO:0006810;GO:0044765;GO:0008150;GO:0007155;GO:0051234;GO:0051179;GO:0098742; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;single-organism process;single-organism localization;biological adhesion;cell-cell adhesion;ion transport;transport;single-organism transport;biological_process;cell adhesion;establishment of localization;localization;cell-cell adhesion via plasma-membrane adhesion molecules; 6;2;3;2;4;5;4;4;1;3;3;2;5; GO:0071944;GO:0005923;GO:0005737;GO:0016021;GO:0016020;GO:0031224;GO:0070160;GO:0005911;GO:0005886;GO:0030054;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044425;GO:0043296; cell periphery;bicellular tight junction;cytoplasm;integral component of membrane;membrane;intrinsic component of membrane;occluding junction;cell-cell junction;plasma membrane;cell junction;cell part;cell;intracellular;cellular_component;intracellular part;membrane part;apical junction complex; 3;5;4;4;2;3;4;3;3;2;2;2;3;1;3;2;4; GO:0003674;GO:0005488;GO:0005198;GO:0042802;GO:0005515; molecular_function;binding;structural molecule activity;identical protein binding;protein binding; 1;2;2;4;3; K06087 map04514;map04530;map04670;map05160; Cell adhesion molecules (CAMs);Tight junction;Leukocyte transendothelial migration;Hepatitis C; IPR003554;IPR004031;IPR006187;IPR017974; Claudin-10;PMP-22/EMP/MP20/Claudin superfamily;Claudin;Claudin, conserved site; plasma membrane Q9UKE5 TRAF2 and NCK-interacting protein kinase OS=Homo sapiens OX=9606 GN=TNIK PE=1 SV=1 - [TNIK_HUMAN] 0.375 0.337 2.955 0.769 0.44 0.604 1.112759644 0.885383968 1.747727273 0.868058152 8.768545994 0.07473442 1.372727273 0.706550349 GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0032147;GO:0061024;GO:0007009;GO:0007165;GO:0007166;GO:0030182;GO:0032989;GO:0071840;GO:0050688;GO:0051716;GO:0010604;GO:0009966;GO:0009967;GO:0000165;GO:0045664;GO:0048869;GO:0044093;GO:0048518;GO:0002682;GO:0033036;GO:0051960;GO:0060255;GO:0048468;GO:0045859;GO:0016358;GO:0046330;GO:0072657;GO:0010975;GO:0009607;GO:0072659;GO:0051707;GO:0051704;GO:0042325;GO:0044700;GO:0042327;GO:0009605;GO:0019538;GO:0016055;GO:0002376;GO:0033554;GO:0010256;GO:0022604;GO:0044707;GO:0022607;GO:0009893;GO:0033674;GO:0043900;GO:0002831;GO:0031175;GO:0046328;GO:0035556;GO:0044267;GO:0007346;GO:1990778;GO:0051347;GO:0045937;GO:0044260;GO:0043549;GO:0016043;GO:0031344;GO:0065007;GO:0023014;GO:0002252;GO:0065009;GO:0007256;GO:0043085;GO:0050767;GO:0050793;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0048858;GO:1902533;GO:0031347;GO:1902531;GO:0034613;GO:0006952;GO:0043207;GO:0050896;GO:0080135;GO:0006950;GO:0051338;GO:0048812;GO:0048814;GO:0009615;GO:0002697;GO:0010562;GO:0051239;GO:0032101;GO:0016310;GO:0030154;GO:0031098;GO:0023056;GO:0043405;GO:0023052;GO:0023051;GO:0010647;GO:0010646;GO:0046777;GO:0044699;GO:0043408;GO:0000902;GO:0007254;GO:0009653;GO:0022603;GO:0051246;GO:0051247;GO:0060284;GO:0010769;GO:0032270;GO:0031399;GO:0032502;GO:0032501;GO:0070302;GO:0016236;GO:0009987;GO:0070304;GO:0032872;GO:0045595;GO:0098542;GO:0032874;GO:0044802;GO:0051607;GO:0007049;GO:0032268;GO:0050773;GO:0048813;GO:0043170;GO:0002230;GO:0070727;GO:0000904;GO:0048731;GO:0045860;GO:0080134;GO:0000186;GO:0031401;GO:0030030;GO:0030031;GO:0031325;GO:0030033;GO:0031323;GO:0030036;GO:0043506;GO:0044767;GO:0008219;GO:0010941;GO:0007275;GO:0051128;GO:0071900;GO:0031532;GO:0042981;GO:1902589;GO:0050789;GO:0071704;GO:0043067;GO:0044085;GO:0048666;GO:0048667;GO:0006468;GO:0000278;GO:0030029;GO:0006914;GO:0006915;GO:0032528;GO:0006464;GO:0050691;GO:0051174;GO:0051403;GO:0044763;GO:0007154;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0048699;GO:1902580;GO:0007010;GO:0032990;GO:0007399;GO:0051726;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:0098792;GO:0006793;GO:0001932;GO:0001934;GO:0048522; protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;membrane organization;plasma membrane organization;signal transduction;cell surface receptor signaling pathway;neuron differentiation;cellular component morphogenesis;cellular component organization or biogenesis;regulation of defense response to virus;cellular response to stimulus;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;regulation of neuron differentiation;cellular developmental process;positive regulation of molecular function;positive regulation of biological process;regulation of immune system process;macromolecule localization;regulation of nervous system development;regulation of macromolecule metabolic process;cell development;regulation of protein kinase activity;dendrite development;positive regulation of JNK cascade;protein localization to membrane;regulation of neuron projection development;response to biotic stimulus;protein localization to plasma membrane;response to other organism;multi-organism process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;response to external stimulus;protein metabolic process;Wnt signaling pathway;immune system process;cellular response to stress;endomembrane system organization;regulation of cell morphogenesis;single-multicellular organism process;cellular component assembly;positive regulation of metabolic process;positive regulation of kinase activity;regulation of multi-organism process;regulation of response to biotic stimulus;neuron projection development;regulation of JNK cascade;intracellular signal transduction;cellular protein metabolic process;regulation of mitotic cell cycle;protein localization to cell periphery;positive regulation of transferase activity;positive regulation of phosphate metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;cellular component organization;regulation of cell projection organization;biological regulation;signal transduction by protein phosphorylation;immune effector process;regulation of molecular function;activation of JNKK activity;positive regulation of catalytic activity;regulation of neurogenesis;regulation of developmental process;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;cell projection morphogenesis;positive regulation of intracellular signal transduction;regulation of defense response;regulation of intracellular signal transduction;cellular protein localization;defense response;response to external biotic stimulus;response to stimulus;regulation of cellular response to stress;response to stress;regulation of transferase activity;neuron projection morphogenesis;regulation of dendrite morphogenesis;response to virus;regulation of immune effector process;positive regulation of phosphorus metabolic process;regulation of multicellular organismal process;regulation of response to external stimulus;phosphorylation;cell differentiation;stress-activated protein kinase signaling cascade;positive regulation of signaling;regulation of MAP kinase activity;signaling;regulation of signaling;positive regulation of cell communication;regulation of cell communication;protein autophosphorylation;single-organism process;regulation of MAPK cascade;cell morphogenesis;JNK cascade;anatomical structure morphogenesis;regulation of anatomical structure morphogenesis;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell development;regulation of cell morphogenesis involved in differentiation;positive regulation of cellular protein metabolic process;regulation of protein modification process;developmental process;multicellular organismal process;regulation of stress-activated protein kinase signaling cascade;macroautophagy;cellular process;positive regulation of stress-activated protein kinase signaling cascade;regulation of stress-activated MAPK cascade;regulation of cell differentiation;defense response to other organism;positive regulation of stress-activated MAPK cascade;single-organism membrane organization;defense response to virus;cell cycle;regulation of cellular protein metabolic process;regulation of dendrite development;dendrite morphogenesis;macromolecule metabolic process;positive regulation of defense response to virus by host;cellular macromolecule localization;cell morphogenesis involved in differentiation;system development;positive regulation of protein kinase activity;regulation of response to stress;activation of MAPKK activity;positive regulation of protein modification process;cell projection organization;cell projection assembly;positive regulation of cellular metabolic process;microvillus assembly;regulation of cellular metabolic process;actin cytoskeleton organization;regulation of JUN kinase activity;single-organism developmental process;cell death;regulation of cell death;multicellular organism development;regulation of cellular component organization;regulation of protein serine/threonine kinase activity;actin cytoskeleton reorganization;regulation of apoptotic process;single-organism organelle organization;regulation of biological process;organic substance metabolic process;regulation of programmed cell death;cellular component biogenesis;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;mitotic cell cycle;actin filament-based process;autophagy;apoptotic process;microvillus organization;cellular protein modification process;regulation of defense response to virus by host;regulation of phosphorus metabolic process;stress-activated MAPK cascade;single-organism cellular process;cell communication;neurogenesis;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;generation of neurons;single-organism cellular localization;cytoskeleton organization;cell part morphogenesis;nervous system development;regulation of cell cycle;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;xenophagy;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 4;6;4;3;3;3;9;4;5;4;5;6;4;2;4;3;4;4;4;5;7;4;4;2;3;3;5;4;4;7;4;8;5;6;3;6;3;2;7;3;7;3;4;6;2;4;4;5;3;4;3;7;3;4;5;7;5;5;5;6;6;6;4;6;3;5;2;4;3;3;8;5;6;3;4;3;3;6;5;5;5;1;2;5;5;5;5;5;4;4;2;4;3;5;6;6;4;4;5;3;4;6;5;5;3;7;2;3;4;4;8;2;6;5;7;3;4;5;5;5;6;5;6;2;2;5;4;2;6;6;4;4;7;4;4;4;5;5;5;4;6;4;5;4;8;4;7;6;4;5;4;6;4;5;8;3;4;4;4;4;8;6;6;4;2;3;5;3;5;6;7;5;4;3;6;5;6;5;5;6;3;4;6;2;3;3;4;3;7;4;5;5;5;4;3;3;5;4;5;4;7;7;3; GO:0031974;GO:0031981;GO:0016020;GO:0016324;GO:0043230;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0098590;GO:0043232;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0005856;GO:0005654;GO:0012505;GO:0031982;GO:0044446;GO:0005773;GO:0044444;GO:0055037;GO:0005737;GO:0005634;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0098805;GO:0045177;GO:0098589;GO:0005886;GO:1903561;GO:0005575;GO:0070013;GO:0005576;GO:0005768; membrane-enclosed lumen;nuclear lumen;membrane;apical plasma membrane;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;membrane part;extracellular region part;organelle part;plasma membrane region;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;cytoskeleton;nucleoplasm;endomembrane system;vesicle;intracellular organelle part;vacuole;cytoplasmic part;recycling endosome;cytoplasm;nucleus;plasma membrane part;cell part;cell;cell periphery;extracellular exosome;whole membrane;apical part of cell;membrane region;plasma membrane;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region;endosome; 2;5;2;4;3;4;3;4;3;2;2;2;4;4;3;3;3;3;2;5;5;3;4;3;5;4;5;4;5;3;2;2;3;4;3;3;3;3;3;1;4;2;4; GO:1901363;GO:0004674;GO:0000166;GO:0016740;GO:0032549;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0017076;GO:0005524;GO:0016301;GO:0003824;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0097159;GO:0036094;GO:0032550;GO:0001882;GO:0001883;GO:0004672;GO:0043168; heterocyclic compound binding;protein serine/threonine kinase activity;nucleotide binding;transferase activity;ribonucleoside binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;purine nucleotide binding;ATP binding;kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;small molecule binding;purine ribonucleoside binding;nucleoside binding;purine nucleoside binding;protein kinase activity;anion binding; 3;7;4;3;5;3;1;2;4;5;6;5;2;5;4;6;5;4;5;3;6;3;3;6;4;5;6;4; K08840 IPR001180;IPR017441;IPR008271;IPR011009;IPR000719; Citron homology (CNH) domain;Protein kinase, ATP binding site;Serine/threonine-protein kinase, active site;Protein kinase-like domain;Protein kinase domain; nucleus Hs22041068 1679.0 T [T] Signal transduction mechanisms; P19652 Alpha-1-acid glycoprotein 2 OS=Homo sapiens OX=9606 GN=ORM2 PE=1 SV=2 - [A1AG2_HUMAN] 1.187 0.803 1.086 1.161 0.811 1.069 1.478206725 2.42E-96 1.431565968 5.01E-87 1.352428394 1.37E-53 1.318125771 2.01E-16 GO:0002376;GO:0050789;GO:0065007;GO:0002682;GO:0006810;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0006954;GO:0002526;GO:0051234;GO:0051179;GO:0050896; immune system process;regulation of biological process;biological regulation;regulation of immune system process;transport;defense response;acute-phase response;response to stress;biological_process;inflammatory response;acute inflammatory response;establishment of localization;localization;response to stimulus; 2;2;2;3;4;4;7;3;1;5;6;3;2;2; GO:0043227;GO:0043226;GO:1903561;GO:0070062;GO:0072562;GO:0031982;GO:0005615;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular vesicle;extracellular exosome;blood microparticle;vesicle;extracellular space;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;3;4;3;4;3;3;1;2;2; K17308 IPR000566;IPR001500;IPR012674; Lipocalin/cytosolic fatty-acid binding domain;Alpha-1-acid glycoprotein;Calycin; extracellular O14976 Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2 - [GAK_HUMAN] 0.849 0.998 1.153 0.74 1.086 2.031 0.850701403 nan 0.681399632 nan 1.155310621 nan 1.870165746 nan GO:0048468;GO:0031345;GO:0031344;GO:0071840;GO:0048869;GO:0010256;GO:0045665;GO:0045664;GO:0010721;GO:0048519;GO:0010977;GO:0010975;GO:0044707;GO:0031175;GO:0050789;GO:0016043;GO:0065007;GO:0007049;GO:0050793;GO:0050794;GO:0008150;GO:0051239;GO:0051961;GO:0051960;GO:0030154;GO:0051129;GO:0051128;GO:0060284;GO:0044699;GO:0050767;GO:0051241;GO:0050768;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0051093;GO:0007030;GO:0048731;GO:0030030;GO:0007275;GO:0048666;GO:0030182;GO:0044767;GO:0044763;GO:0022008;GO:0006996;GO:0048699;GO:0007399;GO:0048856;GO:2000026;GO:0048523; cell development;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;cellular developmental process;endomembrane system organization;negative regulation of neuron differentiation;regulation of neuron differentiation;negative regulation of cell development;negative regulation of biological process;negative regulation of neuron projection development;regulation of neuron projection development;single-multicellular organism process;neuron projection development;regulation of biological process;cellular component organization;biological regulation;cell cycle;regulation of developmental process;regulation of cellular process;biological_process;regulation of multicellular organismal process;negative regulation of nervous system development;regulation of nervous system development;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cell development;single-organism process;regulation of neurogenesis;negative regulation of multicellular organismal process;negative regulation of neurogenesis;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of developmental process;Golgi organization;system development;cell projection organization;multicellular organism development;neuron development;neuron differentiation;single-organism developmental process;single-organism cellular process;neurogenesis;organelle organization;generation of neurons;nervous system development;anatomical structure development;regulation of multicellular organismal development;negative regulation of cellular process; 4;5;5;2;4;4;6;7;5;2;6;6;3;5;2;3;2;4;3;3;1;3;4;5;5;4;4;5;2;6;3;5;2;2;2;4;4;3;5;4;4;4;5;6;3;3;6;4;7;5;3;4;3; GO:0030055;GO:0031982;GO:0016020;GO:0005794;GO:0043231;GO:0030054;GO:0044424;GO:0043229;GO:0005924;GO:0005925;GO:0043227;GO:0048471;GO:0070161;GO:0012505;GO:0005737;GO:0005912;GO:0044464;GO:0005623;GO:0005622;GO:0044444;GO:0043226;GO:0005575; cell-substrate junction;vesicle;membrane;Golgi apparatus;intracellular membrane-bounded organelle;cell junction;intracellular part;intracellular organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;perinuclear region of cytoplasm;anchoring junction;endomembrane system;cytoplasm;adherens junction;cell part;cell;intracellular;cytoplasmic part;organelle;cellular_component; 3;4;2;4;4;2;3;3;4;5;3;5;3;3;4;4;2;2;3;4;2;1; GO:0000166;GO:0016740;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0016301;GO:0003824;GO:0036094;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0097159;GO:0001883;GO:0001882;GO:0004674;GO:0004672; nucleotide binding;transferase activity;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;kinase activity;catalytic activity;small molecule binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;protein serine/threonine kinase activity;protein kinase activity; 4;3;3;1;2;4;3;5;5;6;4;5;2;3;5;4;6;5;6;4;5;3;6;3;5;4;7;6; K08855 IPR011009;IPR000719;IPR029021;IPR029023;IPR008271;IPR014020;IPR001623;IPR000008; Protein kinase-like domain;Protein kinase domain;Protein-tyrosine phosphatase-like;Tensin-type phosphatase domain;Serine/threonine-protein kinase, active site;Tensin phosphatase, C2 domain;DnaJ domain;C2 domain; plasma membrane Hs4885251_2 1409.0 TR [T] Signal transduction mechanisms;[R] General function prediction only; Q6P1Q0 LETM1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LETMD1 PE=1 SV=1 - [LTMD1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0031975;GO:0043229;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0005575;GO:0031090;GO:0098805;GO:0016020;GO:0005740;GO:0005739;GO:0031968;GO:0098588;GO:0031967;GO:0031966;GO:0043231;GO:0044464;GO:0019867;GO:0005623;GO:0005622;GO:0044446;GO:0044444;GO:0005741;GO:0044429;GO:0044424;GO:0044425;GO:0016021;GO:0044422; envelope;intracellular organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;cellular_component;organelle membrane;whole membrane;membrane;mitochondrial envelope;mitochondrion;organelle outer membrane;bounding membrane of organelle;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;cell part;outer membrane;cell;intracellular;intracellular organelle part;cytoplasmic part;mitochondrial outer membrane;mitochondrial part;intracellular part;membrane part;integral component of membrane;organelle part; 3;3;3;2;3;4;1;3;3;2;5;5;4;4;4;4;4;2;3;2;3;3;4;5;4;3;2;4;2; GO:0003674;GO:0005488;GO:0043021;GO:0043022;GO:0044877; molecular_function;binding;ribonucleoprotein complex binding;ribosome binding;macromolecular complex binding; 1;2;4;5;3; IPR033122;IPR011685; Letm1 ribosome-binding domain;LETM1-like; mitochondria Hs21166357 743.0 T [T] Signal transduction mechanisms; P49848 Transcription initiation factor TFIID subunit 6 OS=Homo sapiens OX=9606 GN=TAF6 PE=1 SV=1 - [TAF6_HUMAN] 0.906 0.888 1.423 0.943 0.962 0.915 1.02027027 nan 0.98024948 nan 1.602477477 nan 0.951143451 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0045786;GO:0044419;GO:0048519;GO:0051704;GO:0042127;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0007049;GO:0006367;GO:0006366;GO:0006368;GO:0065009;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0006352;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0008285;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0044764;GO:0051090;GO:0051252;GO:0043170;GO:0031326;GO:0031323;GO:0090304;GO:0006354;GO:2000112;GO:0071704;GO:0010467;GO:0010468;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0044238;GO:0051726;GO:0044237;GO:0016032;GO:0044403;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of cell cycle;interspecies interaction between organisms;negative regulation of biological process;multi-organism process;regulation of cell proliferation;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;cell cycle;transcription initiation from RNA polymerase II promoter;transcription from RNA polymerase II promoter;transcription elongation from RNA polymerase II promoter;regulation of molecular function;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;negative regulation of cell proliferation;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;multi-organism cellular process;regulation of sequence-specific DNA binding transcription factor activity;regulation of RNA metabolic process;macromolecule metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;DNA-templated transcription, elongation;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;primary metabolic process;regulation of cell cycle;cellular metabolic process;viral process;symbiosis, encompassing mutualism through parasitism;negative regulation of cellular process; 4;3;5;4;4;3;2;2;4;4;6;4;5;3;2;7;4;4;2;4;8;7;8;3;5;4;3;1;2;5;5;5;6;5;6;7;6;4;4;5;2;4;4;3;2;4;7;3;4;5;4;5;4;5;7;6;3;5;5;5;3;5;3;4;3;4;3;4;4;3; GO:0031974;GO:0016591;GO:0030880;GO:0031981;GO:0044798;GO:0071339;GO:1902493;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0090575;GO:0044428;GO:0005667;GO:0044424;GO:0044422;GO:0031248;GO:0000428;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0055029;GO:0005669;GO:0035097;GO:0044446;GO:0005737;GO:0000123;GO:0005634;GO:0033276;GO:0044451;GO:0044464;GO:0005623;GO:0070461;GO:0044665;GO:0061695;GO:0043226;GO:0034708;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;DNA-directed RNA polymerase II, holoenzyme;RNA polymerase complex;nuclear lumen;nuclear transcription factor complex;MLL1 complex;acetyltransferase complex;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;RNA polymerase II transcription factor complex;nuclear part;transcription factor complex;intracellular part;organelle part;protein acetyltransferase complex;DNA-directed RNA polymerase complex;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;nuclear DNA-directed RNA polymerase complex;transcription factor TFIID complex;histone methyltransferase complex;intracellular organelle part;cytoplasm;histone acetyltransferase complex;nucleus;transcription factor TFTC complex;nucleoplasm part;cell part;cell;SAGA-type complex;MLL1/2 complex;transferase complex, transferring phosphorus-containing groups;organelle;methyltransferase complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;6;4;5;5;7;6;4;5;3;4;3;6;4;4;3;2;4;5;3;3;3;5;5;6;5;3;4;5;5;7;5;2;2;6;6;6;2;4;2;1;4; GO:0001071;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;transcription factor activity, sequence-specific DNA binding; 2;3;1;2;4;5;3;3; K03131 map03022;map05168; Basal transcription factors;Herpes simplex infection; IPR016024;IPR011989;IPR011442;IPR009072;IPR004823; Armadillo-type fold;Armadillo-like helical;TAF6, C-terminal HEAT repeat domain;Histone-fold;TATA box binding protein associated factor (TAF); nucleus Hs5032147 1373.0 K [K] Transcription; A6NMZ7 Collagen alpha-6(VI) chain OS=Homo sapiens OX=9606 GN=COL6A6 PE=1 SV=2 - [CO6A6_HUMAN] 0.814 0.523 2.145 0.731 0.671 1.049 1.556405354 nan 1.089418778 nan 4.101338432 nan 1.563338301 nan GO:0008152;GO:0032963;GO:0043170;GO:0044699;GO:0044712;GO:0044710;GO:0044243;GO:0016043;GO:0071704;GO:0030198;GO:0071840;GO:0043062;GO:0022610;GO:0022617;GO:0032501;GO:0009987;GO:0008150;GO:0044259;GO:0007155;GO:0009056;GO:0044707;GO:0030574;GO:0044236;GO:0044763;GO:0022411; metabolic process;collagen metabolic process;macromolecule metabolic process;single-organism process;single-organism catabolic process;single-organism metabolic process;multicellular organism catabolic process;cellular component organization;organic substance metabolic process;extracellular matrix organization;cellular component organization or biogenesis;extracellular structure organization;biological adhesion;extracellular matrix disassembly;multicellular organismal process;cellular process;biological_process;multicellular organismal macromolecule metabolic process;cell adhesion;catabolic process;single-multicellular organism process;collagen catabolic process;multicellular organism metabolic process;single-organism cellular process;cellular component disassembly; 2;6;4;2;4;3;5;3;3;5;2;4;2;5;2;2;1;5;3;3;3;5;4;3;4; GO:0031012;GO:0005581;GO:0043234;GO:0032991;GO:0005578;GO:0005575;GO:0005576;GO:0044421; extracellular matrix;collagen trimer;protein complex;macromolecular complex;proteinaceous extracellular matrix;cellular_component;extracellular region;extracellular region part; 2;4;3;2;3;1;2;2; K06238 map04151;map04510;map04512;map04974; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Protein digestion and absorption; IPR008160;IPR002035; Collagen triple helix repeat;von Willebrand factor, type A; endoplasmic reticulum Hs22043058 1632.0 W [W] Extracellular structures; Q6PIJ6 F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3 - [FBX38_HUMAN] 1.178 1.005 1.057 0.914 1.114 0.551 1.172139303 0.264383344 0.820466786 0.016875507 1.051741294 0.540307929 0.494614004 0.000990736 GO:0048666;GO:0044707;GO:0051239;GO:0030030;GO:0030154;GO:0048468;GO:0007275;GO:0051128;GO:0050789;GO:0060284;GO:0031175;GO:0031344;GO:0044699;GO:0031346;GO:0050767;GO:0048869;GO:0016043;GO:0050769;GO:0045664;GO:0045666;GO:0065007;GO:0071840;GO:0010720;GO:0048518;GO:0032502;GO:0032501;GO:0030182;GO:0050793;GO:0009987;GO:0050794;GO:0044767;GO:0045595;GO:0008150;GO:0010976;GO:0010975;GO:0048731;GO:0022008;GO:0045597;GO:0048699;GO:0007399;GO:0051094;GO:0048856;GO:0051962;GO:0051960;GO:2000026;GO:0044763;GO:0051130;GO:0051240;GO:0048522; neuron development;single-multicellular organism process;regulation of multicellular organismal process;cell projection organization;cell differentiation;cell development;multicellular organism development;regulation of cellular component organization;regulation of biological process;regulation of cell development;neuron projection development;regulation of cell projection organization;single-organism process;positive regulation of cell projection organization;regulation of neurogenesis;cellular developmental process;cellular component organization;positive regulation of neurogenesis;regulation of neuron differentiation;positive regulation of neuron differentiation;biological regulation;cellular component organization or biogenesis;positive regulation of cell development;positive regulation of biological process;developmental process;multicellular organismal process;neuron differentiation;regulation of developmental process;cellular process;regulation of cellular process;single-organism developmental process;regulation of cell differentiation;biological_process;positive regulation of neuron projection development;regulation of neuron projection development;system development;neurogenesis;positive regulation of cell differentiation;generation of neurons;nervous system development;positive regulation of developmental process;anatomical structure development;positive regulation of nervous system development;regulation of nervous system development;regulation of multicellular organismal development;single-organism cellular process;positive regulation of cellular component organization;positive regulation of multicellular organismal process;positive regulation of cellular process; 5;3;3;4;5;4;4;4;2;5;5;5;2;5;6;4;3;5;7;6;2;2;5;2;2;2;6;3;2;3;3;4;1;6;6;4;6;4;7;5;3;3;4;5;4;3;4;3;3; GO:0043226;GO:0043229;GO:0043227;GO:0005737;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; organelle;intracellular organelle;membrane-bounded organelle;cytoplasm;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 2;3;3;4;5;4;2;2;3;1;3; K10313 IPR032675;IPR001810; Leucine-rich repeat domain, L domain-like;F-box domain; nucleus P27918 Properdin OS=Homo sapiens OX=9606 GN=CFP PE=1 SV=2 - [PROP_HUMAN] 0.923 0.924 1.458 0.798 0.963 1.221 0.998917749 0.41826923 0.828660436 0.284119332 1.577922078 0.002976762 1.267912773 0.152936552 GO:0019222;GO:0048584;GO:0048583;GO:0031347;GO:0080090;GO:0044710;GO:0043207;GO:0009617;GO:0009611;GO:0048518;GO:0065007;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0051707;GO:0051704;GO:0009607;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0042742;GO:0043170;GO:0050789;GO:0036065;GO:0044267;GO:0036066;GO:0044260;GO:0002684;GO:0002682;GO:0006952;GO:0006950;GO:0036211;GO:0006956;GO:0006957;GO:0008152;GO:0006955;GO:0044723;GO:0002526;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0043412;GO:0043413;GO:0008150;GO:1903317;GO:0006954;GO:0032101;GO:0050727;GO:0044249;GO:0034645;GO:0044699;GO:0051246;GO:0006508;GO:1903034;GO:0043687;GO:0009987;GO:0098542;GO:0016485;GO:0006493;GO:0050776;GO:1901137;GO:1901135;GO:0050778;GO:0080134;GO:0009100;GO:0009101;GO:0006486;GO:0072376;GO:0002697;GO:0071704;GO:0010467;GO:0010468;GO:1901576;GO:0045087;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0044238;GO:0005975;GO:0044237;GO:0002253;GO:0002252; regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;regulation of defense response;regulation of primary metabolic process;single-organism metabolic process;response to external biotic stimulus;response to bacterium;response to wounding;positive regulation of biological process;biological regulation;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;response to other organism;multi-organism process;response to biotic stimulus;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;defense response to bacterium;macromolecule metabolic process;regulation of biological process;fucosylation;cellular protein metabolic process;protein O-linked fucosylation;cellular macromolecule metabolic process;positive regulation of immune system process;regulation of immune system process;defense response;response to stress;protein modification process;complement activation;complement activation, alternative pathway;metabolic process;immune response;single-organism carbohydrate metabolic process;acute inflammatory response;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;macromolecule modification;macromolecule glycosylation;biological_process;regulation of protein maturation;inflammatory response;regulation of response to external stimulus;regulation of inflammatory response;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;regulation of protein metabolic process;proteolysis;regulation of response to wounding;post-translational protein modification;cellular process;defense response to other organism;protein processing;protein O-linked glycosylation;regulation of immune response;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;positive regulation of immune response;regulation of response to stress;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein activation cascade;regulation of immune effector process;organic substance metabolic process;gene expression;regulation of gene expression;organic substance biosynthetic process;innate immune response;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;primary metabolic process;carbohydrate metabolic process;cellular metabolic process;activation of immune response;immune effector process; 3;3;3;5;4;3;4;4;4;2;2;4;4;6;6;3;2;3;3;4;2;5;5;5;4;2;6;5;6;4;3;3;4;3;5;4;5;2;3;4;6;4;7;5;2;5;6;1;6;5;4;5;4;5;2;5;5;5;7;2;4;6;5;4;5;4;4;4;5;6;4;3;4;3;5;5;4;4;5;6;3;5;3;3;4;3;3;3; GO:0005783;GO:0031974;GO:0005788;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0044446;GO:0044444;GO:0012505;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005615;GO:0043226;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;membrane-enclosed lumen;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;intracellular organelle part;cytoplasmic part;endomembrane system;cytoplasm;cell part;cell;intracellular;extracellular space;organelle;cellular_component;intracellular organelle lumen;extracellular region; 4;2;5;4;3;3;2;2;3;3;4;3;4;3;4;2;2;3;3;2;1;4;2; K15412 map05168; Herpes simplex infection; IPR000884; Thrombospondin type-1 (TSP1) repeat; extracellular Hs4505737 930.0 RP [R] General function prediction only;[P] Inorganic ion transport and metabolism; P07942 Laminin subunit beta-1 OS=Homo sapiens OX=9606 GN=LAMB1 PE=1 SV=2 - [LAMB1_HUMAN] 0.954 1.715 0.245 2.099 0.654 0.739 0.556268222 nan 3.209480122 nan 0.142857143 nan 1.129969419 nan GO:0034446;GO:0048468;GO:0060322;GO:0032989;GO:0071840;GO:0042330;GO:0048869;GO:0007369;GO:0048513;GO:0048518;GO:0042127;GO:0031589;GO:0006935;GO:0097485;GO:0022029;GO:0050679;GO:0044707;GO:0009605;GO:0048870;GO:0030198;GO:0021537;GO:0048598;GO:0022030;GO:0006928;GO:0051674;GO:0031175;GO:0050673;GO:0050789;GO:0000904;GO:0000902;GO:0016043;GO:0065007;GO:0016477;GO:0048646;GO:0009887;GO:0098602;GO:0061564;GO:0021812;GO:0098609;GO:0042063;GO:0050794;GO:0021543;GO:0008150;GO:0035987;GO:0007420;GO:0050896;GO:0048812;GO:2000145;GO:2000147;GO:0022411;GO:0007492;GO:0030154;GO:0009790;GO:0021885;GO:0007411;GO:0009653;GO:0044699;GO:0007417;GO:0001706;GO:0001704;GO:0021799;GO:0022610;GO:0022617;GO:0021795;GO:0032502;GO:0032501;GO:0009987;GO:0051270;GO:0007409;GO:0021987;GO:0032879;GO:0032990;GO:0050678;GO:0007399;GO:0048731;GO:0021801;GO:0008284;GO:0016337;GO:0030030;GO:0007275;GO:0009888;GO:0008283;GO:0043062;GO:0048666;GO:0048667;GO:0030335;GO:0030334;GO:0030182;GO:0044767;GO:0044763;GO:0007155;GO:0042221;GO:0022008;GO:0051179;GO:0008347;GO:0040011;GO:0051272;GO:0048699;GO:0040012;GO:0048858;GO:0040017;GO:0042476;GO:0048856;GO:0030900;GO:0048522; substrate adhesion-dependent cell spreading;cell development;head development;cellular component morphogenesis;cellular component organization or biogenesis;taxis;cellular developmental process;gastrulation;animal organ development;positive regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;chemotaxis;neuron projection guidance;telencephalon cell migration;positive regulation of epithelial cell proliferation;single-multicellular organism process;response to external stimulus;cell motility;extracellular matrix organization;telencephalon development;embryonic morphogenesis;telencephalon glial cell migration;movement of cell or subcellular component;localization of cell;neuron projection development;epithelial cell proliferation;regulation of biological process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;biological regulation;cell migration;anatomical structure formation involved in morphogenesis;organ morphogenesis;single organism cell adhesion;axon development;neuronal-glial interaction involved in cerebral cortex radial glia guided migration;cell-cell adhesion;gliogenesis;regulation of cellular process;pallium development;biological_process;endodermal cell differentiation;brain development;response to stimulus;neuron projection morphogenesis;regulation of cell motility;positive regulation of cell motility;cellular component disassembly;endoderm development;cell differentiation;embryo development;forebrain cell migration;axon guidance;anatomical structure morphogenesis;single-organism process;central nervous system development;endoderm formation;formation of primary germ layer;cerebral cortex radially oriented cell migration;biological adhesion;extracellular matrix disassembly;cerebral cortex cell migration;developmental process;multicellular organismal process;cellular process;regulation of cellular component movement;axonogenesis;cerebral cortex development;regulation of localization;cell part morphogenesis;regulation of epithelial cell proliferation;nervous system development;system development;cerebral cortex radial glia guided migration;positive regulation of cell proliferation;single organismal cell-cell adhesion;cell projection organization;multicellular organism development;tissue development;cell proliferation;extracellular structure organization;neuron development;cell morphogenesis involved in neuron differentiation;positive regulation of cell migration;regulation of cell migration;neuron differentiation;single-organism developmental process;single-organism cellular process;cell adhesion;response to chemical;neurogenesis;localization;glial cell migration;locomotion;positive regulation of cellular component movement;generation of neurons;regulation of locomotion;cell projection morphogenesis;positive regulation of locomotion;odontogenesis;anatomical structure development;forebrain development;positive regulation of cellular process; 4;4;4;4;2;3;4;5;4;2;4;4;4;5;5;5;3;3;3;5;4;4;6;4;3;5;4;2;5;5;3;2;4;3;4;3;6;5;4;7;3;4;1;6;4;2;6;4;4;4;5;5;5;5;6;3;2;5;5;4;6;2;5;5;2;2;2;4;7;4;3;5;5;5;4;7;4;4;4;4;4;3;4;5;6;5;5;6;3;3;3;3;6;2;5;2;4;7;3;5;3;5;3;4;3; GO:0031982;GO:0043234;GO:0043230;GO:0044424;GO:0044420;GO:0044421;GO:0043227;GO:0048471;GO:0043259;GO:0043256;GO:0043257;GO:0044444;GO:0031012;GO:0043226;GO:0005737;GO:0005607;GO:0005606;GO:0005605;GO:0044464;GO:0005623;GO:0005622;GO:0005604;GO:0005615;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576;GO:0005578; vesicle;protein complex;extracellular organelle;intracellular part;extracellular matrix component;extracellular region part;membrane-bounded organelle;perinuclear region of cytoplasm;laminin-10 complex;laminin complex;laminin-8 complex;cytoplasmic part;extracellular matrix;organelle;cytoplasm;laminin-2 complex;laminin-1 complex;basal lamina;cell part;cell;intracellular;basement membrane;extracellular space;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region;proteinaceous extracellular matrix; 4;3;3;3;2;2;3;5;4;3;4;4;2;2;4;4;4;3;2;2;3;3;3;3;4;2;1;2;3; GO:0003674;GO:0005201;GO:0005198; molecular_function;extracellular matrix structural constituent;structural molecule activity; 1;3;2; K05636 map04151;map04510;map04512;map05145;map05146;map05200;map05222; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer; IPR013015;IPR008979;IPR000742;IPR002049;IPR008211; Laminin IV type B;Galactose-binding domain-like;EGF-like domain;Laminin EGF domain;Laminin, N-terminal; extracellular Hs4504951 3704.0 W [W] Extracellular structures; Q9BXT8 RING finger protein 17 OS=Homo sapiens OX=9606 GN=RNF17 PE=1 SV=3 - [RNF17_HUMAN] 1.098 1.012 0.988 1.081 0.937 1.304 1.084980237 nan 1.153681964 nan 0.976284585 nan 1.39167556 nan GO:0030154;GO:0048468;GO:0019953;GO:0007276;GO:0000003;GO:0048869;GO:0048515;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0009987;GO:0044703;GO:0007281;GO:0022414;GO:0007283;GO:0008150;GO:0022412;GO:0048232;GO:0051704;GO:0044767;GO:0044699;GO:0044702;GO:0044707;GO:0003006;GO:0048856;GO:0007275;GO:0044763;GO:0007286; cell differentiation;cell development;sexual reproduction;gamete generation;reproduction;cellular developmental process;spermatid differentiation;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cellular process;multi-organism reproductive process;germ cell development;reproductive process;spermatogenesis;biological_process;cellular process involved in reproduction in multicellular organism;male gamete generation;multi-organism process;single-organism developmental process;single-organism process;single organism reproductive process;single-multicellular organism process;developmental process involved in reproduction;anatomical structure development;multicellular organism development;single-organism cellular process;spermatid development; 5;4;3;4;2;4;4;2;2;3;3;2;3;4;2;6;1;4;5;2;3;2;3;3;3;3;4;3;5; GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;4;5;4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0043169;GO:0046914;GO:0043167;GO:0046872;GO:0008270; molecular_function;binding;cation binding;transition metal ion binding;ion binding;metal ion binding;zinc ion binding; 1;2;4;6;3;5;7; K18405 IPR035437;IPR001841;IPR013083;IPR016071;IPR002999;IPR017907; Staphylococcal nuclease (SNase-like), OB-fold/extended TUDOR domain;Zinc finger, RING-type;Zinc finger, RING/FYVE/PHD-type;Staphylococcal nuclease (SNase-like), OB-fold;Tudor domain;Zinc finger, RING-type, conserved site; nucleus Q9HCL3 Zinc finger protein 14 homolog OS=Homo sapiens OX=9606 GN=ZFP14 PE=2 SV=2 - [ZFP14_HUMAN] 1.068 0.841 0.949 1.196 1.036 1.482 1.269916766 nan 1.154440154 nan 1.128418549 nan 1.430501931 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:0043170;GO:1901360;GO:0032774;GO:1901576;GO:0044260;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0060255;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0051252;GO:0006355;GO:0010556;GO:0006351;GO:0019438;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of macromolecule metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of RNA metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process; 4;3;5;4;5;4;4;3;5;4;4;6;4;4;5;6;2;3;5;2;7;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;5;6;5;6;5;3; GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 3;2;5;4;2;3;2;3;1;3; GO:0043169;GO:0003674;GO:0001071;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0003700;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;nucleic acid binding transcription factor activity;DNA binding;metal ion binding;nucleic acid binding;ion binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;2;5;5;4;3;3;3;3;2; K09228 IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs20545014 1089.0 R [R] General function prediction only; Q9NZ38 Uncharacterized protein IDI2-AS1 OS=Homo sapiens OX=9606 GN=IDI2-AS1 PE=2 SV=1 - [IDAS1_HUMAN] 0.706 0.565 2.13 0.77 0.607 0.945 1.249557522 0.590004445 1.268533773 0.337757532 3.769911504 0.062305758 1.556836903 0.330421857 extracellular P09486 SPARC OS=Homo sapiens OX=9606 GN=SPARC PE=1 SV=1 - [SPRC_HUMAN] 1.015 1.003 0.965 1.064 1.096 1.1 1.011964108 0.995816083 0.97080292 0.503070653 0.962113659 0.913928242 1.003649635 0.961565719 GO:0007599;GO:0001667;GO:0007596;GO:0050680;GO:0001501;GO:0072359;GO:0001503;GO:0007165;GO:0071840;GO:0051716;GO:0043207;GO:0048869;GO:0009617;GO:0009611;GO:0048513;GO:0048514;GO:0048518;GO:0048519;GO:0060541;GO:0031960;GO:0051592;GO:0051591;GO:0010038;GO:0050678;GO:0043434;GO:0010035;GO:0051707;GO:0010033;GO:0030168;GO:0051704;GO:0010634;GO:0044700;GO:0009607;GO:0044707;GO:0009605;GO:0010243;GO:0034284;GO:0031667;GO:0030198;GO:0022604;GO:0022603;GO:0006928;GO:0010594;GO:0051674;GO:0072358;GO:0032496;GO:0050673;GO:0050789;GO:0043542;GO:0000902;GO:0001568;GO:0006887;GO:0016043;GO:0045055;GO:0065007;GO:0044699;GO:0065008;GO:0048646;GO:0034097;GO:0050793;GO:0006810;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0007507;GO:0051234;GO:0046903;GO:0006897;GO:0007423;GO:0050896;GO:0006898;GO:0001775;GO:2000145;GO:2000147;GO:0016525;GO:0097305;GO:0051240;GO:0051239;GO:0033591;GO:0051128;GO:0030323;GO:0023052;GO:0070887;GO:0042221;GO:2000181;GO:0014074;GO:0009653;GO:0070848;GO:0014070;GO:0010631;GO:0009719;GO:0051241;GO:0001944;GO:0033273;GO:0010632;GO:0032502;GO:0040011;GO:0032501;GO:0010288;GO:0050878;GO:0009628;GO:0009987;GO:0001101;GO:0032879;GO:0090132;GO:0090130;GO:0051093;GO:0048839;GO:0071363;GO:1901342;GO:0009725;GO:0032940;GO:1901343;GO:0002237;GO:0048731;GO:1901698;GO:0048545;GO:0042127;GO:0009991;GO:0051384;GO:0030324;GO:0008285;GO:0048870;GO:0060348;GO:0016477;GO:0001525;GO:0007275;GO:0033993;GO:0008283;GO:0045765;GO:0032989;GO:0071310;GO:0040012;GO:0043583;GO:0043062;GO:0046686;GO:2000026;GO:0046683;GO:0030335;GO:0030334;GO:0009629;GO:0007584;GO:0044767;GO:0045471;GO:0044765;GO:0044763;GO:0007154;GO:0035295;GO:0051179;GO:1902578;GO:1901700;GO:0051272;GO:0051270;GO:0010595;GO:0009743;GO:0040017;GO:0001936;GO:0048856;GO:1901652;GO:0001937;GO:0048522;GO:0001935;GO:0002576;GO:0048523;GO:0016192; hemostasis;ameboidal-type cell migration;blood coagulation;negative regulation of epithelial cell proliferation;skeletal system development;circulatory system development;ossification;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;response to external biotic stimulus;cellular developmental process;response to bacterium;response to wounding;animal organ development;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;respiratory system development;response to corticosteroid;response to calcium ion;response to cAMP;response to metal ion;regulation of epithelial cell proliferation;response to peptide hormone;response to inorganic substance;response to other organism;response to organic substance;platelet activation;multi-organism process;positive regulation of epithelial cell migration;single organism signaling;response to biotic stimulus;single-multicellular organism process;response to external stimulus;response to organonitrogen compound;response to monosaccharide;response to nutrient levels;extracellular matrix organization;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;regulation of endothelial cell migration;localization of cell;cardiovascular system development;response to lipopolysaccharide;epithelial cell proliferation;regulation of biological process;endothelial cell migration;cell morphogenesis;blood vessel development;exocytosis;cellular component organization;regulated exocytosis;biological regulation;single-organism process;regulation of biological quality;anatomical structure formation involved in morphogenesis;response to cytokine;regulation of developmental process;transport;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;heart development;establishment of localization;secretion;endocytosis;sensory organ development;response to stimulus;receptor-mediated endocytosis;cell activation;regulation of cell motility;positive regulation of cell motility;negative regulation of angiogenesis;response to alcohol;positive regulation of multicellular organismal process;regulation of multicellular organismal process;response to L-ascorbic acid;regulation of cellular component organization;respiratory tube development;signaling;cellular response to chemical stimulus;response to chemical;negative regulation of blood vessel morphogenesis;response to purine-containing compound;anatomical structure morphogenesis;response to growth factor;response to organic cyclic compound;epithelial cell migration;response to endogenous stimulus;negative regulation of multicellular organismal process;vasculature development;response to vitamin;regulation of epithelial cell migration;developmental process;locomotion;multicellular organismal process;response to lead ion;regulation of body fluid levels;response to abiotic stimulus;cellular process;response to acid chemical;regulation of localization;epithelium migration;tissue migration;negative regulation of developmental process;inner ear development;cellular response to growth factor stimulus;regulation of vasculature development;response to hormone;secretion by cell;negative regulation of vasculature development;response to molecule of bacterial origin;system development;response to nitrogen compound;response to steroid hormone;regulation of cell proliferation;response to extracellular stimulus;response to glucocorticoid;lung development;negative regulation of cell proliferation;cell motility;bone development;cell migration;angiogenesis;multicellular organism development;response to lipid;cell proliferation;regulation of angiogenesis;cellular component morphogenesis;cellular response to organic substance;regulation of locomotion;ear development;extracellular structure organization;response to cadmium ion;regulation of multicellular organismal development;response to organophosphorus;positive regulation of cell migration;regulation of cell migration;response to gravity;response to nutrient;single-organism developmental process;response to ethanol;single-organism transport;single-organism cellular process;cell communication;tube development;localization;single-organism localization;response to oxygen-containing compound;positive regulation of cellular component movement;regulation of cellular component movement;positive regulation of endothelial cell migration;response to carbohydrate;positive regulation of locomotion;regulation of endothelial cell proliferation;anatomical structure development;response to peptide;negative regulation of endothelial cell proliferation;positive regulation of cellular process;endothelial cell proliferation;platelet degranulation;negative regulation of cellular process;vesicle-mediated transport; 5;5;5;5;5;5;4;4;2;3;4;4;4;4;4;4;2;2;5;6;6;5;5;5;5;4;3;4;5;2;4;3;3;3;3;4;6;5;5;5;4;4;5;3;5;5;4;2;7;5;4;5;3;6;2;2;3;3;5;3;4;5;3;3;4;1;4;3;5;6;4;2;7;4;4;4;5;5;3;3;5;4;4;2;4;3;5;5;3;5;5;6;3;3;5;5;4;2;2;2;6;4;3;2;4;3;5;4;3;4;6;5;4;4;4;5;4;4;5;4;4;7;4;4;3;4;4;4;4;5;3;5;4;5;3;5;4;6;4;5;5;5;4;4;3;6;4;3;4;4;2;3;4;4;4;5;5;3;6;3;5;6;3;5;7;3;5; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0099503;GO:0098588;GO:0034774;GO:0016363;GO:0043233;GO:0043231;GO:0044428;GO:0044424;GO:0031012;GO:0044420;GO:0044421;GO:0044422;GO:0060205;GO:0043229;GO:0043227;GO:0044433;GO:0005737;GO:0030141;GO:0012505;GO:0012506;GO:0071682;GO:0044446;GO:0044444;GO:0097708;GO:0016020;GO:0043226;GO:0030667;GO:0031091;GO:0031090;GO:0031093;GO:0031092;GO:0031410;GO:0005634;GO:0009986;GO:0030659;GO:0031981;GO:0005578;GO:0044464;GO:0005623;GO:0005622;GO:0005604;GO:0030139;GO:0005615;GO:0098805;GO:0034399;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;secretory vesicle;bounding membrane of organelle;secretory granule lumen;nuclear matrix;organelle lumen;intracellular membrane-bounded organelle;nuclear part;intracellular part;extracellular matrix;extracellular matrix component;extracellular region part;organelle part;cytoplasmic membrane-bounded vesicle lumen;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;cytoplasm;secretory granule;endomembrane system;vesicle membrane;endocytic vesicle lumen;intracellular organelle part;cytoplasmic part;intracellular vesicle;membrane;organelle;secretory granule membrane;platelet alpha granule;organelle membrane;platelet alpha granule lumen;platelet alpha granule membrane;cytoplasmic vesicle;nucleus;cell surface;cytoplasmic vesicle membrane;nuclear lumen;proteinaceous extracellular matrix;cell part;cell;intracellular;basement membrane;endocytic vesicle;extracellular space;whole membrane;nuclear periphery;cellular_component;intracellular organelle lumen;extracellular region; 2;4;4;5;5;6;4;5;5;3;4;4;3;2;2;2;2;5;3;3;4;4;4;3;4;6;3;4;4;2;2;4;5;3;6;5;5;5;3;5;5;3;2;2;3;3;6;3;3;5;1;4;2; GO:0050840;GO:0046872;GO:0044877;GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0032403;GO:0005515;GO:0005518; extracellular matrix binding;metal ion binding;macromolecular complex binding;molecular_function;binding;cation binding;ion binding;calcium ion binding;protein complex binding;protein binding;collagen binding; 3;5;3;1;2;4;3;6;4;3;5; IPR003645;IPR018247;IPR015369;IPR011992;IPR001999;IPR002350;IPR019577; Follistatin-like, N-terminal;EF-Hand 1, calcium-binding site;Follistatin/Osteonectin EGF domain;EF-hand domain pair;Osteonectin-like, conserved site;Kazal domain;SPARC/Testican, calcium-binding domain; extracellular Hs4507171 629.0 W [W] Extracellular structures; O00468 Agrin OS=Homo sapiens OX=9606 GN=AGRN PE=1 SV=6 - [AGRIN_HUMAN] 0.481 0.692 2.157 0.868 0.64 0.701 0.695086705 0.533192808 1.35625 0.405614056 3.117052023 0.123511398 1.0953125 0.790334957 GO:1901566;GO:0006775;GO:0080090;GO:0048589;GO:0001523;GO:0008582;GO:0048469;GO:0051173;GO:0061024;GO:0051124;GO:0044281;GO:1905145;GO:0010556;GO:0032989;GO:1901362;GO:0031344;GO:0071840;GO:0031346;GO:0044710;GO:0097485;GO:0042330;GO:0070727;GO:0048869;GO:0008104;GO:0044711;GO:0019438;GO:0044093;GO:0048518;GO:0016101;GO:0098926;GO:0006935;GO:0060255;GO:0048468;GO:0043062;GO:0007603;GO:0007602;GO:0007528;GO:0072657;GO:2001141;GO:0043436;GO:0051128;GO:0009628;GO:0010033;GO:0044700;GO:1901564;GO:0009605;GO:0044707;GO:0019538;GO:0051668;GO:0006355;GO:0060491;GO:0051345;GO:0030198;GO:0046847;GO:0007165;GO:0043547;GO:0030204;GO:0030203;GO:0034645;GO:0009581;GO:0006023;GO:0006928;GO:1901137;GO:0006807;GO:0031175;GO:0045935;GO:0009057;GO:0050789;GO:0097659;GO:1901576;GO:1901575;GO:0000904;GO:0000902;GO:0044260;GO:0042551;GO:0046483;GO:0016043;GO:0065007;GO:0044699;GO:0045893;GO:0006366;GO:0065009;GO:0065008;GO:0007186;GO:0018130;GO:0051130;GO:0043085;GO:0061564;GO:0006629;GO:0006139;GO:0050793;GO:0050790;GO:0009889;GO:0051716;GO:0050794;GO:1903831;GO:1905144;GO:0008150;GO:0008152;GO:0095500;GO:0034654;GO:0010604;GO:0051336;GO:0051606;GO:0045161;GO:0050896;GO:1901699;GO:0050654;GO:0051962;GO:0006029;GO:0009416;GO:0051965;GO:0007213;GO:0006022;GO:0044802;GO:0006026;GO:0006027;GO:0099536;GO:1901565;GO:0048639;GO:0048638;GO:0050808;GO:0051239;GO:0050803;GO:0009314;GO:0030154;GO:0050807;GO:0016070;GO:0071242;GO:0044249;GO:0034641;GO:0022607;GO:0023052;GO:0051491;GO:0070887;GO:0007154;GO:0007411;GO:0009653;GO:0043087;GO:1902580;GO:0007416;GO:0009893;GO:1904396;GO:1904398;GO:0051240;GO:0009891;GO:0031326;GO:0051641;GO:0044271;GO:0031325;GO:0032502;GO:1901700;GO:0032501;GO:1901701;GO:0006721;GO:0006720;GO:0009987;GO:0006725;GO:1903506;GO:0051489;GO:0006357;GO:0007409;GO:0045162;GO:0044255;GO:1903510;GO:0048858;GO:0033036;GO:0006082;GO:0051094;GO:1901136;GO:1901135;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0045944;GO:0048731;GO:1901360;GO:1901698;GO:1903508;GO:0032774;GO:0045927;GO:0048812;GO:0030030;GO:0030031;GO:0019222;GO:0031323;GO:0090304;GO:0045887;GO:0006766;GO:0031328;GO:0009100;GO:0007275;GO:0010628;GO:0051963;GO:0040007;GO:0021700;GO:0040008;GO:2000112;GO:0010557;GO:0006024;GO:0071704;GO:0010467;GO:0051960;GO:0060359;GO:2000026;GO:0010468;GO:0006351;GO:0048666;GO:0048667;GO:0009582;GO:0009583;GO:0009584;GO:0030182;GO:0019219;GO:0034613;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007267;GO:0042221;GO:0022008;GO:0009056;GO:0051179;GO:1902578;GO:0040011;GO:0044238;GO:0048699;GO:0005975;GO:0032990;GO:0007399;GO:0048856;GO:0044237;GO:0044087;GO:0044085;GO:0006790;GO:0043113;GO:0048522;GO:0044089; organonitrogen compound biosynthetic process;fat-soluble vitamin metabolic process;regulation of primary metabolic process;developmental growth;retinoid metabolic process;regulation of synaptic growth at neuromuscular junction;cell maturation;positive regulation of nitrogen compound metabolic process;membrane organization;synaptic growth at neuromuscular junction;small molecule metabolic process;cellular response to acetylcholine;regulation of macromolecule biosynthetic process;cellular component morphogenesis;organic cyclic compound biosynthetic process;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;single-organism metabolic process;neuron projection guidance;taxis;cellular macromolecule localization;cellular developmental process;protein localization;single-organism biosynthetic process;aromatic compound biosynthetic process;positive regulation of molecular function;positive regulation of biological process;diterpenoid metabolic process;postsynaptic signal transduction;chemotaxis;regulation of macromolecule metabolic process;cell development;extracellular structure organization;phototransduction, visible light;phototransduction;neuromuscular junction development;protein localization to membrane;regulation of RNA biosynthetic process;oxoacid metabolic process;regulation of cellular component organization;response to abiotic stimulus;response to organic substance;single organism signaling;organonitrogen compound metabolic process;response to external stimulus;single-multicellular organism process;protein metabolic process;localization within membrane;regulation of transcription, DNA-templated;regulation of cell projection assembly;positive regulation of hydrolase activity;extracellular matrix organization;filopodium assembly;signal transduction;positive regulation of GTPase activity;chondroitin sulfate metabolic process;glycosaminoglycan metabolic process;cellular macromolecule biosynthetic process;detection of external stimulus;aminoglycan biosynthetic process;movement of cell or subcellular component;carbohydrate derivative biosynthetic process;nitrogen compound metabolic process;neuron projection development;positive regulation of nucleobase-containing compound metabolic process;macromolecule catabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;organic substance catabolic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;neuron maturation;heterocycle metabolic process;cellular component organization;biological regulation;single-organism process;positive regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter;regulation of molecular function;regulation of biological quality;G-protein coupled receptor signaling pathway;heterocycle biosynthetic process;positive regulation of cellular component organization;positive regulation of catalytic activity;axon development;lipid metabolic process;nucleobase-containing compound metabolic process;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;signal transduction involved in cellular response to ammonium ion;response to acetylcholine;biological_process;metabolic process;acetylcholine receptor signaling pathway;nucleobase-containing compound biosynthetic process;positive regulation of macromolecule metabolic process;regulation of hydrolase activity;detection of stimulus;neuronal ion channel clustering;response to stimulus;cellular response to nitrogen compound;chondroitin sulfate proteoglycan metabolic process;positive regulation of nervous system development;proteoglycan metabolic process;response to light stimulus;positive regulation of synapse assembly;G-protein coupled acetylcholine receptor signaling pathway;aminoglycan metabolic process;single-organism membrane organization;aminoglycan catabolic process;glycosaminoglycan catabolic process;synaptic signaling;organonitrogen compound catabolic process;positive regulation of developmental growth;regulation of developmental growth;synapse organization;regulation of multicellular organismal process;regulation of synapse structure or activity;response to radiation;cell differentiation;regulation of synapse organization;RNA metabolic process;cellular response to ammonium ion;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular component assembly;signaling;positive regulation of filopodium assembly;cellular response to chemical stimulus;cell communication;axon guidance;anatomical structure morphogenesis;regulation of GTPase activity;single-organism cellular localization;synapse assembly;positive regulation of metabolic process;regulation of neuromuscular junction development;positive regulation of neuromuscular junction development;positive regulation of multicellular organismal process;positive regulation of biosynthetic process;regulation of cellular biosynthetic process;cellular localization;cellular nitrogen compound biosynthetic process;positive regulation of cellular metabolic process;developmental process;response to oxygen-containing compound;multicellular organismal process;cellular response to oxygen-containing compound;terpenoid metabolic process;isoprenoid metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of filopodium assembly;regulation of transcription from RNA polymerase II promoter;axonogenesis;clustering of voltage-gated sodium channels;cellular lipid metabolic process;mucopolysaccharide metabolic process;cell projection morphogenesis;macromolecule localization;organic acid metabolic process;positive regulation of developmental process;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;system development;organic cyclic compound metabolic process;response to nitrogen compound;positive regulation of nucleic acid-templated transcription;RNA biosynthetic process;positive regulation of growth;neuron projection morphogenesis;cell projection organization;cell projection assembly;regulation of metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of synaptic growth at neuromuscular junction;vitamin metabolic process;positive regulation of cellular biosynthetic process;glycoprotein metabolic process;multicellular organism development;positive regulation of gene expression;regulation of synapse assembly;growth;developmental maturation;regulation of growth;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;glycosaminoglycan biosynthetic process;organic substance metabolic process;gene expression;regulation of nervous system development;response to ammonium ion;regulation of multicellular organismal development;regulation of gene expression;transcription, DNA-templated;neuron development;cell morphogenesis involved in neuron differentiation;detection of abiotic stimulus;detection of light stimulus;detection of visible light;neuron differentiation;regulation of nucleobase-containing compound metabolic process;cellular protein localization;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell-cell signaling;response to chemical;neurogenesis;catabolic process;localization;single-organism localization;locomotion;primary metabolic process;generation of neurons;carbohydrate metabolic process;cell part morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;regulation of cellular component biogenesis;cellular component biogenesis;sulfur compound metabolic process;receptor clustering;positive regulation of cellular process;positive regulation of cellular component biogenesis; 5;6;4;3;8;5;5;4;4;4;4;6;5;4;5;5;2;5;3;5;3;4;4;4;4;5;4;2;7;5;4;4;4;4;6;5;5;5;6;5;4;3;4;3;4;3;3;4;4;6;4;6;5;6;4;7;5;6;5;4;5;4;5;3;5;5;5;2;7;4;4;5;5;4;6;4;3;2;2;6;7;3;3;5;5;4;5;6;4;4;3;4;4;3;3;5;5;1;2;6;5;4;5;3;5;2;5;5;4;6;5;4;6;5;4;6;7;5;5;4;4;4;3;4;4;5;5;5;6;4;4;4;2;4;4;4;6;3;6;4;5;3;6;5;3;4;5;3;5;4;2;4;2;5;6;5;2;4;7;5;7;7;6;4;7;5;3;4;3;5;4;5;5;4;6;7;4;4;4;7;6;3;6;4;5;3;4;5;5;5;5;5;4;5;4;2;4;3;6;5;6;3;5;5;5;4;5;6;5;6;4;5;6;6;5;5;3;3;5;3;4;4;3;6;3;2;3;2;3;7;4;5;5;3;3;3;3;4;5;3;3; GO:0031974;GO:0031224;GO:0031982;GO:0005773;GO:0016021;GO:0016020;GO:0005775;GO:0005576;GO:0005794;GO:0043230;GO:0043231;GO:0043233;GO:0030054;GO:0044424;GO:0044425;GO:0044420;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044431;GO:0044437;GO:0043202;GO:0012505;GO:0044444;GO:0000323;GO:0031012;GO:0043226;GO:0005605;GO:0005796;GO:0044464;GO:0005623;GO:0071944;GO:0045202;GO:0070013;GO:0044446;GO:0005886;GO:1903561;GO:0070062;GO:0005604;GO:0005737;GO:0005575;GO:0005764;GO:0005578; membrane-enclosed lumen;intrinsic component of membrane;vesicle;vacuole;integral component of membrane;membrane;vacuolar lumen;extracellular region;Golgi apparatus;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cell junction;intracellular part;membrane part;extracellular matrix component;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;Golgi apparatus part;vacuolar part;lysosomal lumen;endomembrane system;cytoplasmic part;lytic vacuole;extracellular matrix;organelle;basal lamina;Golgi lumen;cell part;cell;cell periphery;synapse;intracellular organelle lumen;intracellular organelle part;plasma membrane;extracellular vesicle;extracellular exosome;basement membrane;cytoplasm;cellular_component;lysosome;proteinaceous extracellular matrix; 2;3;4;5;4;2;5;2;4;3;4;3;2;3;2;2;2;2;3;3;3;4;4;6;3;4;6;2;2;3;5;2;2;3;2;4;3;3;3;4;3;4;1;7;3; GO:0043394;GO:0050840;GO:0035374;GO:0046872;GO:0043236;GO:0097367;GO:0033691;GO:0003674;GO:0005488;GO:0043168;GO:0036094;GO:0031406;GO:0043395;GO:0005539;GO:0001948;GO:0043169;GO:0043167;GO:0005509;GO:0043177;GO:0005515;GO:0002162;GO:0005200;GO:1901681;GO:0005198; proteoglycan binding;extracellular matrix binding;chondroitin sulfate binding;metal ion binding;laminin binding;carbohydrate derivative binding;sialic acid binding;molecular_function;binding;anion binding;small molecule binding;carboxylic acid binding;heparan sulfate proteoglycan binding;glycosaminoglycan binding;glycoprotein binding;cation binding;ion binding;calcium ion binding;organic acid binding;protein binding;dystroglycan binding;structural constituent of cytoskeleton;sulfur compound binding;structural molecule activity; 5;3;4;5;4;3;4;1;2;4;3;5;4;4;4;4;3;6;4;3;5;3;3;2; K06254 map04512; ECM-receptor interaction; IPR003645;IPR003884;IPR000082;IPR013320;IPR008993;IPR001881;IPR000742;IPR004850;IPR002350;IPR013032;IPR001791;IPR002049; Follistatin-like, N-terminal;Factor I / membrane attack complex;SEA domain;Concanavalin A-like lectin/glucanase domain;Tissue inhibitor of metalloproteinases-like, OB-fold;EGF-like calcium-binding domain;EGF-like domain;NtA (N-terminal agrin) domain;Kazal domain;EGF-like, conserved site;Laminin G domain;Laminin EGF domain; extracellular Hs22044321 3804.0 O [O] Posttranslational modification, protein turnover, chaperones; A2RU37 Uncharacterized protein C9orf170 OS=Homo sapiens OX=9606 GN=C9orf170 PE=2 SV=1 - [CI170_HUMAN] 1.212 0.741 1.187 1.392 0.713 0.849 1.63562753 nan 1.952314166 nan 1.601889339 nan 1.190743338 nan mitochondria A8MWY0 UPF0577 protein KIAA1324-like OS=Homo sapiens OX=9606 GN=KIAA1324L PE=1 SV=2 - [K132L_HUMAN] 1.135 0.972 1.181 0.988 0.909 0.844 1.167695473 nan 1.086908691 nan 1.215020576 nan 0.928492849 nan GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; IPR009030;IPR009011;IPR011641; Growth factor receptor cysteine-rich domain;Mannose-6-phosphate receptor binding domain;Tyrosine-protein kinase ephrin type A/B receptor-like; plasma membrane Hs20542492 1623.0 T [T] Signal transduction mechanisms; Q96M20 Cyclic nucleotide-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CNBD2 PE=2 SV=2 - [CNBD2_HUMAN] 1.021 0.987 0.952 1.002 1.013 1.767 1.034447822 0.714140897 0.989141165 0.583222773 0.964539007 0.664707135 1.744323791 0.048638722 GO:0044699;GO:0019953;GO:0022414;GO:0000003;GO:0007276;GO:0032501;GO:0048609;GO:0032504;GO:0044703;GO:0007283;GO:0008150;GO:0048232;GO:0051704;GO:0044702; single-organism process;sexual reproduction;reproductive process;reproduction;gamete generation;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;multi-organism reproductive process;spermatogenesis;biological_process;male gamete generation;multi-organism process;single organism reproductive process; 2;3;2;2;4;2;3;3;3;6;1;5;2;3; GO:0005737;GO:0044424;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444; cytoplasm;intracellular part;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part; 4;3;5;2;2;3;1;4; GO:0003674;GO:0005488;GO:0043167;GO:1901363;GO:1901265;GO:0043168;GO:0000166;GO:0017076;GO:0036094;GO:0030552;GO:0030551;GO:0030554;GO:0097367;GO:0097159;GO:0032559;GO:0032555;GO:0032553; molecular_function;binding;ion binding;heterocyclic compound binding;nucleoside phosphate binding;anion binding;nucleotide binding;purine nucleotide binding;small molecule binding;cAMP binding;cyclic nucleotide binding;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding; 1;2;3;3;4;4;4;5;3;5;5;6;3;3;6;5;4; IPR018490;IPR018488;IPR000595;IPR014710; Cyclic nucleotide-binding-like;Cyclic nucleotide-binding, conserved site;Cyclic nucleotide-binding domain;RmlC-like jelly roll fold; mitochondria Hs18201890 1175.0 T [T] Signal transduction mechanisms; Q9BYD3 39S ribosomal protein L4, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1 - [RM04_HUMAN] 1.264 0.886 1.064 1.046 0.862 1.139 1.426636569 nan 1.213457077 nan 1.200902935 nan 1.321345708 nan GO:0007005;GO:0044710;GO:0044711;GO:0043043;GO:1901564;GO:0019538;GO:0006807;GO:0043170;GO:1901576;GO:0044260;GO:0016043;GO:0071840;GO:0032543;GO:0008150;GO:0008152;GO:0044271;GO:0022411;GO:0006518;GO:0044249;GO:0034641;GO:0034645;GO:0043241;GO:1901566;GO:0044699;GO:0009987;GO:0043604;GO:0043603;GO:0043933;GO:0032984;GO:0071822;GO:0071704;GO:0010467;GO:0070126;GO:0070124;GO:0070125;GO:0044267;GO:0009058;GO:0009059;GO:0044763;GO:0043624;GO:0006996;GO:0044238;GO:0044237;GO:1902589;GO:0006415;GO:0006414;GO:0006413;GO:0006412; mitochondrion organization;single-organism metabolic process;single-organism biosynthetic process;peptide biosynthetic process;organonitrogen compound metabolic process;protein metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;cellular component organization or biogenesis;mitochondrial translation;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;cellular component disassembly;peptide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;protein complex disassembly;organonitrogen compound biosynthetic process;single-organism process;cellular process;amide biosynthetic process;cellular amide metabolic process;macromolecular complex subunit organization;macromolecular complex disassembly;protein complex subunit organization;organic substance metabolic process;gene expression;mitochondrial translational termination;mitochondrial translational initiation;mitochondrial translational elongation;cellular protein metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cellular protein complex disassembly;organelle organization;primary metabolic process;cellular metabolic process;single-organism organelle organization;translational termination;translational elongation;translational initiation;translation; 5;3;4;6;4;4;3;4;4;4;3;2;5;1;2;5;4;5;4;4;5;6;5;2;2;6;5;4;5;5;3;5;6;5;6;5;3;5;3;7;4;3;3;4;7;6;4;6; GO:0031975;GO:0016020;GO:0031967;GO:0031966;GO:0043231;GO:0043232;GO:0044429;GO:0044424;GO:0044464;GO:0044422;GO:0019866;GO:0043229;GO:0043227;GO:0043226;GO:0005840;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005739;GO:1990904;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0043228;GO:0030529;GO:0032991;GO:0005575; envelope;membrane;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;mitochondrial part;intracellular part;cell part;organelle part;organelle inner membrane;intracellular organelle;membrane-bounded organelle;organelle;ribosome;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;mitochondrion;ribonucleoprotein complex;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;non-membrane-bounded organelle;intracellular ribonucleoprotein complex;macromolecular complex;cellular_component; 3;2;4;4;4;4;4;3;2;2;4;3;3;2;5;3;4;4;3;5;3;2;3;5;5;3;4;2;1; GO:0005198;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0044822;GO:0003723;GO:0003735; structural molecule activity;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;poly(A) RNA binding;RNA binding;structural constituent of ribosome; 2;3;1;2;4;3;6;5;3; K02926 map03010; Ribosome; IPR013005;IPR023574;IPR002136; 50S ribosomal protein uL4;Ribosomal protein L4 domain;Ribosomal protein L4/L1e; mitochondria Hs7705722 557.0 J [J] Translation, ribosomal structure and biogenesis; O75140 GATOR complex protein DEPDC5 OS=Homo sapiens OX=9606 GN=DEPDC5 PE=1 SV=2 - [DEPD5_HUMAN] 1.012 1.524 0.593 1.176 1.111 0.698 0.664041995 nan 1.058505851 nan 0.389107612 nan 0.628262826 nan GO:0048585;GO:0048583;GO:0007165;GO:0034198;GO:0051716;GO:0009968;GO:0009966;GO:0044093;GO:0065007;GO:0065009;GO:0044700;GO:0031668;GO:0031669;GO:0009605;GO:0031667;GO:0033554;GO:0035556;GO:0050789;GO:0043547;GO:0051345;GO:0043085;GO:0050790;GO:0050794;GO:0006950;GO:0008150;GO:0009267;GO:1902532;GO:1902531;GO:0051336;GO:0050896;GO:0032007;GO:0032006;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0043087;GO:0044699;GO:0071496;GO:0009987;GO:0031929;GO:0048519;GO:0009991;GO:0042594;GO:0044763;GO:0007154;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;cellular response to amino acid starvation;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;positive regulation of molecular function;biological regulation;regulation of molecular function;single organism signaling;cellular response to extracellular stimulus;cellular response to nutrient levels;response to external stimulus;response to nutrient levels;cellular response to stress;intracellular signal transduction;regulation of biological process;positive regulation of GTPase activity;positive regulation of hydrolase activity;positive regulation of catalytic activity;regulation of catalytic activity;regulation of cellular process;response to stress;biological_process;cellular response to starvation;negative regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of hydrolase activity;response to stimulus;negative regulation of TOR signaling;regulation of TOR signaling;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;regulation of GTPase activity;single-organism process;cellular response to external stimulus;cellular process;TOR signaling;negative regulation of biological process;response to extracellular stimulus;response to starvation;single-organism cellular process;cell communication;negative regulation of cellular process; 3;3;4;6;3;4;4;4;2;3;3;4;5;3;5;4;5;2;7;6;5;4;3;3;1;5;5;5;5;2;6;6;3;2;4;3;4;6;2;4;2;6;2;4;4;3;4;3; GO:0016020;GO:0005774;GO:0098588;GO:1990130;GO:0043234;GO:0043231;GO:0005829;GO:0044424;GO:0098852;GO:0043229;GO:0043227;GO:0044437;GO:0048471;GO:0035859;GO:0044446;GO:0005773;GO:0044444;GO:0044422;GO:0000323;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0098805;GO:0043226;GO:0032991;GO:0005764;GO:0005765; membrane;vacuolar membrane;bounding membrane of organelle;Iml1 complex;protein complex;intracellular membrane-bounded organelle;cytosol;intracellular part;lytic vacuole membrane;intracellular organelle;membrane-bounded organelle;vacuolar part;perinuclear region of cytoplasm;Seh1-associated complex;intracellular organelle part;vacuole;cytoplasmic part;organelle part;lytic vacuole;cytoplasm;organelle membrane;cell part;cell;intracellular;cellular_component;whole membrane;organelle;macromolecular complex;lysosome;lysosomal membrane; 2;4;4;4;3;4;5;3;5;3;3;4;5;4;3;5;4;2;6;4;3;2;2;3;1;3;2;2;7;6; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0005488;GO:0032403;GO:0060589;GO:0005515;GO:0044877;GO:0008047;GO:0030234; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;binding;protein complex binding;nucleoside-triphosphatase regulator activity;protein binding;macromolecular complex binding;enzyme activator activity;enzyme regulator activity; 2;5;5;1;2;4;4;3;3;4;3; K20404 IPR000591;IPR027244;IPR011991; DEP domain;Vacuolar membrane-associated protein Iml1;Winged helix-turn-helix DNA-binding domain; nucleus Hs7662222 3283.0 T [T] Signal transduction mechanisms; Q13315 Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4 - [ATM_HUMAN] 0.961 0.931 1.078 0.998 0.969 1.833 1.032223416 nan 1.029927761 nan 1.157894737 nan 1.891640867 nan GO:0071044;GO:0033151;GO:0034605;GO:0044257;GO:0051656;GO:0038202;GO:0072425;GO:0051716;GO:0006303;GO:0000003;GO:0072422;GO:0001666;GO:0045132;GO:0007088;GO:0006281;GO:0048583;GO:0007281;GO:0046488;GO:0032845;GO:0051248;GO:0046486;GO:0001756;GO:0046483;GO:0042325;GO:0042327;GO:0006278;GO:0019538;GO:0010638;GO:0010639;GO:0006275;GO:0051783;GO:0051782;GO:0060322;GO:0051784;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0009891;GO:0031056;GO:0010965;GO:0046651;GO:0035556;GO:0072331;GO:0050789;GO:0002682;GO:0071840;GO:1903308;GO:0018130;GO:0006629;GO:2000278;GO:0072395;GO:0007050;GO:0043412;GO:0009266;GO:0007059;GO:0032434;GO:0002521;GO:0006302;GO:0016070;GO:0016071;GO:0010557;GO:0010556;GO:0009967;GO:0032006;GO:2001252;GO:2001251;GO:0030889;GO:0030888;GO:0051129;GO:0051128;GO:0042176;GO:0042177;GO:1901991;GO:1901990;GO:0044819;GO:0044818;GO:0007126;GO:0007127;GO:0009653;GO:0000280;GO:0045740;GO:2000573;GO:0008285;GO:0008283;GO:0006974;GO:0006975;GO:0006977;GO:0051985;GO:0044255;GO:0051983;GO:0009952;GO:0071500;GO:0046474;GO:0018105;GO:0090220;GO:0097190;GO:0097193;GO:0042592;GO:0022402;GO:0051306;GO:0008219;GO:0051304;GO:0051303;GO:0007275;GO:0032212;GO:0032210;GO:0051302;GO:0043065;GO:0043067;GO:0007276;GO:0097695;GO:0097694;GO:0043068;GO:0048599;GO:0006468;GO:0000278;GO:0007389;GO:0019219;GO:0006464;GO:0044767;GO:0044763;GO:0010389;GO:0051276;GO:0048856;GO:0006796;GO:0050000;GO:0006793;GO:0023057;GO:0048523;GO:0048522;GO:0000086;GO:2000112;GO:0000082;GO:0043523;GO:0043525;GO:0007004;GO:0033129;GO:0070661;GO:0044710;GO:0044711;GO:0045786;GO:0045787;GO:0070663;GO:1901799;GO:1901798;GO:0006661;GO:0033036;GO:0070664;GO:0051054;GO:0051053;GO:0051052;GO:2001020;GO:0072413;GO:0051704;GO:0023056;GO:0018209;GO:2000134;GO:0002327;GO:0044783;GO:0016444;GO:0016568;GO:0016569;GO:0045841;GO:0051409;GO:0045321;GO:0006807;GO:0033127;GO:0044267;GO:0044265;GO:0044260;GO:0070997;GO:0044699;GO:1904356;GO:0000723;GO:0009889;GO:0009888;GO:0050794;GO:0071478;GO:0007569;GO:1901216;GO:0051236;GO:1901214;GO:0051234;GO:0090407;GO:0051174;GO:0070192;GO:0008654;GO:0050896;GO:0010498;GO:0002695;GO:0002694;GO:0006511;GO:1903310;GO:0033044;GO:0033045;GO:0033046;GO:0033047;GO:0036092;GO:0071480;GO:0033043;GO:0009314;GO:0051649;GO:0033048;GO:0019953;GO:0007049;GO:0071479;GO:0051249;GO:0010212;GO:0010562;GO:0051246;GO:0051247;GO:0009057;GO:1902578;GO:0031399;GO:0048609;GO:0045141;GO:0007131;GO:0045143;GO:1900034;GO:0072431;GO:0002331;GO:0071897;GO:2000816;GO:0050869;GO:0043933;GO:0050864;GO:0050866;GO:0034622;GO:0006325;GO:0030071;GO:0071158;GO:0071156;GO:0045930;GO:0045935;GO:0045934;GO:0045937;GO:0031577;GO:0061136;GO:1902100;GO:0022414;GO:0022412;GO:0008340;GO:0008610;GO:0006996;GO:0044238;GO:0032205;GO:0032204;GO:0032206;GO:0032200;GO:0044237;GO:0006259;GO:0019220;GO:0019222;GO:0060249;GO:0048585;GO:0048584;GO:0048468;GO:0032846;GO:0032844;GO:0072359;GO:0072358;GO:0009408;GO:0031058;GO:1901362;GO:1901360;GO:1901361;GO:0009968;GO:0009966;GO:0048869;GO:0048513;GO:0048518;GO:0048519;GO:0002683;GO:0042127;GO:0003006;GO:0003002;GO:1902099;GO:0035282;GO:0008630;GO:0044700;GO:0044703;GO:0044702;GO:0044707;GO:0002376;GO:0048646;GO:0033554;GO:0019637;GO:0007165;GO:0022607;GO:0042157;GO:0042159;GO:0042981;GO:0072401;GO:0090068;GO:0031572;GO:0031570;GO:0031571;GO:0016570;GO:0016572;GO:0002200;GO:0071214;GO:1904884;GO:1904882;GO:0046700;GO:0012501;GO:0006950;GO:0010259;GO:0048731;GO:0034654;GO:0034655;GO:1902531;GO:0051603;GO:0044271;GO:0044270;GO:0080134;GO:0031401;GO:0001775;GO:1903051;GO:1903432;GO:0030154;GO:1902532;GO:1902533;GO:0046777;GO:0043632;GO:0006139;GO:0051321;GO:0043161;GO:0009994;GO:0034397;GO:0050865;GO:0032270;GO:0016233;GO:0006508;GO:0043009;GO:0002520;GO:0032502;GO:0006644;GO:0032501;GO:0032504;GO:0031330;GO:1903050;GO:0009987;GO:0006725;GO:1901796;GO:0007420;GO:0044770;GO:0000819;GO:0051250;GO:0098813;GO:0050670;GO:0044772;GO:0050672;GO:0000956;GO:0036293;GO:1902275;GO:0007507;GO:0044839;GO:0042113;GO:0045017;GO:0010564;GO:0010332;GO:0002329;GO:0071704;GO:0010506;GO:1902750;GO:1904358;GO:0030330;GO:1904354;GO:0006914;GO:0006915;GO:1904353;GO:0032007;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0051173;GO:0044843;GO:0009056;GO:0051179;GO:0051640;GO:0051641;GO:0006310;GO:0072434;GO:0000070;GO:0000077;GO:0000075;GO:0051726;GO:1902589;GO:0080135;GO:0007094;GO:0007095;GO:1902580;GO:0007091;GO:0007093;GO:0080090;GO:0007292;GO:1902402;GO:1902403;GO:1902400;GO:2001022;GO:0010605;GO:0010604;GO:0070727;GO:0018193;GO:0006260;GO:0030183;GO:0045839;GO:0060255;GO:0010972;GO:0046649;GO:0030162;GO:0030163;GO:0048534;GO:0019439;GO:0019438;GO:0032943;GO:0032944;GO:0032945;GO:0007067;GO:1901576;GO:1901575;GO:1903362;GO:1903363;GO:0016043;GO:0065003;GO:0065007;GO:0065008;GO:0048477;GO:0051130;GO:0071174;GO:0071173;GO:1901987;GO:0036211;GO:0008150;GO:0008152;GO:0032435;GO:1901988;GO:0044784;GO:0007399;GO:0016310;GO:0008334;GO:1904262;GO:0044248;GO:0044249;GO:0034641;GO:0009792;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0007417;GO:0036289;GO:0000726;GO:0000725;GO:0000724;GO:0022618;GO:0007346;GO:0022613;GO:0070482;GO:0009628;GO:0060429;GO:0031929;GO:0010833;GO:1904868;GO:0061053;GO:0032269;GO:0032268;GO:0007568;GO:2000045;GO:0043170;GO:0030098;GO:0030097;GO:0045861;GO:0009790;GO:0006650;GO:0031329;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:1903047;GO:1903046;GO:0090304;GO:0010948;GO:0044773;GO:0044774;GO:0051301;GO:0010942;GO:0010941;GO:1902806;GO:0071826;GO:1902807;GO:0010467;GO:0006401;GO:0006402;GO:0006403;GO:0010468;GO:0019941;GO:0042100;GO:0051402;GO:0007154;GO:0043517;GO:0043516;GO:0042770;GO:0002562;GO:0045003;GO:0090399;GO:0044087;GO:0044085;GO:1902749;GO:0048285;GO:0035825;GO:0001932;GO:0001934;GO:0044089; histone mRNA catabolic process;V(D)J recombination;cellular response to heat;cellular protein catabolic process;establishment of organelle localization;TORC1 signaling;signal transduction involved in G2 DNA damage checkpoint;cellular response to stimulus;double-strand break repair via nonhomologous end joining;reproduction;signal transduction involved in DNA damage checkpoint;response to hypoxia;meiotic chromosome segregation;regulation of mitotic nuclear division;DNA repair;regulation of response to stimulus;germ cell development;phosphatidylinositol metabolic process;negative regulation of homeostatic process;negative regulation of protein metabolic process;glycerolipid metabolic process;somitogenesis;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;RNA-dependent DNA biosynthetic process;protein metabolic process;positive regulation of organelle organization;negative regulation of organelle organization;regulation of DNA replication;regulation of nuclear division;negative regulation of cell division;head development;negative regulation of nuclear division;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;regulation of histone modification;regulation of mitotic sister chromatid separation;lymphocyte proliferation;intracellular signal transduction;signal transduction by p53 class mediator;regulation of biological process;regulation of immune system process;cellular component organization or biogenesis;regulation of chromatin modification;heterocycle biosynthetic process;lipid metabolic process;regulation of DNA biosynthetic process;signal transduction involved in cell cycle checkpoint;cell cycle arrest;macromolecule modification;response to temperature stimulus;chromosome segregation;regulation of proteasomal ubiquitin-dependent protein catabolic process;leukocyte differentiation;double-strand break repair;RNA metabolic process;mRNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;positive regulation of signal transduction;regulation of TOR signaling;positive regulation of chromosome organization;negative regulation of chromosome organization;negative regulation of B cell proliferation;regulation of B cell proliferation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein catabolic process;negative regulation of protein catabolic process;negative regulation of mitotic cell cycle phase transition;regulation of mitotic cell cycle phase transition;mitotic G1/S transition checkpoint;mitotic G2/M transition checkpoint;meiotic nuclear division;meiosis I;anatomical structure morphogenesis;nuclear division;positive regulation of DNA replication;positive regulation of DNA biosynthetic process;negative regulation of cell proliferation;cell proliferation;cellular response to DNA damage stimulus;DNA damage induced protein phosphorylation;DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;negative regulation of chromosome segregation;cellular lipid metabolic process;regulation of chromosome segregation;anterior/posterior pattern specification;cellular response to nitrosative stress;glycerophospholipid biosynthetic process;peptidyl-serine phosphorylation;chromosome localization to nuclear envelope involved in homologous chromosome segregation;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;homeostatic process;cell cycle process;mitotic sister chromatid separation;cell death;chromosome separation;establishment of chromosome localization;multicellular organism development;positive regulation of telomere maintenance via telomerase;regulation of telomere maintenance via telomerase;regulation of cell division;positive regulation of apoptotic process;regulation of programmed cell death;gamete generation;establishment of macromolecular complex localization to telomere;establishment of RNA localization to telomere;positive regulation of programmed cell death;oocyte development;protein phosphorylation;mitotic cell cycle;pattern specification process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;regulation of G2/M transition of mitotic cell cycle;chromosome organization;anatomical structure development;phosphate-containing compound metabolic process;chromosome localization;phosphorus metabolic process;negative regulation of signaling;negative regulation of cellular process;positive regulation of cellular process;G2/M transition of mitotic cell cycle;regulation of cellular macromolecule biosynthetic process;G1/S transition of mitotic cell cycle;regulation of neuron apoptotic process;positive regulation of neuron apoptotic process;telomere maintenance via telomerase;positive regulation of histone phosphorylation;leukocyte proliferation;single-organism metabolic process;single-organism biosynthetic process;negative regulation of cell cycle;positive regulation of cell cycle;regulation of leukocyte proliferation;negative regulation of proteasomal protein catabolic process;positive regulation of signal transduction by p53 class mediator;phosphatidylinositol biosynthetic process;macromolecule localization;negative regulation of leukocyte proliferation;positive regulation of DNA metabolic process;negative regulation of DNA metabolic process;regulation of DNA metabolic process;regulation of response to DNA damage stimulus;signal transduction involved in mitotic cell cycle checkpoint;multi-organism process;positive regulation of signaling;peptidyl-serine modification;negative regulation of G1/S transition of mitotic cell cycle;immature B cell differentiation;G1 DNA damage checkpoint;somatic cell DNA recombination;chromatin modification;covalent chromatin modification;negative regulation of mitotic metaphase/anaphase transition;response to nitrosative stress;leukocyte activation;nitrogen compound metabolic process;regulation of histone phosphorylation;cellular protein metabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;neuron death;single-organism process;regulation of telomere maintenance via telomere lengthening;telomere maintenance;regulation of biosynthetic process;tissue development;regulation of cellular process;cellular response to radiation;cell aging;positive regulation of neuron death;establishment of RNA localization;regulation of neuron death;establishment of localization;organophosphate biosynthetic process;regulation of phosphorus metabolic process;chromosome organization involved in meiotic cell cycle;phospholipid biosynthetic process;response to stimulus;proteasomal protein catabolic process;negative regulation of leukocyte activation;regulation of leukocyte activation;ubiquitin-dependent protein catabolic process;positive regulation of chromatin modification;regulation of chromosome organization;regulation of sister chromatid segregation;negative regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;phosphatidylinositol-3-phosphate biosynthetic process;cellular response to gamma radiation;regulation of organelle organization;response to radiation;establishment of localization in cell;negative regulation of mitotic sister chromatid segregation;sexual reproduction;cell cycle;cellular response to ionizing radiation;regulation of lymphocyte activation;response to ionizing radiation;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;macromolecule catabolic process;single-organism localization;regulation of protein modification process;multicellular organismal reproductive process;meiotic telomere clustering;reciprocal meiotic recombination;homologous chromosome segregation;regulation of cellular response to heat;signal transduction involved in mitotic G1 DNA damage checkpoint;pre-B cell allelic exclusion;DNA biosynthetic process;negative regulation of mitotic sister chromatid separation;negative regulation of B cell activation;macromolecular complex subunit organization;regulation of B cell activation;negative regulation of cell activation;cellular macromolecular complex assembly;chromatin organization;regulation of mitotic metaphase/anaphase transition;positive regulation of cell cycle arrest;regulation of cell cycle arrest;negative regulation of mitotic cell cycle;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;spindle checkpoint;regulation of proteasomal protein catabolic process;negative regulation of metaphase/anaphase transition of cell cycle;reproductive process;cellular process involved in reproduction in multicellular organism;determination of adult lifespan;lipid biosynthetic process;organelle organization;primary metabolic process;negative regulation of telomere maintenance;regulation of telomere maintenance;positive regulation of telomere maintenance;telomere organization;cellular metabolic process;DNA metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;anatomical structure homeostasis;negative regulation of response to stimulus;positive regulation of response to stimulus;cell development;positive regulation of homeostatic process;regulation of homeostatic process;circulatory system development;cardiovascular system development;response to heat;positive regulation of histone modification;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;animal organ development;positive regulation of biological process;negative regulation of biological process;negative regulation of immune system process;regulation of cell proliferation;developmental process involved in reproduction;regionalization;regulation of metaphase/anaphase transition of cell cycle;segmentation;intrinsic apoptotic signaling pathway in response to DNA damage;single organism signaling;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;immune system process;anatomical structure formation involved in morphogenesis;cellular response to stress;organophosphate metabolic process;signal transduction;cellular component assembly;lipoprotein metabolic process;lipoprotein catabolic process;regulation of apoptotic process;signal transduction involved in DNA integrity checkpoint;positive regulation of cell cycle process;G2 DNA damage checkpoint;DNA integrity checkpoint;mitotic G1 DNA damage checkpoint;histone modification;histone phosphorylation;somatic diversification of immune receptors;cellular response to abiotic stimulus;positive regulation of telomerase catalytic core complex assembly;regulation of telomerase catalytic core complex assembly;heterocycle catabolic process;programmed cell death;response to stress;multicellular organism aging;system development;nucleobase-containing compound biosynthetic process;nucleobase-containing compound catabolic process;regulation of intracellular signal transduction;proteolysis involved in cellular protein catabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;regulation of response to stress;positive regulation of protein modification process;cell activation;negative regulation of proteolysis involved in cellular protein catabolic process;regulation of TORC1 signaling;cell differentiation;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;protein autophosphorylation;modification-dependent macromolecule catabolic process;nucleobase-containing compound metabolic process;meiotic cell cycle;proteasome-mediated ubiquitin-dependent protein catabolic process;oocyte differentiation;telomere localization;regulation of cell activation;positive regulation of cellular protein metabolic process;telomere capping;proteolysis;chordate embryonic development;immune system development;developmental process;phospholipid metabolic process;multicellular organismal process;multicellular organism reproduction;negative regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;cellular aromatic compound metabolic process;regulation of signal transduction by p53 class mediator;brain development;cell cycle phase transition;sister chromatid segregation;negative regulation of lymphocyte activation;nuclear chromosome segregation;regulation of lymphocyte proliferation;mitotic cell cycle phase transition;negative regulation of lymphocyte proliferation;nuclear-transcribed mRNA catabolic process;response to decreased oxygen levels;regulation of chromatin organization;heart development;cell cycle G2/M phase transition;B cell activation;glycerolipid biosynthetic process;regulation of cell cycle process;response to gamma radiation;pre-B cell differentiation;organic substance metabolic process;regulation of autophagy;negative regulation of cell cycle G2/M phase transition;positive regulation of telomere maintenance via telomere lengthening;DNA damage response, signal transduction by p53 class mediator;negative regulation of telomere capping;autophagy;apoptotic process;regulation of telomere capping;negative regulation of TOR signaling;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell cycle G1/S phase transition;catabolic process;localization;organelle localization;cellular localization;DNA recombination;signal transduction involved in mitotic G2 DNA damage checkpoint;mitotic sister chromatid segregation;DNA damage checkpoint;cell cycle checkpoint;regulation of cell cycle;single-organism organelle organization;regulation of cellular response to stress;mitotic spindle assembly checkpoint;mitotic G2 DNA damage checkpoint;single-organism cellular localization;metaphase/anaphase transition of mitotic cell cycle;mitotic cell cycle checkpoint;regulation of primary metabolic process;female gamete generation;signal transduction involved in mitotic DNA damage checkpoint;signal transduction involved in mitotic DNA integrity checkpoint;intracellular signal transduction involved in G1 DNA damage checkpoint;positive regulation of response to DNA damage stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;peptidyl-amino acid modification;DNA replication;B cell differentiation;negative regulation of mitotic nuclear division;regulation of macromolecule metabolic process;negative regulation of G2/M transition of mitotic cell cycle;lymphocyte activation;regulation of proteolysis;protein catabolic process;hematopoietic or lymphoid organ development;aromatic compound catabolic process;aromatic compound biosynthetic process;mononuclear cell proliferation;regulation of mononuclear cell proliferation;negative regulation of mononuclear cell proliferation;mitotic nuclear division;organic substance biosynthetic process;organic substance catabolic process;regulation of cellular protein catabolic process;negative regulation of cellular protein catabolic process;cellular component organization;macromolecular complex assembly;biological regulation;regulation of biological quality;oogenesis;positive regulation of cellular component organization;mitotic spindle checkpoint;spindle assembly checkpoint;regulation of cell cycle phase transition;protein modification process;biological_process;metabolic process;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;negative regulation of cell cycle phase transition;metaphase/anaphase transition of cell cycle;nervous system development;phosphorylation;histone mRNA metabolic process;negative regulation of TORC1 signaling;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;central nervous system development;peptidyl-serine autophosphorylation;non-recombinational repair;recombinational repair;double-strand break repair via homologous recombination;ribonucleoprotein complex assembly;regulation of mitotic cell cycle;ribonucleoprotein complex biogenesis;response to oxygen levels;response to abiotic stimulus;epithelium development;TOR signaling;telomere maintenance via telomere lengthening;telomerase catalytic core complex assembly;somite development;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;aging;regulation of G1/S transition of mitotic cell cycle;macromolecule metabolic process;lymphocyte differentiation;hemopoiesis;negative regulation of proteolysis;embryo development;glycerophospholipid metabolic process;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;meiotic cell cycle process;nucleic acid metabolic process;negative regulation of cell cycle process;mitotic DNA damage checkpoint;mitotic DNA integrity checkpoint;cell division;positive regulation of cell death;regulation of cell death;regulation of cell cycle G1/S phase transition;ribonucleoprotein complex subunit organization;negative regulation of cell cycle G1/S phase transition;gene expression;RNA catabolic process;mRNA catabolic process;RNA localization;regulation of gene expression;modification-dependent protein catabolic process;B cell proliferation;neuron apoptotic process;cell communication;positive regulation of DNA damage response, signal transduction by p53 class mediator;regulation of DNA damage response, signal transduction by p53 class mediator;signal transduction in response to DNA damage;somatic diversification of immune receptors via germline recombination within a single locus;double-strand break repair via synthesis-dependent strand annealing;replicative senescence;regulation of cellular component biogenesis;cellular component biogenesis;regulation of cell cycle G2/M phase transition;organelle fission;reciprocal DNA recombination;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular component biogenesis; 8;5;5;6;4;7;8;3;6;2;7;4;5;6;4;3;4;7;3;5;5;4;4;7;7;7;4;5;5;6;5;4;4;5;4;4;3;3;4;5;7;5;5;6;2;3;2;7;5;4;6;5;5;5;4;4;8;6;5;5;6;5;5;4;6;6;6;7;7;4;4;5;5;6;6;7;7;4;5;3;6;6;6;4;3;5;4;7;4;4;4;6;5;6;8;3;5;6;4;4;6;4;5;5;4;6;6;4;6;5;4;4;5;5;5;7;5;4;5;6;3;3;7;5;3;5;5;4;3;3;3;6;6;7;6;6;5;6;4;3;4;4;4;5;7;6;7;3;5;5;5;5;5;6;2;3;8;7;7;7;7;6;7;7;4;3;3;6;5;5;4;5;2;5;4;4;4;3;5;5;5;4;5;3;5;5;4;5;2;6;4;4;8;7;6;5;5;6;8;7;5;4;4;6;3;4;6;5;5;5;5;5;5;3;6;3;4;4;6;5;8;6;6;7;6;4;6;4;6;5;7;6;6;5;5;5;6;6;7;7;2;4;4;5;4;3;4;4;4;6;3;5;6;3;5;3;3;4;3;3;5;5;4;5;5;4;5;4;4;4;4;2;2;3;4;3;5;6;6;6;3;3;3;3;2;3;4;4;4;4;5;6;6;6;5;7;6;7;4;5;3;4;4;4;5;5;3;5;4;5;5;5;6;5;5;4;6;4;7;7;5;5;5;8;6;4;3;7;4;6;4;5;5;5;7;3;2;5;2;3;5;7;2;4;6;4;5;5;5;5;6;6;6;8;5;6;4;6;5;5;5;6;8;3;4;7;5;7;5;3;6;5;6;3;5;4;4;4;6;3;2;4;3;6;7;6;6;5;4;4;4;6;6;4;6;6;4;5;7;7;8;4;4;4;4;7;6;6;6;4;7;4;6;5;4;5;5;5;6;6;5;4;4;6;6;3;5;2;3;5;4;6;7;6;5;1;2;8;6;6;5;6;7;7;4;4;4;6;2;4;5;3;4;4;5;9;5;5;6;5;5;4;4;3;5;6;5;6;6;5;5;4;7;4;5;5;6;5;6;5;5;5;4;4;4;5;4;5;5;6;6;4;4;4;7;5;7;5;6;7;4;5;7;6;6;4;5;6;6;4;7;6;3;3;7;5;7;7;7;3; GO:0044428;GO:0044424;GO:0044422;GO:0005654;GO:0044464;GO:0005622;GO:0070013;GO:0016023;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044430;GO:0005819;GO:0043227;GO:0031974;GO:0043229;GO:0043228;GO:0043226;GO:0005856;GO:0031982;GO:0044446;GO:0044444;GO:0005634;GO:0031981;GO:0031988;GO:0005737;GO:0097708;GO:0031410;GO:0005623;GO:0015630;GO:0032991;GO:1990391;GO:0005575; nuclear part;intracellular part;organelle part;nucleoplasm;cell part;intracellular;intracellular organelle lumen;cytoplasmic, membrane-bounded vesicle;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytoskeletal part;spindle;membrane-bounded organelle;membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;organelle;cytoskeleton;vesicle;intracellular organelle part;cytoplasmic part;nucleus;nuclear lumen;membrane-bounded vesicle;cytoplasm;intracellular vesicle;cytoplasmic vesicle;cell;microtubule cytoskeleton;macromolecular complex;DNA repair complex;cellular_component; 4;3;2;5;2;3;4;5;3;4;4;3;4;5;3;2;3;3;2;5;4;3;4;5;5;5;4;4;5;2;6;2;4;1; GO:0000166;GO:0005488;GO:0035004;GO:1901265;GO:0017076;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0047485;GO:0001883;GO:0001882;GO:0016740;GO:0046983;GO:0032403;GO:0005515;GO:0003674;GO:0004674;GO:0004677;GO:0004672;GO:1901363;GO:0044877;GO:0003676;GO:0003677;GO:0005524;GO:0016303;GO:0016301;GO:0003824;GO:0097159;GO:0043168;GO:0043167;GO:0030554;GO:0036094;GO:0097367;GO:0032549;GO:0052742;GO:0035639; nucleotide binding;binding;phosphatidylinositol 3-kinase activity;nucleoside phosphate binding;purine nucleotide binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;protein N-terminus binding;purine nucleoside binding;nucleoside binding;transferase activity;protein dimerization activity;protein complex binding;protein binding;molecular_function;protein serine/threonine kinase activity;DNA-dependent protein kinase activity;protein kinase activity;heterocyclic compound binding;macromolecular complex binding;nucleic acid binding;DNA binding;ATP binding;1-phosphatidylinositol-3-kinase activity;kinase activity;catalytic activity;organic cyclic compound binding;anion binding;ion binding;adenyl nucleotide binding;small molecule binding;carbohydrate derivative binding;ribonucleoside binding;phosphatidylinositol kinase activity;purine ribonucleoside triphosphate binding; 4;2;6;4;5;5;4;6;5;6;4;4;5;4;3;4;4;3;1;7;8;6;3;3;4;5;6;7;5;2;3;4;3;6;3;3;5;6;5; K04728 map04064;map04068;map04110;map04115;map04210;map04214;map05166;map05202;map05206; NF-kappa B signaling pathway;FoxO signaling pathway;Cell cycle;p53 signaling pathway;Apoptosis;Apoptosis - fly;HTLV-I infection;Transcriptional misregulation in cancer;MicroRNAs in cancer; IPR003152;IPR011009;IPR018936;IPR016024;IPR000403;IPR003151;IPR021668;IPR011989;IPR014009; FATC domain;Protein kinase-like domain;Phosphatidylinositol 3/4-kinase, conserved site;Armadillo-type fold;Phosphatidylinositol 3-/4-kinase, catalytic domain;PIK-related kinase, FAT;Telomere-length maintenance and DNA damage repair;Armadillo-like helical;PIK-related kinase; plasma membrane Hs20336203 6339.0 TBLD [T] Signal transduction mechanisms;[B] Chromatin structure and dynamics;[L] Replication, recombination and repair;[D] Cell cycle control, cell division, chromosome partitioning; P01721 Immunoglobulin lambda variable 6-57 OS=Homo sapiens OX=9606 GN=IGLV6-57 PE=1 SV=2 - [LV657_HUMAN] 1.131 1.066 0.904 1.137 0.959 1.088 1.06097561 0.200853198 1.18561001 0.157336692 0.848030019 0.45374735 1.13451512 0.341478412 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q8TD57 Dynein heavy chain 3, axonemal OS=Homo sapiens OX=9606 GN=DNAH3 PE=2 SV=1 - [DYH3_HUMAN] 0.808 1.049 1.457 0.995 0.879 0.744 0.770257388 nan 1.131968146 nan 1.388941849 nan 0.846416382 nan GO:0001539;GO:0006928;GO:0051179;GO:0044699;GO:0009987;GO:0008150;GO:0040011;GO:0007017;GO:0048870;GO:0007018;GO:0051674;GO:0044763; cilium or flagellum-dependent cell motility;movement of cell or subcellular component;localization;single-organism process;cellular process;biological_process;locomotion;microtubule-based process;cell motility;microtubule-based movement;localization of cell;single-organism cellular process; 4;4;2;2;2;1;2;4;3;5;3;3; GO:0099512;GO:0099513;GO:0044464;GO:0043229;GO:0043228;GO:0005929;GO:0030286;GO:0005874;GO:0043226;GO:0005737;GO:0044446;GO:0005858;GO:0005875;GO:0044430;GO:0005856;GO:0015630;GO:1902494;GO:0042995;GO:0005930;GO:0043234;GO:0032991;GO:0043232;GO:0044463;GO:0005623;GO:0005622;GO:0005575;GO:0044447;GO:0097014;GO:0044441;GO:0044424;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;cell part;intracellular organelle;non-membrane-bounded organelle;cilium;dynein complex;microtubule;organelle;cytoplasm;intracellular organelle part;axonemal dynein complex;microtubule associated complex;cytoskeletal part;cytoskeleton;microtubule cytoskeleton;catalytic complex;cell projection;axoneme;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cell projection part;cell;intracellular;cellular_component;axoneme part;ciliary plasm;ciliary part;intracellular part;organelle part; 2;3;2;3;3;3;5;4;2;4;3;5;4;4;5;6;4;3;4;3;2;4;3;2;3;1;4;4;3;3;2; GO:0032550;GO:0016787;GO:0035639;GO:1901363;GO:0032553;GO:0003674;GO:0005488;GO:0001883;GO:0043167;GO:0001882;GO:0016462;GO:0005524;GO:0032555;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0000166;GO:0017111;GO:0036094;GO:0003824;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0016817;GO:0032559;GO:0043168; purine ribonucleoside binding;hydrolase activity;purine ribonucleoside triphosphate binding;heterocyclic compound binding;ribonucleotide binding;molecular_function;binding;purine nucleoside binding;ion binding;nucleoside binding;pyrophosphatase activity;ATP binding;purine ribonucleotide binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;nucleotide binding;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;adenyl ribonucleotide binding;anion binding; 6;3;5;3;4;1;2;5;3;4;6;6;5;4;5;5;8;9;4;7;3;2;5;6;3;3;4;6;4; K10408 map05016; Huntington's disease; IPR004273;IPR035699;IPR013602;IPR003593;IPR024743;IPR035706;IPR026983;IPR027417;IPR024317; Dynein heavy chain domain;Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;Dynein heavy chain, domain-2;AAA+ ATPase domain;Dynein heavy chain, coiled coil stalk;Dynein heavy chain, ATP-binding dynein motor region D5;Dynein heavy chain;P-loop containing nucleoside triphosphate hydrolase;Dynein heavy chain, AAA module D4; plasma membrane Hs22067157 7626.0 Z [Z] Cytoskeleton; Q9NU22 Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2 - [MDN1_HUMAN] 0.545 0.759 1.703 0.761 0.711 0.593 0.718050066 0.759127373 1.070323488 0.927913539 2.243741765 0.399329903 0.834036568 0.713912505 GO:0042273;GO:0022607;GO:0070271;GO:0043933;GO:0034622;GO:0071840;GO:0071822;GO:0042255;GO:0042254;GO:0016043;GO:0065003;GO:0022618;GO:0022613;GO:0000027;GO:0006461;GO:0009987;GO:0008150;GO:0070925;GO:0006996;GO:0044085;GO:0071826; ribosomal large subunit biogenesis;cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;cellular macromolecular complex assembly;cellular component organization or biogenesis;protein complex subunit organization;ribosome assembly;ribosome biogenesis;cellular component organization;macromolecular complex assembly;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;ribosomal large subunit assembly;protein complex assembly;cellular process;biological_process;organelle assembly;organelle organization;cellular component biogenesis;ribonucleoprotein complex subunit organization; 5;4;4;4;6;2;5;6;5;3;5;5;4;6;5;2;1;5;4;3;5; GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0045111;GO:0005730;GO:0005634;GO:0016020;GO:0005856;GO:0043231;GO:0043232;GO:0043233;GO:0031981;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;intermediate filament cytoskeleton;nucleolus;nucleus;membrane;cytoskeleton;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;3;3;2;4;3;6;5;5;2;5;4;4;3;5;2;2;3;1;4;4;3;2; GO:1901363;GO:0032553;GO:0003674;GO:0005488;GO:0016887;GO:0032550;GO:0001883;GO:0001882;GO:0043167;GO:0035639;GO:1901265;GO:0032549;GO:0032559;GO:0005524;GO:0000166;GO:0017111;GO:0036094;GO:0003824;GO:0051082;GO:0017076;GO:0032555;GO:0016818;GO:0097367;GO:0097159;GO:0016787;GO:0016817;GO:0030554;GO:0005515;GO:0016462;GO:0043168; heterocyclic compound binding;ribonucleotide binding;molecular_function;binding;ATPase activity;purine ribonucleoside binding;purine nucleoside binding;nucleoside binding;ion binding;purine ribonucleoside triphosphate binding;nucleoside phosphate binding;ribonucleoside binding;adenyl ribonucleotide binding;ATP binding;nucleotide binding;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;unfolded protein binding;purine nucleotide binding;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;adenyl nucleotide binding;protein binding;pyrophosphatase activity;anion binding; 3;4;1;2;8;6;5;4;3;5;4;5;6;6;4;7;3;2;4;5;5;5;3;3;3;4;6;3;6;4; K14572 map03008; Ribosome biogenesis in eukaryotes; IPR003593;IPR011704;IPR002035;IPR027417;IPR012099; AAA+ ATPase domain;ATPase, dynein-related, AAA domain;von Willebrand factor, type A;P-loop containing nucleoside triphosphate hydrolase;Midasin; plasma membrane Hs20552711 4065.0 R [R] General function prediction only; Q12980 GATOR complex protein NPRL3 OS=Homo sapiens OX=9606 GN=NPRL3 PE=1 SV=1 - [NPRL3_HUMAN] 1.018 1.279 0.813 0.974 1.276 0.563 0.795934324 nan 0.763322884 nan 0.635652854 nan 0.441222571 nan GO:0048585;GO:0048583;GO:0072359;GO:0072358;GO:0007165;GO:0034198;GO:0051716;GO:0009968;GO:0009966;GO:0048513;GO:0048514;GO:0044093;GO:0048519;GO:0044700;GO:0031668;GO:0031669;GO:0044707;GO:0009605;GO:0031667;GO:0033554;GO:0003281;GO:0035556;GO:0050789;GO:0003205;GO:0009653;GO:0043547;GO:0051345;GO:0001568;GO:0065007;GO:0044699;GO:0065009;GO:0050790;GO:0009888;GO:0050794;GO:0006950;GO:0008150;GO:0009267;GO:1902532;GO:0003231;GO:1902531;GO:0051336;GO:0050896;GO:0035904;GO:0032007;GO:0032006;GO:0035909;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0043087;GO:0043085;GO:0001944;GO:0032502;GO:0032501;GO:0009987;GO:0031929;GO:0048738;GO:0048731;GO:0009991;GO:0060021;GO:0014706;GO:0071496;GO:0042594;GO:0007275;GO:0048844;GO:0044767;GO:0044763;GO:0007154;GO:0007507;GO:0003279;GO:0048856;GO:0060537;GO:0060840;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;signal transduction;cellular response to amino acid starvation;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;animal organ development;blood vessel morphogenesis;positive regulation of molecular function;negative regulation of biological process;single organism signaling;cellular response to extracellular stimulus;cellular response to nutrient levels;single-multicellular organism process;response to external stimulus;response to nutrient levels;cellular response to stress;ventricular septum development;intracellular signal transduction;regulation of biological process;cardiac chamber development;anatomical structure morphogenesis;positive regulation of GTPase activity;positive regulation of hydrolase activity;blood vessel development;biological regulation;single-organism process;regulation of molecular function;regulation of catalytic activity;tissue development;regulation of cellular process;response to stress;biological_process;cellular response to starvation;negative regulation of intracellular signal transduction;cardiac ventricle development;regulation of intracellular signal transduction;regulation of hydrolase activity;response to stimulus;aorta development;negative regulation of TOR signaling;regulation of TOR signaling;aorta morphogenesis;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;regulation of GTPase activity;positive regulation of catalytic activity;vasculature development;developmental process;multicellular organismal process;cellular process;TOR signaling;cardiac muscle tissue development;system development;response to extracellular stimulus;palate development;striated muscle tissue development;cellular response to external stimulus;response to starvation;multicellular organism development;artery morphogenesis;single-organism developmental process;single-organism cellular process;cell communication;heart development;cardiac septum development;anatomical structure development;muscle tissue development;artery development;negative regulation of cellular process; 3;3;5;5;4;6;3;4;4;4;4;4;2;3;4;5;3;3;5;4;5;5;2;4;3;7;6;4;2;2;3;4;4;3;3;1;5;5;5;5;5;2;6;6;6;6;3;2;4;3;4;6;5;5;2;2;2;6;5;4;4;4;6;4;4;4;5;3;3;4;4;4;3;5;5;3; GO:1990130;GO:0043234;GO:0035859;GO:0032991;GO:0005575; Iml1 complex;protein complex;Seh1-associated complex;macromolecular complex;cellular_component; 4;3;4;2;1; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;5;5;1;4;4;3; K20406 IPR005365; Nitrogen permease regulator 3; mitochondria Hs6912302 1168.0 S [S] Function unknown; Q6DHV5 Protein CC2D2B OS=Homo sapiens OX=9606 GN=CC2D2B PE=2 SV=3 - [C2D2B_HUMAN] 1.014 1.18 0.846 0.974 1.316 0.635 0.859322034 nan 0.740121581 nan 0.716949153 nan 0.482522796 nan cytosol Hs22044427 340.0 R [R] General function prediction only; Q8IWZ5 Tripartite motif-containing protein 42 OS=Homo sapiens OX=9606 GN=TRIM42 PE=1 SV=2 - [TRI42_HUMAN] 1.034 1.619 0.581 0.944 1.328 0.246 0.638665843 nan 0.710843373 nan 0.358863496 nan 0.185240964 nan GO:0005622;GO:0044464;GO:0005623;GO:0005575; intracellular;cell part;cell;cellular_component; 3;2;2;1; GO:0043169;GO:0046914;GO:0043167;GO:0003674;GO:0005488;GO:0046872;GO:0008270; cation binding;transition metal ion binding;ion binding;molecular_function;binding;metal ion binding;zinc ion binding; 4;6;3;1;2;5;7; K12018 IPR013783;IPR003961;IPR013083;IPR000315;IPR017903;IPR001841;IPR017907; Immunoglobulin-like fold;Fibronectin type III;Zinc finger, RING/FYVE/PHD-type;B-box-type zinc finger;COS domain;Zinc finger, RING-type;Zinc finger, RING-type, conserved site; nucleus Q14686 Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3 - [NCOA6_HUMAN] 1.158 1.037 1.103 0.91 1.045 0.582 1.116682739 0.101556706 0.870813397 0.289362805 1.06364513 0.482614294 0.556937799 0.047918268 GO:0035774;GO:0090087;GO:1903508;GO:0008104;GO:0080090;GO:0051046;GO:0032024;GO:0051049;GO:2001141;GO:0048584;GO:0048583;GO:0032846;GO:0008585;GO:0032844;GO:0007507;GO:0072359;GO:0044710;GO:0044281;GO:1901362;GO:0044255;GO:1901360;GO:0032774;GO:0009755;GO:0051716;GO:0000003;GO:0048869;GO:0035773;GO:0045137;GO:0046879;GO:0048511;GO:0048513;GO:0006260;GO:0071331;GO:0071333;GO:0048518;GO:0033036;GO:0019725;GO:0030154;GO:0006367;GO:0051050;GO:0060255;GO:0006366;GO:0045184;GO:0003006;GO:0090276;GO:0090277;GO:0030518;GO:0045944;GO:0010033;GO:0046483;GO:0044700;GO:0044702;GO:0044707;GO:0034284;GO:0071322;GO:0071326;GO:0048878;GO:0002376;GO:0042698;GO:0007154;GO:0060322;GO:0006259;GO:0033554;GO:0071407;GO:0019438;GO:0007165;GO:0031958;GO:0043401;GO:0022602;GO:0009891;GO:0023051;GO:0051254;GO:0032940;GO:0006807;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0030073;GO:1901576;GO:1904951;GO:0050708;GO:0044260;GO:0008406;GO:0065007;GO:0014070;GO:0010468;GO:0065008;GO:0018130;GO:0070201;GO:0046545;GO:0006629;GO:0009306;GO:0009889;GO:0006810;GO:0050796;GO:0050794;GO:0006950;GO:0008150;GO:0001678;GO:0030097;GO:0034654;GO:0034641;GO:0061178;GO:0046660;GO:0006310;GO:0010604;GO:0016070;GO:0043170;GO:0046903;GO:0044271;GO:0007420;GO:0050714;GO:0050896;GO:0009058;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0006352;GO:0008152;GO:0051173;GO:0023056;GO:0044249;GO:0015833;GO:0023052;GO:1903530;GO:0070887;GO:1903532;GO:0051047;GO:0010647;GO:0010646;GO:0044699;GO:0032880;GO:0009719;GO:0006139;GO:0042886;GO:0051234;GO:0001541;GO:0042921;GO:0002520;GO:0031325;GO:0032502;GO:1901700;GO:0032501;GO:0048608;GO:0048609;GO:0032504;GO:0044238;GO:0034645;GO:0009987;GO:0071396;GO:0007548;GO:1903506;GO:0006974;GO:0032870;GO:0046883;GO:0045893;GO:0046887;GO:0055082;GO:0032879;GO:0009893;GO:0090304;GO:0009725;GO:0051252;GO:1902680;GO:0010628;GO:0072358;GO:0030099;GO:0048731;GO:0048545;GO:0071495;GO:0048856;GO:0060341;GO:0031328;GO:0061458;GO:0031326;GO:0071383;GO:0031323;GO:0042592;GO:0042593;GO:0010467;GO:0009749;GO:0007275;GO:0007417;GO:0030522;GO:0030520;GO:0033993;GO:0006281;GO:2000112;GO:0033500;GO:0071705;GO:0071704;GO:0071310;GO:0006357;GO:0097659;GO:0071702;GO:0048534;GO:0045935;GO:0019219;GO:0006725;GO:0023061;GO:0010817;GO:0044767;GO:0022414;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0051649;GO:0007267;GO:0042221;GO:0019222;GO:0051179;GO:1902578;GO:0051641;GO:0009746;GO:1901701;GO:0009743;GO:0007399;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:0009914;GO:0015031;GO:0048522; positive regulation of insulin secretion involved in cellular response to glucose stimulus;regulation of peptide transport;positive regulation of nucleic acid-templated transcription;protein localization;regulation of primary metabolic process;regulation of secretion;positive regulation of insulin secretion;regulation of transport;regulation of RNA biosynthetic process;positive regulation of response to stimulus;regulation of response to stimulus;positive regulation of homeostatic process;female gonad development;regulation of homeostatic process;heart development;circulatory system development;single-organism metabolic process;small molecule metabolic process;organic cyclic compound biosynthetic process;cellular lipid metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;hormone-mediated signaling pathway;cellular response to stimulus;reproduction;cellular developmental process;insulin secretion involved in cellular response to glucose stimulus;development of primary sexual characteristics;hormone secretion;rhythmic process;animal organ development;DNA replication;cellular response to hexose stimulus;cellular response to glucose stimulus;positive regulation of biological process;macromolecule localization;cellular homeostasis;cell differentiation;transcription initiation from RNA polymerase II promoter;positive regulation of transport;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;establishment of protein localization;developmental process involved in reproduction;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;intracellular steroid hormone receptor signaling pathway;positive regulation of transcription from RNA polymerase II promoter;response to organic substance;heterocycle metabolic process;single organism signaling;single organism reproductive process;single-multicellular organism process;response to monosaccharide;cellular response to carbohydrate stimulus;cellular response to monosaccharide stimulus;chemical homeostasis;immune system process;ovulation cycle;cell communication;head development;DNA metabolic process;cellular response to stress;cellular response to organic cyclic compound;aromatic compound biosynthetic process;signal transduction;corticosteroid receptor signaling pathway;steroid hormone mediated signaling pathway;ovulation cycle process;positive regulation of biosynthetic process;regulation of signaling;positive regulation of RNA metabolic process;secretion by cell;nitrogen compound metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;organic substance biosynthetic process;positive regulation of establishment of protein localization;regulation of protein secretion;cellular macromolecule metabolic process;gonad development;biological regulation;response to organic cyclic compound;regulation of gene expression;regulation of biological quality;heterocycle biosynthetic process;regulation of establishment of protein localization;development of primary female sexual characteristics;lipid metabolic process;protein secretion;regulation of biosynthetic process;transport;regulation of insulin secretion;regulation of cellular process;response to stress;biological_process;cellular glucose homeostasis;hemopoiesis;nucleobase-containing compound biosynthetic process;cellular nitrogen compound metabolic process;regulation of insulin secretion involved in cellular response to glucose stimulus;female sex differentiation;DNA recombination;positive regulation of macromolecule metabolic process;RNA metabolic process;macromolecule metabolic process;secretion;cellular nitrogen compound biosynthetic process;brain development;positive regulation of protein secretion;response to stimulus;biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;metabolic process;positive regulation of nitrogen compound metabolic process;positive regulation of signaling;cellular biosynthetic process;peptide transport;signaling;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;positive regulation of secretion;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of protein localization;response to endogenous stimulus;nucleobase-containing compound metabolic process;amide transport;establishment of localization;ovarian follicle development;glucocorticoid receptor signaling pathway;immune system development;positive regulation of cellular metabolic process;developmental process;response to oxygen-containing compound;multicellular organismal process;reproductive structure development;multicellular organismal reproductive process;multicellular organism reproduction;primary metabolic process;cellular macromolecule biosynthetic process;cellular process;cellular response to lipid;sex differentiation;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;cellular response to hormone stimulus;regulation of hormone secretion;positive regulation of transcription, DNA-templated;positive regulation of hormone secretion;cellular chemical homeostasis;regulation of localization;positive regulation of metabolic process;nucleic acid metabolic process;response to hormone;regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;cardiovascular system development;myeloid cell differentiation;system development;response to steroid hormone;cellular response to endogenous stimulus;anatomical structure development;regulation of cellular localization;positive regulation of cellular biosynthetic process;reproductive system development;regulation of cellular biosynthetic process;cellular response to steroid hormone stimulus;regulation of cellular metabolic process;homeostatic process;glucose homeostasis;gene expression;response to glucose;multicellular organism development;central nervous system development;intracellular receptor signaling pathway;intracellular estrogen receptor signaling pathway;response to lipid;DNA repair;regulation of cellular macromolecule biosynthetic process;carbohydrate homeostasis;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;regulation of transcription from RNA polymerase II promoter;nucleic acid-templated transcription;organic substance transport;hematopoietic or lymphoid organ development;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;signal release;regulation of hormone levels;single-organism developmental process;reproductive process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;establishment of localization in cell;cell-cell signaling;response to chemical;regulation of metabolic process;localization;single-organism localization;cellular localization;response to hexose;cellular response to oxygen-containing compound;response to carbohydrate;nervous system development;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;hormone transport;protein transport;positive regulation of cellular process; 4;5;7;4;4;5;6;4;6;3;3;3;5;3;4;5;3;4;5;4;4;6;5;3;2;4;5;4;6;2;4;6;8;7;2;3;4;5;8;3;4;7;4;3;5;5;6;7;4;4;3;3;3;6;6;7;5;2;3;4;4;5;4;6;5;4;7;6;3;4;3;5;4;3;4;5;2;7;6;4;3;6;4;4;2;5;5;3;5;5;5;4;5;4;4;6;3;3;1;6;5;5;4;4;5;6;4;5;4;5;5;4;5;2;3;6;5;5;6;7;2;4;3;4;6;2;5;4;4;4;4;4;2;4;3;4;5;3;4;8;3;4;2;4;2;4;3;3;3;5;2;6;4;7;5;5;4;6;4;5;3;3;5;4;5;6;5;5;6;4;5;4;3;4;5;5;5;6;4;4;7;5;8;4;5;5;7;5;4;6;6;5;3;5;7;7;5;4;5;5;4;5;4;3;2;4;5;3;4;4;4;3;3;2;3;3;7;5;5;5;6;6;5;3;5;5;3; GO:0031981;GO:0005667;GO:0031974;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0034708;GO:0044422;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0044451;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0035097;GO:1902494;GO:0043226;GO:0032991;GO:0005575;GO:0070013; nuclear lumen;transcription factor complex;membrane-enclosed lumen;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;methyltransferase complex;organelle part;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;nucleoplasm part;cell part;intracellular organelle;cell;intracellular;histone methyltransferase complex;catalytic complex;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 5;4;2;5;3;4;3;4;3;4;2;3;5;3;5;5;2;3;2;3;5;4;2;2;1;4; GO:0003713;GO:0003712;GO:0044877;GO:0003674;GO:0005488;GO:0000989;GO:0000988;GO:0035258;GO:0035257;GO:0030374;GO:0019899;GO:0042974;GO:0051427;GO:0005515;GO:0005102;GO:0003682;GO:0008134;GO:0030331;GO:0046966;GO:0046965; transcription coactivator activity;transcription cofactor activity;macromolecular complex binding;molecular_function;binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;steroid hormone receptor binding;nuclear hormone receptor binding;ligand-dependent nuclear receptor transcription coactivator activity;enzyme binding;retinoic acid receptor binding;hormone receptor binding;protein binding;receptor binding;chromatin binding;transcription factor binding;estrogen receptor binding;thyroid hormone receptor binding;retinoid X receptor binding; 5;4;3;1;2;3;2;7;6;6;4;5;5;3;4;4;4;8;5;6; K14971 IPR026638;IPR032715;IPR015943; Nuclear receptor coactivator 6;Nuclear receptor coactivator 6, putative nucleic acid-binding region;WD40/YVTN repeat-like-containing domain; nucleus Q16775 Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2 - [GLO2_HUMAN] 0.888 0.769 1.687 0.834 0.854 0.948 1.154746424 nan 0.976580796 nan 2.193758127 nan 1.110070258 nan GO:0044281;GO:0044282;GO:0044712;GO:0044710;GO:0043043;GO:0019184;GO:0032787;GO:0051596;GO:0043436;GO:0006575;GO:1901564;GO:1901566;GO:0042398;GO:0006807;GO:1901576;GO:1901575;GO:0008150;GO:0008152;GO:0044271;GO:0044272;GO:0043603;GO:0006750;GO:0006518;GO:0019243;GO:1901615;GO:0044248;GO:0044249;GO:0034641;GO:0044699;GO:0006749;GO:0009987;GO:0043604;GO:0006081;GO:0006082;GO:0006089;GO:0019752;GO:0006090;GO:0009438;GO:0071704;GO:0046185;GO:0061727;GO:0009058;GO:0044763;GO:0009056;GO:0044238;GO:0005975;GO:0042180;GO:0042182;GO:0044237;GO:0006790; small molecule metabolic process;small molecule catabolic process;single-organism catabolic process;single-organism metabolic process;peptide biosynthetic process;nonribosomal peptide biosynthetic process;monocarboxylic acid metabolic process;methylglyoxal catabolic process;oxoacid metabolic process;cellular modified amino acid metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;cellular modified amino acid biosynthetic process;nitrogen compound metabolic process;organic substance biosynthetic process;organic substance catabolic process;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;sulfur compound biosynthetic process;cellular amide metabolic process;glutathione biosynthetic process;peptide metabolic process;methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;organic hydroxy compound metabolic process;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;single-organism process;glutathione metabolic process;cellular process;amide biosynthetic process;cellular aldehyde metabolic process;organic acid metabolic process;lactate metabolic process;carboxylic acid metabolic process;pyruvate metabolic process;methylglyoxal metabolic process;organic substance metabolic process;aldehyde catabolic process;methylglyoxal catabolic process to lactate;biosynthetic process;single-organism cellular process;catabolic process;primary metabolic process;carbohydrate metabolic process;cellular ketone metabolic process;ketone catabolic process;cellular metabolic process;sulfur compound metabolic process; 4;5;4;3;6;7;7;6;5;4;4;5;5;3;4;4;1;2;5;5;5;6;5;7;4;4;4;4;2;5;2;6;4;4;5;6;8;5;3;5;6;3;3;3;3;4;4;5;3;4; GO:0031974;GO:0031982;GO:0043230;GO:0043231;GO:0043233;GO:0005829;GO:0044429;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044446;GO:0044444;GO:0005737;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0005759;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;mitochondrial part;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasmic part;cytoplasm;mitochondrion;cell part;cell;intracellular;extracellular exosome;mitochondrial matrix;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;3;4;3;5;4;3;2;2;3;3;2;3;4;4;5;2;2;3;4;5;3;1;4;2; GO:0046872;GO:0004416;GO:0003674;GO:0005488;GO:0016787;GO:0016788;GO:0003824;GO:0016790;GO:0043169;GO:0043167; metal ion binding;hydroxyacylglutathione hydrolase activity;molecular_function;binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;thiolester hydrolase activity;cation binding;ion binding; 5;6;1;2;3;4;2;5;4;3; K01069 map00620; Pyruvate metabolism; IPR035680;IPR001279;IPR032282;IPR017782; Hydroxyacylglutathione hydrolase, MBL domain;Metallo-beta-lactamase;Hydroxyacylglutathione hydrolase, C-terminal domain;Hydroxyacylglutathione hydrolase; mitochondria Hs4885389 542.0 R [R] General function prediction only; P40967 Melanocyte protein PMEL OS=Homo sapiens OX=9606 GN=PMEL PE=1 SV=2 - [PMEL_HUMAN] 0.84 0.975 1.543 0.779 0.972 0.71 0.861538462 0.186875064 0.801440329 0.115834811 1.582564103 0.010388388 0.730452675 0.530673724 GO:0042438;GO:0048753;GO:0032438;GO:0016050;GO:1901360;GO:0044237;GO:0071840;GO:0044710;GO:0044711;GO:0042440;GO:0071704;GO:0016043;GO:0033059;GO:0044699;GO:0044763;GO:0043473;GO:0006582;GO:1901576;GO:0046189;GO:0009987;GO:0006725;GO:0009058;GO:0008150;GO:0008152;GO:0019438;GO:0018958;GO:0046148;GO:0019748;GO:0006996;GO:0044249;GO:1901362;GO:0044550;GO:1901615;GO:1901617; melanin biosynthetic process;pigment granule organization;melanosome organization;vesicle organization;organic cyclic compound metabolic process;cellular metabolic process;cellular component organization or biogenesis;single-organism metabolic process;single-organism biosynthetic process;pigment metabolic process;organic substance metabolic process;cellular component organization;cellular pigmentation;single-organism process;single-organism cellular process;pigmentation;melanin metabolic process;organic substance biosynthetic process;phenol-containing compound biosynthetic process;cellular process;cellular aromatic compound metabolic process;biosynthetic process;biological_process;metabolic process;aromatic compound biosynthetic process;phenol-containing compound metabolic process;pigment biosynthetic process;secondary metabolic process;organelle organization;cellular biosynthetic process;organic cyclic compound biosynthetic process;secondary metabolite biosynthetic process;organic hydroxy compound metabolic process;organic hydroxy compound biosynthetic process; 5;5;6;5;4;3;2;3;4;4;3;3;4;2;3;3;4;4;6;2;4;3;1;2;5;5;5;4;4;4;5;5;4;5; GO:0005770;GO:0005783;GO:0005886;GO:0048770;GO:0005789;GO:0042175;GO:0043229;GO:0071944;GO:0005773;GO:0005774;GO:0043227;GO:0043226;GO:0031224;GO:0010008;GO:0005737;GO:0044446;GO:0031982;GO:0016023;GO:0031410;GO:0016021;GO:0016020;GO:0031988;GO:0044432;GO:0044437;GO:0032585;GO:0031902;GO:0098805;GO:0005794;GO:0098588;GO:0005771;GO:0097708;GO:0031090;GO:0042470;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044440;GO:0044424;GO:0044425;GO:0005768;GO:0044422;GO:0012505; late endosome;endoplasmic reticulum;plasma membrane;pigment granule;endoplasmic reticulum membrane;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;cell periphery;vacuole;vacuolar membrane;membrane-bounded organelle;organelle;intrinsic component of membrane;endosome membrane;cytoplasm;intracellular organelle part;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;integral component of membrane;membrane;membrane-bounded vesicle;endoplasmic reticulum part;vacuolar part;multivesicular body membrane;late endosome membrane;whole membrane;Golgi apparatus;bounding membrane of organelle;multivesicular body;intracellular vesicle;organelle membrane;melanosome;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;endosomal part;intracellular part;membrane part;endosome;organelle part;endomembrane system; 5;4;3;6;3;3;3;3;5;4;3;2;3;5;4;3;4;5;5;4;2;5;4;4;7;6;3;4;4;6;4;3;7;4;2;2;3;1;4;2;5;3;2;4;2;3; K17304 IPR013783;IPR000601;IPR022409; Immunoglobulin-like fold;PKD domain;PKD/Chitinase domain; plasma membrane Q9H5Q4 Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1 - [TFB2M_HUMAN] 1.081 1.003 0.936 0.993 1.261 0.594 1.0777667 0.673823573 0.787470262 0.352004064 0.933200399 0.750848882 0.471054718 0.06046029 GO:0080090;GO:0019222;GO:1901362;GO:0071840;GO:0044710;GO:0044711;GO:0010604;GO:0048518;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009893;GO:0009891;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:1901360;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0006352;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0007005;GO:0044699;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0006807;GO:0000959;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0010628;GO:2000112;GO:0010557;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0006996;GO:0044238;GO:0044237;GO:1902589;GO:0006390;GO:0006391;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism metabolic process;single-organism biosynthetic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;mitochondrion organization;single-organism process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;mitochondrial RNA metabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of gene expression;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;cellular metabolic process;single-organism organelle organization;transcription from mitochondrial promoter;transcription initiation from mitochondrial promoter;positive regulation of cellular process; 4;3;5;2;3;4;4;2;4;6;4;5;3;4;7;4;4;3;2;4;5;4;3;1;2;5;5;5;6;5;6;7;6;4;4;5;5;2;4;7;2;4;7;6;5;5;4;6;3;6;5;5;4;4;5;5;6;5;2;3;5;5;5;5;3;5;3;4;4;4;3;3;4;5;6;3; GO:0031974;GO:0043231;GO:0043232;GO:0043233;GO:0030054;GO:0044429;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0009295;GO:0044446;GO:0044444;GO:0042645;GO:0005737;GO:0005739;GO:0044464;GO:0005623;GO:0005759;GO:0005575;GO:0070013; membrane-enclosed lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell junction;mitochondrial part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;nucleoid;intracellular organelle part;cytoplasmic part;mitochondrial nucleoid;cytoplasm;mitochondrion;cell part;cell;mitochondrial matrix;cellular_component;intracellular organelle lumen; 2;4;4;3;2;4;3;2;3;3;3;3;2;2;3;4;3;4;5;2;2;5;1;4; GO:1901363;GO:0003712;GO:0016740;GO:0016741;GO:0008173;GO:0008170;GO:0003674;GO:0005488;GO:0003676;GO:0008168;GO:0008649;GO:0000989;GO:0000988;GO:0003824;GO:0097159;GO:0044822;GO:0003723;GO:0016433;GO:0008757;GO:0000179; heterocyclic compound binding;transcription cofactor activity;transferase activity;transferase activity, transferring one-carbon groups;RNA methyltransferase activity;N-methyltransferase activity;molecular_function;binding;nucleic acid binding;methyltransferase activity;rRNA methyltransferase activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;catalytic activity;organic cyclic compound binding;poly(A) RNA binding;RNA binding;rRNA (adenine) methyltransferase activity;S-adenosylmethionine-dependent methyltransferase activity;rRNA (adenine-N6,N6-)-dimethyltransferase activity; 3;4;3;4;6;6;1;2;4;5;7;3;2;2;3;6;5;8;6;7; K17653 IPR016861;IPR001737;IPR020598;IPR029063; Mitochondrial transcription factor TFB2;Ribosomal RNA adenine methyltransferase KsgA/Erm;Ribosomal RNA adenine methylase transferase, N-terminal;S-adenosyl-L-methionine-dependent methyltransferase; mitochondria Hs11641289 820.0 A [A] RNA processing and modification; Q96AG4 Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1 - [LRC59_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0016020;GO:0005783;GO:0031974;GO:0031975;GO:0042175;GO:0043229;GO:0043228;GO:0042645;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0005575;GO:0031090;GO:0016021;GO:0005635;GO:0005739;GO:0009295;GO:0044432;GO:0005759;GO:0098588;GO:0031967;GO:0012505;GO:0005789;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044428;GO:0044429;GO:0044424;GO:0044425;GO:0005634;GO:0044422; membrane;endoplasmic reticulum;membrane-enclosed lumen;envelope;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;non-membrane-bounded organelle;mitochondrial nucleoid;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;cellular_component;organelle membrane;integral component of membrane;nuclear envelope;mitochondrion;nucleoid;endoplasmic reticulum part;mitochondrial matrix;bounding membrane of organelle;organelle envelope;endomembrane system;endoplasmic reticulum membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;nuclear part;mitochondrial part;intracellular part;membrane part;nucleus;organelle part; 2;4;2;3;3;3;3;3;3;2;3;4;1;3;4;4;5;2;4;5;4;4;3;3;4;4;3;2;2;3;3;4;4;4;4;3;2;5;2; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0044822;GO:0003723;GO:0097159; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;poly(A) RNA binding;RNA binding;organic cyclic compound binding; 3;1;2;4;6;5;3; IPR003591;IPR001611;IPR032675; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Leucine-rich repeat domain, L domain-like; cytosol, peroxisome Hs8924090 315.0 S [S] Function unknown; O60841 Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4 - [IF2P_HUMAN] 1.055 0.991 0.773 1.474 1.165 0.542 1.064581231 nan 1.265236052 nan 0.780020182 nan 0.465236052 nan GO:0080090;GO:0019222;GO:0010608;GO:0043043;GO:0060255;GO:0006446;GO:1901564;GO:1901566;GO:0019538;GO:0006807;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0044271;GO:0010556;GO:0006518;GO:0044249;GO:0034641;GO:0034645;GO:0051246;GO:0034248;GO:0043604;GO:0032268;GO:0043603;GO:0043170;GO:0031326;GO:0031323;GO:2000112;GO:0071704;GO:0010467;GO:0010468;GO:0009987;GO:1901576;GO:0009058;GO:0009059;GO:0051171;GO:0044238;GO:0044237;GO:0006417;GO:0006413;GO:0006412; regulation of primary metabolic process;regulation of metabolic process;posttranscriptional regulation of gene expression;peptide biosynthetic process;regulation of macromolecule metabolic process;regulation of translational initiation;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;nitrogen compound metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule biosynthetic process;peptide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;regulation of protein metabolic process;regulation of cellular amide metabolic process;amide biosynthetic process;regulation of cellular protein metabolic process;cellular amide metabolic process;macromolecule metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;cellular process;organic substance biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;regulation of translation;translational initiation;translation; 4;3;6;6;4;5;4;5;4;3;2;5;4;2;4;3;1;2;5;5;5;4;4;5;5;5;6;5;5;4;5;4;6;3;5;5;2;4;3;5;4;3;3;6;4;6; GO:0005829;GO:0044424;GO:0005622;GO:0005737;GO:0044444;GO:0044464;GO:0005623;GO:0005575; cytosol;intracellular part;intracellular;cytoplasm;cytoplasmic part;cell part;cell;cellular_component; 5;3;3;4;4;2;2;1; GO:1901363;GO:0000166;GO:0046872;GO:0003924;GO:0016818;GO:0097367;GO:0016817;GO:0016787;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0003824;GO:0097159;GO:0019001;GO:0032555;GO:0032550;GO:0032553;GO:0003743;GO:0035639;GO:0043168;GO:0043169;GO:0043167;GO:0032561;GO:0044822;GO:0008135;GO:0003723;GO:0001883;GO:0001882;GO:0016462;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;metal ion binding;GTPase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;hydrolase activity;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;catalytic activity;organic cyclic compound binding;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;translation initiation factor activity;purine ribonucleoside triphosphate binding;anion binding;cation binding;ion binding;guanyl ribonucleotide binding;poly(A) RNA binding;translation factor activity, RNA binding;RNA binding;purine nucleoside binding;nucleoside binding;pyrophosphatase activity;nucleoside-triphosphatase activity;small molecule binding; 3;4;5;8;5;3;4;3;1;2;4;4;5;5;6;2;3;6;5;6;4;7;5;4;4;3;6;6;6;5;5;4;6;7;3; K03243 map03013; RNA transport; IPR023115;IPR000795;IPR015760;IPR004161;IPR009000;IPR005225;IPR027417; Translation initiation factor IF- 2, domain 3;Transcription factor, GTP-binding domain;Translation initiation factor IF- 2;Translation elongation factor EFTu-like, domain 2;Translation protein, beta-barrel domain;Small GTP-binding protein domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs15451892 2429.0 J [J] Translation, ribosomal structure and biogenesis; Q9H1J5 Protein Wnt-8a OS=Homo sapiens OX=9606 GN=WNT8A PE=1 SV=2 - [WNT8A_HUMAN] 0.748 0.946 1.58 0.623 0.968 1.532 0.790697674 nan 0.643595041 nan 1.670190275 nan 1.582644628 nan GO:0080090;GO:0019222;GO:0048584;GO:0048468;GO:0030111;GO:0072358;GO:0007165;GO:0007166;GO:0044324;GO:1901362;GO:0071840;GO:0060923;GO:0014033;GO:0051716;GO:0048863;GO:0048864;GO:0014034;GO:0009966;GO:0048869;GO:0048513;GO:0048518;GO:0048762;GO:0060255;GO:0048583;GO:0003002;GO:2001141;GO:0010033;GO:0046483;GO:0044700;GO:0044707;GO:0009790;GO:0014029;GO:0016055;GO:0072359;GO:0007154;GO:0019438;GO:0042693;GO:0042692;GO:0060828;GO:0090263;GO:0023051;GO:0030177;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0000904;GO:0000902;GO:0044260;GO:0009948;GO:0016043;GO:0065007;GO:1901360;GO:0061311;GO:0061317;GO:0061316;GO:0048646;GO:0018130;GO:0009889;GO:0009888;GO:0050794;GO:0014031;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0045165;GO:0044271;GO:0009952;GO:0060070;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0009967;GO:0003306;GO:0032774;GO:0030154;GO:0023056;GO:0044249;GO:0034641;GO:0009792;GO:0023052;GO:0034645;GO:0060485;GO:0061061;GO:0009798;GO:0010647;GO:0009653;GO:0044699;GO:0006139;GO:0043009;GO:0032502;GO:0032501;GO:0055007;GO:0009987;GO:0006725;GO:1903506;GO:0001101;GO:0051252;GO:0043170;GO:0048738;GO:0048731;GO:0007507;GO:0031326;GO:0031323;GO:0060021;GO:0090304;GO:0014706;GO:0051146;GO:0007275;GO:0007389;GO:0010646;GO:0033993;GO:2000112;GO:0032989;GO:0071704;GO:0010467;GO:0010468;GO:0032526;GO:0030182;GO:0019219;GO:0035051;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0042221;GO:0022008;GO:0044335;GO:1901700;GO:0044238;GO:0048699;GO:0007399;GO:0048856;GO:0044237;GO:0001837;GO:0060911;GO:0060537;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;cell development;regulation of Wnt signaling pathway;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;regulation of transcription involved in anterior/posterior axis specification;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cardiac muscle cell fate commitment;neural crest cell differentiation;cellular response to stimulus;stem cell differentiation;stem cell development;neural crest cell fate commitment;regulation of signal transduction;cellular developmental process;animal organ development;positive regulation of biological process;mesenchymal cell differentiation;regulation of macromolecule metabolic process;regulation of response to stimulus;regionalization;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;single organism signaling;single-multicellular organism process;embryo development;neural crest formation;Wnt signaling pathway;circulatory system development;cell communication;aromatic compound biosynthetic process;muscle cell fate commitment;muscle cell differentiation;regulation of canonical Wnt signaling pathway;positive regulation of canonical Wnt signaling pathway;regulation of signaling;positive regulation of Wnt signaling pathway;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;anterior/posterior axis specification;cellular component organization;biological regulation;organic cyclic compound metabolic process;cell surface receptor signaling pathway involved in heart development;canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment;canonical Wnt signaling pathway involved in heart development;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;regulation of biosynthetic process;tissue development;regulation of cellular process;mesenchymal cell development;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cell fate commitment;cellular nitrogen compound biosynthetic process;anterior/posterior pattern specification;canonical Wnt signaling pathway;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of signal transduction;Wnt signaling pathway involved in heart development;RNA biosynthetic process;cell differentiation;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;cellular macromolecule biosynthetic process;mesenchyme development;muscle structure development;axis specification;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;chordate embryonic development;developmental process;multicellular organismal process;cardiac muscle cell differentiation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;response to acid chemical;regulation of RNA metabolic process;macromolecule metabolic process;cardiac muscle tissue development;system development;heart development;regulation of cellular biosynthetic process;regulation of cellular metabolic process;palate development;nucleic acid metabolic process;striated muscle tissue development;striated muscle cell differentiation;multicellular organism development;pattern specification process;regulation of cell communication;response to lipid;regulation of cellular macromolecule biosynthetic process;cellular component morphogenesis;organic substance metabolic process;gene expression;regulation of gene expression;response to retinoic acid;neuron differentiation;regulation of nucleobase-containing compound metabolic process;cardiocyte differentiation;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;response to chemical;neurogenesis;canonical Wnt signaling pathway involved in neural crest cell differentiation;response to oxygen-containing compound;primary metabolic process;generation of neurons;nervous system development;anatomical structure development;cellular metabolic process;epithelial to mesenchymal transition;cardiac cell fate commitment;muscle tissue development;positive regulation of cellular process; 4;3;3;4;5;5;4;5;7;5;2;7;7;3;6;5;5;4;4;4;2;6;4;3;5;6;4;4;3;3;5;4;6;5;4;5;6;5;6;6;3;5;3;2;7;4;5;5;4;6;3;2;4;5;6;5;3;5;4;4;3;6;1;2;5;5;5;5;6;7;2;6;5;6;4;5;6;5;3;4;4;6;2;5;5;4;5;4;3;2;4;7;2;2;6;2;4;7;4;5;4;5;4;4;5;4;4;5;6;6;4;4;4;5;6;4;3;5;5;5;6;5;5;3;3;5;3;4;3;6;8;4;3;7;5;3;3;6;6;5;3; GO:0044421;GO:0031012;GO:0005615;GO:0005575;GO:0005576;GO:0005578; extracellular region part;extracellular matrix;extracellular space;cellular_component;extracellular region;proteinaceous extracellular matrix; 2;2;3;1;2;3; GO:0003674;GO:0005488;GO:0001664;GO:0048018;GO:0098772;GO:0030545;GO:0030546;GO:0005109;GO:0005515;GO:0005102;GO:0004871; molecular_function;binding;G-protein coupled receptor binding;receptor agonist activity;molecular function regulator;receptor regulator activity;receptor activator activity;frizzled binding;protein binding;receptor binding;signal transducer activity; 1;2;5;3;2;3;4;6;3;4;2; K00714 map04310;map04390;map04550;map04916;map05166;map05200;map05205;map05217; Wnt signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Melanogenesis;HTLV-I infection;Pathways in cancer;Proteoglycans in cancer;Basal cell carcinoma; IPR005817;IPR013301;IPR018161;IPR034312; Wnt;Wnt-8 protein;Wnt protein, conserved site;Protein Wnt-8A/8C; extracellular Hs17505195 727.0 T [T] Signal transduction mechanisms; P08603 Complement factor H OS=Homo sapiens OX=9606 GN=CFH PE=1 SV=4 - [CFAH_HUMAN] 1.09 0.967 1.04 0.961 0.983 0.912 1.127197518 3.58E-17 0.977619532 0.81335533 1.07549121 2.18E-16 0.927772126 0.000312274 GO:0006954;GO:0030449;GO:0080090;GO:0019222;GO:0032101;GO:0048584;GO:0048583;GO:0050727;GO:0002673;GO:0002920;GO:0030162;GO:0050789;GO:0044699;GO:0044710;GO:0072376;GO:0051246;GO:0009611;GO:0071704;GO:0010467;GO:0002682;GO:0031347;GO:0048518;GO:0065007;GO:1903034;GO:0010468;GO:0060255;GO:0045087;GO:2000257;GO:0006952;GO:0006950;GO:0050776;GO:0006956;GO:0006957;GO:0008152;GO:0006955;GO:0016485;GO:0002526;GO:0006959;GO:0006508;GO:0044238;GO:0070613;GO:0009605;GO:0051604;GO:0002684;GO:0019538;GO:0050896;GO:0050778;GO:0043170;GO:0002376;GO:0002697;GO:0002253;GO:0002252;GO:0008150;GO:1903317;GO:0080134; inflammatory response;regulation of complement activation;regulation of primary metabolic process;regulation of metabolic process;regulation of response to external stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of inflammatory response;regulation of acute inflammatory response;regulation of humoral immune response;regulation of proteolysis;regulation of biological process;single-organism process;single-organism metabolic process;protein activation cascade;regulation of protein metabolic process;response to wounding;organic substance metabolic process;gene expression;regulation of immune system process;regulation of defense response;positive regulation of biological process;biological regulation;regulation of response to wounding;regulation of gene expression;regulation of macromolecule metabolic process;innate immune response;regulation of protein activation cascade;defense response;response to stress;regulation of immune response;complement activation;complement activation, alternative pathway;metabolic process;immune response;protein processing;acute inflammatory response;humoral immune response;proteolysis;primary metabolic process;regulation of protein processing;response to external stimulus;protein maturation;positive regulation of immune system process;protein metabolic process;response to stimulus;positive regulation of immune response;macromolecule metabolic process;immune system process;regulation of immune effector process;activation of immune response;immune effector process;biological_process;regulation of protein maturation;regulation of response to stress; 5;5;4;3;4;3;3;5;6;5;6;2;2;3;3;5;4;3;5;3;5;2;2;5;5;4;4;4;4;3;4;4;5;2;3;6;6;4;5;3;7;3;5;3;4;2;4;4;2;4;3;3;1;6;4; GO:0044421;GO:0043227;GO:0005575;GO:1903561;GO:0070062;GO:0005615;GO:0072562;GO:0043226;GO:0031982;GO:0043230;GO:0005576; extracellular region part;membrane-bounded organelle;cellular_component;extracellular vesicle;extracellular exosome;extracellular space;blood microparticle;organelle;vesicle;extracellular organelle;extracellular region; 2;3;1;3;4;3;3;2;4;3;2; GO:0005539;GO:0003674;GO:0043394;GO:0008201;GO:0043168;GO:0043167;GO:1901681;GO:0001948;GO:0005515;GO:0043395;GO:0097367;GO:0005488; glycosaminoglycan binding;molecular_function;proteoglycan binding;heparin binding;anion binding;ion binding;sulfur compound binding;glycoprotein binding;protein binding;heparan sulfate proteoglycan binding;carbohydrate derivative binding;binding; 4;1;5;4;4;3;3;4;3;4;3;2; K04004 map04610;map05150; Complement and coagulation cascades;Staphylococcus aureus infection; IPR000436; Sushi/SCR/CCP domain; extracellular A0A087WSY4 Immunoglobulin heavy variable 4-30-2 OS=Homo sapiens OX=9606 GN=IGHV4-30-2 PE=3 SV=1 - [HV432_HUMAN] 1.092 1.034 0.773 1.326 0.824 1.862 1.056092843 nan 1.609223301 nan 0.747582205 nan 2.259708738 nan IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular A0A0A0MS14 Immunoglobulin heavy variable 1-45 OS=Homo sapiens OX=9606 GN=IGHV1-45 PE=3 SV=1 - [HV145_HUMAN] 1.018 1.095 0.99 0.973 1.022 1.326 0.929680365 nan 0.952054795 nan 0.904109589 nan 1.297455969 nan IPR013106;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular A0A087WSY6 Immunoglobulin kappa variable 3D-15 OS=Homo sapiens OX=9606 GN=IGKV3D-15 PE=3 SV=6 - [KVD15_HUMAN] 1.006 1.128 0.921 0.91 1.177 1.179 0.891843972 0.143569038 0.773152082 1.15E-05 0.816489362 5.02E-05 1.001699235 0.478559019 IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P02647 Apolipoprotein A-I OS=Homo sapiens OX=9606 GN=APOA1 PE=1 SV=1 - [APOA1_HUMAN] 1.012 1.174 0.816 0.993 1.209 0.725 0.862010221 2.73E-178 0.82133995 1.83E-186 0.695059625 nan 0.599669148 3.43E-11 GO:0007599;GO:0051046;GO:0051048;GO:0051049;GO:0007596;GO:0044281;GO:0002701;GO:0044283;GO:0051716;GO:0051496;GO:0051495;GO:0051493;GO:0051492;GO:0016101;GO:0046503;GO:0031103;GO:0031102;GO:0031100;GO:0048468;GO:0030299;GO:0046486;GO:0042325;GO:0010631;GO:0009605;GO:0019538;GO:0010638;GO:0009896;GO:0009894;GO:0009893;GO:0009891;GO:0010647;GO:0002700;GO:0031175;GO:0035556;GO:0051223;GO:0051224;GO:0050789;GO:0000904;GO:0051346;GO:0051345;GO:0006887;GO:0097006;GO:1901360;GO:0043149;GO:0070201;GO:0098602;GO:0006629;GO:0009308;GO:0098609;GO:0043412;GO:0042439;GO:0032956;GO:0060761;GO:0032489;GO:0032488;GO:0050713;GO:0050711;GO:0050710;GO:0071345;GO:0046470;GO:0006695;GO:0006694;GO:0009967;GO:0006576;GO:0051246;GO:0033209;GO:0046578;GO:0046579;GO:0051129;GO:0051128;GO:0009416;GO:0065005;GO:1901566;GO:0014070;GO:1900026;GO:1900024;GO:0060284;GO:0050878;GO:0008283;GO:0051017;GO:0002440;GO:0002739;GO:0046889;GO:0044255;GO:0030258;GO:0046474;GO:0034380;GO:0030038;GO:0045923;GO:0034381;GO:0031032;GO:0060341;GO:0030030;GO:0030036;GO:0042592;GO:0022407;GO:0008211;GO:0034384;GO:0007275;GO:0022408;GO:0055090;GO:0002682;GO:0033993;GO:0055092;GO:0055091;GO:0048598;GO:0006468;GO:0019217;GO:0019216;GO:0019218;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0040011;GO:0035270;GO:0048856;GO:0050994;GO:0050996;GO:0006066;GO:0006796;GO:2000026;GO:0006793;GO:0023057;GO:0048523;GO:0048522;GO:0060192;GO:0034115;GO:0034114;GO:0034113;GO:0034446;GO:0048678;GO:0031348;GO:0007162;GO:0060191;GO:0007165;GO:0007166;GO:0019915;GO:0031347;GO:0032692;GO:0044710;GO:0044711;GO:0045785;GO:0007369;GO:0050727;GO:0032691;GO:0044093;GO:0044092;GO:0033036;GO:0050704;GO:0034367;GO:0034368;GO:0034369;GO:1902653;GO:1902652;GO:0030301;GO:0010033;GO:0098742;GO:0023056;GO:0018206;GO:0034641;GO:1903531;GO:1903530;GO:0015918;GO:0015850;GO:0015914;GO:0051051;GO:0050821;GO:0031399;GO:0006807;GO:0044242;GO:0044267;GO:0009653;GO:0051180;GO:0044260;GO:0097164;GO:0043086;GO:0050919;GO:0007186;GO:0018158;GO:0050793;GO:0050790;GO:0009889;GO:0050794;GO:0051239;GO:0051235;GO:0051234;GO:0090407;GO:0051336;GO:0051174;GO:0006897;GO:0032368;GO:0008654;GO:0046394;GO:0050896;GO:0006898;GO:0050892;GO:0002697;GO:0048545;GO:0009719;GO:0002698;GO:0006633;GO:0060193;GO:0006631;GO:0051241;GO:0032102;GO:0033043;GO:0009314;GO:0006639;GO:0006638;GO:0060759;GO:0070887;GO:0044699;GO:0032880;GO:0000902;GO:0044057;GO:0044058;GO:0034370;GO:0031099;GO:0010565;GO:0010769;GO:0050702;GO:1903034;GO:1903035;GO:0016126;GO:0016125;GO:0032612;GO:0032611;GO:0090132;GO:0090130;GO:0042493;GO:0048731;GO:0010903;GO:0016337;GO:0030325;GO:0043933;GO:0035376;GO:0010901;GO:0046890;GO:0001523;GO:0072330;GO:0030182;GO:0010810;GO:0010811;GO:0043627;GO:0042221;GO:0022008;GO:0007264;GO:0008610;GO:0006996;GO:0044238;GO:0044237;GO:0006775;GO:0019220;GO:0019221;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0007266;GO:0008104;GO:0055081;GO:1901362;GO:0071840;GO:0009968;GO:0009966;GO:0048869;GO:0048513;GO:0010720;GO:0048518;GO:0048519;GO:0002683;GO:0031589;GO:0032652;GO:0032651;GO:0015711;GO:0007603;GO:0007602;GO:0045184;GO:0043534;GO:0043436;GO:0055114;GO:0003008;GO:0044700;GO:1901564;GO:0016192;GO:0044707;GO:0051094;GO:0016053;GO:0002376;GO:0002374;GO:0070508;GO:0033554;GO:0019637;GO:0098856;GO:0033700;GO:0034377;GO:0034375;GO:0022607;GO:0022600;GO:0034372;GO:0022603;GO:0006928;GO:0051674;GO:0042157;GO:0042158;GO:0043542;GO:0014012;GO:0045055;GO:0009306;GO:0032970;GO:0016477;GO:0045723;GO:0044712;GO:0061564;GO:0034097;GO:0006811;GO:0006810;GO:0050728;GO:0006952;GO:0006950;GO:0050817;GO:0006954;GO:0006955;GO:1902533;GO:0042304;GO:0048732;GO:0045597;GO:0046903;GO:0051606;GO:0080134;GO:0001775;GO:0061365;GO:1901617;GO:1901615;GO:0090208;GO:0090207;GO:0030154;GO:0035025;GO:0035023;GO:1904950;GO:1902531;GO:0032374;GO:0032371;GO:0032502;GO:0006644;GO:0032501;GO:0006641;GO:0006721;GO:0031331;GO:0009987;GO:0032879;GO:0050777;GO:0050776;GO:0001959;GO:0050673;GO:0001816;GO:0001817;GO:0010470;GO:0010770;GO:0001818;GO:0051057;GO:0051056;GO:1904478;GO:0006935;GO:0045017;GO:0002576;GO:0032989;GO:0032101;GO:0071704;GO:0071310;GO:0034433;GO:0034434;GO:0034435;GO:0071702;GO:0007586;GO:0034612;GO:0009058;GO:0009059;GO:0002718;GO:0002719;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0042180;GO:1902589;GO:0080090;GO:0010804;GO:0010803;GO:0006820;GO:0032231;GO:0032233;GO:0042330;GO:0009611;GO:0018193;GO:0045834;GO:0010896;GO:0010898;GO:0030155;GO:0006766;GO:0060255;GO:0032787;GO:0045995;GO:0010872;GO:0010873;GO:0010876;GO:0030168;GO:0070586;GO:0070587;GO:0048870;GO:0048878;GO:0019433;GO:0031667;GO:0032940;GO:0070328;GO:1901576;GO:1901575;GO:0050708;GO:0030029;GO:0071356;GO:0050706;GO:0050707;GO:0050701;GO:0016043;GO:0016042;GO:0065003;GO:0002367;GO:0065007;GO:0001960;GO:0065009;GO:0065008;GO:0051130;GO:1904729;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0042632;GO:0002740;GO:0031647;GO:0061572;GO:0006869;GO:0016310;GO:0050801;GO:0030300;GO:0043691;GO:0044248;GO:0044249;GO:0051006;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0044241;GO:0001667;GO:0010646;GO:0007265;GO:0043085;GO:0046464;GO:0022610;GO:0046461;GO:0060352;GO:0060353;GO:0060354;GO:0009628;GO:0046165;GO:0055088;GO:0044106;GO:0045595;GO:0007010;GO:0055085;GO:0008202;GO:0008203;GO:0007584;GO:0032268;GO:0006082;GO:0009725;GO:0043170;GO:0045940;GO:0009790;GO:0033344;GO:0009991;GO:0006656;GO:0006650;GO:0031329;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0019752;GO:0050663;GO:0071825;GO:0071827;GO:0071822;GO:0044085;GO:0006720;GO:0048666;GO:0009581;GO:0009582;GO:0009583;GO:0009584;GO:0007229;GO:0002252;GO:0007155;GO:0007154;GO:0051004;GO:0050709;GO:0007015;GO:0048699;GO:0007399;GO:0022604;GO:0044087;GO:0015748;GO:0015031;GO:0001932;GO:0001935;GO:0044089; hemostasis;regulation of secretion;negative regulation of secretion;regulation of transport;blood coagulation;small molecule metabolic process;negative regulation of production of molecular mediator of immune response;small molecule biosynthetic process;cellular response to stimulus;positive regulation of stress fiber assembly;positive regulation of cytoskeleton organization;regulation of cytoskeleton organization;regulation of stress fiber assembly;diterpenoid metabolic process;glycerolipid catabolic process;axon regeneration;neuron projection regeneration;organ regeneration;cell development;intestinal cholesterol absorption;glycerolipid metabolic process;regulation of phosphorylation;epithelial cell migration;response to external stimulus;protein metabolic process;positive regulation of organelle organization;positive regulation of catabolic process;regulation of catabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of cell communication;regulation of production of molecular mediator of immune response;neuron projection development;intracellular signal transduction;regulation of protein transport;negative regulation of protein transport;regulation of biological process;cell morphogenesis involved in differentiation;negative regulation of hydrolase activity;positive regulation of hydrolase activity;exocytosis;regulation of plasma lipoprotein particle levels;organic cyclic compound metabolic process;stress fiber assembly;regulation of establishment of protein localization;single organism cell adhesion;lipid metabolic process;amine metabolic process;cell-cell adhesion;macromolecule modification;ethanolamine-containing compound metabolic process;regulation of actin cytoskeleton organization;negative regulation of response to cytokine stimulus;regulation of Cdc42 protein signal transduction;Cdc42 protein signal transduction;negative regulation of interleukin-1 beta secretion;negative regulation of interleukin-1 secretion;negative regulation of cytokine secretion;cellular response to cytokine stimulus;phosphatidylcholine metabolic process;cholesterol biosynthetic process;steroid biosynthetic process;positive regulation of signal transduction;cellular biogenic amine metabolic process;regulation of protein metabolic process;tumor necrosis factor-mediated signaling pathway;regulation of Ras protein signal transduction;positive regulation of Ras protein signal transduction;negative regulation of cellular component organization;regulation of cellular component organization;response to light stimulus;protein-lipid complex assembly;organonitrogen compound biosynthetic process;response to organic cyclic compound;positive regulation of substrate adhesion-dependent cell spreading;regulation of substrate adhesion-dependent cell spreading;regulation of cell development;regulation of body fluid levels;cell proliferation;actin filament bundle assembly;production of molecular mediator of immune response;regulation of cytokine secretion involved in immune response;positive regulation of lipid biosynthetic process;cellular lipid metabolic process;lipid modification;glycerophospholipid biosynthetic process;high-density lipoprotein particle assembly;contractile actin filament bundle assembly;positive regulation of fatty acid metabolic process;plasma lipoprotein particle clearance;actomyosin structure organization;regulation of cellular localization;cell projection organization;actin cytoskeleton organization;homeostatic process;regulation of cell-cell adhesion;glucocorticoid metabolic process;high-density lipoprotein particle clearance;multicellular organism development;negative regulation of cell-cell adhesion;acylglycerol homeostasis;regulation of immune system process;response to lipid;sterol homeostasis;phospholipid homeostasis;embryonic morphogenesis;protein phosphorylation;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of steroid metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;locomotion;endocrine system development;anatomical structure development;regulation of lipid catabolic process;positive regulation of lipid catabolic process;alcohol metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of signaling;negative regulation of cellular process;positive regulation of cellular process;negative regulation of lipase activity;negative regulation of heterotypic cell-cell adhesion;regulation of heterotypic cell-cell adhesion;heterotypic cell-cell adhesion;substrate adhesion-dependent cell spreading;response to axon injury;negative regulation of defense response;negative regulation of cell adhesion;regulation of lipase activity;signal transduction;cell surface receptor signaling pathway;lipid storage;regulation of defense response;negative regulation of interleukin-1 production;single-organism metabolic process;single-organism biosynthetic process;positive regulation of cell adhesion;gastrulation;regulation of inflammatory response;negative regulation of interleukin-1 beta production;positive regulation of molecular function;negative regulation of molecular function;macromolecule localization;regulation of interleukin-1 secretion;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;secondary alcohol biosynthetic process;secondary alcohol metabolic process;cholesterol transport;response to organic substance;cell-cell adhesion via plasma-membrane adhesion molecules;positive regulation of signaling;peptidyl-methionine modification;cellular nitrogen compound metabolic process;negative regulation of secretion by cell;regulation of secretion by cell;sterol transport;organic hydroxy compound transport;phospholipid transport;negative regulation of transport;protein stabilization;regulation of protein modification process;nitrogen compound metabolic process;cellular lipid catabolic process;cellular protein metabolic process;anatomical structure morphogenesis;vitamin transport;cellular macromolecule metabolic process;ammonium ion metabolic process;negative regulation of catalytic activity;negative chemotaxis;G-protein coupled receptor signaling pathway;protein oxidation;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;maintenance of location;establishment of localization;organophosphate biosynthetic process;regulation of hydrolase activity;regulation of phosphorus metabolic process;endocytosis;regulation of lipid transport;phospholipid biosynthetic process;carboxylic acid biosynthetic process;response to stimulus;receptor-mediated endocytosis;intestinal absorption;regulation of immune effector process;response to steroid hormone;response to endogenous stimulus;negative regulation of immune effector process;fatty acid biosynthetic process;positive regulation of lipase activity;fatty acid metabolic process;negative regulation of multicellular organismal process;negative regulation of response to external stimulus;regulation of organelle organization;response to radiation;acylglycerol metabolic process;neutral lipid metabolic process;regulation of response to cytokine stimulus;cellular response to chemical stimulus;single-organism process;regulation of protein localization;cell morphogenesis;regulation of system process;regulation of digestive system process;triglyceride-rich lipoprotein particle remodeling;regeneration;regulation of cellular ketone metabolic process;regulation of cell morphogenesis involved in differentiation;interleukin-1 beta secretion;regulation of response to wounding;negative regulation of response to wounding;sterol biosynthetic process;sterol metabolic process;interleukin-1 production;interleukin-1 beta production;epithelium migration;tissue migration;response to drug;system development;negative regulation of very-low-density lipoprotein particle remodeling;single organismal cell-cell adhesion;adrenal gland development;macromolecular complex subunit organization;sterol import;regulation of very-low-density lipoprotein particle remodeling;regulation of lipid biosynthetic process;retinoid metabolic process;monocarboxylic acid biosynthetic process;neuron differentiation;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;response to estrogen;response to chemical;neurogenesis;small GTPase mediated signal transduction;lipid biosynthetic process;organelle organization;primary metabolic process;cellular metabolic process;fat-soluble vitamin metabolic process;regulation of phosphate metabolic process;cytokine-mediated signaling pathway;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;Rho protein signal transduction;protein localization;anion homeostasis;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;animal organ development;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;negative regulation of immune system process;cell-substrate adhesion;regulation of interleukin-1 production;regulation of interleukin-1 beta production;organic anion transport;phototransduction, visible light;phototransduction;establishment of protein localization;blood vessel endothelial cell migration;oxoacid metabolic process;oxidation-reduction process;system process;single organism signaling;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;positive regulation of developmental process;organic acid biosynthetic process;immune system process;cytokine secretion involved in immune response;cholesterol import;cellular response to stress;organophosphate metabolic process;intestinal lipid absorption;phospholipid efflux;plasma lipoprotein particle assembly;high-density lipoprotein particle remodeling;cellular component assembly;digestive system process;very-low-density lipoprotein particle remodeling;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;lipoprotein metabolic process;lipoprotein biosynthetic process;endothelial cell migration;peripheral nervous system axon regeneration;regulated exocytosis;protein secretion;regulation of actin filament-based process;cell migration;positive regulation of fatty acid biosynthetic process;single-organism catabolic process;axon development;response to cytokine;ion transport;transport;negative regulation of inflammatory response;defense response;response to stress;coagulation;inflammatory response;immune response;positive regulation of intracellular signal transduction;regulation of fatty acid biosynthetic process;gland development;positive regulation of cell differentiation;secretion;detection of stimulus;regulation of response to stress;cell activation;positive regulation of triglyceride lipase activity;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;positive regulation of triglyceride metabolic process;regulation of triglyceride metabolic process;cell differentiation;positive regulation of Rho protein signal transduction;regulation of Rho protein signal transduction;negative regulation of establishment of protein localization;regulation of intracellular signal transduction;regulation of cholesterol transport;regulation of sterol transport;developmental process;phospholipid metabolic process;multicellular organismal process;triglyceride metabolic process;terpenoid metabolic process;positive regulation of cellular catabolic process;cellular process;regulation of localization;negative regulation of immune response;regulation of immune response;regulation of cytokine-mediated signaling pathway;epithelial cell proliferation;cytokine production;regulation of cytokine production;regulation of gastrulation;positive regulation of cell morphogenesis involved in differentiation;negative regulation of cytokine production;positive regulation of small GTPase mediated signal transduction;regulation of small GTPase mediated signal transduction;regulation of intestinal absorption;chemotaxis;glycerolipid biosynthetic process;platelet degranulation;cellular component morphogenesis;regulation of response to external stimulus;organic substance metabolic process;cellular response to organic substance;steroid esterification;sterol esterification;cholesterol esterification;organic substance transport;digestion;response to tumor necrosis factor;biosynthetic process;macromolecule biosynthetic process;regulation of cytokine production involved in immune response;negative regulation of cytokine production involved in immune response;catabolic process;localization;single-organism localization;cellular localization;cellular ketone metabolic process;single-organism organelle organization;regulation of primary metabolic process;negative regulation of tumor necrosis factor-mediated signaling pathway;regulation of tumor necrosis factor-mediated signaling pathway;anion transport;regulation of actin filament bundle assembly;positive regulation of actin filament bundle assembly;taxis;response to wounding;peptidyl-amino acid modification;positive regulation of lipid metabolic process;regulation of triglyceride catabolic process;positive regulation of triglyceride catabolic process;regulation of cell adhesion;vitamin metabolic process;regulation of macromolecule metabolic process;monocarboxylic acid metabolic process;regulation of embryonic development;regulation of cholesterol esterification;positive regulation of cholesterol esterification;lipid localization;platelet activation;cell-cell adhesion involved in gastrulation;regulation of cell-cell adhesion involved in gastrulation;cell motility;chemical homeostasis;triglyceride catabolic process;response to nutrient levels;secretion by cell;triglyceride homeostasis;organic substance biosynthetic process;organic substance catabolic process;regulation of protein secretion;actin filament-based process;cellular response to tumor necrosis factor;regulation of interleukin-1 beta secretion;regulation of cytokine secretion;interleukin-1 secretion;cellular component organization;lipid catabolic process;macromolecular complex assembly;cytokine production involved in immune response;biological regulation;negative regulation of cytokine-mediated signaling pathway;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;regulation of intestinal lipid absorption;wound healing;protein modification process;biological_process;metabolic process;cholesterol homeostasis;negative regulation of cytokine secretion involved in immune response;regulation of protein stability;actin filament bundle organization;lipid transport;phosphorylation;ion homeostasis;regulation of intestinal cholesterol absorption;reverse cholesterol transport;cellular catabolic process;cellular biosynthetic process;positive regulation of lipoprotein lipase activity;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;lipid digestion;ameboidal-type cell migration;regulation of cell communication;Ras protein signal transduction;positive regulation of catalytic activity;acylglycerol catabolic process;biological adhesion;neutral lipid catabolic process;cell adhesion molecule production;regulation of cell adhesion molecule production;negative regulation of cell adhesion molecule production;response to abiotic stimulus;alcohol biosynthetic process;lipid homeostasis;cellular amine metabolic process;regulation of cell differentiation;cytoskeleton organization;transmembrane transport;steroid metabolic process;cholesterol metabolic process;response to nutrient;regulation of cellular protein metabolic process;organic acid metabolic process;response to hormone;macromolecule metabolic process;positive regulation of steroid metabolic process;embryo development;cholesterol efflux;response to extracellular stimulus;phosphatidylcholine biosynthetic process;glycerophospholipid metabolic process;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;cytokine secretion;protein-lipid complex subunit organization;plasma lipoprotein particle organization;protein complex subunit organization;cellular component biogenesis;isoprenoid metabolic process;neuron development;detection of external stimulus;detection of abiotic stimulus;detection of light stimulus;detection of visible light;integrin-mediated signaling pathway;immune effector process;cell adhesion;cell communication;regulation of lipoprotein lipase activity;negative regulation of protein secretion;actin filament organization;generation of neurons;nervous system development;regulation of cell morphogenesis;regulation of cellular component biogenesis;organophosphate ester transport;protein transport;regulation of protein phosphorylation;endothelial cell proliferation;positive regulation of cellular component biogenesis; 5;5;4;4;5;4;4;5;3;5;6;6;5;7;6;6;5;5;4;6;5;7;6;3;4;5;4;4;3;4;4;4;5;5;5;4;2;5;6;6;5;3;4;7;5;3;4;5;4;5;4;5;4;9;9;7;6;5;6;5;8;6;4;6;5;7;7;7;4;4;5;6;5;5;5;5;5;4;3;5;3;5;5;4;5;6;5;6;5;4;6;4;4;5;4;5;6;5;4;5;7;3;5;7;7;4;7;6;5;6;6;3;4;3;2;5;3;5;5;5;5;4;4;3;3;3;7;6;6;5;4;5;4;4;6;4;5;4;5;5;3;4;4;5;5;6;4;4;3;6;5;6;4;7;6;7;4;5;3;8;4;4;5;6;5;6;3;5;6;3;5;5;3;5;4;4;5;5;5;4;3;4;4;3;3;3;3;5;5;5;6;5;5;6;2;7;4;4;5;3;4;6;7;5;3;4;5;4;6;5;4;4;2;4;5;4;5;5;4;5;6;7;5;4;7;6;5;6;5;4;4;4;4;4;5;4;7;4;5;8;7;6;5;5;6;3;6;6;5;4;3;3;6;6;6;3;3;3;3;8;4;7;5;2;4;4;4;4;5;2;2;3;4;5;6;6;6;5;4;8;5;4;3;3;4;5;3;3;5;2;4;8;4;4;5;7;4;5;4;4;6;4;4;3;5;6;7;7;6;5;4;4;6;4;6;5;5;4;5;4;3;4;5;3;5;6;4;4;5;3;4;4;8;5;4;5;5;5;8;8;3;5;7;6;2;5;2;7;6;5;2;3;4;4;5;4;4;4;5;5;4;6;6;5;4;5;7;4;4;3;5;6;7;8;5;4;6;3;5;5;5;3;2;3;3;4;4;4;6;6;6;4;4;3;4;7;4;6;6;4;5;4;7;5;5;5;4;5;5;6;3;5;8;5;4;8;4;4;6;4;7;7;5;6;3;5;5;4;2;5;3;3;4;6;5;5;1;2;8;5;4;7;5;6;6;7;8;4;4;8;2;4;5;3;5;5;4;7;5;7;2;6;4;4;4;3;6;6;5;4;5;4;5;7;4;5;4;4;4;5;5;8;4;6;6;5;5;5;4;4;6;5;5;4;5;3;5;5;4;4;5;6;6;3;3;4;7;5;6;7;5;5;3;5;5;7;5;3; GO:0034358;GO:0005783;GO:0005788;GO:0034774;GO:0044424;GO:0044421;GO:0044422;GO:0005773;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0070013;GO:0005769;GO:0071682;GO:0016023;GO:0034361;GO:0034364;GO:0034365;GO:0034366;GO:0043230;GO:0043231;GO:0043233;GO:0005829;GO:0072562;GO:0044433;GO:0044432;GO:0030141;GO:0034385;GO:1990777;GO:0060205;GO:0005768;GO:0031974;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0042627;GO:0012505;GO:0044446;GO:0044444;GO:0005634;GO:0009986;GO:0099503;GO:0032994;GO:0031983;GO:0031982;GO:0031988;GO:0005737;GO:0097708;GO:0031410;GO:0005623;GO:0030139;GO:0005886;GO:0016020;GO:1903561;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;endoplasmic reticulum;endoplasmic reticulum lumen;secretory granule lumen;intracellular part;extracellular region part;organelle part;vacuole;cell part;cell periphery;extracellular space;extracellular exosome;intracellular organelle lumen;early endosome;endocytic vesicle lumen;cytoplasmic, membrane-bounded vesicle;very-low-density lipoprotein particle;high-density lipoprotein particle;discoidal high-density lipoprotein particle;spherical high-density lipoprotein particle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;blood microparticle;cytoplasmic vesicle part;endoplasmic reticulum part;secretory granule;triglyceride-rich lipoprotein particle;lipoprotein particle;cytoplasmic membrane-bounded vesicle lumen;endosome;membrane-enclosed lumen;intracellular organelle;intracellular;membrane-bounded organelle;organelle;chylomicron;endomembrane system;intracellular organelle part;cytoplasmic part;nucleus;cell surface;secretory vesicle;protein-lipid complex;vesicle lumen;vesicle;membrane-bounded vesicle;cytoplasm;intracellular vesicle;cytoplasmic vesicle;cell;endocytic vesicle;plasma membrane;membrane;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 3;4;5;5;3;2;2;5;2;3;3;4;4;5;6;5;5;4;5;5;3;4;3;5;3;4;4;4;4;4;5;4;2;3;3;3;2;4;3;3;4;5;3;6;3;4;4;5;4;4;5;2;6;3;2;3;2;1;2; GO:0098772;GO:0034191;GO:0071813;GO:0005488;GO:0034190;GO:0008289;GO:0017127;GO:0050997;GO:0005548;GO:0005319;GO:0030234;GO:0022892;GO:0019899;GO:0004857;GO:0008035;GO:0005215;GO:0005515;GO:0005102;GO:0008047;GO:0070405;GO:0033218;GO:0070653;GO:0045499;GO:0003674;GO:0097159;GO:0005543;GO:0043168;GO:0043169;GO:0042277;GO:0043167;GO:0042802;GO:0071814;GO:0032934;GO:0036094;GO:0005496;GO:0044877;GO:0015485;GO:0015248;GO:0055102;GO:0070325;GO:0001540;GO:0043178;GO:0060228;GO:0031210; molecular function regulator;apolipoprotein A-I receptor binding;lipoprotein particle binding;binding;apolipoprotein receptor binding;lipid binding;cholesterol transporter activity;quaternary ammonium group binding;phospholipid transporter activity;lipid transporter activity;enzyme regulator activity;substrate-specific transporter activity;enzyme binding;enzyme inhibitor activity;high-density lipoprotein particle binding;transporter activity;protein binding;receptor binding;enzyme activator activity;ammonium ion binding;amide binding;high-density lipoprotein particle receptor binding;chemorepellent activity;molecular_function;organic cyclic compound binding;phospholipid binding;anion binding;cation binding;peptide binding;ion binding;identical protein binding;protein-lipid complex binding;sterol binding;small molecule binding;steroid binding;macromolecular complex binding;cholesterol binding;sterol transporter activity;lipase inhibitor activity;lipoprotein particle receptor binding;beta-amyloid binding;alcohol binding;phosphatidylcholine-sterol O-acyltransferase activator activity;phosphatidylcholine binding; 2;6;5;2;5;3;6;3;5;4;3;3;4;4;6;2;3;4;4;5;3;6;2;1;3;4;4;4;4;3;4;4;5;3;4;3;6;5;5;5;5;4;5;4; K08757 map03320;map04975;map04977;map05143; PPAR signaling pathway;Fat digestion and absorption;Vitamin digestion and absorption;African trypanosomiasis; IPR000074; Apolipoprotein A/E; extracellular Q9UKL3 CASP8-associated protein 2 OS=Homo sapiens OX=9606 GN=CASP8AP2 PE=1 SV=1 - [C8AP2_HUMAN] 1.007 1.142 0.684 1.354 1.145 0.994 0.88178634 nan 1.182532751 nan 0.598949212 nan 0.868122271 nan GO:0080090;GO:0019222;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0010604;GO:0043067;GO:0009612;GO:0044093;GO:0043281;GO:0043280;GO:0060255;GO:0030162;GO:2001141;GO:0046483;GO:0044700;GO:0009605;GO:0019538;GO:0010468;GO:0019438;GO:0009892;GO:0009890;GO:0071260;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0052547;GO:0019219;GO:0065007;GO:0043085;GO:0065009;GO:0071214;GO:0018130;GO:0007049;GO:0050790;GO:0009889;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0051604;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0023052;GO:0048519;GO:0034645;GO:0010950;GO:0044699;GO:0009893;GO:0006139;GO:0008625;GO:0051246;GO:0051247;GO:0032270;GO:0051336;GO:0071496;GO:0009628;GO:0031323;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0048518;GO:0006508;GO:0016485;GO:0036337;GO:0032268;GO:0051253;GO:0051252;GO:0043170;GO:0045862;GO:0006919;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0097190;GO:0097191;GO:2001056;GO:0090304;GO:0010942;GO:0008219;GO:0010941;GO:0097202;GO:2000116;GO:0042981;GO:2000112;GO:0031638;GO:0050789;GO:0043065;GO:0071704;GO:0010467;GO:0043068;GO:0045934;GO:0044267;GO:0052548;GO:0006915;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007154;GO:0010952;GO:0044238;GO:0051345;GO:0044237;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;regulation of programmed cell death;response to mechanical stimulus;positive regulation of molecular function;regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;regulation of macromolecule metabolic process;regulation of proteolysis;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;response to external stimulus;protein metabolic process;regulation of gene expression;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;cellular response to mechanical stimulus;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of peptidase activity;regulation of nucleobase-containing compound metabolic process;biological regulation;positive regulation of catalytic activity;regulation of molecular function;cellular response to abiotic stimulus;heterocycle biosynthetic process;cell cycle;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;programmed cell death;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;protein maturation;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of biological process;cellular macromolecule biosynthetic process;positive regulation of endopeptidase activity;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;extrinsic apoptotic signaling pathway via death domain receptors;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of hydrolase activity;cellular response to external stimulus;response to abiotic stimulus;regulation of cellular metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;positive regulation of biological process;proteolysis;protein processing;Fas signaling pathway;regulation of cellular protein metabolic process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of proteolysis;activation of cysteine-type endopeptidase activity involved in apoptotic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;positive regulation of cysteine-type endopeptidase activity;nucleic acid metabolic process;positive regulation of cell death;cell death;regulation of cell death;activation of cysteine-type endopeptidase activity;regulation of cysteine-type endopeptidase activity;regulation of apoptotic process;regulation of cellular macromolecule biosynthetic process;zymogen activation;regulation of biological process;positive regulation of apoptotic process;organic substance metabolic process;gene expression;positive regulation of programmed cell death;negative regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of endopeptidase activity;apoptotic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell communication;positive regulation of peptidase activity;primary metabolic process;positive regulation of hydrolase activity;cellular metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;5;5;4;3;4;4;5;4;4;7;7;4;6;6;4;3;3;4;5;5;3;4;5;3;7;4;4;6;5;2;5;3;4;5;4;4;4;3;5;1;2;5;5;5;5;2;6;5;6;5;6;4;4;2;2;5;8;2;3;4;7;5;5;5;5;4;3;4;2;4;7;7;2;5;6;6;5;5;5;4;6;7;5;5;4;4;5;6;9;5;4;4;4;8;8;6;6;7;2;6;3;5;5;5;5;7;6;6;3;5;3;4;4;4;7;3;6;3;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016605;GO:0016604;GO:0005654;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005739;GO:0044451;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;PML body;nuclear body;nucleoplasm;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;mitochondrion;nucleoplasm part;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;3;2;7;6;5;3;4;4;5;5;5;2;2;1;4; GO:0098772;GO:1901363;GO:0043028;GO:0003714;GO:0032184;GO:0005126;GO:0005123;GO:0032182;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0061134;GO:0000989;GO:0000988;GO:0032813;GO:0008656;GO:0097159;GO:0003712;GO:0032183;GO:0005515;GO:0005102;GO:0008047;GO:0030234;GO:0016504;GO:0016505; molecular function regulator;heterocyclic compound binding;cysteine-type endopeptidase regulator activity involved in apoptotic process;transcription corepressor activity;SUMO polymer binding;cytokine receptor binding;death receptor binding;ubiquitin-like protein binding;molecular_function;binding;nucleic acid binding;DNA binding;peptidase regulator activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;tumor necrosis factor receptor superfamily binding;cysteine-type endopeptidase activator activity involved in apoptotic process;organic cyclic compound binding;transcription cofactor activity;SUMO binding;protein binding;receptor binding;enzyme activator activity;enzyme regulator activity;peptidase activator activity;peptidase activator activity involved in apoptotic process; 2;3;4;5;6;5;7;4;1;2;4;5;4;3;2;6;5;3;4;5;3;4;4;3;5;6; IPR009057; Homeobox domain-like; nucleus P41162 ETS translocation variant 3 OS=Homo sapiens OX=9606 GN=ETV3 PE=1 SV=2 - [ETV3_HUMAN] 0.724 1.356 0.686 0.965 1.586 0.895 0.533923304 nan 0.608448928 nan 0.505899705 nan 0.564312736 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0051716;GO:0048869;GO:0071310;GO:0048519;GO:0042127;GO:0060255;GO:2001141;GO:0010033;GO:0046483;GO:0019438;GO:0034645;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0006357;GO:0065007;GO:0006366;GO:0018130;GO:0034097;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0071345;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0070887;GO:0044699;GO:0006139;GO:0032502;GO:0008285;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0051252;GO:0031326;GO:0031323;GO:0090304;GO:0097011;GO:2000112;GO:0071704;GO:0010467;GO:0097012;GO:0010468;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0042221;GO:0044238;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;cellular developmental process;cellular response to organic substance;negative regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;aromatic compound biosynthetic process;cellular macromolecule biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;response to cytokine;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular response to chemical stimulus;single-organism process;nucleobase-containing compound metabolic process;developmental process;negative regulation of cell proliferation;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of RNA metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular response to granulocyte macrophage colony-stimulating factor stimulus;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;response to granulocyte macrophage colony-stimulating factor;regulation of gene expression;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;response to chemical;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 4;3;5;4;3;4;5;2;4;4;6;4;4;5;5;3;4;2;7;4;4;7;2;7;5;5;4;3;1;2;5;5;5;6;2;6;5;6;6;5;4;4;4;2;4;2;4;3;2;4;7;5;5;4;5;7;6;3;5;6;5;5;3;3;5;3;4;3;3;3;3; GO:0031974;GO:0031981;GO:0000790;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0090571;GO:0043229;GO:0000228;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0090568;GO:0044454;GO:0044451;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0000785;GO:0043226;GO:0005694;GO:0017053;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;nuclear chromatin;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;RNA polymerase II transcription repressor complex;intracellular organelle;nuclear chromosome;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;nuclear transcriptional repressor complex;nuclear chromosome part;nucleoplasm part;cell part;cell;intracellular;non-membrane-bounded organelle;chromatin;organelle;chromosome;transcriptional repressor complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;4;3;4;4;3;4;3;4;2;6;3;5;3;5;3;5;5;5;5;2;2;3;3;3;2;5;4;2;1;4; GO:0001071;GO:1901363;GO:0001067;GO:0044212;GO:0001012;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000981;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:1990837;GO:0003690;GO:0001227;GO:0000977;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 2;3;5;7;8;1;2;4;5;4;6;3;8;6;7;6;5;9;3; K09433 IPR000418;IPR032929;IPR011991; Ets domain;ETS translocation variant 3;Winged helix-turn-helix DNA-binding domain; nucleus Hs5729814 326.0 K [K] Transcription; P49638 Alpha-tocopherol transfer protein OS=Homo sapiens OX=9606 GN=TTPA PE=1 SV=1 - [TTPA_HUMAN] 1.266 0.643 1.236 0.799 0.904 1.772 1.968895801 nan 0.883849558 nan 1.922239502 nan 1.960176991 nan GO:0006775;GO:0048468;GO:0044281;GO:0098771;GO:1901360;GO:0044710;GO:0000003;GO:0048869;GO:0060856;GO:0010721;GO:0048519;GO:0019725;GO:0006766;GO:0060548;GO:0003006;GO:0046483;GO:0044702;GO:0044707;GO:0031667;GO:0048878;GO:0048568;GO:0050789;GO:0051180;GO:0006885;GO:0065007;GO:0065008;GO:0006629;GO:0050793;GO:0006810;GO:0090212;GO:0090210;GO:0050794;GO:0008150;GO:0008152;GO:0009268;GO:0051234;GO:0044767;GO:0046909;GO:0050896;GO:1901615;GO:0050801;GO:0030154;GO:0009790;GO:0009792;GO:0051453;GO:0051452;GO:0044699;GO:0001701;GO:0060284;GO:0048513;GO:0043009;GO:0032502;GO:0032501;GO:0048608;GO:0009628;GO:0009987;GO:0006873;GO:0045596;GO:0045595;GO:0030003;GO:0055080;GO:0055082;GO:0001892;GO:0001890;GO:0051093;GO:0042360;GO:0048731;GO:0009991;GO:0061458;GO:0042592;GO:0045851;GO:0008219;GO:0010941;GO:0007275;GO:0030641;GO:0009636;GO:0071704;GO:0009605;GO:0007584;GO:0022414;GO:0044765;GO:0044763;GO:0055067;GO:0042221;GO:0051179;GO:1902578;GO:0044238;GO:0030004;GO:0048856;GO:0044237;GO:0048523; fat-soluble vitamin metabolic process;cell development;small molecule metabolic process;inorganic ion homeostasis;organic cyclic compound metabolic process;single-organism metabolic process;reproduction;cellular developmental process;establishment of blood-brain barrier;negative regulation of cell development;negative regulation of biological process;cellular homeostasis;vitamin metabolic process;negative regulation of cell death;developmental process involved in reproduction;heterocycle metabolic process;single organism reproductive process;single-multicellular organism process;response to nutrient levels;chemical homeostasis;embryonic organ development;regulation of biological process;vitamin transport;regulation of pH;biological regulation;regulation of biological quality;lipid metabolic process;regulation of developmental process;transport;negative regulation of establishment of blood-brain barrier;regulation of establishment of blood-brain barrier;regulation of cellular process;biological_process;metabolic process;response to pH;establishment of localization;single-organism developmental process;intermembrane transport;response to stimulus;organic hydroxy compound metabolic process;ion homeostasis;cell differentiation;embryo development;embryo development ending in birth or egg hatching;regulation of intracellular pH;intracellular pH reduction;single-organism process;in utero embryonic development;regulation of cell development;animal organ development;chordate embryonic development;developmental process;multicellular organismal process;reproductive structure development;response to abiotic stimulus;cellular process;cellular ion homeostasis;negative regulation of cell differentiation;regulation of cell differentiation;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;embryonic placenta development;placenta development;negative regulation of developmental process;vitamin E metabolic process;system development;response to extracellular stimulus;reproductive system development;homeostatic process;pH reduction;cell death;regulation of cell death;multicellular organism development;regulation of cellular pH;response to toxic substance;organic substance metabolic process;response to external stimulus;response to nutrient;reproductive process;single-organism transport;single-organism cellular process;monovalent inorganic cation homeostasis;response to chemical;localization;single-organism localization;primary metabolic process;cellular monovalent inorganic cation homeostasis;anatomical structure development;cellular metabolic process;negative regulation of cellular process; 6;4;4;7;4;3;2;4;5;5;2;4;5;4;3;4;3;3;5;5;4;2;5;9;2;3;4;3;4;6;6;3;1;2;4;3;3;5;2;4;6;5;5;6;10;11;2;8;5;4;7;2;2;4;3;2;6;4;4;7;7;5;4;4;3;4;4;4;5;4;10;4;4;4;9;4;3;3;4;2;4;3;8;3;2;3;3;8;3;3;3; GO:0005773;GO:0043231;GO:0005829;GO:0044424;GO:0043229;GO:0043227;GO:0012505;GO:0044444;GO:0005770;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0005768; vacuole;intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;membrane-bounded organelle;endomembrane system;cytoplasmic part;late endosome;cytoplasm;cell part;cell;intracellular;organelle;cellular_component;endosome; 5;4;5;3;3;3;3;4;5;4;2;2;3;2;1;4; GO:1901363;GO:0005543;GO:0005546;GO:0043325;GO:0003674;GO:0005488;GO:1902936;GO:0043168;GO:1901981;GO:0097159;GO:0043167;GO:0005215;GO:0008289;GO:0008431;GO:0035091;GO:0019842;GO:0036094; heterocyclic compound binding;phospholipid binding;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;molecular_function;binding;phosphatidylinositol bisphosphate binding;anion binding;phosphatidylinositol phosphate binding;organic cyclic compound binding;ion binding;transporter activity;lipid binding;vitamin E binding;phosphatidylinositol binding;vitamin binding;small molecule binding; 3;4;8;8;1;2;7;4;6;3;3;2;3;4;5;4;3; IPR001251;IPR001071;IPR011074; CRAL-TRIO lipid binding domain;Cellular retinaldehyde binding/alpha-tocopherol transport;CRAL/TRIO, N-terminal domain; cytosol Hs4507723 573.0 I [I] Lipid transport and metabolism; A0A087WSX0 Immunoglobulin lambda variable 5-45 OS=Homo sapiens OX=9606 GN=IGLV5-45 PE=3 SV=1 - [LV545_HUMAN] 1.619 0.87 0.647 1.47 0.799 0.916 1.86091954 0.145669369 1.83979975 0.038251237 0.743678161 0.073846337 1.146433041 nan K06553 IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular O95153 Peripheral-type benzodiazepine receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TSPOAP1 PE=1 SV=2 - [RIMB1_HUMAN] 0.954 0.973 0.894 1.357 0.928 1.63 0.980472765 nan 1.462284483 nan 0.918807811 nan 1.756465517 nan GO:0099643;GO:0007269;GO:0006865;GO:0046717;GO:0006820;GO:0051641;GO:0099531;GO:0044699;GO:0051649;GO:0071705;GO:0065007;GO:0071702;GO:0023052;GO:0001505;GO:0006836;GO:0006810;GO:0015849;GO:0006811;GO:0009987;GO:0015711;GO:0023061;GO:0099537;GO:0014047;GO:0044765;GO:0008150;GO:0032940;GO:0007268;GO:0007267;GO:0007154;GO:0051234;GO:0051179;GO:1902578;GO:0046942;GO:0044700;GO:0046903;GO:0065008;GO:0098916;GO:0044763;GO:0006835;GO:0099536; signal release from synapse;neurotransmitter secretion;amino acid transport;acid secretion;anion transport;cellular localization;presynaptic process involved in synaptic transmission;single-organism process;establishment of localization in cell;nitrogen compound transport;biological regulation;organic substance transport;signaling;regulation of neurotransmitter levels;neurotransmitter transport;transport;organic acid transport;ion transport;cellular process;organic anion transport;signal release;trans-synaptic signaling;glutamate secretion;single-organism transport;biological_process;secretion by cell;synaptic transmission;cell-cell signaling;cell communication;establishment of localization;localization;single-organism localization;carboxylic acid transport;single organism signaling;secretion;regulation of biological quality;anterograde trans-synaptic signaling;single-organism cellular process;dicarboxylic acid transport;synaptic signaling; 6;3;6;6;6;3;2;2;4;5;2;5;2;4;5;4;5;5;2;6;5;6;5;4;1;4;8;4;4;3;2;3;6;3;5;3;7;3;7;5; GO:0043227;GO:0043226;GO:0005737;GO:0005739;GO:0097458;GO:0044456;GO:0043231;GO:0005829;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0098793;GO:0044424;GO:0045202; membrane-bounded organelle;organelle;cytoplasm;mitochondrion;neuron part;synapse part;intracellular membrane-bounded organelle;cytosol;cell part;intracellular organelle;cell;intracellular;cellular_component;cytoplasmic part;presynapse;intracellular part;synapse; 3;2;4;5;3;2;4;5;2;3;2;3;1;4;3;3;2; GO:0030156;GO:0003674;GO:0005488;GO:0005515;GO:0005102; benzodiazepine receptor binding;molecular_function;binding;protein binding;receptor binding; 5;1;2;3;4; K19922 IPR001452;IPR003961;IPR013783;IPR011511;IPR035517; SH3 domain;Fibronectin type III;Immunoglobulin-like fold;Variant SH3 domain;RIMS-binding protein 1; nucleus Hs4758956 3687.0 TZ [T] Signal transduction mechanisms;[Z] Cytoskeleton; P20848 Putative alpha-1-antitrypsin-related protein OS=Homo sapiens OX=9606 GN=SERPINA2 PE=1 SV=1 - [A1ATR_HUMAN] 1.019 0.874 1.26 1.209 0.725 1.096 1.16590389 0.566406234 1.667586207 0.059848089 1.441647597 0.222586364 1.511724138 0.090501548 GO:0009892;GO:0080090;GO:0019222;GO:0031324;GO:0031323;GO:0050789;GO:0044267;GO:0051248;GO:0010605;GO:0051346;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0050790;GO:0052547;GO:0052548;GO:0009987;GO:0050794;GO:0008150;GO:0008152;GO:0006508;GO:0010951;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0060255;GO:0044237;GO:0043170;GO:0019538;GO:0030162;GO:0045861;GO:0048523; negative regulation of metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of biological process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;regulation of catalytic activity;regulation of peptidase activity;regulation of endopeptidase activity;cellular process;regulation of cellular process;biological_process;metabolic process;proteolysis;negative regulation of endopeptidase activity;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of macromolecule metabolic process;cellular metabolic process;macromolecule metabolic process;protein metabolic process;regulation of proteolysis;negative regulation of proteolysis;negative regulation of cellular process; 3;4;3;4;4;2;5;5;4;6;4;5;5;3;7;2;4;2;3;4;6;7;2;3;1;2;5;8;5;3;5;5;4;3;4;4;6;6;3; GO:0043226;GO:0005623;GO:0043227;GO:0005783;GO:0005737;GO:0005615;GO:0012505;GO:0043231;GO:0005622;GO:0044464;GO:0043229;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421; organelle;cell;membrane-bounded organelle;endoplasmic reticulum;cytoplasm;extracellular space;endomembrane system;intracellular membrane-bounded organelle;intracellular;cell part;intracellular organelle;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part; 2;2;3;4;4;3;3;4;3;2;3;1;4;2;3;2; GO:0030414;GO:0003674;GO:0004857;GO:0098772;GO:0061134;GO:0061135;GO:0004866;GO:0030234;GO:0004867; peptidase inhibitor activity;molecular_function;enzyme inhibitor activity;molecular function regulator;peptidase regulator activity;endopeptidase regulator activity;endopeptidase inhibitor activity;enzyme regulator activity;serine-type endopeptidase inhibitor activity; 5;1;4;2;4;5;6;3;7; K04525 IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; extracellular Hs5453896 874.0 V [V] Defense mechanisms; Q9BQI6 SMC5-SMC6 complex localization factor protein 1 OS=Homo sapiens OX=9606 GN=SLF1 PE=1 SV=2 - [SLF1_HUMAN] 1.419 0.741 0.954 1.174 0.885 0.859 1.914979757 0.086526093 1.326553672 0.336229453 1.287449393 0.281965366 0.970621469 0.962172392 GO:0008104;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0071840;GO:0051716;GO:0010604;GO:0070727;GO:0033043;GO:0034088;GO:0048518;GO:0033036;GO:0051054;GO:0006282;GO:0051052;GO:0006281;GO:0060255;GO:2001020;GO:2001022;GO:0046483;GO:0010638;GO:0051783;GO:0051781;GO:0033554;GO:0045840;GO:0022607;GO:0009893;GO:0034091;GO:0034086;GO:0006807;GO:0007064;GO:0007067;GO:0050789;GO:0007063;GO:0007062;GO:0090068;GO:0007346;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0051130;GO:0034093;GO:0045876;GO:0034613;GO:0051785;GO:0044710;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0007059;GO:0043254;GO:0006302;GO:0050896;GO:0080135;GO:2000781;GO:0045739;GO:2001252;GO:0033044;GO:0033045;GO:0033047;GO:0070271;GO:0000280;GO:0051128;GO:0034641;GO:1990166;GO:0044699;GO:0006139;GO:0010564;GO:0009987;GO:0031334;GO:0006974;GO:1903047;GO:0051984;GO:0051983;GO:0007049;GO:0000819;GO:0098813;GO:0043170;GO:2000779;GO:0033365;GO:0080134;GO:0034502;GO:0043933;GO:0031325;GO:0031323;GO:0090304;GO:0022402;GO:0051302;GO:0051301;GO:0071822;GO:0071704;GO:0045931;GO:0045935;GO:0000278;GO:0019219;GO:0006725;GO:0006461;GO:0007088;GO:0044763;GO:0051171;GO:0051173;GO:0034182;GO:0034184;GO:0051179;GO:0051641;GO:0006996;GO:0044238;GO:0000070;GO:0051276;GO:0051726;GO:0045787;GO:0044237;GO:0044087;GO:1902589;GO:0044085;GO:0048285;GO:0006259;GO:0044089;GO:0048522; protein localization;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of macromolecule metabolic process;cellular macromolecule localization;regulation of organelle organization;maintenance of mitotic sister chromatid cohesion;positive regulation of biological process;macromolecule localization;positive regulation of DNA metabolic process;regulation of DNA repair;regulation of DNA metabolic process;DNA repair;regulation of macromolecule metabolic process;regulation of response to DNA damage stimulus;positive regulation of response to DNA damage stimulus;heterocycle metabolic process;positive regulation of organelle organization;regulation of nuclear division;positive regulation of cell division;cellular response to stress;positive regulation of mitotic nuclear division;cellular component assembly;positive regulation of metabolic process;regulation of maintenance of sister chromatid cohesion;maintenance of sister chromatid cohesion;nitrogen compound metabolic process;mitotic sister chromatid cohesion;mitotic nuclear division;regulation of biological process;regulation of sister chromatid cohesion;sister chromatid cohesion;positive regulation of cell cycle process;regulation of mitotic cell cycle;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;positive regulation of cellular component organization;positive regulation of maintenance of sister chromatid cohesion;positive regulation of sister chromatid cohesion;cellular protein localization;positive regulation of nuclear division;single-organism metabolic process;regulation of cellular process;response to stress;biological_process;metabolic process;chromosome segregation;regulation of protein complex assembly;double-strand break repair;response to stimulus;regulation of cellular response to stress;positive regulation of double-strand break repair;positive regulation of DNA repair;positive regulation of chromosome organization;regulation of chromosome organization;regulation of sister chromatid segregation;regulation of mitotic sister chromatid segregation;protein complex biogenesis;nuclear division;regulation of cellular component organization;cellular nitrogen compound metabolic process;protein localization to site of double-strand break;single-organism process;nucleobase-containing compound metabolic process;regulation of cell cycle process;cellular process;positive regulation of protein complex assembly;cellular response to DNA damage stimulus;mitotic cell cycle process;positive regulation of chromosome segregation;regulation of chromosome segregation;cell cycle;sister chromatid segregation;nuclear chromosome segregation;macromolecule metabolic process;regulation of double-strand break repair;protein localization to organelle;regulation of response to stress;protein localization to chromosome;macromolecular complex subunit organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;regulation of cell division;cell division;protein complex subunit organization;organic substance metabolic process;positive regulation of mitotic cell cycle;positive regulation of nucleobase-containing compound metabolic process;mitotic cell cycle;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;protein complex assembly;regulation of mitotic nuclear division;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;regulation of maintenance of mitotic sister chromatid cohesion;positive regulation of maintenance of mitotic sister chromatid cohesion;localization;cellular localization;organelle organization;primary metabolic process;mitotic sister chromatid segregation;chromosome organization;regulation of cell cycle;positive regulation of cell cycle;cellular metabolic process;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;organelle fission;DNA metabolic process;positive regulation of cellular component biogenesis;positive regulation of cellular process; 4;4;3;3;3;2;3;4;4;5;6;2;3;5;5;5;4;4;5;4;4;5;5;4;4;6;4;3;6;5;3;6;5;2;6;5;5;5;4;3;5;2;4;4;6;5;5;5;3;3;3;1;2;4;4;5;2;4;6;5;6;6;5;6;4;6;4;4;8;2;4;5;2;4;5;5;4;4;4;5;5;4;6;6;4;7;4;4;4;5;4;4;4;5;3;5;5;5;5;4;5;6;3;4;4;7;7;2;3;4;3;6;5;4;4;3;3;4;3;5;5;3;3; GO:0005815;GO:0043234;GO:0043231;GO:0043232;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0000786;GO:0005622;GO:0043227;GO:0005856;GO:0044430;GO:0035861;GO:0044446;GO:0044815;GO:0042405;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043228;GO:0000785;GO:0016234;GO:0005813;GO:0043226;GO:0005694;GO:0015630;GO:0032991;GO:0032993;GO:0005575; microtubule organizing center;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;nucleosome;intracellular;membrane-bounded organelle;cytoskeleton;cytoskeletal part;site of double-strand break;intracellular organelle part;DNA packaging complex;nuclear inclusion body;cytoplasm;nucleus;cell part;cell;non-membrane-bounded organelle;chromatin;inclusion body;centrosome;organelle;chromosome;microtubule cytoskeleton;macromolecular complex;protein-DNA complex;cellular_component; 5;3;4;4;4;3;4;2;3;4;3;3;5;4;5;3;4;5;4;5;2;2;3;3;4;5;2;5;6;2;3;1; GO:0044877;GO:0003674;GO:0005488;GO:0019899;GO:0032403;GO:0031625;GO:0005515;GO:0044389; macromolecular complex binding;molecular_function;binding;enzyme binding;protein complex binding;ubiquitin protein ligase binding;protein binding;ubiquitin-like protein ligase binding; 3;1;2;4;4;6;3;5; IPR001357;IPR002110;IPR020683; BRCT domain;Ankyrin repeat;Ankyrin repeat-containing domain; nucleus Hs14150037 870.0 R [R] General function prediction only; Q9BZ72 Membrane-associated phosphatidylinositol transfer protein 2 OS=Homo sapiens OX=9606 GN=PITPNM2 PE=1 SV=1 - [PITM2_HUMAN] 0.511 0.478 2.418 0.457 0.533 1.524 1.069037657 0.738731343 0.857410882 0.492685541 5.058577406 0.022127169 2.859287054 0.41692362 GO:0006810;GO:0008150;GO:0008152;GO:0051234;GO:0051179; transport;biological_process;metabolic process;establishment of localization;localization; 4;1;2;3;2; GO:0043229;GO:0043227;GO:0043226;GO:0031224;GO:0016021;GO:0016020;GO:0012505;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044425; intracellular organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;integral component of membrane;membrane;endomembrane system;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part;membrane part; 3;3;2;3;4;2;3;4;2;2;3;1;3;2; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872;GO:0008289; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding;lipid binding; 1;2;4;3;6;5;3; IPR023214;IPR004177;IPR023393;IPR001666;IPR031315; HAD-like domain;DDHD domain;START-like domain;Phosphatidylinositol transfer protein;LNS2/PITP; plasma membrane Hs20553175 2801.0 IT [I] Lipid transport and metabolism;[T] Signal transduction mechanisms; Q6VAB6 Kinase suppressor of Ras 2 OS=Homo sapiens OX=9606 GN=KSR2 PE=1 SV=2 - [KSR2_HUMAN] 0.836 0.765 1.826 0.736 0.851 0.859 1.092810458 nan 0.864864865 nan 2.386928105 nan 1.009400705 nan GO:0007165;GO:0035556;GO:0050789;GO:0044699;GO:0051716;GO:0065007;GO:0009987;GO:0050794;GO:0008150;GO:0023052;GO:0007154;GO:0044700;GO:0050896;GO:0044763; signal transduction;intracellular signal transduction;regulation of biological process;single-organism process;cellular response to stimulus;biological regulation;cellular process;regulation of cellular process;biological_process;signaling;cell communication;single organism signaling;response to stimulus;single-organism cellular process; 4;5;2;2;3;2;2;3;1;2;4;3;2;3; GO:0005737;GO:0016020;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;membrane;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;2;3;1;3; GO:0035639;GO:1901363;GO:0003674;GO:0001883;GO:0000166;GO:0001882;GO:0043169;GO:0032549;GO:0043167;GO:0004674;GO:0016740;GO:1901265;GO:0004672;GO:0017076;GO:0046872;GO:0005524;GO:0043168;GO:0016301;GO:0036094;GO:0003824;GO:0032555;GO:0030554;GO:0016773;GO:0016772;GO:0097367;GO:0032559;GO:0097159;GO:0032550;GO:0032553;GO:0005488; purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;purine nucleoside binding;nucleotide binding;nucleoside binding;cation binding;ribonucleoside binding;ion binding;protein serine/threonine kinase activity;transferase activity;nucleoside phosphate binding;protein kinase activity;purine nucleotide binding;metal ion binding;ATP binding;anion binding;kinase activity;small molecule binding;catalytic activity;purine ribonucleotide binding;adenyl nucleotide binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;carbohydrate derivative binding;adenyl ribonucleotide binding;organic cyclic compound binding;purine ribonucleoside binding;ribonucleotide binding;binding; 5;3;1;5;4;4;4;5;3;7;3;4;6;5;5;6;4;5;3;2;5;6;5;4;3;6;3;6;4;2; K18529 map04014; Ras signaling pathway; IPR002219;IPR011009;IPR000719;IPR001245;IPR008271;IPR025561; Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;Protein kinase-like domain;Protein kinase domain;Serine-threonine/tyrosine-protein kinase, catalytic domain;Serine/threonine-protein kinase, active site;Kinase suppressor of RAS, SAM-like domain; cytosol, nucleus Hs22057382 1149.0 T [T] Signal transduction mechanisms; A0A0C4DH33 Immunoglobulin heavy variable 1-24 OS=Homo sapiens OX=9606 GN=IGHV1-24 PE=3 SV=1 - [HV124_HUMAN] 1.03 1.266 0.846 1.122 1.03 0.868 0.813586098 nan 1.089320388 nan 0.668246445 nan 0.842718447 nan IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q96M93 Adenosine deaminase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAD1 PE=2 SV=1 - [ADAD1_HUMAN] 1.025 0.973 1.052 0.853 1.023 1.783 1.05344296 nan 0.833822092 nan 1.081192189 nan 1.742913001 nan GO:0008152;GO:0044237;GO:0030154;GO:0048468;GO:0019953;GO:0090304;GO:0006807;GO:0043170;GO:0044699;GO:0006139;GO:0003006;GO:0048869;GO:0010467;GO:0071704;GO:0007276;GO:0051704;GO:0048515;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0044238;GO:0009987;GO:0006725;GO:0044260;GO:0007281;GO:0007283;GO:0008150;GO:0022412;GO:0048232;GO:0000003;GO:0016070;GO:0044767;GO:0044703;GO:0044702;GO:0046483;GO:0044707;GO:0022414;GO:0048856;GO:0034641;GO:0007275;GO:0044763;GO:0007286;GO:1901360;GO:0006396; metabolic process;cellular metabolic process;cell differentiation;cell development;sexual reproduction;nucleic acid metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;single-organism process;nucleobase-containing compound metabolic process;developmental process involved in reproduction;cellular developmental process;gene expression;organic substance metabolic process;gamete generation;multi-organism process;spermatid differentiation;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;primary metabolic process;cellular process;cellular aromatic compound metabolic process;cellular macromolecule metabolic process;germ cell development;spermatogenesis;biological_process;cellular process involved in reproduction in multicellular organism;male gamete generation;reproduction;RNA metabolic process;single-organism developmental process;multi-organism reproductive process;single organism reproductive process;heterocycle metabolic process;single-multicellular organism process;reproductive process;anatomical structure development;cellular nitrogen compound metabolic process;multicellular organism development;single-organism cellular process;spermatid development;organic cyclic compound metabolic process;RNA processing; 2;3;5;4;3;5;3;4;2;4;3;4;5;3;4;2;4;2;2;3;3;3;2;4;4;4;6;1;4;5;2;5;3;3;3;4;3;2;3;4;4;3;5;4;6; GO:0043229;GO:0043227;GO:0043226;GO:0005623;GO:0005634;GO:0043231;GO:0044464;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;cell;nucleus;intracellular membrane-bounded organelle;cell part;intracellular;cellular_component;intracellular part; 3;3;2;2;5;4;2;3;1;3; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0019239;GO:0016787;GO:0004000;GO:0003824;GO:0097159;GO:0016810;GO:0016814;GO:0003723; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;deaminase activity;hydrolase activity;adenosine deaminase activity;catalytic activity;organic cyclic compound binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;RNA binding; 1;2;4;3;3;3;4;2;3;4;5;5; IPR014720;IPR002466; Double-stranded RNA-binding domain;Adenosine deaminase/editase; cytosol Hs21245124 1195.0 A [A] RNA processing and modification; A0A075B6S2 Immunoglobulin kappa variable 2D-29 OS=Homo sapiens OX=9606 GN=IGKV2D-29 PE=3 SV=1 - [KVD29_HUMAN] 0.987 0.829 1.334 0.955 0.827 0.909 1.190591074 0.005992455 1.1547763 0.15672607 1.609167672 0.000147417 1.099153567 0.061268458 IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9Y5E3 Protocadherin beta-6 OS=Homo sapiens OX=9606 GN=PCDHB6 PE=2 SV=1 - [PCDB6_HUMAN] 0.828 1.088 0.9 1.141 1.153 1.514 0.761029412 nan 0.989592368 nan 0.827205882 nan 1.313096271 nan GO:0007416;GO:0022607;GO:0016339;GO:0007268;GO:0007267;GO:0023052;GO:0007275;GO:0044699;GO:0016043;GO:0044085;GO:0071840;GO:0032502;GO:0032501;GO:0098609;GO:0050808;GO:0009987;GO:0044767;GO:0008150;GO:0007155;GO:0007154;GO:0007156;GO:0098742;GO:0044700;GO:0022610;GO:0044707;GO:0007399;GO:0048856;GO:0044763;GO:0098916;GO:0048731;GO:0099536;GO:0099537; synapse assembly;cellular component assembly;calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;synaptic transmission;cell-cell signaling;signaling;multicellular organism development;single-organism process;cellular component organization;cellular component biogenesis;cellular component organization or biogenesis;developmental process;multicellular organismal process;cell-cell adhesion;synapse organization;cellular process;single-organism developmental process;biological_process;cell adhesion;cell communication;homophilic cell adhesion via plasma membrane adhesion molecules;cell-cell adhesion via plasma-membrane adhesion molecules;single organism signaling;biological adhesion;single-multicellular organism process;nervous system development;anatomical structure development;single-organism cellular process;anterograde trans-synaptic signaling;system development;synaptic signaling;trans-synaptic signaling; 5;4;6;8;4;2;4;2;3;3;2;2;2;4;4;2;3;1;3;4;6;5;3;2;3;5;3;3;7;4;5;6; GO:0031224;GO:0071944;GO:0031226;GO:0016021;GO:0016020;GO:0044425;GO:0044459;GO:0005887;GO:0005886;GO:0044464;GO:0005623;GO:0005575; intrinsic component of membrane;cell periphery;intrinsic component of plasma membrane;integral component of membrane;membrane;membrane part;plasma membrane part;integral component of plasma membrane;plasma membrane;cell part;cell;cellular_component; 3;3;4;4;2;2;3;4;3;2;2;1; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding; 1;2;4;3;6;5; K16494 IPR002126;IPR020894;IPR015919;IPR032455;IPR013164; Cadherin;Cadherin conserved site;Cadherin-like;Cadherin, cytoplasmic C-terminal domain;Cadherin, N-terminal; extracellular Hs9256618 1618.0 S [S] Function unknown; A0A0A0MT89 Immunoglobulin kappa joining 1 OS=Homo sapiens OX=9606 GN=IGKJ1 PE=4 SV=2 - [KJ01_HUMAN] 1.105 0.993 1.009 0.944 1.093 0.798 1.112789527 0.568670943 0.863677951 0.421356131 1.01611279 0.900318654 0.73010064 0.649328247 P00915 Carbonic anhydrase 1 OS=Homo sapiens OX=9606 GN=CA1 PE=1 SV=2 - [CAH1_HUMAN] 0.827 1.084 1.241 0.928 0.985 0.688 0.762915129 0.004603962 0.94213198 0.247605991 1.144833948 0.084265678 0.698477157 0.791156416 GO:0015701;GO:0006730;GO:0006820;GO:0044281;GO:0044699;GO:0044710;GO:0051234;GO:0071702;GO:0009987;GO:0006811;GO:0006810;GO:0015711;GO:0044765;GO:0008150;GO:0008152;GO:0051179;GO:1902578;GO:0044237;GO:0044763; bicarbonate transport;one-carbon metabolic process;anion transport;small molecule metabolic process;single-organism process;single-organism metabolic process;establishment of localization;organic substance transport;cellular process;ion transport;transport;organic anion transport;single-organism transport;biological_process;metabolic process;localization;single-organism localization;cellular metabolic process;single-organism cellular process; 7;4;6;4;2;3;3;5;2;5;4;6;4;1;2;2;3;3;3; GO:0005829;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0005623;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421; cytosol;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;cell;extracellular vesicle;vesicle;extracellular organelle;cell part;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part; 5;3;2;4;4;2;3;4;3;2;3;1;4;2;3;2; GO:0003674;GO:0043169;GO:0046914;GO:0016829;GO:0008270;GO:0043167;GO:0046872;GO:0004064;GO:0016787;GO:0052689;GO:0003824;GO:0016788;GO:0004089;GO:0016835;GO:0016836;GO:0005488; molecular_function;cation binding;transition metal ion binding;lyase activity;zinc ion binding;ion binding;metal ion binding;arylesterase activity;hydrolase activity;carboxylic ester hydrolase activity;catalytic activity;hydrolase activity, acting on ester bonds;carbonate dehydratase activity;carbon-oxygen lyase activity;hydro-lyase activity;binding; 1;4;6;3;7;3;5;6;3;5;2;4;6;4;5;2; K01672 map00910; Nitrogen metabolism; IPR018442;IPR023561;IPR001148;IPR018338; Carbonic anhydrase, CA1;Carbonic anhydrase, alpha-class;Alpha carbonic anhydrase;Carbonic anhydrase, alpha-class, conserved site; cytosol Hs4502517 542.0 R [R] General function prediction only; A0A075B6S5 Immunoglobulin kappa variable 1-27 OS=Homo sapiens OX=9606 GN=IGKV1-27 PE=3 SV=1 - [KV127_HUMAN] 1.166 0.883 0.951 1.047 0.999 1.044 1.320498301 0.017797602 1.048048048 0.4338758 1.077010193 0.775054679 1.045045045 0.352543297 IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular A0A075B6S4 Immunoglobulin kappa variable 1D-17 OS=Homo sapiens OX=9606 GN=IGKV1D-17 PE=3 SV=1 - [KVD17_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P02743 Serum amyloid P-component OS=Homo sapiens OX=9606 GN=APCS PE=1 SV=2 - [SAMP_HUMAN] 0.933 0.923 1.154 0.982 0.984 1.323 1.010834236 0.618682653 0.99796748 0.229068867 1.250270856 1.68E-19 1.344512195 2.06E-09 GO:0080090;GO:0019222;GO:0030224;GO:0048585;GO:0048583;GO:0031348;GO:0016043;GO:0052203;GO:0002573;GO:0044866;GO:0071840;GO:0052204;GO:0065003;GO:0050728;GO:0010605;GO:0048869;GO:0002674;GO:0070271;GO:0009611;GO:0044419;GO:0019058;GO:0051817;GO:0044092;GO:0048519;GO:0002683;GO:1903016;GO:1903015;GO:0060255;GO:1903018;GO:1903019;GO:0044868;GO:0044869;GO:0002673;GO:0051702;GO:0051701;GO:0044867;GO:1903706;GO:1903707;GO:0051704;GO:0044359;GO:0009605;GO:0019538;GO:0045655;GO:0045656;GO:0002376;GO:0044788;GO:0046718;GO:0022607;GO:0006457;GO:0044871;GO:0044870;GO:0050789;GO:0002761;GO:0044267;GO:0002762;GO:0051346;GO:0044260;GO:0065007;GO:0052205;GO:0065009;GO:0065008;GO:0051131;GO:0052422;GO:0044362;GO:0050793;GO:0050792;GO:0050790;GO:0042060;GO:0050794;GO:0006952;GO:0043903;GO:0006950;GO:0043901;GO:0008150;GO:0008152;GO:0006955;GO:0002526;GO:0031347;GO:0052428;GO:0002521;GO:0002520;GO:0051336;GO:0006953;GO:0050896;GO:0043900;GO:0045638;GO:0045637;GO:0044085;GO:0032102;GO:0006954;GO:0032101;GO:0030154;GO:0050727;GO:0030260;GO:0052126;GO:0009892;GO:0043086;GO:0044699;GO:0051248;GO:0052055;GO:1903900;GO:1903901;GO:0051241;GO:0051246;GO:0051851;GO:0048513;GO:1903034;GO:1903035;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0044793;GO:0044707;GO:0051093;GO:1901135;GO:0043170;GO:0051239;GO:0051828;GO:0030099;GO:0030097;GO:0080134;GO:0043933;GO:0031324;GO:0031323;GO:0046596;GO:0046597;GO:0061041;GO:0061045;GO:0034622;GO:0009100;GO:0007275;GO:0002682;GO:0071822;GO:0071704;GO:0052405;GO:0048534;GO:0045087;GO:0006461;GO:0048731;GO:0044767;GO:0044764;GO:0044763;GO:0052403;GO:0043623;GO:0044003;GO:0040011;GO:0044238;GO:0040013;GO:0040012;GO:0052199;GO:0048856;GO:0052192;GO:0044237;GO:1902106;GO:1902105;GO:0044409;GO:2000026;GO:0016032;GO:0048525;GO:0044403;GO:0051806;GO:0035821;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;monocyte differentiation;negative regulation of response to stimulus;regulation of response to stimulus;negative regulation of defense response;cellular component organization;modulation of catalytic activity in other organism involved in symbiotic interaction;myeloid leukocyte differentiation;modulation by host of viral exo-alpha-sialidase activity;cellular component organization or biogenesis;negative regulation of molecular function in other organism involved in symbiotic interaction;macromolecular complex assembly;negative regulation of inflammatory response;negative regulation of macromolecule metabolic process;cellular developmental process;negative regulation of acute inflammatory response;protein complex biogenesis;response to wounding;interspecies interaction between organisms;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of molecular function;negative regulation of biological process;negative regulation of immune system process;negative regulation of exo-alpha-sialidase activity;regulation of exo-alpha-sialidase activity;regulation of macromolecule metabolic process;regulation of glycoprotein metabolic process;negative regulation of glycoprotein metabolic process;modulation by host of viral molecular function;negative regulation by host of viral exo-alpha-sialidase activity;regulation of acute inflammatory response;interaction with symbiont;interaction with host;modulation by host of viral catalytic activity;regulation of hemopoiesis;negative regulation of hemopoiesis;multi-organism process;modulation of molecular function in other organism;response to external stimulus;protein metabolic process;regulation of monocyte differentiation;negative regulation of monocyte differentiation;immune system process;modulation by host of viral process;viral entry into host cell;cellular component assembly;protein folding;negative regulation by host of viral glycoprotein metabolic process;modulation by host of viral glycoprotein metabolic process;regulation of biological process;regulation of myeloid leukocyte differentiation;cellular protein metabolic process;negative regulation of myeloid leukocyte differentiation;negative regulation of hydrolase activity;cellular macromolecule metabolic process;biological regulation;modulation of molecular function in other organism involved in symbiotic interaction;regulation of molecular function;regulation of biological quality;chaperone-mediated protein complex assembly;modulation by host of symbiont catalytic activity;negative regulation of molecular function in other organism;regulation of developmental process;regulation of viral process;regulation of catalytic activity;wound healing;regulation of cellular process;defense response;regulation of symbiosis, encompassing mutualism through parasitism;response to stress;negative regulation of multi-organism process;biological_process;metabolic process;immune response;acute inflammatory response;regulation of defense response;modification by host of symbiont molecular function;leukocyte differentiation;immune system development;regulation of hydrolase activity;acute-phase response;response to stimulus;regulation of multi-organism process;negative regulation of myeloid cell differentiation;regulation of myeloid cell differentiation;cellular component biogenesis;negative regulation of response to external stimulus;inflammatory response;regulation of response to external stimulus;cell differentiation;regulation of inflammatory response;entry into host cell;movement in host environment;negative regulation of metabolic process;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;modulation by symbiont of host molecular function;regulation of viral life cycle;negative regulation of viral life cycle;negative regulation of multicellular organismal process;regulation of protein metabolic process;modification by host of symbiont morphology or physiology;animal organ development;regulation of response to wounding;negative regulation of response to wounding;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation by host of viral process;single-multicellular organism process;negative regulation of developmental process;carbohydrate derivative metabolic process;macromolecule metabolic process;regulation of multicellular organismal process;entry into other organism involved in symbiotic interaction;myeloid cell differentiation;hemopoiesis;regulation of response to stress;macromolecular complex subunit organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of viral entry into host cell;negative regulation of viral entry into host cell;regulation of wound healing;negative regulation of wound healing;cellular macromolecular complex assembly;glycoprotein metabolic process;multicellular organism development;regulation of immune system process;protein complex subunit organization;organic substance metabolic process;negative regulation by host of symbiont molecular function;hematopoietic or lymphoid organ development;innate immune response;protein complex assembly;system development;single-organism developmental process;multi-organism cellular process;single-organism cellular process;negative regulation by host of symbiont catalytic activity;cellular protein complex assembly;modification by symbiont of host morphology or physiology;locomotion;primary metabolic process;negative regulation of locomotion;regulation of locomotion;negative regulation of catalytic activity in other organism involved in symbiotic interaction;anatomical structure development;movement in environment of other organism involved in symbiotic interaction;cellular metabolic process;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;entry into host;regulation of multicellular organismal development;viral process;negative regulation of viral process;symbiosis, encompassing mutualism through parasitism;entry into cell of other organism involved in symbiotic interaction;modification of morphology or physiology of other organism;negative regulation of cellular process; 4;3;8;3;3;4;3;5;7;7;2;6;5;5;4;4;6;4;4;3;5;4;4;2;3;7;6;4;5;5;7;8;6;4;4;7;4;4;2;4;3;4;7;7;2;6;6;4;3;6;6;2;6;5;6;6;4;2;5;3;3;7;6;5;3;4;4;5;3;4;4;3;3;1;2;3;6;5;6;6;3;5;7;2;3;5;5;3;4;5;4;5;5;6;4;3;5;2;5;6;5;5;3;5;5;4;5;4;2;2;2;4;4;5;3;3;4;4;3;4;6;5;4;4;4;4;4;4;6;5;6;5;4;3;5;3;7;4;4;5;4;3;3;3;7;6;5;2;3;3;3;6;3;3;3;5;5;5;4;4;4;4;5;3;3; GO:0031982;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0005622;GO:0043227;GO:0072562;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0070062;GO:0043226;GO:0005576;GO:1903561;GO:0005615;GO:0005575; vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;intracellular;membrane-bounded organelle;blood microparticle;nucleus;cell part;intracellular organelle;cell;extracellular exosome;organelle;extracellular region;extracellular vesicle;extracellular space;cellular_component; 4;3;4;3;2;3;3;3;5;2;3;2;4;2;2;3;3;1; GO:0046872;GO:0003674;GO:0005488;GO:0001849;GO:0001848;GO:0001846;GO:0046790;GO:0051082;GO:0043169;GO:0043167;GO:0005509;GO:0005515;GO:0030246; metal ion binding;molecular_function;binding;complement component C1q binding;complement binding;opsonin binding;virion binding;unfolded protein binding;cation binding;ion binding;calcium ion binding;protein binding;carbohydrate binding; 5;1;2;5;4;4;3;4;4;3;6;3;3; K23267 IPR001759;IPR013320;IPR030476; Pentraxin-related;Concanavalin A-like lectin/glucanase domain;Pentaxin, conserved site; extracellular 32471540 53.1 U [U] Intracellular trafficking, secretion, and vesicular transport; COG2911 Autotransporter translocation and assembly factor TamB Q96MI6 Protein phosphatase 1M OS=Homo sapiens OX=9606 GN=PPM1M PE=2 SV=1 - [PPM1M_HUMAN] nan nan nan nan nan nan nan 4.49E-05 nan 8.14E-06 nan 0.012290006 nan 0.497197469 GO:0016311;GO:0006470;GO:0044237;GO:0044267;GO:0044260;GO:0071704;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0043170;GO:0006796;GO:0006793; dephosphorylation;protein dephosphorylation;cellular metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;macromolecule metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process; 6;7;3;5;4;3;2;6;5;5;1;2;3;4;4;5;4; GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005575;GO:0044424; intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;cellular_component;intracellular part; 3;3;3;2;5;4;2;2;1;3; GO:0016791;GO:0004721;GO:0042578;GO:0003674;GO:0008420;GO:0043167;GO:0046872;GO:0016787;GO:0043169;GO:0030145;GO:0046914;GO:0003824;GO:0016788;GO:0004722;GO:0005488; phosphatase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;molecular_function;CTD phosphatase activity;ion binding;metal ion binding;hydrolase activity;cation binding;manganese ion binding;transition metal ion binding;catalytic activity;hydrolase activity, acting on ester bonds;protein serine/threonine phosphatase activity;binding; 6;7;5;1;9;3;5;3;4;7;6;2;4;8;2; K17507 IPR001932;IPR015655; PPM-type phosphatase domain;Protein phosphatase 2C family; cytosol, nucleus Hs21389471 555.0 T [T] Signal transduction mechanisms; P02747 Complement C1q subcomponent subunit C OS=Homo sapiens OX=9606 GN=C1QC PE=1 SV=3 - [C1QC_HUMAN] 1.016 1.112 0.942 0.886 1.094 1.363 0.913669065 0.150100737 0.809872029 0.013678189 0.847122302 0.409960956 1.245886654 0.006349175 GO:0030225;GO:0048584;GO:0048583;GO:0002455;GO:0002573;GO:0044710;GO:0048869;GO:0030852;GO:0030853;GO:0030851;GO:0048518;GO:0065007;GO:0019724;GO:1903706;GO:1903707;GO:0044707;GO:0019538;GO:0002376;GO:0045650;GO:0002761;GO:0002762;GO:0045649;GO:0002684;GO:0002682;GO:0002683;GO:0050793;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0006956;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0002521;GO:0002520;GO:0050896;GO:0045638;GO:0008150;GO:0045637;GO:0051239;GO:0030154;GO:0044699;GO:0002443;GO:0051241;GO:0048513;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0048519;GO:0051093;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0030099;GO:0048731;GO:0007275;GO:0072376;GO:0050789;GO:0071704;GO:0048534;GO:0045087;GO:0044767;GO:0002449;GO:0044763;GO:0044238;GO:0048856;GO:0030097;GO:1902106;GO:1902105;GO:2000026;GO:0002250;GO:0002253;GO:0002252;GO:0048523; macrophage differentiation;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;myeloid leukocyte differentiation;single-organism metabolic process;cellular developmental process;regulation of granulocyte differentiation;negative regulation of granulocyte differentiation;granulocyte differentiation;positive regulation of biological process;biological regulation;B cell mediated immunity;regulation of hemopoiesis;negative regulation of hemopoiesis;single-multicellular organism process;protein metabolic process;immune system process;negative regulation of macrophage differentiation;regulation of myeloid leukocyte differentiation;negative regulation of myeloid leukocyte differentiation;regulation of macrophage differentiation;positive regulation of immune system process;regulation of immune system process;negative regulation of immune system process;regulation of developmental process;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;complement activation;metabolic process;immune response;complement activation, classical pathway;humoral immune response;leukocyte differentiation;immune system development;response to stimulus;negative regulation of myeloid cell differentiation;biological_process;regulation of myeloid cell differentiation;regulation of multicellular organismal process;cell differentiation;single-organism process;leukocyte mediated immunity;negative regulation of multicellular organismal process;animal organ development;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of biological process;negative regulation of developmental process;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;myeloid cell differentiation;system development;multicellular organism development;protein activation cascade;regulation of biological process;organic substance metabolic process;hematopoietic or lymphoid organ development;innate immune response;single-organism developmental process;lymphocyte mediated immunity;single-organism cellular process;primary metabolic process;anatomical structure development;hemopoiesis;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;adaptive immune response;activation of immune response;immune effector process;negative regulation of cellular process; 8;3;3;5;7;3;4;7;7;8;2;2;6;4;4;3;4;2;7;6;6;7;3;3;3;3;3;4;3;7;4;2;3;5;4;6;3;2;5;1;5;3;5;2;4;3;4;2;2;2;4;4;2;3;4;5;4;4;6;4;4;3;2;3;4;4;3;5;3;3;3;5;5;5;4;4;3;3;3; GO:0031982;GO:0043234;GO:0043230;GO:0044421;GO:0043227;GO:0043226;GO:0072562;GO:0005581;GO:0005615;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576; vesicle;protein complex;extracellular organelle;extracellular region part;membrane-bounded organelle;organelle;blood microparticle;collagen trimer;extracellular space;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region; 4;3;3;2;3;2;3;4;3;3;4;2;1;2; K03988 map04610;map05020;map05133;map05142;map05150;map05322; Complement and coagulation cascades;Prion diseases;Pertussis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Systemic lupus erythematosus; IPR008983;IPR008160;IPR001073; Tumour necrosis factor-like domain;Collagen triple helix repeat;C1q domain; extracellular 186682089 63.5 MU [M] Cell wall/membrane/envelope biogenesis; [U] Intracellular trafficking, secretion, and vesicular transport; COG3468 Type V secretory pathway, adhesin AidA Q9Y305 Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2 - [ACOT9_HUMAN] 0.553 0.435 2.651 0.567 0.355 1.52 1.271264368 0.089794969 1.597183099 0.157970879 6.094252874 4.66E-05 4.281690141 0.000525113 GO:0006637;GO:0006732;GO:0006639;GO:0006638;GO:0046949;GO:0044249;GO:0035336;GO:0035337;GO:0044255;GO:0044699;GO:0035384;GO:1901576;GO:0051186;GO:0006641;GO:0051188;GO:0071704;GO:0046463;GO:0046460;GO:0035383;GO:0006629;GO:0045017;GO:0009987;GO:0044710;GO:0009058;GO:0044711;GO:0008150;GO:0008152;GO:0046486;GO:0008610;GO:0044238;GO:0044272;GO:0044237;GO:0019432;GO:0006790;GO:0071616;GO:0035338;GO:0006793;GO:0044763;GO:0009108;GO:0044281; acyl-CoA metabolic process;coenzyme metabolic process;acylglycerol metabolic process;neutral lipid metabolic process;fatty-acyl-CoA biosynthetic process;cellular biosynthetic process;long-chain fatty-acyl-CoA metabolic process;fatty-acyl-CoA metabolic process;cellular lipid metabolic process;single-organism process;thioester biosynthetic process;organic substance biosynthetic process;cofactor metabolic process;triglyceride metabolic process;cofactor biosynthetic process;organic substance metabolic process;acylglycerol biosynthetic process;neutral lipid biosynthetic process;thioester metabolic process;lipid metabolic process;glycerolipid biosynthetic process;cellular process;single-organism metabolic process;biosynthetic process;single-organism biosynthetic process;biological_process;metabolic process;glycerolipid metabolic process;lipid biosynthetic process;primary metabolic process;sulfur compound biosynthetic process;cellular metabolic process;triglyceride biosynthetic process;sulfur compound metabolic process;acyl-CoA biosynthetic process;long-chain fatty-acyl-CoA biosynthetic process;phosphorus metabolic process;single-organism cellular process;coenzyme biosynthetic process;small molecule metabolic process; 5;5;6;5;7;4;7;6;4;2;5;4;4;7;5;3;6;5;4;4;5;2;3;3;4;1;2;5;5;3;5;3;7;4;6;8;4;3;6;4; GO:0031974;GO:0043229;GO:0005623;GO:0005759;GO:0043227;GO:0005737;GO:0005739;GO:0043226;GO:0044446;GO:0044429;GO:0043231;GO:0043233;GO:0044464;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;cell;mitochondrial matrix;membrane-bounded organelle;cytoplasm;mitochondrion;organelle;intracellular organelle part;mitochondrial part;intracellular membrane-bounded organelle;organelle lumen;cell part;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;intracellular part;organelle part; 2;3;2;5;3;4;5;2;3;4;4;3;2;3;1;4;4;3;2; GO:0016790;GO:0003674;GO:0016289;GO:0003986;GO:0016787;GO:0052689;GO:0003824;GO:0016788; thiolester hydrolase activity;molecular_function;CoA hydrolase activity;acetyl-CoA hydrolase activity;hydrolase activity;carboxylic ester hydrolase activity;catalytic activity;hydrolase activity, acting on ester bonds; 5;1;6;7;3;5;2;4; K17361 IPR029069;IPR033120; HotDog domain;Hotdog acyl-CoA thioesterase (ACOT)-type domain; mitochondria Hs6912518 831.0 I [I] Lipid transport and metabolism; P02745 Complement C1q subcomponent subunit A OS=Homo sapiens OX=9606 GN=C1QA PE=1 SV=2 - [C1QA_HUMAN] 1.146 1.124 0.792 1.13 1.098 1.018 1.019572954 0.781003467 1.029143898 0.884306354 0.704626335 0.000504269 0.927140255 0.629312906 GO:0010035;GO:0010038;GO:0010039;GO:0048584;GO:0048583;GO:0023052;GO:0007154;GO:0002455;GO:0050789;GO:0044699;GO:0044710;GO:0006959;GO:0072376;GO:0002443;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:1990267;GO:0019724;GO:0044700;GO:0045087;GO:0009987;GO:0006952;GO:0002449;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0007267;GO:0042221;GO:0006958;GO:0044238;GO:0050776;GO:0002460;GO:0019538;GO:0050896;GO:0044763;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0006956; response to inorganic substance;response to metal ion;response to iron ion;positive regulation of response to stimulus;regulation of response to stimulus;signaling;cell communication;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;single-organism metabolic process;humoral immune response;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;response to transition metal nanoparticle;B cell mediated immunity;single organism signaling;innate immune response;cellular process;defense response;lymphocyte mediated immunity;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;cell-cell signaling;response to chemical;complement activation, classical pathway;primary metabolic process;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;single-organism cellular process;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;complement activation; 4;5;5;3;3;2;4;5;2;2;3;4;3;4;3;3;3;2;2;4;6;3;4;2;4;5;3;7;1;2;3;4;3;5;3;4;5;4;2;3;4;4;2;4;3;3;4; GO:0032991;GO:0043227;GO:0005575;GO:0070062;GO:0005615;GO:0043226;GO:1903561;GO:0031982;GO:0043234;GO:0043230;GO:0005602;GO:0005581;GO:0005576;GO:0044421; macromolecular complex;membrane-bounded organelle;cellular_component;extracellular exosome;extracellular space;organelle;extracellular vesicle;vesicle;protein complex;extracellular organelle;complement component C1 complex;collagen trimer;extracellular region;extracellular region part; 2;3;1;4;3;2;3;4;3;3;3;4;2;2; K03986 map04610;map05020;map05133;map05142;map05150;map05322; Complement and coagulation cascades;Prion diseases;Pertussis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Systemic lupus erythematosus; IPR008983;IPR008160;IPR001073; Tumour necrosis factor-like domain;Collagen triple helix repeat;C1q domain; extracellular 186682089 57.0 MU [M] Cell wall/membrane/envelope biogenesis; [U] Intracellular trafficking, secretion, and vesicular transport; COG3468 Type V secretory pathway, adhesin AidA P01031 Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4 - [CO5_HUMAN] 1.045 0.985 1.074 0.982 0.974 1.031 1.060913706 0.113572837 1.008213552 0.405107436 1.09035533 3.21E-05 1.058521561 0.004338433 GO:0032880;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0051047;GO:0001701;GO:0050922;GO:0048584;GO:0048583;GO:0032147;GO:0045765;GO:0098779;GO:0001816;GO:0072358;GO:0050920;GO:0007165;GO:0007166;GO:0060326;GO:0002455;GO:0023014;GO:0007005;GO:0044712;GO:0051716;GO:0010604;GO:0042330;GO:0009966;GO:0009967;GO:0071840;GO:0000165;GO:0009611;GO:0048514;GO:0044093;GO:0051049;GO:0048518;GO:0002682;GO:0002526;GO:0033036;GO:0032722;GO:0048585;GO:0002683;GO:0019724;GO:0030595;GO:0006935;GO:0051050;GO:0060255;GO:0045859;GO:2000257;GO:0045184;GO:0009306;GO:0050776;GO:0030162;GO:0051222;GO:0002673;GO:0090197;GO:0042325;GO:0044700;GO:0042327;GO:0044707;GO:0009605;GO:0048870;GO:0019538;GO:0007186;GO:0051094;GO:0072359;GO:0002376;GO:0002688;GO:0033554;GO:0030449;GO:0009893;GO:0050708;GO:0033674;GO:1903532;GO:1903008;GO:0006928;GO:0048246;GO:1901342;GO:0002920;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0019835;GO:0044267;GO:0009653;GO:0051347;GO:0044260;GO:0001568;GO:0043549;GO:0016043;GO:0002686;GO:0090195;GO:0002684;GO:0002685;GO:0065007;GO:0043085;GO:0045087;GO:0065009;GO:0016477;GO:0022603;GO:0048646;GO:0002689;GO:0070201;GO:0051046;GO:0050793;GO:0016236;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0006957;GO:0008152;GO:0006955;GO:1902533;GO:0031347;GO:1902531;GO:0006952;GO:0046903;GO:0070613;GO:0051604;GO:0050714;GO:1904018;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0002697;GO:0090196;GO:0044767;GO:2000146;GO:0006956;GO:1903317;GO:0001819;GO:0051240;GO:0032102;GO:0006954;GO:0032101;GO:0016310;GO:0050727;GO:0023056;GO:0043406;GO:0043405;GO:0009792;GO:0023052;GO:1903530;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0006958;GO:0044699;GO:0043408;GO:0006959;GO:0010562;GO:0051246;GO:0051247;GO:0032642;GO:0032270;GO:0006810;GO:0031399;GO:0006508;GO:0043009;GO:1903034;GO:0032502;GO:0006996;GO:0032501;GO:0009987;GO:0051271;GO:0051270;GO:0040011;GO:0048519;GO:0016485;GO:0032879;GO:0002443;GO:0010760;GO:0042221;GO:0032268;GO:0050715;GO:0000422;GO:0000423;GO:0010575;GO:0010574;GO:0010573;GO:0050778;GO:0043170;GO:0051239;GO:0001817;GO:0051674;GO:0016064;GO:0048731;GO:0045860;GO:0009790;GO:0080134;GO:0010758;GO:0000187;GO:0050707;GO:0060341;GO:0001944;GO:0031325;GO:0032602;GO:0031323;GO:0050900;GO:0051234;GO:0001525;GO:0007275;GO:0050663;GO:0051223;GO:0072376;GO:0032940;GO:1902589;GO:0045766;GO:0098780;GO:0071704;GO:0010467;GO:0071702;GO:2000145;GO:0010468;GO:0030336;GO:0006468;GO:0030334;GO:0045937;GO:0061726;GO:0097529;GO:0002252;GO:0006464;GO:0051174;GO:0002449;GO:0044765;GO:0044763;GO:0002460;GO:0007154;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0006914;GO:0044238;GO:0040013;GO:0040012;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:0002250;GO:0002253;GO:0006793;GO:0015031;GO:1904951;GO:0001932;GO:0022411;GO:0001934;GO:0048523;GO:0048522; regulation of protein localization;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of secretion;in utero embryonic development;negative regulation of chemotaxis;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;regulation of angiogenesis;mitophagy in response to mitochondrial depolarization;cytokine production;cardiovascular system development;regulation of chemotaxis;signal transduction;cell surface receptor signaling pathway;cell chemotaxis;humoral immune response mediated by circulating immunoglobulin;signal transduction by protein phosphorylation;mitochondrion organization;single-organism catabolic process;cellular response to stimulus;positive regulation of macromolecule metabolic process;taxis;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;response to wounding;blood vessel morphogenesis;positive regulation of molecular function;regulation of transport;positive regulation of biological process;regulation of immune system process;acute inflammatory response;macromolecule localization;positive regulation of chemokine production;negative regulation of response to stimulus;negative regulation of immune system process;B cell mediated immunity;leukocyte chemotaxis;chemotaxis;positive regulation of transport;regulation of macromolecule metabolic process;regulation of protein kinase activity;regulation of protein activation cascade;establishment of protein localization;protein secretion;regulation of immune response;regulation of proteolysis;positive regulation of protein transport;regulation of acute inflammatory response;positive regulation of chemokine secretion;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;single-multicellular organism process;response to external stimulus;cell motility;protein metabolic process;G-protein coupled receptor signaling pathway;positive regulation of developmental process;circulatory system development;immune system process;regulation of leukocyte chemotaxis;cellular response to stress;regulation of complement activation;positive regulation of metabolic process;regulation of protein secretion;positive regulation of kinase activity;positive regulation of secretion by cell;organelle disassembly;movement of cell or subcellular component;macrophage chemotaxis;regulation of vasculature development;regulation of humoral immune response;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cytolysis;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cellular macromolecule metabolic process;blood vessel development;regulation of kinase activity;cellular component organization;negative regulation of leukocyte migration;chemokine secretion;positive regulation of immune system process;regulation of leukocyte migration;biological regulation;positive regulation of catalytic activity;innate immune response;regulation of molecular function;cell migration;regulation of anatomical structure morphogenesis;anatomical structure formation involved in morphogenesis;negative regulation of leukocyte chemotaxis;regulation of establishment of protein localization;regulation of secretion;regulation of developmental process;macroautophagy;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;complement activation, alternative pathway;metabolic process;immune response;positive regulation of intracellular signal transduction;regulation of defense response;regulation of intracellular signal transduction;defense response;secretion;regulation of protein processing;protein maturation;positive regulation of protein secretion;positive regulation of vasculature development;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;regulation of immune effector process;regulation of chemokine secretion;single-organism developmental process;negative regulation of cell motility;complement activation;regulation of protein maturation;positive regulation of cytokine production;positive regulation of multicellular organismal process;negative regulation of response to external stimulus;inflammatory response;regulation of response to external stimulus;phosphorylation;regulation of inflammatory response;positive regulation of signaling;positive regulation of MAP kinase activity;regulation of MAP kinase activity;embryo development ending in birth or egg hatching;signaling;regulation of secretion by cell;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;complement activation, classical pathway;single-organism process;regulation of MAPK cascade;humoral immune response;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of chemokine production;positive regulation of cellular protein metabolic process;transport;regulation of protein modification process;proteolysis;chordate embryonic development;regulation of response to wounding;developmental process;organelle organization;multicellular organismal process;cellular process;negative regulation of cellular component movement;regulation of cellular component movement;locomotion;negative regulation of biological process;protein processing;regulation of localization;leukocyte mediated immunity;negative regulation of macrophage chemotaxis;response to chemical;regulation of cellular protein metabolic process;positive regulation of cytokine secretion;mitophagy;macromitophagy;positive regulation of vascular endothelial growth factor production;regulation of vascular endothelial growth factor production;vascular endothelial growth factor production;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;regulation of cytokine production;localization of cell;immunoglobulin mediated immune response;system development;positive regulation of protein kinase activity;embryo development;regulation of response to stress;regulation of macrophage chemotaxis;activation of MAPK activity;regulation of cytokine secretion;regulation of cellular localization;vasculature development;positive regulation of cellular metabolic process;chemokine production;regulation of cellular metabolic process;leukocyte migration;establishment of localization;angiogenesis;multicellular organism development;cytokine secretion;regulation of protein transport;protein activation cascade;secretion by cell;single-organism organelle organization;positive regulation of angiogenesis;response to mitochondrial depolarisation;organic substance metabolic process;gene expression;organic substance transport;regulation of cell motility;regulation of gene expression;negative regulation of cell migration;protein phosphorylation;regulation of cell migration;positive regulation of phosphate metabolic process;mitochondrion disassembly;myeloid leukocyte migration;immune effector process;cellular protein modification process;regulation of phosphorus metabolic process;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;cell communication;catabolic process;localization;single-organism localization;cellular localization;autophagy;primary metabolic process;negative regulation of locomotion;regulation of locomotion;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;adaptive immune response;activation of immune response;phosphorus metabolic process;protein transport;positive regulation of establishment of protein localization;regulation of protein phosphorylation;cellular component disassembly;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 4;4;6;4;3;4;8;4;3;3;9;5;6;4;5;4;4;5;5;5;4;5;4;3;4;3;4;4;2;5;4;4;4;4;2;3;6;3;5;3;3;6;4;4;3;4;7;4;4;5;4;6;4;6;6;7;3;7;3;3;3;4;5;3;5;2;5;4;5;3;6;7;4;5;4;5;5;5;9;5;8;2;3;5;3;6;4;4;6;3;4;6;3;4;2;5;4;3;4;4;3;5;5;5;3;4;4;3;3;6;5;5;1;5;2;3;5;5;5;4;5;7;5;5;4;2;6;3;5;4;6;3;4;4;6;4;3;4;5;4;6;5;3;7;7;6;2;5;4;3;4;4;5;2;6;4;5;5;5;5;5;4;6;5;7;5;2;4;2;2;4;4;2;2;6;3;4;6;3;5;5;4;5;5;5;5;4;4;3;4;3;7;4;8;5;4;6;8;5;4;5;4;5;4;3;3;4;4;5;5;3;4;4;5;5;3;5;5;4;5;5;7;5;6;6;4;3;6;5;5;4;3;5;4;3;2;3;3;3;3;3;3;3;3;5;4;4;3;4;5;3;7;4;7;3;3; GO:0016020;GO:0043230;GO:0044425;GO:0044421;GO:0044464;GO:0043227;GO:0031982;GO:0043234;GO:0031224;GO:0031226;GO:0046930;GO:0005615;GO:0044459;GO:0005623;GO:0016021;GO:0071944;GO:0098797;GO:0070062;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0005579;GO:0005575;GO:0098796;GO:0005576; membrane;extracellular organelle;membrane part;extracellular region part;cell part;membrane-bounded organelle;vesicle;protein complex;intrinsic component of membrane;intrinsic component of plasma membrane;pore complex;extracellular space;plasma membrane part;cell;integral component of membrane;cell periphery;plasma membrane protein complex;extracellular exosome;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;membrane attack complex;cellular_component;membrane protein complex;extracellular region; 2;3;2;2;2;3;4;3;3;4;4;3;3;2;4;3;4;4;2;4;3;3;2;5;1;3;2; GO:0030414;GO:0098772;GO:0004857;GO:0005126;GO:0005125;GO:0003674;GO:0005488;GO:0061135;GO:0061134;GO:0001664;GO:0008009;GO:0042379;GO:0004866;GO:0005515;GO:0005102;GO:0030234; peptidase inhibitor activity;molecular function regulator;enzyme inhibitor activity;cytokine receptor binding;cytokine activity;molecular_function;binding;endopeptidase regulator activity;peptidase regulator activity;G-protein coupled receptor binding;chemokine activity;chemokine receptor binding;endopeptidase inhibitor activity;protein binding;receptor binding;enzyme regulator activity; 5;2;4;5;5;1;2;5;4;5;6;6;6;3;4;3; K03994 map04610;map05020;map05133;map05150;map05168;map05322; Complement and coagulation cascades;Prion diseases;Pertussis;Staphylococcus aureus infection;Herpes simplex infection;Systemic lupus erythematosus; IPR008930;IPR018081;IPR009048;IPR000020;IPR008993;IPR018933;IPR001134;IPR013783;IPR001599;IPR011625;IPR011626;IPR002890;IPR001840; Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;Anaphylatoxin, complement system;Alpha-macroglobulin, receptor-binding;Anaphylatoxin/fibulin;Tissue inhibitor of metalloproteinases-like, OB-fold;Netrin module, non-TIMP type;Netrin domain;Immunoglobulin-like fold;Alpha-2-macroglobulin;Alpha-2-macroglobulin, N-terminal 2;Alpha-macroglobulin complement component;Alpha-2-macroglobulin, N-terminal;Anaphylatoxin, complement system domain; endoplasmic reticulum Hs4502507 3477.0 O [O] Posttranslational modification, protein turnover, chaperones; P02749 Beta-2-glycoprotein 1 OS=Homo sapiens OX=9606 GN=APOH PE=1 SV=3 - [APOH_HUMAN] 1.043 0.982 1.083 0.902 1.012 0.823 1.062118126 0.00849448 0.891304348 1.82E-09 1.102851324 1.26E-08 0.813241107 0.144311086 GO:0007599;GO:0019222;GO:0007597;GO:0007596;GO:0048583;GO:0050680;GO:0045765;GO:0072359;GO:0072358;GO:0034197;GO:0034196;GO:0080090;GO:0044712;GO:0044710;GO:0009611;GO:0090132;GO:0048513;GO:0045834;GO:0044093;GO:0010898;GO:0048519;GO:0033036;GO:0048585;GO:0046503;GO:0033032;GO:0042127;GO:0048584;GO:0031100;GO:0060548;GO:0001667;GO:0050678;GO:0046486;GO:0010876;GO:0010033;GO:0010467;GO:0044248;GO:0016477;GO:0009605;GO:0044707;GO:0048870;GO:0019538;GO:0010633;GO:0019433;GO:0030195;GO:0030194;GO:0009896;GO:0009894;GO:0060263;GO:0009892;GO:0009893;GO:0022603;GO:0060268;GO:0006928;GO:0050820;GO:1901342;GO:0051674;GO:0042981;GO:0050789;GO:0043542;GO:1901575;GO:0051345;GO:0001568;GO:0016042;GO:1900046;GO:1900047;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:1900048;GO:0048646;GO:0006810;GO:0006629;GO:0050793;GO:0001944;GO:0050790;GO:0042060;GO:0050794;GO:0012501;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0050996;GO:0010656;GO:0010657;GO:0051234;GO:0050818;GO:0050819;GO:0034014;GO:0048514;GO:0051336;GO:0042730;GO:0051604;GO:0051241;GO:0050896;GO:0045730;GO:2000145;GO:2000146;GO:0061365;GO:0060193;GO:0060191;GO:0032102;GO:0051239;GO:0051918;GO:0006869;GO:0030193;GO:0006639;GO:0006638;GO:0051004;GO:0051006;GO:0044242;GO:0009653;GO:0010632;GO:0044699;GO:0010631;GO:0033033;GO:0034391;GO:0034390;GO:0051240;GO:0034392;GO:0031099;GO:0051917;GO:0050673;GO:0006508;GO:0046464;GO:1903034;GO:1903035;GO:0046461;GO:0032502;GO:0040011;GO:0032501;GO:0090208;GO:0010896;GO:0050878;GO:0006641;GO:0031331;GO:0009987;GO:0048518;GO:0051270;GO:0016485;GO:0044255;GO:0032879;GO:0090130;GO:0051093;GO:0007568;GO:0043170;GO:1901343;GO:0032103;GO:1903036;GO:0048731;GO:0080134;GO:0016525;GO:2000181;GO:0031329;GO:0008285;GO:0031325;GO:0090303;GO:0031323;GO:0040013;GO:0061041;GO:0061045;GO:0010660;GO:0008219;GO:0010941;GO:0007275;GO:0001525;GO:0072376;GO:0072378;GO:0008283;GO:0031639;GO:0031638;GO:0032101;GO:0071704;GO:0043067;GO:0043066;GO:0040012;GO:0071702;GO:0043069;GO:0030336;GO:0030334;GO:0019216;GO:0006915;GO:0044767;GO:0044765;GO:0044763;GO:0042221;GO:0090207;GO:0009056;GO:0051179;GO:1902578;GO:1901700;GO:0044238;GO:0051271;GO:0010594;GO:0010596;GO:0048856;GO:0050994;GO:0044237;GO:2000026;GO:0001937;GO:0033028;GO:0033993;GO:0001936;GO:0001935;GO:0048523;GO:0048522; hemostasis;regulation of metabolic process;blood coagulation, intrinsic pathway;blood coagulation;regulation of response to stimulus;negative regulation of epithelial cell proliferation;regulation of angiogenesis;circulatory system development;cardiovascular system development;triglyceride transport;acylglycerol transport;regulation of primary metabolic process;single-organism catabolic process;single-organism metabolic process;response to wounding;epithelium migration;animal organ development;positive regulation of lipid metabolic process;positive regulation of molecular function;positive regulation of triglyceride catabolic process;negative regulation of biological process;macromolecule localization;negative regulation of response to stimulus;glycerolipid catabolic process;regulation of myeloid cell apoptotic process;regulation of cell proliferation;positive regulation of response to stimulus;organ regeneration;negative regulation of cell death;ameboidal-type cell migration;regulation of epithelial cell proliferation;glycerolipid metabolic process;lipid localization;response to organic substance;gene expression;cellular catabolic process;cell migration;response to external stimulus;single-multicellular organism process;cell motility;protein metabolic process;negative regulation of epithelial cell migration;triglyceride catabolic process;negative regulation of blood coagulation;positive regulation of blood coagulation;positive regulation of catabolic process;regulation of catabolic process;regulation of respiratory burst;negative regulation of metabolic process;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;negative regulation of respiratory burst;movement of cell or subcellular component;positive regulation of coagulation;regulation of vasculature development;localization of cell;regulation of apoptotic process;regulation of biological process;endothelial cell migration;organic substance catabolic process;positive regulation of hydrolase activity;blood vessel development;lipid catabolic process;regulation of hemostasis;negative regulation of hemostasis;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;positive regulation of hemostasis;anatomical structure formation involved in morphogenesis;transport;lipid metabolic process;regulation of developmental process;vasculature development;regulation of catalytic activity;wound healing;regulation of cellular process;programmed cell death;response to stress;coagulation;biological_process;metabolic process;positive regulation of lipid catabolic process;negative regulation of muscle cell apoptotic process;muscle cell apoptotic process;establishment of localization;regulation of coagulation;negative regulation of coagulation;response to triglyceride;blood vessel morphogenesis;regulation of hydrolase activity;fibrinolysis;protein maturation;negative regulation of multicellular organismal process;response to stimulus;respiratory burst;regulation of cell motility;negative regulation of cell motility;positive regulation of triglyceride lipase activity;positive regulation of lipase activity;regulation of lipase activity;negative regulation of response to external stimulus;regulation of multicellular organismal process;negative regulation of fibrinolysis;lipid transport;regulation of blood coagulation;acylglycerol metabolic process;neutral lipid metabolic process;regulation of lipoprotein lipase activity;positive regulation of lipoprotein lipase activity;cellular lipid catabolic process;anatomical structure morphogenesis;regulation of epithelial cell migration;single-organism process;epithelial cell migration;negative regulation of myeloid cell apoptotic process;regulation of smooth muscle cell apoptotic process;smooth muscle cell apoptotic process;positive regulation of multicellular organismal process;negative regulation of smooth muscle cell apoptotic process;regeneration;regulation of fibrinolysis;epithelial cell proliferation;proteolysis;acylglycerol catabolic process;regulation of response to wounding;negative regulation of response to wounding;neutral lipid catabolic process;developmental process;locomotion;multicellular organismal process;positive regulation of triglyceride metabolic process;regulation of triglyceride catabolic process;regulation of body fluid levels;triglyceride metabolic process;positive regulation of cellular catabolic process;cellular process;positive regulation of biological process;regulation of cellular component movement;protein processing;cellular lipid metabolic process;regulation of localization;tissue migration;negative regulation of developmental process;aging;macromolecule metabolic process;negative regulation of vasculature development;positive regulation of response to external stimulus;positive regulation of response to wounding;system development;regulation of response to stress;negative regulation of angiogenesis;negative regulation of blood vessel morphogenesis;regulation of cellular catabolic process;negative regulation of cell proliferation;positive regulation of cellular metabolic process;positive regulation of wound healing;regulation of cellular metabolic process;negative regulation of locomotion;regulation of wound healing;negative regulation of wound healing;regulation of muscle cell apoptotic process;cell death;regulation of cell death;multicellular organism development;angiogenesis;protein activation cascade;blood coagulation, fibrin clot formation;cell proliferation;plasminogen activation;zymogen activation;regulation of response to external stimulus;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;regulation of locomotion;organic substance transport;negative regulation of programmed cell death;negative regulation of cell migration;regulation of cell migration;regulation of lipid metabolic process;apoptotic process;single-organism developmental process;single-organism transport;single-organism cellular process;response to chemical;regulation of triglyceride metabolic process;catabolic process;localization;single-organism localization;response to oxygen-containing compound;primary metabolic process;negative regulation of cellular component movement;regulation of endothelial cell migration;negative regulation of endothelial cell migration;anatomical structure development;regulation of lipid catabolic process;cellular metabolic process;regulation of multicellular organismal development;negative regulation of endothelial cell proliferation;myeloid cell apoptotic process;response to lipid;regulation of endothelial cell proliferation;endothelial cell proliferation;negative regulation of cellular process;positive regulation of cellular process; 5;3;4;5;3;5;5;5;5;7;6;4;4;3;4;5;4;4;4;6;2;3;3;6;7;4;3;5;4;5;5;5;4;4;5;4;4;3;3;3;4;4;8;5;5;4;4;4;3;3;4;4;4;4;5;3;6;2;7;4;6;4;5;4;4;2;5;3;3;4;3;4;4;3;5;4;5;3;5;3;4;1;2;5;7;7;3;4;4;5;4;5;6;5;3;2;4;4;4;8;7;6;4;3;3;5;5;6;5;7;8;5;3;4;2;6;7;8;8;3;8;4;6;4;5;7;5;4;6;2;2;2;5;6;4;7;5;2;2;4;6;4;3;4;3;4;4;4;4;4;4;4;5;5;5;4;4;5;4;3;6;5;7;4;4;4;4;3;4;3;8;7;4;3;5;6;3;5;5;5;5;5;6;3;4;3;3;5;3;2;3;4;3;4;5;5;3;5;3;4;6;7;5;6;5;3;3; GO:0034358;GO:0031982;GO:0034361;GO:0034364;GO:0043230;GO:0044424;GO:0044421;GO:0005622;GO:0042627;GO:0005737;GO:0034385;GO:0043227;GO:1990777;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0016020;GO:0005615;GO:0043226;GO:0005886;GO:1903561;GO:0070062;GO:0032994;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;vesicle;very-low-density lipoprotein particle;high-density lipoprotein particle;extracellular organelle;intracellular part;extracellular region part;intracellular;chylomicron;cytoplasm;triglyceride-rich lipoprotein particle;membrane-bounded organelle;lipoprotein particle;cell surface;cell part;cell;cell periphery;membrane;extracellular space;organelle;plasma membrane;extracellular vesicle;extracellular exosome;protein-lipid complex;macromolecular complex;cellular_component;extracellular region; 3;4;5;4;3;3;2;3;4;4;4;3;4;3;2;2;3;2;3;2;3;3;4;3;2;1;2; GO:0098772;GO:0060229;GO:0005543;GO:0097367;GO:0003674;GO:0005488;GO:0005539;GO:0001948;GO:0043167;GO:0042802;GO:0008289;GO:0008201;GO:0005515;GO:1901681;GO:0008047;GO:0060230;GO:0030234;GO:0043168; molecular function regulator;lipase activator activity;phospholipid binding;carbohydrate derivative binding;molecular_function;binding;glycosaminoglycan binding;glycoprotein binding;ion binding;identical protein binding;lipid binding;heparin binding;protein binding;sulfur compound binding;enzyme activator activity;lipoprotein lipase activator activity;enzyme regulator activity;anion binding; 2;5;4;3;1;2;4;4;3;4;3;4;3;3;4;6;3;4; K17305 IPR000436;IPR015104; Sushi/SCR/CCP domain;Beta-2-glycoprotein-1 fifth domain; extracellular Hs4557327 710.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; P02748 Complement component C9 OS=Homo sapiens OX=9606 GN=C9 PE=1 SV=2 - [CO9_HUMAN] 1.073 0.831 1.189 1.068 0.809 1.11 1.291215403 5.16E-20 1.320148331 2.66E-29 1.430806258 8.85E-27 1.372064277 1.12E-12 GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0002455;GO:0031347;GO:0051715;GO:0044710;GO:0050727;GO:0044419;GO:0051817;GO:0048518;GO:0065007;GO:0001906;GO:0051818;GO:0019724;GO:0060255;GO:2000257;GO:0030162;GO:0002673;GO:0051701;GO:0051704;GO:0009605;GO:0019538;GO:0002376;GO:0030449;GO:0002920;GO:0019835;GO:0019836;GO:0002684;GO:0002682;GO:0065008;GO:0006952;GO:0006950;GO:0006956;GO:0006957;GO:0006954;GO:0006955;GO:0002526;GO:0006958;GO:0006959;GO:0070613;GO:0051604;GO:0050896;GO:0031640;GO:0002697;GO:0008150;GO:1903317;GO:0001907;GO:0008152;GO:0032101;GO:0009611;GO:0044699;GO:0016064;GO:0044364;GO:0051246;GO:0006508;GO:1903034;GO:0009987;GO:0016485;GO:0001897;GO:0052331;GO:0050776;GO:0002460;GO:0050778;GO:0043170;GO:0080134;GO:0072376;GO:0044179;GO:0002443;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0002449;GO:0044764;GO:0044004;GO:0044003;GO:0044238;GO:0051883;GO:0035821;GO:0002250;GO:0002253;GO:0002252;GO:0044403;GO:0051801; regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;cytolysis in other organism;single-organism metabolic process;regulation of inflammatory response;interspecies interaction between organisms;modification of morphology or physiology of other organism involved in symbiotic interaction;positive regulation of biological process;biological regulation;cell killing;disruption of cells of other organism involved in symbiotic interaction;B cell mediated immunity;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of proteolysis;regulation of acute inflammatory response;interaction with host;multi-organism process;response to external stimulus;protein metabolic process;immune system process;regulation of complement activation;regulation of humoral immune response;cytolysis;hemolysis by symbiont of host erythrocytes;positive regulation of immune system process;regulation of immune system process;regulation of biological quality;defense response;response to stress;complement activation;complement activation, alternative pathway;inflammatory response;immune response;acute inflammatory response;complement activation, classical pathway;humoral immune response;regulation of protein processing;protein maturation;response to stimulus;killing of cells of other organism;regulation of immune effector process;biological_process;regulation of protein maturation;killing by symbiont of host cells;metabolic process;regulation of response to external stimulus;response to wounding;single-organism process;immunoglobulin mediated immune response;disruption of cells of other organism;regulation of protein metabolic process;proteolysis;regulation of response to wounding;cellular process;protein processing;cytolysis by symbiont of host cells;hemolysis in other organism involved in symbiotic interaction;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of immune response;macromolecule metabolic process;regulation of response to stress;protein activation cascade;hemolysis in other organism;leukocyte mediated immunity;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;lymphocyte mediated immunity;multi-organism cellular process;disruption by symbiont of host cell;modification by symbiont of host morphology or physiology;primary metabolic process;killing of cells in other organism involved in symbiotic interaction;modification of morphology or physiology of other organism;adaptive immune response;activation of immune response;immune effector process;symbiosis, encompassing mutualism through parasitism;cytolysis in other organism involved in symbiotic interaction; 4;3;3;3;5;5;4;3;5;3;4;2;2;2;5;6;4;4;6;6;4;2;3;4;2;5;5;3;6;3;3;3;4;3;4;5;5;3;6;5;4;7;5;2;3;4;1;6;5;2;4;4;2;7;4;5;5;5;2;6;6;5;4;5;4;4;4;3;5;4;2;3;5;5;4;5;3;6;5;3;4;3;4;3;3;4;5; GO:0031982;GO:0016021;GO:0016020;GO:0043234;GO:0043230;GO:0044424;GO:0044425;GO:0044421;GO:0005622;GO:0043227;GO:0043226;GO:0072562;GO:0031224;GO:0031226;GO:0005737;GO:0046930;GO:0044459;GO:0044464;GO:0005623;GO:0071944;GO:0098797;GO:0070062;GO:0005887;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0098796;GO:0005576;GO:0005579; vesicle;integral component of membrane;membrane;protein complex;extracellular organelle;intracellular part;membrane part;extracellular region part;intracellular;membrane-bounded organelle;organelle;blood microparticle;intrinsic component of membrane;intrinsic component of plasma membrane;cytoplasm;pore complex;plasma membrane part;cell part;cell;cell periphery;plasma membrane protein complex;extracellular exosome;integral component of plasma membrane;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;membrane protein complex;extracellular region;membrane attack complex; 4;4;2;3;3;3;2;2;3;3;2;3;3;4;4;4;3;2;2;3;4;4;4;3;3;3;2;1;3;2;5; K04000 map04610;map05020;map05146;map05322; Complement and coagulation cascades;Prion diseases;Amoebiasis;Systemic lupus erythematosus; IPR016186;IPR023415;IPR002172;IPR009030;IPR020864;IPR020863;IPR001862;IPR000884; C-type lectin-like/link domain;Low-density lipoprotein (LDL) receptor class A, conserved site;Low-density lipoprotein (LDL) receptor class A repeat;Growth factor receptor cysteine-rich domain;Membrane attack complex component/perforin (MACPF) domain;Membrane attack complex component/perforin domain, conserved site;Membrane attack complex component/perforin/complement C9;Thrombospondin type-1 (TSP1) repeat; extracellular O15229 Kynurenine 3-monooxygenase OS=Homo sapiens OX=9606 GN=KMO PE=1 SV=2 - [KMO_HUMAN] 0.715 0.714 1.846 0.733 0.901 0.922 1.00140056 0.466884637 0.813540511 0.035341554 2.585434174 5.51E-07 1.023307436 0.439007904 GO:0034354;GO:0043436;GO:0009165;GO:0044281;GO:0044282;GO:0044283;GO:1901362;GO:1901360;GO:1901361;GO:0044712;GO:0044710;GO:0044711;GO:0044550;GO:0043650;GO:0042537;GO:0019359;GO:0042402;GO:0046874;GO:0032787;GO:0009074;GO:1901564;GO:0009072;GO:0046483;GO:0043648;GO:0006575;GO:1901566;GO:0016054;GO:0016053;GO:0019439;GO:0019438;GO:0009063;GO:0006807;GO:1901576;GO:1901575;GO:0051186;GO:0070189;GO:0051188;GO:0006569;GO:0006568;GO:0018130;GO:0009308;GO:0006586;GO:0019637;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0042436;GO:0090407;GO:0019805;GO:0044271;GO:0044270;GO:0046394;GO:0046395;GO:0050896;GO:1901293;GO:0009117;GO:0006753;GO:0006576;GO:1901565;GO:0019674;GO:0006732;GO:0006733;GO:0009310;GO:0044248;GO:0044249;GO:0034641;GO:0009651;GO:0044699;GO:0006139;GO:0042430;GO:1901605;GO:1901606;GO:0009628;GO:0009987;GO:0006725;GO:0044106;GO:0055086;GO:0006082;GO:0046700;GO:0046496;GO:0019752;GO:0009435;GO:0034627;GO:0009108;GO:0072524;GO:0072525;GO:0006520;GO:0043420;GO:0071704;GO:0019441;GO:0019748;GO:0009058;GO:0044763;GO:0046218;GO:0009056;GO:0044238;GO:0042180;GO:0044237;GO:0006796;GO:0006793;GO:0006970;GO:0019363;GO:0019362; 'de novo' NAD biosynthetic process from tryptophan;oxoacid metabolic process;nucleotide biosynthetic process;small molecule metabolic process;small molecule catabolic process;small molecule biosynthetic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;secondary metabolite biosynthetic process;dicarboxylic acid biosynthetic process;benzene-containing compound metabolic process;nicotinamide nucleotide biosynthetic process;cellular biogenic amine catabolic process;quinolinate metabolic process;monocarboxylic acid metabolic process;aromatic amino acid family catabolic process;organonitrogen compound metabolic process;aromatic amino acid family metabolic process;heterocycle metabolic process;dicarboxylic acid metabolic process;cellular modified amino acid metabolic process;organonitrogen compound biosynthetic process;organic acid catabolic process;organic acid biosynthetic process;aromatic compound catabolic process;aromatic compound biosynthetic process;cellular amino acid catabolic process;nitrogen compound metabolic process;organic substance biosynthetic process;organic substance catabolic process;cofactor metabolic process;kynurenine metabolic process;cofactor biosynthetic process;tryptophan catabolic process;tryptophan metabolic process;heterocycle biosynthetic process;amine metabolic process;indolalkylamine metabolic process;organophosphate metabolic process;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;indole-containing compound catabolic process;organophosphate biosynthetic process;quinolinate biosynthetic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;carboxylic acid biosynthetic process;carboxylic acid catabolic process;response to stimulus;nucleoside phosphate biosynthetic process;nucleotide metabolic process;nucleoside phosphate metabolic process;cellular biogenic amine metabolic process;organonitrogen compound catabolic process;NAD metabolic process;coenzyme metabolic process;oxidoreduction coenzyme metabolic process;amine catabolic process;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;response to salt stress;single-organism process;nucleobase-containing compound metabolic process;indole-containing compound metabolic process;alpha-amino acid metabolic process;alpha-amino acid catabolic process;response to abiotic stimulus;cellular process;cellular aromatic compound metabolic process;cellular amine metabolic process;nucleobase-containing small molecule metabolic process;organic acid metabolic process;heterocycle catabolic process;nicotinamide nucleotide metabolic process;carboxylic acid metabolic process;NAD biosynthetic process;'de novo' NAD biosynthetic process;coenzyme biosynthetic process;pyridine-containing compound metabolic process;pyridine-containing compound biosynthetic process;cellular amino acid metabolic process;anthranilate metabolic process;organic substance metabolic process;tryptophan catabolic process to kynurenine;secondary metabolic process;biosynthetic process;single-organism cellular process;indolalkylamine catabolic process;catabolic process;primary metabolic process;cellular ketone metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;response to osmotic stress;pyridine nucleotide biosynthetic process;pyridine nucleotide metabolic process; 7;5;6;4;5;5;5;4;5;4;3;4;5;7;5;8;7;6;7;6;4;5;4;7;4;5;5;5;5;5;5;3;4;4;4;5;5;7;6;5;5;6;4;3;1;2;5;6;5;7;5;5;6;6;2;5;6;5;6;5;8;5;6;6;4;4;4;5;2;4;5;5;6;3;2;4;5;4;4;5;7;6;9;10;6;5;6;4;6;3;6;4;3;3;7;3;3;4;3;5;4;4;7;6; GO:0031975;GO:0031982;GO:0031968;GO:0098588;GO:0031967;GO:0043230;GO:0043231;GO:0044429;GO:0044421;GO:0044422;GO:0019866;GO:0043229;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0044425;GO:0044446;GO:0044444;GO:0016020;GO:0031090;GO:0005739;GO:0005623;GO:0044464;GO:0019867;GO:0005622;GO:0005743;GO:0005740;GO:0005741;GO:0016021;GO:0005829;GO:0044424;GO:0070062;GO:0098805;GO:0031966;GO:1903561;GO:0005575;GO:0005576; envelope;vesicle;organelle outer membrane;bounding membrane of organelle;organelle envelope;extracellular organelle;intracellular membrane-bounded organelle;mitochondrial part;extracellular region part;organelle part;organelle inner membrane;intracellular organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;membrane part;intracellular organelle part;cytoplasmic part;membrane;organelle membrane;mitochondrion;cell;cell part;outer membrane;intracellular;mitochondrial inner membrane;mitochondrial envelope;mitochondrial outer membrane;integral component of membrane;cytosol;intracellular part;extracellular exosome;whole membrane;mitochondrial membrane;extracellular vesicle;cellular_component;extracellular region; 3;4;4;4;4;3;4;4;2;2;4;3;3;2;3;4;2;3;4;2;3;5;2;2;3;3;5;5;5;4;5;3;4;3;4;3;1;2; GO:0004497;GO:1901363;GO:0000166;GO:0016174;GO:0003674;GO:0005488;GO:1901265;GO:0003824;GO:0043167;GO:0016491;GO:0043168;GO:0016709;GO:0016705;GO:0048037;GO:0016651;GO:0097159;GO:0071949;GO:0050662;GO:0050660;GO:0050664;GO:0036094;GO:0004502; monooxygenase activity;heterocyclic compound binding;nucleotide binding;NAD(P)H oxidase activity;molecular_function;binding;nucleoside phosphate binding;catalytic activity;ion binding;oxidoreductase activity;anion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;cofactor binding;oxidoreductase activity, acting on NAD(P)H;organic cyclic compound binding;FAD binding;coenzyme binding;flavin adenine dinucleotide binding;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor;small molecule binding;kynurenine 3-monooxygenase activity; 4;3;4;6;1;2;4;2;3;3;4;5;4;3;4;3;6;4;5;5;3;6; K00486 map00380;map01100; Tryptophan metabolism;Metabolic pathways; IPR002938;IPR027545;IPR023753; FAD-binding domain;Kynurenine 3-monooxygenase;FAD/NAD(P)-binding domain; plasma membrane Hs4504891 1016.0 CR [C] Energy production and conversion;[R] General function prediction only; Q5VWQ8 Disabled homolog 2-interacting protein OS=Homo sapiens OX=9606 GN=DAB2IP PE=1 SV=2 - [DAB2P_HUMAN] 1.11 1.184 0.797 1.035 1.118 0.985 0.9375 nan 0.925760286 nan 0.673141892 nan 0.881037567 nan GO:0033157;GO:0051169;GO:0034260;GO:0051049;GO:0016358;GO:2000736;GO:0044255;GO:0051716;GO:0014031;GO:0032434;GO:0043207;GO:0032435;GO:0000165;GO:0032386;GO:0032387;GO:0048468;GO:0045859;GO:0048731;GO:0046330;GO:0071364;GO:0050678;GO:0097485;GO:0022029;GO:0046483;GO:0042325;GO:0042327;GO:0042326;GO:0009607;GO:0010631;GO:0010632;GO:0010633;GO:0019538;GO:0030111;GO:1903896;GO:1903894;GO:0051272;GO:0009896;GO:0009894;GO:0009895;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0051254;GO:0035414;GO:1901342;GO:1901343;GO:0031175;GO:0071902;GO:0035556;GO:0071900;GO:0051224;GO:0050789;GO:0000904;GO:0051347;GO:0051346;GO:0051345;GO:0006886;GO:0051348;GO:0043410;GO:0002684;GO:0002682;GO:0071840;GO:0018130;GO:0070201;GO:0006629;GO:1903649;GO:0032075;GO:0007050;GO:0021543;GO:0043412;GO:0016070;GO:0060070;GO:0071345;GO:0071347;GO:0010557;GO:0010556;GO:0048869;GO:0043393;GO:0010558;GO:0034142;GO:0048147;GO:0048145;GO:0046578;GO:0051129;GO:0051128;GO:1903827;GO:0090129;GO:0042176;GO:0042177;GO:0038127;GO:1903362;GO:1903726;GO:0006955;GO:1903828;GO:0038084;GO:1904019;GO:0000122;GO:0009653;GO:0060284;GO:0021799;GO:0002224;GO:0002221;GO:0021795;GO:0008285;GO:0008286;GO:0035239;GO:0008283;GO:0021537;GO:0043124;GO:0070317;GO:0007409;GO:0044257;GO:0048010;GO:0070316;GO:0016525;GO:2000181;GO:0060341;GO:0030030;GO:0097190;GO:0097191;GO:0097193;GO:0022402;GO:0008219;GO:0007275;GO:0009888;GO:0002218;GO:0033993;GO:2000112;GO:2000113;GO:0043065;GO:0043067;GO:0006511;GO:2000145;GO:0043068;GO:0090090;GO:0006468;GO:0006469;GO:0045089;GO:0045088;GO:0032496;GO:0019216;GO:0019219;GO:0006606;GO:0045087;GO:0006461;GO:0090317;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0060485;GO:0040011;GO:0045184;GO:0051271;GO:0051270;GO:0048858;GO:0040017;GO:0010596;GO:0048856;GO:0001837;GO:0035295;GO:0006796;GO:2000026;GO:0006793;GO:0048523;GO:0048522;GO:0008104;GO:0032147;GO:0031349;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0090287;GO:0031344;GO:0031346;GO:0044710;GO:0045786;GO:0045787;GO:0070849;GO:0070848;GO:0045664;GO:0045666;GO:0044093;GO:0044092;GO:0033036;GO:0051056;GO:0006935;GO:0051051;GO:0071396;GO:0051058;GO:2001141;GO:0051707;GO:0010033;GO:0051704;GO:0044248;GO:0009605;GO:0030968;GO:0044249;GO:1904029;GO:0070887;GO:0022030;GO:0010629;GO:0006807;GO:0001764;GO:0046328;GO:0010647;GO:0044267;GO:0044265;GO:0002764;GO:0044260;GO:0002768;GO:0001568;GO:0044344;GO:0007049;GO:0006366;GO:0043408;GO:0034612;GO:0021814;GO:0090219;GO:0050793;GO:0050790;GO:0009889;GO:0021819;GO:0050794;GO:1904589;GO:0060074;GO:0051239;GO:0051234;GO:0051336;GO:1902679;GO:0010719;GO:0070059;GO:0010717;GO:0050896;GO:0010498;GO:0051338;GO:0032088;GO:0051962;GO:0051960;GO:0046822;GO:0046823;GO:2000147;GO:2000146;GO:1900101;GO:1900103;GO:0010562;GO:0008054;GO:0032069;GO:0033673;GO:0051241;GO:0070271;GO:0010564;GO:0051173;GO:0051247;GO:0043407;GO:0043406;GO:0043405;GO:1903533;GO:0044699;GO:0032880;GO:0050767;GO:0051248;GO:0071375;GO:0051240;GO:0010563;GO:0051246;GO:0031098;GO:0050769;GO:0010769;GO:0031399;GO:1901700;GO:1902593;GO:0070302;GO:0072594;GO:0034122;GO:0040013;GO:0070304;GO:0034121;GO:0040012;GO:1901701;GO:0014065;GO:0014067;GO:0014066;GO:0090132;GO:0090130;GO:0090288;GO:1902680;GO:0002237;GO:0033365;GO:0035411;GO:0070373;GO:0070372;GO:0070371;GO:0043933;GO:0035412;GO:0001525;GO:0071901;GO:0051223;GO:0021700;GO:0030178;GO:0071158;GO:1901652;GO:0071156;GO:1903364;GO:0045935;GO:0045934;GO:0030182;GO:0045936;GO:0061136;GO:0042221;GO:0022008;GO:0007264;GO:0008347;GO:0000902;GO:0044238;GO:0044237;GO:2001235;GO:0019220;GO:2000737;GO:0019222;GO:2001233;GO:0048585;GO:0048584;GO:0048583;GO:0072359;GO:0060322;GO:1901362;GO:1901360;GO:0031330;GO:0048863;GO:0048864;GO:0009968;GO:0009966;GO:0009967;GO:0007265;GO:0048513;GO:0048514;GO:0010720;GO:0010721;GO:0048518;GO:0048519;GO:0043122;GO:0002683;GO:0042127;GO:0048762;GO:0038179;GO:0006605;GO:0051090;GO:0007173;GO:0043434;GO:0045023;GO:0043433;GO:0044700;GO:0044707;GO:0010243;GO:0016055;GO:0002376;GO:0033554;GO:0019637;GO:0035924;GO:0060828;GO:0006927;GO:0022607;GO:0033674;GO:1902547;GO:0006928;GO:0051674;GO:0042981;GO:0097659;GO:0043542;GO:0090068;GO:0043547;GO:0043549;GO:0009719;GO:1904031;GO:1904030;GO:0031347;GO:0071219;GO:0071216;GO:0016477;GO:0048646;GO:0061564;GO:0034097;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:0006954;GO:0042308;GO:1902532;GO:0042306;GO:1902531;GO:0048015;GO:0048017;GO:1900181;GO:1900180;GO:0002757;GO:0072577;GO:0007420;GO:0046907;GO:0031400;GO:0031401;GO:0002758;GO:0040008;GO:0006355;GO:0006357;GO:1900747;GO:0006351;GO:1900744;GO:0032774;GO:0000186;GO:0030154;GO:0048011;GO:1902533;GO:1904950;GO:0008543;GO:0043632;GO:0006139;GO:0007254;GO:0008625;GO:0007252;GO:0043161;GO:0032270;GO:0006508;GO:0032502;GO:0006644;GO:0032501;GO:1901799;GO:0051603;GO:1903052;GO:0031331;GO:1903050;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0032872;GO:0032870;GO:0032874;GO:0044744;GO:0032879;GO:0016482;GO:0050776;GO:0071363;GO:0050773;GO:0051253;GO:0051252;GO:0050778;GO:0050673;GO:0035967;GO:0035966;GO:0010771;GO:0021801;GO:0080134;GO:0034620;GO:0034504;GO:0080135;GO:0071222;GO:0042059;GO:0042058;GO:0032869;GO:0043506;GO:0043507;GO:0021987;GO:1900006;GO:0045765;GO:0032989;GO:0071704;GO:0071310;GO:0048812;GO:0022603;GO:0071702;GO:2000598;GO:2000599;GO:1900746;GO:0030336;GO:0030335;GO:0030334;GO:0034613;GO:0006913;GO:0051174;GO:0009058;GO:0009059;GO:0051170;GO:0051171;GO:0051172;GO:0051649;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0051726;GO:0000079;GO:0071495;GO:0030900;GO:1901653;GO:1902582;GO:1902580;GO:0034654;GO:0071417;GO:0006915;GO:0030163;GO:0080090;GO:0050680;GO:0023014;GO:0006987;GO:0006986;GO:0010605;GO:0010604;GO:0042330;GO:0070727;GO:0009617;GO:1904590;GO:0045833;GO:0048144;GO:0060255;GO:0030162;GO:0010976;GO:0010975;GO:0090128;GO:0048870;GO:0021885;GO:0019438;GO:1903650;GO:0038066;GO:0009057;GO:1901185;GO:1901576;GO:1901575;GO:0045937;GO:0071356;GO:1903363;GO:0016043;GO:0065003;GO:0065007;GO:1901800;GO:2001222;GO:0065009;GO:0065008;GO:0043409;GO:2001224;GO:0051130;GO:0007257;GO:0042063;GO:0034144;GO:0036211;GO:0008150;GO:0008152;GO:0034143;GO:1903725;GO:0043254;GO:0043551;GO:0043550;GO:0043553;GO:0038095;GO:0038093;GO:0001944;GO:0030947;GO:0030948;GO:1901698;GO:1901699;GO:0043497;GO:0045732;GO:0045737;GO:0045736;GO:0071774;GO:0050808;GO:0050803;GO:0016310;GO:0050807;GO:0044271;GO:0035148;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0007411;GO:0001667;GO:0010646;GO:0043087;GO:0043086;GO:0043085;GO:0007417;GO:0072358;GO:0036324;GO:0017038;GO:0045597;GO:0045596;GO:0045595;GO:0045892;GO:0045893;GO:0051093;GO:0032269;GO:0032268;GO:0051094;GO:0009725;GO:0046580;GO:0051098;GO:0007249;GO:0043170;GO:0010628;GO:0045944;GO:0045862;GO:0045861;GO:0045860;GO:0034976;GO:0000187;GO:0038026;GO:0000185;GO:0031329;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0010948;GO:0010942;GO:0032868;GO:0010941;GO:1901184;GO:0040007;GO:0071822;GO:0070555;GO:1903508;GO:0010467;GO:1902548;GO:0010468;GO:0048666;GO:0048667;GO:1903051;GO:0019941;GO:0036498;GO:0051403;GO:0007154;GO:0048699;GO:0032990;GO:0007399;GO:0022604;GO:0010594;GO:0044087;GO:0044085;GO:0002253;GO:0015031;GO:0001933;GO:0001932;GO:0001934; regulation of intracellular protein transport;nuclear transport;negative regulation of GTPase activity;regulation of transport;dendrite development;regulation of stem cell differentiation;cellular lipid metabolic process;cellular response to stimulus;mesenchymal cell development;regulation of proteasomal ubiquitin-dependent protein catabolic process;response to external biotic stimulus;negative regulation of proteasomal ubiquitin-dependent protein catabolic process;MAPK cascade;regulation of intracellular transport;negative regulation of intracellular transport;cell development;regulation of protein kinase activity;system development;positive regulation of JNK cascade;cellular response to epidermal growth factor stimulus;regulation of epithelial cell proliferation;neuron projection guidance;telencephalon cell migration;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;negative regulation of phosphorylation;response to biotic stimulus;epithelial cell migration;regulation of epithelial cell migration;negative regulation of epithelial cell migration;protein metabolic process;regulation of Wnt signaling pathway;positive regulation of IRE1-mediated unfolded protein response;regulation of IRE1-mediated unfolded protein response;positive regulation of cellular component movement;positive regulation of catabolic process;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;negative regulation of catenin import into nucleus;regulation of vasculature development;negative regulation of vasculature development;neuron projection development;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;negative regulation of protein transport;regulation of biological process;cell morphogenesis involved in differentiation;positive regulation of transferase activity;negative regulation of hydrolase activity;positive regulation of hydrolase activity;intracellular protein transport;negative regulation of transferase activity;positive regulation of MAPK cascade;positive regulation of immune system process;regulation of immune system process;cellular component organization or biogenesis;heterocycle biosynthetic process;regulation of establishment of protein localization;lipid metabolic process;regulation of cytoplasmic transport;positive regulation of nuclease activity;cell cycle arrest;pallium development;macromolecule modification;RNA metabolic process;canonical Wnt signaling pathway;cellular response to cytokine stimulus;cellular response to interleukin-1;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;cellular developmental process;regulation of protein binding;negative regulation of macromolecule biosynthetic process;toll-like receptor 4 signaling pathway;negative regulation of fibroblast proliferation;regulation of fibroblast proliferation;regulation of Ras protein signal transduction;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;positive regulation of synapse maturation;regulation of protein catabolic process;negative regulation of protein catabolic process;ERBB signaling pathway;regulation of cellular protein catabolic process;negative regulation of phospholipid metabolic process;immune response;negative regulation of cellular protein localization;vascular endothelial growth factor signaling pathway;epithelial cell apoptotic process;negative regulation of transcription from RNA polymerase II promoter;anatomical structure morphogenesis;regulation of cell development;cerebral cortex radially oriented cell migration;toll-like receptor signaling pathway;pattern recognition receptor signaling pathway;cerebral cortex cell migration;negative regulation of cell proliferation;insulin receptor signaling pathway;tube morphogenesis;cell proliferation;telencephalon development;negative regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of G0 to G1 transition;axonogenesis;cellular protein catabolic process;vascular endothelial growth factor receptor signaling pathway;regulation of G0 to G1 transition;negative regulation of angiogenesis;negative regulation of blood vessel morphogenesis;regulation of cellular localization;cell projection organization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;intrinsic apoptotic signaling pathway;cell cycle process;cell death;multicellular organism development;tissue development;activation of innate immune response;response to lipid;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;positive regulation of apoptotic process;regulation of programmed cell death;ubiquitin-dependent protein catabolic process;regulation of cell motility;positive regulation of programmed cell death;negative regulation of canonical Wnt signaling pathway;protein phosphorylation;negative regulation of protein kinase activity;positive regulation of innate immune response;regulation of innate immune response;response to lipopolysaccharide;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;protein import into nucleus;innate immune response;protein complex assembly;negative regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;mesenchyme development;locomotion;establishment of protein localization;negative regulation of cellular component movement;regulation of cellular component movement;cell projection morphogenesis;positive regulation of locomotion;negative regulation of endothelial cell migration;anatomical structure development;epithelial to mesenchymal transition;tube development;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;protein localization;activation of protein kinase activity;positive regulation of defense response;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of cellular response to growth factor stimulus;regulation of cell projection organization;positive regulation of cell projection organization;single-organism metabolic process;negative regulation of cell cycle;positive regulation of cell cycle;response to epidermal growth factor;response to growth factor;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of molecular function;negative regulation of molecular function;macromolecule localization;regulation of small GTPase mediated signal transduction;chemotaxis;negative regulation of transport;cellular response to lipid;negative regulation of small GTPase mediated signal transduction;regulation of RNA biosynthetic process;response to other organism;response to organic substance;multi-organism process;cellular catabolic process;response to external stimulus;endoplasmic reticulum unfolded protein response;cellular biosynthetic process;regulation of cyclin-dependent protein kinase activity;cellular response to chemical stimulus;telencephalon glial cell migration;negative regulation of gene expression;nitrogen compound metabolic process;neuron migration;regulation of JNK cascade;positive regulation of cell communication;cellular protein metabolic process;cellular macromolecule catabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;immune response-regulating cell surface receptor signaling pathway;blood vessel development;cellular response to fibroblast growth factor stimulus;cell cycle;transcription from RNA polymerase II promoter;regulation of MAPK cascade;response to tumor necrosis factor;cell motility involved in cerebral cortex radial glia guided migration;negative regulation of lipid kinase activity;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;layer formation in cerebral cortex;regulation of cellular process;regulation of protein import;synapse maturation;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;negative regulation of RNA biosynthetic process;negative regulation of epithelial to mesenchymal transition;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;regulation of epithelial to mesenchymal transition;response to stimulus;proteasomal protein catabolic process;regulation of transferase activity;negative regulation of NF-kappaB transcription factor activity;positive regulation of nervous system development;regulation of nervous system development;regulation of nucleocytoplasmic transport;negative regulation of nucleocytoplasmic transport;positive regulation of cell motility;negative regulation of cell motility;regulation of endoplasmic reticulum unfolded protein response;positive regulation of endoplasmic reticulum unfolded protein response;positive regulation of phosphorus metabolic process;negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation;regulation of nuclease activity;negative regulation of kinase activity;negative regulation of multicellular organismal process;protein complex biogenesis;regulation of cell cycle process;positive regulation of nitrogen compound metabolic process;positive regulation of protein metabolic process;negative regulation of MAP kinase activity;positive regulation of MAP kinase activity;regulation of MAP kinase activity;regulation of protein targeting;single-organism process;regulation of protein localization;regulation of neurogenesis;negative regulation of protein metabolic process;cellular response to peptide hormone stimulus;positive regulation of multicellular organismal process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;positive regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;response to oxygen-containing compound;single-organism nuclear import;regulation of stress-activated protein kinase signaling cascade;establishment of protein localization to organelle;negative regulation of toll-like receptor signaling pathway;negative regulation of locomotion;positive regulation of stress-activated protein kinase signaling cascade;regulation of toll-like receptor signaling pathway;regulation of locomotion;cellular response to oxygen-containing compound;phosphatidylinositol 3-kinase signaling;negative regulation of phosphatidylinositol 3-kinase signaling;regulation of phosphatidylinositol 3-kinase signaling;epithelium migration;tissue migration;negative regulation of cellular response to growth factor stimulus;positive regulation of RNA biosynthetic process;response to molecule of bacterial origin;protein localization to organelle;catenin import into nucleus;negative regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;macromolecular complex subunit organization;regulation of catenin import into nucleus;angiogenesis;negative regulation of protein serine/threonine kinase activity;regulation of protein transport;developmental maturation;negative regulation of Wnt signaling pathway;positive regulation of cell cycle arrest;response to peptide;regulation of cell cycle arrest;positive regulation of cellular protein catabolic process;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;neuron differentiation;negative regulation of phosphate metabolic process;regulation of proteasomal protein catabolic process;response to chemical;neurogenesis;small GTPase mediated signal transduction;glial cell migration;cell morphogenesis;primary metabolic process;cellular metabolic process;positive regulation of apoptotic signaling pathway;regulation of phosphate metabolic process;negative regulation of stem cell differentiation;regulation of metabolic process;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;head development;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of cellular catabolic process;stem cell differentiation;stem cell development;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;Ras protein signal transduction;animal organ development;blood vessel morphogenesis;positive regulation of cell development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of I-kappaB kinase/NF-kappaB signaling;negative regulation of immune system process;regulation of cell proliferation;mesenchymal cell differentiation;neurotrophin signaling pathway;protein targeting;regulation of sequence-specific DNA binding transcription factor activity;epidermal growth factor receptor signaling pathway;response to peptide hormone;G0 to G1 transition;negative regulation of sequence-specific DNA binding transcription factor activity;single organism signaling;single-multicellular organism process;response to organonitrogen compound;Wnt signaling pathway;immune system process;cellular response to stress;organophosphate metabolic process;cellular response to vascular endothelial growth factor stimulus;regulation of canonical Wnt signaling pathway;transformed cell apoptotic process;cellular component assembly;positive regulation of kinase activity;regulation of cellular response to vascular endothelial growth factor stimulus;movement of cell or subcellular component;localization of cell;regulation of apoptotic process;nucleic acid-templated transcription;endothelial cell migration;positive regulation of cell cycle process;positive regulation of GTPase activity;regulation of kinase activity;response to endogenous stimulus;positive regulation of cyclin-dependent protein kinase activity;negative regulation of cyclin-dependent protein kinase activity;regulation of defense response;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;cell migration;anatomical structure formation involved in morphogenesis;axon development;response to cytokine;transport;defense response;programmed cell death;response to stress;inflammatory response;negative regulation of protein import into nucleus;negative regulation of intracellular signal transduction;regulation of protein import into nucleus;regulation of intracellular signal transduction;phosphatidylinositol-mediated signaling;inositol lipid-mediated signaling;negative regulation of protein localization to nucleus;regulation of protein localization to nucleus;immune response-activating signal transduction;endothelial cell apoptotic process;brain development;intracellular transport;negative regulation of protein modification process;positive regulation of protein modification process;innate immune response-activating signal transduction;regulation of growth;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;negative regulation of vascular endothelial growth factor signaling pathway;transcription, DNA-templated;regulation of p38MAPK cascade;RNA biosynthetic process;activation of MAPKK activity;cell differentiation;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;negative regulation of establishment of protein localization;fibroblast growth factor receptor signaling pathway;modification-dependent macromolecule catabolic process;nucleobase-containing compound metabolic process;JNK cascade;extrinsic apoptotic signaling pathway via death domain receptors;I-kappaB phosphorylation;proteasome-mediated ubiquitin-dependent protein catabolic process;positive regulation of cellular protein metabolic process;proteolysis;developmental process;phospholipid metabolic process;multicellular organismal process;negative regulation of proteasomal protein catabolic process;proteolysis involved in cellular protein catabolic process;positive regulation of proteolysis involved in cellular protein catabolic process;positive regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;regulation of stress-activated MAPK cascade;cellular response to hormone stimulus;positive regulation of stress-activated MAPK cascade;protein targeting to nucleus;regulation of localization;cytosolic transport;regulation of immune response;cellular response to growth factor stimulus;regulation of dendrite development;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of immune response;epithelial cell proliferation;cellular response to topologically incorrect protein;response to topologically incorrect protein;negative regulation of cell morphogenesis involved in differentiation;cerebral cortex radial glia guided migration;regulation of response to stress;cellular response to unfolded protein;protein localization to nucleus;regulation of cellular response to stress;cellular response to lipopolysaccharide;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;cellular response to insulin stimulus;regulation of JUN kinase activity;positive regulation of JUN kinase activity;cerebral cortex development;positive regulation of dendrite development;regulation of angiogenesis;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;neuron projection morphogenesis;regulation of anatomical structure morphogenesis;organic substance transport;regulation of cyclin catabolic process;negative regulation of cyclin catabolic process;regulation of vascular endothelial growth factor signaling pathway;negative regulation of cell migration;positive regulation of cell migration;regulation of cell migration;cellular protein localization;nucleocytoplasmic transport;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;nuclear import;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;catabolic process;localization;single-organism localization;cellular localization;regulation of cell cycle;regulation of cyclin-dependent protein serine/threonine kinase activity;cellular response to endogenous stimulus;forebrain development;cellular response to peptide;single-organism intracellular transport;single-organism cellular localization;nucleobase-containing compound biosynthetic process;cellular response to organonitrogen compound;apoptotic process;protein catabolic process;regulation of primary metabolic process;negative regulation of epithelial cell proliferation;signal transduction by protein phosphorylation;activation of signaling protein activity involved in unfolded protein response;response to unfolded protein;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;taxis;cellular macromolecule localization;response to bacterium;negative regulation of protein import;negative regulation of lipid metabolic process;fibroblast proliferation;regulation of macromolecule metabolic process;regulation of proteolysis;positive regulation of neuron projection development;regulation of neuron projection development;regulation of synapse maturation;cell motility;forebrain cell migration;aromatic compound biosynthetic process;negative regulation of cytoplasmic transport;p38MAPK cascade;macromolecule catabolic process;negative regulation of ERBB signaling pathway;organic substance biosynthetic process;organic substance catabolic process;positive regulation of phosphate metabolic process;cellular response to tumor necrosis factor;negative regulation of cellular protein catabolic process;cellular component organization;macromolecular complex assembly;biological regulation;positive regulation of proteasomal protein catabolic process;regulation of neuron migration;regulation of molecular function;regulation of biological quality;negative regulation of MAPK cascade;positive regulation of neuron migration;positive regulation of cellular component organization;activation of JUN kinase activity;gliogenesis;negative regulation of toll-like receptor 4 signaling pathway;protein modification process;biological_process;metabolic process;regulation of toll-like receptor 4 signaling pathway;regulation of phospholipid metabolic process;regulation of protein complex assembly;regulation of phosphatidylinositol 3-kinase activity;regulation of lipid kinase activity;negative regulation of phosphatidylinositol 3-kinase activity;Fc-epsilon receptor signaling pathway;Fc receptor signaling pathway;vasculature development;regulation of vascular endothelial growth factor receptor signaling pathway;negative regulation of vascular endothelial growth factor receptor signaling pathway;response to nitrogen compound;cellular response to nitrogen compound;regulation of protein heterodimerization activity;positive regulation of protein catabolic process;positive regulation of cyclin-dependent protein serine/threonine kinase activity;negative regulation of cyclin-dependent protein serine/threonine kinase activity;response to fibroblast growth factor;synapse organization;regulation of synapse structure or activity;phosphorylation;regulation of synapse organization;cellular nitrogen compound biosynthetic process;tube formation;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;axon guidance;ameboidal-type cell migration;regulation of cell communication;regulation of GTPase activity;negative regulation of catalytic activity;positive regulation of catalytic activity;central nervous system development;cardiovascular system development;vascular endothelial growth factor receptor-2 signaling pathway;protein import;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;positive regulation of developmental process;response to hormone;negative regulation of Ras protein signal transduction;regulation of binding;I-kappaB kinase/NF-kappaB signaling;macromolecule metabolic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of proteolysis;negative regulation of proteolysis;positive regulation of protein kinase activity;response to endoplasmic reticulum stress;activation of MAPK activity;reelin-mediated signaling pathway;activation of MAPKKK activity;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;negative regulation of cell cycle process;positive regulation of cell death;response to insulin;regulation of cell death;regulation of ERBB signaling pathway;growth;protein complex subunit organization;response to interleukin-1;positive regulation of nucleic acid-templated transcription;gene expression;negative regulation of cellular response to vascular endothelial growth factor stimulus;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;negative regulation of proteolysis involved in cellular protein catabolic process;modification-dependent protein catabolic process;IRE1-mediated unfolded protein response;stress-activated MAPK cascade;cell communication;generation of neurons;cell part morphogenesis;nervous system development;regulation of cell morphogenesis;regulation of endothelial cell migration;regulation of cellular component biogenesis;cellular component biogenesis;activation of immune response;protein transport;negative regulation of protein phosphorylation;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 6;6;3;4;4;5;4;3;6;8;4;8;5;5;4;4;7;4;8;5;5;5;5;4;7;7;7;3;6;4;4;4;5;6;6;4;4;4;4;3;3;4;4;5;6;5;4;5;9;5;8;4;2;5;6;6;6;6;6;6;3;3;2;5;5;4;6;5;5;4;5;5;7;6;7;5;5;4;5;5;8;5;5;7;4;4;5;5;5;5;8;6;5;3;3;8;7;7;3;5;6;7;6;5;4;8;4;3;4;6;6;7;6;8;6;5;5;4;4;5;6;6;4;4;4;4;4;5;6;6;6;5;8;4;5;6;7;8;5;5;5;5;5;5;4;5;4;6;3;4;3;5;2;4;4;4;5;3;5;3;6;4;5;4;4;3;3;4;9;4;4;5;6;7;4;5;5;3;4;4;4;5;7;6;4;4;3;6;4;3;6;6;6;3;4;2;4;3;5;4;5;4;6;5;3;5;7;4;5;5;5;4;6;4;5;4;7;6;6;4;5;3;4;4;4;3;6;5;3;3;5;6;4;6;5;2;6;5;6;4;5;7;6;4;4;5;5;5;6;5;7;3;4;5;4;5;7;7;7;7;2;4;6;5;6;3;5;5;5;5;6;6;4;6;5;5;4;3;6;5;3;5;8;6;6;5;4;4;6;5;6;6;7;7;6;4;7;4;9;5;4;5;6;5;6;6;5;5;6;6;7;3;6;6;5;5;3;3;5;6;5;3;5;3;3;3;5;4;5;4;5;6;5;4;4;4;7;4;4;5;5;2;2;6;3;4;6;6;6;4;9;5;5;5;3;3;4;6;2;4;4;7;6;7;4;7;5;4;3;6;7;7;5;7;6;3;6;6;5;5;4;4;3;6;5;4;4;5;3;5;5;5;6;5;7;6;4;6;4;8;4;5;6;6;5;3;6;7;5;6;7;6;7;5;7;5;3;6;6;4;7;7;7;7;5;5;2;5;2;7;6;7;5;7;2;4;7;7;6;5;7;5;3;6;4;6;5;5;5;4;4;5;4;5;7;4;6;7;4;6;6;6;7;8;8;4;5;5;4;3;5;6;4;5;7;6;5;5;5;5;5;7;5;3;5;8;4;4;4;3;2;3;3;4;6;4;4;6;5;4;5;5;6;5;4;5;4;6;5;4;4;3;4;4;5;4;4;4;6;6;6;6;3;5;5;5;7;5;5;4;4;6;7;6;3;5;2;7;6;3;3;6;6;4;8;7;5;5;1;2;6;6;4;7;6;6;8;7;5;5;5;4;5;6;5;5;5;4;4;4;6;5;5;4;3;3;4;2;4;5;3;6;5;4;6;5;5;5;5;9;5;4;4;4;6;6;3;5;5;3;4;7;4;6;4;5;7;6;6;8;5;8;6;7;5;5;5;5;4;4;4;5;5;4;6;4;5;2;5;6;7;5;5;5;5;6;7;7;6;6;4;7;5;5;5;5;3;3;3;5;7;7;7; GO:0044424;GO:0044425;GO:0044421;GO:0009898;GO:1990597;GO:0043025;GO:0031226;GO:0044463;GO:0044464;GO:0071944;GO:0070062;GO:1990032;GO:0016023;GO:0044298;GO:0044297;GO:0042995;GO:0043234;GO:0043230;GO:0005829;GO:0031235;GO:0098552;GO:0044301;GO:0044300;GO:0036477;GO:0098562;GO:0043229;GO:0005622;GO:0043226;GO:0031982;GO:0044444;GO:0016020;GO:0032809;GO:0005737;GO:0043005;GO:0030139;GO:0030425;GO:0030424;GO:0031988;GO:0043231;GO:0031224;GO:0097708;GO:0043227;GO:0033267;GO:0031410;GO:0044459;GO:0005623;GO:0097458;GO:0005576;GO:0005886;GO:1903561;GO:0032991;GO:0005575; intracellular part;membrane part;extracellular region part;cytoplasmic side of plasma membrane;AIP1-IRE1 complex;neuronal cell body;intrinsic component of plasma membrane;cell projection part;cell part;cell periphery;extracellular exosome;parallel fiber;cytoplasmic, membrane-bounded vesicle;cell body membrane;cell body;cell projection;protein complex;extracellular organelle;cytosol;intrinsic component of the cytoplasmic side of the plasma membrane;side of membrane;climbing fiber;cerebellar mossy fiber;somatodendritic compartment;cytoplasmic side of membrane;intracellular organelle;intracellular;organelle;vesicle;cytoplasmic part;membrane;neuronal cell body membrane;cytoplasm;neuron projection;endocytic vesicle;dendrite;axon;membrane-bounded vesicle;intracellular membrane-bounded organelle;intrinsic component of membrane;intracellular vesicle;membrane-bounded organelle;axon part;cytoplasmic vesicle;plasma membrane part;cell;neuron part;extracellular region;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component; 3;2;2;4;4;4;4;3;2;3;4;5;5;4;3;3;3;3;5;5;3;6;6;4;4;3;3;2;4;4;2;4;4;4;6;5;5;5;4;3;4;3;4;5;3;2;3;2;3;3;2;1; GO:0098772;GO:0005488;GO:1901981;GO:0071889;GO:0008289;GO:0017124;GO:0043184;GO:0046983;GO:0019902;GO:0005543;GO:0032813;GO:0070273;GO:0019899;GO:0032403;GO:0005515;GO:0005102;GO:0008047;GO:0031435;GO:0031434;GO:0035591;GO:0005096;GO:0019901;GO:0019900;GO:0019903;GO:0003674;GO:0043548;GO:0043167;GO:0042802;GO:0042803;GO:0035091;GO:0030234;GO:0051721;GO:0060090;GO:0044877;GO:0030695;GO:0019904;GO:0005126;GO:0005123;GO:0036312;GO:0043168;GO:0060589;GO:0032266;GO:0005172;GO:0070851; molecular function regulator;binding;phosphatidylinositol phosphate binding;14-3-3 protein binding;lipid binding;SH3 domain binding;vascular endothelial growth factor receptor 2 binding;protein dimerization activity;phosphatase binding;phospholipid binding;tumor necrosis factor receptor superfamily binding;phosphatidylinositol-4-phosphate binding;enzyme binding;protein complex binding;protein binding;receptor binding;enzyme activator activity;mitogen-activated protein kinase kinase kinase binding;mitogen-activated protein kinase kinase binding;signaling adaptor activity;GTPase activator activity;protein kinase binding;kinase binding;protein phosphatase binding;molecular_function;phosphatidylinositol 3-kinase binding;ion binding;identical protein binding;protein homodimerization activity;phosphatidylinositol binding;enzyme regulator activity;protein phosphatase 2A binding;binding, bridging;macromolecular complex binding;GTPase regulator activity;protein domain specific binding;cytokine receptor binding;death receptor binding;phosphatidylinositol 3-kinase regulatory subunit binding;anion binding;nucleoside-triphosphatase regulator activity;phosphatidylinositol-3-phosphate binding;vascular endothelial growth factor receptor binding;growth factor receptor binding; 2;2;6;4;3;5;7;4;5;4;6;7;4;4;3;4;4;7;7;4;5;6;5;6;1;4;3;4;5;5;3;7;3;3;5;4;5;7;5;4;4;7;6;5; K19901 map04210;map04668; Apoptosis;TNF signaling pathway; IPR021887;IPR030403;IPR001936;IPR023315;IPR008936;IPR023152;IPR001849;IPR011993;IPR000008; Domain of unknown function DUF3498;Disabled homologue 2-interacting protein;Ras GTPase-activating protein;SynGAP C2 domain, N-terminal;Rho GTPase activation protein;Ras GTPase-activating protein, conserved site;Pleckstrin homology domain;PH domain-like;C2 domain; nucleus Hs20070109 1977.0 R [R] General function prediction only; Q8TF72 Protein Shroom3 OS=Homo sapiens OX=9606 GN=SHROOM3 PE=1 SV=2 - [SHRM3_HUMAN] 0.443 0.37 3.047 0.415 0.468 0.839 1.197297297 0.012864457 0.886752137 0.022667392 8.235135135 1.94E-10 1.792735043 4.25E-05 GO:0008105;GO:0008104;GO:0048468;GO:0032989;GO:0071840;GO:0051716;GO:0048869;GO:0030855;GO:0033036;GO:0002064;GO:0008360;GO:0035148;GO:0014020;GO:0044707;GO:0009605;GO:0022604;GO:0022603;GO:0050789;GO:0000902;GO:0016043;GO:0065007;GO:0001841;GO:0001843;GO:0065008;GO:0048646;GO:0050793;GO:0009888;GO:0050794;GO:0060606;GO:0008150;GO:0050896;GO:0030154;GO:0051128;GO:0009790;GO:0009792;GO:0009653;GO:0044699;GO:0045176;GO:0043482;GO:0060562;GO:0043009;GO:0032502;GO:0032501;GO:0035239;GO:0060429;GO:0043473;GO:0043476;GO:0048731;GO:0016331;GO:0072175;GO:0007275;GO:0007389;GO:0033059;GO:0048729;GO:0048598;GO:0009987;GO:0021915;GO:0002009;GO:0044767;GO:0044763;GO:0035295;GO:0051179;GO:0001838;GO:0007399;GO:0048856; asymmetric protein localization;protein localization;cell development;cellular component morphogenesis;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;epithelial cell differentiation;macromolecule localization;epithelial cell development;regulation of cell shape;tube formation;primary neural tube formation;single-multicellular organism process;response to external stimulus;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;regulation of biological process;cell morphogenesis;cellular component organization;biological regulation;neural tube formation;neural tube closure;regulation of biological quality;anatomical structure formation involved in morphogenesis;regulation of developmental process;tissue development;regulation of cellular process;tube closure;biological_process;response to stimulus;cell differentiation;regulation of cellular component organization;embryo development;embryo development ending in birth or egg hatching;anatomical structure morphogenesis;single-organism process;apical protein localization;cellular pigment accumulation;epithelial tube morphogenesis;chordate embryonic development;developmental process;multicellular organismal process;tube morphogenesis;epithelium development;pigmentation;pigment accumulation;system development;morphogenesis of embryonic epithelium;epithelial tube formation;multicellular organism development;pattern specification process;cellular pigmentation;tissue morphogenesis;embryonic morphogenesis;cellular process;neural tube development;morphogenesis of an epithelium;single-organism developmental process;single-organism cellular process;tube development;localization;embryonic epithelial tube formation;nervous system development;anatomical structure development; 5;4;4;4;2;3;4;6;3;5;4;4;6;3;3;5;4;2;5;3;2;5;6;3;3;3;4;3;5;1;2;5;4;5;6;3;2;6;4;5;7;2;2;4;5;3;4;4;5;5;4;4;4;4;4;2;4;5;3;3;4;2;6;5;3; GO:0099512;GO:0099513;GO:0016020;GO:0098589;GO:0015630;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043232;GO:0043229;GO:0043228;GO:0005856;GO:0044430;GO:0030054;GO:0070161;GO:0044446;GO:0005874;GO:0005737;GO:0045177;GO:0044459;GO:0016324;GO:0005912;GO:0005911;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098805;GO:0043226;GO:0005886;GO:0005575;GO:0043296; supramolecular fiber;polymeric cytoskeletal fiber;membrane;membrane region;microtubule cytoskeleton;intracellular part;membrane part;organelle part;plasma membrane region;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cytoskeleton;cytoskeletal part;cell junction;anchoring junction;intracellular organelle part;microtubule;cytoplasm;apical part of cell;plasma membrane part;apical plasma membrane;adherens junction;cell-cell junction;cell part;cell;intracellular;cell periphery;whole membrane;organelle;plasma membrane;cellular_component;apical junction complex; 2;3;2;3;6;3;2;2;4;4;3;3;5;4;2;3;3;4;4;3;3;4;4;3;2;2;3;3;3;2;3;1;4; K18625 map04530; Tight junction; IPR001478;IPR030494;IPR027685;IPR014799;IPR014800; PDZ domain;Shroom3;Shroom family;Apx/Shrm Domain 2;Apx/Shrm Domain 1; nucleus P33993 DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4 - [MCM7_HUMAN] 1.471 0.83 0.764 1.209 1.017 0.815 1.772289157 nan 1.18879056 nan 0.920481928 nan 0.801376598 nan GO:0019220;GO:0019222;GO:0000082;GO:1901360;GO:0051716;GO:0022616;GO:0071840;GO:0070849;GO:0070848;GO:0006260;GO:0006261;GO:0006268;GO:0032392;GO:0010033;GO:0046483;GO:0006270;GO:0033554;GO:0006271;GO:0071103;GO:0070887;GO:0042493;GO:1901576;GO:0044260;GO:0016043;GO:0009719;GO:0065007;GO:0007049;GO:0042325;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0051174;GO:0050896;GO:0016310;GO:0044249;GO:0034641;GO:0034645;GO:0042221;GO:0044699;GO:0006139;GO:0071495;GO:0008283;GO:0032508;GO:0009987;GO:0006725;GO:0006974;GO:0090304;GO:0071364;GO:0071363;GO:0043170;GO:0006807;GO:0031323;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:0009410;GO:0071466;GO:0050789;GO:0071704;GO:0071310;GO:0000278;GO:0009058;GO:0009059;GO:0044763;GO:0044843;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0006796;GO:0006793;GO:0006259; regulation of phosphate metabolic process;regulation of metabolic process;G1/S transition of mitotic cell cycle;organic cyclic compound metabolic process;cellular response to stimulus;DNA strand elongation;cellular component organization or biogenesis;response to epidermal growth factor;response to growth factor;DNA replication;DNA-dependent DNA replication;DNA unwinding involved in DNA replication;DNA geometric change;response to organic substance;heterocycle metabolic process;DNA replication initiation;cellular response to stress;DNA strand elongation involved in DNA replication;DNA conformation change;cellular response to chemical stimulus;response to drug;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;response to endogenous stimulus;biological regulation;cell cycle;regulation of phosphorylation;regulation of cellular process;response to stress;biological_process;metabolic process;regulation of phosphorus metabolic process;response to stimulus;phosphorylation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;response to chemical;single-organism process;nucleobase-containing compound metabolic process;cellular response to endogenous stimulus;cell proliferation;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;nucleic acid metabolic process;cellular response to epidermal growth factor stimulus;cellular response to growth factor stimulus;macromolecule metabolic process;nitrogen compound metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;response to xenobiotic stimulus;cellular response to xenobiotic stimulus;regulation of biological process;organic substance metabolic process;cellular response to organic substance;mitotic cell cycle;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cell cycle G1/S phase transition;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;DNA metabolic process; 6;3;7;4;3;6;2;4;5;6;7;8;7;4;4;6;4;7;6;4;4;4;4;3;3;2;4;7;3;3;1;2;5;2;6;4;4;5;3;2;4;4;3;8;2;4;5;5;5;6;4;3;4;5;5;6;4;4;5;2;3;5;5;3;5;3;6;4;3;5;3;5;4;5; GO:0031974;GO:0031981;GO:0016020;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0000781;GO:0043229;GO:0043228;GO:0000784;GO:0000228;GO:0005622;GO:0043227;GO:0043226;GO:0042555;GO:0005654;GO:0098687;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0044454;GO:0044464;GO:0005623;GO:0000785;GO:0005694;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;chromosomal part;organelle part;chromosome, telomeric region;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome, telomeric region;nuclear chromosome;intracellular;membrane-bounded organelle;organelle;MCM complex;nucleoplasm;chromosomal region;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nuclear chromosome part;cell part;cell;chromatin;chromosome;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;2;3;4;4;3;5;4;3;4;2;6;3;3;6;5;3;3;2;4;5;5;3;4;4;5;5;2;2;3;5;2;1;4; GO:1901363;GO:0000166;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0003676;GO:0003677;GO:0003678;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0003697;GO:0030554;GO:0005488;GO:0001883;GO:0001882;GO:0017111;GO:0036094;GO:0043168; heterocyclic compound binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;nucleic acid binding;DNA binding;DNA helicase activity;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;single-stranded DNA binding;adenyl nucleotide binding;binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;anion binding; 3;4;8;5;3;4;1;4;5;9;4;5;5;6;3;2;3;6;6;5;6;4;5;3;6;6;2;5;4;7;3;4; K02210 map03030;map04110;map04111;map04113; DNA replication;Cell cycle;Cell cycle - yeast;Meiosis - yeast; IPR031327;IPR033762;IPR018525;IPR003593;IPR027925;IPR027417;IPR001208;IPR008050;IPR012340; Mini-chromosome maintenance protein;MCM OB domain;Mini-chromosome maintenance, conserved site;AAA+ ATPase domain;MCM N-terminal domain;P-loop containing nucleoside triphosphate hydrolase;MCM domain;DNA replication licensing factor Mcm7;Nucleic acid-binding, OB-fold; nucleus Hs21359886 1483.0 L [L] Replication, recombination and repair; P33991 DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5 - [MCM4_HUMAN] 1.606 1.244 0.422 1.147 1.075 0.331 1.290996785 nan 1.066976744 nan 0.339228296 nan 0.307906977 nan GO:0000082;GO:0071840;GO:0006260;GO:0006261;GO:0006268;GO:0032392;GO:0046483;GO:0006271;GO:0006270;GO:0071103;GO:0006807;GO:1901576;GO:0044260;GO:0016043;GO:0044699;GO:0008150;GO:0008152;GO:0044249;GO:0034641;GO:0034645;GO:0007049;GO:0006139;GO:0022616;GO:0032508;GO:0009987;GO:0006725;GO:0090304;GO:0043170;GO:1903047;GO:0044770;GO:0044772;GO:0022402;GO:1901360;GO:0071704;GO:0000278;GO:0009058;GO:0009059;GO:0044763;GO:0044843;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0006259; G1/S transition of mitotic cell cycle;cellular component organization or biogenesis;DNA replication;DNA-dependent DNA replication;DNA unwinding involved in DNA replication;DNA geometric change;heterocycle metabolic process;DNA strand elongation involved in DNA replication;DNA replication initiation;DNA conformation change;nitrogen compound metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;single-organism process;biological_process;metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;cell cycle;nucleobase-containing compound metabolic process;DNA strand elongation;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;nucleic acid metabolic process;macromolecule metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;cell cycle process;organic cyclic compound metabolic process;organic substance metabolic process;mitotic cell cycle;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cell cycle G1/S phase transition;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;DNA metabolic process; 7;2;6;7;8;7;4;7;6;6;3;4;4;3;2;1;2;4;4;5;4;4;6;8;2;4;5;4;5;5;6;4;4;3;5;3;5;3;6;4;3;5;3;5; GO:0031974;GO:0031981;GO:0016020;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0000781;GO:0043229;GO:0000784;GO:0000228;GO:0005622;GO:0043227;GO:0043226;GO:0042555;GO:0005654;GO:0098687;GO:0044446;GO:0005634;GO:0044454;GO:0044464;GO:0005623;GO:0043228;GO:0005694;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;chromosome, telomeric region;intracellular organelle;nuclear chromosome, telomeric region;nuclear chromosome;intracellular;membrane-bounded organelle;organelle;MCM complex;nucleoplasm;chromosomal region;intracellular organelle part;nucleus;nuclear chromosome part;cell part;cell;non-membrane-bounded organelle;chromosome;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;2;3;4;4;3;4;3;4;2;6;3;6;5;3;3;2;4;5;5;3;5;5;2;2;3;5;2;1;4; GO:1901363;GO:0000166;GO:0004386;GO:0003697;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0003676;GO:0003677;GO:0003678;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0043167;GO:0030554;GO:0005488;GO:0001883;GO:0001882;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;helicase activity;single-stranded DNA binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;nucleic acid binding;DNA binding;DNA helicase activity;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;ion binding;adenyl nucleotide binding;binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding; 3;4;8;6;5;3;4;1;4;5;9;4;5;5;6;3;2;3;6;6;5;6;4;5;4;3;6;2;5;4;7;3; K02212 map03030;map04110;map04111;map04113; DNA replication;Cell cycle;Cell cycle - yeast;Meiosis - yeast; IPR031327;IPR033762;IPR018525;IPR012340;IPR008047;IPR001208;IPR027925;IPR027417; Mini-chromosome maintenance protein;MCM OB domain;Mini-chromosome maintenance, conserved site;Nucleic acid-binding, OB-fold;Mini-chromosome maintenance complex protein 4;MCM domain;MCM N-terminal domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs14738665 1783.0 L [L] Replication, recombination and repair; Q9Y4E1 WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=4 - [WAC2C_HUMAN] 1.096 1.064 0.869 1.187 0.898 1.363 1.030075188 0.916235591 1.321826281 0.053793982 0.816729323 0.38483787 1.517817372 0.081387099 GO:0008104;GO:0034446;GO:1990126;GO:0048468;GO:0008064;GO:0032989;GO:0071840;GO:0065003;GO:0048869;GO:0051495;GO:0051493;GO:0048518;GO:0048519;GO:0033036;GO:0031589;GO:1901881;GO:1901880;GO:0045184;GO:0030041;GO:0030042;GO:0016197;GO:0016192;GO:0010638;GO:0010639;GO:0031333;GO:0022604;GO:0022607;GO:0022603;GO:1901879;GO:2000813;GO:2000812;GO:0000904;GO:0000902;GO:0016043;GO:0070271;GO:0065007;GO:0043243;GO:0065008;GO:0051130;GO:0098602;GO:0050793;GO:0006810;GO:0050794;GO:0008154;GO:0008150;GO:0042147;GO:0043254;GO:0051234;GO:0046907;GO:0090066;GO:0032535;GO:0022411;GO:1900024;GO:0032956;GO:0051494;GO:0033043;GO:0030155;GO:0030154;GO:0051129;GO:0051128;GO:0043244;GO:0009653;GO:0043241;GO:0044699;GO:0043242;GO:0060284;GO:0010769;GO:0032271;GO:0032272;GO:0032273;GO:0051693;GO:0022610;GO:0032502;GO:0009987;GO:0031334;GO:0045595;GO:0016482;GO:0051258;GO:0044087;GO:0007034;GO:0043933;GO:0030036;GO:0034622;GO:0030832;GO:0030833;GO:0030834;GO:0030835;GO:0071822;GO:0030837;GO:0030838;GO:0051261;GO:0050789;GO:0071702;GO:0032970;GO:0030029;GO:0010810;GO:0006461;GO:0032984;GO:0051016;GO:0044767;GO:0044765;GO:0044763;GO:0051649;GO:0007155;GO:0043624;GO:0043623;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0007015;GO:0007010;GO:0030836;GO:0048856;GO:1902589;GO:0044085;GO:0015031;GO:1902582;GO:0048522;GO:0048523;GO:0044089; protein localization;substrate adhesion-dependent cell spreading;retrograde transport, endosome to plasma membrane;cell development;regulation of actin polymerization or depolymerization;cellular component morphogenesis;cellular component organization or biogenesis;macromolecular complex assembly;cellular developmental process;positive regulation of cytoskeleton organization;regulation of cytoskeleton organization;positive regulation of biological process;negative regulation of biological process;macromolecule localization;cell-substrate adhesion;positive regulation of protein depolymerization;negative regulation of protein depolymerization;establishment of protein localization;actin filament polymerization;actin filament depolymerization;endosomal transport;vesicle-mediated transport;positive regulation of organelle organization;negative regulation of organelle organization;negative regulation of protein complex assembly;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;regulation of protein depolymerization;negative regulation of barbed-end actin filament capping;regulation of barbed-end actin filament capping;cell morphogenesis involved in differentiation;cell morphogenesis;cellular component organization;protein complex biogenesis;biological regulation;positive regulation of protein complex disassembly;regulation of biological quality;positive regulation of cellular component organization;single organism cell adhesion;regulation of developmental process;transport;regulation of cellular process;actin polymerization or depolymerization;biological_process;retrograde transport, endosome to Golgi;regulation of protein complex assembly;establishment of localization;intracellular transport;regulation of anatomical structure size;regulation of cellular component size;cellular component disassembly;regulation of substrate adhesion-dependent cell spreading;regulation of actin cytoskeleton organization;negative regulation of cytoskeleton organization;regulation of organelle organization;regulation of cell adhesion;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein complex disassembly;anatomical structure morphogenesis;protein complex disassembly;single-organism process;negative regulation of protein complex disassembly;regulation of cell development;regulation of cell morphogenesis involved in differentiation;regulation of protein polymerization;negative regulation of protein polymerization;positive regulation of protein polymerization;actin filament capping;biological adhesion;developmental process;cellular process;positive regulation of protein complex assembly;regulation of cell differentiation;cytosolic transport;protein polymerization;regulation of cellular component biogenesis;vacuolar transport;macromolecular complex subunit organization;actin cytoskeleton organization;cellular macromolecular complex assembly;regulation of actin filament length;regulation of actin filament polymerization;regulation of actin filament depolymerization;negative regulation of actin filament depolymerization;protein complex subunit organization;negative regulation of actin filament polymerization;positive regulation of actin filament polymerization;protein depolymerization;regulation of biological process;organic substance transport;regulation of actin filament-based process;actin filament-based process;regulation of cell-substrate adhesion;protein complex assembly;macromolecular complex disassembly;barbed-end actin filament capping;single-organism developmental process;single-organism transport;single-organism cellular process;establishment of localization in cell;cell adhesion;cellular protein complex disassembly;cellular protein complex assembly;localization;single-organism localization;cellular localization;organelle organization;actin filament organization;cytoskeleton organization;positive regulation of actin filament depolymerization;anatomical structure development;single-organism organelle organization;cellular component biogenesis;protein transport;single-organism intracellular transport;positive regulation of cellular process;negative regulation of cellular process;positive regulation of cellular component biogenesis; 4;4;6;4;6;4;2;5;4;6;6;2;2;3;4;6;6;4;8;8;7;5;5;5;5;5;4;4;6;5;7;5;5;3;4;2;5;3;4;3;3;4;3;7;1;6;4;3;5;4;4;4;5;5;6;5;4;5;4;4;5;3;6;2;5;5;6;5;6;5;8;2;2;2;4;4;6;7;3;6;4;5;6;5;6;7;7;5;7;6;8;2;5;4;4;5;5;5;9;3;4;3;4;3;7;6;2;3;3;4;6;5;7;3;4;3;5;5;3;3;3; GO:0031974;GO:0031981;GO:0005773;GO:0031901;GO:0043234;GO:0098588;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0071203;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0044437;GO:0005886;GO:0012505;GO:0010008;GO:0044446;GO:0044444;GO:0044440;GO:0005737;GO:0031090;GO:0005730;GO:0005634;GO:0032991;GO:0005774;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0016020;GO:0098805;GO:0005575;GO:0070013;GO:0005768;GO:0005769; membrane-enclosed lumen;nuclear lumen;vacuole;early endosome membrane;protein complex;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;WASH complex;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;vacuolar part;plasma membrane;endomembrane system;endosome membrane;intracellular organelle part;cytoplasmic part;endosomal part;cytoplasm;organelle membrane;nucleolus;nucleus;macromolecular complex;vacuolar membrane;cell part;cell;intracellular;cell periphery;membrane;whole membrane;cellular_component;intracellular organelle lumen;endosome;early endosome; 2;5;5;6;3;4;4;4;3;4;3;4;2;3;3;3;2;4;3;3;5;3;4;5;4;3;5;5;2;4;2;2;3;3;2;3;1;4;4;5; GO:0010314;GO:0005543;GO:0005546;GO:0005547;GO:0043325;GO:0003674;GO:0005488;GO:1902936;GO:0043168;GO:1901981;GO:0035091;GO:0070273;GO:0043167;GO:0080025;GO:0008289;GO:0032266; phosphatidylinositol-5-phosphate binding;phospholipid binding;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylinositol-3,4,5-trisphosphate binding;phosphatidylinositol-3,4-bisphosphate binding;molecular_function;binding;phosphatidylinositol bisphosphate binding;anion binding;phosphatidylinositol phosphate binding;phosphatidylinositol binding;phosphatidylinositol-4-phosphate binding;ion binding;phosphatidylinositol-3,5-bisphosphate binding;lipid binding;phosphatidylinositol-3-phosphate binding; 7;4;8;7;8;1;2;7;4;6;5;7;3;8;3;7; K18462 map04144; Endocytosis; IPR029341;IPR027308; FAM21/CAPZIP domain;WASH complex subunit 2; nucleus Hs22053296 2635.0 S [S] Function unknown; Q14839 Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2 - [CHD4_HUMAN] 0.492 0.512 2.608 0.534 0.448 1.683 0.9609375 nan 1.191964286 nan 5.09375 nan 3.756696429 nan GO:0080090;GO:0019222;GO:0050808;GO:1901362;GO:0071840;GO:0010605;GO:0048519;GO:0032392;GO:0060255;GO:2001141;GO:0046483;GO:0072553;GO:0019438;GO:0071103;GO:0022607;GO:0009892;GO:0009890;GO:0010629;GO:0006807;GO:0043170;GO:0051225;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0007051;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0006357;GO:0006351;GO:0010558;GO:0043044;GO:0032774;GO:0070271;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0000122;GO:0031327;GO:0032508;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051276;GO:0007049;GO:0006338;GO:0051253;GO:0051252;GO:0000226;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0022402;GO:0071822;GO:0006325;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045934;GO:0019219;GO:0006461;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0070925;GO:0016568;GO:0006996;GO:0044238;GO:0007017;GO:0007010;GO:0044237;GO:1902589;GO:0044085;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;synapse organization;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of macromolecule metabolic process;negative regulation of biological process;DNA geometric change;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;terminal button organization;aromatic compound biosynthetic process;DNA conformation change;cellular component assembly;negative regulation of metabolic process;negative regulation of biosynthetic process;negative regulation of gene expression;nitrogen compound metabolic process;macromolecule metabolic process;spindle assembly;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;spindle organization;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;ATP-dependent chromatin remodeling;RNA biosynthetic process;protein complex biogenesis;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of cellular biosynthetic process;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;chromosome organization;cell cycle;chromatin remodeling;negative regulation of RNA metabolic process;regulation of RNA metabolic process;microtubule cytoskeleton organization;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;protein complex subunit organization;chromatin organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;protein complex assembly;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;organelle assembly;chromatin modification;organelle organization;primary metabolic process;microtubule-based process;cytoskeleton organization;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;negative regulation of cellular process; 4;3;4;5;2;4;2;7;4;6;4;4;5;6;4;3;4;5;3;4;6;7;4;4;3;5;2;4;7;5;4;3;5;1;2;5;5;5;6;7;6;5;8;6;4;4;4;5;2;4;7;5;8;2;4;7;7;6;5;4;7;5;5;5;4;5;4;4;5;4;5;5;6;6;2;3;5;5;5;5;5;5;6;3;5;3;4;4;5;6;4;3;4;5;3;4;3;3; GO:0031974;GO:0005815;GO:0005654;GO:0031981;GO:0016020;GO:1902494;GO:0000790;GO:0090545;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0000228;GO:0043227;GO:0005856;GO:0044430;GO:0016581;GO:0044446;GO:0043226;GO:0005737;GO:0070603;GO:0005634;GO:0090568;GO:0044451;GO:0000118;GO:0032991;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0043228;GO:0044454;GO:0005813;GO:0005694;GO:0000785;GO:0015630;GO:0017053;GO:0032993;GO:0005575;GO:0070013; membrane-enclosed lumen;microtubule organizing center;nucleoplasm;nuclear lumen;membrane;catalytic complex;nuclear chromatin;CHD-type complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;nuclear chromosome;membrane-bounded organelle;cytoskeleton;cytoskeletal part;NuRD complex;intracellular organelle part;organelle;cytoplasm;SWI/SNF superfamily-type complex;nucleus;nuclear transcriptional repressor complex;nucleoplasm part;histone deacetylase complex;macromolecular complex;cell part;intracellular organelle;cell;intracellular;non-membrane-bounded organelle;nuclear chromosome part;centrosome;chromosome;chromatin;microtubule cytoskeleton;transcriptional repressor complex;protein-DNA complex;cellular_component;intracellular organelle lumen; 2;5;5;5;2;4;4;5;3;4;4;3;4;3;4;2;5;3;5;4;6;3;2;4;4;5;5;5;5;2;2;3;2;3;3;5;5;5;3;6;4;3;1;4; GO:0008270;GO:1901363;GO:0000166;GO:0046872;GO:0032549;GO:0008134;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0016787;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0003678;GO:0042623;GO:0017076;GO:0005524;GO:0043168;GO:0043169;GO:0036094;GO:0003824;GO:0097159;GO:0032559;GO:0032555;GO:0032553;GO:0008026;GO:0035639;GO:0043167;GO:0001085;GO:0008094;GO:0001103;GO:0030554;GO:0005515;GO:0016887;GO:0001883;GO:0001882;GO:0016462;GO:1901265;GO:0070491;GO:0004003;GO:0017111;GO:0046914;GO:0032550; zinc ion binding;heterocyclic compound binding;nucleotide binding;metal ion binding;ribonucleoside binding;transcription factor binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;hydrolase activity;molecular_function;binding;nucleic acid binding;DNA binding;DNA helicase activity;ATPase activity, coupled;purine nucleotide binding;ATP binding;anion binding;cation binding;small molecule binding;catalytic activity;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;ion binding;RNA polymerase II transcription factor binding;DNA-dependent ATPase activity;RNA polymerase II repressing transcription factor binding;adenyl nucleotide binding;protein binding;ATPase activity;purine nucleoside binding;nucleoside binding;pyrophosphatase activity;nucleoside phosphate binding;repressing transcription factor binding;ATP-dependent DNA helicase activity;nucleoside-triphosphatase activity;transition metal ion binding;purine ribonucleoside binding; 7;3;4;5;5;4;8;5;3;4;9;3;1;2;4;5;9;9;5;6;4;4;3;2;3;6;5;4;10;5;3;5;10;6;6;3;8;5;4;6;4;5;10;7;6;6; K11643 map05203; Viral carcinogenesis; IPR000330;IPR001965;IPR019787;IPR019786;IPR023780;IPR011011;IPR001650;IPR013083;IPR002464;IPR009462;IPR012957;IPR014001;IPR012958;IPR016197;IPR028725;IPR000953;IPR009463;IPR027417; SNF2-related, N-terminal domain;Zinc finger, PHD-type;Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;Chromo domain;Zinc finger, FYVE/PHD-type;Helicase, C-terminal;Zinc finger, RING/FYVE/PHD-type;DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;Domain of unknown function DUF1086;CHD, C-terminal 2;Helicase superfamily 1/2, ATP-binding domain;CHD, N-terminal;Chromo domain-like;Chromodomain-helicase-DNA-binding protein 4;Chromo/chromo shadow domain;Domain of unknown function DUF1087;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs4557453 3962.0 R [R] General function prediction only; Q49A26 Putative oxidoreductase GLYR1 OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4 - [GLYR1_HUMAN] 0.848 1.04 1.004 0.853 1.064 2.179 0.815384615 0.138327193 0.801691729 0.083739509 0.965384615 0.627206926 2.047932331 0.192935469 GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0031981;GO:0005634;GO:0005654;GO:0005794;GO:0044446;GO:0012505;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nuclear lumen;nucleus;nucleoplasm;Golgi apparatus;intracellular organelle part;endomembrane system;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part; 2;3;3;2;4;5;5;5;4;3;3;4;3;2;2;3;1;4;4;4;3;2; GO:0042393;GO:0035064;GO:0051287;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:1901265;GO:0016491;GO:0050662;GO:0000166;GO:0004616;GO:0036094;GO:0003824;GO:0048037;GO:0016614;GO:0016616;GO:0097159;GO:0005515; histone binding;methylated histone binding;NAD binding;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;nucleoside phosphate binding;oxidoreductase activity;coenzyme binding;nucleotide binding;phosphogluconate dehydrogenase (decarboxylating) activity;small molecule binding;catalytic activity;cofactor binding;oxidoreductase activity, acting on CH-OH group of donors;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;organic cyclic compound binding;protein binding; 4;5;5;3;1;2;4;5;4;3;4;4;6;3;2;3;4;5;3;3; IPR013328;IPR000313;IPR035501;IPR029154;IPR008927;IPR006115;IPR016040; 6-phosphogluconate dehydrogenase, domain 2;PWWP domain;NP60, PWWP domain;3-hydroxyisobutyrate dehydrogenase, NAD-binding domain;6-phosphogluconate dehydrogenase C-terminal domain-like;6-phosphogluconate dehydrogenase, NADP-binding;NAD(P)-binding domain; nucleus Hs20562150_2 698.0 R [R] General function prediction only; Q96LI5 CCR4-NOT transcription complex subunit 6-like OS=Homo sapiens OX=9606 GN=CNOT6L PE=1 SV=2 - [CNO6L_HUMAN] 0.776 0.444 2.691 0.605 0.476 0.332 1.747747748 0.022022166 1.271008403 0.468518795 6.060810811 0.001817907 0.697478992 0.589339576 GO:0080090;GO:0019222;GO:1901362;GO:0071840;GO:1901361;GO:0010603;GO:0010605;GO:0010606;GO:0010608;GO:0043043;GO:0016458;GO:0048518;GO:0048519;GO:0042127;GO:0006397;GO:0060255;GO:2001141;GO:0061157;GO:0046483;GO:1901564;GO:1901566;GO:0019538;GO:0010638;GO:0010558;GO:0019439;GO:0019438;GO:0022607;GO:0009892;GO:0009890;GO:0050779;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:1901575;GO:0044265;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:1901360;GO:0065008;GO:0018130;GO:0051130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0034655;GO:0046700;GO:0016070;GO:0016071;GO:0044271;GO:0044270;GO:0006355;GO:0010556;GO:0006351;GO:0006518;GO:0031047;GO:0034249;GO:0032774;GO:0033043;GO:0051128;GO:0044248;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0051248;GO:0000288;GO:0000289;GO:0043488;GO:0043487;GO:0051246;GO:0031327;GO:0022618;GO:0022613;GO:0008284;GO:0033962;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0034248;GO:0043604;GO:0032269;GO:0032268;GO:0043603;GO:0051252;GO:0010629;GO:0043170;GO:0000956;GO:0017148;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0034622;GO:0071826;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:1902115;GO:1902117;GO:0006401;GO:0006402;GO:0010468;GO:0044267;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0070925;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0044237;GO:0044087;GO:0044085;GO:0006396;GO:0006417;GO:0048522;GO:0006412;GO:0048523;GO:0044089; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;organic cyclic compound catabolic process;regulation of cytoplasmic mRNA processing body assembly;negative regulation of macromolecule metabolic process;positive regulation of cytoplasmic mRNA processing body assembly;posttranscriptional regulation of gene expression;peptide biosynthetic process;gene silencing;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;mRNA processing;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;mRNA destabilization;heterocycle metabolic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;positive regulation of organelle organization;negative regulation of macromolecule biosynthetic process;aromatic compound catabolic process;aromatic compound biosynthetic process;cellular component assembly;negative regulation of metabolic process;negative regulation of biosynthetic process;RNA destabilization;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;organic cyclic compound metabolic process;regulation of biological quality;heterocycle biosynthetic process;positive regulation of cellular component organization;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;nucleobase-containing compound catabolic process;heterocycle catabolic process;RNA metabolic process;mRNA metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;peptide metabolic process;gene silencing by RNA;negative regulation of cellular amide metabolic process;RNA biosynthetic process;regulation of organelle organization;regulation of cellular component organization;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;nuclear-transcribed mRNA poly(A) tail shortening;regulation of mRNA stability;regulation of RNA stability;regulation of protein metabolic process;negative regulation of cellular biosynthetic process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;positive regulation of cell proliferation;cytoplasmic mRNA processing body assembly;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular amide metabolic process;amide biosynthetic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;nuclear-transcribed mRNA catabolic process;negative regulation of translation;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;ribonucleoprotein complex subunit organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of organelle assembly;positive regulation of organelle assembly;RNA catabolic process;mRNA catabolic process;regulation of gene expression;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;organelle assembly;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;cellular metabolic process;regulation of cellular component biogenesis;cellular component biogenesis;RNA processing;regulation of translation;positive regulation of cellular process;translation;negative regulation of cellular process;positive regulation of cellular component biogenesis; 4;3;5;2;5;5;4;5;6;6;4;2;2;4;7;4;6;6;4;4;5;4;5;5;5;5;4;3;4;5;3;2;7;4;4;5;4;3;5;2;4;3;5;4;4;3;1;2;5;5;5;5;6;5;5;6;5;6;5;5;5;6;5;4;4;4;4;5;2;4;5;9;9;5;4;5;5;5;4;4;6;3;2;4;7;5;6;5;5;5;5;5;4;8;6;4;5;4;4;5;6;5;6;6;3;5;4;4;6;7;5;5;5;3;5;3;4;4;5;3;5;4;3;3;3;3;6;6;3;6;3;3; GO:0043234;GO:0043231;GO:0005829;GO:0030014;GO:0043229;GO:0005622;GO:0043227;GO:0044424;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0032991;GO:0005575; protein complex;intracellular membrane-bounded organelle;cytosol;CCR4-NOT complex;intracellular organelle;intracellular;membrane-bounded organelle;intracellular part;cytoplasmic part;cytoplasm;nucleus;cell part;cell;organelle;macromolecular complex;cellular_component; 3;4;5;4;3;3;3;3;4;4;5;2;2;2;2;1; GO:0046872;GO:0016896;GO:0003674;GO:0005488;GO:0004540;GO:0016787;GO:0043169;GO:0016788;GO:0003824;GO:0004535;GO:0004532;GO:0004527;GO:0016796;GO:0043167;GO:0004518;GO:0008408;GO:0000175; metal ion binding;exoribonuclease activity, producing 5'-phosphomonoesters;molecular_function;binding;ribonuclease activity;hydrolase activity;cation binding;hydrolase activity, acting on ester bonds;catalytic activity;poly(A)-specific ribonuclease activity;exoribonuclease activity;exonuclease activity;exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;ion binding;nuclease activity;3'-5' exonuclease activity;3'-5'-exoribonuclease activity; 5;8;1;2;6;3;4;4;2;9;7;6;7;3;5;7;8; K12603 map03018; RNA degradation; IPR003591;IPR032675;IPR005135;IPR034967;IPR001611; Leucine-rich repeat, typical subtype;Leucine-rich repeat domain, L domain-like;Endonuclease/exonuclease/phosphatase;CCR4-NOT transcription complex subunit 6-like;Leucine-rich repeat; cytosol Hs21687268 935.0 K [K] Transcription; Q9BW71 HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3 - [HIRP3_HUMAN] 1.234 1.068 0.815 1.045 1.03 1.106 1.155430712 nan 1.014563107 nan 0.763108614 nan 1.073786408 nan GO:0043933;GO:0071840;GO:0006325;GO:0016043;GO:0009987;GO:0008150;GO:0051276;GO:0006996;GO:0006333; macromolecular complex subunit organization;cellular component organization or biogenesis;chromatin organization;cellular component organization;cellular process;biological_process;chromosome organization;organelle organization;chromatin assembly or disassembly; 4;2;5;3;2;1;5;4;6; GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005575;GO:0031981;GO:0005730;GO:0005634;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cellular_component;nuclear lumen;nucleolus;nucleus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;3;3;2;1;5;5;5;4;4;3;2;2;3;3;4;4;3;2; IPR019098; Histone chaperone domain CHZ; nucleus Q99665 Interleukin-12 receptor subunit beta-2 OS=Homo sapiens OX=9606 GN=IL12RB2 PE=1 SV=1 - [I12R2_HUMAN] 1.252 1.007 0.841 1.09 1.095 0.784 1.243296922 nan 0.99543379 nan 0.835153923 nan 0.715981735 nan GO:0019221;GO:0007165;GO:0007166;GO:0051716;GO:0043207;GO:0009617;GO:0018212;GO:0018193;GO:0032729;GO:0048518;GO:0042127;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0009607;GO:0044707;GO:0009605;GO:0019538;GO:0032649;GO:0032496;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0034097;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0071345;GO:0050896;GO:0051239;GO:0016310;GO:0023052;GO:0070887;GO:0007154;GO:0044699;GO:0051240;GO:0008284;GO:0032501;GO:0008283;GO:0009987;GO:0043170;GO:0001816;GO:0001817;GO:0002237;GO:0001819;GO:0032609;GO:0018108;GO:0033993;GO:0006796;GO:0071704;GO:0071310;GO:0006468;GO:0006464;GO:0044763;GO:0042221;GO:1901700;GO:0044238;GO:0044237;GO:0006793;GO:0048522; cytokine-mediated signaling pathway;signal transduction;cell surface receptor signaling pathway;cellular response to stimulus;response to external biotic stimulus;response to bacterium;peptidyl-tyrosine modification;peptidyl-amino acid modification;positive regulation of interferon-gamma production;positive regulation of biological process;regulation of cell proliferation;response to other organism;response to organic substance;multi-organism process;single organism signaling;response to biotic stimulus;single-multicellular organism process;response to external stimulus;protein metabolic process;regulation of interferon-gamma production;response to lipopolysaccharide;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;response to cytokine;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;cellular response to cytokine stimulus;response to stimulus;regulation of multicellular organismal process;phosphorylation;signaling;cellular response to chemical stimulus;cell communication;single-organism process;positive regulation of multicellular organismal process;positive regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;macromolecule metabolic process;cytokine production;regulation of cytokine production;response to molecule of bacterial origin;positive regulation of cytokine production;interferon-gamma production;peptidyl-tyrosine phosphorylation;response to lipid;phosphate-containing compound metabolic process;organic substance metabolic process;cellular response to organic substance;protein phosphorylation;cellular protein modification process;single-organism cellular process;response to chemical;response to oxygen-containing compound;primary metabolic process;cellular metabolic process;phosphorus metabolic process;positive regulation of cellular process; 6;4;5;3;4;4;8;7;5;2;4;3;4;2;3;3;3;3;4;5;5;2;5;4;2;5;3;5;5;1;2;6;2;3;6;2;4;4;2;3;4;2;3;2;4;4;4;5;4;5;8;5;5;3;5;7;6;3;3;4;3;3;4;3; GO:0016021;GO:0044425;GO:0009897;GO:0031224;GO:0016020;GO:0031226;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0005887;GO:0005886;GO:0005575; integral component of membrane;membrane part;external side of plasma membrane;intrinsic component of membrane;membrane;intrinsic component of plasma membrane;plasma membrane part;cell surface;cell part;cell;cell periphery;side of membrane;integral component of plasma membrane;plasma membrane;cellular_component; 4;2;4;3;2;4;3;3;2;2;3;3;4;3;1; GO:0060089;GO:0004896;GO:0099600;GO:0003674;GO:0038023;GO:0004872;GO:0004871;GO:0004888; molecular transducer activity;cytokine receptor activity;transmembrane receptor activity;molecular_function;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity; 2;5;4;1;3;3;2;4; K05064 map04060;map04630;map05321; Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway;Inflammatory bowel disease (IBD); IPR003961;IPR013783;IPR010457;IPR003529; Fibronectin type III;Immunoglobulin-like fold;Immunoglobulin C2-set-like, ligand-binding;Long hematopoietin receptor, Gp130 family 2, conserved site; plasma membrane Q9H6T3 RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2 - [RPAP3_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0043234;GO:0005575;GO:0032991;GO:0097255; protein complex;cellular_component;macromolecular complex;R2TP complex; 3;1;2;4; K23002 IPR001440;IPR019734;IPR025986;IPR013026;IPR011990; Tetratricopeptide repeat 1;Tetratricopeptide repeat;RNA-polymerase II-associated protein 3-like, C-terminal domain;Tetratricopeptide repeat-containing domain;Tetratricopeptide-like helical domain; nucleus Hs13375809 1362.0 S [S] Function unknown; P43490 Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1 - [NAMPT_HUMAN] 0.641 0.765 1.782 0.6 1.028 1.29 0.837908497 0.020067848 0.583657588 0.000274318 2.329411765 3.51E-07 1.254863813 0.752719762 GO:0032922;GO:0080090;GO:0019222;GO:0009165;GO:1901362;GO:1901360;GO:0044710;GO:0044711;GO:0010604;GO:0048511;GO:0048518;GO:0019359;GO:0051704;GO:0042127;GO:0006767;GO:0006766;GO:0060255;GO:0006366;GO:0006769;GO:2001141;GO:0010033;GO:0046483;GO:0044700;GO:0044703;GO:1901564;GO:0044707;GO:1901566;GO:0044706;GO:0033002;GO:0019637;GO:0019438;GO:0044281;GO:0009893;GO:0009891;GO:0006807;GO:0051770;GO:1901576;GO:0051186;GO:0044260;GO:0051188;GO:0065007;GO:0014070;GO:0018130;GO:0007623;GO:0009889;GO:0051716;GO:0050794;GO:0051769;GO:0008152;GO:0034654;GO:0051767;GO:0090407;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0010557;GO:0010556;GO:1901293;GO:0048659;GO:0008150;GO:0006753;GO:0032774;GO:0019674;GO:0006732;GO:0006733;GO:0009117;GO:0044249;GO:0034641;GO:0023052;GO:0007165;GO:0034645;GO:0007154;GO:0000003;GO:0044699;GO:0006139;GO:0008284;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0055086;GO:0043603;GO:0007565;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0045944;GO:0046496;GO:1903508;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0009435;GO:0009108;GO:0072524;GO:0072525;GO:0009820;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0097659;GO:0010468;GO:0006351;GO:0045935;GO:0048660;GO:0048661;GO:0019219;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0007267;GO:0042221;GO:0044238;GO:0044237;GO:0006796;GO:0006793;GO:0048522;GO:0019363;GO:0019362; circadian regulation of gene expression;regulation of primary metabolic process;regulation of metabolic process;nucleotide biosynthetic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;positive regulation of macromolecule metabolic process;rhythmic process;positive regulation of biological process;nicotinamide nucleotide biosynthetic process;multi-organism process;regulation of cell proliferation;water-soluble vitamin metabolic process;vitamin metabolic process;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;nicotinamide metabolic process;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;single organism signaling;multi-organism reproductive process;organonitrogen compound metabolic process;single-multicellular organism process;organonitrogen compound biosynthetic process;multi-multicellular organism process;muscle cell proliferation;organophosphate metabolic process;aromatic compound biosynthetic process;small molecule metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;positive regulation of nitric-oxide synthase biosynthetic process;organic substance biosynthetic process;cofactor metabolic process;cellular macromolecule metabolic process;cofactor biosynthetic process;biological regulation;response to organic cyclic compound;heterocycle biosynthetic process;circadian rhythm;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;regulation of nitric-oxide synthase biosynthetic process;metabolic process;nucleobase-containing compound biosynthetic process;nitric-oxide synthase biosynthetic process;organophosphate biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;nucleoside phosphate biosynthetic process;smooth muscle cell proliferation;biological_process;nucleoside phosphate metabolic process;RNA biosynthetic process;NAD metabolic process;coenzyme metabolic process;oxidoreduction coenzyme metabolic process;nucleotide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;signal transduction;cellular macromolecule biosynthetic process;cell communication;reproduction;single-organism process;nucleobase-containing compound metabolic process;positive regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;nucleobase-containing small molecule metabolic process;cellular amide metabolic process;female pregnancy;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;nicotinamide nucleotide metabolic process;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;NAD biosynthetic process;coenzyme biosynthetic process;pyridine-containing compound metabolic process;pyridine-containing compound biosynthetic process;alkaloid metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;nucleic acid-templated transcription;regulation of gene expression;transcription, DNA-templated;positive regulation of nucleobase-containing compound metabolic process;regulation of smooth muscle cell proliferation;positive regulation of smooth muscle cell proliferation;regulation of nucleobase-containing compound metabolic process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell-cell signaling;response to chemical;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;positive regulation of cellular process;pyridine nucleotide biosynthetic process;pyridine nucleotide metabolic process; 4;4;3;6;5;4;3;4;4;2;2;8;2;4;6;5;4;7;4;6;4;4;3;3;4;3;5;3;4;4;5;4;3;4;3;6;4;4;4;5;2;5;5;3;4;3;3;6;2;5;6;5;5;5;2;6;5;5;5;5;1;5;6;8;5;6;6;4;4;2;4;5;4;2;2;4;4;2;3;2;4;7;6;4;5;4;5;5;4;6;5;7;7;7;5;5;4;4;5;9;6;5;6;5;6;2;3;5;7;7;5;6;5;5;5;5;2;3;5;3;4;4;4;3;3;3;5;4;3;7;6; GO:0031974;GO:0031981;GO:0043230;GO:0043233;GO:0030054;GO:0043231;GO:0044428;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0031982;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005829;GO:0044424;GO:0070062;GO:0044444;GO:1903561;GO:0005615;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;nuclear lumen;extracellular organelle;organelle lumen;cell junction;intracellular membrane-bounded organelle;nuclear part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;vesicle;intracellular organelle part;cytoplasm;nucleus;cell part;cell;cytosol;intracellular part;extracellular exosome;cytoplasmic part;extracellular vesicle;extracellular space;cellular_component;intracellular organelle lumen;extracellular region; 2;5;3;3;2;4;4;2;2;3;3;3;2;5;4;3;4;5;2;2;5;3;4;4;3;3;1;4;2; GO:0047280;GO:0016740;GO:0016757;GO:0005125;GO:0003674;GO:0005488;GO:0016763;GO:0003824;GO:0008144;GO:0004514;GO:0005515;GO:0005102; nicotinamide phosphoribosyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;cytokine activity;molecular_function;binding;transferase activity, transferring pentosyl groups;catalytic activity;drug binding;nicotinate-nucleotide diphosphorylase (carboxylating) activity;protein binding;receptor binding; 6;3;4;5;1;2;5;2;3;6;3;4; K03462 map00760;map01100; Nicotinate and nicotinamide metabolism;Metabolic pathways; IPR016471;IPR002638;IPR007229; Nicotinamide phosphoribosyl transferase;Quinolinate phosphoribosyl transferase, C-terminal;Nicotinate phosphoribosyltransferase family; cytosol 387793219 443.0 H [H] Coenzyme transport and metabolism; COG1488 Nicotinic acid phosphoribosyltransferase P35542 Serum amyloid A-4 protein OS=Homo sapiens OX=9606 GN=SAA4 PE=1 SV=2 - [SAA4_HUMAN] 1.04 0.892 1.186 1.022 0.912 0.893 1.165919283 0.00282374 1.120614035 0.005150257 1.329596413 2.00E-07 0.979166667 0.143130315 GO:0042221;GO:0060326;GO:0006928;GO:0051674;GO:0050918;GO:0070887;GO:0002526;GO:0044699;GO:0051716;GO:0042330;GO:0016477;GO:0006935;GO:0009987;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0006954;GO:0051179;GO:0040011;GO:0009605;GO:0048870;GO:0050896;GO:0044763; response to chemical;cell chemotaxis;movement of cell or subcellular component;localization of cell;positive chemotaxis;cellular response to chemical stimulus;acute inflammatory response;single-organism process;cellular response to stimulus;taxis;cell migration;chemotaxis;cellular process;defense response;acute-phase response;response to stress;biological_process;inflammatory response;localization;locomotion;response to external stimulus;cell motility;response to stimulus;single-organism cellular process; 3;5;4;3;5;4;6;2;3;3;4;4;2;4;7;3;1;5;2;2;3;3;2;3; GO:0034358;GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:0034364;GO:0032991;GO:1903561;GO:0031982;GO:0032994;GO:0043230;GO:0005575;GO:0005576;GO:1990777;GO:0044421; plasma lipoprotein particle;membrane-bounded organelle;organelle;extracellular exosome;extracellular space;high-density lipoprotein particle;macromolecular complex;extracellular vesicle;vesicle;protein-lipid complex;extracellular organelle;cellular_component;extracellular region;lipoprotein particle;extracellular region part; 3;3;2;4;3;4;2;3;4;3;3;1;2;4;2; GO:0042056;GO:0003674; chemoattractant activity;molecular_function; 2;1; K17310 IPR000096; Serum amyloid A protein; extracellular P01861 Immunoglobulin heavy constant gamma 4 OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=1 - [IGHG4_HUMAN] 0.982 1.137 0.867 0.841 1.272 0.834 0.863676341 7.99E-13 0.661163522 1.05E-53 0.762532982 1.87E-26 0.655660377 0.013016523 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0009617;GO:0048518;GO:0002682;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0050789;GO:0002764;GO:0002431;GO:0002768;GO:0002433;GO:0016043;GO:0002684;GO:0065007;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0006956;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0038096;GO:0038094;GO:0002757;GO:0006897;GO:0038093;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0008150;GO:0023052;GO:0044699;GO:0051234;GO:0008037;GO:0009987;GO:0050871;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0042742;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0072376;GO:0002443;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;response to bacterium;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;cellular component organization;positive regulation of immune system process;biological regulation;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;complement activation;metabolic process;immune response;complement activation, classical pathway;humoral immune response;Fc-gamma receptor signaling pathway involved in phagocytosis;Fc-gamma receptor signaling pathway;immune response-activating signal transduction;endocytosis;Fc receptor signaling pathway;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;biological_process;signaling;single-organism process;establishment of localization;cell recognition;cellular process;positive regulation of B cell activation;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;defense response to bacterium;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;4;2;3;6;4;3;3;2;3;5;5;3;4;2;3;2;5;6;6;4;3;3;2;4;3;3;4;3;7;4;2;3;5;4;5;8;4;6;7;2;4;4;4;1;2;2;3;4;2;6;4;4;5;5;4;5;4;5;4;6;4;5;3;4;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;5;3; GO:0031982;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0005623;GO:0043227;GO:0016020;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;cell;membrane-bounded organelle;membrane;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;3;3;2;2;4;2;3;2;3;4;3;3;2;3;3;4;2;3;3;3;2;1;2;3; GO:0005488;GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102; binding;molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding; 2;1;5;3;3;4; IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; mitochondria P01860 Immunoglobulin heavy constant gamma 3 OS=Homo sapiens OX=9606 GN=IGHG3 PE=1 SV=2 - [IGHG3_HUMAN] 1.329 0.782 0.905 1.12 0.837 0.936 1.699488491 1.68E-36 1.338112306 2.04E-24 1.157289003 2.18E-09 1.11827957 0.000148367 GO:0006909;GO:0060249;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0048518;GO:0002682;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0044707;GO:0019538;GO:0002376;GO:0050778;GO:0045321;GO:0050789;GO:0002764;GO:0002431;GO:0002768;GO:0002433;GO:0016043;GO:0002684;GO:0065007;GO:0065008;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0038096;GO:0038094;GO:0002757;GO:0006897;GO:0038093;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0006956;GO:0009617;GO:0023052;GO:0044699;GO:0051234;GO:0008037;GO:0032501;GO:0009987;GO:0050871;GO:0098542;GO:0001894;GO:0001895;GO:0050776;GO:0002460;GO:0051251;GO:0048871;GO:0010324;GO:0043170;GO:0042742;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0042592;GO:0072376;GO:0002443;GO:0071704;GO:0009605;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522; phagocytosis;anatomical structure homeostasis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;immune system process;positive regulation of immune response;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;cellular component organization;positive regulation of immune system process;biological regulation;regulation of biological quality;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;complement activation, classical pathway;humoral immune response;Fc-gamma receptor signaling pathway involved in phagocytosis;Fc-gamma receptor signaling pathway;immune response-activating signal transduction;endocytosis;Fc receptor signaling pathway;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;complement activation;response to bacterium;signaling;single-organism process;establishment of localization;cell recognition;multicellular organismal process;cellular process;positive regulation of B cell activation;defense response to other organism;tissue homeostasis;retina homeostasis;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;multicellular organismal homeostasis;membrane invagination;macromolecule metabolic process;defense response to bacterium;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;homeostatic process;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;response to external stimulus;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process; 5;5;3;3;4;4;5;5;2;3;4;2;3;6;4;3;3;2;3;5;5;3;4;2;4;3;2;5;6;6;4;3;3;2;3;4;3;3;4;3;7;1;2;3;5;4;5;8;4;6;7;2;4;4;4;4;4;2;2;3;4;2;2;6;4;5;6;4;5;5;4;5;4;5;4;6;4;5;4;3;4;3;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;5;3; GO:0031982;GO:0016020;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0005623;GO:0043227;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;membrane;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;cell;membrane-bounded organelle;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;2;3;3;2;2;4;2;3;3;4;3;3;2;3;3;4;2;3;3;3;2;1;2;3; GO:0005488;GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102; binding;molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding; 2;1;5;3;3;4; IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular Q2M1Z3 Rho GTPase-activating protein 31 OS=Homo sapiens OX=9606 GN=ARHGAP31 PE=1 SV=2 - [RHG31_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0048583;GO:0023052;GO:0007165;GO:0023051;GO:0035556;GO:0010646;GO:0050789;GO:0044699;GO:0051716;GO:1902531;GO:0009966;GO:0065007;GO:0051056;GO:0009987;GO:0050794;GO:0008150;GO:0007154;GO:0007264;GO:0044700;GO:0050896;GO:0044763; regulation of response to stimulus;signaling;signal transduction;regulation of signaling;intracellular signal transduction;regulation of cell communication;regulation of biological process;single-organism process;cellular response to stimulus;regulation of intracellular signal transduction;regulation of signal transduction;biological regulation;regulation of small GTPase mediated signal transduction;cellular process;regulation of cellular process;biological_process;cell communication;small GTPase mediated signal transduction;single organism signaling;response to stimulus;single-organism cellular process; 3;2;4;3;5;4;2;2;3;5;4;2;6;2;3;1;4;6;3;2;3; GO:0042995;GO:0030055;GO:0005737;GO:0005924;GO:0030054;GO:0070161;GO:0005925;GO:0030027;GO:0031252;GO:0005912;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0005829; cell projection;cell-substrate junction;cytoplasm;cell-substrate adherens junction;cell junction;anchoring junction;focal adhesion;lamellipodium;cell leading edge;adherens junction;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;cytosol; 3;3;4;4;2;3;5;4;3;4;2;2;3;1;4;3;5; GO:0098772;GO:0003674;GO:0030234;GO:0005096;GO:0030695;GO:0060589;GO:0008047; molecular function regulator;molecular_function;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;enzyme activator activity; 2;1;3;5;5;4;4; K20646 IPR008936;IPR000198; Rho GTPase activation protein;Rho GTPase-activating protein domain; nucleus Hs22045949 2928.0 T [T] Signal transduction mechanisms; O14981 TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2 - [BTAF1_HUMAN] 1.402 0.787 0.919 1.23 0.87 1.017 1.781448539 nan 1.413793103 nan 1.16772554 nan 1.168965517 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0044092;GO:0048519;GO:0060255;GO:2001141;GO:0035561;GO:0035562;GO:0046483;GO:0019438;GO:0051098;GO:0009892;GO:0009890;GO:0051100;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0065009;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051253;GO:0051252;GO:0010629;GO:0043170;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0006355;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;negative regulation of molecular function;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;regulation of chromatin binding;negative regulation of chromatin binding;heterocycle metabolic process;aromatic compound biosynthetic process;regulation of binding;negative regulation of metabolic process;negative regulation of biosynthetic process;negative regulation of binding;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;regulation of molecular function;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of transcription, DNA-templated;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 4;3;5;4;4;4;2;4;6;5;6;4;5;4;3;4;5;3;7;4;4;2;3;5;4;3;1;2;5;5;5;5;6;5;6;4;4;5;4;2;4;7;7;6;5;5;5;4;5;5;4;4;5;6;6;6;2;3;5;5;5;5;6;3;5;4;4;3;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;cellular_component;intracellular organelle lumen; 2;5;4;3;4;3;2;3;3;3;2;5;3;5;2;2;1;4; GO:0001071;GO:1901363;GO:0000166;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032553;GO:0035639;GO:0043168;GO:0043167;GO:0030554;GO:0001883;GO:0001882;GO:1901265;GO:0017111;GO:0003700;GO:0032550; nucleic acid binding transcription factor activity;heterocyclic compound binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;nucleic acid binding;DNA binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside phosphate binding;nucleoside-triphosphatase activity;transcription factor activity, sequence-specific DNA binding;purine ribonucleoside binding; 2;3;4;8;5;3;4;1;2;4;5;5;5;6;3;2;3;3;6;6;5;4;5;4;3;6;5;4;4;7;3;6; K15192 IPR000330;IPR022707;IPR016024;IPR001650;IPR014001;IPR011989;IPR027417; SNF2-related, N-terminal domain;Domain of unknown function DUF3535;Armadillo-type fold;Helicase, C-terminal;Helicase superfamily 1/2, ATP-binding domain;Armadillo-like helical;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Hs17454125 3832.0 K [K] Transcription; P08697 Alpha-2-antiplasmin OS=Homo sapiens OX=9606 GN=SERPINF2 PE=1 SV=3 - [A2AP_HUMAN] 0.971 1 1.028 1.053 1.017 1.209 0.971 0.056870428 1.03539823 0.311649863 1.028 0.000848845 1.18879056 0.000316749 GO:0007599;GO:0032874;GO:0007596;GO:0051716;GO:0051496;GO:0051495;GO:0051493;GO:0051492;GO:0071604;GO:0046330;GO:0046483;GO:0042325;GO:0042327;GO:0009605;GO:0019538;GO:0010638;GO:0009892;GO:0009893;GO:0009891;GO:0035556;GO:0050789;GO:0051346;GO:0001817;GO:0006887;GO:1901360;GO:0018130;GO:0098602;GO:0098609;GO:0043410;GO:0043412;GO:0032956;GO:0002526;GO:0016070;GO:0010557;GO:0010556;GO:0048869;GO:0000165;GO:0051128;GO:0008284;GO:0050878;GO:0008283;GO:0051017;GO:0044259;GO:0044253;GO:0030038;GO:0031032;GO:0030036;GO:0022407;GO:0061041;GO:0008217;GO:0061045;GO:0007275;GO:0022409;GO:2000112;GO:0043062;GO:0006468;GO:0019219;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0010951;GO:0010955;GO:1903317;GO:0048856;GO:0006796;GO:0010757;GO:0010755;GO:0006793;GO:0048523;GO:0048522;GO:0003013;GO:0003014;GO:0007165;GO:0003018;GO:0044710;GO:0044711;GO:0045785;GO:0033043;GO:0044092;GO:2001141;GO:0010033;GO:0003081;GO:0032963;GO:0050820;GO:0010629;GO:0006807;GO:0046328;GO:0044267;GO:0009653;GO:0044260;GO:0001568;GO:0006366;GO:0050793;GO:0050790;GO:0009889;GO:0050794;GO:0051239;GO:0051234;GO:0051336;GO:0050896;GO:0010714;GO:0010712;GO:1903318;GO:0051240;GO:0032102;GO:0032103;GO:0032101;GO:0001944;GO:0031098;GO:0032964;GO:0032965;GO:0032967;GO:0044699;GO:0043408;GO:0051248;GO:0010562;GO:0051241;GO:0051246;GO:0051247;GO:0031399;GO:1903034;GO:1903035;GO:1903036;GO:0070302;GO:0070304;GO:0003044;GO:1902680;GO:0048731;GO:0070374;GO:0070372;GO:0070371;GO:0016337;GO:0043933;GO:0045935;GO:0045937;GO:0052547;GO:0052548;GO:0042221;GO:0006996;GO:0044238;GO:0044237;GO:0044236;GO:0019220;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0090066;GO:1901362;GO:0071840;GO:0009966;GO:0009967;GO:0048514;GO:0048518;GO:0048519;GO:0042127;GO:0003008;GO:0044700;GO:0016192;GO:0044707;GO:0051094;GO:0033002;GO:0033554;GO:0043149;GO:0022607;GO:0043170;GO:0097659;GO:0003072;GO:0003073;GO:0003071;GO:0045055;GO:1900046;GO:1900047;GO:1900048;GO:0035150;GO:0006810;GO:0006952;GO:0006953;GO:0006950;GO:0050817;GO:0006954;GO:0034654;GO:0010605;GO:1902531;GO:0050818;GO:0050819;GO:0046903;GO:0070613;GO:0044271;GO:0051604;GO:0080134;GO:0031401;GO:0001775;GO:0006355;GO:0006357;GO:0006351;GO:0032774;GO:0030155;GO:0030154;GO:1902533;GO:0006139;GO:0007254;GO:0050880;GO:0050886;GO:0051917;GO:0032270;GO:0006508;GO:0051918;GO:0032502;GO:0032501;GO:0032970;GO:0006725;GO:1903506;GO:0032872;GO:0016485;GO:0051252;GO:0051254;GO:0001816;GO:0002034;GO:0001819;GO:0080135;GO:0002576;GO:0031639;GO:0031638;GO:0071704;GO:0051174;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0044331;GO:0051179;GO:1902578;GO:1902589;GO:0071634;GO:0071636;GO:0080090;GO:0023014;GO:0032231;GO:0032233;GO:0010604;GO:0009611;GO:0060255;GO:0030162;GO:0001990;GO:0030168;GO:0030199;GO:0030198;GO:0030193;GO:0019438;GO:0030195;GO:0030194;GO:0032940;GO:1901576;GO:0030029;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:0051130;GO:0008015;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0042730;GO:0048659;GO:0061572;GO:0016310;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043086;GO:0044246;GO:0022610;GO:0045597;GO:0045595;GO:0045893;GO:0007010;GO:0032269;GO:0032268;GO:2000047;GO:2000049;GO:0010628;GO:0045944;GO:0045861;GO:1903508;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0090303;GO:0071822;GO:0010467;GO:0010466;GO:0010468;GO:0009987;GO:0048660;GO:0048661;GO:0051403;GO:0007155;GO:0007154;GO:0007015;GO:0044087;GO:0044085;GO:0001932;GO:0001934;GO:0044089; hemostasis;positive regulation of stress-activated MAPK cascade;blood coagulation;cellular response to stimulus;positive regulation of stress fiber assembly;positive regulation of cytoskeleton organization;regulation of cytoskeleton organization;regulation of stress fiber assembly;transforming growth factor beta production;positive regulation of JNK cascade;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to external stimulus;protein metabolic process;positive regulation of organelle organization;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;intracellular signal transduction;regulation of biological process;negative regulation of hydrolase activity;regulation of cytokine production;exocytosis;organic cyclic compound metabolic process;heterocycle biosynthetic process;single organism cell adhesion;cell-cell adhesion;positive regulation of MAPK cascade;macromolecule modification;regulation of actin cytoskeleton organization;acute inflammatory response;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;cellular developmental process;MAPK cascade;regulation of cellular component organization;positive regulation of cell proliferation;regulation of body fluid levels;cell proliferation;actin filament bundle assembly;multicellular organismal macromolecule metabolic process;positive regulation of multicellular organismal metabolic process;contractile actin filament bundle assembly;actomyosin structure organization;actin cytoskeleton organization;regulation of cell-cell adhesion;regulation of wound healing;regulation of blood pressure;negative regulation of wound healing;multicellular organism development;positive regulation of cell-cell adhesion;regulation of cellular macromolecule biosynthetic process;extracellular structure organization;protein phosphorylation;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;negative regulation of endopeptidase activity;negative regulation of protein processing;regulation of protein maturation;anatomical structure development;phosphate-containing compound metabolic process;negative regulation of plasminogen activation;regulation of plasminogen activation;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;circulatory system process;renal system process;signal transduction;vascular process in circulatory system;single-organism metabolic process;single-organism biosynthetic process;positive regulation of cell adhesion;regulation of organelle organization;negative regulation of molecular function;regulation of RNA biosynthetic process;response to organic substance;regulation of systemic arterial blood pressure by renin-angiotensin;collagen metabolic process;positive regulation of coagulation;negative regulation of gene expression;nitrogen compound metabolic process;regulation of JNK cascade;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;blood vessel development;transcription from RNA polymerase II promoter;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;response to stimulus;positive regulation of collagen metabolic process;regulation of collagen metabolic process;negative regulation of protein maturation;positive regulation of multicellular organismal process;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;stress-activated protein kinase signaling cascade;collagen biosynthetic process;regulation of collagen biosynthetic process;positive regulation of collagen biosynthetic process;single-organism process;regulation of MAPK cascade;negative regulation of protein metabolic process;positive regulation of phosphorus metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of protein modification process;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;regulation of stress-activated protein kinase signaling cascade;positive regulation of stress-activated protein kinase signaling cascade;regulation of systemic arterial blood pressure mediated by a chemical signal;positive regulation of RNA biosynthetic process;system development;positive regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;single organismal cell-cell adhesion;macromolecular complex subunit organization;positive regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;regulation of peptidase activity;regulation of endopeptidase activity;response to chemical;organelle organization;primary metabolic process;cellular metabolic process;multicellular organism metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;regulation of anatomical structure size;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;regulation of signal transduction;positive regulation of signal transduction;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;system process;single organism signaling;vesicle-mediated transport;single-multicellular organism process;positive regulation of developmental process;muscle cell proliferation;cellular response to stress;stress fiber assembly;cellular component assembly;macromolecule metabolic process;nucleic acid-templated transcription;renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure;regulation of systemic arterial blood pressure;renal system process involved in regulation of systemic arterial blood pressure;regulated exocytosis;regulation of hemostasis;negative regulation of hemostasis;positive regulation of hemostasis;regulation of tube size;transport;defense response;acute-phase response;response to stress;coagulation;inflammatory response;nucleobase-containing compound biosynthetic process;negative regulation of macromolecule metabolic process;regulation of intracellular signal transduction;regulation of coagulation;negative regulation of coagulation;secretion;regulation of protein processing;cellular nitrogen compound biosynthetic process;protein maturation;regulation of response to stress;positive regulation of protein modification process;cell activation;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;regulation of cell adhesion;cell differentiation;positive regulation of intracellular signal transduction;nucleobase-containing compound metabolic process;JNK cascade;regulation of blood vessel size;endocrine process;regulation of fibrinolysis;positive regulation of cellular protein metabolic process;proteolysis;negative regulation of fibrinolysis;developmental process;multicellular organismal process;regulation of actin filament-based process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of stress-activated MAPK cascade;protein processing;regulation of RNA metabolic process;positive regulation of RNA metabolic process;cytokine production;regulation of blood vessel size by renin-angiotensin;positive regulation of cytokine production;regulation of cellular response to stress;platelet degranulation;plasminogen activation;zymogen activation;organic substance metabolic process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell-cell adhesion mediated by cadherin;localization;single-organism localization;single-organism organelle organization;regulation of transforming growth factor beta production;positive regulation of transforming growth factor beta production;regulation of primary metabolic process;signal transduction by protein phosphorylation;regulation of actin filament bundle assembly;positive regulation of actin filament bundle assembly;positive regulation of macromolecule metabolic process;response to wounding;regulation of macromolecule metabolic process;regulation of proteolysis;regulation of systemic arterial blood pressure by hormone;platelet activation;collagen fibril organization;extracellular matrix organization;regulation of blood coagulation;aromatic compound biosynthetic process;negative regulation of blood coagulation;positive regulation of blood coagulation;secretion by cell;organic substance biosynthetic process;actin filament-based process;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;blood circulation;wound healing;protein modification process;biological_process;metabolic process;fibrinolysis;smooth muscle cell proliferation;actin filament bundle organization;phosphorylation;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;regulation of multicellular organismal metabolic process;biological adhesion;positive regulation of cell differentiation;regulation of cell differentiation;positive regulation of transcription, DNA-templated;cytoskeleton organization;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of cell-cell adhesion mediated by cadherin;positive regulation of cell-cell adhesion mediated by cadherin;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;negative regulation of proteolysis;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of wound healing;protein complex subunit organization;gene expression;negative regulation of peptidase activity;regulation of gene expression;cellular process;regulation of smooth muscle cell proliferation;positive regulation of smooth muscle cell proliferation;stress-activated MAPK cascade;cell adhesion;cell communication;actin filament organization;regulation of cellular component biogenesis;cellular component biogenesis;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular component biogenesis; 5;7;5;3;5;6;6;5;5;8;4;7;7;3;4;5;3;3;4;5;2;6;4;5;4;5;3;4;6;5;5;6;5;5;5;4;5;4;4;4;3;5;5;4;6;6;5;5;6;4;5;4;5;6;4;7;5;6;3;4;3;8;7;6;3;5;8;8;4;3;3;4;4;4;5;3;4;4;5;4;6;4;6;6;4;5;3;7;5;3;4;4;7;3;4;4;3;3;3;5;2;5;5;6;3;4;4;4;5;5;5;6;6;2;6;5;5;3;5;5;6;5;4;4;5;6;6;6;4;7;7;6;4;4;5;6;6;7;3;4;3;3;4;6;3;3;3;3;5;5;4;5;2;4;4;4;2;2;4;3;3;5;3;3;4;4;7;4;4;7;6;5;5;6;4;4;4;5;4;4;7;3;4;5;5;4;5;4;4;5;7;5;5;4;6;4;6;7;6;6;4;5;5;4;7;6;4;6;5;5;3;2;2;4;4;7;6;6;5;5;4;7;4;4;7;8;7;3;5;3;5;4;4;5;2;3;4;5;5;4;4;4;4;4;4;4;6;5;5;6;5;5;5;5;5;4;4;4;3;2;3;3;4;5;5;5;1;2;6;5;7;6;3;4;4;2;5;3;4;4;5;4;2;4;4;6;5;5;5;6;6;5;7;6;7;5;5;4;4;4;5;5;5;5;7;5;2;5;5;6;3;4;6;3;3;7;7;3; GO:0034774;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0070062;GO:0005615;GO:0016023;GO:0099503;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0072562;GO:0044433;GO:0030141;GO:0060205;GO:0031091;GO:0031093;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0005737;GO:0009986;GO:0031983;GO:0031988;GO:0005576;GO:0097708;GO:0031410;GO:0005623;GO:0005622;GO:1903561;GO:0032991;GO:0005575;GO:0005577; secretory granule lumen;intracellular part;extracellular region part;organelle part;cell part;extracellular exosome;extracellular space;cytoplasmic, membrane-bounded vesicle;secretory vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;blood microparticle;cytoplasmic vesicle part;secretory granule;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;platelet alpha granule lumen;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;cytoplasm;cell surface;vesicle lumen;membrane-bounded vesicle;extracellular region;intracellular vesicle;cytoplasmic vesicle;cell;intracellular;extracellular vesicle;macromolecular complex;cellular_component;fibrinogen complex; 5;3;2;2;2;4;3;5;6;3;3;4;3;3;4;4;5;5;6;2;3;3;2;3;4;3;4;4;3;4;5;2;4;5;2;3;3;2;1;3; GO:0098772;GO:0005488;GO:0046983;GO:0019899;GO:0004857;GO:0002020;GO:0005515;GO:0061135;GO:0061134;GO:0003674;GO:0042803;GO:0004866;GO:0004867;GO:0030234;GO:0030414;GO:0042802; molecular function regulator;binding;protein dimerization activity;enzyme binding;enzyme inhibitor activity;protease binding;protein binding;endopeptidase regulator activity;peptidase regulator activity;molecular_function;protein homodimerization activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;enzyme regulator activity;peptidase inhibitor activity;identical protein binding; 2;2;4;4;4;5;3;5;4;1;5;6;7;3;5;4; K03983 map04610; Complement and coagulation cascades; IPR023795;IPR000215;IPR023796;IPR033833; Serpin, conserved site;Serpin family;Serpin domain;Alpha2-antiplasmin; extracellular Hs11386143 992.0 V [V] Defense mechanisms; Q86UW7 Calcium-dependent secretion activator 2 OS=Homo sapiens OX=9606 GN=CADPS2 PE=1 SV=2 - [CAPS2_HUMAN] 1.037 0.874 1.201 1.127 0.932 0.969 1.186498856 0.037539558 1.209227468 0.079730583 1.374141876 0.046273844 1.039699571 0.522757659 GO:0008104;GO:0051046;GO:0051047;GO:0051049;GO:0001505;GO:0051656;GO:0051650;GO:0071840;GO:0051716;GO:0048518;GO:0097479;GO:0099504;GO:0051050;GO:0009267;GO:0045184;GO:0006836;GO:0097480;GO:0044700;GO:0031668;GO:0031669;GO:0016192;GO:0009605;GO:0031667;GO:0098916;GO:0033554;GO:0022607;GO:0032940;GO:0050789;GO:0048489;GO:0006887;GO:0016043;GO:0045055;GO:0065003;GO:0065007;GO:0065008;GO:0006810;GO:0050794;GO:0007268;GO:0006950;GO:0008150;GO:0051234;GO:0046903;GO:0016079;GO:0050896;GO:0099531;GO:0099536;GO:0099537;GO:0099643;GO:0051648;GO:0070271;GO:0051649;GO:0023052;GO:1903530;GO:1903532;GO:0044699;GO:0051640;GO:0017156;GO:0017157;GO:0071496;GO:0016082;GO:0060627;GO:0032879;GO:0016482;GO:0033036;GO:0046907;GO:0009991;GO:0045921;GO:0060341;GO:0043933;GO:0042594;GO:0034622;GO:0071822;GO:0071702;GO:0009987;GO:0006461;GO:0023061;GO:0044765;GO:0044763;GO:0007269;GO:0007267;GO:0007154;GO:0043623;GO:0051179;GO:1902578;GO:0051641;GO:0044085;GO:0015031;GO:1902582;GO:1902580;GO:0048522; protein localization;regulation of secretion;positive regulation of secretion;regulation of transport;regulation of neurotransmitter levels;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of biological process;synaptic vesicle localization;synaptic vesicle cycle;positive regulation of transport;cellular response to starvation;establishment of protein localization;neurotransmitter transport;establishment of synaptic vesicle localization;single organism signaling;cellular response to extracellular stimulus;cellular response to nutrient levels;vesicle-mediated transport;response to external stimulus;response to nutrient levels;anterograde trans-synaptic signaling;cellular response to stress;cellular component assembly;secretion by cell;regulation of biological process;synaptic vesicle transport;exocytosis;cellular component organization;regulated exocytosis;macromolecular complex assembly;biological regulation;regulation of biological quality;transport;regulation of cellular process;synaptic transmission;response to stress;biological_process;establishment of localization;secretion;synaptic vesicle exocytosis;response to stimulus;presynaptic process involved in synaptic transmission;synaptic signaling;trans-synaptic signaling;signal release from synapse;vesicle localization;protein complex biogenesis;establishment of localization in cell;signaling;regulation of secretion by cell;positive regulation of secretion by cell;single-organism process;organelle localization;calcium ion regulated exocytosis;regulation of exocytosis;cellular response to external stimulus;synaptic vesicle priming;regulation of vesicle-mediated transport;regulation of localization;cytosolic transport;macromolecule localization;intracellular transport;response to extracellular stimulus;positive regulation of exocytosis;regulation of cellular localization;macromolecular complex subunit organization;response to starvation;cellular macromolecular complex assembly;protein complex subunit organization;organic substance transport;cellular process;protein complex assembly;signal release;single-organism transport;single-organism cellular process;neurotransmitter secretion;cell-cell signaling;cell communication;cellular protein complex assembly;localization;single-organism localization;cellular localization;cellular component biogenesis;protein transport;single-organism intracellular transport;single-organism cellular localization;positive regulation of cellular process; 4;5;4;4;4;4;5;2;3;2;6;5;3;5;4;5;6;3;4;5;5;3;5;7;4;4;4;2;5;5;3;6;5;2;3;4;3;8;3;1;3;5;3;2;2;5;6;6;5;4;4;2;5;4;2;4;7;5;4;3;4;3;6;3;5;4;5;4;4;4;6;5;5;2;5;5;4;3;3;4;4;6;2;3;3;3;5;5;4;3; GO:0031974;GO:0097060;GO:0005654;GO:0031982;GO:0031981;GO:0016023;GO:0016020;GO:0031988;GO:0044433;GO:0098589;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043227;GO:0030054;GO:0097708;GO:0012506;GO:0042734;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0031410;GO:0005634;GO:0044456;GO:0044459;GO:0045211;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0071944;GO:0045202;GO:0098805;GO:0043226;GO:0097458;GO:0098794;GO:0005886;GO:0030659;GO:0005575;GO:0070013;GO:0098793; membrane-enclosed lumen;synaptic membrane;nucleoplasm;vesicle;nuclear lumen;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;cytoplasmic vesicle part;membrane region;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;membrane part;organelle part;plasma membrane region;membrane-bounded organelle;cell junction;intracellular vesicle;vesicle membrane;presynaptic membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;cytoplasmic vesicle;nucleus;synapse part;plasma membrane part;postsynaptic membrane;cell part;intracellular organelle;cell;intracellular;cell periphery;synapse;whole membrane;organelle;neuron part;postsynapse;plasma membrane;cytoplasmic vesicle membrane;cellular_component;intracellular organelle lumen;presynapse; 2;3;5;4;5;5;2;5;4;3;4;3;4;3;2;2;4;3;2;4;4;4;3;4;4;3;5;5;2;3;4;2;3;2;3;3;2;3;2;3;3;3;5;1;4;3; GO:0003674;GO:0005488;GO:0046872;GO:0043169;GO:0043167;GO:0008289; molecular_function;binding;metal ion binding;cation binding;ion binding;lipid binding; 1;2;5;4;3;3; K19933 IPR010439;IPR001849;IPR011993;IPR000008;IPR014770;IPR033227; Calcium-dependent secretion activator domain;Pleckstrin homology domain;PH domain-like;C2 domain;Munc13 homology 1;Calcium-dependent secretion activator; cytosol Hs18556531 2058.0 T [T] Signal transduction mechanisms; P25311 Zinc-alpha-2-glycoprotein OS=Homo sapiens OX=9606 GN=AZGP1 PE=1 SV=2 - [ZA2G_HUMAN] 1.05 1.009 0.968 1.069 0.984 1.057 1.040634291 0.000292564 1.086382114 3.15E-19 0.959365709 0.001202036 1.074186992 4.55E-13 GO:0008104;GO:0009593;GO:0060249;GO:0044707;GO:1901360;GO:0001580;GO:0048519;GO:0033036;GO:0042127;GO:0007606;GO:0007600;GO:0045184;GO:0003008;GO:0048871;GO:0002376;GO:0006807;GO:0048002;GO:0043170;GO:0050789;GO:0046483;GO:0065007;GO:0065008;GO:0019882;GO:0044260;GO:0006810;GO:0050794;GO:0008150;GO:0006955;GO:0051234;GO:0051606;GO:0050896;GO:0050913;GO:0008152;GO:0016070;GO:0034641;GO:0044699;GO:0006139;GO:0071806;GO:0022610;GO:0008285;GO:0032501;GO:0008283;GO:0050877;GO:0009987;GO:0006725;GO:0001894;GO:0001895;GO:0055085;GO:0042592;GO:0090501;GO:0090304;GO:0090305;GO:0050906;GO:0050907;GO:0050909;GO:0002474;GO:0071704;GO:0071702;GO:0044765;GO:0050912;GO:0044763;GO:0007155;GO:0042221;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0015031;GO:0048523; protein localization;detection of chemical stimulus;anatomical structure homeostasis;single-multicellular organism process;organic cyclic compound metabolic process;detection of chemical stimulus involved in sensory perception of bitter taste;negative regulation of biological process;macromolecule localization;regulation of cell proliferation;sensory perception of chemical stimulus;sensory perception;establishment of protein localization;system process;multicellular organismal homeostasis;immune system process;nitrogen compound metabolic process;antigen processing and presentation of peptide antigen;macromolecule metabolic process;regulation of biological process;heterocycle metabolic process;biological regulation;regulation of biological quality;antigen processing and presentation;cellular macromolecule metabolic process;transport;regulation of cellular process;biological_process;immune response;establishment of localization;detection of stimulus;response to stimulus;sensory perception of bitter taste;metabolic process;RNA metabolic process;cellular nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;protein transmembrane transport;biological adhesion;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;neurological system process;cellular process;cellular aromatic compound metabolic process;tissue homeostasis;retina homeostasis;transmembrane transport;homeostatic process;RNA phosphodiester bond hydrolysis;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception;sensory perception of taste;antigen processing and presentation of peptide antigen via MHC class I;organic substance metabolic process;organic substance transport;single-organism transport;detection of chemical stimulus involved in sensory perception of taste;single-organism cellular process;cell adhesion;response to chemical;localization;single-organism localization;primary metabolic process;cellular metabolic process;protein transport;negative regulation of cellular process; 4;4;5;3;4;7;2;3;4;6;5;4;3;4;2;3;4;4;2;4;2;3;3;4;4;3;1;3;3;3;2;8;2;5;4;2;4;5;2;4;2;3;4;2;4;5;6;4;4;6;5;6;4;5;7;5;3;5;4;6;3;3;3;2;3;3;3;5;3; GO:0031982;GO:0016020;GO:0043234;GO:0042611;GO:0042612;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0043229;GO:0043227;GO:0005634;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0098797;GO:0098796;GO:0005576; vesicle;membrane;protein complex;MHC protein complex;MHC class I protein complex;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;intracellular organelle;membrane-bounded organelle;nucleus;plasma membrane part;cell part;cell;intracellular;cell periphery;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;plasma membrane protein complex;membrane protein complex;extracellular region; 4;2;3;5;6;3;4;3;2;2;3;3;5;3;2;2;3;3;4;2;3;3;3;2;1;4;3;2; GO:0042605;GO:0097367;GO:0033218;GO:0003674;GO:0005488;GO:0008565;GO:0022884;GO:0004540;GO:0016787;GO:0016788;GO:0003824;GO:0003823;GO:0042277;GO:0022891;GO:0022892;GO:0001948;GO:0008320;GO:0004518;GO:0005515;GO:0005215;GO:0022857; peptide antigen binding;carbohydrate derivative binding;amide binding;molecular_function;binding;protein transporter activity;macromolecule transmembrane transporter activity;ribonuclease activity;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;antigen binding;peptide binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;glycoprotein binding;protein transmembrane transporter activity;nuclease activity;protein binding;transporter activity;transmembrane transporter activity; 4;3;3;1;2;4;5;6;3;4;2;3;4;4;3;4;5;5;3;2;3; IPR007110;IPR013783;IPR001039;IPR003597;IPR003006;IPR011162;IPR011161; Immunoglobulin-like domain;Immunoglobulin-like fold;MHC class I alpha chain, alpha1 alpha2 domains;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site;MHC classes I/II-like antigen recognition protein;MHC class I-like antigen recognition-like; extracellular Q9H694 Protein bicaudal C homolog 1 OS=Homo sapiens OX=9606 GN=BICC1 PE=1 SV=2 - [BICC1_HUMAN] 0.993 1.369 0.608 1.295 1.208 0.554 0.725346969 nan 1.072019868 nan 0.444119795 nan 0.458609272 nan GO:0090090;GO:0016055;GO:0007166;GO:0050789;GO:0048585;GO:0048583;GO:0023057;GO:0072359;GO:0072358;GO:0023051;GO:0009799;GO:0048523;GO:0010646;GO:0007275;GO:0044699;GO:0007389;GO:0051716;GO:0009968;GO:0009966;GO:0007368;GO:0048513;GO:0065007;GO:0048519;GO:0032502;GO:0032501;GO:0030178;GO:0044700;GO:0009987;GO:0050794;GO:0044767;GO:0060070;GO:0008150;GO:0023052;GO:0007154;GO:0007507;GO:0044707;GO:0050896;GO:0048856;GO:0030111;GO:0044763;GO:0010648;GO:0009855;GO:0048731;GO:0060828;GO:0007165; negative regulation of canonical Wnt signaling pathway;Wnt signaling pathway;cell surface receptor signaling pathway;regulation of biological process;negative regulation of response to stimulus;regulation of response to stimulus;negative regulation of signaling;circulatory system development;cardiovascular system development;regulation of signaling;specification of symmetry;negative regulation of cellular process;regulation of cell communication;multicellular organism development;single-organism process;pattern specification process;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;determination of left/right symmetry;animal organ development;biological regulation;negative regulation of biological process;developmental process;multicellular organismal process;negative regulation of Wnt signaling pathway;single organism signaling;cellular process;regulation of cellular process;single-organism developmental process;canonical Wnt signaling pathway;biological_process;signaling;cell communication;heart development;single-multicellular organism process;response to stimulus;anatomical structure development;regulation of Wnt signaling pathway;single-organism cellular process;negative regulation of cell communication;determination of bilateral symmetry;system development;regulation of canonical Wnt signaling pathway;signal transduction; 6;6;5;2;3;3;3;5;5;3;5;3;4;4;2;4;3;4;4;7;4;2;2;2;2;5;3;2;3;3;7;1;2;4;4;3;2;3;5;3;4;6;4;6;4; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0044822;GO:0097159;GO:0003723; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;poly(A) RNA binding;organic cyclic compound binding;RNA binding; 1;2;4;3;6;3;5; K18756 IPR004087;IPR013761;IPR001660;IPR004088; K Homology domain;Sterile alpha motif/pointed domain;Sterile alpha motif domain;K Homology domain, type 1; nucleus Q8TE73 Dynein heavy chain 5, axonemal OS=Homo sapiens OX=9606 GN=DNAH5 PE=1 SV=3 - [DYH5_HUMAN] 0.701 0.588 2.162 0.807 0.656 1.029 1.192176871 nan 1.230182927 nan 3.676870748 nan 1.568597561 nan GO:0072359;GO:0060322;GO:0003341;GO:0071840;GO:0021591;GO:0048869;GO:0007368;GO:0048513;GO:0044707;GO:0048870;GO:0072358;GO:0044782;GO:0021537;GO:0022607;GO:0006928;GO:0000226;GO:0000902;GO:0035082;GO:0016043;GO:0065003;GO:0048646;GO:0042384;GO:0060271;GO:0008150;GO:0007420;GO:0001578;GO:0070271;GO:0010927;GO:0009799;GO:0009653;GO:0044699;GO:0007417;GO:0070286;GO:0043933;GO:0032502;GO:0040011;GO:0032501;GO:0030317;GO:0009987;GO:0007010;GO:0021670;GO:0048858;GO:0051674;GO:0048731;GO:0030030;GO:0030031;GO:0034622;GO:0007275;GO:0007389;GO:0071822;GO:0032989;GO:0006461;GO:0044767;GO:0044763;GO:0070925;GO:0043623;GO:0051179;GO:0006996;GO:0007507;GO:0007017;GO:0032990;GO:0007399;GO:0048856;GO:0007018;GO:0036158;GO:1902589;GO:0044085;GO:0030900;GO:0009855; circulatory system development;head development;cilium movement;cellular component organization or biogenesis;ventricular system development;cellular developmental process;determination of left/right symmetry;animal organ development;single-multicellular organism process;cell motility;cardiovascular system development;cilium organization;telencephalon development;cellular component assembly;movement of cell or subcellular component;microtubule cytoskeleton organization;cell morphogenesis;axoneme assembly;cellular component organization;macromolecular complex assembly;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;biological_process;brain development;microtubule bundle formation;protein complex biogenesis;cellular component assembly involved in morphogenesis;specification of symmetry;anatomical structure morphogenesis;single-organism process;central nervous system development;axonemal dynein complex assembly;macromolecular complex subunit organization;developmental process;locomotion;multicellular organismal process;sperm motility;cellular process;cytoskeleton organization;lateral ventricle development;cell projection morphogenesis;localization of cell;system development;cell projection organization;cell projection assembly;cellular macromolecular complex assembly;multicellular organism development;pattern specification process;protein complex subunit organization;cellular component morphogenesis;protein complex assembly;single-organism developmental process;single-organism cellular process;organelle assembly;cellular protein complex assembly;localization;organelle organization;heart development;microtubule-based process;cell part morphogenesis;nervous system development;anatomical structure development;microtubule-based movement;outer dynein arm assembly;single-organism organelle organization;cellular component biogenesis;forebrain development;determination of bilateral symmetry; 5;4;6;2;5;4;7;4;3;3;5;5;4;4;4;5;5;5;3;5;3;5;6;1;4;6;4;4;5;3;2;5;5;4;2;2;2;4;2;5;4;5;3;4;4;5;6;4;4;5;4;5;3;3;5;6;2;4;4;4;5;5;3;5;6;4;3;4;6; GO:0099512;GO:0099513;GO:0005858;GO:1902494;GO:0042995;GO:0043234;GO:0043232;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0030286;GO:0043226;GO:0005856;GO:0044430;GO:0005930;GO:0044446;GO:0044447;GO:0097014;GO:0044441;GO:0005874;GO:0005875;GO:0005737;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0015630;GO:0036157;GO:0032991;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;axonemal dynein complex;catalytic complex;cell projection;protein complex;intracellular non-membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;dynein complex;organelle;cytoskeleton;cytoskeletal part;axoneme;intracellular organelle part;axoneme part;ciliary plasm;ciliary part;microtubule;microtubule associated complex;cytoplasm;cell projection part;cell part;cell;intracellular;microtubule cytoskeleton;outer dynein arm;macromolecular complex;cellular_component; 2;3;5;4;3;3;4;3;2;3;3;3;5;2;5;4;4;3;4;4;3;4;4;4;3;2;2;3;6;6;2;1; GO:1901363;GO:0000166;GO:0016818;GO:0097367;GO:0016817;GO:0003777;GO:0005488;GO:0016887;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0016787;GO:0003824;GO:0036094;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0005524;GO:0043167;GO:0030554;GO:0097159;GO:0003674;GO:0001883;GO:0001882;GO:0016462;GO:0017111;GO:0043168; heterocyclic compound binding;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;microtubule motor activity;binding;ATPase activity;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;hydrolase activity;catalytic activity;small molecule binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ATP binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;molecular_function;purine nucleoside binding;nucleoside binding;pyrophosphatase activity;nucleoside-triphosphatase activity;anion binding; 3;4;5;3;4;9;2;8;4;5;5;8;3;2;3;6;5;6;4;5;6;3;6;3;1;5;4;6;7;4; K10408 map05016; Huntington's disease; IPR011704;IPR003593;IPR035699;IPR013594;IPR013602;IPR024743;IPR004273;IPR035706;IPR026983;IPR027417;IPR024317; ATPase, dynein-related, AAA domain;AAA+ ATPase domain;Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1;Dynein heavy chain, domain-1;Dynein heavy chain, domain-2;Dynein heavy chain, coiled coil stalk;Dynein heavy chain domain;Dynein heavy chain, ATP-binding dynein motor region D5;Dynein heavy chain;P-loop containing nucleoside triphosphate hydrolase;Dynein heavy chain, AAA module D4; mitochondria Hs19115954 9606.0 Z [Z] Cytoskeleton; Q99062 Granulocyte colony-stimulating factor receptor OS=Homo sapiens OX=9606 GN=CSF3R PE=1 SV=1 - [CSF3R_HUMAN] 0.967 0.935 1.026 1.005 1.008 1.863 1.034224599 nan 0.99702381 nan 1.097326203 nan 1.848214286 nan GO:0048856;GO:0051239;GO:1990266;GO:0009887;GO:0006928;GO:0050900;GO:0051674;GO:0023052;GO:0007165;GO:0070887;GO:0060326;GO:0009653;GO:0007275;GO:0044699;GO:0097186;GO:0051716;GO:0042330;GO:0048869;GO:0050789;GO:0048513;GO:0065007;GO:0097530;GO:0002682;GO:0048534;GO:0016477;GO:0048646;GO:0032502;GO:0030595;GO:0032501;GO:0030593;GO:0006935;GO:0050793;GO:0009987;GO:0006952;GO:0050794;GO:0044767;GO:0006950;GO:0044763;GO:0048731;GO:0007155;GO:0042221;GO:1903706;GO:0051179;GO:0002520;GO:0040011;GO:0044700;GO:0071621;GO:0042475;GO:0044707;GO:0009605;GO:0048870;GO:0022610;GO:0050896;GO:0042476;GO:0045595;GO:0030097;GO:0002376;GO:0007154;GO:2000026;GO:0030099;GO:0030154;GO:0008150;GO:0097529;GO:0045637; anatomical structure development;regulation of multicellular organismal process;neutrophil migration;organ morphogenesis;movement of cell or subcellular component;leukocyte migration;localization of cell;signaling;signal transduction;cellular response to chemical stimulus;cell chemotaxis;anatomical structure morphogenesis;multicellular organism development;single-organism process;amelogenesis;cellular response to stimulus;taxis;cellular developmental process;regulation of biological process;animal organ development;biological regulation;granulocyte migration;regulation of immune system process;hematopoietic or lymphoid organ development;cell migration;anatomical structure formation involved in morphogenesis;developmental process;leukocyte chemotaxis;multicellular organismal process;neutrophil chemotaxis;chemotaxis;regulation of developmental process;cellular process;defense response;regulation of cellular process;single-organism developmental process;response to stress;single-organism cellular process;system development;cell adhesion;response to chemical;regulation of hemopoiesis;localization;immune system development;locomotion;single organism signaling;granulocyte chemotaxis;odontogenesis of dentin-containing tooth;single-multicellular organism process;response to external stimulus;cell motility;biological adhesion;response to stimulus;odontogenesis;regulation of cell differentiation;hemopoiesis;immune system process;cell communication;regulation of multicellular organismal development;myeloid cell differentiation;cell differentiation;biological_process;myeloid leukocyte migration;regulation of myeloid cell differentiation; 3;3;6;4;4;3;3;2;4;4;5;3;4;2;4;3;3;4;2;4;2;5;3;4;4;3;2;4;2;6;4;3;2;4;3;3;3;3;4;3;3;4;2;3;2;3;5;6;3;3;3;2;2;5;4;5;2;4;4;6;5;1;4;5; GO:0031226;GO:0005575;GO:0016021;GO:0016020;GO:0031224;GO:0044425;GO:0044459;GO:0005887;GO:0005886;GO:0071944;GO:0044464;GO:0005623;GO:0005576; intrinsic component of plasma membrane;cellular_component;integral component of membrane;membrane;intrinsic component of membrane;membrane part;plasma membrane part;integral component of plasma membrane;plasma membrane;cell periphery;cell part;cell;extracellular region; 4;1;4;2;3;2;3;4;3;3;2;2;2; GO:0003674;GO:0038023;GO:0004871;GO:0060089;GO:0004888;GO:0004896;GO:0099600;GO:0004872; molecular_function;signaling receptor activity;signal transducer activity;molecular transducer activity;transmembrane signaling receptor activity;cytokine receptor activity;transmembrane receptor activity;receptor activity; 1;3;2;2;4;5;4;3; K05061 map04060;map04151;map04630;map04640;map05200; Cytokine-cytokine receptor interaction;PI3K-Akt signaling pathway;Jak-STAT signaling pathway;Hematopoietic cell lineage;Pathways in cancer; IPR003529;IPR003961;IPR013783;IPR010457;IPR007110; Long hematopoietin receptor, Gp130 family 2, conserved site;Fibronectin type III;Immunoglobulin-like fold;Immunoglobulin C2-set-like, ligand-binding;Immunoglobulin-like domain; plasma membrane P22681 E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2 - [CBL_HUMAN] 1.088 1.209 0.77 0.854 1.312 0.929 0.899917287 nan 0.650914634 nan 0.636889992 nan 0.708079268 nan GO:0080090;GO:0019222;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0014065;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0048260;GO:1901362;GO:0071840;GO:0051716;GO:0014066;GO:0009968;GO:0009966;GO:0009967;GO:0070647;GO:0070848;GO:0032446;GO:0048518;GO:0048519;GO:0051050;GO:0060255;GO:0060548;GO:0007178;GO:0007173;GO:2001141;GO:0071559;GO:0010033;GO:0007179;GO:0010467;GO:0044700;GO:0016192;GO:0044249;GO:0019538;GO:0030163;GO:0016567;GO:0007154;GO:0019438;GO:0009056;GO:0034645;GO:0010647;GO:0006807;GO:1901184;GO:1901185;GO:0050789;GO:0097659;GO:1901576;GO:1901575;GO:0044265;GO:0046483;GO:0044344;GO:0016043;GO:0065007;GO:1901360;GO:0009057;GO:0035556;GO:0018130;GO:0051130;GO:0043067;GO:0006139;GO:0006810;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:1902533;GO:0048259;GO:0051234;GO:0048017;GO:0016070;GO:0051603;GO:0006897;GO:0012501;GO:0050896;GO:0006898;GO:0006355;GO:0010556;GO:0006351;GO:0071774;GO:0006511;GO:0032774;GO:0051128;GO:0023057;GO:0034641;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0010646;GO:0008543;GO:0044699;GO:0009719;GO:1902531;GO:0006508;GO:0071495;GO:0043170;GO:0023056;GO:0009987;GO:0006725;GO:1903506;GO:0060627;GO:0014068;GO:0044257;GO:0044271;GO:0032879;GO:0071363;GO:0051252;GO:0071560;GO:0031326;GO:0031323;GO:0042059;GO:0042058;GO:0090304;GO:0008219;GO:0010941;GO:0043632;GO:0042981;GO:2000112;GO:0071704;GO:0071310;GO:0043066;GO:0042787;GO:0043069;GO:0010468;GO:0048015;GO:0044267;GO:0019219;GO:0019941;GO:0006915;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0042221;GO:0030100;GO:0051179;GO:0044248;GO:0044238;GO:0044260;GO:0044237;GO:0010648;GO:0045807;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;phosphatidylinositol 3-kinase signaling;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of receptor-mediated endocytosis;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;regulation of phosphatidylinositol 3-kinase signaling;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;protein modification by small protein conjugation or removal;response to growth factor;protein modification by small protein conjugation;positive regulation of biological process;negative regulation of biological process;positive regulation of transport;regulation of macromolecule metabolic process;negative regulation of cell death;transmembrane receptor protein serine/threonine kinase signaling pathway;epidermal growth factor receptor signaling pathway;regulation of RNA biosynthetic process;response to transforming growth factor beta;response to organic substance;transforming growth factor beta receptor signaling pathway;gene expression;single organism signaling;vesicle-mediated transport;cellular biosynthetic process;protein metabolic process;protein catabolic process;protein ubiquitination;cell communication;aromatic compound biosynthetic process;catabolic process;cellular macromolecule biosynthetic process;positive regulation of cell communication;nitrogen compound metabolic process;regulation of ERBB signaling pathway;negative regulation of ERBB signaling pathway;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule catabolic process;heterocycle metabolic process;cellular response to fibroblast growth factor stimulus;cellular component organization;biological regulation;organic cyclic compound metabolic process;macromolecule catabolic process;intracellular signal transduction;heterocycle biosynthetic process;positive regulation of cellular component organization;regulation of programmed cell death;nucleobase-containing compound metabolic process;transport;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of receptor-mediated endocytosis;establishment of localization;inositol lipid-mediated signaling;RNA metabolic process;proteolysis involved in cellular protein catabolic process;endocytosis;programmed cell death;response to stimulus;receptor-mediated endocytosis;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;response to fibroblast growth factor;ubiquitin-dependent protein catabolic process;RNA biosynthetic process;regulation of cellular component organization;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;fibroblast growth factor receptor signaling pathway;single-organism process;response to endogenous stimulus;regulation of intracellular signal transduction;proteolysis;cellular response to endogenous stimulus;macromolecule metabolic process;positive regulation of signaling;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of vesicle-mediated transport;positive regulation of phosphatidylinositol 3-kinase signaling;cellular protein catabolic process;cellular nitrogen compound biosynthetic process;regulation of localization;cellular response to growth factor stimulus;regulation of RNA metabolic process;cellular response to transforming growth factor beta stimulus;regulation of cellular biosynthetic process;regulation of cellular metabolic process;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;nucleic acid metabolic process;cell death;regulation of cell death;modification-dependent macromolecule catabolic process;regulation of apoptotic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;negative regulation of apoptotic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;negative regulation of programmed cell death;regulation of gene expression;phosphatidylinositol-mediated signaling;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;modification-dependent protein catabolic process;apoptotic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;response to chemical;regulation of endocytosis;localization;cellular catabolic process;primary metabolic process;cellular macromolecule metabolic process;cellular metabolic process;negative regulation of cell communication;positive regulation of endocytosis;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;3;3;3;8;4;5;6;7;5;5;2;3;6;4;4;4;7;5;8;2;2;3;4;4;7;9;6;4;4;6;5;3;5;4;4;5;9;4;5;3;5;4;3;5;5;2;7;4;4;5;4;5;3;2;4;5;5;5;4;5;4;4;4;3;5;5;1;2;5;5;6;3;6;5;6;6;5;2;7;6;5;6;4;8;6;4;3;4;2;8;4;3;4;6;2;3;5;5;4;4;3;2;4;7;4;6;6;5;3;6;5;5;5;4;6;6;5;4;4;6;6;6;3;5;6;9;5;5;7;5;5;7;6;6;3;5;3;4;3;5;2;4;3;4;3;4;4;3;3; GO:0016020;GO:0005829;GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005737;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0044444;GO:0005886;GO:0005575; membrane;cytosol;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;cytoplasm;organelle;nucleus;cell part;cell;intracellular;cell periphery;cytoplasmic part;plasma membrane;cellular_component; 2;5;4;3;3;3;4;2;5;2;2;3;3;4;3;1; GO:0016740;GO:0046872;GO:0046875;GO:0019904;GO:0008270;GO:0003674;GO:0005488;GO:0046914;GO:0003824;GO:0004842;GO:0016874;GO:0061659;GO:0043169;GO:0061630;GO:0043167;GO:0005509;GO:0001071;GO:0005515;GO:0005102;GO:0017124;GO:0004871;GO:0019787;GO:0003700; transferase activity;metal ion binding;ephrin receptor binding;protein domain specific binding;zinc ion binding;molecular_function;binding;transition metal ion binding;catalytic activity;ubiquitin-protein transferase activity;ligase activity;ubiquitin-like protein ligase activity;cation binding;ubiquitin protein ligase activity;ion binding;calcium ion binding;nucleic acid binding transcription factor activity;protein binding;receptor binding;SH3 domain binding;signal transducer activity;ubiquitin-like protein transferase activity;transcription factor activity, sequence-specific DNA binding; 3;5;5;4;7;1;2;6;2;5;3;5;4;6;3;6;2;3;4;5;2;4;3; K04707 map04012;map04120;map04144;map04660;map04910;map05100;map05200;map05205;map05220; ErbB signaling pathway;Ubiquitin mediated proteolysis;Endocytosis;T cell receptor signaling pathway;Insulin signaling pathway;Bacterial invasion of epithelial cells;Pathways in cancer;Proteoglycans in cancer;Chronic myeloid leukemia; IPR009060;IPR001841;IPR000980;IPR015940;IPR013083;IPR024159;IPR011992;IPR014741;IPR014742;IPR003153;IPR017907;IPR024162; UBA-like;Zinc finger, RING-type;SH2 domain;Ubiquitin-associated domain;Zinc finger, RING/FYVE/PHD-type;Adaptor protein Cbl, PTB domain;EF-hand domain pair;Adaptor protein Cbl, EF hand-like;Adaptor protein Cbl, SH2-like domain;Adaptor protein Cbl, N-terminal helical;Zinc finger, RING-type, conserved site;Adaptor protein Cbl; nucleus Hs4885117 1872.0 V [V] Defense mechanisms; Q9BX84 Transient receptor potential cation channel subfamily M member 6 OS=Homo sapiens OX=9606 GN=TRPM6 PE=1 SV=2 - [TRPM6_HUMAN] 0.885 1.098 1.12 0.964 1.01 0.981 0.806010929 0.3939298 0.954455446 0.814896323 1.02003643 0.859332991 0.971287129 0.979345879 GO:0071840;GO:0098662;GO:0070838;GO:0070588;GO:0022607;GO:0016043;GO:0065003;GO:0044699;GO:0098660;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:0008150;GO:0051234;GO:0050896;GO:0070271;GO:0030001;GO:0055085;GO:0051259;GO:0072511;GO:0043933;GO:0071822;GO:0009636;GO:0051262;GO:0009987;GO:0006461;GO:0034220;GO:0044765;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0044085;GO:0098655; cellular component organization or biogenesis;inorganic cation transmembrane transport;divalent metal ion transport;calcium ion transmembrane transport;cellular component assembly;cellular component organization;macromolecular complex assembly;single-organism process;inorganic ion transmembrane transport;cation transport;ion transport;transport;calcium ion transport;biological_process;establishment of localization;response to stimulus;protein complex biogenesis;metal ion transport;transmembrane transport;protein oligomerization;divalent inorganic cation transport;macromolecular complex subunit organization;protein complex subunit organization;response to toxic substance;protein tetramerization;cellular process;protein complex assembly;ion transmembrane transport;single-organism transport;single-organism cellular process;response to chemical;localization;single-organism localization;cellular component biogenesis;cation transmembrane transport; 2;7;8;8;4;3;5;2;6;6;5;4;9;1;3;2;4;7;4;6;7;4;5;4;7;2;5;5;4;3;3;2;3;3;6; GO:0016021;GO:0016020;GO:0098589;GO:0042995;GO:0044425;GO:0098590;GO:0031253;GO:0005903;GO:0031224;GO:0045177;GO:0044459;GO:0016324;GO:0098862;GO:0044463;GO:0044464;GO:0005623;GO:0071944;GO:0098805;GO:0005886;GO:0031526;GO:0005575; integral component of membrane;membrane;membrane region;cell projection;membrane part;plasma membrane region;cell projection membrane;brush border;intrinsic component of membrane;apical part of cell;plasma membrane part;apical plasma membrane;cluster of actin-based cell projections;cell projection part;cell part;cell;cell periphery;whole membrane;plasma membrane;brush border membrane;cellular_component; 4;2;3;3;2;4;4;4;3;3;3;4;3;3;2;2;3;3;3;5;1; GO:0005261;GO:0005262;GO:1901363;GO:0015085;GO:0000166;GO:0016740;GO:0046873;GO:0046872;GO:0017076;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0022803;GO:0005524;GO:0016301;GO:0003824;GO:0022891;GO:0022890;GO:0022892;GO:0016773;GO:0016772;GO:0015075;GO:0015267;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0043168;GO:0043169;GO:0032549;GO:0072509;GO:0005215;GO:0005216;GO:0008324;GO:0030554;GO:0097159;GO:0022838;GO:0001883;GO:0001882;GO:0004674;GO:0004672;GO:0036094;GO:0022857; cation channel activity;calcium channel activity;heterocyclic compound binding;calcium ion transmembrane transporter activity;nucleotide binding;transferase activity;metal ion transmembrane transporter activity;metal ion binding;purine nucleotide binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;passive transmembrane transporter activity;ATP binding;kinase activity;catalytic activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;ion transmembrane transporter activity;channel activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;anion binding;cation binding;ribonucleoside binding;divalent inorganic cation transmembrane transporter activity;transporter activity;ion channel activity;cation transmembrane transporter activity;adenyl nucleotide binding;organic cyclic compound binding;substrate-specific channel activity;purine nucleoside binding;nucleoside binding;protein serine/threonine kinase activity;protein kinase activity;small molecule binding;transmembrane transporter activity; 7;8;3;9;4;3;8;5;5;3;1;2;4;4;6;5;2;4;7;3;5;4;5;5;6;5;6;4;5;3;4;4;5;8;2;6;6;6;3;5;5;4;7;6;3;3; K04981 map04978; Mineral absorption; IPR032415;IPR005821;IPR004166;IPR011009;IPR029597; TRPM, tetramerisation domain;Ion transport domain;MHCK/EF2 kinase;Protein kinase-like domain;Transient receptor potential cation channel subfamily M member 6; plasma membrane Hs18921093 4228.0 PT [P] Inorganic ion transport and metabolism;[T] Signal transduction mechanisms; Q99996 A-kinase anchor protein 9 OS=Homo sapiens OX=9606 GN=AKAP9 PE=1 SV=4 - [AKAP9_HUMAN] 1.083 0.938 0.798 0.831 1.139 1.942 1.154584222 0.327087674 0.729587357 0.018638501 0.850746269 0.289726249 1.70500439 0.000601944 GO:0019220;GO:0080090;GO:0019222;GO:0000086;GO:0051049;GO:0048584;GO:0048583;GO:0032147;GO:0003013;GO:0007165;GO:0007166;GO:0007167;GO:0030182;GO:0034765;GO:0032989;GO:0023014;GO:0051716;GO:0010604;GO:0042330;GO:0009966;GO:0009967;GO:0071840;GO:0000165;GO:0070848;GO:0018193;GO:0014070;GO:0010959;GO:0044093;GO:0048518;GO:0002682;GO:0032409;GO:0098662;GO:0006935;GO:0051050;GO:0060255;GO:0048468;GO:0045859;GO:0006952;GO:0031109;GO:0042221;GO:0050776;GO:1901379;GO:0043434;GO:0097485;GO:0010033;GO:0042325;GO:0044700;GO:0042327;GO:0018209;GO:0009605;GO:0044707;GO:0019538;GO:0010243;GO:0071320;GO:0046683;GO:0032868;GO:0098916;GO:0071407;GO:0002768;GO:0003015;GO:0032414;GO:0042391;GO:0022607;GO:0009893;GO:0032412;GO:0033674;GO:1904062;GO:0060307;GO:0060306;GO:0006928;GO:0034764;GO:0031175;GO:0035556;GO:0071900;GO:0050789;GO:0044267;GO:0009653;GO:0051347;GO:0000902;GO:0044260;GO:0043549;GO:0044344;GO:0016043;GO:0098655;GO:0065003;GO:0008015;GO:0065007;GO:0044699;GO:0098660;GO:0065009;GO:0065008;GO:1901700;GO:0006810;GO:0061564;GO:0008016;GO:0006813;GO:0006812;GO:0006811;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0048011;GO:1902533;GO:1902531;GO:0002027;GO:0044767;GO:0038095;GO:0044057;GO:0022898;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0099622;GO:0099623;GO:0099625;GO:0048869;GO:0071774;GO:1903522;GO:0099536;GO:0099537;GO:0032411;GO:0051239;GO:0035637;GO:0070271;GO:0016310;GO:0030154;GO:0086091;GO:0086009;GO:0023056;GO:0043405;GO:0060047;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0007411;GO:0010647;GO:0010646;GO:0008543;GO:0007265;GO:0043085;GO:0043408;GO:0009719;GO:0051234;GO:0071375;GO:0071804;GO:0071805;GO:0010562;GO:0051246;GO:0051247;GO:0003008;GO:0043933;GO:0046785;GO:0007268;GO:0032270;GO:0031399;GO:0015672;GO:0032502;GO:0006996;GO:0008286;GO:0032501;GO:1901018;GO:1901701;GO:0009987;GO:0043270;GO:0032870;GO:0030001;GO:0007409;GO:0048010;GO:0032879;GO:0061337;GO:0055085;GO:0048858;GO:0051258;GO:0007049;GO:0032268;GO:0071363;GO:0009725;GO:1904064;GO:0007169;GO:0043170;GO:1901699;GO:0048731;GO:0034762;GO:0045860;GO:1901698;GO:0000186;GO:0018105;GO:0033138;GO:0044839;GO:0030030;GO:0033135;GO:0031325;GO:0031323;GO:1903047;GO:0051591;GO:0044770;GO:0043266;GO:0044772;GO:0022402;GO:1901016;GO:0034622;GO:0032869;GO:0014074;GO:0007275;GO:0043269;GO:0043268;GO:0038093;GO:0071822;GO:0034767;GO:0071417;GO:1902589;GO:0071704;GO:0071310;GO:0048812;GO:0038179;GO:1901381;GO:0048666;GO:0048667;GO:0006468;GO:0000278;GO:0045937;GO:0007020;GO:0045087;GO:0006461;GO:0006464;GO:0051174;GO:0034220;GO:0044765;GO:0000904;GO:0044763;GO:0007267;GO:0007154;GO:0022008;GO:0007264;GO:0043623;GO:0051179;GO:1902578;GO:0002764;GO:0040011;GO:0044238;GO:0048699;GO:0007017;GO:0007010;GO:0032990;GO:0007399;GO:0002376;GO:0048856;GO:0044237;GO:0071495;GO:0006796;GO:0044085;GO:1901652;GO:1901653;GO:0006793;GO:0007173;GO:0001932;GO:0001934;GO:0000226;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;G2/M transition of mitotic cell cycle;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;circulatory system process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;neuron differentiation;regulation of ion transmembrane transport;cellular component morphogenesis;signal transduction by protein phosphorylation;cellular response to stimulus;positive regulation of macromolecule metabolic process;taxis;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;response to growth factor;peptidyl-amino acid modification;response to organic cyclic compound;regulation of metal ion transport;positive regulation of molecular function;positive regulation of biological process;regulation of immune system process;regulation of transporter activity;inorganic cation transmembrane transport;chemotaxis;positive regulation of transport;regulation of macromolecule metabolic process;cell development;regulation of protein kinase activity;defense response;microtubule polymerization or depolymerization;response to chemical;regulation of immune response;regulation of potassium ion transmembrane transport;response to peptide hormone;neuron projection guidance;response to organic substance;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;peptidyl-serine modification;response to external stimulus;single-multicellular organism process;protein metabolic process;response to organonitrogen compound;cellular response to cAMP;response to organophosphorus;response to insulin;anterograde trans-synaptic signaling;cellular response to organic cyclic compound;immune response-regulating cell surface receptor signaling pathway;heart process;positive regulation of ion transmembrane transporter activity;regulation of membrane potential;cellular component assembly;positive regulation of metabolic process;regulation of ion transmembrane transporter activity;positive regulation of kinase activity;regulation of cation transmembrane transport;regulation of ventricular cardiac muscle cell membrane repolarization;regulation of membrane repolarization;movement of cell or subcellular component;positive regulation of transmembrane transport;neuron projection development;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cell morphogenesis;cellular macromolecule metabolic process;regulation of kinase activity;cellular response to fibroblast growth factor stimulus;cellular component organization;cation transmembrane transport;macromolecular complex assembly;blood circulation;biological regulation;single-organism process;inorganic ion transmembrane transport;regulation of molecular function;regulation of biological quality;response to oxygen-containing compound;transport;axon development;regulation of heart contraction;potassium ion transport;cation transport;ion transport;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of heart rate;single-organism developmental process;Fc-epsilon receptor signaling pathway;regulation of system process;regulation of transmembrane transporter activity;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;cardiac muscle cell membrane repolarization;regulation of cardiac muscle cell membrane repolarization;ventricular cardiac muscle cell membrane repolarization;cellular developmental process;response to fibroblast growth factor;regulation of blood circulation;synaptic signaling;trans-synaptic signaling;positive regulation of transporter activity;regulation of multicellular organismal process;multicellular organismal signaling;protein complex biogenesis;phosphorylation;cell differentiation;regulation of heart rate by cardiac conduction;membrane repolarization;positive regulation of signaling;regulation of MAP kinase activity;heart contraction;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;axon guidance;positive regulation of cell communication;regulation of cell communication;fibroblast growth factor receptor signaling pathway;Ras protein signal transduction;positive regulation of catalytic activity;regulation of MAPK cascade;response to endogenous stimulus;establishment of localization;cellular response to peptide hormone stimulus;cellular potassium ion transport;potassium ion transmembrane transport;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;system process;macromolecular complex subunit organization;microtubule polymerization;synaptic transmission;positive regulation of cellular protein metabolic process;regulation of protein modification process;monovalent inorganic cation transport;developmental process;organelle organization;insulin receptor signaling pathway;multicellular organismal process;positive regulation of potassium ion transmembrane transporter activity;cellular response to oxygen-containing compound;cellular process;positive regulation of ion transport;cellular response to hormone stimulus;metal ion transport;axonogenesis;vascular endothelial growth factor receptor signaling pathway;regulation of localization;cardiac conduction;transmembrane transport;cell projection morphogenesis;protein polymerization;cell cycle;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;response to hormone;positive regulation of cation transmembrane transport;transmembrane receptor protein tyrosine kinase signaling pathway;macromolecule metabolic process;cellular response to nitrogen compound;system development;regulation of transmembrane transport;positive regulation of protein kinase activity;response to nitrogen compound;activation of MAPKK activity;peptidyl-serine phosphorylation;positive regulation of peptidyl-serine phosphorylation;cell cycle G2/M phase transition;cell projection organization;regulation of peptidyl-serine phosphorylation;positive regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;response to cAMP;cell cycle phase transition;regulation of potassium ion transport;mitotic cell cycle phase transition;cell cycle process;regulation of potassium ion transmembrane transporter activity;cellular macromolecular complex assembly;cellular response to insulin stimulus;response to purine-containing compound;multicellular organism development;regulation of ion transport;positive regulation of potassium ion transport;Fc receptor signaling pathway;protein complex subunit organization;positive regulation of ion transmembrane transport;cellular response to organonitrogen compound;single-organism organelle organization;organic substance metabolic process;cellular response to organic substance;neuron projection morphogenesis;neurotrophin signaling pathway;positive regulation of potassium ion transmembrane transport;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;mitotic cell cycle;positive regulation of phosphate metabolic process;microtubule nucleation;innate immune response;protein complex assembly;cellular protein modification process;regulation of phosphorus metabolic process;ion transmembrane transport;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;cell-cell signaling;cell communication;neurogenesis;small GTPase mediated signal transduction;cellular protein complex assembly;localization;single-organism localization;immune response-regulating signaling pathway;locomotion;primary metabolic process;generation of neurons;microtubule-based process;cytoskeleton organization;cell part morphogenesis;nervous system development;immune system process;anatomical structure development;cellular metabolic process;cellular response to endogenous stimulus;phosphate-containing compound metabolic process;cellular component biogenesis;response to peptide;cellular response to peptide;phosphorus metabolic process;epidermal growth factor receptor signaling pathway;regulation of protein phosphorylation;positive regulation of protein phosphorylation;microtubule cytoskeleton organization;positive regulation of cellular process; 6;4;3;6;4;3;3;9;4;4;5;6;6;5;4;4;3;4;3;4;4;2;5;5;7;5;6;4;2;3;4;7;4;3;4;4;7;4;6;3;4;6;5;5;4;7;3;7;8;3;3;4;4;6;5;6;7;6;6;5;5;4;4;3;6;7;6;7;5;4;4;5;5;8;2;5;3;6;5;4;6;5;3;6;5;5;2;2;6;3;3;4;4;6;6;8;6;5;4;3;3;6;5;5;1;2;3;7;5;5;4;3;8;4;5;2;6;3;5;6;6;7;4;4;5;5;6;4;3;4;4;6;5;5;5;3;7;6;2;8;4;3;6;4;4;6;7;5;6;3;3;6;4;5;5;5;5;3;4;7;8;5;6;7;2;4;8;2;6;5;2;4;5;7;7;8;3;5;4;5;7;4;5;6;4;6;7;4;5;4;4;8;4;7;8;8;6;4;8;4;4;5;5;5;7;6;4;7;6;7;5;4;5;5;7;5;5;5;4;3;5;6;6;6;5;6;7;5;6;6;4;5;6;5;5;4;5;3;4;4;6;6;6;2;3;5;2;3;7;4;5;5;5;2;3;3;4;5;3;5;6;4;9;7;7;5;3; GO:0031224;GO:0034703;GO:0031984;GO:0016020;GO:0005795;GO:0005794;GO:1902495;GO:0008076;GO:0015630;GO:0043231;GO:0044424;GO:0044425;GO:0005829;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0005856;GO:0031226;GO:0044431;GO:0044430;GO:0005737;GO:1990351;GO:0012505;GO:0043234;GO:0044446;GO:0016021;GO:0044444;GO:0098797;GO:0044459;GO:0032991;GO:0005815;GO:0044464;GO:0005623;GO:0034702;GO:0034705;GO:0071944;GO:0043232;GO:0098791;GO:0005575;GO:0005813;GO:0005622;GO:0005887;GO:0005886;GO:0005801;GO:0098796;GO:0043226; intrinsic component of membrane;cation channel complex;organelle subcompartment;membrane;Golgi stack;Golgi apparatus;transmembrane transporter complex;voltage-gated potassium channel complex;microtubule cytoskeleton;intracellular membrane-bounded organelle;intracellular part;membrane part;cytosol;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;cytoskeleton;intrinsic component of plasma membrane;Golgi apparatus part;cytoskeletal part;cytoplasm;transporter complex;endomembrane system;protein complex;intracellular organelle part;integral component of membrane;cytoplasmic part;plasma membrane protein complex;plasma membrane part;macromolecular complex;microtubule organizing center;cell part;cell;ion channel complex;potassium channel complex;cell periphery;intracellular non-membrane-bounded organelle;Golgi subcompartment;cellular_component;centrosome;intracellular;integral component of plasma membrane;plasma membrane;cis-Golgi network;membrane protein complex;organelle; 3;6;4;2;5;4;4;5;6;4;3;2;5;2;3;3;3;5;4;4;4;4;4;3;3;3;4;4;4;3;2;5;2;2;5;7;3;4;5;1;5;3;4;3;5;3;2; GO:0044325;GO:0034237;GO:0005102;GO:0003674;GO:0005488;GO:0098772;GO:0015459;GO:0005515;GO:0032947;GO:0005198;GO:0016247;GO:0051018; ion channel binding;protein kinase A regulatory subunit binding;receptor binding;molecular_function;binding;molecular function regulator;potassium channel regulator activity;protein binding;protein complex scaffold;structural molecule activity;channel regulator activity;protein kinase A binding; 4;5;4;1;2;2;4;3;3;2;3;4; K16551 IPR005539;IPR028745;IPR019528; ELK domain;A-kinase anchor protein 9;Pericentrin/AKAP-450 centrosomal targeting domain; nucleus Q5T619 Zinc finger protein 648 OS=Homo sapiens OX=9606 GN=ZNF648 PE=2 SV=1 - [ZN648_HUMAN] 0.97 1.117 0.879 1.095 1.184 0.668 0.868397493 0.004913026 0.924831081 0.803061448 0.786929275 0.089088034 0.564189189 0.106000217 GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; IPR013087; Zinc finger C2H2-type; nucleus Hs17488774 1173.0 R [R] General function prediction only; Q6UB98 Ankyrin repeat domain-containing protein 12 OS=Homo sapiens OX=9606 GN=ANKRD12 PE=1 SV=3 - [ANR12_HUMAN] 1.179 1.128 0.744 1.123 1.158 0.747 1.045212766 nan 0.969775475 nan 0.659574468 nan 0.64507772 nan GO:0005737;GO:0044446;GO:0043231;GO:0031981;GO:0043233;GO:0005634;GO:0005654;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0043229;GO:0044428;GO:0031974;GO:0044424;GO:0043227;GO:0043226;GO:0044422; cytoplasm;intracellular organelle part;intracellular membrane-bounded organelle;nuclear lumen;organelle lumen;nucleus;nucleoplasm;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;intracellular organelle;nuclear part;membrane-enclosed lumen;intracellular part;membrane-bounded organelle;organelle;organelle part; 4;3;4;5;3;5;5;2;2;3;1;4;3;4;2;3;3;2;2; K21436 IPR002110;IPR020683; Ankyrin repeat;Ankyrin repeat-containing domain; nucleus Hs14140238 4200.0 S [S] Function unknown; Q9Y236 Oxidative stress-induced growth inhibitor 2 OS=Homo sapiens OX=9606 GN=OSGIN2 PE=2 SV=1 - [OSGI2_HUMAN] 1.05 1.165 1.032 0.802 1.226 0.567 0.901287554 nan 0.654159869 nan 0.88583691 nan 0.462479608 nan GO:0044702;GO:0051321;GO:0000003;GO:0009987;GO:0022414;GO:0008150;GO:0007049;GO:0044763;GO:0044699; single organism reproductive process;meiotic cell cycle;reproduction;cellular process;reproductive process;biological_process;cell cycle;single-organism cellular process;single-organism process; 3;3;2;2;2;1;4;3;2; GO:0003674;GO:0003824;GO:0016491; molecular_function;catalytic activity;oxidoreductase activity; 1;2;3; IPR029731;IPR029728;IPR023753; OKL38 family;Oxidative stress-induced growth inhibitor 2;FAD/NAD(P)-binding domain; cytosol 169827473 54.3 O [O] Posttranslational modification, protein turnover, chaperones; COG0492 Thioredoxin reductase Q8TAP6 Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1 - [CEP76_HUMAN] 1.014 1.098 0.985 1.048 1.229 0.419 0.923497268 nan 0.852725793 nan 0.89708561 nan 0.340927583 nan GO:0022607;GO:0051493;GO:0044839;GO:0033043;GO:0000086;GO:0050789;GO:1903047;GO:0051128;GO:0044770;GO:0010824;GO:0044772;GO:0022402;GO:0098534;GO:0032886;GO:0031023;GO:0007049;GO:0046599;GO:1902115;GO:0071840;GO:0010564;GO:0016043;GO:0065007;GO:0044699;GO:0006996;GO:0000278;GO:0051297;GO:0009987;GO:0050794;GO:0000226;GO:0046605;GO:0008150;GO:1902589;GO:0007010;GO:0070925;GO:0051298;GO:0007017;GO:0051726;GO:0044087;GO:0044085;GO:0007098;GO:0007099;GO:0044763;GO:0070507; cellular component assembly;regulation of cytoskeleton organization;cell cycle G2/M phase transition;regulation of organelle organization;G2/M transition of mitotic cell cycle;regulation of biological process;mitotic cell cycle process;regulation of cellular component organization;cell cycle phase transition;regulation of centrosome duplication;mitotic cell cycle phase transition;cell cycle process;centriole assembly;regulation of microtubule-based process;microtubule organizing center organization;cell cycle;regulation of centriole replication;regulation of organelle assembly;cellular component organization or biogenesis;regulation of cell cycle process;cellular component organization;biological regulation;single-organism process;organelle organization;mitotic cell cycle;centrosome organization;cellular process;regulation of cellular process;microtubule cytoskeleton organization;regulation of centrosome cycle;biological_process;single-organism organelle organization;cytoskeleton organization;organelle assembly;centrosome duplication;microtubule-based process;regulation of cell cycle;regulation of cellular component biogenesis;cellular component biogenesis;centrosome cycle;centriole replication;single-organism cellular process;regulation of microtubule cytoskeleton organization; 4;6;6;5;6;2;5;4;5;6;6;4;5;4;5;4;5;4;2;5;3;2;2;4;5;6;2;3;5;6;1;4;5;5;5;4;4;3;3;5;5;3;5; GO:0043228;GO:0005814;GO:0043226;GO:0005856;GO:0044446;GO:0005813;GO:0005737;GO:0005815;GO:0044430;GO:0044450;GO:0015630;GO:0043234;GO:0032991;GO:0043232;GO:0005829;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422; non-membrane-bounded organelle;centriole;organelle;cytoskeleton;intracellular organelle part;centrosome;cytoplasm;microtubule organizing center;cytoskeletal part;microtubule organizing center part;microtubule cytoskeleton;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cytosol;cell part;intracellular organelle;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part; 3;5;2;5;3;5;4;5;4;5;6;3;2;4;5;2;3;2;3;1;4;3;2; K16457 IPR028926; CEP76, C2 domain; cytosol Q13547 Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1 - [HDAC1_HUMAN] 1.481 0.828 0.707 1.335 0.858 1.218 1.788647343 nan 1.555944056 nan 0.853864734 nan 1.41958042 nan GO:0032922;GO:0080090;GO:0019222;GO:0006476;GO:1901362;GO:0071840;GO:0044710;GO:0010605;GO:0048511;GO:0048519;GO:0016570;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0019538;GO:0019438;GO:0016568;GO:0016569;GO:0009892;GO:0009890;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:0044267;GO:0044260;GO:0016043;GO:0016575;GO:0065007;GO:0070933;GO:0018130;GO:0007623;GO:0006139;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0098732;GO:0044699;GO:0031327;GO:0032501;GO:0035601;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051253;GO:0051252;GO:0010629;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0006325;GO:1901360;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0010468;GO:0045934;GO:1901576;GO:0019219;GO:0006464;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:1902589;GO:0048523; circadian regulation of gene expression;regulation of primary metabolic process;regulation of metabolic process;protein deacetylation;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism metabolic process;negative regulation of macromolecule metabolic process;rhythmic process;negative regulation of biological process;histone modification;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;protein metabolic process;aromatic compound biosynthetic process;chromatin modification;covalent chromatin modification;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;histone deacetylation;biological regulation;histone H4 deacetylation;heterocycle biosynthetic process;circadian rhythm;nucleobase-containing compound metabolic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule deacylation;single-organism process;negative regulation of cellular biosynthetic process;multicellular organismal process;protein deacylation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;single-organism organelle organization;negative regulation of cellular process; 4;4;3;8;5;2;3;4;2;2;4;4;6;4;3;4;5;6;7;3;4;3;4;2;7;5;4;3;5;2;6;5;3;4;4;3;5;5;1;2;5;5;5;6;5;6;5;6;4;4;5;6;2;5;2;7;2;4;7;7;6;5;5;5;4;5;4;4;5;5;4;6;6;3;5;5;5;4;5;6;6;3;5;3;4;4;4;3;5;3;4;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:1901363;GO:0004407;GO:0001067;GO:0044212;GO:0016810;GO:0016811;GO:0033558;GO:0031078;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0016787;GO:0003824;GO:0097159;GO:0000976;GO:0000975;GO:0043565;GO:1990837;GO:0003690;GO:0034979;GO:0032041;GO:0019213;GO:0017136; heterocyclic compound binding;histone deacetylase activity;regulatory region nucleic acid binding;transcription regulatory region DNA binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;protein deacetylase activity;histone deacetylase activity (H3-K14 specific);molecular_function;binding;nucleic acid binding;DNA binding;hydrolase activity;catalytic activity;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;NAD-dependent protein deacetylase activity;NAD-dependent histone deacetylase activity (H3-K14 specific);deacetylase activity;NAD-dependent histone deacetylase activity; 3;6;5;7;4;5;5;7;1;2;4;5;3;2;3;8;6;6;7;6;6;8;4;7; K06067 map04110;map04213;map04330;map04919;map05016;map05034;map05169;map05200;map05202;map05203;map05220; Cell cycle;Longevity regulating pathway - multiple species;Notch signaling pathway;Thyroid hormone signaling pathway;Huntington's disease;Alcoholism;Epstein-Barr virus infection;Pathways in cancer;Transcriptional misregulation in cancer;Viral carcinogenesis;Chronic myeloid leukemia; IPR023801;IPR003084;IPR000286; Histone deacetylase domain;Histone deacetylase;Histone deacetylase superfamily; cytosol Hs13128860 1008.0 B [B] Chromatin structure and dynamics; P50454 Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2 - [SERPH_HUMAN] 0.85 1.141 1.296 1.03 0.913 0.733 0.744960561 nan 1.128148959 nan 1.135845749 nan 0.802847755 nan GO:0019222;GO:0048468;GO:0001501;GO:0071840;GO:0080090;GO:0044710;GO:0006986;GO:0010605;GO:0048869;GO:0048513;GO:0044092;GO:0002062;GO:0048519;GO:0003413;GO:0060255;GO:0030162;GO:0010033;GO:0051216;GO:0044707;GO:0019538;GO:0030199;GO:0030198;GO:0009892;GO:0043170;GO:0044267;GO:0051346;GO:0044260;GO:0052547;GO:0016043;GO:0065007;GO:0065009;GO:0048705;GO:0009887;GO:0050790;GO:0009888;GO:0050794;GO:0006950;GO:0044711;GO:0008150;GO:0008152;GO:0051336;GO:0051604;GO:0050896;GO:0030154;GO:0032964;GO:0032963;GO:0009653;GO:0043086;GO:0044699;GO:0051248;GO:0051246;GO:0006508;GO:0060350;GO:0060351;GO:0032501;GO:0009987;GO:0044259;GO:0032269;GO:0032268;GO:0035966;GO:0048731;GO:0045861;GO:0032502;GO:0048856;GO:0002063;GO:0043933;GO:0031324;GO:0031323;GO:0060349;GO:0060348;GO:0007275;GO:0071822;GO:0050789;GO:0071704;GO:0010467;GO:0010466;GO:0043062;GO:0003433;GO:1901576;GO:0052548;GO:0061448;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0010951;GO:0042221;GO:0044238;GO:0044237;GO:0044236;GO:0048523; regulation of metabolic process;cell development;skeletal system development;cellular component organization or biogenesis;regulation of primary metabolic process;single-organism metabolic process;response to unfolded protein;negative regulation of macromolecule metabolic process;cellular developmental process;animal organ development;negative regulation of molecular function;chondrocyte differentiation;negative regulation of biological process;chondrocyte differentiation involved in endochondral bone morphogenesis;regulation of macromolecule metabolic process;regulation of proteolysis;response to organic substance;cartilage development;single-multicellular organism process;protein metabolic process;collagen fibril organization;extracellular matrix organization;negative regulation of metabolic process;macromolecule metabolic process;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of peptidase activity;cellular component organization;biological regulation;regulation of molecular function;skeletal system morphogenesis;organ morphogenesis;regulation of catalytic activity;tissue development;regulation of cellular process;response to stress;single-organism biosynthetic process;biological_process;metabolic process;regulation of hydrolase activity;protein maturation;response to stimulus;cell differentiation;collagen biosynthetic process;collagen metabolic process;anatomical structure morphogenesis;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;proteolysis;endochondral bone morphogenesis;cartilage development involved in endochondral bone morphogenesis;multicellular organismal process;cellular process;multicellular organismal macromolecule metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;response to topologically incorrect protein;system development;negative regulation of proteolysis;developmental process;anatomical structure development;chondrocyte development;macromolecular complex subunit organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;bone morphogenesis;bone development;multicellular organism development;protein complex subunit organization;regulation of biological process;organic substance metabolic process;gene expression;negative regulation of peptidase activity;extracellular structure organization;chondrocyte development involved in endochondral bone morphogenesis;organic substance biosynthetic process;regulation of endopeptidase activity;connective tissue development;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;negative regulation of endopeptidase activity;response to chemical;primary metabolic process;cellular metabolic process;multicellular organism metabolic process;negative regulation of cellular process; 3;4;5;2;4;3;5;4;4;4;4;6;2;5;4;6;4;5;3;4;6;5;3;4;5;6;4;6;3;2;3;5;4;4;4;3;3;4;1;2;5;5;2;5;5;6;3;5;2;5;5;5;6;4;2;2;5;5;5;4;4;6;2;3;5;4;4;4;5;4;4;5;2;3;5;7;4;6;4;7;5;3;3;5;3;8;3;3;3;4;3; GO:0005783;GO:0005788;GO:0031982;GO:0016020;GO:0005793;GO:0098589;GO:0031974;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044432;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0098805;GO:1903561;GO:0045121;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;endoplasmic reticulum lumen;vesicle;membrane;endoplasmic reticulum-Golgi intermediate compartment;membrane region;membrane-enclosed lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;membrane part;membrane microdomain;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;endoplasmic reticulum part;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;extracellular exosome;whole membrane;extracellular vesicle;membrane raft;cellular_component;intracellular organelle lumen;extracellular region; 4;5;4;2;5;3;2;3;4;3;3;2;4;2;2;3;3;2;4;3;3;4;4;2;2;3;4;3;3;5;1;4;2; GO:0030414;GO:0098772;GO:1901363;GO:0044877;GO:0004866;GO:0003674;GO:0005488;GO:0003676;GO:0061135;GO:0097159;GO:0004857;GO:0032403;GO:0044822;GO:0004867;GO:0003723;GO:0005515;GO:0005518;GO:0030234;GO:0061134; peptidase inhibitor activity;molecular function regulator;heterocyclic compound binding;macromolecular complex binding;endopeptidase inhibitor activity;molecular_function;binding;nucleic acid binding;endopeptidase regulator activity;organic cyclic compound binding;enzyme inhibitor activity;protein complex binding;poly(A) RNA binding;serine-type endopeptidase inhibitor activity;RNA binding;protein binding;collagen binding;enzyme regulator activity;peptidase regulator activity; 5;2;3;3;6;1;2;4;5;3;4;4;6;7;5;3;5;3;4; K09501 IPR023795;IPR033830;IPR000215;IPR023796;IPR033547; Serpin, conserved site;Serpin H1 inhibitory domain;Serpin family;Serpin domain;Serpin H1; extracellular Hs4502597 855.0 V [V] Defense mechanisms; Q8N0X2 Sperm-associated antigen 16 protein OS=Homo sapiens OX=9606 GN=SPAG16 PE=2 SV=2 - [SPG16_HUMAN] nan nan nan nan nan nan nan 0.042950694 nan 0.042875021 nan 0.006063795 nan 0.015144886 GO:0048468;GO:0003341;GO:0071840;GO:0051716;GO:0000003;GO:0048869;GO:0048515;GO:0019953;GO:0051592;GO:0003006;GO:0007283;GO:0010038;GO:0007286;GO:0007288;GO:0010035;GO:0051704;GO:0044703;GO:0044702;GO:0048870;GO:0044782;GO:0022607;GO:0097231;GO:0006928;GO:0000226;GO:0000902;GO:0035082;GO:0016043;GO:0048646;GO:0042384;GO:0060271;GO:0071277;GO:0008150;GO:0001578;GO:0050896;GO:0044763;GO:0071248;GO:0030154;GO:0071241;GO:0010927;GO:0070887;GO:0009653;GO:0044699;GO:0060285;GO:0032502;GO:0006996;GO:0032501;GO:0048609;GO:0032504;GO:0051012;GO:0009987;GO:0048232;GO:0048858;GO:0060294;GO:0051674;GO:0030030;GO:0030031;GO:0007276;GO:0032989;GO:0044767;GO:0022414;GO:0001539;GO:0022412;GO:0042221;GO:0070925;GO:0051179;GO:0040011;GO:0007281;GO:0007017;GO:0007010;GO:0032990;GO:0048856;GO:0007018;GO:1902589;GO:0044085; cell development;cilium movement;cellular component organization or biogenesis;cellular response to stimulus;reproduction;cellular developmental process;spermatid differentiation;sexual reproduction;response to calcium ion;developmental process involved in reproduction;spermatogenesis;response to metal ion;spermatid development;sperm axoneme assembly;response to inorganic substance;multi-organism process;multi-organism reproductive process;single organism reproductive process;cell motility;cilium organization;cellular component assembly;cell motility in response to calcium ion;movement of cell or subcellular component;microtubule cytoskeleton organization;cell morphogenesis;axoneme assembly;cellular component organization;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;cellular response to calcium ion;biological_process;microtubule bundle formation;response to stimulus;single-organism cellular process;cellular response to metal ion;cell differentiation;cellular response to inorganic substance;cellular component assembly involved in morphogenesis;cellular response to chemical stimulus;anatomical structure morphogenesis;single-organism process;cilium-dependent cell motility;developmental process;organelle organization;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;microtubule sliding;cellular process;male gamete generation;cell projection morphogenesis;cilium movement involved in cell motility;localization of cell;cell projection organization;cell projection assembly;gamete generation;cellular component morphogenesis;single-organism developmental process;reproductive process;cilium or flagellum-dependent cell motility;cellular process involved in reproduction in multicellular organism;response to chemical;organelle assembly;localization;locomotion;germ cell development;microtubule-based process;cytoskeleton organization;cell part morphogenesis;anatomical structure development;microtubule-based movement;single-organism organelle organization;cellular component biogenesis; 4;6;2;3;2;4;4;3;6;3;6;5;5;4;4;2;3;3;3;5;4;4;4;5;5;5;3;3;5;6;7;1;6;2;3;6;5;5;4;4;3;2;5;2;4;2;3;3;6;2;5;5;4;3;4;5;4;4;3;2;4;4;3;5;2;2;4;4;5;5;3;5;4;3; GO:0042995;GO:0031514;GO:0043231;GO:0043232;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0043227;GO:0043226;GO:0005856;GO:0005930;GO:0044447;GO:0097014;GO:0044441;GO:0005737;GO:0005634;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:1990716;GO:0005575; cell projection;motile cilium;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;membrane-bounded organelle;organelle;cytoskeleton;axoneme;axoneme part;ciliary plasm;ciliary part;cytoplasm;nucleus;cell projection part;cell part;cell;intracellular;axonemal central apparatus;cellular_component; 3;4;4;4;3;2;3;3;3;3;2;5;4;4;4;3;4;5;3;2;2;3;5;1; IPR020472;IPR017986;IPR001680;IPR015943;IPR019775;IPR011042; G-protein beta WD-40 repeat;WD40-repeat-containing domain;WD40 repeat;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;Six-bladed beta-propeller, TolB-like; mitochondria 17230958 184.0 T [T] Signal transduction mechanisms; COG5635 Predicted NTPase, NACHT family domain A4UGR9 Xin actin-binding repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=XIRP2 PE=1 SV=2 - [XIRP2_HUMAN] 1.037 1.008 0.941 1.186 1.168 0.647 1.028769841 nan 1.015410959 nan 0.933531746 nan 0.553938356 nan GO:0034330;GO:0003281;GO:0030036;GO:0072359;GO:0072358;GO:0061061;GO:0009653;GO:0007275;GO:0044699;GO:0003205;GO:0007517;GO:0016043;GO:0048513;GO:0071840;GO:0048729;GO:0048644;GO:0032502;GO:0009887;GO:0032501;GO:0030029;GO:0055008;GO:0009987;GO:0009888;GO:0003007;GO:0008150;GO:0045216;GO:0003231;GO:0006996;GO:0007507;GO:0007010;GO:0003279;GO:0044707;GO:0048856;GO:0044763;GO:0014706;GO:0048738;GO:1902589;GO:0044767;GO:0060537;GO:0048731;GO:0060415; cell junction organization;ventricular septum development;actin cytoskeleton organization;circulatory system development;cardiovascular system development;muscle structure development;anatomical structure morphogenesis;multicellular organism development;single-organism process;cardiac chamber development;muscle organ development;cellular component organization;animal organ development;cellular component organization or biogenesis;tissue morphogenesis;muscle organ morphogenesis;developmental process;organ morphogenesis;multicellular organismal process;actin filament-based process;cardiac muscle tissue morphogenesis;cellular process;tissue development;heart morphogenesis;biological_process;cell-cell junction organization;cardiac ventricle development;organelle organization;heart development;cytoskeleton organization;cardiac septum development;single-multicellular organism process;anatomical structure development;single-organism cellular process;striated muscle tissue development;cardiac muscle tissue development;single-organism organelle organization;single-organism developmental process;muscle tissue development;system development;muscle tissue morphogenesis; 4;5;5;5;5;4;3;4;2;4;5;3;4;2;4;5;2;4;2;4;6;2;4;5;1;5;5;4;4;5;4;3;3;3;6;5;4;3;5;4;5; GO:0043229;GO:0044464;GO:0043232;GO:0031674;GO:0030016;GO:0030017;GO:0005575;GO:0044444;GO:0043226;GO:0030018;GO:0005737;GO:0043292;GO:0030054;GO:0005623;GO:0005622;GO:0043228;GO:0044422;GO:0044424;GO:0044449; intracellular organelle;cell part;intracellular non-membrane-bounded organelle;I band;myofibril;sarcomere;cellular_component;cytoplasmic part;organelle;Z disc;cytoplasm;contractile fiber;cell junction;cell;intracellular;non-membrane-bounded organelle;organelle part;intracellular part;contractile fiber part; 3;2;4;4;6;4;1;4;2;4;4;5;2;2;3;3;2;3;3; IPR030107;IPR030072;IPR012510; Xin actin-binding repeat-containing protein 2;Xin actin-binding repeat-containing protein 1/2;Actin-binding, Xin repeat; nucleus P00451 Coagulation factor VIII OS=Homo sapiens OX=9606 GN=F8 PE=1 SV=1 - [FA8_HUMAN] 1.111 1.058 0.697 1.286 0.991 1.558 1.050094518 nan 1.297679112 nan 0.65879017 nan 1.572149344 nan GO:0007599;GO:0007597;GO:0007596;GO:0006901;GO:0006900;GO:0006903;GO:0061024;GO:1901576;GO:0051656;GO:0051650;GO:0071840;GO:0044710;GO:0018196;GO:0009611;GO:0018193;GO:0051668;GO:0030168;GO:0016192;GO:0044707;GO:0019538;GO:0016050;GO:0022607;GO:0006950;GO:0044267;GO:0006888;GO:0044260;GO:0006887;GO:0016043;GO:0045055;GO:0065003;GO:0065007;GO:0065008;GO:0006810;GO:0042060;GO:0006952;GO:0006953;GO:0043412;GO:0043413;GO:0044802;GO:0008152;GO:0044723;GO:0002526;GO:0051234;GO:0090114;GO:0046903;GO:0046907;GO:0050896;GO:0009058;GO:0036211;GO:0008150;GO:0050817;GO:0006954;GO:0070271;GO:0001775;GO:0044249;GO:0034645;GO:0044699;GO:0051640;GO:0032501;GO:1902591;GO:0050878;GO:0043687;GO:0009987;GO:1901137;GO:1901135;GO:0032940;GO:0043170;GO:0048208;GO:0043933;GO:0048207;GO:0009100;GO:0009101;GO:0071822;GO:0006487;GO:0072378;GO:0002576;GO:0071704;GO:0044085;GO:0018279;GO:0048193;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0044765;GO:0009059;GO:0044763;GO:0051648;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0006486;GO:0072376;GO:0044237;GO:1902589;GO:1902582;GO:1902580; hemostasis;blood coagulation, intrinsic pathway;blood coagulation;vesicle coating;membrane budding;vesicle targeting;membrane organization;organic substance biosynthetic process;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;single-organism metabolic process;peptidyl-asparagine modification;response to wounding;peptidyl-amino acid modification;localization within membrane;platelet activation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;vesicle organization;cellular component assembly;response to stress;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;exocytosis;cellular component organization;regulated exocytosis;macromolecular complex assembly;biological regulation;regulation of biological quality;transport;wound healing;defense response;acute-phase response;macromolecule modification;macromolecule glycosylation;single-organism membrane organization;metabolic process;single-organism carbohydrate metabolic process;acute inflammatory response;establishment of localization;COPII-coated vesicle budding;secretion;intracellular transport;response to stimulus;biosynthetic process;protein modification process;biological_process;coagulation;inflammatory response;protein complex biogenesis;cell activation;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;organelle localization;multicellular organismal process;single-organism membrane budding;regulation of body fluid levels;post-translational protein modification;cellular process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;secretion by cell;macromolecule metabolic process;COPII vesicle coating;macromolecular complex subunit organization;vesicle targeting, rough ER to cis-Golgi;glycoprotein metabolic process;glycoprotein biosynthetic process;protein complex subunit organization;protein N-linked glycosylation;blood coagulation, fibrin clot formation;platelet degranulation;organic substance metabolic process;cellular component biogenesis;protein N-linked glycosylation via asparagine;Golgi vesicle transport;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;vesicle localization;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;protein glycosylation;protein activation cascade;cellular metabolic process;single-organism organelle organization;single-organism intracellular transport;single-organism cellular localization; 5;4;5;6;5;4;4;4;4;5;2;3;8;4;7;4;5;5;3;4;5;4;3;5;7;4;5;3;6;5;2;3;4;5;4;7;5;6;4;2;4;6;3;5;5;5;2;3;5;1;4;5;4;4;4;5;2;4;2;5;4;7;2;5;4;4;4;6;4;6;5;6;5;5;4;7;3;3;6;6;5;5;5;6;4;5;3;5;4;2;3;3;4;3;4;4;3;3;4;5;4; GO:0005783;GO:0044433;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0005794;GO:0099503;GO:0098588;GO:0031974;GO:0034774;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0030135;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0030141;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0097708;GO:0016020;GO:0005788;GO:0005886;GO:0033116;GO:0060205;GO:0005737;GO:0031091;GO:0031090;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0071944;GO:0030133;GO:0005615;GO:0005793;GO:0030134;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;cytoplasmic vesicle part;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;Golgi apparatus;secretory vesicle;bounding membrane of organelle;membrane-enclosed lumen;secretory granule lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;coated vesicle;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;secretory granule;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intracellular vesicle;membrane;endoplasmic reticulum lumen;plasma membrane;endoplasmic reticulum-Golgi intermediate compartment membrane;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;organelle membrane;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;cell periphery;transport vesicle;extracellular space;endoplasmic reticulum-Golgi intermediate compartment;ER to Golgi transport vesicle;cellular_component;intracellular organelle lumen;extracellular region; 4;4;4;4;5;5;4;6;4;2;5;4;3;3;2;2;6;3;3;3;2;4;4;4;3;5;3;4;4;2;5;3;5;5;4;5;3;6;5;2;2;3;4;3;5;5;1;4;2; GO:0046872;GO:0003674;GO:0005488;GO:0046914;GO:0003824;GO:0016491;GO:0043169;GO:0043167;GO:0005507; metal ion binding;molecular_function;binding;transition metal ion binding;catalytic activity;oxidoreductase activity;cation binding;ion binding;copper ion binding; 5;1;2;6;2;3;4;3;7; K03899 map04610; Complement and coagulation cascades; IPR024715;IPR011707;IPR011706;IPR001117;IPR000421;IPR033138;IPR008979;IPR008972;IPR014707; Coagulation factor 5/8-like;Multicopper oxidase, type 3;Multicopper oxidase, type 2;Multicopper oxidase, type 1;Coagulation factor 5/8 C-terminal domain;Multicopper oxidases, conserved site;Galactose-binding domain-like;Cupredoxin;Coagulation factor 8; extracellular 392375945 213.0 DPM [D] Cell cycle control, cell division, chromosome partitioning; [P] Inorganic ion transport and metabolism; [M] Cell wall/membrane/envelope biogenesis; COG2132 Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA) P00450 Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1 - [CERU_HUMAN] 1.076 0.965 0.928 1.124 0.977 0.97 1.115025907 1.19E-33 1.150460594 2.26E-70 0.961658031 8.46E-09 0.99283521 2.02E-20 GO:0055072;GO:0006825;GO:0098771;GO:0044707;GO:0048513;GO:0065007;GO:0019725;GO:0010038;GO:0010035;GO:0065008;GO:0009605;GO:0031667;GO:0048878;GO:0061008;GO:0055076;GO:0046916;GO:0006812;GO:0006811;GO:0006810;GO:0008150;GO:0051234;GO:0050896;GO:0000041;GO:0050801;GO:0044699;GO:0032502;GO:0032501;GO:0006879;GO:0006875;GO:0009987;GO:0006873;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0055085;GO:0007568;GO:0048731;GO:0048732;GO:0060541;GO:0009991;GO:0030323;GO:0030324;GO:1990267;GO:0042592;GO:0001889;GO:0007275;GO:0046688;GO:0007584;GO:0044767;GO:0044765;GO:0044763;GO:0055065;GO:0042221;GO:0035295;GO:0051179;GO:1902578;GO:0048856; iron ion homeostasis;copper ion transport;inorganic ion homeostasis;single-multicellular organism process;animal organ development;biological regulation;cellular homeostasis;response to metal ion;response to inorganic substance;regulation of biological quality;response to external stimulus;response to nutrient levels;chemical homeostasis;hepaticobiliary system development;transition metal ion homeostasis;cellular transition metal ion homeostasis;cation transport;ion transport;transport;biological_process;establishment of localization;response to stimulus;transition metal ion transport;ion homeostasis;single-organism process;developmental process;multicellular organismal process;cellular iron ion homeostasis;cellular metal ion homeostasis;cellular process;cellular ion homeostasis;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;aging;system development;gland development;respiratory system development;response to extracellular stimulus;respiratory tube development;lung development;response to transition metal nanoparticle;homeostatic process;liver development;multicellular organism development;response to copper ion;response to nutrient;single-organism developmental process;single-organism transport;single-organism cellular process;metal ion homeostasis;response to chemical;tube development;localization;single-organism localization;anatomical structure development; 10;9;7;3;4;2;4;5;4;3;3;5;5;5;9;9;6;5;4;1;3;2;8;6;2;2;2;10;8;2;6;7;7;7;5;4;4;4;4;5;4;4;4;4;4;5;4;5;4;3;4;3;8;3;4;2;3;3; GO:0031982;GO:0005773;GO:0016020;GO:0005774;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0098852;GO:0046658;GO:0043229;GO:0043227;GO:0043226;GO:0072562;GO:0044437;GO:0031224;GO:0031225;GO:0044446;GO:0044444;GO:0044422;GO:0000323;GO:0005886;GO:0031226;GO:0005737;GO:0031090;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005764;GO:0070062;GO:0098805;GO:1903561;GO:0005615;GO:0005575;GO:0005765;GO:0005576; vesicle;vacuole;membrane;vacuolar membrane;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;lytic vacuole membrane;anchored component of plasma membrane;intracellular organelle;membrane-bounded organelle;organelle;blood microparticle;vacuolar part;intrinsic component of membrane;anchored component of membrane;intracellular organelle part;cytoplasmic part;organelle part;lytic vacuole;plasma membrane;intrinsic component of plasma membrane;cytoplasm;organelle membrane;plasma membrane part;cell part;cell;intracellular;cell periphery;lysosome;extracellular exosome;whole membrane;extracellular vesicle;extracellular space;cellular_component;lysosomal membrane;extracellular region; 4;5;2;4;4;3;4;3;2;2;5;4;3;3;2;3;4;3;4;3;4;2;6;3;4;4;3;3;2;2;3;3;7;4;3;3;3;1;6;2; GO:0046872;GO:0003674;GO:0005488;GO:0046914;GO:0003824;GO:0016491;GO:0043169;GO:0004322;GO:0051087;GO:0043167;GO:0005507;GO:0005515;GO:0016722;GO:0016724; metal ion binding;molecular_function;binding;transition metal ion binding;catalytic activity;oxidoreductase activity;cation binding;ferroxidase activity;chaperone binding;ion binding;copper ion binding;protein binding;oxidoreductase activity, oxidizing metal ions;oxidoreductase activity, oxidizing metal ions, oxygen as acceptor; 5;1;2;6;2;3;4;6;4;3;7;3;4;5; K13624 map00860; Porphyrin and chlorophyll metabolism; IPR011707;IPR011706;IPR027150;IPR001117;IPR033138;IPR008972;IPR002355; Multicopper oxidase, type 3;Multicopper oxidase, type 2;Ceruloplasmin;Multicopper oxidase, type 1;Multicopper oxidases, conserved site;Cupredoxin;Multicopper oxidase, copper-binding site; endoplasmic reticulum Hs4557485 2237.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q08380 Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1 - [LG3BP_HUMAN] 0.868 0.878 1.227 0.869 0.89 1.293 0.988610478 0.883826103 0.976404494 0.629436256 1.397494305 0.000195845 1.452808989 0.003222064 GO:0006968;GO:0007154;GO:0044699;GO:0051716;GO:0050789;GO:0065007;GO:0022610;GO:0009987;GO:0006810;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0023052;GO:0007155;GO:0006897;GO:0051234;GO:0051179;GO:0044700;GO:0016192;GO:0050896;GO:0006898;GO:0044763;GO:0007165; cellular defense response;cell communication;single-organism process;cellular response to stimulus;regulation of biological process;biological regulation;biological adhesion;cellular process;transport;regulation of cellular process;defense response;response to stress;biological_process;signaling;cell adhesion;endocytosis;establishment of localization;localization;single organism signaling;vesicle-mediated transport;response to stimulus;receptor-mediated endocytosis;single-organism cellular process;signal transduction; 5;4;2;3;2;2;2;2;4;3;4;3;1;2;3;6;3;2;3;5;2;7;3;4; GO:0031012;GO:0043227;GO:0043226;GO:1903561;GO:0070062;GO:0005615;GO:0016020;GO:0072562;GO:0031982;GO:0043230;GO:0005578;GO:0005575;GO:0005576;GO:0044421; extracellular matrix;membrane-bounded organelle;organelle;extracellular vesicle;extracellular exosome;extracellular space;membrane;blood microparticle;vesicle;extracellular organelle;proteinaceous extracellular matrix;cellular_component;extracellular region;extracellular region part; 2;3;2;3;4;3;2;3;4;3;3;1;2;2; GO:0060089;GO:0038024;GO:0003674;GO:0004872;GO:0005044; molecular transducer activity;cargo receptor activity;molecular_function;receptor activity;scavenger receptor activity; 2;4;1;3;5; K17300 IPR017448;IPR000210;IPR011705;IPR001190; SRCR-like domain;BTB/POZ domain;BTB/Kelch-associated;SRCR domain; extracellular Q16610 Extracellular matrix protein 1 OS=Homo sapiens OX=9606 GN=ECM1 PE=1 SV=2 - [ECM1_HUMAN] 0.887 0.975 1.107 1.076 1 1.013 0.90974359 0.257335758 1.076 0.647758381 1.135384615 0.283276506 1.013 0.266914104 GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0072359;GO:0001503;GO:0007165;GO:0007166;GO:0030500;GO:1901576;GO:0030502;GO:1901362;GO:1901360;GO:0019221;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0009967;GO:0010467;GO:0048513;GO:0048514;GO:0044092;GO:0048518;GO:0048519;GO:0043122;GO:0043123;GO:0042127;GO:0002828;GO:0060255;GO:0070167;GO:0050776;GO:0030162;GO:2001141;GO:0010033;GO:0046483;GO:0044700;GO:0034654;GO:0044707;GO:0048870;GO:0019538;GO:0002376;GO:0072358;GO:0019438;GO:0060759;GO:0009892;GO:0070887;GO:0022603;GO:0006928;GO:1901342;GO:0051674;GO:0035556;GO:0050673;GO:0050789;GO:0097659;GO:0044267;GO:0010646;GO:0051346;GO:0044260;GO:0006357;GO:0001568;GO:2000401;GO:0002685;GO:0065007;GO:0001960;GO:0006366;GO:0065009;GO:0016477;GO:0048646;GO:0018130;GO:0070168;GO:0034097;GO:0050793;GO:0050790;GO:0009889;GO:0009888;GO:0050794;GO:0006952;GO:0072676;GO:0008150;GO:0008152;GO:0006955;GO:0060761;GO:1902533;GO:0030278;GO:0030279;GO:0072678;GO:0051336;GO:2000404;GO:0044271;GO:0071345;GO:0050896;GO:0006950;GO:0006355;GO:0010556;GO:2000145;GO:0006351;GO:0042092;GO:0006954;GO:0051239;GO:0001944;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:1902531;GO:0023051;GO:0010647;GO:0009653;GO:0043086;GO:0044699;GO:0006139;GO:0051248;GO:1904018;GO:0051240;GO:0051241;GO:0051246;GO:0006508;GO:0032502;GO:0016070;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0034645;GO:0040012;GO:0032879;GO:0051093;GO:0042221;GO:0032269;GO:0032268;GO:0050678;GO:0050679;GO:0001959;GO:0051094;GO:0051252;GO:0007249;GO:0043170;GO:0006807;GO:0048731;GO:0045861;GO:0008284;GO:0032774;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0050900;GO:0001525;GO:0007275;GO:0002682;GO:2000112;GO:0045765;GO:0045766;GO:0030282;GO:0071704;GO:0071310;GO:0010466;GO:0010468;GO:0030334;GO:0052547;GO:0019219;GO:0044249;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0031214;GO:0007154;GO:0051179;GO:0040011;GO:0044238;GO:0051270;GO:0048856;GO:0044237;GO:0001938;GO:2000026;GO:0001936;GO:0001935;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;ossification;signal transduction;cell surface receptor signaling pathway;regulation of bone mineralization;organic substance biosynthetic process;negative regulation of bone mineralization;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cytokine-mediated signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;gene expression;animal organ development;blood vessel morphogenesis;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell proliferation;regulation of type 2 immune response;regulation of macromolecule metabolic process;regulation of biomineral tissue development;regulation of immune response;regulation of proteolysis;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;single organism signaling;nucleobase-containing compound biosynthetic process;single-multicellular organism process;cell motility;protein metabolic process;immune system process;cardiovascular system development;aromatic compound biosynthetic process;regulation of response to cytokine stimulus;negative regulation of metabolic process;cellular response to chemical stimulus;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;regulation of vasculature development;localization of cell;intracellular signal transduction;epithelial cell proliferation;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;regulation of cell communication;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;blood vessel development;regulation of lymphocyte migration;regulation of leukocyte migration;biological regulation;negative regulation of cytokine-mediated signaling pathway;transcription from RNA polymerase II promoter;regulation of molecular function;cell migration;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;negative regulation of biomineral tissue development;response to cytokine;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;tissue development;regulation of cellular process;defense response;lymphocyte migration;biological_process;metabolic process;immune response;negative regulation of response to cytokine stimulus;positive regulation of intracellular signal transduction;regulation of ossification;negative regulation of ossification;T cell migration;regulation of hydrolase activity;regulation of T cell migration;cellular nitrogen compound biosynthetic process;cellular response to cytokine stimulus;response to stimulus;response to stress;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;regulation of cell motility;transcription, DNA-templated;type 2 immune response;inflammatory response;regulation of multicellular organismal process;vasculature development;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;regulation of intracellular signal transduction;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;negative regulation of catalytic activity;single-organism process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;positive regulation of vasculature development;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;proteolysis;developmental process;RNA metabolic process;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular macromolecule biosynthetic process;regulation of locomotion;regulation of localization;negative regulation of developmental process;response to chemical;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of epithelial cell proliferation;positive regulation of epithelial cell proliferation;regulation of cytokine-mediated signaling pathway;positive regulation of developmental process;regulation of RNA metabolic process;I-kappaB kinase/NF-kappaB signaling;macromolecule metabolic process;nitrogen compound metabolic process;system development;negative regulation of proteolysis;positive regulation of cell proliferation;RNA biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;leukocyte migration;angiogenesis;multicellular organism development;regulation of immune system process;regulation of cellular macromolecule biosynthetic process;regulation of angiogenesis;positive regulation of angiogenesis;bone mineralization;organic substance metabolic process;cellular response to organic substance;negative regulation of peptidase activity;regulation of gene expression;regulation of cell migration;regulation of peptidase activity;regulation of nucleobase-containing compound metabolic process;cellular biosynthetic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;biomineral tissue development;cell communication;localization;locomotion;primary metabolic process;regulation of cellular component movement;anatomical structure development;cellular metabolic process;positive regulation of endothelial cell proliferation;regulation of multicellular organismal development;regulation of endothelial cell proliferation;endothelial cell proliferation;negative regulation of cellular process;positive regulation of cellular process; 4;3;3;3;3;5;4;4;5;5;4;5;5;4;6;3;4;4;4;4;5;4;4;4;2;2;6;6;4;5;4;5;4;6;6;4;4;3;5;3;3;4;2;5;5;4;3;4;4;4;5;3;5;4;2;7;5;4;6;4;7;4;5;4;2;5;7;3;4;3;5;4;5;3;4;4;4;3;4;4;1;2;3;4;5;4;4;5;5;6;5;6;2;3;6;5;4;6;4;5;3;5;3;3;4;2;4;5;3;4;3;5;2;4;5;4;3;3;5;5;2;5;2;3;2;4;7;5;3;3;3;3;5;5;5;5;5;3;5;6;4;3;4;6;4;6;5;4;4;5;3;4;4;3;6;5;5;5;3;5;7;5;5;6;5;4;3;3;5;3;4;5;4;2;2;3;4;3;3;6;4;6;5;3;3; GO:0031982;GO:0043230;GO:0044421;GO:0043227;GO:0031012;GO:0005615;GO:1903561;GO:0070062;GO:0005575;GO:0005576;GO:0043226;GO:0005578; vesicle;extracellular organelle;extracellular region part;membrane-bounded organelle;extracellular matrix;extracellular space;extracellular vesicle;extracellular exosome;cellular_component;extracellular region;organelle;proteinaceous extracellular matrix; 4;3;2;3;2;3;3;4;1;2;2;3; GO:0050840;GO:0043236;GO:0003674;GO:0005488;GO:0008022;GO:0019899;GO:0002020;GO:0005515;GO:0004871; extracellular matrix binding;laminin binding;molecular_function;binding;protein C-terminus binding;enzyme binding;protease binding;protein binding;signal transducer activity; 3;4;1;2;4;4;5;3;2; IPR008605;IPR020858; Extracellular matrix protein 1;Serum albumin-like; extracellular Q6UWY0 Arylsulfatase K OS=Homo sapiens OX=9606 GN=ARSK PE=1 SV=1 - [ARSK_HUMAN] 1.093 1.021 0.97 0.882 1.318 0.601 1.070519099 nan 0.669195751 nan 0.950048972 nan 0.45599393 nan GO:0006807;GO:0044699;GO:0006629;GO:0044267;GO:0044710;GO:0044260;GO:0071704;GO:0006687;GO:0006664;GO:0006665;GO:1903509;GO:0006643;GO:0043687;GO:0009987;GO:0006464;GO:0044281;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044255;GO:0044238;GO:1901564;GO:0019538;GO:1901135;GO:0044237;GO:0043170;GO:0044763; nitrogen compound metabolic process;single-organism process;lipid metabolic process;cellular protein metabolic process;single-organism metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;glycosphingolipid metabolic process;glycolipid metabolic process;sphingolipid metabolic process;liposaccharide metabolic process;membrane lipid metabolic process;post-translational protein modification;cellular process;cellular protein modification process;small molecule metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;cellular lipid metabolic process;primary metabolic process;organonitrogen compound metabolic process;protein metabolic process;carbohydrate derivative metabolic process;cellular metabolic process;macromolecule metabolic process;single-organism cellular process; 3;2;4;5;3;4;3;6;6;5;5;5;7;2;6;4;5;5;1;2;4;3;4;4;4;3;4;3; GO:0005783;GO:0031974;GO:0043229;GO:0005623;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0044432;GO:0044446;GO:0005788;GO:0043231;GO:0043233;GO:0044464;GO:0005575;GO:0070013;GO:0044444;GO:0005576;GO:0044424;GO:0044422;GO:0012505; endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;cell;intracellular;membrane-bounded organelle;organelle;cytoplasm;endoplasmic reticulum part;intracellular organelle part;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;cell part;cellular_component;intracellular organelle lumen;cytoplasmic part;extracellular region;intracellular part;organelle part;endomembrane system; 4;2;3;2;3;3;2;4;4;3;5;4;3;2;1;4;4;2;3;2;3; GO:0005488;GO:0016787;GO:0003674;GO:0008484;GO:0043167;GO:0004065;GO:0046872;GO:0016788;GO:0043169;GO:0003824; binding;hydrolase activity;molecular_function;sulfuric ester hydrolase activity;ion binding;arylsulfatase activity;metal ion binding;hydrolase activity, acting on ester bonds;cation binding;catalytic activity; 2;3;1;5;3;6;5;4;4;2; K12376 IPR000917;IPR017850;IPR017849; Sulfatase, N-terminal;Alkaline-phosphatase-like, core domain;Alkaline phosphatase-like, alpha/beta/alpha; endoplasmic reticulum Hs18561376 251.0 G [G] Carbohydrate transport and metabolism; O43149 Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6 - [ZZEF1_HUMAN] 0.916 0.741 1.179 1.006 0.781 2.223 1.236167341 0.857422758 1.28809219 0.132416055 1.591093117 0.362149613 2.846350832 0.033596452 GO:0043169;GO:0046914;GO:0008270;GO:0043167;GO:0003674;GO:0005488;GO:0046872;GO:0005509; cation binding;transition metal ion binding;zinc ion binding;ion binding;molecular_function;binding;metal ion binding;calcium ion binding; 4;6;7;3;1;2;5;6; IPR008979;IPR000433;IPR000859;IPR004939;IPR011992;IPR002048; Galactose-binding domain-like;Zinc finger, ZZ-type;CUB domain;APC10/DOC domain;EF-hand domain pair;EF-hand domain; plasma membrane P12235 ADP/ATP translocase 1 OS=Homo sapiens OX=9606 GN=SLC25A4 PE=1 SV=4 - [ADT1_HUMAN] 1.341 0.89 0.762 1.2 0.868 1.654 1.506741573 nan 1.382488479 nan 0.856179775 nan 1.905529954 nan GO:0090087;GO:0008104;GO:0051046;GO:0051049;GO:0044281;GO:0071840;GO:0044710;GO:0000002;GO:0043043;GO:0010467;GO:0044419;GO:0048519;GO:0033036;GO:0060544;GO:0060547;GO:0060546;GO:0060548;GO:0045184;GO:0090276;GO:0055114;GO:0051704;GO:0044700;GO:1901564;GO:1901566;GO:0019538;GO:0034641;GO:0015853;GO:0015851;GO:0006807;GO:0051223;GO:0030072;GO:0030073;GO:1901576;GO:0050708;GO:0044260;GO:0016043;GO:0065007;GO:0007005;GO:0065008;GO:0070201;GO:0009306;GO:0006810;GO:0050796;GO:0050794;GO:0012501;GO:0008150;GO:0008152;GO:0051234;GO:0046903;GO:0044271;GO:0015980;GO:0009058;GO:0009059;GO:0097300;GO:0006518;GO:0006863;GO:0044249;GO:0015833;GO:0023052;GO:1903530;GO:0034645;GO:0023051;GO:0010646;GO:0044699;GO:0032880;GO:0046879;GO:0042886;GO:0006112;GO:0070265;GO:0070266;GO:0010939;GO:0009987;GO:0046883;GO:0032879;GO:0043604;GO:0008637;GO:0043603;GO:0032940;GO:0060341;GO:0043170;GO:0008219;GO:0010941;GO:0006091;GO:0050789;GO:0071705;GO:0071704;GO:0043067;GO:0071702;GO:0043069;GO:0044267;GO:0006915;GO:0023061;GO:0010817;GO:0044765;GO:0044764;GO:0044763;GO:0007267;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0002790;GO:0002791;GO:0044237;GO:0009914;GO:0016032;GO:0015031;GO:0044403;GO:0006412;GO:0048523; regulation of peptide transport;protein localization;regulation of secretion;regulation of transport;small molecule metabolic process;cellular component organization or biogenesis;single-organism metabolic process;mitochondrial genome maintenance;peptide biosynthetic process;gene expression;interspecies interaction between organisms;negative regulation of biological process;macromolecule localization;regulation of necroptotic process;negative regulation of necrotic cell death;negative regulation of necroptotic process;negative regulation of cell death;establishment of protein localization;regulation of peptide hormone secretion;oxidation-reduction process;multi-organism process;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular nitrogen compound metabolic process;adenine transport;nucleobase transport;nitrogen compound metabolic process;regulation of protein transport;peptide hormone secretion;insulin secretion;organic substance biosynthetic process;regulation of protein secretion;cellular macromolecule metabolic process;cellular component organization;biological regulation;mitochondrion organization;regulation of biological quality;regulation of establishment of protein localization;protein secretion;transport;regulation of insulin secretion;regulation of cellular process;programmed cell death;biological_process;metabolic process;establishment of localization;secretion;cellular nitrogen compound biosynthetic process;energy derivation by oxidation of organic compounds;biosynthetic process;macromolecule biosynthetic process;programmed necrotic cell death;peptide metabolic process;purine nucleobase transport;cellular biosynthetic process;peptide transport;signaling;regulation of secretion by cell;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;single-organism process;regulation of protein localization;hormone secretion;amide transport;energy reserve metabolic process;necrotic cell death;necroptotic process;regulation of necrotic cell death;cellular process;regulation of hormone secretion;regulation of localization;amide biosynthetic process;apoptotic mitochondrial changes;cellular amide metabolic process;secretion by cell;regulation of cellular localization;macromolecule metabolic process;cell death;regulation of cell death;generation of precursor metabolites and energy;regulation of biological process;nitrogen compound transport;organic substance metabolic process;regulation of programmed cell death;organic substance transport;negative regulation of programmed cell death;cellular protein metabolic process;apoptotic process;signal release;regulation of hormone levels;single-organism transport;multi-organism cellular process;single-organism cellular process;cell-cell signaling;cell communication;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;peptide secretion;regulation of peptide secretion;cellular metabolic process;hormone transport;viral process;protein transport;symbiosis, encompassing mutualism through parasitism;translation;negative regulation of cellular process; 5;4;5;4;4;2;3;6;6;5;3;2;3;6;5;6;4;4;5;4;2;3;4;5;4;4;7;5;3;5;7;6;4;6;4;3;2;5;3;5;5;4;6;3;5;1;2;3;5;5;4;3;5;6;5;6;4;6;2;5;5;3;4;2;4;6;5;5;5;7;5;2;4;3;6;6;5;4;4;4;4;4;4;2;5;3;5;5;5;5;6;5;4;4;3;3;4;4;2;3;3;4;3;6;6;3;5;4;5;4;6;3; GO:0031975;GO:0031224;GO:0043209;GO:0016021;GO:0016020;GO:0031967;GO:0031966;GO:0043231;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0019866;GO:0043229;GO:0043227;GO:0043226;GO:0044446;GO:0044444;GO:0031226;GO:0005737;GO:0031090;GO:0005634;GO:0005739;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0071944;GO:0005887;GO:0005886;GO:0005575; envelope;intrinsic component of membrane;myelin sheath;integral component of membrane;membrane;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;mitochondrial part;intracellular part;membrane part;organelle part;organelle inner membrane;intracellular organelle;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasmic part;intrinsic component of plasma membrane;cytoplasm;organelle membrane;nucleus;mitochondrion;plasma membrane part;cell part;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;cell periphery;integral component of plasma membrane;plasma membrane;cellular_component; 3;3;3;4;2;4;4;4;4;3;2;2;4;3;3;2;3;4;4;4;3;5;5;3;2;2;3;5;5;3;4;3;1; GO:0005198;GO:0003735;GO:0003674;GO:0022891;GO:0022892;GO:0005345;GO:0005215;GO:0015207;GO:0015205;GO:0022857; structural molecule activity;structural constituent of ribosome;molecular_function;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;purine nucleobase transmembrane transporter activity;transporter activity;adenine transmembrane transporter activity;nucleobase transmembrane transporter activity;transmembrane transporter activity; 2;3;1;4;3;6;2;7;5;3; K05863 map04020;map04022;map05012;map05016;map05166; Calcium signaling pathway;cGMP-PKG signaling pathway;Parkinson's disease;Huntington's disease;HTLV-I infection; IPR002113;IPR018108;IPR023395;IPR002067; Adenine nucleotide translocator 1;Mitochondrial substrate/solute carrier;Mitochondrial carrier domain;Mitochondrial carrier protein; mitochondria Hs13647558 610.0 C [C] Energy production and conversion; Q9P2H0 Centrosomal protein of 126 kDa OS=Homo sapiens OX=9606 GN=CEP126 PE=1 SV=3 - [CE126_HUMAN] 1.142 1.045 1.003 1.093 0.936 0.933 1.092822967 nan 1.167735043 nan 0.959808612 nan 0.996794872 nan GO:0022607;GO:0030030;GO:0030031;GO:1903047;GO:0010927;GO:0000226;GO:0009653;GO:0044699;GO:0000278;GO:0000902;GO:0071822;GO:0048869;GO:0016043;GO:0032989;GO:0043933;GO:0071840;GO:0007010;GO:0048646;GO:0032502;GO:0042384;GO:0035058;GO:0060271;GO:0009987;GO:0031122;GO:0044767;GO:0007051;GO:0007052;GO:0008150;GO:0070925;GO:0032990;GO:0006996;GO:0007049;GO:0007017;GO:0048858;GO:0022402;GO:0048856;GO:1902589;GO:0044085;GO:0044763;GO:0044782; cellular component assembly;cell projection organization;cell projection assembly;mitotic cell cycle process;cellular component assembly involved in morphogenesis;microtubule cytoskeleton organization;anatomical structure morphogenesis;single-organism process;mitotic cell cycle;cell morphogenesis;protein complex subunit organization;cellular developmental process;cellular component organization;cellular component morphogenesis;macromolecular complex subunit organization;cellular component organization or biogenesis;cytoskeleton organization;anatomical structure formation involved in morphogenesis;developmental process;cilium assembly;nonmotile primary cilium assembly;cilium morphogenesis;cellular process;cytoplasmic microtubule organization;single-organism developmental process;spindle organization;mitotic spindle organization;biological_process;organelle assembly;cell part morphogenesis;organelle organization;cell cycle;microtubule-based process;cell projection morphogenesis;cell cycle process;anatomical structure development;single-organism organelle organization;cellular component biogenesis;single-organism cellular process;cilium organization; 4;4;5;5;4;5;3;2;5;5;5;4;3;4;4;2;5;3;2;5;6;6;2;6;3;5;6;1;5;5;4;4;4;5;4;3;4;3;3;5; GO:0044463;GO:0043229;GO:0015630;GO:0005929;GO:0043226;GO:0005737;GO:0044446;GO:0042995;GO:0044430;GO:0005856;GO:0044441;GO:0030496;GO:0043228;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0097546;GO:0005813;GO:0044424;GO:0005815;GO:0044422; cell projection part;intracellular organelle;microtubule cytoskeleton;cilium;organelle;cytoplasm;intracellular organelle part;cell projection;cytoskeletal part;cytoskeleton;ciliary part;midbody;non-membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;ciliary base;centrosome;intracellular part;microtubule organizing center;organelle part; 3;3;6;3;2;4;3;3;4;5;3;3;3;4;2;2;3;1;4;5;3;5;2; IPR028257; Centrosomal protein of 126kDa; nucleus Q6NUN7 Jhy protein homolog OS=Homo sapiens OX=9606 GN=JHY PE=2 SV=1 - [JHY_HUMAN] 0.33 0.298 3.332 0.464 0.366 0.443 1.10738255 nan 1.267759563 nan 11.18120805 nan 1.210382514 nan GO:0022607;GO:0050878;GO:0065008;GO:0033326;GO:0030030;GO:0030031;GO:0010927;GO:0031023;GO:0000226;GO:0009653;GO:0007275;GO:0071840;GO:0007420;GO:0060322;GO:0051234;GO:0000902;GO:0035082;GO:0048869;GO:0016043;GO:0032989;GO:0048513;GO:0065007;GO:0044699;GO:0006810;GO:0007417;GO:0048646;GO:0032502;GO:0042384;GO:0060271;GO:0007589;GO:0032501;GO:0009987;GO:0032053;GO:0044767;GO:0044765;GO:0008150;GO:0048731;GO:0070925;GO:0051179;GO:1902578;GO:0048858;GO:0006996;GO:0046903;GO:0007017;GO:0007010;GO:0032990;GO:0044707;GO:0001578;GO:0048856;GO:0007399;GO:1902589;GO:0044085;GO:0032941;GO:0044763;GO:0044782; cellular component assembly;regulation of body fluid levels;regulation of biological quality;cerebrospinal fluid secretion;cell projection organization;cell projection assembly;cellular component assembly involved in morphogenesis;microtubule organizing center organization;microtubule cytoskeleton organization;anatomical structure morphogenesis;multicellular organism development;cellular component organization or biogenesis;brain development;head development;establishment of localization;cell morphogenesis;axoneme assembly;cellular developmental process;cellular component organization;cellular component morphogenesis;animal organ development;biological regulation;single-organism process;transport;central nervous system development;anatomical structure formation involved in morphogenesis;developmental process;cilium assembly;cilium morphogenesis;body fluid secretion;multicellular organismal process;cellular process;ciliary basal body organization;single-organism developmental process;single-organism transport;biological_process;system development;organelle assembly;localization;single-organism localization;cell projection morphogenesis;organelle organization;secretion;microtubule-based process;cytoskeleton organization;cell part morphogenesis;single-multicellular organism process;microtubule bundle formation;anatomical structure development;nervous system development;single-organism organelle organization;cellular component biogenesis;secretion by tissue;single-organism cellular process;cilium organization; 4;4;3;5;4;5;4;5;5;3;4;2;4;4;3;5;5;4;3;4;4;2;2;4;5;3;2;5;6;5;2;2;6;3;4;1;4;5;2;3;5;4;5;4;5;5;3;6;3;5;4;3;4;3;5; IPR027968; Protein of unknown function DUF4591; nucleus Q07075 Glutamyl aminopeptidase OS=Homo sapiens OX=9606 GN=ENPEP PE=1 SV=3 - [AMPE_HUMAN] 1.126 1.132 0.946 1.028 0.997 0.795 0.994699647 0.892247941 1.03109328 0.89392864 0.835689046 0.164894974 0.797392177 0.73842397 GO:0080090;GO:0019222;GO:0072359;GO:0072358;GO:0044712;GO:0042445;GO:0044710;GO:0044254;GO:0001822;GO:0048513;GO:0048514;GO:0060255;GO:0006928;GO:0030163;GO:1901564;GO:0001991;GO:0001990;GO:0003008;GO:0044700;GO:0016477;GO:1901565;GO:0044707;GO:0048870;GO:0019538;GO:0003081;GO:0003013;GO:0060177;GO:0006807;GO:0051179;GO:0044266;GO:0044267;GO:1901575;GO:0044243;GO:0001568;GO:0044268;GO:0065007;GO:0065008;GO:0048646;GO:0008015;GO:0008150;GO:0008152;GO:0051604;GO:0006518;GO:0043171;GO:0051246;GO:0044248;GO:0034641;GO:0023052;GO:0009653;GO:0044699;GO:0050886;GO:0001944;GO:0006508;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0001655;GO:0044259;GO:0016485;GO:0044256;GO:0072001;GO:0016486;GO:0072006;GO:0003044;GO:0043603;GO:0043170;GO:0051674;GO:0048731;GO:0008217;GO:0001525;GO:0007275;GO:0002002;GO:0002003;GO:0002005;GO:0050789;GO:0071704;GO:0010467;GO:0032835;GO:0003073;GO:0007586;GO:0010817;GO:0044767;GO:0044763;GO:0007267;GO:0007154;GO:0009056;GO:0009057;GO:0040011;GO:0044238;GO:0044260;GO:0048856;GO:0044237;GO:0044236; regulation of primary metabolic process;regulation of metabolic process;circulatory system development;cardiovascular system development;single-organism catabolic process;hormone metabolic process;single-organism metabolic process;multicellular organismal protein catabolic process;kidney development;animal organ development;blood vessel morphogenesis;regulation of macromolecule metabolic process;movement of cell or subcellular component;protein catabolic process;organonitrogen compound metabolic process;regulation of systemic arterial blood pressure by circulatory renin-angiotensin;regulation of systemic arterial blood pressure by hormone;system process;single organism signaling;cell migration;organonitrogen compound catabolic process;single-multicellular organism process;cell motility;protein metabolic process;regulation of systemic arterial blood pressure by renin-angiotensin;circulatory system process;regulation of angiotensin metabolic process;nitrogen compound metabolic process;localization;multicellular organismal macromolecule catabolic process;cellular protein metabolic process;organic substance catabolic process;multicellular organism catabolic process;blood vessel development;multicellular organismal protein metabolic process;biological regulation;regulation of biological quality;anatomical structure formation involved in morphogenesis;blood circulation;biological_process;metabolic process;protein maturation;peptide metabolic process;peptide catabolic process;regulation of protein metabolic process;cellular catabolic process;cellular nitrogen compound metabolic process;signaling;anatomical structure morphogenesis;single-organism process;endocrine process;vasculature development;proteolysis;developmental process;multicellular organismal process;cell proliferation;cellular process;urogenital system development;multicellular organismal macromolecule metabolic process;protein processing;protein digestion;renal system development;peptide hormone processing;nephron development;regulation of systemic arterial blood pressure mediated by a chemical signal;cellular amide metabolic process;macromolecule metabolic process;localization of cell;system development;regulation of blood pressure;angiogenesis;multicellular organism development;regulation of angiotensin levels in blood;angiotensin maturation;angiotensin catabolic process in blood;regulation of biological process;organic substance metabolic process;gene expression;glomerulus development;regulation of systemic arterial blood pressure;digestion;regulation of hormone levels;single-organism developmental process;single-organism cellular process;cell-cell signaling;cell communication;catabolic process;macromolecule catabolic process;locomotion;primary metabolic process;cellular macromolecule metabolic process;anatomical structure development;cellular metabolic process;multicellular organism metabolic process; 4;3;5;5;4;3;3;5;4;4;4;4;4;5;4;7;5;3;3;4;5;3;3;4;6;4;6;3;2;6;5;4;5;4;5;2;3;3;5;1;2;5;5;5;5;4;4;2;3;2;4;5;5;2;2;3;2;5;5;6;5;5;4;4;6;5;4;3;4;4;4;4;5;5;4;2;3;5;4;5;4;4;3;3;4;4;3;5;2;3;4;3;3;4; GO:0031982;GO:0005773;GO:0016021;GO:0016020;GO:0005774;GO:0044437;GO:0098862;GO:0098588;GO:0098589;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0031226;GO:0097708;GO:0031090;GO:0031224;GO:0044446;GO:0044444;GO:0098852;GO:0000323;GO:0098590;GO:0005903;GO:0005737;GO:0045177;GO:0031410;GO:0044459;GO:0016324;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0005764;GO:0070062;GO:0005887;GO:0005886;GO:1903561;GO:0005575;GO:0005765;GO:0005576;GO:0098805; vesicle;vacuole;integral component of membrane;membrane;vacuolar membrane;vacuolar part;cluster of actin-based cell projections;bounding membrane of organelle;membrane region;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;intracellular organelle;intracellular;membrane-bounded organelle;organelle;intrinsic component of plasma membrane;intracellular vesicle;organelle membrane;intrinsic component of membrane;intracellular organelle part;cytoplasmic part;lytic vacuole membrane;lytic vacuole;plasma membrane region;brush border;cytoplasm;apical part of cell;cytoplasmic vesicle;plasma membrane part;apical plasma membrane;cell surface;cell part;cell;cell periphery;side of membrane;lysosome;extracellular exosome;integral component of plasma membrane;plasma membrane;extracellular vesicle;cellular_component;lysosomal membrane;extracellular region;whole membrane; 4;5;4;2;4;4;3;4;3;3;4;3;2;2;2;4;3;3;3;2;4;4;3;3;3;4;5;6;4;4;4;3;5;3;4;3;2;2;3;3;7;4;4;3;3;1;6;2;3; GO:0008270;GO:0070006;GO:0003674;GO:0005488;GO:0046914;GO:0008237;GO:0016787;GO:0003824;GO:0008238;GO:0008233;GO:0008235;GO:0043169;GO:0042277;GO:0043167;GO:0033218;GO:0046872;GO:0004177;GO:0070011; zinc ion binding;metalloaminopeptidase activity;molecular_function;binding;transition metal ion binding;metallopeptidase activity;hydrolase activity;catalytic activity;exopeptidase activity;peptidase activity;metalloexopeptidase activity;cation binding;peptide binding;ion binding;amide binding;metal ion binding;aminopeptidase activity;peptidase activity, acting on L-amino acid peptides; 7;8;1;2;6;6;3;2;6;4;7;4;4;3;3;5;7;5; K11141 map04614; Renin-angiotensin system; IPR034016;IPR001930;IPR014782;IPR033508;IPR024571; Aminopeptidase N-type;Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase;Peptidase M1, membrane alanine aminopeptidase, N-terminal;Aminopeptidase A;ERAP1-like C-terminal domain; extracellular Hs20534524 1996.0 EO [E] Amino acid transport and metabolism;[O] Posttranslational modification, protein turnover, chaperones; Q96N16 Janus kinase and microtubule-interacting protein 1 OS=Homo sapiens OX=9606 GN=JAKMIP1 PE=1 SV=1 - [JKIP1_HUMAN] 0.793 1.326 0.81 2.07 0.392 1.266 0.598039216 nan 5.280612245 nan 0.610859729 nan 3.229591837 nan GO:0008104;GO:0071702;GO:0033036;GO:0032501;GO:0050877;GO:0006810;GO:0045184;GO:0015031;GO:0008150;GO:0051234;GO:0051179;GO:0003008;GO:0050890; protein localization;organic substance transport;macromolecule localization;multicellular organismal process;neurological system process;transport;establishment of protein localization;protein transport;biological_process;establishment of localization;localization;system process;cognition; 4;5;3;2;4;4;4;5;1;3;2;3;5; GO:0099512;GO:0099513;GO:0044464;GO:0019898;GO:0043226;GO:0043229;GO:0015630;GO:1990904;GO:0005874;GO:0005737;GO:0044446;GO:0016020;GO:0030529;GO:0044430;GO:0005856;GO:0032991;GO:0043232;GO:0005623;GO:0005622;GO:0005575;GO:0043228;GO:0044424;GO:0044425;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;cell part;extrinsic component of membrane;organelle;intracellular organelle;microtubule cytoskeleton;ribonucleoprotein complex;microtubule;cytoplasm;intracellular organelle part;membrane;intracellular ribonucleoprotein complex;cytoskeletal part;cytoskeleton;macromolecular complex;intracellular non-membrane-bounded organelle;cell;intracellular;cellular_component;non-membrane-bounded organelle;intracellular part;membrane part;organelle part; 2;3;2;3;2;3;6;3;4;4;3;2;4;4;5;2;4;2;3;1;3;3;2;2; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0050811;GO:0097159;GO:0003723;GO:0005515;GO:0005102; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;GABA receptor binding;organic cyclic compound binding;RNA binding;protein binding;receptor binding; 1;2;4;3;5;3;5;3;4; IPR031994;IPR024836; Janus kinase and microtubule-interacting protein, C-terminal domain;Janus kinase and microtubule-interacting protein; cytosol Q86YA3 Protein ZGRF1 OS=Homo sapiens OX=9606 GN=ZGRF1 PE=1 SV=3 - [ZGRF1_HUMAN] 1.405 1.379 0.7 0.837 1.11 0.463 1.018854242 0.636161488 0.754054054 0.164615879 0.507614213 0.000712401 0.417117117 0.027016762 GO:0016021;GO:0016020;GO:0005575;GO:0044425;GO:0031224; integral component of membrane;membrane;cellular_component;membrane part;intrinsic component of membrane; 4;2;1;2;3; GO:0043169;GO:0046914;GO:0043167;GO:0003674;GO:0005488;GO:0046872;GO:0008270; cation binding;transition metal ion binding;ion binding;molecular_function;binding;metal ion binding;zinc ion binding; 4;6;3;1;2;5;7; IPR010666;IPR027417;IPR018838; Zinc finger, GRF-type;P-loop containing nucleoside triphosphate hydrolase;Domain of unknown function DUF2439; plasma membrane Hs20162560 506.0 A [A] RNA processing and modification; Q24JQ0 Transmembrane protein 241 OS=Homo sapiens OX=9606 GN=TMEM241 PE=2 SV=1 - [TM241_HUMAN] 1.068 1.496 0.537 0.8 1.471 0.613 0.713903743 0.004171714 0.543847723 0.005765526 0.358957219 0.000712457 0.416723317 0.010136294 GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; IPR029666; GDP-fucose transporter; plasma membrane Hs22059556 385.0 GOU [G] Carbohydrate transport and metabolism;[O] Posttranslational modification, protein turnover, chaperones;[U] Intracellular trafficking, secretion, and vesicular transport; P17032 Zinc finger protein 37A OS=Homo sapiens OX=9606 GN=ZNF37A PE=2 SV=3 - [ZN37A_HUMAN] 1.129 0.919 1.516 0.892 0.881 nan 1.228509249 nan 1.012485812 nan 1.649619151 nan nan nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:0043170;GO:1901360;GO:0032774;GO:1901576;GO:0044260;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0060255;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0051252;GO:0006355;GO:0010556;GO:0006351;GO:0019438;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of macromolecule metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of RNA metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process; 4;3;5;4;5;4;4;3;5;4;4;6;4;4;5;6;2;3;5;2;7;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;5;6;5;6;5;3; GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 3;2;5;4;2;3;2;3;1;3; GO:0043169;GO:0003674;GO:0001071;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0003700;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;nucleic acid binding transcription factor activity;DNA binding;metal ion binding;nucleic acid binding;ion binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;2;5;5;4;3;3;3;3;2; K09228 IPR013087;IPR001909; Zinc finger C2H2-type;Krueppel-associated box; nucleus Hs22052519 1152.0 R [R] General function prediction only; Q32MZ4 Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2 - [LRRF1_HUMAN] 1.273 0.992 0.914 1.148 0.947 0.804 1.283266129 nan 1.212249208 nan 0.921370968 nan 0.848996832 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0048518;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0044707;GO:0002376;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0032481;GO:0006355;GO:0006357;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0051240;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051239;GO:0051253;GO:0051252;GO:0010629;GO:0043170;GO:0001816;GO:0001817;GO:0032479;GO:0001819;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0032606;GO:0090304;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045934;GO:0019219;GO:0045087;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;immune system process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;positive regulation of type I interferon production;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;positive regulation of multicellular organismal process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;regulation of multicellular organismal process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;cytokine production;regulation of cytokine production;regulation of type I interferon production;positive regulation of cytokine production;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;type I interferon production;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;innate immune response;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 4;3;5;4;4;2;2;4;6;4;3;2;5;3;4;3;7;4;4;2;7;5;4;3;4;3;1;2;3;5;5;5;2;5;6;7;6;5;6;4;4;5;2;4;3;2;2;4;7;7;6;3;5;5;5;4;4;4;5;4;5;5;4;4;5;5;6;6;2;3;5;5;5;5;5;4;6;3;5;4;4;3;3;3; GO:0016020;GO:0043232;GO:0005829;GO:0043231;GO:0044424;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0005856;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0071944;GO:0005634;GO:0005886;GO:0005575; membrane;intracellular non-membrane-bounded organelle;cytosol;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;cytoskeleton;cytoplasmic part;cytoplasm;cell part;cell;cell periphery;nucleus;plasma membrane;cellular_component; 2;4;5;4;3;3;3;3;3;2;5;4;4;2;2;3;5;3;1; GO:1901363;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0046983;GO:0042802;GO:0042803;GO:0003725;GO:0003723;GO:0005515;GO:0003674; heterocyclic compound binding;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;protein dimerization activity;identical protein binding;protein homodimerization activity;double-stranded RNA binding;RNA binding;protein binding;molecular_function; 3;2;4;5;3;4;4;5;6;5;3;1; IPR019139; Leucine-rich repeat flightless-interacting protein 1/2; nucleus Hs4758690 1581.0 R [R] General function prediction only; A0A0C4DH25 Immunoglobulin kappa variable 3D-20 OS=Homo sapiens OX=9606 GN=IGKV3D-20 PE=3 SV=1 - [KVD20_HUMAN] 0.995 1.015 1.104 0.942 0.986 1.179 0.980295567 0.468416473 0.955375254 0.719346667 1.087684729 0.784929935 1.195740365 0.226117603 IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular O15047 Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3 - [SET1A_HUMAN] 1.181 0.907 1.087 1.217 0.842 0.849 1.302094818 0.025379603 1.445368171 0.028983467 1.19845645 0.207294391 1.008313539 0.907391527 GO:0006479;GO:0080090;GO:0019222;GO:0051568;GO:1901362;GO:0071840;GO:0044710;GO:0018193;GO:0016571;GO:0016570;GO:0060255;GO:2001141;GO:0046483;GO:0019538;GO:0018205;GO:0019438;GO:0016569;GO:0018022;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:1901360;GO:0032259;GO:0018130;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0043414;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0034968;GO:0009987;GO:0006725;GO:1903506;GO:0008213;GO:0051252;GO:0043170;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0006325;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0044267;GO:0019219;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0016568;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:1902589; protein methylation;regulation of primary metabolic process;regulation of metabolic process;histone H3-K4 methylation;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism metabolic process;peptidyl-amino acid modification;histone methylation;histone modification;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;protein metabolic process;peptidyl-lysine modification;aromatic compound biosynthetic process;covalent chromatin modification;peptidyl-lysine methylation;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;methylation;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;macromolecule methylation;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;histone lysine methylation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;protein alkylation;regulation of RNA metabolic process;macromolecule metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;chromatin organization;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;chromatin modification;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;single-organism organelle organization; 5;4;3;7;5;2;3;7;5;4;4;6;4;4;8;5;7;6;3;7;4;4;3;2;4;3;5;4;3;5;5;1;2;5;5;5;6;5;6;4;6;4;4;5;2;4;6;2;4;7;7;5;4;4;5;4;5;5;6;2;3;5;5;5;5;6;3;5;3;4;6;4;3;5;3;4; GO:0031974;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0048188;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0005654;GO:0035097;GO:0044446;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0043228;GO:0005694;GO:0032991;GO:0034708;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;Set1C/COMPASS complex;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;nucleoplasm;histone methyltransferase complex;intracellular organelle part;nucleus;nucleoplasm part;cell part;cell;non-membrane-bounded organelle;chromosome;macromolecular complex;methyltransferase complex;cellular_component;intracellular organelle lumen; 2;5;4;5;3;4;4;3;6;4;3;2;3;3;3;2;7;6;5;5;3;5;5;2;2;3;5;2;4;1;4; GO:0008276;GO:1901363;GO:0000166;GO:0016740;GO:0016741;GO:0008170;GO:0018024;GO:0016278;GO:0016279;GO:0003674;GO:0005488;GO:0003676;GO:0008168;GO:0008013;GO:0003824;GO:0097159;GO:0042800;GO:0003723;GO:0005515;GO:0042054;GO:1901265;GO:0008757;GO:0036094; protein methyltransferase activity;heterocyclic compound binding;nucleotide binding;transferase activity;transferase activity, transferring one-carbon groups;N-methyltransferase activity;histone-lysine N-methyltransferase activity;lysine N-methyltransferase activity;protein-lysine N-methyltransferase activity;molecular_function;binding;nucleic acid binding;methyltransferase activity;beta-catenin binding;catalytic activity;organic cyclic compound binding;histone methyltransferase activity (H3-K4 specific);RNA binding;protein binding;histone methyltransferase activity;nucleoside phosphate binding;S-adenosylmethionine-dependent methyltransferase activity;small molecule binding; 6;3;4;3;4;6;8;7;7;1;2;4;5;4;2;3;9;5;3;7;4;6;3; K11422 map00310; Lysine degradation; IPR001214;IPR034467;IPR024657;IPR000504;IPR003616; SET domain;Set1A, RNA recognition motif;COMPASS complex Set1 subunit, N-SET domain;RNA recognition motif domain;Post-SET domain; nucleus 330827056 105.0 R [R] General function prediction only; COG2940 SET domain-containing protein (function unknown) P39900 Macrophage metalloelastase OS=Homo sapiens OX=9606 GN=MMP12 PE=1 SV=1 - [MMP12_HUMAN] 1.15 0.973 0.899 1.173 1.076 0.869 1.181911614 nan 1.090148699 nan 0.923946557 nan 0.807620818 nan GO:0008284;GO:0008152;GO:0048870;GO:0006928;GO:0043170;GO:0014070;GO:0051674;GO:0032963;GO:0035313;GO:0009653;GO:0050789;GO:0044699;GO:0044712;GO:0002009;GO:0044710;GO:0044243;GO:0044236;GO:0042127;GO:0071840;GO:0009611;GO:0016043;GO:0071704;GO:0050673;GO:0065007;GO:0048729;GO:0030198;GO:0048518;GO:0006508;GO:0016477;GO:0022617;GO:0010033;GO:0032502;GO:0060429;GO:0043062;GO:0008283;GO:0032501;GO:0009987;GO:0009888;GO:0042060;GO:0060054;GO:0044767;GO:0006950;GO:0008150;GO:0044259;GO:0042221;GO:0050794;GO:0009056;GO:0051179;GO:0050679;GO:0040011;GO:0044238;GO:0050678;GO:0044707;GO:0090504;GO:0090505;GO:0019538;GO:0050896;GO:0048856;GO:0042493;GO:0030574;GO:0002011;GO:0044319;GO:0044763;GO:0022411;GO:0048522; positive regulation of cell proliferation;metabolic process;cell motility;movement of cell or subcellular component;macromolecule metabolic process;response to organic cyclic compound;localization of cell;collagen metabolic process;wound healing, spreading of epidermal cells;anatomical structure morphogenesis;regulation of biological process;single-organism process;single-organism catabolic process;morphogenesis of an epithelium;single-organism metabolic process;multicellular organism catabolic process;multicellular organism metabolic process;regulation of cell proliferation;cellular component organization or biogenesis;response to wounding;cellular component organization;organic substance metabolic process;epithelial cell proliferation;biological regulation;tissue morphogenesis;extracellular matrix organization;positive regulation of biological process;proteolysis;cell migration;extracellular matrix disassembly;response to organic substance;developmental process;epithelium development;extracellular structure organization;cell proliferation;multicellular organismal process;cellular process;tissue development;wound healing;positive regulation of epithelial cell proliferation involved in wound healing;single-organism developmental process;response to stress;biological_process;multicellular organismal macromolecule metabolic process;response to chemical;regulation of cellular process;catabolic process;localization;positive regulation of epithelial cell proliferation;locomotion;primary metabolic process;regulation of epithelial cell proliferation;single-multicellular organism process;epiboly;epiboly involved in wound healing;protein metabolic process;response to stimulus;anatomical structure development;response to drug;collagen catabolic process;morphogenesis of an epithelial sheet;wound healing, spreading of cells;single-organism cellular process;cellular component disassembly;positive regulation of cellular process; 4;2;3;4;4;5;3;6;6;3;2;2;4;5;3;5;4;4;2;4;3;3;4;2;4;5;2;5;4;5;4;2;5;4;3;2;2;4;5;6;3;3;1;5;3;3;3;2;5;2;3;5;3;7;6;4;2;3;4;5;6;5;3;4;3; GO:0005576;GO:0005578;GO:0005575;GO:0031012;GO:0044421; extracellular region;proteinaceous extracellular matrix;cellular_component;extracellular matrix;extracellular region part; 2;3;1;2;2; GO:0004175;GO:0005509;GO:0043169;GO:0003674;GO:0005488;GO:0008233;GO:0046914;GO:0008270;GO:0043167;GO:0008237;GO:0016787;GO:0004222;GO:0003824;GO:0046872;GO:0070011; endopeptidase activity;calcium ion binding;cation binding;molecular_function;binding;peptidase activity;transition metal ion binding;zinc ion binding;ion binding;metallopeptidase activity;hydrolase activity;metalloendopeptidase activity;catalytic activity;metal ion binding;peptidase activity, acting on L-amino acid peptides; 6;6;4;1;2;4;6;7;3;6;3;7;2;5;5; K01413 IPR018487;IPR024079;IPR000585;IPR033739;IPR021190;IPR018486;IPR001818;IPR002477;IPR028718;IPR006026;IPR021158; Hemopexin-like repeats;Metallopeptidase, catalytic domain;Hemopexin-like domain;Peptidase M10A, catalytic domain;Peptidase M10A;Hemopexin, conserved site;Peptidase M10, metallopeptidase;Peptidoglycan binding-like;Macrophage metalloelastase;Peptidase, metallopeptidase;Peptidase M10A, cysteine switch, zinc binding site; extracellular Hs4505207 978.0 OW [O] Posttranslational modification, protein turnover, chaperones;[W] Extracellular structures; A0A0C4DH29 Immunoglobulin heavy variable 1-3 OS=Homo sapiens OX=9606 GN=IGHV1-3 PE=3 SV=1 - [HV103_HUMAN] 1.38 1.037 0.6 1.294 0.975 1.032 1.330761813 0.062114437 1.327179487 0.110072747 0.578592093 0.036450416 1.058461538 0.425502469 IPR013106;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like domain; extracellular P02775 Platelet basic protein OS=Homo sapiens OX=9606 GN=PPBP PE=1 SV=3 - [CXCL7_HUMAN] 0.983 0.934 1.329 0.918 0.952 0.95 1.052462527 0.817935902 0.964285714 0.892935876 1.422912206 0.04526073 0.99789916 0.967873416 GO:0007599;GO:0019221;GO:0007596;GO:0048583;GO:0050920;GO:0007165;GO:0007166;GO:0060326;GO:0008643;GO:0034219;GO:0051716;GO:0043207;GO:0009617;GO:0009611;GO:0002685;GO:0048518;GO:0002682;GO:0042127;GO:0030595;GO:0048584;GO:0030593;GO:0006935;GO:0051707;GO:0010033;GO:0030168;GO:0051704;GO:0044700;GO:0016477;GO:0009607;GO:0044707;GO:0009605;GO:0002275;GO:0048870;GO:0002376;GO:0007154;GO:0002274;GO:0050921;GO:0006928;GO:0045321;GO:0051674;GO:0042742;GO:0032496;GO:0050789;GO:0002283;GO:0008645;GO:0006887;GO:0051781;GO:0045055;GO:0002687;GO:0002684;GO:0002366;GO:0065007;GO:1904659;GO:0065008;GO:0007186;GO:0002688;GO:0035428;GO:0034097;GO:0006810;GO:0042060;GO:0050794;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0006954;GO:0006955;GO:0051234;GO:0002523;GO:0046903;GO:0042330;GO:0071345;GO:0050896;GO:0001775;GO:2000145;GO:0002690;GO:2000147;GO:0002263;GO:0032103;GO:0032101;GO:0023052;GO:0070887;GO:0044699;GO:0002446;GO:0097530;GO:0040011;GO:0032501;GO:0050878;GO:0008283;GO:0009987;GO:0051270;GO:0098542;GO:0032879;GO:0055085;GO:0032940;GO:0002237;GO:0097529;GO:0070098;GO:0042119;GO:1990266;GO:0043312;GO:0050900;GO:0051302;GO:0051301;GO:0033993;GO:0002576;GO:0015758;GO:0071310;GO:0043299;GO:0071702;GO:0071621;GO:0030335;GO:0030334;GO:0044765;GO:0044763;GO:0042221;GO:0002443;GO:0002444;GO:0051179;GO:1902578;GO:1901700;GO:0051272;GO:0040012;GO:0040017;GO:0015749;GO:0002252;GO:0036230;GO:0048522;GO:0016192; hemostasis;cytokine-mediated signaling pathway;blood coagulation;regulation of response to stimulus;regulation of chemotaxis;signal transduction;cell surface receptor signaling pathway;cell chemotaxis;carbohydrate transport;carbohydrate transmembrane transport;cellular response to stimulus;response to external biotic stimulus;response to bacterium;response to wounding;regulation of leukocyte migration;positive regulation of biological process;regulation of immune system process;regulation of cell proliferation;leukocyte chemotaxis;positive regulation of response to stimulus;neutrophil chemotaxis;chemotaxis;response to other organism;response to organic substance;platelet activation;multi-organism process;single organism signaling;cell migration;response to biotic stimulus;single-multicellular organism process;response to external stimulus;myeloid cell activation involved in immune response;cell motility;immune system process;cell communication;myeloid leukocyte activation;positive regulation of chemotaxis;movement of cell or subcellular component;leukocyte activation;localization of cell;defense response to bacterium;response to lipopolysaccharide;regulation of biological process;neutrophil activation involved in immune response;hexose transport;exocytosis;positive regulation of cell division;regulated exocytosis;positive regulation of leukocyte migration;positive regulation of immune system process;leukocyte activation involved in immune response;biological regulation;glucose transmembrane transport;regulation of biological quality;G-protein coupled receptor signaling pathway;regulation of leukocyte chemotaxis;hexose transmembrane transport;response to cytokine;transport;wound healing;regulation of cellular process;defense response;response to stress;coagulation;biological_process;inflammatory response;immune response;establishment of localization;leukocyte migration involved in inflammatory response;secretion;taxis;cellular response to cytokine stimulus;response to stimulus;cell activation;regulation of cell motility;positive regulation of leukocyte chemotaxis;positive regulation of cell motility;cell activation involved in immune response;positive regulation of response to external stimulus;regulation of response to external stimulus;signaling;cellular response to chemical stimulus;single-organism process;neutrophil mediated immunity;granulocyte migration;locomotion;multicellular organismal process;regulation of body fluid levels;cell proliferation;cellular process;regulation of cellular component movement;defense response to other organism;regulation of localization;transmembrane transport;secretion by cell;response to molecule of bacterial origin;myeloid leukocyte migration;chemokine-mediated signaling pathway;neutrophil activation;neutrophil migration;neutrophil degranulation;leukocyte migration;regulation of cell division;cell division;response to lipid;platelet degranulation;glucose transport;cellular response to organic substance;leukocyte degranulation;organic substance transport;granulocyte chemotaxis;positive regulation of cell migration;regulation of cell migration;single-organism transport;single-organism cellular process;response to chemical;leukocyte mediated immunity;myeloid leukocyte mediated immunity;localization;single-organism localization;response to oxygen-containing compound;positive regulation of cellular component movement;regulation of locomotion;positive regulation of locomotion;monosaccharide transport;immune effector process;granulocyte activation;positive regulation of cellular process;vesicle-mediated transport; 5;6;5;3;4;4;5;5;5;5;3;4;4;4;4;2;3;4;4;3;6;4;3;4;5;2;3;4;3;3;3;5;3;2;4;4;4;4;3;3;5;5;2;4;7;5;4;6;4;3;4;2;7;3;5;5;6;5;4;5;3;4;3;4;1;5;3;3;4;5;3;6;2;4;4;5;4;4;4;4;2;4;2;6;5;2;2;4;3;2;4;4;3;4;4;5;4;7;6;6;5;3;4;4;5;7;8;5;4;5;5;5;5;4;3;3;4;5;2;3;4;4;3;3;6;3;5;3;5; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0099503;GO:0034774;GO:0043233;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044433;GO:0030141;GO:0097708;GO:0044446;GO:0044444;GO:0012505;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0005615;GO:0043226;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;secretory vesicle;secretory granule lumen;organelle lumen;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;secretory granule;intracellular vesicle;intracellular organelle part;cytoplasmic part;endomembrane system;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;intracellular;extracellular space;organelle;cellular_component;extracellular region; 2;4;4;5;5;6;5;3;4;3;2;2;3;3;4;4;4;3;4;3;5;4;5;6;5;2;2;3;3;2;1;2; GO:0015149;GO:0051119;GO:0015145;GO:0005126;GO:0005125;GO:0008009;GO:0003674;GO:1901476;GO:0015144;GO:0045236;GO:0022891;GO:0022892;GO:0001664;GO:0042379;GO:0005355;GO:0005215;GO:0005515;GO:0005102;GO:0005488;GO:0022857; hexose transmembrane transporter activity;sugar transmembrane transporter activity;monosaccharide transmembrane transporter activity;cytokine receptor binding;cytokine activity;chemokine activity;molecular_function;carbohydrate transporter activity;carbohydrate transmembrane transporter activity;CXCR chemokine receptor binding;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;G-protein coupled receptor binding;chemokine receptor binding;glucose transmembrane transporter activity;transporter activity;protein binding;receptor binding;binding;transmembrane transporter activity; 7;5;6;5;5;6;1;3;4;7;4;3;5;6;8;2;3;4;2;3; K10029 map04060;map04062; Cytokine-cytokine receptor interaction;Chemokine signaling pathway; IPR001089;IPR027223;IPR001811;IPR033899;IPR018048; CXC chemokine;Platelet basic protein;Chemokine interleukin-8-like domain;CXC Chemokine domain;CXC chemokine, conserved site; extracellular Q9NUL3 Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2 - [STAU2_HUMAN] 0.907 0.877 1.851 0.817 0.678 0.488 1.034207526 nan 1.205014749 nan 2.110604333 nan 0.719764012 nan GO:0006810;GO:0008150;GO:0051234;GO:0051179; transport;biological_process;establishment of localization;localization; 4;1;3;2; GO:0099512;GO:0005783;GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0099513;GO:0005737;GO:0005575;GO:0031981;GO:0005730;GO:0005874;GO:0005634;GO:0016020;GO:0044430;GO:0005856;GO:0015630;GO:0012505;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422; supramolecular fiber;endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;polymeric cytoskeletal fiber;cytoplasm;cellular_component;nuclear lumen;nucleolus;microtubule;nucleus;membrane;cytoskeletal part;cytoskeleton;microtubule cytoskeleton;endomembrane system;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part; 2;4;2;3;3;3;2;3;4;1;5;5;4;5;2;4;5;6;3;4;4;3;2;2;3;3;4;4;4;3;2; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0044822;GO:0097159;GO:0003725;GO:0003723; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;poly(A) RNA binding;organic cyclic compound binding;double-stranded RNA binding;RNA binding; 1;2;4;3;6;3;6;5; K17597 IPR014720;IPR032478; Double-stranded RNA-binding domain;Staufen, C-terminal; nucleus Hs7657625 966.0 UK [U] Intracellular trafficking, secretion, and vesicular transport;[K] Transcription; A2RUG3 Testis-specific XK-related protein, Y-linked 2 OS=Homo sapiens OX=9606 GN=XKRY2 PE=2 SV=2 - [XKRY2_HUMAN] 1.453 0.847 1.038 1.107 0.803 0.705 1.715466352 nan 1.378580324 nan 1.225501771 nan 0.877957659 nan GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; IPR018629; XK-related protein; plasma membrane Q14123 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C OS=Homo sapiens OX=9606 GN=PDE1C PE=1 SV=1 - [PDE1C_HUMAN] 1.005 0.874 1.311 1.081 0.713 1.534 1.149885584 nan 1.516129032 nan 1.5 nan 2.151472651 nan GO:0007173;GO:0060193;GO:0060191;GO:0070887;GO:0002376;GO:0044344;GO:0038127;GO:0007166;GO:0007167;GO:0007169;GO:0010863;GO:0008543;GO:0050789;GO:0043085;GO:0051716;GO:0051345;GO:0070848;GO:0071310;GO:0065007;GO:0044699;GO:0044093;GO:0065009;GO:0071495;GO:0009987;GO:0038179;GO:0045087;GO:0050790;GO:0071774;GO:0050794;GO:0006952;GO:0042221;GO:0008150;GO:0023052;GO:0006955;GO:0048011;GO:0007154;GO:0010033;GO:0051336;GO:0044700;GO:1900274;GO:0071363;GO:0007202;GO:0006950;GO:0010518;GO:0044763;GO:0009719;GO:0050896;GO:0010517;GO:0007165; epidermal growth factor receptor signaling pathway;positive regulation of lipase activity;regulation of lipase activity;cellular response to chemical stimulus;immune system process;cellular response to fibroblast growth factor stimulus;ERBB signaling pathway;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of phospholipase C activity;fibroblast growth factor receptor signaling pathway;regulation of biological process;positive regulation of catalytic activity;cellular response to stimulus;positive regulation of hydrolase activity;response to growth factor;cellular response to organic substance;biological regulation;single-organism process;positive regulation of molecular function;regulation of molecular function;cellular response to endogenous stimulus;cellular process;neurotrophin signaling pathway;innate immune response;regulation of catalytic activity;response to fibroblast growth factor;regulation of cellular process;defense response;response to chemical;biological_process;signaling;immune response;neurotrophin TRK receptor signaling pathway;cell communication;response to organic substance;regulation of hydrolase activity;single organism signaling;regulation of phospholipase C activity;cellular response to growth factor stimulus;activation of phospholipase C activity;response to stress;positive regulation of phospholipase activity;single-organism cellular process;response to endogenous stimulus;response to stimulus;regulation of phospholipase activity;signal transduction; 9;7;6;4;2;5;8;5;6;7;9;6;2;5;3;6;5;5;2;2;4;3;4;2;6;4;4;4;3;4;3;1;2;3;7;4;4;5;3;8;6;10;3;8;3;3;2;7;4; GO:0005737;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; cytoplasm;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 4;5;2;2;3;1;4;3; GO:0004114;GO:0004117;GO:0004112;GO:0042578;GO:0003674;GO:0043169;GO:0008081;GO:0043167;GO:0046872;GO:0016787;GO:0005488;GO:0016788;GO:0003824; 3',5'-cyclic-nucleotide phosphodiesterase activity;calmodulin-dependent cyclic-nucleotide phosphodiesterase activity;cyclic-nucleotide phosphodiesterase activity;phosphoric ester hydrolase activity;molecular_function;cation binding;phosphoric diester hydrolase activity;ion binding;metal ion binding;hydrolase activity;binding;hydrolase activity, acting on ester bonds;catalytic activity; 8;9;7;5;1;4;6;3;5;3;2;4;2; K13755 map00230;map04020;map04740;map04742;map04924;map05032; Purine metabolism;Calcium signaling pathway;Olfactory transduction;Taste transduction;Renin secretion;Morphine addiction; IPR023174;IPR023088;IPR003607;IPR002073;IPR013706; 3'5'-cyclic nucleotide phosphodiesterase, conserved site;3'5'-cyclic nucleotide phosphodiesterase;HD/PDEase domain;3'5'-cyclic nucleotide phosphodiesterase, catalytic domain;3'5'-cyclic nucleotide phosphodiesterase N-terminal; cytosol Hs4826894 1310.0 T [T] Signal transduction mechanisms; P01817 Immunoglobulin heavy variable 2-5 OS=Homo sapiens OX=9606 GN=IGHV2-5 PE=1 SV=2 - [HV205_HUMAN] 1.074 0.915 1.211 0.877 0.984 0.697 1.173770492 0.035252239 0.891260163 0.706771216 1.323497268 0.001874708 0.708333333 0.001969437 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q86YH6 Decaprenyl-diphosphate synthase subunit 2 OS=Homo sapiens OX=9606 GN=PDSS2 PE=1 SV=2 - [DLP1_HUMAN] 0.851 1.265 0.779 0.95 1.501 0.671 0.672727273 nan 0.632911392 nan 0.615810277 nan 0.44703531 nan GO:0022607;GO:0070271;GO:0006732;GO:0006733;GO:0044249;GO:0043933;GO:0044281;GO:0044283;GO:0044699;GO:0016043;GO:1901576;GO:0044710;GO:0051186;GO:0071822;GO:0071704;GO:1901663;GO:0051188;GO:1901661;GO:0065003;GO:0065007;GO:0071840;GO:0065008;GO:0006743;GO:0006461;GO:0006629;GO:0050878;GO:0006720;GO:0009987;GO:0051291;GO:0051290;GO:0009058;GO:0044711;GO:0008150;GO:0008152;GO:0008610;GO:0044255;GO:0042180;GO:0051259;GO:0044238;GO:0006744;GO:0042181;GO:0051262;GO:0044763;GO:0008299;GO:0044085;GO:0009108;GO:0044237; cellular component assembly;protein complex biogenesis;coenzyme metabolic process;oxidoreduction coenzyme metabolic process;cellular biosynthetic process;macromolecular complex subunit organization;small molecule metabolic process;small molecule biosynthetic process;single-organism process;cellular component organization;organic substance biosynthetic process;single-organism metabolic process;cofactor metabolic process;protein complex subunit organization;organic substance metabolic process;quinone biosynthetic process;cofactor biosynthetic process;quinone metabolic process;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;regulation of biological quality;ubiquinone metabolic process;protein complex assembly;lipid metabolic process;regulation of body fluid levels;isoprenoid metabolic process;cellular process;protein heterooligomerization;protein heterotetramerization;biosynthetic process;single-organism biosynthetic process;biological_process;metabolic process;lipid biosynthetic process;cellular lipid metabolic process;cellular ketone metabolic process;protein oligomerization;primary metabolic process;ubiquinone biosynthetic process;ketone biosynthetic process;protein tetramerization;single-organism cellular process;isoprenoid biosynthetic process;cellular component biogenesis;coenzyme biosynthetic process;cellular metabolic process; 4;4;5;6;4;4;4;5;2;3;4;3;4;5;3;6;5;5;5;2;2;3;6;5;4;4;5;2;7;8;3;4;1;2;5;4;4;6;3;7;5;7;3;5;3;6;3; GO:0043231;GO:1990234;GO:0070013;GO:0031974;GO:0005739;GO:1902494;GO:0043227;GO:0043226;GO:0005737;GO:0005759;GO:0044446;GO:0043234;GO:0032991;GO:0044444;GO:0043233;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044429;GO:0044424;GO:0044422; intracellular membrane-bounded organelle;transferase complex;intracellular organelle lumen;membrane-enclosed lumen;mitochondrion;catalytic complex;membrane-bounded organelle;organelle;cytoplasm;mitochondrial matrix;intracellular organelle part;protein complex;macromolecular complex;cytoplasmic part;organelle lumen;cell part;intracellular organelle;cell;intracellular;cellular_component;mitochondrial part;intracellular part;organelle part; 4;5;4;2;5;4;3;2;4;5;3;3;2;4;3;2;3;2;3;1;4;3;2; GO:0003674;GO:0046983;GO:0016765;GO:0016740;GO:0046982;GO:0003824;GO:0000010;GO:0005515;GO:0050347;GO:0005488; molecular_function;protein dimerization activity;transferase activity, transferring alkyl or aryl (other than methyl) groups;transferase activity;protein heterodimerization activity;catalytic activity;trans-hexaprenyltranstransferase activity;protein binding;trans-octaprenyltranstransferase activity;binding; 1;4;4;3;5;2;5;3;5;2; K12505 map00900;map01110; Terpenoid backbone biosynthesis;Biosynthesis of secondary metabolites; IPR000092;IPR008949; Polyprenyl synthetase;Isoprenoid synthase domain; mitochondria Hs9966853 821.0 H [H] Coenzyme transport and metabolism; Q58DX5 Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 OS=Homo sapiens OX=9606 GN=NAALADL2 PE=1 SV=3 - [NADL2_HUMAN] 1.108 1.018 1.123 1.203 1.032 nan 1.088408644 nan 1.165697674 nan 1.103143418 nan nan nan GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; K01301 IPR007484;IPR007365; Peptidase M28;Transferrin receptor-like, dimerisation domain; plasma membrane Hs20470304 389.0 OPR [O] Posttranslational modification, protein turnover, chaperones;[P] Inorganic ion transport and metabolism;[R] General function prediction only; P10114 Ras-related protein Rap-2a OS=Homo sapiens OX=9606 GN=RAP2A PE=1 SV=1 - [RAP2A_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0043408;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0048468;GO:0016358;GO:0061024;GO:0007009;GO:0007165;GO:0009966;GO:0030182;GO:0032989;GO:0031344;GO:0071840;GO:0051716;GO:0010604;GO:0070727;GO:0048869;GO:0010256;GO:0045664;GO:0048518;GO:0065007;GO:0033036;GO:0051403;GO:0048699;GO:0060255;GO:0042493;GO:0042327;GO:0045184;GO:0072657;GO:0010975;GO:0072659;GO:0042325;GO:0044700;GO:0044707;GO:0048870;GO:0019538;GO:0000165;GO:0033554;GO:0022604;GO:0022607;GO:0009893;GO:0022603;GO:0031954;GO:0023051;GO:0031952;GO:0006928;GO:0051674;GO:0031175;GO:0046328;GO:0035556;GO:0043170;GO:0050789;GO:0044267;GO:0009653;GO:0000902;GO:0045937;GO:0044260;GO:0010646;GO:0016043;GO:0023014;GO:0016477;GO:0031098;GO:0050793;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051234;GO:0044767;GO:0050896;GO:0031401;GO:0006950;GO:0048812;GO:2000145;GO:0048814;GO:2000146;GO:0044802;GO:0032486;GO:0016310;GO:0030154;GO:0051128;GO:0023052;GO:0070887;GO:0007154;GO:1990778;GO:0046777;GO:0044699;GO:0050767;GO:0007254;GO:1902531;GO:0010562;GO:0051246;GO:0051247;GO:0060284;GO:0022008;GO:0010769;GO:0032270;GO:0031399;GO:0032502;GO:0040011;GO:0032501;GO:0070302;GO:0009987;GO:0051271;GO:0048583;GO:0032872;GO:0045595;GO:0040012;GO:0048667;GO:0048519;GO:0032879;GO:0048858;GO:0032268;GO:0050773;GO:0048813;GO:0051239;GO:0048731;GO:0080134;GO:0080135;GO:0030030;GO:0030031;GO:0031325;GO:0030033;GO:0031323;GO:0030036;GO:0035690;GO:0007275;GO:1902580;GO:0031532;GO:0006796;GO:0071704;GO:0051960;GO:0048666;GO:0030336;GO:0006468;GO:0030334;GO:0030029;GO:0034613;GO:0032528;GO:0006464;GO:0051174;GO:0000904;GO:0044763;GO:0042221;GO:0007265;GO:0007264;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0040013;GO:0051270;GO:0007010;GO:0032990;GO:0007399;GO:0048856;GO:0044237;GO:1902589;GO:0044085;GO:2000026;GO:0006793;GO:0001932;GO:0001934;GO:0048523;GO:0048522; regulation of MAPK cascade;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;cell development;dendrite development;membrane organization;plasma membrane organization;signal transduction;regulation of signal transduction;neuron differentiation;cellular component morphogenesis;regulation of cell projection organization;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of macromolecule metabolic process;cellular macromolecule localization;cellular developmental process;endomembrane system organization;regulation of neuron differentiation;positive regulation of biological process;biological regulation;macromolecule localization;stress-activated MAPK cascade;generation of neurons;regulation of macromolecule metabolic process;response to drug;positive regulation of phosphorylation;establishment of protein localization;protein localization to membrane;regulation of neuron projection development;protein localization to plasma membrane;regulation of phosphorylation;single organism signaling;single-multicellular organism process;cell motility;protein metabolic process;MAPK cascade;cellular response to stress;regulation of cell morphogenesis;cellular component assembly;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;positive regulation of protein autophosphorylation;regulation of signaling;regulation of protein autophosphorylation;movement of cell or subcellular component;localization of cell;neuron projection development;regulation of JNK cascade;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;anatomical structure morphogenesis;cell morphogenesis;positive regulation of phosphate metabolic process;cellular macromolecule metabolic process;regulation of cell communication;cellular component organization;signal transduction by protein phosphorylation;cell migration;stress-activated protein kinase signaling cascade;regulation of developmental process;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of localization;single-organism developmental process;response to stimulus;positive regulation of protein modification process;response to stress;neuron projection morphogenesis;regulation of cell motility;regulation of dendrite morphogenesis;negative regulation of cell motility;single-organism membrane organization;Rap protein signal transduction;phosphorylation;cell differentiation;regulation of cellular component organization;signaling;cellular response to chemical stimulus;cell communication;protein localization to cell periphery;protein autophosphorylation;single-organism process;regulation of neurogenesis;JNK cascade;regulation of intracellular signal transduction;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell development;neurogenesis;regulation of cell morphogenesis involved in differentiation;positive regulation of cellular protein metabolic process;regulation of protein modification process;developmental process;locomotion;multicellular organismal process;regulation of stress-activated protein kinase signaling cascade;cellular process;negative regulation of cellular component movement;regulation of response to stimulus;regulation of stress-activated MAPK cascade;regulation of cell differentiation;regulation of locomotion;cell morphogenesis involved in neuron differentiation;negative regulation of biological process;regulation of localization;cell projection morphogenesis;regulation of cellular protein metabolic process;regulation of dendrite development;dendrite morphogenesis;regulation of multicellular organismal process;system development;regulation of response to stress;regulation of cellular response to stress;cell projection organization;cell projection assembly;positive regulation of cellular metabolic process;microvillus assembly;regulation of cellular metabolic process;actin cytoskeleton organization;cellular response to drug;multicellular organism development;single-organism cellular localization;actin cytoskeleton reorganization;phosphate-containing compound metabolic process;organic substance metabolic process;regulation of nervous system development;neuron development;negative regulation of cell migration;protein phosphorylation;regulation of cell migration;actin filament-based process;cellular protein localization;microvillus organization;cellular protein modification process;regulation of phosphorus metabolic process;cell morphogenesis involved in differentiation;single-organism cellular process;response to chemical;Ras protein signal transduction;small GTPase mediated signal transduction;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;negative regulation of locomotion;regulation of cellular component movement;cytoskeleton organization;cell part morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;regulation of multicellular organismal development;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;6;4;3;4;4;4;5;4;4;6;4;5;2;3;4;4;4;4;7;2;2;3;6;7;4;4;7;4;5;6;6;7;3;3;3;4;5;4;5;4;3;4;8;3;8;4;3;5;7;5;4;2;5;3;5;6;4;4;3;4;4;5;3;3;3;5;5;1;2;3;3;2;6;3;6;4;6;4;4;8;6;5;4;2;4;4;6;8;2;6;7;5;5;5;5;5;6;6;5;6;2;2;2;5;2;4;3;6;4;3;6;2;3;5;5;5;5;3;4;4;4;4;5;4;6;4;5;5;4;4;6;5;3;5;5;5;7;5;4;5;5;6;5;5;3;3;7;6;2;3;3;4;3;3;4;5;5;5;3;3;4;3;4;4;7;7;3;3; GO:0005773;GO:0016020;GO:0005774;GO:0005576;GO:0098588;GO:0043230;GO:0043231;GO:0005829;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0043229;GO:0043227;GO:1903561;GO:0044437;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0044440;GO:0055038;GO:0055037;GO:0010008;GO:0005737;GO:0031090;GO:0030496;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0098805;GO:0043226;GO:0005886;GO:0005575;GO:0005768; vacuole;membrane;vacuolar membrane;extracellular region;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;cytosol;intracellular part;extracellular region part;organelle part;cell part;intracellular organelle;membrane-bounded organelle;extracellular vesicle;vacuolar part;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;endosomal part;recycling endosome membrane;recycling endosome;endosome membrane;cytoplasm;organelle membrane;midbody;cell;intracellular;cell periphery;extracellular exosome;whole membrane;organelle;plasma membrane;cellular_component;endosome; 5;2;4;2;4;3;4;5;3;2;2;2;3;3;3;4;3;4;3;4;5;6;5;5;4;3;3;2;3;3;4;3;2;3;1;4; GO:0003924;GO:0016818;GO:0016817;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005525;GO:0016787;GO:0000166;GO:0003824;GO:0097159;GO:0016462;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0032561;GO:0036094;GO:0001883;GO:0019001;GO:0001882;GO:0017111;GO:0043168; GTPase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;hydrolase activity, acting on acid anhydrides;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;GTP binding;hydrolase activity;nucleotide binding;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;guanyl ribonucleotide binding;small molecule binding;purine nucleoside binding;guanyl nucleotide binding;nucleoside binding;nucleoside-triphosphatase activity;anion binding; 8;5;4;3;1;2;4;3;5;5;6;3;4;2;3;6;5;6;4;5;3;6;3;5;6;4;7;4; K07837 IPR001806;IPR005225;IPR020849;IPR027417; Small GTPase superfamily;Small GTP-binding protein domain;Small GTPase superfamily, Ras type;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs10518344 377.0 R [R] General function prediction only; P13682 Zinc finger protein 35 OS=Homo sapiens OX=9606 GN=ZNF35 PE=1 SV=4 - [ZNF35_HUMAN] 1.193 1.105 0.721 1.173 1.206 0.559 1.079638009 nan 0.972636816 nan 0.652488688 nan 0.463515755 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0051716;GO:0000003;GO:0010467;GO:0051704;GO:0060255;GO:0007283;GO:2001141;GO:0010033;GO:0046483;GO:0044703;GO:0044702;GO:0019438;GO:0070887;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0019953;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0032501;GO:0048609;GO:0032504;GO:0044238;GO:0009987;GO:0006725;GO:1903506;GO:0001101;GO:0048232;GO:0051252;GO:0031326;GO:0031323;GO:0071229;GO:0090304;GO:0007276;GO:0033993;GO:2000112;GO:0071704;GO:0071310;GO:0010468;GO:0032526;GO:0019219;GO:0071396;GO:0022414;GO:0009058;GO:0009059;GO:0051171;GO:0042221;GO:1901700;GO:1901701;GO:0044237;GO:0071300; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;reproduction;gene expression;multi-organism process;regulation of macromolecule metabolic process;spermatogenesis;regulation of RNA biosynthetic process;response to organic substance;heterocycle metabolic process;multi-organism reproductive process;single organism reproductive process;aromatic compound biosynthetic process;cellular response to chemical stimulus;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;sexual reproduction;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;primary metabolic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;response to acid chemical;male gamete generation;regulation of RNA metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;cellular response to acid chemical;nucleic acid metabolic process;gamete generation;response to lipid;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;regulation of gene expression;response to retinoic acid;regulation of nucleobase-containing compound metabolic process;cellular response to lipid;reproductive process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;response to chemical;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular metabolic process;cellular response to retinoic acid; 4;3;5;4;3;2;5;2;4;6;6;4;4;3;3;5;4;3;4;2;7;4;4;2;5;4;3;1;2;5;5;5;2;6;5;6;6;3;4;4;5;2;4;2;3;3;3;2;4;7;4;5;5;5;4;5;5;4;5;6;3;5;5;5;5;6;2;3;5;4;3;4;5;3;6; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0048471;GO:0044444;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;perinuclear region of cytoplasm;cytoplasmic part;cytoplasm;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;4;4;5;2;2;3;2;1; GO:0043169;GO:0001071;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043565;GO:0097159;GO:0043167;GO:0046872;GO:0003700; cation binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;sequence-specific DNA binding;organic cyclic compound binding;ion binding;metal ion binding;transcription factor activity, sequence-specific DNA binding; 4;2;3;1;2;4;5;6;3;3;5;3; IPR013087;IPR013083; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type; nucleus Hs21361561 1071.0 R [R] General function prediction only; Q5T8I3 Protein FAM102B OS=Homo sapiens OX=9606 GN=FAM102B PE=1 SV=2 - [F102B_HUMAN] 0.902 0.985 1.068 0.811 1.19 1.675 0.915736041 nan 0.681512605 nan 1.084263959 nan 1.407563025 nan IPR019448; EEIG1/EHBP1 N-terminal domain; nucleus 7298776 189.0 S [S] Function unknown; Q14764 Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4 - [MVP_HUMAN] 1.074 1.166 0.787 1.17 1.097 0.913 0.92109777 nan 1.066545123 nan 0.674957118 nan 0.832269827 nan GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0051716;GO:0010605;GO:0018212;GO:0018193;GO:0044092;GO:0048519;GO:0033036;GO:0060255;GO:0045859;GO:0045184;GO:0042325;GO:0044700;GO:0042326;GO:0019538;GO:0050730;GO:0050732;GO:0033673;GO:0009892;GO:0031952;GO:0031953;GO:0051028;GO:0043170;GO:0044267;GO:0044260;GO:0043549;GO:0046777;GO:0065007;GO:0061097;GO:0061099;GO:0065009;GO:0050790;GO:0006810;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051236;GO:0051234;GO:0050658;GO:0050896;GO:0050657;GO:0051338;GO:0015931;GO:0010563;GO:0016310;GO:0023057;GO:0023052;GO:0038127;GO:0023051;GO:0043086;GO:0044699;GO:0051248;GO:0051246;GO:0031399;GO:0044238;GO:0009987;GO:0051348;GO:0032269;GO:0032268;GO:0031400;GO:0031324;GO:0031323;GO:0018108;GO:0050789;GO:0071705;GO:0071704;GO:0071702;GO:0006403;GO:0006468;GO:0006469;GO:0045936;GO:0006464;GO:0051174;GO:0044763;GO:0007154;GO:0051179;GO:0044237;GO:0006796;GO:0006793;GO:0015031;GO:0001933;GO:0001932;GO:0048523; protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;peptidyl-tyrosine modification;peptidyl-amino acid modification;negative regulation of molecular function;negative regulation of biological process;macromolecule localization;regulation of macromolecule metabolic process;regulation of protein kinase activity;establishment of protein localization;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;negative regulation of peptidyl-tyrosine phosphorylation;negative regulation of kinase activity;negative regulation of metabolic process;regulation of protein autophosphorylation;negative regulation of protein autophosphorylation;mRNA transport;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;protein autophosphorylation;biological regulation;regulation of protein tyrosine kinase activity;negative regulation of protein tyrosine kinase activity;regulation of molecular function;regulation of catalytic activity;transport;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;establishment of RNA localization;establishment of localization;RNA transport;response to stimulus;nucleic acid transport;regulation of transferase activity;nucleobase-containing compound transport;negative regulation of phosphorus metabolic process;phosphorylation;negative regulation of signaling;signaling;ERBB signaling pathway;regulation of signaling;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;regulation of protein metabolic process;regulation of protein modification process;primary metabolic process;cellular process;negative regulation of transferase activity;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;negative regulation of protein modification process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;regulation of biological process;nitrogen compound transport;organic substance metabolic process;organic substance transport;RNA localization;protein phosphorylation;negative regulation of protein kinase activity;negative regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;cell communication;localization;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;protein transport;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process; 4;6;4;3;4;5;6;7;3;4;8;7;4;2;3;4;7;4;7;3;7;4;8;8;7;3;8;8;6;4;5;4;6;8;2;8;9;3;4;4;3;5;5;1;2;4;3;5;2;7;5;6;5;6;3;2;8;3;5;2;5;5;6;3;2;6;5;5;6;4;4;8;2;5;3;5;4;7;8;6;6;5;3;4;2;3;5;4;5;7;7;3; GO:0031975;GO:0030529;GO:0031982;GO:0016020;GO:0031967;GO:0048471;GO:0043230;GO:0043231;GO:0043232;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0012505;GO:0005643;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005635;GO:1990904;GO:0005623;GO:0005622;GO:0070062;GO:1903561;GO:0032991;GO:0005575;GO:0005576; envelope;intracellular ribonucleoprotein complex;vesicle;membrane;organelle envelope;perinuclear region of cytoplasm;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;nuclear part;intracellular part;extracellular region part;organelle part;cell part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;endomembrane system;nuclear pore;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;nuclear envelope;ribonucleoprotein complex;cell;intracellular;extracellular exosome;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 3;4;4;2;4;5;3;4;4;4;3;2;2;2;3;3;3;2;5;3;5;3;4;4;5;4;3;2;3;4;3;2;1;2; GO:0019900;GO:0019903;GO:0019902;GO:0003674;GO:0005488;GO:0019899;GO:0005515;GO:0019901; kinase binding;protein phosphatase binding;phosphatase binding;molecular_function;binding;enzyme binding;protein binding;protein kinase binding; 5;6;5;1;2;4;3;6; K17266 IPR002499;IPR021870; Major vault protein, N-terminal;Major vault protein, shoulder domain; cytosol 428309882 874.0 S [S] Function unknown; COG2268 Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain Q5T1B0 Axonemal dynein light chain domain-containing protein 1 OS=Homo sapiens OX=9606 GN=AXDND1 PE=2 SV=1 - [AXDN1_HUMAN] 1.194 1.166 0.734 1.159 0.968 1.165 1.024013722 nan 1.19731405 nan 0.629502573 nan 1.203512397 nan IPR019347; Axonemal dynein light chain; nucleus Q15848 Adiponectin OS=Homo sapiens OX=9606 GN=ADIPOQ PE=1 SV=1 - [ADIPO_HUMAN] 1.02 0.997 0.983 1.132 1.105 0.96 1.023069208 0.863689574 1.024434389 0.671555625 0.985957874 0.582983479 0.868778281 0.667281482 GO:0033157;GO:0006909;GO:0051046;GO:0030225;GO:0051049;GO:0044281;GO:0044282;GO:0044283;GO:0072298;GO:0019221;GO:0051716;GO:0070371;GO:0001666;GO:0018212;GO:0030852;GO:0030853;GO:0030851;GO:0030856;GO:0030855;GO:0071605;GO:0030858;GO:0032386;GO:0032387;GO:0048468;GO:0045859;GO:0051291;GO:0046483;GO:0042325;GO:0042327;GO:0042326;GO:0009605;GO:0034284;GO:0019538;GO:0070542;GO:0070543;GO:0009892;GO:0009893;GO:0032799;GO:0031952;GO:0031953;GO:0010906;GO:0043393;GO:0071867;GO:0071868;GO:0071902;GO:0035556;GO:0071900;GO:0051224;GO:0050789;GO:0032091;GO:0051347;GO:0008645;GO:0006886;GO:0051348;GO:0008643;GO:0002682;GO:0002683;GO:0006111;GO:0045912;GO:0018130;GO:0070201;GO:0098602;GO:0007623;GO:0070206;GO:0098609;GO:0009889;GO:2000279;GO:2000278;GO:0090193;GO:0009888;GO:0043412;GO:0060761;GO:0019395;GO:0002521;GO:0002520;GO:0016070;GO:0071345;GO:0010556;GO:0048545;GO:0048869;GO:0044802;GO:0097305;GO:0010558;GO:0071871;GO:0000165;GO:0033209;GO:0051129;GO:0051128;GO:1903827;GO:0014074;GO:0014070;GO:1903828;GO:0060284;GO:0070293;GO:0008285;GO:0008283;GO:0050873;GO:0043124;GO:0046883;GO:0010675;GO:0001656;GO:0010677;GO:0046888;GO:0044255;GO:0030258;GO:0006979;GO:0042593;GO:0032720;GO:0034383;GO:0045923;GO:0060341;GO:0018108;GO:0042592;GO:0022407;GO:0010827;GO:0035690;GO:0008217;GO:0045444;GO:0008219;GO:0010828;GO:0022408;GO:0006094;GO:0033993;GO:0072202;GO:2000112;GO:2000113;GO:0072207;GO:0007275;GO:0043065;GO:0043067;GO:0046683;GO:0048598;GO:0006468;GO:0006469;GO:0019217;GO:0019216;GO:0019219;GO:0006461;GO:0090317;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0030100;GO:0006091;GO:1901700;GO:1901701;GO:0040013;GO:0040012;GO:0006109;GO:0048856;GO:0009914;GO:1902106;GO:0006796;GO:2000026;GO:0006793;GO:0043112;GO:0032757;GO:0048523;GO:0048522;GO:0034440;GO:0034115;GO:0034114;GO:0034113;GO:0031348;GO:0007162;GO:0003013;GO:0003014;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0031347;GO:0044712;GO:0050728;GO:0044711;GO:0007369;GO:0010256;GO:0050727;GO:0044093;GO:0044092;GO:0033034;GO:0033036;GO:0002064;GO:0033032;GO:0051053;GO:0051052;GO:0051051;GO:0051050;GO:0071375;GO:2001141;GO:0050804;GO:1903706;GO:1903707;GO:0098742;GO:0044248;GO:0009790;GO:0031667;GO:0043068;GO:0050731;GO:0045713;GO:0045715;GO:0045714;GO:1903530;GO:0015918;GO:0015850;GO:0061005;GO:0046323;GO:0006807;GO:0046324;GO:0035790;GO:0046326;GO:0044242;GO:0072224;GO:0002761;GO:0044267;GO:0009653;GO:0044262;GO:0044260;GO:0070994;GO:0072249;GO:0072248;GO:0010640;GO:0070271;GO:0061318;GO:0043409;GO:0032880;GO:0007584;GO:0006915;GO:2000467;GO:2000465;GO:0050793;GO:0050790;GO:0019318;GO:0019319;GO:0050794;GO:0072300;GO:0071872;GO:0051239;GO:0071870;GO:0097006;GO:0051234;GO:1902679;GO:0006897;GO:0032368;GO:0046395;GO:0050896;GO:0034381;GO:0051338;GO:2000145;GO:0097017;GO:2000146;GO:0097018;GO:0033674;GO:0051240;GO:0006631;GO:0051241;GO:0032102;GO:0006635;GO:0032101;GO:0010565;GO:0043407;GO:0043405;GO:1903531;GO:0060759;GO:0070887;GO:1990778;GO:0044699;GO:0043408;GO:0072015;GO:0051248;GO:0050765;GO:0072010;GO:0009890;GO:0044057;GO:0010562;GO:0010563;GO:0051246;GO:0051247;GO:0031399;GO:0032677;GO:1903034;GO:1903035;GO:0033211;GO:0040011;GO:0014912;GO:0051271;GO:0051270;GO:0014812;GO:0010869;GO:0048731;GO:0070373;GO:0070372;GO:0071897;GO:0051384;GO:0016337;GO:0072217;GO:0043933;GO:0046364;GO:0071869;GO:0071901;GO:0051223;GO:0042981;GO:1901360;GO:1902105;GO:0072215;GO:0045934;GO:0045937;GO:0045936;GO:0010817;GO:0045471;GO:0007268;GO:0007267;GO:0042221;GO:0070482;GO:0009746;GO:0044238;GO:0009744;GO:0005975;GO:0009743;GO:0044237;GO:0009749;GO:0006259;GO:0045806;GO:0019220;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0008104;GO:0060081;GO:1901362;GO:0071840;GO:0009968;GO:0009966;GO:0009967;GO:0001822;GO:0046879;GO:0048511;GO:0048513;GO:0010720;GO:0048518;GO:0048519;GO:0032722;GO:0043122;GO:0043123;GO:0042127;GO:0042493;GO:0045184;GO:0032869;GO:0072657;GO:0043436;GO:0043434;GO:0072659;GO:0055114;GO:0003008;GO:0044700;GO:0016192;GO:0044707;GO:0045650;GO:0050730;GO:0010243;GO:0071320;GO:0007009;GO:0016051;GO:0002376;GO:0033002;GO:0098916;GO:0010629;GO:0009725;GO:0033673;GO:0042391;GO:0022607;GO:0022603;GO:0072216;GO:0051100;GO:0006928;GO:0009062;GO:0051674;GO:0043170;GO:0097659;GO:0006629;GO:0043549;GO:0016477;GO:0045721;GO:0070208;GO:0034097;GO:0006810;GO:0044710;GO:0006952;GO:0012501;GO:0006950;GO:0072112;GO:0006954;GO:1902532;GO:1902533;GO:1902531;GO:0035789;GO:0035788;GO:0046903;GO:0044271;GO:0046907;GO:0036293;GO:0080134;GO:0031401;GO:0035787;GO:0006355;GO:0006351;GO:0099536;GO:0099537;GO:0032774;GO:2000477;GO:0032800;GO:2000479;GO:2000478;GO:0030155;GO:0030154;GO:0044723;GO:0072313;GO:0016054;GO:0072311;GO:0072310;GO:1904950;GO:0046777;GO:0009719;GO:0006139;GO:0032374;GO:0032376;GO:0032371;GO:0032370;GO:0032373;GO:0032270;GO:0051048;GO:0014910;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:0060627;GO:0072009;GO:0072001;GO:0032879;GO:0072006;GO:0051259;GO:0001959;GO:0071407;GO:0051253;GO:0051252;GO:0001816;GO:0001817;GO:0010470;GO:0006006;GO:0031400;GO:0001818;GO:0001819;GO:0032602;GO:2000698;GO:0050764;GO:2000696;GO:0002573;GO:0015758;GO:0071704;GO:0071310;GO:0071706;GO:0071702;GO:0030336;GO:0030334;GO:0034612;GO:0034613;GO:0023061;GO:2000590;GO:0051174;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0051649;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0042180;GO:0071639;GO:1901652;GO:1901653;GO:1902580;GO:0034654;GO:0071637;GO:0080090;GO:0010804;GO:0010803;GO:0061024;GO:0051899;GO:0023014;GO:0009755;GO:0010605;GO:0010604;GO:0070727;GO:0009611;GO:0018193;GO:0010033;GO:0045834;GO:0060255;GO:2000481;GO:0014823;GO:0032835;GO:0032787;GO:0051591;GO:0045995;GO:0072329;GO:0010871;GO:0010876;GO:0010874;GO:0010875;GO:0070586;GO:0070587;GO:0048870;GO:0048878;GO:0010737;GO:0019438;GO:0010739;GO:0010738;GO:0072312;GO:0032640;GO:0032642;GO:0090184;GO:0090185;GO:0090183;GO:0090077;GO:0032940;GO:1903556;GO:1903555;GO:1901576;GO:1901575;GO:0045649;GO:0071356;GO:0016043;GO:0016042;GO:0065003;GO:0065007;GO:0035850;GO:0001960;GO:0065009;GO:0065008;GO:0008015;GO:0036211;GO:0008150;GO:0008152;GO:0034285;GO:0043255;GO:1901698;GO:1901699;GO:0045638;GO:0048659;GO:0045637;GO:0031960;GO:0006869;GO:0016310;GO:0050805;GO:0030301;GO:0023056;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043086;GO:0043085;GO:0010642;GO:0022610;GO:0090192;GO:0009628;GO:0060429;GO:0045597;GO:0045596;GO:0045595;GO:0045892;GO:0001101;GO:0045599;GO:0045598;GO:0051093;GO:0032269;GO:0032268;GO:0006082;GO:0051094;GO:0005996;GO:0072210;GO:0051098;GO:0007249;GO:0048008;GO:1900121;GO:1900120;GO:0030099;GO:0030097;GO:0045860;GO:0071495;GO:0009991;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0019752;GO:0090304;GO:0014909;GO:0010942;GO:0032868;GO:0010941;GO:0072073;GO:0071822;GO:0071417;GO:0051260;GO:0033500;GO:0098801;GO:0010467;GO:0044085;GO:0010745;GO:0048534;GO:0010468;GO:0010742;GO:0010743;GO:0048662;GO:0015749;GO:0048660;GO:0072244;GO:2000534;GO:0032637;GO:2000532;GO:0015031;GO:0002762;GO:0007155;GO:0007154;GO:1903507;GO:0072243;GO:0045777;GO:0045776;GO:0032870;GO:0032680;GO:2000583;GO:0033344;GO:2000584;GO:0033028;GO:2000589;GO:0001933;GO:0001932;GO:0044249;GO:0001934;GO:0001655; regulation of intracellular protein transport;phagocytosis;regulation of secretion;macrophage differentiation;regulation of transport;small molecule metabolic process;small molecule catabolic process;small molecule biosynthetic process;regulation of metanephric glomerulus development;cytokine-mediated signaling pathway;cellular response to stimulus;ERK1 and ERK2 cascade;response to hypoxia;peptidyl-tyrosine modification;regulation of granulocyte differentiation;negative regulation of granulocyte differentiation;granulocyte differentiation;regulation of epithelial cell differentiation;epithelial cell differentiation;monocyte chemotactic protein-1 production;positive regulation of epithelial cell differentiation;regulation of intracellular transport;negative regulation of intracellular transport;cell development;regulation of protein kinase activity;protein heterooligomerization;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;negative regulation of phosphorylation;response to external stimulus;response to monosaccharide;protein metabolic process;response to fatty acid;response to linoleic acid;negative regulation of metabolic process;positive regulation of metabolic process;low-density lipoprotein receptor particle metabolic process;regulation of protein autophosphorylation;negative regulation of protein autophosphorylation;regulation of glucose metabolic process;regulation of protein binding;response to monoamine;cellular response to monoamine stimulus;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;negative regulation of protein transport;regulation of biological process;negative regulation of protein binding;positive regulation of transferase activity;hexose transport;intracellular protein transport;negative regulation of transferase activity;carbohydrate transport;regulation of immune system process;negative regulation of immune system process;regulation of gluconeogenesis;negative regulation of carbohydrate metabolic process;heterocycle biosynthetic process;regulation of establishment of protein localization;single organism cell adhesion;circadian rhythm;protein trimerization;cell-cell adhesion;regulation of biosynthetic process;negative regulation of DNA biosynthetic process;regulation of DNA biosynthetic process;positive regulation of glomerulus development;tissue development;macromolecule modification;negative regulation of response to cytokine stimulus;fatty acid oxidation;leukocyte differentiation;immune system development;RNA metabolic process;cellular response to cytokine stimulus;regulation of macromolecule biosynthetic process;response to steroid hormone;cellular developmental process;single-organism membrane organization;response to alcohol;negative regulation of macromolecule biosynthetic process;response to epinephrine;MAPK cascade;tumor necrosis factor-mediated signaling pathway;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;response to purine-containing compound;response to organic cyclic compound;negative regulation of cellular protein localization;regulation of cell development;renal absorption;negative regulation of cell proliferation;cell proliferation;brown fat cell differentiation;negative regulation of I-kappaB kinase/NF-kappaB signaling;regulation of hormone secretion;regulation of cellular carbohydrate metabolic process;metanephros development;negative regulation of cellular carbohydrate metabolic process;negative regulation of hormone secretion;cellular lipid metabolic process;lipid modification;response to oxidative stress;glucose homeostasis;negative regulation of tumor necrosis factor production;low-density lipoprotein particle clearance;positive regulation of fatty acid metabolic process;regulation of cellular localization;peptidyl-tyrosine phosphorylation;homeostatic process;regulation of cell-cell adhesion;regulation of glucose transport;cellular response to drug;regulation of blood pressure;fat cell differentiation;cell death;positive regulation of glucose transport;negative regulation of cell-cell adhesion;gluconeogenesis;response to lipid;cell differentiation involved in metanephros development;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;metanephric epithelium development;multicellular organism development;positive regulation of apoptotic process;regulation of programmed cell death;response to organophosphorus;embryonic morphogenesis;protein phosphorylation;negative regulation of protein kinase activity;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;protein complex assembly;negative regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;regulation of endocytosis;generation of precursor metabolites and energy;response to oxygen-containing compound;cellular response to oxygen-containing compound;negative regulation of locomotion;regulation of locomotion;regulation of carbohydrate metabolic process;anatomical structure development;hormone transport;negative regulation of leukocyte differentiation;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;receptor metabolic process;positive regulation of interleukin-8 production;negative regulation of cellular process;positive regulation of cellular process;lipid oxidation;negative regulation of heterotypic cell-cell adhesion;regulation of heterotypic cell-cell adhesion;heterotypic cell-cell adhesion;negative regulation of defense response;negative regulation of cell adhesion;circulatory system process;renal system process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of defense response;single-organism catabolic process;negative regulation of inflammatory response;single-organism biosynthetic process;gastrulation;endomembrane system organization;regulation of inflammatory response;positive regulation of molecular function;negative regulation of molecular function;positive regulation of myeloid cell apoptotic process;macromolecule localization;epithelial cell development;regulation of myeloid cell apoptotic process;negative regulation of DNA metabolic process;regulation of DNA metabolic process;negative regulation of transport;positive regulation of transport;cellular response to peptide hormone stimulus;regulation of RNA biosynthetic process;modulation of synaptic transmission;regulation of hemopoiesis;negative regulation of hemopoiesis;cell-cell adhesion via plasma-membrane adhesion molecules;cellular catabolic process;embryo development;response to nutrient levels;positive regulation of programmed cell death;positive regulation of peptidyl-tyrosine phosphorylation;low-density lipoprotein particle receptor biosynthetic process;negative regulation of low-density lipoprotein particle receptor biosynthetic process;regulation of low-density lipoprotein particle receptor biosynthetic process;regulation of secretion by cell;sterol transport;organic hydroxy compound transport;cell differentiation involved in kidney development;glucose import;nitrogen compound metabolic process;regulation of glucose import;platelet-derived growth factor receptor-alpha signaling pathway;positive regulation of glucose import;cellular lipid catabolic process;metanephric glomerulus development;regulation of myeloid leukocyte differentiation;cellular protein metabolic process;anatomical structure morphogenesis;cellular carbohydrate metabolic process;cellular macromolecule metabolic process;detection of oxidative stress;metanephric glomerular visceral epithelial cell development;metanephric glomerular visceral epithelial cell differentiation;regulation of platelet-derived growth factor receptor signaling pathway;protein complex biogenesis;renal filtration cell differentiation;negative regulation of MAPK cascade;regulation of protein localization;response to nutrient;apoptotic process;positive regulation of glycogen (starch) synthase activity;regulation of glycogen (starch) synthase activity;regulation of developmental process;regulation of catalytic activity;hexose metabolic process;hexose biosynthetic process;regulation of cellular process;positive regulation of metanephric glomerulus development;cellular response to epinephrine stimulus;regulation of multicellular organismal process;cellular response to catecholamine stimulus;regulation of plasma lipoprotein particle levels;establishment of localization;negative regulation of RNA biosynthetic process;endocytosis;regulation of lipid transport;carboxylic acid catabolic process;response to stimulus;plasma lipoprotein particle clearance;regulation of transferase activity;regulation of cell motility;renal protein absorption;negative regulation of cell motility;renal albumin absorption;positive regulation of kinase activity;positive regulation of multicellular organismal process;fatty acid metabolic process;negative regulation of multicellular organismal process;negative regulation of response to external stimulus;fatty acid beta-oxidation;regulation of response to external stimulus;regulation of cellular ketone metabolic process;negative regulation of MAP kinase activity;regulation of MAP kinase activity;negative regulation of secretion by cell;regulation of response to cytokine stimulus;cellular response to chemical stimulus;protein localization to cell periphery;single-organism process;regulation of MAPK cascade;glomerular visceral epithelial cell development;negative regulation of protein metabolic process;negative regulation of phagocytosis;glomerular epithelium development;negative regulation of biosynthetic process;regulation of system process;positive regulation of phosphorus metabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of protein modification process;regulation of interleukin-8 production;regulation of response to wounding;negative regulation of response to wounding;adiponectin-activated signaling pathway;locomotion;negative regulation of smooth muscle cell migration;negative regulation of cellular component movement;regulation of cellular component movement;muscle cell migration;regulation of receptor biosynthetic process;system development;negative regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;DNA biosynthetic process;response to glucocorticoid;single organismal cell-cell adhesion;negative regulation of metanephros development;macromolecular complex subunit organization;monosaccharide biosynthetic process;response to catecholamine;negative regulation of protein serine/threonine kinase activity;regulation of protein transport;regulation of apoptotic process;organic cyclic compound metabolic process;regulation of leukocyte differentiation;regulation of metanephros development;negative regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;negative regulation of phosphate metabolic process;regulation of hormone levels;response to ethanol;synaptic transmission;cell-cell signaling;response to chemical;response to oxygen levels;response to hexose;primary metabolic process;response to sucrose;carbohydrate metabolic process;response to carbohydrate;cellular metabolic process;response to glucose;DNA metabolic process;negative regulation of endocytosis;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;protein localization;membrane hyperpolarization;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;kidney development;hormone secretion;rhythmic process;animal organ development;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;positive regulation of chemokine production;regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell proliferation;response to drug;establishment of protein localization;cellular response to insulin stimulus;protein localization to membrane;oxoacid metabolic process;response to peptide hormone;protein localization to plasma membrane;oxidation-reduction process;system process;single organism signaling;vesicle-mediated transport;single-multicellular organism process;negative regulation of macrophage differentiation;regulation of peptidyl-tyrosine phosphorylation;response to organonitrogen compound;cellular response to cAMP;plasma membrane organization;carbohydrate biosynthetic process;immune system process;muscle cell proliferation;anterograde trans-synaptic signaling;negative regulation of gene expression;response to hormone;negative regulation of kinase activity;regulation of membrane potential;cellular component assembly;regulation of anatomical structure morphogenesis;positive regulation of metanephros development;negative regulation of binding;movement of cell or subcellular component;fatty acid catabolic process;localization of cell;macromolecule metabolic process;nucleic acid-templated transcription;lipid metabolic process;regulation of kinase activity;cell migration;negative regulation of gluconeogenesis;protein heterotrimerization;response to cytokine;transport;single-organism metabolic process;defense response;programmed cell death;response to stress;glomerular visceral epithelial cell differentiation;inflammatory response;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;metanephric mesenchymal cell migration;cell migration involved in metanephros development;secretion;cellular nitrogen compound biosynthetic process;intracellular transport;response to decreased oxygen levels;regulation of response to stress;positive regulation of protein modification process;cell migration involved in kidney development;regulation of transcription, DNA-templated;transcription, DNA-templated;synaptic signaling;trans-synaptic signaling;RNA biosynthetic process;regulation of metanephric glomerular visceral epithelial cell development;receptor biosynthetic process;regulation of cAMP-dependent protein kinase activity;positive regulation of metanephric glomerular visceral epithelial cell development;regulation of cell adhesion;cell differentiation;single-organism carbohydrate metabolic process;metanephric glomerular epithelial cell development;organic acid catabolic process;glomerular epithelial cell differentiation;glomerular epithelial cell development;negative regulation of establishment of protein localization;protein autophosphorylation;response to endogenous stimulus;nucleobase-containing compound metabolic process;regulation of cholesterol transport;positive regulation of cholesterol transport;regulation of sterol transport;positive regulation of lipid transport;positive regulation of sterol transport;positive regulation of cellular protein metabolic process;negative regulation of secretion;regulation of smooth muscle cell migration;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of vesicle-mediated transport;nephron epithelium development;renal system development;regulation of localization;nephron development;protein oligomerization;regulation of cytokine-mediated signaling pathway;cellular response to organic cyclic compound;negative regulation of RNA metabolic process;regulation of RNA metabolic process;cytokine production;regulation of cytokine production;regulation of gastrulation;glucose metabolic process;negative regulation of protein modification process;negative regulation of cytokine production;positive regulation of cytokine production;chemokine production;positive regulation of epithelial cell differentiation involved in kidney development;regulation of phagocytosis;regulation of epithelial cell differentiation involved in kidney development;myeloid leukocyte differentiation;glucose transport;organic substance metabolic process;cellular response to organic substance;tumor necrosis factor superfamily cytokine production;organic substance transport;negative regulation of cell migration;regulation of cell migration;response to tumor necrosis factor;cellular protein localization;signal release;negative regulation of metanephric mesenchymal cell migration;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;catabolic process;localization;single-organism localization;cellular localization;cellular ketone metabolic process;positive regulation of monocyte chemotactic protein-1 production;response to peptide;cellular response to peptide;single-organism cellular localization;nucleobase-containing compound biosynthetic process;regulation of monocyte chemotactic protein-1 production;regulation of primary metabolic process;negative regulation of tumor necrosis factor-mediated signaling pathway;regulation of tumor necrosis factor-mediated signaling pathway;membrane organization;membrane depolarization;signal transduction by protein phosphorylation;hormone-mediated signaling pathway;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to wounding;peptidyl-amino acid modification;response to organic substance;positive regulation of lipid metabolic process;regulation of macromolecule metabolic process;positive regulation of cAMP-dependent protein kinase activity;response to activity;glomerulus development;monocarboxylic acid metabolic process;response to cAMP;regulation of embryonic development;monocarboxylic acid catabolic process;negative regulation of receptor biosynthetic process;lipid localization;regulation of cholesterol efflux;positive regulation of cholesterol efflux;cell-cell adhesion involved in gastrulation;regulation of cell-cell adhesion involved in gastrulation;cell motility;chemical homeostasis;protein kinase A signaling;aromatic compound biosynthetic process;positive regulation of protein kinase A signaling;regulation of protein kinase A signaling;metanephric glomerular epithelial cell differentiation;tumor necrosis factor production;regulation of chemokine production;positive regulation of kidney development;negative regulation of kidney development;regulation of kidney development;foam cell differentiation;secretion by cell;negative regulation of tumor necrosis factor superfamily cytokine production;regulation of tumor necrosis factor superfamily cytokine production;organic substance biosynthetic process;organic substance catabolic process;regulation of macrophage differentiation;cellular response to tumor necrosis factor;cellular component organization;lipid catabolic process;macromolecular complex assembly;biological regulation;epithelial cell differentiation involved in kidney development;negative regulation of cytokine-mediated signaling pathway;regulation of molecular function;regulation of biological quality;blood circulation;protein modification process;biological_process;metabolic process;response to disaccharide;regulation of carbohydrate biosynthetic process;response to nitrogen compound;cellular response to nitrogen compound;negative regulation of myeloid cell differentiation;smooth muscle cell proliferation;regulation of myeloid cell differentiation;response to corticosteroid;lipid transport;phosphorylation;negative regulation of synaptic transmission;cholesterol transport;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;positive regulation of catalytic activity;negative regulation of platelet-derived growth factor receptor signaling pathway;biological adhesion;regulation of glomerulus development;response to abiotic stimulus;epithelium development;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;response to acid chemical;negative regulation of fat cell differentiation;regulation of fat cell differentiation;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;organic acid metabolic process;positive regulation of developmental process;monosaccharide metabolic process;metanephric nephron development;regulation of binding;I-kappaB kinase/NF-kappaB signaling;platelet-derived growth factor receptor signaling pathway;negative regulation of receptor binding;regulation of receptor binding;myeloid cell differentiation;hemopoiesis;positive regulation of protein kinase activity;cellular response to endogenous stimulus;response to extracellular stimulus;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;nucleic acid metabolic process;smooth muscle cell migration;positive regulation of cell death;response to insulin;regulation of cell death;kidney epithelium development;protein complex subunit organization;cellular response to organonitrogen compound;protein homooligomerization;carbohydrate homeostasis;regulation of renal system process;gene expression;cellular component biogenesis;negative regulation of macrophage derived foam cell differentiation;hematopoietic or lymphoid organ development;regulation of gene expression;macrophage derived foam cell differentiation;regulation of macrophage derived foam cell differentiation;negative regulation of smooth muscle cell proliferation;monosaccharide transport;regulation of smooth muscle cell proliferation;metanephric glomerular epithelium development;positive regulation of renal albumin absorption;interleukin-8 production;regulation of renal albumin absorption;protein transport;negative regulation of myeloid leukocyte differentiation;cell adhesion;cell communication;negative regulation of nucleic acid-templated transcription;metanephric nephron epithelium development;positive regulation of blood pressure;negative regulation of blood pressure;cellular response to hormone stimulus;regulation of tumor necrosis factor production;regulation of platelet-derived growth factor receptor-alpha signaling pathway;cholesterol efflux;negative regulation of platelet-derived growth factor receptor-alpha signaling pathway;myeloid cell apoptotic process;regulation of metanephric mesenchymal cell migration;negative regulation of protein phosphorylation;regulation of protein phosphorylation;cellular biosynthetic process;positive regulation of protein phosphorylation;urogenital system development; 6;5;5;8;4;4;5;5;6;6;3;6;4;8;7;7;8;5;6;6;5;5;4;4;7;7;4;7;7;7;3;6;4;5;6;3;3;6;8;8;6;5;5;6;9;5;8;4;2;6;6;7;6;6;5;3;3;6;4;5;5;3;3;7;4;4;6;6;5;4;5;4;6;6;3;5;6;5;5;4;4;5;5;6;5;7;4;4;5;5;5;3;5;5;4;3;7;6;4;5;5;5;4;4;5;4;7;6;5;5;4;8;4;5;5;5;4;6;4;4;5;8;5;6;6;6;6;4;6;5;5;4;7;8;6;5;5;5;4;6;3;4;3;5;4;4;5;3;3;5;3;5;5;5;4;4;5;5;3;3;5;6;6;5;4;4;4;4;4;5;6;7;5;4;5;4;5;4;5;4;4;7;3;5;7;5;5;3;3;6;6;4;4;4;5;4;5;5;5;8;5;6;6;5;6;5;5;9;3;6;9;5;5;5;6;5;3;4;4;5;8;8;5;4;6;6;4;4;6;7;6;3;4;6;7;3;6;7;3;6;3;3;6;6;5;6;2;4;5;4;6;4;7;7;3;5;3;4;7;4;5;7;7;4;4;4;6;2;6;7;5;5;5;4;4;5;5;5;5;6;5;5;4;6;2;6;4;4;5;5;4;7;7;6;7;4;5;4;6;5;9;5;6;4;5;6;5;6;6;4;6;8;4;3;4;7;3;7;4;5;3;8;5;4;6;3;3;3;3;4;5;5;2;4;4;4;4;6;2;4;5;2;2;5;6;6;4;4;4;7;5;5;5;6;4;3;3;5;3;7;8;4;6;5;5;2;4;7;5;4;7;4;4;4;5;5;4;6;3;4;7;4;6;4;6;8;5;4;3;4;5;3;7;5;5;5;5;7;6;5;5;5;5;4;6;5;6;6;5;6;6;6;6;9;6;4;5;4;7;5;6;6;3;8;3;4;7;6;6;4;5;5;4;6;2;2;2;4;7;4;5;5;3;4;6;5;6;5;5;4;4;5;7;6;4;4;5;5;6;6;7;8;3;5;5;5;5;5;6;5;5;6;5;3;5;4;4;4;3;2;3;3;4;6;5;6;4;5;6;4;6;6;4;5;4;5;4;4;4;4;7;4;4;4;10;3;4;7;5;5;7;5;4;8;7;5;6;3;5;6;5;6;6;7;6;5;4;4;5;6;4;5;5;4;4;7;7;3;5;5;2;5;5;3;3;5;5;1;2;6;5;4;5;5;5;5;6;5;6;4;7;3;3;4;2;4;5;3;4;4;5;5;5;2;5;3;5;4;4;4;6;4;5;5;3;5;5;4;3;5;5;4;6;8;7;6;6;5;8;4;4;5;5;4;4;4;6;5;6;4;6;4;5;5;5;7;6;5;5;3;5;4;5;7;5;5;6;5;6;4;5;6;5;6;3;4;7;6;5;5;5;6;6;8;6;7;6;7;7;4;7;5; GO:0044424;GO:0044464;GO:0070062;GO:0005615;GO:0043234;GO:0043230;GO:0043231;GO:0005581;GO:0044421;GO:0005783;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0031982;GO:0044444;GO:0009986;GO:0005576;GO:0005737;GO:1903561;GO:0005623;GO:0005622;GO:0032991;GO:0005575; intracellular part;cell part;extracellular exosome;extracellular space;protein complex;extracellular organelle;intracellular membrane-bounded organelle;collagen trimer;extracellular region part;endoplasmic reticulum;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;vesicle;cytoplasmic part;cell surface;extracellular region;cytoplasm;extracellular vesicle;cell;intracellular;macromolecular complex;cellular_component; 3;2;4;3;3;3;4;4;2;4;3;3;2;3;4;4;3;2;4;3;2;3;2;1; GO:0005488;GO:0046983;GO:0033691;GO:0005515;GO:0005102;GO:0003674;GO:0031406;GO:0043167;GO:0042802;GO:0042803;GO:0097367;GO:0005125;GO:0043177;GO:0036094;GO:0005179;GO:0043168; binding;protein dimerization activity;sialic acid binding;protein binding;receptor binding;molecular_function;carboxylic acid binding;ion binding;identical protein binding;protein homodimerization activity;carbohydrate derivative binding;cytokine activity;organic acid binding;small molecule binding;hormone activity;anion binding; 2;4;4;3;4;1;5;3;4;5;3;5;4;3;5;4; K07296 map03320;map04152;map04211;map04920;map04930;map04932; PPAR signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Adipocytokine signaling pathway;Type II diabetes mellitus;Non-alcoholic fatty liver disease (NAFLD); IPR008983;IPR008160;IPR001073; Tumour necrosis factor-like domain;Collagen triple helix repeat;C1q domain; extracellular 220924772 52.0 MU [M] Cell wall/membrane/envelope biogenesis; [U] Intracellular trafficking, secretion, and vesicular transport; COG3468 Type V secretory pathway, adhesin AidA Q9BSL1 Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1 - [UBAC1_HUMAN] 0.619 0.776 1.673 0.811 1.073 1.022 0.797680412 0.466347449 0.75582479 0.220936816 2.155927835 0.136718594 0.952469711 0.716810312 GO:0044237;GO:0043170;GO:0044267;GO:0044260;GO:0032446;GO:0070647;GO:0071704;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0016567; cellular metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;protein modification by small protein conjugation;protein modification by small protein conjugation or removal;organic substance metabolic process;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;protein ubiquitination; 3;4;5;4;8;7;3;2;6;5;5;1;2;3;4;9; GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0016020;GO:0005794;GO:0012505;GO:0005886;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421; intracellular organelle;cell periphery;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;membrane;Golgi apparatus;endomembrane system;plasma membrane;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part; 3;3;3;2;4;4;2;4;3;3;3;4;3;4;2;2;3;1;4;2;3;2; K12174 IPR006636;IPR009060;IPR015940;IPR029071; Heat shock chaperonin-binding;UBA-like;Ubiquitin-associated domain;Ubiquitin-related domain; cytosol Q8TEX9 Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2 - [IPO4_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0051169;GO:0008104;GO:0071840;GO:0070727;GO:0033036;GO:0071702;GO:0006606;GO:0006607;GO:0006605;GO:0045184;GO:0071103;GO:0022607;GO:0006610;GO:0006886;GO:0016043;GO:0065003;GO:0065004;GO:0006461;GO:0006810;GO:0008150;GO:0051234;GO:0046907;GO:0034728;GO:0070271;GO:0034723;GO:0034724;GO:0031497;GO:0044699;GO:1902593;GO:0072594;GO:0017038;GO:0044744;GO:0051276;GO:0000059;GO:0006336;GO:0006334;GO:0006335;GO:0006333;GO:0033365;GO:0034504;GO:0043933;GO:0034622;GO:0071824;GO:0071822;GO:0006325;GO:0000060;GO:0006323;GO:0009987;GO:0034613;GO:0006913;GO:0044765;GO:0051170;GO:0051649;GO:0043623;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044085;GO:0015031;GO:1902582;GO:1902580; nuclear transport;protein localization;cellular component organization or biogenesis;cellular macromolecule localization;macromolecule localization;organic substance transport;protein import into nucleus;NLS-bearing protein import into nucleus;protein targeting;establishment of protein localization;DNA conformation change;cellular component assembly;ribosomal protein import into nucleus;intracellular protein transport;cellular component organization;macromolecular complex assembly;protein-DNA complex assembly;protein complex assembly;transport;biological_process;establishment of localization;intracellular transport;nucleosome organization;protein complex biogenesis;DNA replication-dependent nucleosome organization;DNA replication-independent nucleosome organization;chromatin assembly;single-organism process;single-organism nuclear import;establishment of protein localization to organelle;protein import;protein targeting to nucleus;chromosome organization;protein import into nucleus, docking;DNA replication-independent nucleosome assembly;nucleosome assembly;DNA replication-dependent nucleosome assembly;chromatin assembly or disassembly;protein localization to organelle;protein localization to nucleus;macromolecular complex subunit organization;cellular macromolecular complex assembly;protein-DNA complex subunit organization;protein complex subunit organization;chromatin organization;protein import into nucleus, translocation;DNA packaging;cellular process;cellular protein localization;nucleocytoplasmic transport;single-organism transport;nuclear import;establishment of localization in cell;cellular protein complex assembly;localization;single-organism localization;cellular localization;organelle organization;cellular component biogenesis;protein transport;single-organism intracellular transport;single-organism cellular localization; 6;4;2;4;3;5;5;6;6;4;6;4;6;6;3;5;6;5;4;1;3;5;6;4;7;7;6;2;6;5;5;5;5;6;7;6;7;6;6;7;4;6;5;5;5;6;7;2;5;7;4;8;4;6;2;3;3;4;3;5;5;4; GO:0031974;GO:0031975;GO:0031981;GO:0016020;GO:0031967;GO:0000790;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0043228;GO:0000228;GO:0043227;GO:0043226;GO:0034399;GO:0012505;GO:0044446;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0044454;GO:0044464;GO:0005623;GO:0005622;GO:0000785;GO:0005694;GO:0031965;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;nuclear lumen;membrane;organelle envelope;nuclear chromatin;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;non-membrane-bounded organelle;nuclear chromosome;membrane-bounded organelle;organelle;nuclear periphery;endomembrane system;intracellular organelle part;cytoplasm;organelle membrane;nucleus;nuclear envelope;nuclear chromosome part;cell part;cell;intracellular;chromatin;chromosome;nuclear membrane;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;5;2;4;4;3;4;4;3;4;3;4;2;3;3;5;3;2;5;3;3;4;3;5;4;5;2;2;3;3;5;4;2;1;4; GO:0005215;GO:0003674;GO:0005488;GO:0008565;GO:0022892;GO:0042277;GO:0008139;GO:0033218;GO:0005048; transporter activity;molecular_function;binding;protein transporter activity;substrate-specific transporter activity;peptide binding;nuclear localization sequence binding;amide binding;signal sequence binding; 2;1;2;4;3;4;6;3;5; K20221 IPR021133;IPR000357;IPR001494;IPR016024;IPR034085;IPR011989; HEAT, type 2;HEAT repeat;Importin-beta, N-terminal domain;Armadillo-type fold;TOG domain;Armadillo-like helical; cytosol, nucleus Hs18874099 2157.0 YU [Y] Nuclear structure;[U] Intracellular trafficking, secretion, and vesicular transport; Q8NFJ9 Bardet-Biedl syndrome 1 protein OS=Homo sapiens OX=9606 GN=BBS1 PE=1 SV=1 - [BBS1_HUMAN] 0.992 0.955 1.072 1.112 0.986 1.235 1.038743456 0.844992534 1.127789047 0.021283573 1.122513089 0.492224158 1.252535497 0.121678028 GO:0008104;GO:0060249;GO:0061024;GO:0007009;GO:0032989;GO:0090002;GO:0071840;GO:0070727;GO:0048869;GO:0010256;GO:0033036;GO:0007601;GO:0007600;GO:0045184;GO:0072657;GO:0072659;GO:0003008;GO:0016192;GO:0044782;GO:0044707;GO:0022607;GO:1990778;GO:0000902;GO:0006886;GO:0016043;GO:0065007;GO:0065008;GO:0048646;GO:0042384;GO:0060271;GO:0006810;GO:0050953;GO:0008150;GO:0051234;GO:0006893;GO:0006892;GO:0046907;GO:0050896;GO:0044802;GO:0051649;GO:0010927;GO:0009653;GO:0044699;GO:0043001;GO:0032502;GO:0032501;GO:0050877;GO:0009987;GO:0001894;GO:0001895;GO:0048858;GO:0048871;GO:0061512;GO:0033365;GO:0030030;GO:0030031;GO:0042592;GO:0071702;GO:0035058;GO:0048193;GO:0034613;GO:0044767;GO:0044765;GO:0044763;GO:0070925;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0032990;GO:0090150;GO:0048856;GO:0045494;GO:1902589;GO:0044085;GO:0015031;GO:1902582;GO:1902580; protein localization;anatomical structure homeostasis;membrane organization;plasma membrane organization;cellular component morphogenesis;establishment of protein localization to plasma membrane;cellular component organization or biogenesis;cellular macromolecule localization;cellular developmental process;endomembrane system organization;macromolecule localization;visual perception;sensory perception;establishment of protein localization;protein localization to membrane;protein localization to plasma membrane;system process;vesicle-mediated transport;cilium organization;single-multicellular organism process;cellular component assembly;protein localization to cell periphery;cell morphogenesis;intracellular protein transport;cellular component organization;biological regulation;regulation of biological quality;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;transport;sensory perception of light stimulus;biological_process;establishment of localization;Golgi to plasma membrane transport;post-Golgi vesicle-mediated transport;intracellular transport;response to stimulus;single-organism membrane organization;establishment of localization in cell;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;single-organism process;Golgi to plasma membrane protein transport;developmental process;multicellular organismal process;neurological system process;cellular process;tissue homeostasis;retina homeostasis;cell projection morphogenesis;multicellular organismal homeostasis;protein localization to cilium;protein localization to organelle;cell projection organization;cell projection assembly;homeostatic process;organic substance transport;nonmotile primary cilium assembly;Golgi vesicle transport;cellular protein localization;single-organism developmental process;single-organism transport;single-organism cellular process;organelle assembly;localization;single-organism localization;cellular localization;organelle organization;cell part morphogenesis;establishment of protein localization to membrane;anatomical structure development;photoreceptor cell maintenance;single-organism organelle organization;cellular component biogenesis;protein transport;single-organism intracellular transport;single-organism cellular localization; 4;5;4;5;4;6;2;4;4;4;3;7;5;4;5;6;3;5;5;3;4;6;5;6;3;2;3;3;5;6;4;6;1;3;8;7;5;2;4;4;4;3;2;7;2;2;4;2;5;6;5;4;7;6;4;5;4;5;6;6;5;3;4;3;5;2;3;3;4;5;5;3;4;4;3;5;5;4; GO:0042995;GO:0016020;GO:0098588;GO:0098589;GO:0043234;GO:0043232;GO:0005829;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0060170;GO:0043229;GO:0043228;GO:0005929;GO:0043227;GO:0043226;GO:0005856;GO:0036064;GO:0044430;GO:0031253;GO:0005930;GO:0044446;GO:0044444;GO:0097014;GO:0044441;GO:0034464;GO:0005737;GO:0031090;GO:0044459;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0005813;GO:0098805;GO:0005815;GO:0015630;GO:0005886;GO:0032991;GO:0005575; cell projection;membrane;bounding membrane of organelle;membrane region;protein complex;intracellular non-membrane-bounded organelle;cytosol;intracellular part;membrane part;organelle part;plasma membrane region;ciliary membrane;intracellular organelle;non-membrane-bounded organelle;cilium;membrane-bounded organelle;organelle;cytoskeleton;ciliary basal body;cytoskeletal part;cell projection membrane;axoneme;intracellular organelle part;cytoplasmic part;ciliary plasm;ciliary part;BBSome;cytoplasm;organelle membrane;plasma membrane part;cell projection part;cell part;cell;intracellular;cell periphery;centrosome;whole membrane;microtubule organizing center;microtubule cytoskeleton;plasma membrane;macromolecular complex;cellular_component; 3;2;4;3;3;4;5;3;2;2;4;4;3;3;3;3;2;5;4;4;4;4;3;4;4;3;4;4;3;3;3;2;2;3;3;5;3;5;6;3;2;1; GO:0003674;GO:0005488;GO:0001085;GO:0008134;GO:0001103;GO:0005515;GO:0005102;GO:0070491;GO:0005119;GO:0005113; molecular_function;binding;RNA polymerase II transcription factor binding;transcription factor binding;RNA polymerase II repressing transcription factor binding;protein binding;receptor binding;repressing transcription factor binding;smoothened binding;patched binding; 1;2;5;4;6;3;4;5;5;5; K16746 IPR032728;IPR028784;IPR015943;IPR011047; Bardet-Biedl syndrome 1, N-terminal;Bardet-Biedl syndrome 1 protein;WD40/YVTN repeat-like-containing domain;Quinoprotein alcohol dehydrogenase-like superfamily; cytosol 7295290 277.0 S [S] Function unknown; Q9C0I3 Serine-rich coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CCSER1 PE=2 SV=2 - [CCSE1_HUMAN] 1.006 0.685 1.544 0.859 0.788 1.55 1.468613139 nan 1.090101523 nan 2.254014599 nan 1.967005076 nan IPR029627;IPR029628; Serine-rich coiled-coil domain-containing protein;Serine-rich coiled-coil domain-containing protein 1; mitochondria P05160 Coagulation factor XIII B chain OS=Homo sapiens OX=9606 GN=F13B PE=1 SV=3 - [F13B_HUMAN] 0.982 1.043 0.94 1.049 1.042 1.049 0.941514861 0.37349561 1.00671785 0.609912795 0.901246405 0.081227111 1.00671785 0.29697858 GO:0032501;GO:0007599;GO:0044707;GO:0050878;GO:0050896;GO:0007596;GO:0009611;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0065007;GO:0065008;GO:0044699; multicellular organismal process;hemostasis;single-multicellular organism process;regulation of body fluid levels;response to stimulus;blood coagulation;response to wounding;wound healing;response to stress;coagulation;biological_process;biological regulation;regulation of biological quality;single-organism process; 2;5;3;4;2;5;4;5;3;4;1;2;3;2; GO:0005575;GO:0005576; cellular_component;extracellular region; 1;2; K03906 map04610; Complement and coagulation cascades; IPR000436; Sushi/SCR/CCP domain; extracellular Q6Q0C0 E3 ubiquitin-protein ligase TRAF7 OS=Homo sapiens OX=9606 GN=TRAF7 PE=1 SV=1 - [TRAF7_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:2001235;GO:0019220;GO:0080090;GO:0019222;GO:2001233;GO:0048584;GO:0048583;GO:0032147;GO:0007165;GO:1901362;GO:0023014;GO:0051716;GO:0010604;GO:0009966;GO:0009967;GO:0000165;GO:0010467;GO:0032446;GO:0044093;GO:0048518;GO:0060255;GO:0045859;GO:2001141;GO:0046483;GO:0042325;GO:0044700;GO:0042327;GO:0019538;GO:0034641;GO:0010468;GO:0016567;GO:0019438;GO:0009893;GO:0033674;GO:0006807;GO:0071902;GO:0035556;GO:0071900;GO:0042981;GO:0050789;GO:0097659;GO:0044267;GO:0051347;GO:0070647;GO:0044260;GO:0043549;GO:0065007;GO:0043085;GO:0065009;GO:0018130;GO:0050790;GO:0009889;GO:0044710;GO:0050794;GO:0043410;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:1902533;GO:1902531;GO:0016070;GO:0044271;GO:0050896;GO:0031401;GO:0051338;GO:0006355;GO:0010556;GO:0006351;GO:0032774;GO:0016310;GO:0023056;GO:0044249;GO:0043405;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0043408;GO:0006139;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0097190;GO:0009987;GO:0006725;GO:1903506;GO:0032268;GO:0051252;GO:0043170;GO:0045860;GO:0000185;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0010942;GO:0008219;GO:0010941;GO:1901360;GO:2000112;GO:0043065;GO:0071704;GO:0043067;GO:0043068;GO:0006468;GO:0045937;GO:1901576;GO:0019219;GO:0006915;GO:0006464;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007154;GO:0044238;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048522; positive regulation of apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;signal transduction;organic cyclic compound biosynthetic process;signal transduction by protein phosphorylation;cellular response to stimulus;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;gene expression;protein modification by small protein conjugation;positive regulation of molecular function;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of protein kinase activity;regulation of RNA biosynthetic process;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;protein metabolic process;cellular nitrogen compound metabolic process;regulation of gene expression;protein ubiquitination;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of kinase activity;nitrogen compound metabolic process;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of apoptotic process;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;positive regulation of transferase activity;protein modification by small protein conjugation or removal;cellular macromolecule metabolic process;regulation of kinase activity;biological regulation;positive regulation of catalytic activity;regulation of molecular function;heterocycle biosynthetic process;regulation of catalytic activity;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;positive regulation of protein modification process;regulation of transferase activity;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;phosphorylation;positive regulation of signaling;cellular biosynthetic process;regulation of MAP kinase activity;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MAPK cascade;nucleobase-containing compound metabolic process;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;apoptotic signaling pathway;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular protein metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of protein kinase activity;activation of MAPKKK activity;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of cell death;cell death;regulation of cell death;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;positive regulation of programmed cell death;protein phosphorylation;positive regulation of phosphate metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;apoptotic process;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell communication;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 5;6;4;3;5;3;3;9;4;5;4;3;4;4;4;5;5;8;4;2;4;7;6;4;7;3;7;4;4;5;9;5;3;7;3;9;5;8;6;2;7;5;6;7;4;6;2;5;3;5;4;4;3;3;6;5;5;5;1;2;5;5;5;5;5;2;6;5;6;5;6;6;6;3;4;7;2;5;3;4;4;2;6;4;5;5;5;5;6;5;2;4;7;5;5;4;8;7;5;4;4;5;4;4;4;4;6;6;3;5;5;7;6;4;5;6;6;5;3;5;3;4;4;3;3;5;4;7;7;3; GO:0016020;GO:0031988;GO:0043234;GO:1902494;GO:1990234;GO:0043231;GO:0044424;GO:0000151;GO:0043229;GO:0097708;GO:0031982;GO:0044444;GO:0005737;GO:0031410;GO:0016023;GO:0044464;GO:0005623;GO:0071944;GO:0043227;GO:0043226;GO:0005622;GO:0005886;GO:0032991;GO:0005575; membrane;membrane-bounded vesicle;protein complex;catalytic complex;transferase complex;intracellular membrane-bounded organelle;intracellular part;ubiquitin ligase complex;intracellular organelle;intracellular vesicle;vesicle;cytoplasmic part;cytoplasm;cytoplasmic vesicle;cytoplasmic, membrane-bounded vesicle;cell part;cell;cell periphery;membrane-bounded organelle;organelle;intracellular;plasma membrane;macromolecular complex;cellular_component; 2;5;3;4;5;4;3;4;3;4;4;4;4;5;5;2;2;3;3;2;3;3;2;1; GO:0016740;GO:0046872;GO:0008270;GO:0003674;GO:0005488;GO:0019787;GO:0043169;GO:0004842;GO:0003824;GO:0043167;GO:0016874;GO:0046914; transferase activity;metal ion binding;zinc ion binding;molecular_function;binding;ubiquitin-like protein transferase activity;cation binding;ubiquitin-protein transferase activity;catalytic activity;ion binding;ligase activity;transition metal ion binding; 3;5;7;1;2;4;4;5;2;3;3;6; K10646 IPR020472;IPR017986;IPR001680;IPR017907;IPR001293;IPR013083;IPR015943;IPR019775;IPR027370;IPR001841;IPR008974; G-protein beta WD-40 repeat;WD40-repeat-containing domain;WD40 repeat;Zinc finger, RING-type, conserved site;Zinc finger, TRAF-type;Zinc finger, RING/FYVE/PHD-type;WD40/YVTN repeat-like-containing domain;WD40 repeat, conserved site;RING-type zinc-finger, LisH dimerisation motif;Zinc finger, RING-type;TRAF-like; nucleus Hs14150011_2 710.0 R [R] General function prediction only; P51884 Lumican OS=Homo sapiens OX=9606 GN=LUM PE=1 SV=2 - [LUM_HUMAN] 1.114 1.047 0.858 1.127 1.064 0.905 1.063992359 0.003108931 1.059210526 2.19E-06 0.819484241 6.79E-16 0.85056391 0.170237216 GO:0080090;GO:0019222;GO:0001501;GO:0044281;GO:1901362;GO:0071840;GO:0032774;GO:0044712;GO:0044710;GO:0044711;GO:0070848;GO:0042339;GO:0048513;GO:0048518;GO:0046483;GO:0060255;GO:0007601;GO:0007600;GO:2001141;GO:0043436;GO:0010033;GO:0003008;GO:0051216;GO:1901564;GO:0044707;GO:1902680;GO:0050789;GO:0030199;GO:0030198;GO:0019438;GO:0030203;GO:0009893;GO:0009891;GO:0018146;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:1901575;GO:0044260;GO:0016043;GO:0014070;GO:0006366;GO:0018130;GO:0009889;GO:0009888;GO:0050953;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0010604;GO:0016070;GO:0044271;GO:0044273;GO:0044272;GO:0050896;GO:0006355;GO:0006357;GO:0006351;GO:0006022;GO:0006023;GO:0006026;GO:0006027;GO:0006024;GO:1901565;GO:0051239;GO:0044248;GO:0044249;GO:0034641;GO:0034645;GO:1901566;GO:0044699;GO:0006139;GO:0051240;GO:0032502;GO:0032501;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:0071604;GO:0045893;GO:0005975;GO:0006082;GO:1901137;GO:1901136;GO:1901135;GO:0051252;GO:0051254;GO:0001816;GO:0001817;GO:0010628;GO:0045944;GO:0048731;GO:0001819;GO:1903508;GO:0048856;GO:0032908;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0032905;GO:0031323;GO:1903510;GO:0090304;GO:0007275;GO:0071822;GO:1901360;GO:2000112;GO:0010557;GO:0071704;GO:0010467;GO:0010556;GO:0043062;GO:0010468;GO:0045935;GO:0019219;GO:0032914;GO:0061448;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0042221;GO:0009056;GO:0009057;GO:0044238;GO:0042340;GO:0065007;GO:0044237;GO:0071634;GO:0006790;GO:0048522;GO:0071636; regulation of primary metabolic process;regulation of metabolic process;skeletal system development;small molecule metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;RNA biosynthetic process;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;response to growth factor;keratan sulfate metabolic process;animal organ development;positive regulation of biological process;heterocycle metabolic process;regulation of macromolecule metabolic process;visual perception;sensory perception;regulation of RNA biosynthetic process;oxoacid metabolic process;response to organic substance;system process;cartilage development;organonitrogen compound metabolic process;single-multicellular organism process;positive regulation of RNA biosynthetic process;regulation of biological process;collagen fibril organization;extracellular matrix organization;aromatic compound biosynthetic process;glycosaminoglycan metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;keratan sulfate biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule metabolic process;cellular component organization;response to organic cyclic compound;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;tissue development;sensory perception of light stimulus;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of macromolecule metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;sulfur compound catabolic process;sulfur compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;aminoglycan metabolic process;aminoglycan biosynthetic process;aminoglycan catabolic process;glycosaminoglycan catabolic process;glycosaminoglycan biosynthetic process;organonitrogen compound catabolic process;regulation of multicellular organismal process;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organonitrogen compound biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;positive regulation of multicellular organismal process;developmental process;multicellular organismal process;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;transforming growth factor beta production;positive regulation of transcription, DNA-templated;carbohydrate metabolic process;organic acid metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;cytokine production;regulation of cytokine production;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;system development;positive regulation of cytokine production;positive regulation of nucleic acid-templated transcription;anatomical structure development;regulation of transforming growth factor beta1 production;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;transforming growth factor beta1 production;regulation of cellular metabolic process;mucopolysaccharide metabolic process;nucleic acid metabolic process;multicellular organism development;protein complex subunit organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;extracellular structure organization;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;positive regulation of transforming growth factor beta1 production;connective tissue development;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;catabolic process;macromolecule catabolic process;primary metabolic process;keratan sulfate catabolic process;biological regulation;cellular metabolic process;regulation of transforming growth factor beta production;sulfur compound metabolic process;positive regulation of cellular process;positive regulation of transforming growth factor beta production; 4;3;5;4;5;2;6;4;3;4;5;5;4;2;4;4;7;5;6;5;4;3;5;4;3;6;2;6;5;5;6;3;4;6;3;4;7;4;4;4;3;5;7;5;4;4;6;3;1;2;5;4;5;5;5;5;2;6;7;6;5;5;6;7;6;5;3;4;4;4;5;5;2;4;3;2;2;4;2;4;7;5;6;4;4;5;5;4;5;5;4;4;5;7;4;4;7;3;6;5;4;5;4;6;4;7;5;4;5;4;6;5;3;5;5;4;5;5;5;6;5;3;3;5;3;4;4;3;3;5;3;5;2;3;5;4;3;5; GO:0031974;GO:0031982;GO:0005773;GO:0005775;GO:0098644;GO:0098643;GO:0005794;GO:0005796;GO:0043230;GO:0043234;GO:0043231;GO:0043233;GO:0044424;GO:0044420;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044431;GO:0044437;GO:0043202;GO:0012505;GO:0044446;GO:0044444;GO:0000323;GO:0031012;GO:0005737;GO:0005581;GO:0005583;GO:0044464;GO:0005623;GO:0005622;GO:0005764;GO:0070062;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0070013;GO:0005576;GO:0005578; membrane-enclosed lumen;vesicle;vacuole;vacuolar lumen;complex of collagen trimers;banded collagen fibril;Golgi apparatus;Golgi lumen;extracellular organelle;protein complex;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular matrix component;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;Golgi apparatus part;vacuolar part;lysosomal lumen;endomembrane system;intracellular organelle part;cytoplasmic part;lytic vacuole;extracellular matrix;cytoplasm;collagen trimer;fibrillar collagen trimer;cell part;cell;intracellular;lysosome;extracellular exosome;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region;proteinaceous extracellular matrix; 2;4;5;5;3;4;4;5;3;3;4;3;3;2;2;2;3;3;2;4;4;6;3;3;4;6;2;4;4;3;2;2;3;7;4;3;3;2;1;4;2;3; GO:0044877;GO:0003674;GO:0005488;GO:0032403;GO:0005515;GO:0005518;GO:0005201;GO:0005198; macromolecular complex binding;molecular_function;binding;protein complex binding;protein binding;collagen binding;extracellular matrix structural constituent;structural molecule activity; 3;1;2;4;3;5;3;2; K08122 map05205; Proteoglycans in cancer; IPR003591;IPR001611;IPR032675;IPR000372;IPR027219; Leucine-rich repeat, typical subtype;Leucine-rich repeat;Leucine-rich repeat domain, L domain-like;Leucine-rich repeat N-terminal domain;Lumican; extracellular Hs4505047 684.0 R [R] General function prediction only; P03952 Plasma kallikrein OS=Homo sapiens OX=9606 GN=KLKB1 PE=1 SV=1 - [KLKB1_HUMAN] 1.025 1.047 1.063 0.979 1.04 0.77 0.978987584 0.56849012 0.941346154 0.11766056 1.015281757 0.012179395 0.740384615 0.103995994 GO:0007599;GO:0080090;GO:0019222;GO:0048585;GO:0007596;GO:0048583;GO:0031349;GO:0031347;GO:0044710;GO:0050729;GO:0010604;GO:0050727;GO:0048513;GO:0048518;GO:0048519;GO:0007597;GO:0048584;GO:0060255;GO:0030162;GO:0002673;GO:0002675;GO:0009605;GO:0044707;GO:0019538;GO:0030198;GO:0030193;GO:0030195;GO:0009893;GO:0061008;GO:0008152;GO:0010628;GO:0050789;GO:0044267;GO:0044260;GO:0016043;GO:1900046;GO:1900047;GO:0065007;GO:0071840;GO:0065008;GO:0042060;GO:0050794;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0006954;GO:0048731;GO:0002526;GO:0050818;GO:0050819;GO:0042730;GO:0070613;GO:0051604;GO:0097421;GO:0050896;GO:0002353;GO:1903319;GO:0022411;GO:1903317;GO:0032102;GO:0032103;GO:0032101;GO:0031099;GO:0009611;GO:0044699;GO:0051241;GO:0051246;GO:0051247;GO:0051917;GO:0032270;GO:0006508;GO:1903034;GO:1903035;GO:1903036;GO:0051919;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0016485;GO:0032268;GO:0002541;GO:0022617;GO:0002542;GO:0043170;GO:0051239;GO:0045862;GO:0048732;GO:0080134;GO:0031325;GO:0031323;GO:0061041;GO:0001889;GO:0061045;GO:0007275;GO:0072376;GO:0072378;GO:0031100;GO:0031639;GO:0031638;GO:0071704;GO:0010467;GO:0043062;GO:0010468;GO:0044767;GO:0044763;GO:0010954;GO:0044238;GO:0048856;GO:0044237;GO:0002254;GO:0048522; hemostasis;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;positive regulation of defense response;regulation of defense response;single-organism metabolic process;positive regulation of inflammatory response;positive regulation of macromolecule metabolic process;regulation of inflammatory response;animal organ development;positive regulation of biological process;negative regulation of biological process;blood coagulation, intrinsic pathway;positive regulation of response to stimulus;regulation of macromolecule metabolic process;regulation of proteolysis;regulation of acute inflammatory response;positive regulation of acute inflammatory response;response to external stimulus;single-multicellular organism process;protein metabolic process;extracellular matrix organization;regulation of blood coagulation;negative regulation of blood coagulation;positive regulation of metabolic process;hepaticobiliary system development;metabolic process;positive regulation of gene expression;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;regulation of hemostasis;negative regulation of hemostasis;biological regulation;cellular component organization or biogenesis;regulation of biological quality;wound healing;regulation of cellular process;defense response;response to stress;coagulation;biological_process;inflammatory response;system development;acute inflammatory response;regulation of coagulation;negative regulation of coagulation;fibrinolysis;regulation of protein processing;protein maturation;liver regeneration;response to stimulus;plasma kallikrein-kinin cascade;positive regulation of protein maturation;cellular component disassembly;regulation of protein maturation;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;regeneration;response to wounding;single-organism process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of fibrinolysis;positive regulation of cellular protein metabolic process;proteolysis;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;positive regulation of fibrinolysis;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;protein processing;regulation of cellular protein metabolic process;activation of plasma proteins involved in acute inflammatory response;extracellular matrix disassembly;Factor XII activation;macromolecule metabolic process;regulation of multicellular organismal process;positive regulation of proteolysis;gland development;regulation of response to stress;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of wound healing;liver development;negative regulation of wound healing;multicellular organism development;protein activation cascade;blood coagulation, fibrin clot formation;organ regeneration;plasminogen activation;zymogen activation;organic substance metabolic process;gene expression;extracellular structure organization;regulation of gene expression;single-organism developmental process;single-organism cellular process;positive regulation of protein processing;primary metabolic process;anatomical structure development;cellular metabolic process;kinin cascade;positive regulation of cellular process; 5;4;3;3;5;3;4;5;3;5;4;5;4;2;2;4;3;4;6;6;6;3;3;4;5;5;5;3;5;2;5;2;5;4;3;4;4;2;2;3;5;3;4;3;4;1;5;4;6;4;4;6;7;5;6;2;5;6;4;6;4;4;4;4;4;2;3;5;5;6;5;5;5;4;4;3;2;2;4;2;6;5;7;5;6;4;3;6;4;4;4;4;6;5;5;4;3;4;5;8;7;3;5;4;5;3;3;7;3;3;3;4;3; GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0031982;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005576;GO:0005886;GO:1903561;GO:0005615;GO:0005575; membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;vesicle;cell part;cell;cell periphery;extracellular exosome;organelle;extracellular region;plasma membrane;extracellular vesicle;extracellular space;cellular_component; 2;3;2;3;4;2;2;3;4;2;2;3;3;3;1; GO:0004252;GO:0017171;GO:0003674;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;molecular_function;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;1;3;2;4;5;6;5; K01324 map04610; Complement and coagulation cascades; IPR003609;IPR001254;IPR000177;IPR018114;IPR009003;IPR034813;IPR033116;IPR001314; PAN/Apple domain;Serine proteases, trypsin domain;Apple domain;Serine proteases, trypsin family, histidine active site;Peptidase S1, PA clan;Plasma kallikrein;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular Hs4504877 1333.0 E [E] Amino acid transport and metabolism; O43361 Zinc finger protein 749 OS=Homo sapiens OX=9606 GN=ZNF749 PE=1 SV=2 - [ZN749_HUMAN] 0.818 1.14 1.335 0.906 1.006 0.718 0.71754386 nan 0.900596421 nan 1.171052632 nan 0.713717694 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; K09228 IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs18602253 578.0 R [R] General function prediction only; Q07617 Sperm-associated antigen 1 OS=Homo sapiens OX=9606 GN=SPAG1 PE=1 SV=3 - [SPAG1_HUMAN] 1.135 0.907 0.961 1.371 0.886 0.989 1.25137817 nan 1.547404063 nan 1.059536935 nan 1.116252822 nan GO:0071840;GO:0065003;GO:0000003;GO:0048869;GO:0051704;GO:0044703;GO:0044702;GO:0009566;GO:0044782;GO:0022607;GO:0000902;GO:0035082;GO:0016043;GO:0048646;GO:0042384;GO:0060271;GO:0008150;GO:0044767;GO:0001578;GO:0070271;GO:0019953;GO:0010927;GO:0009653;GO:0044699;GO:0070286;GO:0032502;GO:0030030;GO:0009987;GO:0007338;GO:0048858;GO:0000226;GO:0043933;GO:0030031;GO:0034622;GO:0071822;GO:0032989;GO:0006461;GO:0022414;GO:0044763;GO:0070925;GO:0043623;GO:0006996;GO:0007017;GO:0007010;GO:0032990;GO:0048856;GO:1902589;GO:0044085; cellular component organization or biogenesis;macromolecular complex assembly;reproduction;cellular developmental process;multi-organism process;multi-organism reproductive process;single organism reproductive process;fertilization;cilium organization;cellular component assembly;cell morphogenesis;axoneme assembly;cellular component organization;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;biological_process;single-organism developmental process;microtubule bundle formation;protein complex biogenesis;sexual reproduction;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;single-organism process;axonemal dynein complex assembly;developmental process;cell projection organization;cellular process;single fertilization;cell projection morphogenesis;microtubule cytoskeleton organization;macromolecular complex subunit organization;cell projection assembly;cellular macromolecular complex assembly;protein complex subunit organization;cellular component morphogenesis;protein complex assembly;reproductive process;single-organism cellular process;organelle assembly;cellular protein complex assembly;organelle organization;microtubule-based process;cytoskeleton organization;cell part morphogenesis;anatomical structure development;single-organism organelle organization;cellular component biogenesis; 2;5;2;4;2;3;3;4;5;4;5;5;3;3;5;6;1;3;6;4;3;4;3;2;5;2;4;2;5;5;5;4;5;6;5;4;5;2;3;5;6;4;4;5;5;3;4;3; GO:0031974;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005856;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0015630;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoskeleton;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;intracellular;microtubule cytoskeleton;cellular_component;intracellular organelle lumen; 2;5;4;4;3;4;3;2;3;3;3;2;5;5;3;4;5;2;2;3;6;1;4; GO:1901363;GO:0000166;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0016787;GO:0003824;GO:0019001;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0032561;GO:0097159;GO:0001883;GO:0001882;GO:0036094;GO:0043168; heterocyclic compound binding;nucleotide binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;hydrolase activity;catalytic activity;guanyl nucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;guanyl ribonucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;small molecule binding;anion binding; 3;4;3;1;2;4;5;5;6;3;2;6;5;6;4;5;3;6;3;5;4;3;4; K19870 IPR001440;IPR019734;IPR025986;IPR013026;IPR011990; Tetratricopeptide repeat 1;Tetratricopeptide repeat;RNA-polymerase II-associated protein 3-like, C-terminal domain;Tetratricopeptide repeat-containing domain;Tetratricopeptide-like helical domain; cytosol Hs11024639 1903.0 R [R] General function prediction only; Q03591 Complement factor H-related protein 1 OS=Homo sapiens OX=9606 GN=CFHR1 PE=1 SV=2 - [FHR1_HUMAN] 0.646 1.01 1.552 0.827 0.913 0.953 0.63960396 0.015377513 0.905805038 0.050763874 1.536633663 0.073661147 1.04381161 0.191476581 GO:0048584;GO:0048583;GO:0050789;GO:0044699;GO:0044710;GO:0072376;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:0008150;GO:0008152;GO:0006955;GO:0006959;GO:0044238;GO:0050776;GO:0019538;GO:0050896;GO:0050778;GO:0043170;GO:0002376;GO:0002253;GO:0002252;GO:0006956; positive regulation of response to stimulus;regulation of response to stimulus;regulation of biological process;single-organism process;single-organism metabolic process;protein activation cascade;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;biological_process;metabolic process;immune response;humoral immune response;primary metabolic process;regulation of immune response;protein metabolic process;response to stimulus;positive regulation of immune response;macromolecule metabolic process;immune system process;activation of immune response;immune effector process;complement activation; 3;3;2;2;3;3;3;3;3;2;2;1;2;3;4;3;4;4;2;4;4;2;3;3;4; GO:0043227;GO:0005575;GO:1903561;GO:0070062;GO:0005615;GO:0072562;GO:0043226;GO:0031982;GO:0043230;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;extracellular exosome;extracellular space;blood microparticle;organelle;vesicle;extracellular organelle;extracellular region;extracellular region part; 3;1;3;4;3;3;2;4;3;2;2; IPR000436; Sushi/SCR/CCP domain; extracellular Q5M9N0 Coiled-coil domain-containing protein 158 OS=Homo sapiens OX=9606 GN=CCDC158 PE=2 SV=2 - [CD158_HUMAN] 1.057 1.196 0.674 1.214 1.134 1.104 0.883779264 nan 1.070546737 nan 0.563545151 nan 0.973544974 nan IPR031809; Coiled-coil domain-containing protein 158; cytosol, nucleus Q53QZ3 Rho GTPase-activating protein 15 OS=Homo sapiens OX=9606 GN=ARHGAP15 PE=1 SV=2 - [RHG15_HUMAN] 0.618 0.633 2.342 0.804 0.541 0.837 0.976303318 nan 1.486136784 nan 3.699842022 nan 1.547134935 nan GO:0022604;GO:0022603;GO:0048583;GO:0051128;GO:0023052;GO:0007165;GO:0023051;GO:0035556;GO:0010646;GO:0043087;GO:0050789;GO:0044699;GO:0051716;GO:1902531;GO:0043547;GO:0051345;GO:0009966;GO:0048869;GO:0071840;GO:0016043;GO:0032989;GO:0065007;GO:0043085;GO:0044093;GO:0065009;GO:0065008;GO:0032502;GO:0051056;GO:0050790;GO:0050793;GO:0009987;GO:0050794;GO:0044767;GO:0008360;GO:0008150;GO:0007154;GO:0007264;GO:0000902;GO:0051336;GO:0044700;GO:0050896;GO:0048856;GO:0009653;GO:0044763; regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;regulation of response to stimulus;regulation of cellular component organization;signaling;signal transduction;regulation of signaling;intracellular signal transduction;regulation of cell communication;regulation of GTPase activity;regulation of biological process;single-organism process;cellular response to stimulus;regulation of intracellular signal transduction;positive regulation of GTPase activity;positive regulation of hydrolase activity;regulation of signal transduction;cellular developmental process;cellular component organization or biogenesis;cellular component organization;cellular component morphogenesis;biological regulation;positive regulation of catalytic activity;positive regulation of molecular function;regulation of molecular function;regulation of biological quality;developmental process;regulation of small GTPase mediated signal transduction;regulation of catalytic activity;regulation of developmental process;cellular process;regulation of cellular process;single-organism developmental process;regulation of cell shape;biological_process;cell communication;small GTPase mediated signal transduction;cell morphogenesis;regulation of hydrolase activity;single organism signaling;response to stimulus;anatomical structure development;anatomical structure morphogenesis;single-organism cellular process; 5;4;3;4;2;4;3;5;4;6;2;2;3;5;7;6;4;4;2;3;4;2;5;4;3;3;2;6;4;3;2;3;3;4;1;4;6;5;5;3;2;3;3;3; GO:0005737;GO:0016020;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0005829; cytoplasm;membrane;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;cytosol; 4;2;2;2;3;1;4;3;5; GO:0003674;GO:0098772;GO:0030234;GO:0005096;GO:0030695;GO:0060589;GO:0008047; molecular_function;molecular function regulator;enzyme regulator activity;GTPase activator activity;GTPase regulator activity;nucleoside-triphosphatase regulator activity;enzyme activator activity; 1;2;3;5;5;4;4; K20637 IPR008936;IPR000198;IPR001849;IPR011993; Rho GTPase activation protein;Rho GTPase-activating protein domain;Pleckstrin homology domain;PH domain-like; nucleus Hs8922106 483.0 T [T] Signal transduction mechanisms; O95263 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Homo sapiens OX=9606 GN=PDE8B PE=1 SV=2 - [PDE8B_HUMAN] 0.864 1.048 1.016 1.132 1.229 0.786 0.824427481 nan 0.921074044 nan 0.969465649 nan 0.639544345 nan GO:0090087;GO:0008104;GO:0009214;GO:0046434;GO:0051046;GO:0051048;GO:0051049;GO:0009166;GO:0044281;GO:1901360;GO:1901361;GO:0044712;GO:0044710;GO:0046879;GO:0048519;GO:0033036;GO:1903530;GO:0051051;GO:0019439;GO:0045184;GO:0090276;GO:0090278;GO:0046483;GO:0044700;GO:1901564;GO:1901565;GO:0015833;GO:0006163;GO:1903531;GO:0010648;GO:0051716;GO:0032940;GO:0006807;GO:0006198;GO:0051223;GO:0051224;GO:0050789;GO:0030072;GO:0030073;GO:0046700;GO:1901575;GO:0050708;GO:0050709;GO:0065007;GO:0019637;GO:0065008;GO:0009150;GO:0070201;GO:0009154;GO:0009306;GO:0006810;GO:0050796;GO:0050794;GO:0009261;GO:0008150;GO:0008152;GO:0034655;GO:0051234;GO:0046903;GO:0044270;GO:0050896;GO:1901292;GO:0044763;GO:0006753;GO:0023057;GO:0034641;GO:0023052;GO:0046676;GO:0023051;GO:1904950;GO:0010646;GO:0009259;GO:0044699;GO:0032880;GO:0006139;GO:0042886;GO:0044248;GO:0009987;GO:0006725;GO:0046883;GO:0046888;GO:0032879;GO:0055086;GO:1901136;GO:1901135;GO:0009187;GO:0060341;GO:0007165;GO:0019693;GO:0072521;GO:0072523;GO:0006195;GO:0071705;GO:0071704;GO:0071702;GO:0046058;GO:0023061;GO:0010817;GO:0044765;GO:0009117;GO:0007267;GO:0007154;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0002790;GO:0002791;GO:0002792;GO:0044237;GO:0009914;GO:0006796;GO:0006793;GO:0015031;GO:0048523; regulation of peptide transport;protein localization;cyclic nucleotide catabolic process;organophosphate catabolic process;regulation of secretion;negative regulation of secretion;regulation of transport;nucleotide catabolic process;small molecule metabolic process;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism catabolic process;single-organism metabolic process;hormone secretion;negative regulation of biological process;macromolecule localization;regulation of secretion by cell;negative regulation of transport;aromatic compound catabolic process;establishment of protein localization;regulation of peptide hormone secretion;negative regulation of peptide hormone secretion;heterocycle metabolic process;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound catabolic process;peptide transport;purine nucleotide metabolic process;negative regulation of secretion by cell;negative regulation of cell communication;cellular response to stimulus;secretion by cell;nitrogen compound metabolic process;cAMP catabolic process;regulation of protein transport;negative regulation of protein transport;regulation of biological process;peptide hormone secretion;insulin secretion;heterocycle catabolic process;organic substance catabolic process;regulation of protein secretion;negative regulation of protein secretion;biological regulation;organophosphate metabolic process;regulation of biological quality;purine ribonucleotide metabolic process;regulation of establishment of protein localization;purine ribonucleotide catabolic process;protein secretion;transport;regulation of insulin secretion;regulation of cellular process;ribonucleotide catabolic process;biological_process;metabolic process;nucleobase-containing compound catabolic process;establishment of localization;secretion;cellular nitrogen compound catabolic process;response to stimulus;nucleoside phosphate catabolic process;single-organism cellular process;nucleoside phosphate metabolic process;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of insulin secretion;regulation of signaling;negative regulation of establishment of protein localization;regulation of cell communication;ribonucleotide metabolic process;single-organism process;regulation of protein localization;nucleobase-containing compound metabolic process;amide transport;cellular catabolic process;cellular process;cellular aromatic compound metabolic process;regulation of hormone secretion;negative regulation of hormone secretion;regulation of localization;nucleobase-containing small molecule metabolic process;carbohydrate derivative catabolic process;carbohydrate derivative metabolic process;cyclic nucleotide metabolic process;regulation of cellular localization;signal transduction;ribose phosphate metabolic process;purine-containing compound metabolic process;purine-containing compound catabolic process;purine nucleotide catabolic process;nitrogen compound transport;organic substance metabolic process;organic substance transport;cAMP metabolic process;signal release;regulation of hormone levels;single-organism transport;nucleotide metabolic process;cell-cell signaling;cell communication;catabolic process;localization;single-organism localization;cellular localization;primary metabolic process;peptide secretion;regulation of peptide secretion;negative regulation of peptide secretion;cellular metabolic process;hormone transport;phosphate-containing compound metabolic process;phosphorus metabolic process;protein transport;negative regulation of cellular process; 5;4;7;5;5;4;4;6;4;4;5;4;3;6;2;3;5;3;5;4;5;5;4;3;4;5;6;6;4;4;3;4;3;8;5;4;2;7;6;5;4;6;5;2;4;3;7;5;7;5;4;6;3;6;1;2;5;3;5;5;2;5;3;5;3;4;2;6;3;3;4;6;2;4;4;5;4;2;4;4;4;3;4;5;4;7;4;4;5;5;6;7;5;3;5;8;5;4;4;6;4;4;3;2;3;3;3;6;6;5;3;5;5;4;5;3; GO:0005829;GO:0044424;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575; cytosol;intracellular part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;cellular_component; 5;3;4;4;2;2;3;1; GO:0003674;GO:0005488;GO:0008081;GO:0016787;GO:0043169;GO:0016788;GO:0003824;GO:0004114;GO:0004112;GO:0042578;GO:0043167;GO:0046872; molecular_function;binding;phosphoric diester hydrolase activity;hydrolase activity;cation binding;hydrolase activity, acting on ester bonds;catalytic activity;3',5'-cyclic-nucleotide phosphodiesterase activity;cyclic-nucleotide phosphodiesterase activity;phosphoric ester hydrolase activity;ion binding;metal ion binding; 1;2;6;3;4;4;2;8;7;5;3;5; K18437 map00230;map05032; Purine metabolism;Morphine addiction; IPR013938;IPR003607;IPR023088;IPR000014;IPR023174;IPR002073; 3'5'-cyclic nucleotide phosphodiesterase PDE8;HD/PDEase domain;3'5'-cyclic nucleotide phosphodiesterase;PAS domain;3'5'-cyclic nucleotide phosphodiesterase, conserved site;3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; cytosol Hs22051993 1601.0 T [T] Signal transduction mechanisms; Q8N157 Jouberin OS=Homo sapiens OX=9606 GN=AHI1 PE=1 SV=1 - [AHI1_HUMAN] 1.038 1.254 0.904 0.885 1.402 nan 0.827751196 nan 0.631241084 nan 0.720893142 nan nan nan GO:0008104;GO:0080090;GO:0019222;GO:0051049;GO:0048583;GO:0007610;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0010556;GO:1901362;GO:0071840;GO:0051716;GO:0072114;GO:0070727;GO:0048869;GO:0007368;GO:0001822;GO:0044238;GO:0048513;GO:0030856;GO:0030855;GO:0048518;GO:0060993;GO:0030858;GO:0033036;GO:0042384;GO:0039007;GO:0060255;GO:0060548;GO:0051252;GO:0003007;GO:0010628;GO:0048260;GO:0003002;GO:2001141;GO:0016192;GO:0044700;GO:0044707;GO:0009790;GO:0039008;GO:0046530;GO:0035844;GO:0035845;GO:0003407;GO:0019438;GO:0044782;GO:0044710;GO:0048666;GO:0048562;GO:0048565;GO:0034645;GO:0022603;GO:0048568;GO:0008152;GO:0043170;GO:0042981;GO:0050789;GO:0097659;GO:0000902;GO:0044260;GO:0072073;GO:0046483;GO:0070121;GO:0039019;GO:0018130;GO:0016043;GO:0071599;GO:0065001;GO:0065007;GO:0045893;GO:0006366;GO:0048646;GO:0042461;GO:0051130;GO:0009887;GO:0006915;GO:0060322;GO:0060271;GO:0050793;GO:0009889;GO:0009888;GO:0050795;GO:0050794;GO:0051128;GO:0012501;GO:0008150;GO:0051239;GO:0039020;GO:0039022;GO:0039023;GO:0009059;GO:0034613;GO:0010604;GO:0016070;GO:0044271;GO:0007420;GO:0007423;GO:0072028;GO:0050896;GO:0030860;GO:0048793;GO:0006355;GO:0006357;GO:0006351;GO:1901576;GO:0043010;GO:0002092;GO:0032774;GO:0048259;GO:0030154;GO:0010927;GO:0055123;GO:0010842;GO:0034641;GO:0022607;GO:0023052;GO:0060041;GO:0060042;GO:0009799;GO:0009798;GO:0009653;GO:0070986;GO:0022008;GO:0044699;GO:0007417;GO:0006139;GO:0051234;GO:0009891;GO:0001947;GO:0044765;GO:0006810;GO:0031326;GO:0060562;GO:0061371;GO:0009893;GO:0032502;GO:0032501;GO:0035239;GO:0007507;GO:0060429;GO:0006725;GO:1903506;GO:0060627;GO:0045597;GO:0072009;GO:0001654;GO:0001655;GO:0048519;GO:0072001;GO:0032879;GO:0072006;GO:0032990;GO:0048839;GO:0030859;GO:0031623;GO:0051094;GO:0051254;GO:1902680;GO:0072080;GO:0045944;GO:0030862;GO:0048731;GO:0034654;GO:0072088;GO:0048546;GO:0048468;GO:1903508;GO:0006898;GO:0061326;GO:0031328;GO:0030030;GO:0030031;GO:0031325;GO:0031323;GO:0006807;GO:0090304;GO:0072176;GO:0060972;GO:0006897;GO:0072078;GO:0010467;GO:0008219;GO:0010941;GO:0007275;GO:0072178;GO:0002009;GO:1901360;GO:0051050;GO:2000112;GO:0010557;GO:2000027;GO:0071704;GO:0043067;GO:0043066;GO:0043583;GO:0048729;GO:0002090;GO:0043069;GO:0010468;GO:0090596;GO:0048598;GO:0061333;GO:0009987;GO:0045935;GO:0030182;GO:0007389;GO:0019219;GO:0048592;GO:0048593;GO:0035050;GO:0044767;GO:0009058;GO:0001738;GO:0044763;GO:0051171;GO:0051173;GO:0007154;GO:0035295;GO:0070925;GO:0030100;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0003143;GO:0048699;GO:0043112;GO:0048858;GO:0007399;GO:0048856;GO:0045595;GO:0044237;GO:1902589;GO:0044085;GO:2000026;GO:0032989;GO:0030902;GO:0009855;GO:0045807;GO:0048522;GO:0044249;GO:0048523; protein localization;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;regulation of response to stimulus;behavior;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of macromolecule biosynthetic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;pronephros morphogenesis;cellular macromolecule localization;cellular developmental process;determination of left/right symmetry;kidney development;primary metabolic process;animal organ development;regulation of epithelial cell differentiation;epithelial cell differentiation;positive regulation of biological process;kidney morphogenesis;positive regulation of epithelial cell differentiation;macromolecule localization;cilium assembly;pronephric nephron morphogenesis;regulation of macromolecule metabolic process;negative regulation of cell death;regulation of RNA metabolic process;heart morphogenesis;positive regulation of gene expression;positive regulation of receptor-mediated endocytosis;regionalization;regulation of RNA biosynthetic process;vesicle-mediated transport;single organism signaling;single-multicellular organism process;embryo development;pronephric nephron tubule morphogenesis;photoreceptor cell differentiation;cloaca development;photoreceptor cell outer segment organization;neural retina development;aromatic compound biosynthetic process;cilium organization;single-organism metabolic process;neuron development;embryonic organ morphogenesis;digestive tract development;cellular macromolecule biosynthetic process;regulation of anatomical structure morphogenesis;embryonic organ development;metabolic process;macromolecule metabolic process;regulation of apoptotic process;regulation of biological process;nucleic acid-templated transcription;cell morphogenesis;cellular macromolecule metabolic process;kidney epithelium development;heterocycle metabolic process;Kupffer's vesicle development;pronephric nephron development;heterocycle biosynthetic process;cellular component organization;otic vesicle development;specification of axis polarity;biological regulation;positive regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter;anatomical structure formation involved in morphogenesis;photoreceptor cell development;positive regulation of cellular component organization;organ morphogenesis;apoptotic process;head development;cilium morphogenesis;regulation of developmental process;regulation of biosynthetic process;tissue development;regulation of behavior;regulation of cellular process;regulation of cellular component organization;programmed cell death;biological_process;regulation of multicellular organismal process;pronephric nephron tubule development;pronephric duct development;pronephric duct morphogenesis;macromolecule biosynthetic process;cellular protein localization;positive regulation of macromolecule metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;brain development;sensory organ development;nephron morphogenesis;response to stimulus;regulation of polarized epithelial cell differentiation;pronephros development;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;organic substance biosynthetic process;camera-type eye development;positive regulation of receptor internalization;RNA biosynthetic process;regulation of receptor-mediated endocytosis;cell differentiation;cellular component assembly involved in morphogenesis;digestive system development;retina layer formation;cellular nitrogen compound metabolic process;cellular component assembly;signaling;retina development in camera-type eye;retina morphogenesis in camera-type eye;specification of symmetry;axis specification;anatomical structure morphogenesis;left/right axis specification;neurogenesis;single-organism process;central nervous system development;nucleobase-containing compound metabolic process;establishment of localization;positive regulation of biosynthetic process;heart looping;single-organism transport;transport;regulation of cellular biosynthetic process;epithelial tube morphogenesis;determination of heart left/right asymmetry;positive regulation of metabolic process;developmental process;multicellular organismal process;tube morphogenesis;heart development;epithelium development;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of vesicle-mediated transport;positive regulation of cell differentiation;nephron epithelium development;eye development;urogenital system development;negative regulation of biological process;renal system development;regulation of localization;nephron development;cell part morphogenesis;inner ear development;polarized epithelial cell differentiation;receptor internalization;positive regulation of developmental process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;nephron tubule development;positive regulation of transcription from RNA polymerase II promoter;positive regulation of polarized epithelial cell differentiation;system development;nucleobase-containing compound biosynthetic process;nephron epithelium morphogenesis;digestive tract morphogenesis;cell development;positive regulation of nucleic acid-templated transcription;receptor-mediated endocytosis;renal tubule development;positive regulation of cellular biosynthetic process;cell projection organization;cell projection assembly;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nitrogen compound metabolic process;nucleic acid metabolic process;nephric duct development;left/right pattern formation;endocytosis;nephron tubule morphogenesis;gene expression;cell death;regulation of cell death;multicellular organism development;nephric duct morphogenesis;morphogenesis of an epithelium;organic cyclic compound metabolic process;positive regulation of transport;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;regulation of organ morphogenesis;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;ear development;tissue morphogenesis;regulation of receptor internalization;negative regulation of programmed cell death;regulation of gene expression;sensory organ morphogenesis;embryonic morphogenesis;renal tubule morphogenesis;cellular process;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;pattern specification process;regulation of nucleobase-containing compound metabolic process;eye morphogenesis;camera-type eye morphogenesis;embryonic heart tube development;single-organism developmental process;biosynthetic process;morphogenesis of a polarized epithelium;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;tube development;organelle assembly;regulation of endocytosis;localization;single-organism localization;cellular localization;organelle organization;embryonic heart tube morphogenesis;generation of neurons;receptor metabolic process;cell projection morphogenesis;nervous system development;anatomical structure development;regulation of cell differentiation;cellular metabolic process;single-organism organelle organization;cellular component biogenesis;regulation of multicellular organismal development;cellular component morphogenesis;hindbrain development;determination of bilateral symmetry;positive regulation of endocytosis;positive regulation of cellular process;cellular biosynthetic process;negative regulation of cellular process; 4;4;3;4;3;2;5;5;4;5;6;7;5;5;2;3;6;4;4;7;4;3;4;5;6;2;5;5;3;5;5;4;4;5;5;5;5;5;6;5;3;3;5;6;7;4;6;4;5;5;3;5;5;4;5;4;4;2;4;6;2;7;5;4;5;4;4;5;5;3;5;5;2;6;7;3;6;4;4;6;4;6;3;4;4;3;3;4;5;1;3;6;6;7;5;5;4;5;5;4;4;4;2;6;5;6;7;6;4;6;5;6;6;5;4;5;4;4;4;2;4;5;5;5;3;6;6;2;5;4;3;4;6;4;4;5;5;5;3;2;2;4;4;5;4;7;4;4;5;5;5;2;5;3;4;5;4;7;4;3;5;6;6;7;6;4;5;5;5;4;7;7;5;5;4;5;4;4;3;5;5;6;6;6;5;4;4;4;6;5;4;3;6;5;5;3;5;6;5;4;5;5;5;5;4;6;2;5;6;4;5;6;7;5;3;3;6;3;4;4;4;4;5;5;2;3;3;4;5;7;5;5;5;3;4;3;4;3;4;4;4;6;4;3;4;3; GO:0005815;GO:0031513;GO:0036038;GO:0042995;GO:0043234;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0015630;GO:0005929;GO:0005856;GO:0036064;GO:0044430;GO:0030054;GO:0070161;GO:0035869;GO:0044446;GO:0044444;GO:0044441;GO:0005737;GO:0044450;GO:0005911;GO:0032991;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0072372;GO:0005813;GO:0005814;GO:0043226;GO:0043228;GO:0005575;GO:0005912; microtubule organizing center;nonmotile primary cilium;TCTN-B9D complex;cell projection;protein complex;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;microtubule cytoskeleton;cilium;cytoskeleton;ciliary basal body;cytoskeletal part;cell junction;anchoring junction;ciliary transition zone;intracellular organelle part;cytoplasmic part;ciliary part;cytoplasm;microtubule organizing center part;cell-cell junction;macromolecular complex;cell projection part;cell part;cell;intracellular;primary cilium;centrosome;centriole;organelle;non-membrane-bounded organelle;cellular_component;adherens junction; 5;5;4;3;3;4;5;3;2;3;6;3;5;4;4;2;3;4;3;4;3;4;5;3;2;3;2;2;3;4;5;5;2;3;1;4; GO:0003674;GO:0005488;GO:0042802;GO:0005515; molecular_function;binding;identical protein binding;protein binding; 1;2;4;3; K16740 IPR001452;IPR017986;IPR015943;IPR001680; SH3 domain;WD40-repeat-containing domain;WD40/YVTN repeat-like-containing domain;WD40 repeat; nucleus Hs21361641 2497.0 R [R] General function prediction only; Q9Y4E8 Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3 - [UBP15_HUMAN] 1.274 0.951 0.824 1.187 0.844 1.564 1.339642482 nan 1.406398104 nan 0.866456362 nan 1.853080569 nan GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0030509;GO:0007165;GO:0007166;GO:0007167;GO:1901362;GO:0071840;GO:0051716;GO:0009968;GO:0009966;GO:0070647;GO:0070848;GO:0030512;GO:0048519;GO:0046483;GO:0010467;GO:0060255;GO:0030163;GO:2001141;GO:0010033;GO:0007179;GO:0007178;GO:0044700;GO:0023057;GO:0019538;GO:0010468;GO:0019438;GO:0016568;GO:0016569;GO:0034645;GO:0023051;GO:0090092;GO:0006807;GO:0050789;GO:0097659;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0090101;GO:0060389;GO:0016043;GO:0065007;GO:0016570;GO:0006366;GO:0016579;GO:0016578;GO:0018130;GO:0009719;GO:0017015;GO:0009889;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0051603;GO:0044271;GO:0050896;GO:0006355;GO:0006357;GO:0006351;GO:0006511;GO:0071772;GO:0071773;GO:0032774;GO:0016310;GO:0070646;GO:0044248;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0070887;GO:0007154;GO:0010646;GO:0044699;GO:0006139;GO:0090287;GO:0090288;GO:0006508;GO:0071495;GO:0009987;GO:0006725;GO:1903506;GO:0035520;GO:0044257;GO:0071363;GO:0051252;GO:0043170;GO:0071560;GO:0043933;GO:0031326;GO:0031323;GO:0090304;GO:0043632;GO:1903845;GO:1903844;GO:0006325;GO:1901360;GO:2000112;GO:0006796;GO:0071704;GO:0071310;GO:0010556;GO:0071559;GO:0006468;GO:1901576;GO:0019219;GO:0019941;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0042221;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:1902589;GO:0006793;GO:0035616;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;BMP signaling pathway;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;protein modification by small protein conjugation or removal;response to growth factor;negative regulation of transforming growth factor beta receptor signaling pathway;negative regulation of biological process;heterocycle metabolic process;gene expression;regulation of macromolecule metabolic process;protein catabolic process;regulation of RNA biosynthetic process;response to organic substance;transforming growth factor beta receptor signaling pathway;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;negative regulation of signaling;protein metabolic process;regulation of gene expression;aromatic compound biosynthetic process;chromatin modification;covalent chromatin modification;cellular macromolecule biosynthetic process;regulation of signaling;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;pathway-restricted SMAD protein phosphorylation;cellular component organization;biological regulation;histone modification;transcription from RNA polymerase II promoter;protein deubiquitination;histone deubiquitination;heterocycle biosynthetic process;response to endogenous stimulus;regulation of transforming growth factor beta receptor signaling pathway;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;proteolysis involved in cellular protein catabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;ubiquitin-dependent protein catabolic process;response to BMP;cellular response to BMP stimulus;RNA biosynthetic process;phosphorylation;protein modification by small protein removal;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular response to chemical stimulus;cell communication;regulation of cell communication;single-organism process;nucleobase-containing compound metabolic process;regulation of cellular response to growth factor stimulus;negative regulation of cellular response to growth factor stimulus;proteolysis;cellular response to endogenous stimulus;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;monoubiquitinated protein deubiquitination;cellular protein catabolic process;cellular response to growth factor stimulus;regulation of RNA metabolic process;macromolecule metabolic process;cellular response to transforming growth factor beta stimulus;macromolecular complex subunit organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;modification-dependent macromolecule catabolic process;negative regulation of cellular response to transforming growth factor beta stimulus;regulation of cellular response to transforming growth factor beta stimulus;chromatin organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;phosphate-containing compound metabolic process;organic substance metabolic process;cellular response to organic substance;regulation of macromolecule biosynthetic process;response to transforming growth factor beta;protein phosphorylation;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;modification-dependent protein catabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;response to chemical;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;single-organism organelle organization;phosphorus metabolic process;histone H2B conserved C-terminal lysine deubiquitination;negative regulation of cellular process; 4;3;3;3;6;4;5;6;5;2;3;4;4;7;5;6;2;4;5;4;5;6;4;6;7;3;3;4;5;5;6;7;5;3;5;3;2;7;5;4;5;4;5;8;3;2;4;7;7;5;5;3;6;4;3;3;5;5;1;2;5;5;6;5;2;6;7;6;8;4;5;6;6;6;4;4;4;2;4;4;4;4;2;4;4;4;5;4;2;4;7;8;6;6;5;4;5;4;5;4;5;6;5;5;5;4;6;5;3;5;5;4;7;4;5;7;6;3;5;3;4;3;3;5;4;3;5;3;4;4;6;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasm;nucleus;cell part;cell;organelle;cellular_component; 4;3;3;3;3;4;5;2;2;2;1; GO:0046332;GO:0005126;GO:0042393;GO:0016787;GO:0003674;GO:0005488;GO:0003824;GO:0036459;GO:0101005;GO:0008233;GO:0008234;GO:0019783;GO:0004843;GO:0042802;GO:0004197;GO:0005515;GO:0005102;GO:0004175;GO:0005160;GO:0061649;GO:0070011; SMAD binding;cytokine receptor binding;histone binding;hydrolase activity;molecular_function;binding;catalytic activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitinyl hydrolase activity;peptidase activity;cysteine-type peptidase activity;ubiquitin-like protein-specific protease activity;thiol-dependent ubiquitin-specific protease activity;identical protein binding;cysteine-type endopeptidase activity;protein binding;receptor binding;endopeptidase activity;transforming growth factor beta receptor binding;ubiquitinated histone binding;peptidase activity, acting on L-amino acid peptides; 4;5;4;3;1;2;2;5;4;4;6;7;6;4;7;3;4;6;6;5;5; K21343 IPR013792;IPR006615;IPR029071;IPR018200;IPR001394;IPR028135;IPR028889;IPR029346; RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta;Peptidase C19, ubiquitin-specific peptidase, DUSP domain;Ubiquitin-related domain;Ubiquitin specific protease, conserved site;Peptidase C19, ubiquitin carboxyl-terminal hydrolase;Ubiquitin-like domain, USP-type;Ubiquitin specific protease domain;Ubiquitin carboxyl-terminal hydrolase, C-terminal; cytosol Hs14149627 1977.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9HBL7 Plasminogen receptor (KT) OS=Homo sapiens OX=9606 GN=PLGRKT PE=1 SV=1 - [PLRKT_HUMAN] nan nan nan nan nan nan nan 0.485906701 nan 0.258765268 nan 0.440229947 nan 0.000972561 GO:0080090;GO:0019222;GO:0031639;GO:0031325;GO:0031323;GO:0031638;GO:0008152;GO:0010628;GO:0030162;GO:0050789;GO:0009893;GO:0044267;GO:0010604;GO:0044260;GO:0051246;GO:0051247;GO:0071704;GO:0010467;GO:0032270;GO:0048518;GO:0065007;GO:0010468;GO:0006935;GO:0060255;GO:0009987;GO:0050794;GO:0006952;GO:0006950;GO:0070613;GO:0008150;GO:0006954;GO:0006508;GO:0016485;GO:0042221;GO:0009605;GO:0010954;GO:0040011;GO:0044238;GO:0032268;GO:0051604;GO:0019538;GO:0050896;GO:0042330;GO:0044237;GO:0043170;GO:1903319;GO:0010756;GO:0010755;GO:0045862;GO:1903317;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;plasminogen activation;positive regulation of cellular metabolic process;regulation of cellular metabolic process;zymogen activation;metabolic process;positive regulation of gene expression;regulation of proteolysis;regulation of biological process;positive regulation of metabolic process;cellular protein metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;organic substance metabolic process;gene expression;positive regulation of cellular protein metabolic process;positive regulation of biological process;biological regulation;regulation of gene expression;chemotaxis;regulation of macromolecule metabolic process;cellular process;regulation of cellular process;defense response;response to stress;regulation of protein processing;biological_process;inflammatory response;proteolysis;protein processing;response to chemical;response to external stimulus;positive regulation of protein processing;locomotion;primary metabolic process;regulation of cellular protein metabolic process;protein maturation;protein metabolic process;response to stimulus;taxis;cellular metabolic process;macromolecule metabolic process;positive regulation of protein maturation;positive regulation of plasminogen activation;regulation of plasminogen activation;positive regulation of proteolysis;regulation of protein maturation;positive regulation of cellular process; 4;3;8;4;4;7;2;5;6;2;3;5;4;4;5;5;3;5;5;2;2;5;4;4;2;3;4;3;7;1;5;5;6;3;3;7;2;3;5;5;4;2;3;3;4;6;8;8;6;6;3; GO:0005886;GO:0043229;GO:0005623;GO:0005887;GO:0043227;GO:0031224;GO:0005737;GO:0031226;GO:0016021;GO:0016020;GO:0005739;GO:0043226;GO:0044425;GO:0044459;GO:0005622;GO:0043231;GO:0044464;GO:0005575;GO:0044444;GO:0071944;GO:0044424; plasma membrane;intracellular organelle;cell;integral component of plasma membrane;membrane-bounded organelle;intrinsic component of membrane;cytoplasm;intrinsic component of plasma membrane;integral component of membrane;membrane;mitochondrion;organelle;membrane part;plasma membrane part;intracellular;intracellular membrane-bounded organelle;cell part;cellular_component;cytoplasmic part;cell periphery;intracellular part; 3;3;2;4;3;3;4;4;4;2;5;2;2;3;3;4;2;1;4;3;3; IPR019319; Protein of unknown function DUF2368; cytosol Hs8923932 294.0 S [S] Function unknown; O96028 Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1 - [NSD2_HUMAN] 0.87 0.908 0.652 2.044 0.773 1.786 0.95814978 nan 2.644243208 nan 0.718061674 nan 2.310478655 nan GO:0006479;GO:0008104;GO:0002706;GO:0080090;GO:0019222;GO:0002312;GO:0048584;GO:0048583;GO:0001501;GO:0072359;GO:0072358;GO:0002703;GO:0002700;GO:2001032;GO:0002381;GO:1901362;GO:1901360;GO:0002708;GO:0051716;GO:0006303;GO:0006302;GO:0002263;GO:0002208;GO:0018193;GO:0045830;GO:0048296;GO:0048513;GO:0048290;GO:0048518;GO:0048519;GO:0048298;GO:0019724;GO:0051054;GO:0006282;GO:0051052;GO:0006281;GO:0060255;GO:0002824;GO:0002822;GO:0003290;GO:0002821;GO:0003007;GO:0050865;GO:0046649;GO:2001141;GO:2001020;GO:0016447;GO:0046483;GO:0016570;GO:0044707;GO:0019538;GO:0002705;GO:0002376;GO:0002377;GO:0002891;GO:0033554;GO:0050778;GO:0060413;GO:0060412;GO:0060411;GO:0016445;GO:0016444;GO:0002702;GO:0033036;GO:0003289;GO:0009893;GO:0009890;GO:0018022;GO:0070201;GO:0003284;GO:0045191;GO:0045190;GO:0003281;GO:0003283;GO:0000018;GO:0002712;GO:0045321;GO:0010629;GO:0006807;GO:0050789;GO:0097659;GO:0003205;GO:1901576;GO:0003206;GO:0002285;GO:0003209;GO:0016043;GO:0002684;GO:0002366;GO:0065007;GO:0071840;GO:0006366;GO:0002200;GO:0032259;GO:0002204;GO:0018130;GO:0009887;GO:0006139;GO:0050793;GO:0003285;GO:0051240;GO:0009889;GO:0044710;GO:0050794;GO:0006950;GO:0051249;GO:0008150;GO:0008152;GO:0019438;GO:0003230;GO:0003231;GO:0051234;GO:0010604;GO:0016070;GO:1902679;GO:0002562;GO:0044271;GO:0002889;GO:0043412;GO:0080134;GO:0080135;GO:0001775;GO:0006355;GO:0002697;GO:0006357;GO:0006351;GO:0002714;GO:0016569;GO:0002699;GO:0010558;GO:0032774;GO:0018205;GO:0006955;GO:0002819;GO:0044249;GO:0034641;GO:0034645;GO:0002696;GO:0051276;GO:0009892;GO:0009653;GO:0044699;GO:0032880;GO:0016064;GO:0043414;GO:0000726;GO:0000725;GO:0000122;GO:0043933;GO:0034968;GO:0036211;GO:0050864;GO:0016571;GO:0002520;GO:0050867;GO:0032502;GO:0006310;GO:0002637;GO:0032501;GO:0007507;GO:0045184;GO:0009987;GO:0006725;GO:0045911;GO:1903506;GO:1903507;GO:0006974;GO:0010605;GO:0045892;GO:0032879;GO:0002639;GO:0003279;GO:0008213;GO:0050776;GO:0002460;GO:0051094;GO:0051251;GO:0051253;GO:0051252;GO:0043170;GO:0051239;GO:2000779;GO:0048731;GO:0050896;GO:0003149;GO:0016568;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0042113;GO:0060348;GO:0090304;GO:0007275;GO:0002682;GO:0002694;GO:0006325;GO:2000112;GO:2000113;GO:0002443;GO:0071704;GO:0010467;GO:0010556;GO:0000724;GO:0010468;GO:0045935;GO:0045934;GO:0044267;GO:0019219;GO:0006464;GO:0044767;GO:0002449;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0002440;GO:0050871;GO:0051179;GO:0006996;GO:0044238;GO:0044260;GO:0010452;GO:0048856;GO:0044237;GO:1902589;GO:2000026;GO:0002250;GO:0002252;GO:0006259;GO:0034654;GO:0048523;GO:0048522; protein methylation;protein localization;regulation of lymphocyte mediated immunity;regulation of primary metabolic process;regulation of metabolic process;B cell activation involved in immune response;positive regulation of response to stimulus;regulation of response to stimulus;skeletal system development;circulatory system development;cardiovascular system development;regulation of leukocyte mediated immunity;regulation of production of molecular mediator of immune response;regulation of double-strand break repair via nonhomologous end joining;immunoglobulin production involved in immunoglobulin mediated immune response;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of lymphocyte mediated immunity;cellular response to stimulus;double-strand break repair via nonhomologous end joining;double-strand break repair;cell activation involved in immune response;somatic diversification of immunoglobulins involved in immune response;peptidyl-amino acid modification;positive regulation of isotype switching;regulation of isotype switching to IgA isotypes;animal organ development;isotype switching to IgA isotypes;positive regulation of biological process;negative regulation of biological process;positive regulation of isotype switching to IgA isotypes;B cell mediated immunity;positive regulation of DNA metabolic process;regulation of DNA repair;regulation of DNA metabolic process;DNA repair;regulation of macromolecule metabolic process;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;atrial septum secundum morphogenesis;positive regulation of adaptive immune response;heart morphogenesis;regulation of cell activation;lymphocyte activation;regulation of RNA biosynthetic process;regulation of response to DNA damage stimulus;somatic recombination of immunoglobulin gene segments;heterocycle metabolic process;histone modification;single-multicellular organism process;protein metabolic process;positive regulation of leukocyte mediated immunity;immune system process;immunoglobulin production;positive regulation of immunoglobulin mediated immune response;cellular response to stress;positive regulation of immune response;atrial septum morphogenesis;ventricular septum morphogenesis;cardiac septum morphogenesis;somatic diversification of immunoglobulins;somatic cell DNA recombination;positive regulation of production of molecular mediator of immune response;macromolecule localization;atrial septum primum morphogenesis;positive regulation of metabolic process;negative regulation of biosynthetic process;peptidyl-lysine methylation;regulation of establishment of protein localization;septum primum development;regulation of isotype switching;isotype switching;ventricular septum development;atrial septum development;regulation of DNA recombination;regulation of B cell mediated immunity;leukocyte activation;negative regulation of gene expression;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;cardiac chamber development;organic substance biosynthetic process;cardiac chamber morphogenesis;lymphocyte activation involved in immune response;cardiac atrium morphogenesis;cellular component organization;positive regulation of immune system process;leukocyte activation involved in immune response;biological regulation;cellular component organization or biogenesis;transcription from RNA polymerase II promoter;somatic diversification of immune receptors;methylation;somatic recombination of immunoglobulin genes involved in immune response;heterocycle biosynthetic process;organ morphogenesis;nucleobase-containing compound metabolic process;regulation of developmental process;septum secundum development;positive regulation of multicellular organismal process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;response to stress;regulation of lymphocyte activation;biological_process;metabolic process;aromatic compound biosynthetic process;cardiac atrium development;cardiac ventricle development;establishment of localization;positive regulation of macromolecule metabolic process;RNA metabolic process;negative regulation of RNA biosynthetic process;somatic diversification of immune receptors via germline recombination within a single locus;cellular nitrogen compound biosynthetic process;regulation of immunoglobulin mediated immune response;macromolecule modification;regulation of response to stress;regulation of cellular response to stress;cell activation;regulation of transcription, DNA-templated;regulation of immune effector process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;positive regulation of B cell mediated immunity;covalent chromatin modification;positive regulation of immune effector process;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;peptidyl-lysine modification;immune response;regulation of adaptive immune response;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;positive regulation of leukocyte activation;chromosome organization;negative regulation of metabolic process;anatomical structure morphogenesis;single-organism process;regulation of protein localization;immunoglobulin mediated immune response;macromolecule methylation;non-recombinational repair;recombinational repair;negative regulation of transcription from RNA polymerase II promoter;macromolecular complex subunit organization;histone lysine methylation;protein modification process;regulation of B cell activation;histone methylation;immune system development;positive regulation of cell activation;developmental process;DNA recombination;regulation of immunoglobulin production;multicellular organismal process;heart development;establishment of protein localization;cellular process;cellular aromatic compound metabolic process;positive regulation of DNA recombination;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;negative regulation of macromolecule metabolic process;negative regulation of transcription, DNA-templated;regulation of localization;positive regulation of immunoglobulin production;cardiac septum development;protein alkylation;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of developmental process;positive regulation of lymphocyte activation;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;regulation of multicellular organismal process;regulation of double-strand break repair;system development;response to stimulus;membranous septum morphogenesis;chromatin modification;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;B cell activation;bone development;nucleic acid metabolic process;multicellular organism development;regulation of immune system process;regulation of leukocyte activation;chromatin organization;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;leukocyte mediated immunity;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;double-strand break repair via homologous recombination;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism developmental process;lymphocyte mediated immunity;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;production of molecular mediator of immune response;positive regulation of B cell activation;localization;organelle organization;primary metabolic process;cellular macromolecule metabolic process;histone H3-K36 methylation;anatomical structure development;cellular metabolic process;single-organism organelle organization;regulation of multicellular organismal development;adaptive immune response;immune effector process;DNA metabolic process;nucleobase-containing compound biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 5;4;6;4;3;4;3;3;5;5;5;5;4;7;5;5;4;6;3;6;5;4;5;7;4;6;4;5;2;2;5;6;5;5;5;4;4;6;6;6;5;5;4;4;6;5;5;4;4;3;4;5;2;4;8;4;4;5;5;4;4;7;4;3;6;3;4;6;5;6;5;4;5;5;6;7;3;5;3;2;7;4;4;4;4;5;3;3;4;2;2;7;3;3;6;5;4;4;3;6;3;4;3;3;3;5;1;2;5;5;5;3;4;5;6;4;5;8;5;4;4;4;6;4;7;6;7;7;4;5;6;8;3;5;4;4;5;4;5;3;3;2;4;7;4;5;5;7;4;6;5;6;5;3;4;2;6;5;2;4;4;2;4;6;7;7;5;4;6;3;5;4;7;4;5;3;5;5;5;4;3;6;4;2;4;6;5;5;4;4;4;5;4;5;4;3;4;5;6;6;4;3;5;5;6;5;5;5;5;5;6;3;5;3;5;3;4;4;4;3;6;2;4;3;4;7;3;3;4;4;4;3;5;5;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044422;GO:0043232;GO:0005622;GO:0043227;GO:0005654;GO:0044424;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0043228;GO:0043226;GO:0005694;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;organelle part;intracellular non-membrane-bounded organelle;intracellular;membrane-bounded organelle;nucleoplasm;intracellular part;intracellular organelle part;cytoplasm;nucleus;cell part;intracellular organelle;cell;non-membrane-bounded organelle;organelle;chromosome;cellular_component;intracellular organelle lumen; 2;5;4;3;4;2;4;3;3;5;3;3;4;5;2;3;2;3;2;5;1;4; GO:0008270;GO:1901363;GO:0016740;GO:0046872;GO:0044877;GO:0008276;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0008168;GO:0046914;GO:0003824;GO:0097159;GO:0018024;GO:0042054;GO:0043169;GO:0043565;GO:0043167;GO:0016741;GO:0016278;GO:0042799;GO:0003682;GO:0008757;GO:0016279;GO:0008170; zinc ion binding;heterocyclic compound binding;transferase activity;metal ion binding;macromolecular complex binding;protein methyltransferase activity;molecular_function;binding;nucleic acid binding;DNA binding;methyltransferase activity;transition metal ion binding;catalytic activity;organic cyclic compound binding;histone-lysine N-methyltransferase activity;histone methyltransferase activity;cation binding;sequence-specific DNA binding;ion binding;transferase activity, transferring one-carbon groups;lysine N-methyltransferase activity;histone methyltransferase activity (H4-K20 specific);chromatin binding;S-adenosylmethionine-dependent methyltransferase activity;protein-lysine N-methyltransferase activity;N-methyltransferase activity; 7;3;3;5;3;6;1;2;4;5;5;6;2;3;8;7;4;6;3;4;7;9;4;6;7;6; K11424 map00310;map05202; Lysine degradation;Transcriptional misregulation in cancer; IPR019787;IPR009071;IPR000313;IPR011011;IPR006560;IPR003616;IPR013083;IPR001214;IPR001965;IPR001841;IPR019786; Zinc finger, PHD-finger;High mobility group box domain;PWWP domain;Zinc finger, FYVE/PHD-type;AWS domain;Post-SET domain;Zinc finger, RING/FYVE/PHD-type;SET domain;Zinc finger, PHD-type;Zinc finger, RING-type;Zinc finger, PHD-type, conserved site; nucleus Hs19913348 2835.0 K [K] Transcription; P06702 Protein S100-A9 OS=Homo sapiens OX=9606 GN=S100A9 PE=1 SV=1 - [S10A9_HUMAN] 1.038 0.945 1.001 1.259 0.888 1.368 1.098412698 nan 1.417792793 nan 1.059259259 nan 1.540540541 nan GO:0007599;GO:0051046;GO:0051047;GO:0051049;GO:0007596;GO:0098771;GO:0051716;GO:0043207;GO:0051493;GO:0030595;GO:0030593;GO:0032101;GO:0048468;GO:0050832;GO:0046483;GO:0009607;GO:0009605;GO:0019538;GO:0009893;GO:0009891;GO:0035556;GO:0050789;GO:0051345;GO:0006882;GO:1901360;GO:0018130;GO:0098602;GO:0098609;GO:0048708;GO:0043412;GO:0002523;GO:0016070;GO:0010557;GO:0010556;GO:0048869;GO:0044802;GO:0051128;GO:0010001;GO:0035606;GO:0050878;GO:0006875;GO:0006873;GO:0001558;GO:0098542;GO:0061041;GO:0045927;GO:1990266;GO:0097190;GO:0030036;GO:0097193;GO:0042592;GO:0050900;GO:0008219;GO:0007275;GO:2000116;GO:2000112;GO:0043065;GO:0043067;GO:0043068;GO:0019219;GO:0045087;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0010950;GO:0010952;GO:0040011;GO:0048856;GO:0006417;GO:0006412;GO:0048522;GO:0031349;GO:0007009;GO:0007165;GO:0031347;GO:0050729;GO:0010256;GO:0050727;GO:0044093;GO:0006935;GO:0051050;GO:2001141;GO:0051707;GO:0051704;GO:0044707;GO:0050820;GO:0006807;GO:0044267;GO:0046916;GO:0043085;GO:0050790;GO:0009889;GO:0017014;GO:0050794;GO:0051239;GO:0051238;GO:0051235;GO:0051234;GO:0051336;GO:0050896;GO:0006518;GO:0032103;GO:0033043;GO:0070887;GO:0044699;GO:0051240;GO:0051246;GO:0051247;GO:2001244;GO:1903034;GO:1903036;GO:2001242;GO:0034248;GO:1902680;GO:0051674;GO:0048731;GO:0016337;GO:0010604;GO:0097202;GO:0031532;GO:0042981;GO:0071621;GO:0045113;GO:0045935;GO:0030029;GO:0052547;GO:0052548;GO:0018119;GO:0070488;GO:0055065;GO:0007267;GO:0042221;GO:0022008;GO:0055069;GO:0006996;GO:0044238;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:0090087;GO:2001235;GO:0019222;GO:2001233;GO:0048584;GO:0048583;GO:0060326;GO:1901362;GO:0071840;GO:0009966;GO:0009967;GO:0048518;GO:0043604;GO:0032268;GO:0044700;GO:1901564;GO:1901566;GO:0002376;GO:0006928;GO:0097659;GO:0045112;GO:1900046;GO:0016477;GO:1900048;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0006954;GO:0006955;GO:0034654;GO:1902533;GO:1902531;GO:0050818;GO:0018198;GO:0046903;GO:0044271;GO:0051604;GO:0080134;GO:0006355;GO:0006351;GO:0032774;GO:0030154;GO:0015833;GO:0006139;GO:0032270;GO:0097530;GO:0006508;GO:0032502;GO:0032501;GO:0009987;GO:0032119;GO:1903506;GO:0016485;GO:0032879;GO:0051252;GO:0051254;GO:0001816;GO:0032602;GO:2001056;GO:0031638;GO:0071705;GO:0071704;GO:0071702;GO:0006919;GO:0006914;GO:0006915;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0051179;GO:1902578;GO:1902589;GO:0080090;GO:0061024;GO:0055076;GO:0042330;GO:0010608;GO:0009617;GO:0043043;GO:0009611;GO:0018193;GO:0043281;GO:0043280;GO:0019725;GO:0060255;GO:0030162;GO:0048870;GO:0048878;GO:0030193;GO:0019438;GO:0030194;GO:0021782;GO:0042742;GO:1901576;GO:0016049;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:0042063;GO:0042060;GO:0036211;GO:0008150;GO:1903729;GO:0008152;GO:0014002;GO:0030307;GO:0050801;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0007417;GO:0072507;GO:0042886;GO:0070486;GO:0072503;GO:0022610;GO:0045893;GO:0030003;GO:0055080;GO:0055082;GO:0051092;GO:0051091;GO:0051090;GO:0043603;GO:0043170;GO:0010628;GO:0009620;GO:0045862;GO:0097529;GO:1903508;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0090303;GO:0010942;GO:0010941;GO:0040007;GO:0040008;GO:0010467;GO:0010468;GO:0006725;GO:0007159;GO:0007155;GO:0007154;GO:0007010;GO:0044260;GO:0007399; hemostasis;regulation of secretion;positive regulation of secretion;regulation of transport;blood coagulation;inorganic ion homeostasis;cellular response to stimulus;response to external biotic stimulus;regulation of cytoskeleton organization;leukocyte chemotaxis;neutrophil chemotaxis;regulation of response to external stimulus;cell development;defense response to fungus;heterocycle metabolic process;response to biotic stimulus;response to external stimulus;protein metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;intracellular signal transduction;regulation of biological process;positive regulation of hydrolase activity;cellular zinc ion homeostasis;organic cyclic compound metabolic process;heterocycle biosynthetic process;single organism cell adhesion;cell-cell adhesion;astrocyte differentiation;macromolecule modification;leukocyte migration involved in inflammatory response;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;cellular developmental process;single-organism membrane organization;regulation of cellular component organization;glial cell differentiation;peptidyl-cysteine S-trans-nitrosylation;regulation of body fluid levels;cellular metal ion homeostasis;cellular ion homeostasis;regulation of cell growth;defense response to other organism;regulation of wound healing;positive regulation of growth;neutrophil migration;apoptotic signaling pathway;actin cytoskeleton organization;intrinsic apoptotic signaling pathway;homeostatic process;leukocyte migration;cell death;multicellular organism development;regulation of cysteine-type endopeptidase activity;regulation of cellular macromolecule biosynthetic process;positive regulation of apoptotic process;regulation of programmed cell death;positive regulation of programmed cell death;regulation of nucleobase-containing compound metabolic process;innate immune response;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;positive regulation of endopeptidase activity;positive regulation of peptidase activity;locomotion;anatomical structure development;regulation of translation;translation;positive regulation of cellular process;positive regulation of defense response;plasma membrane organization;signal transduction;regulation of defense response;positive regulation of inflammatory response;endomembrane system organization;regulation of inflammatory response;positive regulation of molecular function;chemotaxis;positive regulation of transport;regulation of RNA biosynthetic process;response to other organism;multi-organism process;single-multicellular organism process;positive regulation of coagulation;nitrogen compound metabolic process;cellular protein metabolic process;cellular transition metal ion homeostasis;positive regulation of catalytic activity;regulation of catalytic activity;regulation of biosynthetic process;protein nitrosylation;regulation of cellular process;regulation of multicellular organismal process;sequestering of metal ion;maintenance of location;establishment of localization;regulation of hydrolase activity;response to stimulus;peptide metabolic process;positive regulation of response to external stimulus;regulation of organelle organization;cellular response to chemical stimulus;single-organism process;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of intrinsic apoptotic signaling pathway;regulation of response to wounding;positive regulation of response to wounding;regulation of intrinsic apoptotic signaling pathway;regulation of cellular amide metabolic process;positive regulation of RNA biosynthetic process;localization of cell;system development;single organismal cell-cell adhesion;positive regulation of macromolecule metabolic process;activation of cysteine-type endopeptidase activity;actin cytoskeleton reorganization;regulation of apoptotic process;granulocyte chemotaxis;regulation of integrin biosynthetic process;positive regulation of nucleobase-containing compound metabolic process;actin filament-based process;regulation of peptidase activity;regulation of endopeptidase activity;peptidyl-cysteine S-nitrosylation;neutrophil aggregation;metal ion homeostasis;cell-cell signaling;response to chemical;neurogenesis;zinc ion homeostasis;organelle organization;primary metabolic process;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;regulation of peptide transport;positive regulation of apoptotic signaling pathway;regulation of metabolic process;regulation of apoptotic signaling pathway;positive regulation of response to stimulus;regulation of response to stimulus;cell chemotaxis;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;regulation of signal transduction;positive regulation of signal transduction;positive regulation of biological process;amide biosynthetic process;regulation of cellular protein metabolic process;single organism signaling;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;immune system process;movement of cell or subcellular component;nucleic acid-templated transcription;integrin biosynthetic process;regulation of hemostasis;cell migration;positive regulation of hemostasis;transport;defense response;programmed cell death;response to stress;coagulation;inflammatory response;immune response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of coagulation;peptidyl-cysteine modification;secretion;cellular nitrogen compound biosynthetic process;protein maturation;regulation of response to stress;regulation of transcription, DNA-templated;transcription, DNA-templated;RNA biosynthetic process;cell differentiation;peptide transport;nucleobase-containing compound metabolic process;positive regulation of cellular protein metabolic process;granulocyte migration;proteolysis;developmental process;multicellular organismal process;cellular process;sequestering of zinc ion;regulation of nucleic acid-templated transcription;protein processing;regulation of localization;regulation of RNA metabolic process;positive regulation of RNA metabolic process;cytokine production;chemokine production;positive regulation of cysteine-type endopeptidase activity;zymogen activation;nitrogen compound transport;organic substance metabolic process;organic substance transport;activation of cysteine-type endopeptidase activity involved in apoptotic process;autophagy;apoptotic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;localization;single-organism localization;single-organism organelle organization;regulation of primary metabolic process;membrane organization;transition metal ion homeostasis;taxis;posttranscriptional regulation of gene expression;response to bacterium;peptide biosynthetic process;response to wounding;peptidyl-amino acid modification;regulation of cysteine-type endopeptidase activity involved in apoptotic process;positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;cellular homeostasis;regulation of macromolecule metabolic process;regulation of proteolysis;cell motility;chemical homeostasis;regulation of blood coagulation;aromatic compound biosynthetic process;positive regulation of blood coagulation;glial cell development;defense response to bacterium;organic substance biosynthetic process;cell growth;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;gliogenesis;wound healing;protein modification process;biological_process;regulation of plasma membrane organization;metabolic process;astrocyte development;positive regulation of cell growth;ion homeostasis;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;central nervous system development;divalent inorganic cation homeostasis;amide transport;leukocyte aggregation;cellular divalent inorganic cation homeostasis;biological adhesion;positive regulation of transcription, DNA-templated;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;positive regulation of NF-kappaB transcription factor activity;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of sequence-specific DNA binding transcription factor activity;cellular amide metabolic process;macromolecule metabolic process;positive regulation of gene expression;response to fungus;positive regulation of proteolysis;myeloid leukocyte migration;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of wound healing;positive regulation of cell death;regulation of cell death;growth;regulation of growth;gene expression;regulation of gene expression;cellular aromatic compound metabolic process;leukocyte cell-cell adhesion;cell adhesion;cell communication;cytoskeleton organization;cellular macromolecule metabolic process;nervous system development; 5;5;4;4;5;7;3;4;6;4;6;4;4;5;4;3;3;4;3;4;5;2;6;9;4;5;3;4;6;5;4;5;5;5;4;4;4;6;9;4;8;6;4;4;6;3;6;5;5;6;4;3;4;4;8;6;6;5;5;5;4;6;3;4;3;8;7;2;3;6;6;3;4;5;4;5;5;4;5;4;4;3;6;3;2;3;4;3;5;9;5;4;4;7;3;3;4;3;3;5;2;5;4;5;4;2;3;5;5;6;5;4;6;5;6;3;4;4;4;8;6;6;5;6;5;4;6;7;8;7;8;4;3;6;9;4;3;6;6;5;3;5;5;3;5;3;3;5;5;2;4;4;2;6;5;3;4;5;2;4;7;6;4;4;4;4;4;5;3;4;5;3;5;5;5;4;8;5;5;5;4;6;6;6;5;6;4;5;5;5;2;2;2;5;7;6;3;5;5;4;5;9;7;5;3;5;7;3;6;3;5;4;4;2;3;4;4;4;9;3;6;4;6;4;7;7;7;4;4;6;3;5;5;5;5;5;5;4;3;3;2;3;3;7;5;5;1;5;2;6;4;6;3;4;4;2;5;3;4;4;5;8;5;6;8;2;6;7;7;5;6;5;4;5;4;5;4;6;4;7;5;5;4;4;5;5;4;4;2;3;5;5;4;5;3;4;5;4;5; GO:0044424;GO:0044421;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0016020;GO:0043230;GO:0043232;GO:0005829;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0043226;GO:0005856;GO:0044444;GO:0005737;GO:0005634;GO:0031982;GO:0043231;GO:0005623;GO:0005886;GO:1903561;GO:0005575;GO:0005576; intracellular part;extracellular region part;cell part;cell periphery;extracellular space;extracellular exosome;membrane;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;organelle;cytoskeleton;cytoplasmic part;cytoplasm;nucleus;vesicle;intracellular membrane-bounded organelle;cell;plasma membrane;extracellular vesicle;cellular_component;extracellular region; 3;2;2;3;3;4;2;3;4;5;3;3;3;3;2;5;4;4;5;4;4;2;3;3;1;2; GO:0050786;GO:0005488;GO:0005509;GO:0005504;GO:0008289;GO:0033293;GO:0050542;GO:0050543;GO:0050544;GO:0016209;GO:0046914;GO:0032403;GO:0005515;GO:0005102;GO:0046872;GO:1901567;GO:0003674;GO:0008092;GO:0031406;GO:0043167;GO:0035325;GO:0036094;GO:0008270;GO:0035662;GO:0044877;GO:0043168;GO:0043169;GO:0008017;GO:0036041;GO:0043177;GO:0004871;GO:0015631; RAGE receptor binding;binding;calcium ion binding;fatty acid binding;lipid binding;monocarboxylic acid binding;icosanoid binding;icosatetraenoic acid binding;arachidonic acid binding;antioxidant activity;transition metal ion binding;protein complex binding;protein binding;receptor binding;metal ion binding;fatty acid derivative binding;molecular_function;cytoskeletal protein binding;carboxylic acid binding;ion binding;Toll-like receptor binding;small molecule binding;zinc ion binding;Toll-like receptor 4 binding;macromolecular complex binding;anion binding;cation binding;microtubule binding;long-chain fatty acid binding;organic acid binding;signal transducer activity;tubulin binding; 5;2;6;4;3;6;4;6;5;2;6;4;3;4;5;3;1;4;5;3;5;3;7;6;3;4;4;5;5;4;2;5; K21128 IPR018247;IPR013787;IPR028475;IPR011992;IPR001751;IPR002048; EF-Hand 1, calcium-binding site;S100/CaBP-9k-type, calcium binding, subdomain;Protein S100-A9;EF-hand domain pair;S100/Calbindin-D9k, conserved site;EF-hand domain; cytosol P68871 Hemoglobin subunit beta OS=Homo sapiens OX=9606 GN=HBB PE=1 SV=2 - [HBB_HUMAN] 0.856 1.035 1.073 1.114 1.034 1.048 0.82705314 8.55E-25 1.077369439 6.78E-10 1.036714976 0.143275453 1.013539652 0.000354866 GO:0005833;GO:0005737;GO:0043234;GO:0032991;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044445;GO:0044424; hemoglobin complex;cytoplasm;protein complex;macromolecular complex;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;cytosolic part;intracellular part; 4;4;3;2;5;2;2;3;1;4;5;3; GO:0005344;GO:0003674;GO:0005488;GO:1901363;GO:0043169;GO:0046914;GO:0043167;GO:0005506;GO:0046872;GO:0020037;GO:0005215;GO:0022892;GO:0019825;GO:0046906;GO:0097159; oxygen transporter activity;molecular_function;binding;heterocyclic compound binding;cation binding;transition metal ion binding;ion binding;iron ion binding;metal ion binding;heme binding;transporter activity;substrate-specific transporter activity;oxygen binding;tetrapyrrole binding;organic cyclic compound binding; 4;1;2;3;4;6;3;7;5;5;2;3;3;4;3; K13823 map05143;map05144; African trypanosomiasis;Malaria; IPR002337;IPR000971;IPR009050; Haemoglobin, beta-type;Globin;Globin-like; cytosol Hs4504349 301.0 C [C] Energy production and conversion; P61236 Protein yippee-like 3 OS=Homo sapiens OX=9606 GN=YPEL3 PE=2 SV=1 - [YPEL3_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0090342;GO:0090343;GO:0048584;GO:0048583;GO:0050789;GO:0044699;GO:0051716;GO:0048869;GO:0065007;GO:0048518;GO:0032502;GO:0050793;GO:0009987;GO:0050794;GO:0044767;GO:0006950;GO:0044763;GO:0007568;GO:0007569;GO:0051094;GO:0050896;GO:0090398;GO:0033554;GO:0080135;GO:0008150;GO:2000774;GO:2000772;GO:0080134;GO:0048522; regulation of cell aging;positive regulation of cell aging;positive regulation of response to stimulus;regulation of response to stimulus;regulation of biological process;single-organism process;cellular response to stimulus;cellular developmental process;biological regulation;positive regulation of biological process;developmental process;regulation of developmental process;cellular process;regulation of cellular process;single-organism developmental process;response to stress;single-organism cellular process;aging;cell aging;positive regulation of developmental process;response to stimulus;cellular senescence;cellular response to stress;regulation of cellular response to stress;biological_process;positive regulation of cellular senescence;regulation of cellular senescence;regulation of response to stress;positive regulation of cellular process; 4;4;3;3;2;2;3;4;2;2;2;3;2;3;3;3;3;4;5;3;2;5;4;4;1;4;5;4;3; GO:0031974;GO:0043226;GO:0043229;GO:0043228;GO:0043227;GO:0031981;GO:0005730;GO:0005634;GO:0043233;GO:0005575;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;organelle;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;nuclear lumen;nucleolus;nucleus;organelle lumen;cellular_component;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;2;3;3;3;5;5;5;3;1;4;4;2;2;3;3;4;4;3;2; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0046872; molecular_function;binding;cation binding;ion binding;metal ion binding; 1;2;4;3;5; IPR004910;IPR034751; Yippee/Mis18/Cereblon;Yippee domain; extracellular Hs13899334 253.0 R [R] General function prediction only; Q86YP4 Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1 - [P66A_HUMAN] 0.93 0.82 1.325 0.902 0.835 2.019 1.134146341 nan 1.080239521 nan 1.615853659 nan 2.417964072 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0006306;GO:0006305;GO:0006304;GO:0010605;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0032259;GO:0018130;GO:0009889;GO:0050794;GO:0043412;GO:0044728;GO:0008150;GO:0008152;GO:0016070;GO:0044271;GO:0006355;GO:0006357;GO:0006351;GO:0043414;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0000122;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051253;GO:0051252;GO:0010629;GO:0043170;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0006259;GO:0034654;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;DNA methylation;DNA alkylation;DNA modification;negative regulation of macromolecule metabolic process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;methylation;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;DNA methylation or demethylation;biological_process;metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;macromolecule methylation;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;macromolecule metabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;DNA metabolic process;nucleobase-containing compound biosynthetic process;negative regulation of cellular process; 4;3;5;4;5;7;6;4;2;4;6;4;5;3;4;3;7;4;4;2;7;3;5;4;3;5;7;1;2;5;5;6;7;6;4;5;6;4;4;5;4;7;2;4;7;7;6;5;5;5;4;5;5;4;4;5;6;6;2;3;5;5;5;5;5;6;3;5;4;4;3;3;5;5;3; GO:0031974;GO:0031981;GO:1902494;GO:0090545;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0016607;GO:0016604;GO:0005654;GO:0090568;GO:0044446;GO:0070603;GO:0005634;GO:0044451;GO:0000118;GO:0044464;GO:0005623;GO:0017053;GO:0032991;GO:0016581;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;catalytic complex;CHD-type complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nuclear speck;nuclear body;nucleoplasm;nuclear transcriptional repressor complex;intracellular organelle part;SWI/SNF superfamily-type complex;nucleus;nucleoplasm part;histone deacetylase complex;cell part;cell;transcriptional repressor complex;macromolecular complex;NuRD complex;cellular_component;intracellular organelle lumen; 2;5;4;5;3;4;3;4;3;2;3;3;3;2;7;6;5;5;3;4;5;5;5;2;2;4;2;6;1;4; GO:0043169;GO:0001071;GO:1901363;GO:0060090;GO:0008270;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043565;GO:0030674;GO:0097159;GO:0046914;GO:0043167;GO:0046872;GO:0005515;GO:0003700; cation binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;binding, bridging;zinc ion binding;molecular_function;binding;nucleic acid binding;DNA binding;sequence-specific DNA binding;protein binding, bridging;organic cyclic compound binding;transition metal ion binding;ion binding;metal ion binding;protein binding;transcription factor activity, sequence-specific DNA binding; 4;2;3;3;7;1;2;4;5;6;4;3;6;3;5;3;3; K23194 IPR000679;IPR013088;IPR032346; Zinc finger, GATA-type;Zinc finger, NHR/GATA-type;Transcriptional repressor p66, coiled-coil MBD2-interaction domain; nucleus Hs19923502 983.0 S [S] Function unknown; P22792 Carboxypeptidase N subunit 2 OS=Homo sapiens OX=9606 GN=CPN2 PE=1 SV=3 - [CPN2_HUMAN] 0.986 1.011 0.988 1.01 1.049 1 0.975272008 0.06428046 0.962821735 0.792843065 0.977250247 0.149268938 0.953288847 0.08269905 GO:0065007;GO:0050821;GO:0031647;GO:0050790;GO:0065008;GO:0008150;GO:0065009; biological regulation;protein stabilization;regulation of protein stability;regulation of catalytic activity;regulation of biological quality;biological_process;regulation of molecular function; 2;5;4;4;3;1;3; GO:0043230;GO:0070062;GO:0005615;GO:0072562;GO:0044421;GO:0005575;GO:0005576;GO:1903561;GO:0043227;GO:0043226;GO:0031982; extracellular organelle;extracellular exosome;extracellular space;blood microparticle;extracellular region part;cellular_component;extracellular region;extracellular vesicle;membrane-bounded organelle;organelle;vesicle; 3;4;3;3;2;1;2;3;3;2;4; GO:0098772;GO:0030234;GO:0003674; molecular function regulator;enzyme regulator activity;molecular_function; 2;3;1; K13023 IPR003591;IPR032675;IPR000483;IPR000372;IPR001611; Leucine-rich repeat, typical subtype;Leucine-rich repeat domain, L domain-like;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat N-terminal domain;Leucine-rich repeat; extracellular Hs18677767 195.0 R [R] General function prediction only; Q9BT92 Trichoplein keratin filament-binding protein OS=Homo sapiens OX=9606 GN=TCHP PE=1 SV=1 - [TCHP_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0060491;GO:0031345;GO:0031344;GO:0071840;GO:0048869;GO:0048519;GO:0051128;GO:0010639;GO:0044782;GO:0022604;GO:0022607;GO:0022603;GO:0016049;GO:0000902;GO:0016043;GO:0065007;GO:1902018;GO:1902017;GO:0048646;GO:0042384;GO:0060271;GO:0050793;GO:0050794;GO:0012501;GO:0008150;GO:0030308;GO:0033043;GO:0051129;GO:0010927;GO:0009653;GO:0044699;GO:0032502;GO:0009987;GO:0001558;GO:0032990;GO:0051093;GO:0045926;GO:0030030;GO:0030031;GO:0008219;GO:0040007;GO:0040008;GO:0050789;GO:1902115;GO:1902116;GO:0006915;GO:0044767;GO:0044763;GO:0070925;GO:0006996;GO:0048858;GO:0048856;GO:0044087;GO:1902589;GO:0044085;GO:0032989;GO:0048523; regulation of cell projection assembly;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;cellular developmental process;negative regulation of biological process;regulation of cellular component organization;negative regulation of organelle organization;cilium organization;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;cell growth;cell morphogenesis;cellular component organization;biological regulation;negative regulation of cilium assembly;regulation of cilium assembly;anatomical structure formation involved in morphogenesis;cilium assembly;cilium morphogenesis;regulation of developmental process;regulation of cellular process;programmed cell death;biological_process;negative regulation of cell growth;regulation of organelle organization;negative regulation of cellular component organization;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;single-organism process;developmental process;cellular process;regulation of cell growth;cell part morphogenesis;negative regulation of developmental process;negative regulation of growth;cell projection organization;cell projection assembly;cell death;growth;regulation of growth;regulation of biological process;regulation of organelle assembly;negative regulation of organelle assembly;apoptotic process;single-organism developmental process;single-organism cellular process;organelle assembly;organelle organization;cell projection morphogenesis;anatomical structure development;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;cellular component morphogenesis;negative regulation of cellular process; 4;5;5;2;4;2;4;5;5;5;4;4;3;5;3;2;4;5;3;5;6;3;3;5;1;4;5;4;4;3;2;2;2;4;5;3;3;4;5;4;2;3;2;4;5;6;3;3;5;4;5;3;3;4;3;4;3; GO:0099512;GO:0099513;GO:0005815;GO:0042995;GO:0016020;GO:0043234;GO:0043231;GO:0043232;GO:0030054;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0043227;GO:0043226;GO:0005856;GO:0045111;GO:0030057;GO:0044430;GO:0070161;GO:0005938;GO:0044446;GO:0044444;GO:0044441;GO:0099568;GO:0044448;GO:0005737;GO:0045177;GO:0045179;GO:0005739;GO:0099738;GO:0097539;GO:0005911;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0045095;GO:0071944;GO:0005813;GO:0015630;GO:0005882;GO:0005886;GO:0032991;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;microtubule organizing center;cell projection;membrane;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell junction;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;membrane-bounded organelle;organelle;cytoskeleton;intermediate filament cytoskeleton;desmosome;cytoskeletal part;anchoring junction;cell cortex;intracellular organelle part;cytoplasmic part;ciliary part;cytoplasmic region;cell cortex part;cytoplasm;apical part of cell;apical cortex;mitochondrion;cell cortex region;ciliary transition fiber;cell-cell junction;cell projection part;cell part;cell;intracellular;keratin filament;cell periphery;centrosome;microtubule cytoskeleton;intermediate filament;plasma membrane;macromolecular complex;cellular_component; 2;3;5;3;2;3;4;4;2;3;2;3;3;3;3;2;5;6;4;4;3;4;3;4;3;5;5;4;3;4;5;5;4;3;3;2;2;3;5;3;5;6;4;3;2;1; K16811 IPR026773; Trichoplein keratin filament-binding protein; nucleus Q96IU4 Protein ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1 - [ABHEB_HUMAN] 0.88 0.907 1.369 0.802 1.023 1.326 0.970231533 0.790343387 0.783968719 0.120385691 1.509371555 0.024344565 1.296187683 0.052882942 GO:0080090;GO:0019222;GO:0044281;GO:1901362;GO:1901360;GO:0051716;GO:0010604;GO:0055086;GO:0048518;GO:0060255;GO:2001141;GO:0043436;GO:1901564;GO:0046128;GO:0046483;GO:0009410;GO:0006163;GO:0019438;GO:0009893;GO:0009891;GO:0006805;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0019637;GO:0018130;GO:0009889;GO:0044710;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0009150;GO:0016070;GO:0044271;GO:0050896;GO:0033865;GO:0006355;GO:0071466;GO:0006357;GO:0006351;GO:0044763;GO:0006753;GO:0009116;GO:0032774;GO:0044249;GO:0034641;GO:0070887;GO:0009259;GO:0044699;GO:0006139;GO:0010557;GO:0042278;GO:0033875;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0034645;GO:0045893;GO:0034035;GO:0050427;GO:0034032;GO:0006082;GO:1901135;GO:0051252;GO:0051254;GO:1902680;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0019693;GO:0072521;GO:0010628;GO:1901657;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0009117;GO:0051171;GO:0051173;GO:0042221;GO:0009119;GO:0044238;GO:0044237;GO:0006796;GO:0006790;GO:0006793;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;small molecule metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;positive regulation of macromolecule metabolic process;nucleobase-containing small molecule metabolic process;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;oxoacid metabolic process;organonitrogen compound metabolic process;purine ribonucleoside metabolic process;heterocycle metabolic process;response to xenobiotic stimulus;purine nucleotide metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;xenobiotic metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;organophosphate metabolic process;heterocycle biosynthetic process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;purine ribonucleotide metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;nucleoside bisphosphate metabolic process;regulation of transcription, DNA-templated;cellular response to xenobiotic stimulus;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;single-organism cellular process;nucleoside phosphate metabolic process;nucleoside metabolic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular response to chemical stimulus;ribonucleotide metabolic process;single-organism process;nucleobase-containing compound metabolic process;positive regulation of macromolecule biosynthetic process;purine nucleoside metabolic process;ribonucleoside bisphosphate metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular macromolecule biosynthetic process;positive regulation of transcription, DNA-templated;purine ribonucleoside bisphosphate metabolic process;3'-phosphoadenosine 5'-phosphosulfate metabolic process;purine nucleoside bisphosphate metabolic process;organic acid metabolic process;carbohydrate derivative metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;ribose phosphate metabolic process;purine-containing compound metabolic process;positive regulation of gene expression;glycosyl compound metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;nucleotide metabolic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;ribonucleoside metabolic process;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;sulfur compound metabolic process;phosphorus metabolic process;positive regulation of cellular process; 4;3;4;5;4;3;4;4;2;4;6;5;4;7;4;4;6;5;3;4;4;3;4;7;4;4;2;7;4;5;4;3;3;1;2;5;7;5;5;2;6;6;5;7;6;3;5;5;6;4;4;4;6;2;4;5;6;7;7;2;4;7;5;6;7;5;6;4;4;5;5;6;7;5;5;4;4;5;5;5;5;4;6;2;3;5;5;5;5;5;3;5;6;4;4;3;6;3;3;5;4;4;3; GO:0031974;GO:0031981;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0031982;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0070062;GO:0044444;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;nuclear lumen;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;vesicle;intracellular organelle part;cytoplasm;nucleolus;nucleus;cell part;cell;intracellular;non-membrane-bounded organelle;extracellular exosome;cytoplasmic part;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;5;3;4;4;3;5;4;3;2;2;3;3;2;4;3;4;5;5;2;2;3;3;4;4;3;1;4;2; GO:0003674;GO:0016787;GO:0003824; molecular_function;hydrolase activity;catalytic activity; 1;3;2; K13706 IPR000073;IPR029058;IPR026764; Alpha/beta hydrolase fold-1;Alpha/Beta hydrolase fold;Protein ABHD14B; cytosol, nucleus Hs14249382 426.0 R [R] General function prediction only; Q99684 Zinc finger protein Gfi-1 OS=Homo sapiens OX=9606 GN=GFI1 PE=1 SV=2 - [GFI1_HUMAN] 0.648 0.871 1.922 0.776 0.755 1.025 0.743972445 nan 1.02781457 nan 2.206659013 nan 1.357615894 nan GO:0006479;GO:0006775;GO:0060556;GO:0080090;GO:0019222;GO:0070103;GO:0048584;GO:0048583;GO:0000083;GO:0031349;GO:0043933;GO:0060759;GO:0007165;GO:0051569;GO:0051568;GO:0030182;GO:0046137;GO:1901362;GO:0031347;GO:0019221;GO:0051716;GO:0044711;GO:0010605;GO:0009966;GO:0048869;GO:0071840;GO:0009617;GO:0010467;GO:0018193;GO:0043433;GO:0044419;GO:0045664;GO:0032268;GO:0010894;GO:0009967;GO:0060558;GO:0044092;GO:0048518;GO:0065007;GO:0046483;GO:1902931;GO:0016570;GO:0051055;GO:0016571;GO:1903308;GO:0060255;GO:0000082;GO:0001961;GO:0051090;GO:0010977;GO:0010975;GO:2001141;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0044843;GO:0009607;GO:0009605;GO:0019538;GO:0046165;GO:0070105;GO:0002376;GO:0018205;GO:0007154;GO:0010629;GO:0019438;GO:0044707;GO:0009892;GO:0034645;GO:0009890;GO:0018022;GO:0031056;GO:0006807;GO:0010721;GO:0032496;GO:0043170;GO:0050789;GO:0097659;GO:0045934;GO:0010956;GO:1901576;GO:0019218;GO:0002764;GO:0044260;GO:0031345;GO:0071354;GO:0019216;GO:0016043;GO:0031344;GO:0045939;GO:0002684;GO:0070741;GO:0002682;GO:1901360;GO:0071219;GO:0006366;GO:0071216;GO:0065009;GO:0032259;GO:0044281;GO:0018130;GO:0050790;GO:0034097;GO:0050767;GO:0050793;GO:0032768;GO:0032769;GO:0009889;GO:0044710;GO:0048468;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:0060760;GO:0009059;GO:0030656;GO:0002520;GO:0016070;GO:0044767;GO:0002757;GO:0044271;GO:0043207;GO:0071345;GO:0050896;GO:0002758;GO:0043412;GO:0009110;GO:0032088;GO:0002218;GO:0051961;GO:0006357;GO:0006351;GO:0044283;GO:0043414;GO:0016569;GO:0010558;GO:1901615;GO:0033044;GO:0050810;GO:0032774;GO:0033043;GO:0030154;GO:0042368;GO:0051129;GO:0051128;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0060284;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0043086;GO:0044699;GO:0006139;GO:0006629;GO:0000122;GO:0051960;GO:0051241;GO:0051246;GO:1902930;GO:0050768;GO:0030030;GO:0034968;GO:0048513;GO:0031399;GO:0002224;GO:0031060;GO:0031175;GO:0002221;GO:0032502;GO:0006996;GO:0032501;GO:0044238;GO:0070102;GO:0009987;GO:0071396;GO:1903506;GO:0034121;GO:0045596;GO:0045595;GO:0045892;GO:0048519;GO:0016032;GO:0008202;GO:0051276;GO:0051093;GO:0044770;GO:0007049;GO:0050776;GO:0001959;GO:0051253;GO:0051252;GO:0050778;GO:0051239;GO:0045833;GO:0008213;GO:0002237;GO:0030099;GO:0048731;GO:0080134;GO:1902275;GO:0071222;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:1903047;GO:0090304;GO:0044772;GO:0006766;GO:0022402;GO:0046890;GO:0007275;GO:0006066;GO:0042359;GO:0006355;GO:0006325;GO:0033993;GO:0007166;GO:2000112;GO:2000113;GO:0071704;GO:0071310;GO:0010556;GO:0045665;GO:1901617;GO:0048534;GO:0010468;GO:0006694;GO:0048666;GO:0045089;GO:0045088;GO:0044267;GO:0019219;GO:0006725;GO:0045087;GO:0042362;GO:0051341;GO:0006464;GO:1902679;GO:0009058;GO:0044764;GO:0044763;GO:0051171;GO:0051172;GO:0042221;GO:0022008;GO:1903507;GO:0016568;GO:0010957;GO:0008610;GO:1901700;GO:1901701;GO:0048699;GO:0007399;GO:0000278;GO:0048856;GO:0044237;GO:0030097;GO:1902589;GO:0051354;GO:2000026;GO:0002253;GO:0044403;GO:0048523;GO:0048522; protein methylation;fat-soluble vitamin metabolic process;regulation of vitamin D biosynthetic process;regulation of primary metabolic process;regulation of metabolic process;regulation of interleukin-6-mediated signaling pathway;positive regulation of response to stimulus;regulation of response to stimulus;regulation of transcription involved in G1/S transition of mitotic cell cycle;positive regulation of defense response;macromolecular complex subunit organization;regulation of response to cytokine stimulus;signal transduction;regulation of histone H3-K4 methylation;histone H3-K4 methylation;neuron differentiation;negative regulation of vitamin metabolic process;organic cyclic compound biosynthetic process;regulation of defense response;cytokine-mediated signaling pathway;cellular response to stimulus;single-organism biosynthetic process;negative regulation of macromolecule metabolic process;regulation of signal transduction;cellular developmental process;cellular component organization or biogenesis;response to bacterium;gene expression;peptidyl-amino acid modification;negative regulation of sequence-specific DNA binding transcription factor activity;interspecies interaction between organisms;regulation of neuron differentiation;regulation of cellular protein metabolic process;negative regulation of steroid biosynthetic process;positive regulation of signal transduction;regulation of calcidiol 1-monooxygenase activity;negative regulation of molecular function;positive regulation of biological process;biological regulation;heterocycle metabolic process;negative regulation of alcohol biosynthetic process;histone modification;negative regulation of lipid biosynthetic process;histone methylation;regulation of chromatin modification;regulation of macromolecule metabolic process;G1/S transition of mitotic cell cycle;positive regulation of cytokine-mediated signaling pathway;regulation of sequence-specific DNA binding transcription factor activity;negative regulation of neuron projection development;regulation of neuron projection development;regulation of RNA biosynthetic process;response to other organism;response to organic substance;multi-organism process;single organism signaling;cell cycle G1/S phase transition;response to biotic stimulus;response to external stimulus;protein metabolic process;alcohol biosynthetic process;positive regulation of interleukin-6-mediated signaling pathway;immune system process;peptidyl-lysine modification;cell communication;negative regulation of gene expression;aromatic compound biosynthetic process;single-multicellular organism process;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;peptidyl-lysine methylation;regulation of histone modification;nitrogen compound metabolic process;negative regulation of cell development;response to lipopolysaccharide;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;negative regulation of nucleobase-containing compound metabolic process;negative regulation of calcidiol 1-monooxygenase activity;organic substance biosynthetic process;regulation of steroid metabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;negative regulation of cell projection organization;cellular response to interleukin-6;regulation of lipid metabolic process;cellular component organization;regulation of cell projection organization;negative regulation of steroid metabolic process;positive regulation of immune system process;response to interleukin-6;regulation of immune system process;organic cyclic compound metabolic process;cellular response to molecule of bacterial origin;transcription from RNA polymerase II promoter;cellular response to biotic stimulus;regulation of molecular function;methylation;small molecule metabolic process;heterocycle biosynthetic process;regulation of catalytic activity;response to cytokine;regulation of neurogenesis;regulation of developmental process;regulation of monooxygenase activity;negative regulation of monooxygenase activity;regulation of biosynthetic process;single-organism metabolic process;cell development;regulation of cellular process;defense response;response to stress;protein modification process;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;positive regulation of response to cytokine stimulus;macromolecule biosynthetic process;regulation of vitamin metabolic process;immune system development;RNA metabolic process;single-organism developmental process;immune response-activating signal transduction;cellular nitrogen compound biosynthetic process;response to external biotic stimulus;cellular response to cytokine stimulus;response to stimulus;innate immune response-activating signal transduction;macromolecule modification;vitamin biosynthetic process;negative regulation of NF-kappaB transcription factor activity;activation of innate immune response;negative regulation of nervous system development;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;small molecule biosynthetic process;macromolecule methylation;covalent chromatin modification;negative regulation of macromolecule biosynthetic process;organic hydroxy compound metabolic process;regulation of chromosome organization;regulation of steroid biosynthetic process;RNA biosynthetic process;regulation of organelle organization;cell differentiation;vitamin D biosynthetic process;negative regulation of cellular component organization;regulation of cellular component organization;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of cell development;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of catalytic activity;single-organism process;nucleobase-containing compound metabolic process;lipid metabolic process;negative regulation of transcription from RNA polymerase II promoter;regulation of nervous system development;negative regulation of multicellular organismal process;regulation of protein metabolic process;regulation of alcohol biosynthetic process;negative regulation of neurogenesis;cell projection organization;histone lysine methylation;animal organ development;regulation of protein modification process;toll-like receptor signaling pathway;regulation of histone methylation;neuron projection development;pattern recognition receptor signaling pathway;developmental process;organelle organization;multicellular organismal process;primary metabolic process;interleukin-6-mediated signaling pathway;cellular process;cellular response to lipid;regulation of nucleic acid-templated transcription;regulation of toll-like receptor signaling pathway;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;negative regulation of biological process;viral process;steroid metabolic process;chromosome organization;negative regulation of developmental process;cell cycle phase transition;cell cycle;regulation of immune response;regulation of cytokine-mediated signaling pathway;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of immune response;regulation of multicellular organismal process;negative regulation of lipid metabolic process;protein alkylation;response to molecule of bacterial origin;myeloid cell differentiation;system development;regulation of response to stress;regulation of chromatin organization;cellular response to lipopolysaccharide;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;mitotic cell cycle phase transition;vitamin metabolic process;cell cycle process;regulation of lipid biosynthetic process;multicellular organism development;alcohol metabolic process;vitamin D metabolic process;regulation of transcription, DNA-templated;chromatin organization;response to lipid;cell surface receptor signaling pathway;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;regulation of macromolecule biosynthetic process;negative regulation of neuron differentiation;organic hydroxy compound biosynthetic process;hematopoietic or lymphoid organ development;regulation of gene expression;steroid biosynthetic process;neuron development;positive regulation of innate immune response;regulation of innate immune response;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;innate immune response;fat-soluble vitamin biosynthetic process;regulation of oxidoreductase activity;cellular protein modification process;negative regulation of RNA biosynthetic process;biosynthetic process;multi-organism cellular process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;response to chemical;neurogenesis;negative regulation of nucleic acid-templated transcription;chromatin modification;negative regulation of vitamin D biosynthetic process;lipid biosynthetic process;response to oxygen-containing compound;cellular response to oxygen-containing compound;generation of neurons;nervous system development;mitotic cell cycle;anatomical structure development;cellular metabolic process;hemopoiesis;single-organism organelle organization;negative regulation of oxidoreductase activity;regulation of multicellular organismal development;activation of immune response;symbiosis, encompassing mutualism through parasitism;negative regulation of cellular process;positive regulation of cellular process; 5;6;5;4;3;6;3;3;6;4;4;4;4;7;7;6;4;5;5;6;3;4;4;4;4;2;4;5;7;5;3;7;5;6;4;6;4;2;2;4;5;4;5;5;7;4;7;5;4;6;6;6;3;4;2;3;6;3;3;4;6;6;2;8;4;5;5;3;3;5;4;6;5;3;5;5;4;2;7;5;6;4;6;5;4;5;7;5;3;5;5;3;6;3;4;5;7;4;3;3;4;5;4;5;6;3;5;5;4;3;4;3;4;3;5;1;2;3;5;4;5;4;3;5;3;4;5;4;6;2;5;5;4;6;4;4;7;6;5;4;7;5;4;6;6;6;5;5;6;4;4;3;4;4;2;5;4;3;4;4;5;2;4;4;7;5;3;5;5;5;4;6;4;6;7;6;5;6;2;4;2;3;7;2;6;7;5;4;4;6;2;4;5;5;3;5;4;4;5;5;5;4;3;4;7;5;6;4;4;6;6;5;5;4;4;5;5;6;5;4;5;4;5;6;6;5;5;5;6;6;3;5;5;6;5;4;5;6;5;5;5;5;5;4;4;5;4;6;6;3;3;3;4;4;3;6;7;6;5;5;4;5;7;5;5;3;3;5;4;4;4;3;4;3;3; GO:0031974;GO:0031981;GO:0043234;GO:0016363;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0016604;GO:0005654;GO:0044446;GO:0034399;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0017053;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;protein complex;nuclear matrix;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nuclear body;nucleoplasm;intracellular organelle part;nuclear periphery;nucleus;nucleoplasm part;cell part;cell;intracellular;organelle;transcriptional repressor complex;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;3;5;4;3;4;3;2;3;3;6;5;3;5;5;5;2;2;3;2;4;2;1;4; GO:1901363;GO:0001078;GO:0044212;GO:0001067;GO:0001227;GO:0043169;GO:0008270;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000982;GO:0000981;GO:0097159;GO:0000975;GO:0043167;GO:0001071;GO:0046914;GO:0046872;GO:0003700; heterocyclic compound binding;transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;transcription regulatory region DNA binding;regulatory region nucleic acid binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;cation binding;zinc ion binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;regulatory region DNA binding;ion binding;nucleic acid binding transcription factor activity;transition metal ion binding;metal ion binding;transcription factor activity, sequence-specific DNA binding; 3;6;7;5;5;4;7;1;2;4;5;5;4;3;6;3;2;6;5;3; K09223 IPR013087;IPR029840; Zinc finger C2H2-type;Zinc finger protein Gfi-1/1b; nucleus Hs4885267 830.0 R [R] General function prediction only; Q6ZT07 TBC1 domain family member 9 OS=Homo sapiens OX=9606 GN=TBC1D9 PE=2 SV=2 - [TBCD9_HUMAN] 0.922 0.844 1.474 0.784 0.928 1.527 1.092417062 0.332527954 0.844827586 0.329755709 1.746445498 0.004564951 1.645474138 0.027280589 GO:0005488;GO:0043169;GO:0046872;GO:0030234;GO:0005096;GO:0043167;GO:0030695;GO:0003674;GO:0008047;GO:0098772;GO:0060589;GO:0005509; binding;cation binding;metal ion binding;enzyme regulator activity;GTPase activator activity;ion binding;GTPase regulator activity;molecular_function;enzyme activator activity;molecular function regulator;nucleoside-triphosphatase regulator activity;calcium ion binding; 2;4;5;3;5;3;5;1;4;2;4;6; K19951 IPR000195;IPR002048;IPR011992;IPR004182;IPR011993; Rab-GTPase-TBC domain;EF-hand domain;EF-hand domain pair;GRAM domain;PH domain-like; endoplasmic reticulum Hs22042713 2632.0 R [R] General function prediction only; O60240 Perilipin-1 OS=Homo sapiens OX=9606 GN=PLIN1 PE=1 SV=2 - [PLIN1_HUMAN] 0.761 0.9 1.562 0.903 0.929 1.059 0.845555556 nan 0.972012917 nan 1.735555556 nan 1.139935414 nan GO:0044237;GO:0006639;GO:0006638;GO:0044248;GO:0044242;GO:0044255;GO:0044699;GO:0044712;GO:0044710;GO:0016042;GO:0071704;GO:1901575;GO:0046464;GO:0046503;GO:0046461;GO:0006629;GO:0006641;GO:0009987;GO:0008150;GO:0008152;GO:0046486;GO:0009056;GO:0044238;GO:0019433;GO:0044763;GO:0044281; cellular metabolic process;acylglycerol metabolic process;neutral lipid metabolic process;cellular catabolic process;cellular lipid catabolic process;cellular lipid metabolic process;single-organism process;single-organism catabolic process;single-organism metabolic process;lipid catabolic process;organic substance metabolic process;organic substance catabolic process;acylglycerol catabolic process;glycerolipid catabolic process;neutral lipid catabolic process;lipid metabolic process;triglyceride metabolic process;cellular process;biological_process;metabolic process;glycerolipid metabolic process;catabolic process;primary metabolic process;triglyceride catabolic process;single-organism cellular process;small molecule metabolic process; 3;6;5;4;5;4;2;4;3;5;3;4;7;6;6;4;7;2;1;2;5;3;3;8;3;4; GO:0005783;GO:0043229;GO:0043228;GO:0043226;GO:0043227;GO:0005811;GO:0044444;GO:0005737;GO:0012505;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; endoplasmic reticulum;intracellular organelle;non-membrane-bounded organelle;organelle;membrane-bounded organelle;lipid particle;cytoplasmic part;cytoplasm;endomembrane system;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 4;3;3;2;3;5;4;4;3;4;4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0008289; molecular_function;binding;lipid binding; 1;2;3; K08768 map03320;map04923; PPAR signaling pathway;Regulation of lipolysis in adipocytes; IPR004279; Perilipin; nucleus Hs4505885 1048.0 UI [U] Intracellular trafficking, secretion, and vesicular transport;[I] Lipid transport and metabolism; Q96IU2 Zinc finger BED domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBED3 PE=1 SV=1 - [ZBED3_HUMAN] 1.041 1.216 0.781 1.182 1.211 0.399 0.856085526 0.300547679 0.976052849 0.468582746 0.642269737 0.075742222 0.329479769 0.003784483 GO:0033157;GO:0008104;GO:0032388;GO:0080090;GO:0019222;GO:0051049;GO:0032386;GO:0048584;GO:0048583;GO:0030111;GO:0007165;GO:0007166;GO:0070585;GO:0019220;GO:1901362;GO:0071840;GO:0007005;GO:0051716;GO:0010605;GO:0010604;GO:0070727;GO:0009966;GO:0009967;GO:0048518;GO:0048519;GO:1903749;GO:0051050;GO:0060255;GO:0006605;GO:0045184;GO:1903955;GO:0032268;GO:0072655;GO:0006839;GO:0046483;GO:0042325;GO:1903827;GO:0042326;GO:0019538;GO:0016055;GO:0010638;GO:0019438;GO:0060828;GO:0009892;GO:0034645;GO:0009891;GO:0090263;GO:1903651;GO:0050821;GO:0030177;GO:0006807;GO:0051222;GO:0051223;GO:0050789;GO:0097659;GO:1901576;GO:1904951;GO:0044260;GO:0006886;GO:0045936;GO:0016043;GO:0065007;GO:1903829;GO:0006366;GO:0065008;GO:0018130;GO:0051130;GO:0070201;GO:1903649;GO:0006626;GO:0006810;GO:0009889;GO:0050794;GO:0060070;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0051234;GO:0016070;GO:0044271;GO:0046907;GO:0050896;GO:0031647;GO:0009058;GO:0006355;GO:0006357;GO:0006351;GO:0010563;GO:0032774;GO:0033043;GO:0016310;GO:0051173;GO:0051128;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:1903533;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0032880;GO:0006139;GO:0051248;GO:0031328;GO:0051246;GO:0031399;GO:0009893;GO:1903508;GO:0043170;GO:0044238;GO:0072594;GO:0009987;GO:0006725;GO:1903506;GO:1903747;GO:0045893;GO:0032879;GO:0016482;GO:0032269;GO:0033036;GO:0051252;GO:0051254;GO:1902680;GO:0010628;GO:0045944;GO:0033365;GO:0031400;GO:0060341;GO:0044700;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0010821;GO:0010822;GO:1901360;GO:2000112;GO:0010557;GO:0071704;GO:0010467;GO:0010556;GO:0071702;GO:0010468;GO:0006468;GO:0045935;GO:0044267;GO:0019219;GO:0034613;GO:0090316;GO:0006464;GO:0051174;GO:0044765;GO:0009059;GO:0044763;GO:0051171;GO:0051649;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:2001141;GO:0001932;GO:0044237;GO:0006796;GO:1903214;GO:0006793;GO:0015031;GO:1902582;GO:0001933;GO:1902580;GO:0048523;GO:0048522; regulation of intracellular protein transport;protein localization;positive regulation of intracellular transport;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;regulation of intracellular transport;positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;protein localization to mitochondrion;regulation of phosphate metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;mitochondrion organization;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;regulation of signal transduction;positive regulation of signal transduction;positive regulation of biological process;negative regulation of biological process;positive regulation of establishment of protein localization to mitochondrion;positive regulation of transport;regulation of macromolecule metabolic process;protein targeting;establishment of protein localization;positive regulation of protein targeting to mitochondrion;regulation of cellular protein metabolic process;establishment of protein localization to mitochondrion;mitochondrial transport;heterocycle metabolic process;regulation of phosphorylation;regulation of cellular protein localization;negative regulation of phosphorylation;protein metabolic process;Wnt signaling pathway;positive regulation of organelle organization;aromatic compound biosynthetic process;regulation of canonical Wnt signaling pathway;negative regulation of metabolic process;cellular macromolecule biosynthetic process;positive regulation of biosynthetic process;positive regulation of canonical Wnt signaling pathway;positive regulation of cytoplasmic transport;protein stabilization;positive regulation of Wnt signaling pathway;nitrogen compound metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;positive regulation of establishment of protein localization;cellular macromolecule metabolic process;intracellular protein transport;negative regulation of phosphate metabolic process;cellular component organization;biological regulation;positive regulation of cellular protein localization;transcription from RNA polymerase II promoter;regulation of biological quality;heterocycle biosynthetic process;positive regulation of cellular component organization;regulation of establishment of protein localization;regulation of cytoplasmic transport;protein targeting to mitochondrion;transport;regulation of biosynthetic process;regulation of cellular process;canonical Wnt signaling pathway;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;establishment of localization;RNA metabolic process;cellular nitrogen compound biosynthetic process;intracellular transport;response to stimulus;regulation of protein stability;biosynthetic process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;negative regulation of phosphorus metabolic process;RNA biosynthetic process;regulation of organelle organization;phosphorylation;positive regulation of nitrogen compound metabolic process;regulation of cellular component organization;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;regulation of protein targeting;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of protein localization;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;positive regulation of cellular biosynthetic process;regulation of protein metabolic process;regulation of protein modification process;positive regulation of metabolic process;positive regulation of nucleic acid-templated transcription;macromolecule metabolic process;primary metabolic process;establishment of protein localization to organelle;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of establishment of protein localization to mitochondrion;positive regulation of transcription, DNA-templated;regulation of localization;cytosolic transport;negative regulation of cellular protein metabolic process;macromolecule localization;regulation of RNA metabolic process;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;protein localization to organelle;negative regulation of protein modification process;regulation of cellular localization;single organism signaling;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of mitochondrion organization;positive regulation of mitochondrion organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;organic substance transport;regulation of gene expression;protein phosphorylation;positive regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein localization;positive regulation of intracellular protein transport;cellular protein modification process;regulation of phosphorus metabolic process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;establishment of localization in cell;cell communication;localization;single-organism localization;cellular localization;organelle organization;regulation of RNA biosynthetic process;regulation of protein phosphorylation;cellular metabolic process;phosphate-containing compound metabolic process;regulation of protein targeting to mitochondrion;phosphorus metabolic process;protein transport;single-organism intracellular transport;negative regulation of protein phosphorylation;single-organism cellular localization;negative regulation of cellular process;positive regulation of cellular process; 6;4;4;4;3;4;5;3;3;5;4;5;7;6;5;2;5;3;4;4;4;4;4;2;2;4;3;4;6;4;5;5;6;6;4;7;5;7;4;6;5;5;6;3;5;4;6;5;5;5;3;4;5;2;7;4;3;4;6;6;3;2;3;7;3;5;4;5;6;5;4;4;3;7;5;5;1;2;5;3;5;5;5;2;4;3;6;7;6;5;6;5;6;4;4;3;4;4;2;7;3;4;4;2;4;4;5;5;5;6;3;7;4;3;5;2;4;7;6;6;3;6;5;3;5;5;6;5;7;6;6;4;3;5;4;4;4;5;6;6;4;6;5;3;5;5;5;5;7;5;5;5;5;4;6;5;4;5;3;4;4;4;2;3;3;4;6;7;3;5;6;4;5;5;7;4;3;3; GO:0016020;GO:0005829;GO:0044424;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575; membrane;cytosol;intracellular part;cytoplasmic part;cytoplasm;cell part;cell;intracellular;cellular_component; 2;5;3;4;4;2;2;3;1; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043169;GO:0097159;GO:0043167;GO:0046872; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;cation binding;organic cyclic compound binding;ion binding;metal ion binding; 3;1;2;4;5;4;3;3;5; IPR003656;IPR013087;IPR033546; Zinc finger, BED-type;Zinc finger C2H2-type;Zinc finger BED domain-containing protein 3; nucleus P49247 Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3 - [RPIA_HUMAN] 0.54 0.567 2.304 0.723 0.761 0.486 0.952380952 0.702327628 0.950065703 0.866307938 4.063492063 0.045171447 0.638633377 0.569029611 GO:0006739;GO:0006732;GO:0006733;GO:0009117;GO:0006098;GO:0046496;GO:0006081;GO:0044699;GO:0006139;GO:0044710;GO:0051186;GO:0072524;GO:0019682;GO:0006796;GO:0071704;GO:1901360;GO:0044281;GO:0009987;GO:0006725;GO:0019637;GO:0008150;GO:0008152;GO:0009052;GO:1901564;GO:0055086;GO:0046483;GO:0044238;GO:0005975;GO:0051156;GO:0034641;GO:0044763;GO:0006807;GO:0006793;GO:0019693;GO:0044237;GO:0006753;GO:1901135;GO:0019362; NADP metabolic process;coenzyme metabolic process;oxidoreduction coenzyme metabolic process;nucleotide metabolic process;pentose-phosphate shunt;nicotinamide nucleotide metabolic process;cellular aldehyde metabolic process;single-organism process;nucleobase-containing compound metabolic process;single-organism metabolic process;cofactor metabolic process;pyridine-containing compound metabolic process;glyceraldehyde-3-phosphate metabolic process;phosphate-containing compound metabolic process;organic substance metabolic process;organic cyclic compound metabolic process;small molecule metabolic process;cellular process;cellular aromatic compound metabolic process;organophosphate metabolic process;biological_process;metabolic process;pentose-phosphate shunt, non-oxidative branch;organonitrogen compound metabolic process;nucleobase-containing small molecule metabolic process;heterocycle metabolic process;primary metabolic process;carbohydrate metabolic process;glucose 6-phosphate metabolic process;cellular nitrogen compound metabolic process;single-organism cellular process;nitrogen compound metabolic process;phosphorus metabolic process;ribose phosphate metabolic process;cellular metabolic process;nucleoside phosphate metabolic process;carbohydrate derivative metabolic process;pyridine nucleotide metabolic process; 8;5;6;6;6;7;4;2;4;3;4;5;5;5;3;4;4;2;4;4;1;2;6;4;4;4;3;4;5;4;3;3;4;5;3;5;4;6; GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0043231;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular membrane-bounded organelle;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 3;3;2;4;4;5;2;2;3;1;4;3; GO:0005488;GO:0030246;GO:0003824;GO:0003674;GO:0016860;GO:0004751;GO:0016861;GO:0036094;GO:0016853;GO:0048029; binding;carbohydrate binding;catalytic activity;molecular_function;intramolecular oxidoreductase activity;ribose-5-phosphate isomerase activity;intramolecular oxidoreductase activity, interconverting aldoses and ketoses;small molecule binding;isomerase activity;monosaccharide binding; 2;3;2;1;4;6;5;3;3;4; K01807 map00030;map00710;map01100;map01110;map01120;map01130;map01200;map01230; Pentose phosphate pathway;Carbon fixation in photosynthetic organisms;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism;Biosynthesis of amino acids; IPR004788;IPR020672; Ribose 5-phosphate isomerase, type A;Ribose-5-phosphate isomerase, type A, subgroup; cytosol Hs21389337 489.0 G [G] Carbohydrate transport and metabolism; P01602 Immunoglobulin kappa variable 1-5 OS=Homo sapiens OX=9606 GN=IGKV1-5 PE=1 SV=2 - [KV105_HUMAN] 0.977 0.937 1.308 0.925 0.997 0.881 1.042689434 0.241053276 0.92778335 0.194423453 1.395944504 0.000429727 0.883650953 0.155834563 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0002440;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002377;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;production of molecular mediator of immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;immunoglobulin production;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P01601 Immunoglobulin kappa variable 1D-16 OS=Homo sapiens OX=9606 GN=IGKV1D-16 PE=3 SV=2 - [KVD16_HUMAN] 0.906 1.14 0.981 0.99 1.171 1.004 0.794736842 0.169618374 0.845431255 0.521201772 0.860526316 0.255600609 0.857386849 0.635054664 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q14156 Protein EFR3 homolog A OS=Homo sapiens OX=9606 GN=EFR3A PE=1 SV=2 - [EFR3A_HUMAN] 0.277 2.285 0.724 0.359 1.875 nan 0.121225383 nan 0.191466667 nan 0.316849015 nan nan nan GO:0008104;GO:0006650;GO:0016310;GO:0061024;GO:0007009;GO:0044237;GO:1990778;GO:0044802;GO:0044255;GO:0044699;GO:0044710;GO:0051234;GO:0046834;GO:0010256;GO:0006796;GO:0016043;GO:0090002;GO:0071704;GO:0071840;GO:0046854;GO:0033036;GO:0006644;GO:0034613;GO:0006629;GO:0009987;GO:0045184;GO:0019637;GO:0008150;GO:0072657;GO:0008152;GO:0046486;GO:0072659;GO:0030258;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0090150;GO:0070727;GO:0044763;GO:0006793;GO:0046488;GO:1902580; protein localization;glycerophospholipid metabolic process;phosphorylation;membrane organization;plasma membrane organization;cellular metabolic process;protein localization to cell periphery;single-organism membrane organization;cellular lipid metabolic process;single-organism process;single-organism metabolic process;establishment of localization;lipid phosphorylation;endomembrane system organization;phosphate-containing compound metabolic process;cellular component organization;establishment of protein localization to plasma membrane;organic substance metabolic process;cellular component organization or biogenesis;phosphatidylinositol phosphorylation;macromolecule localization;phospholipid metabolic process;cellular protein localization;lipid metabolic process;cellular process;establishment of protein localization;organophosphate metabolic process;biological_process;protein localization to membrane;metabolic process;glycerolipid metabolic process;protein localization to plasma membrane;lipid modification;localization;single-organism localization;cellular localization;primary metabolic process;establishment of protein localization to membrane;cellular macromolecule localization;single-organism cellular process;phosphorus metabolic process;phosphatidylinositol metabolic process;single-organism cellular localization; 4;6;6;4;5;3;6;4;4;2;3;3;6;4;5;3;6;3;2;7;3;5;5;4;2;4;4;1;5;2;5;6;5;2;3;3;3;5;4;3;4;7;4; GO:0043226;GO:0071944;GO:0005737;GO:0070062;GO:0043227;GO:1903561;GO:0016020;GO:0031982;GO:0005886;GO:0043230;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421; organelle;cell periphery;cytoplasm;extracellular exosome;membrane-bounded organelle;extracellular vesicle;membrane;vesicle;plasma membrane;extracellular organelle;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part; 2;3;4;4;3;3;2;4;3;3;5;2;2;3;1;4;2;3;2; K21842 IPR016024;IPR011989; Armadillo-type fold;Armadillo-like helical; mitochondria Hs14741682 1702.0 R [R] General function prediction only; Q4G0S7 Coiled-coil domain-containing protein 152 OS=Homo sapiens OX=9606 GN=CCDC152 PE=2 SV=3 - [CC152_HUMAN] 1.768 0.763 0.764 0.663 0.787 2.186 2.317169069 0.010493167 0.842439644 0.124643768 1.001310616 0.978594411 2.777636595 0.023853146 cytosol Q8IUG5 Unconventional myosin-XVIIIb OS=Homo sapiens OX=9606 GN=MYO18B PE=1 SV=2 - [MY18B_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0015629;GO:0030016;GO:0030017;GO:0043229;GO:0043228;GO:0044430;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0005634;GO:0016461;GO:0016459;GO:0005856;GO:0044424;GO:0043234;GO:0032991;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0043292;GO:0044422;GO:0044449; actin cytoskeleton;myofibril;sarcomere;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;nucleus;unconventional myosin complex;myosin complex;cytoskeleton;intracellular part;protein complex;macromolecular complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;contractile fiber;organelle part;contractile fiber part; 6;6;4;3;3;4;3;2;4;3;5;5;4;5;3;3;2;4;4;2;2;3;1;4;5;2;3; GO:0005488;GO:0016787;GO:0035639;GO:1901363;GO:0003674;GO:0000166;GO:1901265;GO:0001882;GO:0043167;GO:0001883;GO:0032549;GO:0017076;GO:0003774;GO:0005524;GO:0017111;GO:0036094;GO:0032555;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0003824;GO:0016817;GO:0016462;GO:0032550;GO:0032559;GO:0032553;GO:0043168; binding;hydrolase activity;purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;nucleotide binding;nucleoside phosphate binding;nucleoside binding;ion binding;purine nucleoside binding;ribonucleoside binding;purine nucleotide binding;motor activity;ATP binding;nucleoside-triphosphatase activity;small molecule binding;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;catalytic activity;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;purine ribonucleoside binding;adenyl ribonucleotide binding;ribonucleotide binding;anion binding; 2;3;5;3;1;4;4;4;3;5;5;5;8;6;7;3;5;5;6;3;3;2;4;6;6;6;4;4; K10362 IPR028561;IPR000048;IPR027417;IPR001609; Unconventional myosin-XVIIIb;IQ motif, EF-hand binding site;P-loop containing nucleoside triphosphate hydrolase;Myosin head, motor domain; nucleus Hs20373153 5227.0 Z [Z] Cytoskeleton; Q9NP61 ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1 - [ARFG3_HUMAN] 0.922 0.94 1.311 1.023 0.916 1.085 0.980851064 nan 1.116812227 nan 1.394680851 nan 1.184497817 nan GO:0008104;GO:0061024;GO:0071840;GO:0044710;GO:0070727;GO:0018196;GO:0018193;GO:0044093;GO:0033036;GO:0045184;GO:0016192;GO:0019538;GO:1901576;GO:0006888;GO:0043547;GO:0051345;GO:0006886;GO:0048193;GO:0016043;GO:0065007;GO:0043085;GO:0065009;GO:0006810;GO:0009306;GO:0050790;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0051234;GO:0051336;GO:0046903;GO:0046907;GO:0044765;GO:0043413;GO:0044249;GO:0034645;GO:0043087;GO:0044699;GO:0043687;GO:0009987;GO:1901137;GO:1901135;GO:0032940;GO:0043170;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0071704;GO:0071702;GO:0018279;GO:0044267;GO:0034613;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0005975;GO:0044260;GO:0044237;GO:0015031;GO:1902582; protein localization;membrane organization;cellular component organization or biogenesis;single-organism metabolic process;cellular macromolecule localization;peptidyl-asparagine modification;peptidyl-amino acid modification;positive regulation of molecular function;macromolecule localization;establishment of protein localization;vesicle-mediated transport;protein metabolic process;organic substance biosynthetic process;ER to Golgi vesicle-mediated transport;positive regulation of GTPase activity;positive regulation of hydrolase activity;intracellular protein transport;Golgi vesicle transport;cellular component organization;biological regulation;positive regulation of catalytic activity;regulation of molecular function;transport;protein secretion;regulation of catalytic activity;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;regulation of hydrolase activity;secretion;intracellular transport;single-organism transport;macromolecule glycosylation;cellular biosynthetic process;cellular macromolecule biosynthetic process;regulation of GTPase activity;single-organism process;post-translational protein modification;cellular process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;secretion by cell;macromolecule metabolic process;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;organic substance metabolic process;organic substance transport;protein N-linked glycosylation via asparagine;cellular protein metabolic process;cellular protein localization;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;primary metabolic process;carbohydrate metabolic process;cellular macromolecule metabolic process;cellular metabolic process;protein transport;single-organism intracellular transport; 4;4;2;3;4;8;7;4;3;4;5;4;4;7;7;6;6;6;3;2;5;3;4;5;4;5;5;1;2;4;3;5;5;5;4;6;4;5;6;2;7;2;5;4;4;4;5;6;4;5;3;5;6;5;5;5;6;3;5;3;4;2;3;3;3;4;4;3;5;5; GO:0005794;GO:0098588;GO:0043231;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0016020;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005575; Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;membrane;cytoplasm;organelle membrane;cell part;cell;cellular_component; 4;4;4;5;3;2;3;3;3;2;4;3;5;3;4;2;4;3;2;2;1; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0005488;GO:0008565;GO:0022892;GO:0043169;GO:0043167;GO:0005215;GO:0060589;GO:0046872;GO:0008047;GO:0030234; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;binding;protein transporter activity;substrate-specific transporter activity;cation binding;ion binding;transporter activity;nucleoside-triphosphatase regulator activity;metal ion binding;enzyme activator activity;enzyme regulator activity; 2;5;5;1;2;4;3;4;3;2;4;5;4;3; K12493 map04144; Endocytosis; IPR001164; Arf GTPase activating protein; nucleus Hs20070255 1068.0 T [T] Signal transduction mechanisms; Q9Y6D5 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3 - [BIG2_HUMAN] 0.861 1.404 0.759 1.251 0.884 1.551 0.613247863 nan 1.415158371 nan 0.540598291 nan 1.754524887 nan GO:0008104;GO:0048583;GO:0007165;GO:0009966;GO:0044707;GO:0051716;GO:0071840;GO:0010256;GO:0044093;GO:0048518;GO:0033036;GO:0051056;GO:0045184;GO:0016192;GO:0044700;GO:0032640;GO:0032940;GO:1903555;GO:0035556;GO:0050789;GO:0043547;GO:0044260;GO:0006887;GO:0016043;GO:0065007;GO:0043085;GO:0032011;GO:0065009;GO:0032760;GO:0006810;GO:0050790;GO:0050794;GO:0008150;GO:0008152;GO:0051234;GO:0051336;GO:0006892;GO:0046903;GO:0046907;GO:0050896;GO:0001819;GO:0051239;GO:0046578;GO:0023052;GO:0023051;GO:0010646;GO:0043087;GO:0044699;GO:1902531;GO:0051240;GO:0006893;GO:0009987;GO:0007032;GO:0007033;GO:0043170;GO:0001816;GO:0001817;GO:1903557;GO:0032012;GO:0032501;GO:0001881;GO:0071704;GO:0071706;GO:0071702;GO:0048193;GO:0044765;GO:0044763;GO:0051649;GO:0007154;GO:0007265;GO:0007264;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0051345;GO:0044237;GO:0032680;GO:0015031;GO:1902582;GO:0043112; protein localization;regulation of response to stimulus;signal transduction;regulation of signal transduction;single-multicellular organism process;cellular response to stimulus;cellular component organization or biogenesis;endomembrane system organization;positive regulation of molecular function;positive regulation of biological process;macromolecule localization;regulation of small GTPase mediated signal transduction;establishment of protein localization;vesicle-mediated transport;single organism signaling;tumor necrosis factor production;secretion by cell;regulation of tumor necrosis factor superfamily cytokine production;intracellular signal transduction;regulation of biological process;positive regulation of GTPase activity;cellular macromolecule metabolic process;exocytosis;cellular component organization;biological regulation;positive regulation of catalytic activity;ARF protein signal transduction;regulation of molecular function;positive regulation of tumor necrosis factor production;transport;regulation of catalytic activity;regulation of cellular process;biological_process;metabolic process;establishment of localization;regulation of hydrolase activity;post-Golgi vesicle-mediated transport;secretion;intracellular transport;response to stimulus;positive regulation of cytokine production;regulation of multicellular organismal process;regulation of Ras protein signal transduction;signaling;regulation of signaling;regulation of cell communication;regulation of GTPase activity;single-organism process;regulation of intracellular signal transduction;positive regulation of multicellular organismal process;Golgi to plasma membrane transport;cellular process;endosome organization;vacuole organization;macromolecule metabolic process;cytokine production;regulation of cytokine production;positive regulation of tumor necrosis factor superfamily cytokine production;regulation of ARF protein signal transduction;multicellular organismal process;receptor recycling;organic substance metabolic process;tumor necrosis factor superfamily cytokine production;organic substance transport;Golgi vesicle transport;single-organism transport;single-organism cellular process;establishment of localization in cell;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;localization;single-organism localization;cellular localization;organelle organization;positive regulation of hydrolase activity;cellular metabolic process;regulation of tumor necrosis factor production;protein transport;single-organism intracellular transport;receptor metabolic process; 4;3;4;4;3;3;2;4;4;2;3;6;4;5;3;6;4;5;5;2;7;4;5;3;2;5;8;3;6;4;4;3;1;2;3;5;7;5;5;2;4;3;7;2;3;4;6;2;5;3;8;2;5;5;4;4;4;5;8;2;4;3;5;5;6;4;3;4;4;7;6;2;3;3;4;6;3;6;5;5;5; GO:0099512;GO:0099513;GO:0030425;GO:0030054;GO:0031984;GO:0031982;GO:0097458;GO:0005773;GO:0016020;GO:0031988;GO:0098588;GO:0036477;GO:0042995;GO:0048471;GO:0043231;GO:0043232;GO:0005829;GO:0044424;GO:0044422;GO:0043228;GO:0005929;GO:0005622;GO:0043227;GO:0005856;GO:0005874;GO:0044431;GO:0044430;GO:0012505;GO:0005930;GO:0000139;GO:0044446;GO:0016023;GO:0044444;GO:0097014;GO:0044441;GO:0097708;GO:0055037;GO:0005879;GO:0005794;GO:0005737;GO:0031090;GO:0031410;GO:0044456;GO:0043005;GO:0032279;GO:0005815;GO:0044463;GO:0044464;GO:0043229;GO:0005623;GO:0032280;GO:0045202;GO:0044447;GO:0044309;GO:0043226;GO:0015630;GO:0043197;GO:0005802;GO:0005575;GO:0098794;GO:0098791;GO:0005768; supramolecular fiber;polymeric cytoskeletal fiber;dendrite;cell junction;organelle subcompartment;vesicle;neuron part;vacuole;membrane;membrane-bounded vesicle;bounding membrane of organelle;somatodendritic compartment;cell projection;perinuclear region of cytoplasm;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;organelle part;non-membrane-bounded organelle;cilium;intracellular;membrane-bounded organelle;cytoskeleton;microtubule;Golgi apparatus part;cytoskeletal part;endomembrane system;axoneme;Golgi membrane;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;ciliary plasm;ciliary part;intracellular vesicle;recycling endosome;axonemal microtubule;Golgi apparatus;cytoplasm;organelle membrane;cytoplasmic vesicle;synapse part;neuron projection;asymmetric synapse;microtubule organizing center;cell projection part;cell part;intracellular organelle;cell;symmetric synapse;synapse;axoneme part;neuron spine;organelle;microtubule cytoskeleton;dendritic spine;trans-Golgi network;cellular_component;postsynapse;Golgi subcompartment;endosome; 2;3;5;2;4;4;3;5;2;5;4;4;3;5;4;4;5;3;2;3;3;3;3;5;4;4;4;3;4;5;3;5;4;4;3;4;5;5;4;4;3;5;2;4;3;5;3;2;3;2;3;2;4;5;2;6;4;5;1;3;5;4; GO:0098772;GO:0005085;GO:0005086;GO:0003674;GO:0005488;GO:0050811;GO:0051018;GO:0005515;GO:0005102;GO:0034237; molecular function regulator;guanyl-nucleotide exchange factor activity;ARF guanyl-nucleotide exchange factor activity;molecular_function;binding;GABA receptor binding;protein kinase A binding;protein binding;receptor binding;protein kinase A regulatory subunit binding; 2;3;4;1;2;5;4;3;4;5; K18442 map04144; Endocytosis; IPR016024;IPR000904;IPR032629;IPR023394;IPR015403;IPR032691;IPR011989; Armadillo-type fold;Sec7 domain;Mon2, dimerisation and cyclophilin-binding domain;Sec7 domain, alpha orthogonal bundle;Sec7, C-terminal;Guanine nucleotide exchange factor, N-terminal;Armadillo-like helical; cytosol Hs5453573 3724.0 U [U] Intracellular trafficking, secretion, and vesicular transport; O94887 FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FARP2 PE=1 SV=3 - [FARP2_HUMAN] 0.949 0.834 1.064 0.989 0.891 2.214 1.137889688 0.437770741 1.109988777 0.394802455 1.275779377 0.215540651 2.484848485 0.308019722 GO:0048468;GO:0048469;GO:0007266;GO:0007165;GO:0007166;GO:0030182;GO:0071840;GO:0051716;GO:0042330;GO:0009966;GO:0048869;GO:0048513;GO:0044093;GO:0051056;GO:0006935;GO:0048583;GO:0042221;GO:0097485;GO:0033622;GO:0044700;GO:0044707;GO:0071526;GO:0002376;GO:0048858;GO:0022607;GO:0035023;GO:0006928;GO:0050789;GO:0031175;GO:0035556;GO:0021700;GO:0009653;GO:0043547;GO:0016601;GO:0042551;GO:0016043;GO:0065003;GO:0065007;GO:0043085;GO:0065009;GO:0061564;GO:0050790;GO:0050794;GO:0051128;GO:0008150;GO:0048731;GO:0043254;GO:1902531;GO:0002521;GO:0002520;GO:0051336;GO:0050896;GO:0048812;GO:0070271;GO:0030154;GO:0046578;GO:0023052;GO:0023051;GO:0007411;GO:0010646;GO:0043087;GO:0022008;GO:0044699;GO:0071800;GO:0070925;GO:0030030;GO:0022610;GO:0032502;GO:0032501;GO:0030316;GO:0016322;GO:0040011;GO:0007409;GO:0032990;GO:0030099;GO:0030097;GO:0043933;GO:0030036;GO:0007275;GO:0071822;GO:0031532;GO:0002573;GO:0048534;GO:0033623;GO:0009605;GO:0048666;GO:0048667;GO:0009987;GO:0030029;GO:0006461;GO:0044767;GO:0000904;GO:0044763;GO:0007155;GO:0007154;GO:0007265;GO:0007264;GO:0000902;GO:0006996;GO:0048699;GO:0007010;GO:0051345;GO:0007399;GO:0048856;GO:0044087;GO:1902589;GO:0044085;GO:0032989; cell development;cell maturation;Rho protein signal transduction;signal transduction;cell surface receptor signaling pathway;neuron differentiation;cellular component organization or biogenesis;cellular response to stimulus;taxis;regulation of signal transduction;cellular developmental process;animal organ development;positive regulation of molecular function;regulation of small GTPase mediated signal transduction;chemotaxis;regulation of response to stimulus;response to chemical;neuron projection guidance;integrin activation;single organism signaling;single-multicellular organism process;semaphorin-plexin signaling pathway;immune system process;cell projection morphogenesis;cellular component assembly;regulation of Rho protein signal transduction;movement of cell or subcellular component;regulation of biological process;neuron projection development;intracellular signal transduction;developmental maturation;anatomical structure morphogenesis;positive regulation of GTPase activity;Rac protein signal transduction;neuron maturation;cellular component organization;macromolecular complex assembly;biological regulation;positive regulation of catalytic activity;regulation of molecular function;axon development;regulation of catalytic activity;regulation of cellular process;regulation of cellular component organization;biological_process;system development;regulation of protein complex assembly;regulation of intracellular signal transduction;leukocyte differentiation;immune system development;regulation of hydrolase activity;response to stimulus;neuron projection morphogenesis;protein complex biogenesis;cell differentiation;regulation of Ras protein signal transduction;signaling;regulation of signaling;axon guidance;regulation of cell communication;regulation of GTPase activity;neurogenesis;single-organism process;podosome assembly;organelle assembly;cell projection organization;biological adhesion;developmental process;multicellular organismal process;osteoclast differentiation;neuron remodeling;locomotion;axonogenesis;cell part morphogenesis;myeloid cell differentiation;hemopoiesis;macromolecular complex subunit organization;actin cytoskeleton organization;multicellular organism development;protein complex subunit organization;actin cytoskeleton reorganization;myeloid leukocyte differentiation;hematopoietic or lymphoid organ development;regulation of integrin activation;response to external stimulus;neuron development;cell morphogenesis involved in neuron differentiation;cellular process;actin filament-based process;protein complex assembly;single-organism developmental process;cell morphogenesis involved in differentiation;single-organism cellular process;cell adhesion;cell communication;Ras protein signal transduction;small GTPase mediated signal transduction;cell morphogenesis;organelle organization;generation of neurons;cytoskeleton organization;positive regulation of hydrolase activity;nervous system development;anatomical structure development;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;cellular component morphogenesis; 4;5;8;4;5;6;2;3;3;4;4;4;4;6;4;3;3;5;6;3;3;6;2;5;4;8;4;2;5;5;4;3;7;8;6;3;5;2;5;3;6;4;3;4;1;4;4;5;6;3;5;2;6;4;5;7;2;3;6;4;6;6;2;6;5;4;2;2;2;8;7;2;7;5;6;5;4;5;4;5;6;7;4;5;3;5;6;2;4;5;3;5;3;3;4;7;6;5;4;7;5;6;5;3;3;4;3;4; GO:0016020;GO:0043232;GO:0005829;GO:0044424;GO:0044425;GO:0043229;GO:0043228;GO:0043226;GO:0005856;GO:0044444;GO:0019898;GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575; membrane;intracellular non-membrane-bounded organelle;cytosol;intracellular part;membrane part;intracellular organelle;non-membrane-bounded organelle;organelle;cytoskeleton;cytoplasmic part;extrinsic component of membrane;cytoplasm;cell part;cell;intracellular;cellular_component; 2;4;5;3;2;3;3;2;5;4;3;4;2;2;3;1; GO:0098772;GO:0005089;GO:0005088;GO:0005085;GO:0003674;GO:0030676; molecular function regulator;Rho guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;molecular_function;Rac guanyl-nucleotide exchange factor activity; 2;5;4;3;1;6; K06082 map04015;map04520; Rap1 signaling pathway;Adherens junction; IPR000219;IPR019749;IPR019748;IPR019747;IPR029071;IPR014847;IPR018979;IPR000798;IPR014352;IPR018980;IPR001849;IPR011993;IPR000299; Dbl homology (DH) domain;Band 4.1 domain;FERM central domain;FERM conserved site;Ubiquitin-related domain;FERM adjacent (FA);FERM, N-terminal;Ezrin/radixin/moesin-like;FERM/acyl-CoA-binding protein, 3-helical bundle;FERM, C-terminal PH-like domain;Pleckstrin homology domain;PH domain-like;FERM domain; nucleus Hs7662310 2189.0 T [T] Signal transduction mechanisms; Q5VYS8 Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1 - [TUT7_HUMAN] 1.856 0.769 0.326 1.199 1.212 0.764 2.413524057 nan 0.989273927 nan 0.423927178 nan 0.630363036 nan GO:0044237;GO:0090304;GO:0034641;GO:0006807;GO:0043170;GO:1901360;GO:0006139;GO:0044260;GO:0010467;GO:0071704;GO:0009987;GO:0006725;GO:0031123;GO:0008150;GO:0008152;GO:0046483;GO:0016070;GO:0044238;GO:0006396; cellular metabolic process;nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;organic cyclic compound metabolic process;nucleobase-containing compound metabolic process;cellular macromolecule metabolic process;gene expression;organic substance metabolic process;cellular process;cellular aromatic compound metabolic process;RNA 3'-end processing;biological_process;metabolic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;RNA processing; 3;5;4;3;4;4;4;4;5;3;2;4;7;1;2;4;5;3;6; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0008270;GO:0043167;GO:0016740;GO:0046872;GO:0043169;GO:0044822;GO:0003824;GO:0050265;GO:0016779;GO:0046914;GO:0097159;GO:0003723;GO:0016772;GO:0070569; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;zinc ion binding;ion binding;transferase activity;metal ion binding;cation binding;poly(A) RNA binding;catalytic activity;RNA uridylyltransferase activity;nucleotidyltransferase activity;transition metal ion binding;organic cyclic compound binding;RNA binding;transferase activity, transferring phosphorus-containing groups;uridylyltransferase activity; 1;2;4;3;7;3;3;5;4;6;2;7;5;6;3;5;4;6; K13291 IPR002934;IPR002058;IPR001878;IPR003604; Polymerase, nucleotidyl transferase domain;PAP/25A-associated;Zinc finger, CCHC-type;Matrin/U1-C-like, C2H2-type zinc finger; nucleus Hs13375836 809.0 D [D] Cell cycle control, cell division, chromosome partitioning; P30953 Olfactory receptor 1E1 OS=Homo sapiens OX=9606 GN=OR1E1 PE=3 SV=1 - [OR1E1_HUMAN] 0.773 0.5 2.416 0.727 0.526 0.584 1.546 0.15963093 1.382129278 0.064217992 4.832 0.008389477 1.11026616 0.116345452 GO:0051716;GO:0007165;GO:0007154;GO:0009593;GO:0050789;GO:0065007;GO:0044699;GO:0007186;GO:0032501;GO:0007608;GO:0050877;GO:0007606;GO:0007600;GO:0050794;GO:0050911;GO:0008150;GO:0023052;GO:0042221;GO:0003008;GO:0044700;GO:0051606;GO:0050896;GO:0044763;GO:0009987;GO:0050906;GO:0050907; cellular response to stimulus;signal transduction;cell communication;detection of chemical stimulus;regulation of biological process;biological regulation;single-organism process;G-protein coupled receptor signaling pathway;multicellular organismal process;sensory perception of smell;neurological system process;sensory perception of chemical stimulus;sensory perception;regulation of cellular process;detection of chemical stimulus involved in sensory perception of smell;biological_process;signaling;response to chemical;system process;single organism signaling;detection of stimulus;response to stimulus;single-organism cellular process;cellular process;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception; 3;4;4;4;2;2;2;5;2;7;4;6;5;3;6;1;2;3;3;3;3;2;3;2;4;5; GO:0071944;GO:0031224;GO:0016021;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044425; cell periphery;intrinsic component of membrane;integral component of membrane;membrane;plasma membrane;cell part;cell;cellular_component;membrane part; 3;3;4;2;3;2;2;1;2; GO:0038023;GO:0060089;GO:0003674;GO:0004872;GO:0004871;GO:0004930;GO:0004888;GO:0004984;GO:0099600; signaling receptor activity;molecular transducer activity;molecular_function;receptor activity;signal transducer activity;G-protein coupled receptor activity;transmembrane signaling receptor activity;olfactory receptor activity;transmembrane receptor activity; 3;2;1;3;2;5;4;5;4; K04257 map04740; Olfactory transduction; IPR017452;IPR000276;IPR000725; GPCR, rhodopsin-like, 7TM;G protein-coupled receptor, rhodopsin-like;Olfactory receptor; plasma membrane O94880 PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=2 - [PHF14_HUMAN] 1.198 1.126 0.677 1.232 1.248 0.275 1.063943162 0.54288248 0.987179487 0.621472409 0.601243339 0.097132021 0.220352564 0.00114999 GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:1901362;GO:1901360;GO:0051716;GO:0010605;GO:0009968;GO:0010464;GO:0009966;GO:0048513;GO:0048519;GO:0060541;GO:0060255;GO:2001141;GO:0046483;GO:0044700;GO:0044707;GO:0023057;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0035790;GO:0043170;GO:0050789;GO:0097659;GO:2000791;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:2000647;GO:0018130;GO:0050793;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0060916;GO:0016070;GO:0044767;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0048008;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010646;GO:0010640;GO:0044699;GO:0010642;GO:0006139;GO:0000122;GO:0051241;GO:0072091;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0051093;GO:0051253;GO:0051252;GO:0010629;GO:0051239;GO:0048731;GO:0072089;GO:0042127;GO:0030323;GO:0030324;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0007275;GO:0072201;GO:2000790;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0006357;GO:0010463;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007154;GO:0035295;GO:0044238;GO:0048856;GO:0044237;GO:2000583;GO:2000026;GO:2000584;GO:0048286;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of mesenchymal cell proliferation;regulation of signal transduction;animal organ development;negative regulation of biological process;respiratory system development;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;single organism signaling;single-multicellular organism process;negative regulation of signaling;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;platelet-derived growth factor receptor-alpha signaling pathway;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;negative regulation of mesenchymal cell proliferation involved in lung development;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;negative regulation of stem cell proliferation;heterocycle biosynthetic process;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;mesenchymal cell proliferation involved in lung development;RNA metabolic process;single-organism developmental process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;platelet-derived growth factor receptor signaling pathway;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;regulation of cell communication;regulation of platelet-derived growth factor receptor signaling pathway;single-organism process;negative regulation of platelet-derived growth factor receptor signaling pathway;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of multicellular organismal process;regulation of stem cell proliferation;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;negative regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;regulation of multicellular organismal process;system development;stem cell proliferation;regulation of cell proliferation;respiratory tube development;lung development;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organism development;negative regulation of mesenchymal cell proliferation;regulation of mesenchymal cell proliferation involved in lung development;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;mesenchymal cell proliferation;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;cell communication;tube development;primary metabolic process;anatomical structure development;cellular metabolic process;regulation of platelet-derived growth factor receptor-alpha signaling pathway;regulation of multicellular organismal development;negative regulation of platelet-derived growth factor receptor-alpha signaling pathway;lung alveolus development;negative regulation of cellular process; 4;3;3;3;4;5;6;7;5;4;3;4;4;6;4;4;2;5;4;6;4;3;3;3;5;3;4;3;9;4;2;7;4;4;4;2;7;5;5;3;4;3;1;2;5;5;5;3;5;2;6;5;6;8;5;6;4;4;2;4;5;3;4;5;2;5;4;7;3;5;2;4;2;3;2;4;7;7;6;3;5;5;5;3;4;4;4;4;4;5;5;4;4;5;4;6;5;6;6;3;5;7;5;5;5;5;6;3;5;3;4;4;4;4;3;3;3;6;4;6;4;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:0046872;GO:0008270;GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0046914; metal ion binding;zinc ion binding;molecular_function;binding;cation binding;ion binding;transition metal ion binding; 5;7;1;2;4;3;6; IPR019787;IPR034732;IPR011011;IPR013083;IPR001965;IPR019786; Zinc finger, PHD-finger;Extended PHD (ePHD) domain;Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;Zinc finger, PHD-type;Zinc finger, PHD-type, conserved site; nucleus Hs7662304 1830.0 R [R] General function prediction only; Q9H900 Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2 - [ZWILC_HUMAN] 0.61 0.637 2.287 0.762 0.728 0.552 0.957613815 nan 1.046703297 nan 3.590266876 nan 0.758241758 nan GO:0045930;GO:0000280;GO:1903047;GO:0023052;GO:0007165;GO:0051301;GO:0048523;GO:0035556;GO:0050789;GO:0007049;GO:0051716;GO:0045786;GO:0071840;GO:0022402;GO:1902589;GO:0016043;GO:0065007;GO:0044699;GO:0006996;GO:0000278;GO:0007067;GO:0009987;GO:0007346;GO:0050794;GO:0044763;GO:0048519;GO:0007154;GO:0007264;GO:0044700;GO:0000075;GO:0051726;GO:0050896;GO:0048285;GO:0008150;GO:0007093; negative regulation of mitotic cell cycle;nuclear division;mitotic cell cycle process;signaling;signal transduction;cell division;negative regulation of cellular process;intracellular signal transduction;regulation of biological process;cell cycle;cellular response to stimulus;negative regulation of cell cycle;cellular component organization or biogenesis;cell cycle process;single-organism organelle organization;cellular component organization;biological regulation;single-organism process;organelle organization;mitotic cell cycle;mitotic nuclear division;cellular process;regulation of mitotic cell cycle;regulation of cellular process;single-organism cellular process;negative regulation of biological process;cell communication;small GTPase mediated signal transduction;single organism signaling;cell cycle checkpoint;regulation of cell cycle;response to stimulus;organelle fission;biological_process;mitotic cell cycle checkpoint; 5;6;5;2;4;4;3;5;2;4;3;4;2;4;4;3;2;2;4;5;5;2;5;3;3;2;4;6;3;5;4;2;5;1;6; GO:0043229;GO:0043228;GO:0005737;GO:0044446;GO:0043226;GO:0000776;GO:1990423;GO:0005694;GO:0000779;GO:0000793;GO:0000775;GO:0098687;GO:0000777;GO:0043234;GO:0032991;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044427;GO:0005829;GO:0044422; intracellular organelle;non-membrane-bounded organelle;cytoplasm;intracellular organelle part;organelle;kinetochore;RZZ complex;chromosome;condensed chromosome, centromeric region;condensed chromosome;chromosome, centromeric region;chromosomal region;condensed chromosome kinetochore;protein complex;macromolecular complex;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;chromosomal part;cytosol;organelle part; 3;3;4;3;2;4;4;5;7;6;6;5;5;3;2;4;2;2;3;1;4;3;4;5;2; K11579 IPR018630; RZZ complex, subunit Zwilch; cytosol Hs22055072 1219.0 S [S] Function unknown; Q86VB7 Scavenger receptor cysteine-rich type 1 protein M130 OS=Homo sapiens OX=9606 GN=CD163 PE=1 SV=2 - [C163A_HUMAN] 0.924 0.815 1.357 0.996 0.83 1.164 1.133742331 0.666849648 1.2 0.306364475 1.665030675 0.334686228 1.402409639 0.28634975 GO:0006954;GO:0006810;GO:0006952;GO:0006950;GO:0008150;GO:0002526;GO:0051234;GO:0051179;GO:0006897;GO:0006953;GO:0050896;GO:0006898;GO:0016192; inflammatory response;transport;defense response;response to stress;biological_process;acute inflammatory response;establishment of localization;localization;endocytosis;acute-phase response;response to stimulus;receptor-mediated endocytosis;vesicle-mediated transport; 5;4;4;3;1;6;3;2;6;7;2;7;5; GO:0030139;GO:0043229;GO:0071944;GO:0005887;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0044446;GO:0030666;GO:0031090;GO:0016023;GO:0031410;GO:0098805;GO:0016020;GO:0031988;GO:0044433;GO:0044459;GO:0031226;GO:0098588;GO:0030659;GO:0097708;GO:0012506;GO:0005886;GO:0031982;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044425;GO:0016021;GO:0044422; endocytic vesicle;intracellular organelle;cell periphery;integral component of plasma membrane;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;intracellular organelle part;endocytic vesicle membrane;organelle membrane;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;whole membrane;membrane;membrane-bounded vesicle;cytoplasmic vesicle part;plasma membrane part;intrinsic component of plasma membrane;bounding membrane of organelle;cytoplasmic vesicle membrane;intracellular vesicle;vesicle membrane;plasma membrane;vesicle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;membrane part;integral component of membrane;organelle part; 6;3;3;4;3;2;3;4;3;4;3;5;5;3;2;5;4;3;4;4;5;4;4;3;4;4;2;2;3;1;4;2;3;2;4;2; GO:0038024;GO:0060089;GO:0003674;GO:0004872;GO:0005044; cargo receptor activity;molecular transducer activity;molecular_function;receptor activity;scavenger receptor activity; 4;2;1;3;5; K06545 IPR017448;IPR001190; SRCR-like domain;SRCR domain; plasma membrane Hs19923276 2264.0 R [R] General function prediction only; P29074 Tyrosine-protein phosphatase non-receptor type 4 OS=Homo sapiens OX=9606 GN=PTPN4 PE=1 SV=1 - [PTN4_HUMAN] 0.898 1.11 0.906 1.228 0.979 1.511 0.809009009 nan 1.254341164 nan 0.816216216 nan 1.543411645 nan GO:0016311;GO:0006470;GO:0044237;GO:0043170;GO:0044267;GO:0044260;GO:0071704;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0006796;GO:0006793; dephosphorylation;protein dephosphorylation;cellular metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process; 6;7;3;4;5;4;3;2;6;5;5;1;2;3;4;5;4; GO:0009898;GO:0043229;GO:0043228;GO:0098552;GO:0043226;GO:0005737;GO:0016020;GO:0044459;GO:0005856;GO:0098562;GO:0005886;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0071944;GO:0044424;GO:0044425; cytoplasmic side of plasma membrane;intracellular organelle;non-membrane-bounded organelle;side of membrane;organelle;cytoplasm;membrane;plasma membrane part;cytoskeleton;cytoplasmic side of membrane;plasma membrane;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cell periphery;intracellular part;membrane part; 4;3;3;3;2;4;2;3;5;4;3;4;2;2;3;1;3;3;2; GO:0016791;GO:0016787;GO:0004721;GO:0042578;GO:0003674;GO:0003824;GO:0016788;GO:0004726;GO:0004725; phosphatase activity;hydrolase activity;phosphoprotein phosphatase activity;phosphoric ester hydrolase activity;molecular_function;catalytic activity;hydrolase activity, acting on ester bonds;non-membrane spanning protein tyrosine phosphatase activity;protein tyrosine phosphatase activity; 6;3;7;5;1;2;4;9;8; K18037 IPR001478;IPR016130;IPR018979;IPR019749;IPR012151;IPR029071;IPR029021;IPR003595;IPR019748;IPR014847;IPR014352;IPR000299;IPR019747;IPR018980;IPR011993;IPR000387;IPR000242; PDZ domain;Protein-tyrosine phosphatase, active site;FERM, N-terminal;Band 4.1 domain;Protein-tyrosine phosphatase, non-receptor type-3, -4;Ubiquitin-related domain;Protein-tyrosine phosphatase-like;Protein-tyrosine phosphatase, catalytic;FERM central domain;FERM adjacent (FA);FERM/acyl-CoA-binding protein, 3-helical bundle;FERM domain;FERM conserved site;FERM, C-terminal PH-like domain;PH domain-like;Tyrosine specific protein phosphatases domain;PTP type protein phosphatase; nucleus Hs4506295 1946.0 T [T] Signal transduction mechanisms; P0DOY2 Immunoglobulin lambda constant 2 OS=Homo sapiens OX=9606 GN=IGLC2 PE=1 SV=1 - [IGLC2_HUMAN] 1.066 0.902 1.126 0.885 0.911 0.853 1.181818182 1.04E-09 0.971459934 0.620756447 1.248337029 5.90E-17 0.936333699 4.26E-06 IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular Q15464 SH2 domain-containing adapter protein B OS=Homo sapiens OX=9606 GN=SHB PE=1 SV=2 - [SHB_HUMAN] 0.885 0.957 0.995 1.255 0.994 1.57 0.92476489 nan 1.262575453 nan 1.039707419 nan 1.579476861 nan GO:0048584;GO:0048583;GO:0007275;GO:0030154;GO:0023056;GO:0072359;GO:0007165;GO:0007166;GO:0023051;GO:0007169;GO:0008219;GO:0010646;GO:0010647;GO:0044699;GO:0051716;GO:0009653;GO:0009966;GO:0009967;GO:0001568;GO:0001944;GO:0050789;GO:0065007;GO:0048518;GO:0048514;GO:0048646;GO:0032502;GO:0006915;GO:0007167;GO:0032501;GO:0009987;GO:0048731;GO:0050794;GO:0044767;GO:0012501;GO:0044763;GO:0023052;GO:0007154;GO:0048010;GO:0044700;GO:0044707;GO:0050896;GO:0048856;GO:0072358;GO:0001525;GO:0048869;GO:0008150;GO:0048522; positive regulation of response to stimulus;regulation of response to stimulus;multicellular organism development;cell differentiation;positive regulation of signaling;circulatory system development;signal transduction;cell surface receptor signaling pathway;regulation of signaling;transmembrane receptor protein tyrosine kinase signaling pathway;cell death;regulation of cell communication;positive regulation of cell communication;single-organism process;cellular response to stimulus;anatomical structure morphogenesis;regulation of signal transduction;positive regulation of signal transduction;blood vessel development;vasculature development;regulation of biological process;biological regulation;positive regulation of biological process;blood vessel morphogenesis;anatomical structure formation involved in morphogenesis;developmental process;apoptotic process;enzyme linked receptor protein signaling pathway;multicellular organismal process;cellular process;system development;regulation of cellular process;single-organism developmental process;programmed cell death;single-organism cellular process;signaling;cell communication;vascular endothelial growth factor receptor signaling pathway;single organism signaling;single-multicellular organism process;response to stimulus;anatomical structure development;cardiovascular system development;angiogenesis;cellular developmental process;biological_process;positive regulation of cellular process; 3;3;4;5;3;5;4;5;3;7;4;4;4;2;3;3;4;4;4;5;2;2;2;4;3;2;6;6;2;2;4;3;3;5;3;2;4;8;3;3;2;3;5;4;4;1;3; GO:0071944;GO:0016020;GO:0005737;GO:0005886;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0005829; cell periphery;membrane;cytoplasm;plasma membrane;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;cytosol; 3;2;4;3;2;2;3;1;4;3;5; GO:0003674;GO:0005070;GO:0060090;GO:0030674;GO:0035591;GO:0005515;GO:0005488; molecular_function;SH3/SH2 adaptor activity;binding, bridging;protein binding, bridging;signaling adaptor activity;protein binding;binding; 1;5;3;4;4;3;2; IPR035040;IPR000980;IPR035045; SH2 domain-containing adapter protein B;SH2 domain;SHB, SH2 domain; nucleus P01782 Immunoglobulin heavy variable 3-9 OS=Homo sapiens OX=9606 GN=IGHV3-9 PE=1 SV=2 - [HV309_HUMAN] 1.068 1.115 0.893 1.032 1.176 0.804 0.957847534 0.301137524 0.87755102 0.005726687 0.800896861 0.002023018 0.683673469 0.00104506 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q96FS4 Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1 - [SIPA1_HUMAN] 0.903 1.118 1.15 0.918 1.051 1.063 0.807692308 nan 0.873453853 nan 1.02862254 nan 1.011417697 nan GO:0048583;GO:0007162;GO:0007165;GO:0071840;GO:0051716;GO:0045786;GO:0009966;GO:0044093;GO:0048519;GO:0051056;GO:0010035;GO:0044700;GO:0031668;GO:0009605;GO:0007154;GO:0033554;GO:0070887;GO:0023051;GO:0035556;GO:0050789;GO:0016049;GO:0043547;GO:0051345;GO:0016043;GO:0065007;GO:0043085;GO:0065009;GO:0071214;GO:0050790;GO:0050794;GO:0006950;GO:0008150;GO:0042631;GO:1902531;GO:0051336;GO:0050896;GO:1901701;GO:0071462;GO:0030308;GO:0030155;GO:0051128;GO:0023052;GO:0009414;GO:0009415;GO:0010646;GO:0043087;GO:0044699;GO:0022610;GO:0006996;GO:0071496;GO:0008283;GO:0009987;GO:0001558;GO:0001101;GO:0007049;GO:0009991;GO:0045926;GO:0071229;GO:0040007;GO:0040008;GO:0044763;GO:0007155;GO:0042221;GO:0007264;GO:1901700;GO:0009628;GO:0007010;GO:0051726;GO:0048523; regulation of response to stimulus;negative regulation of cell adhesion;signal transduction;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of cell cycle;regulation of signal transduction;positive regulation of molecular function;negative regulation of biological process;regulation of small GTPase mediated signal transduction;response to inorganic substance;single organism signaling;cellular response to extracellular stimulus;response to external stimulus;cell communication;cellular response to stress;cellular response to chemical stimulus;regulation of signaling;intracellular signal transduction;regulation of biological process;cell growth;positive regulation of GTPase activity;positive regulation of hydrolase activity;cellular component organization;biological regulation;positive regulation of catalytic activity;regulation of molecular function;cellular response to abiotic stimulus;regulation of catalytic activity;regulation of cellular process;response to stress;biological_process;cellular response to water deprivation;regulation of intracellular signal transduction;regulation of hydrolase activity;response to stimulus;cellular response to oxygen-containing compound;cellular response to water stimulus;negative regulation of cell growth;regulation of cell adhesion;regulation of cellular component organization;signaling;response to water deprivation;response to water;regulation of cell communication;regulation of GTPase activity;single-organism process;biological adhesion;organelle organization;cellular response to external stimulus;cell proliferation;cellular process;regulation of cell growth;response to acid chemical;cell cycle;response to extracellular stimulus;negative regulation of growth;cellular response to acid chemical;growth;regulation of growth;single-organism cellular process;cell adhesion;response to chemical;small GTPase mediated signal transduction;response to oxygen-containing compound;response to abiotic stimulus;cytoskeleton organization;regulation of cell cycle;negative regulation of cellular process; 3;4;4;2;3;4;4;4;2;6;4;3;4;3;4;4;4;3;5;2;3;7;6;3;2;5;3;4;4;3;3;1;5;5;5;2;5;5;4;4;4;2;4;4;4;6;2;2;4;4;3;2;4;4;4;4;3;5;2;3;3;3;3;6;4;3;5;4;3; GO:0031982;GO:0016020;GO:0031988;GO:0048471;GO:0043234;GO:0043231;GO:0005829;GO:0044424;GO:0043229;GO:0043227;GO:0012505;GO:0016023;GO:0044444;GO:0097708;GO:0005737;GO:0031410;GO:0005634;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0030133;GO:0043226;GO:0005575; vesicle;membrane;membrane-bounded vesicle;perinuclear region of cytoplasm;protein complex;intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;membrane-bounded organelle;endomembrane system;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;intracellular vesicle;cytoplasm;cytoplasmic vesicle;nucleus;macromolecular complex;cell part;cell;intracellular;transport vesicle;organelle;cellular_component; 4;2;5;5;3;4;5;3;3;3;3;5;4;4;4;5;5;2;2;2;3;4;2;1; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;5;5;1;4;4;3; K08013 map04015;map04670; Rap1 signaling pathway;Leukocyte transendothelial migration; IPR001478;IPR000331; PDZ domain;Rap GTPase activating protein domain; nucleus Hs22062502 2096.0 T [T] Signal transduction mechanisms; P01780 Immunoglobulin heavy variable 3-7 OS=Homo sapiens OX=9606 GN=IGHV3-7 PE=1 SV=2 - [HV307_HUMAN] 1.226 0.96 0.923 0.991 1.054 0.763 1.277083333 8.87E-09 0.940227704 0.094747982 0.961458333 0.078011736 0.723908918 0.944736085 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9NVZ3 Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1 - [NECP2_HUMAN] 0.815 0.541 1.962 0.822 0.53 1.994 1.506469501 nan 1.550943396 nan 3.626617375 nan 3.762264151 nan GO:0008104;GO:0071702;GO:0033036;GO:0006810;GO:0045184;GO:0008150;GO:0051234;GO:0051179;GO:0006897;GO:0016192;GO:0015031; protein localization;organic substance transport;macromolecule localization;transport;establishment of protein localization;biological_process;establishment of localization;localization;endocytosis;vesicle-mediated transport;protein transport; 4;5;3;4;4;1;3;2;6;5;5; GO:0043231;GO:0043229;GO:0071944;GO:0030117;GO:0005905;GO:0044424;GO:0030118;GO:0043227;GO:0043226;GO:0030136;GO:0005737;GO:0044446;GO:0031982;GO:0030662;GO:0016023;GO:0030135;GO:0098805;GO:0016020;GO:0031988;GO:0044433;GO:0048475;GO:0030665;GO:0098588;GO:0098589;GO:0030659;GO:0012505;GO:0012506;GO:0005886;GO:0032991;GO:0030120;GO:0030125;GO:0043234;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0098796;GO:0044444;GO:0031090;GO:0031410;GO:0044425;GO:0044422;GO:0097708; intracellular membrane-bounded organelle;intracellular organelle;cell periphery;membrane coat;coated pit;intracellular part;clathrin coat;membrane-bounded organelle;organelle;clathrin-coated vesicle;cytoplasm;intracellular organelle part;vesicle;coated vesicle membrane;cytoplasmic, membrane-bounded vesicle;coated vesicle;whole membrane;membrane;membrane-bounded vesicle;cytoplasmic vesicle part;coated membrane;clathrin-coated vesicle membrane;bounding membrane of organelle;membrane region;cytoplasmic vesicle membrane;endomembrane system;vesicle membrane;plasma membrane;macromolecular complex;vesicle coat;clathrin vesicle coat;protein complex;cell part;cell;intracellular;cellular_component;membrane protein complex;cytoplasmic part;organelle membrane;cytoplasmic vesicle;membrane part;organelle part;intracellular vesicle; 4;3;3;4;3;3;5;3;2;7;4;3;4;4;5;6;3;2;5;4;3;5;4;3;5;3;4;3;2;5;6;3;2;2;3;1;3;4;3;5;2;2;4; K20069 IPR012466;IPR011993; NECAP, PHear domain;PH domain-like; cytosol Hs8922416 537.0 S [S] Function unknown; P02774 Vitamin D-binding protein OS=Homo sapiens OX=9606 GN=GC PE=1 SV=2 - [VTDB_HUMAN] 1.058 0.983 0.915 1.061 1.004 1.048 1.07629705 2.48E-06 1.056772908 1.66E-11 0.930824008 0.000243937 1.043824701 2.36E-28 GO:0006775;GO:0007595;GO:0044281;GO:0044707;GO:1901360;GO:0044710;GO:0000003;GO:0071704;GO:0048513;GO:0065007;GO:0006766;GO:0010033;GO:0051704;GO:0044703;GO:0009605;GO:0044706;GO:0031667;GO:0007565;GO:0032941;GO:0051180;GO:0044699;GO:0065008;GO:0030879;GO:0006629;GO:0006810;GO:0008150;GO:0008152;GO:0051234;GO:0046903;GO:0050896;GO:0097305;GO:1901615;GO:0014070;GO:0009719;GO:0032502;GO:0032501;GO:0050878;GO:0008202;GO:0009725;GO:0006066;GO:0048731;GO:0048732;GO:0048545;GO:0009991;GO:0007275;GO:0032355;GO:0033993;GO:0007589;GO:0044767;GO:0022414;GO:0044765;GO:0043627;GO:0042221;GO:0051179;GO:1902578;GO:0042359;GO:1901700;GO:0044238;GO:0048856; fat-soluble vitamin metabolic process;lactation;small molecule metabolic process;single-multicellular organism process;organic cyclic compound metabolic process;single-organism metabolic process;reproduction;organic substance metabolic process;animal organ development;biological regulation;vitamin metabolic process;response to organic substance;multi-organism process;multi-organism reproductive process;response to external stimulus;multi-multicellular organism process;response to nutrient levels;female pregnancy;secretion by tissue;vitamin transport;single-organism process;regulation of biological quality;mammary gland development;lipid metabolic process;transport;biological_process;metabolic process;establishment of localization;secretion;response to stimulus;response to alcohol;organic hydroxy compound metabolic process;response to organic cyclic compound;response to endogenous stimulus;developmental process;multicellular organismal process;regulation of body fluid levels;steroid metabolic process;response to hormone;alcohol metabolic process;system development;gland development;response to steroid hormone;response to extracellular stimulus;multicellular organism development;response to estradiol;response to lipid;body fluid secretion;single-organism developmental process;reproductive process;single-organism transport;response to estrogen;response to chemical;localization;single-organism localization;vitamin D metabolic process;response to oxygen-containing compound;primary metabolic process;anatomical structure development; 6;5;4;3;4;3;2;3;4;2;5;4;2;3;3;3;5;4;4;5;2;3;5;4;4;1;2;3;5;2;5;4;5;3;2;2;4;5;4;5;4;4;5;4;4;6;5;5;3;2;4;6;3;2;3;6;4;3;3; GO:0031974;GO:0030424;GO:0043202;GO:0005773;GO:0005775;GO:0042995;GO:0043230;GO:0043231;GO:0005829;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0072562;GO:0044437;GO:0048471;GO:0005737;GO:0031982;GO:0044446;GO:0044444;GO:0000323;GO:0043005;GO:0044464;GO:0005623;GO:0005622;GO:0005764;GO:0005615;GO:0070062;GO:0097458;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;axon;lysosomal lumen;vacuole;vacuolar lumen;cell projection;extracellular organelle;intracellular membrane-bounded organelle;cytosol;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;blood microparticle;vacuolar part;perinuclear region of cytoplasm;cytoplasm;vesicle;intracellular organelle part;cytoplasmic part;lytic vacuole;neuron projection;cell part;cell;intracellular;lysosome;extracellular space;extracellular exosome;neuron part;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;5;6;5;5;3;3;4;5;3;3;2;2;3;3;2;3;4;5;4;4;3;4;6;4;2;2;3;7;3;4;3;3;1;4;2; GO:0005499;GO:0005496;GO:0003674;GO:0005488;GO:0051183;GO:0003779;GO:0036094;GO:0008092;GO:0097159;GO:0005215;GO:0008289;GO:0043178;GO:0005515;GO:1902271;GO:1902118;GO:0019842; vitamin D binding;steroid binding;molecular_function;binding;vitamin transporter activity;actin binding;small molecule binding;cytoskeletal protein binding;organic cyclic compound binding;transporter activity;lipid binding;alcohol binding;protein binding;D3 vitamins binding;calcidiol binding;vitamin binding; 5;4;1;2;3;5;3;4;3;2;3;4;3;6;7;4; K12258 IPR000264;IPR020857;IPR020858;IPR000213;IPR015247;IPR014760; ALB/AFP/VDB;Serum albumin, conserved site;Serum albumin-like;Vitamin D-binding protein;Vitamin D binding protein, domain III;Serum albumin, N-terminal; extracellular P33151 Cadherin-5 OS=Homo sapiens OX=9606 GN=CDH5 PE=1 SV=5 - [CADH5_HUMAN] 0.917 1.014 1.121 1.114 0.927 1.015 0.90433925 0.572811667 1.201725998 0.123007708 1.105522682 0.523141955 1.094929881 0.302132042 GO:0048468;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0061028;GO:0051716;GO:0048869;GO:0071695;GO:1901550;GO:1901552;GO:0030856;GO:0007179;GO:0010720;GO:0030855;GO:0048518;GO:0048519;GO:0030858;GO:0002064;GO:0042127;GO:0023052;GO:0010033;GO:0098742;GO:0007178;GO:0044700;GO:0044707;GO:0071310;GO:0007163;GO:1903140;GO:1903142;GO:0022607;GO:0030010;GO:0021700;GO:0001568;GO:0016043;GO:0098609;GO:0065007;GO:0071840;GO:0098602;GO:0050793;GO:0009888;GO:0050794;GO:0008150;GO:0051239;GO:0048010;GO:0050896;GO:0003158;GO:0030154;GO:0070848;GO:0007043;GO:0070887;GO:0042221;GO:0009719;GO:0001944;GO:0060284;GO:0022610;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0060429;GO:0045597;GO:0045595;GO:0045216;GO:0032878;GO:0034329;GO:0044699;GO:0071363;GO:0051094;GO:0001955;GO:0071560;GO:0048731;GO:0071495;GO:0016337;GO:0034332;GO:0034330;GO:0001885;GO:0045446;GO:0007275;GO:2000114;GO:0050789;GO:0045603;GO:0045601;GO:0071559;GO:0009987;GO:0044767;GO:0044763;GO:0007155;GO:0007154;GO:0007156;GO:0048856;GO:0044085;GO:2000026;GO:0048523;GO:0048522; cell development;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;establishment of endothelial barrier;cellular response to stimulus;cellular developmental process;anatomical structure maturation;regulation of endothelial cell development;positive regulation of endothelial cell development;regulation of epithelial cell differentiation;transforming growth factor beta receptor signaling pathway;positive regulation of cell development;epithelial cell differentiation;positive regulation of biological process;negative regulation of biological process;positive regulation of epithelial cell differentiation;epithelial cell development;regulation of cell proliferation;signaling;response to organic substance;cell-cell adhesion via plasma-membrane adhesion molecules;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;single-multicellular organism process;cellular response to organic substance;establishment or maintenance of cell polarity;regulation of establishment of endothelial barrier;positive regulation of establishment of endothelial barrier;cellular component assembly;establishment of cell polarity;developmental maturation;blood vessel development;cellular component organization;cell-cell adhesion;biological regulation;cellular component organization or biogenesis;single organism cell adhesion;regulation of developmental process;tissue development;regulation of cellular process;biological_process;regulation of multicellular organismal process;vascular endothelial growth factor receptor signaling pathway;response to stimulus;endothelium development;cell differentiation;response to growth factor;cell-cell junction assembly;cellular response to chemical stimulus;response to chemical;response to endogenous stimulus;vasculature development;regulation of cell development;biological adhesion;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;epithelium development;positive regulation of cell differentiation;regulation of cell differentiation;cell-cell junction organization;regulation of establishment or maintenance of cell polarity;cell junction assembly;single-organism process;cellular response to growth factor stimulus;positive regulation of developmental process;blood vessel maturation;cellular response to transforming growth factor beta stimulus;system development;cellular response to endogenous stimulus;single organismal cell-cell adhesion;adherens junction organization;cell junction organization;endothelial cell development;endothelial cell differentiation;multicellular organism development;regulation of establishment of cell polarity;regulation of biological process;positive regulation of endothelial cell differentiation;regulation of endothelial cell differentiation;response to transforming growth factor beta;cellular process;single-organism developmental process;single-organism cellular process;cell adhesion;cell communication;homophilic cell adhesion via plasma membrane adhesion molecules;anatomical structure development;cellular component biogenesis;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process; 4;5;5;4;5;6;7;7;3;4;4;6;6;5;6;5;6;2;2;5;5;4;2;4;5;7;3;3;5;4;7;7;4;5;4;4;3;4;2;2;3;3;4;3;1;3;8;2;6;5;5;6;4;3;3;5;5;2;2;4;2;3;5;4;4;5;4;5;2;6;3;5;5;4;4;4;6;4;6;7;4;5;2;6;6;4;2;3;3;3;4;6;3;3;4;3;3; GO:0005911;GO:0030054;GO:0016021;GO:0016020;GO:0044425;GO:0009897;GO:0005923;GO:0070160;GO:0070161;GO:0031224;GO:0044459;GO:0009986;GO:0005912;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0005886;GO:0005575;GO:0043296; cell-cell junction;cell junction;integral component of membrane;membrane;membrane part;external side of plasma membrane;bicellular tight junction;occluding junction;anchoring junction;intrinsic component of membrane;plasma membrane part;cell surface;adherens junction;cell part;cell;cell periphery;side of membrane;plasma membrane;cellular_component;apical junction complex; 3;2;4;2;2;4;5;4;3;3;3;3;4;2;2;3;3;3;1;4; GO:0044325;GO:0046872;GO:0003674;GO:0005488;GO:0008013;GO:0043169;GO:0043167;GO:0005509;GO:0005515;GO:0005102; ion channel binding;metal ion binding;molecular_function;binding;beta-catenin binding;cation binding;ion binding;calcium ion binding;protein binding;receptor binding; 4;5;1;2;4;4;3;6;3;4; K06533 map04514;map04670; Cell adhesion molecules (CAMs);Leukocyte transendothelial migration; IPR002126;IPR000233;IPR020894;IPR015919;IPR030052;IPR027397; Cadherin;Cadherin, cytoplasmic domain;Cadherin conserved site;Cadherin-like;VE-cadherin;Catenin binding domain; plasma membrane Hs4502727 1630.0 S [S] Function unknown; Q6PF04 Zinc finger protein 613 OS=Homo sapiens OX=9606 GN=ZNF613 PE=2 SV=2 - [ZN613_HUMAN] 1.269 1.015 0.798 1.099 1.118 0.769 1.250246305 nan 0.983005367 nan 0.786206897 nan 0.68783542 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0010604;GO:0048518;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0019438;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0051254;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0006139;GO:0000122;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0045893;GO:0051253;GO:0051252;GO:0010629;GO:1902680;GO:0010628;GO:0045944;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0051173;GO:0044238;GO:0044237;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;aromatic compound biosynthetic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of RNA metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;5;4;4;4;2;2;4;6;4;5;3;3;4;4;5;3;4;2;7;4;4;2;7;5;4;3;1;2;5;5;5;6;5;5;6;5;6;4;4;5;4;7;7;2;4;7;7;6;6;5;5;5;6;5;7;5;5;5;4;4;4;5;6;6;3;5;7;5;5;5;5;6;3;5;4;4;4;3;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:0001071;GO:1901363;GO:0046872;GO:0001067;GO:0044212;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0043169;GO:0097159;GO:0000975;GO:0043167;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;metal ion binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;molecular_function;binding;nucleic acid binding;DNA binding;cation binding;organic cyclic compound binding;regulatory region DNA binding;ion binding;transcription factor activity, sequence-specific DNA binding; 2;3;5;5;7;1;2;4;5;4;3;6;3;3; K09228 IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs21362003 1204.0 R [R] General function prediction only; P19338 Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3 - [NUCL_HUMAN] 0.568 0.713 2.223 0.879 0.686 0.544 0.796633941 nan 1.281341108 nan 3.117812062 nan 0.793002915 nan GO:0008104;GO:0080090;GO:0019222;GO:0051047;GO:0051049;GO:0032675;GO:0072359;GO:0072358;GO:0032940;GO:1901362;GO:1901360;GO:0051716;GO:0043207;GO:0071704;GO:0009617;GO:0043067;GO:0042981;GO:0071706;GO:0048514;GO:0051223;GO:0048518;GO:0048519;GO:0016192;GO:0006364;GO:1902680;GO:0034470;GO:0010467;GO:0060255;GO:0060548;GO:0034645;GO:0007283;GO:0051222;GO:2001141;GO:0031100;GO:0051707;GO:0010033;GO:0051704;GO:0044703;GO:0044702;GO:0009607;GO:0044707;GO:0010468;GO:0050789;GO:0019438;GO:0033036;GO:0032640;GO:0009891;GO:0070201;GO:0008152;GO:0034660;GO:0032496;GO:0043170;GO:0097659;GO:0090069;GO:1901576;GO:1904951;GO:0050708;GO:0044260;GO:0006357;GO:0001568;GO:0050707;GO:0042254;GO:0006360;GO:0045943;GO:0065007;GO:0071840;GO:0071219;GO:0006366;GO:0071216;GO:0032880;GO:2000232;GO:0048646;GO:0018130;GO:0032760;GO:2000778;GO:0006139;GO:0009306;GO:0006810;GO:0009889;GO:0009303;GO:0050794;GO:0012501;GO:0008150;GO:0051239;GO:0034654;GO:0032755;GO:0051234;GO:0010604;GO:0016070;GO:0016072;GO:0046483;GO:0050715;GO:0050714;GO:0050896;GO:0044765;GO:0006355;GO:0010556;GO:0006351;GO:0051046;GO:0001819;GO:0051240;GO:0044085;GO:0072604;GO:0032774;GO:0031099;GO:0019953;GO:0045944;GO:0044249;GO:0034641;GO:1903530;GO:0070887;GO:1903532;GO:0009653;GO:0000003;GO:0044699;GO:0009893;GO:0010557;GO:0061008;GO:0001944;GO:0048513;GO:0022613;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0044238;GO:0045184;GO:0009987;GO:0071396;GO:0046903;GO:1903506;GO:1903557;GO:0045893;GO:0048232;GO:0044271;GO:0032879;GO:0044087;GO:0051252;GO:0051254;GO:0001816;GO:0001817;GO:0006807;GO:0002237;GO:0097421;GO:0048731;GO:0048732;GO:0042790;GO:0015031;GO:1903508;GO:0071222;GO:1903555;GO:0060341;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0032635;GO:0001889;GO:0006897;GO:0008219;GO:0001525;GO:0007275;GO:0007276;GO:0010628;GO:0050663;GO:0010941;GO:0032680;GO:0033993;GO:2000112;GO:0006356;GO:0098781;GO:0071310;GO:0043066;GO:0071702;GO:0043069;GO:0009605;GO:0045935;GO:0019219;GO:0006725;GO:0006915;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0042221;GO:0051179;GO:1902578;GO:0051641;GO:1901700;GO:1901701;GO:0048856;GO:0044237;GO:0006396;GO:1901838;GO:0051050;GO:1901836;GO:0048523;GO:0048522; protein localization;regulation of primary metabolic process;regulation of metabolic process;positive regulation of secretion;regulation of transport;regulation of interleukin-6 production;circulatory system development;cardiovascular system development;secretion by cell;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;response to external biotic stimulus;organic substance metabolic process;response to bacterium;regulation of programmed cell death;regulation of apoptotic process;tumor necrosis factor superfamily cytokine production;blood vessel morphogenesis;regulation of protein transport;positive regulation of biological process;negative regulation of biological process;vesicle-mediated transport;rRNA processing;positive regulation of RNA biosynthetic process;ncRNA processing;gene expression;regulation of macromolecule metabolic process;negative regulation of cell death;cellular macromolecule biosynthetic process;spermatogenesis;positive regulation of protein transport;regulation of RNA biosynthetic process;organ regeneration;response to other organism;response to organic substance;multi-organism process;multi-organism reproductive process;single organism reproductive process;response to biotic stimulus;single-multicellular organism process;regulation of gene expression;regulation of biological process;aromatic compound biosynthetic process;macromolecule localization;tumor necrosis factor production;positive regulation of biosynthetic process;regulation of establishment of protein localization;metabolic process;ncRNA metabolic process;response to lipopolysaccharide;macromolecule metabolic process;nucleic acid-templated transcription;regulation of ribosome biogenesis;organic substance biosynthetic process;positive regulation of establishment of protein localization;regulation of protein secretion;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;blood vessel development;regulation of cytokine secretion;ribosome biogenesis;transcription from RNA polymerase I promoter;positive regulation of transcription from RNA polymerase I promoter;biological regulation;cellular component organization or biogenesis;cellular response to molecule of bacterial origin;transcription from RNA polymerase II promoter;cellular response to biotic stimulus;regulation of protein localization;regulation of rRNA processing;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;positive regulation of tumor necrosis factor production;positive regulation of interleukin-6 secretion;nucleobase-containing compound metabolic process;protein secretion;transport;regulation of biosynthetic process;rRNA transcription;regulation of cellular process;programmed cell death;biological_process;regulation of multicellular organismal process;nucleobase-containing compound biosynthetic process;positive regulation of interleukin-6 production;establishment of localization;positive regulation of macromolecule metabolic process;RNA metabolic process;rRNA metabolic process;heterocycle metabolic process;positive regulation of cytokine secretion;positive regulation of protein secretion;response to stimulus;single-organism transport;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;regulation of secretion;positive regulation of cytokine production;positive regulation of multicellular organismal process;cellular component biogenesis;interleukin-6 secretion;RNA biosynthetic process;regeneration;sexual reproduction;positive regulation of transcription from RNA polymerase II promoter;cellular biosynthetic process;cellular nitrogen compound metabolic process;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;anatomical structure morphogenesis;reproduction;single-organism process;positive regulation of metabolic process;positive regulation of macromolecule biosynthetic process;hepaticobiliary system development;vasculature development;animal organ development;ribonucleoprotein complex biogenesis;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;primary metabolic process;establishment of protein localization;cellular process;cellular response to lipid;secretion;regulation of nucleic acid-templated transcription;positive regulation of tumor necrosis factor superfamily cytokine production;positive regulation of transcription, DNA-templated;male gamete generation;cellular nitrogen compound biosynthetic process;regulation of localization;regulation of cellular component biogenesis;regulation of RNA metabolic process;positive regulation of RNA metabolic process;cytokine production;regulation of cytokine production;nitrogen compound metabolic process;response to molecule of bacterial origin;liver regeneration;system development;gland development;transcription of nuclear large rRNA transcript from RNA polymerase I promoter;protein transport;positive regulation of nucleic acid-templated transcription;cellular response to lipopolysaccharide;regulation of tumor necrosis factor superfamily cytokine production;regulation of cellular localization;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;interleukin-6 production;liver development;endocytosis;cell death;angiogenesis;multicellular organism development;gamete generation;positive regulation of gene expression;cytokine secretion;regulation of cell death;regulation of tumor necrosis factor production;response to lipid;regulation of cellular macromolecule biosynthetic process;regulation of transcription from RNA polymerase I promoter;ncRNA transcription;cellular response to organic substance;negative regulation of apoptotic process;organic substance transport;negative regulation of programmed cell death;response to external stimulus;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;apoptotic process;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;localization;single-organism localization;cellular localization;response to oxygen-containing compound;cellular response to oxygen-containing compound;anatomical structure development;cellular metabolic process;RNA processing;positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;positive regulation of transport;regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter;negative regulation of cellular process;positive regulation of cellular process; 4;4;3;4;4;5;5;5;4;5;4;3;4;3;4;5;6;5;4;5;2;2;5;6;6;7;5;4;4;5;6;4;6;5;3;4;2;3;3;3;3;5;2;5;3;6;4;5;2;6;5;4;7;4;4;3;6;4;7;4;5;5;7;7;2;2;5;7;4;4;5;3;5;6;6;4;5;4;4;8;3;5;1;3;5;5;3;4;5;7;4;5;5;2;4;6;5;6;5;4;3;3;6;6;4;3;7;4;4;5;4;4;3;2;2;3;5;5;5;4;4;2;2;3;3;3;4;2;6;5;7;5;6;5;5;3;3;5;5;4;4;3;5;6;4;4;8;5;7;6;5;4;5;5;4;4;5;5;5;6;4;4;4;4;5;5;4;6;5;6;7;7;5;6;5;5;3;5;5;4;6;3;2;3;5;3;4;4;3;2;3;3;4;5;3;3;6;8;3;8;3;3; GO:0031974;GO:0035770;GO:0031982;GO:0043230;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:1990904;GO:0043232;GO:0043229;GO:0043228;GO:0036464;GO:0043227;GO:0043226;GO:0005654;GO:0099568;GO:0005938;GO:0031981;GO:0044446;GO:0044444;GO:0016020;GO:0005737;GO:0005730;GO:0005634;GO:0044452;GO:0001650;GO:0001651;GO:0009986;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0030529;GO:1903561;GO:0032991;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;ribonucleoprotein granule;vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;extracellular region part;organelle part;ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cytoplasmic ribonucleoprotein granule;membrane-bounded organelle;organelle;nucleoplasm;cytoplasmic region;cell cortex;nuclear lumen;intracellular organelle part;cytoplasmic part;membrane;cytoplasm;nucleolus;nucleus;nucleolar part;fibrillar center;dense fibrillar component;cell surface;cell part;cell;intracellular;cell periphery;extracellular exosome;intracellular ribonucleoprotein complex;extracellular vesicle;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 2;5;4;3;4;3;4;3;2;2;3;4;3;3;5;3;2;5;5;4;5;3;4;2;4;5;5;5;6;6;3;2;2;3;3;4;4;3;2;1;4;2; GO:0042134;GO:1901363;GO:0000166;GO:0046872;GO:0003674;GO:0003676;GO:0003677;GO:0036094;GO:0097159;GO:0008022;GO:0043169;GO:0043565;GO:0043167;GO:0005509;GO:0003697;GO:0042802;GO:0042162;GO:0044822;GO:0003729;GO:0003723;GO:0005515;GO:0005488;GO:0035368;GO:1901265;GO:0019843; rRNA primary transcript binding;heterocyclic compound binding;nucleotide binding;metal ion binding;molecular_function;nucleic acid binding;DNA binding;small molecule binding;organic cyclic compound binding;protein C-terminus binding;cation binding;sequence-specific DNA binding;ion binding;calcium ion binding;single-stranded DNA binding;identical protein binding;telomeric DNA binding;poly(A) RNA binding;mRNA binding;RNA binding;protein binding;binding;selenocysteine insertion sequence binding;nucleoside phosphate binding;rRNA binding; 7;3;4;5;1;4;5;3;3;4;4;6;3;6;6;4;7;6;7;5;3;2;8;4;6; K11294 map05130; Pathogenic Escherichia coli infection; IPR034233;IPR034230;IPR034234;IPR034235;IPR003954;IPR000504; Nucleolin, RNA recognition motif 2;Nucleolin, RNA recognition motif 1;Nucleolin, RNA recognition motif 3;Nucleolin, RNA recognition motif 4;RNA recognition motif domain, eukaryote;RNA recognition motif domain; nucleus Hs13644124 1379.0 AJ [A] RNA processing and modification;[J] Translation, ribosomal structure and biogenesis; Q14999 Cullin-7 OS=Homo sapiens OX=9606 GN=CUL7 PE=1 SV=2 - [CUL7_HUMAN] 0.997 0.915 0.944 1.473 0.925 1.137 1.089617486 nan 1.592432432 nan 1.031693989 nan 1.229189189 nan GO:0010975;GO:0051603;GO:0048468;GO:0016358;GO:0072358;GO:0007165;GO:0044707;GO:0071840;GO:0031346;GO:0051716;GO:0006986;GO:0048864;GO:0000003;GO:0048869;GO:0010256;GO:0044419;GO:0045664;GO:0048513;GO:0048514;GO:0010720;GO:0048518;GO:0007088;GO:0003006;GO:0010976;GO:0010033;GO:0000910;GO:0044700;GO:0044702;GO:0030968;GO:0019538;GO:0030163;GO:0051783;GO:0016567;GO:0033554;GO:0022604;GO:0022603;GO:0000226;GO:0061640;GO:0031175;GO:0007067;GO:0050789;GO:0044267;GO:0007346;GO:0000904;GO:0000902;GO:0044260;GO:0001568;GO:0016043;GO:0031344;GO:0065007;GO:0007049;GO:0051130;GO:0050793;GO:0009888;GO:0050794;GO:0006950;GO:0048863;GO:0008150;GO:0008152;GO:0010770;GO:0044767;GO:0050896;GO:0043412;GO:0051962;GO:0051960;GO:0048814;GO:0007275;GO:0051240;GO:0072359;GO:0051239;GO:0033043;GO:0000280;GO:0030154;GO:0051128;GO:0044248;GO:0006511;GO:0023052;GO:0070887;GO:0042221;GO:0009653;GO:0044699;GO:0050767;GO:0032446;GO:0010564;GO:0000281;GO:0060284;GO:0050769;GO:0030030;GO:0045666;GO:0036211;GO:0006508;GO:0032502;GO:0032501;GO:0048608;GO:0001570;GO:0009987;GO:0010769;GO:0044764;GO:0045597;GO:0045595;GO:0044257;GO:0032989;GO:0001890;GO:0032990;GO:0050775;GO:0007030;GO:0050773;GO:0051094;GO:0043170;GO:0035967;GO:0035966;GO:0048731;GO:0034976;GO:0048762;GO:0001944;GO:0061458;GO:1903047;GO:0022402;GO:0034620;GO:0043632;GO:0051302;GO:0051301;GO:1900006;GO:0048813;GO:0071704;GO:0071310;GO:0048812;GO:0051704;GO:0014031;GO:0048666;GO:0048667;GO:0060485;GO:0000278;GO:0030182;GO:0019941;GO:1901575;GO:0006464;GO:0036498;GO:0022414;GO:0044265;GO:0044763;GO:0007154;GO:0022008;GO:0009056;GO:0009057;GO:0006996;GO:0044238;GO:0048699;GO:0007017;GO:0007010;GO:0048858;GO:0007399;GO:0051726;GO:0048856;GO:0044237;GO:0001837;GO:1902589;GO:2000026;GO:0048285;GO:0016032;GO:0044403;GO:0070647;GO:0048522; regulation of neuron projection development;proteolysis involved in cellular protein catabolic process;cell development;dendrite development;cardiovascular system development;signal transduction;single-multicellular organism process;cellular component organization or biogenesis;positive regulation of cell projection organization;cellular response to stimulus;response to unfolded protein;stem cell development;reproduction;cellular developmental process;endomembrane system organization;interspecies interaction between organisms;regulation of neuron differentiation;animal organ development;blood vessel morphogenesis;positive regulation of cell development;positive regulation of biological process;regulation of mitotic nuclear division;developmental process involved in reproduction;positive regulation of neuron projection development;response to organic substance;cytokinesis;single organism signaling;single organism reproductive process;endoplasmic reticulum unfolded protein response;protein metabolic process;protein catabolic process;regulation of nuclear division;protein ubiquitination;cellular response to stress;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;microtubule cytoskeleton organization;cytoskeleton-dependent cytokinesis;neuron projection development;mitotic nuclear division;regulation of biological process;cellular protein metabolic process;regulation of mitotic cell cycle;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;blood vessel development;cellular component organization;regulation of cell projection organization;biological regulation;cell cycle;positive regulation of cellular component organization;regulation of developmental process;tissue development;regulation of cellular process;response to stress;stem cell differentiation;biological_process;metabolic process;positive regulation of cell morphogenesis involved in differentiation;single-organism developmental process;response to stimulus;macromolecule modification;positive regulation of nervous system development;regulation of nervous system development;regulation of dendrite morphogenesis;multicellular organism development;positive regulation of multicellular organismal process;circulatory system development;regulation of multicellular organismal process;regulation of organelle organization;nuclear division;cell differentiation;regulation of cellular component organization;cellular catabolic process;ubiquitin-dependent protein catabolic process;signaling;cellular response to chemical stimulus;response to chemical;anatomical structure morphogenesis;single-organism process;regulation of neurogenesis;protein modification by small protein conjugation;regulation of cell cycle process;mitotic cytokinesis;regulation of cell development;positive regulation of neurogenesis;cell projection organization;positive regulation of neuron differentiation;protein modification process;proteolysis;developmental process;multicellular organismal process;reproductive structure development;vasculogenesis;cellular process;regulation of cell morphogenesis involved in differentiation;multi-organism cellular process;positive regulation of cell differentiation;regulation of cell differentiation;cellular protein catabolic process;cellular component morphogenesis;placenta development;cell part morphogenesis;positive regulation of dendrite morphogenesis;Golgi organization;regulation of dendrite development;positive regulation of developmental process;macromolecule metabolic process;cellular response to topologically incorrect protein;response to topologically incorrect protein;system development;response to endoplasmic reticulum stress;mesenchymal cell differentiation;vasculature development;reproductive system development;mitotic cell cycle process;cell cycle process;cellular response to unfolded protein;modification-dependent macromolecule catabolic process;regulation of cell division;cell division;positive regulation of dendrite development;dendrite morphogenesis;organic substance metabolic process;cellular response to organic substance;neuron projection morphogenesis;multi-organism process;mesenchymal cell development;neuron development;cell morphogenesis involved in neuron differentiation;mesenchyme development;mitotic cell cycle;neuron differentiation;modification-dependent protein catabolic process;organic substance catabolic process;cellular protein modification process;IRE1-mediated unfolded protein response;reproductive process;cellular macromolecule catabolic process;single-organism cellular process;cell communication;neurogenesis;catabolic process;macromolecule catabolic process;organelle organization;primary metabolic process;generation of neurons;microtubule-based process;cytoskeleton organization;cell projection morphogenesis;nervous system development;regulation of cell cycle;anatomical structure development;cellular metabolic process;epithelial to mesenchymal transition;single-organism organelle organization;regulation of multicellular organismal development;organelle fission;viral process;symbiosis, encompassing mutualism through parasitism;protein modification by small protein conjugation or removal;positive regulation of cellular process; 6;6;4;4;5;4;3;2;5;3;5;5;2;4;4;3;7;4;4;5;2;6;3;6;4;5;3;3;5;4;5;5;9;4;5;4;5;6;5;5;2;5;5;5;5;4;4;3;5;2;4;4;3;4;3;3;6;1;2;5;3;2;5;4;5;6;4;3;5;3;5;6;5;4;4;8;2;4;3;3;2;6;8;5;6;5;5;4;6;5;5;2;2;4;5;2;6;3;4;4;6;4;4;5;6;5;5;3;4;5;4;4;5;6;5;5;5;4;6;6;4;4;5;5;3;5;6;2;6;5;6;5;5;6;7;4;6;6;2;5;3;4;6;3;5;4;3;7;4;5;5;5;4;3;3;6;4;4;5;4;4;7;3; GO:0031974;GO:0043234;GO:0005815;GO:0031981;GO:0000152;GO:0005794;GO:1902494;GO:1990234;GO:0031461;GO:0031467;GO:0043231;GO:0043233;GO:0005829;GO:0000151;GO:0044428;GO:0044424;GO:0044422;GO:0043232;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0005856;GO:0005654;GO:0044430;GO:0048471;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0032991;GO:0044464;GO:0005623;GO:0005813;GO:0043226;GO:0015630;GO:1990393;GO:0005575;GO:0070013;GO:0005680; membrane-enclosed lumen;protein complex;microtubule organizing center;nuclear lumen;nuclear ubiquitin ligase complex;Golgi apparatus;catalytic complex;transferase complex;cullin-RING ubiquitin ligase complex;Cul7-RING ubiquitin ligase complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;ubiquitin ligase complex;nuclear part;intracellular part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;cytoskeleton;nucleoplasm;cytoskeletal part;perinuclear region of cytoplasm;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;macromolecular complex;cell part;cell;centrosome;organelle;microtubule cytoskeleton;3M complex;cellular_component;intracellular organelle lumen;anaphase-promoting complex; 2;3;5;5;5;4;4;5;5;6;4;3;5;4;4;3;2;4;3;3;3;3;5;5;4;5;3;3;4;4;5;2;2;2;5;2;6;4;1;4;6; K10613 map04120; Ubiquitin mediated proteolysis; IPR014722;IPR031223;IPR016024;IPR008979;IPR021097;IPR019559;IPR004939;IPR011991;IPR016158;IPR001373; Ribosomal protein L2 domain 2;Cullin-7;Armadillo-type fold;Galactose-binding domain-like;CPH domain;Cullin protein, neddylation domain;APC10/DOC domain;Winged helix-turn-helix DNA-binding domain;Cullin homology;Cullin, N-terminal; cytosol, nucleus P51815 Zinc finger protein 75D OS=Homo sapiens OX=9606 GN=ZNF75D PE=2 SV=2 - [ZN75D_HUMAN] 0.855 1.136 1.141 1.186 1.014 0.589 0.752640845 nan 1.169625247 nan 1.004401408 nan 0.58086785 nan GO:0032774;GO:0044237;GO:0006139;GO:0090304;GO:0044249;GO:0006807;GO:1901576;GO:0043170;GO:0097659;GO:1901362;GO:0071704;GO:0010467;GO:1901360;GO:0018130;GO:0009987;GO:0006725;GO:0044260;GO:0009058;GO:0034645;GO:0009059;GO:0008150;GO:0008152;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0034641;GO:0006351;GO:0019438; RNA biosynthetic process;cellular metabolic process;nucleobase-containing compound metabolic process;nucleic acid metabolic process;cellular biosynthetic process;nitrogen compound metabolic process;organic substance biosynthetic process;macromolecule metabolic process;nucleic acid-templated transcription;organic cyclic compound biosynthetic process;organic substance metabolic process;gene expression;organic cyclic compound metabolic process;heterocycle biosynthetic process;cellular process;cellular aromatic compound metabolic process;cellular macromolecule metabolic process;biosynthetic process;cellular macromolecule biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound metabolic process;transcription, DNA-templated;aromatic compound biosynthetic process; 6;3;4;5;4;3;4;4;7;5;3;5;4;5;2;4;4;3;5;5;1;2;5;4;5;3;5;4;6;5; GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;4;2;2;3;1;3; GO:1901363;GO:0003674;GO:0001071;GO:0003676;GO:0003677;GO:0043565;GO:0046914;GO:0008270;GO:0043167;GO:0046872;GO:0043169;GO:0003700;GO:0097159;GO:0005488; heterocyclic compound binding;molecular_function;nucleic acid binding transcription factor activity;nucleic acid binding;DNA binding;sequence-specific DNA binding;transition metal ion binding;zinc ion binding;ion binding;metal ion binding;cation binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;binding; 3;1;2;4;5;6;6;7;3;5;4;3;3;2; K09229 IPR013087;IPR008916;IPR003309;IPR001909; Zinc finger C2H2-type;Retrovirus capsid, C-terminal;SCAN domain;Krueppel-associated box; nucleus Hs19882197 608.0 R [R] General function prediction only; Q6P4F1 Alpha-(1,3)-fucosyltransferase 10 OS=Homo sapiens OX=9606 GN=FUT10 PE=2 SV=2 - [FUT10_HUMAN] 1.587 0.692 0.78 0.896 1.491 nan 2.293352601 nan 0.600938967 nan 1.12716763 nan nan nan GO:0008104;GO:0060322;GO:0044281;GO:0044282;GO:0044712;GO:0044710;GO:0000003;GO:0070727;GO:0009611;GO:0048513;GO:0033036;GO:0006605;GO:0045184;GO:0022029;GO:0051704;GO:0019827;GO:0044703;GO:0044702;GO:0044707;GO:0009790;GO:0019538;GO:0048870;GO:0016052;GO:0002376;GO:0021537;GO:0019320;GO:0006457;GO:0021885;GO:0009566;GO:0006928;GO:0051674;GO:0044267;GO:1901575;GO:0044260;GO:0006886;GO:0044699;GO:0016477;GO:0019317;GO:0006810;GO:0019318;GO:0042060;GO:0098727;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0030097;GO:0044723;GO:0051234;GO:0044724;GO:0097150;GO:0007420;GO:0046907;GO:0021543;GO:0050896;GO:0006950;GO:0043413;GO:0019953;GO:0044249;GO:0034645;GO:0007417;GO:0044765;GO:0021799;GO:0002520;GO:0021795;GO:0032502;GO:0032501;GO:0009987;GO:0021987;GO:1901137;GO:0005996;GO:1901135;GO:0043170;GO:0006004;GO:0048731;GO:0046365;GO:0009100;GO:0007275;GO:0006486;GO:0042354;GO:0042355;GO:0009101;GO:0071704;GO:0071702;GO:0048534;GO:1901576;GO:0034613;GO:0070085;GO:0006464;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051649;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0005975;GO:0007399;GO:0048856;GO:0044237;GO:0030900;GO:0015031;GO:1902582; protein localization;head development;small molecule metabolic process;small molecule catabolic process;single-organism catabolic process;single-organism metabolic process;reproduction;cellular macromolecule localization;response to wounding;animal organ development;macromolecule localization;protein targeting;establishment of protein localization;telencephalon cell migration;multi-organism process;stem cell population maintenance;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;embryo development;protein metabolic process;cell motility;carbohydrate catabolic process;immune system process;telencephalon development;hexose catabolic process;protein folding;forebrain cell migration;fertilization;movement of cell or subcellular component;localization of cell;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule metabolic process;intracellular protein transport;single-organism process;cell migration;fucose catabolic process;transport;hexose metabolic process;wound healing;maintenance of cell number;macromolecule modification;protein modification process;biological_process;metabolic process;hemopoiesis;single-organism carbohydrate metabolic process;establishment of localization;single-organism carbohydrate catabolic process;neuronal stem cell population maintenance;brain development;intracellular transport;pallium development;response to stimulus;response to stress;macromolecule glycosylation;sexual reproduction;cellular biosynthetic process;cellular macromolecule biosynthetic process;central nervous system development;single-organism transport;cerebral cortex radially oriented cell migration;immune system development;cerebral cortex cell migration;developmental process;multicellular organismal process;cellular process;cerebral cortex development;carbohydrate derivative biosynthetic process;monosaccharide metabolic process;carbohydrate derivative metabolic process;macromolecule metabolic process;fucose metabolic process;system development;monosaccharide catabolic process;glycoprotein metabolic process;multicellular organism development;protein glycosylation;L-fucose metabolic process;L-fucose catabolic process;glycoprotein biosynthetic process;organic substance metabolic process;organic substance transport;hematopoietic or lymphoid organ development;organic substance biosynthetic process;cellular protein localization;glycosylation;cellular protein modification process;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;catabolic process;localization;single-organism localization;cellular localization;locomotion;primary metabolic process;carbohydrate metabolic process;nervous system development;anatomical structure development;cellular metabolic process;forebrain development;protein transport;single-organism intracellular transport; 4;4;4;5;4;3;2;4;4;4;3;6;4;5;2;4;3;3;3;5;4;3;5;2;4;7;3;5;4;4;3;5;4;4;6;2;4;8;4;6;5;3;5;5;1;2;5;4;3;5;5;4;5;4;2;3;6;3;4;5;5;4;6;3;5;2;2;2;4;5;5;4;4;7;4;6;5;4;4;8;9;6;3;5;4;4;5;5;6;3;2;3;5;3;4;3;2;3;3;2;3;4;5;3;3;4;5;5; GO:0031984;GO:0016021;GO:0016020;GO:0005795;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0031985;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0031224;GO:0005737;GO:0031090;GO:0032580;GO:0044464;GO:0005623;GO:0005575;GO:0098791; organelle subcompartment;integral component of membrane;membrane;Golgi stack;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;Golgi cisterna;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intrinsic component of membrane;cytoplasm;organelle membrane;Golgi cisterna membrane;cell part;cell;cellular_component;Golgi subcompartment; 4;4;2;5;4;4;4;3;2;2;3;3;3;2;4;6;3;5;3;4;3;4;3;6;2;2;1;5; GO:0016740;GO:0016757;GO:0003674;GO:0008417;GO:0016758;GO:0046920;GO:0003824; transferase activity;transferase activity, transferring glycosyl groups;molecular_function;fucosyltransferase activity;transferase activity, transferring hexosyl groups;alpha-(1->3)-fucosyltransferase activity;catalytic activity; 3;4;1;6;5;7;2; K09669 IPR031481;IPR017176;IPR001503; Fucosyltransferase, N-terminal;Alpha-(1, 3)-fucosyltransferase, metazoan;Glycosyl transferase family 10; endoplasmic reticulum Hs19923648 894.0 GE [G] Carbohydrate transport and metabolism;[E] Amino acid transport and metabolism; Q969M7 NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1 - [UBE2F_HUMAN] 0.956 1.054 0.959 1.099 1.042 1.401 0.907020873 nan 1.054702495 nan 0.909867173 nan 1.34452975 nan GO:0044237;GO:0090304;GO:0034641;GO:0006807;GO:0000209;GO:0043170;GO:0044699;GO:0044267;GO:0051716;GO:0045116;GO:0044260;GO:0071704;GO:0006281;GO:0070647;GO:0032446;GO:1901360;GO:0070534;GO:0033554;GO:0006139;GO:0009987;GO:0006725;GO:0044710;GO:0006464;GO:0006974;GO:0006259;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0046483;GO:0044238;GO:0006301;GO:0019538;GO:0050896;GO:0006950;GO:0016567;GO:0044763; cellular metabolic process;nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;protein polyubiquitination;macromolecule metabolic process;single-organism process;cellular protein metabolic process;cellular response to stimulus;protein neddylation;cellular macromolecule metabolic process;organic substance metabolic process;DNA repair;protein modification by small protein conjugation or removal;protein modification by small protein conjugation;organic cyclic compound metabolic process;protein K63-linked ubiquitination;cellular response to stress;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;single-organism metabolic process;cellular protein modification process;cellular response to DNA damage stimulus;DNA metabolic process;macromolecule modification;protein modification process;biological_process;metabolic process;heterocycle metabolic process;primary metabolic process;postreplication repair;protein metabolic process;response to stimulus;response to stress;protein ubiquitination;single-organism cellular process; 3;5;4;3;10;4;2;5;3;9;4;3;4;7;8;4;11;4;4;2;4;3;6;5;5;5;5;1;2;4;3;5;4;2;3;9;3; GO:0043231;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0043229;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;intracellular organelle;cell part;cell;intracellular;cellular_component;intracellular part; 4;3;2;4;5;3;2;2;3;1;3; GO:0044389;GO:0035639;GO:1901363;GO:0019899;GO:0003674;GO:0005488;GO:0001883;GO:0097367;GO:0001882;GO:0043167;GO:0004842;GO:1901265;GO:0036094;GO:0019788;GO:0016740;GO:0032549;GO:0017076;GO:0061659;GO:0005524;GO:0019787;GO:0000166;GO:0061630;GO:0016874;GO:0032555;GO:0031625;GO:0003824;GO:0097159;GO:0030554;GO:0032550;GO:0032559;GO:0005515;GO:0043168;GO:0032553; ubiquitin-like protein ligase binding;purine ribonucleoside triphosphate binding;heterocyclic compound binding;enzyme binding;molecular_function;binding;purine nucleoside binding;carbohydrate derivative binding;nucleoside binding;ion binding;ubiquitin-protein transferase activity;nucleoside phosphate binding;small molecule binding;NEDD8 transferase activity;transferase activity;ribonucleoside binding;purine nucleotide binding;ubiquitin-like protein ligase activity;ATP binding;ubiquitin-like protein transferase activity;nucleotide binding;ubiquitin protein ligase activity;ligase activity;purine ribonucleotide binding;ubiquitin protein ligase binding;catalytic activity;organic cyclic compound binding;adenyl nucleotide binding;purine ribonucleoside binding;adenyl ribonucleotide binding;protein binding;anion binding;ribonucleotide binding; 5;5;3;4;1;2;5;3;4;3;5;4;3;5;3;5;5;5;6;4;4;6;3;5;6;2;3;6;6;6;3;4;4; K10687 map04120; Ubiquitin mediated proteolysis; IPR016135;IPR023313;IPR000608; Ubiquitin-conjugating enzyme/RWD-like;Ubiquitin-conjugating enzyme, active site;Ubiquitin-conjugating enzyme E2; cytosol Hs18087857 386.0 O [O] Posttranslational modification, protein turnover, chaperones; O15439 Multidrug resistance-associated protein 4 OS=Homo sapiens OX=9606 GN=ABCC4 PE=1 SV=3 - [MRP4_HUMAN] 0.69 0.799 0.8 0.871 0.729 5.663 0.863579474 nan 1.19478738 nan 1.001251564 nan 7.768175583 nan GO:0006887;GO:0007599;GO:0007596;GO:0006820;GO:0071840;GO:0044710;GO:0048869;GO:0009611;GO:0030168;GO:0033036;GO:0015718;GO:0015849;GO:0015711;GO:0010876;GO:0055114;GO:0016192;GO:0044707;GO:0048646;GO:0044782;GO:0022607;GO:0046717;GO:0000902;GO:1901571;GO:0032310;GO:0016043;GO:0045055;GO:0065007;GO:0065008;GO:0042384;GO:0015908;GO:0060271;GO:0006811;GO:0006810;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0051234;GO:0046903;GO:0050896;GO:0001775;GO:0032309;GO:0008152;GO:0006869;GO:0010927;GO:0009653;GO:0044699;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0055085;GO:0032990;GO:0032940;GO:0071715;GO:0030030;GO:0030031;GO:1902589;GO:0032989;GO:0071702;GO:0015732;GO:0044767;GO:0044765;GO:0044763;GO:0070925;GO:0051179;GO:1902578;GO:0046942;GO:0006996;GO:0048858;GO:0048856;GO:0044085;GO:0002576; exocytosis;hemostasis;blood coagulation;anion transport;cellular component organization or biogenesis;single-organism metabolic process;cellular developmental process;response to wounding;platelet activation;macromolecule localization;monocarboxylic acid transport;organic acid transport;organic anion transport;lipid localization;oxidation-reduction process;vesicle-mediated transport;single-multicellular organism process;anatomical structure formation involved in morphogenesis;cilium organization;cellular component assembly;acid secretion;cell morphogenesis;fatty acid derivative transport;prostaglandin secretion;cellular component organization;regulated exocytosis;biological regulation;regulation of biological quality;cilium assembly;fatty acid transport;cilium morphogenesis;ion transport;transport;wound healing;response to stress;coagulation;biological_process;establishment of localization;secretion;response to stimulus;cell activation;icosanoid secretion;metabolic process;lipid transport;cellular component assembly involved in morphogenesis;anatomical structure morphogenesis;single-organism process;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;transmembrane transport;cell part morphogenesis;secretion by cell;icosanoid transport;cell projection organization;cell projection assembly;single-organism organelle organization;cellular component morphogenesis;organic substance transport;prostaglandin transport;single-organism developmental process;single-organism transport;single-organism cellular process;organelle assembly;localization;single-organism localization;carboxylic acid transport;organelle organization;cell projection morphogenesis;anatomical structure development;cellular component biogenesis;platelet degranulation; 5;5;5;6;2;3;4;4;5;3;7;5;6;4;4;5;3;3;5;4;6;5;5;8;3;6;2;3;5;6;6;5;4;5;3;4;1;3;5;2;4;7;2;5;4;3;2;2;2;4;2;4;5;4;6;4;5;4;4;5;7;3;4;3;5;2;3;6;4;5;3;3;7; GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0099503;GO:0098588;GO:0098589;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0031224;GO:0042827;GO:0030141;GO:0097708;GO:0012506;GO:0031088;GO:0044446;GO:0044444;GO:0012505;GO:0005737;GO:0030667;GO:0031090;GO:0031410;GO:0044459;GO:0016323;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098805;GO:0005886;GO:0005575; vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;secretory vesicle;bounding membrane of organelle;membrane region;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;plasma membrane region;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;intrinsic component of membrane;platelet dense granule;secretory granule;intracellular vesicle;vesicle membrane;platelet dense granule membrane;intracellular organelle part;cytoplasmic part;endomembrane system;cytoplasm;secretory granule membrane;organelle membrane;cytoplasmic vesicle;plasma membrane part;basolateral plasma membrane;cytoplasmic vesicle membrane;cell part;cell;intracellular;cell periphery;whole membrane;plasma membrane;cellular_component; 4;5;4;2;5;6;4;3;4;3;2;2;4;3;3;2;4;3;5;4;4;4;5;3;4;3;4;4;3;5;3;4;5;2;2;3;3;3;3;1; GO:1901363;GO:0016818;GO:0016614;GO:0097367;GO:0016817;GO:0015405;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042626;GO:0042623;GO:0015399;GO:0032549;GO:0017076;GO:0022804;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0005524;GO:0016491;GO:0016820;GO:0043167;GO:0005215;GO:0030554;GO:0000166;GO:0016404;GO:0016616;GO:0043492;GO:0001883;GO:0001882;GO:0017111;GO:0043168;GO:0022857; heterocyclic compound binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;oxidoreductase activity, acting on CH-OH group of donors;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;P-P-bond-hydrolysis-driven transmembrane transporter activity;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase activity, coupled to transmembrane movement of substances;ATPase activity, coupled;primary active transmembrane transporter activity;ribonucleoside binding;purine nucleotide binding;active transmembrane transporter activity;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ATP binding;oxidoreductase activity;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ion binding;transporter activity;adenyl nucleotide binding;nucleotide binding;15-hydroxyprostaglandin dehydrogenase (NAD+) activity;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;ATPase activity, coupled to movement of substances;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;anion binding;transmembrane transporter activity; 3;5;4;3;4;6;1;2;8;4;6;9;5;5;5;4;3;2;3;3;6;6;5;6;4;5;6;3;5;3;2;6;4;6;5;10;5;4;7;4;3; K05673 map02010;map04024;map04976; ABC transporters;cAMP signaling pathway;Bile secretion; IPR017871;IPR030240;IPR003593;IPR003439;IPR011527;IPR027417; ABC transporter, conserved site;Multidrug resistance-associated protein 4;AAA+ ATPase domain;ABC transporter-like;ABC transporter type 1, transmembrane domain;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Hs5031915 2732.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; Q8WXW3 Progesterone-induced-blocking factor 1 OS=Homo sapiens OX=9606 GN=PIBF1 PE=1 SV=2 - [PIBF1_HUMAN] 0.914 1.315 0.695 0.988 1.392 0.848 0.695057034 0.00246098 0.709770115 0.007493971 0.52851711 0.000970791 0.609195402 0.10189748 GO:0019216;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0032147;GO:0043933;GO:0007165;GO:0044283;GO:1901576;GO:0051656;GO:0044707;GO:0071840;GO:0006636;GO:0065003;GO:0051716;GO:0044711;GO:0010605;GO:0010604;GO:0009968;GO:0070727;GO:0009966;GO:0009967;GO:0048858;GO:0018212;GO:0042531;GO:0042532;GO:0007080;GO:0044093;GO:0016310;GO:0048518;GO:0048519;GO:0030101;GO:0033036;GO:0002683;GO:0010565;GO:0051055;GO:0032655;GO:0032653;GO:0060255;GO:0045859;GO:0042327;GO:0032787;GO:0001516;GO:0050865;GO:0046649;GO:0043436;GO:0042526;GO:0042325;GO:0044700;GO:0042521;GO:0042326;GO:0044249;GO:0019538;GO:0050730;GO:0050732;GO:0016053;GO:0002376;GO:0050731;GO:0010531;GO:0035058;GO:0044782;GO:0010648;GO:0032989;GO:0022607;GO:0009892;GO:0009893;GO:0009890;GO:0033674;GO:0045321;GO:0072698;GO:0007067;GO:0050789;GO:0046427;GO:0044267;GO:0009653;GO:0051347;GO:0000902;GO:0044260;GO:1901570;GO:0046425;GO:0050866;GO:0016043;GO:0051225;GO:0065007;GO:0007049;GO:0065009;GO:0044281;GO:0002695;GO:0048646;GO:0043085;GO:0032814;GO:0006629;GO:0060271;GO:0050790;GO:0009889;GO:0044710;GO:0050794;GO:0033365;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:2001279;GO:1902532;GO:0007059;GO:1902533;GO:1902531;GO:0042180;GO:0044767;GO:0033559;GO:0007051;GO:0046394;GO:0006693;GO:0031400;GO:0071539;GO:0051249;GO:0007052;GO:0051338;GO:0006690;GO:0006692;GO:0045717;GO:0032733;GO:0048869;GO:0031327;GO:0001819;GO:0010562;GO:0044085;GO:0006633;GO:0006631;GO:0051241;GO:0042976;GO:0051239;GO:0051240;GO:0070271;GO:0001775;GO:0000280;GO:0031326;GO:0010927;GO:0023057;GO:0023052;GO:0018193;GO:0042384;GO:0023051;GO:0010647;GO:0010646;GO:0032815;GO:0044699;GO:0051248;GO:0051234;GO:0010563;GO:0051246;GO:0051247;GO:0007259;GO:0043549;GO:0045833;GO:0032270;GO:0051640;GO:0031399;GO:1902850;GO:0051641;GO:0031392;GO:0031393;GO:0032502;GO:0042509;GO:0032501;GO:0023056;GO:0032613;GO:0009987;GO:0032615;GO:0009058;GO:0007017;GO:0018108;GO:0042304;GO:0008610;GO:0051310;GO:1901568;GO:0044255;GO:0001932;GO:0032990;GO:0006461;GO:0032269;GO:0032268;GO:0000819;GO:0006082;GO:0051250;GO:0098813;GO:0043170;GO:0001816;GO:0001817;GO:1904893;GO:1904892;GO:0045860;GO:0050896;GO:0001818;GO:1904894;GO:0045922;GO:0002682;GO:0031401;GO:0030030;GO:0030031;GO:0031325;GO:0031324;GO:0031323;GO:0044380;GO:1903047;GO:0090307;GO:0022402;GO:0046890;GO:0051303;GO:0035556;GO:0046457;GO:0042519;GO:0071822;GO:0002694;GO:0006796;GO:0071704;GO:0042525;GO:0097696;GO:0032695;GO:0019217;GO:0006468;GO:0046426;GO:0000278;GO:0045937;GO:0045936;GO:0034613;GO:0006464;GO:0051174;GO:0000226;GO:0044763;GO:0051649;GO:0007154;GO:0070925;GO:0051179;GO:1902578;GO:0007260;GO:0006996;GO:0044238;GO:0000070;GO:0007010;GO:0051276;GO:0019752;GO:0048856;GO:0042505;GO:0042504;GO:0044237;GO:0046456;GO:1902589;GO:0050000;GO:0048285;GO:0006793;GO:0072330;GO:0001933;GO:1902580;GO:0001934;GO:0048523;GO:0048522; regulation of lipid metabolic process;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;macromolecular complex subunit organization;signal transduction;small molecule biosynthetic process;organic substance biosynthetic process;establishment of organelle localization;single-multicellular organism process;cellular component organization or biogenesis;unsaturated fatty acid biosynthetic process;macromolecular complex assembly;cellular response to stimulus;single-organism biosynthetic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;cellular macromolecule localization;regulation of signal transduction;positive regulation of signal transduction;cell projection morphogenesis;peptidyl-tyrosine modification;positive regulation of tyrosine phosphorylation of STAT protein;negative regulation of tyrosine phosphorylation of STAT protein;mitotic metaphase plate congression;positive regulation of molecular function;phosphorylation;positive regulation of biological process;negative regulation of biological process;natural killer cell activation;macromolecule localization;negative regulation of immune system process;regulation of cellular ketone metabolic process;negative regulation of lipid biosynthetic process;regulation of interleukin-12 production;regulation of interleukin-10 production;regulation of macromolecule metabolic process;regulation of protein kinase activity;positive regulation of phosphorylation;monocarboxylic acid metabolic process;prostaglandin biosynthetic process;regulation of cell activation;lymphocyte activation;oxoacid metabolic process;positive regulation of tyrosine phosphorylation of Stat6 protein;regulation of phosphorylation;single organism signaling;negative regulation of tyrosine phosphorylation of Stat4 protein;negative regulation of phosphorylation;cellular biosynthetic process;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;negative regulation of peptidyl-tyrosine phosphorylation;organic acid biosynthetic process;immune system process;positive regulation of peptidyl-tyrosine phosphorylation;activation of JAK1 kinase activity;nonmotile primary cilium assembly;cilium organization;negative regulation of cell communication;cellular component morphogenesis;cellular component assembly;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of kinase activity;leukocyte activation;protein localization to microtubule cytoskeleton;mitotic nuclear division;regulation of biological process;positive regulation of JAK-STAT cascade;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cell morphogenesis;cellular macromolecule metabolic process;fatty acid derivative biosynthetic process;regulation of JAK-STAT cascade;negative regulation of cell activation;cellular component organization;spindle assembly;biological regulation;cell cycle;regulation of molecular function;small molecule metabolic process;negative regulation of leukocyte activation;anatomical structure formation involved in morphogenesis;positive regulation of catalytic activity;regulation of natural killer cell activation;lipid metabolic process;cilium morphogenesis;regulation of catalytic activity;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;protein localization to organelle;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of unsaturated fatty acid biosynthetic process;negative regulation of intracellular signal transduction;chromosome segregation;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;cellular ketone metabolic process;single-organism developmental process;unsaturated fatty acid metabolic process;spindle organization;carboxylic acid biosynthetic process;prostaglandin metabolic process;negative regulation of protein modification process;protein localization to centrosome;regulation of lymphocyte activation;mitotic spindle organization;regulation of transferase activity;icosanoid metabolic process;prostanoid metabolic process;negative regulation of fatty acid biosynthetic process;positive regulation of interleukin-10 production;cellular developmental process;negative regulation of cellular biosynthetic process;positive regulation of cytokine production;positive regulation of phosphorus metabolic process;cellular component biogenesis;fatty acid biosynthetic process;fatty acid metabolic process;negative regulation of multicellular organismal process;activation of Janus kinase activity;regulation of multicellular organismal process;positive regulation of multicellular organismal process;protein complex biogenesis;cell activation;nuclear division;regulation of cellular biosynthetic process;cellular component assembly involved in morphogenesis;negative regulation of signaling;signaling;peptidyl-amino acid modification;cilium assembly;regulation of signaling;positive regulation of cell communication;regulation of cell communication;negative regulation of natural killer cell activation;single-organism process;negative regulation of protein metabolic process;establishment of localization;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;JAK-STAT cascade;regulation of kinase activity;negative regulation of lipid metabolic process;positive regulation of cellular protein metabolic process;organelle localization;regulation of protein modification process;microtubule cytoskeleton organization involved in mitosis;cellular localization;regulation of prostaglandin biosynthetic process;negative regulation of prostaglandin biosynthetic process;developmental process;regulation of tyrosine phosphorylation of STAT protein;multicellular organismal process;positive regulation of signaling;interleukin-10 production;cellular process;interleukin-12 production;biosynthetic process;microtubule-based process;peptidyl-tyrosine phosphorylation;regulation of fatty acid biosynthetic process;lipid biosynthetic process;metaphase plate congression;fatty acid derivative metabolic process;cellular lipid metabolic process;regulation of protein phosphorylation;cell part morphogenesis;protein complex assembly;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;sister chromatid segregation;organic acid metabolic process;negative regulation of lymphocyte activation;nuclear chromosome segregation;macromolecule metabolic process;cytokine production;regulation of cytokine production;negative regulation of STAT cascade;regulation of STAT cascade;positive regulation of protein kinase activity;response to stimulus;negative regulation of cytokine production;positive regulation of STAT cascade;negative regulation of fatty acid metabolic process;regulation of immune system process;positive regulation of protein modification process;cell projection organization;cell projection assembly;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;protein localization to cytoskeleton;mitotic cell cycle process;mitotic spindle assembly;cell cycle process;regulation of lipid biosynthetic process;establishment of chromosome localization;intracellular signal transduction;prostanoid biosynthetic process;regulation of tyrosine phosphorylation of Stat4 protein;protein complex subunit organization;regulation of leukocyte activation;phosphate-containing compound metabolic process;organic substance metabolic process;regulation of tyrosine phosphorylation of Stat6 protein;STAT cascade;negative regulation of interleukin-12 production;regulation of fatty acid metabolic process;protein phosphorylation;negative regulation of JAK-STAT cascade;mitotic cell cycle;positive regulation of phosphate metabolic process;negative regulation of phosphate metabolic process;cellular protein localization;cellular protein modification process;regulation of phosphorus metabolic process;microtubule cytoskeleton organization;single-organism cellular process;establishment of localization in cell;cell communication;organelle assembly;localization;single-organism localization;tyrosine phosphorylation of STAT protein;organelle organization;primary metabolic process;mitotic sister chromatid segregation;cytoskeleton organization;chromosome organization;carboxylic acid metabolic process;anatomical structure development;tyrosine phosphorylation of Stat6 protein;tyrosine phosphorylation of Stat4 protein;cellular metabolic process;icosanoid biosynthetic process;single-organism organelle organization;chromosome localization;organelle fission;phosphorus metabolic process;monocarboxylic acid biosynthetic process;negative regulation of protein phosphorylation;single-organism cellular localization;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 5;4;6;4;3;3;3;3;9;4;4;5;4;4;3;2;7;5;3;4;4;4;4;4;4;4;5;8;8;8;5;4;6;2;2;5;3;3;5;5;5;5;4;7;7;7;8;4;4;5;9;7;3;9;7;4;4;8;8;5;2;8;9;6;5;4;4;4;3;3;4;7;3;8;5;2;7;5;3;6;5;4;5;7;4;3;6;2;4;3;4;4;3;5;6;4;6;4;4;3;3;6;5;5;1;2;7;5;4;5;5;4;3;6;5;6;7;6;9;5;6;5;5;6;6;5;4;5;4;5;3;6;5;3;8;3;3;4;4;6;5;4;3;2;7;5;3;4;4;6;2;5;3;5;5;5;7;6;4;5;4;6;6;3;8;7;2;8;2;3;5;2;5;3;4;8;6;5;6;4;4;7;5;5;5;5;5;4;5;5;4;4;4;6;6;8;2;4;6;5;3;6;4;5;4;4;4;7;5;6;4;5;5;5;7;9;5;4;5;3;9;6;5;6;7;7;5;6;6;5;6;5;5;3;4;4;5;2;3;8;4;3;6;5;5;6;3;9;9;3;6;4;5;5;4;7;7;4;7;3;3; GO:0043231;GO:0043232;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0015630;GO:0005622;GO:0043227;GO:0005856;GO:0044430;GO:0044446;GO:0044444;GO:0043226;GO:0005737;GO:0005634;GO:0044450;GO:0044464;GO:0005623;GO:0043228;GO:0005615;GO:0005813;GO:0005815;GO:0005576;GO:0034451;GO:0005575; intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;intracellular part;extracellular region part;organelle part;intracellular organelle;microtubule cytoskeleton;intracellular;membrane-bounded organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;cytoplasmic part;organelle;cytoplasm;nucleus;microtubule organizing center part;cell part;cell;non-membrane-bounded organelle;extracellular space;centrosome;microtubule organizing center;extracellular region;centriolar satellite;cellular_component; 4;4;3;2;2;3;6;3;3;5;4;3;4;2;4;5;5;2;2;3;3;5;5;2;6;1; GO:0005126;GO:0003674;GO:0005136;GO:0005488;GO:0005515;GO:0005102;GO:0070851; cytokine receptor binding;molecular_function;interleukin-4 receptor binding;binding;protein binding;receptor binding;growth factor receptor binding; 5;1;6;2;3;4;5; K16538 IPR026205; Progesterone-induced-blocking factor 1; nucleus P02787 Serotransferrin OS=Homo sapiens OX=9606 GN=TF PE=1 SV=3 - [TRFE_HUMAN] 1.165 0.973 0.824 1.165 1.011 0.9 1.197327852 nan 1.152324431 7.35E-255 0.846865365 1.42E-44 0.890207715 3.36E-72 GO:0008104;GO:0007599;GO:0060249;GO:0051049;GO:0007596;GO:0055072;GO:0006826;GO:0055076;GO:0098771;GO:0048260;GO:0055082;GO:0071840;GO:0051716;GO:0001895;GO:0009611;GO:0048518;GO:0050801;GO:0019725;GO:0051050;GO:0045184;GO:0071281;GO:0010038;GO:0070838;GO:0030168;GO:0016192;GO:0044707;GO:0048878;GO:0050789;GO:0010039;GO:0046916;GO:0070627;GO:0006887;GO:0016043;GO:0045055;GO:0065007;GO:0006812;GO:0065008;GO:0051130;GO:0015684;GO:0006811;GO:0006810;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0032940;GO:0048259;GO:0051234;GO:0046903;GO:0006897;GO:0050896;GO:0006898;GO:0071248;GO:0001775;GO:0055065;GO:0071241;GO:0051128;GO:0070887;GO:0044699;GO:0000041;GO:0032501;GO:0006879;GO:0050878;GO:0006875;GO:0009987;GO:0006873;GO:0060627;GO:0030001;GO:0030003;GO:0099587;GO:0055080;GO:0001894;GO:0032879;GO:0055085;GO:0042592;GO:0033036;GO:0072511;GO:0072512;GO:0048871;GO:0015682;GO:0010035;GO:0031647;GO:1990267;GO:0097459;GO:0071702;GO:0097286;GO:0033572;GO:0044765;GO:0044763;GO:0042221;GO:0030100;GO:0051179;GO:1902578;GO:0097460;GO:0098659;GO:0015031;GO:0098657;GO:0045807;GO:0002576;GO:0048522; protein localization;hemostasis;anatomical structure homeostasis;regulation of transport;blood coagulation;iron ion homeostasis;iron ion transport;transition metal ion homeostasis;inorganic ion homeostasis;positive regulation of receptor-mediated endocytosis;cellular chemical homeostasis;cellular component organization or biogenesis;cellular response to stimulus;retina homeostasis;response to wounding;positive regulation of biological process;ion homeostasis;cellular homeostasis;positive regulation of transport;establishment of protein localization;cellular response to iron ion;response to metal ion;divalent metal ion transport;platelet activation;vesicle-mediated transport;single-multicellular organism process;chemical homeostasis;regulation of biological process;response to iron ion;cellular transition metal ion homeostasis;ferrous iron import;exocytosis;cellular component organization;regulated exocytosis;biological regulation;cation transport;regulation of biological quality;positive regulation of cellular component organization;ferrous iron transport;ion transport;transport;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;secretion by cell;regulation of receptor-mediated endocytosis;establishment of localization;secretion;endocytosis;response to stimulus;receptor-mediated endocytosis;cellular response to metal ion;cell activation;metal ion homeostasis;cellular response to inorganic substance;regulation of cellular component organization;cellular response to chemical stimulus;single-organism process;transition metal ion transport;multicellular organismal process;cellular iron ion homeostasis;regulation of body fluid levels;cellular metal ion homeostasis;cellular process;cellular ion homeostasis;regulation of vesicle-mediated transport;metal ion transport;cellular cation homeostasis;inorganic ion import into cell;cation homeostasis;tissue homeostasis;regulation of localization;transmembrane transport;homeostatic process;macromolecule localization;divalent inorganic cation transport;trivalent inorganic cation transport;multicellular organismal homeostasis;ferric iron transport;response to inorganic substance;regulation of protein stability;response to transition metal nanoparticle;iron ion import into cell;organic substance transport;iron ion import;transferrin transport;single-organism transport;single-organism cellular process;response to chemical;regulation of endocytosis;localization;single-organism localization;ferrous iron import into cell;inorganic cation import into cell;protein transport;import into cell;positive regulation of endocytosis;platelet degranulation;positive regulation of cellular process; 4;5;5;4;5;10;9;9;7;5;5;2;3;6;4;2;6;4;3;4;6;5;8;5;5;3;5;2;5;9;10;5;3;6;2;6;3;4;9;5;4;5;3;3;4;1;4;6;3;5;6;2;7;6;4;8;5;4;4;2;8;2;10;4;8;2;6;4;7;7;6;7;5;3;4;4;3;7;7;4;8;4;4;4;8;5;10;6;4;3;3;5;2;3;9;7;5;5;4;7;3; GO:0031974;GO:0072562;GO:0031983;GO:0031982;GO:0005773;GO:0016020;GO:0031988;GO:0044437;GO:0099503;GO:0098588;GO:0098589;GO:0034774;GO:0019898;GO:0043231;GO:0043234;GO:0043235;GO:0043230;GO:0043233;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0098590;GO:0043229;GO:0043227;GO:0044433;GO:0048471;GO:0030141;GO:0012505;GO:0031232;GO:0044446;GO:0016023;GO:0044444;GO:0044440;GO:0097708;GO:0019897;GO:0005770;GO:0009897;GO:0055037;GO:0005905;GO:0060205;GO:0005774;GO:0010008;GO:0005737;GO:0045177;GO:1903561;GO:0031090;GO:0031410;GO:0045178;GO:0009925;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0005622;GO:0098552;GO:0030139;GO:0071944;GO:1990712;GO:0005575;GO:0005615;GO:0098805;GO:0098802;GO:0043226;GO:0016324;GO:0005886;GO:0016323;GO:0070062;GO:0032991;GO:0005769;GO:0098797;GO:0098796;GO:0005576;GO:0005768; membrane-enclosed lumen;blood microparticle;vesicle lumen;vesicle;vacuole;membrane;membrane-bounded vesicle;vacuolar part;secretory vesicle;bounding membrane of organelle;membrane region;secretory granule lumen;extrinsic component of membrane;intracellular membrane-bounded organelle;protein complex;receptor complex;extracellular organelle;organelle lumen;intracellular part;membrane part;extracellular region part;organelle part;plasma membrane region;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;perinuclear region of cytoplasm;secretory granule;endomembrane system;extrinsic component of external side of plasma membrane;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;endosomal part;intracellular vesicle;extrinsic component of plasma membrane;late endosome;external side of plasma membrane;recycling endosome;coated pit;cytoplasmic membrane-bounded vesicle lumen;vacuolar membrane;endosome membrane;cytoplasm;apical part of cell;extracellular vesicle;organelle membrane;cytoplasmic vesicle;basal part of cell;basal plasma membrane;plasma membrane part;cell surface;cell part;cell;intracellular;side of membrane;endocytic vesicle;cell periphery;HFE-transferrin receptor complex;cellular_component;extracellular space;whole membrane;plasma membrane receptor complex;organelle;apical plasma membrane;plasma membrane;basolateral plasma membrane;extracellular exosome;macromolecular complex;early endosome;plasma membrane protein complex;membrane protein complex;extracellular region;endosome; 2;3;4;4;5;2;5;4;6;4;3;5;3;4;3;4;3;3;3;2;2;2;4;3;3;4;5;4;3;5;3;5;4;5;4;4;5;4;5;3;5;4;5;4;3;3;3;5;3;4;3;3;2;2;3;3;6;3;4;1;3;3;4;2;4;3;4;4;2;5;4;3;2;4; GO:0046873;GO:0046872;GO:0015091;GO:0005381;GO:1990459;GO:0003674;GO:0005488;GO:0046914;GO:0046915;GO:0022891;GO:0022890;GO:0022892;GO:0015075;GO:0043169;GO:0043167;GO:0005506;GO:0005215;GO:0072510;GO:0005515;GO:0005102;GO:0008324;GO:0008198;GO:0008199;GO:0022857; metal ion transmembrane transporter activity;metal ion binding;ferric iron transmembrane transporter activity;iron ion transmembrane transporter activity;transferrin receptor binding;molecular_function;binding;transition metal ion binding;transition metal ion transmembrane transporter activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;cation binding;ion binding;iron ion binding;transporter activity;trivalent inorganic cation transmembrane transporter activity;protein binding;receptor binding;cation transmembrane transporter activity;ferrous iron binding;ferric iron binding;transmembrane transporter activity; 8;5;9;10;5;1;2;6;9;4;7;3;5;4;3;7;2;8;3;4;6;8;8;3; K14736 map04066;map04978; HIF-1 signaling pathway;Mineral absorption; IPR030685;IPR016357;IPR018195;IPR001156; Serotransferrin, mammalian;Transferrin;Transferrin family, iron binding site;Transferrin-like domain; extracellular Hs4557871 1449.0 P [P] Inorganic ion transport and metabolism; P02786 Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2 - [TFR1_HUMAN] 0.983 0.742 1.559 1.05 0.837 0.654 1.324797844 0.062065792 1.254480287 0.009848208 2.101078167 0.002137482 0.781362007 0.793835267 GO:0008104;GO:0060249;GO:0055082;GO:0032846;GO:0032844;GO:0055072;GO:0006826;GO:0055076;GO:0098771;GO:0010042;GO:0002573;GO:0044707;GO:0051716;GO:0048869;GO:0048513;GO:0048518;GO:0065007;GO:0050801;GO:0019725;GO:0030154;GO:0048771;GO:0045184;GO:0010038;GO:0010039;GO:0010035;GO:0010033;GO:0048871;GO:0031667;GO:0048878;GO:0002376;GO:0046849;GO:0050789;GO:0009605;GO:0033572;GO:0046916;GO:0046852;GO:0046850;GO:0065008;GO:0006811;GO:0006810;GO:0006812;GO:0030099;GO:0045780;GO:0006952;GO:0006953;GO:0006950;GO:0008150;GO:0051239;GO:0030097;GO:0002526;GO:0051234;GO:0002521;GO:0002520;GO:0036293;GO:0050896;GO:0006954;GO:0055065;GO:0070887;GO:0001666;GO:0044699;GO:0051240;GO:0000041;GO:0055085;GO:0032502;GO:0032501;GO:0006879;GO:0006875;GO:0009987;GO:0006873;GO:0030001;GO:0001101;GO:0030003;GO:0055080;GO:0001894;GO:0045453;GO:0033036;GO:0007568;GO:0072512;GO:0042493;GO:0015682;GO:0035690;GO:0048731;GO:0009991;GO:1990267;GO:0042592;GO:0030316;GO:0007275;GO:0033993;GO:0046688;GO:0071702;GO:0048534;GO:0097286;GO:0032526;GO:0034103;GO:0034105;GO:0007584;GO:0044767;GO:0044765;GO:0044763;GO:0042221;GO:0051179;GO:1902578;GO:0070482;GO:1901700;GO:0009628;GO:0048856;GO:0045124;GO:0015031; protein localization;anatomical structure homeostasis;cellular chemical homeostasis;positive regulation of homeostatic process;regulation of homeostatic process;iron ion homeostasis;iron ion transport;transition metal ion homeostasis;inorganic ion homeostasis;response to manganese ion;myeloid leukocyte differentiation;single-multicellular organism process;cellular response to stimulus;cellular developmental process;animal organ development;positive regulation of biological process;biological regulation;ion homeostasis;cellular homeostasis;cell differentiation;tissue remodeling;establishment of protein localization;response to metal ion;response to iron ion;response to inorganic substance;response to organic substance;multicellular organismal homeostasis;response to nutrient levels;chemical homeostasis;immune system process;bone remodeling;regulation of biological process;response to external stimulus;transferrin transport;cellular transition metal ion homeostasis;positive regulation of bone remodeling;regulation of bone remodeling;regulation of biological quality;ion transport;transport;cation transport;myeloid cell differentiation;positive regulation of bone resorption;defense response;acute-phase response;response to stress;biological_process;regulation of multicellular organismal process;hemopoiesis;acute inflammatory response;establishment of localization;leukocyte differentiation;immune system development;response to decreased oxygen levels;response to stimulus;inflammatory response;metal ion homeostasis;cellular response to chemical stimulus;response to hypoxia;single-organism process;positive regulation of multicellular organismal process;transition metal ion transport;transmembrane transport;developmental process;multicellular organismal process;cellular iron ion homeostasis;cellular metal ion homeostasis;cellular process;cellular ion homeostasis;metal ion transport;response to acid chemical;cellular cation homeostasis;cation homeostasis;tissue homeostasis;bone resorption;macromolecule localization;aging;trivalent inorganic cation transport;response to drug;ferric iron transport;cellular response to drug;system development;response to extracellular stimulus;response to transition metal nanoparticle;homeostatic process;osteoclast differentiation;multicellular organism development;response to lipid;response to copper ion;organic substance transport;hematopoietic or lymphoid organ development;iron ion import;response to retinoic acid;regulation of tissue remodeling;positive regulation of tissue remodeling;response to nutrient;single-organism developmental process;single-organism transport;single-organism cellular process;response to chemical;localization;single-organism localization;response to oxygen levels;response to oxygen-containing compound;response to abiotic stimulus;anatomical structure development;regulation of bone resorption;protein transport; 4;5;5;3;3;10;9;9;7;5;7;3;3;4;4;2;2;6;4;5;4;4;5;5;4;4;4;5;5;2;5;2;3;6;9;5;5;3;5;4;6;6;4;4;7;3;1;3;5;6;3;6;3;5;2;5;8;4;4;2;3;8;4;2;2;10;8;2;6;7;4;7;7;5;6;3;4;7;4;8;5;4;4;4;4;8;4;5;5;5;4;10;5;4;4;4;3;4;3;3;2;3;4;4;3;3;4;5; GO:0031982;GO:0005773;GO:0016021;GO:0016020;GO:0005774;GO:0048770;GO:0098588;GO:0098589;GO:0043234;GO:0043235;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0044464;GO:0043229;GO:0043227;GO:0072562;GO:0044437;GO:0031224;GO:0048471;GO:0012505;GO:0044446;GO:0016023;GO:0044444;GO:0044440;GO:0031988;GO:0097708;GO:0055038;GO:0098590;GO:0055037;GO:0005905;GO:0031226;GO:0010008;GO:0005737;GO:0031090;GO:0031410;GO:0005739;GO:0044459;GO:0042470;GO:0009986;GO:0016323;GO:0070062;GO:0005623;GO:0005622;GO:1990712;GO:0071944;GO:0098552;GO:0005575;GO:0005615;GO:0098805;GO:0098802;GO:0043226;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0098797;GO:0098796;GO:0005576;GO:0005768; vesicle;vacuole;integral component of membrane;membrane;vacuolar membrane;pigment granule;bounding membrane of organelle;membrane region;protein complex;receptor complex;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;cell part;intracellular organelle;membrane-bounded organelle;blood microparticle;vacuolar part;intrinsic component of membrane;perinuclear region of cytoplasm;endomembrane system;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;endosomal part;membrane-bounded vesicle;intracellular vesicle;recycling endosome membrane;plasma membrane region;recycling endosome;coated pit;intrinsic component of plasma membrane;endosome membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;mitochondrion;plasma membrane part;melanosome;cell surface;basolateral plasma membrane;extracellular exosome;cell;intracellular;HFE-transferrin receptor complex;cell periphery;side of membrane;cellular_component;extracellular space;whole membrane;plasma membrane receptor complex;organelle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;plasma membrane protein complex;membrane protein complex;extracellular region;endosome; 4;5;4;2;4;6;4;3;3;4;3;4;3;2;2;2;4;2;3;3;3;4;3;5;3;3;5;4;5;5;4;6;4;5;3;4;5;4;3;5;5;3;7;3;4;4;2;3;4;3;3;1;3;3;4;2;4;3;3;2;4;3;2;4; GO:0060089;GO:0015399;GO:0046873;GO:0003725;GO:0008324;GO:0097367;GO:0001618;GO:0005381;GO:0003674;GO:0005488;GO:0003676;GO:0008320;GO:0022884;GO:0046915;GO:1901363;GO:0022804;GO:0001948;GO:0015450;GO:0022891;GO:0022890;GO:0022892;GO:0015075;GO:0015405;GO:0033570;GO:0046983;GO:0004998;GO:0042802;GO:0042803;GO:0005215;GO:0072510;GO:0003723;GO:0005515;GO:0097159;GO:0038024;GO:0004872;GO:0044822;GO:0008565;GO:0015091;GO:0022857; molecular transducer activity;primary active transmembrane transporter activity;metal ion transmembrane transporter activity;double-stranded RNA binding;cation transmembrane transporter activity;carbohydrate derivative binding;virus receptor activity;iron ion transmembrane transporter activity;molecular_function;binding;nucleic acid binding;protein transmembrane transporter activity;macromolecule transmembrane transporter activity;transition metal ion transmembrane transporter activity;heterocyclic compound binding;active transmembrane transporter activity;glycoprotein binding;P-P-bond-hydrolysis-driven protein transmembrane transporter activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;P-P-bond-hydrolysis-driven transmembrane transporter activity;transferrin transmembrane transporter activity;protein dimerization activity;transferrin receptor activity;identical protein binding;protein homodimerization activity;transporter activity;trivalent inorganic cation transmembrane transporter activity;RNA binding;protein binding;organic cyclic compound binding;cargo receptor activity;receptor activity;poly(A) RNA binding;protein transporter activity;ferric iron transmembrane transporter activity;transmembrane transporter activity; 2;5;8;6;6;3;4;10;1;2;4;5;5;9;3;4;4;6;4;7;3;5;6;7;4;5;4;5;2;8;5;3;3;4;3;6;4;9;3; K06503 map04066;map04144;map04145;map04640; HIF-1 signaling pathway;Endocytosis;Phagosome;Hematopoietic cell lineage; IPR007484;IPR029513;IPR007365;IPR003137; Peptidase M28;Transferrin receptor protein 1;Transferrin receptor-like, dimerisation domain;PA domain; plasma membrane Hs4507457 1580.0 OPR [O] Posttranslational modification, protein turnover, chaperones;[P] Inorganic ion transport and metabolism;[R] General function prediction only; Q96T51 RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2 - [RUFY1_HUMAN] 0.986 0.959 0.762 1.395 1.08 1.476 1.028154327 nan 1.291666667 nan 0.794577685 nan 1.366666667 nan GO:0051049;GO:0051128;GO:0050789;GO:0071840;GO:0032879;GO:0016043;GO:0065007;GO:0009987;GO:0006810;GO:0050794;GO:0008150;GO:0051234;GO:0030100;GO:0051179;GO:0006897;GO:0016192;GO:0060627; regulation of transport;regulation of cellular component organization;regulation of biological process;cellular component organization or biogenesis;regulation of localization;cellular component organization;biological regulation;cellular process;transport;regulation of cellular process;biological_process;establishment of localization;regulation of endocytosis;localization;endocytosis;vesicle-mediated transport;regulation of vesicle-mediated transport; 4;4;2;2;3;3;2;2;4;3;1;3;5;2;6;5;4; GO:0043229;GO:0005774;GO:0043227;GO:0043226;GO:0010008;GO:0005737;GO:0031090;GO:0005773;GO:0005634;GO:0016020;GO:0044444;GO:0044437;GO:0031901;GO:0044446;GO:0098588;GO:0012505;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044440;GO:0044424;GO:0005769;GO:0005768;GO:0098805;GO:0044422; intracellular organelle;vacuolar membrane;membrane-bounded organelle;organelle;endosome membrane;cytoplasm;organelle membrane;vacuole;nucleus;membrane;cytoplasmic part;vacuolar part;early endosome membrane;intracellular organelle part;bounding membrane of organelle;endomembrane system;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;endosomal part;intracellular part;early endosome;endosome;whole membrane;organelle part; 3;4;3;2;5;4;3;5;5;2;4;4;6;3;4;3;4;2;2;3;1;5;3;5;4;3;2; GO:0003674;GO:0005488;GO:0043169;GO:0046914;GO:0043167;GO:0046872;GO:0008565;GO:0005215;GO:0008289;GO:0022892;GO:0008270; molecular_function;binding;cation binding;transition metal ion binding;ion binding;metal ion binding;protein transporter activity;transporter activity;lipid binding;substrate-specific transporter activity;zinc ion binding; 1;2;4;6;3;5;4;2;3;3;7; K12482 map04144; Endocytosis; IPR011011;IPR013083;IPR000306;IPR017455;IPR004012;IPR001841; Zinc finger, FYVE/PHD-type;Zinc finger, RING/FYVE/PHD-type;FYVE zinc finger;Zinc finger, FYVE-related;RUN domain;Zinc finger, RING-type; cytosol Hs13376757 619.0 R [R] General function prediction only; P01772 Immunoglobulin heavy variable 3-33 OS=Homo sapiens OX=9606 GN=IGHV3-33 PE=1 SV=2 - [HV333_HUMAN] 1.041 1.126 0.681 0.919 1.445 1.112 0.924511545 nan 0.635986159 nan 0.604795737 nan 0.769550173 nan GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0006959;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;humoral immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;4;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;1;3;2;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9HB07 UPF0160 protein MYG1, mitochondrial OS=Homo sapiens OX=9606 GN=C12orf10 PE=1 SV=2 - [MYG1_HUMAN] 0.444 0.58 2.257 0.739 0.654 1.822 0.765517241 nan 1.129969419 nan 3.89137931 nan 2.785932722 nan GO:0044699;GO:0035641;GO:0035640;GO:0007626;GO:0008150;GO:0007610;GO:0043473;GO:0044708; single-organism process;locomotory exploration behavior;exploration behavior;locomotory behavior;biological_process;behavior;pigmentation;single-organism behavior; 2;4;4;3;1;2;3;3; GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070062;GO:0031981;GO:0005634;GO:0005739;GO:0005654;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0005576;GO:0044428;GO:0044424;GO:0044421;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;extracellular exosome;nuclear lumen;nucleus;mitochondrion;nucleoplasm;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;extracellular region;nuclear part;intracellular part;extracellular region part;organelle part; 2;3;3;2;4;3;4;5;5;5;5;3;4;3;4;3;2;2;3;1;4;4;2;4;3;2;2; IPR003226; Metal-dependent protein hydrolase; mitochondria Hs11056018 767.0 R [R] General function prediction only; Q6ZNJ1 Neurobeachin-like protein 2 OS=Homo sapiens OX=9606 GN=NBEAL2 PE=1 SV=2 - [NBEL2_HUMAN] 0.906 1.565 0.488 0.806 1.681 0.348 0.578913738 0.008296679 0.479476502 0.002295293 0.311821086 0.002036307 0.207019631 0.000697827 GO:0030154;GO:0048468;GO:0030220;GO:0007275;GO:0044699;GO:0002376;GO:0000904;GO:0000902;GO:0036344;GO:0048869;GO:0016043;GO:0032989;GO:0048513;GO:0071840;GO:0048534;GO:0048646;GO:0032502;GO:0032501;GO:0009987;GO:0044767;GO:0008150;GO:0048731;GO:0002520;GO:0044707;GO:0048856;GO:0030097;GO:0009653;GO:0030099;GO:0044763; cell differentiation;cell development;platelet formation;multicellular organism development;single-organism process;immune system process;cell morphogenesis involved in differentiation;cell morphogenesis;platelet morphogenesis;cellular developmental process;cellular component organization;cellular component morphogenesis;animal organ development;cellular component organization or biogenesis;hematopoietic or lymphoid organ development;anatomical structure formation involved in morphogenesis;developmental process;multicellular organismal process;cellular process;single-organism developmental process;biological_process;system development;immune system development;single-multicellular organism process;anatomical structure development;hemopoiesis;anatomical structure morphogenesis;myeloid cell differentiation;single-organism cellular process; 5;4;4;4;2;2;5;5;6;4;3;4;4;2;4;3;2;2;2;3;1;4;3;3;3;5;3;6;3; GO:0043231;GO:0005783;GO:0019898;GO:0043226;GO:0043229;GO:0043227;GO:0016020;GO:0044425;GO:0005737;GO:0012505;GO:0005622;GO:0044464;GO:0005623;GO:0005575;GO:0044444;GO:0044424; intracellular membrane-bounded organelle;endoplasmic reticulum;extrinsic component of membrane;organelle;intracellular organelle;membrane-bounded organelle;membrane;membrane part;cytoplasm;endomembrane system;intracellular;cell part;cell;cellular_component;cytoplasmic part;intracellular part; 4;4;3;2;3;3;2;2;4;3;3;2;2;1;4;3; GO:0005543;GO:0003674;GO:0005488;GO:0043167;GO:0043168;GO:0008289; phospholipid binding;molecular_function;binding;ion binding;anion binding;lipid binding; 4;1;2;3;4;3; K23286 IPR016024;IPR017986;IPR001680;IPR015943;IPR031570;IPR011042;IPR013320;IPR011993;IPR011989;IPR023362;IPR000409; Armadillo-type fold;WD40-repeat-containing domain;WD40 repeat;WD40/YVTN repeat-like-containing domain;Domain of unknown function DUF4704;Six-bladed beta-propeller, TolB-like;Concanavalin A-like lectin/glucanase domain;PH domain-like;Armadillo-like helical;PH-BEACH domain;BEACH domain; plasma membrane Hs22042385 2840.0 U [U] Intracellular trafficking, secretion, and vesicular transport; P10243 Myb-related protein A OS=Homo sapiens OX=9606 GN=MYBL1 PE=1 SV=2 - [MYBA_HUMAN] 0.72 1.023 1.799 0.648 0.892 0.648 0.703812317 nan 0.726457399 nan 1.758553275 nan 0.726457399 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0010604;GO:0016458;GO:0048518;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0010629;GO:0019438;GO:0009892;GO:0009893;GO:0009891;GO:0010628;GO:0034660;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0031047;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0006807;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0034587;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;gene silencing;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;negative regulation of gene expression;aromatic compound biosynthetic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of gene expression;ncRNA metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;gene silencing by RNA;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;piRNA metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;5;4;4;4;4;2;2;4;6;4;5;5;3;3;4;5;6;7;4;4;2;7;5;4;3;1;2;5;5;5;6;5;5;6;5;6;4;4;5;2;4;7;2;4;7;6;5;5;4;6;3;7;5;5;4;4;5;7;6;2;3;5;7;5;5;5;3;5;3;4;4;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleus;cell part;cell;cellular_component; 4;3;3;3;3;2;5;2;2;1; GO:0001077;GO:0001071;GO:1901363;GO:0001067;GO:0044212;GO:0001012;GO:0001159;GO:0001228;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000987;GO:0000982;GO:0000981;GO:0043565;GO:0097159;GO:0000976;GO:0000975;GO:0000978;GO:1990837;GO:0003690;GO:0000977;GO:0003700; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;nucleic acid binding transcription factor activity;heterocyclic compound binding;regulatory region nucleic acid binding;transcription regulatory region DNA binding;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;molecular_function;binding;nucleic acid binding;DNA binding;core promoter proximal region sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 6;2;3;5;7;8;8;5;1;2;4;5;9;5;4;6;3;8;6;10;7;6;9;3; K09421 map05166; HTLV-I infection; IPR015395;IPR001005;IPR012642;IPR017930;IPR009057; C-myb, C-terminal;SANT/Myb domain;Transcription regulator Wos2-domain;Myb domain;Homeobox domain-like; nucleus Q9NZ43 Vesicle transport protein USE1 OS=Homo sapiens OX=9606 GN=USE1 PE=1 SV=2 - [USE1_HUMAN] 0.912 0.95 1.052 1.243 0.846 1.805 0.96 nan 1.469267139 nan 1.107368421 nan 2.13356974 nan GO:0008104;GO:0007041;GO:0043170;GO:1901575;GO:0071704;GO:0009057;GO:0008150;GO:0044699;GO:0071702;GO:0033036;GO:0016192;GO:0009987;GO:0006810;GO:0045184;GO:0015031;GO:0044765;GO:0044763;GO:0008152;GO:0051649;GO:0051234;GO:0009056;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0046903;GO:1902582;GO:0007034;GO:0019538;GO:0032940;GO:0046907;GO:0030163; protein localization;lysosomal transport;macromolecule metabolic process;organic substance catabolic process;organic substance metabolic process;macromolecule catabolic process;biological_process;single-organism process;organic substance transport;macromolecule localization;vesicle-mediated transport;cellular process;transport;establishment of protein localization;protein transport;single-organism transport;single-organism cellular process;metabolic process;establishment of localization in cell;establishment of localization;catabolic process;localization;single-organism localization;cellular localization;primary metabolic process;secretion;single-organism intracellular transport;vacuolar transport;protein metabolic process;secretion by cell;intracellular transport;protein catabolic process; 4;7;4;4;3;5;1;2;5;3;5;2;4;4;5;4;3;2;4;3;3;2;3;3;3;5;5;6;4;4;5;5; GO:0005783;GO:0005789;GO:0042175;GO:0043229;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0044446;GO:0031090;GO:0016021;GO:0016020;GO:0044432;GO:0098588;GO:0012505;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044425;GO:0044422; endoplasmic reticulum;endoplasmic reticulum membrane;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;intracellular organelle part;organelle membrane;integral component of membrane;membrane;endoplasmic reticulum part;bounding membrane of organelle;endomembrane system;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;membrane part;organelle part; 4;3;3;3;3;2;3;4;3;3;4;2;4;4;3;4;2;2;3;1;4;3;2;2; K08507 map04130; SNARE interactions in vesicular transport; IPR019150; Vesicle transport protein, Use1; peroxisome Hs8923936 525.0 S [S] Function unknown; Q15063 Periostin OS=Homo sapiens OX=9606 GN=POSTN PE=1 SV=2 - [POSTN_HUMAN] 1.375 1.003 0.814 1.305 0.89 0.557 1.370887338 nan 1.466292135 nan 0.811565304 nan 0.625842697 nan GO:0008104;GO:0051046;GO:0051047;GO:0051049;GO:0048468;GO:0001501;GO:0007162;GO:0003013;GO:0007165;GO:0007166;GO:0071840;GO:0051716;GO:0007219;GO:0048589;GO:0007160;GO:0009966;GO:0034446;GO:0070848;GO:0009612;GO:0016049;GO:0010721;GO:0048518;GO:0048519;GO:0033036;GO:0032722;GO:0031589;GO:1990138;GO:0051050;GO:0048583;GO:0071496;GO:0043062;GO:0045184;GO:0031669;GO:0040007;GO:0010033;GO:0003008;GO:0044700;GO:0031668;GO:0065008;GO:0014823;GO:0009605;GO:0044707;GO:0048870;GO:0008015;GO:0031667;GO:0007154;GO:0030198;GO:0007584;GO:0035926;GO:0022604;GO:0032642;GO:0042246;GO:0023051;GO:0014812;GO:0006928;GO:0032940;GO:0051674;GO:0031175;GO:0060560;GO:0051222;GO:0051223;GO:0050789;GO:0003073;GO:0071295;GO:0001666;GO:0050708;GO:0000902;GO:0071560;GO:0071356;GO:0031670;GO:0050707;GO:0044344;GO:0016043;GO:0009306;GO:0065007;GO:0014070;GO:0048588;GO:0016477;GO:0010812;GO:0070201;GO:0090196;GO:0034097;GO:0090195;GO:0090197;GO:0006810;GO:0009888;GO:0042060;GO:0050794;GO:0006950;GO:0008150;GO:0051239;GO:0032571;GO:0051234;GO:0046903;GO:0050715;GO:0050714;GO:0071345;GO:0036293;GO:0050896;GO:0048812;GO:2000145;GO:2000147;GO:0048869;GO:0071774;GO:0097305;GO:1900024;GO:1900025;GO:0030155;GO:0030154;GO:0009991;GO:0051129;GO:0051128;GO:0007155;GO:0023052;GO:1903530;GO:0070887;GO:1903532;GO:0001953;GO:1904951;GO:0044699;GO:0032880;GO:0009719;GO:0009653;GO:0051240;GO:0022603;GO:0031099;GO:0060284;GO:0030030;GO:0010769;GO:0033273;GO:0001952;GO:0070482;GO:0032502;GO:1901700;GO:0014909;GO:0009628;GO:0009611;GO:0009987;GO:0045596;GO:0045595;GO:0051270;GO:1901701;GO:0098602;GO:0032879;GO:0032990;GO:0051093;GO:0022610;GO:0071363;GO:0007399;GO:0009725;GO:0001816;GO:0001817;GO:0010771;GO:0048731;GO:0048545;GO:0001819;GO:2000343;GO:1904207;GO:2000341;GO:0060341;GO:0014911;GO:0014910;GO:0032602;GO:0050793;GO:1904209;GO:0032501;GO:0008217;GO:0007275;GO:0050663;GO:0032355;GO:0010646;GO:0072567;GO:0033993;GO:0032989;GO:0071310;GO:1901655;GO:0071702;GO:0071559;GO:0048666;GO:1990523;GO:0030335;GO:0030334;GO:0071307;GO:0030182;GO:0010810;GO:0034612;GO:0044767;GO:0014850;GO:0044765;GO:0000904;GO:0044763;GO:0008593;GO:0043627;GO:0042221;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0051272;GO:0048699;GO:0040012;GO:0048858;GO:0040017;GO:0048856;GO:1901654;GO:0071495;GO:0015031;GO:0048523;GO:0048522; protein localization;regulation of secretion;positive regulation of secretion;regulation of transport;cell development;skeletal system development;negative regulation of cell adhesion;circulatory system process;signal transduction;cell surface receptor signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;Notch signaling pathway;developmental growth;cell-matrix adhesion;regulation of signal transduction;substrate adhesion-dependent cell spreading;response to growth factor;response to mechanical stimulus;cell growth;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;macromolecule localization;positive regulation of chemokine production;cell-substrate adhesion;neuron projection extension;positive regulation of transport;regulation of response to stimulus;cellular response to external stimulus;extracellular structure organization;establishment of protein localization;cellular response to nutrient levels;growth;response to organic substance;system process;single organism signaling;cellular response to extracellular stimulus;regulation of biological quality;response to activity;response to external stimulus;single-multicellular organism process;cell motility;blood circulation;response to nutrient levels;cell communication;extracellular matrix organization;response to nutrient;chemokine (C-C motif) ligand 2 secretion;regulation of cell morphogenesis;regulation of chemokine production;tissue regeneration;regulation of signaling;muscle cell migration;movement of cell or subcellular component;secretion by cell;localization of cell;neuron projection development;developmental growth involved in morphogenesis;positive regulation of protein transport;regulation of protein transport;regulation of biological process;regulation of systemic arterial blood pressure;cellular response to vitamin;response to hypoxia;regulation of protein secretion;cell morphogenesis;cellular response to transforming growth factor beta stimulus;cellular response to tumor necrosis factor;cellular response to nutrient;regulation of cytokine secretion;cellular response to fibroblast growth factor stimulus;cellular component organization;protein secretion;biological regulation;response to organic cyclic compound;developmental cell growth;cell migration;negative regulation of cell-substrate adhesion;regulation of establishment of protein localization;regulation of chemokine secretion;response to cytokine;chemokine secretion;positive regulation of chemokine secretion;transport;tissue development;wound healing;regulation of cellular process;response to stress;biological_process;regulation of multicellular organismal process;response to vitamin K;establishment of localization;secretion;positive regulation of cytokine secretion;positive regulation of protein secretion;cellular response to cytokine stimulus;response to decreased oxygen levels;response to stimulus;neuron projection morphogenesis;regulation of cell motility;positive regulation of cell motility;cellular developmental process;response to fibroblast growth factor;response to alcohol;regulation of substrate adhesion-dependent cell spreading;negative regulation of substrate adhesion-dependent cell spreading;regulation of cell adhesion;cell differentiation;response to extracellular stimulus;negative regulation of cellular component organization;regulation of cellular component organization;cell adhesion;signaling;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;negative regulation of cell-matrix adhesion;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;response to endogenous stimulus;anatomical structure morphogenesis;positive regulation of multicellular organismal process;regulation of anatomical structure morphogenesis;regeneration;regulation of cell development;cell projection organization;regulation of cell morphogenesis involved in differentiation;response to vitamin;regulation of cell-matrix adhesion;response to oxygen levels;developmental process;response to oxygen-containing compound;smooth muscle cell migration;response to abiotic stimulus;response to wounding;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cellular component movement;cellular response to oxygen-containing compound;single organism cell adhesion;regulation of localization;cell part morphogenesis;negative regulation of developmental process;biological adhesion;cellular response to growth factor stimulus;nervous system development;response to hormone;cytokine production;regulation of cytokine production;negative regulation of cell morphogenesis involved in differentiation;system development;response to steroid hormone;positive regulation of cytokine production;positive regulation of chemokine (C-X-C motif) ligand 2 production;regulation of chemokine (C-C motif) ligand 2 secretion;regulation of chemokine (C-X-C motif) ligand 2 production;regulation of cellular localization;positive regulation of smooth muscle cell migration;regulation of smooth muscle cell migration;chemokine production;regulation of developmental process;positive regulation of chemokine (C-C motif) ligand 2 secretion;multicellular organismal process;regulation of blood pressure;multicellular organism development;cytokine secretion;response to estradiol;regulation of cell communication;chemokine (C-X-C motif) ligand 2 production;response to lipid;cellular component morphogenesis;cellular response to organic substance;cellular response to ketone;organic substance transport;response to transforming growth factor beta;neuron development;bone regeneration;positive regulation of cell migration;regulation of cell migration;cellular response to vitamin K;neuron differentiation;regulation of cell-substrate adhesion;response to tumor necrosis factor;single-organism developmental process;response to muscle activity;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;regulation of Notch signaling pathway;response to estrogen;response to chemical;neurogenesis;localization;single-organism localization;cellular localization;locomotion;positive regulation of cellular component movement;generation of neurons;regulation of locomotion;cell projection morphogenesis;positive regulation of locomotion;anatomical structure development;response to ketone;cellular response to endogenous stimulus;protein transport;negative regulation of cellular process;positive regulation of cellular process; 4;5;4;4;4;5;4;4;4;5;2;3;6;3;5;4;4;5;4;3;5;2;2;3;5;4;5;3;3;4;4;4;5;2;4;3;3;4;3;3;3;3;3;5;5;4;5;4;7;5;5;4;3;5;4;4;3;5;4;4;5;2;5;6;4;6;5;5;7;5;5;5;3;5;2;5;4;4;5;5;6;5;6;6;4;4;5;3;3;1;3;6;3;5;5;5;6;5;2;6;4;4;4;4;5;5;5;4;5;4;4;4;3;2;5;4;4;6;3;2;4;3;3;3;4;4;5;4;6;5;6;4;2;4;6;3;4;2;4;4;4;5;3;3;5;3;2;6;5;4;4;4;5;4;5;4;6;7;6;4;6;6;5;3;7;2;4;4;5;6;4;6;5;4;5;6;5;4;5;5;5;5;7;6;5;6;3;4;4;5;3;5;6;3;6;2;3;3;2;4;7;3;5;3;3;5;4;5;3;3; GO:0031594;GO:0005615;GO:0005794;GO:0043231;GO:0044424;GO:0044421;GO:0044422;GO:0043227;GO:0044431;GO:0031984;GO:0012505;GO:0031012;GO:0044444;GO:0043226;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005802;GO:0045202;GO:0044446;GO:0005737;GO:0005575;GO:0005576;GO:0098791;GO:0005578; neuromuscular junction;extracellular space;Golgi apparatus;intracellular membrane-bounded organelle;intracellular part;extracellular region part;organelle part;membrane-bounded organelle;Golgi apparatus part;organelle subcompartment;endomembrane system;extracellular matrix;cytoplasmic part;organelle;cell part;intracellular organelle;cell;intracellular;trans-Golgi network;synapse;intracellular organelle part;cytoplasm;cellular_component;extracellular region;Golgi subcompartment;proteinaceous extracellular matrix; 3;3;4;4;3;2;2;3;4;4;3;2;4;2;2;3;2;3;5;2;3;4;1;2;5;3; GO:0050839;GO:0097367;GO:0003674;GO:0005488;GO:0043168;GO:1901681;GO:0043169;GO:0043167;GO:0008201;GO:0005515;GO:0005539;GO:0046872; cell adhesion molecule binding;carbohydrate derivative binding;molecular_function;binding;anion binding;sulfur compound binding;cation binding;ion binding;heparin binding;protein binding;glycosaminoglycan binding;metal ion binding; 4;3;1;2;4;3;4;3;4;3;4;5; IPR011489;IPR016666;IPR000782; EMI domain;TGF beta-induced protein/periostin;FAS1 domain; endoplasmic reticulum Hs5453834 1704.0 MW [M] Cell wall/membrane/envelope biogenesis;[W] Extracellular structures; P00748 Coagulation factor XII OS=Homo sapiens OX=9606 GN=F12 PE=1 SV=3 - [FA12_HUMAN] 1.12 0.93 0.94 1.141 0.925 1.259 1.204301075 3.92E-06 1.233513514 1.89E-07 1.010752688 0.126743151 1.361081081 3.40E-07 GO:0007599;GO:0080090;GO:0019222;GO:0048585;GO:0007596;GO:0048583;GO:0031349;GO:0031347;GO:0032103;GO:0044710;GO:0050729;GO:0010604;GO:0050727;GO:0048518;GO:0048519;GO:0007597;GO:0048584;GO:0060255;GO:0030162;GO:0002673;GO:0010033;GO:0002675;GO:0009605;GO:0044707;GO:0019538;GO:0002376;GO:0030193;GO:0051788;GO:0030195;GO:0030194;GO:0009893;GO:0008152;GO:0050820;GO:0010628;GO:0050789;GO:0044267;GO:0044260;GO:1900046;GO:1900047;GO:0065007;GO:0065008;GO:1900048;GO:0042060;GO:0050794;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0006954;GO:0006955;GO:0002526;GO:0050818;GO:0050819;GO:0042730;GO:0070613;GO:0051604;GO:0016540;GO:0050896;GO:0002353;GO:1903319;GO:1903317;GO:0032102;GO:0051239;GO:0032101;GO:0009611;GO:0044699;GO:0051240;GO:0051241;GO:0051246;GO:0051247;GO:0051917;GO:0032270;GO:0006508;GO:1903034;GO:1903035;GO:1903036;GO:0051919;GO:0032501;GO:0050878;GO:0009987;GO:0016485;GO:0032268;GO:0002541;GO:0002542;GO:0043170;GO:0035966;GO:0045862;GO:0080134;GO:0031325;GO:0031323;GO:0061041;GO:0061045;GO:0090303;GO:0072376;GO:0072378;GO:0031639;GO:0031638;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0042221;GO:0010954;GO:0044238;GO:0044237;GO:0002254;GO:0010756;GO:0010755;GO:0048522; hemostasis;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;positive regulation of defense response;regulation of defense response;positive regulation of response to external stimulus;single-organism metabolic process;positive regulation of inflammatory response;positive regulation of macromolecule metabolic process;regulation of inflammatory response;positive regulation of biological process;negative regulation of biological process;blood coagulation, intrinsic pathway;positive regulation of response to stimulus;regulation of macromolecule metabolic process;regulation of proteolysis;regulation of acute inflammatory response;response to organic substance;positive regulation of acute inflammatory response;response to external stimulus;single-multicellular organism process;protein metabolic process;immune system process;regulation of blood coagulation;response to misfolded protein;negative regulation of blood coagulation;positive regulation of blood coagulation;positive regulation of metabolic process;metabolic process;positive regulation of coagulation;positive regulation of gene expression;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of hemostasis;negative regulation of hemostasis;biological regulation;regulation of biological quality;positive regulation of hemostasis;wound healing;regulation of cellular process;defense response;response to stress;coagulation;biological_process;inflammatory response;immune response;acute inflammatory response;regulation of coagulation;negative regulation of coagulation;fibrinolysis;regulation of protein processing;protein maturation;protein autoprocessing;response to stimulus;plasma kallikrein-kinin cascade;positive regulation of protein maturation;regulation of protein maturation;negative regulation of response to external stimulus;regulation of multicellular organismal process;regulation of response to external stimulus;response to wounding;single-organism process;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of fibrinolysis;positive regulation of cellular protein metabolic process;proteolysis;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;positive regulation of fibrinolysis;multicellular organismal process;regulation of body fluid levels;cellular process;protein processing;regulation of cellular protein metabolic process;activation of plasma proteins involved in acute inflammatory response;Factor XII activation;macromolecule metabolic process;response to topologically incorrect protein;positive regulation of proteolysis;regulation of response to stress;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of wound healing;negative regulation of wound healing;positive regulation of wound healing;protein activation cascade;blood coagulation, fibrin clot formation;plasminogen activation;zymogen activation;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;response to chemical;positive regulation of protein processing;primary metabolic process;cellular metabolic process;kinin cascade;positive regulation of plasminogen activation;regulation of plasminogen activation;positive regulation of cellular process; 5;4;3;3;5;3;4;5;4;3;5;4;5;2;2;4;3;4;6;6;4;6;3;3;4;2;5;5;5;5;3;2;4;5;2;5;4;4;4;2;3;4;5;3;4;3;4;1;5;3;6;4;4;6;7;5;7;2;5;6;6;4;3;4;4;2;3;3;5;5;6;5;5;5;4;4;3;2;4;2;6;5;7;6;4;4;6;4;4;4;6;5;5;3;4;8;7;3;5;5;4;3;7;3;3;4;8;8;3; GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0031982;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:0005576;GO:0005886;GO:1903561;GO:0005615;GO:0005575; membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;vesicle;cell part;cell;cell periphery;extracellular exosome;organelle;extracellular region;plasma membrane;extracellular vesicle;extracellular space;cellular_component; 2;3;2;3;4;2;2;3;4;2;2;3;3;3;1; GO:0004252;GO:0017171;GO:0051787;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0005515;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;misfolded protein binding;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;protein binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;4;1;2;3;2;4;5;3;6;5; K01328 map04610; Complement and coagulation cascades; IPR001254;IPR018056;IPR014394;IPR000083;IPR000742;IPR013806;IPR009003;IPR000001;IPR001314;IPR000562;IPR001881;IPR013032;IPR033116;IPR018114; Serine proteases, trypsin domain;Kringle, conserved site;Coagulation factor XII/hepatocyte growth factor activator;Fibronectin, type I;EGF-like domain;Kringle-like fold;Peptidase S1, PA clan;Kringle;Peptidase S1A, chymotrypsin family;Fibronectin, type II, collagen-binding;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site; extracellular Hs4503629_1 652.0 T [T] Signal transduction mechanisms; O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2 - [U520_HUMAN] 1.252 1.16 0.676 0.945 1.315 0.609 1.079310345 nan 0.718631179 nan 0.582758621 nan 0.463117871 nan GO:0000245;GO:0001503;GO:1901360;GO:0065003;GO:0048869;GO:0046483;GO:0044707;GO:0000398;GO:0022607;GO:0006807;GO:0043170;GO:0044260;GO:0016043;GO:0071840;GO:0008150;GO:0008152;GO:0016070;GO:0016071;GO:0030154;GO:0034641;GO:0044699;GO:0006139;GO:0022618;GO:0022613;GO:0008380;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:0000354;GO:0045292;GO:0043933;GO:0090304;GO:0034622;GO:0044767;GO:0071826;GO:0071704;GO:0010467;GO:0001649;GO:0000375;GO:0000377;GO:0044763;GO:0044238;GO:0044237;GO:0044085;GO:0006396;GO:0006397; spliceosomal complex assembly;ossification;organic cyclic compound metabolic process;macromolecular complex assembly;cellular developmental process;heterocycle metabolic process;single-multicellular organism process;mRNA splicing, via spliceosome;cellular component assembly;nitrogen compound metabolic process;macromolecule metabolic process;cellular macromolecule metabolic process;cellular component organization;cellular component organization or biogenesis;biological_process;metabolic process;RNA metabolic process;mRNA metabolic process;cell differentiation;cellular nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;RNA splicing;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;cis assembly of pre-catalytic spliceosome;mRNA cis splicing, via spliceosome;macromolecular complex subunit organization;nucleic acid metabolic process;cellular macromolecular complex assembly;single-organism developmental process;ribonucleoprotein complex subunit organization;organic substance metabolic process;gene expression;osteoblast differentiation;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;single-organism cellular process;primary metabolic process;cellular metabolic process;cellular component biogenesis;RNA processing;mRNA processing; 6;4;4;5;4;4;3;8;4;3;4;4;3;2;1;2;5;6;5;4;2;4;5;4;7;2;2;2;4;6;9;4;5;6;3;5;3;5;5;8;9;3;3;3;3;6;7; GO:0031974;GO:0031981;GO:0016020;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:1990904;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0097525;GO:0030529;GO:0071013;GO:0032991;GO:0030532;GO:0005575;GO:0070013;GO:0005682;GO:0005681; membrane-enclosed lumen;nuclear lumen;membrane;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;ribonucleoprotein complex;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;cell;intracellular;spliceosomal snRNP complex;intracellular ribonucleoprotein complex;catalytic step 2 spliceosome;macromolecular complex;small nuclear ribonucleoprotein complex;cellular_component;intracellular organelle lumen;U5 snRNP;spliceosomal complex; 2;5;2;4;3;4;3;2;3;3;3;2;5;3;5;2;2;3;6;4;6;2;5;1;4;7;5; GO:0008186;GO:1901363;GO:0000166;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008026;GO:0035639;GO:0043168;GO:0043167;GO:0042802;GO:0044822;GO:0030554;GO:0003724;GO:0003723;GO:0005515;GO:0016887;GO:0001883;GO:0001882;GO:0017111;GO:0004004;GO:0036094; RNA-dependent ATPase activity;heterocyclic compound binding;nucleotide binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;anion binding;ion binding;identical protein binding;poly(A) RNA binding;adenyl nucleotide binding;RNA helicase activity;RNA binding;protein binding;ATPase activity;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;ATP-dependent RNA helicase activity;small molecule binding; 10;3;4;8;5;3;4;9;1;2;4;4;9;5;5;6;3;2;3;6;6;5;6;4;10;5;4;3;4;6;6;9;5;3;8;5;4;7;10;3; K12854 map03040; Spliceosome; IPR004179;IPR011545;IPR001650;IPR014756;IPR014001;IPR011991;IPR000008;IPR027417; Sec63 domain;DEAD/DEAH box helicase domain;Helicase, C-terminal;Immunoglobulin E-set;Helicase superfamily 1/2, ATP-binding domain;Winged helix-turn-helix DNA-binding domain;C2 domain;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs22042312 4437.0 A [A] RNA processing and modification; P41091 Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3 - [IF2G_HUMAN] 1.026 1.413 0.73 0.915 1.254 0.567 0.72611465 0.688987087 0.729665072 0.6964479 0.516631281 0.270779021 0.45215311 0.232118747 GO:0071840;GO:0043043;GO:1901564;GO:1901566;GO:0019538;GO:0022607;GO:0006807;GO:0044267;GO:0044260;GO:0016043;GO:0065003;GO:0006810;GO:0008150;GO:0008152;GO:0051234;GO:0044271;GO:0044765;GO:0006518;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0022618;GO:0022613;GO:0055085;GO:0043604;GO:0043603;GO:0043170;GO:0043933;GO:0034622;GO:0071826;GO:0071704;GO:0010467;GO:0009987;GO:1901576;GO:0009058;GO:0009059;GO:0044763;GO:0001731;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0044085;GO:0006413;GO:0006412; cellular component organization or biogenesis;peptide biosynthetic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular component assembly;nitrogen compound metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;transport;biological_process;metabolic process;establishment of localization;cellular nitrogen compound biosynthetic process;single-organism transport;peptide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;transmembrane transport;amide biosynthetic process;cellular amide metabolic process;macromolecule metabolic process;macromolecular complex subunit organization;cellular macromolecular complex assembly;ribonucleoprotein complex subunit organization;organic substance metabolic process;gene expression;cellular process;organic substance biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;formation of translation preinitiation complex;localization;single-organism localization;primary metabolic process;cellular metabolic process;cellular component biogenesis;translational initiation;translation; 2;6;4;5;4;4;3;5;4;3;5;4;1;2;3;5;4;5;4;4;5;2;5;4;4;6;5;4;4;6;5;3;5;2;4;3;5;3;5;2;3;3;3;3;4;6; GO:0031982;GO:0043230;GO:0005829;GO:0044424;GO:0044421;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0044444;GO:0044464;GO:0005623;GO:0070062;GO:0005576;GO:1903561;GO:0005575; vesicle;extracellular organelle;cytosol;intracellular part;extracellular region part;intracellular;membrane-bounded organelle;organelle;cytoplasm;cytoplasmic part;cell part;cell;extracellular exosome;extracellular region;extracellular vesicle;cellular_component; 4;3;5;3;2;3;3;2;4;4;2;2;4;2;3;1; GO:1901363;GO:0000166;GO:0003924;GO:0016818;GO:0097367;GO:0016817;GO:0016787;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0003824;GO:0097159;GO:0016462;GO:0032555;GO:0032550;GO:0032553;GO:0003743;GO:0035639;GO:0043168;GO:0043167;GO:0032561;GO:0008135;GO:0003723;GO:0001883;GO:0001882;GO:0019001;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;GTPase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;hydrolase activity;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;translation initiation factor activity;purine ribonucleoside triphosphate binding;anion binding;ion binding;guanyl ribonucleotide binding;translation factor activity, RNA binding;RNA binding;purine nucleoside binding;nucleoside binding;guanyl nucleotide binding;nucleoside-triphosphatase activity;small molecule binding; 3;4;8;5;3;4;3;1;2;4;4;5;5;6;2;3;6;5;6;4;7;5;4;3;6;6;5;5;4;6;7;3; K03242 map03013; RNA transport; IPR000795;IPR004161;IPR009001;IPR009000;IPR015256;IPR027417; Transcription factor, GTP-binding domain;Translation elongation factor EFTu-like, domain 2;Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal;Translation protein, beta-barrel domain;Translation initiation factor 2, gamma subunit, C-terminal;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs4503507 962.0 J [J] Translation, ribosomal structure and biogenesis; P36575 Arrestin-C OS=Homo sapiens OX=9606 GN=ARR3 PE=1 SV=2 - [ARRC_HUMAN] 1.226 0.959 0.969 0.952 1.028 1.052 1.278415016 0.038394456 0.926070039 0.505872204 1.010427529 0.900152974 1.023346304 0.870176293 GO:0019220;GO:0080090;GO:0019222;GO:0016310;GO:0031323;GO:0023052;GO:0043170;GO:0050789;GO:0044699;GO:0044237;GO:0044267;GO:0051716;GO:0044260;GO:0071704;GO:0051246;GO:0065007;GO:0031399;GO:0006468;GO:0032501;GO:0044700;GO:0060255;GO:0050877;GO:0006810;GO:0007601;GO:0007600;GO:0050953;GO:0050794;GO:0051174;GO:0043412;GO:0036211;GO:0008150;GO:0006464;GO:0008152;GO:0007154;GO:0051234;GO:0051179;GO:0003008;GO:0042325;GO:0044238;GO:0032268;GO:0006897;GO:0016192;GO:0019538;GO:0050896;GO:0006796;GO:0006793;GO:0044763;GO:0009987;GO:0001932;GO:0007165; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;phosphorylation;regulation of cellular metabolic process;signaling;macromolecule metabolic process;regulation of biological process;single-organism process;cellular metabolic process;cellular protein metabolic process;cellular response to stimulus;cellular macromolecule metabolic process;organic substance metabolic process;regulation of protein metabolic process;biological regulation;regulation of protein modification process;protein phosphorylation;multicellular organismal process;single organism signaling;regulation of macromolecule metabolic process;neurological system process;transport;visual perception;sensory perception;sensory perception of light stimulus;regulation of cellular process;regulation of phosphorus metabolic process;macromolecule modification;protein modification process;biological_process;cellular protein modification process;metabolic process;cell communication;establishment of localization;localization;system process;regulation of phosphorylation;primary metabolic process;regulation of cellular protein metabolic process;endocytosis;vesicle-mediated transport;protein metabolic process;response to stimulus;phosphate-containing compound metabolic process;phosphorus metabolic process;single-organism cellular process;cellular process;regulation of protein phosphorylation;signal transduction; 6;4;3;6;4;2;4;2;2;3;5;3;4;3;5;2;6;7;2;3;4;4;4;7;5;6;3;5;5;5;1;6;2;4;3;2;3;7;3;5;6;5;4;2;5;4;3;2;7;4; GO:0042995;GO:0043226;GO:0045202;GO:0005929;GO:0005737;GO:0072372;GO:0001750;GO:0031513;GO:0097458;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0001917;GO:0044424; cell projection;organelle;synapse;cilium;cytoplasm;primary cilium;photoreceptor outer segment;nonmotile primary cilium;neuron part;cell part;cell;intracellular;cellular_component;photoreceptor inner segment;intracellular part; 3;2;2;3;4;4;4;5;3;2;2;3;1;4;3; K13801 IPR017864;IPR033042;IPR014753;IPR000698;IPR011022;IPR014756;IPR011021; Arrestin, conserved site;Arrestin-C;Arrestin, N-terminal;Arrestin;Arrestin C-terminal-like domain;Immunoglobulin E-set;Arrestin-like, N-terminal; cytosol Hs4757776 795.0 T [T] Signal transduction mechanisms; P45973 Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1 - [CBX5_HUMAN] 1.047 1.043 1.069 1.006 1.028 0.833 1.003835091 0.988601722 0.978599222 0.901197162 1.024928092 0.889539401 0.810311284 0.186541562 GO:0080090;GO:0019222;GO:0007596;GO:0007599;GO:1901362;GO:0044707;GO:1901360;GO:0010605;GO:0009611;GO:0044419;GO:0048519;GO:0046483;GO:0060255;GO:2001141;GO:0019438;GO:0009892;GO:0009890;GO:0043170;GO:1901576;GO:0044260;GO:0065007;GO:0065008;GO:0018130;GO:0009889;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0034654;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0016070;GO:0032501;GO:0050878;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0044764;GO:0051253;GO:0051252;GO:0010629;GO:0006807;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0097659;GO:0051704;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0016032;GO:0044403;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;blood coagulation;hemostasis;organic cyclic compound biosynthetic process;single-multicellular organism process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;response to wounding;interspecies interaction between organisms;negative regulation of biological process;heterocycle metabolic process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;macromolecule metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;regulation of biological quality;heterocycle biosynthetic process;regulation of biosynthetic process;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;RNA metabolic process;multicellular organismal process;regulation of body fluid levels;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;multi-organism cellular process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;nitrogen compound metabolic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;nucleic acid-templated transcription;multi-organism process;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;viral process;symbiosis, encompassing mutualism through parasitism;negative regulation of cellular process; 4;3;5;5;5;3;4;4;4;3;2;4;4;6;5;3;4;4;4;4;2;3;5;4;5;3;3;4;1;2;5;5;2;6;5;6;5;6;4;4;5;2;4;5;2;4;2;4;7;7;6;3;5;5;5;3;5;5;4;4;5;6;6;2;3;5;7;2;5;5;5;6;3;5;4;4;3;3;4;4;3; GO:0031974;GO:0031975;GO:0031618;GO:0031981;GO:1902494;GO:0031967;GO:0000792;GO:0000790;GO:1990234;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0010369;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0000781;GO:0043229;GO:0043228;GO:0000785;GO:0000228;GO:0043227;GO:0043226;GO:0034708;GO:0005654;GO:0012505;GO:0098687;GO:0005720;GO:0005721;GO:0035097;GO:0044446;GO:0005730;GO:0005634;GO:0005635;GO:0044454;GO:0044451;GO:0000118;GO:0044464;GO:0005623;GO:0005622;GO:0000784;GO:0005694;GO:0017053;GO:0000775;GO:0000776;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;nuclear pericentric heterochromatin;nuclear lumen;catalytic complex;organelle envelope;heterochromatin;nuclear chromatin;transferase complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;chromocenter;nuclear part;intracellular part;chromosomal part;organelle part;chromosome, telomeric region;intracellular organelle;non-membrane-bounded organelle;chromatin;nuclear chromosome;membrane-bounded organelle;organelle;methyltransferase complex;nucleoplasm;endomembrane system;chromosomal region;nuclear heterochromatin;pericentric heterochromatin;histone methyltransferase complex;intracellular organelle part;nucleolus;nucleus;nuclear envelope;nuclear chromosome part;nucleoplasm part;histone deacetylase complex;cell part;cell;intracellular;nuclear chromosome, telomeric region;chromosome;transcriptional repressor complex;chromosome, centromeric region;kinetochore;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;6;5;4;4;4;4;5;3;4;4;3;6;4;3;4;2;6;3;3;3;5;3;2;4;5;3;5;5;5;5;3;5;5;4;5;5;5;2;2;3;6;5;4;6;4;2;1;4; GO:0035064;GO:0060090;GO:0042393;GO:0005488;GO:0030674;GO:0008134;GO:0005515;GO:0044877;GO:0003682;GO:0003674;GO:0070491; methylated histone binding;binding, bridging;histone binding;binding;protein binding, bridging;transcription factor binding;protein binding;macromolecular complex binding;chromatin binding;molecular_function;repressing transcription factor binding; 5;3;4;2;4;4;3;3;4;1;5; K11587 IPR008251;IPR023780;IPR017984;IPR016197;IPR000953;IPR023779; Chromo shadow domain;Chromo domain;Chromo domain subgroup;Chromo domain-like;Chromo/chromo shadow domain;Chromo domain, conserved site; nucleus Hs6912292 389.0 B [B] Chromatin structure and dynamics; Q92729 Receptor-type tyrosine-protein phosphatase U OS=Homo sapiens OX=9606 GN=PTPRU PE=1 SV=2 - [PTPRU_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0008104;GO:0006470;GO:0007165;GO:0007166;GO:0007167;GO:0051716;GO:0070727;GO:0048869;GO:0048513;GO:0048519;GO:0033036;GO:0042127;GO:0031100;GO:0031960;GO:0010033;GO:0044700;GO:0044707;GO:0048870;GO:0019538;GO:0016055;GO:0006928;GO:0051674;GO:0035335;GO:0050789;GO:0044267;GO:0044260;GO:0065007;GO:0014070;GO:0016477;GO:0007185;GO:0098602;GO:0098609;GO:0050794;GO:0060070;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0050896;GO:2000145;GO:2000146;GO:0016311;GO:0030154;GO:0023052;GO:0042221;GO:0044699;GO:0009719;GO:0031099;GO:0034394;GO:0022610;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0009987;GO:0051271;GO:0040012;GO:0032879;GO:0009725;GO:0043170;GO:0048731;GO:0048545;GO:0051384;GO:0016337;GO:0007275;GO:0033993;GO:0006796;GO:0071704;GO:0030336;GO:0030334;GO:0034109;GO:0034613;GO:0006464;GO:0044767;GO:0044763;GO:0007155;GO:0007154;GO:0051179;GO:0051641;GO:0040011;GO:0044238;GO:0040013;GO:0051270;GO:0048856;GO:0044237;GO:0006793;GO:0048523; protein localization;protein dephosphorylation;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;cellular response to stimulus;cellular macromolecule localization;cellular developmental process;animal organ development;negative regulation of biological process;macromolecule localization;regulation of cell proliferation;organ regeneration;response to corticosteroid;response to organic substance;single organism signaling;single-multicellular organism process;cell motility;protein metabolic process;Wnt signaling pathway;movement of cell or subcellular component;localization of cell;peptidyl-tyrosine dephosphorylation;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;response to organic cyclic compound;cell migration;transmembrane receptor protein tyrosine phosphatase signaling pathway;single organism cell adhesion;cell-cell adhesion;regulation of cellular process;canonical Wnt signaling pathway;macromolecule modification;protein modification process;biological_process;metabolic process;response to stimulus;regulation of cell motility;negative regulation of cell motility;dephosphorylation;cell differentiation;signaling;response to chemical;single-organism process;response to endogenous stimulus;regeneration;protein localization to cell surface;biological adhesion;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;cellular process;negative regulation of cellular component movement;regulation of locomotion;regulation of localization;response to hormone;macromolecule metabolic process;system development;response to steroid hormone;response to glucocorticoid;single organismal cell-cell adhesion;multicellular organism development;response to lipid;phosphate-containing compound metabolic process;organic substance metabolic process;negative regulation of cell migration;regulation of cell migration;homotypic cell-cell adhesion;cellular protein localization;cellular protein modification process;single-organism developmental process;single-organism cellular process;cell adhesion;cell communication;localization;cellular localization;locomotion;primary metabolic process;negative regulation of locomotion;regulation of cellular component movement;anatomical structure development;cellular metabolic process;phosphorus metabolic process;negative regulation of cellular process; 4;7;4;5;6;3;4;4;4;2;3;4;5;6;4;3;3;3;4;6;4;3;8;2;5;4;2;5;4;7;3;4;3;7;5;5;1;2;2;4;4;6;5;2;3;2;3;4;6;2;2;4;2;3;2;4;3;3;4;4;4;5;7;4;4;5;5;3;5;5;5;5;6;3;3;3;4;2;3;2;3;3;4;3;3;4;3; GO:0031224;GO:0030054;GO:0016021;GO:0016020;GO:0044425;GO:0031226;GO:0044459;GO:0005911;GO:0044464;GO:0005623;GO:0071944;GO:0005887;GO:0005886;GO:0005575; intrinsic component of membrane;cell junction;integral component of membrane;membrane;membrane part;intrinsic component of plasma membrane;plasma membrane part;cell-cell junction;cell part;cell;cell periphery;integral component of plasma membrane;plasma membrane;cellular_component; 3;2;4;2;2;4;3;3;2;2;3;4;3;1; GO:0060089;GO:0099600;GO:0003674;GO:0005488;GO:0016787;GO:0016788;GO:0008013;GO:0003824;GO:0004721;GO:0005001;GO:0016791;GO:0042578;GO:0038023;GO:0005515;GO:0004725;GO:0004872;GO:0004871;GO:0004888;GO:0019198; molecular transducer activity;transmembrane receptor activity;molecular_function;binding;hydrolase activity;hydrolase activity, acting on ester bonds;beta-catenin binding;catalytic activity;phosphoprotein phosphatase activity;transmembrane receptor protein tyrosine phosphatase activity;phosphatase activity;phosphoric ester hydrolase activity;signaling receptor activity;protein binding;protein tyrosine phosphatase activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity;transmembrane receptor protein phosphatase activity; 2;4;1;2;3;4;4;2;7;6;6;5;3;3;8;3;2;4;5; K16662 IPR016130;IPR013783;IPR000998;IPR007110;IPR029021;IPR003961;IPR003595;IPR013320;IPR000387;IPR000242; Protein-tyrosine phosphatase, active site;Immunoglobulin-like fold;MAM domain;Immunoglobulin-like domain;Protein-tyrosine phosphatase-like;Fibronectin type III;Protein-tyrosine phosphatase, catalytic;Concanavalin A-like lectin/glucanase domain;Tyrosine specific protein phosphatases domain;PTP type protein phosphatase; extracellular Hs19743935 3014.0 T [T] Signal transduction mechanisms; B3EWG6 Protein FAM25G OS=Homo sapiens OX=9606 GN=FAM25G PE=3 SV=1 - [FM25G_HUMAN] 0.979 1.008 0.759 1.843 0.878 0.793 0.971230159 nan 2.099088838 nan 0.75297619 nan 0.903189066 nan IPR023243; FAM25; cytosol Q9UBC5 Unconventional myosin-Ia OS=Homo sapiens OX=9606 GN=MYO1A PE=1 SV=1 - [MYO1A_HUMAN] 0.979 1.138 0.981 1.167 1.074 0.639 0.860281195 nan 1.086592179 nan 0.862038664 nan 0.594972067 nan GO:0008104;GO:0071840;GO:0007605;GO:0007600;GO:0003008;GO:0022607;GO:0016043;GO:0065007;GO:0050954;GO:0008150;GO:0044699;GO:0032880;GO:0032501;GO:0050877;GO:0009987;GO:0032879;GO:0033036;GO:0030030;GO:0030031;GO:0030033;GO:0050789;GO:0032528;GO:0044763;GO:0051648;GO:0051179;GO:0051640;GO:0051641;GO:0044085; protein localization;cellular component organization or biogenesis;sensory perception of sound;sensory perception;system process;cellular component assembly;cellular component organization;biological regulation;sensory perception of mechanical stimulus;biological_process;single-organism process;regulation of protein localization;multicellular organismal process;neurological system process;cellular process;regulation of localization;macromolecule localization;cell projection organization;cell projection assembly;microvillus assembly;regulation of biological process;microvillus organization;single-organism cellular process;vesicle localization;localization;organelle localization;cellular localization;cellular component biogenesis; 4;2;7;5;3;4;3;2;6;1;2;4;2;4;2;3;3;4;5;6;2;5;3;5;2;4;3;3; GO:0099512;GO:0099513;GO:0030427;GO:0030426;GO:0044853;GO:0016020;GO:0016459;GO:0098862;GO:0098589;GO:0044297;GO:0036477;GO:0042995;GO:0043234;GO:0043232;GO:0098858;GO:0044424;GO:0044425;GO:0098857;GO:0044422;GO:0098590;GO:0043229;GO:0043228;GO:0043226;GO:0005856;GO:0044430;GO:0043025;GO:0031941;GO:0031252;GO:0005938;GO:0030863;GO:0030864;GO:0044446;GO:0044444;GO:0044448;GO:0005902;GO:0005903;GO:0005737;GO:0045177;GO:0045178;GO:0043005;GO:0009925;GO:0044459;GO:0016328;GO:0016324;GO:0016323;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0015629;GO:0071944;GO:0098805;GO:0097458;GO:0099568;GO:0005884;GO:0005886;GO:0032991;GO:0045121;GO:0005575; supramolecular fiber;polymeric cytoskeletal fiber;site of polarized growth;growth cone;plasma membrane raft;membrane;myosin complex;cluster of actin-based cell projections;membrane region;cell body;somatodendritic compartment;cell projection;protein complex;intracellular non-membrane-bounded organelle;actin-based cell projection;intracellular part;membrane part;membrane microdomain;organelle part;plasma membrane region;intracellular organelle;non-membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;neuronal cell body;filamentous actin;cell leading edge;cell cortex;cortical cytoskeleton;cortical actin cytoskeleton;intracellular organelle part;cytoplasmic part;cell cortex part;microvillus;brush border;cytoplasm;apical part of cell;basal part of cell;neuron projection;basal plasma membrane;plasma membrane part;lateral plasma membrane;apical plasma membrane;basolateral plasma membrane;cell projection part;cell part;cell;intracellular;actin cytoskeleton;cell periphery;whole membrane;neuron part;cytoplasmic region;actin filament;plasma membrane;macromolecular complex;membrane raft;cellular_component; 2;3;3;4;4;2;4;3;3;3;4;3;3;4;4;3;2;4;2;4;3;3;2;5;4;4;4;3;4;6;5;3;4;5;5;4;4;3;3;4;4;3;4;4;4;3;2;2;3;6;3;3;3;5;4;3;2;5;1; GO:1901363;GO:0000166;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0003774;GO:0005524;GO:0016787;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0035639;GO:0043167;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0036094;GO:0043168;GO:0032553; heterocyclic compound binding;nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;motor activity;ATP binding;hydrolase activity;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;anion binding;ribonucleotide binding; 3;4;5;3;4;1;2;4;5;5;8;6;3;2;3;6;6;5;6;5;3;6;5;4;7;3;4;4; K10356 IPR001609;IPR000048;IPR027417;IPR010926; Myosin head, motor domain;IQ motif, EF-hand binding site;P-loop containing nucleoside triphosphate hydrolase;Class I myosin tail homology domain; cytosol Hs4885503 2158.0 Z [Z] Cytoskeleton; P35908 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 - [K22E_HUMAN] 0.735 0.714 1.758 0.873 0.984 1.097 1.029411765 0.78681186 0.887195122 0.887177317 2.462184874 0.000520067 1.114837398 0.101330971 GO:0044707;GO:0048856;GO:0060429;GO:0030154;GO:0006928;GO:0050673;GO:0001667;GO:0008544;GO:0044699;GO:0010631;GO:0051546;GO:0032980;GO:0048869;GO:0007275;GO:0048513;GO:0030855;GO:0016477;GO:0043588;GO:0032502;GO:0090130;GO:0032501;GO:0030216;GO:0008283;GO:0009987;GO:0009888;GO:0051674;GO:0044767;GO:0001775;GO:0008150;GO:0048731;GO:0051179;GO:0043616;GO:0090132;GO:0040011;GO:0048870;GO:0031424;GO:0009913;GO:0044763; single-multicellular organism process;anatomical structure development;epithelium development;cell differentiation;movement of cell or subcellular component;epithelial cell proliferation;ameboidal-type cell migration;epidermis development;single-organism process;epithelial cell migration;keratinocyte migration;keratinocyte activation;cellular developmental process;multicellular organism development;animal organ development;epithelial cell differentiation;cell migration;skin development;developmental process;tissue migration;multicellular organismal process;keratinocyte differentiation;cell proliferation;cellular process;tissue development;localization of cell;single-organism developmental process;cell activation;biological_process;system development;localization;keratinocyte proliferation;epithelium migration;locomotion;cell motility;keratinization;epidermal cell differentiation;single-organism cellular process; 3;3;5;5;4;4;5;6;2;6;7;5;4;4;4;6;4;5;2;4;2;6;3;2;4;3;3;4;1;4;2;5;5;2;3;4;7;3; GO:0099512;GO:0099513;GO:0045095;GO:0043229;GO:0043228;GO:0044430;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0045111;GO:0070062;GO:0005634;GO:0016020;GO:0005615;GO:0005794;GO:0005882;GO:0012505;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0043232;GO:0005856;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421;GO:0044422; supramolecular fiber;polymeric cytoskeletal fiber;keratin filament;intracellular organelle;non-membrane-bounded organelle;cytoskeletal part;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;intermediate filament cytoskeleton;extracellular exosome;nucleus;membrane;extracellular space;Golgi apparatus;intermediate filament;endomembrane system;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytoskeleton;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part;organelle part; 2;3;5;3;3;4;3;2;4;3;6;4;5;2;3;4;4;3;3;4;3;4;4;5;2;2;3;1;4;2;3;2;2; GO:0003674;GO:0005198;GO:0005200; molecular_function;structural molecule activity;structural constituent of cytoskeleton; 1;2;3; K07605 IPR003054;IPR001664;IPR032444;IPR018039; Keratin, type II;Intermediate filament protein;Keratin type II head;Intermediate filament protein, conserved site; nucleus Q13939 Calicin OS=Homo sapiens OX=9606 GN=CCIN PE=2 SV=3 - [CALI_HUMAN] 1.258 0.791 1.316 1.001 0.815 0.707 1.590391909 nan 1.228220859 nan 1.663716814 nan 0.867484663 nan GO:0044707;GO:0030154;GO:0019953;GO:0044237;GO:0043170;GO:0044699;GO:0000003;GO:0044260;GO:0032446;GO:0048869;GO:0070647;GO:0007275;GO:0071704;GO:0007276;GO:0032502;GO:0032501;GO:0048609;GO:0032504;GO:0044267;GO:0009987;GO:0006464;GO:0044767;GO:0022414;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0048232;GO:0051704;GO:0044238;GO:0044703;GO:0044702;GO:0019538;GO:0048856;GO:0007283;GO:0016567;GO:0044763; single-multicellular organism process;cell differentiation;sexual reproduction;cellular metabolic process;macromolecule metabolic process;single-organism process;reproduction;cellular macromolecule metabolic process;protein modification by small protein conjugation;cellular developmental process;protein modification by small protein conjugation or removal;multicellular organism development;organic substance metabolic process;gamete generation;developmental process;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cellular protein metabolic process;cellular process;cellular protein modification process;single-organism developmental process;reproductive process;macromolecule modification;protein modification process;biological_process;metabolic process;male gamete generation;multi-organism process;primary metabolic process;multi-organism reproductive process;single organism reproductive process;protein metabolic process;anatomical structure development;spermatogenesis;protein ubiquitination;single-organism cellular process; 3;5;3;3;4;2;2;4;8;4;7;4;3;4;2;2;3;3;5;2;6;3;2;5;5;1;2;5;2;3;3;3;4;3;6;9;3; GO:1990234;GO:0033150;GO:0000151;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:1902494;GO:0005856;GO:0005575;GO:0005634;GO:0044430;GO:0033011;GO:0048471;GO:0005737;GO:0031461;GO:0031463;GO:0043234;GO:0032991;GO:0043231;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0044444;GO:0044424;GO:0044422; transferase complex;cytoskeletal calyx;ubiquitin ligase complex;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;catalytic complex;cytoskeleton;cellular_component;nucleus;cytoskeletal part;perinuclear theca;perinuclear region of cytoplasm;cytoplasm;cullin-RING ubiquitin ligase complex;Cul3-RING ubiquitin ligase complex;protein complex;macromolecular complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;intracellular organelle part;cytoplasmic part;intracellular part;organelle part; 5;5;4;3;3;3;2;4;5;1;5;4;5;5;4;5;6;3;2;4;4;2;2;3;3;4;3;2; IPR011333;IPR011705;IPR017096;IPR000210;IPR015915;IPR006652; SKP1/BTB/POZ domain;BTB/Kelch-associated;BTB-kelch protein;BTB/POZ domain;Kelch-type beta propeller;Kelch repeat type 1; nucleus Hs17738312 1226.0 TR [T] Signal transduction mechanisms;[R] General function prediction only; P53708 Integrin alpha-8 OS=Homo sapiens OX=9606 GN=ITGA8 PE=1 SV=3 - [ITA8_HUMAN] 1.027 0.801 1.417 0.935 0.863 0.965 1.282147316 0.174734788 1.083429896 0.096873149 1.769038702 0.011016434 1.118192352 0.131536912 GO:0008104;GO:0017015;GO:0019222;GO:0034446;GO:0048584;GO:0048468;GO:0007613;GO:0007610;GO:0007611;GO:0007160;GO:0060322;GO:0007165;GO:0007166;GO:0007167;GO:0090287;GO:1901362;GO:0071840;GO:0051716;GO:0071704;GO:0009966;GO:0048869;GO:0001822;GO:0048513;GO:0030511;GO:0048518;GO:2000721;GO:0031589;GO:0044700;GO:0060255;GO:0048583;GO:0007178;GO:0045184;GO:0023052;GO:2001141;GO:0010033;GO:0007179;GO:0003008;GO:0044707;GO:0009790;GO:0044708;GO:0071310;GO:0050789;GO:0007154;GO:0030198;GO:0042692;GO:0051252;GO:0009893;GO:0009891;GO:0048568;GO:0006807;GO:0097659;GO:1901576;GO:0000904;GO:0000902;GO:0044260;GO:0010646;GO:0046483;GO:0016043;GO:0070887;GO:0065007;GO:0045893;GO:0006366;GO:0048646;GO:0018130;GO:0009719;GO:0009887;GO:0098602;GO:0048745;GO:0006139;GO:0098609;GO:0050794;GO:0008150;GO:0008152;GO:0019438;GO:0034654;GO:0051234;GO:0010604;GO:0016070;GO:0044271;GO:0007420;GO:0007423;GO:0050896;GO:0050890;GO:0006355;GO:0010556;GO:0006351;GO:0009967;GO:0009889;GO:0007369;GO:0032774;GO:0007498;GO:0030154;GO:0070848;GO:0023056;GO:0044249;GO:0034641;GO:0048562;GO:1901360;GO:0034645;GO:0023051;GO:0061061;GO:0010647;GO:0009653;GO:0044699;GO:0007417;GO:0001707;GO:0001704;GO:0022610;GO:0032502;GO:0032501;GO:0048332;GO:0048333;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:0001655;GO:0001656;GO:0072001;GO:0048839;GO:0033036;GO:0071363;GO:0007399;GO:0051254;GO:1902680;GO:0071560;GO:0010628;GO:0045944;GO:0048731;GO:0007229;GO:1903508;GO:0016337;GO:0031328;GO:0030030;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0043170;GO:0051145;GO:0007275;GO:0009888;GO:1903844;GO:1903846;GO:0071559;GO:2000112;GO:0010557;GO:0032989;GO:0010467;GO:0006357;GO:0043583;GO:0048729;GO:0043062;GO:0010468;GO:0090596;GO:0048598;GO:0090092;GO:0045935;GO:0019219;GO:0080090;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0007155;GO:0042221;GO:0051179;GO:0042471;GO:0044238;GO:0042472;GO:0090100;GO:0051173;GO:0048856;GO:0044237;GO:0071495;GO:0060537;GO:0048522; protein localization;regulation of transforming growth factor beta receptor signaling pathway;regulation of metabolic process;substrate adhesion-dependent cell spreading;positive regulation of response to stimulus;cell development;memory;behavior;learning or memory;cell-matrix adhesion;head development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of cellular response to growth factor stimulus;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular response to stimulus;organic substance metabolic process;regulation of signal transduction;cellular developmental process;kidney development;animal organ development;positive regulation of transforming growth factor beta receptor signaling pathway;positive regulation of biological process;positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation;cell-substrate adhesion;single organism signaling;regulation of macromolecule metabolic process;regulation of response to stimulus;transmembrane receptor protein serine/threonine kinase signaling pathway;establishment of protein localization;signaling;regulation of RNA biosynthetic process;response to organic substance;transforming growth factor beta receptor signaling pathway;system process;single-multicellular organism process;embryo development;single-organism behavior;cellular response to organic substance;regulation of biological process;cell communication;extracellular matrix organization;muscle cell differentiation;regulation of RNA metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;embryonic organ development;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;regulation of cell communication;heterocycle metabolic process;cellular component organization;cellular response to chemical stimulus;biological regulation;positive regulation of transcription, DNA-templated;transcription from RNA polymerase II promoter;anatomical structure formation involved in morphogenesis;heterocycle biosynthetic process;response to endogenous stimulus;organ morphogenesis;single organism cell adhesion;smooth muscle tissue development;nucleobase-containing compound metabolic process;cell-cell adhesion;regulation of cellular process;biological_process;metabolic process;aromatic compound biosynthetic process;nucleobase-containing compound biosynthetic process;establishment of localization;positive regulation of macromolecule metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;brain development;sensory organ development;response to stimulus;cognition;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of signal transduction;regulation of biosynthetic process;gastrulation;RNA biosynthetic process;mesoderm development;cell differentiation;response to growth factor;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryonic organ morphogenesis;organic cyclic compound metabolic process;cellular macromolecule biosynthetic process;regulation of signaling;muscle structure development;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;central nervous system development;mesoderm formation;formation of primary germ layer;biological adhesion;developmental process;multicellular organismal process;mesoderm morphogenesis;mesodermal cell differentiation;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;urogenital system development;metanephros development;renal system development;inner ear development;macromolecule localization;cellular response to growth factor stimulus;nervous system development;positive regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;cellular response to transforming growth factor beta stimulus;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;system development;integrin-mediated signaling pathway;positive regulation of nucleic acid-templated transcription;single organismal cell-cell adhesion;positive regulation of cellular biosynthetic process;cell projection organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;macromolecule metabolic process;smooth muscle cell differentiation;multicellular organism development;tissue development;regulation of cellular response to transforming growth factor beta stimulus;positive regulation of cellular response to transforming growth factor beta stimulus;response to transforming growth factor beta;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;cellular component morphogenesis;gene expression;regulation of transcription from RNA polymerase II promoter;ear development;tissue morphogenesis;extracellular structure organization;regulation of gene expression;sensory organ morphogenesis;embryonic morphogenesis;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of primary metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;cell adhesion;response to chemical;localization;ear morphogenesis;primary metabolic process;inner ear morphogenesis;positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;positive regulation of nitrogen compound metabolic process;anatomical structure development;cellular metabolic process;cellular response to endogenous stimulus;muscle tissue development;positive regulation of cellular process; 4;6;3;4;3;4;5;2;4;5;4;4;5;6;4;5;2;3;3;4;4;4;4;5;2;7;4;3;4;3;7;4;2;6;4;6;3;3;5;3;5;2;4;5;5;5;3;4;4;3;7;4;5;5;4;4;4;3;4;2;6;7;3;5;3;4;3;6;4;4;3;1;2;5;5;3;4;5;5;4;4;2;5;6;5;6;4;4;5;6;5;5;5;3;4;4;5;4;5;3;4;4;3;2;5;5;4;2;2;2;5;6;4;2;4;7;5;5;5;4;3;6;5;5;6;5;5;7;4;6;7;4;5;4;5;4;4;5;4;6;4;4;5;4;4;6;5;4;5;7;5;4;4;5;5;4;5;5;5;4;3;3;5;3;4;3;3;2;6;3;5;5;4;3;3;4;5;3; GO:0005783;GO:0098802;GO:0031224;GO:0043228;GO:0030055;GO:0097060;GO:0043204;GO:0016021;GO:0016020;GO:0098589;GO:0044297;GO:0060076;GO:0034678;GO:0036477;GO:0042995;GO:0043234;GO:0043235;GO:0043231;GO:0044424;GO:0044425;GO:0098590;GO:0043232;GO:0043229;GO:0005924;GO:0005925;GO:0043227;GO:0043226;GO:0030054;GO:0043025;GO:0031256;GO:0070161;GO:0031253;GO:0031252;GO:0008305;GO:0012505;GO:0044444;GO:0098636;GO:0031226;GO:0005737;GO:0045177;GO:0044456;GO:0043005;GO:0044459;GO:0009986;GO:0032589;GO:0014069;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0099572;GO:0071944;GO:0045202;GO:0032591;GO:0032590;GO:0098797;GO:0098805;GO:0097458;GO:0005887;GO:0005886;GO:0032991;GO:0005575;GO:0098796;GO:0098794;GO:0005912; endoplasmic reticulum;plasma membrane receptor complex;intrinsic component of membrane;non-membrane-bounded organelle;cell-substrate junction;synaptic membrane;perikaryon;integral component of membrane;membrane;membrane region;cell body;excitatory synapse;integrin alpha8-beta1 complex;somatodendritic compartment;cell projection;protein complex;receptor complex;intracellular membrane-bounded organelle;intracellular part;membrane part;plasma membrane region;intracellular non-membrane-bounded organelle;intracellular organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;organelle;cell junction;neuronal cell body;leading edge membrane;anchoring junction;cell projection membrane;cell leading edge;integrin complex;endomembrane system;cytoplasmic part;protein complex involved in cell adhesion;intrinsic component of plasma membrane;cytoplasm;apical part of cell;synapse part;neuron projection;plasma membrane part;cell surface;neuron projection membrane;postsynaptic density;cell projection part;cell part;cell;intracellular;postsynaptic specialization;cell periphery;synapse;dendritic spine membrane;dendrite membrane;plasma membrane protein complex;whole membrane;neuron part;integral component of plasma membrane;plasma membrane;macromolecular complex;cellular_component;membrane protein complex;postsynapse;adherens junction; 4;4;3;3;3;3;4;4;2;3;3;3;6;4;3;3;4;4;3;2;4;4;3;4;5;3;2;2;4;4;3;4;3;5;3;4;4;4;4;3;2;4;3;3;4;4;3;2;2;3;3;3;2;4;5;4;3;3;4;3;2;1;3;3;4; GO:0046872;GO:0003674;GO:0005488;GO:0043169;GO:0043167; metal ion binding;molecular_function;binding;cation binding;ion binding; 5;1;2;4;3; K06584 map04151;map04510;map04512;map04514;map04810;map05410;map05412;map05414; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Cell adhesion molecules (CAMs);Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy; IPR013649;IPR013517;IPR018184;IPR000413;IPR032695;IPR013519; Integrin alpha-2;FG-GAP repeat;Integrin alpha chain, C-terminal cytoplasmic region, conserved site;Integrin alpha chain;Integrin domain;Integrin alpha beta-propellor; endoplasmic reticulum Hs20473650 1569.0 W [W] Extracellular structures; Q08211 ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4 - [DHX9_HUMAN] 0.688 0.97 1.4 0.856 0.965 1.758 0.709278351 0.089536107 0.887046632 0.031263504 1.443298969 0.009103477 1.821761658 0.032356627 GO:0008104;GO:0019222;GO:0001503;GO:0070934;GO:0071840;GO:0070727;GO:0010608;GO:0048511;GO:0048518;GO:0033036;GO:0032392;GO:0060255;GO:0046483;GO:0044707;GO:0000398;GO:0002376;GO:0071103;GO:0050789;GO:0044260;GO:0016043;GO:0065007;GO:1901360;GO:0065008;GO:0051240;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0050896;GO:0032481;GO:0051239;GO:0048869;GO:0001819;GO:0048255;GO:0030154;GO:0034641;GO:0044699;GO:0006139;GO:0043489;GO:0043488;GO:0043487;GO:0016071;GO:0008380;GO:0032502;GO:0016070;GO:0032501;GO:0032508;GO:0009987;GO:0006725;GO:0043170;GO:0001816;GO:0001817;GO:0006807;GO:0032479;GO:0033365;GO:0032606;GO:0090304;GO:0001649;GO:0071704;GO:0010467;GO:0010468;GO:0045087;GO:0034613;GO:0044767;GO:0000375;GO:0000377;GO:0044763;GO:1903608;GO:0051179;GO:0051641;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:0006396;GO:0006397; protein localization;regulation of metabolic process;ossification;CRD-mediated mRNA stabilization;cellular component organization or biogenesis;cellular macromolecule localization;posttranscriptional regulation of gene expression;rhythmic process;positive regulation of biological process;macromolecule localization;DNA geometric change;regulation of macromolecule metabolic process;heterocycle metabolic process;single-multicellular organism process;mRNA splicing, via spliceosome;immune system process;DNA conformation change;regulation of biological process;cellular macromolecule metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;regulation of biological quality;positive regulation of multicellular organismal process;defense response;response to stress;biological_process;metabolic process;immune response;response to stimulus;positive regulation of type I interferon production;regulation of multicellular organismal process;cellular developmental process;positive regulation of cytokine production;mRNA stabilization;cell differentiation;cellular nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;RNA stabilization;regulation of mRNA stability;regulation of RNA stability;mRNA metabolic process;RNA splicing;developmental process;RNA metabolic process;multicellular organismal process;DNA duplex unwinding;cellular process;cellular aromatic compound metabolic process;macromolecule metabolic process;cytokine production;regulation of cytokine production;nitrogen compound metabolic process;regulation of type I interferon production;protein localization to organelle;type I interferon production;nucleic acid metabolic process;osteoblast differentiation;organic substance metabolic process;gene expression;regulation of gene expression;innate immune response;cellular protein localization;single-organism developmental process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;single-organism cellular process;protein localization to cytoplasmic stress granule;localization;cellular localization;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;RNA processing;mRNA processing; 4;3;4;7;2;4;6;2;2;3;7;4;4;3;8;2;6;2;4;3;2;4;3;3;4;3;1;2;3;2;5;3;4;4;6;5;4;2;4;5;5;4;6;7;2;5;2;8;2;4;4;4;4;3;5;6;5;5;5;3;5;5;4;5;3;8;9;3;7;2;3;4;3;5;3;6;7; GO:0035770;GO:0031974;GO:0070937;GO:0030529;GO:0031981;GO:0016020;GO:0043234;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0044464;GO:0043232;GO:0043229;GO:0043228;GO:0036464;GO:0005622;GO:0043227;GO:0005856;GO:0097165;GO:0005654;GO:0044430;GO:0005730;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005815;GO:1990904;GO:0005623;GO:0005813;GO:0043226;GO:0015630;GO:0032991;GO:0005575;GO:0070013; ribonucleoprotein granule;membrane-enclosed lumen;CRD-mediated mRNA stability complex;intracellular ribonucleoprotein complex;nuclear lumen;membrane;protein complex;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;cell part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;cytoplasmic ribonucleoprotein granule;intracellular;membrane-bounded organelle;cytoskeleton;nuclear stress granule;nucleoplasm;cytoskeletal part;nucleolus;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;microtubule organizing center;ribonucleoprotein complex;cell;centrosome;organelle;microtubule cytoskeleton;macromolecular complex;cellular_component;intracellular organelle lumen; 5;2;4;4;5;2;3;4;3;5;4;3;2;2;4;3;3;5;3;3;5;5;5;4;5;3;4;4;5;5;3;2;5;2;6;2;1;4; GO:1901363;GO:0000166;GO:0008186;GO:0008134;GO:0004386;GO:0016818;GO:0097367;GO:0016817;GO:0070035;GO:0016787;GO:0003674;GO:0003676;GO:0003677;GO:0003678;GO:1901265;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0003824;GO:0001085;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0008026;GO:0035639;GO:0043167;GO:0008094;GO:0030554;GO:0003724;GO:0003723;GO:0005515;GO:0005488;GO:0016887;GO:0001882;GO:0001883;GO:0004003;GO:0044822;GO:0017111;GO:0004004; heterocyclic compound binding;nucleotide binding;RNA-dependent ATPase activity;transcription factor binding;helicase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;purine NTP-dependent helicase activity;hydrolase activity;molecular_function;nucleic acid binding;DNA binding;DNA helicase activity;nucleoside phosphate binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;catalytic activity;RNA polymerase II transcription factor binding;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ATP-dependent helicase activity;purine ribonucleoside triphosphate binding;ion binding;DNA-dependent ATPase activity;adenyl nucleotide binding;RNA helicase activity;RNA binding;protein binding;binding;ATPase activity;nucleoside binding;purine nucleoside binding;ATP-dependent DNA helicase activity;poly(A) RNA binding;nucleoside-triphosphatase activity;ATP-dependent RNA helicase activity; 3;4;10;4;8;5;3;4;9;3;1;4;5;9;4;9;5;5;6;4;2;5;3;3;6;6;5;6;4;10;5;3;10;6;9;5;3;2;8;4;5;10;6;7;10; K13184 IPR014720;IPR007502;IPR011545;IPR011709;IPR001650;IPR002464;IPR014001;IPR027417; Double-stranded RNA-binding domain;Helicase-associated domain;DEAD/DEAH box helicase domain;Domain of unknown function DUF1605;Helicase, C-terminal;DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site;Helicase superfamily 1/2, ATP-binding domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs4503297 2540.0 K [K] Transcription; Q9NTK1 Protein DEPP1 OS=Homo sapiens OX=9606 GN=DEPP1 PE=1 SV=2 - [DEPP1_HUMAN] 0.755 0.939 1.54 0.783 1.059 0.927 0.804046858 nan 0.739376771 nan 1.640042599 nan 0.875354108 nan GO:0005737;GO:0043231;GO:0044464;GO:0043229;GO:0005739;GO:0005622;GO:0005575;GO:0044444;GO:0005623;GO:0044424;GO:0043227;GO:0043226; cytoplasm;intracellular membrane-bounded organelle;cell part;intracellular organelle;mitochondrion;intracellular;cellular_component;cytoplasmic part;cell;intracellular part;membrane-bounded organelle;organelle; 4;4;2;3;5;3;1;4;2;3;3;2; IPR020133; Decidual protein, progesterone induced; mitochondria Q49MI3 Ceramide kinase-like protein OS=Homo sapiens OX=9606 GN=CERKL PE=1 SV=1 - [CERKL_HUMAN] 0.936 1.24 0.705 0.98 1.382 0.815 0.75483871 0.42341525 0.709117221 0.272426967 0.568548387 0.105312783 0.589725036 0.157177359 GO:0008219;GO:0010941;GO:0044699;GO:0042981;GO:0043067;GO:0050789;GO:0043066;GO:0065007;GO:0048519;GO:0043069;GO:0006915;GO:0060548;GO:0050794;GO:0008150;GO:0012501;GO:0048523;GO:0044763;GO:0009987; cell death;regulation of cell death;single-organism process;regulation of apoptotic process;regulation of programmed cell death;regulation of biological process;negative regulation of apoptotic process;biological regulation;negative regulation of biological process;negative regulation of programmed cell death;apoptotic process;negative regulation of cell death;regulation of cellular process;biological_process;programmed cell death;negative regulation of cellular process;single-organism cellular process;cellular process; 4;4;2;6;5;2;6;2;2;5;6;4;3;1;5;3;3;2; GO:0005783;GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0031981;GO:0005730;GO:0005634;GO:0005794;GO:0012505;GO:0043231;GO:0043232;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422; endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;nuclear lumen;nucleolus;nucleus;Golgi apparatus;endomembrane system;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part; 4;2;3;3;3;2;4;3;5;5;5;4;3;4;4;3;2;2;3;1;4;4;4;3;2; GO:0003674;GO:0016740;GO:0016301;GO:0003824;GO:0016772; molecular_function;transferase activity;kinase activity;catalytic activity;transferase activity, transferring phosphorus-containing groups; 1;3;5;2;4; K19602 IPR017438;IPR001206;IPR016064; Inorganic polyphosphate/ATP-NAD kinase, domain 1;Diacylglycerol kinase, catalytic domain;NAD kinase/diacylglycerol kinase-like domain; nucleus Hs20536226 498.0 IT [I] Lipid transport and metabolism;[T] Signal transduction mechanisms; O75443 Alpha-tectorin OS=Homo sapiens OX=9606 GN=TECTA PE=1 SV=3 - [TECTA_HUMAN] 0.952 0.939 1.278 0.861 1.06 0.744 1.013844515 0.759143744 0.812264151 0.007139978 1.361022364 0.000251985 0.701886792 0.008087648 GO:0007160;GO:0050877;GO:0022610;GO:0031589;GO:0032501;GO:0007605;GO:0050954;GO:0007600;GO:0008150;GO:0007155;GO:0003008; cell-matrix adhesion;neurological system process;biological adhesion;cell-substrate adhesion;multicellular organismal process;sensory perception of sound;sensory perception of mechanical stimulus;sensory perception;biological_process;cell adhesion;system process; 5;4;2;4;2;7;6;5;1;3;3; GO:0031012;GO:0071944;GO:0043227;GO:0043226;GO:0031224;GO:0031225;GO:0070062;GO:0016020;GO:0031982;GO:0005886;GO:1903561;GO:0043230;GO:0044464;GO:0005623;GO:0005578;GO:0005575;GO:0005576;GO:0044425;GO:0044421; extracellular matrix;cell periphery;membrane-bounded organelle;organelle;intrinsic component of membrane;anchored component of membrane;extracellular exosome;membrane;vesicle;plasma membrane;extracellular vesicle;extracellular organelle;cell part;cell;proteinaceous extracellular matrix;cellular_component;extracellular region;membrane part;extracellular region part; 2;3;3;2;3;4;4;2;4;3;3;3;2;2;3;1;2;2;2; GO:0005201;GO:0003674;GO:0005198; extracellular matrix structural constituent;molecular_function;structural molecule activity; 3;1;2; K18273 IPR002919;IPR000742;IPR003886;IPR017977;IPR001007;IPR014853;IPR025615;IPR001507;IPR001846;IPR033026; Trypsin Inhibitor-like, cysteine rich domain;EGF-like domain;NIDO domain;Zona pellucida domain, conserved site;VWFC domain;Uncharacterised domain, cysteine-rich;TILa domain;Zona pellucida domain;von Willebrand factor, type D domain;Alpha-tectorin; peroxisome Hs4885627_2 3103.0 WV [W] Extracellular structures;[V] Defense mechanisms; Q9UJT0 Tubulin epsilon chain OS=Homo sapiens OX=9606 GN=TUBE1 PE=2 SV=1 - [TBE_HUMAN] 0.973 1.059 1.098 0.999 1.113 0.704 0.918791313 0.213333817 0.897574124 0.6711001 1.036827195 0.179810272 0.632524708 0.071157059 GO:0044699;GO:0031023;GO:0007049;GO:0071840;GO:1902589;GO:0016043;GO:0044763;GO:0051297;GO:0009987;GO:0008150;GO:0006996;GO:0007017;GO:0007010;GO:0022402;GO:0007098;GO:0000226; single-organism process;microtubule organizing center organization;cell cycle;cellular component organization or biogenesis;single-organism organelle organization;cellular component organization;single-organism cellular process;centrosome organization;cellular process;biological_process;organelle organization;microtubule-based process;cytoskeleton organization;cell cycle process;centrosome cycle;microtubule cytoskeleton organization; 2;5;4;2;4;3;3;6;2;1;4;4;5;4;5;5; GO:0000242;GO:0099512;GO:0099513;GO:0043229;GO:0043228;GO:0005874;GO:0043226;GO:0005856;GO:0044446;GO:0005813;GO:0005815;GO:0044430;GO:0044450;GO:0005737;GO:0015630;GO:0043232;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422; pericentriolar material;supramolecular fiber;polymeric cytoskeletal fiber;intracellular organelle;non-membrane-bounded organelle;microtubule;organelle;cytoskeleton;intracellular organelle part;centrosome;microtubule organizing center;cytoskeletal part;microtubule organizing center part;cytoplasm;microtubule cytoskeleton;intracellular non-membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part; 6;2;3;3;3;4;2;5;3;5;5;4;5;4;6;4;2;2;3;1;4;3;2; GO:0005200;GO:0016787;GO:0035639;GO:1901363;GO:0003674;GO:0005488;GO:0001883;GO:0005198;GO:0001882;GO:0019001;GO:0032561;GO:0032549;GO:0017076;GO:0005525;GO:0000166;GO:0003924;GO:0017111;GO:1901265;GO:0036094;GO:0003824;GO:0032555;GO:0016818;GO:0043167;GO:0097367;GO:0097159;GO:0016817;GO:0016462;GO:0032550;GO:0032553;GO:0043168; structural constituent of cytoskeleton;hydrolase activity;purine ribonucleoside triphosphate binding;heterocyclic compound binding;molecular_function;binding;purine nucleoside binding;structural molecule activity;nucleoside binding;guanyl nucleotide binding;guanyl ribonucleotide binding;ribonucleoside binding;purine nucleotide binding;GTP binding;nucleotide binding;GTPase activity;nucleoside-triphosphatase activity;nucleoside phosphate binding;small molecule binding;catalytic activity;purine ribonucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;ion binding;carbohydrate derivative binding;organic cyclic compound binding;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;purine ribonucleoside binding;ribonucleotide binding;anion binding; 3;3;5;3;1;2;5;2;4;6;6;5;5;6;4;8;7;4;3;2;5;5;3;3;3;4;6;6;4;4; K10391 IPR008280;IPR000217;IPR018316;IPR017975;IPR004057;IPR003008; Tubulin/FtsZ, C-terminal;Tubulin;Tubulin/FtsZ, 2-layer sandwich domain;Tubulin, conserved site;Epsilon tubulin;Tubulin/FtsZ, GTPase domain; cytoskeleton Hs7705915 988.0 Z [Z] Cytoskeleton; Q9UBU9 Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1 - [NXF1_HUMAN] 1.002 0.76 1.534 0.952 0.908 0.674 1.318421053 nan 1.04845815 nan 2.018421053 nan 0.742290749 nan GO:0015931;GO:0051169;GO:0071166;GO:0071426;GO:0051168;GO:0044419;GO:0051028;GO:0043170;GO:0044699;GO:0016973;GO:0006403;GO:0071704;GO:0010467;GO:0071702;GO:0051704;GO:0071705;GO:0006405;GO:0006406;GO:0009987;GO:0006810;GO:0006913;GO:0044765;GO:0044764;GO:0008150;GO:0008152;GO:0051649;GO:0051236;GO:0044403;GO:0051234;GO:0051179;GO:1902578;GO:0051641;GO:0050658;GO:0033036;GO:0046907;GO:0071427;GO:0050657;GO:0016032;GO:1902582; nucleobase-containing compound transport;nuclear transport;ribonucleoprotein complex localization;ribonucleoprotein complex export from nucleus;nuclear export;interspecies interaction between organisms;mRNA transport;macromolecule metabolic process;single-organism process;poly(A)+ mRNA export from nucleus;RNA localization;organic substance metabolic process;gene expression;organic substance transport;multi-organism process;nitrogen compound transport;RNA export from nucleus;mRNA export from nucleus;cellular process;transport;nucleocytoplasmic transport;single-organism transport;multi-organism cellular process;biological_process;metabolic process;establishment of localization in cell;establishment of RNA localization;symbiosis, encompassing mutualism through parasitism;establishment of localization;localization;single-organism localization;cellular localization;RNA transport;macromolecule localization;intracellular transport;mRNA-containing ribonucleoprotein complex export from nucleus;nucleic acid transport;viral process;single-organism intracellular transport; 6;6;4;5;8;3;6;4;2;6;4;3;5;5;2;5;6;6;2;4;7;4;3;1;2;4;4;4;3;2;3;3;5;3;5;6;7;4;5; GO:0016234;GO:0031974;GO:0031975;GO:0043229;GO:0043227;GO:0043226;GO:0016607;GO:0005575;GO:0016604;GO:0031981;GO:0005634;GO:0005635;GO:0005654;GO:0044451;GO:0005737;GO:0031967;GO:0012505;GO:0043231;GO:0043233;GO:0005643;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422;GO:0042405; inclusion body;membrane-enclosed lumen;envelope;intracellular organelle;membrane-bounded organelle;organelle;nuclear speck;cellular_component;nuclear body;nuclear lumen;nucleus;nuclear envelope;nucleoplasm;nucleoplasm part;cytoplasm;organelle envelope;endomembrane system;intracellular membrane-bounded organelle;organelle lumen;nuclear pore;cytosol;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part;nuclear inclusion body; 4;2;3;3;3;2;7;1;6;5;5;4;5;5;4;4;3;4;3;5;5;2;2;3;3;4;4;4;3;2;5; GO:0003674;GO:0005488;GO:0003676;GO:0003727;GO:0005215;GO:1901363;GO:1901265;GO:0000166;GO:0044822;GO:0036094;GO:0005487;GO:0097159;GO:0003723;GO:0003729; molecular_function;binding;nucleic acid binding;single-stranded RNA binding;transporter activity;heterocyclic compound binding;nucleoside phosphate binding;nucleotide binding;poly(A) RNA binding;small molecule binding;nucleocytoplasmic transporter activity;organic cyclic compound binding;RNA binding;mRNA binding; 1;2;4;6;2;3;4;4;6;3;3;3;5;7; K14284 map03008;map03013;map03015;map05164;map05168; Ribosome biogenesis in eukaryotes;RNA transport;mRNA surveillance pathway;Influenza A;Herpes simplex infection; IPR015245;IPR001611;IPR009060;IPR032710;IPR018222;IPR032675;IPR030217;IPR002075;IPR005637;IPR000504; Nuclear RNA export factor Tap, RNA-binding domain;Leucine-rich repeat;UBA-like;NTF2-like domain;Nuclear transport factor 2, eukaryote;Leucine-rich repeat domain, L domain-like;Nuclear RNA export factor;Nuclear transport factor 2;TAP C-terminal (TAP-C) domain;RNA recognition motif domain; nucleus Hs15487670 1286.0 A [A] RNA processing and modification; P05114 Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3 - [HMGN1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0051716;GO:0010604;GO:0048518;GO:0006283;GO:0006281;GO:0060255;GO:0032784;GO:0032786;GO:0006289;GO:2001141;GO:0046483;GO:0033554;GO:0019438;GO:0009893;GO:0009891;GO:0006807;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0018130;GO:0009889;GO:0044710;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0050896;GO:0006354;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:1903508;GO:0009987;GO:0006725;GO:1903506;GO:0006974;GO:0045893;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045935;GO:0019219;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044238;GO:0044237;GO:0006259;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;positive regulation of macromolecule metabolic process;positive regulation of biological process;transcription-coupled nucleotide-excision repair;DNA repair;regulation of macromolecule metabolic process;regulation of DNA-templated transcription, elongation;positive regulation of DNA-templated transcription, elongation;nucleotide-excision repair;regulation of RNA biosynthetic process;heterocycle metabolic process;cellular response to stress;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;heterocycle biosynthetic process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;response to stress;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;DNA-templated transcription, elongation;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;positive regulation of nucleic acid-templated transcription;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;positive regulation of transcription, DNA-templated;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;DNA metabolic process;positive regulation of cellular process; 4;3;5;4;3;4;2;6;4;4;7;7;5;6;4;4;5;3;4;3;7;4;4;2;5;4;3;3;3;1;2;5;5;5;2;7;6;5;5;6;6;4;4;5;2;4;7;2;4;7;5;6;5;5;4;6;5;5;5;4;4;5;6;2;3;5;5;5;5;3;5;3;4;4;3;3;5;3; GO:0031974;GO:0043228;GO:0031981;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0000785;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0044446;GO:0005694;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;non-membrane-bounded organelle;nuclear lumen;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;chromatin;intracellular;membrane-bounded organelle;organelle;nucleoplasm;cytoplasm;nucleus;cell part;cell;intracellular organelle part;chromosome;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;5;4;4;3;4;3;4;2;3;3;3;3;2;5;4;5;2;2;3;5;2;1;4; GO:1901363;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0003674; heterocyclic compound binding;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;molecular_function; 3;2;4;5;3;1; K11299 map05168; Herpes simplex infection; IPR000079; High mobility group protein HMGN; nucleus Q9NZM1 Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1 - [MYOF_HUMAN] 0.865 1.41 0.852 0.886 1.287 0.747 0.613475177 nan 0.688422688 nan 0.604255319 nan 0.58041958 nan GO:0034605;GO:0048583;GO:0061024;GO:0003012;GO:0003013;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0051716;GO:0010256;GO:0070848;GO:0006936;GO:0042221;GO:0010033;GO:0003008;GO:0044700;GO:0007009;GO:0033554;GO:0050789;GO:0016043;GO:0065007;GO:0044699;GO:0008015;GO:0042060;GO:0050794;GO:0006950;GO:0008150;GO:0009266;GO:0048010;GO:0001778;GO:0030947;GO:0050896;GO:0009966;GO:0044802;GO:0009611;GO:0023052;GO:0070887;GO:0023051;GO:0010646;GO:0090287;GO:0032501;GO:0009987;GO:0009408;GO:0071363;GO:0071310;GO:0044763;GO:0007154;GO:0009628; cellular response to heat;regulation of response to stimulus;membrane organization;muscle system process;circulatory system process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;endomembrane system organization;response to growth factor;muscle contraction;response to chemical;response to organic substance;system process;single organism signaling;plasma membrane organization;cellular response to stress;regulation of biological process;cellular component organization;biological regulation;single-organism process;blood circulation;wound healing;regulation of cellular process;response to stress;biological_process;response to temperature stimulus;vascular endothelial growth factor receptor signaling pathway;plasma membrane repair;regulation of vascular endothelial growth factor receptor signaling pathway;response to stimulus;regulation of signal transduction;single-organism membrane organization;response to wounding;signaling;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;regulation of cellular response to growth factor stimulus;multicellular organismal process;cellular process;response to heat;cellular response to growth factor stimulus;cellular response to organic substance;single-organism cellular process;cell communication;response to abiotic stimulus; 5;3;4;4;4;4;5;6;7;2;3;4;5;5;3;4;3;3;5;4;2;3;2;2;5;5;3;3;1;4;8;6;5;2;4;4;4;2;4;3;4;4;2;2;4;6;5;3;4;3; GO:0031975;GO:0044853;GO:0031982;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0098589;GO:0031965;GO:0031967;GO:0043230;GO:0043231;GO:0044428;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0044422;GO:0098590;GO:0043229;GO:0043227;GO:0044433;GO:0005737;GO:0097708;GO:0012506;GO:0044446;GO:0044444;GO:0012505;GO:0005901;GO:0031224;GO:0031090;GO:0031410;GO:0005634;GO:0005635;GO:0044459;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0098805;GO:0043226;GO:0005886;GO:1903561;GO:0045121;GO:0005575;GO:0005576; envelope;plasma membrane raft;vesicle;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;membrane region;nuclear membrane;organelle envelope;extracellular organelle;intracellular membrane-bounded organelle;nuclear part;intracellular part;membrane part;membrane microdomain;extracellular region part;organelle part;plasma membrane region;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;cytoplasm;intracellular vesicle;vesicle membrane;intracellular organelle part;cytoplasmic part;endomembrane system;caveola;intrinsic component of membrane;organelle membrane;cytoplasmic vesicle;nucleus;nuclear envelope;plasma membrane part;cytoplasmic vesicle membrane;cell part;cell;intracellular;cell periphery;extracellular exosome;whole membrane;organelle;plasma membrane;extracellular vesicle;membrane raft;cellular_component;extracellular region; 3;4;4;5;4;2;5;3;4;4;3;4;4;3;2;4;2;2;4;3;3;4;4;4;4;3;4;3;5;3;3;5;5;4;3;5;2;2;3;3;4;3;2;3;3;5;1;2; GO:0003674;GO:0005488;GO:0005543;GO:0043168;GO:0043167;GO:0008289; molecular_function;binding;phospholipid binding;anion binding;ion binding;lipid binding; 1;2;4;4;3;3; K22125 IPR006614;IPR032362;IPR012968;IPR012560;IPR012561;IPR000008;IPR029999; Peroxin/Ferlin domain;Ferlin, C-terminal domain;FerIin domain;Ferlin A-domain;Ferlin B-domain;C2 domain;Myoferlin; peroxisome Hs7305053 4268.0 M [M] Cell wall/membrane/envelope biogenesis; P17612 cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2 - [KAPCA_HUMAN] 0.42 0.363 2.994 0.85 0.324 0.37 1.157024793 nan 2.62345679 nan 8.247933884 nan 1.141975309 nan GO:0033157;GO:0051169;GO:0051168;GO:0007599;GO:0051046;GO:0051049;GO:0007596;GO:0050848;GO:0001503;GO:0044281;GO:0034199;GO:0044283;GO:0098771;GO:0032388;GO:0016042;GO:0051716;GO:0000003;GO:0003091;GO:0018210;GO:0065007;GO:0032386;GO:0046503;GO:0098662;GO:0048468;GO:0045859;GO:0007281;GO:0007283;GO:0032845;GO:0051222;GO:0007286;GO:0046486;GO:0065009;GO:0046483;GO:0042325;GO:0042327;GO:0034284;GO:0019538;GO:0010882;GO:0010881;GO:0010880;GO:0009894;GO:0009893;GO:0032412;GO:0050778;GO:0043393;GO:0071867;GO:0071868;GO:0071869;GO:0035556;GO:0051223;GO:0050789;GO:0030073;GO:0051347;GO:0051345;GO:0006886;GO:0002684;GO:0006112;GO:1901360;GO:0097553;GO:0070201;GO:0033762;GO:0006629;GO:1903649;GO:0009306;GO:0019319;GO:0007050;GO:0043412;GO:1903522;GO:0044723;GO:0016070;GO:0016071;GO:0070296;GO:2001257;GO:0071871;GO:0007498;GO:0051238;GO:0051128;GO:1903827;GO:0042176;GO:0038127;GO:0009653;GO:0031349;GO:0002220;GO:0002223;GO:0008284;GO:0035239;GO:0050878;GO:0008283;GO:0006875;GO:0006874;GO:0006873;GO:0046883;GO:0045216;GO:0044257;GO:0044255;GO:0034329;GO:0072511;GO:0035148;GO:0018107;GO:0018105;GO:0060341;GO:0042592;GO:0042593;GO:0022402;GO:0007270;GO:0006091;GO:0086065;GO:0007275;GO:0006094;GO:0002682;GO:0046824;GO:0048240;GO:0046825;GO:0007276;GO:0048598;GO:0006468;GO:0021915;GO:0000278;GO:0045087;GO:0090316;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0090257;GO:0030104;GO:1901700;GO:1901701;GO:0003006;GO:0051279;GO:0048856;GO:0006833;GO:0009914;GO:0006796;GO:2000021;GO:2000026;GO:0006793;GO:0048523;GO:0048522;GO:0008104;GO:1903779;GO:0000086;GO:2000241;GO:0032147;GO:0003012;GO:0003013;GO:0003014;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0031347;GO:0044712;GO:0044710;GO:0044711;GO:0045786;GO:0045787;GO:0070848;GO:0071331;GO:0044093;GO:0071333;GO:0033036;GO:0010522;GO:0010518;GO:0006936;GO:0006937;GO:1902656;GO:0010033;GO:0086064;GO:0051704;GO:0044248;GO:1900274;GO:0060402;GO:0009792;GO:0006807;GO:0045089;GO:0035249;GO:0045088;GO:0044267;GO:0044265;GO:0002764;GO:0044260;GO:0002768;GO:0044344;GO:0044699;GO:0032880;GO:0070509;GO:0050793;GO:0050790;GO:0019318;GO:0009888;GO:0050794;GO:0071872;GO:0051239;GO:0071870;GO:0051235;GO:0051234;GO:0051336;GO:0009953;GO:0015980;GO:0007224;GO:0022898;GO:0050896;GO:0010498;GO:0050891;GO:0051338;GO:0046827;GO:0051961;GO:0051960;GO:0046822;GO:0051966;GO:1903317;GO:0060193;GO:0060191;GO:0051246;GO:0006639;GO:0006638;GO:0019953;GO:0007043;GO:1903530;GO:0070887;GO:0007049;GO:0021532;GO:0071374;GO:0071375;GO:0044057;GO:0071377;GO:0010562;GO:0051241;GO:0010564;GO:0051247;GO:0051179;GO:0002027;GO:0032409;GO:0031399;GO:0001838;GO:0042044;GO:0048609;GO:1903829;GO:0048232;GO:0070838;GO:0070830;GO:0048731;GO:0016331;GO:0046364;GO:0034330;GO:0010863;GO:0001649;GO:0071158;GO:1901621;GO:1901620;GO:0030072;GO:0071156;GO:0060401;GO:0045937;GO:0061136;GO:0010817;GO:0022414;GO:0007268;GO:0007267;GO:0042221;GO:0035295;GO:0009746;GO:0044238;GO:0005975;GO:0009743;GO:0002790;GO:0002791;GO:0051924;GO:0044237;GO:0009749;GO:0043297;GO:0006396;GO:0006397;GO:0090087;GO:0019220;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0048469;GO:0032844;GO:0071840;GO:0009968;GO:0009966;GO:0048869;GO:0051208;GO:0051209;GO:0046879;GO:2000242;GO:0010959;GO:0048515;GO:0014020;GO:0048518;GO:0048519;GO:0042127;GO:0038179;GO:1901888;GO:0045184;GO:0007173;GO:0003002;GO:0043434;GO:0055117;GO:0055114;GO:0003008;GO:0044700;GO:0044703;GO:0044702;GO:0044707;GO:0071322;GO:0010243;GO:0071326;GO:0016051;GO:0002376;GO:0098916;GO:0048646;GO:0005996;GO:0003015;GO:0022607;GO:0071107;GO:0033674;GO:1904062;GO:0055065;GO:2000810;GO:0043170;GO:0090068;GO:0043549;GO:0006810;GO:0006812;GO:0006811;GO:0045879;GO:0006816;GO:0006952;GO:0006950;GO:0050817;GO:0045333;GO:0001678;GO:0006955;GO:0048011;GO:0030278;GO:0050796;GO:0051603;GO:0046903;GO:0070613;GO:0051604;GO:0080134;GO:0031401;GO:0002758;GO:0099536;GO:0099537;GO:0007369;GO:0030154;GO:0015833;GO:0060047;GO:1904951;GO:0008543;GO:0046777;GO:0006139;GO:1902531;GO:0051321;GO:0031329;GO:0001704;GO:0045667;GO:0032270;GO:0006508;GO:0043009;GO:0071495;GO:0032501;GO:0032504;GO:0006641;GO:1903513;GO:1903050;GO:0009987;GO:0006725;GO:0032870;GO:0002757;GO:0016485;GO:0032879;GO:0016482;GO:0090304;GO:0050776;GO:0071363;GO:0046907;GO:0071407;GO:0060606;GO:0072175;GO:0006006;GO:0044839;GO:0043269;GO:0007389;GO:0043467;GO:0051050;GO:0071705;GO:0071704;GO:0071310;GO:0048729;GO:0071702;GO:0061337;GO:0034613;GO:0006913;GO:0023061;GO:0051174;GO:0034220;GO:0009058;GO:0051649;GO:0009056;GO:0009057;GO:1902578;GO:0051641;GO:0051726;GO:0051480;GO:0021700;GO:1901652;GO:1901653;GO:1902582;GO:0071417;GO:0008589;GO:0080090;GO:0051282;GO:0051283;GO:0055074;GO:0034765;GO:0034762;GO:0010604;GO:0070727;GO:0009611;GO:0018193;GO:0035584;GO:0019725;GO:0019722;GO:0060255;GO:0060314;GO:0045992;GO:0090276;GO:0002429;GO:0030162;GO:0030163;GO:0045995;GO:0018209;GO:0090279;GO:0048871;GO:0007202;GO:0070588;GO:0007204;GO:0048878;GO:0019433;GO:0001843;GO:0006611;GO:1903651;GO:0032940;GO:0019932;GO:1901576;GO:1901575;GO:0050708;GO:1903362;GO:0060048;GO:0016043;GO:0098655;GO:0060831;GO:0014070;GO:0001841;GO:0065008;GO:0009719;GO:0008015;GO:0008016;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0001707;GO:0051445;GO:0051447;GO:1901698;GO:1901699;GO:0098660;GO:0002218;GO:0071774;GO:0035637;GO:0016310;GO:0050801;GO:0022412;GO:0050804;GO:0006941;GO:0023057;GO:0034641;GO:0006942;GO:0023052;GO:0010648;GO:0023051;GO:0010644;GO:0044242;GO:0010646;GO:0043085;GO:0072507;GO:0042886;GO:0072503;GO:0046464;GO:0046461;GO:0006996;GO:0060429;GO:0045595;GO:0030001;GO:0030003;GO:0060562;GO:0055080;GO:0055082;GO:0055085;GO:0051093;GO:0032268;GO:0009725;GO:0051098;GO:0045860;GO:0009790;GO:0032502;GO:0021904;GO:0031325;GO:1903514;GO:0031323;GO:1903047;GO:1903169;GO:0044770;GO:0044772;GO:0002009;GO:0048332;GO:0014808;GO:0033500;GO:0010467;GO:0044085;GO:0010469;GO:0010468;GO:0007154;GO:1901019;GO:0043457;GO:0007399;GO:0044087;GO:0002253;GO:0015031;GO:0001932;GO:0001934;GO:0010517; regulation of intracellular protein transport;nuclear transport;nuclear export;hemostasis;regulation of secretion;regulation of transport;blood coagulation;regulation of calcium-mediated signaling;ossification;small molecule metabolic process;activation of protein kinase A activity;small molecule biosynthetic process;inorganic ion homeostasis;positive regulation of intracellular transport;lipid catabolic process;cellular response to stimulus;reproduction;renal water homeostasis;peptidyl-threonine modification;biological regulation;regulation of intracellular transport;glycerolipid catabolic process;inorganic cation transmembrane transport;cell development;regulation of protein kinase activity;germ cell development;spermatogenesis;negative regulation of homeostatic process;positive regulation of protein transport;spermatid development;glycerolipid metabolic process;regulation of molecular function;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to monosaccharide;protein metabolic process;regulation of cardiac muscle contraction by calcium ion signaling;regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;regulation of catabolic process;positive regulation of metabolic process;regulation of ion transmembrane transporter activity;positive regulation of immune response;regulation of protein binding;response to monoamine;cellular response to monoamine stimulus;response to catecholamine;intracellular signal transduction;regulation of protein transport;regulation of biological process;insulin secretion;positive regulation of transferase activity;positive regulation of hydrolase activity;intracellular protein transport;positive regulation of immune system process;energy reserve metabolic process;organic cyclic compound metabolic process;calcium ion transmembrane import into cytosol;regulation of establishment of protein localization;response to glucagon;lipid metabolic process;regulation of cytoplasmic transport;protein secretion;hexose biosynthetic process;cell cycle arrest;macromolecule modification;regulation of blood circulation;single-organism carbohydrate metabolic process;RNA metabolic process;mRNA metabolic process;sarcoplasmic reticulum calcium ion transport;regulation of cation channel activity;response to epinephrine;mesoderm development;sequestering of metal ion;regulation of cellular component organization;regulation of cellular protein localization;regulation of protein catabolic process;ERBB signaling pathway;anatomical structure morphogenesis;positive regulation of defense response;innate immune response activating cell surface receptor signaling pathway;stimulatory C-type lectin receptor signaling pathway;positive regulation of cell proliferation;tube morphogenesis;regulation of body fluid levels;cell proliferation;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular ion homeostasis;regulation of hormone secretion;cell-cell junction organization;cellular protein catabolic process;cellular lipid metabolic process;cell junction assembly;divalent inorganic cation transport;tube formation;peptidyl-threonine phosphorylation;peptidyl-serine phosphorylation;regulation of cellular localization;homeostatic process;glucose homeostasis;cell cycle process;neuron-neuron synaptic transmission;generation of precursor metabolites and energy;cell communication involved in cardiac conduction;multicellular organism development;gluconeogenesis;regulation of immune system process;positive regulation of nucleocytoplasmic transport;sperm capacitation;regulation of protein export from nucleus;gamete generation;embryonic morphogenesis;protein phosphorylation;neural tube development;mitotic cell cycle;innate immune response;positive regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;regulation of muscle system process;water homeostasis;response to oxygen-containing compound;cellular response to oxygen-containing compound;developmental process involved in reproduction;regulation of release of sequestered calcium ion into cytosol;anatomical structure development;water transport;hormone transport;phosphate-containing compound metabolic process;regulation of ion homeostasis;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;protein localization;regulation of cardiac conduction;G2/M transition of mitotic cell cycle;regulation of reproductive process;activation of protein kinase activity;muscle system process;circulatory system process;renal system process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;regulation of defense response;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;negative regulation of cell cycle;positive regulation of cell cycle;response to growth factor;cellular response to hexose stimulus;positive regulation of molecular function;cellular response to glucose stimulus;macromolecule localization;regulation of calcium ion transport into cytosol;positive regulation of phospholipase activity;muscle contraction;regulation of muscle contraction;calcium ion import into cytosol;response to organic substance;cell communication by electrical coupling involved in cardiac conduction;multi-organism process;cellular catabolic process;regulation of phospholipase C activity;calcium ion transport into cytosol;embryo development ending in birth or egg hatching;nitrogen compound metabolic process;positive regulation of innate immune response;synaptic transmission, glutamatergic;regulation of innate immune response;cellular protein metabolic process;cellular macromolecule catabolic process;immune response-regulating signaling pathway;cellular macromolecule metabolic process;immune response-regulating cell surface receptor signaling pathway;cellular response to fibroblast growth factor stimulus;single-organism process;regulation of protein localization;calcium ion import;regulation of developmental process;regulation of catalytic activity;hexose metabolic process;tissue development;regulation of cellular process;cellular response to epinephrine stimulus;regulation of multicellular organismal process;cellular response to catecholamine stimulus;maintenance of location;establishment of localization;regulation of hydrolase activity;dorsal/ventral pattern formation;energy derivation by oxidation of organic compounds;smoothened signaling pathway;regulation of transmembrane transporter activity;response to stimulus;proteasomal protein catabolic process;multicellular organismal water homeostasis;regulation of transferase activity;positive regulation of protein export from nucleus;negative regulation of nervous system development;regulation of nervous system development;regulation of nucleocytoplasmic transport;regulation of synaptic transmission, glutamatergic;regulation of protein maturation;positive regulation of lipase activity;regulation of lipase activity;regulation of protein metabolic process;acylglycerol metabolic process;neutral lipid metabolic process;sexual reproduction;cell-cell junction assembly;regulation of secretion by cell;cellular response to chemical stimulus;cell cycle;neural tube patterning;cellular response to parathyroid hormone stimulus;cellular response to peptide hormone stimulus;regulation of system process;cellular response to glucagon stimulus;positive regulation of phosphorus metabolic process;negative regulation of multicellular organismal process;regulation of cell cycle process;positive regulation of protein metabolic process;localization;regulation of heart rate;regulation of transporter activity;regulation of protein modification process;embryonic epithelial tube formation;fluid transport;multicellular organismal reproductive process;positive regulation of cellular protein localization;male gamete generation;divalent metal ion transport;bicellular tight junction assembly;system development;morphogenesis of embryonic epithelium;monosaccharide biosynthetic process;cell junction organization;positive regulation of phospholipase C activity;osteoblast differentiation;positive regulation of cell cycle arrest;negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;peptide hormone secretion;regulation of cell cycle arrest;cytosolic calcium ion transport;positive regulation of phosphate metabolic process;regulation of proteasomal protein catabolic process;regulation of hormone levels;reproductive process;synaptic transmission;cell-cell signaling;response to chemical;tube development;response to hexose;primary metabolic process;carbohydrate metabolic process;response to carbohydrate;peptide secretion;regulation of peptide secretion;regulation of calcium ion transport;cellular metabolic process;response to glucose;apical junction assembly;RNA processing;mRNA processing;regulation of peptide transport;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;cell maturation;regulation of homeostatic process;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;sequestering of calcium ion;release of sequestered calcium ion into cytosol;hormone secretion;negative regulation of reproductive process;regulation of metal ion transport;spermatid differentiation;primary neural tube formation;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;neurotrophin signaling pathway;regulation of cell junction assembly;establishment of protein localization;epidermal growth factor receptor signaling pathway;regionalization;response to peptide hormone;regulation of cardiac muscle contraction;oxidation-reduction process;system process;single organism signaling;multi-organism reproductive process;single organism reproductive process;single-multicellular organism process;cellular response to carbohydrate stimulus;response to organonitrogen compound;cellular response to monosaccharide stimulus;carbohydrate biosynthetic process;immune system process;anterograde trans-synaptic signaling;anatomical structure formation involved in morphogenesis;monosaccharide metabolic process;heart process;cellular component assembly;response to parathyroid hormone;positive regulation of kinase activity;regulation of cation transmembrane transport;metal ion homeostasis;regulation of bicellular tight junction assembly;macromolecule metabolic process;positive regulation of cell cycle process;regulation of kinase activity;transport;cation transport;ion transport;negative regulation of smoothened signaling pathway;calcium ion transport;defense response;response to stress;coagulation;cellular respiration;cellular glucose homeostasis;immune response;neurotrophin TRK receptor signaling pathway;regulation of ossification;regulation of insulin secretion;proteolysis involved in cellular protein catabolic process;secretion;regulation of protein processing;protein maturation;regulation of response to stress;positive regulation of protein modification process;innate immune response-activating signal transduction;synaptic signaling;trans-synaptic signaling;gastrulation;cell differentiation;peptide transport;heart contraction;positive regulation of establishment of protein localization;fibroblast growth factor receptor signaling pathway;protein autophosphorylation;nucleobase-containing compound metabolic process;regulation of intracellular signal transduction;meiotic cell cycle;regulation of cellular catabolic process;formation of primary germ layer;regulation of osteoblast differentiation;positive regulation of cellular protein metabolic process;proteolysis;chordate embryonic development;cellular response to endogenous stimulus;multicellular organismal process;multicellular organism reproduction;triglyceride metabolic process;endoplasmic reticulum to cytosol transport;regulation of proteolysis involved in cellular protein catabolic process;cellular process;cellular aromatic compound metabolic process;cellular response to hormone stimulus;immune response-activating signal transduction;protein processing;regulation of localization;cytosolic transport;nucleic acid metabolic process;regulation of immune response;cellular response to growth factor stimulus;intracellular transport;cellular response to organic cyclic compound;tube closure;epithelial tube formation;glucose metabolic process;cell cycle G2/M phase transition;regulation of ion transport;pattern specification process;regulation of generation of precursor metabolites and energy;positive regulation of transport;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;tissue morphogenesis;organic substance transport;cardiac conduction;cellular protein localization;nucleocytoplasmic transport;signal release;regulation of phosphorus metabolic process;ion transmembrane transport;biosynthetic process;establishment of localization in cell;catabolic process;macromolecule catabolic process;single-organism localization;cellular localization;regulation of cell cycle;regulation of cytosolic calcium ion concentration;developmental maturation;response to peptide;cellular response to peptide;single-organism intracellular transport;cellular response to organonitrogen compound;regulation of smoothened signaling pathway;regulation of primary metabolic process;regulation of sequestering of calcium ion;negative regulation of sequestering of calcium ion;calcium ion homeostasis;regulation of ion transmembrane transport;regulation of transmembrane transport;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to wounding;peptidyl-amino acid modification;calcium-mediated signaling using intracellular calcium source;cellular homeostasis;calcium-mediated signaling;regulation of macromolecule metabolic process;regulation of ryanodine-sensitive calcium-release channel activity;negative regulation of embryonic development;regulation of peptide hormone secretion;immune response-activating cell surface receptor signaling pathway;regulation of proteolysis;protein catabolic process;regulation of embryonic development;peptidyl-serine modification;regulation of calcium ion import;multicellular organismal homeostasis;activation of phospholipase C activity;calcium ion transmembrane transport;positive regulation of cytosolic calcium ion concentration;chemical homeostasis;triglyceride catabolic process;neural tube closure;protein export from nucleus;positive regulation of cytoplasmic transport;secretion by cell;second-messenger-mediated signaling;organic substance biosynthetic process;organic substance catabolic process;regulation of protein secretion;regulation of cellular protein catabolic process;cardiac muscle contraction;cellular component organization;cation transmembrane transport;smoothened signaling pathway involved in dorsal/ventral neural tube patterning;response to organic cyclic compound;neural tube formation;regulation of biological quality;response to endogenous stimulus;blood circulation;regulation of heart contraction;wound healing;protein modification process;biological_process;metabolic process;mesoderm formation;regulation of meiotic cell cycle;negative regulation of meiotic cell cycle;response to nitrogen compound;cellular response to nitrogen compound;inorganic ion transmembrane transport;activation of innate immune response;response to fibroblast growth factor;multicellular organismal signaling;phosphorylation;ion homeostasis;cellular process involved in reproduction in multicellular organism;modulation of synaptic transmission;striated muscle contraction;negative regulation of signaling;cellular nitrogen compound metabolic process;regulation of striated muscle contraction;signaling;negative regulation of cell communication;regulation of signaling;cell communication by electrical coupling;cellular lipid catabolic process;regulation of cell communication;positive regulation of catalytic activity;divalent inorganic cation homeostasis;amide transport;cellular divalent inorganic cation homeostasis;acylglycerol catabolic process;neutral lipid catabolic process;organelle organization;epithelium development;regulation of cell differentiation;metal ion transport;cellular cation homeostasis;epithelial tube morphogenesis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;negative regulation of developmental process;regulation of cellular protein metabolic process;response to hormone;regulation of binding;positive regulation of protein kinase activity;embryo development;developmental process;dorsal/ventral neural tube patterning;positive regulation of cellular metabolic process;calcium ion transport from endoplasmic reticulum to cytosol;regulation of cellular metabolic process;mitotic cell cycle process;regulation of calcium ion transmembrane transport;cell cycle phase transition;mitotic cell cycle phase transition;morphogenesis of an epithelium;mesoderm morphogenesis;release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;carbohydrate homeostasis;gene expression;cellular component biogenesis;regulation of receptor activity;regulation of gene expression;cell communication;regulation of calcium ion transmembrane transporter activity;regulation of cellular respiration;nervous system development;regulation of cellular component biogenesis;activation of immune response;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;regulation of phospholipase activity; 6;6;8;5;5;4;5;6;4;4;10;5;7;4;5;3;2;5;8;2;5;6;7;4;7;4;6;3;4;5;5;3;4;7;7;6;4;8;7;6;4;3;6;4;5;5;6;5;5;5;2;6;6;6;6;3;5;4;8;5;6;4;6;5;7;5;5;5;4;5;6;6;7;6;5;4;4;5;5;8;3;4;6;7;4;4;4;3;8;9;6;4;5;6;4;5;7;4;8;8;4;4;7;4;9;4;5;4;8;3;6;4;7;4;4;7;4;5;4;4;6;3;4;3;5;6;4;5;3;5;3;6;5;5;4;4;4;3;3;4;4;6;3;9;4;4;4;4;5;6;7;5;4;3;4;4;4;5;8;4;7;3;5;8;5;6;7;4;6;2;4;8;6;6;3;5;10;5;5;5;5;4;6;5;2;4;10;3;4;6;4;3;7;3;6;3;3;5;6;4;6;5;2;6;5;5;5;4;5;7;5;6;7;6;5;6;5;3;6;5;4;4;5;6;6;4;7;5;3;5;5;2;4;4;6;6;5;3;3;5;8;7;4;5;6;4;9;5;6;5;6;7;6;10;6;7;4;2;8;4;3;4;7;3;4;5;6;6;7;3;8;7;6;7;5;6;3;3;3;3;5;3;2;4;4;4;5;5;6;3;6;4;6;2;2;4;6;4;4;9;5;5;7;4;3;3;3;3;3;6;4;7;5;2;7;3;5;5;4;5;7;6;8;5;4;5;6;4;6;5;5;9;4;3;4;5;6;3;7;4;6;6;5;7;5;4;6;5;5;6;5;5;6;6;3;6;8;4;5;3;5;4;5;5;5;7;4;2;3;7;6;7;2;4;5;4;6;3;6;5;4;6;5;6;5;5;7;6;5;4;5;3;5;3;5;4;5;5;5;7;5;5;5;3;4;3;5;3;3;4;10;4;5;6;5;5;5;4;4;4;9;5;4;4;4;4;7;8;4;7;4;5;4;5;5;6;5;5;8;6;4;10;8;11;5;8;6;6;5;4;6;4;4;6;6;7;3;6;7;5;5;3;3;5;6;5;5;1;2;5;4;4;4;5;6;4;4;4;6;6;4;4;6;3;4;7;2;4;3;5;5;4;5;8;5;8;7;6;4;5;4;7;7;5;7;5;4;3;5;4;4;8;5;2;6;4;7;4;5;7;5;6;5;5;6;6;5;3;4;5;4;7;6;5;3;3;5;7;7;7; GO:0044853;GO:0031514;GO:0005952;GO:0044428;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0016607;GO:0016604;GO:0005654;GO:1990351;GO:0031224;GO:0044463;GO:0044464;GO:0071944;GO:0070062;GO:0097546;GO:0070013;GO:0031594;GO:0016021;GO:0016020;GO:1902495;GO:1902494;GO:0098589;GO:1902554;GO:0042995;GO:0043234;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0034704;GO:0034702;GO:0034703;GO:0005929;GO:0044430;GO:1902911;GO:0043228;GO:0005813;GO:0005815;GO:0031974;GO:0031588;GO:0098857;GO:0098590;GO:0043229;GO:0043227;GO:0043226;GO:0005856;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0044441;GO:0005737;GO:0036126;GO:0005739;GO:0043005;GO:0045202;GO:0045121;GO:0031981;GO:0005794;GO:0048471;GO:0005634;GO:1990234;GO:0097225;GO:0097223;GO:0044451;GO:0044459;GO:0061695;GO:0005623;GO:0005622;GO:0098796;GO:0098805;GO:0097458;GO:0015630;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005576; plasma membrane raft;motile cilium;cAMP-dependent protein kinase complex;nuclear part;intracellular part;membrane part;extracellular region part;organelle part;nuclear speck;nuclear body;nucleoplasm;transporter complex;intrinsic component of membrane;cell projection part;cell part;cell periphery;extracellular exosome;ciliary base;intracellular organelle lumen;neuromuscular junction;integral component of membrane;membrane;transmembrane transporter complex;catalytic complex;membrane region;serine/threonine protein kinase complex;cell projection;protein complex;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;calcium channel complex;ion channel complex;cation channel complex;cilium;cytoskeletal part;protein kinase complex;non-membrane-bounded organelle;centrosome;microtubule organizing center;membrane-enclosed lumen;nucleotide-activated protein kinase complex;membrane microdomain;plasma membrane region;intracellular organelle;membrane-bounded organelle;organelle;cytoskeleton;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;ciliary part;cytoplasm;sperm flagellum;mitochondrion;neuron projection;synapse;membrane raft;nuclear lumen;Golgi apparatus;perinuclear region of cytoplasm;nucleus;transferase complex;sperm midpiece;sperm part;nucleoplasm part;plasma membrane part;transferase complex, transferring phosphorus-containing groups;cell;intracellular;membrane protein complex;whole membrane;neuron part;microtubule cytoskeleton;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 4;4;4;4;3;2;2;2;7;6;5;4;3;3;2;3;4;4;4;3;4;2;4;4;3;8;3;3;3;4;4;3;5;7;5;6;3;4;7;3;5;5;2;4;4;4;3;3;2;5;3;4;3;4;3;4;4;5;4;2;5;5;4;5;5;5;4;3;5;3;6;2;3;3;3;3;6;3;3;2;1;2; GO:0000166;GO:0004712;GO:0005488;GO:1901265;GO:0017076;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0004691;GO:0004690;GO:0051018;GO:0001883;GO:0001882;GO:0016740;GO:0036094;GO:0019899;GO:0031625;GO:0005515;GO:0034237;GO:0004674;GO:0004672;GO:0019901;GO:1901363;GO:0019900;GO:0003674;GO:0005524;GO:0016301;GO:0003824;GO:0097159;GO:0043167;GO:0030554;GO:0044389;GO:0097367;GO:0032549;GO:0035639;GO:0043168; nucleotide binding;protein serine/threonine/tyrosine kinase activity;binding;nucleoside phosphate binding;purine nucleotide binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;cAMP-dependent protein kinase activity;cyclic nucleotide-dependent protein kinase activity;protein kinase A binding;purine nucleoside binding;nucleoside binding;transferase activity;small molecule binding;enzyme binding;ubiquitin protein ligase binding;protein binding;protein kinase A regulatory subunit binding;protein serine/threonine kinase activity;protein kinase activity;protein kinase binding;heterocyclic compound binding;kinase binding;molecular_function;ATP binding;kinase activity;catalytic activity;organic cyclic compound binding;ion binding;adenyl nucleotide binding;ubiquitin-like protein ligase binding;carbohydrate derivative binding;ribonucleoside binding;purine ribonucleoside triphosphate binding;anion binding; 4;7;2;4;5;5;4;6;5;6;4;9;8;4;5;4;3;3;4;6;3;5;7;6;6;3;5;1;6;5;2;3;3;6;5;3;5;5;4; K04345 map04010;map04014;map04020;map04024;map04062;map04113;map04114;map04211;map04213;map04261;map04270;map04310;map04340;map04540;map04611;map04713;map04720;map04723;map04724;map04725;map04726;map04727;map04728;map04740;map04742;map04750;map04910;map04911;map04912;map04913;map04914;map04915;map04916;map04918;map04919;map04921;map04922;map04923;map04924;map04925;map04961;map04962;map04970;map04971;map04976;map05012;map05020;map05030;map05031;map05032;map05110;map05146;map05166;map05169;map05200;map05203;map05205;map05414; MAPK signaling pathway;Ras signaling pathway;Calcium signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;Meiosis - yeast;Oocyte meiosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Adrenergic signaling in cardiomyocytes;Vascular smooth muscle contraction;Wnt signaling pathway;Hedgehog signaling pathway;Gap junction;Platelet activation;Circadian entrainment;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Cholinergic synapse;Serotonergic synapse;GABAergic synapse;Dopaminergic synapse;Olfactory transduction;Taste transduction;Inflammatory mediator regulation of TRP channels;Insulin signaling pathway;Insulin secretion;GnRH signaling pathway;Ovarian steroidogenesis;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Melanogenesis;Thyroid hormone synthesis;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Glucagon signaling pathway;Regulation of lipolysis in adipocytes;Renin secretion;Aldosterone synthesis and secretion;Endocrine and other factor-regulated calcium reabsorption;Vasopressin-regulated water reabsorption;Salivary secretion;Gastric acid secretion;Bile secretion;Parkinson's disease;Prion diseases;Cocaine addiction;Amphetamine addiction;Morphine addiction;Vibrio cholerae infection;Amoebiasis;HTLV-I infection;Epstein-Barr virus infection;Pathways in cancer;Viral carcinogenesis;Proteoglycans in cancer;Dilated cardiomyopathy; IPR000961;IPR017441;IPR008271;IPR011009;IPR000719; AGC-kinase, C-terminal;Protein kinase, ATP binding site;Serine/threonine-protein kinase, active site;Protein kinase-like domain;Protein kinase domain; mitochondria Hs4506055 729.0 T [T] Signal transduction mechanisms; Q8IXE1 Olfactory receptor 4N5 OS=Homo sapiens OX=9606 GN=OR4N5 PE=3 SV=1 - [OR4N5_HUMAN] 1.504 0.475 1.388 1.215 0.529 0.935 3.166315789 nan 2.296786389 nan 2.922105263 nan 1.767485822 nan GO:0051716;GO:0007165;GO:0007154;GO:0009593;GO:0050789;GO:0065007;GO:0044699;GO:0007186;GO:0032501;GO:0050877;GO:0007606;GO:0007600;GO:0050794;GO:0008150;GO:0023052;GO:0042221;GO:0003008;GO:0044700;GO:0051606;GO:0050896;GO:0044763;GO:0009987;GO:0050906;GO:0050907; cellular response to stimulus;signal transduction;cell communication;detection of chemical stimulus;regulation of biological process;biological regulation;single-organism process;G-protein coupled receptor signaling pathway;multicellular organismal process;neurological system process;sensory perception of chemical stimulus;sensory perception;regulation of cellular process;biological_process;signaling;response to chemical;system process;single organism signaling;detection of stimulus;response to stimulus;single-organism cellular process;cellular process;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception; 3;4;4;4;2;2;2;5;2;4;6;5;3;1;2;3;3;3;3;2;3;2;4;5; GO:0071944;GO:0031224;GO:0016021;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044425; cell periphery;intrinsic component of membrane;integral component of membrane;membrane;plasma membrane;cell part;cell;cellular_component;membrane part; 3;3;4;2;3;2;2;1;2; GO:0038023;GO:0060089;GO:0003674;GO:0004872;GO:0004871;GO:0004930;GO:0004888;GO:0004984;GO:0099600; signaling receptor activity;molecular transducer activity;molecular_function;receptor activity;signal transducer activity;G-protein coupled receptor activity;transmembrane signaling receptor activity;olfactory receptor activity;transmembrane receptor activity; 3;2;1;3;2;5;4;5;4; K04257 map04740; Olfactory transduction; IPR017452;IPR000276;IPR000725; GPCR, rhodopsin-like, 7TM;G protein-coupled receptor, rhodopsin-like;Olfactory receptor; plasma membrane Q9ULH1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4 - [ASAP1_HUMAN] 1.041 0.801 1.286 0.993 1.06 0.724 1.299625468 0.209075319 0.936792453 0.401223755 1.605493134 0.0834489 0.683018868 0.061149336 GO:0048468;GO:0016358;GO:0031345;GO:0031344;GO:0071840;GO:0048869;GO:0045665;GO:0045664;GO:0060998;GO:0010721;GO:0048519;GO:0060996;GO:0010977;GO:0010975;GO:0044707;GO:0061000;GO:0031175;GO:0050789;GO:0000902;GO:0016043;GO:0065007;GO:0060271;GO:0050767;GO:0050793;GO:0050794;GO:0008150;GO:0051239;GO:0051960;GO:0030154;GO:0051129;GO:0051128;GO:0060284;GO:0009653;GO:0044699;GO:0051241;GO:0050768;GO:2000171;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0048858;GO:0051093;GO:0007399;GO:0050773;GO:0048731;GO:0030030;GO:0007275;GO:0051961;GO:0032989;GO:0048666;GO:0030182;GO:0044767;GO:0044763;GO:0022008;GO:0006996;GO:0048699;GO:0032990;GO:0048856;GO:2000026;GO:0048523; cell development;dendrite development;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;cellular developmental process;negative regulation of neuron differentiation;regulation of neuron differentiation;regulation of dendritic spine development;negative regulation of cell development;negative regulation of biological process;dendritic spine development;negative regulation of neuron projection development;regulation of neuron projection development;single-multicellular organism process;negative regulation of dendritic spine development;neuron projection development;regulation of biological process;cell morphogenesis;cellular component organization;biological regulation;cilium morphogenesis;regulation of neurogenesis;regulation of developmental process;regulation of cellular process;biological_process;regulation of multicellular organismal process;regulation of nervous system development;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cell development;anatomical structure morphogenesis;single-organism process;negative regulation of multicellular organismal process;negative regulation of neurogenesis;negative regulation of dendrite development;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;cell projection morphogenesis;negative regulation of developmental process;nervous system development;regulation of dendrite development;system development;cell projection organization;multicellular organism development;negative regulation of nervous system development;cellular component morphogenesis;neuron development;neuron differentiation;single-organism developmental process;single-organism cellular process;neurogenesis;organelle organization;generation of neurons;cell part morphogenesis;anatomical structure development;regulation of multicellular organismal development;negative regulation of cellular process; 4;4;5;5;2;4;6;7;5;5;2;4;6;6;3;5;5;2;5;3;2;6;6;3;3;1;3;5;5;4;4;5;3;2;3;5;5;2;2;2;4;4;5;3;5;5;4;4;4;4;4;5;6;3;3;6;4;7;5;3;4;3; GO:0030425;GO:0016020;GO:0036477;GO:0042995;GO:0005829;GO:0044424;GO:0044444;GO:0005737;GO:0044456;GO:0043005;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0045202;GO:0044309;GO:0097458;GO:0043197;GO:0005575;GO:0098794; dendrite;membrane;somatodendritic compartment;cell projection;cytosol;intracellular part;cytoplasmic part;cytoplasm;synapse part;neuron projection;cell projection part;cell part;cell;intracellular;synapse;neuron spine;neuron part;dendritic spine;cellular_component;postsynapse; 5;2;4;3;5;3;4;4;2;4;3;2;2;3;2;5;3;4;1;3; GO:0098772;GO:0005546;GO:0005547;GO:0046872;GO:0005096;GO:0030695;GO:0003674;GO:0005488;GO:1902936;GO:0043168;GO:1901981;GO:0035091;GO:0005543;GO:0043169;GO:0043167;GO:0008289;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;phosphatidylinositol-4,5-bisphosphate binding;phosphatidylinositol-3,4,5-trisphosphate binding;metal ion binding;GTPase activator activity;GTPase regulator activity;molecular_function;binding;phosphatidylinositol bisphosphate binding;anion binding;phosphatidylinositol phosphate binding;phosphatidylinositol binding;phospholipid binding;cation binding;ion binding;lipid binding;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;8;7;5;5;5;1;2;7;4;6;5;4;4;3;3;4;4;3; K12488 map04144;map04666; Endocytosis;Fc gamma R-mediated phagocytosis; IPR027267;IPR001164;IPR020683;IPR001452;IPR002110;IPR035676;IPR001849;IPR011993; Arfaptin homology (AH) domain/BAR domain;Arf GTPase activating protein;Ankyrin repeat-containing domain;SH3 domain;Ankyrin repeat;ASAP1, SH3 domain;Pleckstrin homology domain;PH domain-like; nucleus Hs22047742 1183.0 T [T] Signal transduction mechanisms; Q99439 Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4 - [CNN2_HUMAN] 0.903 0.964 1.258 0.906 1.059 1.126 0.936721992 nan 0.855524079 nan 1.304979253 nan 1.063267233 nan GO:0006909;GO:0019222;GO:0051049;GO:0071840;GO:0010604;GO:0009611;GO:0048513;GO:0048518;GO:0048519;GO:0042127;GO:0051051;GO:0060255;GO:0016192;GO:0044707;GO:0048870;GO:0002376;GO:0009893;GO:0006928;GO:0051674;GO:0050789;GO:0016043;GO:0065007;GO:0016477;GO:0006810;GO:0042060;GO:0050794;GO:0006950;GO:0008150;GO:0008152;GO:0048731;GO:0051234;GO:0002520;GO:0006897;GO:0050896;GO:2000145;GO:2000146;GO:0051129;GO:0051128;GO:0044699;GO:0050764;GO:0050765;GO:0032502;GO:0006996;GO:0032501;GO:0008283;GO:0009987;GO:0051271;GO:0060627;GO:0051270;GO:0032879;GO:0043170;GO:0010628;GO:0030097;GO:0031032;GO:0030036;GO:0007275;GO:0071704;GO:0010467;GO:0048534;GO:0010468;GO:0030336;GO:0030334;GO:0030029;GO:0044767;GO:0044765;GO:0044763;GO:0030100;GO:0051179;GO:1902578;GO:0040011;GO:0040013;GO:0040012;GO:0007010;GO:0048856;GO:1902589;GO:0045806;GO:0048523; phagocytosis;regulation of metabolic process;regulation of transport;cellular component organization or biogenesis;positive regulation of macromolecule metabolic process;response to wounding;animal organ development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;negative regulation of transport;regulation of macromolecule metabolic process;vesicle-mediated transport;single-multicellular organism process;cell motility;immune system process;positive regulation of metabolic process;movement of cell or subcellular component;localization of cell;regulation of biological process;cellular component organization;biological regulation;cell migration;transport;wound healing;regulation of cellular process;response to stress;biological_process;metabolic process;system development;establishment of localization;immune system development;endocytosis;response to stimulus;regulation of cell motility;negative regulation of cell motility;negative regulation of cellular component organization;regulation of cellular component organization;single-organism process;regulation of phagocytosis;negative regulation of phagocytosis;developmental process;organelle organization;multicellular organismal process;cell proliferation;cellular process;negative regulation of cellular component movement;regulation of vesicle-mediated transport;regulation of cellular component movement;regulation of localization;macromolecule metabolic process;positive regulation of gene expression;hemopoiesis;actomyosin structure organization;actin cytoskeleton organization;multicellular organism development;organic substance metabolic process;gene expression;hematopoietic or lymphoid organ development;regulation of gene expression;negative regulation of cell migration;regulation of cell migration;actin filament-based process;single-organism developmental process;single-organism transport;single-organism cellular process;regulation of endocytosis;localization;single-organism localization;locomotion;negative regulation of locomotion;regulation of locomotion;cytoskeleton organization;anatomical structure development;single-organism organelle organization;negative regulation of endocytosis;negative regulation of cellular process; 5;3;4;2;4;4;4;2;2;4;3;4;5;3;3;2;3;4;3;2;3;2;4;4;5;3;3;1;2;4;3;3;6;2;4;4;4;4;2;6;5;2;4;2;3;2;4;4;4;3;4;5;5;6;5;4;3;5;4;5;5;5;4;3;4;3;5;2;3;2;3;3;5;3;4;4;3; GO:0043228;GO:0044424;GO:0043232;GO:0043229;GO:0005622;GO:0005856;GO:0044464;GO:0005623;GO:0043226;GO:0005575; non-membrane-bounded organelle;intracellular part;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular;cytoskeleton;cell part;cell;organelle;cellular_component; 3;3;4;3;3;5;2;2;2;1; IPR001715;IPR001997;IPR000557;IPR003096;IPR029974; Calponin homology domain;Calponin/LIMCH1;Calponin repeat;Smooth muscle protein/calponin;Calponin-2; cytosol Hs4758018 645.0 Z [Z] Cytoskeleton; Q6PIY5 Armadillo-like helical domain containing protein 1 OS=Homo sapiens OX=9606 GN=ARMH1 PE=2 SV=2 - [ARMD1_HUMAN] 1.056 1.375 0.885 0.863 1.052 0.89 0.768 nan 0.820342205 nan 0.643636364 nan 0.846007605 nan IPR016024;IPR011989; Armadillo-type fold;Armadillo-like helical; cytosol A8MTY0 Zinc finger protein 724 OS=Homo sapiens OX=9606 GN=ZNF724 PE=2 SV=3 - [ZN724_HUMAN] 1.502 1.183 0.369 0.741 1.58 0.531 1.269653424 nan 0.468987342 nan 0.31191885 nan 0.336075949 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0001012;GO:0000977;GO:0043169;GO:0001159;GO:0003674;GO:0003677;GO:1990837;GO:0044212;GO:0043565;GO:0000987;GO:0003690;GO:0046872;GO:0003676;GO:0001067;GO:0043167;GO:0097159;GO:0000976;GO:0000975;GO:0000978;GO:1901363;GO:0005488; RNA polymerase II regulatory region DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;cation binding;core promoter proximal region DNA binding;molecular_function;DNA binding;sequence-specific double-stranded DNA binding;transcription regulatory region DNA binding;sequence-specific DNA binding;core promoter proximal region sequence-specific DNA binding;double-stranded DNA binding;metal ion binding;nucleic acid binding;regulatory region nucleic acid binding;ion binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;heterocyclic compound binding;binding; 8;9;4;8;1;5;7;7;6;9;6;5;4;5;3;3;8;6;10;3;2; IPR013087;IPR013083;IPR001909; Zinc finger C2H2-type;Zinc finger, RING/FYVE/PHD-type;Krueppel-associated box; nucleus Hs18591424 920.0 R [R] General function prediction only; P08246 Neutrophil elastase OS=Homo sapiens OX=9606 GN=ELANE PE=1 SV=1 - [ELNE_HUMAN] 1.148 0.759 1.252 1.098 0.711 1.105 1.512516469 0.097510025 1.544303797 0.409071261 1.649538867 0.171240218 1.554149086 0.268436538 GO:0006909;GO:0042033;GO:0042035;GO:0042036;GO:0098771;GO:0051716;GO:0043207;GO:0000165;GO:0045859;GO:0050832;GO:0046483;GO:0042325;GO:0042327;GO:0009607;GO:0042089;GO:0009605;GO:0019538;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0044130;GO:0051347;GO:0002684;GO:0002682;GO:1901360;GO:0051873;GO:0018130;GO:0043410;GO:0043412;GO:0002526;GO:0016070;GO:0030574;GO:0010557;GO:0010556;GO:0001878;GO:0010558;GO:0009411;GO:0009416;GO:0044126;GO:0045079;GO:0000122;GO:0045073;GO:0032677;GO:0008284;GO:0008283;GO:0006875;GO:0006874;GO:0006873;GO:0098542;GO:0044259;GO:0070947;GO:0070942;GO:0070943;GO:0045926;GO:0042592;GO:0050900;GO:0033993;GO:2000112;GO:2000113;GO:0043062;GO:0006468;GO:0019219;GO:0006464;GO:0044765;GO:0044763;GO:0050755;GO:1901700;GO:0040013;GO:0040012;GO:0006796;GO:0006793;GO:0032757;GO:0048523;GO:0048522;GO:0031348;GO:0007165;GO:0031347;GO:0044712;GO:0044710;GO:0050727;GO:0001909;GO:0044093;GO:0001906;GO:0006935;GO:2001141;GO:0051702;GO:0051707;GO:0010033;GO:0051704;GO:0010629;GO:0006807;GO:0044267;GO:0044243;GO:0044260;GO:0006366;GO:0050790;GO:0009889;GO:0050794;GO:0051239;GO:0051234;GO:0051174;GO:0006897;GO:0050896;GO:0051338;GO:0032717;GO:0010562;GO:0032102;GO:0032101;GO:0009314;GO:0043406;GO:0043405;GO:0032963;GO:0044699;GO:0043408;GO:0051248;GO:0051240;GO:0051241;GO:0051246;GO:0051247;GO:0051179;GO:0031399;GO:1903034;GO:1903035;GO:0040011;GO:0002237;GO:0045934;GO:0042228;GO:0022411;GO:0055065;GO:0042221;GO:0009628;GO:0051883;GO:0009620;GO:0044237;GO:0044236;GO:0044403;GO:0019220;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:1901362;GO:0071840;GO:0009966;GO:0009967;GO:0051817;GO:0048518;GO:0048519;GO:0051818;GO:0042127;GO:0044700;GO:0016192;GO:0044707;GO:0002376;GO:0033002;GO:0033674;GO:0006928;GO:0051674;GO:0097659;GO:0002438;GO:0043549;GO:0002437;GO:0016477;GO:0006810;GO:0050728;GO:0006952;GO:0043900;GO:0043901;GO:0006954;GO:0006955;GO:0034654;GO:1902533;GO:1902531;GO:0044271;GO:0043903;GO:0080134;GO:0031401;GO:0006950;GO:0006355;GO:0006357;GO:0006351;GO:0032774;GO:0044110;GO:0044116;GO:0044117;GO:0006139;GO:0051852;GO:0051851;GO:0032270;GO:0006508;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0050776;GO:0051253;GO:0051252;GO:0050778;GO:0001816;GO:0001817;GO:0001818;GO:0001819;GO:0032602;GO:0071704;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0009056;GO:0009057;GO:1902578;GO:0080090;GO:0050920;GO:0055074;GO:0050922;GO:0023014;GO:0010605;GO:0010604;GO:0042330;GO:0009617;GO:0009611;GO:0044419;GO:0019725;GO:0060255;GO:0030163;GO:0044146;GO:0044144;GO:0045416;GO:0045414;GO:0048870;GO:0045415;GO:0048878;GO:0030198;GO:0019438;GO:0032642;GO:0042742;GO:0032496;GO:1901576;GO:1901575;GO:0045937;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:0036211;GO:0008150;GO:0008152;GO:0031640;GO:0048659;GO:0016310;GO:0050801;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043085;GO:0072507;GO:0072503;GO:0044364;GO:0022617;GO:0044238;GO:0045892;GO:0030003;GO:0055080;GO:0055082;GO:0032268;GO:0043170;GO:0045860;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0040007;GO:0040008;GO:0010467;GO:0010468;GO:0042108;GO:0048660;GO:0048661;GO:0042107;GO:0032637;GO:0007154;GO:0002443;GO:0002444;GO:0002446;GO:0001934;GO:0032682;GO:0002252;GO:0001932;GO:0035821; phagocytosis;chemokine biosynthetic process;regulation of cytokine biosynthetic process;negative regulation of cytokine biosynthetic process;inorganic ion homeostasis;cellular response to stimulus;response to external biotic stimulus;MAPK cascade;regulation of protein kinase activity;defense response to fungus;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to biotic stimulus;cytokine biosynthetic process;response to external stimulus;protein metabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;negative regulation of growth of symbiont in host;positive regulation of transferase activity;positive regulation of immune system process;regulation of immune system process;organic cyclic compound metabolic process;killing by host of symbiont cells;heterocycle biosynthetic process;positive regulation of MAPK cascade;macromolecule modification;acute inflammatory response;RNA metabolic process;collagen catabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;response to yeast;negative regulation of macromolecule biosynthetic process;response to UV;response to light stimulus;regulation of growth of symbiont in host;negative regulation of chemokine biosynthetic process;negative regulation of transcription from RNA polymerase II promoter;regulation of chemokine biosynthetic process;regulation of interleukin-8 production;positive regulation of cell proliferation;cell proliferation;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular ion homeostasis;defense response to other organism;multicellular organismal macromolecule metabolic process;neutrophil mediated killing of fungus;neutrophil mediated cytotoxicity;neutrophil mediated killing of symbiont cell;negative regulation of growth;homeostatic process;leukocyte migration;response to lipid;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;extracellular structure organization;protein phosphorylation;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism transport;single-organism cellular process;chemokine metabolic process;response to oxygen-containing compound;negative regulation of locomotion;regulation of locomotion;phosphate-containing compound metabolic process;phosphorus metabolic process;positive regulation of interleukin-8 production;negative regulation of cellular process;positive regulation of cellular process;negative regulation of defense response;signal transduction;regulation of defense response;single-organism catabolic process;single-organism metabolic process;regulation of inflammatory response;leukocyte mediated cytotoxicity;positive regulation of molecular function;cell killing;chemotaxis;regulation of RNA biosynthetic process;interaction with symbiont;response to other organism;response to organic substance;multi-organism process;negative regulation of gene expression;nitrogen compound metabolic process;cellular protein metabolic process;multicellular organism catabolic process;cellular macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of phosphorus metabolic process;endocytosis;response to stimulus;regulation of transferase activity;negative regulation of interleukin-8 production;positive regulation of phosphorus metabolic process;negative regulation of response to external stimulus;regulation of response to external stimulus;response to radiation;positive regulation of MAP kinase activity;regulation of MAP kinase activity;collagen metabolic process;single-organism process;regulation of MAPK cascade;negative regulation of protein metabolic process;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;localization;regulation of protein modification process;regulation of response to wounding;negative regulation of response to wounding;locomotion;response to molecule of bacterial origin;negative regulation of nucleobase-containing compound metabolic process;interleukin-8 biosynthetic process;cellular component disassembly;metal ion homeostasis;response to chemical;response to abiotic stimulus;killing of cells in other organism involved in symbiotic interaction;response to fungus;cellular metabolic process;multicellular organism metabolic process;symbiosis, encompassing mutualism through parasitism;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;regulation of signal transduction;positive regulation of signal transduction;modification of morphology or physiology of other organism involved in symbiotic interaction;positive regulation of biological process;negative regulation of biological process;disruption of cells of other organism involved in symbiotic interaction;regulation of cell proliferation;single organism signaling;vesicle-mediated transport;single-multicellular organism process;immune system process;muscle cell proliferation;positive regulation of kinase activity;movement of cell or subcellular component;localization of cell;nucleic acid-templated transcription;acute inflammatory response to antigenic stimulus;regulation of kinase activity;inflammatory response to antigenic stimulus;cell migration;transport;negative regulation of inflammatory response;defense response;regulation of multi-organism process;negative regulation of multi-organism process;inflammatory response;immune response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;cellular nitrogen compound biosynthetic process;regulation of symbiosis, encompassing mutualism through parasitism;regulation of response to stress;positive regulation of protein modification process;response to stress;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;growth involved in symbiotic interaction;growth of symbiont involved in interaction with host;growth of symbiont in host;nucleobase-containing compound metabolic process;disruption by host of symbiont cells;modification by host of symbiont morphology or physiology;positive regulation of cellular protein metabolic process;proteolysis;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;regulation of immune response;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of immune response;cytokine production;regulation of cytokine production;negative regulation of cytokine production;positive regulation of cytokine production;chemokine production;organic substance metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;catabolic process;macromolecule catabolic process;single-organism localization;regulation of primary metabolic process;regulation of chemotaxis;calcium ion homeostasis;negative regulation of chemotaxis;signal transduction by protein phosphorylation;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;taxis;response to bacterium;response to wounding;interspecies interaction between organisms;cellular homeostasis;regulation of macromolecule metabolic process;protein catabolic process;negative regulation of growth of symbiont involved in interaction with host;modulation of growth of symbiont involved in interaction with host;positive regulation of interleukin-8 biosynthetic process;regulation of interleukin-8 biosynthetic process;cell motility;negative regulation of interleukin-8 biosynthetic process;chemical homeostasis;extracellular matrix organization;aromatic compound biosynthetic process;regulation of chemokine production;defense response to bacterium;response to lipopolysaccharide;organic substance biosynthetic process;organic substance catabolic process;positive regulation of phosphate metabolic process;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;protein modification process;biological_process;metabolic process;killing of cells of other organism;smooth muscle cell proliferation;phosphorylation;ion homeostasis;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;positive regulation of catalytic activity;divalent inorganic cation homeostasis;cellular divalent inorganic cation homeostasis;disruption of cells of other organism;extracellular matrix disassembly;primary metabolic process;negative regulation of transcription, DNA-templated;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of cellular protein metabolic process;macromolecule metabolic process;positive regulation of protein kinase activity;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;growth;regulation of growth;gene expression;regulation of gene expression;positive regulation of cytokine biosynthetic process;regulation of smooth muscle cell proliferation;positive regulation of smooth muscle cell proliferation;cytokine metabolic process;interleukin-8 production;cell communication;leukocyte mediated immunity;myeloid leukocyte mediated immunity;neutrophil mediated immunity;positive regulation of protein phosphorylation;negative regulation of chemokine production;immune effector process;regulation of protein phosphorylation;modification of morphology or physiology of other organism; 5;6;5;5;7;3;4;5;7;5;4;7;7;3;5;3;4;3;3;4;4;9;5;8;2;5;6;3;3;4;5;5;6;5;6;5;5;5;5;5;5;6;5;4;6;7;6;5;4;3;8;9;6;4;5;6;4;5;3;4;3;5;6;6;4;7;5;6;4;3;6;4;3;3;5;4;5;3;3;4;4;5;4;3;5;3;4;2;4;6;4;3;4;2;5;3;5;5;4;7;4;4;3;3;3;5;6;2;5;5;5;4;4;4;7;7;6;2;6;5;3;3;5;5;2;6;5;4;2;5;5;4;4;8;3;3;4;4;3;4;4;6;3;3;3;3;5;2;4;4;4;2;2;5;4;3;5;3;2;4;7;4;3;7;5;6;4;4;4;5;4;3;3;5;3;5;5;5;5;4;4;6;3;6;7;6;6;3;4;5;4;5;5;5;5;2;2;4;7;7;4;5;5;4;4;4;4;4;5;3;6;3;5;4;4;3;5;3;4;4;9;4;4;4;4;3;4;4;3;4;4;5;4;4;5;5;3;5;5;5;5;5;5;5;4;4;6;3;2;3;3;5;1;2;3;5;6;6;3;4;4;2;5;3;4;4;5;8;8;4;5;3;6;7;7;5;5;4;8;5;5;5;4;4;4;5;2;3;5;5;5;5;5;5;5;4;4;5;6;7;5;3;7;3; GO:0044424;GO:0044421;GO:0044464;GO:0005615;GO:0070062;GO:0016023;GO:0099503;GO:0043234;GO:0043230;GO:0043231;GO:0030141;GO:0017053;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0031982;GO:0044444;GO:0005737;GO:0009986;GO:0031988;GO:0097708;GO:1903561;GO:0031410;GO:0005623;GO:0005576;GO:0032991;GO:0005575; intracellular part;extracellular region part;cell part;extracellular space;extracellular exosome;cytoplasmic, membrane-bounded vesicle;secretory vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;secretory granule;transcriptional repressor complex;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;vesicle;cytoplasmic part;cytoplasm;cell surface;membrane-bounded vesicle;intracellular vesicle;extracellular vesicle;cytoplasmic vesicle;cell;extracellular region;macromolecular complex;cellular_component; 3;2;2;3;4;5;6;3;3;4;4;4;3;3;3;2;3;4;4;4;3;5;4;3;5;2;2;2;1; GO:0004252;GO:0017171;GO:0005488;GO:0016787;GO:1901681;GO:0070011;GO:0019955;GO:0019899;GO:0002020;GO:0005515;GO:0004175;GO:0003674;GO:0003824;GO:0003714;GO:0003712;GO:0008233;GO:0008236;GO:0043167;GO:0001076;GO:0097367;GO:0000989;GO:0000988;GO:0043168;GO:0005539;GO:0001104;GO:0001106;GO:0008201;GO:0001191; serine-type endopeptidase activity;serine hydrolase activity;binding;hydrolase activity;sulfur compound binding;peptidase activity, acting on L-amino acid peptides;cytokine binding;enzyme binding;protease binding;protein binding;endopeptidase activity;molecular_function;catalytic activity;transcription corepressor activity;transcription cofactor activity;peptidase activity;serine-type peptidase activity;ion binding;transcription factor activity, RNA polymerase II transcription factor binding;carbohydrate derivative binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;anion binding;glycosaminoglycan binding;RNA polymerase II transcription cofactor activity;RNA polymerase II transcription corepressor activity;heparin binding;transcriptional repressor activity, RNA polymerase II transcription factor binding; 6;4;2;3;3;5;4;4;5;3;6;1;2;5;4;4;5;3;4;3;3;2;4;4;5;6;4;5; K01327 map05202;map05322; Transcriptional misregulation in cancer;Systemic lupus erythematosus; IPR001254;IPR009003;IPR033116;IPR018114;IPR001314; Serine proteases, trypsin domain;Peptidase S1, PA clan;Serine proteases, trypsin family, serine active site;Serine proteases, trypsin family, histidine active site;Peptidase S1A, chymotrypsin family; extracellular Hs4503549 535.0 E [E] Amino acid transport and metabolism; Q9Y2I7 1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3 - [FYV1_HUMAN] 1.921 0.702 0.462 1.452 0.818 0.83 2.736467236 nan 1.775061125 nan 0.658119658 nan 1.014669927 nan GO:0000045;GO:0008104;GO:0019222;GO:1904562;GO:0048583;GO:0007165;GO:0032989;GO:0071840;GO:0044710;GO:0044711;GO:0070727;GO:0048869;GO:0033043;GO:0065007;GO:0033036;GO:0042147;GO:0046488;GO:0008366;GO:0046486;GO:0051128;GO:0016192;GO:0016197;GO:0044700;GO:0044707;GO:0031667;GO:0048646;GO:0033554;GO:0009894;GO:0022607;GO:0035556;GO:0050789;GO:1901576;GO:0009653;GO:0042552;GO:0010646;GO:0016043;GO:0044281;GO:0006810;GO:0006629;GO:0051716;GO:0050794;GO:0019637;GO:0006950;GO:0008150;GO:0008152;GO:0048731;GO:0051234;GO:0090407;GO:0046907;GO:0008654;GO:0050896;GO:0080135;GO:0044765;GO:0032107;GO:0032104;GO:0036092;GO:0032101;GO:0010927;GO:0044249;GO:0023052;GO:0044699;GO:0044248;GO:0051641;GO:0032502;GO:0006644;GO:0032501;GO:0031323;GO:0009987;GO:0006661;GO:0044255;GO:0016482;GO:2000785;GO:0007033;GO:0007034;GO:0033365;GO:0046474;GO:0080134;GO:0034504;GO:0009991;GO:0006650;GO:0031329;GO:0016236;GO:0032288;GO:0044767;GO:0007272;GO:0007275;GO:0045017;GO:0071704;GO:1902115;GO:0010506;GO:0009605;GO:0016241;GO:0006914;GO:0034613;GO:0009058;GO:0044763;GO:0051649;GO:0007154;GO:0070925;GO:0009056;GO:0051179;GO:1902578;GO:0008610;GO:0006996;GO:0044238;GO:1905037;GO:0007399;GO:0048856;GO:0044237;GO:0044087;GO:0006796;GO:0044085;GO:0006793;GO:1902582;GO:0044088; autophagosome assembly;protein localization;regulation of metabolic process;phosphatidylinositol 5-phosphate metabolic process;regulation of response to stimulus;signal transduction;cellular component morphogenesis;cellular component organization or biogenesis;single-organism metabolic process;single-organism biosynthetic process;cellular macromolecule localization;cellular developmental process;regulation of organelle organization;biological regulation;macromolecule localization;retrograde transport, endosome to Golgi;phosphatidylinositol metabolic process;axon ensheathment;glycerolipid metabolic process;regulation of cellular component organization;vesicle-mediated transport;endosomal transport;single organism signaling;single-multicellular organism process;response to nutrient levels;anatomical structure formation involved in morphogenesis;cellular response to stress;regulation of catabolic process;cellular component assembly;intracellular signal transduction;regulation of biological process;organic substance biosynthetic process;anatomical structure morphogenesis;myelination;regulation of cell communication;cellular component organization;small molecule metabolic process;transport;lipid metabolic process;cellular response to stimulus;regulation of cellular process;organophosphate metabolic process;response to stress;biological_process;metabolic process;system development;establishment of localization;organophosphate biosynthetic process;intracellular transport;phospholipid biosynthetic process;response to stimulus;regulation of cellular response to stress;single-organism transport;regulation of response to nutrient levels;regulation of response to extracellular stimulus;phosphatidylinositol-3-phosphate biosynthetic process;regulation of response to external stimulus;cellular component assembly involved in morphogenesis;cellular biosynthetic process;signaling;single-organism process;cellular catabolic process;cellular localization;developmental process;phospholipid metabolic process;multicellular organismal process;regulation of cellular metabolic process;cellular process;phosphatidylinositol biosynthetic process;cellular lipid metabolic process;cytosolic transport;regulation of autophagosome assembly;vacuole organization;vacuolar transport;protein localization to organelle;glycerophospholipid biosynthetic process;regulation of response to stress;protein localization to nucleus;response to extracellular stimulus;glycerophospholipid metabolic process;regulation of cellular catabolic process;macroautophagy;myelin assembly;single-organism developmental process;ensheathment of neurons;multicellular organism development;glycerolipid biosynthetic process;organic substance metabolic process;regulation of organelle assembly;regulation of autophagy;response to external stimulus;regulation of macroautophagy;autophagy;cellular protein localization;biosynthetic process;single-organism cellular process;establishment of localization in cell;cell communication;organelle assembly;catabolic process;localization;single-organism localization;lipid biosynthetic process;organelle organization;primary metabolic process;autophagosome organization;nervous system development;anatomical structure development;cellular metabolic process;regulation of cellular component biogenesis;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process;single-organism intracellular transport;regulation of vacuole organization; 6;4;3;8;3;4;4;2;3;4;4;4;5;2;3;6;7;5;5;4;5;7;3;3;5;3;4;4;4;5;2;4;3;6;4;3;4;4;4;3;3;4;3;1;2;4;3;5;5;5;2;4;4;6;5;8;4;4;4;2;2;4;3;2;5;2;4;2;7;4;6;5;5;6;6;6;4;7;4;6;5;4;5;3;4;4;5;3;4;4;3;5;3;5;3;3;4;4;5;3;2;3;5;4;3;5;5;3;3;3;5;3;4;5;6; GO:0031982;GO:0005773;GO:0016020;GO:0005774;GO:0031902;GO:0031901;GO:0012506;GO:0005794;GO:0098588;GO:0098589;GO:0043231;GO:0005829;GO:0044424;GO:0044425;GO:0098857;GO:0044422;GO:0043229;GO:0043227;GO:0044431;GO:0044437;GO:0030054;GO:0048471;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0044440;GO:0097708;GO:0005770;GO:0010008;GO:0005737;GO:0031090;GO:0031410;GO:0005911;GO:0044464;GO:0005623;GO:0005622;GO:0045121;GO:0098805;GO:0043226;GO:0005575;GO:0005768;GO:0005769; vesicle;vacuole;membrane;vacuolar membrane;late endosome membrane;early endosome membrane;vesicle membrane;Golgi apparatus;bounding membrane of organelle;membrane region;intracellular membrane-bounded organelle;cytosol;intracellular part;membrane part;membrane microdomain;organelle part;intracellular organelle;membrane-bounded organelle;Golgi apparatus part;vacuolar part;cell junction;perinuclear region of cytoplasm;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;endosomal part;intracellular vesicle;late endosome;endosome membrane;cytoplasm;organelle membrane;cytoplasmic vesicle;cell-cell junction;cell part;cell;intracellular;membrane raft;whole membrane;organelle;cellular_component;endosome;early endosome; 4;5;2;4;6;6;4;4;4;3;4;5;3;2;4;2;3;3;4;4;2;5;3;5;3;4;5;4;5;5;4;3;5;3;2;2;3;5;3;2;1;4;5; GO:0043813;GO:1901363;GO:0016740;GO:0097367;GO:0008270;GO:0003674;GO:0005488;GO:1901265;GO:0046914;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0016308;GO:0016301;GO:0016788;GO:0052866;GO:0016773;GO:0097159;GO:0032559;GO:0000285;GO:0032555;GO:0032550;GO:0032553;GO:0016791;GO:0035639;GO:0042578;GO:0000166;GO:0043169;GO:0043167;GO:0046872;GO:0030554;GO:0016772;GO:0036094;GO:0001883;GO:0001882;GO:0016307;GO:0034593;GO:0034595;GO:0003824;GO:0043168; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;heterocyclic compound binding;transferase activity;carbohydrate derivative binding;zinc ion binding;molecular_function;binding;nucleoside phosphate binding;transition metal ion binding;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;1-phosphatidylinositol-4-phosphate 5-kinase activity;kinase activity;hydrolase activity, acting on ester bonds;phosphatidylinositol phosphate phosphatase activity;phosphotransferase activity, alcohol group as acceptor;organic cyclic compound binding;adenyl ribonucleotide binding;1-phosphatidylinositol-3-phosphate 5-kinase activity;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;phosphatase activity;purine ribonucleoside triphosphate binding;phosphoric ester hydrolase activity;nucleotide binding;cation binding;ion binding;metal ion binding;adenyl nucleotide binding;transferase activity, transferring phosphorus-containing groups;small molecule binding;purine nucleoside binding;nucleoside binding;phosphatidylinositol phosphate kinase activity;phosphatidylinositol bisphosphate phosphatase activity;phosphatidylinositol phosphate 5-phosphatase activity;catalytic activity;anion binding; 9;3;3;3;7;1;2;4;6;5;5;6;3;7;5;4;7;5;3;6;7;5;6;4;6;5;5;4;4;3;5;6;4;3;5;4;6;8;8;2;4; K00921 map00562;map04070;map04145;map04810; Inositol phosphate metabolism;Phosphatidylinositol signaling system;Phagosome;Regulation of actin cytoskeleton; IPR027483;IPR002423;IPR011011;IPR002498;IPR013083;IPR000306;IPR027409;IPR017455;IPR011991;IPR000591;IPR027484; Phosphatidylinositol-4-phosphate 5-kinase, C-terminal;Chaperonin Cpn60/TCP-1 family;Zinc finger, FYVE/PHD-type;Phosphatidylinositol-4-phosphate 5-kinase, core;Zinc finger, RING/FYVE/PHD-type;FYVE zinc finger;GroEL-like apical domain;Zinc finger, FYVE-related;Winged helix-turn-helix DNA-binding domain;DEP domain;Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain; nucleus Hs14729948 1163.0 T [T] Signal transduction mechanisms; Q86XP3 ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1 - [DDX42_HUMAN] 0.854 1.063 1.44 0.792 1.016 0.687 0.803386642 0.006033995 0.779527559 0.007761064 1.354656632 0.003056428 0.676181102 0.010844939 GO:0008104;GO:0090304;GO:0006807;GO:0044237;GO:0043170;GO:1901360;GO:0071704;GO:0033036;GO:0006139;GO:0044260;GO:0009987;GO:0006725;GO:0008150;GO:0008152;GO:0034641;GO:0051179;GO:0046483;GO:0016070;GO:0044238;GO:0010501; protein localization;nucleic acid metabolic process;nitrogen compound metabolic process;cellular metabolic process;macromolecule metabolic process;organic cyclic compound metabolic process;organic substance metabolic process;macromolecule localization;nucleobase-containing compound metabolic process;cellular macromolecule metabolic process;cellular process;cellular aromatic compound metabolic process;biological_process;metabolic process;cellular nitrogen compound metabolic process;localization;heterocycle metabolic process;RNA metabolic process;primary metabolic process;RNA secondary structure unwinding; 4;5;3;3;4;4;3;3;4;4;2;4;1;2;4;2;4;5;3;6; GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005575;GO:0016604;GO:0031981;GO:0005634;GO:0016020;GO:0005654;GO:0044451;GO:0016607;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0015030;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;cellular_component;nuclear body;nuclear lumen;nucleus;membrane;nucleoplasm;nucleoplasm part;nuclear speck;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;Cajal body;organelle part; 2;3;3;2;4;1;6;5;5;2;5;5;7;4;3;2;2;3;3;4;4;3;7;2; GO:0003676;GO:0008026;GO:0016787;GO:0035639;GO:0032553;GO:0003674;GO:0016887;GO:0008186;GO:0001883;GO:0001882;GO:0016462;GO:0032555;GO:1901363;GO:1901265;GO:0032549;GO:0032559;GO:0044822;GO:0005524;GO:0030554;GO:0000166;GO:0017111;GO:0004004;GO:0004386;GO:0036094;GO:0003824;GO:0017076;GO:0016818;GO:0097367;GO:0097159;GO:0042623;GO:0016817;GO:0003724;GO:0032550;GO:0003723;GO:0070035;GO:0043167;GO:0043168;GO:0005488; nucleic acid binding;ATP-dependent helicase activity;hydrolase activity;purine ribonucleoside triphosphate binding;ribonucleotide binding;molecular_function;ATPase activity;RNA-dependent ATPase activity;purine nucleoside binding;nucleoside binding;pyrophosphatase activity;purine ribonucleotide binding;heterocyclic compound binding;nucleoside phosphate binding;ribonucleoside binding;adenyl ribonucleotide binding;poly(A) RNA binding;ATP binding;adenyl nucleotide binding;nucleotide binding;nucleoside-triphosphatase activity;ATP-dependent RNA helicase activity;helicase activity;small molecule binding;catalytic activity;purine nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;organic cyclic compound binding;ATPase activity, coupled;hydrolase activity, acting on acid anhydrides;RNA helicase activity;purine ribonucleoside binding;RNA binding;purine NTP-dependent helicase activity;ion binding;anion binding;binding; 4;10;3;5;4;1;8;10;5;4;6;5;3;4;5;6;6;6;6;4;7;10;8;3;2;5;5;3;3;9;4;9;6;5;9;3;4;2; K12835 map03040; Spliceosome; IPR000629;IPR011545;IPR001650;IPR014014;IPR014001;IPR027417; ATP-dependent RNA helicase DEAD-box, conserved site;DEAD/DEAH box helicase domain;Helicase, C-terminal;RNA helicase, DEAD-box type, Q motif;Helicase superfamily 1/2, ATP-binding domain;P-loop containing nucleoside triphosphate hydrolase; nucleus Hs11321632 1450.0 A [A] RNA processing and modification; Q86VM9 Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2 - [ZCH18_HUMAN] 1.051 1.155 0.854 1.062 1.138 0.916 0.90995671 nan 0.933216169 nan 0.739393939 nan 0.804920914 nan GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005575;GO:0031981;GO:0005634;GO:0005654;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cellular_component;nuclear lumen;nucleus;nucleoplasm;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;nuclear part;intracellular part;organelle part; 2;3;3;2;1;5;5;5;4;3;2;2;3;3;4;4;3;2; GO:0003674;GO:0005488;GO:0003676;GO:0043167;GO:1901363;GO:0046872;GO:0043169;GO:0044822;GO:0097159;GO:0003723; molecular_function;binding;nucleic acid binding;ion binding;heterocyclic compound binding;metal ion binding;cation binding;poly(A) RNA binding;organic cyclic compound binding;RNA binding; 1;2;4;3;3;5;4;6;3;5; K13092 IPR000571; Zinc finger, CCCH-type; nucleus Q92820 Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2 - [GGH_HUMAN] 0.936 1.296 0.871 1.276 1.012 0.825 0.722222222 0.038191396 1.260869565 0.041932201 0.672067901 0.007947415 0.815217391 0.890990576 GO:0044281;GO:0010043;GO:1901360;GO:0044710;GO:0006541;GO:0006760;GO:0010038;GO:0043436;GO:0043434;GO:0010035;GO:0010033;GO:0046483;GO:1901564;GO:0006575;GO:0019538;GO:0010243;GO:0006807;GO:0009064;GO:0051186;GO:0042558;GO:0008150;GO:0008152;GO:0046900;GO:1901698;GO:0043603;GO:0097305;GO:0006732;GO:0034641;GO:0044699;GO:0009719;GO:0006508;GO:1901605;GO:0009987;GO:0006725;GO:0006082;GO:0009725;GO:0042493;GO:0043170;GO:0050896;GO:1990267;GO:0019752;GO:0032868;GO:0006520;GO:0071704;GO:0045471;GO:0044763;GO:0042221;GO:1901700;GO:0044238;GO:0044237;GO:1901652; small molecule metabolic process;response to zinc ion;organic cyclic compound metabolic process;single-organism metabolic process;glutamine metabolic process;folic acid-containing compound metabolic process;response to metal ion;oxoacid metabolic process;response to peptide hormone;response to inorganic substance;response to organic substance;heterocycle metabolic process;organonitrogen compound metabolic process;cellular modified amino acid metabolic process;protein metabolic process;response to organonitrogen compound;nitrogen compound metabolic process;glutamine family amino acid metabolic process;cofactor metabolic process;pteridine-containing compound metabolic process;biological_process;metabolic process;tetrahydrofolylpolyglutamate metabolic process;response to nitrogen compound;cellular amide metabolic process;response to alcohol;coenzyme metabolic process;cellular nitrogen compound metabolic process;single-organism process;response to endogenous stimulus;proteolysis;alpha-amino acid metabolic process;cellular process;cellular aromatic compound metabolic process;organic acid metabolic process;response to hormone;response to drug;macromolecule metabolic process;response to stimulus;response to transition metal nanoparticle;carboxylic acid metabolic process;response to insulin;cellular amino acid metabolic process;organic substance metabolic process;response to ethanol;single-organism cellular process;response to chemical;response to oxygen-containing compound;primary metabolic process;cellular metabolic process;response to peptide; 4;5;4;3;7;5;5;5;5;4;4;4;4;4;4;4;3;6;4;5;1;2;6;4;5;5;5;4;2;3;5;5;2;4;4;4;4;4;2;4;6;6;4;3;6;3;3;4;3;3;5; GO:0048770;GO:0031982;GO:0016023;GO:0031988;GO:0043230;GO:0005829;GO:0043231;GO:0044424;GO:0044464;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0097708;GO:0044421;GO:0005773;GO:0044444;GO:0000323;GO:0031410;GO:0005634;GO:0042470;GO:0005623;GO:0005575;GO:0070062;GO:1903561;GO:0005615;GO:0005764;GO:0005576; pigment granule;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;extracellular organelle;cytosol;intracellular membrane-bounded organelle;intracellular part;cell part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;cytoplasm;intracellular vesicle;extracellular region part;vacuole;cytoplasmic part;lytic vacuole;cytoplasmic vesicle;nucleus;melanosome;cell;cellular_component;extracellular exosome;extracellular vesicle;extracellular space;lysosome;extracellular region; 6;4;5;5;3;5;4;3;2;3;3;3;2;4;4;2;5;4;6;5;5;7;2;1;4;3;3;7;2; GO:0008242;GO:0016787;GO:0003674;GO:0003824;GO:0034722;GO:0008238;GO:0008233;GO:0070011; omega peptidase activity;hydrolase activity;molecular_function;catalytic activity;gamma-glutamyl-peptidase activity;exopeptidase activity;peptidase activity;peptidase activity, acting on L-amino acid peptides; 7;3;1;2;8;6;4;5; K01307 map00790; Folate biosynthesis; IPR015527;IPR011697;IPR029062; Peptidase C26, gamma-glutamyl hydrolase;Peptidase C26;Class I glutamine amidotransferase-like; extracellular Hs4503987 664.0 H [H] Coenzyme transport and metabolism; P06276 Cholinesterase OS=Homo sapiens OX=9606 GN=BCHE PE=1 SV=1 - [CHLE_HUMAN] 1.009 1.032 0.99 1.089 1.069 0.844 0.977713178 0.725025531 1.018709074 0.52447139 0.959302326 0.878342509 0.789522919 0.668090476 GO:0007612;GO:0007611;GO:0044281;GO:1901360;GO:0043200;GO:0044710;GO:0048863;GO:0048869;GO:0048519;GO:0003008;GO:0042127;GO:0031960;GO:0051593;GO:0007610;GO:0010033;GO:0046483;GO:0044700;GO:1901564;GO:0044707;GO:0019538;GO:0044708;GO:0010243;GO:0031667;GO:0007154;GO:0098916;GO:0042493;GO:0006807;GO:0050783;GO:0050789;GO:0044267;GO:0014016;GO:0044260;GO:0097164;GO:0065007;GO:0014070;GO:0009308;GO:0050794;GO:0008150;GO:0008152;GO:0050896;GO:0050890;GO:0042439;GO:0006576;GO:0099536;GO:0099537;GO:0030154;GO:0050804;GO:0023057;GO:0034641;GO:0023052;GO:0010648;GO:0023051;GO:0010646;GO:0044699;GO:0009719;GO:0033273;GO:0032502;GO:0008285;GO:0032501;GO:0009987;GO:0006725;GO:0044106;GO:0001101;GO:0043279;GO:0009725;GO:0043170;GO:0048731;GO:0017144;GO:1901698;GO:0048545;GO:0009991;GO:0051384;GO:0007275;GO:0006066;GO:0009820;GO:0033993;GO:0008283;GO:0071704;GO:0050877;GO:0046448;GO:0050805;GO:0009605;GO:0007584;GO:0044767;GO:0044763;GO:0007268;GO:0007267;GO:0042221;GO:0022008;GO:1901700;GO:0044238;GO:0048699;GO:0007399;GO:0019695;GO:0048856;GO:0044237;GO:1901615;GO:0048523; learning;learning or memory;small molecule metabolic process;organic cyclic compound metabolic process;response to amino acid;single-organism metabolic process;stem cell differentiation;cellular developmental process;negative regulation of biological process;system process;regulation of cell proliferation;response to corticosteroid;response to folic acid;behavior;response to organic substance;heterocycle metabolic process;single organism signaling;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;single-organism behavior;response to organonitrogen compound;response to nutrient levels;cell communication;anterograde trans-synaptic signaling;response to drug;nitrogen compound metabolic process;cocaine metabolic process;regulation of biological process;cellular protein metabolic process;neuroblast differentiation;cellular macromolecule metabolic process;ammonium ion metabolic process;biological regulation;response to organic cyclic compound;amine metabolic process;regulation of cellular process;biological_process;metabolic process;response to stimulus;cognition;ethanolamine-containing compound metabolic process;cellular biogenic amine metabolic process;synaptic signaling;trans-synaptic signaling;cell differentiation;modulation of synaptic transmission;negative regulation of signaling;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;regulation of signaling;regulation of cell communication;single-organism process;response to endogenous stimulus;response to vitamin;developmental process;negative regulation of cell proliferation;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;cellular amine metabolic process;response to acid chemical;response to alkaloid;response to hormone;macromolecule metabolic process;system development;drug metabolic process;response to nitrogen compound;response to steroid hormone;response to extracellular stimulus;response to glucocorticoid;multicellular organism development;alcohol metabolic process;alkaloid metabolic process;response to lipid;cell proliferation;organic substance metabolic process;neurological system process;tropane alkaloid metabolic process;negative regulation of synaptic transmission;response to external stimulus;response to nutrient;single-organism developmental process;single-organism cellular process;synaptic transmission;cell-cell signaling;response to chemical;neurogenesis;response to oxygen-containing compound;primary metabolic process;generation of neurons;nervous system development;choline metabolic process;anatomical structure development;cellular metabolic process;organic hydroxy compound metabolic process;negative regulation of cellular process; 5;4;4;4;5;3;6;4;2;3;4;6;6;2;4;4;3;4;3;4;3;4;5;4;7;4;3;5;2;5;7;4;4;2;5;5;3;1;2;2;5;4;6;5;6;5;4;3;4;2;4;3;4;2;3;5;2;4;2;2;4;5;4;5;4;4;4;4;4;5;4;7;4;5;5;5;3;3;4;5;4;3;4;3;3;8;4;3;6;4;3;7;5;5;3;3;4;3; GO:0005783;GO:0005641;GO:0031970;GO:0031974;GO:0016020;GO:0031967;GO:0031975;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0072562;GO:0044432;GO:0012505;GO:0044446;GO:0044444;GO:0005788;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005615;GO:0043226;GO:0005737;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;nuclear envelope lumen;organelle envelope lumen;membrane-enclosed lumen;membrane;organelle envelope;envelope;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;blood microparticle;endoplasmic reticulum part;endomembrane system;intracellular organelle part;cytoplasmic part;endoplasmic reticulum lumen;nucleus;nuclear envelope;cell part;cell;extracellular space;organelle;cytoplasm;cellular_component;intracellular organelle lumen;extracellular region; 4;4;3;2;2;4;3;4;3;4;3;2;2;3;3;3;3;4;3;3;4;5;5;4;2;2;3;2;4;1;4;2; GO:0003674;GO:0005488;GO:0016787;GO:0016788;GO:0003824;GO:0042277;GO:0036094;GO:0003990;GO:0033265;GO:0019899;GO:0043169;GO:0001540;GO:0043167;GO:0070405;GO:0042802;GO:0004104;GO:0033218;GO:0052689;GO:0043178;GO:0005515;GO:0050997; molecular_function;binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;peptide binding;small molecule binding;acetylcholinesterase activity;choline binding;enzyme binding;cation binding;beta-amyloid binding;ion binding;ammonium ion binding;identical protein binding;cholinesterase activity;amide binding;carboxylic ester hydrolase activity;alcohol binding;protein binding;quaternary ammonium group binding; 1;2;3;4;2;4;3;7;4;4;4;5;3;5;4;6;3;5;4;3;3; K01050 IPR019826;IPR000997;IPR002018;IPR019819;IPR029058;IPR014788; Carboxylesterase type B, active site;Cholinesterase;Carboxylesterase, type B;Carboxylesterase type B, conserved site;Alpha/Beta hydrolase fold;Acetylcholinesterase, tetramerisation domain; extracellular Hs4557351 1253.0 T [T] Signal transduction mechanisms; Q8N271 Prominin-2 OS=Homo sapiens OX=9606 GN=PROM2 PE=1 SV=1 - [PROM2_HUMAN] 0.717 0.876 1.627 0.725 1.012 1.349 0.818493151 0.239498868 0.716403162 0.022818039 1.857305936 0.004933388 1.333003953 0.018623429 GO:0019220;GO:0080090;GO:0019222;GO:0051049;GO:0006907;GO:0048261;GO:0031344;GO:0071840;GO:0031346;GO:0048518;GO:0048519;GO:0042325;GO:0051051;GO:0060255;GO:0042327;GO:0016192;GO:0019538;GO:0060627;GO:0009893;GO:0043170;GO:0044267;GO:0044260;GO:0043087;GO:0016043;GO:0065007;GO:0044699;GO:0065009;GO:0051130;GO:0050790;GO:0048550;GO:0006810;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0048259;GO:0051234;GO:0010604;GO:0051336;GO:0006897;GO:0031401;GO:0016310;GO:0072584;GO:0051129;GO:0051128;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0044238;GO:0009987;GO:0032879;GO:0032268;GO:0048548;GO:0006898;GO:0030030;GO:0031325;GO:0031323;GO:0050789;GO:0071704;GO:0006468;GO:0045937;GO:0006464;GO:0051174;GO:0044763;GO:0030100;GO:0051179;GO:2001287;GO:2001286;GO:0001932;GO:0044237;GO:0006796;GO:0006793;GO:0045806;GO:0001934;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;pinocytosis;negative regulation of receptor-mediated endocytosis;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;positive regulation of biological process;negative regulation of biological process;regulation of phosphorylation;negative regulation of transport;regulation of macromolecule metabolic process;positive regulation of phosphorylation;vesicle-mediated transport;protein metabolic process;regulation of vesicle-mediated transport;positive regulation of metabolic process;macromolecule metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of GTPase activity;cellular component organization;biological regulation;single-organism process;regulation of molecular function;positive regulation of cellular component organization;regulation of catalytic activity;negative regulation of pinocytosis;transport;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of receptor-mediated endocytosis;establishment of localization;positive regulation of macromolecule metabolic process;regulation of hydrolase activity;endocytosis;positive regulation of protein modification process;phosphorylation;caveolin-mediated endocytosis;negative regulation of cellular component organization;regulation of cellular component organization;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;primary metabolic process;cellular process;regulation of localization;regulation of cellular protein metabolic process;regulation of pinocytosis;receptor-mediated endocytosis;cell projection organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of biological process;organic substance metabolic process;protein phosphorylation;positive regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;regulation of endocytosis;localization;negative regulation of caveolin-mediated endocytosis;regulation of caveolin-mediated endocytosis;regulation of protein phosphorylation;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of endocytosis;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;4;7;5;5;2;5;2;2;7;3;4;7;5;4;4;3;4;5;4;6;3;2;2;3;4;4;5;4;3;5;5;1;2;6;3;4;5;6;6;6;8;4;4;5;5;5;5;6;3;2;3;5;6;7;4;4;4;2;3;7;6;6;5;3;5;2;6;7;7;3;5;4;4;7;3;3; GO:0031982;GO:0016021;GO:0016020;GO:0098588;GO:0098589;GO:0042995;GO:0071914;GO:0043230;GO:0098858;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0098590;GO:0060170;GO:0005929;GO:0043227;GO:0043226;GO:0031253;GO:0097708;GO:0044444;GO:0044441;GO:0005902;GO:0031226;GO:0031224;GO:0005737;GO:0045177;GO:0031090;GO:0031410;GO:0044459;GO:0016324;GO:0009986;GO:0044393;GO:0016323;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0070062;GO:0098805;GO:0005887;GO:0005886;GO:1903561;GO:0031528;GO:0005575;GO:0005576; vesicle;integral component of membrane;membrane;bounding membrane of organelle;membrane region;cell projection;prominosome;extracellular organelle;actin-based cell projection;intracellular part;membrane part;extracellular region part;organelle part;plasma membrane region;ciliary membrane;cilium;membrane-bounded organelle;organelle;cell projection membrane;intracellular vesicle;cytoplasmic part;ciliary part;microvillus;intrinsic component of plasma membrane;intrinsic component of membrane;cytoplasm;apical part of cell;organelle membrane;cytoplasmic vesicle;plasma membrane part;apical plasma membrane;cell surface;microspike;basolateral plasma membrane;cell projection part;cell part;cell;intracellular;cell periphery;extracellular exosome;whole membrane;integral component of plasma membrane;plasma membrane;extracellular vesicle;microvillus membrane;cellular_component;extracellular region; 4;4;2;4;3;3;4;3;4;3;2;2;2;4;4;3;3;2;4;4;4;3;5;4;3;4;3;3;5;3;4;3;4;4;3;2;2;3;3;4;3;4;3;3;5;1;2; GO:0032934;GO:0005496;GO:0015485;GO:0003674;GO:0005488;GO:0036094;GO:0097159;GO:0043178;GO:0008289; sterol binding;steroid binding;cholesterol binding;molecular_function;binding;small molecule binding;organic cyclic compound binding;alcohol binding;lipid binding; 5;4;6;1;2;3;3;4;3; K15602 IPR008795; Prominin; plasma membrane Hs21389623 1692.0 R [R] General function prediction only; Q969D9 Thymic stromal lymphopoietin OS=Homo sapiens OX=9606 GN=TSLP PE=1 SV=1 - [TSLP_HUMAN] 0.956 0.956 1.267 0.966 1.058 0.753 1 nan 0.913043478 nan 1.325313808 nan 0.711720227 nan GO:0005575;GO:0005576;GO:0005615;GO:0044421; cellular_component;extracellular region;extracellular space;extracellular region part; 1;2;3;2; K05436 map04060;map04630; Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway; IPR029189; Thymic stromal lymphopoietin; extracellular Q6ZMR5 Transmembrane protease serine 11A OS=Homo sapiens OX=9606 GN=TMPRSS11A PE=1 SV=1 - [TM11A_HUMAN] 1.069 1.044 0.995 0.971 1.128 0.84 1.02394636 0.95844107 0.860815603 0.014270672 0.953065134 0.11729708 0.744680851 0.050789399 GO:0007049;GO:0044699;GO:0009987;GO:0044763;GO:0008150; cell cycle;single-organism process;cellular process;single-organism cellular process;biological_process; 4;2;2;3;1; GO:0031224;GO:0071944;GO:0031226;GO:0016021;GO:0016020;GO:0005576;GO:0044425;GO:0044459;GO:0005887;GO:0005886;GO:0044464;GO:0005623;GO:0005575; intrinsic component of membrane;cell periphery;intrinsic component of plasma membrane;integral component of membrane;membrane;extracellular region;membrane part;plasma membrane part;integral component of plasma membrane;plasma membrane;cell part;cell;cellular_component; 3;3;4;4;2;2;2;3;4;3;2;2;1; GO:0004252;GO:0004175;GO:0003674;GO:0008233;GO:0008236;GO:0016787;GO:0017171;GO:0003824;GO:0070011; serine-type endopeptidase activity;endopeptidase activity;molecular_function;peptidase activity;serine-type peptidase activity;hydrolase activity;serine hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides; 6;6;1;4;5;3;4;2;5; K09750 IPR001254;IPR000082;IPR017329;IPR009003;IPR018114;IPR033116;IPR001314; Serine proteases, trypsin domain;SEA domain;Peptidase S1A, HAT/DESC1;Peptidase S1, PA clan;Serine proteases, trypsin family, histidine active site;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; Golgi apparatus Hs17446387 692.0 E [E] Amino acid transport and metabolism; Q9NRR4 Ribonuclease 3 OS=Homo sapiens OX=9606 GN=DROSHA PE=1 SV=2 - [RNC_HUMAN] 1.025 1.081 0.936 1.102 1.004 1.273 0.948196115 nan 1.097609562 nan 0.86586494 nan 1.267928287 nan GO:0080090;GO:0019222;GO:0030422;GO:0031050;GO:0031053;GO:0031054;GO:1901360;GO:1901361;GO:0044710;GO:0010605;GO:0010604;GO:0043207;GO:0010608;GO:0071840;GO:0009617;GO:0043043;GO:0040029;GO:0016458;GO:0048518;GO:0048519;GO:0051704;GO:0034470;GO:0010467;GO:0060255;GO:0019439;GO:0050830;GO:0006401;GO:0009607;GO:0051707;GO:0010033;GO:0046483;GO:1901564;GO:0009605;GO:1901566;GO:0019538;GO:0034661;GO:0043331;GO:0016441;GO:0009892;GO:0034645;GO:0009890;GO:0010629;GO:0006807;GO:0042742;GO:0050829;GO:0034660;GO:0009057;GO:0050789;GO:0070918;GO:1901576;GO:1901575;GO:0044265;GO:0044260;GO:0071359;GO:0042254;GO:0065007;GO:0014070;GO:0009889;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0034655;GO:0046700;GO:0016070;GO:0016072;GO:0044271;GO:1901698;GO:1901699;GO:0010556;GO:0006518;GO:0010558;GO:0051171;GO:0090501;GO:0044248;GO:0044249;GO:0034641;GO:0070887;GO:0044699;GO:0009893;GO:0006139;GO:0051248;GO:0051246;GO:0022613;GO:0009987;GO:0006725;GO:0034249;GO:0034248;GO:0098542;GO:0044270;GO:0090502;GO:0043604;GO:0032269;GO:0032268;GO:0043603;GO:0071407;GO:0051252;GO:0043170;GO:0010628;GO:0017148;GO:0050896;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0090305;GO:0016075;GO:0010586;GO:2000112;GO:2000113;GO:0071704;GO:0071310;GO:0016246;GO:0010468;GO:0044267;GO:0019219;GO:2000628;GO:0009058;GO:0009059;GO:0044763;GO:0031047;GO:0051172;GO:0042221;GO:0009056;GO:0044238;GO:0035194;GO:0035195;GO:0035196;GO:0044237;GO:0044085;GO:0048523;GO:0006417;GO:0006412;GO:0006396; regulation of primary metabolic process;regulation of metabolic process;production of siRNA involved in RNA interference;dsRNA fragmentation;primary miRNA processing;pre-miRNA processing;organic cyclic compound metabolic process;organic cyclic compound catabolic process;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;response to external biotic stimulus;posttranscriptional regulation of gene expression;cellular component organization or biogenesis;response to bacterium;peptide biosynthetic process;regulation of gene expression, epigenetic;gene silencing;positive regulation of biological process;negative regulation of biological process;multi-organism process;ncRNA processing;gene expression;regulation of macromolecule metabolic process;aromatic compound catabolic process;defense response to Gram-positive bacterium;RNA catabolic process;response to biotic stimulus;response to other organism;response to organic substance;heterocycle metabolic process;organonitrogen compound metabolic process;response to external stimulus;organonitrogen compound biosynthetic process;protein metabolic process;ncRNA catabolic process;response to dsRNA;posttranscriptional gene silencing;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;negative regulation of gene expression;nitrogen compound metabolic process;defense response to bacterium;defense response to Gram-negative bacterium;ncRNA metabolic process;macromolecule catabolic process;regulation of biological process;production of small RNA involved in gene silencing by RNA;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;cellular response to dsRNA;ribosome biogenesis;biological regulation;response to organic cyclic compound;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;nucleobase-containing compound catabolic process;heterocycle catabolic process;RNA metabolic process;rRNA metabolic process;cellular nitrogen compound biosynthetic process;response to nitrogen compound;cellular response to nitrogen compound;regulation of macromolecule biosynthetic process;peptide metabolic process;negative regulation of macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;RNA phosphodiester bond hydrolysis;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular response to chemical stimulus;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;regulation of protein metabolic process;ribonucleoprotein complex biogenesis;cellular process;cellular aromatic compound metabolic process;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;defense response to other organism;cellular nitrogen compound catabolic process;RNA phosphodiester bond hydrolysis, endonucleolytic;amide biosynthetic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;cellular response to organic cyclic compound;regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of gene expression;negative regulation of translation;response to stimulus;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;rRNA catabolic process;miRNA metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;RNA interference;regulation of gene expression;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of miRNA metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;gene silencing by RNA;negative regulation of nitrogen compound metabolic process;response to chemical;catabolic process;primary metabolic process;posttranscriptional gene silencing by RNA;gene silencing by miRNA;production of miRNAs involved in gene silencing by miRNA;cellular metabolic process;cellular component biogenesis;negative regulation of cellular process;regulation of translation;translation;RNA processing; 4;3;6;4;7;7;4;5;3;4;4;4;6;2;4;6;6;4;2;2;2;7;5;4;5;6;6;3;3;4;4;4;3;5;4;7;5;5;3;5;4;5;3;5;6;6;5;2;5;4;4;5;4;6;5;2;5;4;3;3;4;3;1;2;5;5;5;7;5;4;5;5;5;5;4;6;4;4;4;4;2;3;4;5;5;4;2;4;5;5;4;5;7;6;5;5;5;6;5;4;5;6;2;5;5;4;4;5;6;8;7;6;6;3;5;7;5;5;5;6;3;5;3;5;4;3;3;3;6;7;6;3;3;3;6;6;6; GO:1903095;GO:0031974;GO:1902494;GO:1902555;GO:0043234;GO:0043233;GO:0043231;GO:0044422;GO:0043232;GO:0005622;GO:0043227;GO:0005654;GO:0044428;GO:0044424;GO:0031981;GO:0044446;GO:0070877;GO:0005730;GO:0005634;GO:0032991;GO:0044464;GO:0043229;GO:0005623;GO:0043226;GO:0043228;GO:0005575;GO:0070013; ribonuclease III complex;membrane-enclosed lumen;catalytic complex;endoribonuclease complex;protein complex;organelle lumen;intracellular membrane-bounded organelle;organelle part;intracellular non-membrane-bounded organelle;intracellular;membrane-bounded organelle;nucleoplasm;nuclear part;intracellular part;nuclear lumen;intracellular organelle part;microprocessor complex;nucleolus;nucleus;macromolecular complex;cell part;intracellular organelle;cell;organelle;non-membrane-bounded organelle;cellular_component;intracellular organelle lumen; 6;2;4;5;3;3;4;2;4;3;3;5;4;3;5;3;5;5;5;2;2;3;2;2;3;1;4; GO:1901363;GO:0070878;GO:0016893;GO:0016891;GO:0097367;GO:0004519;GO:0003674;GO:0003676;GO:0004540;GO:0003725;GO:0016787;GO:0043169;GO:0016788;GO:0003824;GO:0097159;GO:0004521;GO:0004525;GO:0043167;GO:0042802;GO:0042803;GO:0032296;GO:0044822;GO:0008289;GO:0004518;GO:0003723;GO:0005515;GO:0005488;GO:0001530;GO:0046983;GO:0046872; heterocyclic compound binding;primary miRNA binding;endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters;endoribonuclease activity, producing 5'-phosphomonoesters;carbohydrate derivative binding;endonuclease activity;molecular_function;nucleic acid binding;ribonuclease activity;double-stranded RNA binding;hydrolase activity;cation binding;hydrolase activity, acting on ester bonds;catalytic activity;organic cyclic compound binding;endoribonuclease activity;ribonuclease III activity;ion binding;identical protein binding;protein homodimerization activity;double-stranded RNA-specific ribonuclease activity;poly(A) RNA binding;lipid binding;nuclease activity;RNA binding;protein binding;binding;lipopolysaccharide binding;protein dimerization activity;metal ion binding; 3;6;7;8;3;6;1;4;6;6;3;4;4;2;3;7;8;3;4;5;7;6;3;5;5;3;2;4;4;5; K03685 map03008;map05205; Ribosome biogenesis in eukaryotes;Proteoglycans in cancer; IPR011907;IPR000999;IPR014720; Ribonuclease III;Ribonuclease III domain;Double-stranded RNA-binding domain; nucleus Hs21359822 2852.0 A [A] RNA processing and modification; P02671 Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2 - [FIBA_HUMAN] 0.849 0.805 1.318 1 0.809 1.507 1.054658385 0.968914465 1.236093943 3.10E-12 1.637267081 4.02E-26 1.862793572 2.00E-11 GO:0090087;GO:0007599;GO:0051046;GO:0051047;GO:0051049;GO:0007596;GO:0051716;GO:0019730;GO:0043207;GO:0019731;GO:0000165;GO:0031100;GO:0060548;GO:0042325;GO:0042327;GO:0009607;GO:0009605;GO:0019538;GO:1902531;GO:0009892;GO:0009893;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0000904;GO:0000902;GO:0006887;GO:0070741;GO:1990638;GO:0070201;GO:0098602;GO:0098609;GO:0043410;GO:1903524;GO:1903522;GO:0042060;GO:0002526;GO:0050714;GO:0071345;GO:0036211;GO:0009967;GO:0097305;GO:0051128;GO:0014072;GO:0014070;GO:1904019;GO:1900026;GO:1900024;GO:0060284;GO:0050878;GO:0046883;GO:0098542;GO:0046887;GO:0045921;GO:0060341;GO:0097190;GO:0097191;GO:0022407;GO:0061041;GO:0001889;GO:0061045;GO:0008219;GO:0007275;GO:0022409;GO:0032355;GO:0033993;GO:0043067;GO:0043066;GO:0043062;GO:0080184;GO:0043069;GO:0006468;GO:0045087;GO:0006461;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:1901700;GO:0048856;GO:0009914;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0034116;GO:0034114;GO:0034113;GO:0034446;GO:0007160;GO:0003013;GO:0007165;GO:0007166;GO:0003018;GO:0044710;GO:0045785;GO:0033036;GO:0051050;GO:0010038;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:0061008;GO:0042310;GO:0044267;GO:0010646;GO:0044260;GO:0043412;GO:0043408;GO:0006915;GO:0050793;GO:0050794;GO:0051239;GO:0051234;GO:1990643;GO:0044057;GO:0097421;GO:0050896;GO:0043152;GO:0010562;GO:1902042;GO:0033594;GO:1902041;GO:0032102;GO:0032101;GO:0051246;GO:1903530;GO:0070887;GO:1903532;GO:0044699;GO:0032880;GO:0051248;GO:0051240;GO:0051241;GO:0031099;GO:0051247;GO:0010769;GO:0031399;GO:1903034;GO:1903035;GO:0043278;GO:0043279;GO:0048731;GO:0048732;GO:0070374;GO:0070372;GO:0070371;GO:0016337;GO:0043933;GO:0034622;GO:0035556;GO:0046898;GO:0033595;GO:0045937;GO:0010810;GO:0010811;GO:0010817;GO:0043627;GO:0042221;GO:0043623;GO:0044238;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:0007267;GO:2001234;GO:2001236;GO:2001237;GO:0019220;GO:0019222;GO:2001233;GO:0048585;GO:0048584;GO:0048583;GO:0019229;GO:0008104;GO:0090066;GO:0071840;GO:0009968;GO:0009966;GO:0048869;GO:0046879;GO:0048513;GO:0010720;GO:0048518;GO:0048519;GO:2000258;GO:0031589;GO:2000257;GO:0045184;GO:0003008;GO:0044700;GO:0016192;GO:0044707;GO:0010243;GO:0002376;GO:0022604;GO:0022607;GO:0022603;GO:0043170;GO:0042981;GO:0045055;GO:0009306;GO:1900046;GO:1900047;GO:1904035;GO:1904036;GO:0035150;GO:0034097;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0006954;GO:0006955;GO:0006959;GO:0050818;GO:0050819;GO:0010604;GO:0046903;GO:0072577;GO:0051604;GO:0006953;GO:0080134;GO:0031401;GO:0001775;GO:0030155;GO:0030154;GO:0015833;GO:1902533;GO:1904951;GO:0008625;GO:0032270;GO:0006508;GO:0017157;GO:0032502;GO:0032501;GO:0009987;GO:2000351;GO:2000352;GO:0060627;GO:0016485;GO:0032879;GO:0051258;GO:0071407;GO:0010770;GO:0048545;GO:0002576;GO:0031639;GO:0031638;GO:0032989;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0023061;GO:0051174;GO:0051179;GO:1902578;GO:0051641;GO:0071822;GO:1901654;GO:0045907;GO:0080090;GO:0023014;GO:0010605;GO:0009617;GO:0009611;GO:0060255;GO:0051592;GO:0090276;GO:0090277;GO:0030168;GO:0030198;GO:0030193;GO:0030195;GO:2000260;GO:2000261;GO:0032940;GO:0042742;GO:0050708;GO:0071354;GO:0016043;GO:0070271;GO:0065003;GO:0065007;GO:0065008;GO:0051130;GO:0009719;GO:0008015;GO:0048468;GO:0050880;GO:0008150;GO:0008152;GO:0042730;GO:1901698;GO:0016310;GO:0023056;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0010647;GO:0009653;GO:0042886;GO:0022610;GO:0045597;GO:0045595;GO:0032268;GO:0051094;GO:0009725;GO:0031325;GO:0031323;GO:0010941;GO:0072377;GO:0072376;GO:0072378;GO:0010467;GO:0034109;GO:0007155;GO:0007154;GO:0070527;GO:0044085;GO:0002250;GO:0015031;GO:0001932;GO:0001934; regulation of peptide transport;hemostasis;regulation of secretion;positive regulation of secretion;regulation of transport;blood coagulation;cellular response to stimulus;antimicrobial humoral response;response to external biotic stimulus;antibacterial humoral response;MAPK cascade;organ regeneration;negative regulation of cell death;regulation of phosphorylation;positive regulation of phosphorylation;response to biotic stimulus;response to external stimulus;protein metabolic process;regulation of intracellular signal transduction;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;cell morphogenesis involved in differentiation;cell morphogenesis;exocytosis;response to interleukin-6;response to granulocyte colony-stimulating factor;regulation of establishment of protein localization;single organism cell adhesion;cell-cell adhesion;positive regulation of MAPK cascade;positive regulation of blood circulation;regulation of blood circulation;wound healing;acute inflammatory response;positive regulation of protein secretion;cellular response to cytokine stimulus;protein modification process;positive regulation of signal transduction;response to alcohol;regulation of cellular component organization;response to isoquinoline alkaloid;response to organic cyclic compound;epithelial cell apoptotic process;positive regulation of substrate adhesion-dependent cell spreading;regulation of substrate adhesion-dependent cell spreading;regulation of cell development;regulation of body fluid levels;regulation of hormone secretion;defense response to other organism;positive regulation of hormone secretion;positive regulation of exocytosis;regulation of cellular localization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;regulation of cell-cell adhesion;regulation of wound healing;liver development;negative regulation of wound healing;cell death;multicellular organism development;positive regulation of cell-cell adhesion;response to estradiol;response to lipid;regulation of programmed cell death;negative regulation of apoptotic process;extracellular structure organization;response to phenylpropanoid;negative regulation of programmed cell death;protein phosphorylation;innate immune response;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;response to oxygen-containing compound;anatomical structure development;hormone transport;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;positive regulation of heterotypic cell-cell adhesion;regulation of heterotypic cell-cell adhesion;heterotypic cell-cell adhesion;substrate adhesion-dependent cell spreading;cell-matrix adhesion;circulatory system process;signal transduction;cell surface receptor signaling pathway;vascular process in circulatory system;single-organism metabolic process;positive regulation of cell adhesion;macromolecule localization;positive regulation of transport;response to metal ion;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;hepaticobiliary system development;vasoconstriction;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;macromolecule modification;regulation of MAPK cascade;apoptotic process;regulation of developmental process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;cellular response to granulocyte colony-stimulating factor;regulation of system process;liver regeneration;response to stimulus;induction of bacterial agglutination;positive regulation of phosphorus metabolic process;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;response to hydroxyisoflavone;regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of response to external stimulus;regulation of response to external stimulus;regulation of protein metabolic process;regulation of secretion by cell;cellular response to chemical stimulus;positive regulation of secretion by cell;single-organism process;regulation of protein localization;negative regulation of protein metabolic process;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regeneration;positive regulation of protein metabolic process;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;regulation of response to wounding;negative regulation of response to wounding;response to morphine;response to alkaloid;system development;gland development;positive regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;single organismal cell-cell adhesion;macromolecular complex subunit organization;cellular macromolecular complex assembly;intracellular signal transduction;response to cycloheximide;response to genistein;positive regulation of phosphate metabolic process;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;regulation of hormone levels;response to estrogen;response to chemical;cellular protein complex assembly;primary metabolic process;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;cell-cell signaling;negative regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of vasoconstriction;protein localization;regulation of anatomical structure size;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;hormone secretion;animal organ development;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;negative regulation of protein activation cascade;cell-substrate adhesion;regulation of protein activation cascade;establishment of protein localization;system process;single organism signaling;vesicle-mediated transport;single-multicellular organism process;response to organonitrogen compound;immune system process;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;macromolecule metabolic process;regulation of apoptotic process;regulated exocytosis;protein secretion;regulation of hemostasis;negative regulation of hemostasis;regulation of epithelial cell apoptotic process;negative regulation of epithelial cell apoptotic process;regulation of tube size;response to cytokine;transport;defense response;programmed cell death;response to stress;coagulation;inflammatory response;immune response;humoral immune response;regulation of coagulation;negative regulation of coagulation;positive regulation of macromolecule metabolic process;secretion;endothelial cell apoptotic process;protein maturation;acute-phase response;regulation of response to stress;positive regulation of protein modification process;cell activation;regulation of cell adhesion;cell differentiation;peptide transport;positive regulation of intracellular signal transduction;positive regulation of establishment of protein localization;extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of cellular protein metabolic process;proteolysis;regulation of exocytosis;developmental process;multicellular organismal process;cellular process;regulation of endothelial cell apoptotic process;negative regulation of endothelial cell apoptotic process;regulation of vesicle-mediated transport;protein processing;regulation of localization;protein polymerization;cellular response to organic cyclic compound;positive regulation of cell morphogenesis involved in differentiation;response to steroid hormone;platelet degranulation;plasminogen activation;zymogen activation;cellular component morphogenesis;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;signal release;regulation of phosphorus metabolic process;localization;single-organism localization;cellular localization;protein complex subunit organization;response to ketone;positive regulation of vasoconstriction;regulation of primary metabolic process;signal transduction by protein phosphorylation;negative regulation of macromolecule metabolic process;response to bacterium;response to wounding;regulation of macromolecule metabolic process;response to calcium ion;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;platelet activation;extracellular matrix organization;regulation of blood coagulation;negative regulation of blood coagulation;regulation of blood coagulation, common pathway;negative regulation of blood coagulation, common pathway;secretion by cell;defense response to bacterium;regulation of protein secretion;cellular response to interleukin-6;cellular component organization;protein complex biogenesis;macromolecular complex assembly;biological regulation;regulation of biological quality;positive regulation of cellular component organization;response to endogenous stimulus;blood circulation;cell development;regulation of blood vessel size;biological_process;metabolic process;fibrinolysis;response to nitrogen compound;phosphorylation;positive regulation of signaling;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;amide transport;biological adhesion;positive regulation of cell differentiation;regulation of cell differentiation;regulation of cellular protein metabolic process;positive regulation of developmental process;response to hormone;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of cell death;blood coagulation, common pathway;protein activation cascade;blood coagulation, fibrin clot formation;gene expression;homotypic cell-cell adhesion;cell adhesion;cell communication;platelet aggregation;cellular component biogenesis;adaptive immune response;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 5;5;5;4;4;5;3;4;4;5;5;5;4;7;7;3;3;4;5;3;3;4;5;2;7;5;5;5;6;6;5;3;4;6;4;5;5;6;5;6;5;4;5;4;6;5;7;5;5;5;4;4;4;4;5;4;5;6;5;6;5;5;4;4;5;6;5;5;6;4;6;5;7;4;5;6;3;4;3;4;3;5;5;4;3;3;6;6;5;4;5;4;4;5;5;3;4;3;3;5;4;3;4;2;5;7;5;4;4;5;6;6;3;3;3;3;7;4;6;2;6;5;7;6;7;4;4;5;5;4;4;2;4;5;3;3;4;5;6;6;5;4;7;5;4;4;7;7;6;4;4;6;5;5;7;6;5;5;4;6;3;6;3;6;6;5;3;4;5;6;6;6;3;5;3;3;3;6;4;4;2;4;4;4;6;4;5;2;2;4;4;4;4;3;3;5;3;4;2;5;4;4;4;6;6;5;4;4;7;7;5;5;4;4;5;3;4;5;3;4;4;4;4;5;8;5;7;4;6;4;4;5;6;5;3;7;5;5;5;2;2;2;8;8;4;6;3;7;6;5;5;7;8;7;4;5;3;5;5;5;5;2;3;3;5;5;5;4;4;4;4;4;4;6;5;5;5;5;5;5;5;5;4;5;6;7;3;4;5;2;3;4;3;5;4;6;1;2;6;4;6;3;3;2;4;3;4;3;5;2;4;4;5;3;4;4;4;4;4;3;4;5;5;3;4;6;3;4;5;7;7; GO:0034774;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0016023;GO:0016020;GO:0099503;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0060205;GO:0072562;GO:0044433;GO:0030141;GO:0031091;GO:0031093;GO:0043227;GO:0005783;GO:0031974;GO:0043229;GO:0043226;GO:0012505;GO:0031983;GO:0044446;GO:0044444;GO:0005938;GO:0005737;GO:0009986;GO:0098552;GO:0099568;GO:0031982;GO:0031988;GO:0005791;GO:0097708;GO:0031410;GO:0044459;GO:0005623;GO:0005622;GO:0005576;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005577; secretory granule lumen;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;cell part;cell periphery;extracellular space;extracellular exosome;cytoplasmic, membrane-bounded vesicle;membrane;secretory vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytoplasmic membrane-bounded vesicle lumen;blood microparticle;cytoplasmic vesicle part;secretory granule;platelet alpha granule;platelet alpha granule lumen;membrane-bounded organelle;endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;organelle;endomembrane system;vesicle lumen;intracellular organelle part;cytoplasmic part;cell cortex;cytoplasm;cell surface;side of membrane;cytoplasmic region;vesicle;membrane-bounded vesicle;rough endoplasmic reticulum;intracellular vesicle;cytoplasmic vesicle;plasma membrane part;cell;intracellular;extracellular region;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;fibrinogen complex; 5;3;2;2;2;4;2;3;3;4;5;2;6;3;3;4;3;5;3;4;4;5;6;3;4;2;3;2;3;4;3;4;4;4;3;3;5;4;5;5;4;5;3;2;3;2;3;3;2;1;3; GO:0005488;GO:0046872;GO:0003674;GO:0043169;GO:0043167;GO:0005198; binding;metal ion binding;molecular_function;cation binding;ion binding;structural molecule activity; 2;5;1;4;3;2; K03903 map04610;map04611; Complement and coagulation cascades;Platelet activation; IPR014716;IPR014715;IPR012290;IPR020837;IPR002181;IPR021996; Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, alpha/beta/gamma chain, coiled coil domain;Fibrinogen, conserved site;Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Fibrinogen alpha C domain; extracellular P57764 Gasdermin-D OS=Homo sapiens OX=9606 GN=GSDMD PE=1 SV=1 - [GSDMD_HUMAN] 1.057 0.656 1.517 1.139 0.791 0.768 1.611280488 nan 1.439949431 nan 2.3125 nan 0.970922882 nan GO:0008104;GO:0051046;GO:0051047;GO:0051049;GO:0051716;GO:0048518;GO:0033036;GO:0032652;GO:0051050;GO:0045184;GO:0031668;GO:0044707;GO:0009605;GO:0002376;GO:0032731;GO:0032732;GO:0032940;GO:0051222;GO:0051223;GO:0050789;GO:0050708;GO:0050704;GO:0050706;GO:0050707;GO:0050701;GO:0050702;GO:0065007;GO:0070201;GO:0009306;GO:0006810;GO:0050794;GO:0006952;GO:0012501;GO:0006950;GO:0008150;GO:0051239;GO:0006955;GO:0051234;GO:0046903;GO:0050716;GO:0050715;GO:0050714;GO:0050896;GO:0050718;GO:0006954;GO:1903530;GO:1903532;GO:1904951;GO:0044699;GO:0032880;GO:0051240;GO:0032501;GO:0032612;GO:0009987;GO:0070269;GO:0032879;GO:0001816;GO:0001817;GO:0001819;GO:0009991;GO:0060341;GO:0071496;GO:0008219;GO:0050663;GO:0032651;GO:0071702;GO:0032611;GO:0045087;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0015031;GO:0048522; protein localization;regulation of secretion;positive regulation of secretion;regulation of transport;cellular response to stimulus;positive regulation of biological process;macromolecule localization;regulation of interleukin-1 production;positive regulation of transport;establishment of protein localization;cellular response to extracellular stimulus;single-multicellular organism process;response to external stimulus;immune system process;positive regulation of interleukin-1 beta production;positive regulation of interleukin-1 production;secretion by cell;positive regulation of protein transport;regulation of protein transport;regulation of biological process;regulation of protein secretion;regulation of interleukin-1 secretion;regulation of interleukin-1 beta secretion;regulation of cytokine secretion;interleukin-1 secretion;interleukin-1 beta secretion;biological regulation;regulation of establishment of protein localization;protein secretion;transport;regulation of cellular process;defense response;programmed cell death;response to stress;biological_process;regulation of multicellular organismal process;immune response;establishment of localization;secretion;positive regulation of interleukin-1 secretion;positive regulation of cytokine secretion;positive regulation of protein secretion;response to stimulus;positive regulation of interleukin-1 beta secretion;inflammatory response;regulation of secretion by cell;positive regulation of secretion by cell;positive regulation of establishment of protein localization;single-organism process;regulation of protein localization;positive regulation of multicellular organismal process;multicellular organismal process;interleukin-1 production;cellular process;pyroptosis;regulation of localization;cytokine production;regulation of cytokine production;positive regulation of cytokine production;response to extracellular stimulus;regulation of cellular localization;cellular response to external stimulus;cell death;cytokine secretion;regulation of interleukin-1 beta production;organic substance transport;interleukin-1 beta production;innate immune response;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;cellular localization;protein transport;positive regulation of cellular process; 4;5;4;4;3;2;3;5;3;4;4;3;3;2;6;5;4;4;5;2;6;6;7;5;6;7;2;5;5;4;3;4;5;3;1;3;3;3;5;6;5;5;2;7;5;5;4;3;2;4;3;2;5;2;6;3;4;4;4;4;4;4;4;5;6;5;6;4;4;3;4;2;3;3;5;3; GO:0031974;GO:0031981;GO:0072559;GO:0061702;GO:0043231;GO:0043234;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043227;GO:0005654;GO:0044446;GO:0044444;GO:0044445;GO:0005634;GO:0005737;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;NLRP3 inflammasome complex;inflammasome complex;intracellular membrane-bounded organelle;protein complex;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;cytosolic part;nucleus;cytoplasm;cell part;intracellular organelle;cell;intracellular;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;5;5;4;4;3;3;5;4;3;2;3;5;3;4;5;5;4;2;3;2;3;2;2;1;4; K20917 IPR007677; Gasdermin; cytosol P02675 Fibrinogen beta chain OS=Homo sapiens OX=9606 GN=FGB PE=1 SV=2 - [FIBB_HUMAN] 0.784 0.93 1.145 1.129 0.808 1.702 0.843010753 1 1.397277228 0.001896749 1.231182796 0.040119985 2.106435644 0.014592644 GO:0090087;GO:0007599;GO:0051046;GO:0051047;GO:0051049;GO:0007596;GO:0044321;GO:0044320;GO:0051716;GO:0019730;GO:0043207;GO:0019731;GO:0000165;GO:0060548;GO:0042325;GO:0042327;GO:0009607;GO:0009605;GO:0019538;GO:0009893;GO:0051222;GO:0051223;GO:0050789;GO:0030072;GO:0000904;GO:0000902;GO:0006887;GO:0070201;GO:0098602;GO:0098609;GO:0043410;GO:0043412;GO:1903522;GO:0042060;GO:0050714;GO:0071345;GO:0071347;GO:0009967;GO:0001775;GO:0051128;GO:1904019;GO:1900026;GO:1900024;GO:0060284;GO:0050878;GO:0046883;GO:0098542;GO:0046887;GO:0045921;GO:0060341;GO:0097190;GO:0097191;GO:0022407;GO:0061041;GO:0061045;GO:0008219;GO:0022409;GO:0043067;GO:0043066;GO:0043062;GO:0043069;GO:0006468;GO:0045087;GO:0006461;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0048856;GO:0009914;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0034116;GO:0034114;GO:0034113;GO:0034446;GO:0007160;GO:0003013;GO:0007165;GO:0007166;GO:0003018;GO:0044710;GO:0045785;GO:0070271;GO:0033036;GO:0051050;GO:0010038;GO:0010035;GO:0051707;GO:0010033;GO:0051704;GO:1903532;GO:0042310;GO:0044267;GO:0010646;GO:0044260;GO:0043408;GO:0006915;GO:0050793;GO:0050794;GO:0051239;GO:0051234;GO:0044057;GO:0050896;GO:0043152;GO:0051240;GO:1902042;GO:1902041;GO:0032102;GO:0032101;GO:1903530;GO:0070887;GO:0044699;GO:0032880;GO:0010562;GO:0051241;GO:0051246;GO:0051247;GO:0010769;GO:0031399;GO:1903034;GO:1903035;GO:0070374;GO:0070372;GO:0070371;GO:0016337;GO:0043933;GO:0034622;GO:0035556;GO:0045937;GO:0010810;GO:0010811;GO:0010817;GO:0007267;GO:0042221;GO:0043623;GO:0044238;GO:0002790;GO:0002791;GO:0002793;GO:0044237;GO:2001234;GO:2001236;GO:2001237;GO:0019220;GO:0019222;GO:2001233;GO:0048585;GO:0048584;GO:0048583;GO:0019229;GO:0008104;GO:0090066;GO:0071840;GO:0009968;GO:0009966;GO:0048869;GO:0046879;GO:0010720;GO:0048518;GO:0048519;GO:0031589;GO:0045184;GO:0003008;GO:0044700;GO:0016192;GO:0044707;GO:0002376;GO:0022604;GO:0022607;GO:0022603;GO:0042981;GO:0045055;GO:0009306;GO:1900046;GO:1900047;GO:1904035;GO:1904036;GO:0050880;GO:0035150;GO:0034097;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0006955;GO:1902533;GO:1902531;GO:0050818;GO:0050819;GO:0010604;GO:0046903;GO:0072577;GO:0051604;GO:0080134;GO:0031401;GO:1903524;GO:0030155;GO:0030154;GO:0015833;GO:1904951;GO:0008625;GO:0032270;GO:0006508;GO:0017157;GO:0071495;GO:0032501;GO:0009987;GO:2000351;GO:2000352;GO:0060627;GO:0032870;GO:0016485;GO:0032879;GO:0051258;GO:0010770;GO:0002576;GO:0031639;GO:0031638;GO:0006959;GO:0032989;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0023061;GO:0051174;GO:0051179;GO:1902578;GO:0051641;GO:0045907;GO:0080090;GO:0023014;GO:0009617;GO:0009611;GO:0060255;GO:0051592;GO:0090276;GO:0090277;GO:0030168;GO:0030198;GO:0030193;GO:0030195;GO:0032940;GO:0042742;GO:0050708;GO:0016043;GO:0065003;GO:0065007;GO:0065008;GO:0051130;GO:0009719;GO:0008015;GO:0048468;GO:0036211;GO:0008150;GO:0008152;GO:0042730;GO:0016310;GO:0023056;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0010647;GO:0009653;GO:0042886;GO:0022610;GO:0045597;GO:0045595;GO:0032268;GO:0051094;GO:0009725;GO:0043170;GO:0032502;GO:0031325;GO:0031323;GO:0010941;GO:0071822;GO:0072376;GO:0072378;GO:0070555;GO:0010467;GO:0034109;GO:0007155;GO:0007154;GO:0070527;GO:0044085;GO:0002250;GO:0015031;GO:0001932;GO:0001934; regulation of peptide transport;hemostasis;regulation of secretion;positive regulation of secretion;regulation of transport;blood coagulation;response to leptin;cellular response to leptin stimulus;cellular response to stimulus;antimicrobial humoral response;response to external biotic stimulus;antibacterial humoral response;MAPK cascade;negative regulation of cell death;regulation of phosphorylation;positive regulation of phosphorylation;response to biotic stimulus;response to external stimulus;protein metabolic process;positive regulation of metabolic process;positive regulation of protein transport;regulation of protein transport;regulation of biological process;peptide hormone secretion;cell morphogenesis involved in differentiation;cell morphogenesis;exocytosis;regulation of establishment of protein localization;single organism cell adhesion;cell-cell adhesion;positive regulation of MAPK cascade;macromolecule modification;regulation of blood circulation;wound healing;positive regulation of protein secretion;cellular response to cytokine stimulus;cellular response to interleukin-1;positive regulation of signal transduction;cell activation;regulation of cellular component organization;epithelial cell apoptotic process;positive regulation of substrate adhesion-dependent cell spreading;regulation of substrate adhesion-dependent cell spreading;regulation of cell development;regulation of body fluid levels;regulation of hormone secretion;defense response to other organism;positive regulation of hormone secretion;positive regulation of exocytosis;regulation of cellular localization;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;regulation of cell-cell adhesion;regulation of wound healing;negative regulation of wound healing;cell death;positive regulation of cell-cell adhesion;regulation of programmed cell death;negative regulation of apoptotic process;extracellular structure organization;negative regulation of programmed cell death;protein phosphorylation;innate immune response;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;anatomical structure development;hormone transport;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;positive regulation of heterotypic cell-cell adhesion;regulation of heterotypic cell-cell adhesion;heterotypic cell-cell adhesion;substrate adhesion-dependent cell spreading;cell-matrix adhesion;circulatory system process;signal transduction;cell surface receptor signaling pathway;vascular process in circulatory system;single-organism metabolic process;positive regulation of cell adhesion;protein complex biogenesis;macromolecule localization;positive regulation of transport;response to metal ion;response to inorganic substance;response to other organism;response to organic substance;multi-organism process;positive regulation of secretion by cell;vasoconstriction;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;regulation of MAPK cascade;apoptotic process;regulation of developmental process;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of system process;response to stimulus;induction of bacterial agglutination;positive regulation of multicellular organismal process;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of response to external stimulus;regulation of response to external stimulus;regulation of secretion by cell;cellular response to chemical stimulus;single-organism process;regulation of protein localization;positive regulation of phosphorus metabolic process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;regulation of response to wounding;negative regulation of response to wounding;positive regulation of ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;single organismal cell-cell adhesion;macromolecular complex subunit organization;cellular macromolecular complex assembly;intracellular signal transduction;positive regulation of phosphate metabolic process;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;regulation of hormone levels;cell-cell signaling;response to chemical;cellular protein complex assembly;primary metabolic process;peptide secretion;regulation of peptide secretion;positive regulation of peptide secretion;cellular metabolic process;negative regulation of apoptotic signaling pathway;regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;regulation of phosphate metabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;regulation of vasoconstriction;protein localization;regulation of anatomical structure size;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;hormone secretion;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;cell-substrate adhesion;establishment of protein localization;system process;single organism signaling;vesicle-mediated transport;single-multicellular organism process;immune system process;regulation of cell morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;regulation of apoptotic process;regulated exocytosis;protein secretion;regulation of hemostasis;negative regulation of hemostasis;regulation of epithelial cell apoptotic process;negative regulation of epithelial cell apoptotic process;regulation of blood vessel size;regulation of tube size;response to cytokine;transport;defense response;programmed cell death;response to stress;coagulation;immune response;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of coagulation;negative regulation of coagulation;positive regulation of macromolecule metabolic process;secretion;endothelial cell apoptotic process;protein maturation;regulation of response to stress;positive regulation of protein modification process;positive regulation of blood circulation;regulation of cell adhesion;cell differentiation;peptide transport;positive regulation of establishment of protein localization;extrinsic apoptotic signaling pathway via death domain receptors;positive regulation of cellular protein metabolic process;proteolysis;regulation of exocytosis;cellular response to endogenous stimulus;multicellular organismal process;cellular process;regulation of endothelial cell apoptotic process;negative regulation of endothelial cell apoptotic process;regulation of vesicle-mediated transport;cellular response to hormone stimulus;protein processing;regulation of localization;protein polymerization;positive regulation of cell morphogenesis involved in differentiation;platelet degranulation;plasminogen activation;zymogen activation;humoral immune response;cellular component morphogenesis;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;signal release;regulation of phosphorus metabolic process;localization;single-organism localization;cellular localization;positive regulation of vasoconstriction;regulation of primary metabolic process;signal transduction by protein phosphorylation;response to bacterium;response to wounding;regulation of macromolecule metabolic process;response to calcium ion;regulation of peptide hormone secretion;positive regulation of peptide hormone secretion;platelet activation;extracellular matrix organization;regulation of blood coagulation;negative regulation of blood coagulation;secretion by cell;defense response to bacterium;regulation of protein secretion;cellular component organization;macromolecular complex assembly;biological regulation;regulation of biological quality;positive regulation of cellular component organization;response to endogenous stimulus;blood circulation;cell development;protein modification process;biological_process;metabolic process;fibrinolysis;phosphorylation;positive regulation of signaling;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;amide transport;biological adhesion;positive regulation of cell differentiation;regulation of cell differentiation;regulation of cellular protein metabolic process;positive regulation of developmental process;response to hormone;macromolecule metabolic process;developmental process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of cell death;protein complex subunit organization;protein activation cascade;blood coagulation, fibrin clot formation;response to interleukin-1;gene expression;homotypic cell-cell adhesion;cell adhesion;cell communication;platelet aggregation;cellular component biogenesis;adaptive immune response;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 5;5;5;4;4;5;5;6;3;4;4;5;5;4;7;7;3;3;4;3;4;5;2;7;5;5;5;5;3;4;6;5;5;5;5;6;7;4;4;4;7;5;5;5;4;4;4;4;5;4;5;6;5;6;5;4;5;5;6;4;5;7;4;5;6;3;4;3;3;5;5;4;3;3;6;6;5;4;5;4;4;5;5;3;4;4;3;3;5;4;3;4;2;4;7;5;4;4;6;6;3;3;3;3;4;2;6;3;7;7;4;4;5;4;2;4;5;3;5;5;6;6;5;4;7;7;6;4;4;6;5;6;5;5;4;4;3;6;3;6;6;5;3;5;6;6;6;3;5;3;3;3;6;4;4;2;4;4;4;6;5;2;2;4;4;3;3;5;3;2;5;4;4;6;6;5;4;4;7;7;6;5;5;4;4;5;3;4;3;5;5;4;4;4;5;8;5;4;6;4;4;5;6;3;7;5;5;5;4;2;2;8;8;4;5;6;3;7;5;7;8;7;4;4;5;3;5;5;5;5;2;3;3;5;4;4;4;4;4;6;5;5;5;5;5;5;4;5;6;3;5;2;3;4;3;5;4;5;1;2;6;6;3;3;2;4;3;4;3;5;2;4;4;5;3;4;4;2;4;4;4;5;3;4;6;5;5;3;4;6;3;4;5;7;7; GO:0034774;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0016023;GO:0099503;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0072562;GO:0044433;GO:0030141;GO:0060205;GO:0031091;GO:0031093;GO:0043227;GO:0031974;GO:0043229;GO:0005622;GO:0043226;GO:0012505;GO:0044446;GO:0044444;GO:0005938;GO:0016020;GO:0005737;GO:0009986;GO:0098552;GO:0099568;GO:0031983;GO:0031982;GO:0031988;GO:0097708;GO:0031410;GO:0044459;GO:0005623;GO:0005576;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005577; secretory granule lumen;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;cell part;cell periphery;extracellular space;extracellular exosome;cytoplasmic, membrane-bounded vesicle;secretory vesicle;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;blood microparticle;cytoplasmic vesicle part;secretory granule;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;platelet alpha granule lumen;membrane-bounded organelle;membrane-enclosed lumen;intracellular organelle;intracellular;organelle;endomembrane system;intracellular organelle part;cytoplasmic part;cell cortex;membrane;cytoplasm;cell surface;side of membrane;cytoplasmic region;vesicle lumen;vesicle;membrane-bounded vesicle;intracellular vesicle;cytoplasmic vesicle;plasma membrane part;cell;extracellular region;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;fibrinogen complex; 5;3;2;2;2;4;2;3;3;4;5;6;3;3;4;3;3;4;4;5;5;6;3;2;3;3;2;3;3;4;4;2;4;3;3;5;4;4;5;4;5;3;2;2;3;3;2;1;3; GO:0005488;GO:0005515;GO:0003674;GO:0051087;GO:0005198; binding;protein binding;molecular_function;chaperone binding;structural molecule activity; 2;3;1;4;2; K03904 map04610;map04611; Complement and coagulation cascades;Platelet activation; IPR012290;IPR002181;IPR014715;IPR020837;IPR014716; Fibrinogen, alpha/beta/gamma chain, coiled coil domain;Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, conserved site;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1; extracellular Hs11761631 1030.0 R [R] General function prediction only; P46109 Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1 - [CRKL_HUMAN] 1.061 0.893 1.215 0.954 0.931 0.98 1.188129899 5.49E-07 1.024704619 0.245268529 1.360582307 6.67E-14 1.052631579 0.313612569 GO:0019220;GO:0080090;GO:0019222;GO:0048584;GO:0048583;GO:0032147;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0023014;GO:0051716;GO:0010604;GO:0009966;GO:0009967;GO:0000165;GO:0070848;GO:0048513;GO:0044093;GO:0048518;GO:0060017;GO:0038179;GO:0060255;GO:0045859;GO:0035270;GO:0042221;GO:0003002;GO:0010033;GO:0042325;GO:0044700;GO:0042327;GO:0044707;GO:0019538;GO:0002376;GO:0033554;GO:0009893;GO:0033674;GO:0008284;GO:0035556;GO:0071900;GO:0050789;GO:0044267;GO:0009653;GO:0051347;GO:0044260;GO:0001568;GO:0043549;GO:0065007;GO:0043085;GO:0065009;GO:0009887;GO:0050790;GO:0044710;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0048011;GO:1902533;GO:1902531;GO:0044767;GO:0009952;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0016310;GO:0031098;GO:0023056;GO:0043405;GO:0023052;GO:0070887;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0043408;GO:0007254;GO:0007264;GO:0042127;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0002520;GO:0032502;GO:0032501;GO:0007507;GO:0009987;GO:0032268;GO:0071363;GO:0043170;GO:0048731;GO:0048732;GO:0045860;GO:0000186;GO:0001944;GO:0031325;GO:0031323;GO:0007275;GO:0007389;GO:0008283;GO:0071704;GO:0071310;GO:0048538;GO:0048534;GO:0006468;GO:0045937;GO:0006464;GO:0051174;GO:0051403;GO:0044763;GO:0007154;GO:0007265;GO:0044238;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;signal transduction by protein phosphorylation;cellular response to stimulus;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;response to growth factor;animal organ development;positive regulation of molecular function;positive regulation of biological process;parathyroid gland development;neurotrophin signaling pathway;regulation of macromolecule metabolic process;regulation of protein kinase activity;endocrine system development;response to chemical;regionalization;response to organic substance;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;single-multicellular organism process;protein metabolic process;immune system process;cellular response to stress;positive regulation of metabolic process;positive regulation of kinase activity;positive regulation of cell proliferation;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cellular macromolecule metabolic process;blood vessel development;regulation of kinase activity;biological regulation;positive regulation of catalytic activity;regulation of molecular function;organ morphogenesis;regulation of catalytic activity;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;metabolic process;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;single-organism developmental process;anterior/posterior pattern specification;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;phosphorylation;stress-activated protein kinase signaling cascade;positive regulation of signaling;regulation of MAP kinase activity;signaling;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MAPK cascade;JNK cascade;small GTPase mediated signal transduction;regulation of cell proliferation;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;immune system development;developmental process;multicellular organismal process;heart development;cellular process;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;macromolecule metabolic process;system development;gland development;positive regulation of protein kinase activity;activation of MAPKK activity;vasculature development;positive regulation of cellular metabolic process;regulation of cellular metabolic process;multicellular organism development;pattern specification process;cell proliferation;organic substance metabolic process;cellular response to organic substance;thymus development;hematopoietic or lymphoid organ development;protein phosphorylation;positive regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;stress-activated MAPK cascade;single-organism cellular process;cell communication;Ras protein signal transduction;primary metabolic process;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;4;3;3;3;9;5;5;4;5;6;7;4;3;4;4;4;5;5;4;4;2;5;6;4;7;5;3;5;4;7;3;7;3;4;2;4;3;7;4;5;8;2;5;3;6;4;4;6;2;5;3;4;4;3;3;6;5;5;1;2;7;5;5;3;6;2;6;3;5;6;5;3;7;2;4;3;4;4;2;6;7;6;4;5;5;5;5;6;3;2;2;4;2;5;6;4;4;4;8;7;5;4;4;4;4;3;3;5;5;4;7;6;6;5;6;3;4;7;3;3;3;5;4;7;7;3; GO:0043230;GO:0043231;GO:0005829;GO:0044424;GO:0044421;GO:0043229;GO:0043227;GO:0012505;GO:0031982;GO:0005773;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0070062;GO:0043226;GO:0005622;GO:1903561;GO:0005575;GO:0005576;GO:0005768; extracellular organelle;intracellular membrane-bounded organelle;cytosol;intracellular part;extracellular region part;intracellular organelle;membrane-bounded organelle;endomembrane system;vesicle;vacuole;cytoplasmic part;cytoplasm;cell part;cell;extracellular exosome;organelle;intracellular;extracellular vesicle;cellular_component;extracellular region;endosome; 3;4;5;3;2;3;3;3;4;5;4;4;2;2;4;2;3;3;1;2;4; GO:1901363;GO:0005070;GO:0060090;GO:0003674;GO:0005488;GO:0003676;GO:0030674;GO:0097159;GO:0044822;GO:0003723;GO:0005515;GO:0004871;GO:0035591; heterocyclic compound binding;SH3/SH2 adaptor activity;binding, bridging;molecular_function;binding;nucleic acid binding;protein binding, bridging;organic cyclic compound binding;poly(A) RNA binding;RNA binding;protein binding;signal transducer activity;signaling adaptor activity; 3;5;3;1;2;4;4;3;6;5;3;2;4; K04438 map04010;map04012;map04015;map04062;map04510;map04666;map04722;map04810;map04910;map05100;map05131;map05200;map05206;map05211;map05220; MAPK signaling pathway;ErbB signaling pathway;Rap1 signaling pathway;Chemokine signaling pathway;Focal adhesion;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;Bacterial invasion of epithelial cells;Shigellosis;Pathways in cancer;MicroRNAs in cancer;Renal cell carcinoma;Chronic myeloid leukemia; IPR001452;IPR011511;IPR000980;IPR035458;IPR035457; SH3 domain;Variant SH3 domain;SH2 domain;CRK, C-terminal SH3 domain;CRK, N-terminal SH3 domain; nucleus Hs4885153 631.0 T [T] Signal transduction mechanisms; P02679 Fibrinogen gamma chain OS=Homo sapiens OX=9606 GN=FGG PE=1 SV=3 - [FIBG_HUMAN] 0.802 0.967 1.119 1.023 0.882 1.566 0.829369183 0.23616537 1.159863946 0.759601195 1.157187177 0.316800932 1.775510204 0.107575527 GO:2001234;GO:0034116;GO:2001236;GO:2001237;GO:0034113;GO:0080090;GO:0051046;GO:2001233;GO:0051049;GO:0048585;GO:0007596;GO:0048583;GO:0019229;GO:0032101;GO:0007160;GO:0032268;GO:0034109;GO:0034114;GO:0090276;GO:0007165;GO:0007166;GO:0003018;GO:0007599;GO:0006796;GO:0032989;GO:1904036;GO:0071840;GO:0065003;GO:0051716;GO:0009968;GO:0045785;GO:0009966;GO:0048869;GO:0051047;GO:0000165;GO:0009611;GO:0008104;GO:1900047;GO:0010467;GO:0010720;GO:0016310;GO:0048518;GO:0048519;GO:0042325;GO:0031589;GO:0048584;GO:0051050;GO:0060255;GO:0060548;GO:0071702;GO:0042221;GO:0090277;GO:0010038;GO:0010035;GO:0030168;GO:0003008;GO:0044700;GO:0042327;GO:0016192;GO:0044707;GO:0019538;GO:0045055;GO:0048468;GO:0003013;GO:0006464;GO:0010648;GO:0022604;GO:0022607;GO:0009893;GO:0022603;GO:1903532;GO:0044085;GO:0032940;GO:0042310;GO:0051222;GO:0043170;GO:0042981;GO:0050789;GO:0030072;GO:0044267;GO:0009653;GO:0050708;GO:0000902;GO:0044260;GO:0006887;GO:0043410;GO:0010562;GO:0016043;GO:0090066;GO:0008015;GO:1900046;GO:0030198;GO:0065007;GO:0023014;GO:0010811;GO:0065008;GO:0035150;GO:0070201;GO:0098602;GO:0098609;GO:0006810;GO:0044710;GO:0042060;GO:0050794;GO:0045907;GO:0012501;GO:0006950;GO:0050817;GO:0008150;GO:0051239;GO:1902533;GO:0051234;GO:0050818;GO:0050819;GO:0010604;GO:0051174;GO:0046903;GO:0072577;GO:0051604;GO:0050714;GO:0043412;GO:0050896;GO:0031401;GO:1903524;GO:0002793;GO:0036211;GO:0030195;GO:0009967;GO:1903522;GO:0042886;GO:1900024;GO:1902042;GO:1902041;GO:0032102;GO:0008152;GO:0070271;GO:0001775;GO:0030193;GO:0030155;GO:0030154;GO:0051128;GO:0023056;GO:0023057;GO:0015833;GO:0023052;GO:1903530;GO:1902531;GO:0023051;GO:0051592;GO:0010647;GO:0010646;GO:0044699;GO:0032880;GO:1904019;GO:0008625;GO:0044057;GO:1900026;GO:0051240;GO:0051241;GO:0051246;GO:0051247;GO:0060284;GO:0010769;GO:0031399;GO:0006508;GO:0022610;GO:1903035;GO:0017157;GO:0032502;GO:0032501;GO:0050878;GO:0045184;GO:0031323;GO:0009987;GO:0043408;GO:2000351;GO:2000352;GO:0060627;GO:0045597;GO:0045595;GO:0046883;GO:0046887;GO:0016485;GO:0032879;GO:0006793;GO:0006461;GO:0033036;GO:0042730;GO:0090087;GO:0051094;GO:0034446;GO:1903034;GO:0051258;GO:0010770;GO:0070374;GO:0051130;GO:0080134;GO:0070371;GO:0070372;GO:0045921;GO:0016337;GO:0060341;GO:0032270;GO:0043933;GO:0031325;GO:0034622;GO:0097190;GO:0097191;GO:0022407;GO:0061041;GO:0061045;GO:0008219;GO:0010941;GO:0035556;GO:0019220;GO:0022409;GO:0051223;GO:0071822;GO:0072376;GO:0002576;GO:0070527;GO:0031639;GO:0031638;GO:0071705;GO:0071704;GO:0043067;GO:0043066;GO:0043062;GO:0043069;GO:0009605;GO:0006468;GO:1904035;GO:0045937;GO:0046879;GO:0010810;GO:0050880;GO:0006915;GO:0023061;GO:0010817;GO:0044767;GO:0044765;GO:0000904;GO:0044763;GO:0007155;GO:0007154;GO:0019222;GO:0043623;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0002790;GO:0002791;GO:0048856;GO:0050793;GO:0044237;GO:0009914;GO:0007267;GO:0072378;GO:0015031;GO:1904951;GO:0001932;GO:0009306;GO:0001934;GO:0048523;GO:0048522; negative regulation of apoptotic signaling pathway;positive regulation of heterotypic cell-cell adhesion;regulation of extrinsic apoptotic signaling pathway;negative regulation of extrinsic apoptotic signaling pathway;heterotypic cell-cell adhesion;regulation of primary metabolic process;regulation of secretion;regulation of apoptotic signaling pathway;regulation of transport;negative regulation of response to stimulus;blood coagulation;regulation of response to stimulus;regulation of vasoconstriction;regulation of response to external stimulus;cell-matrix adhesion;regulation of cellular protein metabolic process;homotypic cell-cell adhesion;regulation of heterotypic cell-cell adhesion;regulation of peptide hormone secretion;signal transduction;cell surface receptor signaling pathway;vascular process in circulatory system;hemostasis;phosphate-containing compound metabolic process;cellular component morphogenesis;negative regulation of epithelial cell apoptotic process;cellular component organization or biogenesis;macromolecular complex assembly;cellular response to stimulus;negative regulation of signal transduction;positive regulation of cell adhesion;regulation of signal transduction;cellular developmental process;positive regulation of secretion;MAPK cascade;response to wounding;protein localization;negative regulation of hemostasis;gene expression;positive regulation of cell development;phosphorylation;positive regulation of biological process;negative regulation of biological process;regulation of phosphorylation;cell-substrate adhesion;positive regulation of response to stimulus;positive regulation of transport;regulation of macromolecule metabolic process;negative regulation of cell death;organic substance transport;response to chemical;positive regulation of peptide hormone secretion;response to metal ion;response to inorganic substance;platelet activation;system process;single organism signaling;positive regulation of phosphorylation;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;regulated exocytosis;cell development;circulatory system process;cellular protein modification process;negative regulation of cell communication;regulation of cell morphogenesis;cellular component assembly;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;positive regulation of secretion by cell;cellular component biogenesis;secretion by cell;vasoconstriction;positive regulation of protein transport;macromolecule metabolic process;regulation of apoptotic process;regulation of biological process;peptide hormone secretion;cellular protein metabolic process;anatomical structure morphogenesis;regulation of protein secretion;cell morphogenesis;cellular macromolecule metabolic process;exocytosis;positive regulation of MAPK cascade;positive regulation of phosphorus metabolic process;cellular component organization;regulation of anatomical structure size;blood circulation;regulation of hemostasis;extracellular matrix organization;biological regulation;signal transduction by protein phosphorylation;positive regulation of cell-substrate adhesion;regulation of biological quality;regulation of tube size;regulation of establishment of protein localization;single organism cell adhesion;cell-cell adhesion;transport;single-organism metabolic process;wound healing;regulation of cellular process;positive regulation of vasoconstriction;programmed cell death;response to stress;coagulation;biological_process;regulation of multicellular organismal process;positive regulation of intracellular signal transduction;establishment of localization;regulation of coagulation;negative regulation of coagulation;positive regulation of macromolecule metabolic process;regulation of phosphorus metabolic process;secretion;endothelial cell apoptotic process;protein maturation;positive regulation of protein secretion;macromolecule modification;response to stimulus;positive regulation of protein modification process;positive regulation of blood circulation;positive regulation of peptide secretion;protein modification process;negative regulation of blood coagulation;positive regulation of signal transduction;regulation of blood circulation;amide transport;regulation of substrate adhesion-dependent cell spreading;negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;regulation of extrinsic apoptotic signaling pathway via death domain receptors;negative regulation of response to external stimulus;metabolic process;protein complex biogenesis;cell activation;regulation of blood coagulation;regulation of cell adhesion;cell differentiation;regulation of cellular component organization;positive regulation of signaling;negative regulation of signaling;peptide transport;signaling;regulation of secretion by cell;regulation of intracellular signal transduction;regulation of signaling;response to calcium ion;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of protein localization;epithelial cell apoptotic process;extrinsic apoptotic signaling pathway via death domain receptors;regulation of system process;positive regulation of substrate adhesion-dependent cell spreading;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell development;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;proteolysis;biological adhesion;negative regulation of response to wounding;regulation of exocytosis;developmental process;multicellular organismal process;regulation of body fluid levels;establishment of protein localization;regulation of cellular metabolic process;cellular process;regulation of MAPK cascade;regulation of endothelial cell apoptotic process;negative regulation of endothelial cell apoptotic process;regulation of vesicle-mediated transport;positive regulation of cell differentiation;regulation of cell differentiation;regulation of hormone secretion;positive regulation of hormone secretion;protein processing;regulation of localization;phosphorus metabolic process;protein complex assembly;macromolecule localization;fibrinolysis;regulation of peptide transport;positive regulation of developmental process;substrate adhesion-dependent cell spreading;regulation of response to wounding;protein polymerization;positive regulation of cell morphogenesis involved in differentiation;positive regulation of ERK1 and ERK2 cascade;positive regulation of cellular component organization;regulation of response to stress;ERK1 and ERK2 cascade;regulation of ERK1 and ERK2 cascade;positive regulation of exocytosis;single organismal cell-cell adhesion;regulation of cellular localization;positive regulation of cellular protein metabolic process;macromolecular complex subunit organization;positive regulation of cellular metabolic process;cellular macromolecular complex assembly;apoptotic signaling pathway;extrinsic apoptotic signaling pathway;regulation of cell-cell adhesion;regulation of wound healing;negative regulation of wound healing;cell death;regulation of cell death;intracellular signal transduction;regulation of phosphate metabolic process;positive regulation of cell-cell adhesion;regulation of protein transport;protein complex subunit organization;protein activation cascade;platelet degranulation;platelet aggregation;plasminogen activation;zymogen activation;nitrogen compound transport;organic substance metabolic process;regulation of programmed cell death;negative regulation of apoptotic process;extracellular structure organization;negative regulation of programmed cell death;response to external stimulus;protein phosphorylation;regulation of epithelial cell apoptotic process;positive regulation of phosphate metabolic process;hormone secretion;regulation of cell-substrate adhesion;regulation of blood vessel size;apoptotic process;signal release;regulation of hormone levels;single-organism developmental process;single-organism transport;cell morphogenesis involved in differentiation;single-organism cellular process;cell adhesion;cell communication;regulation of metabolic process;cellular protein complex assembly;localization;single-organism localization;cellular localization;primary metabolic process;peptide secretion;regulation of peptide secretion;anatomical structure development;regulation of developmental process;cellular metabolic process;hormone transport;cell-cell signaling;blood coagulation, fibrin clot formation;protein transport;positive regulation of establishment of protein localization;regulation of protein phosphorylation;protein secretion;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 5;6;6;6;5;4;5;5;4;3;5;3;6;4;5;5;5;6;5;4;5;5;5;5;4;7;2;5;3;4;4;4;4;4;5;4;4;4;5;5;6;2;2;7;4;3;3;4;4;5;3;5;5;4;5;3;3;7;5;3;4;6;4;4;6;4;5;4;3;4;4;3;4;7;4;4;6;2;7;5;3;6;5;4;5;6;5;3;4;5;4;5;2;4;5;3;5;5;3;4;4;3;5;3;5;5;3;4;1;3;5;3;4;4;4;5;5;8;5;5;5;2;6;4;5;5;5;4;5;5;5;7;7;4;2;4;4;5;4;5;4;3;3;6;2;5;5;3;6;4;4;2;4;7;7;4;5;3;3;5;5;5;6;6;5;2;4;5;2;2;4;4;4;2;6;8;8;4;4;4;4;4;6;3;4;5;3;6;5;3;4;5;7;5;7;4;4;6;7;5;4;4;5;4;4;6;5;6;5;6;5;4;4;5;6;5;5;5;3;7;6;8;7;5;3;5;6;4;5;3;7;7;6;6;5;6;6;5;4;3;4;5;3;3;4;3;6;2;3;3;3;6;6;3;3;3;5;4;4;5;3;7;5;7;3;3; GO:0031974;GO:0031983;GO:0031982;GO:0031988;GO:0099503;GO:0060205;GO:0034774;GO:0043234;GO:0043230;GO:0043233;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0009897;GO:0044433;GO:0030141;GO:0012505;GO:0031093;GO:0044446;GO:0016023;GO:0044444;GO:0099568;GO:0097708;GO:0005737;GO:0031091;GO:0031410;GO:0005615;GO:0044459;GO:0009986;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0072562;GO:0071944;GO:0098552;GO:0016020;GO:0070062;GO:0043227;GO:0043226;GO:0005938;GO:0005886;GO:1903561;GO:0032991;GO:0005575;GO:0005577;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;membrane-bounded vesicle;secretory vesicle;cytoplasmic membrane-bounded vesicle lumen;secretory granule lumen;protein complex;extracellular organelle;organelle lumen;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;external side of plasma membrane;cytoplasmic vesicle part;secretory granule;endomembrane system;platelet alpha granule lumen;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;cytoplasmic region;intracellular vesicle;cytoplasm;platelet alpha granule;cytoplasmic vesicle;extracellular space;plasma membrane part;cell surface;cell part;intracellular organelle;cell;intracellular;blood microparticle;cell periphery;side of membrane;membrane;extracellular exosome;membrane-bounded organelle;organelle;cell cortex;plasma membrane;extracellular vesicle;macromolecular complex;cellular_component;fibrinogen complex;extracellular region; 2;4;4;5;6;5;5;3;3;3;4;3;2;2;2;4;4;4;3;6;3;5;4;5;4;4;5;5;3;3;3;2;3;2;3;3;3;3;2;4;3;2;4;3;3;2;1;3;2; GO:0050839;GO:0046872;GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005198;GO:0005515;GO:0005102; cell adhesion molecule binding;metal ion binding;molecular_function;binding;cation binding;ion binding;structural molecule activity;protein binding;receptor binding; 4;5;1;2;4;3;2;3;4; K03905 map04610;map04611;map05150; Complement and coagulation cascades;Platelet activation;Staphylococcus aureus infection; IPR002181;IPR014716;IPR014715;IPR012290;IPR020837; Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, alpha/beta/gamma chain, coiled coil domain;Fibrinogen, conserved site; mitochondria Hs11761633 950.0 R [R] General function prediction only; Q9NQG5 Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1 - [RPR1B_HUMAN] 1.196 0.943 0.859 0.965 1.192 1.145 1.268292683 nan 0.809563758 nan 0.910922587 nan 0.96057047 nan GO:0080090;GO:0019222;GO:0006470;GO:1901362;GO:1901360;GO:0010604;GO:0048518;GO:0042127;GO:0060255;GO:2001141;GO:0046483;GO:0019538;GO:0019438;GO:0009893;GO:0009891;GO:0006807;GO:0010628;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0007049;GO:0006366;GO:0018130;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0016311;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0010564;GO:0008284;GO:0008283;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0070940;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0045944;GO:1903508;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0022402;GO:2000112;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0044267;GO:0019219;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044238;GO:0051726;GO:0044237;GO:0006796;GO:0006793;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of macromolecule metabolic process;positive regulation of biological process;regulation of cell proliferation;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;protein metabolic process;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;positive regulation of gene expression;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;cell cycle;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;dephosphorylation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;regulation of cell cycle process;positive regulation of cell proliferation;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;dephosphorylation of RNA polymerase II C-terminal domain;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of transcription from RNA polymerase II promoter;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;primary metabolic process;regulation of cell cycle;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;positive regulation of cellular process; 4;3;7;5;4;4;2;4;4;6;4;4;5;3;4;3;5;2;7;4;4;2;4;7;5;4;3;5;5;1;2;5;5;5;6;5;5;6;6;6;4;4;5;2;4;5;4;3;2;4;7;6;8;5;5;4;6;7;7;5;5;4;4;5;4;6;3;5;7;5;5;5;5;6;3;5;3;4;4;3;4;3;5;4;3; GO:0031974;GO:0016591;GO:0030880;GO:0031981;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0000428;GO:0043229;GO:0005622;GO:0043227;GO:0005856;GO:0005654;GO:0044430;GO:0055029;GO:0044446;GO:0043226;GO:0005737;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:0043228;GO:0005813;GO:0061695;GO:0005815;GO:0015630;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;DNA-directed RNA polymerase II, holoenzyme;RNA polymerase complex;nuclear lumen;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;DNA-directed RNA polymerase complex;intracellular organelle;intracellular;membrane-bounded organelle;cytoskeleton;nucleoplasm;cytoskeletal part;nuclear DNA-directed RNA polymerase complex;intracellular organelle part;organelle;cytoplasm;nucleus;nucleoplasm part;cell part;cell;non-membrane-bounded organelle;centrosome;transferase complex, transferring phosphorus-containing groups;microtubule organizing center;microtubule cytoskeleton;macromolecular complex;cellular_component;intracellular organelle lumen; 2;6;4;5;4;5;3;4;4;3;4;3;2;5;3;3;3;5;5;4;5;3;2;4;5;5;2;2;3;5;6;5;6;2;1;4; GO:0044877;GO:0000993;GO:0005488;GO:0001098;GO:0001099;GO:0019899;GO:0032403;GO:0043175;GO:0005515;GO:0003674;GO:0070063; macromolecular complex binding;RNA polymerase II core binding;binding;basal transcription machinery binding;basal RNA polymerase II transcription machinery binding;enzyme binding;protein complex binding;RNA polymerase core enzyme binding;protein binding;molecular_function;RNA polymerase binding; 3;5;2;4;5;4;4;6;3;1;5; K15559 IPR006569;IPR032337;IPR008942;IPR006903; CID domain;Cell-cycle alteration and expression-elevated protein in tumour;ENTH/VHS;RNA polymerase II-binding domain; nucleus Hs11034845 661.0 A [A] RNA processing and modification; A0A1B0GVG6 Testis-expressed protein 54 OS=Homo sapiens OX=9606 GN=TEX54 PE=2 SV=1 - [TEX54_HUMAN] 0.993 1.133 0.959 1.043 1.009 1.274 0.876434245 nan 1.033696729 nan 0.846425419 nan 1.262636274 nan nucleus O43439 Protein CBFA2T2 OS=Homo sapiens OX=9606 GN=CBFA2T2 PE=1 SV=1 - [MTG8R_HUMAN] 0.572 1.2 1.557 0.912 0.567 1.939 0.476666667 0.073962259 1.608465608 0.055490537 1.2975 0.232891882 3.419753086 0.022602302 GO:0080090;GO:0019222;GO:0048468;GO:2000113;GO:1901362;GO:0031344;GO:1901360;GO:0031346;GO:0010605;GO:0010604;GO:0048869;GO:0045665;GO:0045664;GO:0045666;GO:0010720;GO:0010721;GO:0048518;GO:0048519;GO:0060255;GO:0006366;GO:0010977;GO:0010976;GO:0010975;GO:2001141;GO:0046483;GO:0044707;GO:0010629;GO:0019438;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0006807;GO:0031175;GO:0097659;GO:1901576;GO:0044260;GO:0031345;GO:0016043;GO:0065007;GO:0071840;GO:0018130;GO:0051130;GO:0050767;GO:0050793;GO:0009889;GO:0009888;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:1902679;GO:0044271;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0051240;GO:0032774;GO:0030154;GO:0051129;GO:0051128;GO:0044249;GO:0034641;GO:0060284;GO:0034645;GO:0051960;GO:0044699;GO:0006139;GO:0051241;GO:0050768;GO:0050769;GO:0031327;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045597;GO:0045596;GO:0045595;GO:0045892;GO:0045893;GO:0051239;GO:0051093;GO:0051094;GO:0051253;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0045944;GO:0048731;GO:1903508;GO:0031328;GO:0030030;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0007275;GO:0051962;GO:2000112;GO:0051961;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0030855;GO:0048666;GO:0060429;GO:0045935;GO:0045934;GO:0030182;GO:0019219;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0022008;GO:0044238;GO:0048699;GO:0007399;GO:0048856;GO:0044237;GO:0010558;GO:2000026;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;cell development;negative regulation of cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of cell projection organization;organic cyclic compound metabolic process;positive regulation of cell projection organization;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular developmental process;negative regulation of neuron differentiation;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of cell development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;negative regulation of neuron projection development;positive regulation of neuron projection development;regulation of neuron projection development;regulation of RNA biosynthetic process;heterocycle metabolic process;single-multicellular organism process;negative regulation of gene expression;aromatic compound biosynthetic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;neuron projection development;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;negative regulation of cell projection organization;cellular component organization;biological regulation;cellular component organization or biogenesis;heterocycle biosynthetic process;positive regulation of cellular component organization;regulation of neurogenesis;regulation of developmental process;regulation of biosynthetic process;tissue development;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of multicellular organismal process;RNA biosynthetic process;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;regulation of cell development;cellular macromolecule biosynthetic process;regulation of nervous system development;single-organism process;nucleobase-containing compound metabolic process;negative regulation of multicellular organismal process;negative regulation of neurogenesis;positive regulation of neurogenesis;negative regulation of cellular biosynthetic process;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;regulation of multicellular organismal process;negative regulation of developmental process;positive regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;system development;positive regulation of nucleic acid-templated transcription;positive regulation of cellular biosynthetic process;cell projection organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organism development;positive regulation of nervous system development;regulation of cellular macromolecule biosynthetic process;negative regulation of nervous system development;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;epithelial cell differentiation;neuron development;epithelium development;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;neuron differentiation;regulation of nucleobase-containing compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;neurogenesis;primary metabolic process;generation of neurons;nervous system development;anatomical structure development;cellular metabolic process;negative regulation of macromolecule biosynthetic process;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process; 4;3;4;6;5;5;4;5;4;4;4;6;7;6;5;5;2;2;4;7;6;6;6;6;4;3;5;5;3;3;4;4;3;5;7;4;4;5;3;2;2;5;4;6;3;4;4;3;1;2;5;5;6;5;6;5;5;6;3;6;5;4;4;4;4;5;5;5;2;4;3;5;5;5;2;2;2;4;7;7;4;4;4;6;6;3;3;3;5;5;5;4;6;5;7;4;7;5;4;5;4;4;4;5;4;4;6;4;2;3;5;7;5;6;5;5;5;5;6;5;3;3;5;3;4;4;4;6;3;7;5;3;3;5;4;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleus;cell part;cell;cellular_component; 4;3;3;3;3;2;5;2;2;1; GO:0043169;GO:0001071;GO:0003714;GO:0003712;GO:0046872;GO:0003674;GO:0005488;GO:0000989;GO:0000988;GO:0043167;GO:0003700; cation binding;nucleic acid binding transcription factor activity;transcription corepressor activity;transcription cofactor activity;metal ion binding;molecular_function;binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;ion binding;transcription factor activity, sequence-specific DNA binding; 4;2;5;4;5;1;2;3;2;3;3; K22751 IPR002893;IPR013291;IPR003894;IPR013289;IPR014896; Zinc finger, MYND-type;Myeloid transforming gene-related protein-1 (MTGR1);TAFH/NHR1;CBFA2T family;NHR2-like; nucleus Hs4826663 1251.0 K [K] Transcription; Q9NWZ5 Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2 - [UCKL1_HUMAN] 0.908 1.096 0.702 1.377 0.808 2.558 0.828467153 nan 1.704207921 nan 0.640510949 nan 3.165841584 nan GO:0009218;GO:0009165;GO:0044281;GO:0009161;GO:0046134;GO:1901362;GO:0046131;GO:1901360;GO:0044710;GO:0044711;GO:0044206;GO:0044419;GO:0009199;GO:0010138;GO:0009201;GO:0046036;GO:0009209;GO:0009208;GO:0009174;GO:0009173;GO:0042455;GO:0046483;GO:0044211;GO:1901564;GO:1901566;GO:0019438;GO:0009163;GO:0009148;GO:0009141;GO:0009142;GO:0009147;GO:0006807;GO:1901576;GO:0006206;GO:0046132;GO:0019637;GO:0018130;GO:0006221;GO:0009156;GO:0009260;GO:0008150;GO:0008152;GO:0034654;GO:0090407;GO:0043094;GO:0043097;GO:0044271;GO:0008655;GO:0043173;GO:0046390;GO:0006213;GO:1901293;GO:0044763;GO:0006753;GO:0044249;GO:0034641;GO:0009129;GO:0009123;GO:0009259;GO:0044699;GO:0006220;GO:0006139;GO:0006222;GO:0009987;GO:0006725;GO:0009130;GO:0055086;GO:1901137;GO:0032262;GO:1901135;GO:0043174;GO:0009124;GO:0072528;GO:0044237;GO:0046049;GO:0072527;GO:0071704;GO:0006241;GO:0051704;GO:0009220;GO:0009112;GO:0009058;GO:0044764;GO:0009117;GO:0009116;GO:0009119;GO:0044238;GO:0019693;GO:1901657;GO:0006796;GO:0016032;GO:0006793;GO:0044403;GO:1901659; pyrimidine ribonucleotide metabolic process;nucleotide biosynthetic process;small molecule metabolic process;ribonucleoside monophosphate metabolic process;pyrimidine nucleoside biosynthetic process;organic cyclic compound biosynthetic process;pyrimidine ribonucleoside metabolic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;UMP salvage;interspecies interaction between organisms;ribonucleoside triphosphate metabolic process;pyrimidine ribonucleotide salvage;ribonucleoside triphosphate biosynthetic process;CTP metabolic process;pyrimidine ribonucleoside triphosphate biosynthetic process;pyrimidine ribonucleoside triphosphate metabolic process;pyrimidine ribonucleoside monophosphate biosynthetic process;pyrimidine ribonucleoside monophosphate metabolic process;ribonucleoside biosynthetic process;heterocycle metabolic process;CTP salvage;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;aromatic compound biosynthetic process;nucleoside biosynthetic process;pyrimidine nucleoside triphosphate biosynthetic process;nucleoside triphosphate metabolic process;nucleoside triphosphate biosynthetic process;pyrimidine nucleoside triphosphate metabolic process;nitrogen compound metabolic process;organic substance biosynthetic process;pyrimidine nucleobase metabolic process;pyrimidine ribonucleoside biosynthetic process;organophosphate metabolic process;heterocycle biosynthetic process;pyrimidine nucleotide biosynthetic process;ribonucleoside monophosphate biosynthetic process;ribonucleotide biosynthetic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;organophosphate biosynthetic process;cellular metabolic compound salvage;pyrimidine nucleoside salvage;cellular nitrogen compound biosynthetic process;pyrimidine-containing compound salvage;nucleotide salvage;ribose phosphate biosynthetic process;pyrimidine nucleoside metabolic process;nucleoside phosphate biosynthetic process;single-organism cellular process;nucleoside phosphate metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;pyrimidine nucleoside monophosphate metabolic process;nucleoside monophosphate metabolic process;ribonucleotide metabolic process;single-organism process;pyrimidine nucleotide metabolic process;nucleobase-containing compound metabolic process;UMP biosynthetic process;cellular process;cellular aromatic compound metabolic process;pyrimidine nucleoside monophosphate biosynthetic process;nucleobase-containing small molecule metabolic process;carbohydrate derivative biosynthetic process;pyrimidine nucleotide salvage;carbohydrate derivative metabolic process;nucleoside salvage;nucleoside monophosphate biosynthetic process;pyrimidine-containing compound biosynthetic process;cellular metabolic process;UMP metabolic process;pyrimidine-containing compound metabolic process;organic substance metabolic process;CTP biosynthetic process;multi-organism process;pyrimidine ribonucleotide biosynthetic process;nucleobase metabolic process;biosynthetic process;multi-organism cellular process;nucleotide metabolic process;nucleoside metabolic process;ribonucleoside metabolic process;primary metabolic process;ribose phosphate metabolic process;glycosyl compound metabolic process;phosphate-containing compound metabolic process;viral process;phosphorus metabolic process;symbiosis, encompassing mutualism through parasitism;glycosyl compound biosynthetic process; 7;6;4;7;7;5;7;4;3;4;8;3;7;8;7;8;8;8;8;8;7;4;8;4;5;5;6;7;6;6;7;3;4;6;8;4;5;7;7;7;1;2;5;5;5;7;5;6;6;6;6;5;3;5;4;4;7;6;6;2;6;4;9;2;4;7;4;5;7;4;6;6;6;3;8;5;3;9;2;8;5;3;3;6;5;6;3;5;4;5;4;4;4;5; GO:0043231;GO:0005829;GO:0044424;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044444;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575; intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;cytoplasmic part;nucleus;cell part;cell;intracellular;cellular_component; 4;5;3;3;3;2;4;4;5;2;2;3;1; GO:0000166;GO:0017076;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0005524;GO:0016301;GO:0004849;GO:0003824;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0016740;GO:0043167;GO:0030554;GO:0016772;GO:0097159;GO:0019206;GO:0019205;GO:0001883;GO:0001882;GO:0036094;GO:0043168; nucleotide binding;purine nucleotide binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;ATP binding;kinase activity;uridine kinase activity;catalytic activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;transferase activity;ion binding;adenyl nucleotide binding;transferase activity, transferring phosphorus-containing groups;organic cyclic compound binding;nucleoside kinase activity;nucleobase-containing compound kinase activity;purine nucleoside binding;nucleoside binding;small molecule binding;anion binding; 4;5;3;1;2;4;3;5;6;5;8;2;6;5;6;4;5;3;3;6;4;3;7;6;5;4;3;4; K00876 map00240;map00983;map01100; Pyrimidine metabolism;Drug metabolism - other enzymes;Metabolic pathways; IPR000836;IPR006083;IPR029933;IPR000764;IPR029057;IPR027417; Phosphoribosyltransferase domain;Phosphoribulokinase/uridine kinase;Uridine-cytidine kinase-like 1;Uridine kinase-like;Phosphoribosyltransferase-like;P-loop containing nucleoside triphosphate hydrolase; cytosol Hs8923487 1133.0 TZ [T] Signal transduction mechanisms;[Z] Cytoskeleton; Q14258 E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2 - [TRI25_HUMAN] 0.811 1.119 0.739 1.242 1.212 1.664 0.724754245 nan 1.024752475 nan 0.660411081 nan 1.372937294 nan GO:0019221;GO:0019222;GO:0043412;GO:0048583;GO:0007165;GO:0007166;GO:0010556;GO:1901362;GO:1901360;GO:0032774;GO:0044712;GO:0051716;GO:0044711;GO:0010604;GO:0009966;GO:0009967;GO:0070647;GO:0010467;GO:0044419;GO:0032446;GO:0019058;GO:0044093;GO:0048518;GO:0048519;GO:0043122;GO:0043123;GO:1902680;GO:0048584;GO:0006281;GO:0060255;GO:0030163;GO:2001141;GO:0051701;GO:0051707;GO:0010033;GO:0051704;GO:0044700;GO:0009607;GO:0044707;GO:0019538;GO:0019985;GO:0002376;GO:0016567;GO:0006259;GO:0033554;GO:0019438;GO:0046718;GO:0009893;GO:0032480;GO:0009891;GO:0007249;GO:0010647;GO:0023051;GO:0036503;GO:0006807;GO:0035556;GO:0043170;GO:0050789;GO:0097659;GO:0009605;GO:0044267;GO:1901575;GO:0044265;GO:0071897;GO:0046483;GO:0009719;GO:0065007;GO:0014070;GO:0065009;GO:0018130;GO:0034097;GO:0006139;GO:0050792;GO:0009889;GO:0044710;GO:0050794;GO:0006952;GO:0043900;GO:0043901;GO:0008150;GO:0008152;GO:0006955;GO:0034654;GO:1902533;GO:1902531;GO:0051092;GO:0060333;GO:0051603;GO:0044271;GO:0051607;GO:0043903;GO:0071345;GO:0050896;GO:0071346;GO:0006950;GO:0006355;GO:0010557;GO:0036211;GO:0048545;GO:0009615;GO:0043207;GO:0051239;GO:0044248;GO:0030260;GO:0034641;GO:0023052;GO:0070887;GO:0007154;GO:0052126;GO:0010646;GO:0044699;GO:1903900;GO:1903901;GO:0009056;GO:0051241;GO:0031326;GO:0006508;GO:1903508;GO:0016070;GO:0032501;GO:0019076;GO:0009987;GO:0019941;GO:1903506;GO:0006974;GO:0034645;GO:0098542;GO:0045893;GO:0044257;GO:0090304;GO:0051091;GO:0051090;GO:0009725;GO:0051252;GO:0051254;GO:0001816;GO:0001817;GO:0051828;GO:0010628;GO:0032479;GO:0001818;GO:0034976;GO:0031328;GO:1902187;GO:1902186;GO:0031325;GO:0031323;GO:0032606;GO:0046596;GO:0046597;GO:0043632;GO:0006513;GO:0033993;GO:0000731;GO:2000112;GO:0071704;GO:0071310;GO:0006511;GO:0042787;GO:0006301;GO:0009059;GO:0010468;GO:0006351;GO:0045935;GO:1901576;GO:0019219;GO:0006725;GO:0045087;GO:0080090;GO:0006464;GO:0034341;GO:0009058;GO:0044764;GO:0044763;GO:0051171;GO:0051173;GO:0043627;GO:0042221;GO:0009057;GO:0023056;GO:0040011;GO:0044238;GO:0040013;GO:0040012;GO:0044260;GO:0052192;GO:0044237;GO:0044409;GO:0016032;GO:0002252;GO:0048525;GO:0044403;GO:0051806;GO:0044249;GO:0048523;GO:0048522; cytokine-mediated signaling pathway;regulation of metabolic process;macromolecule modification;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;regulation of macromolecule biosynthetic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;RNA biosynthetic process;single-organism catabolic process;cellular response to stimulus;single-organism biosynthetic process;positive regulation of macromolecule metabolic process;regulation of signal transduction;positive regulation of signal transduction;protein modification by small protein conjugation or removal;gene expression;interspecies interaction between organisms;protein modification by small protein conjugation;viral life cycle;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of RNA biosynthetic process;positive regulation of response to stimulus;DNA repair;regulation of macromolecule metabolic process;protein catabolic process;regulation of RNA biosynthetic process;interaction with host;response to other organism;response to organic substance;multi-organism process;single organism signaling;response to biotic stimulus;single-multicellular organism process;protein metabolic process;translesion synthesis;immune system process;protein ubiquitination;DNA metabolic process;cellular response to stress;aromatic compound biosynthetic process;viral entry into host cell;positive regulation of metabolic process;negative regulation of type I interferon production;positive regulation of biosynthetic process;I-kappaB kinase/NF-kappaB signaling;positive regulation of cell communication;regulation of signaling;ERAD pathway;nitrogen compound metabolic process;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;response to external stimulus;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;DNA biosynthetic process;heterocycle metabolic process;response to endogenous stimulus;biological regulation;response to organic cyclic compound;regulation of molecular function;heterocycle biosynthetic process;response to cytokine;nucleobase-containing compound metabolic process;regulation of viral process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;defense response;regulation of multi-organism process;negative regulation of multi-organism process;biological_process;metabolic process;immune response;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;positive regulation of NF-kappaB transcription factor activity;interferon-gamma-mediated signaling pathway;proteolysis involved in cellular protein catabolic process;cellular nitrogen compound biosynthetic process;defense response to virus;regulation of symbiosis, encompassing mutualism through parasitism;cellular response to cytokine stimulus;response to stimulus;cellular response to interferon-gamma;response to stress;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;protein modification process;response to steroid hormone;response to virus;response to external biotic stimulus;regulation of multicellular organismal process;cellular catabolic process;entry into host cell;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;cell communication;movement in host environment;regulation of cell communication;single-organism process;regulation of viral life cycle;negative regulation of viral life cycle;catabolic process;negative regulation of multicellular organismal process;regulation of cellular biosynthetic process;proteolysis;positive regulation of nucleic acid-templated transcription;RNA metabolic process;multicellular organismal process;viral release from host cell;cellular process;modification-dependent protein catabolic process;regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;cellular macromolecule biosynthetic process;defense response to other organism;positive regulation of transcription, DNA-templated;cellular protein catabolic process;nucleic acid metabolic process;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of sequence-specific DNA binding transcription factor activity;response to hormone;regulation of RNA metabolic process;positive regulation of RNA metabolic process;cytokine production;regulation of cytokine production;entry into other organism involved in symbiotic interaction;positive regulation of gene expression;regulation of type I interferon production;negative regulation of cytokine production;response to endoplasmic reticulum stress;positive regulation of cellular biosynthetic process;negative regulation of viral release from host cell;regulation of viral release from host cell;positive regulation of cellular metabolic process;regulation of cellular metabolic process;type I interferon production;regulation of viral entry into host cell;negative regulation of viral entry into host cell;modification-dependent macromolecule catabolic process;protein monoubiquitination;response to lipid;DNA synthesis involved in DNA repair;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;ubiquitin-dependent protein catabolic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;postreplication repair;macromolecule biosynthetic process;regulation of gene expression;transcription, DNA-templated;positive regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;innate immune response;regulation of primary metabolic process;cellular protein modification process;response to interferon-gamma;biosynthetic process;multi-organism cellular process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to estrogen;response to chemical;macromolecule catabolic process;positive regulation of signaling;locomotion;primary metabolic process;negative regulation of locomotion;regulation of locomotion;cellular macromolecule metabolic process;movement in environment of other organism involved in symbiotic interaction;cellular metabolic process;entry into host;viral process;immune effector process;negative regulation of viral process;symbiosis, encompassing mutualism through parasitism;entry into cell of other organism involved in symbiotic interaction;cellular biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 6;3;5;3;4;5;5;5;4;6;4;3;4;4;4;4;7;5;3;8;5;4;2;2;6;6;6;3;4;4;5;6;4;3;4;2;3;3;3;4;5;2;9;5;4;5;6;3;5;4;6;4;3;4;3;5;4;2;7;3;5;4;5;6;4;3;2;5;3;5;5;4;4;4;3;3;4;3;3;1;2;3;5;5;5;6;7;6;5;4;4;6;2;6;3;6;5;5;5;4;4;3;4;6;4;2;4;4;4;4;2;5;5;3;3;5;5;7;5;2;5;2;7;7;5;5;4;6;6;5;5;4;4;5;5;4;4;4;5;5;4;5;5;6;6;4;4;5;4;4;6;10;5;5;6;3;5;8;9;5;5;5;6;5;4;5;4;4;4;6;5;3;3;3;4;4;6;3;5;3;2;3;3;3;4;3;3;5;4;3;4;4;5;4;3;3; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0005654;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0044444;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;nucleoplasm;intracellular organelle part;cytoplasm;nucleus;cell part;cell;intracellular;cytoplasmic part;organelle;cellular_component;intracellular organelle lumen; 2;5;4;3;5;4;3;2;3;3;5;3;4;5;2;2;3;4;2;1;4; GO:1901363;GO:0016740;GO:0046872;GO:0008270;GO:0016881;GO:0003674;GO:0005488;GO:0003676;GO:0046914;GO:0019787;GO:0003824;GO:0004842;GO:0097159;GO:1904264;GO:0061659;GO:0043169;GO:0043167;GO:0001071;GO:0044822;GO:0003723;GO:0061630;GO:0016879;GO:0016874;GO:0003700; heterocyclic compound binding;transferase activity;metal ion binding;zinc ion binding;acid-amino acid ligase activity;molecular_function;binding;nucleic acid binding;transition metal ion binding;ubiquitin-like protein transferase activity;catalytic activity;ubiquitin-protein transferase activity;organic cyclic compound binding;ubiquitin protein ligase activity involved in ERAD pathway;ubiquitin-like protein ligase activity;cation binding;ion binding;nucleic acid binding transcription factor activity;poly(A) RNA binding;RNA binding;ubiquitin protein ligase activity;ligase activity, forming carbon-nitrogen bonds;ligase activity;transcription factor activity, sequence-specific DNA binding; 3;3;5;7;5;1;2;4;6;4;2;5;3;7;5;4;3;2;6;5;6;4;3;3; K10652 map04064;map04622;map05164; NF-kappa B signaling pathway;RIG-I-like receptor signaling pathway;Influenza A; IPR003879;IPR006574;IPR017907;IPR013083;IPR027370;IPR013320;IPR001870;IPR003877;IPR001841; Butyrophylin-like, SPRY domain;SPRY-associated;Zinc finger, RING-type, conserved site;Zinc finger, RING/FYVE/PHD-type;RING-type zinc-finger, LisH dimerisation motif;Concanavalin A-like lectin/glucanase domain;B30.2/SPRY domain;SPRY domain;Zinc finger, RING-type; nucleus Hs4827065 1308.0 O [O] Posttranslational modification, protein turnover, chaperones; Q08AM6 Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1 - [VAC14_HUMAN] 0.813 0.672 2.016 0.781 0.653 1.144 1.209821429 0.067876641 1.196018377 0.202512879 3 0.001289448 1.751914242 0.121702361 GO:0019220;GO:0080090;GO:0019222;GO:0007165;GO:0044710;GO:0044711;GO:0044419;GO:0046488;GO:0046486;GO:0051704;GO:0044700;GO:0044281;GO:0050789;GO:1901576;GO:0043549;GO:0065007;GO:0065009;GO:0006629;GO:0042325;GO:0050790;GO:0051716;GO:0050794;GO:0019637;GO:0008150;GO:0008152;GO:0090407;GO:0043550;GO:0008654;GO:0050896;GO:0051338;GO:0016310;GO:0044249;GO:0023052;GO:0044699;GO:0006644;GO:0009987;GO:0006661;GO:0044255;GO:0046474;GO:0006650;GO:0031323;GO:0045017;GO:0071704;GO:0019216;GO:0051174;GO:0009058;GO:0044764;GO:0044763;GO:0007154;GO:0008610;GO:0044238;GO:0044237;GO:0006796;GO:0016032;GO:0006793;GO:0044403; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;signal transduction;single-organism metabolic process;single-organism biosynthetic process;interspecies interaction between organisms;phosphatidylinositol metabolic process;glycerolipid metabolic process;multi-organism process;single organism signaling;small molecule metabolic process;regulation of biological process;organic substance biosynthetic process;regulation of kinase activity;biological regulation;regulation of molecular function;lipid metabolic process;regulation of phosphorylation;regulation of catalytic activity;cellular response to stimulus;regulation of cellular process;organophosphate metabolic process;biological_process;metabolic process;organophosphate biosynthetic process;regulation of lipid kinase activity;phospholipid biosynthetic process;response to stimulus;regulation of transferase activity;phosphorylation;cellular biosynthetic process;signaling;single-organism process;phospholipid metabolic process;cellular process;phosphatidylinositol biosynthetic process;cellular lipid metabolic process;glycerophospholipid biosynthetic process;glycerophospholipid metabolic process;regulation of cellular metabolic process;glycerolipid biosynthetic process;organic substance metabolic process;regulation of lipid metabolic process;regulation of phosphorus metabolic process;biosynthetic process;multi-organism cellular process;single-organism cellular process;cell communication;lipid biosynthetic process;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;viral process;phosphorus metabolic process;symbiosis, encompassing mutualism through parasitism; 6;4;3;4;3;4;3;7;5;2;3;4;2;4;6;2;3;4;7;4;3;3;4;1;2;5;6;5;2;5;6;4;2;2;5;2;7;4;6;6;4;5;3;5;5;3;3;3;4;5;3;3;5;4;4;4; GO:0005783;GO:0005942;GO:0005773;GO:0016020;GO:0005774;GO:0044437;GO:0031902;GO:0031901;GO:0005794;GO:1902494;GO:0098588;GO:1990234;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0044440;GO:0005770;GO:0019898;GO:0010008;GO:0005737;GO:0031090;GO:0061695;GO:0035032;GO:0070772;GO:0044464;GO:0005623;GO:0005622;GO:0098805;GO:0043226;GO:0032991;GO:0005575;GO:0098796;GO:0005768;GO:0005769; endoplasmic reticulum;phosphatidylinositol 3-kinase complex;vacuole;membrane;vacuolar membrane;vacuolar part;late endosome membrane;early endosome membrane;Golgi apparatus;catalytic complex;bounding membrane of organelle;transferase complex;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;endosomal part;late endosome;extrinsic component of membrane;endosome membrane;cytoplasm;organelle membrane;transferase complex, transferring phosphorus-containing groups;phosphatidylinositol 3-kinase complex, class III;PAS complex;cell part;cell;intracellular;whole membrane;organelle;macromolecular complex;cellular_component;membrane protein complex;endosome;early endosome; 4;4;5;2;4;4;6;6;4;4;4;5;3;4;3;2;2;3;3;4;3;5;3;4;5;5;3;5;4;3;6;5;5;2;2;3;3;2;2;1;3;4;5; GO:0060089;GO:0003674;GO:0004872; molecular transducer activity;molecular_function;receptor activity; 2;1;3; K15305 map05166;map05203; HTLV-I infection;Viral carcinogenesis; IPR026825;IPR021841;IPR016024;IPR011989;IPR032878; Vacuole morphology and inheritance protein 14;Vacuolar protein 14 C-terminal Fig4-binding domain;Armadillo-type fold;Armadillo-like helical;Vacuole morphology and inheritance protein 14, Fab1-binding region; cytosol Hs20070299 1082.0 S [S] Function unknown; A8MYU2 Potassium channel subfamily U member 1 OS=Homo sapiens OX=9606 GN=KCNU1 PE=1 SV=2 - [KCNU1_HUMAN] 1.028 1.422 0.358 1.245 1.285 1.166 0.722925457 nan 0.968871595 nan 0.251758087 nan 0.907392996 nan GO:0009566;GO:0019953;GO:0009988;GO:0000003;GO:0044699;GO:0008037;GO:0032501;GO:0032504;GO:0035036;GO:0022414;GO:0044702;GO:0008150;GO:0007338;GO:0044763;GO:0051704;GO:0044703;GO:0009987; fertilization;sexual reproduction;cell-cell recognition;reproduction;single-organism process;cell recognition;multicellular organismal process;multicellular organism reproduction;sperm-egg recognition;reproductive process;single organism reproductive process;biological_process;single fertilization;single-organism cellular process;multi-organism process;multi-organism reproductive process;cellular process; 4;3;5;2;2;4;2;3;4;2;3;1;5;3;2;3;2; GO:0071944;GO:0034703;GO:0031226;GO:0031224;GO:0005575;GO:0016021;GO:0016020;GO:0044425;GO:0044459;GO:0043234;GO:1902495;GO:1990351;GO:0008076;GO:0005887;GO:0005886;GO:0032991;GO:0098797;GO:0044464;GO:0005623;GO:0098796;GO:0034705;GO:0034702; cell periphery;cation channel complex;intrinsic component of plasma membrane;intrinsic component of membrane;cellular_component;integral component of membrane;membrane;membrane part;plasma membrane part;protein complex;transmembrane transporter complex;transporter complex;voltage-gated potassium channel complex;integral component of plasma membrane;plasma membrane;macromolecular complex;plasma membrane protein complex;cell part;cell;membrane protein complex;potassium channel complex;ion channel complex; 3;6;4;3;1;4;2;2;3;3;4;4;5;4;3;2;4;2;2;3;7;5; GO:0005267;GO:0005261;GO:0060072;GO:0005227;GO:0003674;GO:0022832;GO:0015077;GO:0022803;GO:0046873;GO:0022836;GO:0005215;GO:0005216;GO:0008324;GO:0022843;GO:0022839;GO:0022891;GO:0022890;GO:0022892;GO:0005244;GO:0015075;GO:0022857;GO:0015267;GO:0005249;GO:0022838;GO:0015079;GO:0015269; potassium channel activity;cation channel activity;large conductance calcium-activated potassium channel activity;calcium activated cation channel activity;molecular_function;voltage-gated channel activity;monovalent inorganic cation transmembrane transporter activity;passive transmembrane transporter activity;metal ion transmembrane transporter activity;gated channel activity;transporter activity;ion channel activity;cation transmembrane transporter activity;voltage-gated cation channel activity;ion gated channel activity;substrate-specific transmembrane transporter activity;inorganic cation transmembrane transporter activity;substrate-specific transporter activity;voltage-gated ion channel activity;ion transmembrane transporter activity;transmembrane transporter activity;channel activity;voltage-gated potassium channel activity;substrate-specific channel activity;potassium ion transmembrane transporter activity;calcium-activated potassium channel activity; 8;7;10;8;1;7;8;4;8;6;2;6;6;8;7;4;7;3;7;5;3;5;9;5;9;9; K05274 map04022;map04270;map04911; cGMP-PKG signaling pathway;Vascular smooth muscle contraction;Insulin secretion; IPR005821;IPR003929; Ion transport domain;Potassium channel, BK, alpha subunit; plasma membrane Hs4504853 907.0 PT [P] Inorganic ion transport and metabolism;[T] Signal transduction mechanisms; Q99798 Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2 - [ACON_HUMAN] 0.945 0.674 1.857 0.665 0.784 1.056 1.402077151 nan 0.848214286 nan 2.755192878 nan 1.346938776 nan GO:0044237;GO:0019752;GO:0009060;GO:0006091;GO:0072350;GO:0044699;GO:0044710;GO:0071704;GO:0009987;GO:0045333;GO:0008152;GO:0043436;GO:0055114;GO:0044238;GO:0006082;GO:0006099;GO:0044763;GO:0015980;GO:0006101;GO:0006102;GO:0008150;GO:0044281; cellular metabolic process;carboxylic acid metabolic process;aerobic respiration;generation of precursor metabolites and energy;tricarboxylic acid metabolic process;single-organism process;single-organism metabolic process;organic substance metabolic process;cellular process;cellular respiration;metabolic process;oxoacid metabolic process;oxidation-reduction process;primary metabolic process;organic acid metabolic process;tricarboxylic acid cycle;single-organism cellular process;energy derivation by oxidation of organic compounds;citrate metabolic process;isocitrate metabolic process;biological_process;small molecule metabolic process; 3;6;6;4;7;2;3;3;2;5;2;5;4;3;4;4;3;4;8;8;1;4; GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070013;GO:0043209;GO:0005634;GO:0005739;GO:0005759;GO:0031974;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044429;GO:0044424;GO:0044422; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;intracellular organelle lumen;myelin sheath;nucleus;mitochondrion;mitochondrial matrix;membrane-enclosed lumen;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;cellular_component;cytoplasmic part;mitochondrial part;intracellular part;organelle part; 3;3;2;4;3;4;3;5;5;5;2;4;3;2;2;3;1;4;4;3;2; GO:0003674;GO:0005488;GO:0051540;GO:0046914;GO:0043167;GO:0005506;GO:0046872;GO:0043169;GO:0003824;GO:0003994;GO:0051538;GO:0051539;GO:0016835;GO:0051536;GO:0016829;GO:0016836; molecular_function;binding;metal cluster binding;transition metal ion binding;ion binding;iron ion binding;metal ion binding;cation binding;catalytic activity;aconitate hydratase activity;3 iron, 4 sulfur cluster binding;4 iron, 4 sulfur cluster binding;carbon-oxygen lyase activity;iron-sulfur cluster binding;lyase activity;hydro-lyase activity; 1;2;3;6;3;7;5;4;2;6;5;5;4;4;3;5; K01681 map00020;map00630;map00720;map01100;map01110;map01120;map01130;map01200;map01210;map01230; Citrate cycle (TCA cycle);Glyoxylate and dicarboxylate metabolism;Carbon fixation pathways in prokaryotes;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism;2-Oxocarboxylic acid metabolism;Biosynthesis of amino acids; IPR001030;IPR006248;IPR015931;IPR015932;IPR018136;IPR000573;IPR015928; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain;Aconitase, mitochondrial-like;Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3;Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2;Aconitase family, 4Fe-4S cluster binding site;Aconitase A/isopropylmalate dehydratase small subunit, swivel domain;Aconitase/3-isopropylmalate dehydratase, swivel; mitochondria Hs4501867 1616.0 CE [C] Energy production and conversion;[E] Amino acid transport and metabolism; A0A0C4DH68 Immunoglobulin kappa variable 2-24 OS=Homo sapiens OX=9606 GN=IGKV2-24 PE=3 SV=1 - [KV224_HUMAN] 1.018 1.096 0.815 1.066 1.174 0.888 0.928832117 0.323985805 0.908006814 0.115538869 0.743613139 0.004071858 0.756388416 0.36335483 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1 - [PK3CB_HUMAN] 0.806 0.69 1.793 0.714 1.092 0.581 1.168115942 nan 0.653846154 nan 2.598550725 nan 0.532051282 nan GO:0048010;GO:0019220;GO:0080090;GO:0019222;GO:0051049;GO:0048584;GO:0048583;GO:0032147;GO:0007160;GO:0055080;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0060326;GO:0007599;GO:0055082;GO:0023014;GO:0051716;GO:0044711;GO:0090407;GO:0010604;GO:0042330;GO:0009966;GO:0009967;GO:0071840;GO:0000165;GO:0009611;GO:0048514;GO:0030168;GO:0044093;GO:0048518;GO:0002682;GO:0050673;GO:0030155;GO:0019725;GO:0031589;GO:0007596;GO:0038179;GO:0006935;GO:0060255;GO:0045859;GO:0048731;GO:0042221;GO:0050776;GO:0046488;GO:0070527;GO:0046486;GO:0010033;GO:0098742;GO:0042325;GO:0044700;GO:0042327;GO:0016477;GO:0016192;GO:0044707;GO:0048870;GO:0019538;GO:0010243;GO:0048856;GO:0048878;GO:0002376;GO:0048646;GO:0050778;GO:0019637;GO:0055074;GO:0009896;GO:0009894;GO:0009893;GO:0033674;GO:0006909;GO:0007167;GO:0006928;GO:0098771;GO:0051674;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0009605;GO:0044267;GO:0009653;GO:0051347;GO:0002764;GO:0044260;GO:0002431;GO:0002768;GO:0001568;GO:0043549;GO:0044344;GO:0016043;GO:0002684;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0007186;GO:0045087;GO:0006810;GO:0006629;GO:0098609;GO:0050790;GO:0044710;GO:0042060;GO:0050794;GO:0043410;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:0048011;GO:1902533;GO:0048259;GO:1902531;GO:0048015;GO:0048017;GO:0071375;GO:0038096;GO:0006952;GO:0038094;GO:0002757;GO:0006897;GO:0008654;GO:0050896;GO:0006898;GO:0006950;GO:0051338;GO:0050817;GO:0071774;GO:2000369;GO:0006954;GO:0016310;GO:0050801;GO:0071310;GO:0072583;GO:0051128;GO:0023056;GO:0043406;GO:0043405;GO:0023052;GO:0038127;GO:0070887;GO:0023051;GO:0016337;GO:0010647;GO:0010646;GO:0008543;GO:0070848;GO:0044699;GO:0043408;GO:0009719;GO:0072507;GO:0051234;GO:0072503;GO:0009056;GO:0010562;GO:0051246;GO:0051247;GO:0010508;GO:0050852;GO:0002429;GO:0032270;GO:1902578;GO:0031399;GO:0022610;GO:0071495;GO:1901700;GO:0006644;GO:0032501;GO:0044281;GO:0050878;GO:0006875;GO:0031331;GO:0009987;GO:0006873;GO:0060627;GO:0032870;GO:0038095;GO:1901701;GO:0030003;GO:0006661;GO:0014065;GO:0044255;GO:0032879;GO:0038093;GO:0044765;GO:0001775;GO:0032268;GO:0071363;GO:0043434;GO:0009725;GO:0040016;GO:0007169;GO:0043170;GO:1901699;GO:0002433;GO:0010628;GO:0046474;GO:0045860;GO:0009790;GO:1901698;GO:0000187;GO:0032502;GO:0031401;GO:0044767;GO:0006650;GO:0031329;GO:0001944;GO:0031325;GO:0031323;GO:0008286;GO:0042592;GO:0050900;GO:0051301;GO:0032868;GO:0032869;GO:0001525;GO:0007275;GO:0045017;GO:0071417;GO:0008283;GO:0071704;GO:0010467;GO:0006874;GO:0010506;GO:0010468;GO:0002250;GO:0050851;GO:0006468;GO:0045937;GO:1901576;GO:0010810;GO:0034109;GO:0006914;GO:0002252;GO:0006464;GO:0051174;GO:0009058;GO:0044763;GO:0060055;GO:0055065;GO:0007155;GO:0007154;GO:0007156;GO:0030100;GO:0051179;GO:0044248;GO:0008610;GO:0040011;GO:0044238;GO:0098602;GO:0001935;GO:0044237;GO:0006796;GO:1901652;GO:1901653;GO:0002253;GO:0006793;GO:0007173;GO:0001932;GO:0044249;GO:0001934;GO:0001952;GO:0048522; vascular endothelial growth factor receptor signaling pathway;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;cell-matrix adhesion;cation homeostasis;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;cell chemotaxis;hemostasis;cellular chemical homeostasis;signal transduction by protein phosphorylation;cellular response to stimulus;single-organism biosynthetic process;organophosphate biosynthetic process;positive regulation of macromolecule metabolic process;taxis;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;response to wounding;blood vessel morphogenesis;platelet activation;positive regulation of molecular function;positive regulation of biological process;regulation of immune system process;epithelial cell proliferation;regulation of cell adhesion;cellular homeostasis;cell-substrate adhesion;blood coagulation;neurotrophin signaling pathway;chemotaxis;regulation of macromolecule metabolic process;regulation of protein kinase activity;system development;response to chemical;regulation of immune response;phosphatidylinositol metabolic process;platelet aggregation;glycerolipid metabolic process;response to organic substance;cell-cell adhesion via plasma-membrane adhesion molecules;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;cell migration;vesicle-mediated transport;single-multicellular organism process;cell motility;protein metabolic process;response to organonitrogen compound;anatomical structure development;chemical homeostasis;immune system process;anatomical structure formation involved in morphogenesis;positive regulation of immune response;organophosphate metabolic process;calcium ion homeostasis;positive regulation of catabolic process;regulation of catabolic process;positive regulation of metabolic process;positive regulation of kinase activity;phagocytosis;enzyme linked receptor protein signaling pathway;movement of cell or subcellular component;inorganic ion homeostasis;localization of cell;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;response to external stimulus;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;immune response-regulating signaling pathway;cellular macromolecule metabolic process;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;blood vessel development;regulation of kinase activity;cellular response to fibroblast growth factor stimulus;cellular component organization;positive regulation of immune system process;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;G-protein coupled receptor signaling pathway;innate immune response;transport;lipid metabolic process;cell-cell adhesion;regulation of catalytic activity;single-organism metabolic process;wound healing;regulation of cellular process;positive regulation of MAPK cascade;macromolecule modification;protein modification process;biological_process;metabolic process;immune response;neurotrophin TRK receptor signaling pathway;positive regulation of intracellular signal transduction;regulation of receptor-mediated endocytosis;regulation of intracellular signal transduction;phosphatidylinositol-mediated signaling;inositol lipid-mediated signaling;cellular response to peptide hormone stimulus;Fc-gamma receptor signaling pathway involved in phagocytosis;defense response;Fc-gamma receptor signaling pathway;immune response-activating signal transduction;endocytosis;phospholipid biosynthetic process;response to stimulus;receptor-mediated endocytosis;response to stress;regulation of transferase activity;coagulation;response to fibroblast growth factor;regulation of clathrin-mediated endocytosis;inflammatory response;phosphorylation;ion homeostasis;cellular response to organic substance;clathrin-mediated endocytosis;regulation of cellular component organization;positive regulation of signaling;positive regulation of MAP kinase activity;regulation of MAP kinase activity;signaling;ERBB signaling pathway;cellular response to chemical stimulus;regulation of signaling;single organismal cell-cell adhesion;positive regulation of cell communication;regulation of cell communication;fibroblast growth factor receptor signaling pathway;response to growth factor;single-organism process;regulation of MAPK cascade;response to endogenous stimulus;divalent inorganic cation homeostasis;establishment of localization;cellular divalent inorganic cation homeostasis;catabolic process;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of autophagy;T cell receptor signaling pathway;immune response-activating cell surface receptor signaling pathway;positive regulation of cellular protein metabolic process;single-organism localization;regulation of protein modification process;biological adhesion;cellular response to endogenous stimulus;response to oxygen-containing compound;phospholipid metabolic process;multicellular organismal process;small molecule metabolic process;regulation of body fluid levels;cellular metal ion homeostasis;positive regulation of cellular catabolic process;cellular process;cellular ion homeostasis;regulation of vesicle-mediated transport;cellular response to hormone stimulus;Fc-epsilon receptor signaling pathway;cellular response to oxygen-containing compound;cellular cation homeostasis;phosphatidylinositol biosynthetic process;phosphatidylinositol 3-kinase signaling;cellular lipid metabolic process;regulation of localization;Fc receptor signaling pathway;single-organism transport;cell activation;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;response to peptide hormone;response to hormone;embryonic cleavage;transmembrane receptor protein tyrosine kinase signaling pathway;macromolecule metabolic process;cellular response to nitrogen compound;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;positive regulation of gene expression;glycerophospholipid biosynthetic process;positive regulation of protein kinase activity;embryo development;response to nitrogen compound;activation of MAPK activity;developmental process;positive regulation of protein modification process;single-organism developmental process;glycerophospholipid metabolic process;regulation of cellular catabolic process;vasculature development;positive regulation of cellular metabolic process;regulation of cellular metabolic process;insulin receptor signaling pathway;homeostatic process;leukocyte migration;cell division;response to insulin;cellular response to insulin stimulus;angiogenesis;multicellular organism development;glycerolipid biosynthetic process;cellular response to organonitrogen compound;cell proliferation;organic substance metabolic process;gene expression;cellular calcium ion homeostasis;regulation of autophagy;regulation of gene expression;adaptive immune response;antigen receptor-mediated signaling pathway;protein phosphorylation;positive regulation of phosphate metabolic process;organic substance biosynthetic process;regulation of cell-substrate adhesion;homotypic cell-cell adhesion;autophagy;immune effector process;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;single-organism cellular process;angiogenesis involved in wound healing;metal ion homeostasis;cell adhesion;cell communication;homophilic cell adhesion via plasma membrane adhesion molecules;regulation of endocytosis;localization;cellular catabolic process;lipid biosynthetic process;locomotion;primary metabolic process;single organism cell adhesion;endothelial cell proliferation;cellular metabolic process;phosphate-containing compound metabolic process;response to peptide;cellular response to peptide;activation of immune response;phosphorus metabolic process;epidermal growth factor receptor signaling pathway;regulation of protein phosphorylation;cellular biosynthetic process;positive regulation of protein phosphorylation;regulation of cell-matrix adhesion;positive regulation of cellular process; 8;6;4;3;4;3;3;9;5;7;5;5;4;5;5;5;5;4;3;4;5;4;3;4;4;2;5;4;4;5;4;2;3;4;4;4;4;5;6;4;4;7;4;3;4;7;6;5;4;5;7;3;7;4;5;3;3;4;4;3;5;2;3;4;4;9;4;4;3;7;5;6;4;7;3;9;5;8;2;3;5;3;6;5;4;6;6;4;6;5;3;3;2;5;3;3;5;4;4;4;4;4;3;5;3;6;5;5;1;2;3;7;5;6;5;7;6;6;5;4;8;4;6;5;2;7;3;5;4;4;7;5;6;6;5;8;4;3;7;7;2;8;4;3;4;4;4;6;5;2;6;3;8;3;8;3;5;5;5;4;7;5;5;3;6;2;4;4;5;2;4;4;8;5;2;6;4;5;8;5;7;7;8;4;3;7;4;4;5;6;5;4;5;7;4;5;4;5;6;8;5;4;8;2;6;3;6;5;5;4;4;8;4;3;4;6;7;4;4;5;5;3;3;5;9;4;5;4;6;7;6;4;5;5;3;3;6;5;3;3;5;8;3;4;6;5;2;4;5;2;3;3;5;3;5;5;6;3;4;9;7;4;7;6;3; GO:0031974;GO:0043228;GO:0016020;GO:0043234;GO:1990234;GO:0019898;GO:0043231;GO:0043233;GO:0044428;GO:0044425;GO:0044421;GO:0044422;GO:0043232;GO:0043229;GO:0043227;GO:0005886;GO:0005942;GO:0044446;GO:0044444;GO:0005634;GO:0045171;GO:0005730;GO:0005829;GO:0061695;GO:0044464;GO:0005623;GO:0005737;GO:0071944;GO:0044424;GO:1902494;GO:0070013;GO:0043226;GO:0005622;GO:0032991;GO:0031981;GO:0005575;GO:0098796;GO:0005576; membrane-enclosed lumen;non-membrane-bounded organelle;membrane;protein complex;transferase complex;extrinsic component of membrane;intracellular membrane-bounded organelle;organelle lumen;nuclear part;membrane part;extracellular region part;organelle part;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;plasma membrane;phosphatidylinositol 3-kinase complex;intracellular organelle part;cytoplasmic part;nucleus;intercellular bridge;nucleolus;cytosol;transferase complex, transferring phosphorus-containing groups;cell part;cell;cytoplasm;cell periphery;intracellular part;catalytic complex;intracellular organelle lumen;organelle;intracellular;macromolecular complex;nuclear lumen;cellular_component;membrane protein complex;extracellular region; 2;3;2;3;5;3;4;3;4;2;2;2;4;3;3;3;4;3;4;5;3;5;5;6;2;2;4;3;3;4;4;2;3;2;5;1;3;2; GO:0016307;GO:0000166;GO:0016740;GO:0097367;GO:0003674;GO:0005488;GO:0035004;GO:0035005;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005524;GO:0046934;GO:0016303;GO:0003824;GO:0016773;GO:0016772;GO:0032559;GO:0032553;GO:0035639;GO:0052813;GO:0030554;GO:0052742;GO:0016301;GO:0097159;GO:0036094;GO:0032550;GO:0001883;GO:0001882;GO:0032555;GO:0043167;GO:0043168; phosphatidylinositol phosphate kinase activity;nucleotide binding;transferase activity;carbohydrate derivative binding;molecular_function;binding;phosphatidylinositol 3-kinase activity;1-phosphatidylinositol-4-phosphate 3-kinase activity;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;ATP binding;phosphatidylinositol-4,5-bisphosphate 3-kinase activity;1-phosphatidylinositol-3-kinase activity;catalytic activity;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;phosphatidylinositol bisphosphate kinase activity;adenyl nucleotide binding;phosphatidylinositol kinase activity;kinase activity;organic cyclic compound binding;small molecule binding;purine ribonucleoside binding;purine nucleoside binding;nucleoside binding;purine ribonucleotide binding;ion binding;anion binding; 6;4;3;3;1;2;6;7;4;3;5;5;6;7;7;2;5;4;6;4;5;6;6;6;5;3;3;6;5;4;5;3;4; K00922 map00562;map04012;map04014;map04015;map04022;map04024;map04062;map04066;map04068;map04070;map04071;map04072;map04150;map04151;map04152;map04210;map04211;map04212;map04213;map04261;map04360;map04370;map04380;map04510;map04550;map04611;map04620;map04630;map04650;map04660;map04662;map04664;map04666;map04668;map04670;map04722;map04725;map04750;map04810;map04910;map04914;map04915;map04917;map04919;map04921;map04923;map04930;map04931;map04932;map04933;map04960;map04973;map05100;map05142;map05145;map05146;map05160;map05161;map05162;map05164;map05166;map05169;map05200;map05203;map05205;map05210;map05211;map05212;map05213;map05214;map05215;map05218;map05220;map05221;map05222;map05223;map05230;map05231; Inositol phosphate metabolism;ErbB signaling pathway;Ras signaling pathway;Rap1 signaling pathway;cGMP-PKG signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;HIF-1 signaling pathway;FoxO signaling pathway;Phosphatidylinositol signaling system;Sphingolipid signaling pathway;Phospholipase D signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Apoptosis;Longevity regulating pathway;Longevity regulating pathway - worm;Longevity regulating pathway - multiple species;Adrenergic signaling in cardiomyocytes;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Signaling pathways regulating pluripotency of stem cells;Platelet activation;Toll-like receptor signaling pathway;Jak-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;B cell receptor signaling pathway;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;TNF signaling pathway;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Cholinergic synapse;Inflammatory mediator regulation of TRP channels;Regulation of actin cytoskeleton;Insulin signaling pathway;Progesterone-mediated oocyte maturation;Estrogen signaling pathway;Prolactin signaling pathway;Thyroid hormone signaling pathway;Oxytocin signaling pathway;Regulation of lipolysis in adipocytes;Type II diabetes mellitus;Insulin resistance;Non-alcoholic fatty liver disease (NAFLD);AGE-RAGE signaling pathway in diabetic complications;Aldosterone-regulated sodium reabsorption;Carbohydrate digestion and absorption;Bacterial invasion of epithelial cells;Chagas disease (American trypanosomiasis);Toxoplasmosis;Amoebiasis;Hepatitis C;Hepatitis B;Measles;Influenza A;HTLV-I infection;Epstein-Barr virus infection;Pathways in cancer;Viral carcinogenesis;Proteoglycans in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Endometrial cancer;Glioma;Prostate cancer;Melanoma;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Non-small cell lung cancer;Central carbon metabolism in cancer;Choline metabolism in cancer; IPR016024;IPR000341;IPR011009;IPR002420;IPR029071;IPR018936;IPR001263;IPR000403;IPR003113;IPR000008;IPR015433; Armadillo-type fold;Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain;Protein kinase-like domain;Phosphatidylinositol 3-kinase, C2 domain;Ubiquitin-related domain;Phosphatidylinositol 3/4-kinase, conserved site;Phosphoinositide 3-kinase, accessory (PIK) domain;Phosphatidylinositol 3-/4-kinase, catalytic domain;Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain;C2 domain;Phosphatidylinositol kinase; cytosol Hs5453894 2223.0 T [T] Signal transduction mechanisms; P22891 Vitamin K-dependent protein Z OS=Homo sapiens OX=9606 GN=PROZ PE=1 SV=2 - [PROZ_HUMAN] 0.826 1.103 1.126 0.898 1.149 1.101 0.748866727 0.086610847 0.781549173 0.321120314 1.020852221 0.807397481 0.958224543 0.958488267 GO:0007599;GO:0007596;GO:0018214;GO:0009611;GO:0018193;GO:1901564;GO:0016192;GO:0044707;GO:0019538;GO:0017187;GO:0018200;GO:0006807;GO:0044267;GO:0006888;GO:0044260;GO:0065007;GO:0065008;GO:0006810;GO:0042060;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0051234;GO:0046907;GO:0050896;GO:0043412;GO:0036211;GO:0006518;GO:0034641;GO:0044699;GO:0006508;GO:0032501;GO:0050878;GO:0043687;GO:0009987;GO:0016485;GO:0051604;GO:0043603;GO:0043170;GO:0071704;GO:0010467;GO:0048193;GO:0006464;GO:0006465;GO:0044765;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:0044237;GO:1902582; hemostasis;blood coagulation;protein carboxylation;response to wounding;peptidyl-amino acid modification;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;peptidyl-glutamic acid carboxylation;peptidyl-glutamic acid modification;nitrogen compound metabolic process;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;biological regulation;regulation of biological quality;transport;wound healing;response to stress;coagulation;biological_process;metabolic process;establishment of localization;intracellular transport;response to stimulus;macromolecule modification;protein modification process;peptide metabolic process;cellular nitrogen compound metabolic process;single-organism process;proteolysis;multicellular organismal process;regulation of body fluid levels;post-translational protein modification;cellular process;protein processing;protein maturation;cellular amide metabolic process;macromolecule metabolic process;organic substance metabolic process;gene expression;Golgi vesicle transport;cellular protein modification process;signal peptide processing;single-organism transport;establishment of localization in cell;localization;single-organism localization;cellular localization;primary metabolic process;cellular metabolic process;single-organism intracellular transport; 5;5;7;4;7;4;5;3;4;8;8;3;5;7;4;2;3;4;5;3;4;1;2;3;5;2;5;5;5;4;2;5;2;4;7;2;6;5;5;4;3;5;6;6;6;4;4;2;3;3;3;3;5; GO:0005783;GO:0005788;GO:0031982;GO:0005794;GO:0005796;GO:0031974;GO:0043230;GO:0043231;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044432;GO:0044431;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0044464;GO:0005623;GO:0070062;GO:1903561;GO:0005575;GO:0070013;GO:0005576; endoplasmic reticulum;endoplasmic reticulum lumen;vesicle;Golgi apparatus;Golgi lumen;membrane-enclosed lumen;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endoplasmic reticulum part;Golgi apparatus part;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;cell part;cell;extracellular exosome;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 4;5;4;4;5;2;3;4;3;3;2;2;3;3;3;2;4;4;3;3;4;4;2;2;4;3;1;4;2; GO:0004252;GO:0046872;GO:0017171;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0005509;GO:0004175;GO:0070011; serine-type endopeptidase activity;metal ion binding;serine hydrolase activity;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;cation binding;ion binding;calcium ion binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;5;4;1;2;3;2;4;5;4;3;6;6;5; IPR000152;IPR001254;IPR000294;IPR017857;IPR009003;IPR000742;IPR001881;IPR013032; EGF-type aspartate/asparagine hydroxylation site;Serine proteases, trypsin domain;Gamma-carboxyglutamic acid-rich (GLA) domain;Coagulation factor, subgroup, Gla domain;Peptidase S1, PA clan;EGF-like domain;EGF-like calcium-binding domain;EGF-like, conserved site; extracellular Hs4506121 832.0 E [E] Amino acid transport and metabolism; Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo sapiens OX=9606 GN=ITIH3 PE=1 SV=2 - [ITIH3_HUMAN] 0.982 0.871 1.201 1.075 0.878 1.181 1.127439724 0.000887416 1.224373576 9.14E-12 1.378874856 1.02E-17 1.345102506 2.90E-10 GO:0030203;GO:0008152;GO:0019222;GO:0031324;GO:0031323;GO:1903510;GO:0050789;GO:0006807;GO:0009892;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0030212;GO:0009987;GO:0052547;GO:0052548;GO:0050794;GO:0008150;GO:0010951;GO:0051346;GO:0006508;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:1901564;GO:0050790;GO:0060255;GO:1901135;GO:0044237;GO:0043170;GO:0019538;GO:0006022;GO:0030162;GO:0045861;GO:0048523; glycosaminoglycan metabolic process;metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mucopolysaccharide metabolic process;regulation of biological process;nitrogen compound metabolic process;negative regulation of metabolic process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;hyaluronan metabolic process;cellular process;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular process;biological_process;negative regulation of endopeptidase activity;negative regulation of hydrolase activity;proteolysis;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;organonitrogen compound metabolic process;regulation of catalytic activity;regulation of macromolecule metabolic process;carbohydrate derivative metabolic process;cellular metabolic process;macromolecule metabolic process;protein metabolic process;aminoglycan metabolic process;regulation of proteolysis;negative regulation of proteolysis;negative regulation of cellular process; 6;2;3;4;4;7;2;3;3;4;5;5;4;4;5;5;3;7;2;4;2;3;8;2;6;7;3;1;8;6;5;5;3;5;5;4;4;4;4;3;4;4;5;6;6;3; GO:0043227;GO:0043226;GO:0070062;GO:0043230;GO:1903561;GO:0031982;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular organelle;extracellular vesicle;vesicle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;4;1;2;2; GO:0030414;GO:0003674;GO:0004857;GO:0098772;GO:0061135;GO:0030234;GO:0061134;GO:0004866;GO:0004867; peptidase inhibitor activity;molecular_function;enzyme inhibitor activity;molecular function regulator;endopeptidase regulator activity;enzyme regulator activity;peptidase regulator activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity; 5;1;4;2;5;3;4;6;7; IPR013694;IPR002035;IPR010600; VIT domain;von Willebrand factor, type A;Inter-alpha-trypsin inhibitor heavy chain, C-terminal; endoplasmic reticulum 430742747 174.0 R [R] General function prediction only; COG2304 Secreted protein containing bacterial Ig-like domain and vWFA domain A0A0C4DH67 Immunoglobulin kappa variable 1-8 OS=Homo sapiens OX=9606 GN=IGKV1-8 PE=3 SV=1 - [KV108_HUMAN] 0.984 1.263 0.768 1 1.219 1.119 0.779097387 0.01903839 0.820344545 0.00521931 0.60807601 0.000825091 0.917965546 0.120505424 IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q99972 Myocilin OS=Homo sapiens OX=9606 GN=MYOC PE=1 SV=2 - [MYOC_HUMAN] 1.373 1.077 0.476 1.645 0.885 0.797 1.274837512 nan 1.858757062 nan 0.441968431 nan 0.900564972 nan GO:0003254;GO:0019220;GO:0080090;GO:0019222;GO:0034446;GO:1901890;GO:0048584;GO:0048583;GO:0051493;GO:0022011;GO:0001501;GO:0043933;GO:0001503;GO:0007165;GO:0007166;GO:0007167;GO:0051893;GO:0007169;GO:0032989;GO:0051897;GO:0051896;GO:0023014;GO:0032231;GO:0051716;GO:0014066;GO:0014037;GO:0009968;GO:0045785;GO:0009966;GO:0048869;GO:0051495;GO:0000165;GO:0051492;GO:0048513;GO:0010720;GO:0048518;GO:0048519;GO:0051094;GO:0048585;GO:0035024;GO:0031589;GO:0014734;GO:1901888;GO:0060255;GO:0048468;GO:0008366;GO:0051901;GO:0035567;GO:0003008;GO:0042325;GO:0044700;GO:0016477;GO:0044707;GO:0044089;GO:0019538;GO:0016055;GO:0010638;GO:0010639;GO:0048878;GO:0051272;GO:0065008;GO:0010770;GO:0010648;GO:0022604;GO:0042391;GO:0022607;GO:2000021;GO:0021782;GO:0022603;GO:0007264;GO:0035023;GO:0030335;GO:0006928;GO:0051674;GO:1903393;GO:0031175;GO:0035556;GO:0050789;GO:0044267;GO:0038129;GO:0042552;GO:0030029;GO:0044260;GO:0042551;GO:0007266;GO:0016043;GO:0090109;GO:1904181;GO:0051129;GO:0065007;GO:0071840;GO:0014896;GO:0051894;GO:0043149;GO:0051130;GO:0042063;GO:0098602;GO:0050793;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0032956;GO:1902532;GO:1902533;GO:1902531;GO:0048015;GO:0060284;GO:0048017;GO:0044767;GO:1903391;GO:0045162;GO:0000904;GO:0043491;GO:0050896;GO:0048469;GO:0014897;GO:2000145;GO:0007160;GO:0009967;GO:0044802;GO:0001954;GO:0051494;GO:0061572;GO:0033043;GO:0016310;GO:0030155;GO:0030154;GO:0046578;GO:0051128;GO:0023056;GO:0023057;GO:0007045;GO:0007044;GO:0023052;GO:0038127;GO:0010001;GO:0023051;GO:0001953;GO:0010647;GO:0010646;GO:0045595;GO:0007265;GO:0044699;GO:0043408;GO:0014888;GO:0009653;GO:1900024;GO:0051246;GO:0034333;GO:0007162;GO:0010769;GO:0031399;GO:0022610;GO:0000902;GO:0051899;GO:0032502;GO:0038031;GO:0032501;GO:0032292;GO:0007015;GO:0009987;GO:0051017;GO:0051496;GO:0045597;GO:0038133;GO:0040012;GO:0040011;GO:0045216;GO:0014065;GO:0051882;GO:0038128;GO:0032879;GO:0034329;GO:0030334;GO:0032268;GO:0040017;GO:0051058;GO:0050801;GO:0007422;GO:0001952;GO:0043170;GO:0061024;GO:0051900;GO:0048731;GO:1900026;GO:0030038;GO:0038030;GO:0031032;GO:0048870;GO:0030030;GO:0034332;GO:0031323;GO:0030036;GO:0060348;GO:0042592;GO:0034330;GO:0048041;GO:0007272;GO:0007275;GO:0001649;GO:0043501;GO:0071822;GO:0021700;GO:1902589;GO:0032844;GO:0071704;GO:0003012;GO:0043500;GO:0051497;GO:0048666;GO:0006468;GO:0032970;GO:2000147;GO:0030182;GO:0010810;GO:0010811;GO:0010812;GO:0006464;GO:0051174;GO:0032233;GO:0032232;GO:0014044;GO:0044763;GO:0046580;GO:0014068;GO:0007155;GO:0007154;GO:0022008;GO:0051179;GO:0006996;GO:0044238;GO:0048699;GO:0051270;GO:0007010;GO:0051881;GO:0007399;GO:0048856;GO:0045161;GO:0044237;GO:0044087;GO:0006796;GO:0044085;GO:0051056;GO:0006793;GO:0001932;GO:0048523;GO:0048522; regulation of membrane depolarization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;substrate adhesion-dependent cell spreading;positive regulation of cell junction assembly;positive regulation of response to stimulus;regulation of response to stimulus;regulation of cytoskeleton organization;myelination in peripheral nervous system;skeletal system development;macromolecular complex subunit organization;ossification;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;regulation of focal adhesion assembly;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component morphogenesis;positive regulation of protein kinase B signaling;regulation of protein kinase B signaling;signal transduction by protein phosphorylation;regulation of actin filament bundle assembly;cellular response to stimulus;regulation of phosphatidylinositol 3-kinase signaling;Schwann cell differentiation;negative regulation of signal transduction;positive regulation of cell adhesion;regulation of signal transduction;cellular developmental process;positive regulation of cytoskeleton organization;MAPK cascade;regulation of stress fiber assembly;animal organ development;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;positive regulation of developmental process;negative regulation of response to stimulus;negative regulation of Rho protein signal transduction;cell-substrate adhesion;skeletal muscle hypertrophy;regulation of cell junction assembly;regulation of macromolecule metabolic process;cell development;axon ensheathment;positive regulation of mitochondrial depolarization;non-canonical Wnt signaling pathway;system process;regulation of phosphorylation;single organism signaling;cell migration;single-multicellular organism process;positive regulation of cellular component biogenesis;protein metabolic process;Wnt signaling pathway;positive regulation of organelle organization;negative regulation of organelle organization;chemical homeostasis;positive regulation of cellular component movement;regulation of biological quality;positive regulation of cell morphogenesis involved in differentiation;negative regulation of cell communication;regulation of cell morphogenesis;regulation of membrane potential;cellular component assembly;regulation of ion homeostasis;glial cell development;regulation of anatomical structure morphogenesis;small GTPase mediated signal transduction;regulation of Rho protein signal transduction;positive regulation of cell migration;movement of cell or subcellular component;localization of cell;positive regulation of adherens junction organization;neuron projection development;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;ERBB3 signaling pathway;myelination;actin filament-based process;cellular macromolecule metabolic process;neuron maturation;Rho protein signal transduction;cellular component organization;regulation of cell-substrate junction assembly;positive regulation of membrane depolarization;negative regulation of cellular component organization;biological regulation;cellular component organization or biogenesis;muscle hypertrophy;positive regulation of focal adhesion assembly;stress fiber assembly;positive regulation of cellular component organization;gliogenesis;single organism cell adhesion;regulation of developmental process;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;regulation of actin cytoskeleton organization;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;phosphatidylinositol-mediated signaling;regulation of cell development;inositol lipid-mediated signaling;single-organism developmental process;regulation of adherens junction organization;clustering of voltage-gated sodium channels;cell morphogenesis involved in differentiation;protein kinase B signaling;response to stimulus;cell maturation;striated muscle hypertrophy;regulation of cell motility;cell-matrix adhesion;positive regulation of signal transduction;single-organism membrane organization;positive regulation of cell-matrix adhesion;negative regulation of cytoskeleton organization;actin filament bundle organization;regulation of organelle organization;phosphorylation;regulation of cell adhesion;cell differentiation;regulation of Ras protein signal transduction;regulation of cellular component organization;positive regulation of signaling;negative regulation of signaling;cell-substrate adherens junction assembly;cell-substrate junction assembly;signaling;ERBB signaling pathway;glial cell differentiation;regulation of signaling;negative regulation of cell-matrix adhesion;positive regulation of cell communication;regulation of cell communication;regulation of cell differentiation;Ras protein signal transduction;single-organism process;regulation of MAPK cascade;striated muscle adaptation;anatomical structure morphogenesis;regulation of substrate adhesion-dependent cell spreading;regulation of protein metabolic process;adherens junction assembly;negative regulation of cell adhesion;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;biological adhesion;cell morphogenesis;membrane depolarization;developmental process;non-canonical Wnt signaling pathway via JNK cascade;multicellular organismal process;peripheral nervous system axon ensheathment;actin filament organization;cellular process;actin filament bundle assembly;positive regulation of stress fiber assembly;positive regulation of cell differentiation;ERBB2-ERBB3 signaling pathway;regulation of locomotion;locomotion;cell-cell junction organization;phosphatidylinositol 3-kinase signaling;mitochondrial depolarization;ERBB2 signaling pathway;regulation of localization;cell junction assembly;regulation of cell migration;regulation of cellular protein metabolic process;positive regulation of locomotion;negative regulation of small GTPase mediated signal transduction;ion homeostasis;peripheral nervous system development;regulation of cell-matrix adhesion;macromolecule metabolic process;membrane organization;regulation of mitochondrial depolarization;system development;positive regulation of substrate adhesion-dependent cell spreading;contractile actin filament bundle assembly;non-canonical Wnt signaling pathway via MAPK cascade;actomyosin structure organization;cell motility;cell projection organization;adherens junction organization;regulation of cellular metabolic process;actin cytoskeleton organization;bone development;homeostatic process;cell junction organization;focal adhesion assembly;ensheathment of neurons;multicellular organism development;osteoblast differentiation;skeletal muscle adaptation;protein complex subunit organization;developmental maturation;single-organism organelle organization;regulation of homeostatic process;organic substance metabolic process;muscle system process;muscle adaptation;negative regulation of stress fiber assembly;neuron development;protein phosphorylation;regulation of actin filament-based process;positive regulation of cell motility;neuron differentiation;regulation of cell-substrate adhesion;positive regulation of cell-substrate adhesion;negative regulation of cell-substrate adhesion;cellular protein modification process;regulation of phosphorus metabolic process;positive regulation of actin filament bundle assembly;negative regulation of actin filament bundle assembly;Schwann cell development;single-organism cellular process;negative regulation of Ras protein signal transduction;positive regulation of phosphatidylinositol 3-kinase signaling;cell adhesion;cell communication;neurogenesis;localization;organelle organization;primary metabolic process;generation of neurons;regulation of cellular component movement;cytoskeleton organization;regulation of mitochondrial membrane potential;nervous system development;anatomical structure development;neuronal ion channel clustering;cellular metabolic process;regulation of cellular component biogenesis;phosphate-containing compound metabolic process;cellular component biogenesis;regulation of small GTPase mediated signal transduction;phosphorus metabolic process;regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 4;6;4;3;4;4;3;3;6;7;5;4;4;4;5;6;6;7;4;6;6;4;4;3;6;6;4;4;4;4;6;5;5;4;5;2;2;3;3;8;4;6;4;4;4;5;4;7;3;7;3;4;3;3;4;6;5;5;5;4;3;5;4;5;4;4;4;5;4;6;8;5;4;3;5;5;5;2;5;9;6;4;4;6;8;3;5;3;4;2;2;5;5;7;4;7;3;3;3;3;5;5;1;2;5;5;5;5;7;5;6;3;5;6;5;6;2;5;6;4;5;4;4;6;6;7;5;6;4;5;7;4;3;3;7;6;2;8;6;3;6;4;4;4;7;2;6;4;3;5;5;6;4;6;6;2;5;5;2;9;2;6;6;2;5;5;4;10;3;2;5;8;6;9;3;5;5;5;3;6;6;5;6;4;4;5;4;5;6;8;6;3;4;6;4;5;4;4;4;6;4;4;5;5;5;4;4;3;3;4;3;6;5;7;4;4;6;5;5;5;6;5;4;5;6;3;7;6;3;4;6;2;4;3;7;4;5;5;5;3;5;3;3;5;3;6;4;7;3;3; GO:0031970;GO:0031974;GO:0031975;GO:0005783;GO:0016020;GO:0031988;GO:0005794;GO:0005791;GO:0098588;GO:0031967;GO:0031966;GO:0042995;GO:0043230;GO:0043231;GO:0044429;GO:0044424;GO:0031012;GO:0044421;GO:0044422;GO:0019866;GO:0043229;GO:0005622;GO:0043227;GO:0012505;GO:0031982;GO:0031968;GO:0044446;GO:0016023;GO:0044444;GO:0033268;GO:0097708;GO:0097458;GO:0044463;GO:0005737;GO:0031090;GO:0031410;GO:0005739;GO:0043005;GO:0019867;GO:0044464;GO:0005623;GO:0005743;GO:0005740;GO:0005741;GO:0005929;GO:0044304;GO:0005615;GO:0098805;GO:0043226;GO:0005576;GO:0030424;GO:0005758;GO:0033267;GO:1903561;GO:0070062;GO:0005575;GO:0005578; organelle envelope lumen;membrane-enclosed lumen;envelope;endoplasmic reticulum;membrane;membrane-bounded vesicle;Golgi apparatus;rough endoplasmic reticulum;bounding membrane of organelle;organelle envelope;mitochondrial membrane;cell projection;extracellular organelle;intracellular membrane-bounded organelle;mitochondrial part;intracellular part;extracellular matrix;extracellular region part;organelle part;organelle inner membrane;intracellular organelle;intracellular;membrane-bounded organelle;endomembrane system;vesicle;organelle outer membrane;intracellular organelle part;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;node of Ranvier;intracellular vesicle;neuron part;cell projection part;cytoplasm;organelle membrane;cytoplasmic vesicle;mitochondrion;neuron projection;outer membrane;cell part;cell;mitochondrial inner membrane;mitochondrial envelope;mitochondrial outer membrane;cilium;main axon;extracellular space;whole membrane;organelle;extracellular region;axon;mitochondrial intermembrane space;axon part;extracellular vesicle;extracellular exosome;cellular_component;proteinaceous extracellular matrix; 3;2;3;4;2;5;4;5;4;4;4;3;3;4;4;3;2;2;2;4;3;3;3;3;4;4;3;5;4;5;4;3;3;4;3;5;5;4;3;2;2;5;5;5;3;5;3;3;2;2;5;4;4;3;4;1;3; GO:0032027;GO:0046872;GO:0003674;GO:0005488;GO:0001968;GO:0008092;GO:0017022;GO:0043169;GO:0043167;GO:0005109;GO:0005515;GO:0005102;GO:0001664; myosin light chain binding;metal ion binding;molecular_function;binding;fibronectin binding;cytoskeletal protein binding;myosin binding;cation binding;ion binding;frizzled binding;protein binding;receptor binding;G-protein coupled receptor binding; 6;5;1;2;4;4;5;4;3;6;3;4;5; K23027 IPR031213;IPR003112; Myocilin;Olfactomedin-like domain; extracellular Hs4557779 1043.0 W [W] Extracellular structures; Q63HN8 E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3 - [RN213_HUMAN] 1.004 1.144 1.422 0.725 0.819 0.802 0.877622378 nan 0.885225885 nan 1.243006993 nan 0.979242979 nan GO:0048585;GO:0048583;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:0044707;GO:0071840;GO:0051716;GO:0009968;GO:0009966;GO:0070647;GO:0032446;GO:0048514;GO:0048519;GO:0030163;GO:0035567;GO:0044700;GO:0019538;GO:0016055;GO:0030111;GO:0016567;GO:0051865;GO:0022607;GO:0043170;GO:0050789;GO:0044267;GO:1901575;GO:0010646;GO:0044260;GO:0001568;GO:0016043;GO:0065003;GO:0065007;GO:0002040;GO:0048646;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051603;GO:0050896;GO:0006511;GO:0070271;GO:0044248;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0009653;GO:0044699;GO:0001944;GO:0006508;GO:0032502;GO:0032501;GO:0030178;GO:0009987;GO:0019941;GO:0044257;GO:0051259;GO:0048731;GO:0043933;GO:0043632;GO:0001525;GO:0007275;GO:2000051;GO:2000050;GO:0051260;GO:0071704;GO:0006461;GO:0006464;GO:0044767;GO:0044265;GO:0044763;GO:0007154;GO:0009056;GO:0009057;GO:0044238;GO:0071822;GO:0048856;GO:0044237;GO:0044085;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;single-multicellular organism process;cellular component organization or biogenesis;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;protein modification by small protein conjugation or removal;protein modification by small protein conjugation;blood vessel morphogenesis;negative regulation of biological process;protein catabolic process;non-canonical Wnt signaling pathway;single organism signaling;protein metabolic process;Wnt signaling pathway;regulation of Wnt signaling pathway;protein ubiquitination;protein autoubiquitination;cellular component assembly;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;organic substance catabolic process;regulation of cell communication;cellular macromolecule metabolic process;blood vessel development;cellular component organization;macromolecular complex assembly;biological regulation;sprouting angiogenesis;anatomical structure formation involved in morphogenesis;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;proteolysis involved in cellular protein catabolic process;response to stimulus;ubiquitin-dependent protein catabolic process;protein complex biogenesis;cellular catabolic process;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;anatomical structure morphogenesis;single-organism process;vasculature development;proteolysis;developmental process;multicellular organismal process;negative regulation of Wnt signaling pathway;cellular process;modification-dependent protein catabolic process;cellular protein catabolic process;protein oligomerization;system development;macromolecular complex subunit organization;modification-dependent macromolecule catabolic process;angiogenesis;multicellular organism development;negative regulation of non-canonical Wnt signaling pathway;regulation of non-canonical Wnt signaling pathway;protein homooligomerization;organic substance metabolic process;protein complex assembly;cellular protein modification process;single-organism developmental process;cellular macromolecule catabolic process;single-organism cellular process;cell communication;catabolic process;macromolecule catabolic process;primary metabolic process;protein complex subunit organization;anatomical structure development;cellular metabolic process;cellular component biogenesis;negative regulation of cellular process; 3;3;5;5;4;5;3;2;3;4;4;7;8;4;2;5;7;3;4;6;5;9;10;4;4;2;5;4;4;4;4;3;5;2;5;3;3;5;5;1;2;6;2;8;4;4;3;2;4;3;3;2;5;5;2;2;5;2;7;6;6;4;4;6;4;4;6;6;7;3;5;6;3;5;3;4;3;5;3;5;3;3;3;3; GO:0031974;GO:0016020;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0031981;GO:0044446;GO:0044444;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;membrane;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;nuclear lumen;intracellular organelle part;cytoplasmic part;cytoplasm;nucleolus;nucleus;cell part;cell;intracellular;organelle;cellular_component;intracellular organelle lumen; 2;2;4;4;3;5;4;3;2;3;3;3;5;3;4;4;5;5;2;2;3;2;1;4; GO:0046914;GO:0016740;GO:0046872;GO:0016818;GO:0008270;GO:0016787;GO:0016817;GO:0003674;GO:0005488;GO:0016887;GO:0019787;GO:0003824;GO:0004842;GO:0016462;GO:0043169;GO:0016874;GO:0043167;GO:0017111; transition metal ion binding;transferase activity;metal ion binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;zinc ion binding;hydrolase activity;hydrolase activity, acting on acid anhydrides;molecular_function;binding;ATPase activity;ubiquitin-like protein transferase activity;catalytic activity;ubiquitin-protein transferase activity;pyrophosphatase activity;cation binding;ligase activity;ion binding;nucleoside-triphosphatase activity; 6;3;5;5;7;3;4;1;2;8;4;2;5;6;4;3;3;7; K22754 IPR018957;IPR031248;IPR003593;IPR013083;IPR001841;IPR027417; Zinc finger, C3HC4 RING-type;RNF213 protein;AAA+ ATPase domain;Zinc finger, RING/FYVE/PHD-type;Zinc finger, RING-type;P-loop containing nucleoside triphosphate hydrolase; plasma membrane Q9H8L6 Multimerin-2 OS=Homo sapiens OX=9606 GN=MMRN2 PE=1 SV=2 - [MMRN2_HUMAN] 1.06 1.01 0.931 0.91 0.995 1.971 1.049504951 nan 0.914572864 nan 0.921782178 nan 1.980904523 nan GO:0048585;GO:0048583;GO:0072359;GO:0072358;GO:0007165;GO:0007166;GO:1903671;GO:0007169;GO:0051716;GO:0009968;GO:0009966;GO:0070848;GO:0048514;GO:0048519;GO:0043537;GO:0043535;GO:0043534;GO:0010033;GO:0044700;GO:0010631;GO:0044707;GO:0010633;GO:0048870;GO:0007154;GO:0002042;GO:1903670;GO:0022603;GO:0007167;GO:0006928;GO:1901342;GO:1901343;GO:0043542;GO:0009653;GO:0001568;GO:0051270;GO:0065007;GO:0016477;GO:0002040;GO:0048646;GO:0050793;GO:0050794;GO:0008150;GO:0051239;GO:0048010;GO:0030947;GO:0030948;GO:0050896;GO:0090051;GO:2000145;GO:2000146;GO:0023057;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0001667;GO:0010646;GO:0044699;GO:0090287;GO:0090049;GO:0051241;GO:0001944;GO:0090288;GO:0010632;GO:0032502;GO:0032501;GO:0009987;GO:0040013;GO:0040012;GO:0032879;GO:0090132;GO:0090130;GO:0051093;GO:0071363;GO:0051674;GO:0048731;GO:0016525;GO:2000181;GO:0001525;GO:0007275;GO:0045765;GO:0050789;GO:0071310;GO:0030336;GO:0030334;GO:0044767;GO:0044763;GO:0042221;GO:0051179;GO:0040011;GO:0051271;GO:0010594;GO:0010596;GO:0048856;GO:2000026;GO:0048523; negative regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;signal transduction;cell surface receptor signaling pathway;negative regulation of sprouting angiogenesis;transmembrane receptor protein tyrosine kinase signaling pathway;cellular response to stimulus;negative regulation of signal transduction;regulation of signal transduction;response to growth factor;blood vessel morphogenesis;negative regulation of biological process;negative regulation of blood vessel endothelial cell migration;regulation of blood vessel endothelial cell migration;blood vessel endothelial cell migration;response to organic substance;single organism signaling;epithelial cell migration;single-multicellular organism process;negative regulation of epithelial cell migration;cell motility;cell communication;cell migration involved in sprouting angiogenesis;regulation of sprouting angiogenesis;regulation of anatomical structure morphogenesis;enzyme linked receptor protein signaling pathway;movement of cell or subcellular component;regulation of vasculature development;negative regulation of vasculature development;endothelial cell migration;anatomical structure morphogenesis;blood vessel development;regulation of cellular component movement;biological regulation;cell migration;sprouting angiogenesis;anatomical structure formation involved in morphogenesis;regulation of developmental process;regulation of cellular process;biological_process;regulation of multicellular organismal process;vascular endothelial growth factor receptor signaling pathway;regulation of vascular endothelial growth factor receptor signaling pathway;negative regulation of vascular endothelial growth factor receptor signaling pathway;response to stimulus;negative regulation of cell migration involved in sprouting angiogenesis;regulation of cell motility;negative regulation of cell motility;negative regulation of signaling;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;ameboidal-type cell migration;regulation of cell communication;single-organism process;regulation of cellular response to growth factor stimulus;regulation of cell migration involved in sprouting angiogenesis;negative regulation of multicellular organismal process;vasculature development;negative regulation of cellular response to growth factor stimulus;regulation of epithelial cell migration;developmental process;multicellular organismal process;cellular process;negative regulation of locomotion;regulation of locomotion;regulation of localization;epithelium migration;tissue migration;negative regulation of developmental process;cellular response to growth factor stimulus;localization of cell;system development;negative regulation of angiogenesis;negative regulation of blood vessel morphogenesis;angiogenesis;multicellular organism development;regulation of angiogenesis;regulation of biological process;cellular response to organic substance;negative regulation of cell migration;regulation of cell migration;single-organism developmental process;single-organism cellular process;response to chemical;localization;locomotion;negative regulation of cellular component movement;regulation of endothelial cell migration;negative regulation of endothelial cell migration;anatomical structure development;regulation of multicellular organismal development;negative regulation of cellular process; 3;3;5;5;4;5;6;7;3;4;4;5;4;2;6;6;8;4;3;6;3;4;3;4;6;6;4;6;4;5;4;7;3;4;4;2;4;5;3;3;3;1;3;8;5;5;2;7;4;4;3;2;4;4;3;5;4;2;4;7;3;5;4;4;2;2;2;3;3;3;5;4;3;6;3;4;5;5;4;4;5;2;5;5;5;3;3;3;2;2;4;5;5;3;4;3; GO:0031982;GO:0043230;GO:0044420;GO:0044421;GO:0043227;GO:0043226;GO:0031012;GO:0070062;GO:1903561;GO:0005615;GO:0005604;GO:0005575;GO:0005576;GO:0005578; vesicle;extracellular organelle;extracellular matrix component;extracellular region part;membrane-bounded organelle;organelle;extracellular matrix;extracellular exosome;extracellular vesicle;extracellular space;basement membrane;cellular_component;extracellular region;proteinaceous extracellular matrix; 4;3;2;2;3;2;2;4;3;3;3;1;2;3; IPR008983;IPR011489;IPR001073; Tumour necrosis factor-like domain;EMI domain;C1q domain; extracellular Q13753 Laminin subunit gamma-2 OS=Homo sapiens OX=9606 GN=LAMC2 PE=1 SV=2 - [LAMC2_HUMAN] 0.64 0.741 2.289 0.76 0.514 0.836 0.863697706 0.600500811 1.478599222 0.91614068 3.089068826 0.261346134 1.626459144 0.425367955 GO:0022607;GO:0060429;GO:0034330;GO:0007155;GO:0007044;GO:0044699;GO:0008544;GO:0016043;GO:0044085;GO:0071840;GO:0030198;GO:0022610;GO:0022617;GO:0032502;GO:0043062;GO:0031581;GO:0009987;GO:0009888;GO:0008150;GO:0034329;GO:0048856;GO:0022411;GO:0044763; cellular component assembly;epithelium development;cell junction organization;cell adhesion;cell-substrate junction assembly;single-organism process;epidermis development;cellular component organization;cellular component biogenesis;cellular component organization or biogenesis;extracellular matrix organization;biological adhesion;extracellular matrix disassembly;developmental process;extracellular structure organization;hemidesmosome assembly;cellular process;tissue development;biological_process;cell junction assembly;anatomical structure development;cellular component disassembly;single-organism cellular process; 4;5;4;3;6;2;6;3;3;2;5;2;5;2;4;7;2;4;1;5;3;4;3; GO:0031012;GO:0005622;GO:0005737;GO:0005615;GO:0016020;GO:0048471;GO:0043234;GO:0099568;GO:0071944;GO:0005938;GO:0043256;GO:0005607;GO:0005605;GO:0005604;GO:0032991;GO:0044464;GO:0005623;GO:0044421;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044420;GO:0005578; extracellular matrix;intracellular;cytoplasm;extracellular space;membrane;perinuclear region of cytoplasm;protein complex;cytoplasmic region;cell periphery;cell cortex;laminin complex;laminin-2 complex;basal lamina;basement membrane;macromolecular complex;cell part;cell;extracellular region part;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular matrix component;proteinaceous extracellular matrix; 2;3;4;3;2;5;3;5;3;4;3;4;3;3;2;2;2;2;1;4;2;3;2;3; GO:0003674;GO:0005488;GO:0043168;GO:0005539;GO:0043167;GO:0008201;GO:0097367;GO:1901681; molecular_function;binding;anion binding;glycosaminoglycan binding;ion binding;heparin binding;carbohydrate derivative binding;sulfur compound binding; 1;2;4;4;3;4;3;3; K06246 map04151;map04510;map04512;map05145;map05146;map05200;map05222; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Toxoplasmosis;Amoebiasis;Pathways in cancer;Small cell lung cancer; IPR031082;IPR000034;IPR000742;IPR002049; Laminin subunit gamma;Laminin IV;EGF-like domain;Laminin EGF domain; extracellular Hs5031847 2470.0 W [W] Extracellular structures; Q92786 Prospero homeobox protein 1 OS=Homo sapiens OX=9606 GN=PROX1 PE=1 SV=2 - [PROX1_HUMAN] 1.196 0.946 0.836 1.232 0.999 1.125 1.264270613 0.083730182 1.233233233 0.163875585 0.88372093 0.156584541 1.126126126 0.287170531 GO:0044281;GO:0044283;GO:0019222;GO:0003157;GO:0003159;GO:0003158;GO:0051495;GO:0030910;GO:0051493;GO:0030916;GO:0030855;GO:0071600;GO:0060541;GO:0045859;GO:0046483;GO:0010634;GO:0042327;GO:0010631;GO:0009605;GO:0019538;GO:0010638;GO:0060838;GO:0060322;GO:0042692;GO:0021537;GO:0048562;GO:0021533;GO:0009893;GO:0009890;GO:0009891;GO:0048568;GO:0031076;GO:0071902;GO:0071900;GO:0050789;GO:0003205;GO:0003206;GO:0051347;GO:0000902;GO:0003209;GO:0003208;GO:0071840;GO:0018130;GO:0007623;GO:0006629;GO:0021542;GO:0021543;GO:0043412;GO:0072148;GO:0032956;GO:0021549;GO:0016070;GO:0010557;GO:0010556;GO:0006694;GO:0006699;GO:0035909;GO:0010558;GO:0002194;GO:0048639;GO:0048638;GO:0051246;GO:0051128;GO:0021766;GO:2000979;GO:0021761;GO:2000977;GO:0010632;GO:0045927;GO:0051247;GO:0000122;GO:0045071;GO:0060284;GO:0048513;GO:0070365;GO:0008284;GO:0055001;GO:0055002;GO:0055003;GO:0055005;GO:0055006;GO:0008283;GO:0055008;GO:0055009;GO:0051153;GO:0001654;GO:0001655;GO:0051155;GO:0001932;GO:0022402;GO:0031032;GO:0030036;GO:0001889;GO:0002088;GO:0002089;GO:0045446;GO:0046619;GO:0007275;GO:2000112;GO:2000113;GO:0048598;GO:0006468;GO:0021915;GO:0019216;GO:0019219;GO:0019218;GO:0048592;GO:0048593;GO:0048596;GO:0044767;GO:0044764;GO:0044763;GO:0040011;GO:0051272;GO:0051270;GO:0010595;GO:0010594;GO:0040017;GO:0048856;GO:0042752;GO:0006796;GO:2000026;GO:0006793;GO:0048525;GO:0048523;GO:0048522;GO:0044710;GO:0044711;GO:0045787;GO:0043433;GO:0045664;GO:0045666;GO:0044093;GO:0044092;GO:0021696;GO:0021697;GO:0021695;GO:0002067;GO:0002064;GO:0002065;GO:0042325;GO:0051055;GO:2001141;GO:0051704;GO:0019827;GO:0003160;GO:0009790;GO:0031667;GO:1904029;GO:0061008;GO:0022037;GO:0010629;GO:0006807;GO:0044267;GO:0044260;GO:0001568;GO:0044699;GO:0006366;GO:0009887;GO:0050793;GO:0050792;GO:0050790;GO:0009889;GO:0009888;GO:0050794;GO:0006464;GO:0051239;GO:0003230;GO:0003231;GO:0051174;GO:0046394;GO:0050896;GO:0003279;GO:0051338;GO:0051962;GO:0051960;GO:2000145;GO:2000147;GO:0043010;GO:0010562;GO:0033043;GO:0010564;GO:0010565;GO:0060850;GO:0009892;GO:0032268;GO:0007049;GO:0050767;GO:0051240;GO:0033674;GO:0001944;GO:0001945;GO:0001946;GO:0050769;GO:0031399;GO:0021953;GO:0070309;GO:0070306;GO:0070307;GO:0040012;GO:0090132;GO:0090130;GO:0060298;GO:0045069;GO:0060297;GO:1902680;GO:0048731;GO:0048732;GO:0055015;GO:0030323;GO:0030324;GO:0055012;GO:0055010;GO:0043933;GO:0030240;GO:0060059;GO:0014706;GO:0060421;GO:0001763;GO:0051147;GO:0051146;GO:0051149;GO:0036303;GO:0048048;GO:0072330;GO:0043584;GO:0043583;GO:0061351;GO:0045935;GO:0045934;GO:0030029;GO:0061138;GO:0046620;GO:0046622;GO:0035051;GO:0000904;GO:0022008;GO:0008610;GO:0006996;GO:0044238;GO:0044237;GO:0060537;GO:0044403;GO:0019220;GO:0048589;GO:0050679;GO:0021516;GO:0048468;GO:0021510;GO:0072359;GO:0072358;GO:1901362;GO:1901360;GO:0048869;GO:0001822;GO:0048511;GO:0019058;GO:0048514;GO:0010720;GO:0048518;GO:0048519;GO:0042127;GO:0003007;GO:0071699;GO:0071698;GO:0043436;GO:0071697;GO:0071696;GO:0044707;GO:0016053;GO:0021684;GO:0060788;GO:0021681;GO:0021683;GO:0022607;GO:0022603;GO:0006928;GO:0051674;GO:0021707;GO:0097659;GO:0043542;GO:0048738;GO:0043549;GO:0008285;GO:1904031;GO:0016477;GO:0048644;GO:0048646;GO:1904251;GO:1904252;GO:0043903;GO:0043900;GO:0043901;GO:0050810;GO:0034654;GO:0097150;GO:0044271;GO:0007420;GO:0007423;GO:0072574;GO:0031401;GO:0006355;GO:0006357;GO:0006351;GO:1901617;GO:1901615;GO:0032774;GO:0030154;GO:0010927;GO:0060041;GO:0060042;GO:0003228;GO:0061061;GO:0055013;GO:0006139;GO:0001709;GO:2000177;GO:0032270;GO:0043009;GO:2000179;GO:0032502;GO:0032501;GO:0032970;GO:0006725;GO:1903506;GO:1903507;GO:0060214;GO:0072001;GO:0032879;GO:0072576;GO:0048839;GO:0050678;GO:0072575;GO:0051253;GO:0051252;GO:0051254;GO:0050673;GO:0007507;GO:0046890;GO:0043170;GO:0045937;GO:0032989;GO:0071704;GO:0048729;GO:0090596;GO:0030335;GO:0030334;GO:0030239;GO:0035904;GO:1902679;GO:0009058;GO:0009059;GO:0045939;GO:0051171;GO:0051172;GO:0051173;GO:0070925;GO:0051179;GO:0042180;GO:0000075;GO:0051726;GO:0000079;GO:1902589;GO:0030900;GO:0030902;GO:0048844;GO:0048845;GO:0080090;GO:0035265;GO:0001743;GO:0007517;GO:0070857;GO:0010605;GO:0010604;GO:0043049;GO:0090068;GO:0044419;GO:0045833;GO:0010894;GO:0031016;GO:0060255;GO:0021879;GO:0032787;GO:0060900;GO:0090425;GO:0048870;GO:0060419;GO:0019438;GO:0060411;GO:0060415;GO:0060414;GO:0003229;GO:1901576;GO:0030182;GO:0016043;GO:0071599;GO:0060836;GO:0065007;GO:0065009;GO:0060839;GO:0051130;GO:0098727;GO:0036211;GO:0008150;GO:0008152;GO:0060412;GO:0045165;GO:1901978;GO:0045737;GO:1901976;GO:0016310;GO:0044249;GO:0034641;GO:0009792;GO:0034645;GO:0001667;GO:0009653;GO:0035295;GO:0043085;GO:0007417;GO:1903900;GO:1903901;GO:0022612;GO:0060420;GO:0014866;GO:0007015;GO:0019079;GO:0003281;GO:0060429;GO:0045597;GO:0061114;GO:0045595;GO:0045892;GO:0045893;GO:0061113;GO:0008206;GO:0008202;GO:0051090;GO:0006082;GO:0051094;GO:0010628;GO:0045944;GO:0045860;GO:1903508;GO:0009991;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0021575;GO:0090304;GO:0002009;GO:0040007;GO:0071822;GO:0001938;GO:0040008;GO:0055007;GO:0048745;GO:0010467;GO:1902115;GO:1902117;GO:0021872;GO:0010468;GO:0009987;GO:0019752;GO:0042471;GO:0021587;GO:0048699;GO:0042472;GO:0007010;GO:0007399;GO:0060840;GO:0070858;GO:0001934;GO:0044087;GO:0044085;GO:0060849;GO:0016032;GO:0045214;GO:0001936;GO:0001935;GO:0060841;GO:0044089; small molecule metabolic process;small molecule biosynthetic process;regulation of metabolic process;endocardium development;morphogenesis of an endothelium;endothelium development;positive regulation of cytoskeleton organization;olfactory placode formation;regulation of cytoskeleton organization;otic vesicle formation;epithelial cell differentiation;otic vesicle morphogenesis;respiratory system development;regulation of protein kinase activity;heterocycle metabolic process;positive regulation of epithelial cell migration;positive regulation of phosphorylation;epithelial cell migration;response to external stimulus;protein metabolic process;positive regulation of organelle organization;lymphatic endothelial cell fate commitment;head development;muscle cell differentiation;telencephalon development;embryonic organ morphogenesis;cell differentiation in hindbrain;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;embryonic organ development;embryonic camera-type eye development;positive regulation of protein serine/threonine kinase activity;regulation of protein serine/threonine kinase activity;regulation of biological process;cardiac chamber development;cardiac chamber morphogenesis;positive regulation of transferase activity;cell morphogenesis;cardiac atrium morphogenesis;cardiac ventricle morphogenesis;cellular component organization or biogenesis;heterocycle biosynthetic process;circadian rhythm;lipid metabolic process;dentate gyrus development;pallium development;macromolecule modification;epithelial cell fate commitment;regulation of actin cytoskeleton organization;cerebellum development;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;steroid biosynthetic process;bile acid biosynthetic process;aorta morphogenesis;negative regulation of macromolecule biosynthetic process;hepatocyte cell migration;positive regulation of developmental growth;regulation of developmental growth;regulation of protein metabolic process;regulation of cellular component organization;hippocampus development;positive regulation of forebrain neuron differentiation;limbic system development;regulation of forebrain neuron differentiation;regulation of epithelial cell migration;positive regulation of growth;positive regulation of protein metabolic process;negative regulation of transcription from RNA polymerase II promoter;negative regulation of viral genome replication;regulation of cell development;animal organ development;hepatocyte differentiation;positive regulation of cell proliferation;muscle cell development;striated muscle cell development;cardiac myofibril assembly;ventricular cardiac myofibril assembly;cardiac cell development;cell proliferation;cardiac muscle tissue morphogenesis;atrial cardiac muscle tissue morphogenesis;regulation of striated muscle cell differentiation;eye development;urogenital system development;positive regulation of striated muscle cell differentiation;regulation of protein phosphorylation;cell cycle process;actomyosin structure organization;actin cytoskeleton organization;liver development;lens development in camera-type eye;lens morphogenesis in camera-type eye;endothelial cell differentiation;optic placode formation involved in camera-type eye formation;multicellular organism development;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;embryonic morphogenesis;protein phosphorylation;neural tube development;regulation of lipid metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of steroid metabolic process;eye morphogenesis;camera-type eye morphogenesis;embryonic camera-type eye morphogenesis;single-organism developmental process;multi-organism cellular process;single-organism cellular process;locomotion;positive regulation of cellular component movement;regulation of cellular component movement;positive regulation of endothelial cell migration;regulation of endothelial cell migration;positive regulation of locomotion;anatomical structure development;regulation of circadian rhythm;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of viral process;negative regulation of cellular process;positive regulation of cellular process;single-organism metabolic process;single-organism biosynthetic process;positive regulation of cell cycle;negative regulation of sequence-specific DNA binding transcription factor activity;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of molecular function;negative regulation of molecular function;cerebellar cortex morphogenesis;cerebellar cortex formation;cerebellar cortex development;glandular epithelial cell differentiation;epithelial cell development;columnar/cuboidal epithelial cell differentiation;regulation of phosphorylation;negative regulation of lipid biosynthetic process;regulation of RNA biosynthetic process;multi-organism process;stem cell population maintenance;endocardium morphogenesis;embryo development;response to nutrient levels;regulation of cyclin-dependent protein kinase activity;hepaticobiliary system development;metencephalon development;negative regulation of gene expression;nitrogen compound metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;blood vessel development;single-organism process;transcription from RNA polymerase II promoter;organ morphogenesis;regulation of developmental process;regulation of viral process;regulation of catalytic activity;regulation of biosynthetic process;tissue development;regulation of cellular process;cellular protein modification process;regulation of multicellular organismal process;cardiac atrium development;cardiac ventricle development;regulation of phosphorus metabolic process;carboxylic acid biosynthetic process;response to stimulus;cardiac septum development;regulation of transferase activity;positive regulation of nervous system development;regulation of nervous system development;regulation of cell motility;positive regulation of cell motility;camera-type eye development;positive regulation of phosphorus metabolic process;regulation of organelle organization;regulation of cell cycle process;regulation of cellular ketone metabolic process;regulation of transcription involved in cell fate commitment;negative regulation of metabolic process;regulation of cellular protein metabolic process;cell cycle;regulation of neurogenesis;positive regulation of multicellular organismal process;positive regulation of kinase activity;vasculature development;lymph vessel development;lymphangiogenesis;positive regulation of neurogenesis;regulation of protein modification process;central nervous system neuron differentiation;lens fiber cell morphogenesis;lens fiber cell differentiation;lens fiber cell development;regulation of locomotion;epithelium migration;tissue migration;positive regulation of sarcomere organization;regulation of viral genome replication;regulation of sarcomere organization;positive regulation of RNA biosynthetic process;system development;gland development;ventricular cardiac muscle cell development;respiratory tube development;lung development;ventricular cardiac muscle cell differentiation;ventricular cardiac muscle tissue morphogenesis;macromolecular complex subunit organization;skeletal muscle thin filament assembly;embryonic retina morphogenesis in camera-type eye;striated muscle tissue development;positive regulation of heart growth;morphogenesis of a branching structure;regulation of muscle cell differentiation;striated muscle cell differentiation;positive regulation of muscle cell differentiation;lymph vessel morphogenesis;embryonic eye morphogenesis;monocarboxylic acid biosynthetic process;nose development;ear development;neural precursor cell proliferation;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;actin filament-based process;morphogenesis of a branching epithelium;regulation of organ growth;positive regulation of organ growth;cardiocyte differentiation;cell morphogenesis involved in differentiation;neurogenesis;lipid biosynthetic process;organelle organization;primary metabolic process;cellular metabolic process;muscle tissue development;symbiosis, encompassing mutualism through parasitism;regulation of phosphate metabolic process;developmental growth;positive regulation of epithelial cell proliferation;dorsal spinal cord development;cell development;spinal cord development;circulatory system development;cardiovascular system development;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular developmental process;kidney development;rhythmic process;viral life cycle;blood vessel morphogenesis;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;heart morphogenesis;olfactory placode morphogenesis;olfactory placode development;oxoacid metabolic process;ectodermal placode morphogenesis;ectodermal placode development;single-multicellular organism process;organic acid biosynthetic process;cerebellar granular layer formation;ectodermal placode formation;cerebellar granular layer development;cerebellar granular layer morphogenesis;cellular component assembly;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;localization of cell;cerebellar granule cell differentiation;nucleic acid-templated transcription;endothelial cell migration;cardiac muscle tissue development;regulation of kinase activity;negative regulation of cell proliferation;positive regulation of cyclin-dependent protein kinase activity;cell migration;muscle organ morphogenesis;anatomical structure formation involved in morphogenesis;regulation of bile acid metabolic process;negative regulation of bile acid metabolic process;regulation of symbiosis, encompassing mutualism through parasitism;regulation of multi-organism process;negative regulation of multi-organism process;regulation of steroid biosynthetic process;nucleobase-containing compound biosynthetic process;neuronal stem cell population maintenance;cellular nitrogen compound biosynthetic process;brain development;sensory organ development;hepatocyte proliferation;positive regulation of protein modification process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;RNA biosynthetic process;cell differentiation;cellular component assembly involved in morphogenesis;retina development in camera-type eye;retina morphogenesis in camera-type eye;atrial cardiac muscle tissue development;muscle structure development;cardiac muscle cell development;nucleobase-containing compound metabolic process;cell fate determination;regulation of neural precursor cell proliferation;positive regulation of cellular protein metabolic process;chordate embryonic development;positive regulation of neural precursor cell proliferation;developmental process;multicellular organismal process;regulation of actin filament-based process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;endocardium formation;renal system development;regulation of localization;liver morphogenesis;inner ear development;regulation of epithelial cell proliferation;epithelial cell proliferation involved in liver morphogenesis;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;epithelial cell proliferation;heart development;regulation of lipid biosynthetic process;macromolecule metabolic process;positive regulation of phosphate metabolic process;cellular component morphogenesis;organic substance metabolic process;tissue morphogenesis;sensory organ morphogenesis;positive regulation of cell migration;regulation of cell migration;myofibril assembly;aorta development;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;negative regulation of steroid metabolic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;organelle assembly;localization;cellular ketone metabolic process;cell cycle checkpoint;regulation of cell cycle;regulation of cyclin-dependent protein serine/threonine kinase activity;single-organism organelle organization;forebrain development;hindbrain development;artery morphogenesis;venous blood vessel morphogenesis;regulation of primary metabolic process;organ growth;optic placode formation;muscle organ development;regulation of bile acid biosynthetic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;otic placode formation;positive regulation of cell cycle process;interspecies interaction between organisms;negative regulation of lipid metabolic process;negative regulation of steroid biosynthetic process;pancreas development;regulation of macromolecule metabolic process;forebrain neuron differentiation;monocarboxylic acid metabolic process;embryonic camera-type eye formation;acinar cell differentiation;cell motility;heart growth;aromatic compound biosynthetic process;cardiac septum morphogenesis;muscle tissue morphogenesis;aorta smooth muscle tissue morphogenesis;ventricular cardiac muscle tissue development;organic substance biosynthetic process;neuron differentiation;cellular component organization;otic vesicle development;lymphatic endothelial cell differentiation;biological regulation;regulation of molecular function;endothelial cell fate commitment;positive regulation of cellular component organization;maintenance of cell number;protein modification process;biological_process;metabolic process;ventricular septum morphogenesis;cell fate commitment;positive regulation of cell cycle checkpoint;positive regulation of cyclin-dependent protein serine/threonine kinase activity;regulation of cell cycle checkpoint;phosphorylation;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;cellular macromolecule biosynthetic process;ameboidal-type cell migration;anatomical structure morphogenesis;tube development;positive regulation of catalytic activity;central nervous system development;regulation of viral life cycle;negative regulation of viral life cycle;gland morphogenesis;regulation of heart growth;skeletal myofibril assembly;actin filament organization;viral genome replication;ventricular septum development;epithelium development;positive regulation of cell differentiation;branching involved in pancreas morphogenesis;regulation of cell differentiation;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;pancreas morphogenesis;bile acid metabolic process;steroid metabolic process;regulation of sequence-specific DNA binding transcription factor activity;organic acid metabolic process;positive regulation of developmental process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of protein kinase activity;positive regulation of nucleic acid-templated transcription;response to extracellular stimulus;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;hindbrain morphogenesis;nucleic acid metabolic process;morphogenesis of an epithelium;growth;protein complex subunit organization;positive regulation of endothelial cell proliferation;regulation of growth;cardiac muscle cell differentiation;smooth muscle tissue development;gene expression;regulation of organelle assembly;positive regulation of organelle assembly;forebrain generation of neurons;regulation of gene expression;cellular process;carboxylic acid metabolic process;ear morphogenesis;cerebellum morphogenesis;generation of neurons;inner ear morphogenesis;cytoskeleton organization;nervous system development;artery development;negative regulation of bile acid biosynthetic process;positive regulation of protein phosphorylation;regulation of cellular component biogenesis;cellular component biogenesis;regulation of transcription involved in lymphatic endothelial cell fate commitment;viral process;sarcomere organization;regulation of endothelial cell proliferation;endothelial cell proliferation;venous blood vessel development;positive regulation of cellular component biogenesis; 4;5;3;4;6;6;6;5;6;4;6;6;5;7;4;4;7;6;3;4;5;6;4;5;4;5;5;3;4;4;4;5;9;8;2;4;4;6;5;5;5;2;5;3;4;4;4;5;6;5;4;5;5;5;6;6;6;5;5;4;4;5;4;4;7;5;7;4;3;5;7;6;5;4;6;4;5;6;6;7;5;3;6;6;6;5;5;6;7;4;6;5;5;4;4;7;5;4;6;6;4;7;4;5;5;6;6;7;6;3;3;3;2;4;4;5;5;3;3;3;5;4;4;4;3;3;3;4;4;5;7;6;4;4;4;4;4;8;5;7;7;5;6;2;4;5;5;5;5;5;4;5;3;5;4;4;2;7;4;3;4;4;4;4;3;6;3;5;5;5;6;2;4;5;4;5;4;4;6;5;5;5;5;6;3;5;4;6;3;7;5;4;4;5;6;6;5;5;6;3;5;4;5;6;5;6;4;4;7;4;4;7;6;4;7;5;6;5;4;5;6;5;4;6;7;5;5;4;5;5;4;5;4;4;5;5;6;5;4;3;3;5;4;6;3;5;4;4;5;5;5;5;4;4;4;2;5;4;5;2;2;4;5;5;5;5;4;4;3;5;4;4;4;4;4;4;4;3;5;7;7;5;6;4;6;4;5;3;5;5;4;3;3;6;5;5;5;4;4;6;6;6;7;6;5;4;6;5;4;4;5;6;4;6;4;5;5;5;7;5;2;2;4;4;7;7;4;5;3;6;4;5;5;5;5;5;4;4;5;4;6;4;3;4;5;5;5;5;6;6;3;5;5;4;4;4;5;2;4;5;4;6;4;4;4;5;5;4;4;5;5;6;4;4;5;5;3;4;6;4;4;6;7;4;9;3;5;5;4;5;6;6;4;6;3;5;5;2;3;7;4;3;5;1;2;5;5;6;5;6;6;4;4;6;5;5;3;4;5;5;5;5;5;5;6;6;5;5;5;4;6;4;6;6;5;5;5;4;4;3;5;7;8;7;4;5;5;5;4;4;4;4;5;5;2;5;6;3;6;6;5;4;4;5;5;2;6;6;4;7;5;5;5;5;6;7;3;3;7;4;6;6;5;5;3; GO:0044424;GO:0044464;GO:0043231;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0005623;GO:0005622;GO:0005575; intracellular part;cell part;intracellular membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;cell;intracellular;cellular_component; 3;2;4;3;3;2;4;5;2;3;1; GO:0001067;GO:0001227;GO:0044212;GO:0005488;GO:0000976;GO:0000975;GO:0043565;GO:0005515;GO:0050693;GO:0001047;GO:0001046;GO:0003700;GO:0003705;GO:1901363;GO:0019904;GO:0003674;GO:0003676;GO:0003677;GO:0005102;GO:0097159;GO:1990837;GO:0001071;GO:0001078;GO:0003714;GO:0003712;GO:0000989;GO:0000988;GO:0000982;GO:0000981;GO:0050692;GO:0016922;GO:0003690; regulatory region nucleic acid binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;transcription regulatory region DNA binding;binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;sequence-specific DNA binding;protein binding;LBD domain binding;core promoter binding;core promoter sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding;transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;heterocyclic compound binding;protein domain specific binding;molecular_function;nucleic acid binding;DNA binding;receptor binding;organic cyclic compound binding;sequence-specific double-stranded DNA binding;nucleic acid binding transcription factor activity;transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;transcription corepressor activity;transcription cofactor activity;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;DBD domain binding;ligand-dependent nuclear receptor binding;double-stranded DNA binding; 5;5;7;2;8;6;6;3;5;8;9;3;5;3;4;1;4;5;4;3;7;2;6;5;4;3;2;5;4;5;5;6; K20211 IPR009057;IPR023082;IPR007738; Homeobox domain-like;Homeo-prospero domain;Prospero homeobox protein 1; nucleus Hs21359846 1538.0 K [K] Transcription; Q8IVF6 Ankyrin repeat domain-containing protein 18A OS=Homo sapiens OX=9606 GN=ANKRD18A PE=2 SV=3 - [AN18A_HUMAN] 1.103 1.048 0.882 1.126 1.048 1.087 1.052480916 0.769094989 1.074427481 0.821678458 0.841603053 0.169246603 1.03721374 0.451978246 IPR002110;IPR021885;IPR020683; Ankyrin repeat;Protein of unknown function DUF3496;Ankyrin repeat-containing domain; cytosol, nucleus Hs22045770_1 614.0 R [R] General function prediction only; P28290 Protein ITPRID2 OS=Homo sapiens OX=9606 GN=ITPRID2 PE=1 SV=3 - [ITPI2_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0016020;GO:0005886;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;cell periphery;membrane-bounded organelle;organelle;cytoplasm;nucleus;membrane;plasma membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;3;2;4;5;2;3;4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0003779;GO:0032403;GO:0051015;GO:0008092;GO:0005515;GO:0044877; molecular_function;binding;actin binding;protein complex binding;actin filament binding;cytoskeletal protein binding;protein binding;macromolecular complex binding; 1;2;5;4;5;4;3;3; IPR029326;IPR029325;IPR026648; Sperm-specific antigen 2, C-terminal;IP3R-interacting domain;Sperm-specific antigen 2; nucleus Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3 - [ARAP1_HUMAN] 0.918 0.728 1.503 1.028 0.702 1.732 1.260989011 nan 1.464387464 nan 2.06456044 nan 2.467236467 nan GO:0019222;GO:0048583;GO:0060491;GO:0007165;GO:0031344;GO:0071840;GO:0031346;GO:0032231;GO:0032232;GO:0010604;GO:0051497;GO:0048869;GO:0051494;GO:0051493;GO:0051492;GO:0051491;GO:0044093;GO:0048518;GO:0048519;GO:0060255;GO:0008360;GO:0044700;GO:0044089;GO:0010639;GO:0001919;GO:0046847;GO:0022604;GO:0022607;GO:0009893;GO:0022603;GO:0006928;GO:0035556;GO:0050789;GO:0010646;GO:0043547;GO:0044260;GO:0016043;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0043149;GO:0051130;GO:0050793;GO:0050790;GO:0051716;GO:0050794;GO:0008150;GO:0008152;GO:0032956;GO:1902531;GO:0051336;GO:0050896;GO:0009966;GO:0061572;GO:0033043;GO:0051129;GO:0051128;GO:0023056;GO:0023052;GO:0023051;GO:0009653;GO:0043087;GO:0044699;GO:0030030;GO:0032502;GO:0051489;GO:0032970;GO:0051017;GO:0090527;GO:0032879;GO:0007049;GO:0043170;GO:0030038;GO:0048856;GO:0031032;GO:0051056;GO:0043933;GO:0030031;GO:0031325;GO:0031323;GO:0030036;GO:0030037;GO:0022402;GO:0001881;GO:0071822;GO:0031532;GO:0071704;GO:0001921;GO:0009987;GO:0030029;GO:0044767;GO:0044763;GO:0007154;GO:0007264;GO:0051179;GO:0000902;GO:0006996;GO:0007015;GO:0051270;GO:0007010;GO:0051345;GO:0044237;GO:0044087;GO:1902589;GO:0044085;GO:0032989;GO:0043112;GO:0048523;GO:0048522; regulation of metabolic process;regulation of response to stimulus;regulation of cell projection assembly;signal transduction;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;regulation of actin filament bundle assembly;negative regulation of actin filament bundle assembly;positive regulation of macromolecule metabolic process;negative regulation of stress fiber assembly;cellular developmental process;negative regulation of cytoskeleton organization;regulation of cytoskeleton organization;regulation of stress fiber assembly;positive regulation of filopodium assembly;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of cell shape;single organism signaling;positive regulation of cellular component biogenesis;negative regulation of organelle organization;regulation of receptor recycling;filopodium assembly;regulation of cell morphogenesis;cellular component assembly;positive regulation of metabolic process;regulation of anatomical structure morphogenesis;movement of cell or subcellular component;intracellular signal transduction;regulation of biological process;regulation of cell communication;positive regulation of GTPase activity;cellular macromolecule metabolic process;cellular component organization;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;stress fiber assembly;positive regulation of cellular component organization;regulation of developmental process;regulation of catalytic activity;cellular response to stimulus;regulation of cellular process;biological_process;metabolic process;regulation of actin cytoskeleton organization;regulation of intracellular signal transduction;regulation of hydrolase activity;response to stimulus;regulation of signal transduction;actin filament bundle organization;regulation of organelle organization;negative regulation of cellular component organization;regulation of cellular component organization;positive regulation of signaling;signaling;regulation of signaling;anatomical structure morphogenesis;regulation of GTPase activity;single-organism process;cell projection organization;developmental process;regulation of filopodium assembly;regulation of actin filament-based process;actin filament bundle assembly;actin filament reorganization;regulation of localization;cell cycle;macromolecule metabolic process;contractile actin filament bundle assembly;anatomical structure development;actomyosin structure organization;regulation of small GTPase mediated signal transduction;macromolecular complex subunit organization;cell projection assembly;positive regulation of cellular metabolic process;regulation of cellular metabolic process;actin cytoskeleton organization;actin filament reorganization involved in cell cycle;cell cycle process;receptor recycling;protein complex subunit organization;actin cytoskeleton reorganization;organic substance metabolic process;positive regulation of receptor recycling;cellular process;actin filament-based process;single-organism developmental process;single-organism cellular process;cell communication;small GTPase mediated signal transduction;localization;cell morphogenesis;organelle organization;actin filament organization;regulation of cellular component movement;cytoskeleton organization;positive regulation of hydrolase activity;cellular metabolic process;regulation of cellular component biogenesis;single-organism organelle organization;cellular component biogenesis;cellular component morphogenesis;receptor metabolic process;negative regulation of cellular process;positive regulation of cellular process; 3;3;4;4;5;2;5;4;5;4;6;4;6;6;5;4;4;2;2;4;4;3;3;5;4;6;5;4;3;4;4;5;2;4;7;4;3;2;5;3;3;7;4;3;4;3;3;1;2;5;5;5;2;4;7;5;4;4;3;2;3;3;6;2;4;2;5;4;5;7;3;4;4;6;3;6;6;4;5;4;4;5;5;4;4;5;6;3;4;2;4;3;3;4;6;2;5;4;6;4;5;6;3;3;4;3;4;5;3;3; GO:0031984;GO:0005795;GO:0005794;GO:0098588;GO:0043231;GO:0005829;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044431;GO:0012505;GO:0031982;GO:0000139;GO:0044446;GO:0044444;GO:0097708;GO:0005737;GO:0031090;GO:0031410;GO:0032580;GO:0044464;GO:0005623;GO:0031985;GO:0071944;GO:0016020;GO:0043226;GO:0005886;GO:0005802;GO:0005575;GO:0098791; organelle subcompartment;Golgi stack;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;cytosol;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;Golgi apparatus part;endomembrane system;vesicle;Golgi membrane;intracellular organelle part;cytoplasmic part;intracellular vesicle;cytoplasm;organelle membrane;cytoplasmic vesicle;Golgi cisterna membrane;cell part;cell;Golgi cisterna;cell periphery;membrane;organelle;plasma membrane;trans-Golgi network;cellular_component;Golgi subcompartment; 4;5;4;4;4;5;3;2;3;3;3;4;3;4;5;3;4;4;4;3;5;6;2;2;6;3;2;2;3;5;1;5; GO:0098772;GO:0005547;GO:0046872;GO:0005096;GO:0030695;GO:0003674;GO:0005488;GO:0043168;GO:0035091;GO:0005543;GO:1901981;GO:0043169;GO:0043167;GO:0008289;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;phosphatidylinositol-3,4,5-trisphosphate binding;metal ion binding;GTPase activator activity;GTPase regulator activity;molecular_function;binding;anion binding;phosphatidylinositol binding;phospholipid binding;phosphatidylinositol phosphate binding;cation binding;ion binding;lipid binding;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;7;5;5;5;1;2;4;5;4;6;4;3;3;4;4;3; K18439 map04144; Endocytosis; IPR001164;IPR000159;IPR013761;IPR000198;IPR008936;IPR001849;IPR011993;IPR001660; Arf GTPase activating protein;Ras-associating (RA) domain;Sterile alpha motif/pointed domain;Rho GTPase-activating protein domain;Rho GTPase activation protein;Pleckstrin homology domain;PH domain-like;Sterile alpha motif domain; cytosol, nucleus Hs21264597 2490.0 TZ [T] Signal transduction mechanisms;[Z] Cytoskeleton; Q92621 Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3 - [NU205_HUMAN] 0.878 0.914 1.431 0.812 0.824 0.825 0.960612691 0.835104791 0.985436893 0.839582603 1.565645514 0.435169643 1.001213592 0.924985939 GO:0051169;GO:0006997;GO:0019221;GO:0019222;GO:0051049;GO:0034605;GO:0043412;GO:0048583;GO:0061024;GO:0008104;GO:0007165;GO:0007166;GO:0044744;GO:1901362;GO:1901360;GO:0071705;GO:0051716;GO:0016925;GO:0010605;GO:0070727;GO:0071840;GO:0010256;GO:0071310;GO:0018193;GO:0044419;GO:0032446;GO:0016458;GO:0019058;GO:0051817;GO:0048519;GO:0051704;GO:0019054;GO:0034470;GO:0060255;GO:0051292;GO:0045184;GO:0007077;GO:0051701;GO:0010033;GO:0046483;GO:0044700;GO:0019538;GO:0018205;GO:0033554;GO:0019438;GO:0044281;GO:0022607;GO:0009892;GO:0019080;GO:0044068;GO:0019083;GO:0006807;GO:0044033;GO:0034660;GO:0051028;GO:0000278;GO:1901576;GO:0044260;GO:0008645;GO:0006886;GO:0016043;GO:0008643;GO:0065007;GO:0007049;GO:0065008;GO:0018130;GO:0034613;GO:0034097;GO:0006810;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0009266;GO:0034654;GO:0051236;GO:0051234;GO:0046931;GO:0016070;GO:0050658;GO:0044271;GO:0046907;GO:0071345;GO:0050896;GO:0080135;GO:0009058;GO:0044764;GO:0044802;GO:0015931;GO:0032774;GO:0070271;GO:0070647;GO:0017038;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0006139;GO:0051081;GO:0051179;GO:0008033;GO:0051170;GO:0009628;GO:0072594;GO:0043687;GO:0009987;GO:0006725;GO:1902582;GO:0009408;GO:0032879;GO:0055085;GO:0000059;GO:0030397;GO:0033036;GO:1900034;GO:0010629;GO:0043170;GO:0033365;GO:0080134;GO:0034504;GO:0043933;GO:0019048;GO:1903047;GO:0050657;GO:0090304;GO:0010827;GO:0065003;GO:0022402;GO:0006998;GO:0034622;GO:0005975;GO:0071822;GO:0006399;GO:1902593;GO:0050789;GO:0015758;GO:0071704;GO:0010467;GO:0071702;GO:0006403;GO:0010468;GO:0015749;GO:0044267;GO:0006606;GO:0006461;GO:0006913;GO:0006464;GO:0044765;GO:0009059;GO:0044763;GO:0031047;GO:0051649;GO:0007154;GO:0006605;GO:0043623;GO:0044003;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0044237;GO:0006999;GO:0044085;GO:0016032;GO:0015031;GO:0044403;GO:1902580;GO:0022411;GO:0035821;GO:0006396; nuclear transport;nucleus organization;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of transport;cellular response to heat;macromolecule modification;regulation of response to stimulus;membrane organization;protein localization;signal transduction;cell surface receptor signaling pathway;protein targeting to nucleus;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;nitrogen compound transport;cellular response to stimulus;protein sumoylation;negative regulation of macromolecule metabolic process;cellular macromolecule localization;cellular component organization or biogenesis;endomembrane system organization;cellular response to organic substance;peptidyl-amino acid modification;interspecies interaction between organisms;protein modification by small protein conjugation;gene silencing;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of biological process;multi-organism process;modulation by virus of host process;ncRNA processing;regulation of macromolecule metabolic process;nuclear pore complex assembly;establishment of protein localization;mitotic nuclear envelope disassembly;interaction with host;response to organic substance;heterocycle metabolic process;single organism signaling;protein metabolic process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;small molecule metabolic process;cellular component assembly;negative regulation of metabolic process;viral gene expression;modulation by symbiont of host cellular process;viral transcription;nitrogen compound metabolic process;multi-organism metabolic process;ncRNA metabolic process;mRNA transport;mitotic cell cycle;organic substance biosynthetic process;cellular macromolecule metabolic process;hexose transport;intracellular protein transport;cellular component organization;carbohydrate transport;biological regulation;cell cycle;regulation of biological quality;heterocycle biosynthetic process;cellular protein localization;response to cytokine;transport;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;response to temperature stimulus;nucleobase-containing compound biosynthetic process;establishment of RNA localization;establishment of localization;pore complex assembly;RNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;intracellular transport;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;biosynthetic process;multi-organism cellular process;single-organism membrane organization;nucleobase-containing compound transport;RNA biosynthetic process;protein complex biogenesis;protein modification by small protein conjugation or removal;protein import;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;nucleobase-containing compound metabolic process;nuclear envelope disassembly;localization;tRNA processing;nuclear import;response to abiotic stimulus;establishment of protein localization to organelle;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;single-organism intracellular transport;response to heat;regulation of localization;transmembrane transport;protein import into nucleus, docking;membrane disassembly;macromolecule localization;regulation of cellular response to heat;negative regulation of gene expression;macromolecule metabolic process;protein localization to organelle;regulation of response to stress;protein localization to nucleus;macromolecular complex subunit organization;modulation by virus of host morphology or physiology;mitotic cell cycle process;nucleic acid transport;nucleic acid metabolic process;regulation of glucose transport;macromolecular complex assembly;cell cycle process;nuclear envelope organization;cellular macromolecular complex assembly;carbohydrate metabolic process;protein complex subunit organization;tRNA metabolic process;single-organism nuclear import;regulation of biological process;glucose transport;organic substance metabolic process;gene expression;organic substance transport;RNA localization;regulation of gene expression;monosaccharide transport;cellular protein metabolic process;protein import into nucleus;protein complex assembly;nucleocytoplasmic transport;cellular protein modification process;single-organism transport;macromolecule biosynthetic process;single-organism cellular process;gene silencing by RNA;establishment of localization in cell;cell communication;protein targeting;cellular protein complex assembly;modification by symbiont of host morphology or physiology;single-organism localization;cellular localization;organelle organization;primary metabolic process;cellular metabolic process;nuclear pore organization;cellular component biogenesis;viral process;protein transport;symbiosis, encompassing mutualism through parasitism;single-organism cellular localization;cellular component disassembly;modification of morphology or physiology of other organism;RNA processing; 6;5;6;3;4;5;5;3;4;4;4;5;5;5;4;5;3;9;4;4;2;4;5;7;3;8;4;5;4;2;2;5;7;4;7;4;6;4;4;4;3;4;8;4;5;4;4;3;4;4;5;3;3;6;6;5;4;4;7;6;3;5;2;4;3;5;5;5;4;3;3;3;5;1;2;4;5;4;3;6;5;5;5;5;6;2;4;3;3;4;6;6;4;7;5;4;4;2;4;3;2;4;6;2;8;8;3;5;7;2;4;5;4;3;4;6;5;3;5;5;4;6;4;7;4;5;5;7;5;5;5;4;5;6;4;5;7;6;2;8;3;5;5;4;5;6;5;5;5;7;6;4;5;3;5;4;4;6;6;5;3;3;4;3;3;6;3;4;5;4;4;4;3;6; GO:0031974;GO:0031975;GO:0031981;GO:0016020;GO:0031965;GO:0031967;GO:0043234;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0034399;GO:0012505;GO:0044446;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0044611;GO:0044464;GO:0005623;GO:0005643;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;nuclear lumen;membrane;nuclear membrane;organelle envelope;protein complex;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;nuclear periphery;endomembrane system;intracellular organelle part;cytoplasm;organelle membrane;nucleus;nuclear envelope;nuclear pore inner ring;cell part;cell;nuclear pore;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;5;2;4;4;3;4;3;4;3;2;3;3;3;2;5;5;3;3;4;3;5;4;4;2;2;5;2;1;4; GO:0005198;GO:0003674;GO:0017056; structural molecule activity;molecular_function;structural constituent of nuclear pore; 2;1;3; K14310 map03013; RNA transport; IPR011989;IPR021827; Armadillo-like helical;Nucleoporin Nup186/Nup192/Nup205; plasma membrane Hs20540895 3792.0 S [S] Function unknown; Q9P109 Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 OS=Homo sapiens OX=9606 GN=GCNT4 PE=2 SV=1 - [GCNT4_HUMAN] 2.015 0.572 0.713 1.407 0.645 0.605 3.522727273 0.005026047 2.181395349 0.00757176 1.246503497 0.418899192 0.937984496 0.618996669 GO:1901360;GO:0042445;GO:0044710;GO:0001822;GO:0048513;GO:0060993;GO:0051704;GO:0007610;GO:0051705;GO:0006575;GO:1901564;GO:0044707;GO:0019538;GO:0006807;GO:0044267;GO:0044260;GO:0065007;GO:0065008;GO:0009887;GO:0016266;GO:0009888;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0002118;GO:0043413;GO:1901615;GO:0044249;GO:0042403;GO:0034645;GO:0009653;GO:0006493;GO:0044699;GO:0032502;GO:0032501;GO:0043687;GO:0009987;GO:0006725;GO:0048872;GO:0001655;GO:0018958;GO:0072001;GO:1901137;GO:1901135;GO:0043170;GO:0048731;GO:0042592;GO:0002121;GO:0009100;GO:0009101;GO:0006486;GO:0007275;GO:0071704;GO:0048729;GO:1901576;GO:0070085;GO:0006464;GO:0010817;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0044238;GO:0005975;GO:0048856;GO:0044237; organic cyclic compound metabolic process;hormone metabolic process;single-organism metabolic process;kidney development;animal organ development;kidney morphogenesis;multi-organism process;behavior;multi-organism behavior;cellular modified amino acid metabolic process;organonitrogen compound metabolic process;single-multicellular organism process;protein metabolic process;nitrogen compound metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;regulation of biological quality;organ morphogenesis;O-glycan processing;tissue development;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;aggressive behavior;macromolecule glycosylation;organic hydroxy compound metabolic process;cellular biosynthetic process;thyroid hormone metabolic process;cellular macromolecule biosynthetic process;anatomical structure morphogenesis;protein O-linked glycosylation;single-organism process;developmental process;multicellular organismal process;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;homeostasis of number of cells;urogenital system development;phenol-containing compound metabolic process;renal system development;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;system development;homeostatic process;inter-male aggressive behavior;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;multicellular organism development;organic substance metabolic process;tissue morphogenesis;organic substance biosynthetic process;glycosylation;cellular protein modification process;regulation of hormone levels;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;primary metabolic process;carbohydrate metabolic process;anatomical structure development;cellular metabolic process; 4;3;3;4;4;5;2;2;3;4;4;3;4;3;5;4;2;3;4;6;4;5;5;1;2;4;4;6;4;4;4;5;3;5;2;2;2;7;2;4;5;5;5;5;5;4;4;4;4;5;5;6;4;4;3;4;4;5;6;4;3;3;5;3;3;4;3;3; GO:0016021;GO:0016020;GO:0005794;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0044431;GO:0031224;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005575; integral component of membrane;membrane;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;Golgi apparatus part;intrinsic component of membrane;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;cell part;cell;cellular_component; 4;2;4;4;4;3;2;2;3;3;3;2;4;3;3;5;3;4;4;3;2;2;1; GO:0008109;GO:0008375;GO:0016740;GO:0016757;GO:0003674;GO:0003824;GO:0016758;GO:0003829;GO:0008194; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;acetylglucosaminyltransferase activity;transferase activity;transferase activity, transferring glycosyl groups;molecular_function;catalytic activity;transferase activity, transferring hexosyl groups;beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;UDP-glycosyltransferase activity; 7;6;3;4;1;2;5;7;5; K09663 map00512;map01100; Mucin type O-Glycan biosynthesis;Metabolic pathways; IPR003406; Glycosyl transferase, family 14; Golgi apparatus Hs7706127 940.0 G [G] Carbohydrate transport and metabolism; Q8ND82 Zinc finger protein 280C OS=Homo sapiens OX=9606 GN=ZNF280C PE=1 SV=1 - [Z280C_HUMAN] 0.697 0.634 2.329 0.86 0.488 0.624 1.099369085 nan 1.762295082 nan 3.673501577 nan 1.278688525 nan GO:0080090;GO:0019222;GO:0048468;GO:0032989;GO:1901362;GO:1901360;GO:0010605;GO:0042330;GO:0048869;GO:0048519;GO:0006935;GO:0060255;GO:2001141;GO:0097485;GO:0046483;GO:0044707;GO:0019438;GO:0009892;GO:0009890;GO:0006928;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:0009605;GO:1901576;GO:0000904;GO:0000902;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0006366;GO:0018130;GO:0061564;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044767;GO:0044271;GO:0050896;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0030154;GO:0044249;GO:0034641;GO:0034645;GO:0007411;GO:0009653;GO:0044699;GO:0006139;GO:0000122;GO:0030030;GO:0031175;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0007409;GO:0048858;GO:0051253;GO:0051252;GO:0010629;GO:0048731;GO:0048812;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0007275;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0048666;GO:0048667;GO:0045934;GO:0030182;GO:0019219;GO:1902679;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0042221;GO:0022008;GO:0040011;GO:0044238;GO:0048699;GO:0032990;GO:0007399;GO:0048856;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;cell development;cellular component morphogenesis;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;taxis;cellular developmental process;negative regulation of biological process;chemotaxis;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;neuron projection guidance;heterocycle metabolic process;single-multicellular organism process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;movement of cell or subcellular component;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;response to external stimulus;organic substance biosynthetic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;transcription from RNA polymerase II promoter;heterocycle biosynthetic process;axon development;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;single-organism developmental process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;cell differentiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;axon guidance;anatomical structure morphogenesis;single-organism process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;cell projection organization;neuron projection development;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;axonogenesis;cell projection morphogenesis;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;system development;neuron projection morphogenesis;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organism development;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;negative regulation of nucleobase-containing compound metabolic process;neuron differentiation;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;response to chemical;neurogenesis;locomotion;primary metabolic process;generation of neurons;cell part morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;negative regulation of cellular process; 4;3;4;4;5;4;4;3;4;2;4;4;6;5;4;3;5;3;4;4;3;4;2;7;3;4;5;5;4;3;2;2;7;5;6;4;3;1;2;5;5;3;5;2;6;5;6;5;6;5;4;4;5;6;3;2;4;7;4;5;2;2;2;4;7;7;6;7;5;5;5;5;4;6;5;5;4;4;5;4;6;6;3;5;7;5;5;6;5;6;5;6;3;5;3;4;4;3;6;2;3;7;5;5;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:0001071;GO:1901363;GO:0046872;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000981;GO:0043169;GO:0097159;GO:0043167;GO:0001227;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;metal ion binding;molecular_function;binding;nucleic acid binding;DNA binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;cation binding;organic cyclic compound binding;ion binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;transcription factor activity, sequence-specific DNA binding; 2;3;5;1;2;4;5;4;4;3;3;5;3; IPR013087;IPR025243; Zinc finger C2H2-type;Domain of unknown function DUF4195; nucleus Hs8923097 593.0 R [R] General function prediction only; P00734 Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 SV=2 - [THRB_HUMAN] 1.013 1.018 1.011 1 1.037 1.093 0.995088409 0.116826338 0.964320154 0.796577003 0.993123772 0.000758149 1.054001929 2.35E-11 GO:0007599;GO:0051049;GO:0007597;GO:0007596;GO:0098771;GO:0019220;GO:0051716;GO:0018214;GO:0048585;GO:0010543;GO:0048583;GO:0008360;GO:0032845;GO:0042325;GO:0042327;GO:0009605;GO:0019538;GO:0017187;GO:0009892;GO:0009893;GO:0009891;GO:0035556;GO:0050789;GO:0006888;GO:0000902;GO:0097553;GO:2000379;GO:1903649;GO:2000377;GO:0043412;GO:0002526;GO:0010557;GO:0010556;GO:0009967;GO:0051128;GO:0010001;GO:0060284;GO:0045745;GO:0008284;GO:0050878;GO:0008283;GO:0006875;GO:0006874;GO:0043687;GO:0006873;GO:0001558;GO:0044259;GO:0044253;GO:0072511;GO:0050900;GO:0045927;GO:0060341;GO:0042592;GO:0061041;GO:0061045;GO:0007275;GO:0006468;GO:0006464;GO:0006465;GO:0010959;GO:0044765;GO:0044763;GO:0040011;GO:0051279;GO:0048856;GO:0006796;GO:2000021;GO:2000026;GO:0006793;GO:0014854;GO:0048523;GO:0048522;GO:0007165;GO:0007166;GO:0044710;GO:0044711;GO:0016310;GO:0010524;GO:0010522;GO:0051050;GO:1902656;GO:0018200;GO:0050820;GO:0006807;GO:0044267;GO:0009653;GO:0044260;GO:0007186;GO:0050793;GO:0009889;GO:0050794;GO:0051239;GO:0051238;GO:0051235;GO:0051234;GO:0044767;GO:0050896;GO:0010714;GO:0010712;GO:0051961;GO:0051960;GO:0006518;GO:0010562;GO:0032102;GO:0032103;GO:0032101;GO:0032964;GO:0032965;GO:0032967;GO:0032963;GO:0044699;GO:0050767;GO:0051248;GO:0090280;GO:0051240;GO:0051241;GO:0051246;GO:0051247;GO:0050768;GO:0031399;GO:1903034;GO:1903035;GO:1903036;GO:0072593;GO:0043270;GO:0014068;GO:0014065;GO:0014066;GO:0070838;GO:1904064;GO:1904062;GO:0048731;GO:0050865;GO:0050866;GO:0060401;GO:0060402;GO:0055065;GO:0022008;GO:0009628;GO:0051928;GO:0051924;GO:0044237;GO:0044236;GO:0032388;GO:0019222;GO:0032386;GO:0048584;GO:0048468;GO:0032846;GO:0032844;GO:0071840;GO:0009966;GO:0048869;GO:0051208;GO:0051209;GO:0010721;GO:0048518;GO:0048519;GO:0042127;GO:0044700;GO:0071214;GO:1901564;GO:0016192;GO:0044707;GO:0002376;GO:0070509;GO:0022604;GO:0022603;GO:0071260;GO:0006928;GO:0051674;GO:0043170;GO:0014014;GO:0014013;GO:1900046;GO:1900047;GO:1904427;GO:0016477;GO:1900048;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:0048708;GO:0006952;GO:0006950;GO:0050817;GO:0006954;GO:1902533;GO:1902531;GO:0050818;GO:0050819;GO:0048017;GO:0046907;GO:0006953;GO:0080134;GO:0031401;GO:0001775;GO:0030154;GO:0018193;GO:0048015;GO:0051917;GO:0032270;GO:0006508;GO:0051918;GO:0032502;GO:0032501;GO:0009987;GO:0016485;GO:0032879;GO:0016482;GO:0051604;GO:0043269;GO:0032989;GO:0071704;GO:0051174;GO:0034220;GO:0009058;GO:0009059;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0051480;GO:1902582;GO:0080090;GO:0051282;GO:0051283;GO:0051281;GO:0008277;GO:0055074;GO:0034764;GO:0034765;GO:0034767;GO:0034762;GO:0010605;GO:0010604;GO:0009611;GO:0009612;GO:0019725;GO:0060255;GO:0030162;GO:0090279;GO:0030168;GO:0048870;GO:0007200;GO:0070588;GO:0007204;GO:0048878;GO:0030193;GO:0030195;GO:0030194;GO:0048712;GO:0048710;GO:1903651;GO:1901576;GO:0016049;GO:0045937;GO:0016043;GO:0010544;GO:0065007;GO:0098662;GO:0098660;GO:0065008;GO:0042063;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0042730;GO:0030307;GO:0050801;GO:0023056;GO:0034641;GO:0023052;GO:0023051;GO:0010647;GO:0010646;GO:0044246;GO:0007417;GO:0072507;GO:0072503;GO:1900736;GO:1900738;GO:0044238;GO:0045596;GO:0045595;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0055085;GO:0051093;GO:0032269;GO:0032268;GO:0043603;GO:0045861;GO:0031325;GO:0031324;GO:0031323;GO:1903169;GO:0071496;GO:0090303;GO:0045686;GO:0045685;GO:0040007;GO:0072376;GO:0072378;GO:0040008;GO:0010467;GO:0010468;GO:0048193;GO:0007154;GO:0048699;GO:0001932;GO:0007399;GO:0098655;GO:0001934; hemostasis;regulation of transport;blood coagulation, intrinsic pathway;blood coagulation;inorganic ion homeostasis;regulation of phosphate metabolic process;cellular response to stimulus;protein carboxylation;negative regulation of response to stimulus;regulation of platelet activation;regulation of response to stimulus;regulation of cell shape;negative regulation of homeostatic process;regulation of phosphorylation;positive regulation of phosphorylation;response to external stimulus;protein metabolic process;peptidyl-glutamic acid carboxylation;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;intracellular signal transduction;regulation of biological process;ER to Golgi vesicle-mediated transport;cell morphogenesis;calcium ion transmembrane import into cytosol;positive regulation of reactive oxygen species metabolic process;regulation of cytoplasmic transport;regulation of reactive oxygen species metabolic process;macromolecule modification;acute inflammatory response;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;positive regulation of signal transduction;regulation of cellular component organization;glial cell differentiation;regulation of cell development;positive regulation of G-protein coupled receptor protein signaling pathway;positive regulation of cell proliferation;regulation of body fluid levels;cell proliferation;cellular metal ion homeostasis;cellular calcium ion homeostasis;post-translational protein modification;cellular ion homeostasis;regulation of cell growth;multicellular organismal macromolecule metabolic process;positive regulation of multicellular organismal metabolic process;divalent inorganic cation transport;leukocyte migration;positive regulation of growth;regulation of cellular localization;homeostatic process;regulation of wound healing;negative regulation of wound healing;multicellular organism development;protein phosphorylation;cellular protein modification process;signal peptide processing;regulation of metal ion transport;single-organism transport;single-organism cellular process;locomotion;regulation of release of sequestered calcium ion into cytosol;anatomical structure development;phosphate-containing compound metabolic process;regulation of ion homeostasis;regulation of multicellular organismal development;phosphorus metabolic process;response to inactivity;negative regulation of cellular process;positive regulation of cellular process;signal transduction;cell surface receptor signaling pathway;single-organism metabolic process;single-organism biosynthetic process;phosphorylation;positive regulation of calcium ion transport into cytosol;regulation of calcium ion transport into cytosol;positive regulation of transport;calcium ion import into cytosol;peptidyl-glutamic acid modification;positive regulation of coagulation;nitrogen compound metabolic process;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;G-protein coupled receptor signaling pathway;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;sequestering of metal ion;maintenance of location;establishment of localization;single-organism developmental process;response to stimulus;positive regulation of collagen metabolic process;regulation of collagen metabolic process;negative regulation of nervous system development;regulation of nervous system development;peptide metabolic process;positive regulation of phosphorus metabolic process;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;collagen biosynthetic process;regulation of collagen biosynthetic process;positive regulation of collagen biosynthetic process;collagen metabolic process;single-organism process;regulation of neurogenesis;negative regulation of protein metabolic process;positive regulation of calcium ion import;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;negative regulation of neurogenesis;regulation of protein modification process;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;reactive oxygen species metabolic process;positive regulation of ion transport;positive regulation of phosphatidylinositol 3-kinase signaling;phosphatidylinositol 3-kinase signaling;regulation of phosphatidylinositol 3-kinase signaling;divalent metal ion transport;positive regulation of cation transmembrane transport;regulation of cation transmembrane transport;system development;regulation of cell activation;negative regulation of cell activation;cytosolic calcium ion transport;calcium ion transport into cytosol;metal ion homeostasis;neurogenesis;response to abiotic stimulus;positive regulation of calcium ion transport;regulation of calcium ion transport;cellular metabolic process;multicellular organism metabolic process;positive regulation of intracellular transport;regulation of metabolic process;regulation of intracellular transport;positive regulation of response to stimulus;cell development;positive regulation of homeostatic process;regulation of homeostatic process;cellular component organization or biogenesis;regulation of signal transduction;cellular developmental process;sequestering of calcium ion;release of sequestered calcium ion into cytosol;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;single organism signaling;cellular response to abiotic stimulus;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;immune system process;calcium ion import;regulation of cell morphogenesis;regulation of anatomical structure morphogenesis;cellular response to mechanical stimulus;movement of cell or subcellular component;localization of cell;macromolecule metabolic process;negative regulation of gliogenesis;regulation of gliogenesis;regulation of hemostasis;negative regulation of hemostasis;positive regulation of calcium ion transmembrane transport;cell migration;positive regulation of hemostasis;cation transport;ion transport;transport;calcium ion transport;astrocyte differentiation;defense response;response to stress;coagulation;inflammatory response;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;regulation of coagulation;negative regulation of coagulation;inositol lipid-mediated signaling;intracellular transport;acute-phase response;regulation of response to stress;positive regulation of protein modification process;cell activation;cell differentiation;peptidyl-amino acid modification;phosphatidylinositol-mediated signaling;regulation of fibrinolysis;positive regulation of cellular protein metabolic process;proteolysis;negative regulation of fibrinolysis;developmental process;multicellular organismal process;cellular process;protein processing;regulation of localization;cytosolic transport;protein maturation;regulation of ion transport;cellular component morphogenesis;organic substance metabolic process;regulation of phosphorus metabolic process;ion transmembrane transport;biosynthetic process;macromolecule biosynthetic process;establishment of localization in cell;localization;single-organism localization;cellular localization;regulation of cytosolic calcium ion concentration;single-organism intracellular transport;regulation of primary metabolic process;regulation of sequestering of calcium ion;negative regulation of sequestering of calcium ion;positive regulation of release of sequestered calcium ion into cytosol;regulation of G-protein coupled receptor protein signaling pathway;calcium ion homeostasis;positive regulation of transmembrane transport;regulation of ion transmembrane transport;positive regulation of ion transmembrane transport;regulation of transmembrane transport;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;response to wounding;response to mechanical stimulus;cellular homeostasis;regulation of macromolecule metabolic process;regulation of proteolysis;regulation of calcium ion import;platelet activation;cell motility;phospholipase C-activating G-protein coupled receptor signaling pathway;calcium ion transmembrane transport;positive regulation of cytosolic calcium ion concentration;chemical homeostasis;regulation of blood coagulation;negative regulation of blood coagulation;positive regulation of blood coagulation;negative regulation of astrocyte differentiation;regulation of astrocyte differentiation;positive regulation of cytoplasmic transport;organic substance biosynthetic process;cell growth;positive regulation of phosphate metabolic process;cellular component organization;negative regulation of platelet activation;biological regulation;inorganic cation transmembrane transport;inorganic ion transmembrane transport;regulation of biological quality;gliogenesis;wound healing;protein modification process;biological_process;metabolic process;fibrinolysis;positive regulation of cell growth;ion homeostasis;positive regulation of signaling;cellular nitrogen compound metabolic process;signaling;regulation of signaling;positive regulation of cell communication;regulation of cell communication;regulation of multicellular organismal metabolic process;central nervous system development;divalent inorganic cation homeostasis;cellular divalent inorganic cation homeostasis;regulation of phospholipase C-activating G-protein coupled receptor signaling pathway;positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway;primary metabolic process;negative regulation of cell differentiation;regulation of cell differentiation;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;transmembrane transport;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;cellular amide metabolic process;negative regulation of proteolysis;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of calcium ion transmembrane transport;cellular response to external stimulus;positive regulation of wound healing;negative regulation of glial cell differentiation;regulation of glial cell differentiation;growth;protein activation cascade;blood coagulation, fibrin clot formation;regulation of growth;gene expression;regulation of gene expression;Golgi vesicle transport;cell communication;generation of neurons;regulation of protein phosphorylation;nervous system development;cation transmembrane transport;positive regulation of protein phosphorylation; 5;4;4;5;7;6;3;7;3;5;3;4;3;7;7;3;4;8;3;3;4;5;2;7;5;8;5;6;5;5;6;5;5;4;4;6;5;5;4;4;3;8;9;7;6;4;5;4;7;3;3;4;4;6;5;4;7;6;6;6;4;3;2;5;3;5;4;4;4;3;3;3;4;5;3;4;6;4;5;3;7;8;4;3;5;3;4;5;3;4;3;3;4;3;3;3;2;5;5;4;5;5;5;4;4;4;5;6;6;6;2;6;5;6;3;3;5;5;5;6;5;4;4;4;4;6;8;6;8;6;6;4;4;4;10;6;8;6;3;5;7;3;4;4;3;5;3;4;3;3;2;4;4;5;5;5;2;2;4;3;4;4;5;3;2;10;5;4;5;4;3;4;6;7;4;4;6;4;4;6;5;4;9;6;4;3;4;5;5;5;4;4;6;5;7;4;6;4;5;7;7;6;5;5;3;2;2;2;6;3;6;5;5;4;3;5;5;3;5;4;2;3;3;10;5;4;4;4;5;5;9;4;5;5;4;4;4;4;4;4;4;6;6;5;3;6;8;11;5;5;5;5;7;7;5;4;3;6;3;5;2;7;6;3;7;5;5;1;2;6;4;6;3;4;2;3;4;4;4;5;8;8;6;6;3;4;4;7;7;7;5;4;3;5;5;5;6;4;4;4;7;4;5;7;7;2;3;4;3;5;5;6;4;7;7;5;6;7; GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0070013;GO:0016020;GO:0043230;GO:0043231;GO:0043233;GO:0072562;GO:0044432;GO:0044431;GO:0005788;GO:0005783;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0031012;GO:0005737;GO:0005794;GO:0005796;GO:0005623;GO:0005622;GO:0005886;GO:1903561;GO:0005575;GO:0005576; intracellular part;extracellular region part;organelle part;cell part;cell periphery;extracellular space;extracellular exosome;intracellular organelle lumen;membrane;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;blood microparticle;endoplasmic reticulum part;Golgi apparatus part;endoplasmic reticulum lumen;endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;extracellular matrix;cytoplasm;Golgi apparatus;Golgi lumen;cell;intracellular;plasma membrane;extracellular vesicle;cellular_component;extracellular region; 3;2;2;2;3;3;4;4;2;3;4;3;3;4;4;5;4;2;3;3;2;3;4;3;4;2;4;4;5;2;3;3;3;1;2; GO:0004252;GO:0017171;GO:0005488;GO:0016787;GO:0005509;GO:0070053;GO:0008083;GO:0005515;GO:0005102;GO:0004175;GO:0070011;GO:0060089;GO:0046872;GO:0003674;GO:0003824;GO:0008233;GO:0008236;GO:0043169;GO:0043167;GO:0038023;GO:0004872;GO:0004871; serine-type endopeptidase activity;serine hydrolase activity;binding;hydrolase activity;calcium ion binding;thrombospondin receptor activity;growth factor activity;protein binding;receptor binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides;molecular transducer activity;metal ion binding;molecular_function;catalytic activity;peptidase activity;serine-type peptidase activity;cation binding;ion binding;signaling receptor activity;receptor activity;signal transducer activity; 6;4;2;3;6;4;5;3;4;6;5;2;5;1;2;4;5;4;3;3;3;2; K01313 map04080;map04610;map04810; Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulation of actin cytoskeleton; IPR000001;IPR001254;IPR018056;IPR018992;IPR017857;IPR003966;IPR009003;IPR000294;IPR018114;IPR013806;IPR033116;IPR001314; Kringle;Serine proteases, trypsin domain;Kringle, conserved site;Thrombin light chain;Coagulation factor, subgroup, Gla domain;Prothrombin/thrombin;Peptidase S1, PA clan;Gamma-carboxyglutamic acid-rich (GLA) domain;Serine proteases, trypsin family, histidine active site;Kringle-like fold;Serine proteases, trypsin family, serine active site;Peptidase S1A, chymotrypsin family; extracellular 159897046 167.0 O [O] Posttranslational modification, protein turnover, chaperones; COG5640 Secreted trypsin-like serine protease O60423 Phospholipid-transporting ATPase IK OS=Homo sapiens OX=9606 GN=ATP8B3 PE=2 SV=4 - [AT8B3_HUMAN] 0.396 0.543 2.428 0.806 0.725 0.964 0.729281768 nan 1.111724138 nan 4.47145488 nan 1.329655172 nan GO:0071840;GO:0000003;GO:0010256;GO:0051704;GO:0044703;GO:0044702;GO:0009566;GO:0016043;GO:0008150;GO:0019953;GO:0044699;GO:0008037;GO:0009988;GO:0009987;GO:0035036;GO:0007339;GO:0007338;GO:0007030;GO:0022414;GO:0044763;GO:0006996; cellular component organization or biogenesis;reproduction;endomembrane system organization;multi-organism process;multi-organism reproductive process;single organism reproductive process;fertilization;cellular component organization;biological_process;sexual reproduction;single-organism process;cell recognition;cell-cell recognition;cellular process;sperm-egg recognition;binding of sperm to zona pellucida;single fertilization;Golgi organization;reproductive process;single-organism cellular process;organelle organization; 2;2;4;2;3;3;4;3;1;3;2;4;5;2;4;5;5;5;2;3;4; GO:0005783;GO:0005789;GO:0016023;GO:0016021;GO:0016020;GO:0031988;GO:0005794;GO:0099503;GO:0098588;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0044433;GO:0044432;GO:0031224;GO:0030141;GO:0012505;GO:0012506;GO:0031982;GO:0044446;GO:0044444;GO:0097708;GO:0042175;GO:0001669;GO:0005737;GO:0030667;GO:0031090;GO:0031410;GO:0097223;GO:0030659;GO:0044464;GO:0005623;GO:0005622;GO:0002080;GO:0071944;GO:0098805;GO:0005886;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;cytoplasmic, membrane-bounded vesicle;integral component of membrane;membrane;membrane-bounded vesicle;Golgi apparatus;secretory vesicle;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;cytoplasmic vesicle part;endoplasmic reticulum part;intrinsic component of membrane;secretory granule;endomembrane system;vesicle membrane;vesicle;intracellular organelle part;cytoplasmic part;intracellular vesicle;nuclear outer membrane-endoplasmic reticulum membrane network;acrosomal vesicle;cytoplasm;secretory granule membrane;organelle membrane;cytoplasmic vesicle;sperm part;cytoplasmic vesicle membrane;cell part;cell;intracellular;acrosomal membrane;cell periphery;whole membrane;plasma membrane;cellular_component; 4;3;5;4;2;5;4;6;4;4;3;2;2;3;3;2;4;4;3;4;3;4;4;3;4;4;3;4;4;4;3;5;3;5;2;2;3;4;3;3;3;1; GO:0004012;GO:1901363;GO:0005548;GO:0046872;GO:0005319;GO:0016818;GO:0097367;GO:0016817;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0042623;GO:0032549;GO:0017076;GO:0005524;GO:0016787;GO:0003824;GO:0022892;GO:0097159;GO:0043492;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0000166;GO:0043169;GO:0000287;GO:0043167;GO:0005215;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0036094;GO:0043168; phospholipid-translocating ATPase activity;heterocyclic compound binding;phospholipid transporter activity;metal ion binding;lipid transporter activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ATPase activity, coupled;ribonucleoside binding;purine nucleotide binding;ATP binding;hydrolase activity;catalytic activity;substrate-specific transporter activity;organic cyclic compound binding;ATPase activity, coupled to movement of substances;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;cation binding;magnesium ion binding;ion binding;transporter activity;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;small molecule binding;anion binding; 6;3;5;5;4;5;3;4;1;2;8;4;9;5;5;6;3;2;3;3;10;6;6;5;6;4;5;4;4;6;3;2;6;5;4;7;3;4; K01530 IPR008250;IPR023298;IPR023299;IPR030349;IPR023214;IPR018303;IPR006539;IPR032630;IPR032631;IPR001757; P-type ATPase, A domain;P-type ATPase, transmembrane domain;P-type ATPase, cytoplasmic domain N;Phospholipid-transporting ATPase IK;HAD-like domain;P-type ATPase, phosphorylation site;P-type ATPase, subfamily IV;P-type ATPase, C-terminal;P-type ATPase, N-terminal;P-type ATPase; plasma membrane Hs5031697 1093.0 R [R] General function prediction only; P00736 Complement C1r subcomponent OS=Homo sapiens OX=9606 GN=C1R PE=1 SV=2 - [C1R_HUMAN] 1 1.031 1.072 1.011 1.038 0.93 0.969932105 0.378961772 0.973988439 0.717586751 1.039767216 0.007693394 0.895953757 0.571347707 GO:0019724;GO:0048584;GO:0048583;GO:0044699;GO:0044710;GO:0006959;GO:0072376;GO:0050789;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:0045087;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0044238;GO:0050776;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0002455;GO:0050778;GO:0002443;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0006956; B cell mediated immunity;positive regulation of response to stimulus;regulation of response to stimulus;single-organism process;single-organism metabolic process;humoral immune response;protein activation cascade;regulation of biological process;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;innate immune response;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;complement activation, classical pathway;primary metabolic process;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;humoral immune response mediated by circulating immunoglobulin;positive regulation of immune response;leukocyte mediated immunity;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;complement activation; 6;3;3;2;3;4;3;2;3;3;3;2;2;4;4;3;7;1;2;3;5;3;4;5;5;4;2;5;4;4;4;2;4;3;3;4; GO:0043227;GO:0043226;GO:0005575;GO:0070062;GO:0005615;GO:0072562;GO:0005576;GO:1903561;GO:0031982;GO:0043230;GO:0044421; membrane-bounded organelle;organelle;cellular_component;extracellular exosome;extracellular space;blood microparticle;extracellular region;extracellular vesicle;vesicle;extracellular organelle;extracellular region part; 3;2;1;4;3;3;2;3;4;3;2; GO:0004252;GO:0004175;GO:0043169;GO:0003674;GO:0005488;GO:0008233;GO:0043167;GO:0008236;GO:0005509;GO:0046872;GO:0016787;GO:0017171;GO:0003824;GO:0070011; serine-type endopeptidase activity;endopeptidase activity;cation binding;molecular_function;binding;peptidase activity;ion binding;serine-type peptidase activity;calcium ion binding;metal ion binding;hydrolase activity;serine hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides; 6;6;4;1;2;4;3;5;6;5;3;4;2;5; K01330 map04145;map04610;map05133;map05150;map05322; Phagosome;Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus; IPR000152;IPR018097;IPR001254;IPR000859;IPR000436;IPR009003;IPR000742;IPR001314;IPR001881;IPR013032;IPR033116;IPR035707; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;CUB domain;Sushi/SCR/CCP domain;Peptidase S1, PA clan;EGF-like domain;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site;Complement subcomponent C1r; extracellular Hs4502493 1473.0 E [E] Amino acid transport and metabolism; P01859 Immunoglobulin heavy constant gamma 2 OS=Homo sapiens OX=9606 GN=IGHG2 PE=1 SV=2 - [IGHG2_HUMAN] 1.072 1.009 0.964 0.92 1.107 0.735 1.062438057 1.05E-05 0.831074977 1.17E-43 0.955401388 1.02E-18 0.66395664 0.851790853 GO:0006909;GO:0048584;GO:0048583;GO:0061024;GO:0007165;GO:0007166;GO:0002455;GO:0071840;GO:0044710;GO:0043207;GO:0009617;GO:0048518;GO:0002682;GO:0019724;GO:0046649;GO:0009607;GO:0051707;GO:0051704;GO:0044700;GO:0002429;GO:0016192;GO:0009605;GO:0019538;GO:0002376;GO:0045321;GO:0050789;GO:0002764;GO:0002431;GO:0002768;GO:0002433;GO:0016043;GO:0002684;GO:0065007;GO:0006810;GO:0051716;GO:0050794;GO:0006952;GO:0006950;GO:0016064;GO:0006956;GO:0008152;GO:0006955;GO:0006958;GO:0006959;GO:0038096;GO:0038094;GO:0002757;GO:0006897;GO:0038093;GO:0050896;GO:0001775;GO:0002694;GO:0002696;GO:0008150;GO:0023052;GO:0044699;GO:0051234;GO:0008037;GO:0009987;GO:0050871;GO:0098542;GO:0050776;GO:0002460;GO:0051251;GO:0050778;GO:0010324;GO:0043170;GO:0042742;GO:0050865;GO:0050864;GO:0050867;GO:0042113;GO:0072376;GO:0002443;GO:0071704;GO:0050851;GO:0050853;GO:0045087;GO:0006910;GO:0006911;GO:0002449;GO:0044765;GO:0044763;GO:0007154;GO:0051179;GO:1902578;GO:0044238;GO:0002250;GO:0002253;GO:0002252;GO:0051249;GO:0048522; phagocytosis;positive regulation of response to stimulus;regulation of response to stimulus;membrane organization;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;response to bacterium;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;lymphocyte activation;response to biotic stimulus;response to other organism;multi-organism process;single organism signaling;immune response-activating cell surface receptor signaling pathway;vesicle-mediated transport;response to external stimulus;protein metabolic process;immune system process;leukocyte activation;regulation of biological process;immune response-regulating signaling pathway;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;cellular component organization;positive regulation of immune system process;biological regulation;transport;cellular response to stimulus;regulation of cellular process;defense response;response to stress;immunoglobulin mediated immune response;complement activation;metabolic process;immune response;complement activation, classical pathway;humoral immune response;Fc-gamma receptor signaling pathway involved in phagocytosis;Fc-gamma receptor signaling pathway;immune response-activating signal transduction;endocytosis;Fc receptor signaling pathway;response to stimulus;cell activation;regulation of leukocyte activation;positive regulation of leukocyte activation;biological_process;signaling;single-organism process;establishment of localization;cell recognition;cellular process;positive regulation of B cell activation;defense response to other organism;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of lymphocyte activation;positive regulation of immune response;membrane invagination;macromolecule metabolic process;defense response to bacterium;regulation of cell activation;regulation of B cell activation;positive regulation of cell activation;B cell activation;protein activation cascade;leukocyte mediated immunity;organic substance metabolic process;antigen receptor-mediated signaling pathway;B cell receptor signaling pathway;innate immune response;phagocytosis, recognition;phagocytosis, engulfment;lymphocyte mediated immunity;single-organism transport;single-organism cellular process;cell communication;localization;single-organism localization;primary metabolic process;adaptive immune response;activation of immune response;immune effector process;regulation of lymphocyte activation;positive regulation of cellular process; 5;3;3;4;4;5;5;2;3;4;4;2;3;6;4;3;3;2;3;5;5;3;4;2;3;2;5;6;6;4;3;3;2;4;3;3;4;3;7;4;2;3;5;4;5;8;4;6;7;2;4;4;4;1;2;2;3;4;2;6;4;4;5;5;4;5;4;5;4;6;4;5;3;4;3;6;7;4;5;6;5;4;3;4;2;3;3;4;3;3;5;3; GO:0031982;GO:0043234;GO:0043230;GO:0044425;GO:0044421;GO:0009897;GO:0005623;GO:0043227;GO:0016020;GO:0042571;GO:0019814;GO:0044459;GO:0009986;GO:0044464;GO:0071944;GO:0098552;GO:0070062;GO:0043226;GO:0005886;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576;GO:0072562; vesicle;protein complex;extracellular organelle;membrane part;extracellular region part;external side of plasma membrane;cell;membrane-bounded organelle;membrane;immunoglobulin complex, circulating;immunoglobulin complex;plasma membrane part;cell surface;cell part;cell periphery;side of membrane;extracellular exosome;organelle;plasma membrane;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region;blood microparticle; 4;3;3;2;2;4;2;3;2;3;4;3;3;2;3;3;4;2;3;3;3;2;1;2;3; GO:0005488;GO:0003674;GO:0034987;GO:0003823;GO:0005515;GO:0005102; binding;molecular_function;immunoglobulin receptor binding;antigen binding;protein binding;receptor binding; 2;1;5;3;3;4; IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; mitochondria P0CG48 Polyubiquitin-C OS=Homo sapiens OX=9606 GN=UBC PE=1 SV=3 - [UBC_HUMAN] 1.028 0.992 0.846 1.411 0.977 1.162 1.036290323 nan 1.444216991 nan 0.852822581 nan 1.189355169 nan GO:0005737;GO:0043231;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0044424;GO:0043227;GO:0043226; cytoplasm;intracellular membrane-bounded organelle;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle;intracellular part;membrane-bounded organelle;organelle; 4;4;5;2;2;3;1;3;3;3;2; K08770 map03320; PPAR signaling pathway; IPR000626;IPR019956;IPR019954;IPR029071; Ubiquitin domain;Ubiquitin;Ubiquitin conserved site;Ubiquitin-related domain; cytosol Hs16163829 1350.0 OR [O] Posttranslational modification, protein turnover, chaperones;[R] General function prediction only; Q13275 Semaphorin-3F OS=Homo sapiens OX=9606 GN=SEMA3F PE=2 SV=2 - [SEM3F_HUMAN] 0.841 0.831 1.794 0.83 0.82 0.595 1.012033694 nan 1.012195122 nan 2.158844765 nan 0.725609756 nan GO:0048675;GO:0048589;GO:0048588;GO:0040017;GO:0048585;GO:0048468;GO:0030517;GO:0050920;GO:0007165;GO:0007166;GO:0030516;GO:0036486;GO:0036484;GO:0031345;GO:0031344;GO:0071840;GO:0014032;GO:0014033;GO:0051716;GO:0014031;GO:0048864;GO:0042330;GO:0048869;GO:0045665;GO:0045664;GO:0048513;GO:0010721;GO:0048518;GO:0048519;GO:1901166;GO:0048762;GO:0006935;GO:0061548;GO:0061549;GO:0048583;GO:0021636;GO:0021637;GO:0008361;GO:0010977;GO:0003002;GO:0010975;GO:0001755;GO:0040007;GO:0097485;GO:0044700;GO:0065008;GO:0044707;GO:0009605;GO:0048870;GO:0071526;GO:0007154;GO:0032535;GO:0022604;GO:0021785;GO:0050922;GO:0022603;GO:1902667;GO:0021602;GO:0006928;GO:0048486;GO:0051271;GO:0051674;GO:0031175;GO:0097491;GO:0050789;GO:0000904;GO:0016049;GO:0000902;GO:0016043;GO:0090066;GO:0065007;GO:0048640;GO:0016477;GO:0061564;GO:0009880;GO:0050793;GO:0009888;GO:0050794;GO:0048863;GO:0008150;GO:0051239;GO:0021545;GO:0007350;GO:0050896;GO:0051961;GO:0048812;GO:2000145;GO:2000147;GO:0021612;GO:0048638;GO:0032102;GO:0030308;GO:0032101;GO:0030154;GO:0051129;GO:0051128;GO:0009790;GO:0023052;GO:0060284;GO:0042221;GO:0021559;GO:0007411;GO:0001667;GO:0009653;GO:0044699;GO:0007417;GO:0061387;GO:0050767;GO:0051241;GO:0050768;GO:1902284;GO:1902285;GO:1902287;GO:0060560;GO:0032502;GO:0032501;GO:0009987;GO:0010769;GO:0048699;GO:0045596;GO:0045595;GO:0001558;GO:0021561;GO:0007409;GO:0021675;GO:0032879;GO:0032990;GO:0051093;GO:0050771;GO:0050770;GO:0048485;GO:0010771;GO:0048731;GO:0048483;GO:0097490;GO:0045926;GO:0030030;GO:0040013;GO:1902668;GO:0008045;GO:0035282;GO:0007275;GO:1990138;GO:0007389;GO:0048846;GO:0040008;GO:0048843;GO:0032989;GO:0051960;GO:0048532;GO:0048666;GO:0048667;GO:0030335;GO:0030334;GO:0048841;GO:0030182;GO:0021604;GO:0044767;GO:0044763;GO:0021610;GO:0060485;GO:0022008;GO:0051179;GO:0021783;GO:0035290;GO:0040011;GO:0051272;GO:0040012;GO:0048858;GO:0007399;GO:0048856;GO:0051270;GO:2000026;GO:0048523;GO:0048522; axon extension;developmental growth;developmental cell growth;positive regulation of locomotion;negative regulation of response to stimulus;cell development;negative regulation of axon extension;regulation of chemotaxis;signal transduction;cell surface receptor signaling pathway;regulation of axon extension;ventral trunk neural crest cell migration;trunk neural crest cell migration;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;neural crest cell development;neural crest cell differentiation;cellular response to stimulus;mesenchymal cell development;stem cell development;taxis;cellular developmental process;negative regulation of neuron differentiation;regulation of neuron differentiation;animal organ development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;neural crest cell migration involved in autonomic nervous system development;mesenchymal cell differentiation;chemotaxis;ganglion development;sympathetic ganglion development;regulation of response to stimulus;trigeminal nerve morphogenesis;trigeminal nerve structural organization;regulation of cell size;negative regulation of neuron projection development;regionalization;regulation of neuron projection development;neural crest cell migration;growth;neuron projection guidance;single organism signaling;regulation of biological quality;single-multicellular organism process;response to external stimulus;cell motility;semaphorin-plexin signaling pathway;cell communication;regulation of cellular component size;regulation of cell morphogenesis;branchiomotor neuron axon guidance;negative regulation of chemotaxis;regulation of anatomical structure morphogenesis;regulation of axon guidance;cranial nerve morphogenesis;movement of cell or subcellular component;parasympathetic nervous system development;negative regulation of cellular component movement;localization of cell;neuron projection development;sympathetic neuron projection guidance;regulation of biological process;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;cellular component organization;regulation of anatomical structure size;biological regulation;negative regulation of developmental growth;cell migration;axon development;embryonic pattern specification;regulation of developmental process;tissue development;regulation of cellular process;stem cell differentiation;biological_process;regulation of multicellular organismal process;cranial nerve development;blastoderm segmentation;response to stimulus;negative regulation of nervous system development;neuron projection morphogenesis;regulation of cell motility;positive regulation of cell motility;facial nerve structural organization;regulation of developmental growth;negative regulation of response to external stimulus;negative regulation of cell growth;regulation of response to external stimulus;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;embryo development;signaling;regulation of cell development;response to chemical;trigeminal nerve development;axon guidance;ameboidal-type cell migration;anatomical structure morphogenesis;single-organism process;central nervous system development;regulation of extent of cell growth;regulation of neurogenesis;negative regulation of multicellular organismal process;negative regulation of neurogenesis;neuron projection extension involved in neuron projection guidance;semaphorin-plexin signaling pathway involved in neuron projection guidance;semaphorin-plexin signaling pathway involved in axon guidance;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;cellular process;regulation of cell morphogenesis involved in differentiation;generation of neurons;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cell growth;facial nerve development;axonogenesis;nerve development;regulation of localization;cell part morphogenesis;negative regulation of developmental process;negative regulation of axonogenesis;regulation of axonogenesis;sympathetic nervous system development;negative regulation of cell morphogenesis involved in differentiation;system development;autonomic nervous system development;sympathetic neuron projection extension;negative regulation of growth;cell projection organization;negative regulation of locomotion;negative regulation of axon guidance;motor neuron axon guidance;segmentation;multicellular organism development;neuron projection extension;pattern specification process;axon extension involved in axon guidance;regulation of growth;negative regulation of axon extension involved in axon guidance;cellular component morphogenesis;regulation of nervous system development;anatomical structure arrangement;neuron development;cell morphogenesis involved in neuron differentiation;positive regulation of cell migration;regulation of cell migration;regulation of axon extension involved in axon guidance;neuron differentiation;cranial nerve structural organization;single-organism developmental process;single-organism cellular process;facial nerve morphogenesis;mesenchyme development;neurogenesis;localization;preganglionic parasympathetic fiber development;trunk segmentation;locomotion;positive regulation of cellular component movement;regulation of locomotion;cell projection morphogenesis;nervous system development;anatomical structure development;regulation of cellular component movement;regulation of multicellular organismal development;negative regulation of cellular process;positive regulation of cellular process; 6;3;4;3;3;4;5;4;4;5;5;8;7;5;5;2;7;7;3;6;5;3;4;6;7;4;5;2;2;6;6;4;5;6;3;5;6;5;6;5;6;6;2;5;3;3;3;3;3;6;4;4;5;8;4;4;5;4;4;5;4;3;5;6;2;5;3;5;3;4;2;4;4;6;5;3;4;3;6;1;3;5;6;2;4;6;4;4;6;4;4;4;4;5;4;4;5;2;5;3;6;6;5;3;2;5;5;6;3;5;6;6;7;4;2;2;2;6;7;4;4;4;6;7;4;3;5;3;6;7;5;5;4;5;6;3;4;3;5;7;6;4;5;4;7;3;6;4;5;4;5;6;5;5;6;6;5;3;3;5;5;6;2;5;7;2;4;3;5;5;3;4;4;3;3; GO:0044421;GO:0005615;GO:0005575;GO:0005576; extracellular region part;extracellular space;cellular_component;extracellular region; 2;3;1;2; GO:0045499;GO:0003674;GO:0005488;GO:0005515;GO:0005102;GO:0030215;GO:0038191; chemorepellent activity;molecular_function;binding;protein binding;receptor binding;semaphorin receptor binding;neuropilin binding; 2;1;2;3;4;5;5; K06840 map04360; Axon guidance; IPR003599;IPR007110;IPR013783;IPR003598;IPR027231;IPR015943;IPR016201;IPR001627; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin subtype 2;Semaphorin;WD40/YVTN repeat-like-containing domain;PSI domain;Sema domain; extracellular Hs4759090 1634.0 T [T] Signal transduction mechanisms; Q5T0Z8 Uncharacterized protein C6orf132 OS=Homo sapiens OX=9606 GN=C6orf132 PE=1 SV=4 - [CF132_HUMAN] 0.766 0.831 1.551 0.625 1.161 1.29 0.921780987 nan 0.538329027 nan 1.866425993 nan 1.111111111 nan nucleus P35573 Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3 - [GDE_HUMAN] 1.052 1.098 0.77 0.822 1.165 1.756 0.958105647 0.799116159 0.705579399 0.00275106 0.701275046 0.180905043 1.507296137 0.467534828 GO:0044281;GO:0044712;GO:0044710;GO:0044711;GO:0044275;GO:0006073;GO:0031960;GO:0010033;GO:0055114;GO:0009605;GO:0016052;GO:0031667;GO:0016051;GO:1901576;GO:0044264;GO:0044262;GO:0044260;GO:0009719;GO:0006112;GO:0044699;GO:0019318;GO:0008150;GO:0008152;GO:0044723;GO:0044724;GO:0044042;GO:0033692;GO:0015980;GO:0050896;GO:0005996;GO:0044248;GO:0044249;GO:0009250;GO:0009251;GO:0034645;GO:0014070;GO:0044247;GO:0005980;GO:0009987;GO:0034637;GO:0009725;GO:0043170;GO:0006006;GO:0048545;GO:0009991;GO:0051384;GO:0006091;GO:0033993;GO:0071704;GO:0007584;GO:0000271;GO:1901575;GO:0000272;GO:0009058;GO:0009059;GO:0044763;GO:0042221;GO:0009056;GO:0009057;GO:0044238;GO:0005975;GO:0005977;GO:0005976;GO:0005978;GO:0044237; small molecule metabolic process;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular carbohydrate catabolic process;cellular glucan metabolic process;response to corticosteroid;response to organic substance;oxidation-reduction process;response to external stimulus;carbohydrate catabolic process;response to nutrient levels;carbohydrate biosynthetic process;organic substance biosynthetic process;cellular polysaccharide metabolic process;cellular carbohydrate metabolic process;cellular macromolecule metabolic process;response to endogenous stimulus;energy reserve metabolic process;single-organism process;hexose metabolic process;biological_process;metabolic process;single-organism carbohydrate metabolic process;single-organism carbohydrate catabolic process;glucan metabolic process;cellular polysaccharide biosynthetic process;energy derivation by oxidation of organic compounds;response to stimulus;monosaccharide metabolic process;cellular catabolic process;cellular biosynthetic process;glucan biosynthetic process;glucan catabolic process;cellular macromolecule biosynthetic process;response to organic cyclic compound;cellular polysaccharide catabolic process;glycogen catabolic process;cellular process;cellular carbohydrate biosynthetic process;response to hormone;macromolecule metabolic process;glucose metabolic process;response to steroid hormone;response to extracellular stimulus;response to glucocorticoid;generation of precursor metabolites and energy;response to lipid;organic substance metabolic process;response to nutrient;polysaccharide biosynthetic process;organic substance catabolic process;polysaccharide catabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;response to chemical;catabolic process;macromolecule catabolic process;primary metabolic process;carbohydrate metabolic process;glycogen metabolic process;polysaccharide metabolic process;glycogen biosynthetic process;cellular metabolic process; 4;4;3;4;5;6;6;4;4;3;5;5;5;4;5;4;4;3;5;2;6;1;2;4;5;6;5;4;2;5;4;4;6;7;5;5;6;6;2;4;4;4;7;5;4;7;4;5;3;4;6;4;6;3;5;3;3;3;5;3;4;5;5;6;3; GO:0005783;GO:1902494;GO:0043234;GO:0043231;GO:0005829;GO:0044424;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0043033;GO:0044444;GO:0005737;GO:0005634;GO:0032991;GO:0044464;GO:0005623;GO:0016528;GO:0016529;GO:0016234;GO:0005575; endoplasmic reticulum;catalytic complex;protein complex;intracellular membrane-bounded organelle;cytosol;intracellular part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;isoamylase complex;cytoplasmic part;cytoplasm;nucleus;macromolecular complex;cell part;cell;sarcoplasm;sarcoplasmic reticulum;inclusion body;cellular_component; 4;4;3;4;5;3;3;3;3;2;3;5;4;4;5;2;2;2;5;5;4;1; GO:0016740;GO:0016757;GO:0004553;GO:0016758;GO:0004133;GO:0004134;GO:0004135;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0001871;GO:0016798;GO:0015926;GO:0030247;GO:0030246;GO:0090599; transferase activity;transferase activity, transferring glycosyl groups;hydrolase activity, hydrolyzing O-glycosyl compounds;transferase activity, transferring hexosyl groups;glycogen debranching enzyme activity;4-alpha-glucanotransferase activity;amylo-alpha-1,6-glucosidase activity;molecular_function;binding;hydrolase activity;catalytic activity;pattern binding;hydrolase activity, acting on glycosyl bonds;glucosidase activity;polysaccharide binding;carbohydrate binding;alpha-glucosidase activity; 3;4;5;5;3;4;4;1;2;3;2;3;4;6;4;3;7; K01196 map00500;map01100; Starch and sucrose metabolism;Metabolic pathways; IPR010401;IPR017853;IPR008928;IPR029436;IPR032788;IPR006421;IPR032792;IPR032790; Glycogen debranching enzyme;Glycoside hydrolase superfamily;Six-hairpin glycosidase-like;Eukaryotic glycogen debranching enzyme, N-terminal domain;Glycogen debranching enzyme, central domain;Glycogen debranching enzyme, metazoa;Glycogen debranching enzyme, glucanotransferase domain;Glycogen debranching enzyme, C-terminal; cytosol Hs4557275 3202.0 G [G] Carbohydrate transport and metabolism; P00738 Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 - [HPT_HUMAN] 0.826 0.616 1.627 0.907 0.579 2.046 1.340909091 8.09E-116 1.566493955 9.11E-271 2.641233766 nan 3.533678756 1.64E-174 GO:0019222;GO:0048585;GO:0048583;GO:0044712;GO:0044710;GO:0010310;GO:0009617;GO:0010727;GO:0044092;GO:0048518;GO:0048519;GO:0051704;GO:0010035;GO:0051707;GO:0050794;GO:0009607;GO:0016192;GO:0009605;GO:0051354;GO:0006953;GO:0002376;GO:0019538;GO:0033554;GO:0009056;GO:0009894;GO:0009895;GO:0009892;GO:1900408;GO:0000302;GO:0042744;GO:0043170;GO:0050789;GO:0051341;GO:0065007;GO:0065009;GO:2000378;GO:0050790;GO:0006810;GO:0051716;GO:2000377;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0002526;GO:0051234;GO:0006897;GO:0043207;GO:0042542;GO:0050896;GO:0006898;GO:0006954;GO:0044248;GO:0070887;GO:0043086;GO:0044699;GO:1902883;GO:0006508;GO:0031330;GO:0009987;GO:0072593;GO:0098542;GO:0006979;GO:1900407;GO:1901032;GO:1901031;GO:0042743;GO:0080134;GO:0042742;GO:0031329;GO:0031324;GO:0031323;GO:0010942;GO:0008219;GO:0010941;GO:2000295;GO:2000296;GO:0071704;GO:0044763;GO:0042221;GO:0034599;GO:1902882;GO:0051179;GO:1901700;GO:0044238;GO:0044237;GO:0080135;GO:0048523;GO:0048522; regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;single-organism catabolic process;single-organism metabolic process;regulation of hydrogen peroxide metabolic process;response to bacterium;negative regulation of hydrogen peroxide metabolic process;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;multi-organism process;response to inorganic substance;response to other organism;regulation of cellular process;response to biotic stimulus;vesicle-mediated transport;response to external stimulus;negative regulation of oxidoreductase activity;acute-phase response;immune system process;protein metabolic process;cellular response to stress;catabolic process;regulation of catabolic process;negative regulation of catabolic process;negative regulation of metabolic process;negative regulation of cellular response to oxidative stress;response to reactive oxygen species;hydrogen peroxide catabolic process;macromolecule metabolic process;regulation of biological process;regulation of oxidoreductase activity;biological regulation;regulation of molecular function;negative regulation of reactive oxygen species metabolic process;regulation of catalytic activity;transport;cellular response to stimulus;regulation of reactive oxygen species metabolic process;defense response;response to stress;biological_process;metabolic process;acute inflammatory response;establishment of localization;endocytosis;response to external biotic stimulus;response to hydrogen peroxide;response to stimulus;receptor-mediated endocytosis;inflammatory response;cellular catabolic process;cellular response to chemical stimulus;negative regulation of catalytic activity;single-organism process;negative regulation of response to oxidative stress;proteolysis;negative regulation of cellular catabolic process;cellular process;reactive oxygen species metabolic process;defense response to other organism;response to oxidative stress;regulation of cellular response to oxidative stress;negative regulation of response to reactive oxygen species;regulation of response to reactive oxygen species;hydrogen peroxide metabolic process;regulation of response to stress;defense response to bacterium;regulation of cellular catabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of cell death;cell death;regulation of cell death;regulation of hydrogen peroxide catabolic process;negative regulation of hydrogen peroxide catabolic process;organic substance metabolic process;single-organism cellular process;response to chemical;cellular response to oxidative stress;regulation of response to oxidative stress;localization;response to oxygen-containing compound;primary metabolic process;cellular metabolic process;regulation of cellular response to stress;negative regulation of cellular process;positive regulation of cellular process; 3;3;3;4;3;6;4;6;4;2;2;2;4;3;3;3;5;3;4;7;2;4;4;3;4;4;3;4;5;4;4;2;4;2;3;5;4;4;3;5;4;3;1;2;6;3;6;4;5;2;7;5;4;4;5;2;4;5;5;2;4;4;4;5;5;6;5;4;5;5;4;4;4;4;4;5;5;3;3;3;5;5;2;4;3;3;4;3;3; GO:0031974;GO:0031983;GO:0031982;GO:0071682;GO:0016023;GO:0031988;GO:0043230;GO:0043231;GO:0043234;GO:0043233;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0072562;GO:0044433;GO:0097708;GO:0044446;GO:0044444;GO:0060205;GO:0005737;GO:0031410;GO:0031838;GO:0044464;GO:0005623;GO:0005622;GO:0030139;GO:0005615;GO:0043226;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;endocytic vesicle lumen;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;extracellular organelle;intracellular membrane-bounded organelle;protein complex;organelle lumen;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;blood microparticle;cytoplasmic vesicle part;intracellular vesicle;intracellular organelle part;cytoplasmic part;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;cytoplasmic vesicle;haptoglobin-hemoglobin complex;cell part;cell;intracellular;endocytic vesicle;extracellular space;organelle;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;extracellular region; 2;4;4;6;5;5;3;4;3;3;3;2;2;3;3;3;4;4;3;4;5;4;5;4;2;2;3;6;3;2;3;4;2;1;2; GO:0004252;GO:0017171;GO:0016209;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0008233;GO:0008236;GO:0030492;GO:0005515;GO:0004175;GO:0070011; serine-type endopeptidase activity;serine hydrolase activity;antioxidant activity;molecular_function;binding;hydrolase activity;catalytic activity;peptidase activity;serine-type peptidase activity;hemoglobin binding;protein binding;endopeptidase activity;peptidase activity, acting on L-amino acid peptides; 6;4;2;1;2;3;2;4;5;4;3;6;5; K16142 IPR001314;IPR009003;IPR001254;IPR008292;IPR000436; Peptidase S1A, chymotrypsin family;Peptidase S1, PA clan;Serine proteases, trypsin domain;Haptoglobin;Sushi/SCR/CCP domain; extracellular Hs4826762 846.0 E [E] Amino acid transport and metabolism; P01857 Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=1 - [IGHG1_HUMAN] 1.41 0.835 0.895 1.073 0.861 0.755 1.688622754 1.48E-190 1.246225319 5.34E-68 1.071856287 0.000223071 0.87688734 1.02E-23 IPR007110;IPR013783;IPR003597;IPR003006; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin C1-set;Immunoglobulin/major histocompatibility complex, conserved site; extracellular Q66K66 Transmembrane protein 198 OS=Homo sapiens OX=9606 GN=TMEM198 PE=1 SV=1 - [TM198_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0030111;GO:0048856;GO:0090263;GO:0048584;GO:0048583;GO:0007275;GO:0023056;GO:0050789;GO:0023052;GO:0007165;GO:0007166;GO:0023051;GO:0010647;GO:0010646;GO:0051716;GO:0065007;GO:0044699;GO:0048518;GO:0032502;GO:0032501;GO:0009987;GO:0050794;GO:0044767;GO:0060070;GO:0008150;GO:0007154;GO:0009966;GO:0044700;GO:0044707;GO:0050896;GO:0016055;GO:0030177;GO:0044763;GO:0009967;GO:0060828;GO:0048522; regulation of Wnt signaling pathway;anatomical structure development;positive regulation of canonical Wnt signaling pathway;positive regulation of response to stimulus;regulation of response to stimulus;multicellular organism development;positive regulation of signaling;regulation of biological process;signaling;signal transduction;cell surface receptor signaling pathway;regulation of signaling;positive regulation of cell communication;regulation of cell communication;cellular response to stimulus;biological regulation;single-organism process;positive regulation of biological process;developmental process;multicellular organismal process;cellular process;regulation of cellular process;single-organism developmental process;canonical Wnt signaling pathway;biological_process;cell communication;regulation of signal transduction;single organism signaling;single-multicellular organism process;response to stimulus;Wnt signaling pathway;positive regulation of Wnt signaling pathway;single-organism cellular process;positive regulation of signal transduction;regulation of canonical Wnt signaling pathway;positive regulation of cellular process; 5;3;6;3;3;4;3;2;2;4;5;3;4;4;3;2;2;2;2;2;2;3;3;7;1;4;4;3;3;2;6;5;3;4;6;3; GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0031982;GO:0016023;GO:0031410;GO:0016021;GO:0016020;GO:0031988;GO:0097708;GO:0005886;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044425; intracellular organelle;cell periphery;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;vesicle;cytoplasmic, membrane-bounded vesicle;cytoplasmic vesicle;integral component of membrane;membrane;membrane-bounded vesicle;intracellular vesicle;plasma membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;membrane part; 3;3;3;2;3;4;4;5;5;4;2;5;4;3;4;2;2;3;1;4;3;2; IPR025256; Domain of unknown function DUF4203; plasma membrane Q96L73 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific OS=Homo sapiens OX=9606 GN=NSD1 PE=1 SV=1 - [NSD1_HUMAN] 0.829 1.77 0.564 0.974 1.216 0.887 0.468361582 nan 0.800986842 nan 0.318644068 nan 0.729440789 nan GO:0006479;GO:0019220;GO:0080090;GO:0019222;GO:2000113;GO:0031056;GO:1901362;GO:0071840;GO:0044710;GO:0010605;GO:0010604;GO:0018193;GO:0048518;GO:0016571;GO:0060255;GO:0034770;GO:0031060;GO:2001141;GO:0046483;GO:0042325;GO:0018209;GO:0019538;GO:0018205;GO:0019438;GO:0016568;GO:0016569;GO:0051098;GO:0009892;GO:0009893;GO:0009890;GO:0018022;GO:0051101;GO:0051254;GO:0010629;GO:0006807;GO:0050789;GO:0097659;GO:0044267;GO:0044260;GO:0016043;GO:0065007;GO:0016570;GO:1903308;GO:0006366;GO:0065009;GO:0032259;GO:0018130;GO:0006139;GO:0009889;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:1903025;GO:0016070;GO:1902679;GO:0044271;GO:0006355;GO:0010557;GO:0006357;GO:0006351;GO:0043414;GO:0010558;GO:0033044;GO:0032774;GO:0033043;GO:0016310;GO:0051128;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0000414;GO:0000122;GO:0009891;GO:0051246;GO:0031327;GO:0034968;GO:0031326;GO:1903508;GO:0031399;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0045893;GO:0048519;GO:0090304;GO:0032268;GO:0051253;GO:0051252;GO:0043170;GO:1902680;GO:1902275;GO:0018105;GO:0031328;GO:0043933;GO:0033135;GO:0031325;GO:0031324;GO:0031323;GO:0008213;GO:2000677;GO:0010628;GO:0006325;GO:1901360;GO:2000112;GO:0006796;GO:0071704;GO:0010467;GO:0010556;GO:0010468;GO:0006468;GO:0009987;GO:0045935;GO:0045934;GO:1901576;GO:0019219;GO:0006464;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0051173;GO:0006996;GO:0044238;GO:0051276;GO:0010452;GO:0044237;GO:1902589;GO:0048523;GO:0006793;GO:0001932;GO:0048522; protein methylation;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of cellular macromolecule biosynthetic process;regulation of histone modification;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;single-organism metabolic process;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;peptidyl-amino acid modification;positive regulation of biological process;histone methylation;regulation of macromolecule metabolic process;histone H4-K20 methylation;regulation of histone methylation;regulation of RNA biosynthetic process;heterocycle metabolic process;regulation of phosphorylation;peptidyl-serine modification;protein metabolic process;peptidyl-lysine modification;aromatic compound biosynthetic process;chromatin modification;covalent chromatin modification;regulation of binding;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;peptidyl-lysine methylation;regulation of DNA binding;positive regulation of RNA metabolic process;negative regulation of gene expression;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;histone modification;regulation of chromatin modification;transcription from RNA polymerase II promoter;regulation of molecular function;methylation;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of biosynthetic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;regulation of RNA polymerase II regulatory region sequence-specific DNA binding;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;macromolecule methylation;negative regulation of macromolecule biosynthetic process;regulation of chromosome organization;RNA biosynthetic process;regulation of organelle organization;phosphorylation;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;regulation of histone H3-K36 methylation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of biosynthetic process;regulation of protein metabolic process;negative regulation of cellular biosynthetic process;histone lysine methylation;regulation of cellular biosynthetic process;positive regulation of nucleic acid-templated transcription;regulation of protein modification process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;negative regulation of biological process;nucleic acid metabolic process;regulation of cellular protein metabolic process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;regulation of chromatin organization;peptidyl-serine phosphorylation;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of peptidyl-serine phosphorylation;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;protein alkylation;regulation of transcription regulatory region DNA binding;positive regulation of gene expression;chromatin organization;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;phosphate-containing compound metabolic process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;regulation of gene expression;protein phosphorylation;cellular process;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;organelle organization;primary metabolic process;chromosome organization;histone H3-K36 methylation;cellular metabolic process;single-organism organelle organization;negative regulation of cellular process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of cellular process; 5;6;4;3;6;5;5;2;3;4;4;7;2;5;4;7;6;6;4;7;8;4;8;5;6;7;4;3;3;4;6;5;5;5;3;2;7;5;4;3;2;4;7;7;3;3;5;4;4;3;5;5;1;2;5;7;5;6;5;6;5;7;6;4;5;6;6;5;6;4;4;4;5;2;7;7;4;5;5;6;5;7;6;4;7;7;6;6;2;5;5;5;5;4;6;6;8;5;4;8;4;4;4;7;6;5;5;4;6;5;3;5;5;5;7;2;5;5;4;5;6;5;3;5;3;4;4;4;4;3;5;7;3;4;3;4;7;3; GO:0031974;GO:0031981;GO:0044422;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0044464;GO:0043229;GO:0005623;GO:0043228;GO:0043226;GO:0005694;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;organelle part;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;cell part;intracellular organelle;cell;non-membrane-bounded organelle;organelle;chromosome;cellular_component;intracellular organelle lumen; 2;5;2;4;4;3;4;3;3;3;5;3;5;2;3;2;3;2;5;1;4; GO:0050681;GO:0008276;GO:0008270;GO:1901363;GO:0003714;GO:0003712;GO:0001047;GO:0016740;GO:0016741;GO:0046872;GO:0046975;GO:0000989;GO:0000988;GO:0001067;GO:0046966;GO:0046965;GO:0044212;GO:0018024;GO:0016278;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0008168;GO:0035258;GO:0035257;GO:0003824;GO:0097159;GO:0000976;GO:0000975;GO:0000979;GO:0001046;GO:0042054;GO:0043169;GO:1990837;GO:0043565;GO:0043167;GO:0003690;GO:0001012;GO:0008134;GO:0051427;GO:0016279;GO:0042799;GO:0005515;GO:0044877;GO:0005102;GO:0003682;GO:0000977;GO:0030331;GO:0008757;GO:0008170;GO:0042974;GO:0046914; androgen receptor binding;protein methyltransferase activity;zinc ion binding;heterocyclic compound binding;transcription corepressor activity;transcription cofactor activity;core promoter binding;transferase activity;transferase activity, transferring one-carbon groups;metal ion binding;histone methyltransferase activity (H3-K36 specific);transcription factor activity, transcription factor binding;transcription factor activity, protein binding;regulatory region nucleic acid binding;thyroid hormone receptor binding;retinoid X receptor binding;transcription regulatory region DNA binding;histone-lysine N-methyltransferase activity;lysine N-methyltransferase activity;molecular_function;binding;nucleic acid binding;DNA binding;methyltransferase activity;steroid hormone receptor binding;nuclear hormone receptor binding;catalytic activity;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter sequence-specific DNA binding;core promoter sequence-specific DNA binding;histone methyltransferase activity;cation binding;sequence-specific double-stranded DNA binding;sequence-specific DNA binding;ion binding;double-stranded DNA binding;RNA polymerase II regulatory region DNA binding;transcription factor binding;hormone receptor binding;protein-lysine N-methyltransferase activity;histone methyltransferase activity (H4-K20 specific);protein binding;macromolecular complex binding;receptor binding;chromatin binding;RNA polymerase II regulatory region sequence-specific DNA binding;estrogen receptor binding;S-adenosylmethionine-dependent methyltransferase activity;N-methyltransferase activity;retinoic acid receptor binding;transition metal ion binding; 8;6;7;3;5;4;8;3;4;5;9;3;2;5;5;6;7;8;7;1;2;4;5;5;7;6;2;3;8;6;10;9;7;4;7;6;3;6;8;4;5;7;9;3;3;4;4;9;8;6;6;5;6; K15588 map00310; Lysine degradation; IPR019787;IPR019786;IPR000313;IPR011011;IPR006560;IPR003616;IPR013083;IPR001214;IPR001965; Zinc finger, PHD-finger;Zinc finger, PHD-type, conserved site;PWWP domain;Zinc finger, FYVE/PHD-type;AWS domain;Post-SET domain;Zinc finger, RING/FYVE/PHD-type;SET domain;Zinc finger, PHD-type; nucleus Hs19923586 5565.0 K [K] Transcription; Q8N7E2 E3 ubiquitin-protein ligase CBLL2 OS=Homo sapiens OX=9606 GN=CBLL2 PE=1 SV=1 - [CBLL2_HUMAN] 0.71 0.998 1.565 0.934 0.927 0.829 0.711422846 nan 1.007551241 nan 1.568136273 nan 0.894282632 nan GO:0030155;GO:0050789;GO:0065007;GO:0022610;GO:0009987;GO:0050794;GO:0008150;GO:0007155; regulation of cell adhesion;regulation of biological process;biological regulation;biological adhesion;cellular process;regulation of cellular process;biological_process;cell adhesion; 4;2;2;2;2;3;1;3; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;cell part;cell;intracellular;cellular_component;intracellular part; 4;2;2;3;1;3; GO:0003674;GO:0004842;GO:0043169;GO:0046914;GO:0061630;GO:0008270;GO:0043167;GO:0016740;GO:0019787;GO:0003824;GO:0016874;GO:0061659;GO:0046872;GO:0005488; molecular_function;ubiquitin-protein transferase activity;cation binding;transition metal ion binding;ubiquitin protein ligase activity;zinc ion binding;ion binding;transferase activity;ubiquitin-like protein transferase activity;catalytic activity;ligase activity;ubiquitin-like protein ligase activity;metal ion binding;binding; 1;5;4;6;6;7;3;3;4;2;3;5;5;2; K15714 IPR013087;IPR001841;IPR013083;IPR017907; Zinc finger C2H2-type;Zinc finger, RING-type;Zinc finger, RING/FYVE/PHD-type;Zinc finger, RING-type, conserved site; nucleus Hs22054178 874.0 O [O] Posttranslational modification, protein turnover, chaperones; Q96Q11 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2 - [TRNT1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0008104;GO:0007005;GO:0044710;GO:0090646;GO:0070727;GO:0071840;GO:0033036;GO:0034470;GO:0006605;GO:0045184;GO:0072655;GO:0006839;GO:0046483;GO:0070585;GO:0006807;GO:0034660;GO:0043170;GO:0044260;GO:0006886;GO:0016043;GO:0001680;GO:1901360;GO:0006626;GO:0006810;GO:0008150;GO:0008152;GO:0051234;GO:0016070;GO:0046907;GO:0043628;GO:0034641;GO:0044699;GO:0006139;GO:0000963;GO:0008033;GO:0072594;GO:0009987;GO:0006725;GO:0033365;GO:0000959;GO:0090304;GO:0071704;GO:0010467;GO:0042780;GO:0071702;GO:0034613;GO:0031123;GO:0044765;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0044237;GO:0006399;GO:1902589;GO:0015031;GO:1902582;GO:1902580;GO:0006396; protein localization;mitochondrion organization;single-organism metabolic process;mitochondrial tRNA processing;cellular macromolecule localization;cellular component organization or biogenesis;macromolecule localization;ncRNA processing;protein targeting;establishment of protein localization;establishment of protein localization to mitochondrion;mitochondrial transport;heterocycle metabolic process;protein localization to mitochondrion;nitrogen compound metabolic process;ncRNA metabolic process;macromolecule metabolic process;cellular macromolecule metabolic process;intracellular protein transport;cellular component organization;tRNA 3'-terminal CCA addition;organic cyclic compound metabolic process;protein targeting to mitochondrion;transport;biological_process;metabolic process;establishment of localization;RNA metabolic process;intracellular transport;ncRNA 3'-end processing;cellular nitrogen compound metabolic process;single-organism process;nucleobase-containing compound metabolic process;mitochondrial RNA processing;tRNA processing;establishment of protein localization to organelle;cellular process;cellular aromatic compound metabolic process;protein localization to organelle;mitochondrial RNA metabolic process;nucleic acid metabolic process;organic substance metabolic process;gene expression;tRNA 3'-end processing;organic substance transport;cellular protein localization;RNA 3'-end processing;single-organism transport;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;cellular metabolic process;tRNA metabolic process;single-organism organelle organization;protein transport;single-organism intracellular transport;single-organism cellular localization;RNA processing; 4;5;3;5;4;2;3;7;6;4;6;6;4;7;3;6;4;4;6;3;10;4;5;4;1;2;3;5;5;8;4;2;4;4;8;5;2;4;6;6;5;3;5;9;5;5;7;4;3;4;2;3;3;4;3;3;7;4;5;5;4;6; GO:0031974;GO:0031981;GO:0043231;GO:0043233;GO:0044428;GO:0044429;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0005654;GO:0044446;GO:0044444;GO:0005737;GO:0005634;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0070013;GO:0005759;GO:0005575; membrane-enclosed lumen;nuclear lumen;intracellular membrane-bounded organelle;organelle lumen;nuclear part;mitochondrial part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoplasm;intracellular organelle part;cytoplasmic part;cytoplasm;nucleus;mitochondrion;cell part;cell;intracellular;intracellular organelle lumen;mitochondrial matrix;cellular_component; 2;5;4;3;4;4;3;2;3;3;2;5;3;4;4;5;5;2;2;3;4;5;1; GO:1901363;GO:0004810;GO:0000166;GO:0016740;GO:0097367;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0003824;GO:0016779;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0052927;GO:0035639;GO:0052928;GO:0052929;GO:0000049;GO:0043167;GO:0030554;GO:0003723;GO:0097159;GO:0001883;GO:0001882;GO:0070566;GO:0036094; heterocyclic compound binding;tRNA adenylyltransferase activity;nucleotide binding;transferase activity;carbohydrate derivative binding;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;catalytic activity;nucleotidyltransferase activity;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;CTP:tRNA cytidylyltransferase activity;purine ribonucleoside triphosphate binding;CTP:3'-cytidine-tRNA cytidylyltransferase activity;ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity;tRNA binding;ion binding;adenyl nucleotide binding;RNA binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;adenylyltransferase activity;small molecule binding; 3;7;4;3;3;1;2;4;4;5;5;6;4;2;5;4;6;5;6;4;6;5;6;8;6;3;6;5;3;5;4;6;3; K00974 map03013; RNA transport; IPR032828;IPR002646; tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain;Poly A polymerase, head domain; mitochondria Hs7705763 833.0 J [J] Translation, ribosomal structure and biogenesis; Q9P1T7 MyoD family inhibitor domain-containing protein OS=Homo sapiens OX=9606 GN=MDFIC PE=1 SV=2 - [MDFIC_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0033157;GO:0051169;GO:0008104;GO:0019220;GO:0080090;GO:0019222;GO:0051049;GO:0032386;GO:0048584;GO:0048583;GO:0032147;GO:0030111;GO:0007165;GO:0007166;GO:1901362;GO:0023014;GO:0051716;GO:0032879;GO:0010605;GO:0010604;GO:0070727;GO:0009966;GO:0009967;GO:0000165;GO:0044419;GO:1904590;GO:0019058;GO:0044093;GO:0048518;GO:0048519;GO:0051704;GO:1903828;GO:0042306;GO:0051051;GO:0060255;GO:0045859;GO:0006606;GO:0006605;GO:0045184;GO:0046330;GO:2001141;GO:0046483;GO:0042325;GO:0044700;GO:0042327;GO:0019538;GO:0016055;GO:0034641;GO:0033554;GO:0019438;GO:0033036;GO:0009892;GO:0009893;GO:0009890;GO:0033674;GO:1903650;GO:1900180;GO:0051254;GO:0071902;GO:0035556;GO:0071900;GO:0097659;GO:0045934;GO:0044267;GO:0032387;GO:0051347;GO:0044260;GO:0043900;GO:0006886;GO:0043549;GO:1903533;GO:0065007;GO:0044699;GO:0019083;GO:0065009;GO:0032880;GO:0018130;GO:0070201;GO:0006810;GO:1903649;GO:0006139;GO:0050792;GO:0050790;GO:0009889;GO:0044710;GO:0050794;GO:0043410;GO:1904589;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0042308;GO:0034654;GO:1902533;GO:1902531;GO:0048524;GO:0016070;GO:1902679;GO:0044271;GO:0046907;GO:0043903;GO:0050896;GO:0031401;GO:0043412;GO:0051338;GO:0006355;GO:0009059;GO:0046822;GO:0006351;GO:0051170;GO:0010562;GO:0051171;GO:0034504;GO:0032774;GO:0016310;GO:0051649;GO:0051247;GO:0023056;GO:0043406;GO:0043405;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043085;GO:0043408;GO:0007257;GO:0007254;GO:0051234;GO:1903900;GO:1903902;GO:0010557;GO:0009891;GO:0051246;GO:0031098;GO:0044765;GO:0019080;GO:0032270;GO:0046782;GO:0031399;GO:1904950;GO:0050434;GO:1903508;GO:1900181;GO:0043170;GO:1902582;GO:1902593;GO:0070302;GO:0072594;GO:0009987;GO:0006725;GO:0070304;GO:1903507;GO:0032872;GO:0045892;GO:0045893;GO:0032874;GO:0044744;GO:0044764;GO:0016482;GO:0032268;GO:0051253;GO:0051252;GO:0010629;GO:1902680;GO:0006807;GO:0033365;GO:0044033;GO:0045860;GO:0043902;GO:0080134;GO:0000187;GO:0080135;GO:0060341;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0046328;GO:0043506;GO:0043507;GO:0010628;GO:0051223;GO:0051224;GO:1901360;GO:2000112;GO:2000113;GO:1903827;GO:0050789;GO:0071704;GO:0010467;GO:0010556;GO:0071702;GO:0010468;GO:0046823;GO:0006468;GO:0017038;GO:0045935;GO:0045937;GO:1901576;GO:0019219;GO:0034613;GO:0090317;GO:0006913;GO:0006464;GO:0051174;GO:0009058;GO:0051403;GO:0044763;GO:1903506;GO:0051172;GO:0051173;GO:0007154;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:1902580;GO:0044237;GO:0010558;GO:0006796;GO:0016032;GO:0006793;GO:0015031;GO:0044403;GO:0001932;GO:0044249;GO:0001934;GO:0048523;GO:0048522; regulation of intracellular protein transport;nuclear transport;protein localization;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;regulation of intracellular transport;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;signal transduction by protein phosphorylation;cellular response to stimulus;regulation of localization;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;interspecies interaction between organisms;negative regulation of protein import;viral life cycle;positive regulation of molecular function;positive regulation of biological process;negative regulation of biological process;multi-organism process;negative regulation of cellular protein localization;regulation of protein import into nucleus;negative regulation of transport;regulation of macromolecule metabolic process;regulation of protein kinase activity;protein import into nucleus;protein targeting;establishment of protein localization;positive regulation of JNK cascade;regulation of RNA biosynthetic process;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;protein metabolic process;Wnt signaling pathway;cellular nitrogen compound metabolic process;cellular response to stress;aromatic compound biosynthetic process;macromolecule localization;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of kinase activity;negative regulation of cytoplasmic transport;regulation of protein localization to nucleus;positive regulation of RNA metabolic process;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;nucleic acid-templated transcription;negative regulation of nucleobase-containing compound metabolic process;cellular protein metabolic process;negative regulation of intracellular transport;positive regulation of transferase activity;cellular macromolecule metabolic process;regulation of multi-organism process;intracellular protein transport;regulation of kinase activity;regulation of protein targeting;biological regulation;single-organism process;viral transcription;regulation of molecular function;regulation of protein localization;heterocycle biosynthetic process;regulation of establishment of protein localization;transport;regulation of cytoplasmic transport;nucleobase-containing compound metabolic process;regulation of viral process;regulation of catalytic activity;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;regulation of protein import;response to stress;protein modification process;biological_process;metabolic process;negative regulation of protein import into nucleus;nucleobase-containing compound biosynthetic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;positive regulation of viral process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;intracellular transport;regulation of symbiosis, encompassing mutualism through parasitism;response to stimulus;positive regulation of protein modification process;macromolecule modification;regulation of transferase activity;regulation of transcription, DNA-templated;macromolecule biosynthetic process;regulation of nucleocytoplasmic transport;transcription, DNA-templated;nuclear import;positive regulation of phosphorus metabolic process;regulation of nitrogen compound metabolic process;protein localization to nucleus;RNA biosynthetic process;phosphorylation;establishment of localization in cell;positive regulation of protein metabolic process;positive regulation of signaling;positive regulation of MAP kinase activity;regulation of MAP kinase activity;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;positive regulation of catalytic activity;regulation of MAPK cascade;activation of JUN kinase activity;JNK cascade;establishment of localization;regulation of viral life cycle;positive regulation of viral life cycle;positive regulation of macromolecule biosynthetic process;positive regulation of biosynthetic process;regulation of protein metabolic process;stress-activated protein kinase signaling cascade;single-organism transport;viral gene expression;positive regulation of cellular protein metabolic process;regulation of viral transcription;regulation of protein modification process;negative regulation of establishment of protein localization;positive regulation of viral transcription;positive regulation of nucleic acid-templated transcription;negative regulation of protein localization to nucleus;macromolecule metabolic process;single-organism intracellular transport;single-organism nuclear import;regulation of stress-activated protein kinase signaling cascade;establishment of protein localization to organelle;cellular process;cellular aromatic compound metabolic process;positive regulation of stress-activated protein kinase signaling cascade;negative regulation of nucleic acid-templated transcription;regulation of stress-activated MAPK cascade;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;positive regulation of stress-activated MAPK cascade;protein targeting to nucleus;multi-organism cellular process;cytosolic transport;regulation of cellular protein metabolic process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;protein localization to organelle;multi-organism metabolic process;positive regulation of protein kinase activity;positive regulation of multi-organism process;regulation of response to stress;activation of MAPK activity;regulation of cellular response to stress;regulation of cellular localization;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of JNK cascade;regulation of JUN kinase activity;positive regulation of JUN kinase activity;positive regulation of gene expression;regulation of protein transport;negative regulation of protein transport;organic cyclic compound metabolic process;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of cellular protein localization;regulation of biological process;organic substance metabolic process;gene expression;regulation of macromolecule biosynthetic process;organic substance transport;regulation of gene expression;negative regulation of nucleocytoplasmic transport;protein phosphorylation;protein import;positive regulation of nucleobase-containing compound metabolic process;positive regulation of phosphate metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;cellular protein localization;negative regulation of intracellular protein transport;nucleocytoplasmic transport;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;stress-activated MAPK cascade;single-organism cellular process;regulation of nucleic acid-templated transcription;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell communication;localization;single-organism localization;cellular localization;primary metabolic process;single-organism cellular localization;cellular metabolic process;negative regulation of macromolecule biosynthetic process;phosphate-containing compound metabolic process;viral process;phosphorus metabolic process;protein transport;symbiosis, encompassing mutualism through parasitism;regulation of protein phosphorylation;cellular biosynthetic process;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;6;4;6;4;3;4;5;3;3;9;5;4;5;5;4;3;3;4;4;4;4;4;5;3;5;5;4;2;2;2;3;6;3;4;7;5;6;4;8;6;4;7;3;7;4;6;4;4;5;3;3;3;4;7;5;6;5;9;5;8;7;5;5;4;6;4;3;6;6;7;2;2;5;3;4;5;5;4;6;4;4;4;4;3;3;6;6;3;5;1;2;5;5;5;5;4;5;6;5;5;4;2;6;5;5;6;5;7;6;8;5;4;7;6;6;4;5;3;7;7;2;5;3;4;4;5;6;8;7;3;5;5;5;4;5;5;4;4;5;6;6;3;6;7;4;4;5;6;5;5;2;4;6;7;6;6;6;7;5;3;6;5;5;5;5;6;3;6;3;8;3;4;8;4;4;5;5;5;4;4;4;5;7;8;8;5;5;4;4;6;6;5;2;3;5;5;5;5;6;7;5;5;6;4;5;5;4;7;6;5;3;6;3;7;4;4;4;2;3;3;3;4;3;5;5;4;4;5;4;7;4;7;3;3; GO:0031974;GO:0031981;GO:0005794;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005654;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0005730;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;Golgi apparatus;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;nucleoplasm;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;nucleolus;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle lumen; 2;5;4;4;4;3;4;3;2;3;3;3;2;5;3;3;4;4;5;5;2;2;3;1;4; GO:0003674;GO:0005488;GO:0030957;GO:0008134;GO:0005515;GO:0030332; molecular_function;binding;Tat protein binding;transcription factor binding;protein binding;cyclin binding; 1;2;5;4;3;4; IPR026134; MyoD family inhibitor/MyoD family inhibitor domain-containing protein; plasma membrane Q9BYD2 39S ribosomal protein L9, mitochondrial OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2 - [RM09_HUMAN] 0.754 1.024 1.384 0.93 0.914 1.395 0.736328125 nan 1.01750547 nan 1.3515625 nan 1.526258206 nan GO:0007005;GO:0044710;GO:0044711;GO:0043043;GO:1901564;GO:1901566;GO:0019538;GO:0006807;GO:0043170;GO:1901576;GO:0044260;GO:0016043;GO:0071840;GO:0032543;GO:0008150;GO:0008152;GO:0044271;GO:0022411;GO:0006518;GO:0044249;GO:0034641;GO:0034645;GO:0043241;GO:0044699;GO:0009987;GO:0043604;GO:0043603;GO:0043933;GO:0032984;GO:0071822;GO:0071704;GO:0010467;GO:0070126;GO:0070124;GO:0070125;GO:0044267;GO:0009058;GO:0009059;GO:0044763;GO:0043624;GO:0006996;GO:0044238;GO:0044237;GO:1902589;GO:0006415;GO:0006414;GO:0006413;GO:0006412; mitochondrion organization;single-organism metabolic process;single-organism biosynthetic process;peptide biosynthetic process;organonitrogen compound metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;cellular component organization or biogenesis;mitochondrial translation;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;cellular component disassembly;peptide metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;protein complex disassembly;single-organism process;cellular process;amide biosynthetic process;cellular amide metabolic process;macromolecular complex subunit organization;macromolecular complex disassembly;protein complex subunit organization;organic substance metabolic process;gene expression;mitochondrial translational termination;mitochondrial translational initiation;mitochondrial translational elongation;cellular protein metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;cellular protein complex disassembly;organelle organization;primary metabolic process;cellular metabolic process;single-organism organelle organization;translational termination;translational elongation;translational initiation;translation; 5;3;4;6;4;5;4;3;4;4;4;3;2;5;1;2;5;4;5;4;4;5;6;2;2;6;5;4;5;5;3;5;6;5;6;5;3;5;3;7;4;3;3;4;7;6;4;6; GO:0031974;GO:0031975;GO:0030529;GO:0016020;GO:0000313;GO:0031967;GO:0031966;GO:0043231;GO:0043233;GO:0044429;GO:0044424;GO:0044464;GO:0044422;GO:1990904;GO:0043232;GO:0043229;GO:0043227;GO:0043226;GO:0005840;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005739;GO:0019866;GO:0005623;GO:0005622;GO:0005743;GO:0005740;GO:0043228;GO:0005759;GO:0032991;GO:0005575;GO:0070013;GO:0005761; membrane-enclosed lumen;envelope;intracellular ribonucleoprotein complex;membrane;organellar ribosome;organelle envelope;mitochondrial membrane;intracellular membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;cell part;organelle part;ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular organelle;membrane-bounded organelle;organelle;ribosome;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;mitochondrion;organelle inner membrane;cell;intracellular;mitochondrial inner membrane;mitochondrial envelope;non-membrane-bounded organelle;mitochondrial matrix;macromolecular complex;cellular_component;intracellular organelle lumen;mitochondrial ribosome; 2;3;4;2;3;4;4;4;3;4;3;2;2;3;4;3;3;2;5;3;4;4;3;5;4;2;3;5;5;3;5;2;1;4;4; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0044822;GO:0003723;GO:0005198;GO:0003735; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;poly(A) RNA binding;RNA binding;structural molecule activity;structural constituent of ribosome; 3;1;2;4;3;6;5;2;3; K02939 map03010; Ribosome; IPR009027;IPR000244;IPR020070; Ribosomal protein L9/RNase H1, N-terminal;Ribosomal protein L9;Ribosomal protein L9, N-terminal; nucleus Hs13899231 542.0 J [J] Translation, ribosomal structure and biogenesis; Q71H61 Immunoglobulin-like domain-containing receptor 2 OS=Homo sapiens OX=9606 GN=ILDR2 PE=2 SV=1 - [ILDR2_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0008104;GO:0060249;GO:0030154;GO:0030072;GO:0042592;GO:0071705;GO:0023052;GO:0015031;GO:0007154;GO:0051179;GO:0007275;GO:0044699;GO:0030073;GO:0042886;GO:0009749;GO:0048869;GO:0046879;GO:0009914;GO:0048513;GO:0065007;GO:0006810;GO:0071702;GO:0065008;GO:0032502;GO:1901700;GO:0032501;GO:0044700;GO:0009306;GO:0009987;GO:0023061;GO:0010817;GO:0044767;GO:0044765;GO:0008150;GO:0032940;GO:0048731;GO:0007267;GO:0042221;GO:0001894;GO:0051234;GO:0010033;GO:1902578;GO:0048872;GO:0009746;GO:0045184;GO:0046903;GO:0033036;GO:0048873;GO:0048871;GO:0044707;GO:0034284;GO:0002790;GO:0050896;GO:0048856;GO:0044763;GO:0015833;GO:0031016;GO:0009743; protein localization;anatomical structure homeostasis;cell differentiation;peptide hormone secretion;homeostatic process;nitrogen compound transport;signaling;protein transport;cell communication;localization;multicellular organism development;single-organism process;insulin secretion;amide transport;response to glucose;cellular developmental process;hormone secretion;hormone transport;animal organ development;biological regulation;transport;organic substance transport;regulation of biological quality;developmental process;response to oxygen-containing compound;multicellular organismal process;single organism signaling;protein secretion;cellular process;signal release;regulation of hormone levels;single-organism developmental process;single-organism transport;biological_process;secretion by cell;system development;cell-cell signaling;response to chemical;tissue homeostasis;establishment of localization;response to organic substance;single-organism localization;homeostasis of number of cells;response to hexose;establishment of protein localization;secretion;macromolecule localization;homeostasis of number of cells within a tissue;multicellular organismal homeostasis;single-multicellular organism process;response to monosaccharide;peptide secretion;response to stimulus;anatomical structure development;single-organism cellular process;peptide transport;pancreas development;response to carbohydrate; 4;5;5;7;4;5;2;5;4;2;4;2;6;5;8;4;6;5;4;2;4;5;3;2;4;2;3;5;2;5;4;3;4;1;4;4;4;3;5;3;4;3;5;7;4;5;3;6;4;3;6;6;2;3;3;6;4;5; GO:0005783;GO:0044464;GO:0005789;GO:0042175;GO:0043229;GO:0005622;GO:0043227;GO:0005737;GO:0044446;GO:0031090;GO:0016021;GO:0016020;GO:0043226;GO:0044432;GO:0031224;GO:0098588;GO:0044424;GO:0012505;GO:0005623;GO:0043231;GO:0005575;GO:0044444;GO:0044425;GO:0044422; endoplasmic reticulum;cell part;endoplasmic reticulum membrane;nuclear outer membrane-endoplasmic reticulum membrane network;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasm;intracellular organelle part;organelle membrane;integral component of membrane;membrane;organelle;endoplasmic reticulum part;intrinsic component of membrane;bounding membrane of organelle;intracellular part;endomembrane system;cell;intracellular membrane-bounded organelle;cellular_component;cytoplasmic part;membrane part;organelle part; 4;2;3;3;3;3;3;4;3;3;4;2;2;4;3;4;3;3;2;4;1;4;2;2; IPR003599;IPR007110;IPR013783;IPR008664; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;LISCH7; extracellular O94911 ATP-binding cassette sub-family A member 8 OS=Homo sapiens OX=9606 GN=ABCA8 PE=1 SV=3 - [ABCA8_HUMAN] 0.959 1.221 0.878 0.84 1.16 1.494 0.785421785 nan 0.724137931 nan 0.719082719 nan 1.287931034 nan GO:0006869;GO:0044699;GO:0055085;GO:0071702;GO:0033036;GO:0044763;GO:0009987;GO:0006810;GO:0044765;GO:0008150;GO:0051234;GO:0010876;GO:0051179;GO:1902578; lipid transport;single-organism process;transmembrane transport;organic substance transport;macromolecule localization;single-organism cellular process;cellular process;transport;single-organism transport;biological_process;establishment of localization;lipid localization;localization;single-organism localization; 5;2;4;5;3;3;2;4;4;1;3;4;2;3; GO:0019866;GO:0005740;GO:0031975;GO:0043229;GO:0071944;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0005743;GO:0031090;GO:0016021;GO:0016020;GO:0044444;GO:0005739;GO:0031224;GO:0031967;GO:0031966;GO:0005886;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044429;GO:0044424;GO:0044425;GO:0044422; organelle inner membrane;mitochondrial envelope;envelope;intracellular organelle;cell periphery;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;mitochondrial inner membrane;organelle membrane;integral component of membrane;membrane;cytoplasmic part;mitochondrion;intrinsic component of membrane;organelle envelope;mitochondrial membrane;plasma membrane;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;mitochondrial part;intracellular part;membrane part;organelle part; 4;5;3;3;3;3;2;4;3;5;3;4;2;4;5;3;4;4;3;4;2;2;3;1;4;3;2;2; GO:0043168;GO:0000166;GO:0035639;GO:1901363;GO:0032549;GO:0032553;GO:0003674;GO:0005488;GO:0016887;GO:0005524;GO:0001883;GO:0043167;GO:0001882;GO:0042626;GO:0016820;GO:0042623;GO:0032555;GO:0015399;GO:0017076;GO:0022804;GO:0016787;GO:0005215;GO:0017111;GO:0036094;GO:0003824;GO:0016818;GO:0030554;GO:0097367;GO:0097159;GO:0043492;GO:0016817;GO:0016462;GO:0022857;GO:0032550;GO:0032559;GO:0015405;GO:1901265; anion binding;nucleotide binding;purine ribonucleoside triphosphate binding;heterocyclic compound binding;ribonucleoside binding;ribonucleotide binding;molecular_function;binding;ATPase activity;ATP binding;purine nucleoside binding;ion binding;nucleoside binding;ATPase activity, coupled to transmembrane movement of substances;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;ATPase activity, coupled;purine ribonucleotide binding;primary active transmembrane transporter activity;purine nucleotide binding;active transmembrane transporter activity;hydrolase activity;transporter activity;nucleoside-triphosphatase activity;small molecule binding;catalytic activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;adenyl nucleotide binding;carbohydrate derivative binding;organic cyclic compound binding;ATPase activity, coupled to movement of substances;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;transmembrane transporter activity;purine ribonucleoside binding;adenyl ribonucleotide binding;P-P-bond-hydrolysis-driven transmembrane transporter activity;nucleoside phosphate binding; 4;4;5;3;5;4;1;2;8;6;5;3;4;6;5;9;5;5;5;4;3;2;7;3;2;5;6;3;3;10;4;6;3;6;6;6;4; K05650 map02010; ABC transporters; IPR003593;IPR026082;IPR027417;IPR003439; AAA+ ATPase domain;ABC transporter A, ABCA;P-loop containing nucleoside triphosphate hydrolase;ABC transporter-like; plasma membrane Hs6005701 3270.0 IR [I] Lipid transport and metabolism;[R] General function prediction only; P17301 Integrin alpha-2 OS=Homo sapiens OX=9606 GN=ITGA2 PE=1 SV=1 - [ITA2_HUMAN] 0.442 0.708 2.391 0.53 0.698 1.263 0.624293785 nan 0.759312321 nan 3.377118644 nan 1.809455587 nan GO:0007599;GO:0007409;GO:0051049;GO:0007596;GO:0006909;GO:0051716;GO:0000003;GO:0030855;GO:0048583;GO:0097485;GO:0065009;GO:0010634;GO:0010631;GO:0009605;GO:0034284;GO:0019538;GO:0009893;GO:0009891;GO:0014812;GO:0031175;GO:0050789;GO:0032092;GO:0000904;GO:0000902;GO:0051345;GO:0010646;GO:0002687;GO:0002684;GO:0002685;GO:0002682;GO:0051971;GO:0043412;GO:0035303;GO:0035304;GO:0035307;GO:0035306;GO:0010557;GO:0010556;GO:0043393;GO:0097305;GO:0097306;GO:0034250;GO:0007498;GO:0051128;GO:0014075;GO:1901566;GO:0033273;GO:0031349;GO:0070365;GO:0008284;GO:0050974;GO:0050878;GO:0008283;GO:0050877;GO:0006970;GO:0045216;GO:0044253;GO:0034329;GO:0050906;GO:0031646;GO:0030030;GO:0050900;GO:0001889;GO:0007275;GO:0032355;GO:0010632;GO:0033993;GO:2000112;GO:0043062;GO:0048598;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0090257;GO:0030100;GO:0006518;GO:0040011;GO:0051272;GO:0040012;GO:0048858;GO:0040017;GO:0048856;GO:0006796;GO:0006793;GO:0014850;GO:0006412;GO:0010694;GO:0048522;GO:0008104;GO:0007160;GO:0003012;GO:0007165;GO:0007166;GO:0031344;GO:0031347;GO:0032103;GO:0044710;GO:0044711;GO:0050966;GO:0045785;GO:0050727;GO:0044093;GO:0033036;GO:0006935;GO:0006936;GO:0006937;GO:0006939;GO:0010033;GO:0051704;GO:0009790;GO:0031667;GO:0032967;GO:0061008;GO:0023051;GO:0006807;GO:0001667;GO:0044267;GO:0009653;GO:0044260;GO:0043085;GO:0009887;GO:0050790;GO:0009889;GO:0009888;GO:0050794;GO:0051239;GO:0051234;GO:0051336;GO:0006897;GO:0050896;GO:0010714;GO:0010712;GO:2000145;GO:2000147;GO:0031346;GO:0051969;GO:0010562;GO:0033591;GO:0032964;GO:0032965;GO:0007045;GO:0007044;GO:0070887;GO:0032963;GO:0044699;GO:0050766;GO:0050764;GO:0044057;GO:0051240;GO:0051246;GO:0051247;GO:0031399;GO:1903034;GO:1903036;GO:1901700;GO:1901701;GO:0071392;GO:0071391;GO:0071396;GO:0034248;GO:0051270;GO:0060100;GO:0090132;GO:0090130;GO:0042493;GO:0010324;GO:0048731;GO:0048732;GO:0034333;GO:0034332;GO:0034330;GO:0048041;GO:0010692;GO:0043588;GO:0043589;GO:0045933;GO:0030182;GO:0006417;GO:0043627;GO:0050918;GO:0022008;GO:0070482;GO:0009628;GO:0009743;GO:0044237;GO:0044236;GO:0045807;GO:0019226;GO:0019220;GO:0019222;GO:0006470;GO:0048584;GO:0048468;GO:0045987;GO:0071840;GO:0048869;GO:0048513;GO:0048518;GO:0042127;GO:0031589;GO:0007600;GO:0045184;GO:0003008;GO:0044700;GO:0044703;GO:0016477;GO:1901564;GO:0016192;GO:0044707;GO:0044706;GO:0010243;GO:0002376;GO:0033002;GO:0007565;GO:0022607;GO:0071107;GO:0071260;GO:0051101;GO:0006929;GO:0006928;GO:0051674;GO:0043388;GO:0071214;GO:0030879;GO:0048646;GO:0061564;GO:0050954;GO:0006810;GO:0006950;GO:0050817;GO:0006954;GO:0006952;GO:0051606;GO:0036293;GO:0080134;GO:0031401;GO:0007369;GO:0010921;GO:0030155;GO:0030154;GO:1905155;GO:1905153;GO:0001707;GO:0001704;GO:0032270;GO:0031326;GO:0032502;GO:0071496;GO:0048332;GO:0048333;GO:0009987;GO:0060627;GO:0032870;GO:0044271;GO:0032879;GO:0071407;GO:0048545;GO:0071383;GO:0051050;GO:0032989;GO:0032101;GO:0071704;GO:0071310;GO:0048812;GO:0048729;GO:0030335;GO:0030334;GO:0007584;GO:0006911;GO:0051174;GO:0009058;GO:0009059;GO:0051171;GO:0051173;GO:0051179;GO:1902578;GO:0080090;GO:0061024;GO:0050926;GO:0050927;GO:0050920;GO:0050921;GO:0044259;GO:0010604;GO:0042330;GO:0010608;GO:0043043;GO:0009611;GO:0009612;GO:0010922;GO:0060255;GO:0014823;GO:0060099;GO:0048870;GO:0030198;GO:0033627;GO:0048667;GO:0038065;GO:1901576;GO:0045937;GO:0016043;GO:0065007;GO:0014070;GO:0019233;GO:0065008;GO:0051130;GO:0009719;GO:0042060;GO:0036211;GO:0008150;GO:0008152;GO:0022414;GO:0031644;GO:1901698;GO:0048659;GO:0035637;GO:0016311;GO:0023056;GO:0006940;GO:0034641;GO:0023052;GO:0045727;GO:0034645;GO:0042221;GO:0007411;GO:0010647;GO:0001666;GO:0044246;GO:0022610;GO:0044238;GO:0032501;GO:0060429;GO:0001101;GO:0043604;GO:0032268;GO:0043603;GO:0009725;GO:0051099;GO:0051098;GO:0043170;GO:0050729;GO:0010628;GO:0071495;GO:0009991;GO:0031328;GO:0014911;GO:0014910;GO:0031325;GO:0031323;GO:0014909;GO:0050982;GO:0010467;GO:0010468;GO:0048666;GO:0009581;GO:0009582;GO:0048660;GO:0048661;GO:0007229;GO:0007155;GO:0007154;GO:0048699;GO:0032990;GO:0007399;GO:0044085;GO:0033343;GO:0033341;GO:0044249;GO:0006971; hemostasis;axonogenesis;regulation of transport;blood coagulation;phagocytosis;cellular response to stimulus;reproduction;epithelial cell differentiation;regulation of response to stimulus;neuron projection guidance;regulation of molecular function;positive regulation of epithelial cell migration;epithelial cell migration;response to external stimulus;response to monosaccharide;protein metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;muscle cell migration;neuron projection development;regulation of biological process;positive regulation of protein binding;cell morphogenesis involved in differentiation;cell morphogenesis;positive regulation of hydrolase activity;regulation of cell communication;positive regulation of leukocyte migration;positive regulation of immune system process;regulation of leukocyte migration;regulation of immune system process;positive regulation of transmission of nerve impulse;macromolecule modification;regulation of dephosphorylation;regulation of protein dephosphorylation;positive regulation of protein dephosphorylation;positive regulation of dephosphorylation;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;regulation of protein binding;response to alcohol;cellular response to alcohol;positive regulation of cellular amide metabolic process;mesoderm development;regulation of cellular component organization;response to amine;organonitrogen compound biosynthetic process;response to vitamin;positive regulation of defense response;hepatocyte differentiation;positive regulation of cell proliferation;detection of mechanical stimulus involved in sensory perception;regulation of body fluid levels;cell proliferation;neurological system process;response to osmotic stress;cell-cell junction organization;positive regulation of multicellular organismal metabolic process;cell junction assembly;detection of stimulus involved in sensory perception;positive regulation of neurological system process;cell projection organization;leukocyte migration;liver development;multicellular organism development;response to estradiol;regulation of epithelial cell migration;response to lipid;regulation of cellular macromolecule biosynthetic process;extracellular structure organization;embryonic morphogenesis;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;regulation of muscle system process;regulation of endocytosis;peptide metabolic process;locomotion;positive regulation of cellular component movement;regulation of locomotion;cell projection morphogenesis;positive regulation of locomotion;anatomical structure development;phosphate-containing compound metabolic process;phosphorus metabolic process;response to muscle activity;translation;positive regulation of alkaline phosphatase activity;positive regulation of cellular process;protein localization;cell-matrix adhesion;muscle system process;signal transduction;cell surface receptor signaling pathway;regulation of cell projection organization;regulation of defense response;positive regulation of response to external stimulus;single-organism metabolic process;single-organism biosynthetic process;detection of mechanical stimulus involved in sensory perception of pain;positive regulation of cell adhesion;regulation of inflammatory response;positive regulation of molecular function;macromolecule localization;chemotaxis;muscle contraction;regulation of muscle contraction;smooth muscle contraction;response to organic substance;multi-organism process;embryo development;response to nutrient levels;positive regulation of collagen biosynthetic process;hepaticobiliary system development;regulation of signaling;nitrogen compound metabolic process;ameboidal-type cell migration;cellular protein metabolic process;anatomical structure morphogenesis;cellular macromolecule metabolic process;positive regulation of catalytic activity;organ morphogenesis;regulation of catalytic activity;regulation of biosynthetic process;tissue development;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;endocytosis;response to stimulus;positive regulation of collagen metabolic process;regulation of collagen metabolic process;regulation of cell motility;positive regulation of cell motility;positive regulation of cell projection organization;regulation of transmission of nerve impulse;positive regulation of phosphorus metabolic process;response to L-ascorbic acid;collagen biosynthetic process;regulation of collagen biosynthetic process;cell-substrate adherens junction assembly;cell-substrate junction assembly;cellular response to chemical stimulus;collagen metabolic process;single-organism process;positive regulation of phagocytosis;regulation of phagocytosis;regulation of system process;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of protein modification process;regulation of response to wounding;positive regulation of response to wounding;response to oxygen-containing compound;cellular response to oxygen-containing compound;cellular response to estradiol stimulus;cellular response to estrogen stimulus;cellular response to lipid;regulation of cellular amide metabolic process;regulation of cellular component movement;positive regulation of phagocytosis, engulfment;epithelium migration;tissue migration;response to drug;membrane invagination;system development;gland development;adherens junction assembly;adherens junction organization;cell junction organization;focal adhesion assembly;regulation of alkaline phosphatase activity;skin development;skin morphogenesis;positive regulation of muscle contraction;neuron differentiation;regulation of translation;response to estrogen;positive chemotaxis;neurogenesis;response to oxygen levels;response to abiotic stimulus;response to carbohydrate;cellular metabolic process;multicellular organism metabolic process;positive regulation of endocytosis;transmission of nerve impulse;regulation of phosphate metabolic process;regulation of metabolic process;protein dephosphorylation;positive regulation of response to stimulus;cell development;positive regulation of smooth muscle contraction;cellular component organization or biogenesis;cellular developmental process;animal organ development;positive regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;sensory perception;establishment of protein localization;system process;single organism signaling;multi-organism reproductive process;cell migration;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;multi-multicellular organism process;response to organonitrogen compound;immune system process;muscle cell proliferation;female pregnancy;cellular component assembly;response to parathyroid hormone;cellular response to mechanical stimulus;regulation of DNA binding;substrate-dependent cell migration;movement of cell or subcellular component;localization of cell;positive regulation of DNA binding;cellular response to abiotic stimulus;mammary gland development;anatomical structure formation involved in morphogenesis;axon development;sensory perception of mechanical stimulus;transport;response to stress;coagulation;inflammatory response;defense response;detection of stimulus;response to decreased oxygen levels;regulation of response to stress;positive regulation of protein modification process;gastrulation;regulation of phosphatase activity;regulation of cell adhesion;cell differentiation;positive regulation of membrane invagination;regulation of membrane invagination;mesoderm formation;formation of primary germ layer;positive regulation of cellular protein metabolic process;regulation of cellular biosynthetic process;developmental process;cellular response to external stimulus;mesoderm morphogenesis;mesodermal cell differentiation;cellular process;regulation of vesicle-mediated transport;cellular response to hormone stimulus;cellular nitrogen compound biosynthetic process;regulation of localization;cellular response to organic cyclic compound;response to steroid hormone;cellular response to steroid hormone stimulus;positive regulation of transport;cellular component morphogenesis;regulation of response to external stimulus;organic substance metabolic process;cellular response to organic substance;neuron projection morphogenesis;tissue morphogenesis;positive regulation of cell migration;regulation of cell migration;response to nutrient;phagocytosis, engulfment;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;localization;single-organism localization;regulation of primary metabolic process;membrane organization;regulation of positive chemotaxis;positive regulation of positive chemotaxis;regulation of chemotaxis;positive regulation of chemotaxis;multicellular organismal macromolecule metabolic process;positive regulation of macromolecule metabolic process;taxis;posttranscriptional regulation of gene expression;peptide biosynthetic process;response to wounding;response to mechanical stimulus;positive regulation of phosphatase activity;regulation of macromolecule metabolic process;response to activity;regulation of phagocytosis, engulfment;cell motility;extracellular matrix organization;cell adhesion mediated by integrin;cell morphogenesis involved in neuron differentiation;collagen-activated signaling pathway;organic substance biosynthetic process;positive regulation of phosphate metabolic process;cellular component organization;biological regulation;response to organic cyclic compound;sensory perception of pain;regulation of biological quality;positive regulation of cellular component organization;response to endogenous stimulus;wound healing;protein modification process;biological_process;metabolic process;reproductive process;regulation of neurological system process;response to nitrogen compound;smooth muscle cell proliferation;multicellular organismal signaling;dephosphorylation;positive regulation of signaling;regulation of smooth muscle contraction;cellular nitrogen compound metabolic process;signaling;positive regulation of translation;cellular macromolecule biosynthetic process;response to chemical;axon guidance;positive regulation of cell communication;response to hypoxia;regulation of multicellular organismal metabolic process;biological adhesion;primary metabolic process;multicellular organismal process;epithelium development;response to acid chemical;amide biosynthetic process;regulation of cellular protein metabolic process;cellular amide metabolic process;response to hormone;positive regulation of binding;regulation of binding;macromolecule metabolic process;positive regulation of inflammatory response;positive regulation of gene expression;cellular response to endogenous stimulus;response to extracellular stimulus;positive regulation of cellular biosynthetic process;positive regulation of smooth muscle cell migration;regulation of smooth muscle cell migration;positive regulation of cellular metabolic process;regulation of cellular metabolic process;smooth muscle cell migration;detection of mechanical stimulus;gene expression;regulation of gene expression;neuron development;detection of external stimulus;detection of abiotic stimulus;regulation of smooth muscle cell proliferation;positive regulation of smooth muscle cell proliferation;integrin-mediated signaling pathway;cell adhesion;cell communication;generation of neurons;cell part morphogenesis;nervous system development;cellular component biogenesis;positive regulation of collagen binding;regulation of collagen binding;cellular biosynthetic process;hypotonic response; 5;7;4;5;5;3;2;6;3;5;3;4;6;3;6;4;3;4;5;5;2;6;5;5;6;4;4;3;4;3;4;5;7;7;7;7;5;5;5;5;6;5;5;4;5;5;5;4;6;4;5;4;3;4;4;5;4;5;4;4;4;3;5;4;6;4;5;6;4;4;6;3;4;3;5;5;5;2;4;3;5;3;3;5;4;4;6;8;3;4;5;4;4;5;5;5;4;3;4;6;4;5;4;3;4;5;6;6;4;2;5;5;6;5;3;3;5;5;3;4;5;4;4;4;4;3;3;3;5;6;2;5;5;4;4;5;4;5;5;5;6;7;6;4;6;2;5;6;4;3;5;5;6;5;4;4;5;7;7;6;5;4;6;5;4;4;5;4;4;6;6;4;6;7;5;5;4;6;6;6;5;6;4;3;5;3;4;4;5;6;3;7;3;4;5;2;4;4;2;4;4;5;4;3;3;3;4;4;5;3;3;4;2;4;4;4;5;5;5;5;4;3;6;4;5;3;6;6;4;3;4;5;4;3;5;4;6;5;6;4;5;5;5;5;4;5;5;2;4;5;6;2;4;5;5;3;6;5;6;3;4;4;3;5;6;4;5;5;4;6;5;3;5;4;4;2;3;4;4;5;5;4;4;5;4;3;6;6;4;4;7;4;3;6;3;5;4;6;6;4;6;3;2;5;6;3;4;3;5;5;1;2;2;5;4;5;4;6;3;7;4;2;6;5;3;6;4;4;4;2;3;2;5;4;6;5;5;4;5;4;4;5;5;4;4;5;6;6;4;4;6;5;5;5;5;4;4;5;5;6;3;4;7;5;5;3;7;6;4;5; GO:0043679;GO:0044424;GO:0044425;GO:0009897;GO:0030054;GO:0070161;GO:0031226;GO:0031224;GO:0045178;GO:0005912;GO:0044463;GO:0044464;GO:0071944;GO:0016021;GO:0016020;GO:0042995;GO:0043234;GO:0043235;GO:0043231;GO:0005924;GO:0005925;GO:0034666;GO:0098636;GO:0044306;GO:0030055;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0008305;GO:0044444;GO:0005737;GO:0005634;GO:0043005;GO:0009986;GO:0098552;GO:0030424;GO:0048471;GO:0033267;GO:0044459;GO:0005623;GO:0005575;GO:0098802;GO:0097458;GO:0005887;GO:0005886;GO:0032991;GO:0098797;GO:0098796; axon terminus;intracellular part;membrane part;external side of plasma membrane;cell junction;anchoring junction;intrinsic component of plasma membrane;intrinsic component of membrane;basal part of cell;adherens junction;cell projection part;cell part;cell periphery;integral component of membrane;membrane;cell projection;protein complex;receptor complex;intracellular membrane-bounded organelle;cell-substrate adherens junction;focal adhesion;integrin alpha2-beta1 complex;protein complex involved in cell adhesion;neuron projection terminus;cell-substrate junction;intracellular organelle;intracellular;membrane-bounded organelle;organelle;integrin complex;cytoplasmic part;cytoplasm;nucleus;neuron projection;cell surface;side of membrane;axon;perinuclear region of cytoplasm;axon part;plasma membrane part;cell;cellular_component;plasma membrane receptor complex;neuron part;integral component of plasma membrane;plasma membrane;macromolecular complex;plasma membrane protein complex;membrane protein complex; 5;3;2;4;2;3;4;3;3;4;3;2;3;4;2;3;3;4;4;4;5;6;4;4;3;3;3;3;2;5;4;4;5;4;3;3;5;5;4;3;2;1;4;3;4;3;2;4;3; GO:0001618;GO:0005488;GO:0003674;GO:0099600;GO:0098634;GO:0098631;GO:0098639;GO:0032403;GO:0005515;GO:0005518;GO:0060089;GO:0046872;GO:0044877;GO:0043169;GO:0043167;GO:0004888;GO:0038064;GO:0038023;GO:0004872;GO:0004871; virus receptor activity;binding;molecular_function;transmembrane receptor activity;protein binding involved in cell-matrix adhesion;protein binding involved in cell adhesion;collagen binding involved in cell-matrix adhesion;protein complex binding;protein binding;collagen binding;molecular transducer activity;metal ion binding;macromolecular complex binding;cation binding;ion binding;transmembrane signaling receptor activity;collagen receptor activity;signaling receptor activity;receptor activity;signal transducer activity; 4;2;1;4;5;4;6;4;3;5;2;5;3;4;3;4;5;3;3;2; K06481 map04145;map04151;map04510;map04512;map04611;map04640;map04810;map05200;map05205;map05222;map05410;map05412;map05414; Phagosome;PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Platelet activation;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Pathways in cancer;Proteoglycans in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy; IPR002035;IPR013519;IPR013517;IPR013649;IPR018184;IPR000413;IPR032695; von Willebrand factor, type A;Integrin alpha beta-propellor;FG-GAP repeat;Integrin alpha-2;Integrin alpha chain, C-terminal cytoplasmic region, conserved site;Integrin alpha chain;Integrin domain; plasma membrane Hs4504743 2446.0 W [W] Extracellular structures; Q96JG6 Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3 - [VPS50_HUMAN] 1.03 1.307 0.907 0.858 1.252 0.446 0.788064269 nan 0.685303514 nan 0.693955624 nan 0.356230032 nan GO:0033036;GO:0008104;GO:0044699;GO:0051234;GO:0071702;GO:0051641;GO:0006810;GO:0045184;GO:0015031;GO:0044765;GO:0007034;GO:0051649;GO:0051179;GO:1902578;GO:0016197;GO:1902582;GO:0046907;GO:0032456;GO:0008150;GO:0016192; macromolecule localization;protein localization;single-organism process;establishment of localization;organic substance transport;cellular localization;transport;establishment of protein localization;protein transport;single-organism transport;vacuolar transport;establishment of localization in cell;localization;single-organism localization;endosomal transport;single-organism intracellular transport;intracellular transport;endocytic recycling;biological_process;vesicle-mediated transport; 3;4;2;3;5;3;4;4;5;4;6;4;2;3;7;5;5;6;1;5; GO:0055037;GO:1990745;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070062;GO:0005773;GO:0016020;GO:0044437;GO:0043234;GO:0044440;GO:0012505;GO:0032991;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0005768;GO:0044421;GO:0044422; recycling endosome;EARP complex;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;extracellular exosome;vacuole;membrane;vacuolar part;protein complex;endosomal part;endomembrane system;macromolecular complex;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;endosome;extracellular region part;organelle part; 5;4;3;3;2;4;3;4;5;2;4;3;5;3;2;3;4;3;4;2;2;3;1;4;2;3;4;2;2; K23288 IPR019514;IPR019515; Protein of unknown function DUF2451, C-terminal;Vacuolar protein sorting-associated protein 54, N-terminal; nucleus Hs8923108_1 734.0 S [S] Function unknown; Q02246 Contactin-2 OS=Homo sapiens OX=9606 GN=CNTN2 PE=1 SV=1 - [CNTN2_HUMAN] 0.908 0.711 1.494 0.865 0.841 1.84 1.277074543 nan 1.028537455 nan 2.101265823 nan 2.187871581 nan GO:0044238;GO:0080090;GO:0019222;GO:0008104;GO:0048584;GO:0048468;GO:0048469;GO:0007610;GO:0007611;GO:0007160;GO:0061024;GO:0008277;GO:0060322;GO:0007165;GO:0007166;GO:0045745;GO:0031344;GO:0071840;GO:0021830;GO:0051716;GO:0010604;GO:0042330;GO:0071704;GO:0048869;GO:0010467;GO:0045664;GO:0021853;GO:0009967;GO:0010721;GO:0048518;GO:0048519;GO:0033036;GO:0016192;GO:0035588;GO:0031589;GO:0006935;GO:0060255;GO:0007612;GO:0021879;GO:0007628;GO:0045184;GO:0045163;GO:0030162;GO:0008366;GO:0010975;GO:0031133;GO:0097485;GO:0022029;GO:0003008;GO:0044700;GO:0016477;GO:0009605;GO:0044707;GO:0022010;GO:0019538;GO:0044708;GO:0048870;GO:0007154;GO:0098916;GO:0021843;GO:0032536;GO:0032535;GO:0021537;GO:0021885;GO:0048710;GO:0021826;GO:0097090;GO:0021884;GO:1904936;GO:0006928;GO:0048167;GO:0051674;GO:0031175;GO:0021700;GO:0050789;GO:0007186;GO:0044267;GO:0000904;GO:0042552;GO:0000902;GO:0044260;GO:0014013;GO:0010646;GO:0016043;GO:0090066;GO:0060167;GO:0065007;GO:0065008;GO:0099612;GO:0007626;GO:0061564;GO:0060168;GO:0050793;GO:0006810;GO:0048709;GO:0042063;GO:0048708;GO:0051128;GO:0044802;GO:0051239;GO:0045862;GO:0014003;GO:0021895;GO:0050794;GO:0021892;GO:0070613;GO:0097154;GO:0007420;GO:0051604;GO:0045161;GO:0050896;GO:0006898;GO:0050890;GO:0044765;GO:0071205;GO:0009966;GO:0051961;GO:0051960;GO:1903319;GO:0071206;GO:0001973;GO:0008150;GO:1903317;GO:0099536;GO:0099537;GO:0022604;GO:0050808;GO:0008152;GO:0050803;GO:0008344;GO:0030154;GO:0050804;GO:0023056;GO:0007267;GO:0023052;GO:0050768;GO:0010001;GO:0023051;GO:0007411;GO:0010647;GO:0009653;GO:0021894;GO:0044699;GO:0007417;GO:0009893;GO:0050767;GO:0051234;GO:0006897;GO:0021782;GO:0007413;GO:0051241;GO:0051246;GO:0051247;GO:0060284;GO:0044710;GO:0048513;GO:0032270;GO:0021954;GO:0022610;GO:0021953;GO:0043112;GO:0032502;GO:0040011;GO:0032501;GO:0032291;GO:0050877;GO:0009987;GO:0010769;GO:0048583;GO:0008038;GO:0048168;GO:0045596;GO:0045595;GO:0007409;GO:0006508;GO:0016485;GO:0048858;GO:0051093;GO:0032268;GO:0031623;GO:0043170;GO:0048731;GO:0008037;GO:0042551;GO:0050770;GO:0030030;GO:0031325;GO:0031323;GO:0035587;GO:0007272;GO:0007275;GO:0045685;GO:0010628;GO:0032989;GO:0001764;GO:0048812;GO:0022603;GO:0045665;GO:0030900;GO:0010954;GO:0021872;GO:0010468;GO:0048666;GO:0048667;GO:0030182;GO:0034613;GO:0044767;GO:0000226;GO:0044763;GO:0007268;GO:0007155;GO:0042221;GO:0022008;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0030534;GO:0048699;GO:0007017;GO:0007010;GO:0032990;GO:0007399;GO:0048856;GO:0044237;GO:0090659;GO:1902589;GO:0070727;GO:2000026;GO:0048522;GO:0048523; primary metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein localization;positive regulation of response to stimulus;cell development;cell maturation;behavior;learning or memory;cell-matrix adhesion;membrane organization;regulation of G-protein coupled receptor protein signaling pathway;head development;signal transduction;cell surface receptor signaling pathway;positive regulation of G-protein coupled receptor protein signaling pathway;regulation of cell projection organization;cellular component organization or biogenesis;interneuron migration from the subpallium to the cortex;cellular response to stimulus;positive regulation of macromolecule metabolic process;taxis;organic substance metabolic process;cellular developmental process;gene expression;regulation of neuron differentiation;cerebral cortex GABAergic interneuron migration;positive regulation of signal transduction;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;macromolecule localization;vesicle-mediated transport;G-protein coupled purinergic receptor signaling pathway;cell-substrate adhesion;chemotaxis;regulation of macromolecule metabolic process;learning;forebrain neuron differentiation;adult walking behavior;establishment of protein localization;clustering of voltage-gated potassium channels;regulation of proteolysis;axon ensheathment;regulation of neuron projection development;regulation of axon diameter;neuron projection guidance;telencephalon cell migration;system process;single organism signaling;cell migration;response to external stimulus;single-multicellular organism process;central nervous system myelination;protein metabolic process;single-organism behavior;cell motility;cell communication;anterograde trans-synaptic signaling;substrate-independent telencephalic tangential interneuron migration;regulation of cell projection size;regulation of cellular component size;telencephalon development;forebrain cell migration;regulation of astrocyte differentiation;substrate-independent telencephalic tangential migration;presynaptic membrane organization;forebrain neuron development;interneuron migration;movement of cell or subcellular component;regulation of synaptic plasticity;localization of cell;neuron projection development;developmental maturation;regulation of biological process;G-protein coupled receptor signaling pathway;cellular protein metabolic process;cell morphogenesis involved in differentiation;myelination;cell morphogenesis;cellular macromolecule metabolic process;regulation of gliogenesis;regulation of cell communication;cellular component organization;regulation of anatomical structure size;regulation of adenosine receptor signaling pathway;biological regulation;regulation of biological quality;protein localization to axon;locomotory behavior;axon development;positive regulation of adenosine receptor signaling pathway;regulation of developmental process;transport;oligodendrocyte differentiation;gliogenesis;astrocyte differentiation;regulation of cellular component organization;single-organism membrane organization;regulation of multicellular organismal process;positive regulation of proteolysis;oligodendrocyte development;cerebral cortex neuron differentiation;regulation of cellular process;cerebral cortex GABAergic interneuron differentiation;regulation of protein processing;GABAergic neuron differentiation;brain development;protein maturation;neuronal ion channel clustering;response to stimulus;receptor-mediated endocytosis;cognition;single-organism transport;protein localization to juxtaparanode region of axon;regulation of signal transduction;negative regulation of nervous system development;regulation of nervous system development;positive regulation of protein maturation;establishment of protein localization to juxtaparanode region of axon;adenosine receptor signaling pathway;biological_process;regulation of protein maturation;synaptic signaling;trans-synaptic signaling;regulation of cell morphogenesis;synapse organization;metabolic process;regulation of synapse structure or activity;adult locomotory behavior;cell differentiation;modulation of synaptic transmission;positive regulation of signaling;cell-cell signaling;signaling;negative regulation of neurogenesis;glial cell differentiation;regulation of signaling;axon guidance;positive regulation of cell communication;anatomical structure morphogenesis;cerebral cortex GABAergic interneuron development;single-organism process;central nervous system development;positive regulation of metabolic process;regulation of neurogenesis;establishment of localization;endocytosis;glial cell development;axonal fasciculation;negative regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;regulation of cell development;single-organism metabolic process;animal organ development;positive regulation of cellular protein metabolic process;central nervous system neuron development;biological adhesion;central nervous system neuron differentiation;receptor metabolic process;developmental process;locomotion;multicellular organismal process;axon ensheathment in central nervous system;neurological system process;cellular process;regulation of cell morphogenesis involved in differentiation;regulation of response to stimulus;neuron recognition;regulation of neuronal synaptic plasticity;negative regulation of cell differentiation;regulation of cell differentiation;axonogenesis;proteolysis;protein processing;cell projection morphogenesis;negative regulation of developmental process;regulation of cellular protein metabolic process;receptor internalization;macromolecule metabolic process;system development;cell recognition;neuron maturation;regulation of axonogenesis;cell projection organization;positive regulation of cellular metabolic process;regulation of cellular metabolic process;purinergic receptor signaling pathway;ensheathment of neurons;multicellular organism development;regulation of glial cell differentiation;positive regulation of gene expression;cellular component morphogenesis;neuron migration;neuron projection morphogenesis;regulation of anatomical structure morphogenesis;negative regulation of neuron differentiation;forebrain development;positive regulation of protein processing;forebrain generation of neurons;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;neuron differentiation;cellular protein localization;single-organism developmental process;microtubule cytoskeleton organization;single-organism cellular process;synaptic transmission;cell adhesion;response to chemical;neurogenesis;localization;single-organism localization;cellular localization;organelle organization;adult behavior;generation of neurons;microtubule-based process;cytoskeleton organization;cell part morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;walking behavior;single-organism organelle organization;cellular macromolecule localization;regulation of multicellular organismal development;positive regulation of cellular process;negative regulation of cellular process; 3;4;3;4;3;4;5;2;4;5;4;5;4;4;5;5;5;2;8;3;4;3;3;4;5;7;7;4;5;2;2;3;5;6;4;4;4;5;6;5;4;6;6;5;6;6;5;5;3;3;4;3;3;7;4;3;3;4;7;7;5;4;4;5;7;6;5;7;6;4;5;3;5;4;2;5;5;5;6;5;4;7;4;3;4;6;2;3;5;3;6;6;3;4;6;7;6;4;4;3;6;6;5;3;6;7;7;4;5;5;2;7;5;4;6;4;4;5;6;5;7;1;6;5;6;5;4;2;4;4;5;4;3;4;2;5;6;3;6;4;3;7;2;5;3;6;3;6;5;6;3;5;5;5;3;4;5;6;2;6;5;2;2;2;6;4;2;6;3;5;6;4;4;7;5;6;5;3;5;4;4;4;4;6;7;4;4;4;6;4;4;7;5;4;5;6;4;6;4;7;5;5;5;6;6;5;3;5;3;8;3;3;6;2;3;3;4;4;7;4;5;5;5;3;3;4;4;4;4;3;3; GO:0042995;GO:0043209;GO:0016021;GO:0016020;GO:0031225;GO:1902495;GO:0044297;GO:0008076;GO:0043234;GO:0044425;GO:0031226;GO:0031224;GO:0005886;GO:0043025;GO:1990351;GO:0033267;GO:0033268;GO:0098797;GO:0043005;GO:0044459;GO:0009986;GO:0032991;GO:0044463;GO:0044464;GO:0005623;GO:0034702;GO:0034705;GO:0034703;GO:0071944;GO:0045202;GO:0044304;GO:0044224;GO:0097458;GO:0030424;GO:0005887;GO:0005575;GO:0098796;GO:0036477; cell projection;myelin sheath;integral component of membrane;membrane;anchored component of membrane;transmembrane transporter complex;cell body;voltage-gated potassium channel complex;protein complex;membrane part;intrinsic component of plasma membrane;intrinsic component of membrane;plasma membrane;neuronal cell body;transporter complex;axon part;node of Ranvier;plasma membrane protein complex;neuron projection;plasma membrane part;cell surface;macromolecular complex;cell projection part;cell part;cell;ion channel complex;potassium channel complex;cation channel complex;cell periphery;synapse;main axon;juxtaparanode region of axon;neuron part;axon;integral component of plasma membrane;cellular_component;membrane protein complex;somatodendritic compartment; 3;3;4;2;4;4;3;5;3;2;4;3;3;4;4;4;5;4;4;3;3;2;3;2;2;5;7;6;3;2;5;5;3;5;4;1;3;4; GO:0003674;GO:0005488;GO:0042802;GO:0005515;GO:0030246; molecular_function;binding;identical protein binding;protein binding;carbohydrate binding; 1;2;4;3;3; K06760 map04514; Cell adhesion molecules (CAMs); IPR003599;IPR007110;IPR013783;IPR013098;IPR003598;IPR003961;IPR032991; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin I-set;Immunoglobulin subtype 2;Fibronectin type III;Contactin-1/2; extracellular Hs4827022 2148.0 T [T] Signal transduction mechanisms; A0A0B4J1Y8 Immunoglobulin lambda variable 9-49 OS=Homo sapiens OX=9606 GN=IGLV9-49 PE=1 SV=1 - [LV949_HUMAN] 0.803 1.094 1.253 0.776 1.056 1.247 0.734003656 0.50939249 0.734848485 0.395640233 1.145338208 0.85872458 1.180871212 0.129444012 IPR003599;IPR013106;IPR013783;IPR003598;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin subtype 2;Immunoglobulin-like domain; extracellular A0A0B4J1Y9 Immunoglobulin heavy variable 3-72 OS=Homo sapiens OX=9606 GN=IGHV3-72 PE=3 SV=1 - [HV372_HUMAN] 1.047 1.032 1.002 0.99 1.033 1.194 1.014534884 0.248359924 0.958373669 0.302862744 0.970930233 0.598568514 1.155856728 0.151243915 IPR013106;IPR013783;IPR007110; Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q99453 Paired mesoderm homeobox protein 2B OS=Homo sapiens OX=9606 GN=PHOX2B PE=1 SV=2 - [PHX2B_HUMAN] 0.97 1.068 0.947 0.977 1.19 1.179 0.9082397 nan 0.821008403 nan 0.88670412 nan 0.990756303 nan GO:0080090;GO:0019222;GO:2001141;GO:0048468;GO:0003357;GO:0060322;GO:0003016;GO:0021723;GO:0010556;GO:1901362;GO:0071840;GO:0014032;GO:0014033;GO:0007517;GO:0014031;GO:0048864;GO:0010604;GO:0048869;GO:0007519;GO:0070848;GO:0045665;GO:0045664;GO:0048513;GO:0048485;GO:0071495;GO:0010720;GO:0010721;GO:0048518;GO:0048519;GO:1901166;GO:0046483;GO:0051254;GO:0060541;GO:0048762;GO:0061548;GO:0061549;GO:0060255;GO:0048880;GO:0048731;GO:0003358;GO:0001755;GO:0010033;GO:0003008;GO:0044707;GO:0048870;GO:0071310;GO:0019438;GO:0021934;GO:0021535;GO:0051716;GO:0021533;GO:0034645;GO:0009891;GO:0048892;GO:0048894;GO:0006928;GO:0048486;GO:0048484;GO:0051674;GO:0048483;GO:0031175;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0000904;GO:0000902;GO:0044260;GO:0006357;GO:0016043;GO:0070887;GO:0065007;GO:1901360;GO:0006366;GO:0035914;GO:0016477;GO:0018130;GO:0009719;GO:0061564;GO:0006139;GO:0050793;GO:0009889;GO:0042063;GO:0050794;GO:0048863;GO:0008150;GO:0051239;GO:0021545;GO:0034654;GO:0016070;GO:0044271;GO:0007420;GO:0007423;GO:0050896;GO:0051962;GO:0051961;GO:0048812;GO:0006351;GO:0051240;GO:0071772;GO:0071773;GO:0032774;GO:0030154;GO:0021550;GO:0034641;GO:0060284;GO:0010001;GO:0042221;GO:0061061;GO:0001667;GO:0009653;GO:0044699;GO:0007417;GO:0009893;GO:0050767;GO:0044057;GO:0042127;GO:0051241;GO:0050768;GO:0050769;GO:0045666;GO:0021955;GO:0021954;GO:0021953;GO:0032502;GO:0008285;GO:0032501;GO:0008283;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:0045597;GO:0045596;GO:0045595;GO:0045893;GO:0007409;GO:0021675;GO:0008152;GO:0043576;GO:0048858;GO:0051093;GO:0044065;GO:0048839;GO:0071363;GO:0051094;GO:0051252;GO:1902680;GO:0006807;GO:0045944;GO:0001764;GO:0061451;GO:0061452;GO:0031328;GO:0030030;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0014706;GO:0002087;GO:0007275;GO:0010628;GO:0009888;GO:0003360;GO:0006355;GO:2000112;GO:0010557;GO:0032989;GO:1903508;GO:0071704;GO:0010467;GO:0051960;GO:0048925;GO:0043583;GO:0010468;GO:0048666;GO:0048667;GO:0045935;GO:0030182;GO:0019219;GO:0007585;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0060485;GO:0022008;GO:0051179;GO:0040011;GO:0044238;GO:0048699;GO:0032990;GO:0007399;GO:0071542;GO:0048857;GO:0048856;GO:0044237;GO:2000026;GO:0030902;GO:0060537;GO:0060538;GO:0044249;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;regulation of RNA biosynthetic process;cell development;noradrenergic neuron differentiation;head development;respiratory system process;medullary reticular formation development;regulation of macromolecule biosynthetic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;neural crest cell development;neural crest cell differentiation;muscle organ development;mesenchymal cell development;stem cell development;positive regulation of macromolecule metabolic process;cellular developmental process;skeletal muscle tissue development;response to growth factor;negative regulation of neuron differentiation;regulation of neuron differentiation;animal organ development;sympathetic nervous system development;cellular response to endogenous stimulus;positive regulation of cell development;negative regulation of cell development;positive regulation of biological process;negative regulation of biological process;neural crest cell migration involved in autonomic nervous system development;heterocycle metabolic process;positive regulation of RNA metabolic process;respiratory system development;mesenchymal cell differentiation;ganglion development;sympathetic ganglion development;regulation of macromolecule metabolic process;sensory system development;system development;noradrenergic neuron development;neural crest cell migration;response to organic substance;system process;single-multicellular organism process;cell motility;cellular response to organic substance;aromatic compound biosynthetic process;hindbrain tangential cell migration;cell migration in hindbrain;cellular response to stimulus;cell differentiation in hindbrain;cellular macromolecule biosynthetic process;positive regulation of biosynthetic process;lateral line nerve development;efferent axon development in a lateral line nerve;movement of cell or subcellular component;parasympathetic nervous system development;enteric nervous system development;localization of cell;autonomic nervous system development;neuron projection development;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;cellular component organization;cellular response to chemical stimulus;biological regulation;organic cyclic compound metabolic process;transcription from RNA polymerase II promoter;skeletal muscle cell differentiation;cell migration;heterocycle biosynthetic process;response to endogenous stimulus;axon development;nucleobase-containing compound metabolic process;regulation of developmental process;regulation of biosynthetic process;gliogenesis;regulation of cellular process;stem cell differentiation;biological_process;regulation of multicellular organismal process;cranial nerve development;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;brain development;sensory organ development;response to stimulus;positive regulation of nervous system development;negative regulation of nervous system development;neuron projection morphogenesis;transcription, DNA-templated;positive regulation of multicellular organismal process;response to BMP;cellular response to BMP stimulus;RNA biosynthetic process;cell differentiation;medulla oblongata development;cellular nitrogen compound metabolic process;regulation of cell development;glial cell differentiation;response to chemical;muscle structure development;ameboidal-type cell migration;anatomical structure morphogenesis;single-organism process;central nervous system development;positive regulation of metabolic process;regulation of neurogenesis;regulation of system process;regulation of cell proliferation;negative regulation of multicellular organismal process;negative regulation of neurogenesis;positive regulation of neurogenesis;positive regulation of neuron differentiation;central nervous system neuron axonogenesis;central nervous system neuron development;central nervous system neuron differentiation;developmental process;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;positive regulation of transcription, DNA-templated;axonogenesis;nerve development;metabolic process;regulation of respiratory gaseous exchange;cell projection morphogenesis;negative regulation of developmental process;regulation of respiratory system process;inner ear development;cellular response to growth factor stimulus;positive regulation of developmental process;regulation of RNA metabolic process;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;neuron migration;retrotrapezoid nucleus development;retrotrapezoid nucleus neuron differentiation;positive regulation of cellular biosynthetic process;cell projection organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;striated muscle tissue development;regulation of respiratory gaseous exchange by neurological system process;multicellular organism development;positive regulation of gene expression;tissue development;brainstem development;regulation of transcription, DNA-templated;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;cellular component morphogenesis;positive regulation of nucleic acid-templated transcription;organic substance metabolic process;gene expression;regulation of nervous system development;lateral line system development;ear development;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;regulation of nucleobase-containing compound metabolic process;respiratory gaseous exchange;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;mesenchyme development;neurogenesis;localization;locomotion;primary metabolic process;generation of neurons;cell part morphogenesis;nervous system development;dopaminergic neuron differentiation;neural nucleus development;anatomical structure development;cellular metabolic process;regulation of multicellular organismal development;hindbrain development;muscle tissue development;skeletal muscle organ development;cellular biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 4;3;6;4;7;4;4;4;5;5;2;7;7;5;6;5;4;4;7;5;6;7;4;5;4;5;5;2;2;6;4;5;5;6;5;6;4;5;4;6;6;4;3;3;3;5;5;6;5;3;5;5;4;6;7;4;5;5;3;5;5;4;2;7;4;5;5;4;7;3;4;2;4;7;6;4;5;3;6;4;3;4;7;3;6;1;3;5;5;5;5;4;4;2;4;4;6;6;3;4;5;6;5;4;4;5;6;3;4;5;3;2;5;3;6;4;4;3;5;5;6;7;6;6;2;4;2;3;4;2;4;7;4;4;4;6;7;4;2;4;5;3;5;4;6;3;5;6;3;7;5;5;6;5;4;5;4;4;5;6;5;4;5;4;4;6;6;5;4;7;3;5;5;6;5;5;5;6;5;6;5;4;3;3;5;3;4;4;5;6;2;2;3;7;5;5;7;4;3;3;4;4;5;6;4;3;3; GO:0031974;GO:0031981;GO:0032991;GO:0000790;GO:0043231;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0000228;GO:0043227;GO:0044427;GO:0044446;GO:0043226;GO:0005634;GO:0044454;GO:0044464;GO:0005623;GO:0005622;GO:0043229;GO:0043232;GO:0005694;GO:0000785;GO:0043228;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;macromolecular complex;nuclear chromatin;intracellular membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;organelle part;nuclear chromosome;membrane-bounded organelle;chromosomal part;intracellular organelle part;organelle;nucleus;nuclear chromosome part;cell part;cell;intracellular;intracellular organelle;intracellular non-membrane-bounded organelle;chromosome;chromatin;non-membrane-bounded organelle;cellular_component;intracellular organelle lumen; 2;5;2;4;4;3;4;3;2;5;3;4;3;2;5;5;2;2;3;3;4;5;3;3;1;4; GO:0001071;GO:1901363;GO:0001067;GO:0000987;GO:0044212;GO:0001077;GO:0001012;GO:0001159;GO:0003674;GO:0003676;GO:0000982;GO:0000981;GO:0097159;GO:0000976;GO:0000975;GO:0000978;GO:1990837;GO:0043565;GO:0003690;GO:0001228;GO:0005488;GO:0003677;GO:0000977;GO:0003700; nucleic acid binding transcription factor activity;heterocyclic compound binding;regulatory region nucleic acid binding;core promoter proximal region sequence-specific DNA binding;transcription regulatory region DNA binding;transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II regulatory region DNA binding;core promoter proximal region DNA binding;molecular_function;nucleic acid binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;sequence-specific double-stranded DNA binding;sequence-specific DNA binding;double-stranded DNA binding;transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;binding;DNA binding;RNA polymerase II regulatory region sequence-specific DNA binding;transcription factor activity, sequence-specific DNA binding; 2;3;5;9;7;6;8;8;1;4;5;4;3;8;6;10;7;6;6;5;2;5;9;3; K09330 IPR009057;IPR017970;IPR001356; Homeobox domain-like;Homeobox, conserved site;Homeobox domain; nucleus Hs12707580 625.0 K [K] Transcription; P31151 Protein S100-A7 OS=Homo sapiens OX=9606 GN=S100A7 PE=1 SV=4 - [S10A7_HUMAN] 1.117 1.186 0.591 1.468 1.076 0.75 0.941821248 nan 1.364312268 nan 0.498313659 nan 0.697026022 nan GO:0019220;GO:0019222;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0050920;GO:0050921;GO:0060326;GO:0044707;GO:0051716;GO:0042330;GO:2000401;GO:0009966;GO:0048869;GO:0009617;GO:0000165;GO:0051246;GO:0002685;GO:0048514;GO:0030855;GO:0048518;GO:0002682;GO:0030595;GO:0006935;GO:0030216;GO:0060255;GO:0051707;GO:0010033;GO:0051704;GO:0042325;GO:0044700;GO:0042327;GO:0065008;GO:0009607;GO:0009605;GO:0048870;GO:0019538;GO:0002376;GO:0007154;GO:0048646;GO:0007165;GO:0044710;GO:0009893;GO:0006468;GO:0000302;GO:0051674;GO:0050829;GO:0032496;GO:0048247;GO:0044267;GO:0008544;GO:0044260;GO:0010646;GO:0001568;GO:0043410;GO:0002687;GO:0002684;GO:2000403;GO:2000404;GO:0023014;GO:2000406;GO:0016477;GO:0035556;GO:0002688;GO:0016310;GO:0009888;GO:0050794;GO:0006952;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0006955;GO:1902533;GO:0051235;GO:1902531;GO:0072678;GO:0010604;GO:0051174;GO:0043207;GO:0043412;GO:0050896;GO:0031401;GO:0072676;GO:2000145;GO:0002690;GO:2000147;GO:0009967;GO:0010562;GO:0032103;GO:0032101;GO:0001944;GO:0030154;GO:0023056;GO:0023052;GO:0070887;GO:0023051;GO:0010647;GO:0009653;GO:0044699;GO:0043408;GO:0043588;GO:0006928;GO:0051247;GO:0048513;GO:0032270;GO:0097530;GO:0031399;GO:0031325;GO:0032502;GO:1901700;GO:0032501;GO:0044238;GO:0009987;GO:0051270;GO:0098542;GO:0032879;GO:0006979;GO:0002548;GO:0032268;GO:0002237;GO:0048731;GO:0070374;GO:0097529;GO:0070372;GO:0070371;GO:0042742;GO:0048856;GO:0060429;GO:0031323;GO:0051238;GO:0043170;GO:0050900;GO:0010820;GO:0001525;GO:0007275;GO:0090025;GO:0090026;GO:0033993;GO:0050789;GO:1901623;GO:0071704;GO:0071622;GO:0071621;GO:0071624;GO:0010818;GO:0010819;GO:0030335;GO:0030334;GO:0045937;GO:0045087;GO:0080090;GO:0006464;GO:0044767;GO:0044763;GO:0042221;GO:0051179;GO:0040011;GO:0051272;GO:0040012;GO:0040017;GO:0009913;GO:0065007;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048522; regulation of phosphate metabolic process;regulation of metabolic process;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;regulation of chemotaxis;positive regulation of chemotaxis;cell chemotaxis;single-multicellular organism process;cellular response to stimulus;taxis;regulation of lymphocyte migration;regulation of signal transduction;cellular developmental process;response to bacterium;MAPK cascade;regulation of protein metabolic process;regulation of leukocyte migration;blood vessel morphogenesis;epithelial cell differentiation;positive regulation of biological process;regulation of immune system process;leukocyte chemotaxis;chemotaxis;keratinocyte differentiation;regulation of macromolecule metabolic process;response to other organism;response to organic substance;multi-organism process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;regulation of biological quality;response to biotic stimulus;response to external stimulus;cell motility;protein metabolic process;immune system process;cell communication;anatomical structure formation involved in morphogenesis;signal transduction;single-organism metabolic process;positive regulation of metabolic process;protein phosphorylation;response to reactive oxygen species;localization of cell;defense response to Gram-negative bacterium;response to lipopolysaccharide;lymphocyte chemotaxis;cellular protein metabolic process;epidermis development;cellular macromolecule metabolic process;regulation of cell communication;blood vessel development;positive regulation of MAPK cascade;positive regulation of leukocyte migration;positive regulation of immune system process;positive regulation of lymphocyte migration;regulation of T cell migration;signal transduction by protein phosphorylation;positive regulation of T cell migration;cell migration;intracellular signal transduction;regulation of leukocyte chemotaxis;phosphorylation;tissue development;regulation of cellular process;defense response;response to stress;protein modification process;biological_process;metabolic process;immune response;positive regulation of intracellular signal transduction;maintenance of location;regulation of intracellular signal transduction;T cell migration;positive regulation of macromolecule metabolic process;regulation of phosphorus metabolic process;response to external biotic stimulus;macromolecule modification;response to stimulus;positive regulation of protein modification process;lymphocyte migration;regulation of cell motility;positive regulation of leukocyte chemotaxis;positive regulation of cell motility;positive regulation of signal transduction;positive regulation of phosphorus metabolic process;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;cell differentiation;positive regulation of signaling;signaling;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;regulation of MAPK cascade;skin development;movement of cell or subcellular component;positive regulation of protein metabolic process;animal organ development;positive regulation of cellular protein metabolic process;granulocyte migration;regulation of protein modification process;positive regulation of cellular metabolic process;developmental process;response to oxygen-containing compound;multicellular organismal process;primary metabolic process;cellular process;regulation of cellular component movement;defense response to other organism;regulation of localization;response to oxidative stress;monocyte chemotaxis;regulation of cellular protein metabolic process;response to molecule of bacterial origin;system development;positive regulation of ERK1 and ERK2 cascade;myeloid leukocyte migration;regulation of ERK1 and ERK2 cascade;ERK1 and ERK2 cascade;defense response to bacterium;anatomical structure development;epithelium development;regulation of cellular metabolic process;sequestering of metal ion;macromolecule metabolic process;leukocyte migration;positive regulation of T cell chemotaxis;angiogenesis;multicellular organism development;regulation of monocyte chemotaxis;positive regulation of monocyte chemotaxis;response to lipid;regulation of biological process;regulation of lymphocyte chemotaxis;organic substance metabolic process;regulation of granulocyte chemotaxis;granulocyte chemotaxis;positive regulation of granulocyte chemotaxis;T cell chemotaxis;regulation of T cell chemotaxis;positive regulation of cell migration;regulation of cell migration;positive regulation of phosphate metabolic process;innate immune response;regulation of primary metabolic process;cellular protein modification process;single-organism developmental process;single-organism cellular process;response to chemical;localization;locomotion;positive regulation of cellular component movement;regulation of locomotion;positive regulation of locomotion;epidermal cell differentiation;biological regulation;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;3;3;3;5;5;4;4;5;3;3;3;5;4;4;4;5;5;4;4;6;2;3;4;4;6;4;3;4;2;7;3;7;3;3;3;3;4;2;4;3;4;3;3;7;5;3;6;5;5;5;6;4;4;4;6;4;3;5;6;4;6;4;5;5;6;4;3;4;3;5;1;2;3;5;3;5;5;4;5;4;5;2;6;4;4;5;4;4;5;4;4;5;5;3;2;4;3;4;3;2;6;5;4;5;4;5;5;6;4;2;4;2;3;2;4;4;3;4;5;5;5;4;7;4;7;6;5;3;5;4;4;4;3;6;4;4;6;6;5;2;6;3;6;5;6;6;7;5;5;6;4;4;6;3;3;3;2;2;4;3;3;7;2;3;5;4;7;7;3; GO:0005783;GO:0030054;GO:0030055;GO:0031982;GO:0043230;GO:0043231;GO:0005829;GO:0044424;GO:0044421;GO:0043227;GO:0043226;GO:0070161;GO:0012505;GO:0044444;GO:0005737;GO:0005924;GO:0005634;GO:0005925;GO:0005912;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0070062;GO:1903561;GO:0005575;GO:0005576; endoplasmic reticulum;cell junction;cell-substrate junction;vesicle;extracellular organelle;intracellular membrane-bounded organelle;cytosol;intracellular part;extracellular region part;membrane-bounded organelle;organelle;anchoring junction;endomembrane system;cytoplasmic part;cytoplasm;cell-substrate adherens junction;nucleus;focal adhesion;adherens junction;cell part;intracellular organelle;cell;intracellular;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;2;3;4;3;4;5;3;2;3;2;3;3;4;4;4;5;5;4;2;3;2;3;4;3;1;2; GO:0046872;GO:0050786;GO:0003674;GO:0005488;GO:0008270;GO:0043169;GO:0043167;GO:0005509;GO:0005515;GO:0005102;GO:0046914; metal ion binding;RAGE receptor binding;molecular_function;binding;zinc ion binding;cation binding;ion binding;calcium ion binding;protein binding;receptor binding;transition metal ion binding; 5;5;1;2;7;4;3;6;3;4;6; K21126 IPR018247;IPR013787;IPR011992;IPR001751;IPR034325;IPR002048;IPR028477; EF-Hand 1, calcium-binding site;S100/CaBP-9k-type, calcium binding, subdomain;EF-hand domain pair;S100/Calbindin-D9k, conserved site;S-100;EF-hand domain;Protein S100-A7; cytosol P50583 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3 - [AP4A_HUMAN] 0.917 1.27 1.071 0.906 1.134 0.404 0.722047244 0.011579217 0.798941799 0.000347167 0.843307087 0.098925817 0.356261023 3.15E-05 GO:0000302;GO:0034641;GO:0006807;GO:0008219;GO:1901360;GO:0006139;GO:0071704;GO:0044699;GO:0009987;GO:0006915;GO:0006725;GO:0006950;GO:0008150;GO:0008152;GO:0042221;GO:0006979;GO:0046483;GO:1901700;GO:0044238;GO:0012501;GO:0050896;GO:0044237;GO:0044763; response to reactive oxygen species;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cell death;organic cyclic compound metabolic process;nucleobase-containing compound metabolic process;organic substance metabolic process;single-organism process;cellular process;apoptotic process;cellular aromatic compound metabolic process;response to stress;biological_process;metabolic process;response to chemical;response to oxidative stress;heterocycle metabolic process;response to oxygen-containing compound;primary metabolic process;programmed cell death;response to stimulus;cellular metabolic process;single-organism cellular process; 5;4;3;4;4;4;3;2;2;6;4;3;1;2;3;4;4;4;3;5;2;3;3; GO:0044464;GO:0031974;GO:0005623;GO:0043227;GO:0043226;GO:0005737;GO:0070013;GO:0005739;GO:0005759;GO:0044429;GO:0043229;GO:0044446;GO:0043231;GO:0043233;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044422; cell part;membrane-enclosed lumen;cell;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle lumen;mitochondrion;mitochondrial matrix;mitochondrial part;intracellular organelle;intracellular organelle part;intracellular membrane-bounded organelle;organelle lumen;intracellular;cellular_component;cytoplasmic part;intracellular part;organelle part; 2;2;2;3;2;4;4;5;5;4;3;3;4;3;3;1;4;3;2; GO:0008803;GO:0035639;GO:1901363;GO:0032553;GO:0003674;GO:0001883;GO:0043167;GO:0001882;GO:0000166;GO:0032555;GO:0004081;GO:0032549;GO:0017076;GO:0032561;GO:0016787;GO:1901265;GO:0036094;GO:0003824;GO:0019001;GO:0016818;GO:0097367;GO:0097159;GO:0008796;GO:0016817;GO:0016462;GO:0032550;GO:0004551;GO:0005525;GO:0043168;GO:0005488; bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity;purine ribonucleoside triphosphate binding;heterocyclic compound binding;ribonucleotide binding;molecular_function;purine nucleoside binding;ion binding;nucleoside binding;nucleotide binding;purine ribonucleotide binding;bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;ribonucleoside binding;purine nucleotide binding;guanyl ribonucleotide binding;hydrolase activity;nucleoside phosphate binding;small molecule binding;catalytic activity;guanyl nucleotide binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;organic cyclic compound binding;bis(5'-nucleosyl)-tetraphosphatase activity;hydrolase activity, acting on acid anhydrides;pyrophosphatase activity;purine ribonucleoside binding;nucleotide diphosphatase activity;GTP binding;anion binding;binding; 9;5;3;4;1;5;3;4;4;5;9;5;5;6;3;4;3;2;6;5;3;3;8;4;6;6;7;6;4;2; K01518 map00230;map00240; Purine metabolism;Pyrimidine metabolism; IPR003565;IPR020084;IPR000086;IPR015797; Bis(5'-nucleosyl)-tetraphosphatase;NUDIX hydrolase, conserved site;NUDIX hydrolase domain;NUDIX hydrolase domain-like; mitochondria Hs4502125 304.0 T [T] Signal transduction mechanisms; O14529 Homeobox protein cut-like 2 OS=Homo sapiens OX=9606 GN=CUX2 PE=1 SV=4 - [CUX2_HUMAN] 0.873 0.795 1.718 0.807 0.81 1.018 1.098113208 nan 0.996296296 nan 2.161006289 nan 1.256790123 nan GO:0080090;GO:0019222;GO:0007614;GO:0048584;GO:0048468;GO:0016358;GO:0007610;GO:0007611;GO:0007165;GO:0007166;GO:1901362;GO:0031344;GO:0071840;GO:0031346;GO:0097061;GO:0051716;GO:0010605;GO:0009966;GO:0048869;GO:0071310;GO:0045664;GO:0060998;GO:0045666;GO:0010720;GO:0044085;GO:0048518;GO:0048519;GO:0031324;GO:0003008;GO:0060996;GO:0060997;GO:0044700;GO:0060255;GO:0048583;GO:0007613;GO:0042221;GO:0010976;GO:0010975;GO:2001141;GO:0050804;GO:0010033;GO:0046483;GO:0023056;GO:0044707;GO:0044708;GO:0060079;GO:0098916;GO:0019438;GO:0022604;GO:0042391;GO:0022607;GO:0009892;GO:0070887;GO:0009890;GO:0022603;GO:0061003;GO:0061001;GO:0098815;GO:0008152;GO:0010629;GO:0006807;GO:0031175;GO:0050789;GO:0097659;GO:1901576;GO:0000904;GO:0000902;GO:0044260;GO:0006357;GO:0010646;GO:0016043;GO:0065007;GO:1901360;GO:0006366;GO:0065008;GO:0018130;GO:0051130;GO:2000463;GO:0050793;GO:0009889;GO:0050794;GO:0008150;GO:0051239;GO:0010770;GO:0034654;GO:0060078;GO:0010604;GO:0016070;GO:1902679;GO:0044271;GO:0050896;GO:0050890;GO:0051963;GO:0051962;GO:0048813;GO:0048812;GO:0048814;GO:0051965;GO:0009967;GO:0010558;GO:0099536;GO:0099537;GO:0050808;GO:0032774;GO:0050803;GO:0030154;GO:0050807;GO:0050806;GO:0051128;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0023051;GO:0010647;GO:0009653;GO:0044699;GO:0009893;GO:0050767;GO:0000122;GO:0051240;GO:0060284;GO:0050769;GO:0031327;GO:0010769;GO:0032502;GO:0032501;GO:0010556;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045597;GO:0045595;GO:0045892;GO:0048858;GO:0050775;GO:0050773;GO:0051094;GO:0051253;GO:0051252;GO:0043170;GO:0006139;GO:0048731;GO:0030030;GO:0031326;GO:0031323;GO:0090304;GO:0060999;GO:0007275;GO:0010628;GO:1900006;GO:0006355;GO:2000112;GO:2000113;GO:0032989;GO:0071704;GO:0010467;GO:0051960;GO:0010468;GO:0006351;GO:0048666;GO:0048667;GO:0045934;GO:0030182;GO:0019219;GO:0007416;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051172;GO:0007268;GO:0007267;GO:0007154;GO:0022008;GO:0044238;GO:0048699;GO:0032990;GO:0007399;GO:0099565;GO:0048856;GO:0044237;GO:0044087;GO:2000026;GO:1905114;GO:0044089;GO:0048523;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;short-term memory;positive regulation of response to stimulus;cell development;dendrite development;behavior;learning or memory;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;dendritic spine organization;cellular response to stimulus;negative regulation of macromolecule metabolic process;regulation of signal transduction;cellular developmental process;cellular response to organic substance;regulation of neuron differentiation;regulation of dendritic spine development;positive regulation of neuron differentiation;positive regulation of cell development;cellular component biogenesis;positive regulation of biological process;negative regulation of biological process;negative regulation of cellular metabolic process;system process;dendritic spine development;dendritic spine morphogenesis;single organism signaling;regulation of macromolecule metabolic process;regulation of response to stimulus;memory;response to chemical;positive regulation of neuron projection development;regulation of neuron projection development;regulation of RNA biosynthetic process;modulation of synaptic transmission;response to organic substance;heterocycle metabolic process;positive regulation of signaling;single-multicellular organism process;single-organism behavior;excitatory postsynaptic potential;anterograde trans-synaptic signaling;aromatic compound biosynthetic process;regulation of cell morphogenesis;regulation of membrane potential;cellular component assembly;negative regulation of metabolic process;cellular response to chemical stimulus;negative regulation of biosynthetic process;regulation of anatomical structure morphogenesis;positive regulation of dendritic spine morphogenesis;regulation of dendritic spine morphogenesis;modulation of excitatory postsynaptic potential;metabolic process;negative regulation of gene expression;nitrogen compound metabolic process;neuron projection development;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cell morphogenesis involved in differentiation;cell morphogenesis;cellular macromolecule metabolic process;regulation of transcription from RNA polymerase II promoter;regulation of cell communication;cellular component organization;biological regulation;organic cyclic compound metabolic process;transcription from RNA polymerase II promoter;regulation of biological quality;heterocycle biosynthetic process;positive regulation of cellular component organization;positive regulation of excitatory postsynaptic potential;regulation of developmental process;regulation of biosynthetic process;regulation of cellular process;biological_process;regulation of multicellular organismal process;positive regulation of cell morphogenesis involved in differentiation;nucleobase-containing compound biosynthetic process;regulation of postsynaptic membrane potential;positive regulation of macromolecule metabolic process;RNA metabolic process;negative regulation of RNA biosynthetic process;cellular nitrogen compound biosynthetic process;response to stimulus;cognition;regulation of synapse assembly;positive regulation of nervous system development;dendrite morphogenesis;neuron projection morphogenesis;regulation of dendrite morphogenesis;positive regulation of synapse assembly;positive regulation of signal transduction;negative regulation of macromolecule biosynthetic process;synaptic signaling;trans-synaptic signaling;synapse organization;RNA biosynthetic process;regulation of synapse structure or activity;cell differentiation;regulation of synapse organization;positive regulation of synaptic transmission;regulation of cellular component organization;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;single-organism process;positive regulation of metabolic process;regulation of neurogenesis;negative regulation of transcription from RNA polymerase II promoter;positive regulation of multicellular organismal process;regulation of cell development;positive regulation of neurogenesis;negative regulation of cellular biosynthetic process;regulation of cell morphogenesis involved in differentiation;developmental process;multicellular organismal process;regulation of macromolecule biosynthetic process;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;positive regulation of cell differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;cell projection morphogenesis;positive regulation of dendrite morphogenesis;regulation of dendrite development;positive regulation of developmental process;negative regulation of RNA metabolic process;regulation of RNA metabolic process;macromolecule metabolic process;nucleobase-containing compound metabolic process;system development;cell projection organization;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of dendritic spine development;multicellular organism development;positive regulation of gene expression;positive regulation of dendrite development;regulation of transcription, DNA-templated;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;cellular component morphogenesis;organic substance metabolic process;gene expression;regulation of nervous system development;regulation of gene expression;transcription, DNA-templated;neuron development;cell morphogenesis involved in neuron differentiation;negative regulation of nucleobase-containing compound metabolic process;neuron differentiation;regulation of nucleobase-containing compound metabolic process;synapse assembly;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;synaptic transmission;cell-cell signaling;cell communication;neurogenesis;primary metabolic process;generation of neurons;cell part morphogenesis;nervous system development;chemical synaptic transmission, postsynaptic;anatomical structure development;cellular metabolic process;regulation of cellular component biogenesis;regulation of multicellular organismal development;cell surface receptor signaling pathway involved in cell-cell signaling;positive regulation of cellular component biogenesis;negative regulation of cellular process;positive regulation of cellular process; 4;3;6;3;4;4;2;4;4;5;5;5;2;5;5;3;4;4;4;5;7;5;6;5;3;2;2;4;3;4;5;3;4;3;5;3;6;6;6;4;4;4;3;3;3;6;7;5;5;4;4;3;4;4;4;6;6;5;2;5;3;5;2;7;4;5;5;4;7;4;3;2;4;7;3;5;4;5;3;4;3;1;3;5;5;5;4;5;6;5;2;5;4;4;5;6;6;4;4;5;5;6;4;6;4;5;5;4;4;4;4;2;5;3;4;3;2;3;6;7;3;5;5;5;6;2;2;5;4;2;4;7;7;4;4;6;5;6;5;3;5;5;4;4;4;4;5;4;5;5;4;5;5;6;6;6;4;3;5;5;5;6;5;6;5;6;5;5;3;3;5;3;4;4;8;4;4;6;3;7;5;5;6;3;3;3;4;5;3;3;3; GO:0031982;GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0005622;GO:0043227;GO:0043226;GO:0044464;GO:0043229;GO:0005623;GO:0005634;GO:0070062;GO:1903561;GO:0005575;GO:0005576; vesicle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;intracellular;membrane-bounded organelle;organelle;cell part;intracellular organelle;cell;nucleus;extracellular exosome;extracellular vesicle;cellular_component;extracellular region; 4;3;4;3;2;3;3;2;2;3;2;5;4;3;1;2; GO:0000977;GO:0001067;GO:0001071;GO:0003674;GO:0005488;GO:0003676;GO:0001078;GO:1901363;GO:0000987;GO:0000982;GO:0000981;GO:0043565;GO:0097159;GO:0000976;GO:0000978;GO:1990837;GO:0003690;GO:0001159;GO:0044212;GO:0001227;GO:0003700;GO:0001012;GO:0003677;GO:0000975; RNA polymerase II regulatory region sequence-specific DNA binding;regulatory region nucleic acid binding;nucleic acid binding transcription factor activity;molecular_function;binding;nucleic acid binding;transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;heterocyclic compound binding;core promoter proximal region sequence-specific DNA binding;transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;RNA polymerase II transcription factor activity, sequence-specific DNA binding;sequence-specific DNA binding;organic cyclic compound binding;transcription regulatory region sequence-specific DNA binding;RNA polymerase II core promoter proximal region sequence-specific DNA binding;sequence-specific double-stranded DNA binding;double-stranded DNA binding;core promoter proximal region DNA binding;transcription regulatory region DNA binding;transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;transcription factor activity, sequence-specific DNA binding;RNA polymerase II regulatory region DNA binding;DNA binding;regulatory region DNA binding; 9;5;2;1;2;4;6;3;9;5;4;6;3;8;10;7;6;8;7;5;3;8;5;6; K09313 IPR010982;IPR009057;IPR017970;IPR001356;IPR003350; Lambda repressor-like, DNA-binding domain;Homeobox domain-like;Homeobox, conserved site;Homeobox domain;CUT domain; nucleus Hs22061919_2 1882.0 K [K] Transcription; O75715 Epididymal secretory glutathione peroxidase OS=Homo sapiens OX=9606 GN=GPX5 PE=1 SV=1 - [GPX5_HUMAN] 0.892 0.858 1.055 1.26 0.837 2.162 1.03962704 nan 1.505376344 nan 1.22960373 nan 2.583034648 nan GO:0070887;GO:0044699;GO:0051716;GO:0071704;GO:0006629;GO:0009987;GO:0044710;GO:0006950;GO:0008150;GO:0008152;GO:0042221;GO:0034599;GO:0006979;GO:0044238;GO:0050896;GO:0033554; cellular response to chemical stimulus;single-organism process;cellular response to stimulus;organic substance metabolic process;lipid metabolic process;cellular process;single-organism metabolic process;response to stress;biological_process;metabolic process;response to chemical;cellular response to oxidative stress;response to oxidative stress;primary metabolic process;response to stimulus;cellular response to stress; 4;2;3;3;4;2;3;3;1;2;3;5;4;3;2;4; GO:0071944;GO:0005615;GO:0016020;GO:0097223;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0097524;GO:0005576;GO:0044421; cell periphery;extracellular space;membrane;sperm part;plasma membrane;cell part;cell;cellular_component;sperm plasma membrane;extracellular region;extracellular region part; 3;3;2;3;3;2;2;1;4;2;2; GO:0003674;GO:0016491;GO:0016684;GO:0016209;GO:0003824;GO:0004601;GO:0004602; molecular_function;oxidoreductase activity;oxidoreductase activity, acting on peroxide as acceptor;antioxidant activity;catalytic activity;peroxidase activity;glutathione peroxidase activity; 1;3;4;2;2;3;4; K00432 map00480;map00590;map04918; Glutathione metabolism;Arachidonic acid metabolism;Thyroid hormone synthesis; IPR029759;IPR000889;IPR012336;IPR029760; Glutathione peroxidase active site;Glutathione peroxidase;Thioredoxin-like fold;Glutathione peroxidase conserved site; extracellular Hs4557629 459.0 O [O] Posttranslational modification, protein turnover, chaperones; Q6UXL0 Interleukin-20 receptor subunit beta OS=Homo sapiens OX=9606 GN=IL20RB PE=1 SV=1 - [I20RB_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0042130;GO:0032623;GO:0019221;GO:0034111;GO:0034110;GO:0048585;GO:0002865;GO:0048583;GO:0002707;GO:0002706;GO:0007162;GO:0002704;GO:0002703;GO:0007165;GO:0007166;GO:0002456;GO:0031347;GO:0051716;GO:0070663;GO:0048518;GO:0065007;GO:0002674;GO:0042127;GO:0032653;GO:0002822;GO:0002823;GO:0042129;GO:0046649;GO:0002673;GO:0010033;GO:0048872;GO:0044700;GO:0065008;GO:0048873;GO:0048871;GO:0044707;GO:0031348;GO:0002376;GO:0002524;GO:0070489;GO:0032733;GO:0032649;GO:0032943;GO:0032944;GO:0032945;GO:0046651;GO:0050789;GO:0009605;GO:0002438;GO:0002765;GO:0002764;GO:0042098;GO:0002437;GO:0032703;GO:0002682;GO:0002683;GO:0060249;GO:0071593;GO:0098602;GO:0034097;GO:0098609;GO:0050728;GO:0050794;GO:0006952;GO:0001775;GO:0008150;GO:0006954;GO:0006955;GO:0002526;GO:0002883;GO:0002884;GO:0002449;GO:0071345;GO:0050896;GO:0006950;GO:0002695;GO:0002694;GO:0002697;GO:0007159;GO:0009611;GO:0032102;GO:0051239;GO:0032101;GO:0030155;GO:0002819;GO:0050727;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0051249;GO:0051240;GO:0051241;GO:1903038;GO:0032673;GO:0022610;GO:1903034;GO:1903035;GO:1903037;GO:0008285;GO:0032501;GO:0008283;GO:0032613;GO:0009987;GO:0002862;GO:0002861;GO:0042110;GO:0002864;GO:0048519;GO:0001894;GO:0050777;GO:0050776;GO:0002460;GO:0045321;GO:0051250;GO:0050670;GO:0050672;GO:0001816;GO:0001817;GO:0032663;GO:0080134;GO:0001818;GO:0001819;GO:0032609;GO:0016337;GO:0050868;GO:0050865;GO:0002709;GO:0050866;GO:0050863;GO:0042592;GO:0022407;GO:0022408;GO:0002443;GO:0070661;GO:0071310;GO:0001806;GO:0070664;GO:0001808;GO:0034109;GO:0032633;GO:0002710;GO:0032689;GO:0044763;GO:0002820;GO:0007155;GO:0007154;GO:0070486;GO:0001807;GO:0002698;GO:0002250;GO:0002252;GO:0032753;GO:0048523; negative regulation of T cell proliferation;interleukin-2 production;cytokine-mediated signaling pathway;negative regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;negative regulation of response to stimulus;negative regulation of acute inflammatory response to antigenic stimulus;regulation of response to stimulus;negative regulation of lymphocyte mediated immunity;regulation of lymphocyte mediated immunity;negative regulation of cell adhesion;negative regulation of leukocyte mediated immunity;regulation of leukocyte mediated immunity;signal transduction;cell surface receptor signaling pathway;T cell mediated immunity;regulation of defense response;cellular response to stimulus;regulation of leukocyte proliferation;positive regulation of biological process;biological regulation;negative regulation of acute inflammatory response;regulation of cell proliferation;regulation of interleukin-10 production;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of T cell proliferation;lymphocyte activation;regulation of acute inflammatory response;response to organic substance;homeostasis of number of cells;single organism signaling;regulation of biological quality;homeostasis of number of cells within a tissue;multicellular organismal homeostasis;single-multicellular organism process;negative regulation of defense response;immune system process;hypersensitivity;T cell aggregation;positive regulation of interleukin-10 production;regulation of interferon-gamma production;mononuclear cell proliferation;regulation of mononuclear cell proliferation;negative regulation of mononuclear cell proliferation;lymphocyte proliferation;regulation of biological process;response to external stimulus;acute inflammatory response to antigenic stimulus;immune response-inhibiting signal transduction;immune response-regulating signaling pathway;T cell proliferation;inflammatory response to antigenic stimulus;negative regulation of interleukin-2 production;regulation of immune system process;negative regulation of immune system process;anatomical structure homeostasis;lymphocyte aggregation;single organism cell adhesion;response to cytokine;cell-cell adhesion;negative regulation of inflammatory response;regulation of cellular process;defense response;cell activation;biological_process;inflammatory response;immune response;acute inflammatory response;regulation of hypersensitivity;negative regulation of hypersensitivity;lymphocyte mediated immunity;cellular response to cytokine stimulus;response to stimulus;response to stress;negative regulation of leukocyte activation;regulation of leukocyte activation;regulation of immune effector process;leukocyte cell-cell adhesion;response to wounding;negative regulation of response to external stimulus;regulation of multicellular organismal process;regulation of response to external stimulus;regulation of cell adhesion;regulation of adaptive immune response;regulation of inflammatory response;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;regulation of lymphocyte activation;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;negative regulation of leukocyte cell-cell adhesion;regulation of interleukin-4 production;biological adhesion;regulation of response to wounding;negative regulation of response to wounding;regulation of leukocyte cell-cell adhesion;negative regulation of cell proliferation;multicellular organismal process;cell proliferation;interleukin-10 production;cellular process;negative regulation of inflammatory response to antigenic stimulus;regulation of inflammatory response to antigenic stimulus;T cell activation;regulation of acute inflammatory response to antigenic stimulus;negative regulation of biological process;tissue homeostasis;negative regulation of immune response;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;leukocyte activation;negative regulation of lymphocyte activation;regulation of lymphocyte proliferation;negative regulation of lymphocyte proliferation;cytokine production;regulation of cytokine production;regulation of interleukin-2 production;regulation of response to stress;negative regulation of cytokine production;positive regulation of cytokine production;interferon-gamma production;single organismal cell-cell adhesion;negative regulation of T cell activation;regulation of cell activation;regulation of T cell mediated immunity;negative regulation of cell activation;regulation of T cell activation;homeostatic process;regulation of cell-cell adhesion;negative regulation of cell-cell adhesion;leukocyte mediated immunity;leukocyte proliferation;cellular response to organic substance;type IV hypersensitivity;negative regulation of leukocyte proliferation;negative regulation of type IV hypersensitivity;homotypic cell-cell adhesion;interleukin-4 production;negative regulation of T cell mediated immunity;negative regulation of interferon-gamma production;single-organism cellular process;negative regulation of adaptive immune response;cell adhesion;cell communication;leukocyte aggregation;regulation of type IV hypersensitivity;negative regulation of immune effector process;adaptive immune response;immune effector process;positive regulation of interleukin-4 production;negative regulation of cellular process; 7;5;6;6;6;3;6;3;6;6;4;5;5;4;5;6;5;3;5;2;2;6;4;5;6;6;7;4;6;4;5;3;3;6;4;3;4;2;6;4;5;5;5;6;6;5;2;3;5;6;5;6;4;5;3;3;5;7;3;5;4;5;3;4;4;1;5;3;6;7;7;5;6;2;3;4;4;4;5;4;4;3;4;4;5;5;2;4;3;2;5;3;3;6;5;2;5;4;6;4;2;3;5;2;5;5;5;6;2;5;4;4;5;3;5;6;6;4;4;5;4;4;4;5;4;6;4;7;4;6;4;5;5;4;4;5;7;5;8;5;5;7;5;3;5;3;4;6;8;4;4;3;5;3; GO:0016021;GO:0016020;GO:0044425;GO:0044464;GO:0005623;GO:0031224;GO:0071944;GO:0005886;GO:0005575; integral component of membrane;membrane;membrane part;cell part;cell;intrinsic component of membrane;cell periphery;plasma membrane;cellular_component; 4;2;2;2;2;3;3;3;1; GO:0004896;GO:0003674;GO:0060089;GO:0099600;GO:0038023;GO:0004872;GO:0004871;GO:0004888; cytokine receptor activity;molecular_function;molecular transducer activity;transmembrane receptor activity;signaling receptor activity;receptor activity;signal transducer activity;transmembrane signaling receptor activity; 5;1;2;4;3;3;2;4; K05137 map04060;map04630; Cytokine-cytokine receptor interaction;Jak-STAT signaling pathway; IPR003961;IPR013783;IPR015373; Fibronectin type III;Immunoglobulin-like fold;Interferon/interleukin receptor domain; extracellular P56199 Integrin alpha-1 OS=Homo sapiens OX=9606 GN=ITGA1 PE=1 SV=2 - [ITA1_HUMAN] 0.799 0.821 1.593 0.811 1.031 0.956 0.97320341 nan 0.786614937 nan 1.940316687 nan 0.927255092 nan GO:0019220;GO:0080090;GO:0019222;GO:0006470;GO:0048585;GO:0048584;GO:0048583;GO:0032147;GO:0007160;GO:0043523;GO:0007165;GO:0007166;GO:0007167;GO:0003018;GO:0007599;GO:0032989;GO:0023014;GO:0030182;GO:0051716;GO:0007409;GO:0010604;GO:0009968;GO:0009966;GO:0009967;GO:0071840;GO:0000165;GO:0009611;GO:0044093;GO:0010921;GO:0048518;GO:0048519;GO:0042127;GO:0031589;GO:0007596;GO:0030593;GO:0006935;GO:0060255;GO:0048468;GO:0045859;GO:0042221;GO:0007173;GO:0097485;GO:0003008;GO:0042325;GO:0044700;GO:0042327;GO:0016477;GO:0044707;GO:0023057;GO:0019538;GO:0048870;GO:0003012;GO:0002376;GO:0003013;GO:0038127;GO:0048858;GO:0009893;GO:0033674;GO:0060326;GO:0006936;GO:0006928;GO:0051674;GO:0007169;GO:0071902;GO:0035556;GO:0071900;GO:0050789;GO:0009605;GO:0044267;GO:0009653;GO:0051347;GO:0000902;GO:0044260;GO:0070997;GO:0043549;GO:0016043;GO:0090066;GO:0030198;GO:0065007;GO:0043085;GO:0065009;GO:0065008;GO:0035150;GO:0061564;GO:0008015;GO:0050790;GO:0044710;GO:0042060;GO:0050794;GO:0043410;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0048731;GO:1901216;GO:1902533;GO:0035303;GO:1902531;GO:0035304;GO:0035307;GO:0035306;GO:0051336;GO:0044767;GO:0043666;GO:0050896;GO:0031401;GO:0006950;GO:0051338;GO:0050817;GO:0048869;GO:0007275;GO:0016311;GO:0016310;GO:0010922;GO:0030154;GO:0023056;GO:0043406;GO:0043405;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0007411;GO:0010647;GO:0010646;GO:1901214;GO:0044699;GO:0043408;GO:0050880;GO:0010562;GO:0051246;GO:0051247;GO:0030030;GO:0032270;GO:0031399;GO:0022610;GO:0032502;GO:0008285;GO:0032501;GO:0097530;GO:0050878;GO:0008283;GO:0009987;GO:0032990;GO:0032268;GO:0043170;GO:0045860;GO:0097529;GO:0007229;GO:0000187;GO:0048856;GO:0032516;GO:0042311;GO:0031325;GO:0031175;GO:0031323;GO:0030595;GO:0042059;GO:0042058;GO:0050900;GO:0010942;GO:0008219;GO:0010941;GO:1990266;GO:1901184;GO:1901185;GO:0043525;GO:0042981;GO:0043065;GO:0071704;GO:0043067;GO:0048812;GO:0043062;GO:0071621;GO:0043068;GO:0048666;GO:0048667;GO:0006468;GO:0045937;GO:0006915;GO:0006464;GO:0051174;GO:0051402;GO:0000904;GO:0044763;GO:0007155;GO:0007154;GO:0022008;GO:0051179;GO:0040011;GO:0044238;GO:0048699;GO:0051345;GO:0007399;GO:0045123;GO:0042330;GO:0044237;GO:0006796;GO:0006793;GO:0001932;GO:0001934;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;activation of protein kinase activity;cell-matrix adhesion;regulation of neuron apoptotic process;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;vascular process in circulatory system;hemostasis;cellular component morphogenesis;signal transduction by protein phosphorylation;neuron differentiation;cellular response to stimulus;axonogenesis;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;MAPK cascade;response to wounding;positive regulation of molecular function;regulation of phosphatase activity;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;blood coagulation;neutrophil chemotaxis;chemotaxis;regulation of macromolecule metabolic process;cell development;regulation of protein kinase activity;response to chemical;epidermal growth factor receptor signaling pathway;neuron projection guidance;system process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;cell migration;single-multicellular organism process;negative regulation of signaling;protein metabolic process;cell motility;muscle system process;immune system process;circulatory system process;ERBB signaling pathway;cell projection morphogenesis;positive regulation of metabolic process;positive regulation of kinase activity;cell chemotaxis;muscle contraction;movement of cell or subcellular component;localization of cell;transmembrane receptor protein tyrosine kinase signaling pathway;positive regulation of protein serine/threonine kinase activity;intracellular signal transduction;regulation of protein serine/threonine kinase activity;regulation of biological process;response to external stimulus;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;cell morphogenesis;cellular macromolecule metabolic process;neuron death;regulation of kinase activity;cellular component organization;regulation of anatomical structure size;extracellular matrix organization;biological regulation;positive regulation of catalytic activity;regulation of molecular function;regulation of biological quality;regulation of tube size;axon development;blood circulation;regulation of catalytic activity;single-organism metabolic process;wound healing;regulation of cellular process;positive regulation of MAPK cascade;programmed cell death;macromolecule modification;protein modification process;biological_process;metabolic process;system development;positive regulation of neuron death;positive regulation of intracellular signal transduction;regulation of dephosphorylation;regulation of intracellular signal transduction;regulation of protein dephosphorylation;positive regulation of protein dephosphorylation;positive regulation of dephosphorylation;regulation of hydrolase activity;single-organism developmental process;regulation of phosphoprotein phosphatase activity;response to stimulus;positive regulation of protein modification process;response to stress;regulation of transferase activity;coagulation;cellular developmental process;multicellular organism development;dephosphorylation;phosphorylation;positive regulation of phosphatase activity;cell differentiation;positive regulation of signaling;positive regulation of MAP kinase activity;regulation of MAP kinase activity;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;axon guidance;positive regulation of cell communication;regulation of cell communication;regulation of neuron death;single-organism process;regulation of MAPK cascade;regulation of blood vessel size;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;cell projection organization;positive regulation of cellular protein metabolic process;regulation of protein modification process;biological adhesion;developmental process;negative regulation of cell proliferation;multicellular organismal process;granulocyte migration;regulation of body fluid levels;cell proliferation;cellular process;cell part morphogenesis;regulation of cellular protein metabolic process;macromolecule metabolic process;positive regulation of protein kinase activity;myeloid leukocyte migration;integrin-mediated signaling pathway;activation of MAPK activity;anatomical structure development;positive regulation of phosphoprotein phosphatase activity;vasodilation;positive regulation of cellular metabolic process;neuron projection development;regulation of cellular metabolic process;leukocyte chemotaxis;negative regulation of epidermal growth factor receptor signaling pathway;regulation of epidermal growth factor receptor signaling pathway;leukocyte migration;positive regulation of cell death;cell death;regulation of cell death;neutrophil migration;regulation of ERBB signaling pathway;negative regulation of ERBB signaling pathway;positive regulation of neuron apoptotic process;regulation of apoptotic process;positive regulation of apoptotic process;organic substance metabolic process;regulation of programmed cell death;neuron projection morphogenesis;extracellular structure organization;granulocyte chemotaxis;positive regulation of programmed cell death;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;positive regulation of phosphate metabolic process;apoptotic process;cellular protein modification process;regulation of phosphorus metabolic process;neuron apoptotic process;cell morphogenesis involved in differentiation;single-organism cellular process;cell adhesion;cell communication;neurogenesis;localization;locomotion;primary metabolic process;generation of neurons;positive regulation of hydrolase activity;nervous system development;cellular extravasation;taxis;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;7;3;3;3;9;5;6;4;5;6;5;5;4;4;6;3;7;4;4;4;4;2;5;4;4;6;2;2;4;4;5;6;4;4;4;7;3;9;5;3;7;3;7;4;3;3;4;3;4;2;4;8;5;3;7;5;5;4;3;7;9;5;8;2;3;5;3;6;5;4;5;6;3;4;5;2;5;3;3;5;6;5;4;3;5;3;6;5;5;5;1;2;4;5;5;7;5;7;7;7;5;3;7;2;6;3;5;4;4;4;6;6;7;5;3;7;7;2;4;4;3;6;4;4;5;2;6;6;5;5;5;4;5;6;2;2;4;2;5;4;3;2;5;5;4;8;4;6;8;3;8;7;4;5;4;4;6;6;3;4;4;4;6;5;5;6;6;6;3;5;6;4;5;5;5;6;7;6;6;6;5;6;5;3;3;4;6;2;2;3;7;6;5;4;3;3;5;4;7;7;3;3; GO:0031224;GO:0042995;GO:0097458;GO:0016020;GO:0031988;GO:0043234;GO:0099503;GO:0043235;GO:0044297;GO:0036477;GO:0043230;GO:0043231;GO:0030054;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0009897;GO:0030055;GO:0043229;GO:0043227;GO:0043025;GO:0045121;GO:0070161;GO:0030141;GO:0012505;GO:0034665;GO:0016023;GO:0044444;GO:0016021;GO:0097708;GO:0098636;GO:0097223;GO:0031226;GO:0005737;GO:0005924;GO:0031410;GO:0043005;GO:0044459;GO:0005925;GO:0009986;GO:0005912;GO:0001669;GO:0044464;GO:0005623;GO:0071944;GO:0098552;GO:0098797;GO:0098589;GO:0070062;GO:0098805;GO:0098802;GO:0043226;GO:0005622;GO:0008305;GO:0031982;GO:0005887;GO:0005886;GO:1903561;GO:0032991;GO:0043204;GO:0005575;GO:0098796;GO:0005576;GO:0045178; intrinsic component of membrane;cell projection;neuron part;membrane;membrane-bounded vesicle;protein complex;secretory vesicle;receptor complex;cell body;somatodendritic compartment;extracellular organelle;intracellular membrane-bounded organelle;cell junction;intracellular part;membrane part;membrane microdomain;extracellular region part;external side of plasma membrane;cell-substrate junction;intracellular organelle;membrane-bounded organelle;neuronal cell body;membrane raft;anchoring junction;secretory granule;endomembrane system;integrin alpha1-beta1 complex;cytoplasmic, membrane-bounded vesicle;cytoplasmic part;integral component of membrane;intracellular vesicle;protein complex involved in cell adhesion;sperm part;intrinsic component of plasma membrane;cytoplasm;cell-substrate adherens junction;cytoplasmic vesicle;neuron projection;plasma membrane part;focal adhesion;cell surface;adherens junction;acrosomal vesicle;cell part;cell;cell periphery;side of membrane;plasma membrane protein complex;membrane region;extracellular exosome;whole membrane;plasma membrane receptor complex;organelle;intracellular;integrin complex;vesicle;integral component of plasma membrane;plasma membrane;extracellular vesicle;macromolecular complex;perikaryon;cellular_component;membrane protein complex;extracellular region;basal part of cell; 3;3;3;2;5;3;6;4;3;4;3;4;2;3;2;4;2;4;3;3;3;4;5;3;4;3;6;5;4;4;4;4;3;4;4;4;5;4;3;5;3;4;4;2;2;3;3;4;3;4;3;4;2;3;5;4;4;3;3;2;4;1;3;2;3; GO:0046872;GO:0019902;GO:0044877;GO:0005488;GO:0005518;GO:0098634;GO:0098631;GO:0098639;GO:0019899;GO:0043169;GO:0043167;GO:0032403;GO:0005515;GO:0003674;GO:0019903; metal ion binding;phosphatase binding;macromolecular complex binding;binding;collagen binding;protein binding involved in cell-matrix adhesion;protein binding involved in cell adhesion;collagen binding involved in cell-matrix adhesion;enzyme binding;cation binding;ion binding;protein complex binding;protein binding;molecular_function;protein phosphatase binding; 5;5;3;2;5;5;4;6;4;4;3;4;3;1;6; K06480 map04151;map04510;map04512;map04640;map04810;map05410;map05412;map05414; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy; IPR002035;IPR013519;IPR013517;IPR013649;IPR018184;IPR000413;IPR032695; von Willebrand factor, type A;Integrin alpha beta-propellor;FG-GAP repeat;Integrin alpha-2;Integrin alpha chain, C-terminal cytoplasmic region, conserved site;Integrin alpha chain;Integrin domain; plasma membrane Hs20545280 1600.0 W [W] Extracellular structures; Q8TD47 40S ribosomal protein S4, Y isoform 2 OS=Homo sapiens OX=9606 GN=RPS4Y2 PE=2 SV=3 - [RS4Y2_HUMAN] 0.947 0.86 1.04 0.779 1.073 2.537 1.101162791 nan 0.726001864 nan 1.209302326 nan 2.364398882 nan GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901576;GO:0044260;GO:0043043;GO:0071704;GO:0010467;GO:0044267;GO:0009987;GO:0009058;GO:0009059;GO:0008150;GO:0008152;GO:1901564;GO:0043604;GO:0044238;GO:0044271;GO:0043603;GO:1901566;GO:0019538;GO:0044237;GO:0043170;GO:0006518;GO:0006412; cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;peptide biosynthetic process;organic substance metabolic process;gene expression;cellular protein metabolic process;cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;metabolic process;organonitrogen compound metabolic process;amide biosynthetic process;primary metabolic process;cellular nitrogen compound biosynthetic process;cellular amide metabolic process;organonitrogen compound biosynthetic process;protein metabolic process;cellular metabolic process;macromolecule metabolic process;peptide metabolic process;translation; 4;4;3;5;4;4;6;3;5;5;2;3;5;1;2;4;6;3;5;5;5;4;3;4;5;6; GO:0022626;GO:0015935;GO:1990904;GO:0043232;GO:0005623;GO:0030529;GO:0043226;GO:0022627;GO:0005737;GO:0044445;GO:0032991;GO:0005622;GO:0044446;GO:0044391;GO:0005840;GO:0005829;GO:0044464;GO:0043229;GO:0005575;GO:0044444;GO:0043228;GO:0044424;GO:0044422; cytosolic ribosome;small ribosomal subunit;ribonucleoprotein complex;intracellular non-membrane-bounded organelle;cell;intracellular ribonucleoprotein complex;organelle;cytosolic small ribosomal subunit;cytoplasm;cytosolic part;macromolecular complex;intracellular;intracellular organelle part;ribosomal subunit;ribosome;cytosol;cell part;intracellular organelle;cellular_component;cytoplasmic part;non-membrane-bounded organelle;intracellular part;organelle part; 6;5;3;4;2;4;2;6;4;5;2;3;3;4;5;5;2;3;1;4;3;3;2; GO:1901363;GO:0003674;GO:0005198;GO:0003735;GO:0003676;GO:0019843;GO:0003723;GO:0097159;GO:0005488; heterocyclic compound binding;molecular_function;structural molecule activity;structural constituent of ribosome;nucleic acid binding;rRNA binding;RNA binding;organic cyclic compound binding;binding; 3;1;2;3;4;6;5;3;2; K02987 map03010; Ribosome; IPR018199;IPR002942;IPR013845;IPR032277;IPR013843;IPR005824;IPR000876; Ribosomal protein S4e, N-terminal, conserved site;RNA-binding S4 domain;Ribosomal protein S4e, central region;40S ribosomal protein S4, C-terminal domain;Ribosomal protein S4e, N-terminal;KOW;Ribosomal protein S4e; cytosol Hs20373177 538.0 J [J] Translation, ribosomal structure and biogenesis; Q9BQS7 Hephaestin OS=Homo sapiens OX=9606 GN=HEPH PE=1 SV=3 - [HEPH_HUMAN] 0.969 0.917 0.809 1.248 1.287 1.165 1.056706652 nan 0.96969697 nan 0.882224646 nan 0.905205905 nan GO:0000041;GO:0050801;GO:0006825;GO:0006826;GO:0042592;GO:0055072;GO:0055076;GO:0098771;GO:0044699;GO:0046916;GO:0065007;GO:0065008;GO:0019725;GO:0030001;GO:0006810;GO:0006879;GO:0006875;GO:0006812;GO:0006811;GO:0009987;GO:0006873;GO:0044765;GO:0044763;GO:0030003;GO:0055065;GO:0055080;GO:0055082;GO:0051234;GO:0051179;GO:1902578;GO:0055085;GO:0048878;GO:0008150; transition metal ion transport;ion homeostasis;copper ion transport;iron ion transport;homeostatic process;iron ion homeostasis;transition metal ion homeostasis;inorganic ion homeostasis;single-organism process;cellular transition metal ion homeostasis;biological regulation;regulation of biological quality;cellular homeostasis;metal ion transport;transport;cellular iron ion homeostasis;cellular metal ion homeostasis;cation transport;ion transport;cellular process;cellular ion homeostasis;single-organism transport;single-organism cellular process;cellular cation homeostasis;metal ion homeostasis;cation homeostasis;cellular chemical homeostasis;establishment of localization;localization;single-organism localization;transmembrane transport;chemical homeostasis;biological_process; 8;6;9;9;4;10;9;7;2;9;2;3;4;7;4;10;8;6;5;2;6;4;3;7;8;7;5;3;2;3;4;5;1; GO:0098590;GO:0005622;GO:0005737;GO:0016021;GO:0016020;GO:0031224;GO:0005886;GO:0044425;GO:0044459;GO:0098589;GO:0048471;GO:0016323;GO:0044464;GO:0005623;GO:0005575;GO:0044444;GO:0071944;GO:0044424;GO:0098805; plasma membrane region;intracellular;cytoplasm;integral component of membrane;membrane;intrinsic component of membrane;plasma membrane;membrane part;plasma membrane part;membrane region;perinuclear region of cytoplasm;basolateral plasma membrane;cell part;cell;cellular_component;cytoplasmic part;cell periphery;intracellular part;whole membrane; 4;3;4;4;2;3;3;2;3;3;5;4;2;2;1;4;3;3;3; GO:0003674;GO:0005488;GO:0016491;GO:0043169;GO:0016722;GO:0046914;GO:0004322;GO:0043167;GO:0005506;GO:0005507;GO:0008198;GO:0003824;GO:0016724;GO:0046872; molecular_function;binding;oxidoreductase activity;cation binding;oxidoreductase activity, oxidizing metal ions;transition metal ion binding;ferroxidase activity;ion binding;iron ion binding;copper ion binding;ferrous iron binding;catalytic activity;oxidoreductase activity, oxidizing metal ions, oxygen as acceptor;metal ion binding; 1;2;3;4;4;6;6;3;7;7;8;2;5;5; K14735 map00860;map04978; Porphyrin and chlorophyll metabolism;Mineral absorption; IPR027154;IPR011707;IPR011706;IPR033138;IPR008972;IPR002355; Hephaestin;Multicopper oxidase, type 3;Multicopper oxidase, type 2;Multicopper oxidases, conserved site;Cupredoxin;Multicopper oxidase, copper-binding site; endoplasmic reticulum Hs21166385 2427.0 Q [Q] Secondary metabolites biosynthesis, transport and catabolism; P49411 Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=2 - [EFTU_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0007005;GO:0044710;GO:0044711;GO:0043043;GO:1901564;GO:0019538;GO:0006807;GO:0043170;GO:1901576;GO:0044260;GO:0016043;GO:0071840;GO:0032543;GO:0008150;GO:0008152;GO:0044271;GO:0044249;GO:0034641;GO:0034645;GO:1901566;GO:0044699;GO:0009987;GO:0043604;GO:0043603;GO:0071704;GO:0010467;GO:0070125;GO:0044267;GO:0009058;GO:0009059;GO:0044763;GO:0006518;GO:0006996;GO:0044238;GO:0044237;GO:1902589;GO:0006414;GO:0006412; mitochondrion organization;single-organism metabolic process;single-organism biosynthetic process;peptide biosynthetic process;organonitrogen compound metabolic process;protein metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;cellular component organization or biogenesis;mitochondrial translation;biological_process;metabolic process;cellular nitrogen compound biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organonitrogen compound biosynthetic process;single-organism process;cellular process;amide biosynthetic process;cellular amide metabolic process;organic substance metabolic process;gene expression;mitochondrial translational elongation;cellular protein metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;peptide metabolic process;organelle organization;primary metabolic process;cellular metabolic process;single-organism organelle organization;translational elongation;translation; 5;3;4;6;4;4;3;4;4;4;3;2;5;1;2;5;4;4;5;5;2;2;6;5;3;5;6;5;3;5;3;5;4;3;3;4;6;6; GO:0031974;GO:0031982;GO:0016020;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0044429;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0009295;GO:0005737;GO:0044446;GO:0044444;GO:0042645;GO:0005739;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0070062;GO:0005759;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;vesicle;membrane;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;nucleoid;cytoplasm;intracellular organelle part;cytoplasmic part;mitochondrial nucleoid;mitochondrion;cell part;cell;intracellular;non-membrane-bounded organelle;extracellular exosome;mitochondrial matrix;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;4;2;3;4;4;3;4;3;2;2;3;3;2;2;4;3;4;3;5;2;2;3;3;4;5;3;1;4;2; GO:1901363;GO:0000166;GO:0003924;GO:0016818;GO:0008135;GO:0016817;GO:0097367;GO:0016787;GO:0003674;GO:0005488;GO:0003676;GO:1901265;GO:0032549;GO:0017076;GO:0005525;GO:0003824;GO:0097159;GO:0016462;GO:0032555;GO:0003746;GO:0032550;GO:0032553;GO:0035639;GO:0043168;GO:0043167;GO:0032561;GO:0044822;GO:0003723;GO:0001883;GO:0001882;GO:0019001;GO:0017111;GO:0036094; heterocyclic compound binding;nucleotide binding;GTPase activity;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;translation factor activity, RNA binding;hydrolase activity, acting on acid anhydrides;carbohydrate derivative binding;hydrolase activity;molecular_function;binding;nucleic acid binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;GTP binding;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;purine ribonucleotide binding;translation elongation factor activity;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;anion binding;ion binding;guanyl ribonucleotide binding;poly(A) RNA binding;RNA binding;purine nucleoside binding;nucleoside binding;guanyl nucleotide binding;nucleoside-triphosphatase activity;small molecule binding; 3;4;8;5;6;4;3;3;1;2;4;4;5;5;6;2;3;6;5;7;6;4;5;4;3;6;6;5;5;4;6;7;3; K02358 IPR000795;IPR004541;IPR033720;IPR004161;IPR004160;IPR009001;IPR009000;IPR027417;IPR031157; Transcription factor, GTP-binding domain;Translation elongation factor EFTu/EF1A, bacterial/organelle;Elongation factor Tu, domain 2;Translation elongation factor EFTu-like, domain 2;Translation elongation factor EFTu/EF1A, C-terminal;Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal;Translation protein, beta-barrel domain;P-loop containing nucleoside triphosphate hydrolase;Tr-type G domain, conserved site; mitochondria Hs21359837 920.0 J [J] Translation, ribosomal structure and biogenesis; Q9Y2P5 Bile acyl-CoA synthetase OS=Homo sapiens OX=9606 GN=SLC27A5 PE=1 SV=1 - [S27A5_HUMAN] 1.17 1.152 0.679 1.201 1.119 0.893 1.015625 nan 1.073279714 nan 0.589409722 nan 0.798033959 nan GO:0015721;GO:0006820;GO:0044281;GO:0044283;GO:1901362;GO:0008206;GO:1901360;GO:0044710;GO:0044711;GO:0033036;GO:0015718;GO:0015849;GO:0015711;GO:1902224;GO:0032787;GO:0043436;GO:0046486;GO:0010876;GO:0044249;GO:0016053;GO:1902001;GO:0015850;GO:0015911;GO:0015908;GO:1901576;GO:0015909;GO:0006629;GO:0006811;GO:0006810;GO:0008150;GO:0008152;GO:0000038;GO:0051234;GO:0046394;GO:0009058;GO:0006694;GO:0006699;GO:1901617;GO:1901615;GO:0006631;GO:0006869;GO:0006639;GO:0006638;GO:1903825;GO:0044699;GO:0006642;GO:0008610;GO:0006641;GO:0009987;GO:0044255;GO:0055085;GO:0008202;GO:0006082;GO:1905039;GO:0019752;GO:0072330;GO:0071704;GO:0046950;GO:0071702;GO:0046951;GO:0034220;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0046942;GO:0044238;GO:0044237;GO:0098656; bile acid and bile salt transport;anion transport;small molecule metabolic process;small molecule biosynthetic process;organic cyclic compound biosynthetic process;bile acid metabolic process;organic cyclic compound metabolic process;single-organism metabolic process;single-organism biosynthetic process;macromolecule localization;monocarboxylic acid transport;organic acid transport;organic anion transport;ketone body metabolic process;monocarboxylic acid metabolic process;oxoacid metabolic process;glycerolipid metabolic process;lipid localization;cellular biosynthetic process;organic acid biosynthetic process;fatty acid transmembrane transport;organic hydroxy compound transport;plasma membrane long-chain fatty acid transport;fatty acid transport;organic substance biosynthetic process;long-chain fatty acid transport;lipid metabolic process;ion transport;transport;biological_process;metabolic process;very long-chain fatty acid metabolic process;establishment of localization;carboxylic acid biosynthetic process;biosynthetic process;steroid biosynthetic process;bile acid biosynthetic process;organic hydroxy compound biosynthetic process;organic hydroxy compound metabolic process;fatty acid metabolic process;lipid transport;acylglycerol metabolic process;neutral lipid metabolic process;organic acid transmembrane transport;single-organism process;triglyceride mobilization;lipid biosynthetic process;triglyceride metabolic process;cellular process;cellular lipid metabolic process;transmembrane transport;steroid metabolic process;organic acid metabolic process;carboxylic acid transmembrane transport;carboxylic acid metabolic process;monocarboxylic acid biosynthetic process;organic substance metabolic process;cellular ketone body metabolic process;organic substance transport;ketone body biosynthetic process;ion transmembrane transport;single-organism transport;single-organism cellular process;localization;single-organism localization;carboxylic acid transport;primary metabolic process;cellular metabolic process;anion transmembrane transport; 6;6;4;5;5;5;4;3;4;3;7;5;6;4;7;5;5;4;4;5;7;5;8;6;4;7;4;5;4;1;2;6;3;6;3;6;6;5;4;5;5;6;5;5;2;8;5;7;2;4;4;5;4;6;6;7;3;4;5;5;5;4;3;2;3;6;3;3;6; GO:0005783;GO:0005789;GO:0016021;GO:0016020;GO:0098588;GO:0098589;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043229;GO:0030176;GO:0043227;GO:0043226;GO:0044432;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0042175;GO:0031301;GO:0031300;GO:0031227;GO:0005737;GO:0031090;GO:0045178;GO:0009925;GO:0044459;GO:0016323;GO:0044464;GO:0005623;GO:0005622;GO:0071944;GO:0098805;GO:0005886;GO:0032991;GO:0005575; endoplasmic reticulum;endoplasmic reticulum membrane;integral component of membrane;membrane;bounding membrane of organelle;membrane region;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;organelle part;plasma membrane region;intracellular organelle;integral component of endoplasmic reticulum membrane;membrane-bounded organelle;organelle;endoplasmic reticulum part;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;integral component of organelle membrane;intrinsic component of organelle membrane;intrinsic component of endoplasmic reticulum membrane;cytoplasm;organelle membrane;basal part of cell;basal plasma membrane;plasma membrane part;basolateral plasma membrane;cell part;cell;intracellular;cell periphery;whole membrane;plasma membrane;macromolecular complex;cellular_component; 4;3;4;2;4;3;3;4;3;2;2;4;3;4;3;2;4;3;3;3;4;3;4;3;4;4;3;3;4;3;4;2;2;3;3;3;3;2;1; GO:0015645;GO:0000166;GO:0005319;GO:0097367;GO:0015245;GO:0031957;GO:0003674;GO:0005488;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0003824;GO:0032555;GO:0036094;GO:0022892;GO:0097159;GO:0032559;GO:0032553;GO:0035639;GO:0043167;GO:0016877;GO:0005215;GO:0030554;GO:0001883;GO:0001882;GO:0004467;GO:0016878;GO:0047747;GO:0016874;GO:0032550; fatty acid ligase activity;nucleotide binding;lipid transporter activity;carbohydrate derivative binding;fatty acid transporter activity;very long-chain fatty acid-CoA ligase activity;molecular_function;binding;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;catalytic activity;purine ribonucleotide binding;small molecule binding;substrate-specific transporter activity;organic cyclic compound binding;adenyl ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;ligase activity, forming carbon-sulfur bonds;transporter activity;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;long-chain fatty acid-CoA ligase activity;acid-thiol ligase activity;cholate-CoA ligase activity;ligase activity;purine ribonucleoside binding; 5;4;4;3;5;6;1;2;4;3;5;5;6;4;2;5;3;3;3;6;4;5;3;4;2;6;5;4;6;5;6;3;6; K08748 map00120;map01100;map03320;map04931;map04976; Primary bile acid biosynthesis;Metabolic pathways;PPAR signaling pathway;Insulin resistance;Bile secretion; IPR000873;IPR020845;IPR030302;IPR025110; AMP-dependent synthetase/ligase;AMP-binding, conserved site;Fatty acid transport protein 5;AMP-binding enzyme, C-terminal domain; plasma membrane Hs13325057 1394.0 I [I] Lipid transport and metabolism; A0A1B0GW35 Exocyst complex component 1-like OS=Homo sapiens OX=9606 GN=EXOC1L PE=2 SV=1 - [EXC1L_HUMAN] 1.829 0.963 0.635 1.15 0.853 0.376 1.899273105 0.017449723 1.348182884 0.338280227 0.659397715 0.100018244 0.440797186 nan GO:0060341;GO:0051047;GO:0051049;GO:1903532;GO:0007165;GO:0032940;GO:0023052;GO:1903530;GO:0035556;GO:0051222;GO:0051223;GO:0050789;GO:0044699;GO:0032880;GO:1904951;GO:0050708;GO:0051046;GO:0008104;GO:0009306;GO:0065007;GO:0048017;GO:0032879;GO:0071702;GO:0048518;GO:0033036;GO:0070201;GO:0006810;GO:0051050;GO:0051716;GO:0050794;GO:0045184;GO:0015031;GO:0044765;GO:0044763;GO:0006887;GO:0007154;GO:0008150;GO:0051234;GO:0048015;GO:0051179;GO:1902578;GO:0051641;GO:0044700;GO:0046903;GO:0016192;GO:0050714;GO:0050896;GO:0009987;GO:0048522; regulation of cellular localization;positive regulation of secretion;regulation of transport;positive regulation of secretion by cell;signal transduction;secretion by cell;signaling;regulation of secretion by cell;intracellular signal transduction;positive regulation of protein transport;regulation of protein transport;regulation of biological process;single-organism process;regulation of protein localization;positive regulation of establishment of protein localization;regulation of protein secretion;regulation of secretion;protein localization;protein secretion;biological regulation;inositol lipid-mediated signaling;regulation of localization;organic substance transport;positive regulation of biological process;macromolecule localization;regulation of establishment of protein localization;transport;positive regulation of transport;cellular response to stimulus;regulation of cellular process;establishment of protein localization;protein transport;single-organism transport;single-organism cellular process;exocytosis;cell communication;biological_process;establishment of localization;phosphatidylinositol-mediated signaling;localization;single-organism localization;cellular localization;single organism signaling;secretion;vesicle-mediated transport;positive regulation of protein secretion;response to stimulus;cellular process;positive regulation of cellular process; 4;4;4;4;4;4;2;5;5;4;5;2;2;4;3;6;5;4;5;2;6;3;5;2;3;5;4;3;3;3;4;5;4;3;5;4;1;3;7;2;3;3;3;5;5;5;2;2;3; GO:0098590;GO:0098592;GO:0009898;GO:0071944;GO:0098552;GO:0005737;GO:0045177;GO:0098805;GO:0016020;GO:0044459;GO:0016324;GO:0098562;GO:0098589;GO:0005886;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424;GO:0044425; plasma membrane region;cytoplasmic side of apical plasma membrane;cytoplasmic side of plasma membrane;cell periphery;side of membrane;cytoplasm;apical part of cell;whole membrane;membrane;plasma membrane part;apical plasma membrane;cytoplasmic side of membrane;membrane region;plasma membrane;cell part;cell;intracellular;cellular_component;intracellular part;membrane part; 4;5;4;3;3;4;3;3;2;3;4;4;3;3;2;2;3;1;3;2; IPR028258; Exocyst complex component Sec3, PIP2-binding N-terminal domain; cytosol Hs22042501 74.3 U [U] Intracellular trafficking, secretion, and vesicular transport; P14151 L-selectin OS=Homo sapiens OX=9606 GN=SELL PE=1 SV=2 - [LYAM1_HUMAN] 1.023 0.907 1.096 1.048 0.986 0.912 1.127894157 0.818333936 1.062880325 0.591856532 1.208379272 0.453445053 0.92494929 0.628243245 GO:0007599;GO:0006955;GO:0048583;GO:0006928;GO:0007596;GO:0050900;GO:0014074;GO:0050789;GO:0044699;GO:0009719;GO:0002376;GO:0009611;GO:0010033;GO:0014070;GO:0002682;GO:0065007;GO:0065008;GO:0046683;GO:1901700;GO:0032501;GO:0050878;GO:0009987;GO:0042060;GO:0016477;GO:0006950;GO:0050817;GO:0008150;GO:0010243;GO:0007155;GO:0042221;GO:0051179;GO:0040011;GO:0050776;GO:0044707;GO:0048870;GO:0022610;GO:0050896;GO:0044763;GO:0051674;GO:0033198;GO:1901698; hemostasis;immune response;regulation of response to stimulus;movement of cell or subcellular component;blood coagulation;leukocyte migration;response to purine-containing compound;regulation of biological process;single-organism process;response to endogenous stimulus;immune system process;response to wounding;response to organic substance;response to organic cyclic compound;regulation of immune system process;biological regulation;regulation of biological quality;response to organophosphorus;response to oxygen-containing compound;multicellular organismal process;regulation of body fluid levels;cellular process;wound healing;cell migration;response to stress;coagulation;biological_process;response to organonitrogen compound;cell adhesion;response to chemical;localization;locomotion;regulation of immune response;single-multicellular organism process;cell motility;biological adhesion;response to stimulus;single-organism cellular process;localization of cell;response to ATP;response to nitrogen compound; 5;3;3;4;5;3;5;2;2;3;2;4;4;5;3;2;3;5;4;2;4;2;5;4;3;4;1;4;3;3;2;2;4;3;3;2;2;3;3;5;4; GO:0009897;GO:0071944;GO:0098552;GO:0031226;GO:0016021;GO:0016020;GO:0031224;GO:0044459;GO:0009986;GO:0005887;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044425; external side of plasma membrane;cell periphery;side of membrane;intrinsic component of plasma membrane;integral component of membrane;membrane;intrinsic component of membrane;plasma membrane part;cell surface;integral component of plasma membrane;plasma membrane;cell part;cell;cellular_component;membrane part; 4;3;3;4;4;2;3;3;3;4;3;2;2;1;2; GO:0030246;GO:0019899;GO:0003674;GO:0005488;GO:0043167;GO:0005539;GO:0043208;GO:1901681;GO:0008201;GO:0002020;GO:0008289;GO:0046625;GO:0097367;GO:0043168;GO:0005515;GO:0051861; carbohydrate binding;enzyme binding;molecular_function;binding;ion binding;glycosaminoglycan binding;glycosphingolipid binding;sulfur compound binding;heparin binding;protease binding;lipid binding;sphingolipid binding;carbohydrate derivative binding;anion binding;protein binding;glycolipid binding; 3;4;1;2;3;4;5;3;4;5;3;4;3;4;3;4; K06495 map04514; Cell adhesion molecules (CAMs); IPR016186;IPR002396;IPR033991;IPR000436;IPR016348;IPR018378;IPR000742;IPR001304;IPR016187;IPR013032; C-type lectin-like/link domain;Selectin superfamily;Selectin, C-type lectin-like domain;Sushi/SCR/CCP domain;L-selectin;C-type lectin, conserved site;EGF-like domain;C-type lectin-like;C-type lectin fold;EGF-like, conserved site; plasma membrane Hs4506875 775.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; O00187 Mannan-binding lectin serine protease 2 OS=Homo sapiens OX=9606 GN=MASP2 PE=1 SV=4 - [MASP2_HUMAN] 1.067 1.009 0.937 1.023 0.985 1.544 1.057482656 0.705370847 1.03857868 0.694378504 0.92864222 0.624985921 1.56751269 0.120742726 GO:0048584;GO:0048583;GO:0044699;GO:0044710;GO:0006959;GO:0072376;GO:0002443;GO:0050789;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:0002253;GO:0019724;GO:0045087;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0001867;GO:0044238;GO:0050776;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0002455;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002252;GO:0006958;GO:0006956; positive regulation of response to stimulus;regulation of response to stimulus;single-organism process;single-organism metabolic process;humoral immune response;protein activation cascade;leukocyte mediated immunity;regulation of biological process;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;activation of immune response;B cell mediated immunity;innate immune response;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;complement activation, lectin pathway;primary metabolic process;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;humoral immune response mediated by circulating immunoglobulin;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;immune effector process;complement activation, classical pathway;complement activation; 3;3;2;3;4;3;4;2;3;3;3;2;2;3;6;4;4;3;7;1;2;3;5;3;4;5;5;4;2;5;4;4;2;4;3;5;4; GO:0043227;GO:0043226;GO:0005575;GO:0070062;GO:0005576;GO:1903561;GO:0031982;GO:0043230;GO:0044421; membrane-bounded organelle;organelle;cellular_component;extracellular exosome;extracellular region;extracellular vesicle;vesicle;extracellular organelle;extracellular region part; 3;2;1;4;2;3;4;3;2; GO:0004252;GO:0004175;GO:0048306;GO:0043169;GO:0003674;GO:0005488;GO:0008233;GO:0043167;GO:0008236;GO:0005509;GO:0046872;GO:0001846;GO:0016787;GO:0001848;GO:0017171;GO:0003824;GO:0070011;GO:0005515;GO:0001855; serine-type endopeptidase activity;endopeptidase activity;calcium-dependent protein binding;cation binding;molecular_function;binding;peptidase activity;ion binding;serine-type peptidase activity;calcium ion binding;metal ion binding;opsonin binding;hydrolase activity;complement binding;serine hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides;protein binding;complement component C4b binding; 6;6;4;4;1;2;4;3;5;6;5;4;3;4;4;2;5;3;5; K03993 map04610;map05150; Complement and coagulation cascades;Staphylococcus aureus infection; IPR000152;IPR018097;IPR001254;IPR000859;IPR000436;IPR009003;IPR000742;IPR001314;IPR001881;IPR013032;IPR033116; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;CUB domain;Sushi/SCR/CCP domain;Peptidase S1, PA clan;EGF-like domain;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;EGF-like, conserved site;Serine proteases, trypsin family, serine active site; extracellular Hs21264363 1427.0 E [E] Amino acid transport and metabolism; Q9HC38 Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1 - [GLOD4_HUMAN] 1.127 1.171 0.794 0.871 1.368 0.565 0.962425278 nan 0.636695906 nan 0.678052946 nan 0.413011696 nan GO:0005737;GO:0005622;GO:0043230;GO:0070062;GO:0044464;GO:0043229;GO:0005739;GO:0044421;GO:0005575;GO:0044444;GO:0005576;GO:0005623;GO:0043231;GO:0044424;GO:1903561;GO:0043227;GO:0043226;GO:0031982; cytoplasm;intracellular;extracellular organelle;extracellular exosome;cell part;intracellular organelle;mitochondrion;extracellular region part;cellular_component;cytoplasmic part;extracellular region;cell;intracellular membrane-bounded organelle;intracellular part;extracellular vesicle;membrane-bounded organelle;organelle;vesicle; 4;3;3;4;2;3;5;2;1;4;2;2;4;3;3;3;2;4; IPR029068; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; mitochondria Hs7705646 566.0 G [G] Carbohydrate transport and metabolism; Q99590 Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2 - [SCAFB_HUMAN] 1.742 0.655 0.8 1.413 0.627 1.013 2.659541985 nan 2.253588517 nan 1.221374046 nan 1.615629984 nan GO:0022607;GO:0000245;GO:0043933;GO:0090304;GO:0034641;GO:0006807;GO:0044237;GO:0034622;GO:0071840;GO:0006139;GO:0071826;GO:0044260;GO:0016043;GO:0065003;GO:0071704;GO:0010467;GO:0022618;GO:1901360;GO:0022613;GO:0008380;GO:0016071;GO:0009987;GO:0006725;GO:0000375;GO:0000377;GO:0008150;GO:0008152;GO:0046483;GO:0016070;GO:0044238;GO:0000398;GO:0043170;GO:0044085;GO:0006396;GO:0006397; cellular component assembly;spliceosomal complex assembly;macromolecular complex subunit organization;nucleic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecular complex assembly;cellular component organization or biogenesis;nucleobase-containing compound metabolic process;ribonucleoprotein complex subunit organization;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;organic substance metabolic process;gene expression;ribonucleoprotein complex assembly;organic cyclic compound metabolic process;ribonucleoprotein complex biogenesis;RNA splicing;mRNA metabolic process;cellular process;cellular aromatic compound metabolic process;RNA splicing, via transesterification reactions;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;biological_process;metabolic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;mRNA splicing, via spliceosome;macromolecule metabolic process;cellular component biogenesis;RNA processing;mRNA processing; 4;6;4;5;4;3;3;6;2;4;5;4;3;5;3;5;5;4;4;7;6;2;4;8;9;1;2;4;5;3;8;4;3;6;7; GO:0031974;GO:0005622;GO:0043227;GO:0043226;GO:0005623;GO:0005730;GO:0005634;GO:0005654;GO:0005575;GO:0043228;GO:0043231;GO:0043232;GO:0043233;GO:0031981;GO:0044464;GO:0043229;GO:0044446;GO:0070013;GO:0044428;GO:0044422;GO:0044424; membrane-enclosed lumen;intracellular;membrane-bounded organelle;organelle;cell;nucleolus;nucleus;nucleoplasm;cellular_component;non-membrane-bounded organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear lumen;cell part;intracellular organelle;intracellular organelle part;intracellular organelle lumen;nuclear part;organelle part;intracellular part; 2;3;3;2;2;5;5;5;1;3;4;4;3;5;2;3;3;4;4;2;3; GO:0005488;GO:1901363;GO:0043169;GO:0003674;GO:0003676;GO:0008270;GO:0043167;GO:0046872;GO:0003723;GO:0044822;GO:0046914;GO:0097159; binding;heterocyclic compound binding;cation binding;molecular_function;nucleic acid binding;zinc ion binding;ion binding;metal ion binding;RNA binding;poly(A) RNA binding;transition metal ion binding;organic cyclic compound binding; 2;3;4;1;4;7;3;5;5;6;6;3; IPR017907;IPR001841;IPR013083; Zinc finger, RING-type, conserved site;Zinc finger, RING-type;Zinc finger, RING/FYVE/PHD-type; nucleus Hs4759172 2344.0 R [R] General function prediction only; Q96Q91 Anion exchange protein 4 OS=Homo sapiens OX=9606 GN=SLC4A9 PE=2 SV=2 - [B3A4_HUMAN] 0.954 1.048 0.974 1.08 1.035 1.445 0.910305344 nan 1.043478261 nan 0.929389313 nan 1.396135266 nan GO:0015701;GO:0006820;GO:0044699;GO:0051179;GO:0071702;GO:0009987;GO:0006811;GO:0006810;GO:0015711;GO:0034220;GO:0044765;GO:0044763;GO:0051234;GO:0055085;GO:1902578;GO:0098656;GO:0008150; bicarbonate transport;anion transport;single-organism process;localization;organic substance transport;cellular process;ion transport;transport;organic anion transport;ion transmembrane transport;single-organism transport;single-organism cellular process;establishment of localization;transmembrane transport;single-organism localization;anion transmembrane transport;biological_process; 7;6;2;2;5;2;5;4;6;5;4;3;3;4;3;6;1; GO:0098590;GO:0016021;GO:0071944;GO:0005575;GO:0045177;GO:0016020;GO:0044425;GO:0031224;GO:0044459;GO:0098589;GO:0016323;GO:0005886;GO:0044464;GO:0005623;GO:0098805; plasma membrane region;integral component of membrane;cell periphery;cellular_component;apical part of cell;membrane;membrane part;intrinsic component of membrane;plasma membrane part;membrane region;basolateral plasma membrane;plasma membrane;cell part;cell;whole membrane; 4;4;3;1;3;2;2;3;3;3;4;3;2;2;3; GO:0003674;GO:0008509;GO:0005452;GO:0015103;GO:0022804;GO:0015291;GO:0005215;GO:0022891;GO:0022892;GO:0015075;GO:0022857; molecular_function;anion transmembrane transporter activity;inorganic anion exchanger activity;inorganic anion transmembrane transporter activity;active transmembrane transporter activity;secondary active transmembrane transporter activity;transporter activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;transmembrane transporter activity; 1;6;6;7;4;5;2;4;3;5;3; K13860 IPR003020;IPR013769;IPR011531;IPR003024;IPR016152; Bicarbonate transporter, eukaryotic;Band 3 cytoplasmic domain;Bicarbonate transporter, C-terminal;Sodium bicarbonate cotransporter;Phosphotransferase/anion transporter; plasma membrane Hs22049645 1984.0 P [P] Inorganic ion transport and metabolism; P81605 Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2 - [DCD_HUMAN] 0.914 0.829 0.948 0.964 1.253 1.811 1.102533173 0.177250072 0.769353551 0.37889832 1.143546442 0.517435823 1.445331205 0.29025558 GO:0043207;GO:0044364;GO:0009617;GO:0065007;GO:0001906;GO:0065008;GO:0051704;GO:0006952;GO:0006950;GO:0008150;GO:0009607;GO:0051707;GO:0050832;GO:0009605;GO:0050896;GO:0031640;GO:0035821;GO:0009620;GO:0098542;GO:0042742; response to external biotic stimulus;disruption of cells of other organism;response to bacterium;biological regulation;cell killing;regulation of biological quality;multi-organism process;defense response;response to stress;biological_process;response to biotic stimulus;response to other organism;defense response to fungus;response to external stimulus;response to stimulus;killing of cells of other organism;modification of morphology or physiology of other organism;response to fungus;defense response to other organism;defense response to bacterium; 4;4;4;2;2;3;2;4;3;1;3;3;5;3;2;3;3;4;4;5; GO:0043227;GO:0070062;GO:0005615;GO:0043226;GO:1903561;GO:0031982;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;extracellular exosome;extracellular space;organelle;extracellular vesicle;vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;4;3;2;3;4;3;1;2;2; GO:0003674;GO:0005488;GO:0003676;GO:0008233;GO:1901363;GO:0016787;GO:0044822;GO:0003824;GO:0097159;GO:0003723; molecular_function;binding;nucleic acid binding;peptidase activity;heterocyclic compound binding;hydrolase activity;poly(A) RNA binding;catalytic activity;organic cyclic compound binding;RNA binding; 1;2;4;4;3;3;6;2;3;5; IPR028130; Dermcidin; extracellular Q9NZP8 Complement C1r subcomponent-like protein OS=Homo sapiens OX=9606 GN=C1RL PE=1 SV=2 - [C1RL_HUMAN] 0.856 0.884 1.405 0.889 0.878 1.219 0.968325792 0.563332224 1.012528474 0.31423907 1.589366516 0.016647494 1.388382688 0.038120194 GO:0019724;GO:0048584;GO:0048583;GO:0006959;GO:0002455;GO:0050789;GO:0044699;GO:0044710;GO:0016064;GO:0072376;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:0045087;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0002443;GO:0044238;GO:0050776;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0006956; B cell mediated immunity;positive regulation of response to stimulus;regulation of response to stimulus;humoral immune response;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;single-organism metabolic process;immunoglobulin mediated immune response;protein activation cascade;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;innate immune response;defense response;response to stress;biological_process;metabolic process;immune response;complement activation, classical pathway;leukocyte mediated immunity;primary metabolic process;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;complement activation; 6;3;3;4;5;2;2;3;7;3;3;3;3;2;2;4;4;3;1;2;3;5;4;3;4;5;5;4;2;4;4;2;4;3;3;4; GO:0043227;GO:0005575;GO:0070062;GO:0005615;GO:0043226;GO:0005576;GO:0031982;GO:0043230;GO:1903561;GO:0044421; membrane-bounded organelle;cellular_component;extracellular exosome;extracellular space;organelle;extracellular region;vesicle;extracellular organelle;extracellular vesicle;extracellular region part; 3;1;4;3;2;2;4;3;3;2; GO:0004252;GO:0004175;GO:0003674;GO:0008236;GO:0016787;GO:0017171;GO:0003824;GO:0070011;GO:0008233; serine-type endopeptidase activity;endopeptidase activity;molecular_function;serine-type peptidase activity;hydrolase activity;serine hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides;peptidase activity; 6;6;1;5;3;4;2;5;4; IPR001254;IPR000859;IPR000436;IPR009003;IPR001314;IPR033116; Serine proteases, trypsin domain;CUB domain;Sushi/SCR/CCP domain;Peptidase S1, PA clan;Peptidase S1A, chymotrypsin family;Serine proteases, trypsin family, serine active site; mitochondria Hs7706083 1012.0 E [E] Amino acid transport and metabolism; Q8N972 Zinc finger protein 709 OS=Homo sapiens OX=9606 GN=ZNF709 PE=2 SV=1 - [ZN709_HUMAN] 0.917 0.843 1.585 0.983 0.824 0.708 1.087781732 nan 1.192961165 nan 1.880189798 nan 0.859223301 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:1901362;GO:0050789;GO:0097659;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:1901360;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0044237;GO:0043170;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;organic cyclic compound biosynthetic process;regulation of biological process;nucleic acid-templated transcription;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;organic cyclic compound metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;cellular metabolic process;macromolecule metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;5;5;2;7;6;4;4;6;3;5;2;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;3;4;6;5;6;5; GO:0005623;GO:0005622;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005575;GO:0044424; cell;intracellular;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cellular_component;intracellular part; 2;3;3;5;2;4;2;3;1;3; GO:0043169;GO:0003674;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;DNA binding;metal ion binding;nucleic acid binding;ion binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;5;5;4;3;3;3;2; K09228 IPR013087;IPR001909; Zinc finger C2H2-type;Krueppel-associated box; nucleus Hs18601279 1288.0 R [R] General function prediction only; A0A075B6K5 Immunoglobulin lambda variable 3-9 OS=Homo sapiens OX=9606 GN=IGLV3-9 PE=3 SV=1 - [LV39_HUMAN] 1.124 0.924 1.03 0.989 0.928 0.916 1.216450216 0.162263769 1.065732759 0.523230101 1.114718615 0.026284415 0.987068966 0.663145392 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular A0A075B6K4 Immunoglobulin lambda variable 3-10 OS=Homo sapiens OX=9606 GN=IGLV3-10 PE=3 SV=2 - [LV310_HUMAN] 0.939 1.096 1.184 0.835 1.108 0.729 0.856751825 0.00666822 0.753610108 0.001697336 1.080291971 0.009935481 0.657942238 0.013148863 IPR003599;IPR007110;IPR013783;IPR013106; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular Q5XKP0 MICOS complex subunit MIC13 OS=Homo sapiens OX=9606 GN=MICOS13 PE=1 SV=1 - [MIC13_HUMAN] 0.806 1.429 1.102 1.061 0.861 0.842 0.564030791 nan 1.232288037 nan 0.771168649 nan 0.977932636 nan GO:0044802;GO:0042407;GO:0071840;GO:0007005;GO:0016043;GO:0007007;GO:0044699;GO:0006996;GO:0008150;GO:0009987;GO:0044763;GO:1902589;GO:0061024;GO:0007006; single-organism membrane organization;cristae formation;cellular component organization or biogenesis;mitochondrion organization;cellular component organization;inner mitochondrial membrane organization;single-organism process;organelle organization;biological_process;cellular process;single-organism cellular process;single-organism organelle organization;membrane organization;mitochondrial membrane organization; 4;7;2;5;3;6;2;4;1;2;3;4;4;5; GO:0019866;GO:0098573;GO:0031975;GO:0044284;GO:0031304;GO:0043229;GO:0031301;GO:0031300;GO:0032592;GO:0043227;GO:0043226;GO:0031224;GO:0005737;GO:0044446;GO:0031090;GO:0098796;GO:0016021;GO:0016020;GO:0044444;GO:0005739;GO:0098800;GO:0044455;GO:0031967;GO:0031966;GO:0061617;GO:0043234;GO:0031305;GO:0032991;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005743;GO:0005740;GO:0044429;GO:0044424;GO:0044425;GO:0044422;GO:0098798; organelle inner membrane;intrinsic component of mitochondrial membrane;envelope;mitochondrial crista junction;intrinsic component of mitochondrial inner membrane;intracellular organelle;integral component of organelle membrane;intrinsic component of organelle membrane;integral component of mitochondrial membrane;membrane-bounded organelle;organelle;intrinsic component of membrane;cytoplasm;intracellular organelle part;organelle membrane;membrane protein complex;integral component of membrane;membrane;cytoplasmic part;mitochondrion;inner mitochondrial membrane protein complex;mitochondrial membrane part;organelle envelope;mitochondrial membrane;MICOS complex;protein complex;integral component of mitochondrial inner membrane;macromolecular complex;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;mitochondrial inner membrane;mitochondrial envelope;mitochondrial part;intracellular part;membrane part;organelle part;mitochondrial protein complex; 4;4;3;4;5;3;4;3;5;3;2;3;4;3;3;3;4;2;4;5;4;3;4;4;5;3;6;2;4;2;2;3;1;5;5;4;3;2;2;4; IPR026769; MICOS complex subunit Mic13; mitochondria Q14116 Interleukin-18 OS=Homo sapiens OX=9606 GN=IL18 PE=1 SV=1 - [IL18_HUMAN] 0.661 0.791 1.882 0.72 0.849 1.246 0.835651075 nan 0.848056537 nan 2.379266751 nan 1.467608952 nan GO:0033157;GO:0051169;GO:0051049;GO:0042033;GO:0032388;GO:0051716;GO:0043207;GO:0000165;GO:0008104;GO:0042325;GO:0042327;GO:0042088;GO:0042089;GO:0009605;GO:0019538;GO:1904589;GO:0042692;GO:0009893;GO:0046651;GO:0051222;GO:0051223;GO:0050789;GO:0006886;GO:0002684;GO:0002682;GO:0070201;GO:0098602;GO:1903649;GO:0098609;GO:0043412;GO:0048869;GO:0032609;GO:0018212;GO:1903827;GO:0014070;GO:0008284;GO:0008283;GO:0050870;GO:0060341;GO:0018108;GO:0022407;GO:0045445;GO:0007275;GO:0022409;GO:0033993;GO:0070661;GO:0070663;GO:0070665;GO:0097696;GO:0006468;GO:0090316;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0050755;GO:0030101;GO:0042509;GO:1901701;GO:0042503;GO:0048856;GO:0006796;GO:0006793;GO:0048523;GO:0048522;GO:0032623;GO:0032620;GO:0034112;GO:0034110;GO:0048771;GO:0031349;GO:0007165;GO:0007166;GO:0031347;GO:0044710;GO:0050729;GO:0045785;GO:0050727;GO:0045661;GO:0045662;GO:0033036;GO:0051050;GO:0009607;GO:0051707;GO:0010033;GO:0042990;GO:0042991;GO:0031503;GO:0031663;GO:1903533;GO:0045321;GO:0010628;GO:0042092;GO:0009653;GO:0042095;GO:0042094;GO:0001568;GO:0042098;GO:0050798;GO:0032814;GO:0032816;GO:0032817;GO:0050793;GO:0032819;GO:0050794;GO:0051239;GO:0051234;GO:0050896;GO:0002694;GO:0046824;GO:0002696;GO:0046822;GO:0010562;GO:0032103;GO:0032101;GO:0001944;GO:0070887;GO:0044699;GO:0032880;GO:0051249;GO:0051240;GO:0051246;GO:0051247;GO:1903039;GO:0001866;GO:0031399;GO:1903034;GO:0001787;GO:1903036;GO:1903037;GO:1901700;GO:1902593;GO:0072594;GO:0071396;GO:0002460;GO:0002237;GO:0033365;GO:0048731;GO:0032660;GO:0016337;GO:0050865;GO:0050867;GO:0050863;GO:0051140;GO:0051142;GO:0051147;GO:0051148;GO:0001525;GO:0035556;GO:0045937;GO:0032616;GO:0070489;GO:0030431;GO:0007267;GO:0042221;GO:0070486;GO:0007260;GO:0044238;GO:0042346;GO:0042345;GO:0042348;GO:0044237;GO:0042253;GO:0090087;GO:0019220;GO:0019222;GO:0032386;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0009966;GO:0009967;GO:0042531;GO:0048514;GO:0032729;GO:0048518;GO:0048519;GO:0032725;GO:0043122;GO:0043123;GO:0042127;GO:0006606;GO:0042129;GO:0006605;GO:0045184;GO:0044700;GO:0044707;GO:0050731;GO:0050730;GO:0002376;GO:0046006;GO:0043170;GO:0023014;GO:0071219;GO:0071216;GO:0048646;GO:0006810;GO:0006952;GO:0006950;GO:0006954;GO:0006955;GO:0042307;GO:0042306;GO:1902531;GO:1900180;GO:1900182;GO:0046907;GO:0080134;GO:0031401;GO:0001775;GO:0030155;GO:0030154;GO:0015833;GO:1902533;GO:0061061;GO:1904951;GO:0007259;GO:0032270;GO:0032502;GO:0032501;GO:0009987;GO:0044744;GO:0032879;GO:0016482;GO:0051251;GO:0071407;GO:0050670;GO:0050671;GO:0001816;GO:0001817;GO:0001819;GO:0034504;GO:0071222;GO:0032602;GO:0032604;GO:0042110;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0046427;GO:0046425;GO:0034613;GO:0006913;GO:0051174;GO:0009058;GO:0051170;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:1902582;GO:1902580;GO:0080090;GO:0046635;GO:0046634;GO:0046633;GO:0046631;GO:0042231;GO:0010604;GO:0070727;GO:0009617;GO:0009611;GO:0018193;GO:0042993;GO:1904591;GO:0051704;GO:0060255;GO:0046649;GO:0046640;GO:0046641;GO:0032645;GO:1903651;GO:0032649;GO:0032943;GO:0032946;GO:0032944;GO:0032496;GO:0065007;GO:1903829;GO:0034109;GO:0071593;GO:0051132;GO:0051133;GO:0051135;GO:0036211;GO:0008150;GO:0008152;GO:0016310;GO:0023056;GO:0023052;GO:0023051;GO:0010647;GO:0010646;GO:0042886;GO:0022610;GO:0032740;GO:0017038;GO:0045596;GO:0045595;GO:0051093;GO:0032268;GO:0007249;GO:1904892;GO:1904894;GO:0031325;GO:0031323;GO:0042516;GO:0042517;GO:0010467;GO:0010468;GO:0034103;GO:0034105;GO:0044267;GO:0042104;GO:0042107;GO:0042102;GO:0007159;GO:0007155;GO:0007154;GO:0044260;GO:0002250;GO:0015031;GO:0001932;GO:0001934; regulation of intracellular protein transport;nuclear transport;regulation of transport;chemokine biosynthetic process;positive regulation of intracellular transport;cellular response to stimulus;response to external biotic stimulus;MAPK cascade;protein localization;regulation of phosphorylation;positive regulation of phosphorylation;T-helper 1 type immune response;cytokine biosynthetic process;response to external stimulus;protein metabolic process;regulation of protein import;muscle cell differentiation;positive regulation of metabolic process;lymphocyte proliferation;positive regulation of protein transport;regulation of protein transport;regulation of biological process;intracellular protein transport;positive regulation of immune system process;regulation of immune system process;regulation of establishment of protein localization;single organism cell adhesion;regulation of cytoplasmic transport;cell-cell adhesion;macromolecule modification;cellular developmental process;interferon-gamma production;peptidyl-tyrosine modification;regulation of cellular protein localization;response to organic cyclic compound;positive regulation of cell proliferation;cell proliferation;positive regulation of T cell activation;regulation of cellular localization;peptidyl-tyrosine phosphorylation;regulation of cell-cell adhesion;myoblast differentiation;multicellular organism development;positive regulation of cell-cell adhesion;response to lipid;leukocyte proliferation;regulation of leukocyte proliferation;positive regulation of leukocyte proliferation;STAT cascade;protein phosphorylation;positive regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;chemokine metabolic process;natural killer cell activation;regulation of tyrosine phosphorylation of STAT protein;cellular response to oxygen-containing compound;tyrosine phosphorylation of Stat3 protein;anatomical structure development;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;interleukin-2 production;interleukin-17 production;positive regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;tissue remodeling;positive regulation of defense response;signal transduction;cell surface receptor signaling pathway;regulation of defense response;single-organism metabolic process;positive regulation of inflammatory response;positive regulation of cell adhesion;regulation of inflammatory response;regulation of myoblast differentiation;negative regulation of myoblast differentiation;macromolecule localization;positive regulation of transport;response to biotic stimulus;response to other organism;response to organic substance;regulation of transcription factor import into nucleus;transcription factor import into nucleus;protein complex localization;lipopolysaccharide-mediated signaling pathway;regulation of protein targeting;leukocyte activation;positive regulation of gene expression;type 2 immune response;anatomical structure morphogenesis;interferon-gamma biosynthetic process;interleukin-2 biosynthetic process;blood vessel development;T cell proliferation;activated T cell proliferation;regulation of natural killer cell activation;positive regulation of natural killer cell activation;regulation of natural killer cell proliferation;regulation of developmental process;positive regulation of natural killer cell proliferation;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;response to stimulus;regulation of leukocyte activation;positive regulation of nucleocytoplasmic transport;positive regulation of leukocyte activation;regulation of nucleocytoplasmic transport;positive regulation of phosphorus metabolic process;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;cellular response to chemical stimulus;single-organism process;regulation of protein localization;regulation of lymphocyte activation;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of leukocyte cell-cell adhesion;NK T cell proliferation;regulation of protein modification process;regulation of response to wounding;natural killer cell proliferation;positive regulation of response to wounding;regulation of leukocyte cell-cell adhesion;response to oxygen-containing compound;single-organism nuclear import;establishment of protein localization to organelle;cellular response to lipid;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;response to molecule of bacterial origin;protein localization to organelle;system development;regulation of interleukin-17 production;single organismal cell-cell adhesion;regulation of cell activation;positive regulation of cell activation;regulation of T cell activation;regulation of NK T cell proliferation;positive regulation of NK T cell proliferation;regulation of muscle cell differentiation;negative regulation of muscle cell differentiation;angiogenesis;intracellular signal transduction;positive regulation of phosphate metabolic process;interleukin-13 production;T cell aggregation;sleep;cell-cell signaling;response to chemical;leukocyte aggregation;tyrosine phosphorylation of STAT protein;primary metabolic process;positive regulation of NF-kappaB import into nucleus;regulation of NF-kappaB import into nucleus;NF-kappaB import into nucleus;cellular metabolic process;granulocyte macrophage colony-stimulating factor biosynthetic process;regulation of peptide transport;regulation of phosphate metabolic process;regulation of metabolic process;regulation of intracellular transport;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;regulation of signal transduction;positive regulation of signal transduction;positive regulation of tyrosine phosphorylation of STAT protein;blood vessel morphogenesis;positive regulation of interferon-gamma production;positive regulation of biological process;negative regulation of biological process;positive regulation of granulocyte macrophage colony-stimulating factor production;regulation of I-kappaB kinase/NF-kappaB signaling;positive regulation of I-kappaB kinase/NF-kappaB signaling;regulation of cell proliferation;protein import into nucleus;regulation of T cell proliferation;protein targeting;establishment of protein localization;single organism signaling;single-multicellular organism process;positive regulation of peptidyl-tyrosine phosphorylation;regulation of peptidyl-tyrosine phosphorylation;immune system process;regulation of activated T cell proliferation;macromolecule metabolic process;signal transduction by protein phosphorylation;cellular response to molecule of bacterial origin;cellular response to biotic stimulus;anatomical structure formation involved in morphogenesis;transport;defense response;response to stress;inflammatory response;immune response;positive regulation of protein import into nucleus;regulation of protein import into nucleus;regulation of intracellular signal transduction;regulation of protein localization to nucleus;positive regulation of protein localization to nucleus;intracellular transport;regulation of response to stress;positive regulation of protein modification process;cell activation;regulation of cell adhesion;cell differentiation;peptide transport;positive regulation of intracellular signal transduction;muscle structure development;positive regulation of establishment of protein localization;JAK-STAT cascade;positive regulation of cellular protein metabolic process;developmental process;multicellular organismal process;cellular process;protein targeting to nucleus;regulation of localization;cytosolic transport;positive regulation of lymphocyte activation;cellular response to organic cyclic compound;regulation of lymphocyte proliferation;positive regulation of lymphocyte proliferation;cytokine production;regulation of cytokine production;positive regulation of cytokine production;protein localization to nucleus;cellular response to lipopolysaccharide;chemokine production;granulocyte macrophage colony-stimulating factor production;T cell activation;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;positive regulation of JAK-STAT cascade;regulation of JAK-STAT cascade;cellular protein localization;nucleocytoplasmic transport;regulation of phosphorus metabolic process;biosynthetic process;nuclear import;establishment of localization in cell;localization;single-organism localization;cellular localization;single-organism intracellular transport;single-organism cellular localization;regulation of primary metabolic process;positive regulation of alpha-beta T cell activation;regulation of alpha-beta T cell activation;alpha-beta T cell proliferation;alpha-beta T cell activation;interleukin-13 biosynthetic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to bacterium;response to wounding;peptidyl-amino acid modification;positive regulation of transcription factor import into nucleus;positive regulation of protein import;multi-organism process;regulation of macromolecule metabolic process;lymphocyte activation;regulation of alpha-beta T cell proliferation;positive regulation of alpha-beta T cell proliferation;regulation of granulocyte macrophage colony-stimulating factor production;positive regulation of cytoplasmic transport;regulation of interferon-gamma production;mononuclear cell proliferation;positive regulation of mononuclear cell proliferation;regulation of mononuclear cell proliferation;response to lipopolysaccharide;biological regulation;positive regulation of cellular protein localization;homotypic cell-cell adhesion;lymphocyte aggregation;NK T cell activation;regulation of NK T cell activation;positive regulation of NK T cell activation;protein modification process;biological_process;metabolic process;phosphorylation;positive regulation of signaling;signaling;regulation of signaling;positive regulation of cell communication;regulation of cell communication;amide transport;biological adhesion;positive regulation of interleukin-17 production;protein import;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of developmental process;regulation of cellular protein metabolic process;I-kappaB kinase/NF-kappaB signaling;regulation of STAT cascade;positive regulation of STAT cascade;positive regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of tyrosine phosphorylation of Stat3 protein;positive regulation of tyrosine phosphorylation of Stat3 protein;gene expression;regulation of gene expression;regulation of tissue remodeling;positive regulation of tissue remodeling;cellular protein metabolic process;positive regulation of activated T cell proliferation;cytokine metabolic process;positive regulation of T cell proliferation;leukocyte cell-cell adhesion;cell adhesion;cell communication;cellular macromolecule metabolic process;adaptive immune response;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 6;6;4;6;4;3;4;5;4;7;7;6;5;3;4;6;5;3;5;4;5;2;6;3;3;5;3;6;4;5;4;5;8;5;5;4;3;6;4;8;5;6;4;5;5;4;5;5;6;7;4;6;3;4;3;6;5;8;5;9;3;5;4;3;3;5;5;6;6;4;4;4;5;5;3;5;4;5;6;6;3;3;3;3;4;7;6;5;6;7;3;5;4;3;6;4;4;6;7;6;6;7;3;7;3;3;3;2;4;6;4;7;5;4;4;5;4;2;4;5;3;5;5;6;8;6;5;6;4;6;4;6;5;6;5;5;6;4;5;4;4;4;6;9;9;5;5;4;5;6;5;4;4;4;3;6;8;3;7;6;6;3;4;5;6;3;5;3;3;5;5;4;4;8;4;5;2;2;5;6;6;4;5;7;6;4;3;3;8;8;2;8;4;4;5;4;3;4;4;3;5;3;5;6;5;6;4;5;4;6;4;4;5;6;5;4;3;7;5;2;2;2;5;3;6;5;6;6;6;4;4;4;7;6;5;5;5;5;3;5;5;7;7;5;7;5;3;8;4;2;3;3;5;4;4;7;7;7;6;4;4;4;4;4;7;6;5;2;4;4;8;8;5;5;5;5;6;6;5;2;3;5;7;7;8;8;5;1;2;6;3;2;3;4;4;5;2;5;5;4;4;3;5;6;6;6;4;4;9;9;5;5;4;4;5;8;5;7;5;3;4;4;4;5;7;7; GO:0044421;GO:0044464;GO:0005615;GO:0070062;GO:0043230;GO:0005829;GO:0044424;GO:0043227;GO:0043226;GO:0031982;GO:0044444;GO:0005737;GO:0005623;GO:0005622;GO:1903561;GO:0005575;GO:0005576; extracellular region part;cell part;extracellular space;extracellular exosome;extracellular organelle;cytosol;intracellular part;membrane-bounded organelle;organelle;vesicle;cytoplasmic part;cytoplasm;cell;intracellular;extracellular vesicle;cellular_component;extracellular region; 2;2;3;4;3;5;3;3;2;4;4;4;2;3;3;1;2; GO:0005488;GO:0005515;GO:0005102;GO:0003674;GO:0005125; binding;protein binding;receptor binding;molecular_function;cytokine activity; 2;3;4;1;5; K05482 map04060;map04621;map04623;map05132;map05134;map05143;map05144;map05152;map05164;map05321;map05323; Cytokine-cytokine receptor interaction;NOD-like receptor signaling pathway;Cytosolic DNA-sensing pathway;Salmonella infection;Legionellosis;African trypanosomiasis;Malaria;Tuberculosis;Influenza A;Inflammatory bowel disease (IBD);Rheumatoid arthritis; IPR008996;IPR015529;IPR000975; Cytokine IL1/FGF;Interleukin-18;Interleukin-1 family; cytosol Q6PCB0 von Willebrand factor A domain-containing protein 1 OS=Homo sapiens OX=9606 GN=VWA1 PE=1 SV=1 - [VWA1_HUMAN] 0.9 0.861 1.705 0.84 0.744 0.884 1.045296167 nan 1.129032258 nan 1.980255517 nan 1.188172043 nan GO:0007610;GO:0044699;GO:0048265;GO:0048266;GO:0016043;GO:0030198;GO:0071840;GO:0043062;GO:0032501;GO:0009987;GO:0006950;GO:0044763;GO:0044707;GO:0044708;GO:0050896;GO:0033555;GO:0008150; behavior;single-organism process;response to pain;behavioral response to pain;cellular component organization;extracellular matrix organization;cellular component organization or biogenesis;extracellular structure organization;multicellular organismal process;cellular process;response to stress;single-organism cellular process;single-multicellular organism process;single-organism behavior;response to stimulus;multicellular organismal response to stress;biological_process; 2;2;5;4;3;5;2;4;2;2;3;3;3;3;2;4;1; GO:0031012;GO:0043227;GO:0043226;GO:0005614;GO:0070062;GO:0005615;GO:1903561;GO:0031982;GO:0005604;GO:0043230;GO:0005578;GO:0005575;GO:0005576;GO:0044420;GO:0044421; extracellular matrix;membrane-bounded organelle;organelle;interstitial matrix;extracellular exosome;extracellular space;extracellular vesicle;vesicle;basement membrane;extracellular organelle;proteinaceous extracellular matrix;cellular_component;extracellular region;extracellular matrix component;extracellular region part; 2;3;2;4;4;3;3;4;3;3;3;1;2;2;2; IPR003961;IPR013783;IPR002035; Fibronectin type III;Immunoglobulin-like fold;von Willebrand factor, type A; extracellular Hs12383080 459.0 W [W] Extracellular structures; P55145 Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3 - [MANF_HUMAN] 1.067 1.01 0.836 1.11 0.963 1.893 1.056435644 nan 1.152647975 nan 0.827722772 nan 1.965732087 nan GO:0006986;GO:0006950;GO:0008150;GO:0042221;GO:0010033;GO:0050896;GO:0035966; response to unfolded protein;response to stress;biological_process;response to chemical;response to organic substance;response to stimulus;response to topologically incorrect protein; 5;3;1;3;4;2;4; GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0005576;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;nucleus;extracellular region;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;intracellular part; 3;3;2;5;2;4;2;2;3;1;3; GO:0003674;GO:0005488;GO:0003676;GO:1901363;GO:0044822;GO:0097159;GO:0003723; molecular_function;binding;nucleic acid binding;heterocyclic compound binding;poly(A) RNA binding;organic cyclic compound binding;RNA binding; 1;2;4;3;6;3;5; K22556 IPR003034;IPR019345; SAP domain;Armet protein; extracellular Hs5174393 366.0 R [R] General function prediction only; O76050 E3 ubiquitin-protein ligase NEURL1 OS=Homo sapiens OX=9606 GN=NEURL1 PE=2 SV=1 - [NEUL1_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0019220;GO:0080090;GO:0019222;GO:0007595;GO:0048585;GO:0048584;GO:0048583;GO:0016358;GO:0060491;GO:0060322;GO:0007166;GO:0007167;GO:0007169;GO:0018193;GO:0031344;GO:0071840;GO:0031346;GO:0043200;GO:0051716;GO:0007219;GO:0009968;GO:0071704;GO:0009966;GO:0048869;GO:0007519;GO:0071310;GO:0051491;GO:0010033;GO:0045664;GO:0048513;GO:0048515;GO:0010720;GO:0016310;GO:0048518;GO:0048519;GO:0060996;GO:0042127;GO:0030154;GO:0006793;GO:0060255;GO:0048468;GO:0045859;GO:0044703;GO:0007281;GO:0007176;GO:0042221;GO:0007173;GO:0010975;GO:0007288;GO:0050804;GO:0051704;GO:0042325;GO:0044700;GO:0042327;GO:0044702;GO:0040011;GO:0044707;GO:0023057;GO:0019538;GO:0050730;GO:0010243;GO:0048870;GO:0050731;GO:0098916;GO:0046847;GO:0007165;GO:0022412;GO:2000273;GO:0022607;GO:0009893;GO:0033674;GO:0006928;GO:0032941;GO:0031175;GO:1901186;GO:1901184;GO:0021700;GO:0050789;GO:0023056;GO:0044267;GO:0009653;GO:0051347;GO:0045937;GO:0016567;GO:0035082;GO:0043549;GO:0016043;GO:0009719;GO:0065007;GO:0061097;GO:0061098;GO:0065009;GO:0065008;GO:0030879;GO:0048646;GO:0051130;GO:0043085;GO:0050790;GO:0038127;GO:0060271;GO:0050767;GO:0050793;GO:0006810;GO:0007517;GO:0050794;GO:0012501;GO:0043412;GO:0036211;GO:0008150;GO:0060074;GO:0051239;GO:0051234;GO:0010604;GO:0051174;GO:0046903;GO:0044782;GO:0007420;GO:0001578;GO:0050896;GO:0031401;GO:0048170;GO:0051338;GO:0070647;GO:0051962;GO:0051960;GO:0009967;GO:0007286;GO:0010562;GO:0099536;GO:0099537;GO:0010927;GO:0050808;GO:0008152;GO:0050803;GO:0018212;GO:0008593;GO:0050807;GO:0019953;GO:0051128;GO:0090128;GO:0090129;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0061061;GO:0010647;GO:0010646;GO:0000003;GO:0044699;GO:0007417;GO:0050769;GO:0051247;GO:0032446;GO:0051240;GO:0051246;GO:0060998;GO:0060284;GO:0045746;GO:0048169;GO:0045666;GO:0045742;GO:0031399;GO:0032270;GO:0032502;GO:0008285;GO:0006996;GO:0032501;GO:0044093;GO:0050878;GO:0044238;GO:0030317;GO:0009987;GO:0045597;GO:0045595;GO:0007017;GO:1901701;GO:0001101;GO:0048232;GO:0007010;GO:0071229;GO:0048858;GO:0032268;GO:0050773;GO:0051094;GO:0048167;GO:0043170;GO:0051674;GO:0048731;GO:0048732;GO:0045860;GO:1901698;GO:0071495;GO:1901699;GO:0030030;GO:0030031;GO:0031325;GO:0031323;GO:0018108;GO:0042058;GO:0060999;GO:0014706;GO:0044237;GO:0042384;GO:0010942;GO:0008219;GO:0010941;GO:0007275;GO:0007276;GO:0048609;GO:0000226;GO:0009888;GO:0032504;GO:1900006;GO:0006513;GO:0042981;GO:0071417;GO:0008283;GO:1902589;GO:0043065;GO:0043067;GO:0010469;GO:0043068;GO:0048666;GO:0045741;GO:0006468;GO:0071230;GO:0030182;GO:0007589;GO:0048168;GO:0006915;GO:0006464;GO:0044767;GO:0022414;GO:0044765;GO:0032990;GO:0044763;GO:0007268;GO:0007267;GO:0007154;GO:0022008;GO:0070925;GO:0051179;GO:1902578;GO:0000902;GO:1901700;GO:0051489;GO:0048699;GO:0001932;GO:0044260;GO:0007399;GO:0003006;GO:0048856;GO:0007283;GO:0010976;GO:0044087;GO:0006796;GO:0044085;GO:2000026;GO:0032989;GO:0060537;GO:0060538;GO:0044089;GO:0001934;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;lactation;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;dendrite development;regulation of cell projection assembly;head development;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;peptidyl-amino acid modification;regulation of cell projection organization;cellular component organization or biogenesis;positive regulation of cell projection organization;response to amino acid;cellular response to stimulus;Notch signaling pathway;negative regulation of signal transduction;organic substance metabolic process;regulation of signal transduction;cellular developmental process;skeletal muscle tissue development;cellular response to organic substance;positive regulation of filopodium assembly;response to organic substance;regulation of neuron differentiation;animal organ development;spermatid differentiation;positive regulation of cell development;phosphorylation;positive regulation of biological process;negative regulation of biological process;dendritic spine development;regulation of cell proliferation;cell differentiation;phosphorus metabolic process;regulation of macromolecule metabolic process;cell development;regulation of protein kinase activity;multi-organism reproductive process;germ cell development;regulation of epidermal growth factor-activated receptor activity;response to chemical;epidermal growth factor receptor signaling pathway;regulation of neuron projection development;sperm axoneme assembly;modulation of synaptic transmission;multi-organism process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;single organism reproductive process;locomotion;single-multicellular organism process;negative regulation of signaling;protein metabolic process;regulation of peptidyl-tyrosine phosphorylation;response to organonitrogen compound;cell motility;positive regulation of peptidyl-tyrosine phosphorylation;anterograde trans-synaptic signaling;filopodium assembly;signal transduction;cellular process involved in reproduction in multicellular organism;positive regulation of receptor activity;cellular component assembly;positive regulation of metabolic process;positive regulation of kinase activity;movement of cell or subcellular component;secretion by tissue;neuron projection development;positive regulation of ERBB signaling pathway;regulation of ERBB signaling pathway;developmental maturation;regulation of biological process;positive regulation of signaling;cellular protein metabolic process;anatomical structure morphogenesis;positive regulation of transferase activity;positive regulation of phosphate metabolic process;protein ubiquitination;axoneme assembly;regulation of kinase activity;cellular component organization;response to endogenous stimulus;biological regulation;regulation of protein tyrosine kinase activity;positive regulation of protein tyrosine kinase activity;regulation of molecular function;regulation of biological quality;mammary gland development;anatomical structure formation involved in morphogenesis;positive regulation of cellular component organization;positive regulation of catalytic activity;regulation of catalytic activity;ERBB signaling pathway;cilium morphogenesis;regulation of neurogenesis;regulation of developmental process;transport;muscle organ development;regulation of cellular process;programmed cell death;macromolecule modification;protein modification process;biological_process;synapse maturation;regulation of multicellular organismal process;establishment of localization;positive regulation of macromolecule metabolic process;regulation of phosphorus metabolic process;secretion;cilium organization;brain development;microtubule bundle formation;response to stimulus;positive regulation of protein modification process;positive regulation of long-term neuronal synaptic plasticity;regulation of transferase activity;protein modification by small protein conjugation or removal;positive regulation of nervous system development;regulation of nervous system development;positive regulation of signal transduction;spermatid development;positive regulation of phosphorus metabolic process;synaptic signaling;trans-synaptic signaling;cellular component assembly involved in morphogenesis;synapse organization;metabolic process;regulation of synapse structure or activity;peptidyl-tyrosine modification;regulation of Notch signaling pathway;regulation of synapse organization;sexual reproduction;regulation of cellular component organization;regulation of synapse maturation;positive regulation of synapse maturation;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;muscle structure development;positive regulation of cell communication;regulation of cell communication;reproduction;single-organism process;central nervous system development;positive regulation of neurogenesis;positive regulation of protein metabolic process;protein modification by small protein conjugation;positive regulation of multicellular organismal process;regulation of protein metabolic process;regulation of dendritic spine development;regulation of cell development;negative regulation of Notch signaling pathway;regulation of long-term neuronal synaptic plasticity;positive regulation of neuron differentiation;positive regulation of epidermal growth factor receptor signaling pathway;regulation of protein modification process;positive regulation of cellular protein metabolic process;developmental process;negative regulation of cell proliferation;organelle organization;multicellular organismal process;positive regulation of molecular function;regulation of body fluid levels;primary metabolic process;sperm motility;cellular process;positive regulation of cell differentiation;regulation of cell differentiation;microtubule-based process;cellular response to oxygen-containing compound;response to acid chemical;male gamete generation;cytoskeleton organization;cellular response to acid chemical;cell projection morphogenesis;regulation of cellular protein metabolic process;regulation of dendrite development;positive regulation of developmental process;regulation of synaptic plasticity;macromolecule metabolic process;localization of cell;system development;gland development;positive regulation of protein kinase activity;response to nitrogen compound;cellular response to endogenous stimulus;cellular response to nitrogen compound;cell projection organization;cell projection assembly;positive regulation of cellular metabolic process;regulation of cellular metabolic process;peptidyl-tyrosine phosphorylation;regulation of epidermal growth factor receptor signaling pathway;positive regulation of dendritic spine development;striated muscle tissue development;cellular metabolic process;cilium assembly;positive regulation of cell death;cell death;regulation of cell death;multicellular organism development;gamete generation;multicellular organismal reproductive process;microtubule cytoskeleton organization;tissue development;multicellular organism reproduction;positive regulation of dendrite development;protein monoubiquitination;regulation of apoptotic process;cellular response to organonitrogen compound;cell proliferation;single-organism organelle organization;positive regulation of apoptotic process;regulation of programmed cell death;regulation of receptor activity;positive regulation of programmed cell death;neuron development;positive regulation of epidermal growth factor-activated receptor activity;protein phosphorylation;cellular response to amino acid stimulus;neuron differentiation;body fluid secretion;regulation of neuronal synaptic plasticity;apoptotic process;cellular protein modification process;single-organism developmental process;reproductive process;single-organism transport;cell part morphogenesis;single-organism cellular process;synaptic transmission;cell-cell signaling;cell communication;neurogenesis;organelle assembly;localization;single-organism localization;cell morphogenesis;response to oxygen-containing compound;regulation of filopodium assembly;generation of neurons;regulation of protein phosphorylation;cellular macromolecule metabolic process;nervous system development;developmental process involved in reproduction;anatomical structure development;spermatogenesis;positive regulation of neuron projection development;regulation of cellular component biogenesis;phosphate-containing compound metabolic process;cellular component biogenesis;regulation of multicellular organismal development;cellular component morphogenesis;muscle tissue development;skeletal muscle organ development;positive regulation of cellular component biogenesis;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;5;3;3;3;4;4;4;5;6;7;7;5;2;5;5;3;6;4;3;4;4;7;5;4;4;7;4;4;5;6;2;2;4;4;5;4;4;4;7;3;4;5;3;9;6;4;4;2;7;3;7;3;2;3;3;4;8;4;3;8;7;6;4;4;5;4;3;7;4;4;5;5;5;4;2;3;5;3;6;6;9;5;6;3;3;2;8;9;3;3;5;3;4;5;4;8;6;6;3;4;5;3;5;5;5;1;5;3;3;4;5;5;5;4;6;2;6;6;5;7;4;5;4;5;5;5;6;4;4;2;4;8;5;5;3;4;6;5;2;4;4;3;4;4;4;2;2;5;5;5;8;3;5;5;5;5;7;6;6;6;5;2;4;4;2;4;4;3;4;2;4;4;4;5;4;5;5;5;5;5;5;3;5;4;3;4;4;8;4;4;5;4;5;4;4;8;6;5;6;3;5;4;4;4;4;4;3;5;4;3;5;10;6;5;3;4;6;5;4;5;5;6;7;6;6;5;6;6;6;3;2;4;5;3;8;4;4;6;5;2;3;5;4;5;7;7;4;5;3;3;6;6;3;5;3;4;4;5;6;3;7;3;3; GO:0030425;GO:0097060;GO:0043204;GO:0016020;GO:0044297;GO:0036477;GO:0048471;GO:0044424;GO:0044425;GO:0042995;GO:0043232;GO:0043229;GO:0005622;GO:0030054;GO:0043025;GO:0005737;GO:0060076;GO:0097440;GO:0044444;GO:0098590;GO:0099572;GO:0043005;GO:0044459;GO:0045211;GO:0043197;GO:0044463;GO:0044464;GO:0005623;GO:0045202;GO:0071944;GO:0044309;GO:0098805;GO:0097458;GO:0098794;GO:0044456;GO:0098589;GO:0005886;GO:0043228;GO:0005575;GO:0043226;GO:0014069; dendrite;synaptic membrane;perikaryon;membrane;cell body;somatodendritic compartment;perinuclear region of cytoplasm;intracellular part;membrane part;cell projection;intracellular non-membrane-bounded organelle;intracellular organelle;intracellular;cell junction;neuronal cell body;cytoplasm;excitatory synapse;apical dendrite;cytoplasmic part;plasma membrane region;postsynaptic specialization;neuron projection;plasma membrane part;postsynaptic membrane;dendritic spine;cell projection part;cell part;cell;synapse;cell periphery;neuron spine;whole membrane;neuron part;postsynapse;synapse part;membrane region;plasma membrane;non-membrane-bounded organelle;cellular_component;organelle;postsynaptic density; 5;3;4;2;3;4;5;3;2;3;4;3;3;2;4;4;3;6;4;4;3;4;3;4;4;3;2;2;2;3;5;3;3;3;2;3;3;3;1;2;4; GO:0008270;GO:0016740;GO:0046872;GO:0045183;GO:0003674;GO:0005488;GO:0046914;GO:0004842;GO:0003824;GO:0019787;GO:0043169;GO:0016874;GO:0043167;GO:0061659;GO:0061630;GO:0045182; zinc ion binding;transferase activity;metal ion binding;translation factor activity, non-nucleic acid binding;molecular_function;binding;transition metal ion binding;ubiquitin-protein transferase activity;catalytic activity;ubiquitin-like protein transferase activity;cation binding;ligase activity;ion binding;ubiquitin-like protein ligase activity;ubiquitin protein ligase activity;translation regulator activity; 7;3;5;3;1;2;6;5;2;4;4;3;3;5;6;2; K01931 IPR001841;IPR006573; Zinc finger, RING-type;Neuralized homology repeat (NHR) domain; nucleus Hs21314781_1 1028.0 T [T] Signal transduction mechanisms; Q12888 TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2 - [TP53B_HUMAN] 1.138 1.333 0.475 1.442 1.118 0.591 0.853713428 nan 1.28980322 nan 0.356339085 nan 0.52862254 nan GO:0009628;GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0044710;GO:0006303;GO:0006302;GO:0070647;GO:0018193;GO:0032446;GO:0044093;GO:0048518;GO:0006281;GO:0060255;GO:0006366;GO:2001141;GO:0046483;GO:0019538;GO:0018205;GO:0033554;GO:0019438;GO:0009893;GO:0009891;GO:0006807;GO:0097659;GO:0044267;GO:0044260;GO:0065007;GO:0007049;GO:0065009;GO:0071214;GO:0018130;GO:0010165;GO:0009889;GO:0051716;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0034654;GO:0010604;GO:0016070;GO:0044271;GO:0050896;GO:0006950;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0032774;GO:0071481;GO:0009314;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0071479;GO:0071478;GO:0010212;GO:0000726;GO:0000725;GO:0000724;GO:1903508;GO:0044238;GO:0043687;GO:0009987;GO:0006725;GO:1903506;GO:0045893;GO:0000077;GO:0016925;GO:0051091;GO:0051090;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0045944;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0022402;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:1901576;GO:0019219;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0006310;GO:0006974;GO:0031570;GO:0000075;GO:0044237;GO:0006259;GO:0048522; response to abiotic stimulus;regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;single-organism metabolic process;double-strand break repair via nonhomologous end joining;double-strand break repair;protein modification by small protein conjugation or removal;peptidyl-amino acid modification;protein modification by small protein conjugation;positive regulation of molecular function;positive regulation of biological process;DNA repair;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;regulation of RNA biosynthetic process;heterocycle metabolic process;protein metabolic process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;positive regulation of metabolic process;positive regulation of biosynthetic process;nitrogen compound metabolic process;nucleic acid-templated transcription;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;cell cycle;regulation of molecular function;cellular response to abiotic stimulus;heterocycle biosynthetic process;response to X-ray;regulation of biosynthetic process;cellular response to stimulus;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;positive regulation of macromolecule metabolic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;response to stress;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;RNA biosynthetic process;cellular response to X-ray;response to radiation;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;cellular response to ionizing radiation;cellular response to radiation;response to ionizing radiation;non-recombinational repair;recombinational repair;double-strand break repair via homologous recombination;positive regulation of nucleic acid-templated transcription;primary metabolic process;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;positive regulation of transcription, DNA-templated;DNA damage checkpoint;protein sumoylation;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of sequence-specific DNA binding transcription factor activity;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cell cycle process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;DNA recombination;cellular response to DNA damage stimulus;DNA integrity checkpoint;cell cycle checkpoint;cellular metabolic process;DNA metabolic process;positive regulation of cellular process; 3;4;3;5;4;3;6;5;7;7;8;4;2;4;4;7;6;4;4;8;4;5;3;4;3;7;5;4;2;4;3;4;5;6;4;3;3;5;5;1;2;5;4;5;5;2;3;6;5;5;6;6;7;4;4;4;5;2;4;6;5;5;5;5;6;7;3;7;2;4;7;6;6;9;5;4;5;5;4;6;5;7;5;5;4;4;5;4;6;2;3;5;7;5;5;4;5;6;3;5;3;4;4;6;5;6;5;3;5;3; GO:0031974;GO:0043228;GO:0031981;GO:0000793;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044427;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0098687;GO:0044446;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0005694;GO:0000779;GO:0000775;GO:0000776;GO:0000777;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;non-membrane-bounded organelle;nuclear lumen;condensed chromosome;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;chromosomal part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;chromosomal region;intracellular organelle part;cytoplasm;nucleus;cell part;cell;chromosome;condensed chromosome, centromeric region;chromosome, centromeric region;kinetochore;condensed chromosome kinetochore;macromolecular complex;cellular_component;intracellular organelle lumen; 2;3;5;6;3;4;4;3;4;3;4;2;3;3;3;2;5;5;3;4;5;2;2;5;7;6;4;5;2;1;4; GO:0035064;GO:0001076;GO:1901363;GO:0003712;GO:0008134;GO:0042393;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0000988;GO:0097159;GO:0033613;GO:0001085;GO:0001104;GO:0001102;GO:0005515;GO:0002039; methylated histone binding;transcription factor activity, RNA polymerase II transcription factor binding;heterocyclic compound binding;transcription cofactor activity;transcription factor binding;histone binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;organic cyclic compound binding;activating transcription factor binding;RNA polymerase II transcription factor binding;RNA polymerase II transcription cofactor activity;RNA polymerase II activating transcription factor binding;protein binding;p53 binding; 5;4;3;4;4;4;1;2;4;5;3;2;3;5;5;5;6;3;4; K20915 IPR014722;IPR001357;IPR015125; Ribosomal protein L2 domain 2;BRCT domain;Tumour suppressor p53-binding protein-1 Tudor domain; nucleus Hs5032189 4017.0 L [L] Replication, recombination and repair; Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=4 - [ITIH4_HUMAN] 1.019 0.923 1.082 1.055 0.931 1.156 1.104008667 2.84E-11 1.133190118 2.35E-40 1.172264355 7.68E-49 1.241675618 8.00E-38 GO:0006954;GO:0030203;GO:0019222;GO:0050896;GO:0031323;GO:0045861;GO:1903510;GO:0050789;GO:0006807;GO:0044237;GO:0002526;GO:0009892;GO:0043170;GO:0080090;GO:0044267;GO:0051248;GO:0010605;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0010033;GO:0030212;GO:0031324;GO:0034097;GO:0052547;GO:0052548;GO:0050794;GO:0006952;GO:0006022;GO:0006950;GO:0008150;GO:0008152;GO:0010951;GO:0051346;GO:0006508;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:1901564;GO:0050790;GO:0006953;GO:0060255;GO:1901135;GO:0019538;GO:0042221;GO:0030162;GO:0009987;GO:0048523; inflammatory response;glycosaminoglycan metabolic process;regulation of metabolic process;response to stimulus;regulation of cellular metabolic process;negative regulation of proteolysis;mucopolysaccharide metabolic process;regulation of biological process;nitrogen compound metabolic process;cellular metabolic process;acute inflammatory response;negative regulation of metabolic process;macromolecule metabolic process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;response to organic substance;hyaluronan metabolic process;negative regulation of cellular metabolic process;response to cytokine;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular process;defense response;aminoglycan metabolic process;response to stress;biological_process;metabolic process;negative regulation of endopeptidase activity;negative regulation of hydrolase activity;proteolysis;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;organonitrogen compound metabolic process;regulation of catalytic activity;acute-phase response;regulation of macromolecule metabolic process;carbohydrate derivative metabolic process;protein metabolic process;response to chemical;regulation of proteolysis;cellular process;negative regulation of cellular process; 5;6;3;2;4;6;7;2;3;3;6;3;4;4;5;5;4;4;5;5;3;7;2;4;2;3;4;8;4;5;6;7;3;4;5;3;1;2;8;6;5;5;3;5;5;4;4;7;4;4;4;3;6;2;3; GO:0005886;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0005615;GO:0016020;GO:0072562;GO:0071944;GO:0043230;GO:1903561;GO:0031982;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421; plasma membrane;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;extracellular space;membrane;blood microparticle;cell periphery;extracellular organelle;extracellular vesicle;vesicle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part; 3;3;2;4;4;3;2;3;3;3;3;4;2;2;3;1;2;3;2; GO:0004866;GO:0030414;GO:0003674;GO:0004857;GO:0098772;GO:0061135;GO:0030234;GO:0061134;GO:0004867; endopeptidase inhibitor activity;peptidase inhibitor activity;molecular_function;enzyme inhibitor activity;molecular function regulator;endopeptidase regulator activity;enzyme regulator activity;peptidase regulator activity;serine-type endopeptidase inhibitor activity; 6;5;1;4;2;5;3;4;7; IPR013694;IPR002035;IPR010600; VIT domain;von Willebrand factor, type A;Inter-alpha-trypsin inhibitor heavy chain, C-terminal; extracellular 320160484 203.0 R [R] General function prediction only; COG2304 Secreted protein containing bacterial Ig-like domain and vWFA domain O95460 Matrilin-4 OS=Homo sapiens OX=9606 GN=MATN4 PE=1 SV=3 - [MATN4_HUMAN] 1.114 1.036 0.814 1.239 0.988 1.273 1.075289575 nan 1.254048583 nan 0.785714286 nan 1.288461538 nan GO:0043062;GO:0009987;GO:0016043;GO:0044763;GO:0044699;GO:0030198;GO:0008150;GO:0071840; extracellular structure organization;cellular process;cellular component organization;single-organism cellular process;single-organism process;extracellular matrix organization;biological_process;cellular component organization or biogenesis; 4;2;3;3;2;5;1;2; GO:0005575;GO:0005576; cellular_component;extracellular region; 1;2; IPR019466;IPR034306;IPR000152;IPR002035;IPR009030;IPR000742;IPR026823;IPR001881;IPR013032; Matrilin, coiled-coil trimerisation domain;Matrilin-4;EGF-type aspartate/asparagine hydroxylation site;von Willebrand factor, type A;Growth factor receptor cysteine-rich domain;EGF-like domain;Complement Clr-like EGF domain;EGF-like calcium-binding domain;EGF-like, conserved site; extracellular Hs13699830 1163.0 T [T] Signal transduction mechanisms; Q96ST3 Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2 - [SIN3A_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0007599;GO:0007596;GO:0044281;GO:0051716;GO:0043207;GO:0016458;GO:0060548;GO:0046483;GO:0009607;GO:0009605;GO:0034284;GO:0019538;GO:0010638;GO:0010639;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0050778;GO:0071867;GO:0071868;GO:0071869;GO:0050789;GO:0002684;GO:0002682;GO:0071840;GO:1903308;GO:1903309;GO:0018130;GO:0007623;GO:0006629;GO:0043412;GO:0002520;GO:0016070;GO:0010557;GO:0010556;GO:2001252;GO:0010558;GO:2001251;GO:0034504;GO:0051129;GO:0051128;GO:1903827;GO:1901990;GO:1901992;GO:0014070;GO:1903828;GO:0000122;GO:0035601;GO:0050878;GO:0098542;GO:0044255;GO:0006979;GO:1903351;GO:1903350;GO:0060341;GO:0042592;GO:0042593;GO:0022402;GO:0008219;GO:0007275;GO:2000112;GO:2000113;GO:0043067;GO:0043066;GO:0045814;GO:0043069;GO:0045089;GO:0000278;GO:0019219;GO:0045087;GO:0006464;GO:0044767;GO:0044763;GO:0010389;GO:1901700;GO:1901701;GO:0051276;GO:0048856;GO:2000756;GO:2000757;GO:0048523;GO:0048522;GO:0008104;GO:0000086;GO:0031349;GO:0031347;GO:0044710;GO:0045787;GO:0032101;GO:0071310;GO:0071331;GO:0071333;GO:0033036;GO:0043966;GO:2001141;GO:0051707;GO:0010033;GO:0051704;GO:0018205;GO:1901674;GO:1901675;GO:0016568;GO:0016569;GO:0002831;GO:0010629;GO:0006807;GO:0045088;GO:0044267;GO:0044260;GO:0044699;GO:0006366;GO:0006915;GO:0009889;GO:0050794;GO:0044092;GO:0071870;GO:0050896;GO:0002697;GO:1903310;GO:0033044;GO:0033043;GO:0010564;GO:0070887;GO:0007049;GO:0032880;GO:0051248;GO:0051246;GO:0051179;GO:0043392;GO:0031399;GO:1902680;GO:0002230;GO:0033365;GO:0048731;GO:0043933;GO:0006325;GO:0042981;GO:1902589;GO:0045931;GO:0045935;GO:0045934;GO:0090068;GO:0010817;GO:0042221;GO:0043620;GO:0006996;GO:0044238;GO:0009743;GO:0044237;GO:0009749;GO:0006259;GO:0019222;GO:0006473;GO:0048584;GO:0006475;GO:0006476;GO:0031057;GO:0031056;GO:1901362;GO:1901360;GO:0035065;GO:0048869;GO:0040029;GO:0048511;GO:0048513;GO:0048518;GO:0048519;GO:0042752;GO:0042754;GO:0044707;GO:0071322;GO:0010243;GO:0071326;GO:0002376;GO:0033554;GO:0043974;GO:0051101;GO:0051100;GO:0043170;GO:0097659;GO:0043543;GO:0016575;GO:0016570;GO:0016573;GO:0018393;GO:0018394;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0001678;GO:0006955;GO:0034654;GO:1900181;GO:1900180;GO:0044271;GO:0051607;GO:0031400;GO:0043900;GO:0006355;GO:0006357;GO:0006351;GO:0031937;GO:0031935;GO:0032774;GO:0030154;GO:0009611;GO:0006139;GO:0001701;GO:0043618;GO:0043619;GO:0043009;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0032879;GO:0090304;GO:0050776;GO:0071407;GO:0051253;GO:0051252;GO:0051254;GO:2000677;GO:0080134;GO:2000678;GO:1902275;GO:0044839;GO:0050688;GO:0071704;GO:0002244;GO:1902751;GO:0034613;GO:1902679;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0051173;GO:0034599;GO:0051641;GO:0051726;GO:1901654;GO:0080090;GO:0035067;GO:0010605;GO:0010604;GO:0070727;GO:0009615;GO:0018193;GO:0006260;GO:0019725;GO:0060255;GO:0010971;GO:0071242;GO:0051595;GO:0048878;GO:0019438;GO:0098732;GO:1901576;GO:0007346;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:0051130;GO:0009719;GO:0042060;GO:1901987;GO:1901984;GO:0036211;GO:0008150;GO:1901983;GO:0008152;GO:0050691;GO:1901989;GO:1901698;GO:1901699;GO:0002218;GO:0009790;GO:0034641;GO:0009792;GO:0034645;GO:0006342;GO:0060968;GO:0009746;GO:0060359;GO:0048583;GO:0045892;GO:0045893;GO:0055082;GO:0032269;GO:0032268;GO:0007568;GO:0051098;GO:0010628;GO:0045944;GO:0030097;GO:0071495;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:1903047;GO:0044770;GO:0044772;GO:0010941;GO:0071417;GO:0033500;GO:1903508;GO:0010467;GO:0048534;GO:0010468;GO:1902749;GO:0002253;GO:0002252;GO:0044249; hemostasis;blood coagulation;small molecule metabolic process;cellular response to stimulus;response to external biotic stimulus;gene silencing;negative regulation of cell death;heterocycle metabolic process;response to biotic stimulus;response to external stimulus;response to monosaccharide;protein metabolic process;positive regulation of organelle organization;negative regulation of organelle organization;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of immune response;response to monoamine;cellular response to monoamine stimulus;response to catecholamine;regulation of biological process;positive regulation of immune system process;regulation of immune system process;cellular component organization or biogenesis;regulation of chromatin modification;negative regulation of chromatin modification;heterocycle biosynthetic process;circadian rhythm;lipid metabolic process;macromolecule modification;immune system development;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;positive regulation of chromosome organization;negative regulation of macromolecule biosynthetic process;negative regulation of chromosome organization;protein localization to nucleus;negative regulation of cellular component organization;regulation of cellular component organization;regulation of cellular protein localization;regulation of mitotic cell cycle phase transition;positive regulation of mitotic cell cycle phase transition;response to organic cyclic compound;negative regulation of cellular protein localization;negative regulation of transcription from RNA polymerase II promoter;protein deacylation;regulation of body fluid levels;defense response to other organism;cellular lipid metabolic process;response to oxidative stress;cellular response to dopamine;response to dopamine;regulation of cellular localization;homeostatic process;glucose homeostasis;cell cycle process;cell death;multicellular organism development;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of gene expression, epigenetic;negative regulation of programmed cell death;positive regulation of innate immune response;mitotic cell cycle;regulation of nucleobase-containing compound metabolic process;innate immune response;cellular protein modification process;single-organism developmental process;single-organism cellular process;regulation of G2/M transition of mitotic cell cycle;response to oxygen-containing compound;cellular response to oxygen-containing compound;chromosome organization;anatomical structure development;regulation of peptidyl-lysine acetylation;negative regulation of peptidyl-lysine acetylation;negative regulation of cellular process;positive regulation of cellular process;protein localization;G2/M transition of mitotic cell cycle;positive regulation of defense response;regulation of defense response;single-organism metabolic process;positive regulation of cell cycle;regulation of response to external stimulus;cellular response to organic substance;cellular response to hexose stimulus;cellular response to glucose stimulus;macromolecule localization;histone H3 acetylation;regulation of RNA biosynthetic process;response to other organism;response to organic substance;multi-organism process;peptidyl-lysine modification;regulation of histone H3-K27 acetylation;negative regulation of histone H3-K27 acetylation;chromatin modification;covalent chromatin modification;regulation of response to biotic stimulus;negative regulation of gene expression;nitrogen compound metabolic process;regulation of innate immune response;cellular protein metabolic process;cellular macromolecule metabolic process;single-organism process;transcription from RNA polymerase II promoter;apoptotic process;regulation of biosynthetic process;regulation of cellular process;negative regulation of molecular function;cellular response to catecholamine stimulus;response to stimulus;regulation of immune effector process;positive regulation of chromatin modification;regulation of chromosome organization;regulation of organelle organization;regulation of cell cycle process;cellular response to chemical stimulus;cell cycle;regulation of protein localization;negative regulation of protein metabolic process;regulation of protein metabolic process;localization;negative regulation of DNA binding;regulation of protein modification process;positive regulation of RNA biosynthetic process;positive regulation of defense response to virus by host;protein localization to organelle;system development;macromolecular complex subunit organization;chromatin organization;regulation of apoptotic process;single-organism organelle organization;positive regulation of mitotic cell cycle;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;positive regulation of cell cycle process;regulation of hormone levels;response to chemical;regulation of DNA-templated transcription in response to stress;organelle organization;primary metabolic process;response to carbohydrate;cellular metabolic process;response to glucose;DNA metabolic process;regulation of metabolic process;protein acetylation;positive regulation of response to stimulus;internal protein amino acid acetylation;protein deacetylation;negative regulation of histone modification;regulation of histone modification;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of histone acetylation;cellular developmental process;regulation of gene expression, epigenetic;rhythmic process;animal organ development;positive regulation of biological process;negative regulation of biological process;regulation of circadian rhythm;negative regulation of circadian rhythm;single-multicellular organism process;cellular response to carbohydrate stimulus;response to organonitrogen compound;cellular response to monosaccharide stimulus;immune system process;cellular response to stress;histone H3-K27 acetylation;regulation of DNA binding;negative regulation of binding;macromolecule metabolic process;nucleic acid-templated transcription;protein acylation;histone deacetylation;histone modification;histone acetylation;internal peptidyl-lysine acetylation;peptidyl-lysine acetylation;defense response;programmed cell death;response to stress;coagulation;cellular glucose homeostasis;immune response;nucleobase-containing compound biosynthetic process;negative regulation of protein localization to nucleus;regulation of protein localization to nucleus;cellular nitrogen compound biosynthetic process;defense response to virus;negative regulation of protein modification process;regulation of multi-organism process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;positive regulation of chromatin silencing;regulation of chromatin silencing;RNA biosynthetic process;cell differentiation;response to wounding;nucleobase-containing compound metabolic process;in utero embryonic development;regulation of transcription from RNA polymerase II promoter in response to stress;regulation of transcription from RNA polymerase II promoter in response to oxidative stress;chordate embryonic development;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;regulation of localization;nucleic acid metabolic process;regulation of immune response;cellular response to organic cyclic compound;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;regulation of transcription regulatory region DNA binding;regulation of response to stress;negative regulation of transcription regulatory region DNA binding;regulation of chromatin organization;cell cycle G2/M phase transition;regulation of defense response to virus;organic substance metabolic process;hematopoietic progenitor cell differentiation;positive regulation of cell cycle G2/M phase transition;cellular protein localization;negative regulation of RNA biosynthetic process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cellular response to oxidative stress;cellular localization;regulation of cell cycle;response to ketone;regulation of primary metabolic process;negative regulation of histone acetylation;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;response to virus;peptidyl-amino acid modification;DNA replication;cellular homeostasis;regulation of macromolecule metabolic process;positive regulation of G2/M transition of mitotic cell cycle;cellular response to ammonium ion;response to methylglyoxal;chemical homeostasis;aromatic compound biosynthetic process;macromolecule deacylation;organic substance biosynthetic process;regulation of mitotic cell cycle;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;response to endogenous stimulus;wound healing;regulation of cell cycle phase transition;negative regulation of protein acetylation;protein modification process;biological_process;regulation of protein acetylation;metabolic process;regulation of defense response to virus by host;positive regulation of cell cycle phase transition;response to nitrogen compound;cellular response to nitrogen compound;activation of innate immune response;embryo development;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;cellular macromolecule biosynthetic process;chromatin silencing;regulation of gene silencing;response to hexose;response to ammonium ion;regulation of response to stimulus;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;cellular chemical homeostasis;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;aging;regulation of binding;positive regulation of gene expression;positive regulation of transcription from RNA polymerase II promoter;hemopoiesis;cellular response to endogenous stimulus;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;cell cycle phase transition;mitotic cell cycle phase transition;regulation of cell death;cellular response to organonitrogen compound;carbohydrate homeostasis;positive regulation of nucleic acid-templated transcription;gene expression;hematopoietic or lymphoid organ development;regulation of gene expression;regulation of cell cycle G2/M phase transition;activation of immune response;immune effector process;cellular biosynthetic process; 5;5;4;3;4;4;4;4;3;3;6;4;5;5;3;3;4;4;4;5;6;5;2;3;3;2;7;7;5;3;4;5;3;5;5;5;6;5;6;7;4;4;5;6;6;5;3;7;7;4;4;4;4;7;6;4;4;7;4;4;4;6;6;5;6;6;5;5;5;5;4;6;3;3;7;4;5;5;3;8;8;3;3;4;6;4;5;3;4;4;5;8;7;3;6;6;3;4;2;8;7;7;6;7;4;5;3;5;5;4;2;7;6;4;3;4;6;2;4;7;6;5;5;4;4;4;5;5;2;6;6;6;6;6;4;4;5;6;4;5;5;5;5;4;3;5;4;3;5;3;8;5;3;8;3;9;8;5;5;5;4;6;4;6;2;4;2;2;3;3;3;6;4;7;2;4;7;5;5;4;7;7;5;4;5;10;9;4;5;3;4;6;3;5;4;6;5;4;6;3;6;7;6;6;5;6;5;4;4;8;6;6;7;2;2;2;4;7;7;3;5;4;6;5;5;5;6;4;7;6;6;4;3;6;7;5;6;3;5;4;4;4;5;3;4;5;4;6;4;4;4;4;7;6;4;4;7;6;6;5;5;6;4;5;3;2;3;3;4;3;5;6;7;5;1;7;2;5;6;4;5;4;5;4;6;5;5;4;7;5;3;6;6;5;5;5;4;4;5;7;5;4;5;5;5;4;4;4;5;5;6;4;5;6;7;5;4;5;7;3;3;4; GO:0044428;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0005654;GO:0045171;GO:0044464;GO:0070013;GO:1902494;GO:0000790;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0000118;GO:0000785;GO:0017053;GO:0031974;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0044446;GO:0005737;GO:0005730;GO:0005634;GO:0070822;GO:0000775;GO:0000776;GO:0031981;GO:0005667;GO:0000228;GO:0098687;GO:0044454;GO:0044451;GO:0032991;GO:0005623;GO:0005622;GO:0005694;GO:0016580;GO:0005575;GO:0005576; nuclear part;intracellular part;chromosomal part;extracellular region part;organelle part;nucleoplasm;intercellular bridge;cell part;intracellular organelle lumen;catalytic complex;nuclear chromatin;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;histone deacetylase complex;chromatin;transcriptional repressor complex;membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;intracellular organelle part;cytoplasm;nucleolus;nucleus;Sin3-type complex;chromosome, centromeric region;kinetochore;nuclear lumen;transcription factor complex;nuclear chromosome;chromosomal region;nuclear chromosome part;nucleoplasm part;macromolecular complex;cell;intracellular;chromosome;Sin3 complex;cellular_component;extracellular region; 4;3;4;2;2;5;3;2;4;4;4;3;4;4;3;5;3;4;2;3;3;3;2;3;4;5;5;5;6;4;5;4;5;5;5;5;2;2;3;5;6;1;2; GO:0001067;GO:0044212;GO:0005488;GO:0016787;GO:0000976;GO:0000975;GO:0033613;GO:0043565;GO:0019213;GO:0001085;GO:0008134;GO:0005515;GO:0003700;GO:1901363;GO:0033558;GO:0003674;GO:0003676;GO:0003677;GO:0003824;GO:0097159;GO:0001076;GO:0001071;GO:0003714;GO:0003712;GO:0044877;GO:0000989;GO:0000988;GO:1990837;GO:0001104;GO:0001106;GO:0001102;GO:0003690;GO:0003723;GO:0003682;GO:0001191; regulatory region nucleic acid binding;transcription regulatory region DNA binding;binding;hydrolase activity;transcription regulatory region sequence-specific DNA binding;regulatory region DNA binding;activating transcription factor binding;sequence-specific DNA binding;deacetylase activity;RNA polymerase II transcription factor binding;transcription factor binding;protein binding;transcription factor activity, sequence-specific DNA binding;heterocyclic compound binding;protein deacetylase activity;molecular_function;nucleic acid binding;DNA binding;catalytic activity;organic cyclic compound binding;transcription factor activity, RNA polymerase II transcription factor binding;nucleic acid binding transcription factor activity;transcription corepressor activity;transcription cofactor activity;macromolecular complex binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;sequence-specific double-stranded DNA binding;RNA polymerase II transcription cofactor activity;RNA polymerase II transcription corepressor activity;RNA polymerase II activating transcription factor binding;double-stranded DNA binding;RNA binding;chromatin binding;transcriptional repressor activity, RNA polymerase II transcription factor binding; 5;7;2;3;8;6;5;6;4;5;4;3;3;3;5;1;4;5;2;3;4;2;5;4;3;3;2;7;5;6;6;6;5;4;5; K11644 map04139;map04919;map05016;map05202; Regulation of mitophagy - yeast;Thyroid hormone signaling pathway;Huntington's disease;Transcriptional misregulation in cancer; IPR031693;IPR003822;IPR013194; Sin3, C-terminal;Paired amphipathic helix;Histone deacetylase interacting domain; nucleus Hs22056376 2657.0 B [B] Chromatin structure and dynamics; P07954 Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3 - [FUMH_HUMAN] 0.919 1.033 0.869 1.272 0.573 3.141 0.88964182 nan 2.219895288 nan 0.841239109 nan 5.481675393 nan GO:0022607;GO:0060249;GO:0043933;GO:0044237;GO:0019752;GO:0042592;GO:0016043;GO:0043648;GO:0006091;GO:0072350;GO:0044699;GO:0044710;GO:0009060;GO:0071822;GO:0070271;GO:0051262;GO:0065003;GO:0071704;GO:0044085;GO:0065007;GO:0071840;GO:0015980;GO:0006106;GO:0065008;GO:0032501;GO:0044238;GO:0006082;GO:0009987;GO:0008150;GO:0008152;GO:0043436;GO:0001894;GO:0055114;GO:0048872;GO:0051259;GO:0006461;GO:0048873;GO:0048871;GO:0044707;GO:0006099;GO:0044763;GO:0006101;GO:0045333;GO:0006108;GO:0044281; cellular component assembly;anatomical structure homeostasis;macromolecular complex subunit organization;cellular metabolic process;carboxylic acid metabolic process;homeostatic process;cellular component organization;dicarboxylic acid metabolic process;generation of precursor metabolites and energy;tricarboxylic acid metabolic process;single-organism process;single-organism metabolic process;aerobic respiration;protein complex subunit organization;protein complex biogenesis;protein tetramerization;macromolecular complex assembly;organic substance metabolic process;cellular component biogenesis;biological regulation;cellular component organization or biogenesis;energy derivation by oxidation of organic compounds;fumarate metabolic process;regulation of biological quality;multicellular organismal process;primary metabolic process;organic acid metabolic process;cellular process;biological_process;metabolic process;oxoacid metabolic process;tissue homeostasis;oxidation-reduction process;homeostasis of number of cells;protein oligomerization;protein complex assembly;homeostasis of number of cells within a tissue;multicellular organismal homeostasis;single-multicellular organism process;tricarboxylic acid cycle;single-organism cellular process;citrate metabolic process;cellular respiration;malate metabolic process;small molecule metabolic process; 4;5;4;3;6;4;3;7;4;7;2;3;6;5;4;7;5;3;3;2;2;4;8;3;2;3;4;2;1;2;5;5;4;5;6;5;6;4;3;4;3;8;5;8;4; GO:0043231;GO:0043229;GO:0005739;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070062;GO:0070013;GO:0032991;GO:0043234;GO:0031982;GO:0005759;GO:0031974;GO:0045239;GO:0043230;GO:1903561;GO:0043233;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044429;GO:0044424;GO:0044421;GO:0044422; intracellular membrane-bounded organelle;intracellular organelle;mitochondrion;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;extracellular exosome;intracellular organelle lumen;macromolecular complex;protein complex;vesicle;mitochondrial matrix;membrane-enclosed lumen;tricarboxylic acid cycle enzyme complex;extracellular organelle;extracellular vesicle;organelle lumen;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;mitochondrial part;intracellular part;extracellular region part;organelle part; 4;3;5;3;2;4;3;4;4;2;3;4;5;2;4;3;3;3;5;2;2;3;1;4;2;4;3;2;2; GO:0016836;GO:0003674;GO:0016829;GO:0003824;GO:0016835;GO:0004333; hydro-lyase activity;molecular_function;lyase activity;catalytic activity;carbon-oxygen lyase activity;fumarate hydratase activity; 5;1;3;2;4;6; K01679 map00020;map00620;map00720;map01100;map01110;map01120;map01130;map01200;map05200;map05211; Citrate cycle (TCA cycle);Pyruvate metabolism;Carbon fixation pathways in prokaryotes;Metabolic pathways;Biosynthesis of secondary metabolites;Microbial metabolism in diverse environments;Biosynthesis of antibiotics;Carbon metabolism;Pathways in cancer;Renal cell carcinoma; IPR018951;IPR020557;IPR008948;IPR022761;IPR024083;IPR000362;IPR005677; Fumarase C, C-terminal;Fumarate lyase, conserved site;L-Aspartase-like;Fumarate lyase, N-terminal;Fumarase/histidase, N-terminal;Fumarate lyase family;Fumarate hydratase, class II; mitochondria Hs19743875 1051.0 C [C] Energy production and conversion; Q02985 Complement factor H-related protein 3 OS=Homo sapiens OX=9606 GN=CFHR3 PE=1 SV=2 - [FHR3_HUMAN] 0.786 0.719 1.593 0.822 0.816 2.065 1.093184979 nan 1.007352941 nan 2.215577191 nan 2.530637255 nan GO:0043230;GO:0070062;GO:0005615;GO:0072562;GO:0044421;GO:0005575;GO:0005576;GO:1903561;GO:0043227;GO:0043226;GO:0031982; extracellular organelle;extracellular exosome;extracellular space;blood microparticle;extracellular region part;cellular_component;extracellular region;extracellular vesicle;membrane-bounded organelle;organelle;vesicle; 3;4;3;3;2;1;2;3;3;2;4; IPR000436; Sushi/SCR/CCP domain; extracellular Q14774 H2.0-like homeobox protein OS=Homo sapiens OX=9606 GN=HLX PE=1 SV=3 - [HLX_HUMAN] 1.043 1.214 0.86 0.91 1.322 0.509 0.859143328 nan 0.688350983 nan 0.708401977 nan 0.385022693 nan GO:0080090;GO:0034111;GO:0034110;GO:0046637;GO:0046636;GO:0048585;GO:0046634;GO:0048583;GO:0046632;GO:0046631;GO:0007162;GO:0035265;GO:0045629;GO:1901362;GO:1901360;GO:0034112;GO:0007517;GO:0046639;GO:0045785;GO:0048869;GO:0002263;GO:0007519;GO:0048513;GO:0048518;GO:0048519;GO:0046635;GO:0042127;GO:0045063;GO:0048584;GO:0002828;GO:0002829;GO:0060255;GO:0002827;GO:0002824;GO:0002825;GO:0002822;GO:0002821;GO:1903708;GO:0046649;GO:2001141;GO:0046620;GO:1903706;GO:1903707;GO:0046483;GO:0045580;GO:0042088;GO:0044707;GO:0045581;GO:0051094;GO:0045582;GO:0002376;GO:0019438;GO:2000516;GO:0048562;GO:0048565;GO:0048566;GO:0048568;GO:0050778;GO:0008152;GO:0045321;GO:0098602;GO:0048589;GO:0043170;GO:0050789;GO:0097659;GO:0042093;GO:0042092;GO:0002286;GO:0002287;GO:0044260;GO:0002285;GO:0050793;GO:0002684;GO:0002366;GO:0065007;GO:0002683;GO:0071593;GO:0018130;GO:0009887;GO:0048557;GO:0006139;GO:0098609;GO:0051240;GO:0009889;GO:0009888;GO:0050794;GO:0001775;GO:0008150;GO:0051239;GO:0006955;GO:0034654;GO:0002521;GO:0002520;GO:0016070;GO:0002293;GO:0002292;GO:0044271;GO:0002294;GO:0050896;GO:0019222;GO:0002695;GO:0002694;GO:0002697;GO:0010556;GO:0043370;GO:0070489;GO:0002699;GO:0002698;GO:0035710;GO:0051171;GO:0048639;GO:0048638;GO:0032774;GO:0030155;GO:0030154;GO:0002819;GO:0055123;GO:0009790;GO:0034641;GO:0034645;GO:0061061;GO:0009653;GO:0044699;GO:0045927;GO:0051249;GO:1903039;GO:0051241;GO:1903038;GO:0045628;GO:0045621;GO:0045620;GO:0045623;GO:0045622;GO:0045625;GO:0043367;GO:0045627;GO:1903037;GO:0008284;GO:0032501;GO:0035239;GO:0008283;GO:0046638;GO:0009987;GO:0006725;GO:2000514;GO:2000515;GO:0045597;GO:0045596;GO:0045595;GO:0042110;GO:0051093;GO:0050777;GO:0050776;GO:0002460;GO:0045064;GO:0051251;GO:0051250;GO:0051252;GO:0048484;GO:0006807;GO:0050870;GO:0045619;GO:0030098;GO:0043371;GO:0048731;GO:0048732;GO:0043372;GO:0048546;GO:0048483;GO:0032502;GO:0016337;GO:0050868;GO:0050865;GO:0031326;GO:0050867;GO:0050866;GO:0031323;GO:0050863;GO:0090304;GO:0022407;GO:0014706;GO:0001889;GO:0007275;GO:0022408;GO:0022409;GO:1902107;GO:0002682;GO:0040007;GO:0006355;GO:0040008;GO:0030217;GO:2000112;GO:0071704;GO:0010467;GO:0002696;GO:0045624;GO:0048534;GO:0010468;GO:0006351;GO:0048598;GO:1901576;GO:0019219;GO:0034109;GO:0046622;GO:0002252;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:1903506;GO:0007155;GO:0061008;GO:0035295;GO:0070486;GO:0007159;GO:0044238;GO:0007399;GO:0022610;GO:0048856;GO:0044237;GO:0030097;GO:1902106;GO:1902105;GO:2000026;GO:0002250;GO:0060537;GO:0060538;GO:0044249;GO:0048523;GO:0048522; regulation of primary metabolic process;negative regulation of homotypic cell-cell adhesion;regulation of homotypic cell-cell adhesion;regulation of alpha-beta T cell differentiation;negative regulation of alpha-beta T cell activation;negative regulation of response to stimulus;regulation of alpha-beta T cell activation;regulation of response to stimulus;alpha-beta T cell differentiation;alpha-beta T cell activation;negative regulation of cell adhesion;organ growth;negative regulation of T-helper 2 cell differentiation;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;positive regulation of homotypic cell-cell adhesion;muscle organ development;negative regulation of alpha-beta T cell differentiation;positive regulation of cell adhesion;cellular developmental process;cell activation involved in immune response;skeletal muscle tissue development;animal organ development;positive regulation of biological process;negative regulation of biological process;positive regulation of alpha-beta T cell activation;regulation of cell proliferation;T-helper 1 cell differentiation;positive regulation of response to stimulus;regulation of type 2 immune response;negative regulation of type 2 immune response;regulation of macromolecule metabolic process;positive regulation of T-helper 1 type immune response;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of T-helper 1 type immune response;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of adaptive immune response;positive regulation of hemopoiesis;lymphocyte activation;regulation of RNA biosynthetic process;regulation of organ growth;regulation of hemopoiesis;negative regulation of hemopoiesis;heterocycle metabolic process;regulation of T cell differentiation;T-helper 1 type immune response;single-multicellular organism process;negative regulation of T cell differentiation;positive regulation of developmental process;positive regulation of T cell differentiation;immune system process;aromatic compound biosynthetic process;positive regulation of CD4-positive, alpha-beta T cell activation;embryonic organ morphogenesis;digestive tract development;embryonic digestive tract development;embryonic organ development;positive regulation of immune response;metabolic process;leukocyte activation;single organism cell adhesion;developmental growth;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;T-helper cell differentiation;type 2 immune response;T cell activation involved in immune response;alpha-beta T cell activation involved in immune response;cellular macromolecule metabolic process;lymphocyte activation involved in immune response;regulation of developmental process;positive regulation of immune system process;leukocyte activation involved in immune response;biological regulation;negative regulation of immune system process;lymphocyte aggregation;heterocycle biosynthetic process;organ morphogenesis;embryonic digestive tract morphogenesis;nucleobase-containing compound metabolic process;cell-cell adhesion;positive regulation of multicellular organismal process;regulation of biosynthetic process;tissue development;regulation of cellular process;cell activation;biological_process;regulation of multicellular organismal process;immune response;nucleobase-containing compound biosynthetic process;leukocyte differentiation;immune system development;RNA metabolic process;alpha-beta T cell differentiation involved in immune response;T cell differentiation involved in immune response;cellular nitrogen compound biosynthetic process;CD4-positive, alpha-beta T cell differentiation involved in immune response;response to stimulus;regulation of metabolic process;negative regulation of leukocyte activation;regulation of leukocyte activation;regulation of immune effector process;regulation of macromolecule biosynthetic process;regulation of CD4-positive, alpha-beta T cell differentiation;T cell aggregation;positive regulation of immune effector process;negative regulation of immune effector process;CD4-positive, alpha-beta T cell activation;regulation of nitrogen compound metabolic process;positive regulation of developmental growth;regulation of developmental growth;RNA biosynthetic process;regulation of cell adhesion;cell differentiation;regulation of adaptive immune response;digestive system development;embryo development;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;muscle structure development;anatomical structure morphogenesis;single-organism process;positive regulation of growth;regulation of lymphocyte activation;positive regulation of leukocyte cell-cell adhesion;negative regulation of multicellular organismal process;negative regulation of leukocyte cell-cell adhesion;regulation of T-helper 2 cell differentiation;positive regulation of lymphocyte differentiation;negative regulation of lymphocyte differentiation;negative regulation of T-helper cell differentiation;regulation of T-helper cell differentiation;regulation of T-helper 1 cell differentiation;CD4-positive, alpha-beta T cell differentiation;positive regulation of T-helper 1 cell differentiation;regulation of leukocyte cell-cell adhesion;positive regulation of cell proliferation;multicellular organismal process;tube morphogenesis;cell proliferation;positive regulation of alpha-beta T cell differentiation;cellular process;cellular aromatic compound metabolic process;regulation of CD4-positive, alpha-beta T cell activation;negative regulation of CD4-positive, alpha-beta T cell activation;positive regulation of cell differentiation;negative regulation of cell differentiation;regulation of cell differentiation;T cell activation;negative regulation of developmental process;negative regulation of immune response;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;T-helper 2 cell differentiation;positive regulation of lymphocyte activation;negative regulation of lymphocyte activation;regulation of RNA metabolic process;enteric nervous system development;nitrogen compound metabolic process;positive regulation of T cell activation;regulation of lymphocyte differentiation;lymphocyte differentiation;negative regulation of CD4-positive, alpha-beta T cell differentiation;system development;gland development;positive regulation of CD4-positive, alpha-beta T cell differentiation;digestive tract morphogenesis;autonomic nervous system development;developmental process;single organismal cell-cell adhesion;negative regulation of T cell activation;regulation of cell activation;regulation of cellular biosynthetic process;positive regulation of cell activation;negative regulation of cell activation;regulation of cellular metabolic process;regulation of T cell activation;nucleic acid metabolic process;regulation of cell-cell adhesion;striated muscle tissue development;liver development;multicellular organism development;negative regulation of cell-cell adhesion;positive regulation of cell-cell adhesion;positive regulation of leukocyte differentiation;regulation of immune system process;growth;regulation of transcription, DNA-templated;regulation of growth;T cell differentiation;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;positive regulation of leukocyte activation;positive regulation of T-helper cell differentiation;hematopoietic or lymphoid organ development;regulation of gene expression;transcription, DNA-templated;embryonic morphogenesis;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;homotypic cell-cell adhesion;positive regulation of organ growth;immune effector process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nucleic acid-templated transcription;cell adhesion;hepaticobiliary system development;tube development;leukocyte aggregation;leukocyte cell-cell adhesion;primary metabolic process;nervous system development;biological adhesion;anatomical structure development;cellular metabolic process;hemopoiesis;negative regulation of leukocyte differentiation;regulation of leukocyte differentiation;regulation of multicellular organismal development;adaptive immune response;muscle tissue development;skeletal muscle organ development;cellular biosynthetic process;negative regulation of cellular process;positive regulation of cellular process; 4;6;6;8;7;3;7;3;7;6;4;4;6;5;4;6;5;8;4;4;4;7;4;2;2;7;4;6;3;5;5;4;7;6;7;6;5;4;4;6;4;4;4;4;7;6;3;7;3;7;2;5;8;5;4;5;4;4;2;3;3;3;4;2;7;5;4;4;4;4;4;3;3;4;2;3;7;5;4;6;4;4;3;4;4;3;4;1;3;3;5;6;3;5;4;4;5;4;2;3;4;4;4;5;9;4;4;4;7;4;4;4;6;4;5;5;5;5;4;5;4;3;2;3;5;6;3;6;6;6;6;5;5;6;8;6;6;4;2;4;3;8;2;4;8;8;4;4;4;5;3;4;4;5;5;5;5;5;5;3;6;6;5;9;4;4;9;5;5;2;4;6;4;5;4;4;4;6;5;5;6;5;4;5;5;5;3;2;6;3;6;6;3;5;4;5;4;5;6;4;4;5;5;4;3;3;3;5;3;7;3;5;4;6;5;3;5;2;3;3;5;5;5;4;4;5;6;4;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0097159;GO:0043565; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;organic cyclic compound binding;sequence-specific DNA binding; 3;1;2;4;5;3;6; K09339 IPR020479;IPR000047;IPR017970;IPR001356;IPR009057; Homeobox domain, metazoa;Helix-turn-helix motif;Homeobox, conserved site;Homeobox domain;Homeobox domain-like; nucleus Hs11386181 979.0 R [R] General function prediction only; P07225 Vitamin K-dependent protein S OS=Homo sapiens OX=9606 GN=PROS1 PE=1 SV=1 - [PROS_HUMAN] 0.982 0.926 1.07 1.026 0.956 1.213 1.060475162 0.006011868 1.073221757 2.39E-06 1.155507559 6.17E-10 1.268828452 3.70E-06 GO:0007599;GO:0080090;GO:0019222;GO:0051049;GO:0048585;GO:0048584;GO:0048583;GO:0006909;GO:0031347;GO:0044710;GO:0043207;GO:0018214;GO:0050727;GO:0018193;GO:0044092;GO:0048518;GO:0065007;GO:0007596;GO:0010605;GO:0051050;GO:0060255;GO:2000257;GO:0032268;GO:0030162;GO:0002673;GO:1901564;GO:0051128;GO:0051707;GO:0010033;GO:0030168;GO:0051704;GO:0016477;GO:0009607;GO:0044707;GO:0048870;GO:0019538;GO:0017187;GO:0018200;GO:0061041;GO:0002376;GO:0030449;GO:0006928;GO:0002920;GO:0032496;GO:0050789;GO:0009605;GO:0044267;GO:0006888;GO:0051346;GO:0044260;GO:0006887;GO:0016043;GO:0045055;GO:0002684;GO:1900047;GO:0002682;GO:0071840;GO:0065009;GO:0065008;GO:0051130;GO:0050766;GO:0052547;GO:0006810;GO:0051248;GO:0042060;GO:0050794;GO:0006952;GO:0030193;GO:0006950;GO:0050817;GO:0006956;GO:0006954;GO:0006955;GO:0002526;GO:0006959;GO:0050818;GO:0050819;GO:0051336;GO:0046903;GO:0070613;GO:0006897;GO:0051604;GO:0050896;GO:0043412;GO:0036211;GO:0030195;GO:0008150;GO:1903317;GO:0009617;GO:0032102;GO:0008152;GO:0032101;GO:0001775;GO:0009611;GO:0034641;GO:0009892;GO:0043086;GO:0044699;GO:0050764;GO:0051234;GO:0051241;GO:0051246;GO:0006508;GO:1903034;GO:1903035;GO:1901700;GO:0032501;GO:0050878;GO:0043687;GO:0009987;GO:0042730;GO:0060627;GO:0048519;GO:0016485;GO:0032879;GO:0032269;GO:0050776;GO:0046907;GO:0043603;GO:0050778;GO:0043170;GO:0051239;GO:0051674;GO:0002237;GO:0045861;GO:0080134;GO:1900046;GO:0031324;GO:0031323;GO:0006807;GO:0050900;GO:0061045;GO:0072376;GO:0033993;GO:0002576;GO:0032940;GO:0002697;GO:0071704;GO:0010467;GO:0010466;GO:0010468;GO:0048193;GO:0052548;GO:0045087;GO:0006464;GO:0006465;GO:0044765;GO:0044763;GO:0051649;GO:0010951;GO:0042221;GO:0030100;GO:0051179;GO:1902578;GO:0051641;GO:0040011;GO:0044238;GO:0050790;GO:0006518;GO:0044237;GO:0002253;GO:0002252;GO:1902582;GO:0045807;GO:0048522;GO:0048523;GO:0016192; hemostasis;regulation of primary metabolic process;regulation of metabolic process;regulation of transport;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;phagocytosis;regulation of defense response;single-organism metabolic process;response to external biotic stimulus;protein carboxylation;regulation of inflammatory response;peptidyl-amino acid modification;negative regulation of molecular function;positive regulation of biological process;biological regulation;blood coagulation;negative regulation of macromolecule metabolic process;positive regulation of transport;regulation of macromolecule metabolic process;regulation of protein activation cascade;regulation of cellular protein metabolic process;regulation of proteolysis;regulation of acute inflammatory response;organonitrogen compound metabolic process;regulation of cellular component organization;response to other organism;response to organic substance;platelet activation;multi-organism process;cell migration;response to biotic stimulus;single-multicellular organism process;cell motility;protein metabolic process;peptidyl-glutamic acid carboxylation;peptidyl-glutamic acid modification;regulation of wound healing;immune system process;regulation of complement activation;movement of cell or subcellular component;regulation of humoral immune response;response to lipopolysaccharide;regulation of biological process;response to external stimulus;cellular protein metabolic process;ER to Golgi vesicle-mediated transport;negative regulation of hydrolase activity;cellular macromolecule metabolic process;exocytosis;cellular component organization;regulated exocytosis;positive regulation of immune system process;negative regulation of hemostasis;regulation of immune system process;cellular component organization or biogenesis;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;positive regulation of phagocytosis;regulation of peptidase activity;transport;negative regulation of protein metabolic process;wound healing;regulation of cellular process;defense response;regulation of blood coagulation;response to stress;coagulation;complement activation;inflammatory response;immune response;acute inflammatory response;humoral immune response;regulation of coagulation;negative regulation of coagulation;regulation of hydrolase activity;secretion;regulation of protein processing;endocytosis;protein maturation;response to stimulus;macromolecule modification;protein modification process;negative regulation of blood coagulation;biological_process;regulation of protein maturation;response to bacterium;negative regulation of response to external stimulus;metabolic process;regulation of response to external stimulus;cell activation;response to wounding;cellular nitrogen compound metabolic process;negative regulation of metabolic process;negative regulation of catalytic activity;single-organism process;regulation of phagocytosis;establishment of localization;negative regulation of multicellular organismal process;regulation of protein metabolic process;proteolysis;regulation of response to wounding;negative regulation of response to wounding;response to oxygen-containing compound;multicellular organismal process;regulation of body fluid levels;post-translational protein modification;cellular process;fibrinolysis;regulation of vesicle-mediated transport;negative regulation of biological process;protein processing;regulation of localization;negative regulation of cellular protein metabolic process;regulation of immune response;intracellular transport;cellular amide metabolic process;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;localization of cell;response to molecule of bacterial origin;negative regulation of proteolysis;regulation of response to stress;regulation of hemostasis;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nitrogen compound metabolic process;leukocyte migration;negative regulation of wound healing;protein activation cascade;response to lipid;platelet degranulation;secretion by cell;regulation of immune effector process;organic substance metabolic process;gene expression;negative regulation of peptidase activity;regulation of gene expression;Golgi vesicle transport;regulation of endopeptidase activity;innate immune response;cellular protein modification process;signal peptide processing;single-organism transport;single-organism cellular process;establishment of localization in cell;negative regulation of endopeptidase activity;response to chemical;regulation of endocytosis;localization;single-organism localization;cellular localization;locomotion;primary metabolic process;regulation of catalytic activity;peptide metabolic process;cellular metabolic process;activation of immune response;immune effector process;single-organism intracellular transport;positive regulation of endocytosis;positive regulation of cellular process;negative regulation of cellular process;vesicle-mediated transport; 5;4;3;4;3;3;3;5;5;3;4;7;5;7;4;2;2;5;4;3;4;4;5;6;6;4;4;3;4;5;2;4;3;3;3;4;8;8;6;2;5;4;5;5;2;3;5;7;6;4;5;3;6;3;4;3;2;3;3;4;5;6;4;5;5;3;4;5;3;4;4;5;3;6;4;4;4;5;5;7;6;5;2;5;5;5;1;6;4;4;2;4;4;4;4;3;5;2;6;3;3;5;5;5;4;4;2;4;7;2;6;4;2;6;3;5;4;5;5;4;4;3;3;5;6;4;4;4;4;3;3;5;3;5;7;4;4;3;5;7;5;6;7;4;6;6;4;3;4;8;3;5;2;3;3;2;3;4;5;3;3;3;5;4;3;3;5; GO:0031974;GO:0005789;GO:0072562;GO:0005783;GO:0031983;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0005794;GO:0099503;GO:0098588;GO:0043230;GO:0034774;GO:0043234;GO:0043231;GO:0043233;GO:0044431;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0044433;GO:0044432;GO:0030141;GO:0071944;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0097708;GO:0005886;GO:0042175;GO:0060205;GO:0005737;GO:0031091;GO:0031090;GO:0031093;GO:0031410;GO:0070062;GO:0044464;GO:0005623;GO:0005796;GO:0005615;GO:0043226;GO:1903561;GO:0032991;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;endoplasmic reticulum membrane;blood microparticle;endoplasmic reticulum;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;Golgi apparatus;secretory vesicle;bounding membrane of organelle;extracellular organelle;secretory granule lumen;protein complex;intracellular membrane-bounded organelle;organelle lumen;Golgi apparatus part;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;cytoplasmic vesicle part;endoplasmic reticulum part;secretory granule;cell periphery;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;intracellular vesicle;plasma membrane;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;organelle membrane;platelet alpha granule lumen;cytoplasmic vesicle;extracellular exosome;cell part;cell;Golgi lumen;extracellular space;organelle;extracellular vesicle;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 2;3;3;4;4;4;5;2;5;4;6;4;3;5;3;4;3;4;3;2;2;2;3;3;3;4;4;4;3;3;5;3;4;4;3;3;5;4;5;3;6;5;4;2;2;5;3;2;3;2;1;4;2; GO:0030414;GO:0098772;GO:0046872;GO:0061135;GO:0003674;GO:0005488;GO:0030234;GO:0004857;GO:0043169;GO:0043167;GO:0005509;GO:0004866;GO:0061134; peptidase inhibitor activity;molecular function regulator;metal ion binding;endopeptidase regulator activity;molecular_function;binding;enzyme regulator activity;enzyme inhibitor activity;cation binding;ion binding;calcium ion binding;endopeptidase inhibitor activity;peptidase regulator activity; 5;2;5;5;1;2;3;4;4;3;6;6;4; K03908 map04610; Complement and coagulation cascades; IPR000152;IPR018097;IPR000294;IPR009030;IPR017857;IPR013320;IPR033189;IPR000742;IPR001881;IPR013032;IPR001791; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Gamma-carboxyglutamic acid-rich (GLA) domain;Growth factor receptor cysteine-rich domain;Coagulation factor, subgroup, Gla domain;Concanavalin A-like lectin/glucanase domain;Vitamin K-dependent protein S;EGF-like domain;EGF-like calcium-binding domain;EGF-like, conserved site;Laminin G domain; extracellular E9PAV3 Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1 - [NACAM_HUMAN] 1.063 0.955 1.089 1.086 0.981 1.033 1.113089005 nan 1.107033639 nan 1.140314136 nan 1.053007136 nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0044237;GO:0034645;GO:0043170;GO:1901362;GO:0050789;GO:1901360;GO:0032774;GO:1901576;GO:0044260;GO:2000112;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0060255;GO:0051252;GO:0006355;GO:0010556;GO:0006351;GO:0019438; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of biological process;organic cyclic compound metabolic process;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of macromolecule metabolic process;regulation of RNA metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process; 4;3;5;4;5;4;4;3;3;5;4;5;2;4;6;4;4;6;3;5;2;7;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;4;5;6;5;6;5; GO:0005737;GO:0043227;GO:0005634;GO:0043226;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; cytoplasm;membrane-bounded organelle;nucleus;organelle;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 4;3;5;2;4;2;3;2;3;1;3; GO:0003674;GO:0003677;GO:0003676;GO:0097159;GO:1901363;GO:0005488; molecular_function;DNA binding;nucleic acid binding;organic cyclic compound binding;heterocyclic compound binding;binding; 1;5;4;3;3;2; K03626 IPR016641;IPR002715; Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex NAC domain; nucleus Hs14042953 358.0 K [K] Transcription; A2RRD8 Zinc finger protein 320 OS=Homo sapiens OX=9606 GN=ZNF320 PE=1 SV=1 - [ZN320_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:0031326;GO:0031323;GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0034645;GO:0043170;GO:1901360;GO:0032774;GO:1901576;GO:0044260;GO:1901362;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0065007;GO:0097659;GO:0060255;GO:0010468;GO:0018130;GO:0006139;GO:0019219;GO:0009889;GO:0009987;GO:0006725;GO:1903506;GO:0050794;GO:0009058;GO:0009059;GO:0008150;GO:0051171;GO:0008152;GO:2001141;GO:0034654;GO:0046483;GO:0016070;GO:0044238;GO:0044271;GO:0051252;GO:0006355;GO:0010556;GO:0006351;GO:0019438;GO:0044237; regulation of primary metabolic process;regulation of metabolic process;regulation of cellular biosynthetic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cellular macromolecule biosynthetic process;macromolecule metabolic process;organic cyclic compound metabolic process;RNA biosynthetic process;organic substance biosynthetic process;cellular macromolecule metabolic process;organic cyclic compound biosynthetic process;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;biological regulation;nucleic acid-templated transcription;regulation of macromolecule metabolic process;regulation of gene expression;heterocycle biosynthetic process;nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;regulation of biosynthetic process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cellular process;biosynthetic process;macromolecule biosynthetic process;biological_process;regulation of nitrogen compound metabolic process;metabolic process;regulation of RNA biosynthetic process;nucleobase-containing compound biosynthetic process;heterocycle metabolic process;RNA metabolic process;primary metabolic process;cellular nitrogen compound biosynthetic process;regulation of RNA metabolic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;aromatic compound biosynthetic process;cellular metabolic process; 4;3;5;4;5;4;4;3;5;4;4;6;4;4;5;6;2;3;5;2;7;4;5;5;4;5;4;2;4;7;3;3;5;1;4;2;6;5;4;5;3;5;5;6;5;6;5;3; GO:0043227;GO:0043226;GO:0005634;GO:0043231;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0005575;GO:0044424; membrane-bounded organelle;organelle;nucleus;intracellular membrane-bounded organelle;cell part;intracellular organelle;cell;intracellular;cellular_component;intracellular part; 3;2;5;4;2;3;2;3;1;3; GO:0043169;GO:0003674;GO:0001071;GO:0003677;GO:0046872;GO:0003676;GO:0043167;GO:0003700;GO:0097159;GO:1901363;GO:0005488; cation binding;molecular_function;nucleic acid binding transcription factor activity;DNA binding;metal ion binding;nucleic acid binding;ion binding;transcription factor activity, sequence-specific DNA binding;organic cyclic compound binding;heterocyclic compound binding;binding; 4;1;2;5;5;4;3;3;3;3;2; K09228 IPR001909;IPR013083;IPR013087; Krueppel-associated box;Zinc finger, RING/FYVE/PHD-type;Zinc finger C2H2-type; nucleus Hs22050981 1044.0 R [R] General function prediction only; P09871 Complement C1s subcomponent OS=Homo sapiens OX=9606 GN=C1S PE=1 SV=1 - [C1S_HUMAN] 0.945 1.008 1.02 1.015 1.02 1.082 0.9375 0.043133266 0.995098039 0.228038198 1.011904762 0.023028786 1.060784314 0.002594163 GO:0019724;GO:0048584;GO:0048583;GO:0044699;GO:0044710;GO:0006959;GO:0072376;GO:0050789;GO:0071704;GO:0002684;GO:0002682;GO:0048518;GO:0065007;GO:0045087;GO:0006952;GO:0006950;GO:0016064;GO:0008150;GO:0008152;GO:0006955;GO:0006958;GO:0044238;GO:0050776;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0002455;GO:0050778;GO:0002443;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0006956; B cell mediated immunity;positive regulation of response to stimulus;regulation of response to stimulus;single-organism process;single-organism metabolic process;humoral immune response;protein activation cascade;regulation of biological process;organic substance metabolic process;positive regulation of immune system process;regulation of immune system process;positive regulation of biological process;biological regulation;innate immune response;defense response;response to stress;immunoglobulin mediated immune response;biological_process;metabolic process;immune response;complement activation, classical pathway;primary metabolic process;regulation of immune response;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;humoral immune response mediated by circulating immunoglobulin;positive regulation of immune response;leukocyte mediated immunity;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;complement activation; 6;3;3;2;3;4;3;2;3;3;3;2;2;4;4;3;7;1;2;3;5;3;4;5;5;4;2;5;4;4;4;2;4;3;3;4; GO:0043227;GO:0043226;GO:0005575;GO:0070062;GO:0005615;GO:0072562;GO:0005576;GO:1903561;GO:0031982;GO:0043230;GO:0044421; membrane-bounded organelle;organelle;cellular_component;extracellular exosome;extracellular space;blood microparticle;extracellular region;extracellular vesicle;vesicle;extracellular organelle;extracellular region part; 3;2;1;4;3;3;2;3;4;3;2; GO:0004252;GO:0004175;GO:0043169;GO:0003674;GO:0005488;GO:0008233;GO:0043167;GO:0008236;GO:0005509;GO:0046872;GO:0042802;GO:0016787;GO:0005515;GO:0017171;GO:0003824;GO:0070011; serine-type endopeptidase activity;endopeptidase activity;cation binding;molecular_function;binding;peptidase activity;ion binding;serine-type peptidase activity;calcium ion binding;metal ion binding;identical protein binding;hydrolase activity;protein binding;serine hydrolase activity;catalytic activity;peptidase activity, acting on L-amino acid peptides; 6;6;4;1;2;4;3;5;6;5;4;3;3;4;2;5; K01331 map04610;map05133;map05150;map05322; Complement and coagulation cascades;Pertussis;Staphylococcus aureus infection;Systemic lupus erythematosus; IPR000152;IPR018097;IPR001254;IPR000859;IPR000436;IPR035708;IPR009003;IPR001314;IPR001881;IPR033116; EGF-type aspartate/asparagine hydroxylation site;EGF-like calcium-binding, conserved site;Serine proteases, trypsin domain;CUB domain;Sushi/SCR/CCP domain;Complement C1s subcomponent;Peptidase S1, PA clan;Peptidase S1A, chymotrypsin family;EGF-like calcium-binding domain;Serine proteases, trypsin family, serine active site; extracellular Hs4502495 1430.0 E [E] Amino acid transport and metabolism; Q9UP38 Frizzled-1 OS=Homo sapiens OX=9606 GN=FZD1 PE=1 SV=2 - [FZD1_HUMAN] 0.644 0.733 2.044 0.818 0.74 0.924 0.878581173 nan 1.105405405 nan 2.788540246 nan 1.248648649 nan GO:0033157;GO:0051169;GO:0051049;GO:0001503;GO:0003151;GO:0003150;GO:0051716;GO:0030855;GO:0048585;GO:0060541;GO:0032387;GO:0001843;GO:0046483;GO:0042325;GO:0042327;GO:0009605;GO:0030509;GO:0019538;GO:0072359;GO:0072358;GO:1904589;GO:0009892;GO:0009893;GO:0009890;GO:0009891;GO:0090263;GO:0035414;GO:0030177;GO:0035411;GO:0035412;GO:0051223;GO:0051224;GO:0050789;GO:0003205;GO:0003206;GO:0006886;GO:0071840;GO:0018130;GO:0070201;GO:1903649;GO:0009888;GO:0060606;GO:0043412;GO:0016070;GO:0010557;GO:0010556;GO:0048869;GO:0097305;GO:0010558;GO:0097306;GO:0003007;GO:1903827;GO:0051174;GO:1903828;GO:0033273;GO:0035239;GO:0060341;GO:0060022;GO:0060021;GO:0007275;GO:0033993;GO:2000112;GO:2000113;GO:0048598;GO:0090092;GO:0021915;GO:0019219;GO:0090317;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0001838;GO:1901701;GO:0003279;GO:0071542;GO:0048856;GO:0006796;GO:2000026;GO:2000027;GO:0006793;GO:0048523;GO:0048522;GO:0008104;GO:0007164;GO:0007165;GO:0007166;GO:0007167;GO:0070848;GO:0045667;GO:0044093;GO:0033036;GO:0051051;GO:2001141;GO:0010033;GO:0014020;GO:0031668;GO:0031669;GO:0090177;GO:0090175;GO:0023057;GO:0090179;GO:0090178;GO:0031667;GO:0090090;GO:1903533;GO:0003281;GO:0006468;GO:0010629;GO:0006807;GO:0033280;GO:0044267;GO:0010646;GO:0044260;GO:0006366;GO:0009887;GO:0050793;GO:0009889;GO:0035425;GO:0050794;GO:0060071;GO:0060070;GO:0051239;GO:0003231;GO:0051234;GO:0044338;GO:0050896;GO:0051960;GO:0046822;GO:0046823;GO:0051649;GO:0051247;GO:0070887;GO:0044699;GO:0032880;GO:0090287;GO:0071375;GO:0010562;GO:0051246;GO:0090288;GO:0031399;GO:0021953;GO:1901700;GO:1902593;GO:0072594;GO:0071396;GO:0042493;GO:1902680;GO:0033365;GO:0048731;GO:0016331;GO:0030323;GO:0030324;GO:0001649;GO:1901360;GO:0030178;GO:0030901;GO:0017038;GO:0045935;GO:0045934;GO:0030182;GO:0001738;GO:0007267;GO:0042221;GO:0035295;GO:0001736;GO:0044238;GO:0044237;GO:0019220;GO:0019222;GO:0032386;GO:0048584;GO:0048583;GO:0030111;GO:0060322;GO:1901362;GO:0048863;GO:0009968;GO:0009966;GO:0009967;GO:0048513;GO:0048518;GO:0048519;GO:0072497;GO:0006606;GO:0006605;GO:0045184;GO:0032268;GO:0043434;GO:0007178;GO:0044700;GO:0044707;GO:0010243;GO:0016055;GO:0060828;GO:0022607;GO:0022603;GO:0097659;GO:0090101;GO:0031670;GO:0048644;GO:0048646;GO:0006810;GO:0042308;GO:0034654;GO:0042306;GO:0030278;GO:1900181;GO:1900180;GO:0044271;GO:0007420;GO:0046907;GO:0031401;GO:0006355;GO:0006357;GO:0006351;GO:0032774;GO:0030154;GO:0061061;GO:1904953;GO:1904950;GO:0009719;GO:0006139;GO:0032270;GO:0060562;GO:0043009;GO:0032502;GO:0032501;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0032870;GO:0044744;GO:0032879;GO:0016482;GO:0071363;GO:0071407;GO:0051253;GO:0051252;GO:0051254;GO:0034504;GO:0071704;GO:0071310;GO:0048729;GO:0071702;GO:0007584;GO:0034613;GO:0006913;GO:1902679;GO:0044339;GO:0009058;GO:0009059;GO:0051170;GO:0051171;GO:0051172;GO:0051173;GO:0051179;GO:1902578;GO:0051641;GO:0003149;GO:1901652;GO:1901653;GO:1902582;GO:1902580;GO:0080090;GO:0007517;GO:0010605;GO:0010604;GO:0070727;GO:1904590;GO:0060255;GO:0045995;GO:0030514;GO:0035567;GO:0030510;GO:0042249;GO:0060412;GO:0060411;GO:0060415;GO:1903650;GO:1901576;GO:0045937;GO:0016043;GO:0065007;GO:0014070;GO:0001841;GO:0065009;GO:0036211;GO:0008150;GO:0008152;GO:0019438;GO:1901698;GO:1901699;GO:0071772;GO:0071773;GO:0050808;GO:0016310;GO:0035148;GO:0023056;GO:0044249;GO:0034641;GO:0009792;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010647;GO:0009653;GO:0022008;GO:0007416;GO:0007417;GO:0007507;GO:0060429;GO:1904948;GO:0045595;GO:0045892;GO:0045893;GO:0051091;GO:0051090;GO:0009725;GO:0043170;GO:0010628;GO:0009790;GO:0071495;GO:0009991;GO:0031328;GO:0031327;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0072175;GO:0071496;GO:0002009;GO:0071417;GO:1903508;GO:0010467;GO:0010468;GO:0071295;GO:0007154;GO:0048699;GO:0007399;GO:0044085;GO:0071305;GO:0048286;GO:0015031;GO:0001932;GO:0001934; regulation of intracellular protein transport;nuclear transport;regulation of transport;ossification;outflow tract morphogenesis;muscular septum morphogenesis;cellular response to stimulus;epithelial cell differentiation;negative regulation of response to stimulus;respiratory system development;negative regulation of intracellular transport;neural tube closure;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to external stimulus;BMP signaling pathway;protein metabolic process;circulatory system development;cardiovascular system development;regulation of protein import;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;positive regulation of biosynthetic process;positive regulation of canonical Wnt signaling pathway;negative regulation of catenin import into nucleus;positive regulation of Wnt signaling pathway;catenin import into nucleus;regulation of catenin import into nucleus;regulation of protein transport;negative regulation of protein transport;regulation of biological process;cardiac chamber development;cardiac chamber morphogenesis;intracellular protein transport;cellular component organization or biogenesis;heterocycle biosynthetic process;regulation of establishment of protein localization;regulation of cytoplasmic transport;tissue development;tube closure;macromolecule modification;RNA metabolic process;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;cellular developmental process;response to alcohol;negative regulation of macromolecule biosynthetic process;cellular response to alcohol;heart morphogenesis;regulation of cellular protein localization;regulation of phosphorus metabolic process;negative regulation of cellular protein localization;response to vitamin;tube morphogenesis;regulation of cellular localization;hard palate development;palate development;multicellular organism development;response to lipid;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;embryonic morphogenesis;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;neural tube development;regulation of nucleobase-containing compound metabolic process;negative regulation of intracellular protein transport;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;embryonic epithelial tube formation;cellular response to oxygen-containing compound;cardiac septum development;dopaminergic neuron differentiation;anatomical structure development;phosphate-containing compound metabolic process;regulation of multicellular organismal development;regulation of organ morphogenesis;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;protein localization;establishment of tissue polarity;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;response to growth factor;regulation of osteoblast differentiation;positive regulation of molecular function;macromolecule localization;negative regulation of transport;regulation of RNA biosynthetic process;response to organic substance;primary neural tube formation;cellular response to extracellular stimulus;cellular response to nutrient levels;establishment of planar polarity involved in neural tube closure;regulation of establishment of planar polarity;negative regulation of signaling;planar cell polarity pathway involved in neural tube closure;regulation of establishment of planar polarity involved in neural tube closure;response to nutrient levels;negative regulation of canonical Wnt signaling pathway;regulation of protein targeting;ventricular septum development;protein phosphorylation;negative regulation of gene expression;nitrogen compound metabolic process;response to vitamin D;cellular protein metabolic process;regulation of cell communication;cellular macromolecule metabolic process;transcription from RNA polymerase II promoter;organ morphogenesis;regulation of developmental process;regulation of biosynthetic process;autocrine signaling;regulation of cellular process;Wnt signaling pathway, planar cell polarity pathway;canonical Wnt signaling pathway;regulation of multicellular organismal process;cardiac ventricle development;establishment of localization;canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation;response to stimulus;regulation of nervous system development;regulation of nucleocytoplasmic transport;negative regulation of nucleocytoplasmic transport;establishment of localization in cell;positive regulation of protein metabolic process;cellular response to chemical stimulus;single-organism process;regulation of protein localization;regulation of cellular response to growth factor stimulus;cellular response to peptide hormone stimulus;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;negative regulation of cellular response to growth factor stimulus;regulation of protein modification process;central nervous system neuron differentiation;response to oxygen-containing compound;single-organism nuclear import;establishment of protein localization to organelle;cellular response to lipid;response to drug;positive regulation of RNA biosynthetic process;protein localization to organelle;system development;morphogenesis of embryonic epithelium;respiratory tube development;lung development;osteoblast differentiation;organic cyclic compound metabolic process;negative regulation of Wnt signaling pathway;midbrain development;protein import;positive regulation of nucleobase-containing compound metabolic process;negative regulation of nucleobase-containing compound metabolic process;neuron differentiation;morphogenesis of a polarized epithelium;cell-cell signaling;response to chemical;tube development;establishment of planar polarity;primary metabolic process;cellular metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;regulation of intracellular transport;positive regulation of response to stimulus;regulation of response to stimulus;regulation of Wnt signaling pathway;head development;organic cyclic compound biosynthetic process;stem cell differentiation;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;animal organ development;positive regulation of biological process;negative regulation of biological process;mesenchymal stem cell differentiation;protein import into nucleus;protein targeting;establishment of protein localization;regulation of cellular protein metabolic process;response to peptide hormone;transmembrane receptor protein serine/threonine kinase signaling pathway;single organism signaling;single-multicellular organism process;response to organonitrogen compound;Wnt signaling pathway;regulation of canonical Wnt signaling pathway;cellular component assembly;regulation of anatomical structure morphogenesis;nucleic acid-templated transcription;negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway;cellular response to nutrient;muscle organ morphogenesis;anatomical structure formation involved in morphogenesis;transport;negative regulation of protein import into nucleus;nucleobase-containing compound biosynthetic process;regulation of protein import into nucleus;regulation of ossification;negative regulation of protein localization to nucleus;regulation of protein localization to nucleus;cellular nitrogen compound biosynthetic process;brain development;intracellular transport;positive regulation of protein modification process;regulation of transcription, DNA-templated;regulation of transcription from RNA polymerase II promoter;transcription, DNA-templated;RNA biosynthetic process;cell differentiation;muscle structure development;Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;negative regulation of establishment of protein localization;response to endogenous stimulus;nucleobase-containing compound metabolic process;positive regulation of cellular protein metabolic process;epithelial tube morphogenesis;chordate embryonic development;developmental process;multicellular organismal process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to hormone stimulus;protein targeting to nucleus;regulation of localization;cytosolic transport;cellular response to growth factor stimulus;cellular response to organic cyclic compound;negative regulation of RNA metabolic process;regulation of RNA metabolic process;positive regulation of RNA metabolic process;protein localization to nucleus;organic substance metabolic process;cellular response to organic substance;tissue morphogenesis;organic substance transport;response to nutrient;cellular protein localization;nucleocytoplasmic transport;negative regulation of RNA biosynthetic process;canonical Wnt signaling pathway involved in osteoblast differentiation;biosynthetic process;macromolecule biosynthetic process;nuclear import;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;localization;single-organism localization;cellular localization;membranous septum morphogenesis;response to peptide;cellular response to peptide;single-organism intracellular transport;single-organism cellular localization;regulation of primary metabolic process;muscle organ development;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;negative regulation of protein import;regulation of macromolecule metabolic process;regulation of embryonic development;negative regulation of BMP signaling pathway;non-canonical Wnt signaling pathway;regulation of BMP signaling pathway;establishment of planar polarity of embryonic epithelium;ventricular septum morphogenesis;cardiac septum morphogenesis;muscle tissue morphogenesis;negative regulation of cytoplasmic transport;organic substance biosynthetic process;positive regulation of phosphate metabolic process;cellular component organization;biological regulation;response to organic cyclic compound;neural tube formation;regulation of molecular function;protein modification process;biological_process;metabolic process;aromatic compound biosynthetic process;response to nitrogen compound;cellular response to nitrogen compound;response to BMP;cellular response to BMP stimulus;synapse organization;phosphorylation;tube formation;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;anatomical structure morphogenesis;neurogenesis;synapse assembly;central nervous system development;heart development;epithelium development;midbrain dopaminergic neuron differentiation;regulation of cell differentiation;negative regulation of transcription, DNA-templated;positive regulation of transcription, DNA-templated;positive regulation of sequence-specific DNA binding transcription factor activity;regulation of sequence-specific DNA binding transcription factor activity;response to hormone;macromolecule metabolic process;positive regulation of gene expression;embryo development;cellular response to endogenous stimulus;response to extracellular stimulus;positive regulation of cellular biosynthetic process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;epithelial tube formation;cellular response to external stimulus;morphogenesis of an epithelium;cellular response to organonitrogen compound;positive regulation of nucleic acid-templated transcription;gene expression;regulation of gene expression;cellular response to vitamin;cell communication;generation of neurons;nervous system development;cellular component biogenesis;cellular response to vitamin D;lung alveolus development;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation; 6;6;4;4;4;6;3;6;3;5;4;6;4;7;7;3;6;4;5;5;6;3;3;4;4;6;6;5;6;7;5;4;2;4;4;6;2;5;5;6;4;5;5;5;5;5;4;5;5;6;5;5;5;3;5;4;4;4;4;4;5;6;6;4;5;4;5;4;6;3;4;3;6;5;4;7;3;5;4;5;4;3;3;4;4;4;5;6;5;5;4;3;3;6;4;6;4;5;5;6;3;7;6;5;6;7;5;7;5;3;6;5;4;4;7;4;3;4;5;3;7;7;3;5;3;8;2;5;7;6;4;5;4;2;4;4;6;5;5;4;6;6;4;6;5;6;4;6;6;4;5;4;4;5;4;5;4;5;5;5;6;6;4;3;4;5;3;3;6;3;5;3;3;5;4;5;6;4;4;4;4;2;2;7;5;6;4;5;5;7;3;3;4;6;6;4;4;7;5;5;5;3;4;5;5;6;4;4;6;5;4;5;6;6;7;6;6;5;4;6;3;3;4;5;5;7;2;2;2;4;7;7;5;5;3;6;6;6;5;5;5;7;3;5;4;5;4;5;7;6;6;3;5;8;4;4;4;2;3;3;4;5;6;5;4;4;5;4;4;4;5;4;5;5;7;5;6;5;4;5;5;4;6;3;2;5;5;3;5;1;2;5;4;5;4;5;4;6;4;3;4;4;6;2;4;5;3;4;3;6;5;5;4;5;5;4;6;6;5;4;4;4;5;5;4;4;5;5;5;4;4;4;5;5;4;5;5;7;5;5;6;4;7;5;3;7;4;5;7;7; GO:0044425;GO:0070161;GO:0031224;GO:0005912;GO:0044464;GO:0071944;GO:0016021;GO:0016020;GO:0042995;GO:0043234;GO:0005924;GO:0005925;GO:0030054;GO:0030055;GO:0043005;GO:0009986;GO:1990909;GO:0005623;GO:0097458;GO:0005886;GO:0032991;GO:0005575; membrane part;anchoring junction;intrinsic component of membrane;adherens junction;cell part;cell periphery;integral component of membrane;membrane;cell projection;protein complex;cell-substrate adherens junction;focal adhesion;cell junction;cell-substrate junction;neuron projection;cell surface;Wnt signalosome;cell;neuron part;plasma membrane;macromolecular complex;cellular_component; 2;3;3;4;2;3;4;2;3;3;4;5;2;3;4;3;4;2;3;3;2;1; GO:0005488;GO:0099600;GO:0005109;GO:0005515;GO:0005102;GO:0060089;GO:0019904;GO:0003674;GO:0004888;GO:0030165;GO:0004930;GO:0001664;GO:0042813;GO:0017147;GO:0038023;GO:0004872;GO:0004871; binding;transmembrane receptor activity;frizzled binding;protein binding;receptor binding;molecular transducer activity;protein domain specific binding;molecular_function;transmembrane signaling receptor activity;PDZ domain binding;G-protein coupled receptor activity;G-protein coupled receptor binding;Wnt-activated receptor activity;Wnt-protein binding;signaling receptor activity;receptor activity;signal transducer activity; 2;4;6;3;4;2;4;1;4;5;5;5;5;4;3;3;2; K02432 map04310;map04390;map04550;map04916;map05166;map05200;map05205;map05217; Wnt signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Melanogenesis;HTLV-I infection;Pathways in cancer;Proteoglycans in cancer;Basal cell carcinoma; IPR020067;IPR017981;IPR000539;IPR015526;IPR026548; Frizzled domain;GPCR, family 2-like;Frizzled/Smoothened, transmembrane domain;Frizzled/secreted frizzled-related protein;Frizzled-1; plasma membrane Hs4503825 1335.0 T [T] Signal transduction mechanisms; Q5SVZ6 Zinc finger MYM-type protein 1 OS=Homo sapiens OX=9606 GN=ZMYM1 PE=1 SV=1 - [ZMYM1_HUMAN] 1.059 1.106 0.822 1.215 1.107 0.868 0.957504521 nan 1.097560976 nan 0.743218807 nan 0.784101174 nan GO:0043231;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0044424;GO:0043227;GO:0043226; intracellular membrane-bounded organelle;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle;intracellular part;membrane-bounded organelle;organelle; 4;5;2;2;3;1;3;3;3;2; GO:0043169;GO:0046872;GO:0046914;GO:0097159;GO:0003674;GO:0005488;GO:0003676;GO:0043167;GO:1901363;GO:0008270; cation binding;metal ion binding;transition metal ion binding;organic cyclic compound binding;molecular_function;binding;nucleic acid binding;ion binding;heterocyclic compound binding;zinc ion binding; 4;5;6;3;1;2;4;3;3;7; IPR012337;IPR025398;IPR011017;IPR008906;IPR010507; Ribonuclease H-like domain;Domain of unknown function DUF4371;TRASH domain;HAT, C-terminal dimerisation domain;Zinc finger, MYM-type; nucleus Hs13376121 943.0 R [R] General function prediction only; Q8WUU4 Zinc finger protein 296 OS=Homo sapiens OX=9606 GN=ZNF296 PE=1 SV=1 - [ZN296_HUMAN] 1.127 1.054 0.63 1.089 0.862 2.797 1.069259962 nan 1.263341067 nan 0.59772296 nan 3.244779582 nan GO:0080090;GO:0019222;GO:1901362;GO:1901360;GO:0010605;GO:0000003;GO:0048519;GO:0051704;GO:0060255;GO:0006366;GO:0007283;GO:2001141;GO:0046483;GO:0044703;GO:0044702;GO:0019438;GO:0009892;GO:0009890;GO:0006807;GO:0043170;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0016070;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:0010558;GO:0032774;GO:0019953;GO:0044249;GO:0034641;GO:0034645;GO:0044699;GO:0006139;GO:0000122;GO:0032501;GO:0048609;GO:0032504;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0045892;GO:0048232;GO:0051253;GO:0051252;GO:0010629;GO:0031327;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0007276;GO:2000112;GO:2000113;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045934;GO:0019219;GO:1902679;GO:0022414;GO:0009058;GO:0009059;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;negative regulation of macromolecule metabolic process;reproduction;negative regulation of biological process;multi-organism process;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;spermatogenesis;regulation of RNA biosynthetic process;heterocycle metabolic process;multi-organism reproductive process;single organism reproductive process;aromatic compound biosynthetic process;negative regulation of metabolic process;negative regulation of biosynthetic process;nitrogen compound metabolic process;macromolecule metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;RNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;negative regulation of macromolecule biosynthetic process;RNA biosynthetic process;sexual reproduction;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;negative regulation of transcription from RNA polymerase II promoter;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;negative regulation of transcription, DNA-templated;male gamete generation;negative regulation of RNA metabolic process;regulation of RNA metabolic process;negative regulation of gene expression;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;gamete generation;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;negative regulation of RNA biosynthetic process;reproductive process;biosynthetic process;macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;negative regulation of cellular process; 4;3;5;4;4;2;2;2;4;7;6;6;4;3;3;5;3;4;3;4;2;7;4;4;2;5;4;3;1;2;5;5;5;6;5;6;5;6;3;4;4;5;2;4;7;2;3;3;2;4;7;7;6;5;5;5;5;5;5;4;4;5;4;6;6;3;5;7;5;5;5;6;2;3;5;4;4;3;3;3; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0043226;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;nucleus;cell part;cell;intracellular;organelle;cellular_component; 4;3;3;3;5;2;2;3;2;1; GO:0001076;GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0000989;GO:0000988;GO:0043169;GO:0097159;GO:0043167;GO:0046872; transcription factor activity, RNA polymerase II transcription factor binding;heterocyclic compound binding;molecular_function;binding;nucleic acid binding;DNA binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;cation binding;organic cyclic compound binding;ion binding;metal ion binding; 4;3;1;2;4;5;3;2;4;3;3;5; IPR013087; Zinc finger C2H2-type; nucleus Hs21687252 969.0 R [R] General function prediction only; Q12872 Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3 - [SFSWA_HUMAN] 1.011 0.73 1.636 0.987 0.692 0.927 1.384931507 0.063778868 1.426300578 0.081711236 2.24109589 0.013366319 1.339595376 0.114334798 GO:0000245;GO:0019222;GO:0050684;GO:0050686;GO:1901362;GO:1901360;GO:0080090;GO:0010605;GO:0048519;GO:0060255;GO:2001141;GO:0046483;GO:0000395;GO:0000398;GO:0006376;GO:0019438;GO:0051253;GO:0022607;GO:0009892;GO:0006807;GO:0043170;GO:0097659;GO:1901576;GO:0000380;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:0071840;GO:0018130;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0009059;GO:0016070;GO:0016071;GO:0044271;GO:0006355;GO:0010556;GO:0006351;GO:1903311;GO:1903312;GO:0033119;GO:0032774;GO:0044249;GO:0034641;GO:0034645;GO:0048024;GO:0048025;GO:0006139;GO:0043484;GO:0022618;GO:0022613;GO:0008380;GO:0009987;GO:0006725;GO:1903506;GO:0045292;GO:0051252;GO:0010629;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0090304;GO:0034622;GO:0071826;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0010468;GO:0045934;GO:0019219;GO:0000375;GO:0009058;GO:0000377;GO:0051171;GO:0051172;GO:0044238;GO:0044237;GO:0044085;GO:0048523;GO:0006396;GO:0006397; spliceosomal complex assembly;regulation of metabolic process;regulation of mRNA processing;negative regulation of mRNA processing;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of primary metabolic process;negative regulation of macromolecule metabolic process;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of RNA biosynthetic process;heterocycle metabolic process;mRNA 5'-splice site recognition;mRNA splicing, via spliceosome;mRNA splice site selection;aromatic compound biosynthetic process;negative regulation of RNA metabolic process;cellular component assembly;negative regulation of metabolic process;nitrogen compound metabolic process;macromolecule metabolic process;nucleic acid-templated transcription;organic substance biosynthetic process;alternative mRNA splicing, via spliceosome;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;heterocycle biosynthetic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;macromolecule biosynthetic process;RNA metabolic process;mRNA metabolic process;cellular nitrogen compound biosynthetic process;regulation of transcription, DNA-templated;regulation of macromolecule biosynthetic process;transcription, DNA-templated;regulation of mRNA metabolic process;negative regulation of mRNA metabolic process;negative regulation of RNA splicing;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;regulation of mRNA splicing, via spliceosome;negative regulation of mRNA splicing, via spliceosome;nucleobase-containing compound metabolic process;regulation of RNA splicing;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;RNA splicing;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;mRNA cis splicing, via spliceosome;regulation of RNA metabolic process;negative regulation of gene expression;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;ribonucleoprotein complex subunit organization;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of gene expression;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;RNA splicing, via transesterification reactions;biosynthetic process;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;primary metabolic process;cellular metabolic process;cellular component biogenesis;negative regulation of cellular process;RNA processing;mRNA processing; 6;3;6;6;5;4;4;4;2;4;6;4;7;8;6;5;5;4;3;3;4;7;4;9;4;3;5;2;2;5;4;3;1;2;5;5;5;6;5;6;5;6;6;6;6;6;4;4;5;7;7;4;6;5;4;7;2;4;7;9;5;5;4;5;4;4;5;6;5;6;2;3;5;5;5;5;8;3;9;4;4;3;3;3;3;6;7; GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0043226;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575; intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;organelle;nucleus;cell part;cell;intracellular;cellular_component; 4;3;3;3;2;5;2;2;3;1; GO:1901363;GO:0003674;GO:0005488;GO:0003676;GO:0097159;GO:0003723; heterocyclic compound binding;molecular_function;binding;nucleic acid binding;organic cyclic compound binding;RNA binding; 3;1;2;4;3;5; IPR000061;IPR019147; SWAP/Surp;Suppressor of white apricot N-terminal domain; nucleus Hs4759102 1920.0 A [A] RNA processing and modification; Q7Z7A4 PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1 - [PXK_HUMAN] nan nan nan nan nan nan nan 0.006518376 nan 0.166565148 nan 0.162162345 nan 0.081024247 GO:0042391;GO:0051049;GO:0007268;GO:0023052;GO:0050804;GO:0023051;GO:0051336;GO:0050789;GO:0043269;GO:0032879;GO:0043086;GO:0051346;GO:0010646;GO:0065007;GO:0044699;GO:0044092;GO:0048519;GO:0065009;GO:0065008;GO:0050790;GO:0051051;GO:0032780;GO:0006811;GO:0006810;GO:0050794;GO:0006952;GO:0043271;GO:0044765;GO:0043462;GO:0008150;GO:0006954;GO:0007267;GO:0007154;GO:0051234;GO:0051179;GO:1902578;GO:0044700;GO:0098916;GO:0050896;GO:0006950;GO:0099536;GO:0044763;GO:0009987;GO:0099537; regulation of membrane potential;regulation of transport;synaptic transmission;signaling;modulation of synaptic transmission;regulation of signaling;regulation of hydrolase activity;regulation of biological process;regulation of ion transport;regulation of localization;negative regulation of catalytic activity;negative regulation of hydrolase activity;regulation of cell communication;biological regulation;single-organism process;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;regulation of biological quality;regulation of catalytic activity;negative regulation of transport;negative regulation of ATPase activity;ion transport;transport;regulation of cellular process;defense response;negative regulation of ion transport;single-organism transport;regulation of ATPase activity;biological_process;inflammatory response;cell-cell signaling;cell communication;establishment of localization;localization;single-organism localization;single organism signaling;anterograde trans-synaptic signaling;response to stimulus;response to stress;synaptic signaling;single-organism cellular process;cellular process;trans-synaptic signaling; 4;4;8;2;4;3;5;2;5;3;5;6;4;2;2;4;2;3;3;4;3;7;5;4;3;4;4;4;6;1;5;4;4;3;2;3;3;7;2;3;5;3;2;6; GO:0016020;GO:0043226;GO:0043229;GO:0043228;GO:0005815;GO:0043227;GO:0005737;GO:0044446;GO:0005634;GO:0044430;GO:0015630;GO:0005886;GO:0043234;GO:0032991;GO:0043231;GO:0043232;GO:0005856;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0071944;GO:0044424;GO:0044422; membrane;organelle;intracellular organelle;non-membrane-bounded organelle;microtubule organizing center;membrane-bounded organelle;cytoplasm;intracellular organelle part;nucleus;cytoskeletal part;microtubule cytoskeleton;plasma membrane;protein complex;macromolecular complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytoskeleton;cell part;cell;intracellular;cellular_component;cell periphery;intracellular part;organelle part; 2;2;3;3;5;3;4;3;5;4;6;3;3;2;4;4;5;2;2;3;1;3;3;2; GO:0008022;GO:0003674;GO:0005488;GO:0005543;GO:0043167;GO:0043168;GO:0008289;GO:0035091;GO:0005515; protein C-terminus binding;molecular_function;binding;phospholipid binding;ion binding;anion binding;lipid binding;phosphatidylinositol binding;protein binding; 4;1;2;4;3;4;3;5;3; K17543 IPR003124;IPR001683;IPR011009;IPR000719; WH2 domain;Phox homologous domain;Protein kinase-like domain;Protein kinase domain; nucleus Hs20469612 857.0 T [T] Signal transduction mechanisms; A0A0B4J1U3 Immunoglobulin lambda variable 1-36 OS=Homo sapiens OX=9606 GN=IGLV1-36 PE=3 SV=5 - [LV136_HUMAN] 1.243 1.048 0.916 1.087 0.972 0.803 1.186068702 nan 1.118312757 nan 0.874045802 nan 0.826131687 nan IPR007110;IPR013106; Immunoglobulin-like domain;Immunoglobulin V-set domain; extracellular P11216 Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5 - [PYGB_HUMAN] 1.127 1.419 0.662 0.803 1.384 0.43 0.794221283 nan 0.580202312 nan 0.466525722 nan 0.310693642 nan GO:0016052;GO:0044042;GO:0044248;GO:0044710;GO:0009251;GO:0006091;GO:0043170;GO:0044699;GO:0044247;GO:0044264;GO:0044262;GO:0044260;GO:0005980;GO:0071704;GO:0006112;GO:0006073;GO:0044724;GO:0044281;GO:0044712;GO:0006006;GO:0009987;GO:0019318;GO:1901575;GO:0000272;GO:0008150;GO:0008152;GO:0044723;GO:0009056;GO:0009057;GO:0055114;GO:0044275;GO:0044238;GO:0005975;GO:0015980;GO:0005977;GO:0005976;GO:0005996;GO:0044763;GO:0044237; carbohydrate catabolic process;glucan metabolic process;cellular catabolic process;single-organism metabolic process;glucan catabolic process;generation of precursor metabolites and energy;macromolecule metabolic process;single-organism process;cellular polysaccharide catabolic process;cellular polysaccharide metabolic process;cellular carbohydrate metabolic process;cellular macromolecule metabolic process;glycogen catabolic process;organic substance metabolic process;energy reserve metabolic process;cellular glucan metabolic process;single-organism carbohydrate catabolic process;small molecule metabolic process;single-organism catabolic process;glucose metabolic process;cellular process;hexose metabolic process;organic substance catabolic process;polysaccharide catabolic process;biological_process;metabolic process;single-organism carbohydrate metabolic process;catabolic process;macromolecule catabolic process;oxidation-reduction process;cellular carbohydrate catabolic process;primary metabolic process;carbohydrate metabolic process;energy derivation by oxidation of organic compounds;glycogen metabolic process;polysaccharide metabolic process;monosaccharide metabolic process;single-organism cellular process;cellular metabolic process; 5;6;4;3;7;4;4;2;6;5;4;4;6;3;5;6;5;4;4;7;2;6;4;6;1;2;4;3;5;4;5;3;4;4;5;5;5;3;3; GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0016020;GO:0043230;GO:1903561;GO:0031982;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421; membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;membrane;extracellular organelle;extracellular vesicle;vesicle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part; 3;2;4;4;2;3;3;4;2;2;3;1;2;3;2; GO:0005488;GO:1901363;GO:0003674;GO:0008184;GO:0043167;GO:0016740;GO:0003824;GO:0016758;GO:0048037;GO:0097159;GO:0004645;GO:0043168;GO:0016757;GO:0030170; binding;heterocyclic compound binding;molecular_function;glycogen phosphorylase activity;ion binding;transferase activity;catalytic activity;transferase activity, transferring hexosyl groups;cofactor binding;organic cyclic compound binding;phosphorylase activity;anion binding;transferase activity, transferring glycosyl groups;pyridoxal phosphate binding; 2;3;1;7;3;3;2;5;3;3;6;4;4;4; K00688 map00500;map01100;map01110;map04910;map04922;map04931; Starch and sucrose metabolism;Metabolic pathways;Biosynthesis of secondary metabolites;Insulin signaling pathway;Glucagon signaling pathway;Insulin resistance; IPR000811;IPR035090;IPR011833; Glycosyl transferase, family 35;Phosphorylase pyridoxal-phosphate attachment site;Glycogen/starch/alpha-glucan phosphorylase; cytosol Hs21361370 1759.0 G [G] Carbohydrate transport and metabolism; Q9H7Z3 Protein NRDE2 homolog OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3 - [NRDE2_HUMAN] 1.067 1.202 0.837 1.12 1.062 0.83 0.887687188 0.170610798 1.054613936 0.488823824 0.696339434 0.036572795 0.781544256 0.342788909 IPR013633;IPR011990; siRNA-mediated silencing protein NRDE-2;Tetratricopeptide-like helical domain; nucleus Hs13540482 1450.0 S [S] Function unknown; O00750 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2 - [P3C2B_HUMAN] 1.169 1.23 0.785 1.163 0.948 0.888 0.950406504 nan 1.226793249 nan 0.638211382 nan 0.936708861 nan GO:0007165;GO:0044710;GO:0044711;GO:0006661;GO:0046488;GO:0046486;GO:0044700;GO:0048870;GO:0044281;GO:0051716;GO:0006928;GO:0051674;GO:0035556;GO:0050789;GO:1901576;GO:0065007;GO:0019637;GO:0016477;GO:0006629;GO:0050794;GO:0008150;GO:0008152;GO:0090407;GO:0048017;GO:0008654;GO:0043491;GO:0050896;GO:0044249;GO:0023052;GO:0044699;GO:0006644;GO:0009987;GO:0014065;GO:0044255;GO:0046474;GO:0006650;GO:0045017;GO:0071704;GO:0048015;GO:0009058;GO:0044763;GO:0036092;GO:0007154;GO:0051179;GO:0008610;GO:0040011;GO:0044238;GO:0044237;GO:0006796;GO:0006793; signal transduction;single-organism metabolic process;single-organism biosynthetic process;phosphatidylinositol biosynthetic process;phosphatidylinositol metabolic process;glycerolipid metabolic process;single organism signaling;cell motility;small molecule metabolic process;cellular response to stimulus;movement of cell or subcellular component;localization of cell;intracellular signal transduction;regulation of biological process;organic substance biosynthetic process;biological regulation;organophosphate metabolic process;cell migration;lipid metabolic process;regulation of cellular process;biological_process;metabolic process;organophosphate biosynthetic process;inositol lipid-mediated signaling;phospholipid biosynthetic process;protein kinase B signaling;response to stimulus;cellular biosynthetic process;signaling;single-organism process;phospholipid metabolic process;cellular process;phosphatidylinositol 3-kinase signaling;cellular lipid metabolic process;glycerophospholipid biosynthetic process;glycerophospholipid metabolic process;glycerolipid biosynthetic process;organic substance metabolic process;phosphatidylinositol-mediated signaling;biosynthetic process;single-organism cellular process;phosphatidylinositol-3-phosphate biosynthetic process;cell communication;localization;lipid biosynthetic process;locomotion;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process; 4;3;4;7;7;5;3;3;4;3;4;3;5;2;4;2;4;4;4;3;1;2;5;6;5;6;2;4;2;2;5;2;8;4;6;6;5;3;7;3;3;8;4;2;5;2;3;3;5;4; GO:0005783;GO:0031982;GO:0005942;GO:0016023;GO:0031988;GO:1902494;GO:1990234;GO:0043234;GO:0043231;GO:0005829;GO:0044424;GO:0044425;GO:0043229;GO:0043227;GO:0097708;GO:0044444;GO:0012505;GO:0016020;GO:0019898;GO:0005737;GO:0031410;GO:0005634;GO:0061695;GO:0044464;GO:0005623;GO:0005622;GO:0030139;GO:0071944;GO:0043226;GO:0005886;GO:0032991;GO:0005575;GO:0098796; endoplasmic reticulum;vesicle;phosphatidylinositol 3-kinase complex;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;catalytic complex;transferase complex;protein complex;intracellular membrane-bounded organelle;cytosol;intracellular part;membrane part;intracellular organelle;membrane-bounded organelle;intracellular vesicle;cytoplasmic part;endomembrane system;membrane;extrinsic component of membrane;cytoplasm;cytoplasmic vesicle;nucleus;transferase complex, transferring phosphorus-containing groups;cell part;cell;intracellular;endocytic vesicle;cell periphery;organelle;plasma membrane;macromolecular complex;cellular_component;membrane protein complex; 4;4;4;5;5;4;5;3;4;5;3;2;3;3;4;4;3;2;3;4;5;5;6;2;2;3;6;3;2;3;2;1;3; GO:1901363;GO:0005543;GO:0016740;GO:0017076;GO:0097367;GO:0016773;GO:0003674;GO:0005488;GO:0035004;GO:0035005;GO:1901265;GO:0032549;GO:0005524;GO:0043168;GO:0016303;GO:0016301;GO:0016307;GO:0003824;GO:0035091;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0000166;GO:0043167;GO:0008289;GO:0030554;GO:0052742;GO:0016772;GO:0097159;GO:0001883;GO:0001882;GO:0001727;GO:0036094; heterocyclic compound binding;phospholipid binding;transferase activity;purine nucleotide binding;carbohydrate derivative binding;phosphotransferase activity, alcohol group as acceptor;molecular_function;binding;phosphatidylinositol 3-kinase activity;1-phosphatidylinositol-4-phosphate 3-kinase activity;nucleoside phosphate binding;ribonucleoside binding;ATP binding;anion binding;1-phosphatidylinositol-3-kinase activity;kinase activity;phosphatidylinositol phosphate kinase activity;catalytic activity;phosphatidylinositol binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;ion binding;lipid binding;adenyl nucleotide binding;phosphatidylinositol kinase activity;transferase activity, transferring phosphorus-containing groups;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;lipid kinase activity;small molecule binding; 3;4;3;5;3;5;1;2;6;7;4;5;6;4;7;5;6;2;5;6;5;6;4;5;4;3;3;6;6;4;3;5;4;6;3; K00923 map00562;map01100;map04070; Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system; IPR016024;IPR001683;IPR011009;IPR002420;IPR029071;IPR018936;IPR001263;IPR000403;IPR000341;IPR000008;IPR015433; Armadillo-type fold;Phox homologous domain;Protein kinase-like domain;Phosphatidylinositol 3-kinase, C2 domain;Ubiquitin-related domain;Phosphatidylinositol 3/4-kinase, conserved site;Phosphoinositide 3-kinase, accessory (PIK) domain;Phosphatidylinositol 3-/4-kinase, catalytic domain;Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain;C2 domain;Phosphatidylinositol kinase; nucleus Hs15451926 3400.0 T [T] Signal transduction mechanisms; O43482 Protein Mis18-beta OS=Homo sapiens OX=9606 GN=OIP5 PE=1 SV=2 - [MS18B_HUMAN] 1.039 1.122 1.128 0.996 1.024 0.505 0.926024955 nan 0.97265625 nan 1.005347594 nan 0.493164063 nan GO:0034728;GO:0034080;GO:0022607;GO:0070271;GO:0043933;GO:0000280;GO:0034724;GO:0031055;GO:0016043;GO:0031497;GO:0034622;GO:0007067;GO:0071840;GO:0071822;GO:0006325;GO:0043486;GO:0071103;GO:0043044;GO:0022402;GO:0006323;GO:0065003;GO:0044699;GO:0065004;GO:0048285;GO:0071824;GO:0006461;GO:0000278;GO:0044763;GO:0051301;GO:0034508;GO:0009987;GO:0008150;GO:1903047;GO:0007154;GO:0006996;GO:0007049;GO:0051276;GO:0006338;GO:0006336;GO:0006334;GO:0006333;GO:1902589;GO:0044085;GO:0061641;GO:0016568; nucleosome organization;CENP-A containing nucleosome assembly;cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;nuclear division;DNA replication-independent nucleosome organization;chromatin remodeling at centromere;cellular component organization;chromatin assembly;cellular macromolecular complex assembly;mitotic nuclear division;cellular component organization or biogenesis;protein complex subunit organization;chromatin organization;histone exchange;DNA conformation change;ATP-dependent chromatin remodeling;cell cycle process;DNA packaging;macromolecular complex assembly;single-organism process;protein-DNA complex assembly;organelle fission;protein-DNA complex subunit organization;protein complex assembly;mitotic cell cycle;single-organism cellular process;cell division;centromere complex assembly;cellular process;biological_process;mitotic cell cycle process;cell communication;organelle organization;cell cycle;chromosome organization;chromatin remodeling;DNA replication-independent nucleosome assembly;nucleosome assembly;chromatin assembly or disassembly;single-organism organelle organization;cellular component biogenesis;CENP-A containing chromatin organization;chromatin modification; 6;7;4;4;4;6;7;8;3;6;6;5;2;5;5;7;6;8;4;7;5;2;6;5;5;5;5;3;4;6;2;1;5;4;4;4;5;7;7;6;6;4;3;6;6; GO:0043232;GO:0031974;GO:0043229;GO:0043228;GO:0010369;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0016604;GO:0044451;GO:0005694;GO:0000785;GO:0015030;GO:0000775;GO:0098687;GO:0043231;GO:0032991;GO:0043233;GO:0031981;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044428;GO:0044422;GO:0044424;GO:0044427;GO:0005654;GO:0005634; intracellular non-membrane-bounded organelle;membrane-enclosed lumen;intracellular organelle;non-membrane-bounded organelle;chromocenter;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;nuclear body;nucleoplasm part;chromosome;chromatin;Cajal body;chromosome, centromeric region;chromosomal region;intracellular membrane-bounded organelle;macromolecular complex;organelle lumen;nuclear lumen;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;nuclear part;organelle part;intracellular part;chromosomal part;nucleoplasm;nucleus; 4;2;3;3;6;3;2;4;3;6;5;5;3;7;6;5;4;2;3;5;2;2;3;1;4;4;2;3;4;5;5; K11565 IPR004910;IPR034752; Yippee/Mis18/Cereblon;Mis18 domain; cytosol, nucleus Q86WZ0 HEAT repeat-containing protein 4 OS=Homo sapiens OX=9606 GN=HEATR4 PE=2 SV=2 - [HEAT4_HUMAN] 0.968 1.418 0.758 0.976 1.256 0.857 0.682651622 0.000622272 0.777070064 0.004416848 0.534555712 5.59E-05 0.682324841 0.007099072 IPR000357;IPR016024;IPR011989; HEAT repeat;Armadillo-type fold;Armadillo-like helical; nucleus 113474652 70.9 T [T] Signal transduction mechanisms; COG5635 Predicted NTPase, NACHT family domain Q53SF7 Cordon-bleu protein-like 1 OS=Homo sapiens OX=9606 GN=COBLL1 PE=1 SV=2 - [COBL1_HUMAN] 0.892 0.928 1.141 1.018 1.127 1.235 0.961206897 nan 0.903283052 nan 1.229525862 nan 1.095829636 nan GO:0022607;GO:0070271;GO:0043933;GO:0030036;GO:0051639;GO:0034622;GO:0071840;GO:0071822;GO:0016043;GO:0065003;GO:0044699;GO:0009987;GO:0030029;GO:0007015;GO:0006461;GO:0008154;GO:0008150;GO:0030041;GO:0043623;GO:0006996;GO:0051258;GO:0007010;GO:1902589;GO:0044085;GO:0044763; cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;actin cytoskeleton organization;actin filament network formation;cellular macromolecular complex assembly;cellular component organization or biogenesis;protein complex subunit organization;cellular component organization;macromolecular complex assembly;single-organism process;cellular process;actin filament-based process;actin filament organization;protein complex assembly;actin polymerization or depolymerization;biological_process;actin filament polymerization;cellular protein complex assembly;organelle organization;protein polymerization;cytoskeleton organization;single-organism organelle organization;cellular component biogenesis;single-organism cellular process; 4;4;4;5;7;6;2;5;3;5;2;2;4;6;5;7;1;8;6;4;7;5;4;3;3; GO:0043227;GO:0043226;GO:0070062;GO:0005576;GO:0043230;GO:1903561;GO:0031982;GO:0005575;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular region;extracellular organelle;extracellular vesicle;vesicle;cellular_component;extracellular region part; 3;2;4;2;3;3;4;1;2; GO:0003674;GO:0005488;GO:0003779;GO:0003785;GO:0008092;GO:0005515; molecular_function;binding;actin binding;actin monomer binding;cytoskeletal protein binding;protein binding; 1;2;5;6;4;3; IPR003124;IPR019025; WH2 domain;Cordon-bleu, ubiquitin-like domain; nucleus A2RUT3 Transmembrane protein 89 OS=Homo sapiens OX=9606 GN=TMEM89 PE=2 SV=1 - [TMM89_HUMAN] 1.003 0.972 1.273 0.994 0.891 0.999 1.031893004 nan 1.115600449 nan 1.309670782 nan 1.121212121 nan GO:0043231;GO:0016021;GO:0016020;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0043226;GO:0044424;GO:0044425;GO:0043227;GO:0005634;GO:0031224; intracellular membrane-bounded organelle;integral component of membrane;membrane;cell part;cell;intracellular;cellular_component;intracellular organelle;organelle;intracellular part;membrane part;membrane-bounded organelle;nucleus;intrinsic component of membrane; 4;4;2;2;2;3;1;3;2;3;2;3;5;3; IPR028069; Transmembrane protein 89; extracellular P49908 Selenoprotein P OS=Homo sapiens OX=9606 GN=SELENOP PE=1 SV=3 - [SEPP1_HUMAN] 0.904 1.06 1.004 0.87 1.083 1.215 0.852830189 0.007516283 0.8033241 0.064648864 0.947169811 0.593032893 1.121883657 0.687805236 GO:0019953;GO:0007610;GO:0009791;GO:0060322;GO:0001887;GO:0007275;GO:0044699;GO:0007417;GO:0048513;GO:0051704;GO:0032502;GO:0007626;GO:0032501;GO:0009987;GO:0044767;GO:0022414;GO:0006950;GO:0008150;GO:0008152;GO:0048731;GO:0040007;GO:0006979;GO:0000003;GO:0044703;GO:0007420;GO:0044707;GO:0050896;GO:0048856;GO:0044237;GO:0007399; sexual reproduction;behavior;post-embryonic development;head development;selenium compound metabolic process;multicellular organism development;single-organism process;central nervous system development;animal organ development;multi-organism process;developmental process;locomotory behavior;multicellular organismal process;cellular process;single-organism developmental process;reproductive process;response to stress;biological_process;metabolic process;system development;growth;response to oxidative stress;reproduction;multi-organism reproductive process;brain development;single-multicellular organism process;response to stimulus;anatomical structure development;cellular metabolic process;nervous system development; 3;2;4;4;4;4;2;5;4;2;2;3;2;2;3;2;3;1;2;4;2;4;2;3;4;3;2;3;3;5; GO:0043227;GO:0005615;GO:0043226;GO:0031982;GO:1903561;GO:0043230;GO:0070062;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;extracellular space;organelle;vesicle;extracellular vesicle;extracellular organelle;extracellular exosome;cellular_component;extracellular region;extracellular region part; 3;3;2;4;3;3;4;1;2;2; GO:0003674;GO:0005488;GO:0008430; molecular_function;binding;selenium binding; 1;2;3; IPR007671;IPR007672; Selenoprotein P, N-terminal;Selenoprotein P, C-terminal; extracellular Q7Z4N8 Prolyl 4-hydroxylase subunit alpha-3 OS=Homo sapiens OX=9606 GN=P4HA3 PE=1 SV=1 - [P4HA3_HUMAN] 0.902 0.946 0.851 0.936 1.12 3.163 0.953488372 0.662260276 0.835714286 0.072994307 0.899577167 0.393290345 2.824107143 0.061624243 GO:0005783;GO:0044464;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0012505;GO:0005623;GO:0044432;GO:0005737;GO:0044446;GO:0005788;GO:0043231;GO:0043233;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0044424;GO:0044422; endoplasmic reticulum;cell part;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;endomembrane system;cell;endoplasmic reticulum part;cytoplasm;intracellular organelle part;endoplasmic reticulum lumen;intracellular membrane-bounded organelle;organelle lumen;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;intracellular part;organelle part; 4;2;2;3;3;2;3;2;4;4;3;5;4;3;3;1;4;4;3;2; GO:0030246;GO:0003674;GO:0005488;GO:0016701;GO:0016491;GO:0043168;GO:0031418;GO:0046914;GO:0016706;GO:0004656;GO:0016705;GO:0016702;GO:0043167;GO:0019798;GO:0005506;GO:0046872;GO:0043169;GO:0036094;GO:0003824;GO:0031545;GO:0031543;GO:0051213;GO:0043177;GO:0031406;GO:0019842;GO:0048029; carbohydrate binding;molecular_function;binding;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;oxidoreductase activity;anion binding;L-ascorbic acid binding;transition metal ion binding;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;procollagen-proline 4-dioxygenase activity;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;ion binding;procollagen-proline dioxygenase activity;iron ion binding;metal ion binding;cation binding;small molecule binding;catalytic activity;peptidyl-proline 4-dioxygenase activity;peptidyl-proline dioxygenase activity;dioxygenase activity;organic acid binding;carboxylic acid binding;vitamin binding;monosaccharide binding; 3;1;2;4;3;4;5;6;5;8;4;5;3;7;7;5;4;3;2;7;6;4;4;5;4;4; K00472 map00330;map01100; Arginine and proline metabolism;Metabolic pathways; IPR006620;IPR013547;IPR005123;IPR011990; Prolyl 4-hydroxylase, alpha subunit;Prolyl 4-hydroxylase alpha-subunit, N-terminal;Oxoglutarate/iron-dependent dioxygenase;Tetratricopeptide-like helical domain; extracellular CE05811 333.0 E [E] Amino acid transport and metabolism; P68032 Actin, alpha cardiac muscle 1 OS=Homo sapiens OX=9606 GN=ACTC1 PE=1 SV=1 - [ACTC_HUMAN] 0.973 1.049 0.777 1.332 1.244 0.777 0.927550048 0.635394562 1.07073955 0.401637725 0.740705434 0.018082501 0.624598071 0.010917092 GO:0019222;GO:0048468;GO:0003012;GO:0003013;GO:0003015;GO:0071840;GO:0007517;GO:0010604;GO:0048869;GO:0043067;GO:0048513;GO:0048518;GO:0048519;GO:0006936;GO:0060255;GO:0060548;GO:0003007;GO:0030048;GO:0010033;GO:0003008;GO:0044707;GO:0072358;GO:0042692;GO:0022607;GO:0009893;GO:0042493;GO:0006928;GO:0010628;GO:0072132;GO:0050789;GO:0016043;GO:0065007;GO:0048644;GO:0048646;GO:0009887;GO:0008015;GO:0009888;GO:0050794;GO:0008150;GO:1901700;GO:0008152;GO:0012501;GO:0050896;GO:0060415;GO:0097305;GO:0072359;GO:0030154;GO:0010927;GO:0006941;GO:0060047;GO:0060485;GO:0061061;GO:0009653;GO:0060048;GO:0044699;GO:0033275;GO:0032502;GO:0055001;GO:0055002;GO:0014866;GO:0055006;GO:0007507;GO:0055008;GO:0009987;GO:0043066;GO:0090131;GO:0090130;GO:0048738;GO:0048731;GO:0055013;GO:0031032;GO:0043933;GO:0030240;GO:0030036;GO:0043170;GO:0014706;GO:0032501;GO:0051146;GO:0008219;GO:0010941;GO:0007275;GO:0071822;GO:0042981;GO:0055007;GO:0032989;GO:0071704;GO:0010467;GO:0048729;GO:0043069;GO:0010468;GO:0030029;GO:0030239;GO:0006915;GO:0035051;GO:0044767;GO:0045471;GO:0044763;GO:0042221;GO:0070925;GO:0006996;GO:0007015;GO:0007010;GO:0055003;GO:0048856;GO:1902589;GO:0044085;GO:0060537;GO:0070252;GO:0048523; regulation of metabolic process;cell development;muscle system process;circulatory system process;heart process;cellular component organization or biogenesis;muscle organ development;positive regulation of macromolecule metabolic process;cellular developmental process;regulation of programmed cell death;animal organ development;positive regulation of biological process;negative regulation of biological process;muscle contraction;regulation of macromolecule metabolic process;negative regulation of cell death;heart morphogenesis;actin filament-based movement;response to organic substance;system process;single-multicellular organism process;cardiovascular system development;muscle cell differentiation;cellular component assembly;positive regulation of metabolic process;response to drug;movement of cell or subcellular component;positive regulation of gene expression;mesenchyme morphogenesis;regulation of biological process;cellular component organization;biological regulation;muscle organ morphogenesis;anatomical structure formation involved in morphogenesis;organ morphogenesis;blood circulation;tissue development;regulation of cellular process;biological_process;response to oxygen-containing compound;metabolic process;programmed cell death;response to stimulus;muscle tissue morphogenesis;response to alcohol;circulatory system development;cell differentiation;cellular component assembly involved in morphogenesis;striated muscle contraction;heart contraction;mesenchyme development;muscle structure development;anatomical structure morphogenesis;cardiac muscle contraction;single-organism process;actin-myosin filament sliding;developmental process;muscle cell development;striated muscle cell development;skeletal myofibril assembly;cardiac cell development;heart development;cardiac muscle tissue morphogenesis;cellular process;negative regulation of apoptotic process;mesenchyme migration;tissue migration;cardiac muscle tissue development;system development;cardiac muscle cell development;actomyosin structure organization;macromolecular complex subunit organization;skeletal muscle thin filament assembly;actin cytoskeleton organization;macromolecule metabolic process;striated muscle tissue development;multicellular organismal process;striated muscle cell differentiation;cell death;regulation of cell death;multicellular organism development;protein complex subunit organization;regulation of apoptotic process;cardiac muscle cell differentiation;cellular component morphogenesis;organic substance metabolic process;gene expression;tissue morphogenesis;negative regulation of programmed cell death;regulation of gene expression;actin filament-based process;myofibril assembly;apoptotic process;cardiocyte differentiation;single-organism developmental process;response to ethanol;single-organism cellular process;response to chemical;organelle assembly;organelle organization;actin filament organization;cytoskeleton organization;cardiac myofibril assembly;anatomical structure development;single-organism organelle organization;cellular component biogenesis;muscle tissue development;actin-mediated cell contraction;negative regulation of cellular process; 3;4;4;4;5;2;5;4;4;5;4;2;2;5;4;4;5;5;4;3;3;5;5;4;3;4;4;5;5;2;3;2;5;3;4;5;4;3;1;4;2;5;2;5;5;5;5;4;6;6;5;4;3;7;2;7;2;5;6;6;5;4;6;2;6;5;4;5;4;6;6;4;7;5;4;6;2;6;4;4;4;5;6;6;4;3;5;4;5;5;4;5;6;5;3;6;3;3;5;4;6;5;6;3;4;3;5;6;3; GO:0099512;GO:0099513;GO:0030055;GO:0016020;GO:0044297;GO:0042995;GO:0030016;GO:0043230;GO:0043232;GO:0098858;GO:0044424;GO:0044421;GO:0044422;GO:0030175;GO:0043229;GO:0005924;GO:0005925;GO:0043227;GO:0005856;GO:0031674;GO:0044430;GO:0030054;GO:0070161;GO:0031982;GO:0044446;GO:0044444;GO:0044449;GO:0015629;GO:0030017;GO:0031252;GO:0042643;GO:0042641;GO:0005737;GO:1903561;GO:0005912;GO:0044464;GO:0005623;GO:0005622;GO:0043228;GO:0070062;GO:0005576;GO:0030027;GO:0005884;GO:0005615;GO:0005575;GO:0043226;GO:0043292;GO:0072562; supramolecular fiber;polymeric cytoskeletal fiber;cell-substrate junction;membrane;cell body;cell projection;myofibril;extracellular organelle;intracellular non-membrane-bounded organelle;actin-based cell projection;intracellular part;extracellular region part;organelle part;filopodium;intracellular organelle;cell-substrate adherens junction;focal adhesion;membrane-bounded organelle;cytoskeleton;I band;cytoskeletal part;cell junction;anchoring junction;vesicle;intracellular organelle part;cytoplasmic part;contractile fiber part;actin cytoskeleton;sarcomere;cell leading edge;actomyosin, actin portion;actomyosin;cytoplasm;extracellular vesicle;adherens junction;cell part;cell;intracellular;non-membrane-bounded organelle;extracellular exosome;extracellular region;lamellipodium;actin filament;extracellular space;cellular_component;organelle;contractile fiber;blood microparticle; 2;3;3;2;3;3;6;3;4;4;3;2;2;5;3;4;5;3;5;4;4;2;3;4;3;4;3;6;4;3;5;5;4;3;4;2;2;3;3;4;2;4;4;3;1;2;5;3; GO:1901363;GO:0000166;GO:0035639;GO:0016818;GO:0097367;GO:0016817;GO:0005524;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:0032549;GO:0017076;GO:0016787;GO:0003824;GO:0036094;GO:0097159;GO:0016462;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0043167;GO:0030554;GO:0001883;GO:0001882;GO:0017111;GO:0043168; heterocyclic compound binding;nucleotide binding;purine ribonucleoside triphosphate binding;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;ATP binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;hydrolase activity;catalytic activity;small molecule binding;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;ion binding;adenyl nucleotide binding;purine nucleoside binding;nucleoside binding;nucleoside-triphosphatase activity;anion binding; 3;4;5;5;3;4;6;1;2;8;4;5;5;3;2;3;3;6;6;5;6;4;3;6;5;4;7;4; K12314 map04260;map04261;map05410;map05414; Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy; IPR020902;IPR004000;IPR004001; Actin/actin-like conserved site;Actin family;Actin, conserved site; cytoskeleton Hs4885049 789.0 Z [Z] Cytoskeleton; P04217 Alpha-1B-glycoprotein OS=Homo sapiens OX=9606 GN=A1BG PE=1 SV=4 - [A1BG_HUMAN] 1.048 0.937 0.991 1.095 0.943 1.38 1.11846318 6.51E-17 1.161187699 1.55E-39 1.057630736 5.17E-10 1.463414634 9.99E-39 GO:0043230;GO:0070062;GO:0005615;GO:0072562;GO:0044421;GO:0005575;GO:0005576;GO:1903561;GO:0043227;GO:0043226;GO:0031982; extracellular organelle;extracellular exosome;extracellular space;blood microparticle;extracellular region part;cellular_component;extracellular region;extracellular vesicle;membrane-bounded organelle;organelle;vesicle; 3;4;3;3;2;1;2;3;3;2;4; IPR003599;IPR007110;IPR013783;IPR016332;IPR003598; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor;Immunoglobulin subtype 2; extracellular P11597 Cholesteryl ester transfer protein OS=Homo sapiens OX=9606 GN=CETP PE=1 SV=2 - [CETP_HUMAN] 0.953 0.953 1.231 0.837 1.039 0.718 1 0.451159922 0.805582291 0.046441144 1.291710388 0.613806936 0.691049086 0.963697346 GO:0051049;GO:0006820;GO:0044281;GO:0034197;GO:0034196;GO:0071840;GO:0044710;GO:0048869;GO:0097006;GO:0033036;GO:0006639;GO:0006638;GO:0034367;GO:0034368;GO:0034369;GO:0015711;GO:1902652;GO:1901564;GO:0046486;GO:0043691;GO:0010876;GO:0010874;GO:0016192;GO:0044707;GO:0019538;GO:0090077;GO:0048878;GO:0019637;GO:0034375;GO:0034374;GO:0034372;GO:0015918;GO:0034370;GO:0015914;GO:0006807;GO:0050789;GO:0097164;GO:0016043;GO:0065007;GO:1901360;GO:0065008;GO:0006629;GO:0009308;GO:0050793;GO:0006811;GO:0006810;GO:0050794;GO:0008150;GO:0008152;GO:0042632;GO:0051234;GO:0006897;GO:0032368;GO:0006898;GO:0042439;GO:0006576;GO:1901615;GO:0006869;GO:0050801;GO:0030154;GO:0030301;GO:0034641;GO:0044699;GO:0032374;GO:0015850;GO:0032371;GO:0032502;GO:0006644;GO:0032501;GO:0009987;GO:0055088;GO:0045596;GO:0045595;GO:0048519;GO:0055081;GO:0044255;GO:0032879;GO:0008202;GO:0008203;GO:0051093;GO:0043170;GO:0006066;GO:0046470;GO:0042157;GO:0006650;GO:0043933;GO:0042592;GO:0016125;GO:0055092;GO:0055091;GO:0055090;GO:0071825;GO:0071827;GO:0006641;GO:0071704;GO:0033344;GO:0071702;GO:0010745;GO:0010742;GO:0010743;GO:0070328;GO:0006793;GO:0044767;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0044238;GO:0044106;GO:0044237;GO:0006796;GO:0015748;GO:0048523; regulation of transport;anion transport;small molecule metabolic process;triglyceride transport;acylglycerol transport;cellular component organization or biogenesis;single-organism metabolic process;cellular developmental process;regulation of plasma lipoprotein particle levels;macromolecule localization;acylglycerol metabolic process;neutral lipid metabolic process;macromolecular complex remodeling;protein-lipid complex remodeling;plasma lipoprotein particle remodeling;organic anion transport;secondary alcohol metabolic process;organonitrogen compound metabolic process;glycerolipid metabolic process;reverse cholesterol transport;lipid localization;regulation of cholesterol efflux;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;foam cell differentiation;chemical homeostasis;organophosphate metabolic process;high-density lipoprotein particle remodeling;low-density lipoprotein particle remodeling;very-low-density lipoprotein particle remodeling;sterol transport;triglyceride-rich lipoprotein particle remodeling;phospholipid transport;nitrogen compound metabolic process;regulation of biological process;ammonium ion metabolic process;cellular component organization;biological regulation;organic cyclic compound metabolic process;regulation of biological quality;lipid metabolic process;amine metabolic process;regulation of developmental process;ion transport;transport;regulation of cellular process;biological_process;metabolic process;cholesterol homeostasis;establishment of localization;endocytosis;regulation of lipid transport;receptor-mediated endocytosis;ethanolamine-containing compound metabolic process;cellular biogenic amine metabolic process;organic hydroxy compound metabolic process;lipid transport;ion homeostasis;cell differentiation;cholesterol transport;cellular nitrogen compound metabolic process;single-organism process;regulation of cholesterol transport;organic hydroxy compound transport;regulation of sterol transport;developmental process;phospholipid metabolic process;multicellular organismal process;cellular process;lipid homeostasis;negative regulation of cell differentiation;regulation of cell differentiation;negative regulation of biological process;anion homeostasis;cellular lipid metabolic process;regulation of localization;steroid metabolic process;cholesterol metabolic process;negative regulation of developmental process;macromolecule metabolic process;alcohol metabolic process;phosphatidylcholine metabolic process;lipoprotein metabolic process;glycerophospholipid metabolic process;macromolecular complex subunit organization;homeostatic process;sterol metabolic process;sterol homeostasis;phospholipid homeostasis;acylglycerol homeostasis;protein-lipid complex subunit organization;plasma lipoprotein particle organization;triglyceride metabolic process;organic substance metabolic process;cholesterol efflux;organic substance transport;negative regulation of macrophage derived foam cell differentiation;macrophage derived foam cell differentiation;regulation of macrophage derived foam cell differentiation;triglyceride homeostasis;phosphorus metabolic process;single-organism developmental process;single-organism transport;single-organism cellular process;localization;single-organism localization;primary metabolic process;cellular amine metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;organophosphate ester transport;negative regulation of cellular process; 4;6;4;7;6;2;3;4;3;3;6;5;5;6;4;6;6;4;5;8;4;8;5;3;4;6;5;4;5;5;6;6;5;6;3;2;4;3;2;4;3;4;5;3;5;4;3;1;2;8;3;6;5;7;4;6;4;5;6;5;7;4;2;7;5;6;2;5;2;2;6;4;4;2;7;4;3;5;7;3;4;5;5;5;6;4;4;6;7;7;7;5;4;7;3;8;5;5;7;5;8;4;3;4;3;2;3;3;5;3;5;5;3; GO:0034358;GO:0031982;GO:0034364;GO:0043230;GO:0044421;GO:0043227;GO:1990777;GO:0032994;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;vesicle;high-density lipoprotein particle;extracellular organelle;extracellular region part;membrane-bounded organelle;lipoprotein particle;protein-lipid complex;extracellular exosome;organelle;extracellular vesicle;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;4;4;3;2;3;4;3;4;2;3;3;2;1;2; GO:0005548;GO:0005543;GO:0005319;GO:0005496;GO:0015485;GO:0015248;GO:0032934;GO:0003674;GO:0005488;GO:0036094;GO:0022892;GO:0097159;GO:0043168;GO:0043169;GO:0043167;GO:0070405;GO:0005215;GO:0008289;GO:0043178;GO:0017129;GO:0017127;GO:0050997;GO:0031210; phospholipid transporter activity;phospholipid binding;lipid transporter activity;steroid binding;cholesterol binding;sterol transporter activity;sterol binding;molecular_function;binding;small molecule binding;substrate-specific transporter activity;organic cyclic compound binding;anion binding;cation binding;ion binding;ammonium ion binding;transporter activity;lipid binding;alcohol binding;triglyceride binding;cholesterol transporter activity;quaternary ammonium group binding;phosphatidylcholine binding; 5;4;4;4;6;5;5;1;2;3;3;3;4;4;3;5;2;3;4;4;6;3;4; K16835 IPR017954;IPR017943;IPR017942;IPR001124;IPR032942;IPR017130; Lipid-binding serum glycoprotein, conserved site;Bactericidal permeability-increasing protein, alpha/beta domain;Lipid-binding serum glycoprotein, N-terminal;Lipid-binding serum glycoprotein, C-terminal;BPI/LBP/Plunc family;Cholesteryl ester transfer; extracellular Hs4557443 1014.0 V [V] Defense mechanisms; O14791 Apolipoprotein L1 OS=Homo sapiens OX=9606 GN=APOL1 PE=1 SV=5 - [APOL1_HUMAN] 0.981 0.989 1.036 1.058 0.943 1.195 0.991911021 0.773002601 1.12195122 0.009788776 1.04752275 0.075744775 1.267232238 0.001677731 GO:0006820;GO:0006821;GO:0044281;GO:1901360;GO:0044710;GO:0001906;GO:0033036;GO:1902652;GO:0010876;GO:0051704;GO:0065008;GO:0016192;GO:0019538;GO:0002376;GO:0019835;GO:0065007;GO:0098661;GO:0098660;GO:0006629;GO:0006811;GO:0006810;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0051234;GO:0006897;GO:0050896;GO:0006898;GO:0031640;GO:1901615;GO:0006869;GO:0044699;GO:0044364;GO:0016125;GO:0009987;GO:0055085;GO:0008202;GO:0008203;GO:0043170;GO:0042157;GO:0006066;GO:0071704;GO:0071702;GO:0015698;GO:1902476;GO:0045087;GO:0034220;GO:0044765;GO:0044763;GO:0051179;GO:1902578;GO:0044238;GO:0098656;GO:0035821; anion transport;chloride transport;small molecule metabolic process;organic cyclic compound metabolic process;single-organism metabolic process;cell killing;macromolecule localization;secondary alcohol metabolic process;lipid localization;multi-organism process;regulation of biological quality;vesicle-mediated transport;protein metabolic process;immune system process;cytolysis;biological regulation;inorganic anion transmembrane transport;inorganic ion transmembrane transport;lipid metabolic process;ion transport;transport;defense response;response to stress;biological_process;metabolic process;immune response;establishment of localization;endocytosis;response to stimulus;receptor-mediated endocytosis;killing of cells of other organism;organic hydroxy compound metabolic process;lipid transport;single-organism process;disruption of cells of other organism;sterol metabolic process;cellular process;transmembrane transport;steroid metabolic process;cholesterol metabolic process;macromolecule metabolic process;lipoprotein metabolic process;alcohol metabolic process;organic substance metabolic process;organic substance transport;inorganic anion transport;chloride transmembrane transport;innate immune response;ion transmembrane transport;single-organism transport;single-organism cellular process;localization;single-organism localization;primary metabolic process;anion transmembrane transport;modification of morphology or physiology of other organism; 6;8;4;4;3;2;3;6;4;2;3;5;4;2;3;2;7;6;4;5;4;4;3;1;2;3;3;6;2;7;3;4;5;2;4;6;2;4;5;7;4;5;5;3;5;7;8;4;5;4;3;2;3;3;6;3; GO:0034358;GO:0016020;GO:0034361;GO:0034364;GO:0044425;GO:0044421;GO:0072562;GO:0031224;GO:0034385;GO:1990777;GO:0032994;GO:0005615;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;membrane;very-low-density lipoprotein particle;high-density lipoprotein particle;membrane part;extracellular region part;blood microparticle;intrinsic component of membrane;triglyceride-rich lipoprotein particle;lipoprotein particle;protein-lipid complex;extracellular space;macromolecular complex;cellular_component;extracellular region; 3;2;5;4;2;2;3;3;4;4;3;3;2;1;2; GO:0008509;GO:0003674;GO:0005488;GO:0022803;GO:0005253;GO:0005254;GO:0022891;GO:0022892;GO:0015075;GO:0015267;GO:0005215;GO:0005216;GO:0008289;GO:0022838;GO:0015103;GO:0015108;GO:0022857; anion transmembrane transporter activity;molecular_function;binding;passive transmembrane transporter activity;anion channel activity;chloride channel activity;substrate-specific transmembrane transporter activity;substrate-specific transporter activity;ion transmembrane transporter activity;channel activity;transporter activity;ion channel activity;lipid binding;substrate-specific channel activity;inorganic anion transmembrane transporter activity;chloride transmembrane transporter activity;transmembrane transporter activity; 6;1;2;4;7;8;4;3;5;5;2;6;3;5;7;8;3; K23585 IPR008405; Apolipoprotein L; endoplasmic reticulum P37802 Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3 - [TAGL2_HUMAN] 1.022 1.097 0.851 1.158 0.907 1.675 0.931631723 0.292342111 1.276736494 0.141300843 0.775752051 0.177097176 1.846747519 0.174259124 GO:0032502;GO:0030154;GO:0048869;GO:0060429;GO:0009888;GO:0044767;GO:0008150;GO:0030855;GO:0044763;GO:0009987;GO:0044699;GO:0048856; developmental process;cell differentiation;cellular developmental process;epithelium development;tissue development;single-organism developmental process;biological_process;epithelial cell differentiation;single-organism cellular process;cellular process;single-organism process;anatomical structure development; 2;5;4;5;4;3;1;6;3;2;2;3; GO:0005575;GO:0031982;GO:0043230;GO:0070062;GO:0044421;GO:0005576;GO:1903561;GO:0043227;GO:0043226; cellular_component;vesicle;extracellular organelle;extracellular exosome;extracellular region part;extracellular region;extracellular vesicle;membrane-bounded organelle;organelle; 1;4;3;4;2;2;3;3;2; K20526 IPR001715;IPR001061;IPR000557;IPR003096; Calponin homology domain;Transgelin-2;Calponin repeat;Smooth muscle protein/calponin; cytosol, nucleus Hs4507357 413.0 Z [Z] Cytoskeleton; Q8NBJ4 Golgi membrane protein 1 OS=Homo sapiens OX=9606 GN=GOLM1 PE=1 SV=1 - [GOLM1_HUMAN] 0.952 1.212 0.884 1.152 0.96 1.34 0.785478548 nan 1.2 nan 0.729372937 nan 1.395833333 nan GO:0080090;GO:0019222;GO:0071840;GO:0044710;GO:0019216;GO:0016043;GO:0050789;GO:0071704;GO:0065007;GO:0044699;GO:0006629;GO:0044238;GO:0009987;GO:0008150;GO:0008152;GO:0006996;GO:0006997; regulation of primary metabolic process;regulation of metabolic process;cellular component organization or biogenesis;single-organism metabolic process;regulation of lipid metabolic process;cellular component organization;regulation of biological process;organic substance metabolic process;biological regulation;single-organism process;lipid metabolic process;primary metabolic process;cellular process;biological_process;metabolic process;organelle organization;nucleus organization; 4;3;2;3;5;3;2;3;2;2;4;3;2;1;2;4;5; GO:0016020;GO:0031224;GO:0043229;GO:0071944;GO:0005887;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0005615;GO:0031226;GO:0016021;GO:0044459;GO:0005794;GO:0012505;GO:0005886;GO:1903561;GO:0031982;GO:0043230;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044425;GO:0044421; membrane;intrinsic component of membrane;intracellular organelle;cell periphery;integral component of plasma membrane;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;extracellular space;intrinsic component of plasma membrane;integral component of membrane;plasma membrane part;Golgi apparatus;endomembrane system;plasma membrane;extracellular vesicle;vesicle;extracellular organelle;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;membrane part;extracellular region part; 2;3;3;3;4;3;2;4;4;3;4;4;3;4;3;3;3;4;3;4;2;2;3;1;4;2;3;2;2; IPR026143;IPR026139; Golgi membrane protein 1;GOLM1/CASC4 family; extracellular P04196 Histidine-rich glycoprotein OS=Homo sapiens OX=9606 GN=HRG PE=1 SV=1 - [HRG_HUMAN] 1.075 1.013 0.872 1.032 1.077 1.1 1.061204344 0.000556059 0.95821727 0.005529005 0.860809477 0.001092402 1.021355617 1.20E-05 GO:0007599;GO:0007596;GO:0051716;GO:0043207;GO:0018212;GO:0033043;GO:0050832;GO:0042325;GO:0009607;GO:0010631;GO:0009605;GO:0010633;GO:0019538;GO:0060491;GO:0009892;GO:0050778;GO:1901342;GO:1901343;GO:1903391;GO:1903393;GO:0050789;GO:0051346;GO:0006887;GO:0002684;GO:0002682;GO:0043412;GO:0032956;GO:0001974;GO:0036211;GO:0044085;GO:0051493;GO:0051129;GO:0051128;GO:2000181;GO:0038084;GO:0002418;GO:0010632;GO:0008285;GO:0050878;GO:0008283;GO:0001558;GO:0098542;GO:0030036;GO:0045216;GO:0034329;GO:0016525;GO:0045926;GO:0030030;GO:0030031;GO:0030032;GO:0018108;GO:0061041;GO:0061045;GO:0008219;GO:0007275;GO:0043065;GO:0043067;GO:0043068;GO:0006468;GO:0006461;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0010951;GO:0010591;GO:0051271;GO:0040012;GO:0010594;GO:0010596;GO:0048856;GO:0006796;GO:2000026;GO:0006793;GO:0048523;GO:0048522;GO:1901890;GO:0048771;GO:0007160;GO:0007162;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0031345;GO:0031344;GO:0045785;GO:0070848;GO:0044092;GO:0006935;GO:0051707;GO:0010033;GO:2001027;GO:2001026;GO:1901678;GO:0002839;GO:0002834;GO:0002837;GO:0002836;GO:0002831;GO:0002833;GO:0050820;GO:0044267;GO:0010646;GO:0051181;GO:0001568;GO:0035767;GO:0050793;GO:0050790;GO:0090287;GO:0050794;GO:0051239;GO:0051234;GO:0051336;GO:0050896;GO:2000145;GO:2000146;GO:0032102;GO:0032103;GO:0032101;GO:0001944;GO:0007045;GO:0007044;GO:0070887;GO:0044699;GO:0051248;GO:0002347;GO:0051240;GO:0051241;GO:0051246;GO:0090288;GO:0031399;GO:1903034;GO:1903035;GO:1903036;GO:0040011;GO:0040013;GO:0051270;GO:0090132;GO:0090130;GO:0048731;GO:0043933;GO:0034332;GO:0034330;GO:0048041;GO:0001525;GO:0042981;GO:0033628;GO:0033629;GO:0033627;GO:0030029;GO:0052547;GO:0052548;GO:0010811;GO:0042221;GO:0006996;GO:0044238;GO:0009620;GO:0044237;GO:0019220;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0072359;GO:0072358;GO:0060326;GO:0090109;GO:0071840;GO:0009968;GO:0048514;GO:0048518;GO:0048519;GO:0042127;GO:0031589;GO:1901888;GO:0043537;GO:0043535;GO:0043534;GO:0044700;GO:0016192;GO:0044707;GO:0050730;GO:0002376;GO:0035924;GO:0022607;GO:0022603;GO:1902547;GO:0006928;GO:0051674;GO:0043542;GO:0045055;GO:1900046;GO:1900047;GO:0032970;GO:0016477;GO:1900048;GO:0048646;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:0050817;GO:0006955;GO:0010605;GO:0050818;GO:0050819;GO:0046903;GO:0080134;GO:0001775;GO:1900747;GO:1900746;GO:0030155;GO:0050865;GO:0006508;GO:0051918;GO:0032502;GO:0032501;GO:0009987;GO:0032879;GO:0050776;GO:0071363;GO:0015886;GO:0001954;GO:0001952;GO:2000504;GO:0002576;GO:0045765;GO:0071705;GO:0071704;GO:0071310;GO:0071702;GO:0030336;GO:0030334;GO:0006915;GO:0051174;GO:0097581;GO:0051179;GO:1902578;GO:0009966;GO:1902589;GO:0080090;GO:0050920;GO:0050922;GO:0051893;GO:0051894;GO:0042330;GO:0009611;GO:0018193;GO:0051704;GO:0060255;GO:0030162;GO:0060312;GO:0030168;GO:0048870;GO:0030193;GO:0030195;GO:0030194;GO:0032940;GO:0016049;GO:0016043;GO:0070271;GO:0065003;GO:0010810;GO:0065007;GO:0010543;GO:0065009;GO:0065008;GO:0051130;GO:0042060;GO:0008150;GO:0008152;GO:0043254;GO:0042730;GO:0030308;GO:0016310;GO:0023057;GO:0023052;GO:0010648;GO:0023051;GO:0001667;GO:0009653;GO:0043086;GO:0051917;GO:0022610;GO:0051093;GO:0032269;GO:0032268;GO:0043170;GO:0045861;GO:0031324;GO:0031323;GO:0010593;GO:0090303;GO:0010942;GO:0010941;GO:0040007;GO:0071822;GO:0040008;GO:0010467;GO:0010466;GO:1902548;GO:0010468;GO:0034103;GO:0034105;GO:0034333;GO:0007155;GO:0007154;GO:0007010;GO:0044260;GO:0044087;GO:1902744;GO:0001932;GO:1902743;GO:0044089; hemostasis;blood coagulation;cellular response to stimulus;response to external biotic stimulus;peptidyl-tyrosine modification;regulation of organelle organization;defense response to fungus;regulation of phosphorylation;response to biotic stimulus;epithelial cell migration;response to external stimulus;negative regulation of epithelial cell migration;protein metabolic process;regulation of cell projection assembly;negative regulation of metabolic process;positive regulation of immune response;regulation of vasculature development;negative regulation of vasculature development;regulation of adherens junction organization;positive regulation of adherens junction organization;regulation of biological process;negative regulation of hydrolase activity;exocytosis;positive regulation of immune system process;regulation of immune system process;macromolecule modification;regulation of actin cytoskeleton organization;blood vessel remodeling;protein modification process;cellular component biogenesis;regulation of cytoskeleton organization;negative regulation of cellular component organization;regulation of cellular component organization;negative regulation of blood vessel morphogenesis;vascular endothelial growth factor signaling pathway;immune response to tumor cell;regulation of epithelial cell migration;negative regulation of cell proliferation;regulation of body fluid levels;cell proliferation;regulation of cell growth;defense response to other organism;actin cytoskeleton organization;cell-cell junction organization;cell junction assembly;negative regulation of angiogenesis;negative regulation of growth;cell projection organization;cell projection assembly;lamellipodium assembly;peptidyl-tyrosine phosphorylation;regulation of wound healing;negative regulation of wound healing;cell death;multicellular organism development;positive regulation of apoptotic process;regulation of programmed cell death;positive regulation of programmed cell death;protein phosphorylation;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;negative regulation of endopeptidase activity;regulation of lamellipodium assembly;negative regulation of cellular component movement;regulation of locomotion;regulation of endothelial cell migration;negative regulation of endothelial cell migration;anatomical structure development;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of cellular process;positive regulation of cellular process;positive regulation of cell junction assembly;tissue remodeling;cell-matrix adhesion;negative regulation of cell adhesion;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;negative regulation of cell projection organization;regulation of cell projection organization;positive regulation of cell adhesion;response to growth factor;negative regulation of molecular function;chemotaxis;response to other organism;response to organic substance;negative regulation of endothelial cell chemotaxis;regulation of endothelial cell chemotaxis;iron coordination entity transport;positive regulation of immune response to tumor cell;regulation of response to tumor cell;regulation of immune response to tumor cell;positive regulation of response to tumor cell;regulation of response to biotic stimulus;positive regulation of response to biotic stimulus;positive regulation of coagulation;cellular protein metabolic process;regulation of cell communication;cofactor transport;blood vessel development;endothelial cell chemotaxis;regulation of developmental process;regulation of catalytic activity;regulation of cellular response to growth factor stimulus;regulation of cellular process;regulation of multicellular organismal process;establishment of localization;regulation of hydrolase activity;response to stimulus;regulation of cell motility;negative regulation of cell motility;negative regulation of response to external stimulus;positive regulation of response to external stimulus;regulation of response to external stimulus;vasculature development;cell-substrate adherens junction assembly;cell-substrate junction assembly;cellular response to chemical stimulus;single-organism process;negative regulation of protein metabolic process;response to tumor cell;positive regulation of multicellular organismal process;negative regulation of multicellular organismal process;regulation of protein metabolic process;negative regulation of cellular response to growth factor stimulus;regulation of protein modification process;regulation of response to wounding;negative regulation of response to wounding;positive regulation of response to wounding;locomotion;negative regulation of locomotion;regulation of cellular component movement;epithelium migration;tissue migration;system development;macromolecular complex subunit organization;adherens junction organization;cell junction organization;focal adhesion assembly;angiogenesis;regulation of apoptotic process;regulation of cell adhesion mediated by integrin;negative regulation of cell adhesion mediated by integrin;cell adhesion mediated by integrin;actin filament-based process;regulation of peptidase activity;regulation of endopeptidase activity;positive regulation of cell-substrate adhesion;response to chemical;organelle organization;primary metabolic process;response to fungus;cellular metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;circulatory system development;cardiovascular system development;cell chemotaxis;regulation of cell-substrate junction assembly;cellular component organization or biogenesis;negative regulation of signal transduction;blood vessel morphogenesis;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;cell-substrate adhesion;regulation of cell junction assembly;negative regulation of blood vessel endothelial cell migration;regulation of blood vessel endothelial cell migration;blood vessel endothelial cell migration;single organism signaling;vesicle-mediated transport;single-multicellular organism process;regulation of peptidyl-tyrosine phosphorylation;immune system process;cellular response to vascular endothelial growth factor stimulus;cellular component assembly;regulation of anatomical structure morphogenesis;regulation of cellular response to vascular endothelial growth factor stimulus;movement of cell or subcellular component;localization of cell;endothelial cell migration;regulated exocytosis;regulation of hemostasis;negative regulation of hemostasis;regulation of actin filament-based process;cell migration;positive regulation of hemostasis;anatomical structure formation involved in morphogenesis;transport;defense response;programmed cell death;response to stress;coagulation;immune response;negative regulation of macromolecule metabolic process;regulation of coagulation;negative regulation of coagulation;secretion;regulation of response to stress;cell activation;negative regulation of vascular endothelial growth factor signaling pathway;regulation of vascular endothelial growth factor signaling pathway;regulation of cell adhesion;regulation of cell activation;proteolysis;negative regulation of fibrinolysis;developmental process;multicellular organismal process;cellular process;regulation of localization;regulation of immune response;cellular response to growth factor stimulus;heme transport;positive regulation of cell-matrix adhesion;regulation of cell-matrix adhesion;positive regulation of blood vessel remodeling;platelet degranulation;regulation of angiogenesis;nitrogen compound transport;organic substance metabolic process;cellular response to organic substance;organic substance transport;negative regulation of cell migration;regulation of cell migration;apoptotic process;regulation of phosphorus metabolic process;lamellipodium organization;localization;single-organism localization;regulation of signal transduction;single-organism organelle organization;regulation of primary metabolic process;regulation of chemotaxis;negative regulation of chemotaxis;regulation of focal adhesion assembly;positive regulation of focal adhesion assembly;taxis;response to wounding;peptidyl-amino acid modification;multi-organism process;regulation of macromolecule metabolic process;regulation of proteolysis;regulation of blood vessel remodeling;platelet activation;cell motility;regulation of blood coagulation;negative regulation of blood coagulation;positive regulation of blood coagulation;secretion by cell;cell growth;cellular component organization;protein complex biogenesis;macromolecular complex assembly;regulation of cell-substrate adhesion;biological regulation;regulation of platelet activation;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;wound healing;biological_process;metabolic process;regulation of protein complex assembly;fibrinolysis;negative regulation of cell growth;phosphorylation;negative regulation of signaling;signaling;negative regulation of cell communication;regulation of signaling;ameboidal-type cell migration;anatomical structure morphogenesis;negative regulation of catalytic activity;regulation of fibrinolysis;biological adhesion;negative regulation of developmental process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;macromolecule metabolic process;negative regulation of proteolysis;negative regulation of cellular metabolic process;regulation of cellular metabolic process;negative regulation of lamellipodium assembly;positive regulation of wound healing;positive regulation of cell death;regulation of cell death;growth;protein complex subunit organization;regulation of growth;gene expression;negative regulation of peptidase activity;negative regulation of cellular response to vascular endothelial growth factor stimulus;regulation of gene expression;regulation of tissue remodeling;positive regulation of tissue remodeling;adherens junction assembly;cell adhesion;cell communication;cytoskeleton organization;cellular macromolecule metabolic process;regulation of cellular component biogenesis;negative regulation of lamellipodium organization;regulation of protein phosphorylation;regulation of lamellipodium organization;positive regulation of cellular component biogenesis; 5;5;3;4;8;5;5;7;3;6;3;4;4;4;3;4;5;4;5;5;2;6;5;3;3;5;5;5;5;3;6;4;4;5;8;4;4;4;4;3;4;4;5;5;5;5;3;4;5;6;8;6;5;4;4;6;5;5;7;5;6;3;4;3;8;5;4;3;5;5;3;5;4;4;3;3;4;4;5;4;4;5;6;7;5;5;4;5;4;4;3;4;5;5;5;5;5;5;5;4;4;4;5;4;5;4;6;3;4;4;3;3;3;5;2;4;4;4;4;4;5;7;6;4;2;5;4;3;3;5;4;6;5;4;4;2;3;4;5;4;4;4;6;4;6;4;6;5;5;4;4;6;7;5;3;4;3;4;3;6;3;3;3;3;5;5;5;5;2;4;4;2;2;4;4;4;6;6;8;3;5;3;8;2;7;4;4;5;4;3;7;6;4;4;4;4;4;3;4;4;5;3;4;3;4;4;4;5;4;4;5;5;4;4;5;3;2;2;2;3;4;6;6;6;6;5;7;5;5;3;5;5;5;5;6;5;5;2;3;4;4;4;4;4;6;5;3;4;7;2;4;6;5;5;3;5;5;5;4;3;3;4;5;5;2;5;3;3;4;5;1;2;4;6;4;6;3;2;4;3;5;3;5;6;2;3;5;5;4;6;4;4;6;5;4;4;2;5;3;5;7;5;5;4;4;6;3;4;5;4;3;6;7;6;3; GO:0034774;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0071944;GO:0005615;GO:0070062;GO:0005764;GO:0005768;GO:0016023;GO:0016020;GO:0099503;GO:0043230;GO:0043231;GO:0043233;GO:0072562;GO:0044433;GO:0030141;GO:0060205;GO:0031091;GO:0031093;GO:0036019;GO:0031974;GO:0005773;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0044446;GO:0044444;GO:0000323;GO:0031983;GO:0031982;GO:0031988;GO:0005737;GO:0097708;GO:0031410;GO:0005623;GO:0005886;GO:1903561;GO:0005575;GO:0005576; secretory granule lumen;intracellular part;extracellular region part;organelle part;cell part;cell periphery;extracellular space;extracellular exosome;lysosome;endosome;cytoplasmic, membrane-bounded vesicle;membrane;secretory vesicle;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;blood microparticle;cytoplasmic vesicle part;secretory granule;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;platelet alpha granule lumen;endolysosome;membrane-enclosed lumen;vacuole;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;intracellular organelle part;cytoplasmic part;lytic vacuole;vesicle lumen;vesicle;membrane-bounded vesicle;cytoplasm;intracellular vesicle;cytoplasmic vesicle;cell;plasma membrane;extracellular vesicle;cellular_component;extracellular region; 5;3;2;2;2;3;3;4;7;4;5;2;6;3;4;3;3;4;4;5;5;6;5;2;5;3;3;3;2;3;3;4;6;4;4;5;4;4;5;2;3;3;1;2; GO:0098772;GO:0005488;GO:1901681;GO:0019865;GO:0046914;GO:0020037;GO:0004857;GO:0001948;GO:0032403;GO:0005515;GO:0005102;GO:0061135;GO:0061134;GO:1901363;GO:0046872;GO:0003674;GO:0046906;GO:0097159;GO:0043168;GO:0043169;GO:0043167;GO:0004866;GO:0004867;GO:0004869;GO:0030234;GO:0008270;GO:0044877;GO:0097367;GO:0043395;GO:0043394;GO:0005539;GO:0030414;GO:0008201; molecular function regulator;binding;sulfur compound binding;immunoglobulin binding;transition metal ion binding;heme binding;enzyme inhibitor activity;glycoprotein binding;protein complex binding;protein binding;receptor binding;endopeptidase regulator activity;peptidase regulator activity;heterocyclic compound binding;metal ion binding;molecular_function;tetrapyrrole binding;organic cyclic compound binding;anion binding;cation binding;ion binding;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;cysteine-type endopeptidase inhibitor activity;enzyme regulator activity;zinc ion binding;macromolecular complex binding;carbohydrate derivative binding;heparan sulfate proteoglycan binding;proteoglycan binding;glycosaminoglycan binding;peptidase inhibitor activity;heparin binding; 2;2;3;5;6;5;4;4;4;3;4;5;4;3;5;1;4;3;4;4;3;6;7;7;3;7;3;3;4;5;4;5;4; K23410 IPR000010; Cystatin domain; extracellular P23280 Carbonic anhydrase 6 OS=Homo sapiens OX=9606 GN=CA6 PE=1 SV=3 - [CAH6_HUMAN] 0.883 1.171 1.147 0.707 1.294 0.704 0.754056362 0.016764653 0.546367852 0.009436117 0.979504697 0.538536023 0.544049459 0.007136299 GO:0015701;GO:0009593;GO:0044237;GO:0006730;GO:0006820;GO:0050906;GO:0050907;GO:0042221;GO:0050909;GO:0044699;GO:0044710;GO:0051234;GO:0001580;GO:0007606;GO:0071702;GO:0003008;GO:0044281;GO:0032501;GO:0050877;GO:0006811;GO:0006810;GO:0015711;GO:0007600;GO:0044765;GO:0050912;GO:0008150;GO:0008152;GO:0051606;GO:0051179;GO:1902578;GO:0050896;GO:0050913;GO:0044763;GO:0009987; bicarbonate transport;detection of chemical stimulus;cellular metabolic process;one-carbon metabolic process;anion transport;detection of stimulus involved in sensory perception;detection of chemical stimulus involved in sensory perception;response to chemical;sensory perception of taste;single-organism process;single-organism metabolic process;establishment of localization;detection of chemical stimulus involved in sensory perception of bitter taste;sensory perception of chemical stimulus;organic substance transport;system process;small molecule metabolic process;multicellular organismal process;neurological system process;ion transport;transport;organic anion transport;sensory perception;single-organism transport;detection of chemical stimulus involved in sensory perception of taste;biological_process;metabolic process;detection of stimulus;localization;single-organism localization;response to stimulus;sensory perception of bitter taste;single-organism cellular process;cellular process; 7;4;3;4;6;4;5;3;7;2;3;3;7;6;5;3;4;2;4;5;4;6;5;4;6;1;2;3;2;3;2;8;3;2; GO:0005829;GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0005615;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0005576;GO:0044424;GO:0044421; cytosol;membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;extracellular space;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;extracellular region;intracellular part;extracellular region part; 5;3;2;4;4;3;3;4;3;2;2;3;1;4;2;3;2; GO:0016836;GO:0004089;GO:0043169;GO:0046914;GO:0016829;GO:0008270;GO:0043167;GO:0003824;GO:0046872;GO:0016835;GO:0003674;GO:0005488; hydro-lyase activity;carbonate dehydratase activity;cation binding;transition metal ion binding;lyase activity;zinc ion binding;ion binding;catalytic activity;metal ion binding;carbon-oxygen lyase activity;molecular_function;binding; 5;6;4;6;3;7;3;2;5;4;1;2; K01672 map00910; Nitrogen metabolism; IPR018338;IPR023561;IPR001148;IPR018428; Carbonic anhydrase, alpha-class, conserved site;Carbonic anhydrase, alpha-class;Alpha carbonic anhydrase;Carbonic anhydrase, CA-VI; extracellular Hs4557397 639.0 R [R] General function prediction only; P29622 Kallistatin OS=Homo sapiens OX=9606 GN=SERPINA4 PE=1 SV=3 - [KAIN_HUMAN] 1.023 1.062 0.942 0.963 1.178 0.872 0.963276836 0.061039399 0.817487267 2.17E-12 0.88700565 0.008925849 0.740237691 0.254909098 GO:0009892;GO:0080090;GO:0019222;GO:0031324;GO:0031323;GO:0050789;GO:0044267;GO:0051248;GO:0010605;GO:0051346;GO:0044260;GO:0051246;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0050790;GO:0052547;GO:0052548;GO:0009987;GO:0050794;GO:0008150;GO:0008152;GO:0006508;GO:0010951;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0060255;GO:0044237;GO:0043170;GO:0019538;GO:0030162;GO:0045861;GO:0048523; negative regulation of metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of biological process;cellular protein metabolic process;negative regulation of protein metabolic process;negative regulation of macromolecule metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;regulation of protein metabolic process;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;regulation of catalytic activity;regulation of peptidase activity;regulation of endopeptidase activity;cellular process;regulation of cellular process;biological_process;metabolic process;proteolysis;negative regulation of endopeptidase activity;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;regulation of macromolecule metabolic process;cellular metabolic process;macromolecule metabolic process;protein metabolic process;regulation of proteolysis;negative regulation of proteolysis;negative regulation of cellular process; 3;4;3;4;4;2;5;5;4;6;4;5;5;3;7;2;4;2;3;4;6;7;2;3;1;2;5;8;5;3;5;5;4;3;4;4;6;6;3; GO:0043226;GO:0043227;GO:0005615;GO:0031982;GO:1903561;GO:0070062;GO:0043230;GO:0005575;GO:0005576;GO:0044421; organelle;membrane-bounded organelle;extracellular space;vesicle;extracellular vesicle;extracellular exosome;extracellular organelle;cellular_component;extracellular region;extracellular region part; 2;3;3;4;3;4;3;1;2;2; GO:0030414;GO:0003674;GO:0004857;GO:0098772;GO:0061134;GO:0061135;GO:0004866;GO:0030234;GO:0004867; peptidase inhibitor activity;molecular_function;enzyme inhibitor activity;molecular function regulator;peptidase regulator activity;endopeptidase regulator activity;endopeptidase inhibitor activity;enzyme regulator activity;serine-type endopeptidase inhibitor activity; 5;1;4;2;4;5;6;3;7; K04525 IPR023795;IPR000215;IPR023796; Serpin, conserved site;Serpin family;Serpin domain; plasma membrane Hs21361302 883.0 V [V] Defense mechanisms; Q9H756 Leucine-rich repeat-containing protein 19 OS=Homo sapiens OX=9606 GN=LRRC19 PE=2 SV=1 - [LRC19_HUMAN] 0.878 1.006 1.245 0.848 0.932 1.74 0.872763419 nan 0.909871245 nan 1.237574553 nan 1.86695279 nan GO:0051348;GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0007165;GO:0007166;GO:0019221;GO:0051716;GO:0010605;GO:0009968;GO:0009966;GO:0044092;GO:0048519;GO:0060255;GO:0045859;GO:0010033;GO:0042325;GO:0044700;GO:0042326;GO:0019538;GO:0007154;GO:0033673;GO:0009892;GO:0035556;GO:0050789;GO:0044267;GO:0044260;GO:0043549;GO:0065007;GO:0065009;GO:0034097;GO:0050790;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:1902532;GO:1902531;GO:0071345;GO:0031400;GO:0051338;GO:0016310;GO:0023057;GO:0023052;GO:0010648;GO:0070887;GO:0023051;GO:0010646;GO:0043086;GO:0044699;GO:0051248;GO:0010563;GO:0051246;GO:0007259;GO:0031399;GO:0009987;GO:0032269;GO:0032268;GO:0043170;GO:1904893;GO:1904892;GO:0050896;GO:0031324;GO:0031323;GO:0071704;GO:0071310;GO:0097696;GO:0045936;GO:0006468;GO:0006469;GO:0046426;GO:0046425;GO:0006464;GO:0051174;GO:0044763;GO:0042221;GO:0044238;GO:0044237;GO:0006796;GO:0006793;GO:0001933;GO:0001932;GO:0048523; negative regulation of transferase activity;regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;signal transduction;cell surface receptor signaling pathway;cytokine-mediated signaling pathway;cellular response to stimulus;negative regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;negative regulation of molecular function;negative regulation of biological process;regulation of macromolecule metabolic process;regulation of protein kinase activity;response to organic substance;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;protein metabolic process;cell communication;negative regulation of kinase activity;negative regulation of metabolic process;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;regulation of kinase activity;biological regulation;regulation of molecular function;response to cytokine;regulation of catalytic activity;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;negative regulation of intracellular signal transduction;regulation of intracellular signal transduction;cellular response to cytokine stimulus;negative regulation of protein modification process;regulation of transferase activity;phosphorylation;negative regulation of signaling;signaling;negative regulation of cell communication;cellular response to chemical stimulus;regulation of signaling;regulation of cell communication;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;JAK-STAT cascade;regulation of protein modification process;cellular process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;macromolecule metabolic process;negative regulation of STAT cascade;regulation of STAT cascade;response to stimulus;negative regulation of cellular metabolic process;regulation of cellular metabolic process;organic substance metabolic process;cellular response to organic substance;STAT cascade;negative regulation of phosphate metabolic process;protein phosphorylation;negative regulation of protein kinase activity;negative regulation of JAK-STAT cascade;regulation of JAK-STAT cascade;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;response to chemical;primary metabolic process;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of cellular process; 6;6;4;3;3;3;4;5;6;3;4;4;4;4;2;4;7;4;7;3;7;4;4;7;3;5;2;5;4;6;2;3;5;4;3;5;5;1;2;5;5;6;6;5;6;3;2;4;4;3;4;5;2;5;5;5;7;6;2;5;5;4;6;6;2;4;4;3;5;6;6;7;8;7;7;6;5;3;3;3;3;5;4;7;7;3; GO:0016021;GO:0016020;GO:0044424;GO:0044425;GO:0005622;GO:0031224;GO:0005737;GO:0044464;GO:0005623;GO:0005575; integral component of membrane;membrane;intracellular part;membrane part;intracellular;intrinsic component of membrane;cytoplasm;cell part;cell;cellular_component; 4;2;3;2;3;3;4;2;2;1; GO:0098772;GO:0003674;GO:0019887;GO:0004857;GO:0004860;GO:0019207;GO:0019210;GO:0030234; molecular function regulator;molecular_function;protein kinase regulator activity;enzyme inhibitor activity;protein kinase inhibitor activity;kinase regulator activity;kinase inhibitor activity;enzyme regulator activity; 2;1;5;4;6;4;5;3; IPR003591;IPR032675;IPR000483;IPR001611; Leucine-rich repeat, typical subtype;Leucine-rich repeat domain, L domain-like;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat; plasma membrane Hs12597641 749.0 R [R] General function prediction only; P10909 Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1 - [CLUS_HUMAN] 0.996 0.989 1.027 1.047 0.972 1.139 1.007077856 0.37469892 1.077160494 8.32E-11 1.038422649 1.12E-10 1.1718107 7.69E-10 GO:0007599;GO:0007596;GO:0090083;GO:0051716;GO:0032434;GO:0043207;GO:0048583;GO:0045859;GO:0035270;GO:0008366;GO:0065009;GO:0046483;GO:0042325;GO:0042327;GO:0009607;GO:0009605;GO:0019538;GO:0042698;GO:0051788;GO:0009896;GO:0009894;GO:0009892;GO:0009893;GO:0009891;GO:0090261;GO:0051254;GO:0031175;GO:0035556;GO:0050789;GO:0042552;GO:0000902;GO:0006887;GO:0050793;GO:0002684;GO:0002682;GO:1901360;GO:0018130;GO:2000379;GO:0006629;GO:0048709;GO:2000377;GO:0043412;GO:0000003;GO:0016070;GO:0035864;GO:0010557;GO:0048812;GO:0009967;GO:0044802;GO:0044085;GO:0034250;GO:0051129;GO:0051128;GO:0042176;GO:0009416;GO:0010001;GO:0050435;GO:0001774;GO:0032446;GO:0009653;GO:1904407;GO:0008284;GO:0050878;GO:0008283;GO:0006974;GO:0023041;GO:0044257;GO:0032286;GO:0030030;GO:0097190;GO:0097193;GO:0051338;GO:0061517;GO:0061518;GO:0008219;GO:0046209;GO:0043632;GO:2000112;GO:0007275;GO:0043065;GO:0043067;GO:0043066;GO:0060548;GO:0043069;GO:0043068;GO:0006468;GO:0019219;GO:0045087;GO:0006461;GO:0006464;GO:0044767;GO:0044765;GO:0044763;GO:0048858;GO:0048856;GO:0001836;GO:0006796;GO:0006793;GO:0032459;GO:0023057;GO:0048523;GO:0048522;GO:0008104;GO:0007009;GO:0007165;GO:0002455;GO:2000058;GO:0007005;GO:0070661;GO:0044710;GO:0070841;GO:0010256;GO:0070848;GO:0044093;GO:0033036;GO:1902229;GO:0034205;GO:0010038;GO:2001141;GO:2001021;GO:2001020;GO:0051707;GO:0010033;GO:0051704;GO:0044248;GO:0016567;GO:0015918;GO:0015850;GO:0050821;GO:0045321;GO:0006807;GO:0006809;GO:0044267;GO:0044265;GO:0044260;GO:0070997;GO:0097242;GO:0032760;GO:1903409;GO:0050790;GO:0009889;GO:0050794;GO:0051239;GO:1901216;GO:1901214;GO:0051234;GO:0061077;GO:0050896;GO:0010498;GO:2000060;GO:0006511;GO:0006518;GO:0010562;GO:0070271;GO:0009314;GO:0070887;GO:0006457;GO:0044699;GO:0051248;GO:0016064;GO:0051240;GO:0051246;GO:0051247;GO:0051179;GO:0031398;GO:0031399;GO:0031396;GO:2001244;GO:2001243;GO:2001242;GO:0048609;GO:0051347;GO:0010556;GO:0034249;GO:0034248;GO:0002460;GO:1902680;GO:0048731;GO:0043933;GO:0034622;GO:0042981;GO:0042787;GO:1903364;GO:0045935;GO:0030182;GO:0061136;GO:0022414;GO:0072593;GO:0042221;GO:0022008;GO:0043623;GO:0006996;GO:0044238;GO:0044237;GO:2001234;GO:2001235;GO:0032436;GO:0019222;GO:2001233;GO:0048585;GO:0048584;GO:0048468;GO:1901362;GO:0071840;GO:0009968;GO:0009966;GO:0048869;GO:0048511;GO:0048513;GO:1902949;GO:0048518;GO:0048519;GO:0042127;GO:0051091;GO:0045184;GO:0051090;GO:0044700;GO:0044702;GO:1901564;GO:0016192;GO:0044707;GO:0022010;GO:0002274;GO:0002376;GO:1902947;GO:0033554;GO:1902004;GO:1902003;GO:0022607;GO:0033674;GO:1902230;GO:0042987;GO:0097659;GO:0042982;GO:0043549;GO:0045055;GO:0006810;GO:0006952;GO:0012501;GO:0006950;GO:1902430;GO:0006956;GO:0006955;GO:1902532;GO:1902533;GO:0006958;GO:1902531;GO:0051603;GO:0046903;GO:0044271;GO:0080134;GO:0080135;GO:0001775;GO:0006355;GO:0050817;GO:0006351;GO:0031018;GO:0031016;GO:1902991;GO:0045429;GO:1902993;GO:1902996;GO:1902998;GO:0006139;GO:0006959;GO:0043161;GO:1903320;GO:1903322;GO:0032270;GO:0006508;GO:0032502;GO:0032501;GO:0032504;GO:1903052;GO:0031331;GO:1903050;GO:0009987;GO:0019941;GO:1903506;GO:0051259;GO:0050776;GO:0071363;GO:0051252;GO:0050778;GO:0009059;GO:0001816;GO:0001817;GO:0035966;GO:0001819;GO:0031401;GO:0019724;GO:0042116;GO:2001057;GO:0045937;GO:0019220;GO:0010468;GO:0002576;GO:0032989;GO:0071704;GO:0071310;GO:0071706;GO:0071702;GO:0006915;GO:0051174;GO:0009058;GO:0044849;GO:0051171;GO:0051172;GO:0051173;GO:0009056;GO:0009057;GO:1902578;GO:0043217;GO:0072376;GO:0034654;GO:0009628;GO:0080090;GO:0061024;GO:0032774;GO:0010035;GO:0010605;GO:0010604;GO:0009615;GO:0070647;GO:0009611;GO:0030154;GO:0060255;GO:0030162;GO:0030163;GO:0010876;GO:0030168;GO:1902992;GO:1903426;GO:0045428;GO:0019438;GO:0032640;GO:0021782;GO:0032940;GO:1903557;GO:1903555;GO:0007272;GO:1901576;GO:1901575;GO:1903362;GO:0016043;GO:0065003;GO:0065007;GO:1901800;GO:0065008;GO:0051130;GO:0051131;GO:0042063;GO:0042060;GO:0014009;GO:0036211;GO:0008150;GO:0008152;GO:0014003;GO:0043254;GO:0031647;GO:0045732;GO:1902847;GO:0006869;GO:0016310;GO:0030301;GO:0023056;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0010647;GO:0010646;GO:0043085;GO:0007417;GO:1900221;GO:0032291;GO:0017038;GO:0045597;GO:0045595;GO:0045893;GO:1902988;GO:0051092;GO:0008637;GO:0032268;GO:0007568;GO:0008630;GO:0043603;GO:0051094;GO:0043170;GO:0010628;GO:0045862;GO:0045860;GO:0043691;GO:0031329;GO:0031328;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0090304;GO:0010942;GO:0010941;GO:0071822;GO:0044087;GO:0051260;GO:1903508;GO:0010467;GO:1903428;GO:0032460;GO:0032463;GO:0032462;GO:0048666;GO:0031333;GO:0006725;GO:0002449;GO:0007154;GO:0002443;GO:0048699;GO:0032990;GO:0007399;GO:0032680;GO:0002250;GO:0002253;GO:0002252;GO:0015031;GO:0001932;GO:0001934;GO:0044089; hemostasis;blood coagulation;regulation of inclusion body assembly;cellular response to stimulus;regulation of proteasomal ubiquitin-dependent protein catabolic process;response to external biotic stimulus;regulation of response to stimulus;regulation of protein kinase activity;endocrine system development;axon ensheathment;regulation of molecular function;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to biotic stimulus;response to external stimulus;protein metabolic process;ovulation cycle;response to misfolded protein;positive regulation of catabolic process;regulation of catabolic process;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;positive regulation of inclusion body assembly;positive regulation of RNA metabolic process;neuron projection development;intracellular signal transduction;regulation of biological process;myelination;cell morphogenesis;exocytosis;regulation of developmental process;positive regulation of immune system process;regulation of immune system process;organic cyclic compound metabolic process;heterocycle biosynthetic process;positive regulation of reactive oxygen species metabolic process;lipid metabolic process;oligodendrocyte differentiation;regulation of reactive oxygen species metabolic process;macromolecule modification;reproduction;RNA metabolic process;response to potassium ion;positive regulation of macromolecule biosynthetic process;neuron projection morphogenesis;positive regulation of signal transduction;single-organism membrane organization;cellular component biogenesis;positive regulation of cellular amide metabolic process;negative regulation of cellular component organization;regulation of cellular component organization;regulation of protein catabolic process;response to light stimulus;glial cell differentiation;beta-amyloid metabolic process;microglial cell activation;protein modification by small protein conjugation;anatomical structure morphogenesis;positive regulation of nitric oxide metabolic process;positive regulation of cell proliferation;regulation of body fluid levels;cell proliferation;cellular response to DNA damage stimulus;neuronal signal transduction;cellular protein catabolic process;central nervous system myelin maintenance;cell projection organization;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;regulation of transferase activity;macrophage proliferation;microglial cell proliferation;cell death;nitric oxide metabolic process;modification-dependent macromolecule catabolic process;regulation of cellular macromolecule biosynthetic process;multicellular organism development;positive regulation of apoptotic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of cell death;negative regulation of programmed cell death;positive regulation of programmed cell death;protein phosphorylation;regulation of nucleobase-containing compound metabolic process;innate immune response;protein complex assembly;cellular protein modification process;single-organism developmental process;single-organism transport;single-organism cellular process;cell projection morphogenesis;anatomical structure development;release of cytochrome c from mitochondria;phosphate-containing compound metabolic process;phosphorus metabolic process;regulation of protein oligomerization;negative regulation of signaling;negative regulation of cellular process;positive regulation of cellular process;protein localization;plasma membrane organization;signal transduction;humoral immune response mediated by circulating immunoglobulin;regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;mitochondrion organization;leukocyte proliferation;single-organism metabolic process;inclusion body assembly;endomembrane system organization;response to growth factor;positive regulation of molecular function;macromolecule localization;regulation of intrinsic apoptotic signaling pathway in response to DNA damage;beta-amyloid formation;response to metal ion;regulation of RNA biosynthetic process;negative regulation of response to DNA damage stimulus;regulation of response to DNA damage stimulus;response to other organism;response to organic substance;multi-organism process;cellular catabolic process;protein ubiquitination;sterol transport;organic hydroxy compound transport;protein stabilization;leukocyte activation;nitrogen compound metabolic process;nitric oxide biosynthetic process;cellular protein metabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;neuron death;beta-amyloid clearance;positive regulation of tumor necrosis factor production;reactive oxygen species biosynthetic process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;positive regulation of neuron death;regulation of neuron death;establishment of localization;chaperone-mediated protein folding;response to stimulus;proteasomal protein catabolic process;positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;ubiquitin-dependent protein catabolic process;peptide metabolic process;positive regulation of phosphorus metabolic process;protein complex biogenesis;response to radiation;cellular response to chemical stimulus;protein folding;single-organism process;negative regulation of protein metabolic process;immunoglobulin mediated immune response;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;localization;positive regulation of protein ubiquitination;regulation of protein modification process;regulation of protein ubiquitination;positive regulation of intrinsic apoptotic signaling pathway;negative regulation of intrinsic apoptotic signaling pathway;regulation of intrinsic apoptotic signaling pathway;multicellular organismal reproductive process;positive regulation of transferase activity;regulation of macromolecule biosynthetic process;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of RNA biosynthetic process;system development;macromolecular complex subunit organization;cellular macromolecular complex assembly;regulation of apoptotic process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;positive regulation of cellular protein catabolic process;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;regulation of proteasomal protein catabolic process;reproductive process;reactive oxygen species metabolic process;response to chemical;neurogenesis;cellular protein complex assembly;organelle organization;primary metabolic process;cellular metabolic process;negative regulation of apoptotic signaling pathway;positive regulation of apoptotic signaling pathway;positive regulation of proteasomal ubiquitin-dependent protein catabolic process;regulation of metabolic process;regulation of apoptotic signaling pathway;negative regulation of response to stimulus;positive regulation of response to stimulus;cell development;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;negative regulation of signal transduction;regulation of signal transduction;cellular developmental process;rhythmic process;animal organ development;positive regulation of tau-protein kinase activity;positive regulation of biological process;negative regulation of biological process;regulation of cell proliferation;positive regulation of sequence-specific DNA binding transcription factor activity;establishment of protein localization;regulation of sequence-specific DNA binding transcription factor activity;single organism signaling;single organism reproductive process;organonitrogen compound metabolic process;vesicle-mediated transport;single-multicellular organism process;central nervous system myelination;myeloid leukocyte activation;immune system process;regulation of tau-protein kinase activity;cellular response to stress;positive regulation of beta-amyloid formation;regulation of beta-amyloid formation;cellular component assembly;positive regulation of kinase activity;negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;amyloid precursor protein catabolic process;nucleic acid-templated transcription;amyloid precursor protein metabolic process;regulation of kinase activity;regulated exocytosis;transport;defense response;programmed cell death;response to stress;negative regulation of beta-amyloid formation;complement activation;immune response;negative regulation of intracellular signal transduction;positive regulation of intracellular signal transduction;complement activation, classical pathway;regulation of intracellular signal transduction;proteolysis involved in cellular protein catabolic process;secretion;cellular nitrogen compound biosynthetic process;regulation of response to stress;regulation of cellular response to stress;cell activation;regulation of transcription, DNA-templated;coagulation;transcription, DNA-templated;endocrine pancreas development;pancreas development;regulation of amyloid precursor protein catabolic process;positive regulation of nitric oxide biosynthetic process;positive regulation of amyloid precursor protein catabolic process;regulation of neurofibrillary tangle assembly;positive regulation of neurofibrillary tangle assembly;nucleobase-containing compound metabolic process;humoral immune response;proteasome-mediated ubiquitin-dependent protein catabolic process;regulation of protein modification by small protein conjugation or removal;positive regulation of protein modification by small protein conjugation or removal;positive regulation of cellular protein metabolic process;proteolysis;developmental process;multicellular organismal process;multicellular organism reproduction;positive regulation of proteolysis involved in cellular protein catabolic process;positive regulation of cellular catabolic process;regulation of proteolysis involved in cellular protein catabolic process;cellular process;modification-dependent protein catabolic process;regulation of nucleic acid-templated transcription;protein oligomerization;regulation of immune response;cellular response to growth factor stimulus;regulation of RNA metabolic process;positive regulation of immune response;macromolecule biosynthetic process;cytokine production;regulation of cytokine production;response to topologically incorrect protein;positive regulation of cytokine production;positive regulation of protein modification process;B cell mediated immunity;macrophage activation;reactive nitrogen species metabolic process;positive regulation of phosphate metabolic process;regulation of phosphate metabolic process;regulation of gene expression;platelet degranulation;cellular component morphogenesis;organic substance metabolic process;cellular response to organic substance;tumor necrosis factor superfamily cytokine production;organic substance transport;apoptotic process;regulation of phosphorus metabolic process;biosynthetic process;estrous cycle;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;catabolic process;macromolecule catabolic process;single-organism localization;myelin maintenance;protein activation cascade;nucleobase-containing compound biosynthetic process;response to abiotic stimulus;regulation of primary metabolic process;membrane organization;RNA biosynthetic process;response to inorganic substance;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;response to virus;protein modification by small protein conjugation or removal;response to wounding;cell differentiation;regulation of macromolecule metabolic process;regulation of proteolysis;protein catabolic process;lipid localization;platelet activation;negative regulation of amyloid precursor protein catabolic process;regulation of reactive oxygen species biosynthetic process;regulation of nitric oxide biosynthetic process;aromatic compound biosynthetic process;tumor necrosis factor production;glial cell development;secretion by cell;positive regulation of tumor necrosis factor superfamily cytokine production;regulation of tumor necrosis factor superfamily cytokine production;ensheathment of neurons;organic substance biosynthetic process;organic substance catabolic process;regulation of cellular protein catabolic process;cellular component organization;macromolecular complex assembly;biological regulation;positive regulation of proteasomal protein catabolic process;regulation of biological quality;positive regulation of cellular component organization;chaperone-mediated protein complex assembly;gliogenesis;wound healing;glial cell proliferation;protein modification process;biological_process;metabolic process;oligodendrocyte development;regulation of protein complex assembly;regulation of protein stability;positive regulation of protein catabolic process;regulation of neuronal signal transduction;lipid transport;phosphorylation;cholesterol transport;positive regulation of signaling;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;positive regulation of cell communication;regulation of cell communication;positive regulation of catalytic activity;central nervous system development;regulation of beta-amyloid clearance;axon ensheathment in central nervous system;protein import;positive regulation of cell differentiation;regulation of cell differentiation;positive regulation of transcription, DNA-templated;neurofibrillary tangle assembly;positive regulation of NF-kappaB transcription factor activity;apoptotic mitochondrial changes;regulation of cellular protein metabolic process;aging;intrinsic apoptotic signaling pathway in response to DNA damage;cellular amide metabolic process;positive regulation of developmental process;macromolecule metabolic process;positive regulation of gene expression;positive regulation of proteolysis;positive regulation of protein kinase activity;reverse cholesterol transport;regulation of cellular catabolic process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;positive regulation of cell death;regulation of cell death;protein complex subunit organization;regulation of cellular component biogenesis;protein homooligomerization;positive regulation of nucleic acid-templated transcription;gene expression;positive regulation of reactive oxygen species biosynthetic process;negative regulation of protein oligomerization;negative regulation of protein homooligomerization;regulation of protein homooligomerization;neuron development;negative regulation of protein complex assembly;cellular aromatic compound metabolic process;lymphocyte mediated immunity;cell communication;leukocyte mediated immunity;generation of neurons;cell part morphogenesis;nervous system development;regulation of tumor necrosis factor production;adaptive immune response;activation of immune response;immune effector process;protein transport;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular component biogenesis; 5;5;4;3;8;4;3;7;5;5;3;4;7;7;3;3;4;3;5;4;4;3;3;4;4;5;5;5;2;6;5;5;3;3;3;4;5;5;4;6;5;5;2;5;6;5;6;4;4;3;5;4;4;5;5;6;6;6;8;3;5;4;4;3;5;5;6;7;4;5;6;5;5;5;4;5;6;6;4;6;5;6;4;5;5;7;5;4;5;6;3;4;3;5;3;6;5;4;5;3;3;3;4;5;4;5;8;5;4;3;5;4;5;4;3;6;7;5;6;4;5;3;4;2;4;9;6;5;5;3;3;5;5;5;4;5;4;6;4;4;4;3;3;5;5;3;4;2;6;8;8;5;5;4;4;4;3;2;5;7;3;5;5;2;8;6;8;6;6;6;3;6;5;5;5;5;6;4;4;6;6;9;6;5;6;7;2;4;3;6;6;4;3;3;5;5;8;3;5;3;3;4;5;2;4;4;4;2;4;9;2;2;4;5;4;4;3;3;4;5;3;7;4;2;8;4;6;6;4;7;5;6;7;5;6;6;4;4;5;3;6;4;3;5;5;5;5;6;5;5;4;4;4;6;4;6;4;4;6;6;6;5;5;4;4;7;7;7;5;5;2;2;3;7;5;7;2;7;7;6;4;6;5;4;5;4;4;4;4;6;6;5;4;6;6;5;7;4;3;5;5;5;6;5;3;4;4;4;4;3;5;3;6;3;5;3;4;4;6;4;4;4;4;7;4;5;4;6;5;4;5;6;5;5;5;6;5;4;5;5;4;4;4;6;3;5;2;7;3;4;7;7;5;4;5;1;2;6;4;4;5;5;5;6;7;3;4;4;2;4;5;3;4;4;5;5;4;6;5;4;4;6;6;6;6;5;4;6;5;3;4;5;6;8;8;5;5;5;4;4;4;5;4;4;5;3;7;7;5;5;6;7;6;5;5;4;5;4;4;7;5;5;6;4;3;3;5;7;7;3; GO:0034358;GO:0034774;GO:0044429;GO:0044424;GO:0044421;GO:0044422;GO:0097418;GO:0044463;GO:0044464;GO:0005615;GO:0070062;GO:0016023;GO:0016020;GO:0034364;GO:0034366;GO:0042995;GO:0043234;GO:0043230;GO:0043231;GO:0043233;GO:0005829;GO:0072562;GO:0044433;GO:0030141;GO:1990777;GO:0060205;GO:0031091;GO:0031090;GO:0031093;GO:0016234;GO:0016235;GO:0042583;GO:0005783;GO:0031974;GO:0031975;GO:0036477;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0012505;GO:0031982;GO:0044446;GO:0044444;GO:0031012;GO:0005737;GO:0005634;GO:0005739;GO:0043005;GO:0005740;GO:0097440;GO:0099503;GO:0030427;GO:0030426;GO:0030425;GO:0031988;GO:0005794;GO:0031967;GO:0031966;GO:0048471;GO:0097708;GO:1903561;GO:0031410;GO:0009986;GO:0005623;GO:0031983;GO:0097458;GO:0032994;GO:0032991;GO:0005575;GO:0005576; plasma lipoprotein particle;secretory granule lumen;mitochondrial part;intracellular part;extracellular region part;organelle part;neurofibrillary tangle;cell projection part;cell part;extracellular space;extracellular exosome;cytoplasmic, membrane-bounded vesicle;membrane;high-density lipoprotein particle;spherical high-density lipoprotein particle;cell projection;protein complex;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;blood microparticle;cytoplasmic vesicle part;secretory granule;lipoprotein particle;cytoplasmic membrane-bounded vesicle lumen;platelet alpha granule;organelle membrane;platelet alpha granule lumen;inclusion body;aggresome;chromaffin granule;endoplasmic reticulum;membrane-enclosed lumen;envelope;somatodendritic compartment;intracellular organelle;intracellular;membrane-bounded organelle;organelle;endomembrane system;vesicle;intracellular organelle part;cytoplasmic part;extracellular matrix;cytoplasm;nucleus;mitochondrion;neuron projection;mitochondrial envelope;apical dendrite;secretory vesicle;site of polarized growth;growth cone;dendrite;membrane-bounded vesicle;Golgi apparatus;organelle envelope;mitochondrial membrane;perinuclear region of cytoplasm;intracellular vesicle;extracellular vesicle;cytoplasmic vesicle;cell surface;cell;vesicle lumen;neuron part;protein-lipid complex;macromolecular complex;cellular_component;extracellular region; 3;5;4;3;2;2;4;3;2;3;4;5;2;4;5;3;3;3;4;3;5;3;4;4;4;5;5;3;6;4;5;5;4;2;3;4;3;3;3;2;3;4;3;4;2;4;5;5;4;5;6;6;3;4;5;5;4;4;4;5;4;3;5;3;2;4;3;3;2;1;2; GO:0051787;GO:0005488;GO:0019899;GO:0031625;GO:0005515;GO:0003674;GO:0051087;GO:0044389; misfolded protein binding;binding;enzyme binding;ubiquitin protein ligase binding;protein binding;molecular_function;chaperone binding;ubiquitin-like protein ligase binding; 4;2;4;6;3;1;4;5; K17252 map04610; Complement and coagulation cascades; IPR000753;IPR016015;IPR016016;IPR016014;IPR033986; Clusterin-like;Clusterin, C-terminal;Clusterin;Clusterin, N-terminal;Clusterin, conserved site; extracellular P01597 Immunoglobulin kappa variable 1-39 OS=Homo sapiens OX=9606 GN=IGKV1-39 PE=1 SV=2 - [KV139_HUMAN] 1.181 1.084 0.838 0.993 1.096 0.879 1.089483395 0.163601986 0.906021898 0.033978711 0.773062731 0.001275634 0.802007299 0.981675601 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q9H251 Cadherin-23 OS=Homo sapiens OX=9606 GN=CDH23 PE=1 SV=2 - [CAD23_HUMAN] 1.12 0.835 1.351 0.938 0.767 1.281 1.341317365 nan 1.222946545 nan 1.617964072 nan 1.670143416 nan GO:0060249;GO:0048468;GO:0007610;GO:0055074;GO:0098771;GO:0001894;GO:0071840;GO:0048869;GO:0048513;GO:0019725;GO:0007605;GO:0007601;GO:0007600;GO:0070838;GO:0098742;GO:0003008;GO:0048871;GO:0044707;GO:0048878;GO:0016043;GO:0065007;GO:0050954;GO:0065008;GO:0050957;GO:0007626;GO:0098609;GO:0006812;GO:0006811;GO:0006810;GO:0006816;GO:0050953;GO:0008150;GO:0051234;GO:0007423;GO:0050896;GO:0045494;GO:0050801;GO:0030154;GO:0060119;GO:0060113;GO:0044699;GO:0072507;GO:0072503;GO:0050885;GO:0022610;GO:0032502;GO:0032501;GO:0006875;GO:0006874;GO:0009987;GO:0006873;GO:0030001;GO:0030003;GO:0055080;GO:0055082;GO:0001895;GO:0048839;GO:0072511;GO:0042490;GO:0048731;GO:0030030;GO:0016339;GO:0042592;GO:0050905;GO:0007275;GO:0043583;GO:0050877;GO:0048666;GO:0030182;GO:0044767;GO:0060122;GO:0044765;GO:0044763;GO:0055065;GO:0007155;GO:0022008;GO:0007156;GO:0051179;GO:1902578;GO:0048699;GO:0007399;GO:0051480;GO:0048856; anatomical structure homeostasis;cell development;behavior;calcium ion homeostasis;inorganic ion homeostasis;tissue homeostasis;cellular component organization or biogenesis;cellular developmental process;animal organ development;cellular homeostasis;sensory perception of sound;visual perception;sensory perception;divalent metal ion transport;cell-cell adhesion via plasma-membrane adhesion molecules;system process;multicellular organismal homeostasis;single-multicellular organism process;chemical homeostasis;cellular component organization;biological regulation;sensory perception of mechanical stimulus;regulation of biological quality;equilibrioception;locomotory behavior;cell-cell adhesion;cation transport;ion transport;transport;calcium ion transport;sensory perception of light stimulus;biological_process;establishment of localization;sensory organ development;response to stimulus;photoreceptor cell maintenance;ion homeostasis;cell differentiation;inner ear receptor cell development;inner ear receptor cell differentiation;single-organism process;divalent inorganic cation homeostasis;cellular divalent inorganic cation homeostasis;neuromuscular process controlling balance;biological adhesion;developmental process;multicellular organismal process;cellular metal ion homeostasis;cellular calcium ion homeostasis;cellular process;cellular ion homeostasis;metal ion transport;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;retina homeostasis;inner ear development;divalent inorganic cation transport;mechanoreceptor differentiation;system development;cell projection organization;calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;homeostatic process;neuromuscular process;multicellular organism development;ear development;neurological system process;neuron development;neuron differentiation;single-organism developmental process;inner ear receptor stereocilium organization;single-organism transport;single-organism cellular process;metal ion homeostasis;cell adhesion;neurogenesis;homophilic cell adhesion via plasma membrane adhesion molecules;localization;single-organism localization;generation of neurons;nervous system development;regulation of cytosolic calcium ion concentration;anatomical structure development; 5;4;2;9;7;5;2;4;4;4;7;7;5;8;5;3;4;3;5;3;2;6;3;6;3;4;6;5;4;9;6;1;3;4;2;4;6;5;6;5;2;8;8;6;2;2;2;8;9;2;6;7;7;7;5;6;4;7;7;4;4;6;4;5;4;5;4;5;6;3;5;4;3;8;3;6;6;2;3;7;5;10;3; GO:0016021;GO:0016020;GO:0098862;GO:0032420;GO:0042995;GO:0098858;GO:0044425;GO:0044422;GO:0043226;GO:0031224;GO:0005886;GO:0044464;GO:0005623;GO:0032421;GO:0071944;GO:0097458;GO:0005575; integral component of membrane;membrane;cluster of actin-based cell projections;stereocilium;cell projection;actin-based cell projection;membrane part;organelle part;organelle;intrinsic component of membrane;plasma membrane;cell part;cell;stereocilium bundle;cell periphery;neuron part;cellular_component; 4;2;3;3;3;4;2;2;2;3;3;2;2;4;3;3;1; GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0046872; molecular_function;binding;cation binding;ion binding;calcium ion binding;metal ion binding; 1;2;4;3;6;5; K06813 IPR002126;IPR020894;IPR015919;IPR033030; Cadherin;Cadherin conserved site;Cadherin-like;Cadherin-23; plasma membrane Hs16507962 6804.0 S [S] Function unknown; O43307 Rho guanine nucleotide exchange factor 9 OS=Homo sapiens OX=9606 GN=ARHGEF9 PE=1 SV=3 - [ARHG9_HUMAN] 1.229 1.18 0.992 0.909 0.933 0.725 1.041525424 nan 0.974276527 nan 0.840677966 nan 0.777063237 nan GO:0007166;GO:0051234;GO:0035023;GO:0048011;GO:0007266;GO:0007165;GO:0070887;GO:0023051;GO:0010942;GO:0007169;GO:0035556;GO:0042981;GO:0050789;GO:0044699;GO:0051716;GO:0007264;GO:0010646;GO:0042221;GO:0009966;GO:0070848;GO:0008219;GO:0051179;GO:0043065;GO:0043067;GO:0065007;GO:0006810;GO:0048518;GO:0097190;GO:0071310;GO:0043068;GO:0010033;GO:0051056;GO:0006915;GO:0038179;GO:0007167;GO:0048583;GO:0006811;GO:0009987;GO:0050794;GO:0012501;GO:0044765;GO:0008150;GO:0023052;GO:0007268;GO:0007267;GO:0007154;GO:0007265;GO:1902531;GO:0055085;GO:1902578;GO:0044700;GO:0071363;GO:0046578;GO:0034220;GO:0050896;GO:0098916;GO:0044763;GO:0010941;GO:0048522;GO:0099536;GO:0099537; cell surface receptor signaling pathway;establishment of localization;regulation of Rho protein signal transduction;neurotrophin TRK receptor signaling pathway;Rho protein signal transduction;signal transduction;cellular response to chemical stimulus;regulation of signaling;positive regulation of cell death;transmembrane receptor protein tyrosine kinase signaling pathway;intracellular signal transduction;regulation of apoptotic process;regulation of biological process;single-organism process;cellular response to stimulus;small GTPase mediated signal transduction;regulation of cell communication;response to chemical;regulation of signal transduction;response to growth factor;cell death;localization;positive regulation of apoptotic process;regulation of programmed cell death;biological regulation;transport;positive regulation of biological process;apoptotic signaling pathway;cellular response to organic substance;positive regulation of programmed cell death;response to organic substance;regulation of small GTPase mediated signal transduction;apoptotic process;neurotrophin signaling pathway;enzyme linked receptor protein signaling pathway;regulation of response to stimulus;ion transport;cellular process;regulation of cellular process;programmed cell death;single-organism transport;biological_process;signaling;synaptic transmission;cell-cell signaling;cell communication;Ras protein signal transduction;regulation of intracellular signal transduction;transmembrane transport;single-organism localization;single organism signaling;cellular response to growth factor stimulus;regulation of Ras protein signal transduction;ion transmembrane transport;response to stimulus;anterograde trans-synaptic signaling;single-organism cellular process;regulation of cell death;positive regulation of cellular process;synaptic signaling;trans-synaptic signaling; 5;3;8;7;8;4;4;3;4;7;5;6;2;2;3;6;4;3;4;5;4;2;6;5;2;4;2;5;5;5;4;6;6;6;6;3;5;2;3;5;4;1;2;8;4;4;7;5;4;3;3;6;7;5;2;7;3;4;3;5;6; GO:0005737;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0005829; cytoplasm;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;cytosol; 4;2;2;3;1;4;3;5; GO:0005089;GO:0005088;GO:0005085;GO:0003674;GO:0098772; Rho guanyl-nucleotide exchange factor activity;Ras guanyl-nucleotide exchange factor activity;guanyl-nucleotide exchange factor activity;molecular_function;molecular function regulator; 5;4;3;1;2; K20686 IPR001452;IPR001849;IPR011993;IPR000219; SH3 domain;Pleckstrin homology domain;PH domain-like;Dbl homology (DH) domain; cytosol Hs7662108 1078.0 T [T] Signal transduction mechanisms; A7KAX9 Rho GTPase-activating protein 32 OS=Homo sapiens OX=9606 GN=ARHGAP32 PE=1 SV=1 - [RHG32_HUMAN] 1.058 1.015 0.778 1.109 1.279 1.056 1.042364532 nan 0.867083659 nan 0.766502463 nan 0.825645035 nan GO:0048583;GO:0007165;GO:0051716;GO:0009966;GO:0044700;GO:0035556;GO:0050789;GO:0065007;GO:0050794;GO:0008150;GO:1902531;GO:0050896;GO:0023052;GO:0023051;GO:0010646;GO:0044699;GO:0009987;GO:0051056;GO:0044763;GO:0007154;GO:0007264; regulation of response to stimulus;signal transduction;cellular response to stimulus;regulation of signal transduction;single organism signaling;intracellular signal transduction;regulation of biological process;biological regulation;regulation of cellular process;biological_process;regulation of intracellular signal transduction;response to stimulus;signaling;regulation of signaling;regulation of cell communication;single-organism process;cellular process;regulation of small GTPase mediated signal transduction;single-organism cellular process;cell communication;small GTPase mediated signal transduction; 3;4;3;4;3;5;2;2;3;1;5;2;2;3;4;2;2;6;3;4;6; GO:0005783;GO:0030425;GO:0005789;GO:0030054;GO:0097060;GO:0016020;GO:0005774;GO:0044437;GO:0005794;GO:0098588;GO:0098589;GO:0036477;GO:0042995;GO:0043231;GO:0043232;GO:0005829;GO:0044424;GO:0044425;GO:0044422;GO:0098590;GO:0043229;GO:0043228;GO:0043227;GO:0005856;GO:0044432;GO:0044431;GO:0005938;GO:0060076;GO:0000139;GO:0044446;GO:0005773;GO:0044444;GO:0044440;GO:0012505;GO:0042175;GO:0010008;GO:0005737;GO:0031090;GO:0044456;GO:0043005;GO:0044459;GO:0045211;GO:0014069;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0045202;GO:0015629;GO:0099572;GO:0071944;GO:0098805;GO:0044309;GO:0043226;GO:0097458;GO:0099568;GO:0005886;GO:0043197;GO:0005575;GO:0098794;GO:0005768; endoplasmic reticulum;dendrite;endoplasmic reticulum membrane;cell junction;synaptic membrane;membrane;vacuolar membrane;vacuolar part;Golgi apparatus;bounding membrane of organelle;membrane region;somatodendritic compartment;cell projection;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;membrane part;organelle part;plasma membrane region;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;cytoskeleton;endoplasmic reticulum part;Golgi apparatus part;cell cortex;excitatory synapse;Golgi membrane;intracellular organelle part;vacuole;cytoplasmic part;endosomal part;endomembrane system;nuclear outer membrane-endoplasmic reticulum membrane network;endosome membrane;cytoplasm;organelle membrane;synapse part;neuron projection;plasma membrane part;postsynaptic membrane;postsynaptic density;cell projection part;cell part;cell;intracellular;synapse;actin cytoskeleton;postsynaptic specialization;cell periphery;whole membrane;neuron spine;organelle;neuron part;cytoplasmic region;plasma membrane;dendritic spine;cellular_component;postsynapse;endosome; 4;5;3;2;3;2;4;4;4;4;3;4;3;4;4;5;3;2;2;4;3;3;3;5;4;4;4;3;5;3;5;4;5;3;3;5;4;3;2;4;3;4;4;3;2;2;3;2;6;3;3;3;5;2;3;5;3;4;1;3;4; GO:0098772;GO:0005096;GO:0030695;GO:0003674;GO:0005488;GO:0043168;GO:0035091;GO:0005543;GO:0043167;GO:0008289;GO:0060589;GO:0008047;GO:0030234; molecular function regulator;GTPase activator activity;GTPase regulator activity;molecular_function;binding;anion binding;phosphatidylinositol binding;phospholipid binding;ion binding;lipid binding;nucleoside-triphosphatase regulator activity;enzyme activator activity;enzyme regulator activity; 2;5;5;1;2;4;5;4;3;3;4;4;3; K20647 IPR001452;IPR000198;IPR001683;IPR008936; SH3 domain;Rho GTPase-activating protein domain;Phox homologous domain;Rho GTPase activation protein; nucleus Hs7662262 3265.0 T [T] Signal transduction mechanisms; P01593 Immunoglobulin kappa variable 1D-33 OS=Homo sapiens OX=9606 GN=IGKV1D-33 PE=1 SV=2 - [KVD33_HUMAN] 1.035 1.192 0.823 0.994 1.16 1.168 0.868288591 0.00021715 0.856896552 0.001056873 0.690436242 5.01E-07 1.006896552 0.51230126 GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0044710;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0002443;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;single-organism metabolic process;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;leukocyte mediated immunity;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;3;3;5;2;2;3;4;6;2;4;3;4;4;8;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0005575;GO:0016020;GO:0072562;GO:0005886;GO:0005615;GO:0071944;GO:0044464;GO:0005623;GO:0005576;GO:0044421; cellular_component;membrane;blood microparticle;plasma membrane;extracellular space;cell periphery;cell part;cell;extracellular region;extracellular region part; 1;2;3;3;3;3;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular Q8N239 Kelch-like protein 34 OS=Homo sapiens OX=9606 GN=KLHL34 PE=2 SV=1 - [KLH34_HUMAN] 0.814 1.019 1.461 0.895 0.913 0.965 0.798822375 nan 0.980284775 nan 1.433758587 nan 1.056955093 nan GO:0044237;GO:0044267;GO:0044260;GO:0071704;GO:0070647;GO:0032446;GO:0009987;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044238;GO:0019538;GO:0043170;GO:0016567; cellular metabolic process;cellular protein metabolic process;cellular macromolecule metabolic process;organic substance metabolic process;protein modification by small protein conjugation or removal;protein modification by small protein conjugation;cellular process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;metabolic process;primary metabolic process;protein metabolic process;macromolecule metabolic process;protein ubiquitination; 3;5;4;3;7;8;2;6;5;5;1;2;3;4;4;9; GO:1990234;GO:0005622;GO:0005615;GO:1902494;GO:0031461;GO:0031463;GO:0043234;GO:0032991;GO:0044464;GO:0000151;GO:0005623;GO:0005575;GO:0005576;GO:0044424;GO:0044421; transferase complex;intracellular;extracellular space;catalytic complex;cullin-RING ubiquitin ligase complex;Cul3-RING ubiquitin ligase complex;protein complex;macromolecular complex;cell part;ubiquitin ligase complex;cell;cellular_component;extracellular region;intracellular part;extracellular region part; 5;3;3;4;5;6;3;2;2;4;2;1;2;3;2; K10469 IPR011333;IPR011705;IPR015915;IPR000210;IPR017096;IPR006652; SKP1/BTB/POZ domain;BTB/Kelch-associated;Kelch-type beta propeller;BTB/POZ domain;BTB-kelch protein;Kelch repeat type 1; mitochondria Hs22054224 604.0 TR [T] Signal transduction mechanisms;[R] General function prediction only; P01591 Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4 - [IGJ_HUMAN] 1.01 1.03 0.847 1.07 1.093 1.109 0.980582524 0.721875208 0.978956999 0.112839525 0.822330097 2.27E-05 1.014638609 0.097580556 GO:0019730;GO:0060249;GO:0003014;GO:0071840;GO:0044710;GO:0043207;GO:0009617;GO:0003094;GO:0048518;GO:0051704;GO:0051707;GO:0003008;GO:0009607;GO:0044707;GO:0009605;GO:0002376;GO:0022607;GO:0009893;GO:0060267;GO:0042742;GO:0016043;GO:0065003;GO:0065007;GO:0065008;GO:0051130;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0008152;GO:0006955;GO:0043254;GO:0006959;GO:0050896;GO:0045730;GO:0070271;GO:0051128;GO:0060263;GO:0044699;GO:0032501;GO:0009987;GO:0031334;GO:0098542;GO:0001894;GO:0001895;GO:0051259;GO:0048871;GO:0043933;GO:0042592;GO:0071822;GO:0050789;GO:0032461;GO:0045087;GO:0006461;GO:0019222;GO:0097205;GO:0044087;GO:0044085;GO:0002250;GO:0019731;GO:0032459;GO:0048522;GO:0044089; antimicrobial humoral response;anatomical structure homeostasis;renal system process;cellular component organization or biogenesis;single-organism metabolic process;response to external biotic stimulus;response to bacterium;glomerular filtration;positive regulation of biological process;multi-organism process;response to other organism;system process;response to biotic stimulus;single-multicellular organism process;response to external stimulus;immune system process;cellular component assembly;positive regulation of metabolic process;positive regulation of respiratory burst;defense response to bacterium;cellular component organization;macromolecular complex assembly;biological regulation;regulation of biological quality;positive regulation of cellular component organization;regulation of cellular process;defense response;response to stress;biological_process;metabolic process;immune response;regulation of protein complex assembly;humoral immune response;response to stimulus;respiratory burst;protein complex biogenesis;regulation of cellular component organization;regulation of respiratory burst;single-organism process;multicellular organismal process;cellular process;positive regulation of protein complex assembly;defense response to other organism;tissue homeostasis;retina homeostasis;protein oligomerization;multicellular organismal homeostasis;macromolecular complex subunit organization;homeostatic process;protein complex subunit organization;regulation of biological process;positive regulation of protein oligomerization;innate immune response;protein complex assembly;regulation of metabolic process;renal filtration;regulation of cellular component biogenesis;cellular component biogenesis;adaptive immune response;antibacterial humoral response;regulation of protein oligomerization;positive regulation of cellular process;positive regulation of cellular component biogenesis; 4;5;4;2;3;4;4;6;2;2;3;3;3;3;3;2;4;3;4;5;3;5;2;3;4;3;4;3;1;2;3;4;4;2;4;4;4;4;2;2;2;4;4;5;6;6;4;4;4;5;2;5;4;5;3;5;3;3;4;5;5;3;3; GO:0072562;GO:0071749;GO:0031982;GO:0043230;GO:0043234;GO:0071752;GO:0071753;GO:0071750;GO:0071751;GO:0071756;GO:0044421;GO:0071754;GO:0043227;GO:0043226;GO:0071748;GO:0071745;GO:0071746;GO:0042571;GO:0019814;GO:0070062;GO:0005615;GO:0005576;GO:1903561;GO:0032991;GO:0005575; blood microparticle;polymeric IgA immunoglobulin complex;vesicle;extracellular organelle;protein complex;secretory dimeric IgA immunoglobulin complex;IgM immunoglobulin complex;dimeric IgA immunoglobulin complex;secretory IgA immunoglobulin complex;pentameric IgM immunoglobulin complex;extracellular region part;IgM immunoglobulin complex, circulating;membrane-bounded organelle;organelle;monomeric IgA immunoglobulin complex;IgA immunoglobulin complex;IgA immunoglobulin complex, circulating;immunoglobulin complex, circulating;immunoglobulin complex;extracellular exosome;extracellular space;extracellular region;extracellular vesicle;macromolecular complex;cellular_component; 3;5;4;3;3;7;5;6;6;5;2;4;3;2;5;5;4;3;4;4;3;2;3;2;1; GO:0003674;GO:0046983;GO:0003823;GO:0032403;GO:0042802;GO:0042803;GO:0019862;GO:0019865;GO:0005515;GO:0044877;GO:0005488; molecular_function;protein dimerization activity;antigen binding;protein complex binding;identical protein binding;protein homodimerization activity;IgA binding;immunoglobulin binding;protein binding;macromolecular complex binding;binding; 1;4;3;4;4;5;6;5;3;3;2; IPR024110; Immunoglobulin J chain; extracellular P62937 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2 - [PPIA_HUMAN] 0.882 0.917 0.933 1.798 0.834 1.006 0.961832061 nan 2.1558753 nan 1.017448201 nan 1.206235012 nan GO:0006457;GO:0050789;GO:0044267;GO:0000413;GO:1903900;GO:0044260;GO:0018193;GO:0044419;GO:0071704;GO:0019058;GO:0065007;GO:0019079;GO:0050792;GO:0009987;GO:0006464;GO:0050794;GO:0043903;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0051704;GO:0044238;GO:0018208;GO:0019538;GO:0043900;GO:0044237;GO:0043170;GO:0044764;GO:0016032;GO:0044403;GO:0045069; protein folding;regulation of biological process;cellular protein metabolic process;protein peptidyl-prolyl isomerization;regulation of viral life cycle;cellular macromolecule metabolic process;peptidyl-amino acid modification;interspecies interaction between organisms;organic substance metabolic process;viral life cycle;biological regulation;viral genome replication;regulation of viral process;cellular process;cellular protein modification process;regulation of cellular process;regulation of symbiosis, encompassing mutualism through parasitism;macromolecule modification;protein modification process;biological_process;metabolic process;multi-organism process;primary metabolic process;peptidyl-proline modification;protein metabolic process;regulation of multi-organism process;cellular metabolic process;macromolecule metabolic process;multi-organism cellular process;viral process;symbiosis, encompassing mutualism through parasitism;regulation of viral genome replication; 3;2;5;9;5;4;7;3;3;5;2;5;4;2;6;3;4;5;5;1;2;2;3;8;4;3;3;4;3;4;4;6; GO:0043231;GO:0043229;GO:0005623;GO:0005622;GO:0043227;GO:0005737;GO:0005634;GO:0043226;GO:0005576;GO:0005829;GO:0044464;GO:0005575;GO:0044444;GO:0044424; intracellular membrane-bounded organelle;intracellular organelle;cell;intracellular;membrane-bounded organelle;cytoplasm;nucleus;organelle;extracellular region;cytosol;cell part;cellular_component;cytoplasmic part;intracellular part; 4;3;2;3;3;4;5;2;2;5;2;1;4;3; GO:0016859;GO:0003674;GO:0003755;GO:0033218;GO:0042277;GO:0016853;GO:0003824;GO:0005488; cis-trans isomerase activity;molecular_function;peptidyl-prolyl cis-trans isomerase activity;amide binding;peptide binding;isomerase activity;catalytic activity;binding; 4;1;5;3;4;3;2;2; K03767 map01503; Cationic antimicrobial peptide (CAMP) resistance; IPR002130;IPR024936;IPR020892;IPR029000; Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain;Cyclophilin-type peptidyl-prolyl cis-trans isomerase;Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site;Cyclophilin-like domain; cytosol Hs10863927 339.0 O [O] Posttranslational modification, protein turnover, chaperones; Q8IYT8 Serine/threonine-protein kinase ULK2 OS=Homo sapiens OX=9606 GN=ULK2 PE=1 SV=3 - [ULK2_HUMAN] 1.046 0.914 0.855 1.226 0.982 1.8 1.144420131 0.307736541 1.248472505 0.021075369 0.935448578 0.521473035 1.83299389 0.002742281 GO:0048675;GO:0048671;GO:0048670;GO:0048589;GO:0048588;GO:0048468;GO:0007165;GO:0061387;GO:0031345;GO:0031344;GO:0071840;GO:0051716;GO:0071704;GO:0048869;GO:0045665;GO:0045664;GO:0010721;GO:0048519;GO:1990138;GO:0008361;GO:0010977;GO:0010975;GO:0044700;GO:0044707;GO:0019538;GO:0031667;GO:0032535;GO:0022604;GO:0009894;GO:0022603;GO:0008152;GO:0031175;GO:0043170;GO:0050789;GO:0044267;GO:0000904;GO:0016049;GO:0000902;GO:0044260;GO:0016043;GO:0090066;GO:0065007;GO:0048640;GO:0065008;GO:0061564;GO:0050793;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0051239;GO:0050896;GO:0019222;GO:0043412;GO:0051961;GO:0051960;GO:0048638;GO:0030308;GO:0016310;GO:0030154;GO:0051129;GO:0051128;GO:0023052;GO:0060284;GO:0009653;GO:0046777;GO:0044699;GO:0050767;GO:0006464;GO:0051241;GO:0050768;GO:0010769;GO:0060560;GO:0032502;GO:0032501;GO:0009987;GO:0045596;GO:0045595;GO:0001558;GO:0007409;GO:0032990;GO:0051093;GO:0050771;GO:0050770;GO:0010771;GO:0048731;GO:0009991;GO:0045926;GO:0031329;GO:0030030;GO:0031323;GO:0042594;GO:0007275;GO:0040007;GO:0040008;GO:0032989;GO:0048812;GO:0010506;GO:0009605;GO:0048666;GO:0048667;GO:0006468;GO:0030182;GO:0006914;GO:0048668;GO:0044767;GO:0044763;GO:0007154;GO:0022008;GO:0009056;GO:0044248;GO:0044238;GO:0048699;GO:0048858;GO:0007399;GO:0048856;GO:0044237;GO:0006796;GO:2000026;GO:0006793;GO:0048523; axon extension;negative regulation of collateral sprouting;regulation of collateral sprouting;developmental growth;developmental cell growth;cell development;signal transduction;regulation of extent of cell growth;negative regulation of cell projection organization;regulation of cell projection organization;cellular component organization or biogenesis;cellular response to stimulus;organic substance metabolic process;cellular developmental process;negative regulation of neuron differentiation;regulation of neuron differentiation;negative regulation of cell development;negative regulation of biological process;neuron projection extension;regulation of cell size;negative regulation of neuron projection development;regulation of neuron projection development;single organism signaling;single-multicellular organism process;protein metabolic process;response to nutrient levels;regulation of cellular component size;regulation of cell morphogenesis;regulation of catabolic process;regulation of anatomical structure morphogenesis;metabolic process;neuron projection development;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;cell morphogenesis involved in differentiation;cell growth;cell morphogenesis;cellular macromolecule metabolic process;cellular component organization;regulation of anatomical structure size;biological regulation;negative regulation of developmental growth;regulation of biological quality;axon development;regulation of developmental process;regulation of cellular process;response to stress;protein modification process;biological_process;regulation of multicellular organismal process;response to stimulus;regulation of metabolic process;macromolecule modification;negative regulation of nervous system development;regulation of nervous system development;regulation of developmental growth;negative regulation of cell growth;phosphorylation;cell differentiation;negative regulation of cellular component organization;regulation of cellular component organization;signaling;regulation of cell development;anatomical structure morphogenesis;protein autophosphorylation;single-organism process;regulation of neurogenesis;cellular protein modification process;negative regulation of multicellular organismal process;negative regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;cellular process;negative regulation of cell differentiation;regulation of cell differentiation;regulation of cell growth;axonogenesis;cell part morphogenesis;negative regulation of developmental process;negative regulation of axonogenesis;regulation of axonogenesis;negative regulation of cell morphogenesis involved in differentiation;system development;response to extracellular stimulus;negative regulation of growth;regulation of cellular catabolic process;cell projection organization;regulation of cellular metabolic process;response to starvation;multicellular organism development;growth;regulation of growth;cellular component morphogenesis;neuron projection morphogenesis;regulation of autophagy;response to external stimulus;neuron development;cell morphogenesis involved in neuron differentiation;protein phosphorylation;neuron differentiation;autophagy;collateral sprouting;single-organism developmental process;single-organism cellular process;cell communication;neurogenesis;catabolic process;cellular catabolic process;primary metabolic process;generation of neurons;cell projection morphogenesis;nervous system development;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;negative regulation of cellular process; 6;5;5;3;4;4;4;5;5;5;2;3;3;4;6;7;5;2;5;5;6;6;3;3;4;5;4;5;4;4;2;5;4;2;5;5;3;5;4;3;4;2;4;3;6;3;3;3;5;1;3;2;3;5;4;5;4;4;6;5;4;4;2;5;3;8;2;6;6;3;5;6;4;2;2;2;4;4;4;7;5;3;6;7;5;4;4;3;5;4;4;4;4;2;3;4;6;4;3;5;6;7;6;3;5;3;3;4;6;3;4;3;7;5;5;3;3;5;4;4;3; GO:0034045;GO:0031982;GO:0016023;GO:0016020;GO:0031988;GO:0098588;GO:0043231;GO:0044424;GO:0043229;GO:0043227;GO:0044433;GO:0097708;GO:0000407;GO:0044446;GO:0044422;GO:0012506;GO:0043226;GO:0005737;GO:0031090;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0044444;GO:0030659;GO:0005575;GO:0098805; pre-autophagosomal structure membrane;vesicle;cytoplasmic, membrane-bounded vesicle;membrane;membrane-bounded vesicle;bounding membrane of organelle;intracellular membrane-bounded organelle;intracellular part;intracellular organelle;membrane-bounded organelle;cytoplasmic vesicle part;intracellular vesicle;pre-autophagosomal structure;intracellular organelle part;organelle part;vesicle membrane;organelle;cytoplasm;organelle membrane;cytoplasmic vesicle;cell part;cell;intracellular;cytoplasmic part;cytoplasmic vesicle membrane;cellular_component;whole membrane; 4;4;5;2;5;4;4;3;3;3;4;4;5;3;2;4;2;4;3;5;2;2;3;4;5;1;3; GO:0016740;GO:0097367;GO:1901363;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0043168;GO:0000166;GO:0016301;GO:0003824;GO:0036094;GO:0016773;GO:0016772;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0043167;GO:0030554;GO:0097159;GO:0001883;GO:0001882;GO:0004674;GO:0004672; transferase activity;carbohydrate derivative binding;heterocyclic compound binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;anion binding;nucleotide binding;kinase activity;catalytic activity;small molecule binding;phosphotransferase activity, alcohol group as acceptor;transferase activity, transferring phosphorus-containing groups;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;ion binding;adenyl nucleotide binding;organic cyclic compound binding;purine nucleoside binding;nucleoside binding;protein serine/threonine kinase activity;protein kinase activity; 3;3;3;1;2;4;5;5;6;4;4;5;2;3;5;4;6;5;6;4;5;3;6;3;5;4;7;6; K08269 map04139;map04140;map04150;map04211;map04212; Regulation of mitophagy - yeast;Regulation of autophagy;mTOR signaling pathway;Longevity regulating pathway;Longevity regulating pathway - worm; IPR011009;IPR000719;IPR008271;IPR022708;IPR017441;IPR016237; Protein kinase-like domain;Protein kinase domain;Serine/threonine-protein kinase, active site;Serine/threonine-protein kinase, C-terminal;Protein kinase, ATP binding site;Serine/threonine-protein kinase, Ulk1/Ulk2; nucleus Hs7662210 2138.0 OUT [O] Posttranslational modification, protein turnover, chaperones;[U] Intracellular trafficking, secretion, and vesicular transport;[T] Signal transduction mechanisms; Q8N7X8 SIGLEC family-like protein 1 OS=Homo sapiens OX=9606 GN=SIGLECL1 PE=2 SV=1 - [SIGL1_HUMAN] 0.972 1.075 0.82 1.125 1.012 1.894 0.904186047 nan 1.111660079 nan 0.762790698 nan 1.871541502 nan GO:0005575;GO:0044425;GO:0016021;GO:0016020;GO:0031224; cellular_component;membrane part;integral component of membrane;membrane;intrinsic component of membrane; 1;2;4;2;3; IPR007110;IPR013783; Immunoglobulin-like domain;Immunoglobulin-like fold; extracellular P01599 Immunoglobulin kappa variable 1-17 OS=Homo sapiens OX=9606 GN=IGKV1-17 PE=1 SV=2 - [KV117_HUMAN] 1.059 1.073 0.718 1.239 1.088 0.83 0.98695247 0.879756887 1.138786765 0.688163114 0.669151911 0.003583242 0.762867647 0.254298844 GO:0044710;GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0006956;GO:0002443;GO:0019724;GO:0009987;GO:0006959;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0050794;GO:0006952;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0002449;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; single-organism metabolic process;phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;complement activation;leukocyte mediated immunity;B cell mediated immunity;cellular process;humoral immune response;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;regulation of cellular process;defense response;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;lymphocyte mediated immunity;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 3;5;3;3;3;2;4;5;5;2;2;3;5;3;6;6;4;7;3;3;5;2;2;3;4;4;6;2;4;3;4;4;8;3;4;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;5;4;2;7;4;4;2;4;3;3;1; GO:0005615;GO:0043227;GO:0005575;GO:1903561;GO:0016020;GO:0072562;GO:0043226;GO:0005886;GO:0031982;GO:0043230;GO:0071944;GO:0070062;GO:0044464;GO:0005623;GO:0005576;GO:0044421; extracellular space;membrane-bounded organelle;cellular_component;extracellular vesicle;membrane;blood microparticle;organelle;plasma membrane;vesicle;extracellular organelle;cell periphery;extracellular exosome;cell part;cell;extracellular region;extracellular region part; 3;3;1;3;2;3;2;3;4;3;3;4;2;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR003599;IPR013106;IPR013783;IPR007110; Immunoglobulin subtype;Immunoglobulin V-set domain;Immunoglobulin-like fold;Immunoglobulin-like domain; extracellular O43866 CD5 antigen-like OS=Homo sapiens OX=9606 GN=CD5L PE=1 SV=1 - [CD5L_HUMAN] 1.084 1.061 0.862 1.094 1.078 0.98 1.021677663 0.385217068 1.014842301 0.133912284 0.812441093 0.000143579 0.909090909 0.980109203 GO:0006968;GO:0008219;GO:0044699;GO:0002376;GO:0006915;GO:0009987;GO:0006952;GO:0012501;GO:0006950;GO:0008150;GO:0006954;GO:0050896;GO:0044763; cellular defense response;cell death;single-organism process;immune system process;apoptotic process;cellular process;defense response;programmed cell death;response to stress;biological_process;inflammatory response;response to stimulus;single-organism cellular process; 5;4;2;2;6;2;4;5;3;1;5;2;3; GO:0043227;GO:0043226;GO:0005737;GO:0070062;GO:0005615;GO:0016020;GO:0072562;GO:1903561;GO:0031982;GO:0043230;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0005576;GO:0044424;GO:0044421; membrane-bounded organelle;organelle;cytoplasm;extracellular exosome;extracellular space;membrane;blood microparticle;extracellular vesicle;vesicle;extracellular organelle;cell part;cell;intracellular;cellular_component;extracellular region;intracellular part;extracellular region part; 3;2;4;4;3;2;3;3;4;3;2;2;3;1;2;3;2; GO:0038024;GO:0060089;GO:0003674;GO:0004872;GO:0005044; cargo receptor activity;molecular transducer activity;molecular_function;receptor activity;scavenger receptor activity; 4;2;1;3;5; IPR017448;IPR001190; SRCR-like domain;SRCR domain; extracellular Hs5174411 706.0 R [R] General function prediction only; P01024 Complement C3 OS=Homo sapiens OX=9606 GN=C3 PE=1 SV=2 - [CO3_HUMAN] 1.055 0.908 1.05 1.091 0.915 1.06 1.161894273 1.08E-162 1.192349727 nan 1.156387665 1.77E-171 1.158469945 2.56E-152 GO:0043408;GO:0032026;GO:0007599;GO:0080090;GO:0048589;GO:0070372;GO:0051049;GO:0048584;GO:0048583;GO:0002437;GO:0031349;GO:0043436;GO:0072358;GO:0002703;GO:0044281;GO:0019915;GO:0002894;GO:0006909;GO:0002455;GO:0031347;GO:0032103;GO:0044710;GO:0044711;GO:0019222;GO:0009966;GO:0009967;GO:0071840;GO:0016064;GO:0050727;GO:0002891;GO:0032268;GO:0048514;GO:0016310;GO:0048518;GO:0002682;GO:0033036;GO:0002892;GO:0090207;GO:2000259;GO:0019724;GO:0007596;GO:0051050;GO:0060255;GO:0031960;GO:0002824;GO:0002822;GO:0042327;GO:2000257;GO:0032787;GO:0001796;GO:0030162;GO:0002443;GO:0050729;GO:0002673;GO:0046486;GO:0051128;GO:0010876;GO:0010033;GO:0002675;GO:0016192;GO:0042325;GO:0044700;GO:0002507;GO:0044707;GO:0009605;GO:0002706;GO:0019538;GO:0045917;GO:0072359;GO:0000165;GO:0002376;GO:0007154;GO:0010884;GO:0010883;GO:0002524;GO:1902531;GO:0002714;GO:0007165;GO:0045087;GO:0030449;GO:0009893;GO:0002883;GO:0022603;GO:0010573;GO:0010647;GO:0023051;GO:0002712;GO:2000425;GO:1901342;GO:0002920;GO:0035556;GO:0050789;GO:0006793;GO:0010866;GO:1901576;GO:0010646;GO:0044260;GO:0001798;GO:0008645;GO:0001568;GO:0043410;GO:0001816;GO:0008643;GO:0002684;GO:0019432;GO:0065007;GO:0014070;GO:0044267;GO:0051174;GO:0065008;GO:0007186;GO:0048646;GO:0001969;GO:0051130;GO:0050766;GO:0006629;GO:0050793;GO:0006810;GO:0009889;GO:0051716;GO:0042060;GO:0050794;GO:0006952;GO:0002889;GO:0006950;GO:0050817;GO:0006956;GO:0006957;GO:0006954;GO:0006955;GO:0002526;GO:0051235;GO:0006959;GO:0002885;GO:0002886;GO:0002821;GO:0002888;GO:0070613;GO:0006897;GO:0051604;GO:0043412;GO:1904018;GO:0050896;GO:0031401;GO:0010038;GO:0009058;GO:0002520;GO:0001794;GO:0002697;GO:0036211;GO:1903319;GO:0001970;GO:0007275;GO:0008150;GO:1903317;GO:0002705;GO:0097305;GO:0010562;GO:0048639;GO:0048638;GO:0006631;GO:0008152;GO:0032101;GO:0001944;GO:0006639;GO:0006638;GO:0002819;GO:0009611;GO:0023056;GO:0044249;GO:0043277;GO:0023052;GO:0009653;GO:0006958;GO:0044699;GO:0016043;GO:0009719;GO:0050764;GO:0051234;GO:0002444;GO:0051240;GO:0051246;GO:0051247;GO:0002445;GO:0070371;GO:0045745;GO:0032270;GO:0031399;GO:0002922;GO:0006508;GO:0023014;GO:0008610;GO:1903034;GO:0046463;GO:0046460;GO:0032502;GO:0032501;GO:0050878;GO:0006641;GO:0008277;GO:0009987;GO:1902533;GO:0060627;GO:0002863;GO:0002861;GO:2000427;GO:0016485;GO:0044255;GO:0032879;GO:0050776;GO:0006082;GO:0051094;GO:0009725;GO:0010575;GO:0010574;GO:0050778;GO:0043170;GO:0051239;GO:0001817;GO:0010628;GO:1903036;GO:0032570;GO:0048731;GO:0070374;GO:0080134;GO:0048545;GO:0001819;GO:0010035;GO:0051384;GO:0045927;GO:0031326;GO:0031325;GO:0002438;GO:0031323;GO:0010604;GO:0019752;GO:0006796;GO:0010827;GO:0046890;GO:0001525;GO:0010828;GO:0019220;GO:0045017;GO:0032355;GO:0040007;GO:0072376;GO:0002708;GO:0033993;GO:0040008;GO:0045765;GO:0015758;GO:0071704;GO:0010467;GO:0071702;GO:0010954;GO:0010468;GO:0006468;GO:0015749;GO:0045937;GO:0019216;GO:0002864;GO:0006464;GO:0044767;GO:0002449;GO:0044765;GO:0045862;GO:0044763;GO:0002460;GO:0045766;GO:0043627;GO:0042221;GO:0001905;GO:0030100;GO:0051179;GO:1902578;GO:1901700;GO:0044238;GO:0002699;GO:0048856;GO:0044237;GO:1901654;GO:2000026;GO:0002250;GO:0002253;GO:0002252;GO:0002866;GO:0045807;GO:0001932;GO:0001934;GO:0048522; regulation of MAPK cascade;response to magnesium ion;hemostasis;regulation of primary metabolic process;developmental growth;regulation of ERK1 and ERK2 cascade;regulation of transport;positive regulation of response to stimulus;regulation of response to stimulus;inflammatory response to antigenic stimulus;positive regulation of defense response;oxoacid metabolic process;cardiovascular system development;regulation of leukocyte mediated immunity;small molecule metabolic process;lipid storage;positive regulation of type II hypersensitivity;phagocytosis;humoral immune response mediated by circulating immunoglobulin;regulation of defense response;positive regulation of response to external stimulus;single-organism metabolic process;single-organism biosynthetic process;regulation of metabolic process;regulation of signal transduction;positive regulation of signal transduction;cellular component organization or biogenesis;immunoglobulin mediated immune response;regulation of inflammatory response;positive regulation of immunoglobulin mediated immune response;regulation of cellular protein metabolic process;blood vessel morphogenesis;phosphorylation;positive regulation of biological process;regulation of immune system process;macromolecule localization;regulation of type II hypersensitivity;regulation of triglyceride metabolic process;positive regulation of protein activation cascade;B cell mediated immunity;blood coagulation;positive regulation of transport;regulation of macromolecule metabolic process;response to corticosteroid;positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of phosphorylation;regulation of protein activation cascade;monocarboxylic acid metabolic process;regulation of type IIa hypersensitivity;regulation of proteolysis;leukocyte mediated immunity;positive regulation of inflammatory response;regulation of acute inflammatory response;glycerolipid metabolic process;regulation of cellular component organization;lipid localization;response to organic substance;positive regulation of acute inflammatory response;vesicle-mediated transport;regulation of phosphorylation;single organism signaling;tolerance induction;single-multicellular organism process;response to external stimulus;regulation of lymphocyte mediated immunity;protein metabolic process;positive regulation of complement activation;circulatory system development;MAPK cascade;immune system process;cell communication;positive regulation of lipid storage;regulation of lipid storage;hypersensitivity;regulation of intracellular signal transduction;positive regulation of B cell mediated immunity;signal transduction;innate immune response;regulation of complement activation;positive regulation of metabolic process;regulation of hypersensitivity;regulation of anatomical structure morphogenesis;vascular endothelial growth factor production;positive regulation of cell communication;regulation of signaling;regulation of B cell mediated immunity;regulation of apoptotic cell clearance;regulation of vasculature development;regulation of humoral immune response;intracellular signal transduction;regulation of biological process;phosphorus metabolic process;regulation of triglyceride biosynthetic process;organic substance biosynthetic process;regulation of cell communication;cellular macromolecule metabolic process;positive regulation of type IIa hypersensitivity;hexose transport;blood vessel development;positive regulation of MAPK cascade;cytokine production;carbohydrate transport;positive regulation of immune system process;triglyceride biosynthetic process;biological regulation;response to organic cyclic compound;cellular protein metabolic process;regulation of phosphorus metabolic process;regulation of biological quality;G-protein coupled receptor signaling pathway;anatomical structure formation involved in morphogenesis;regulation of activation of membrane attack complex;positive regulation of cellular component organization;positive regulation of phagocytosis;lipid metabolic process;regulation of developmental process;transport;regulation of biosynthetic process;cellular response to stimulus;wound healing;regulation of cellular process;defense response;regulation of immunoglobulin mediated immune response;response to stress;coagulation;complement activation;complement activation, alternative pathway;inflammatory response;immune response;acute inflammatory response;maintenance of location;humoral immune response;positive regulation of hypersensitivity;regulation of myeloid leukocyte mediated immunity;positive regulation of adaptive immune response;positive regulation of myeloid leukocyte mediated immunity;regulation of protein processing;endocytosis;protein maturation;macromolecule modification;positive regulation of vasculature development;response to stimulus;positive regulation of protein modification process;response to metal ion;biosynthetic process;immune system development;type IIa hypersensitivity;regulation of immune effector process;protein modification process;positive regulation of protein maturation;positive regulation of activation of membrane attack complex;multicellular organism development;biological_process;regulation of protein maturation;positive regulation of leukocyte mediated immunity;response to alcohol;positive regulation of phosphorus metabolic process;positive regulation of developmental growth;regulation of developmental growth;fatty acid metabolic process;metabolic process;regulation of response to external stimulus;vasculature development;acylglycerol metabolic process;neutral lipid metabolic process;regulation of adaptive immune response;response to wounding;positive regulation of signaling;cellular biosynthetic process;apoptotic cell clearance;signaling;anatomical structure morphogenesis;complement activation, classical pathway;single-organism process;cellular component organization;response to endogenous stimulus;regulation of phagocytosis;establishment of localization;myeloid leukocyte mediated immunity;positive regulation of multicellular organismal process;regulation of protein metabolic process;positive regulation of protein metabolic process;type II hypersensitivity;ERK1 and ERK2 cascade;positive regulation of G-protein coupled receptor protein signaling pathway;positive regulation of cellular protein metabolic process;regulation of protein modification process;positive regulation of humoral immune response;proteolysis;signal transduction by protein phosphorylation;lipid biosynthetic process;regulation of response to wounding;acylglycerol biosynthetic process;neutral lipid biosynthetic process;developmental process;multicellular organismal process;regulation of body fluid levels;triglyceride metabolic process;regulation of G-protein coupled receptor protein signaling pathway;cellular process;positive regulation of intracellular signal transduction;regulation of vesicle-mediated transport;positive regulation of inflammatory response to antigenic stimulus;regulation of inflammatory response to antigenic stimulus;positive regulation of apoptotic cell clearance;protein processing;cellular lipid metabolic process;regulation of localization;regulation of immune response;organic acid metabolic process;positive regulation of developmental process;response to hormone;positive regulation of vascular endothelial growth factor production;regulation of vascular endothelial growth factor production;positive regulation of immune response;macromolecule metabolic process;regulation of multicellular organismal process;regulation of cytokine production;positive regulation of gene expression;positive regulation of response to wounding;response to progesterone;system development;positive regulation of ERK1 and ERK2 cascade;regulation of response to stress;response to steroid hormone;positive regulation of cytokine production;response to inorganic substance;response to glucocorticoid;positive regulation of growth;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;acute inflammatory response to antigenic stimulus;regulation of cellular metabolic process;positive regulation of macromolecule metabolic process;carboxylic acid metabolic process;phosphate-containing compound metabolic process;regulation of glucose transport;regulation of lipid biosynthetic process;angiogenesis;positive regulation of glucose transport;regulation of phosphate metabolic process;glycerolipid biosynthetic process;response to estradiol;growth;protein activation cascade;positive regulation of lymphocyte mediated immunity;response to lipid;regulation of growth;regulation of angiogenesis;glucose transport;organic substance metabolic process;gene expression;organic substance transport;positive regulation of protein processing;regulation of gene expression;protein phosphorylation;monosaccharide transport;positive regulation of phosphate metabolic process;regulation of lipid metabolic process;regulation of acute inflammatory response to antigenic stimulus;cellular protein modification process;single-organism developmental process;lymphocyte mediated immunity;single-organism transport;positive regulation of proteolysis;single-organism cellular process;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;positive regulation of angiogenesis;response to estrogen;response to chemical;activation of membrane attack complex;regulation of endocytosis;localization;single-organism localization;response to oxygen-containing compound;primary metabolic process;positive regulation of immune effector process;anatomical structure development;cellular metabolic process;response to ketone;regulation of multicellular organismal development;adaptive immune response;activation of immune response;immune effector process;positive regulation of acute inflammatory response to antigenic stimulus;positive regulation of endocytosis;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular process; 6;6;5;4;3;7;4;3;3;4;4;5;5;5;4;4;7;5;5;5;4;3;4;3;4;4;2;7;5;8;5;4;6;2;3;3;7;5;4;6;5;3;4;6;6;6;7;4;7;8;6;4;5;6;5;4;4;4;6;5;7;3;3;3;3;6;4;5;5;5;2;4;3;4;6;5;7;4;4;5;3;7;4;5;4;3;7;7;5;5;5;2;4;6;4;4;4;8;7;4;6;4;5;3;7;2;5;5;5;3;5;3;6;4;5;4;3;4;4;3;5;3;4;8;3;4;4;5;5;3;6;3;4;7;6;5;6;7;6;5;5;4;2;6;5;3;3;7;4;5;6;6;4;1;6;5;5;5;4;4;5;2;4;5;6;5;5;4;3;4;6;2;3;5;2;3;3;6;3;5;3;5;5;6;6;5;5;6;5;5;4;5;5;6;5;2;2;4;7;5;2;5;4;5;5;6;6;4;3;4;4;3;4;5;5;4;4;3;4;5;4;6;4;7;4;5;4;4;7;3;5;4;5;4;4;6;5;5;5;4;4;6;5;6;2;3;6;5;3;5;8;3;5;5;7;5;7;6;6;5;6;6;3;5;4;6;3;5;5;6;3;5;5;2;3;4;3;4;3;3;5;4;4;3;3;6;4;7;7;3; GO:0016020;GO:0043230;GO:0044421;GO:0043227;GO:0072562;GO:0005886;GO:0031982;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0043226;GO:1903561;GO:0005615;GO:0005575;GO:0005576; membrane;extracellular organelle;extracellular region part;membrane-bounded organelle;blood microparticle;plasma membrane;vesicle;cell part;cell;cell periphery;extracellular exosome;organelle;extracellular vesicle;extracellular space;cellular_component;extracellular region; 2;3;2;3;3;3;4;2;2;3;4;2;3;3;1;2; GO:0030414;GO:0098772;GO:0003674;GO:0005488;GO:0061135;GO:0031714;GO:0031715;GO:0001664;GO:0004857;GO:0008289;GO:0048037;GO:0004866;GO:0005515;GO:0005102;GO:0030234;GO:0061134; peptidase inhibitor activity;molecular function regulator;molecular_function;binding;endopeptidase regulator activity;C5a anaphylatoxin chemotactic receptor binding;C5L2 anaphylatoxin chemotactic receptor binding;G-protein coupled receptor binding;enzyme inhibitor activity;lipid binding;cofactor binding;endopeptidase inhibitor activity;protein binding;receptor binding;enzyme regulator activity;peptidase regulator activity; 5;2;1;2;5;6;7;5;4;3;3;6;3;4;3;4; K03990 map04145;map04610;map05133;map05134;map05140;map05142;map05150;map05152;map05168;map05203;map05322; Phagosome;Complement and coagulation cascades;Pertussis;Legionellosis;Leishmaniasis;Chagas disease (American trypanosomiasis);Staphylococcus aureus infection;Tuberculosis;Herpes simplex infection;Viral carcinogenesis;Systemic lupus erythematosus; IPR011626;IPR013783;IPR009048;IPR000020;IPR008993;IPR018933;IPR019742;IPR001134;IPR001599;IPR011625;IPR008930;IPR002890;IPR035711;IPR018081;IPR001840;IPR019565; Alpha-macroglobulin complement component;Immunoglobulin-like fold;Alpha-macroglobulin, receptor-binding;Anaphylatoxin/fibulin;Tissue inhibitor of metalloproteinases-like, OB-fold;Netrin module, non-TIMP type;Alpha-2-macroglobulin, conserved site;Netrin domain;Alpha-2-macroglobulin;Alpha-2-macroglobulin, N-terminal 2;Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;Alpha-2-macroglobulin, N-terminal;Complement C3-like;Anaphylatoxin, complement system;Anaphylatoxin, complement system domain;Alpha-2-macroglobulin, thiol-ester bond-forming; endoplasmic reticulum Hs4557385 3456.0 O [O] Posttranslational modification, protein turnover, chaperones; P01023 Alpha-2-macroglobulin OS=Homo sapiens OX=9606 GN=A2M PE=1 SV=3 - [A2MG_HUMAN] 0.965 0.94 1.105 1.021 0.973 1.042 1.026595745 0.001536281 1.049331963 6.23E-49 1.175531915 4.62E-159 1.070914697 2.27E-140 GO:0007599;GO:0080090;GO:0019222;GO:0007597;GO:0007596;GO:0048583;GO:0031348;GO:0016043;GO:0071840;GO:0044710;GO:0048863;GO:0048869;GO:0009611;GO:0044092;GO:0048518;GO:0048519;GO:0002526;GO:0048585;GO:0002683;GO:2000258;GO:0030154;GO:0060255;GO:0050777;GO:2000257;GO:0050776;GO:0030162;GO:0002673;GO:0030168;GO:0044700;GO:0016192;GO:0044707;GO:0019538;GO:0002376;GO:0030198;GO:0010629;GO:0007165;GO:0030449;GO:0007264;GO:0023051;GO:0050778;GO:0002920;GO:0035556;GO:0043170;GO:0009605;GO:0044267;GO:0051346;GO:0044260;GO:0006887;GO:0045055;GO:0002684;GO:0045824;GO:0065007;GO:0031347;GO:0065009;GO:0065008;GO:0045916;GO:0050790;GO:0006810;GO:0051716;GO:0042060;GO:0050794;GO:0006952;GO:0006950;GO:0050817;GO:0008150;GO:0008152;GO:0006955;GO:0010605;GO:0051234;GO:0051336;GO:0046903;GO:0070613;GO:0051604;GO:0050896;GO:0001775;GO:0009966;GO:1903318;GO:0006956;GO:1903317;GO:0002698;GO:0006954;GO:0050727;GO:0023052;GO:1902531;GO:0009892;GO:0010646;GO:0043086;GO:0044699;GO:0051248;GO:0006959;GO:0051246;GO:0048584;GO:0001867;GO:0006508;GO:0001869;GO:0001868;GO:1903034;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0002921;GO:0016485;GO:0032269;GO:0032268;GO:0022617;GO:0032940;GO:0045861;GO:0080134;GO:0051056;GO:0031324;GO:0031323;GO:0002682;GO:0072376;GO:0072378;GO:0002576;GO:0002697;GO:0050789;GO:0032101;GO:0071704;GO:0010467;GO:0010466;GO:0043062;GO:0010468;GO:0045088;GO:0052547;GO:0052548;GO:0045087;GO:0044767;GO:0044765;GO:0044763;GO:0010951;GO:0007154;GO:0010955;GO:0051179;GO:1902578;GO:0044238;GO:0044237;GO:0002253;GO:0002252;GO:0022411;GO:0048523; hemostasis;regulation of primary metabolic process;regulation of metabolic process;blood coagulation, intrinsic pathway;blood coagulation;regulation of response to stimulus;negative regulation of defense response;cellular component organization;cellular component organization or biogenesis;single-organism metabolic process;stem cell differentiation;cellular developmental process;response to wounding;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;acute inflammatory response;negative regulation of response to stimulus;negative regulation of immune system process;negative regulation of protein activation cascade;cell differentiation;regulation of macromolecule metabolic process;negative regulation of immune response;regulation of protein activation cascade;regulation of immune response;regulation of proteolysis;regulation of acute inflammatory response;platelet activation;single organism signaling;vesicle-mediated transport;single-multicellular organism process;protein metabolic process;immune system process;extracellular matrix organization;negative regulation of gene expression;signal transduction;regulation of complement activation;small GTPase mediated signal transduction;regulation of signaling;positive regulation of immune response;regulation of humoral immune response;intracellular signal transduction;macromolecule metabolic process;response to external stimulus;cellular protein metabolic process;negative regulation of hydrolase activity;cellular macromolecule metabolic process;exocytosis;regulated exocytosis;positive regulation of immune system process;negative regulation of innate immune response;biological regulation;regulation of defense response;regulation of molecular function;regulation of biological quality;negative regulation of complement activation;regulation of catalytic activity;transport;cellular response to stimulus;wound healing;regulation of cellular process;defense response;response to stress;coagulation;biological_process;metabolic process;immune response;negative regulation of macromolecule metabolic process;establishment of localization;regulation of hydrolase activity;secretion;regulation of protein processing;protein maturation;response to stimulus;cell activation;regulation of signal transduction;negative regulation of protein maturation;complement activation;regulation of protein maturation;negative regulation of immune effector process;inflammatory response;regulation of inflammatory response;signaling;regulation of intracellular signal transduction;negative regulation of metabolic process;regulation of cell communication;negative regulation of catalytic activity;single-organism process;negative regulation of protein metabolic process;humoral immune response;regulation of protein metabolic process;positive regulation of response to stimulus;complement activation, lectin pathway;proteolysis;negative regulation of complement activation, lectin pathway;regulation of complement activation, lectin pathway;regulation of response to wounding;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;negative regulation of humoral immune response;protein processing;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;extracellular matrix disassembly;secretion by cell;negative regulation of proteolysis;regulation of response to stress;regulation of small GTPase mediated signal transduction;negative regulation of cellular metabolic process;regulation of cellular metabolic process;regulation of immune system process;protein activation cascade;blood coagulation, fibrin clot formation;platelet degranulation;regulation of immune effector process;regulation of biological process;regulation of response to external stimulus;organic substance metabolic process;gene expression;negative regulation of peptidase activity;extracellular structure organization;regulation of gene expression;regulation of innate immune response;regulation of peptidase activity;regulation of endopeptidase activity;innate immune response;single-organism developmental process;single-organism transport;single-organism cellular process;negative regulation of endopeptidase activity;cell communication;negative regulation of protein processing;localization;single-organism localization;primary metabolic process;cellular metabolic process;activation of immune response;immune effector process;cellular component disassembly;negative regulation of cellular process; 5;4;3;4;5;3;4;3;2;3;6;4;4;4;2;2;6;3;3;4;5;4;4;4;4;6;6;5;3;5;3;4;2;5;5;4;5;6;3;4;5;5;4;3;5;6;4;5;6;3;5;2;5;3;3;5;4;4;3;5;3;4;3;4;1;2;3;4;3;5;5;7;5;2;4;4;6;4;6;4;5;5;2;5;3;4;5;2;5;4;5;3;5;5;6;6;5;2;2;4;2;5;6;5;5;5;4;6;4;6;4;4;3;3;4;7;4;2;4;3;5;7;4;5;5;6;7;4;3;4;3;8;4;7;2;3;3;3;3;3;4;3; GO:0031974;GO:0031983;GO:0031982;GO:0016023;GO:0031988;GO:0099503;GO:0034774;GO:0043231;GO:0043230;GO:0043233;GO:0005829;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0043226;GO:0072562;GO:0044433;GO:0030141;GO:0012505;GO:0044446;GO:0044444;GO:0097708;GO:0060205;GO:0005737;GO:0031091;GO:0031093;GO:0031410;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:1903561;GO:0005615;GO:0005575;GO:0005576; membrane-enclosed lumen;vesicle lumen;vesicle;cytoplasmic, membrane-bounded vesicle;membrane-bounded vesicle;secretory vesicle;secretory granule lumen;intracellular membrane-bounded organelle;extracellular organelle;organelle lumen;cytosol;intracellular part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;organelle;blood microparticle;cytoplasmic vesicle part;secretory granule;endomembrane system;intracellular organelle part;cytoplasmic part;intracellular vesicle;cytoplasmic membrane-bounded vesicle lumen;cytoplasm;platelet alpha granule;platelet alpha granule lumen;cytoplasmic vesicle;cell part;cell;intracellular;extracellular exosome;extracellular vesicle;extracellular space;cellular_component;extracellular region; 2;4;4;5;5;6;5;4;3;3;5;3;2;2;3;3;2;3;4;4;3;3;4;4;5;4;5;6;5;2;2;3;4;3;3;1;2; GO:0030414;GO:0098772;GO:0019959;GO:0043120;GO:0004866;GO:0061135;GO:0003674;GO:0005488;GO:0019838;GO:0030234;GO:0005102;GO:0019958;GO:0048306;GO:0019956;GO:0019955;GO:0019899;GO:0004857;GO:0002020;GO:0004867;GO:0005515;GO:0019966;GO:0061134; peptidase inhibitor activity;molecular function regulator;interleukin-8 binding;tumor necrosis factor binding;endopeptidase inhibitor activity;endopeptidase regulator activity;molecular_function;binding;growth factor binding;enzyme regulator activity;receptor binding;C-X-C chemokine binding;calcium-dependent protein binding;chemokine binding;cytokine binding;enzyme binding;enzyme inhibitor activity;protease binding;serine-type endopeptidase inhibitor activity;protein binding;interleukin-1 binding;peptidase regulator activity; 5;2;7;5;6;5;1;2;4;3;4;6;4;5;4;4;4;5;7;3;5;4; K03910 map04610; Complement and coagulation cascades; IPR011626;IPR013783;IPR009048;IPR010916;IPR019742;IPR001599;IPR011625;IPR008930;IPR002890;IPR019565;IPR014756; Alpha-macroglobulin complement component;Immunoglobulin-like fold;Alpha-macroglobulin, receptor-binding;TonB box, conserved site;Alpha-2-macroglobulin, conserved site;Alpha-2-macroglobulin;Alpha-2-macroglobulin, N-terminal 2;Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid;Alpha-2-macroglobulin, N-terminal;Alpha-2-macroglobulin, thiol-ester bond-forming;Immunoglobulin E-set; extracellular Hs4557225 3057.0 O [O] Posttranslational modification, protein turnover, chaperones; Q6ZMT1 SH3 and cysteine-rich domain-containing protein 2 OS=Homo sapiens OX=9606 GN=STAC2 PE=1 SV=1 - [STAC2_HUMAN] 0.614 0.573 2.503 0.664 0.551 0.734 1.071553229 nan 1.20508167 nan 4.368237347 nan 1.332123412 nan GO:0007165;GO:0035556;GO:0050789;GO:0044699;GO:0051716;GO:0065007;GO:0009987;GO:0050794;GO:0008150;GO:0007154;GO:0044700;GO:0050896;GO:0044763;GO:0023052; signal transduction;intracellular signal transduction;regulation of biological process;single-organism process;cellular response to stimulus;biological regulation;cellular process;regulation of cellular process;biological_process;cell communication;single organism signaling;response to stimulus;single-organism cellular process;signaling; 4;5;2;2;3;2;2;3;1;4;3;2;3;2; GO:0044464;GO:0005623;GO:0005622;GO:0005575; cell part;cell;intracellular;cellular_component; 2;2;3;1; GO:0003674;GO:0043169;GO:0043167;GO:0046872;GO:0005488; molecular_function;cation binding;ion binding;metal ion binding;binding; 1;4;3;5;2; IPR002219;IPR001452;IPR035509; Protein kinase C-like, phorbol ester/diacylglycerol-binding domain;SH3 domain;Stac2, SH3 domain; cytosol, nucleus Hs18586669 734.0 R [R] General function prediction only; Q9UHX3 Adhesion G protein-coupled receptor E2 OS=Homo sapiens OX=9606 GN=ADGRE2 PE=1 SV=2 - [AGRE2_HUMAN] 0.857 0.969 1.437 0.908 0.954 0.888 0.884416925 nan 0.951781971 nan 1.482972136 nan 0.93081761 nan GO:0007154;GO:0050789;GO:0006928;GO:0050900;GO:0051674;GO:0070887;GO:0060326;GO:0023052;GO:0044699;GO:0007186;GO:0042330;GO:0007166;GO:0065007;GO:0097530;GO:0016477;GO:0030595;GO:0007165;GO:0006935;GO:0009987;GO:0051716;GO:0006952;GO:0006950;GO:0044763;GO:0006954;GO:0007155;GO:0042221;GO:0050794;GO:0051179;GO:0040011;GO:0044700;GO:0071621;GO:0009605;GO:0048870;GO:0022610;GO:0050896;GO:0002376;GO:0008150;GO:0097529; cell communication;regulation of biological process;movement of cell or subcellular component;leukocyte migration;localization of cell;cellular response to chemical stimulus;cell chemotaxis;signaling;single-organism process;G-protein coupled receptor signaling pathway;taxis;cell surface receptor signaling pathway;biological regulation;granulocyte migration;cell migration;leukocyte chemotaxis;signal transduction;chemotaxis;cellular process;cellular response to stimulus;defense response;response to stress;single-organism cellular process;inflammatory response;cell adhesion;response to chemical;regulation of cellular process;localization;locomotion;single organism signaling;granulocyte chemotaxis;response to external stimulus;cell motility;biological adhesion;response to stimulus;immune system process;biological_process;myeloid leukocyte migration; 4;2;4;3;3;4;5;2;2;5;3;5;2;5;4;4;4;4;2;3;4;3;3;5;3;3;3;2;2;3;5;3;3;2;2;2;1;4; GO:0098590;GO:0042995;GO:0005575;GO:0016021;GO:0016020;GO:0031224;GO:0044425;GO:0044459;GO:0098805;GO:0098589;GO:0032587;GO:0031256;GO:0031253;GO:0031252;GO:0005886;GO:0044463;GO:0044464;GO:0005623;GO:0071944;GO:0001726; plasma membrane region;cell projection;cellular_component;integral component of membrane;membrane;intrinsic component of membrane;membrane part;plasma membrane part;whole membrane;membrane region;ruffle membrane;leading edge membrane;cell projection membrane;cell leading edge;plasma membrane;cell projection part;cell part;cell;cell periphery;ruffle; 4;3;1;4;2;3;2;3;3;3;5;4;4;3;3;3;2;2;3;4; GO:0038023;GO:0004871;GO:0046872;GO:0035374;GO:0060089;GO:0003674;GO:0004872;GO:0005539;GO:0043168;GO:0004930;GO:0043167;GO:0005509;GO:1901681;GO:0043169;GO:0097367;GO:0004888;GO:0099600;GO:0005488; signaling receptor activity;signal transducer activity;metal ion binding;chondroitin sulfate binding;molecular transducer activity;molecular_function;receptor activity;glycosaminoglycan binding;anion binding;G-protein coupled receptor activity;ion binding;calcium ion binding;sulfur compound binding;cation binding;carbohydrate derivative binding;transmembrane signaling receptor activity;transmembrane receptor activity;binding; 3;2;5;4;2;1;3;4;4;5;3;6;3;4;3;4;4;2; K08443 IPR017983;IPR017981;IPR000203;IPR009030;IPR003056;IPR018097;IPR000152;IPR000832;IPR000742;IPR001881; GPCR, family 2, secretin-like, conserved site;GPCR, family 2-like;GPS motif;Growth factor receptor cysteine-rich domain;GPCR, family 2, CD97 antigen;EGF-like calcium-binding, conserved site;EGF-type aspartate/asparagine hydroxylation site;GPCR, family 2, secretin-like;EGF-like domain;EGF-like calcium-binding domain; plasma membrane Hs7305025 1697.0 T [T] Signal transduction mechanisms; Q96FW1 Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2 - [OTUB1_HUMAN] 0.891 1.172 0.923 0.86 1.172 1.623 0.760238908 nan 0.733788396 nan 0.787542662 nan 1.384812287 nan GO:0080090;GO:0019222;GO:0048585;GO:0048583;GO:0031057;GO:0031056;GO:1901360;GO:0051716;GO:0010605;GO:0006302;GO:1900045;GO:0070647;GO:0070646;GO:0032446;GO:0033182;GO:0048519;GO:0070535;GO:0070534;GO:0016570;GO:0051053;GO:0051052;GO:0006281;GO:0060255;GO:0032268;GO:0051129;GO:2001021;GO:2001020;GO:0010033;GO:0046483;GO:0019538;GO:0010639;GO:0002376;GO:0016567;GO:0033554;GO:0016568;GO:0016569;GO:0009892;GO:0071108;GO:0006807;GO:0050789;GO:0044267;GO:0044260;GO:0016043;GO:0000209;GO:1900044;GO:0016574;GO:0065007;GO:0071840;GO:1903308;GO:1903309;GO:0016579;GO:0034097;GO:0044710;GO:0050794;GO:0043412;GO:2000780;GO:0008150;GO:0008152;GO:0006955;GO:0031400;GO:0071345;GO:0050896;GO:0080135;GO:0006950;GO:0036211;GO:0045738;GO:2001251;GO:0033044;GO:0033043;GO:1902914;GO:0051128;GO:0034641;GO:0070887;GO:0044699;GO:0006139;GO:0051248;GO:0051246;GO:1902915;GO:1903320;GO:1903321;GO:0031399;GO:0031396;GO:0006508;GO:0009987;GO:0006725;GO:0006974;GO:0031397;GO:0032269;GO:0043170;GO:0033522;GO:2000779;GO:0080134;GO:1902275;GO:0043933;GO:0031324;GO:0031323;GO:0090304;GO:0006282;GO:0006325;GO:0070555;GO:0071704;GO:0071310;GO:0071347;GO:0033183;GO:0045934;GO:0019219;GO:0006464;GO:0044763;GO:0051171;GO:0051172;GO:0042221;GO:1901315;GO:1901314;GO:0006996;GO:0044238;GO:0051276;GO:0044237;GO:1902589;GO:0002250;GO:0006259;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;regulation of response to stimulus;negative regulation of histone modification;regulation of histone modification;organic cyclic compound metabolic process;cellular response to stimulus;negative regulation of macromolecule metabolic process;double-strand break repair;negative regulation of protein K63-linked ubiquitination;protein modification by small protein conjugation or removal;protein modification by small protein removal;protein modification by small protein conjugation;regulation of histone ubiquitination;negative regulation of biological process;histone H2A K63-linked ubiquitination;protein K63-linked ubiquitination;histone modification;negative regulation of DNA metabolic process;regulation of DNA metabolic process;DNA repair;regulation of macromolecule metabolic process;regulation of cellular protein metabolic process;negative regulation of cellular component organization;negative regulation of response to DNA damage stimulus;regulation of response to DNA damage stimulus;response to organic substance;heterocycle metabolic process;protein metabolic process;negative regulation of organelle organization;immune system process;protein ubiquitination;cellular response to stress;chromatin modification;covalent chromatin modification;negative regulation of metabolic process;protein K48-linked deubiquitination;nitrogen compound metabolic process;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular component organization;protein polyubiquitination;regulation of protein K63-linked ubiquitination;histone ubiquitination;biological regulation;cellular component organization or biogenesis;regulation of chromatin modification;negative regulation of chromatin modification;protein deubiquitination;response to cytokine;single-organism metabolic process;regulation of cellular process;macromolecule modification;negative regulation of double-strand break repair;biological_process;metabolic process;immune response;negative regulation of protein modification process;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;response to stress;protein modification process;negative regulation of DNA repair;negative regulation of chromosome organization;regulation of chromosome organization;regulation of organelle organization;regulation of protein polyubiquitination;regulation of cellular component organization;cellular nitrogen compound metabolic process;cellular response to chemical stimulus;single-organism process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;regulation of protein metabolic process;negative regulation of protein polyubiquitination;regulation of protein modification by small protein conjugation or removal;negative regulation of protein modification by small protein conjugation or removal;regulation of protein modification process;regulation of protein ubiquitination;proteolysis;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;negative regulation of protein ubiquitination;negative regulation of cellular protein metabolic process;macromolecule metabolic process;histone H2A ubiquitination;regulation of double-strand break repair;regulation of response to stress;regulation of chromatin organization;macromolecular complex subunit organization;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;regulation of DNA repair;chromatin organization;response to interleukin-1;organic substance metabolic process;cellular response to organic substance;cellular response to interleukin-1;negative regulation of histone ubiquitination;negative regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism cellular process;regulation of nitrogen compound metabolic process;negative regulation of nitrogen compound metabolic process;response to chemical;negative regulation of histone H2A K63-linked ubiquitination;regulation of histone H2A K63-linked ubiquitination;organelle organization;primary metabolic process;chromosome organization;cellular metabolic process;single-organism organelle organization;adaptive immune response;DNA metabolic process;negative regulation of cellular process; 4;3;3;3;5;5;4;3;4;5;10;7;6;8;6;2;7;11;4;5;5;4;4;5;4;4;5;4;4;4;5;2;9;4;6;7;3;8;3;2;5;4;3;10;10;5;2;2;7;7;7;5;3;3;5;6;1;2;3;6;6;2;4;3;5;5;6;6;5;9;4;4;4;2;4;5;5;9;7;7;6;8;5;2;4;5;8;5;4;6;6;4;6;4;4;4;5;5;5;6;3;5;7;6;5;5;6;3;4;4;3;7;7;4;3;5;3;4;4;5;3; GO:0043230;GO:0043231;GO:0044424;GO:0044421;GO:0043229;GO:0005622;GO:0043227;GO:0031982;GO:0005737;GO:0005634;GO:0044464;GO:0005623;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576; extracellular organelle;intracellular membrane-bounded organelle;intracellular part;extracellular region part;intracellular organelle;intracellular;membrane-bounded organelle;vesicle;cytoplasm;nucleus;cell part;cell;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region; 3;4;3;2;3;3;3;4;4;5;2;2;4;2;3;1;2; GO:0043130;GO:0032182;GO:0003674;GO:0005488;GO:0016787;GO:0003824;GO:0036459;GO:0101005;GO:0019899;GO:0008233;GO:0008234;GO:0019784;GO:0019783;GO:0004843;GO:0031625;GO:0005515;GO:0044389;GO:0070011; ubiquitin binding;ubiquitin-like protein binding;molecular_function;binding;hydrolase activity;catalytic activity;thiol-dependent ubiquitinyl hydrolase activity;ubiquitinyl hydrolase activity;enzyme binding;peptidase activity;cysteine-type peptidase activity;NEDD8-specific protease activity;ubiquitin-like protein-specific protease activity;thiol-dependent ubiquitin-specific protease activity;ubiquitin protein ligase binding;protein binding;ubiquitin-like protein ligase binding;peptidase activity, acting on L-amino acid peptides; 5;4;1;2;3;2;5;4;4;4;6;8;7;6;6;3;5;5; K09602 IPR019400;IPR030298;IPR016615;IPR003323; Peptidase C65, otubain;Ubiquitin thioesterase OTUB1;Ubiquitin thioesterase Otubain;OTU domain; cytosol Hs8923114 560.0 S [S] Function unknown; Q8N2H3 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PYROXD2 PE=1 SV=2 - [PYRD2_HUMAN] 1.005 0.928 1.222 0.962 0.991 1.097 1.082974138 nan 0.97073663 nan 1.316810345 nan 1.106962664 nan GO:0003824;GO:0003674;GO:0016491; catalytic activity;molecular_function;oxidoreductase activity; 2;1;3; IPR023753;IPR002937; FAD/NAD(P)-binding domain;Amine oxidase; mitochondria Hs14249308 1192.0 H [H] Coenzyme transport and metabolism; O15212 Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1 - [PFD6_HUMAN] 0.825 0.725 1.877 0.845 0.735 0.815 1.137931034 0.038899166 1.149659864 0.039003097 2.588965517 1.90E-07 1.108843537 0.216837892 GO:0022607;GO:0070271;GO:0043933;GO:0006458;GO:0044237;GO:0034622;GO:0006457;GO:0043170;GO:0071840;GO:0044267;GO:0071822;GO:0051084;GO:0016043;GO:0065003;GO:0071704;GO:0051131;GO:0009987;GO:0006461;GO:0008150;GO:0008152;GO:0043623;GO:0044238;GO:0044260;GO:0019538;GO:0044085; cellular component assembly;protein complex biogenesis;macromolecular complex subunit organization;'de novo' protein folding;cellular metabolic process;cellular macromolecular complex assembly;protein folding;macromolecule metabolic process;cellular component organization or biogenesis;cellular protein metabolic process;protein complex subunit organization;'de novo' posttranslational protein folding;cellular component organization;macromolecular complex assembly;organic substance metabolic process;chaperone-mediated protein complex assembly;cellular process;protein complex assembly;biological_process;metabolic process;cellular protein complex assembly;primary metabolic process;cellular macromolecule metabolic process;protein metabolic process;cellular component biogenesis; 4;4;4;4;3;6;3;4;2;5;5;5;3;5;3;7;2;5;1;2;6;3;4;4;3; GO:0016272;GO:0005737;GO:0043234;GO:0032991;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044424; prefoldin complex;cytoplasm;protein complex;macromolecular complex;cell part;cell;intracellular;cellular_component;intracellular part; 4;4;3;2;2;2;3;1;3; GO:0003674;GO:0051087;GO:0051082;GO:0005515;GO:0005488; molecular_function;chaperone binding;unfolded protein binding;protein binding;binding; 1;4;4;3;2; K04798 IPR002777; Prefoldin beta-like; cytosol Hs7657162 251.0 O [O] Posttranslational modification, protein turnover, chaperones; Q9UQP3 Tenascin-N OS=Homo sapiens OX=9606 GN=TNN PE=1 SV=2 - [TENN_HUMAN] 1.003 1.227 0.736 1.088 1.213 0.894 0.817440913 0.060569372 0.896949711 0.486113792 0.599837001 0.088092485 0.737015664 0.345023601 GO:0048666;GO:0030030;GO:0030154;GO:0048468;GO:0006928;GO:0007160;GO:0051674;GO:0031175;GO:0009653;GO:0007275;GO:0071840;GO:0000904;GO:0016049;GO:0040007;GO:0048869;GO:0016043;GO:0032989;GO:0044699;GO:0022610;GO:0032502;GO:0048667;GO:0031589;GO:0032501;GO:0061564;GO:0030182;GO:0009987;GO:0044767;GO:0008150;GO:0007409;GO:0048731;GO:0007155;GO:0022008;GO:0032990;GO:0051179;GO:0000902;GO:0040011;GO:0048699;GO:0016477;GO:0048858;GO:0044707;GO:0048870;GO:0048856;GO:0007399;GO:0048812;GO:0044763; neuron development;cell projection organization;cell differentiation;cell development;movement of cell or subcellular component;cell-matrix adhesion;localization of cell;neuron projection development;anatomical structure morphogenesis;multicellular organism development;cellular component organization or biogenesis;cell morphogenesis involved in differentiation;cell growth;growth;cellular developmental process;cellular component organization;cellular component morphogenesis;single-organism process;biological adhesion;developmental process;cell morphogenesis involved in neuron differentiation;cell-substrate adhesion;multicellular organismal process;axon development;neuron differentiation;cellular process;single-organism developmental process;biological_process;axonogenesis;system development;cell adhesion;neurogenesis;cell part morphogenesis;localization;cell morphogenesis;locomotion;generation of neurons;cell migration;cell projection morphogenesis;single-multicellular organism process;cell motility;anatomical structure development;nervous system development;neuron projection morphogenesis;single-organism cellular process; 5;4;5;4;4;5;3;5;3;4;2;5;3;2;4;3;4;2;2;2;6;4;2;6;6;2;3;1;7;4;3;6;5;2;5;2;7;4;5;3;3;3;5;6;3; GO:0005576;GO:0009986;GO:0044464;GO:0005623;GO:0005578;GO:0005575;GO:0031012;GO:0044421; extracellular region;cell surface;cell part;cell;proteinaceous extracellular matrix;cellular_component;extracellular matrix;extracellular region part; 2;3;2;2;3;1;2;2; K06252 map04151;map04510;map04512;map05206; PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;MicroRNAs in cancer; IPR014716;IPR013783;IPR003961;IPR014715;IPR002181;IPR000742;IPR020837;IPR033080;IPR013032; Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1;Immunoglobulin-like fold;Fibronectin type III;Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2;Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain;EGF-like domain;Fibrinogen, conserved site;Tenascin-W;EGF-like, conserved site; extracellular Hs20536645_1 2183.0 TW [T] Signal transduction mechanisms;[W] Extracellular structures; P78371 T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4 - [TCPB_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0008104;GO:0019222;GO:0060249;GO:0032212;GO:0032846;GO:1904851;GO:0032844;GO:1901362;GO:1901360;GO:0080090;GO:0044710;GO:0044711;GO:0070727;GO:0070271;GO:0006260;GO:0044093;GO:0048518;GO:0033036;GO:0051054;GO:0051052;GO:0060255;GO:0045184;GO:0044702;GO:0090670;GO:0090671;GO:0090672;GO:0046483;GO:0044703;GO:0006278;GO:0019538;GO:0010638;GO:0006275;GO:0051972;GO:0019438;GO:0051973;GO:0051130;GO:0022607;GO:0006457;GO:0009893;GO:0009891;GO:0009566;GO:0006458;GO:0050821;GO:0090666;GO:0000003;GO:0050789;GO:0044267;GO:0051347;GO:0044260;GO:0016043;GO:0065003;GO:0065007;GO:0071840;GO:0065009;GO:0065008;GO:0018130;GO:0070203;GO:0070202;GO:0070201;GO:0070200;GO:1903405;GO:0006810;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0034654;GO:0051234;GO:0061077;GO:0010604;GO:1900180;GO:1900182;GO:0044271;GO:0031647;GO:0070199;GO:0070198;GO:0010557;GO:0010556;GO:2001252;GO:0044085;GO:0033044;GO:0043085;GO:0033043;GO:0019953;GO:0051128;GO:1903827;GO:0044249;GO:0034641;GO:1904816;GO:2000278;GO:1904814;GO:1904951;GO:1901998;GO:1903829;GO:0032880;GO:0006139;GO:0034502;GO:0051084;GO:0051086;GO:0045740;GO:0007004;GO:2000573;GO:0008037;GO:0007338;GO:0009988;GO:0072594;GO:0034645;GO:0009987;GO:0006725;GO:0035036;GO:1904867;GO:1990173;GO:0007339;GO:0010833;GO:0032879;GO:1904869;GO:0090304;GO:0044699;GO:0006461;GO:0043170;GO:0006807;GO:0033365;GO:0071897;GO:0034504;GO:0060341;GO:0031328;GO:0043933;GO:0031326;GO:0031325;GO:0034622;GO:0031323;GO:0042592;GO:1904874;GO:1904871;GO:0051338;GO:1904872;GO:0051131;GO:0071822;GO:1904358;GO:2000112;GO:0032210;GO:0071704;GO:0051704;GO:0006403;GO:0000723;GO:0045935;GO:1901576;GO:0019219;GO:1904356;GO:0034613;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0043623;GO:0051179;GO:0051641;GO:0006996;GO:0044238;GO:0051276;GO:0050790;GO:0032204;GO:0032206;GO:0032200;GO:0044237;GO:1902589;GO:0006259;GO:0048522; protein localization;regulation of metabolic process;anatomical structure homeostasis;positive regulation of telomere maintenance via telomerase;positive regulation of homeostatic process;positive regulation of establishment of protein localization to telomere;regulation of homeostatic process;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;regulation of primary metabolic process;single-organism metabolic process;single-organism biosynthetic process;cellular macromolecule localization;protein complex biogenesis;DNA replication;positive regulation of molecular function;positive regulation of biological process;macromolecule localization;positive regulation of DNA metabolic process;regulation of DNA metabolic process;regulation of macromolecule metabolic process;establishment of protein localization;single organism reproductive process;RNA localization to Cajal body;telomerase RNA localization to Cajal body;telomerase RNA localization;heterocycle metabolic process;multi-organism reproductive process;RNA-dependent DNA biosynthetic process;protein metabolic process;positive regulation of organelle organization;regulation of DNA replication;regulation of telomerase activity;aromatic compound biosynthetic process;positive regulation of telomerase activity;positive regulation of cellular component organization;cellular component assembly;protein folding;positive regulation of metabolic process;positive regulation of biosynthetic process;fertilization;'de novo' protein folding;protein stabilization;scaRNA localization to Cajal body;reproduction;regulation of biological process;cellular protein metabolic process;positive regulation of transferase activity;cellular macromolecule metabolic process;cellular component organization;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;regulation of molecular function;regulation of biological quality;heterocycle biosynthetic process;regulation of establishment of protein localization to telomere;regulation of establishment of protein localization to chromosome;regulation of establishment of protein localization;establishment of protein localization to telomere;protein localization to nuclear body;transport;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;establishment of localization;chaperone-mediated protein folding;positive regulation of macromolecule metabolic process;regulation of protein localization to nucleus;positive regulation of protein localization to nucleus;cellular nitrogen compound biosynthetic process;regulation of protein stability;establishment of protein localization to chromosome;protein localization to chromosome, telomeric region;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;positive regulation of chromosome organization;cellular component biogenesis;regulation of chromosome organization;positive regulation of catalytic activity;regulation of organelle organization;sexual reproduction;regulation of cellular component organization;regulation of cellular protein localization;cellular biosynthetic process;cellular nitrogen compound metabolic process;positive regulation of protein localization to chromosome, telomeric region;regulation of DNA biosynthetic process;regulation of protein localization to chromosome, telomeric region;positive regulation of establishment of protein localization;toxin transport;positive regulation of cellular protein localization;regulation of protein localization;nucleobase-containing compound metabolic process;protein localization to chromosome;'de novo' posttranslational protein folding;chaperone mediated protein folding independent of cofactor;positive regulation of DNA replication;telomere maintenance via telomerase;positive regulation of DNA biosynthetic process;cell recognition;single fertilization;cell-cell recognition;establishment of protein localization to organelle;cellular macromolecule biosynthetic process;cellular process;cellular aromatic compound metabolic process;sperm-egg recognition;protein localization to Cajal body;protein localization to nucleoplasm;binding of sperm to zona pellucida;telomere maintenance via telomere lengthening;regulation of localization;regulation of protein localization to Cajal body;nucleic acid metabolic process;single-organism process;protein complex assembly;macromolecule metabolic process;nitrogen compound metabolic process;protein localization to organelle;DNA biosynthetic process;protein localization to nucleus;regulation of cellular localization;positive regulation of cellular biosynthetic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;cellular macromolecular complex assembly;regulation of cellular metabolic process;homeostatic process;positive regulation of telomerase RNA localization to Cajal body;positive regulation of protein localization to Cajal body;regulation of transferase activity;regulation of telomerase RNA localization to Cajal body;chaperone-mediated protein complex assembly;protein complex subunit organization;positive regulation of telomere maintenance via telomere lengthening;regulation of cellular macromolecule biosynthetic process;regulation of telomere maintenance via telomerase;organic substance metabolic process;multi-organism process;RNA localization;telomere maintenance;positive regulation of nucleobase-containing compound metabolic process;organic substance biosynthetic process;regulation of nucleobase-containing compound metabolic process;regulation of telomere maintenance via telomere lengthening;cellular protein localization;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cellular protein complex assembly;localization;cellular localization;organelle organization;primary metabolic process;chromosome organization;regulation of catalytic activity;regulation of telomere maintenance;positive regulation of telomere maintenance;telomere organization;cellular metabolic process;single-organism organelle organization;DNA metabolic process;positive regulation of cellular process; 4;3;5;6;3;4;3;5;4;4;3;4;4;4;6;4;2;3;5;5;4;4;3;5;6;5;4;3;7;4;5;6;6;5;7;4;4;3;3;4;4;4;5;6;2;2;5;6;4;3;5;2;2;3;3;5;7;6;5;7;9;4;4;3;1;2;5;3;4;4;6;4;5;4;6;8;5;5;6;3;6;5;5;3;4;5;4;4;4;6;6;3;5;3;4;4;7;5;5;6;5;6;4;5;5;5;5;2;4;4;10;8;5;5;3;7;5;2;5;4;3;6;6;7;4;5;4;5;4;6;4;4;3;5;5;4;7;5;5;6;6;3;2;4;4;5;4;5;5;5;2;3;5;3;4;4;6;2;3;4;3;5;4;4;4;6;3;4;5;3; GO:0099512;GO:0099513;GO:0031982;GO:0043209;GO:0005832;GO:0044297;GO:0043234;GO:0043230;GO:0043232;GO:0005829;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0005622;GO:0043227;GO:0005856;GO:0044430;GO:0044446;GO:0005874;GO:0005737;GO:0002199;GO:0044464;GO:0005623;GO:0070062;GO:0044444;GO:0043226;GO:0044445;GO:0015630;GO:1903561;GO:0032991;GO:0005575;GO:0005576; supramolecular fiber;polymeric cytoskeletal fiber;vesicle;myelin sheath;chaperonin-containing T-complex;cell body;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;cytosol;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;intracellular;membrane-bounded organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;microtubule;cytoplasm;zona pellucida receptor complex;cell part;cell;extracellular exosome;cytoplasmic part;organelle;cytosolic part;microtubule cytoskeleton;extracellular vesicle;macromolecular complex;cellular_component;extracellular region; 2;3;4;3;4;3;3;3;4;5;3;2;2;3;3;3;3;5;4;3;4;4;4;2;2;4;4;2;5;6;3;2;1;2; GO:0044183;GO:1901363;GO:0000166;GO:0097367;GO:0003674;GO:0005488;GO:1901265;GO:0032549;GO:0017076;GO:0005524;GO:0097159;GO:0032559;GO:0032555;GO:0032550;GO:0032553;GO:0035639;GO:0019899;GO:0051082;GO:0043167;GO:0031625;GO:0030554;GO:0005515;GO:0044389;GO:0001883;GO:0001882;GO:0036094;GO:0043168; protein binding involved in protein folding;heterocyclic compound binding;nucleotide binding;carbohydrate derivative binding;molecular_function;binding;nucleoside phosphate binding;ribonucleoside binding;purine nucleotide binding;ATP binding;organic cyclic compound binding;adenyl ribonucleotide binding;purine ribonucleotide binding;purine ribonucleoside binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;enzyme binding;unfolded protein binding;ion binding;ubiquitin protein ligase binding;adenyl nucleotide binding;protein binding;ubiquitin-like protein ligase binding;purine nucleoside binding;nucleoside binding;small molecule binding;anion binding; 4;3;4;3;1;2;4;5;5;6;3;6;5;6;4;5;4;4;3;6;6;3;5;5;4;3;4; K09494 IPR002423;IPR012716;IPR017998;IPR027409;IPR027413;IPR002194; Chaperonin Cpn60/TCP-1 family;T-complex protein 1, beta subunit;Chaperone tailless complex polypeptide 1 (TCP-1);GroEL-like apical domain;GroEL-like equatorial domain;Chaperonin TCP-1, conserved site; cytosol Hs5453603 1083.0 O [O] Posttranslational modification, protein turnover, chaperones; Q14315 Filamin-C OS=Homo sapiens OX=9606 GN=FLNC PE=1 SV=3 - [FLNC_HUMAN] 0.837 1.023 1.191 1.007 1.017 1.327 0.818181818 nan 0.990167158 nan 1.164222874 nan 1.304818092 nan GO:0022607;GO:0055001;GO:0030154;GO:0048468;GO:0051146;GO:0061061;GO:0044699;GO:0048869;GO:0034330;GO:0016043;GO:0044085;GO:0071840;GO:0032502;GO:0055002;GO:0009987;GO:0048747;GO:0044767;GO:0008150;GO:0034329;GO:0048856;GO:0044763;GO:0042692; cellular component assembly;muscle cell development;cell differentiation;cell development;striated muscle cell differentiation;muscle structure development;single-organism process;cellular developmental process;cell junction organization;cellular component organization;cellular component biogenesis;cellular component organization or biogenesis;developmental process;striated muscle cell development;cellular process;muscle fiber development;single-organism developmental process;biological_process;cell junction assembly;anatomical structure development;single-organism cellular process;muscle cell differentiation; 4;5;5;4;6;4;2;4;4;3;3;2;2;6;2;7;3;1;5;3;3;5; GO:0031674;GO:0030016;GO:0030017;GO:0043229;GO:0071944;GO:0005924;GO:0005925;GO:0043226;GO:0030055;GO:0005737;GO:0016020;GO:0016528;GO:0030018;GO:0005856;GO:0070161;GO:0042383;GO:0030054;GO:0043292;GO:0005912;GO:0005886;GO:0043232;GO:0005829;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0043228;GO:0043034;GO:0044424;GO:0044422;GO:0044449; I band;myofibril;sarcomere;intracellular organelle;cell periphery;cell-substrate adherens junction;focal adhesion;organelle;cell-substrate junction;cytoplasm;membrane;sarcoplasm;Z disc;cytoskeleton;anchoring junction;sarcolemma;cell junction;contractile fiber;adherens junction;plasma membrane;intracellular non-membrane-bounded organelle;cytosol;cell part;cell;intracellular;cellular_component;cytoplasmic part;non-membrane-bounded organelle;costamere;intracellular part;organelle part;contractile fiber part; 4;6;4;3;3;4;5;2;3;4;2;5;4;5;3;4;2;5;4;3;4;5;2;2;3;1;4;3;4;3;2;3; GO:0003674;GO:0005488;GO:0030506;GO:0008092;GO:0005515; molecular_function;binding;ankyrin binding;cytoskeletal protein binding;protein binding; 1;2;5;4;3; K04437 map04010;map04510;map05132;map05205; MAPK signaling pathway;Focal adhesion;Salmonella infection;Proteoglycans in cancer; IPR032461;IPR013783;IPR017868;IPR001298;IPR001715;IPR014756;IPR001589; Filamin C;Immunoglobulin-like fold;Filamin/ABP280 repeat-like;Filamin/ABP280 repeat;Calponin homology domain;Immunoglobulin E-set;Actinin-type actin-binding domain, conserved site; cytosol Hs4557597 5501.0 Z [Z] Cytoskeleton; P01742 Immunoglobulin heavy variable 1-69 OS=Homo sapiens OX=9606 GN=IGHV1-69 PE=1 SV=2 - [HV169_HUMAN] 0.59 1.428 0.972 0.668 1.549 0.918 0.413165266 nan 0.431245965 nan 0.680672269 nan 0.592640413 nan GO:0006909;GO:0006950;GO:0048584;GO:0048583;GO:0023052;GO:0007165;GO:0007166;GO:0002455;GO:0050789;GO:0044699;GO:0051716;GO:0006959;GO:0002764;GO:0072376;GO:0002431;GO:0002768;GO:0002433;GO:0016064;GO:0002443;GO:0071704;GO:0002684;GO:0002429;GO:0065007;GO:0048518;GO:0002682;GO:0019724;GO:0009987;GO:0006956;GO:0044238;GO:0045087;GO:0006810;GO:0038095;GO:0044710;GO:0050794;GO:0006952;GO:0002449;GO:0044765;GO:0002757;GO:0044763;GO:0008152;GO:0006955;GO:0007154;GO:0006958;GO:0051234;GO:0051179;GO:1902578;GO:0016192;GO:0038096;GO:0044700;GO:0038094;GO:0050776;GO:0006897;GO:0038093;GO:0002460;GO:0019538;GO:0050896;GO:0006898;GO:0050778;GO:0043170;GO:0002376;GO:0002250;GO:0002253;GO:0002252;GO:0008150; phagocytosis;response to stress;positive regulation of response to stimulus;regulation of response to stimulus;signaling;signal transduction;cell surface receptor signaling pathway;humoral immune response mediated by circulating immunoglobulin;regulation of biological process;single-organism process;cellular response to stimulus;humoral immune response;immune response-regulating signaling pathway;protein activation cascade;Fc receptor mediated stimulatory signaling pathway;immune response-regulating cell surface receptor signaling pathway;immune response-regulating cell surface receptor signaling pathway involved in phagocytosis;immunoglobulin mediated immune response;leukocyte mediated immunity;organic substance metabolic process;positive regulation of immune system process;immune response-activating cell surface receptor signaling pathway;biological regulation;positive regulation of biological process;regulation of immune system process;B cell mediated immunity;cellular process;complement activation;primary metabolic process;innate immune response;transport;Fc-epsilon receptor signaling pathway;single-organism metabolic process;regulation of cellular process;defense response;lymphocyte mediated immunity;single-organism transport;immune response-activating signal transduction;single-organism cellular process;metabolic process;immune response;cell communication;complement activation, classical pathway;establishment of localization;localization;single-organism localization;vesicle-mediated transport;Fc-gamma receptor signaling pathway involved in phagocytosis;single organism signaling;Fc-gamma receptor signaling pathway;regulation of immune response;endocytosis;Fc receptor signaling pathway;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains;protein metabolic process;response to stimulus;receptor-mediated endocytosis;positive regulation of immune response;macromolecule metabolic process;immune system process;adaptive immune response;activation of immune response;immune effector process;biological_process; 5;3;3;3;2;4;5;5;2;2;3;4;5;3;6;6;4;7;4;3;3;5;2;2;3;6;2;4;3;4;4;8;3;3;4;5;4;4;3;2;3;4;5;3;2;3;5;5;3;8;4;6;7;5;4;2;7;4;4;2;4;3;3;1; GO:0071944;GO:0005575;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005576; cell periphery;cellular_component;membrane;plasma membrane;cell part;cell;extracellular region; 3;1;2;3;2;2;2; GO:0003674;GO:0003823;GO:0005488; molecular_function;antigen binding;binding; 1;3;2; IPR007110;IPR013783;IPR013106; Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin V-set domain; extracellular P14778 Interleukin-1 receptor type 1 OS=Homo sapiens OX=9606 GN=IL1R1 PE=1 SV=1 - [IL1R1_HUMAN] 0.971 1.104 0.885 0.978 0.841 2.531 0.879528986 nan 1.162901308 nan 0.801630435 nan 3.009512485 nan GO:0019221;GO:0048583;GO:0007292;GO:0007165;GO:0007166;GO:0031347;GO:0051716;GO:0010035;GO:0000003;GO:0070849;GO:0070848;GO:0071331;GO:0071333;GO:0019725;GO:0010033;GO:0051704;GO:0044700;GO:0044703;GO:0044702;GO:0009605;GO:0034284;GO:0071322;GO:0071326;GO:0048878;GO:0002376;GO:0050896;GO:0000302;GO:0050789;GO:0065007;GO:0065008;GO:0034097;GO:0050794;GO:0006952;GO:0006950;GO:0008150;GO:0006954;GO:0006955;GO:0071345;GO:0080134;GO:0009611;GO:0001678;GO:0032101;GO:0009314;GO:0009266;GO:0019953;GO:0050727;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0009719;GO:1901698;GO:1903034;GO:0009746;GO:0032501;GO:0048609;GO:0032504;GO:1901701;GO:0009987;GO:0009408;GO:0055082;GO:0006979;GO:0071347;GO:0070498;GO:0042592;GO:0042593;GO:0007276;GO:0030728;GO:0070555;GO:0033500;GO:0071310;GO:0071559;GO:0010286;GO:0022414;GO:0044763;GO:0007154;GO:1901700;GO:0009628;GO:0009743;GO:0071731;GO:0009749; cytokine-mediated signaling pathway;regulation of response to stimulus;female gamete generation;signal transduction;cell surface receptor signaling pathway;regulation of defense response;cellular response to stimulus;response to inorganic substance;reproduction;response to epidermal growth factor;response to growth factor;cellular response to hexose stimulus;cellular response to glucose stimulus;cellular homeostasis;response to organic substance;multi-organism process;single organism signaling;multi-organism reproductive process;single organism reproductive process;response to external stimulus;response to monosaccharide;cellular response to carbohydrate stimulus;cellular response to monosaccharide stimulus;chemical homeostasis;immune system process;response to stimulus;response to reactive oxygen species;regulation of biological process;biological regulation;regulation of biological quality;response to cytokine;regulation of cellular process;defense response;response to stress;biological_process;inflammatory response;immune response;cellular response to cytokine stimulus;regulation of response to stress;response to wounding;cellular glucose homeostasis;regulation of response to external stimulus;response to radiation;response to temperature stimulus;sexual reproduction;regulation of inflammatory response;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;response to endogenous stimulus;response to nitrogen compound;regulation of response to wounding;response to hexose;multicellular organismal process;multicellular organismal reproductive process;multicellular organism reproduction;cellular response to oxygen-containing compound;cellular process;response to heat;cellular chemical homeostasis;response to oxidative stress;cellular response to interleukin-1;interleukin-1-mediated signaling pathway;homeostatic process;glucose homeostasis;gamete generation;ovulation;response to interleukin-1;carbohydrate homeostasis;cellular response to organic substance;response to transforming growth factor beta;heat acclimation;reproductive process;single-organism cellular process;cell communication;response to oxygen-containing compound;response to abiotic stimulus;response to carbohydrate;response to nitric oxide;response to glucose; 6;3;5;4;5;5;3;4;2;4;5;8;7;4;4;2;3;3;3;3;6;6;7;5;2;2;5;2;2;3;5;3;4;3;1;5;3;6;4;4;6;4;4;4;3;5;2;4;3;2;3;4;5;7;2;3;3;5;2;4;5;4;7;7;4;7;4;4;6;6;5;4;5;2;3;4;4;3;5;5;8; GO:0030424;GO:0016021;GO:0016020;GO:0060076;GO:0042995;GO:0043234;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0043232;GO:0043229;GO:0043228;GO:0043227;GO:0031224;GO:0031226;GO:0005634;GO:0044456;GO:0043005;GO:0009986;GO:0014069;GO:0044459;GO:0044464;GO:0005623;GO:0005622;GO:0045202;GO:0099572;GO:0071944;GO:0005615;GO:0043226;GO:0097458;GO:0098794;GO:0005887;GO:0005886;GO:0032991;GO:0005575;GO:0005576; axon;integral component of membrane;membrane;excitatory synapse;cell projection;protein complex;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;intracellular non-membrane-bounded organelle;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;intrinsic component of membrane;intrinsic component of plasma membrane;nucleus;synapse part;neuron projection;cell surface;postsynaptic density;plasma membrane part;cell part;cell;intracellular;synapse;postsynaptic specialization;cell periphery;extracellular space;organelle;neuron part;postsynapse;integral component of plasma membrane;plasma membrane;macromolecular complex;cellular_component;extracellular region; 5;4;2;3;3;3;4;3;2;2;4;3;3;3;3;4;5;2;4;3;4;3;2;2;3;2;3;3;3;2;3;3;4;3;2;1;2; GO:0060089;GO:0004896;GO:0099600;GO:0003674;GO:0005488;GO:0004909;GO:0004908;GO:0005515;GO:0005102;GO:0038023;GO:0005161;GO:0004872;GO:0004871;GO:0070851;GO:0004888; molecular transducer activity;cytokine receptor activity;transmembrane receptor activity;molecular_function;binding;interleukin-1, Type I, activating receptor activity;interleukin-1 receptor activity;protein binding;receptor binding;signaling receptor activity;platelet-derived growth factor receptor binding;receptor activity;signal transducer activity;growth factor receptor binding;transmembrane signaling receptor activity; 2;5;4;1;2;7;6;3;4;3;6;3;2;5;4; K04386 map04010;map04060;map04064;map04380;map04640;map04750;map05146;map05166; MAPK signaling pathway;Cytokine-cytokine receptor interaction;NF-kappa B signaling pathway;Osteoclast differentiation;Hematopoietic cell lineage;Inflammatory mediator regulation of TRP channels;Amoebiasis;HTLV-I infection; IPR003599;IPR007110;IPR013783;IPR013098;IPR000157;IPR004076;IPR004074;IPR015621; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin I-set;Toll/interleukin-1 receptor homology (TIR) domain;Interleukin-1 receptor type 1;Interleukin-1 receptor type I/II;Interleukin-1 receptor family; endoplasmic reticulum Q6UXB8 Peptidase inhibitor 16 OS=Homo sapiens OX=9606 GN=PI16 PE=1 SV=1 - [PI16_HUMAN] 1 1.032 0.907 1.014 1.154 1.189 0.968992248 0.472244145 0.878682842 0.036429323 0.878875969 0.207369793 1.030329289 0.623437034 GO:0043230;GO:0070062;GO:0016021;GO:0016020;GO:0044421;GO:0005575;GO:0005576;GO:0044425;GO:1903561;GO:0043227;GO:0043226;GO:0031224;GO:0031982; extracellular organelle;extracellular exosome;integral component of membrane;membrane;extracellular region part;cellular_component;extracellular region;membrane part;extracellular vesicle;membrane-bounded organelle;organelle;intrinsic component of membrane;vesicle; 3;4;4;2;2;1;2;2;3;3;2;3;4; GO:0030234;GO:0061134;GO:0098772;GO:0003674;GO:0030414;GO:0004857; enzyme regulator activity;peptidase regulator activity;molecular function regulator;molecular_function;peptidase inhibitor activity;enzyme inhibitor activity; 3;4;2;1;5;4; K20412 IPR001283;IPR018244;IPR034124;IPR014044; Cysteine-rich secretory protein, allergen V5/Tpx-1-related;Allergen V5/Tpx-1-related, conserved site;Peptidase inhibitor 16-like, SCP domain;CAP domain; extracellular Hs20555401 944.0 S [S] Function unknown; P43251 Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2 - [BTD_HUMAN] 1.104 0.997 0.98 1.002 0.986 1.081 1.107321966 0.288186735 1.016227181 0.547615412 0.982948847 0.33784472 1.096348884 0.039767024 GO:0044707;GO:0048856;GO:0019752;GO:0034641;GO:0006807;GO:0044281;GO:0044699;GO:0007417;GO:0044710;GO:0051186;GO:0007399;GO:0007275;GO:0071704;GO:1901360;GO:0046483;GO:0032502;GO:0006767;GO:0006766;GO:0032501;GO:0009987;GO:0006768;GO:0032787;GO:0044767;GO:0008150;GO:0008152;GO:0048731;GO:0043436;GO:1901564;GO:0043603;GO:0006082;GO:0044237;GO:0006790;GO:0044763; single-multicellular organism process;anatomical structure development;carboxylic acid metabolic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;small molecule metabolic process;single-organism process;central nervous system development;single-organism metabolic process;cofactor metabolic process;nervous system development;multicellular organism development;organic substance metabolic process;organic cyclic compound metabolic process;heterocycle metabolic process;developmental process;water-soluble vitamin metabolic process;vitamin metabolic process;multicellular organismal process;cellular process;biotin metabolic process;monocarboxylic acid metabolic process;single-organism developmental process;biological_process;metabolic process;system development;oxoacid metabolic process;organonitrogen compound metabolic process;cellular amide metabolic process;organic acid metabolic process;cellular metabolic process;sulfur compound metabolic process;single-organism cellular process; 3;3;6;4;3;4;2;5;3;4;5;4;3;4;4;2;6;5;2;2;5;7;3;1;2;4;5;4;5;4;3;4;3; GO:0005623;GO:0005622;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0070062;GO:0005739;GO:0005615;GO:0005759;GO:0031974;GO:1903561;GO:0031982;GO:0043230;GO:0043233;GO:0044464;GO:0043229;GO:0043231;GO:0005575;GO:0070013;GO:0044444;GO:0005576;GO:0044429;GO:0044424;GO:0044421;GO:0044422; cell;intracellular;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;extracellular exosome;mitochondrion;extracellular space;mitochondrial matrix;membrane-enclosed lumen;extracellular vesicle;vesicle;extracellular organelle;organelle lumen;cell part;intracellular organelle;intracellular membrane-bounded organelle;cellular_component;intracellular organelle lumen;cytoplasmic part;extracellular region;mitochondrial part;intracellular part;extracellular region part;organelle part; 2;3;3;2;4;3;4;5;3;5;2;3;4;3;3;2;3;4;1;4;4;2;4;3;2;2; GO:0003674;GO:0016787;GO:0047708;GO:0003824;GO:0016810;GO:0016811; molecular_function;hydrolase activity;biotinidase activity;catalytic activity;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; 1;3;6;2;4;5; K01435 map00780;map01100;map04977; Biotin metabolism;Metabolic pathways;Vitamin digestion and absorption; IPR003010;IPR012101; Carbon-nitrogen hydrolase;Biotinidase-like, eukaryotic; extracellular Hs4557373 1138.0 E [E] Amino acid transport and metabolism; Q8NGL0 Olfactory receptor 5L2 OS=Homo sapiens OX=9606 GN=OR5L2 PE=2 SV=1 - [OR5L2_HUMAN] 0.706 0.707 1.557 0.765 0.869 2.468 0.998585573 0.955210509 0.880322209 0.478111161 2.202263083 0.008796302 2.84004603 0.043667517 GO:0051716;GO:0007165;GO:0007154;GO:0009593;GO:0050789;GO:0065007;GO:0044699;GO:0007186;GO:0032501;GO:0007608;GO:0050907;GO:0050877;GO:0007606;GO:0007600;GO:0050794;GO:0050911;GO:0008150;GO:0023052;GO:0042221;GO:0003008;GO:0044700;GO:0051606;GO:0050896;GO:0044763;GO:0009987;GO:0050906; cellular response to stimulus;signal transduction;cell communication;detection of chemical stimulus;regulation of biological process;biological regulation;single-organism process;G-protein coupled receptor signaling pathway;multicellular organismal process;sensory perception of smell;detection of chemical stimulus involved in sensory perception;neurological system process;sensory perception of chemical stimulus;sensory perception;regulation of cellular process;detection of chemical stimulus involved in sensory perception of smell;biological_process;signaling;response to chemical;system process;single organism signaling;detection of stimulus;response to stimulus;single-organism cellular process;cellular process;detection of stimulus involved in sensory perception; 3;4;4;4;2;2;2;5;2;7;5;4;6;5;3;6;1;2;3;3;3;3;2;3;2;4; GO:0071944;GO:0031224;GO:0016021;GO:0016020;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044425; cell periphery;intrinsic component of membrane;integral component of membrane;membrane;plasma membrane;cell part;cell;cellular_component;membrane part; 3;3;4;2;3;2;2;1;2; GO:0038023;GO:0060089;GO:0003674;GO:0005488;GO:0004871;GO:0005549;GO:0004930;GO:0004888;GO:0004984;GO:0099600;GO:0004872; signaling receptor activity;molecular transducer activity;molecular_function;binding;signal transducer activity;odorant binding;G-protein coupled receptor activity;transmembrane signaling receptor activity;olfactory receptor activity;transmembrane receptor activity;receptor activity; 3;2;1;2;2;3;5;4;5;4;3; K04257 map04740; Olfactory transduction; IPR017452;IPR000276;IPR000725; GPCR, rhodopsin-like, 7TM;G protein-coupled receptor, rhodopsin-like;Olfactory receptor; plasma membrane O00139 Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3 - [KIF2A_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0007599;GO:0007596;GO:0007165;GO:0044707;GO:0071840;GO:0051716;GO:0048869;GO:0009611;GO:0044700;GO:0002504;GO:0002376;GO:0022607;GO:0006928;GO:0050789;GO:0048002;GO:0007067;GO:0016043;GO:0065003;GO:0065007;GO:0007049;GO:0065008;GO:0019882;GO:0019884;GO:0019886;GO:0042060;GO:0050794;GO:0007051;GO:0006950;GO:0050817;GO:0008150;GO:0048731;GO:0050896;GO:0007052;GO:0007275;GO:0070271;GO:0030154;GO:0002495;GO:0023052;GO:0044699;GO:0007264;GO:0000280;GO:1902850;GO:0032502;GO:0032501;GO:0050878;GO:0009987;GO:0007010;GO:0000226;GO:0043933;GO:1903047;GO:0090307;GO:0022402;GO:0035556;GO:0051301;GO:0071822;GO:0002478;GO:0051225;GO:0000278;GO:0006461;GO:0044767;GO:0044763;GO:0007154;GO:0070925;GO:0006996;GO:0007017;GO:0007399;GO:0048856;GO:0007018;GO:1902589;GO:0044085;GO:0048285; hemostasis;blood coagulation;signal transduction;single-multicellular organism process;cellular component organization or biogenesis;cellular response to stimulus;cellular developmental process;response to wounding;single organism signaling;antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;immune system process;cellular component assembly;movement of cell or subcellular component;regulation of biological process;antigen processing and presentation of peptide antigen;mitotic nuclear division;cellular component organization;macromolecular complex assembly;biological regulation;cell cycle;regulation of biological quality;antigen processing and presentation;antigen processing and presentation of exogenous antigen;antigen processing and presentation of exogenous peptide antigen via MHC class II;wound healing;regulation of cellular process;spindle organization;response to stress;coagulation;biological_process;system development;response to stimulus;mitotic spindle organization;multicellular organism development;protein complex biogenesis;cell differentiation;antigen processing and presentation of peptide antigen via MHC class II;signaling;single-organism process;small GTPase mediated signal transduction;nuclear division;microtubule cytoskeleton organization involved in mitosis;developmental process;multicellular organismal process;regulation of body fluid levels;cellular process;cytoskeleton organization;microtubule cytoskeleton organization;macromolecular complex subunit organization;mitotic cell cycle process;mitotic spindle assembly;cell cycle process;intracellular signal transduction;cell division;protein complex subunit organization;antigen processing and presentation of exogenous peptide antigen;spindle assembly;mitotic cell cycle;protein complex assembly;single-organism developmental process;single-organism cellular process;cell communication;organelle assembly;organelle organization;microtubule-based process;nervous system development;anatomical structure development;microtubule-based movement;single-organism organelle organization;cellular component biogenesis;organelle fission; 5;5;4;3;2;3;4;4;3;4;2;4;4;2;4;5;3;5;2;4;3;3;4;6;5;3;5;3;4;1;4;2;6;4;4;5;5;2;2;6;6;6;2;2;4;2;5;5;4;5;6;4;5;4;5;5;6;5;5;3;3;4;5;4;4;5;3;5;4;3;5; GO:0099513;GO:0031974;GO:0099512;GO:0005815;GO:0031981;GO:0031514;GO:0016020;GO:0000922;GO:0042995;GO:0043234;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0043228;GO:0005929;GO:0043227;GO:0043226;GO:0005856;GO:0044430;GO:0044446;GO:0044444;GO:0044441;GO:0036126;GO:0005871;GO:0005874;GO:0005875;GO:0005737;GO:0097228;GO:0005730;GO:0005634;GO:0097223;GO:0044463;GO:0044464;GO:0005623;GO:0005622;GO:0005819;GO:0005813;GO:0015630;GO:0032991;GO:0005575;GO:0070013; polymeric cytoskeletal fiber;membrane-enclosed lumen;supramolecular fiber;microtubule organizing center;nuclear lumen;motile cilium;membrane;spindle pole;cell projection;protein complex;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;non-membrane-bounded organelle;cilium;membrane-bounded organelle;organelle;cytoskeleton;cytoskeletal part;intracellular organelle part;cytoplasmic part;ciliary part;sperm flagellum;kinesin complex;microtubule;microtubule associated complex;cytoplasm;sperm principal piece;nucleolus;nucleus;sperm part;cell projection part;cell part;cell;intracellular;spindle;centrosome;microtubule cytoskeleton;macromolecular complex;cellular_component;intracellular organelle lumen; 3;2;2;5;5;4;2;5;3;3;4;4;3;5;4;3;2;3;3;3;3;2;5;4;3;4;3;4;5;4;4;4;4;5;5;3;3;2;2;3;5;5;6;2;1;4; GO:0016818;GO:0097367;GO:0016817;GO:0005524;GO:0003674;GO:0005488;GO:0016887;GO:1901265;GO:1901363;GO:0032549;GO:0017076;GO:0003774;GO:0003777;GO:0016787;GO:0036094;GO:0003824;GO:0097159;GO:0016462;GO:0032559;GO:0032553;GO:0035639;GO:0000166;GO:0043167;GO:0030554;GO:0032550;GO:0001882;GO:0001883;GO:0017111;GO:0032555;GO:0043168; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;carbohydrate derivative binding;hydrolase activity, acting on acid anhydrides;ATP binding;molecular_function;binding;ATPase activity;nucleoside phosphate binding;heterocyclic compound binding;ribonucleoside binding;purine nucleotide binding;motor activity;microtubule motor activity;hydrolase activity;small molecule binding;catalytic activity;organic cyclic compound binding;pyrophosphatase activity;adenyl ribonucleotide binding;ribonucleotide binding;purine ribonucleoside triphosphate binding;nucleotide binding;ion binding;adenyl nucleotide binding;purine ribonucleoside binding;nucleoside binding;purine nucleoside binding;nucleoside-triphosphatase activity;purine ribonucleotide binding;anion binding; 5;3;4;6;1;2;8;4;3;5;5;8;9;3;3;2;3;6;6;4;5;4;3;6;6;4;5;7;5;4; K10393 IPR001752;IPR027417;IPR019821; Kinesin motor domain;P-loop containing nucleoside triphosphate hydrolase;Kinesin motor domain, conserved site; cytosol, nucleus Hs4758644 1409.0 Z [Z] Cytoskeleton; P46777 60S ribosomal protein L5 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3 - [RL5_HUMAN] 1.052 0.879 1.207 0.986 1.064 0.822 1.196814562 nan 0.926691729 nan 1.373151308 nan 0.772556391 nan GO:0008104;GO:0061024;GO:0044281;GO:1901362;GO:0071840;GO:1901361;GO:0044710;GO:0070727;GO:0043043;GO:0044419;GO:0019058;GO:0046483;GO:0006364;GO:0034470;GO:0006605;GO:0045184;GO:0072657;GO:0043436;GO:1901564;GO:0051704;GO:0019538;GO:0019438;GO:0022607;GO:0019080;GO:0006613;GO:0019083;GO:0006614;GO:0006807;GO:0044033;GO:0034660;GO:0043170;GO:0000027;GO:1901576;GO:1901575;GO:0044265;GO:0044260;GO:0006886;GO:0042255;GO:0042254;GO:0016043;GO:0065003;GO:1901360;GO:0018130;GO:0042273;GO:0006810;GO:0043624;GO:0046700;GO:0019439;GO:0008150;GO:0008152;GO:0034654;GO:0034655;GO:0051234;GO:0009059;GO:0006575;GO:0016070;GO:0016071;GO:0016072;GO:0044271;GO:0044270;GO:0046907;GO:0044765;GO:0045047;GO:0043603;GO:0044802;GO:0006518;GO:0032774;GO:0044248;GO:0044249;GO:0034641;GO:0034645;GO:0043241;GO:1901566;GO:0044699;GO:0006139;GO:0070972;GO:0051179;GO:0022618;GO:0022613;GO:1901605;GO:0006612;GO:0072599;GO:0072594;GO:0009987;GO:0006725;GO:0006413;GO:0043604;GO:0033036;GO:0006082;GO:0016259;GO:0000956;GO:0033365;GO:0000184;GO:0043933;GO:0019752;GO:0090304;GO:0034622;GO:0001887;GO:0009069;GO:0071826;GO:0071822;GO:0006520;GO:0071704;GO:0010467;GO:0071702;GO:0006401;GO:0006402;GO:0044267;GO:0034613;GO:0032984;GO:0009058;GO:0044764;GO:0044763;GO:0051649;GO:0070925;GO:0009056;GO:0009057;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0006414;GO:0090150;GO:0044237;GO:1902582;GO:0044085;GO:0016032;GO:0015031;GO:0044403;GO:0006415;GO:1902580;GO:0022411;GO:0006412;GO:0006396; protein localization;membrane organization;small molecule metabolic process;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;organic cyclic compound catabolic process;single-organism metabolic process;cellular macromolecule localization;peptide biosynthetic process;interspecies interaction between organisms;viral life cycle;heterocycle metabolic process;rRNA processing;ncRNA processing;protein targeting;establishment of protein localization;protein localization to membrane;oxoacid metabolic process;organonitrogen compound metabolic process;multi-organism process;protein metabolic process;aromatic compound biosynthetic process;cellular component assembly;viral gene expression;cotranslational protein targeting to membrane;viral transcription;SRP-dependent cotranslational protein targeting to membrane;nitrogen compound metabolic process;multi-organism metabolic process;ncRNA metabolic process;macromolecule metabolic process;ribosomal large subunit assembly;organic substance biosynthetic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;intracellular protein transport;ribosome assembly;ribosome biogenesis;cellular component organization;macromolecular complex assembly;organic cyclic compound metabolic process;heterocycle biosynthetic process;ribosomal large subunit biogenesis;transport;cellular protein complex disassembly;heterocycle catabolic process;aromatic compound catabolic process;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;nucleobase-containing compound catabolic process;establishment of localization;macromolecule biosynthetic process;cellular modified amino acid metabolic process;RNA metabolic process;mRNA metabolic process;rRNA metabolic process;cellular nitrogen compound biosynthetic process;cellular nitrogen compound catabolic process;intracellular transport;single-organism transport;protein targeting to ER;cellular amide metabolic process;single-organism membrane organization;peptide metabolic process;RNA biosynthetic process;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular macromolecule biosynthetic process;protein complex disassembly;organonitrogen compound biosynthetic process;single-organism process;nucleobase-containing compound metabolic process;protein localization to endoplasmic reticulum;localization;ribonucleoprotein complex assembly;ribonucleoprotein complex biogenesis;alpha-amino acid metabolic process;protein targeting to membrane;establishment of protein localization to endoplasmic reticulum;establishment of protein localization to organelle;cellular process;cellular aromatic compound metabolic process;translational initiation;amide biosynthetic process;macromolecule localization;organic acid metabolic process;selenocysteine metabolic process;nuclear-transcribed mRNA catabolic process;protein localization to organelle;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;macromolecular complex subunit organization;carboxylic acid metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;selenium compound metabolic process;serine family amino acid metabolic process;ribonucleoprotein complex subunit organization;protein complex subunit organization;cellular amino acid metabolic process;organic substance metabolic process;gene expression;organic substance transport;RNA catabolic process;mRNA catabolic process;cellular protein metabolic process;cellular protein localization;macromolecular complex disassembly;biosynthetic process;multi-organism cellular process;single-organism cellular process;establishment of localization in cell;organelle assembly;catabolic process;macromolecule catabolic process;single-organism localization;cellular localization;organelle organization;primary metabolic process;translational elongation;establishment of protein localization to membrane;cellular metabolic process;single-organism intracellular transport;cellular component biogenesis;viral process;protein transport;symbiosis, encompassing mutualism through parasitism;translational termination;single-organism cellular localization;cellular component disassembly;translation;RNA processing; 4;4;4;5;2;5;3;4;6;3;5;4;6;7;6;4;5;5;4;2;4;5;4;4;7;5;6;3;3;6;4;6;4;4;5;4;6;6;5;3;5;4;5;5;4;7;5;5;1;2;5;5;3;5;4;5;6;7;5;5;5;4;5;5;4;5;6;4;4;4;5;6;5;2;4;7;2;5;4;5;6;6;5;2;4;4;6;3;4;5;8;6;9;4;6;5;6;4;6;5;5;4;3;5;5;6;7;5;5;5;3;3;3;4;5;3;5;3;3;4;3;6;5;3;5;3;4;5;4;7;4;4;6;6; GO:0022626;GO:0022625;GO:0031974;GO:0031982;GO:0031981;GO:0016020;GO:0030054;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0044464;GO:0043229;GO:0005924;GO:0043227;GO:0043226;GO:0030055;GO:0070161;GO:0044446;GO:0044444;GO:0044445;GO:0015934;GO:1903561;GO:0005737;GO:0005730;GO:0005634;GO:0044391;GO:0005912;GO:0005840;GO:1990904;GO:0005623;GO:0005622;GO:0043228;GO:0005925;GO:0070062;GO:0070013;GO:0030529;GO:0005576;GO:0032991;GO:0005575; cytosolic ribosome;cytosolic large ribosomal subunit;membrane-enclosed lumen;vesicle;nuclear lumen;membrane;cell junction;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;extracellular region part;organelle part;cell part;intracellular organelle;cell-substrate adherens junction;membrane-bounded organelle;organelle;cell-substrate junction;anchoring junction;intracellular organelle part;cytoplasmic part;cytosolic part;large ribosomal subunit;extracellular vesicle;cytoplasm;nucleolus;nucleus;ribosomal subunit;adherens junction;ribosome;ribonucleoprotein complex;cell;intracellular;non-membrane-bounded organelle;focal adhesion;extracellular exosome;intracellular organelle lumen;intracellular ribonucleoprotein complex;extracellular region;macromolecular complex;cellular_component; 6;6;2;4;5;2;2;3;4;4;3;5;4;3;2;2;2;3;4;3;2;3;3;3;4;5;5;3;4;5;5;4;4;5;3;2;3;3;5;4;4;4;2;2;1; GO:0005198;GO:1901363;GO:0005488;GO:0003676;GO:0097159;GO:0044822;GO:0008097;GO:0003723;GO:0003674;GO:0003735;GO:0019843; structural molecule activity;heterocyclic compound binding;binding;nucleic acid binding;organic cyclic compound binding;poly(A) RNA binding;5S rRNA binding;RNA binding;molecular_function;structural constituent of ribosome;rRNA binding; 2;3;2;4;3;6;7;5;1;3;6; K02932 map03010; Ribosome; IPR025607;IPR005485; Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal;Ribosomal protein L5 eukaryotic/L18 archaeal; nucleus Hs14591909 617.0 J [J] Translation, ribosomal structure and biogenesis; Q9Y4D8 Probable E3 ubiquitin-protein ligase HECTD4 OS=Homo sapiens OX=9606 GN=HECTD4 PE=1 SV=5 - [HECD4_HUMAN] 0.616 1.336 1.416 0.638 1.123 0.829 0.461077844 nan 0.568121104 nan 1.05988024 nan 0.738201247 nan GO:0044238;GO:0042592;GO:0042593;GO:0044281;GO:0043632;GO:0043170;GO:0044723;GO:0044267;GO:1901575;GO:0044265;GO:0044260;GO:0032446;GO:0009056;GO:0070647;GO:0033500;GO:0071704;GO:0065007;GO:0044699;GO:0042787;GO:0065008;GO:0051603;GO:0019318;GO:0009987;GO:0019941;GO:0044710;GO:0006464;GO:0043412;GO:0036211;GO:0008150;GO:0030163;GO:0008152;GO:0006508;GO:0044257;GO:0009057;GO:0044248;GO:0005975;GO:0019538;GO:0005996;GO:0044237;GO:0048878;GO:0016567;GO:0006511;GO:0006006; primary metabolic process;homeostatic process;glucose homeostasis;small molecule metabolic process;modification-dependent macromolecule catabolic process;macromolecule metabolic process;single-organism carbohydrate metabolic process;cellular protein metabolic process;organic substance catabolic process;cellular macromolecule catabolic process;cellular macromolecule metabolic process;protein modification by small protein conjugation;catabolic process;protein modification by small protein conjugation or removal;carbohydrate homeostasis;organic substance metabolic process;biological regulation;single-organism process;protein ubiquitination involved in ubiquitin-dependent protein catabolic process;regulation of biological quality;proteolysis involved in cellular protein catabolic process;hexose metabolic process;cellular process;modification-dependent protein catabolic process;single-organism metabolic process;cellular protein modification process;macromolecule modification;protein modification process;biological_process;protein catabolic process;metabolic process;proteolysis;cellular protein catabolic process;macromolecule catabolic process;cellular catabolic process;carbohydrate metabolic process;protein metabolic process;monosaccharide metabolic process;cellular metabolic process;chemical homeostasis;protein ubiquitination;ubiquitin-dependent protein catabolic process;glucose metabolic process; 3;4;7;4;6;4;4;5;4;5;4;8;3;7;6;3;2;2;9;3;6;6;2;7;3;6;5;5;1;5;2;5;6;5;4;4;4;5;3;5;9;8;7; GO:0031224;GO:0016021;GO:0016020;GO:0005575;GO:0044425; intrinsic component of membrane;integral component of membrane;membrane;cellular_component;membrane part; 3;4;2;1;2; GO:0003674;GO:0019787;GO:0016740;GO:0004842;GO:0003824;GO:0016874; molecular_function;ubiquitin-like protein transferase activity;transferase activity;ubiquitin-protein transferase activity;catalytic activity;ligase activity; 1;4;3;5;2;3; K17849 IPR000569; HECT domain; plasma membrane Q9BY42 Protein RTF2 homolog OS=Homo sapiens OX=9606 GN=RTFDC1 PE=1 SV=3 - [RTF2_HUMAN] 1.1 1.05 0.668 1.017 1.183 1.84 1.047619048 nan 0.859678783 nan 0.636190476 nan 1.555367709 nan IPR027799;IPR006735; Replication termination factor 2, RING-finger;Replication termination factor 2; mitochondria Hs11421005 628.0 S [S] Function unknown; Q9H3P7 Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4 - [GCP60_HUMAN] 0.945 0.898 1.259 0.904 1.041 1.256 1.05233853 nan 0.868395773 nan 1.402004454 nan 1.206532181 nan GO:0044699;GO:1901576;GO:0044710;GO:0044711;GO:1901362;GO:0071704;GO:1901360;GO:0006629;GO:0006810;GO:0009058;GO:0008150;GO:0008152;GO:0051234;GO:0051179;GO:0008202;GO:0008610;GO:0044238;GO:0006694; single-organism process;organic substance biosynthetic process;single-organism metabolic process;single-organism biosynthetic process;organic cyclic compound biosynthetic process;organic substance metabolic process;organic cyclic compound metabolic process;lipid metabolic process;transport;biosynthetic process;biological_process;metabolic process;establishment of localization;localization;steroid metabolic process;lipid biosynthetic process;primary metabolic process;steroid biosynthetic process; 2;4;3;4;5;3;4;4;4;3;1;2;3;2;5;5;3;6; GO:0031224;GO:0043229;GO:0005739;GO:0000139;GO:0043227;GO:0043226;GO:0005737;GO:0031090;GO:0016021;GO:0016020;GO:0044431;GO:0005794;GO:0098588;GO:0044446;GO:0012505;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424;GO:0044425;GO:0044422; intrinsic component of membrane;intracellular organelle;mitochondrion;Golgi membrane;membrane-bounded organelle;organelle;cytoplasm;organelle membrane;integral component of membrane;membrane;Golgi apparatus part;Golgi apparatus;bounding membrane of organelle;intracellular organelle part;endomembrane system;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part;membrane part;organelle part; 3;3;5;5;3;2;4;3;4;2;4;4;4;3;3;4;2;2;3;1;4;3;2;2; GO:1901681;GO:0003674;GO:0005488;GO:0000062;GO:0043167;GO:0051018;GO:0050662;GO:0048037;GO:0005515;GO:0043168;GO:0034237; sulfur compound binding;molecular_function;binding;fatty-acyl-CoA binding;ion binding;protein kinase A binding;coenzyme binding;cofactor binding;protein binding;anion binding;protein kinase A regulatory subunit binding; 3;1;2;4;3;4;4;3;3;4;5; IPR009038;IPR000582;IPR022408;IPR014352; GOLD domain;Acyl-CoA-binding protein, ACBP;Acyl-CoA-binding protein, ACBP, conserved site;FERM/acyl-CoA-binding protein, 3-helical bundle; nucleus Hs15826852 1083.0 U [U] Intracellular trafficking, secretion, and vesicular transport; Q9UK55 Protein Z-dependent protease inhibitor OS=Homo sapiens OX=9606 GN=SERPINA10 PE=1 SV=1 - [ZPI_HUMAN] 1.031 0.994 0.949 1.079 1.035 0.667 1.03722334 0.74162639 1.042512077 0.521211846 0.95472837 0.660776252 0.644444444 0.608783034 GO:0007599;GO:0019222;GO:0007596;GO:0031324;GO:0045861;GO:0008152;GO:0050789;GO:0050790;GO:0009892;GO:0044699;GO:0080090;GO:0044267;GO:0051248;GO:0008218;GO:0010605;GO:0044260;GO:0051246;GO:0009611;GO:0043086;GO:0071704;GO:0010466;GO:0065007;GO:0044092;GO:0048519;GO:0065009;GO:0065008;GO:0032501;GO:0050878;GO:0052547;GO:0052548;GO:0031323;GO:0042060;GO:0050794;GO:0006950;GO:0050817;GO:0008150;GO:0010951;GO:0051346;GO:0006508;GO:0051336;GO:0044238;GO:0032269;GO:0032268;GO:0044707;GO:0060255;GO:0050896;GO:0044237;GO:0043170;GO:0019538;GO:0030162;GO:0009987;GO:0048523; hemostasis;regulation of metabolic process;blood coagulation;negative regulation of cellular metabolic process;negative regulation of proteolysis;metabolic process;regulation of biological process;regulation of catalytic activity;negative regulation of metabolic process;single-organism process;regulation of primary metabolic process;cellular protein metabolic process;negative regulation of protein metabolic process;bioluminescence;negative regulation of macromolecule metabolic process;cellular macromolecule metabolic process;regulation of protein metabolic process;response to wounding;negative regulation of catalytic activity;organic substance metabolic process;negative regulation of peptidase activity;biological regulation;negative regulation of molecular function;negative regulation of biological process;regulation of molecular function;regulation of biological quality;multicellular organismal process;regulation of body fluid levels;regulation of peptidase activity;regulation of endopeptidase activity;regulation of cellular metabolic process;wound healing;regulation of cellular process;response to stress;coagulation;biological_process;negative regulation of endopeptidase activity;negative regulation of hydrolase activity;proteolysis;regulation of hydrolase activity;primary metabolic process;negative regulation of cellular protein metabolic process;regulation of cellular protein metabolic process;single-multicellular organism process;regulation of macromolecule metabolic process;response to stimulus;cellular metabolic process;macromolecule metabolic process;protein metabolic process;regulation of proteolysis;cellular process;negative regulation of cellular process; 5;3;5;4;6;2;2;4;3;2;4;5;5;4;4;4;5;4;5;3;7;2;4;2;3;3;2;4;6;7;4;5;3;3;4;1;8;6;5;5;3;5;5;3;4;2;3;4;4;6;2;3; GO:0043227;GO:0043226;GO:0070062;GO:0005615;GO:1903561;GO:0031982;GO:0043230;GO:0005575;GO:0005576;GO:0044421; membrane-bounded organelle;organelle;extracellular exosome;extracellular space;extracellular vesicle;vesicle;extracellular organelle;cellular_component;extracellular region;extracellular region part; 3;2;4;3;3;4;3;1;2;2; GO:0030414;GO:0003674;GO:0005539;GO:0004857;GO:0098772;GO:0043168;GO:0097367;GO:0008201;GO:0061135;GO:1901681;GO:0030234;GO:0061134;GO:0004866;GO:0004867;GO:0043167;GO:0005488; peptidase inhibitor activity;molecular_function;glycosaminoglycan binding;enzyme inhibitor activity;molecular function regulator;anion binding;carbohydrate derivative binding;heparin binding;endopeptidase regulator activity;sulfur compound binding;enzyme regulator activity;peptidase regulator activity;endopeptidase inhibitor activity;serine-type endopeptidase inhibitor activity;ion binding;binding; 5;1;4;4;2;4;3;4;5;3;3;4;6;7;3;2; K04525 IPR000215;IPR023796;IPR033835; Serpin family;Serpin domain;Protein Z-dependent peptidase inhibitor; extracellular Hs7705879 916.0 V [V] Defense mechanisms; Q5H9R7 Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2 - [PP6R3_HUMAN] 0.657 0.832 1.866 0.829 0.628 1.655 0.789663462 nan 1.320063694 nan 2.242788462 nan 2.635350318 nan GO:0019220;GO:0080090;GO:0019222;GO:0006470;GO:0006901;GO:0006900;GO:0061024;GO:0051656;GO:0051650;GO:0071840;GO:0065003;GO:0044710;GO:0018193;GO:0060255;GO:0006903;GO:0051668;GO:0016192;GO:0019538;GO:0016050;GO:0022607;GO:0050789;GO:1901576;GO:0006888;GO:0044260;GO:0048193;GO:0016043;GO:0065007;GO:0065009;GO:0006810;GO:0050790;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0035303;GO:0051234;GO:0035304;GO:0051336;GO:0090114;GO:0043666;GO:0046907;GO:0044765;GO:0043413;GO:0044802;GO:0018196;GO:0070271;GO:0016311;GO:0010921;GO:0044249;GO:0034645;GO:0044699;GO:0051246;GO:0051640;GO:0031399;GO:1902591;GO:0043687;GO:0009987;GO:0032268;GO:1901137;GO:1901135;GO:0043170;GO:0048208;GO:0043933;GO:0031323;GO:0048207;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:1902589;GO:0071704;GO:0018279;GO:0044267;GO:0006461;GO:0070085;GO:0048199;GO:0006464;GO:0051174;GO:0009058;GO:0009059;GO:0044763;GO:0051648;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0005975;GO:0071822;GO:0044237;GO:0006796;GO:0044085;GO:0006793;GO:1902582;GO:1902580; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;protein dephosphorylation;vesicle coating;membrane budding;membrane organization;establishment of organelle localization;establishment of vesicle localization;cellular component organization or biogenesis;macromolecular complex assembly;single-organism metabolic process;peptidyl-amino acid modification;regulation of macromolecule metabolic process;vesicle targeting;localization within membrane;vesicle-mediated transport;protein metabolic process;vesicle organization;cellular component assembly;regulation of biological process;organic substance biosynthetic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;Golgi vesicle transport;cellular component organization;biological regulation;regulation of molecular function;transport;regulation of catalytic activity;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;regulation of dephosphorylation;establishment of localization;regulation of protein dephosphorylation;regulation of hydrolase activity;COPII-coated vesicle budding;regulation of phosphoprotein phosphatase activity;intracellular transport;single-organism transport;macromolecule glycosylation;single-organism membrane organization;peptidyl-asparagine modification;protein complex biogenesis;dephosphorylation;regulation of phosphatase activity;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;regulation of protein metabolic process;organelle localization;regulation of protein modification process;single-organism membrane budding;post-translational protein modification;cellular process;regulation of cellular protein metabolic process;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;COPII vesicle coating;macromolecular complex subunit organization;regulation of cellular metabolic process;vesicle targeting, rough ER to cis-Golgi;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;single-organism organelle organization;organic substance metabolic process;protein N-linked glycosylation via asparagine;cellular protein metabolic process;protein complex assembly;glycosylation;vesicle targeting, to, from or within Golgi;cellular protein modification process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;vesicle localization;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;carbohydrate metabolic process;protein complex subunit organization;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;phosphorus metabolic process;single-organism intracellular transport;single-organism cellular localization; 6;4;3;7;6;5;4;4;5;2;5;3;7;4;4;4;5;4;5;4;2;4;7;4;6;3;2;3;4;4;3;5;5;1;2;4;7;3;7;5;5;7;5;4;6;4;8;4;6;6;4;5;2;5;4;6;5;7;2;5;5;4;4;6;4;4;6;5;6;4;5;4;3;6;5;5;5;5;6;5;3;5;3;5;4;2;3;3;4;3;4;5;3;5;3;4;5;4; GO:0031974;GO:0031981;GO:0016020;GO:0005794;GO:0098588;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0044431;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0005886;GO:0005737;GO:0031090;GO:0005634;GO:0044464;GO:0005623;GO:0071944;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;nuclear lumen;membrane;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;Golgi apparatus part;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;plasma membrane;cytoplasm;organelle membrane;nucleus;cell part;cell;cell periphery;organelle;cellular_component;intracellular organelle lumen; 2;5;2;4;4;4;3;5;4;3;2;3;3;3;5;4;3;5;3;4;3;4;3;5;2;2;3;2;1;4; GO:0019903;GO:0019902;GO:0003674;GO:0005488;GO:0019899;GO:0005515; protein phosphatase binding;phosphatase binding;molecular_function;binding;enzyme binding;protein binding; 6;5;1;2;4;3; K15501 IPR007587;IPR016024;IPR011989; SIT4 phosphatase-associated protein family;Armadillo-type fold;Armadillo-like helical; nucleus Hs13489083 1593.0 D [D] Cell cycle control, cell division, chromosome partitioning; P28330 Long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADL PE=1 SV=2 - [ACADL_HUMAN] 1.055 0.853 1.082 1.186 0.856 1.59 1.236811254 nan 1.385514019 nan 1.268464244 nan 1.857476636 nan GO:0034440;GO:0080090;GO:0019222;GO:0051289;GO:0042758;GO:0044281;GO:0044282;GO:0001659;GO:1901360;GO:0044712;GO:0044710;GO:0044711;GO:0045833;GO:0048519;GO:0051055;GO:0032787;GO:1902652;GO:0072329;GO:0043436;GO:0055114;GO:1901565;GO:1901564;GO:0044707;GO:0006579;GO:0016054;GO:0006577;GO:0016053;GO:0048878;GO:0022607;GO:0009892;GO:0009890;GO:0044283;GO:0090181;GO:0009062;GO:0046322;GO:0050789;GO:1901576;GO:1901575;GO:0097164;GO:0016043;GO:0016042;GO:0065003;GO:0065007;GO:0071840;GO:0065008;GO:0006629;GO:0009889;GO:0050794;GO:0008150;GO:0008152;GO:0001676;GO:0019395;GO:0042304;GO:0044270;GO:0046394;GO:0046395;GO:0045717;GO:1901616;GO:1901615;GO:0006633;GO:0006631;GO:0006635;GO:0070271;GO:0044248;GO:0044249;GO:0034641;GO:0044242;GO:0044699;GO:0010565;GO:0031327;GO:0019254;GO:0008610;GO:0016125;GO:0032501;GO:0009987;GO:0055088;GO:0044255;GO:0030258;GO:0008202;GO:0008203;GO:0051259;GO:0006082;GO:0046320;GO:0048871;GO:0072330;GO:0006807;GO:0045922;GO:0043933;GO:0031326;GO:0031324;GO:0031323;GO:0019752;GO:0042592;GO:0009437;GO:0046890;GO:0006066;GO:0071822;GO:0051260;GO:0051262;GO:0071704;GO:0019217;GO:0019216;GO:0019218;GO:0006461;GO:0009058;GO:0044763;GO:0009056;GO:0044238;GO:0042180;GO:0033539;GO:0044237;GO:0044085;GO:0042413;GO:0048523; lipid oxidation;regulation of primary metabolic process;regulation of metabolic process;protein homotetramerization;long-chain fatty acid catabolic process;small molecule metabolic process;small molecule catabolic process;temperature homeostasis;organic cyclic compound metabolic process;single-organism catabolic process;single-organism metabolic process;single-organism biosynthetic process;negative regulation of lipid metabolic process;negative regulation of biological process;negative regulation of lipid biosynthetic process;monocarboxylic acid metabolic process;secondary alcohol metabolic process;monocarboxylic acid catabolic process;oxoacid metabolic process;oxidation-reduction process;organonitrogen compound catabolic process;organonitrogen compound metabolic process;single-multicellular organism process;amino-acid betaine catabolic process;organic acid catabolic process;amino-acid betaine metabolic process;organic acid biosynthetic process;chemical homeostasis;cellular component assembly;negative regulation of metabolic process;negative regulation of biosynthetic process;small molecule biosynthetic process;regulation of cholesterol metabolic process;fatty acid catabolic process;negative regulation of fatty acid oxidation;regulation of biological process;organic substance biosynthetic process;organic substance catabolic process;ammonium ion metabolic process;cellular component organization;lipid catabolic process;macromolecular complex assembly;biological regulation;cellular component organization or biogenesis;regulation of biological quality;lipid metabolic process;regulation of biosynthetic process;regulation of cellular process;biological_process;metabolic process;long-chain fatty acid metabolic process;fatty acid oxidation;regulation of fatty acid biosynthetic process;cellular nitrogen compound catabolic process;carboxylic acid biosynthetic process;carboxylic acid catabolic process;negative regulation of fatty acid biosynthetic process;organic hydroxy compound catabolic process;organic hydroxy compound metabolic process;fatty acid biosynthetic process;fatty acid metabolic process;fatty acid beta-oxidation;protein complex biogenesis;cellular catabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;cellular lipid catabolic process;single-organism process;regulation of cellular ketone metabolic process;negative regulation of cellular biosynthetic process;carnitine metabolic process, CoA-linked;lipid biosynthetic process;sterol metabolic process;multicellular organismal process;cellular process;lipid homeostasis;cellular lipid metabolic process;lipid modification;steroid metabolic process;cholesterol metabolic process;protein oligomerization;organic acid metabolic process;regulation of fatty acid oxidation;multicellular organismal homeostasis;monocarboxylic acid biosynthetic process;nitrogen compound metabolic process;negative regulation of fatty acid metabolic process;macromolecular complex subunit organization;regulation of cellular biosynthetic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;homeostatic process;carnitine metabolic process;regulation of lipid biosynthetic process;alcohol metabolic process;protein complex subunit organization;protein homooligomerization;protein tetramerization;organic substance metabolic process;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of steroid metabolic process;protein complex assembly;biosynthetic process;single-organism cellular process;catabolic process;primary metabolic process;cellular ketone metabolic process;fatty acid beta-oxidation using acyl-CoA dehydrogenase;cellular metabolic process;cellular component biogenesis;carnitine catabolic process;negative regulation of cellular process; 5;4;3;8;7;4;5;5;4;4;3;4;4;2;5;7;6;7;5;4;5;4;3;6;5;5;5;5;4;3;4;5;7;6;6;2;4;4;4;3;5;5;2;2;3;4;4;3;1;2;6;6;6;5;6;6;6;5;4;6;5;7;4;4;4;4;5;2;5;5;6;5;6;2;2;6;4;5;5;7;6;4;7;4;7;3;5;4;5;4;4;6;4;5;5;5;5;7;7;3;6;5;6;5;3;3;3;3;4;8;3;3;6;3; GO:0031974;GO:0031975;GO:0016020;GO:0031967;GO:0043231;GO:0043233;GO:0044429;GO:0044424;GO:0044422;GO:0043229;GO:0043227;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005739;GO:0005759;GO:0044464;GO:0005623;GO:0005622;GO:0005740;GO:0043226;GO:0031966;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;membrane;organelle envelope;intracellular membrane-bounded organelle;organelle lumen;mitochondrial part;intracellular part;organelle part;intracellular organelle;membrane-bounded organelle;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;mitochondrion;mitochondrial matrix;cell part;cell;intracellular;mitochondrial envelope;organelle;mitochondrial membrane;cellular_component;intracellular organelle lumen; 2;3;2;4;4;3;4;3;2;3;3;3;4;4;3;5;5;2;2;3;5;2;4;1;4; GO:1901363;GO:0016627;GO:0000166;GO:0003997;GO:0003674;GO:0005488;GO:1901265;GO:0043168;GO:0052890;GO:0003824;GO:0016491;GO:0050662;GO:0043167;GO:0048037;GO:0003995;GO:0016401;GO:0097159;GO:1901681;GO:0050660;GO:0004466;GO:0000062;GO:0036094;GO:0009055;GO:0016634; heterocyclic compound binding;oxidoreductase activity, acting on the CH-CH group of donors;nucleotide binding;acyl-CoA oxidase activity;molecular_function;binding;nucleoside phosphate binding;anion binding;oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor;catalytic activity;oxidoreductase activity;coenzyme binding;ion binding;cofactor binding;acyl-CoA dehydrogenase activity;palmitoyl-CoA oxidase activity;organic cyclic compound binding;sulfur compound binding;flavin adenine dinucleotide binding;long-chain-acyl-CoA dehydrogenase activity;fatty-acyl-CoA binding;small molecule binding;electron carrier activity;oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor; 3;4;4;6;1;2;4;4;5;2;3;4;3;3;5;7;3;3;5;6;4;3;2;5; K00255 map00071;map01100;map01212;map03320; Fatty acid degradation;Metabolic pathways;Fatty acid metabolism;PPAR signaling pathway; IPR009075;IPR006089;IPR013786;IPR009100;IPR006091;IPR034179; Acyl-CoA dehydrogenase/oxidase C-terminal;Acyl-CoA dehydrogenase, conserved site;Acyl-CoA dehydrogenase/oxidase, N-terminal;Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain;Acyl-CoA oxidase/dehydrogenase, central domain;Long-chain specific acyl-CoA dehydrogenase; mitochondria Hs4501857 893.0 EI [E] Amino acid transport and metabolism;[I] Lipid transport and metabolism; P08294 Extracellular superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD3 PE=1 SV=2 - [SODE_HUMAN] 0.893 0.946 1.075 1.046 1.202 1.102 0.94397463 nan 0.870216306 nan 1.136363636 nan 0.916805324 nan GO:0010035;GO:1990267;GO:0000302;GO:0001666;GO:0046688;GO:0006950;GO:0008150;GO:0010038;GO:0042221;GO:0006979;GO:0070482;GO:1901700;GO:0009628;GO:0036293;GO:0050896; response to inorganic substance;response to transition metal nanoparticle;response to reactive oxygen species;response to hypoxia;response to copper ion;response to stress;biological_process;response to metal ion;response to chemical;response to oxidative stress;response to oxygen levels;response to oxygen-containing compound;response to abiotic stimulus;response to decreased oxygen levels;response to stimulus; 4;4;5;4;5;3;1;5;3;4;4;4;3;5;2; GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0044446;GO:0031984;GO:0005615;GO:1903561;GO:0005634;GO:0070062;GO:0044431;GO:0005794;GO:0005796;GO:0031982;GO:0012505;GO:0031012;GO:0043230;GO:0043231;GO:0043233;GO:0005802;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0070013;GO:0044444;GO:0005576;GO:0098791;GO:0044424;GO:0044421;GO:0044422; membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;intracellular organelle part;organelle subcompartment;extracellular space;extracellular vesicle;nucleus;extracellular exosome;Golgi apparatus part;Golgi apparatus;Golgi lumen;vesicle;endomembrane system;extracellular matrix;extracellular organelle;intracellular membrane-bounded organelle;organelle lumen;trans-Golgi network;cell part;cell;intracellular;cellular_component;intracellular organelle lumen;cytoplasmic part;extracellular region;Golgi subcompartment;intracellular part;extracellular region part;organelle part; 2;3;3;2;4;3;4;3;3;5;4;4;4;5;4;3;2;3;4;3;5;2;2;3;1;4;4;2;5;3;2;2; GO:0043168;GO:0016721;GO:0005539;GO:0003674;GO:0005488;GO:0004784;GO:0016491;GO:0046914;GO:0043167;GO:0046872;GO:0043169;GO:0016209;GO:0003824;GO:0005507;GO:0008201;GO:0097367;GO:1901681;GO:0008270; anion binding;oxidoreductase activity, acting on superoxide radicals as acceptor;glycosaminoglycan binding;molecular_function;binding;superoxide dismutase activity;oxidoreductase activity;transition metal ion binding;ion binding;metal ion binding;cation binding;antioxidant activity;catalytic activity;copper ion binding;heparin binding;carbohydrate derivative binding;sulfur compound binding;zinc ion binding; 4;4;4;1;2;3;3;6;3;5;4;2;2;7;4;3;3;7; K16627 IPR001424;IPR018152; Superoxide dismutase, copper/zinc binding domain;Superoxide dismutase, copper/zinc, binding site; extracellular Hs4507151 491.0 P [P] Inorganic ion transport and metabolism; O15504 Nucleoporin-like protein 2 OS=Homo sapiens OX=9606 GN=NUPL2 PE=1 SV=1 - [NUPL2_HUMAN] 1.109 1.096 0.855 1.177 1.052 0.866 1.011861314 nan 1.118821293 nan 0.780109489 nan 0.823193916 nan GO:0051169;GO:0008104;GO:0019221;GO:0019222;GO:0051049;GO:0034605;GO:0043412;GO:0048583;GO:0061024;GO:0051168;GO:0007165;GO:0007166;GO:1901362;GO:1901360;GO:0071705;GO:0051716;GO:0016925;GO:0010605;GO:0070727;GO:0071840;GO:0010256;GO:0071310;GO:0018193;GO:0044419;GO:0032446;GO:0016458;GO:0019058;GO:0051817;GO:0048519;GO:0033036;GO:0019054;GO:0034470;GO:0060255;GO:0045184;GO:0007077;GO:0051701;GO:0010033;GO:0051704;GO:0044700;GO:0019538;GO:0046483;GO:0018205;GO:0033554;GO:0019438;GO:0044281;GO:0009892;GO:0006611;GO:0044068;GO:0019083;GO:0006997;GO:0006807;GO:0044033;GO:0034660;GO:0051028;GO:0050789;GO:0000278;GO:1901576;GO:0044260;GO:0008645;GO:0006886;GO:0016043;GO:0008643;GO:0065007;GO:0007049;GO:0065008;GO:0018130;GO:0034097;GO:0006810;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0009266;GO:0034654;GO:0051236;GO:0051234;GO:0016070;GO:0050658;GO:0044271;GO:0046907;GO:0071345;GO:0050896;GO:0080135;GO:0044765;GO:0009059;GO:0044802;GO:0015931;GO:0032774;GO:0070647;GO:0044249;GO:0034641;GO:0023052;GO:0070887;GO:0007154;GO:0044699;GO:0006139;GO:0051081;GO:0044003;GO:0019080;GO:0008033;GO:0044238;GO:0043687;GO:0009987;GO:0006725;GO:0009408;GO:0032879;GO:0055085;GO:0030397;GO:1902582;GO:1900034;GO:0010629;GO:0043170;GO:0080134;GO:0019048;GO:1903047;GO:0050657;GO:0090304;GO:0010827;GO:0022402;GO:0006998;GO:0006399;GO:0010468;GO:0015758;GO:0071704;GO:0010467;GO:0071702;GO:0006403;GO:0015749;GO:0044267;GO:0034613;GO:0006913;GO:0006464;GO:0009058;GO:0044764;GO:0044763;GO:0031047;GO:0051649;GO:0042221;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0009628;GO:0005975;GO:0044237;GO:0016032;GO:0015031;GO:0044403;GO:0022411;GO:0035821;GO:0006396; nuclear transport;protein localization;cytokine-mediated signaling pathway;regulation of metabolic process;regulation of transport;cellular response to heat;macromolecule modification;regulation of response to stimulus;membrane organization;nuclear export;signal transduction;cell surface receptor signaling pathway;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;nitrogen compound transport;cellular response to stimulus;protein sumoylation;negative regulation of macromolecule metabolic process;cellular macromolecule localization;cellular component organization or biogenesis;endomembrane system organization;cellular response to organic substance;peptidyl-amino acid modification;interspecies interaction between organisms;protein modification by small protein conjugation;gene silencing;viral life cycle;modification of morphology or physiology of other organism involved in symbiotic interaction;negative regulation of biological process;macromolecule localization;modulation by virus of host process;ncRNA processing;regulation of macromolecule metabolic process;establishment of protein localization;mitotic nuclear envelope disassembly;interaction with host;response to organic substance;multi-organism process;single organism signaling;protein metabolic process;heterocycle metabolic process;peptidyl-lysine modification;cellular response to stress;aromatic compound biosynthetic process;small molecule metabolic process;negative regulation of metabolic process;protein export from nucleus;modulation by symbiont of host cellular process;viral transcription;nucleus organization;nitrogen compound metabolic process;multi-organism metabolic process;ncRNA metabolic process;mRNA transport;regulation of biological process;mitotic cell cycle;organic substance biosynthetic process;cellular macromolecule metabolic process;hexose transport;intracellular protein transport;cellular component organization;carbohydrate transport;biological regulation;cell cycle;regulation of biological quality;heterocycle biosynthetic process;response to cytokine;transport;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;response to temperature stimulus;nucleobase-containing compound biosynthetic process;establishment of RNA localization;establishment of localization;RNA metabolic process;RNA transport;cellular nitrogen compound biosynthetic process;intracellular transport;cellular response to cytokine stimulus;response to stimulus;regulation of cellular response to stress;single-organism transport;macromolecule biosynthetic process;single-organism membrane organization;nucleobase-containing compound transport;RNA biosynthetic process;protein modification by small protein conjugation or removal;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular response to chemical stimulus;cell communication;single-organism process;nucleobase-containing compound metabolic process;nuclear envelope disassembly;modification by symbiont of host morphology or physiology;viral gene expression;tRNA processing;primary metabolic process;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;response to heat;regulation of localization;transmembrane transport;membrane disassembly;single-organism intracellular transport;regulation of cellular response to heat;negative regulation of gene expression;macromolecule metabolic process;regulation of response to stress;modulation by virus of host morphology or physiology;mitotic cell cycle process;nucleic acid transport;nucleic acid metabolic process;regulation of glucose transport;cell cycle process;nuclear envelope organization;tRNA metabolic process;regulation of gene expression;glucose transport;organic substance metabolic process;gene expression;organic substance transport;RNA localization;monosaccharide transport;cellular protein metabolic process;cellular protein localization;nucleocytoplasmic transport;cellular protein modification process;biosynthetic process;multi-organism cellular process;single-organism cellular process;gene silencing by RNA;establishment of localization in cell;response to chemical;localization;single-organism localization;cellular localization;organelle organization;response to abiotic stimulus;carbohydrate metabolic process;cellular metabolic process;viral process;protein transport;symbiosis, encompassing mutualism through parasitism;cellular component disassembly;modification of morphology or physiology of other organism;RNA processing; 6;4;6;3;4;5;5;3;4;8;4;5;5;4;5;3;9;4;4;2;4;5;7;3;8;4;5;4;2;3;5;7;4;4;6;4;4;2;3;4;4;8;4;5;4;3;6;4;5;5;3;3;6;6;2;5;4;4;7;6;3;5;2;4;3;5;5;4;3;3;3;5;1;2;4;5;4;3;5;5;5;5;6;2;4;4;5;4;6;6;7;4;4;2;4;4;2;4;6;5;4;8;3;7;2;4;4;3;4;5;5;5;5;4;4;5;5;7;5;5;4;5;7;5;8;3;5;5;4;6;5;5;7;6;3;3;3;5;4;3;2;3;3;4;3;4;3;4;5;4;4;3;6; GO:0031974;GO:0031975;GO:0031981;GO:0016020;GO:0031965;GO:0031967;GO:0043231;GO:0043233;GO:0005829;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0012505;GO:0044446;GO:0044444;GO:0005737;GO:0031090;GO:0005634;GO:0005635;GO:0044464;GO:0005623;GO:0005643;GO:0043226;GO:0005575;GO:0070013; membrane-enclosed lumen;envelope;nuclear lumen;membrane;nuclear membrane;organelle envelope;intracellular membrane-bounded organelle;organelle lumen;cytosol;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;endomembrane system;intracellular organelle part;cytoplasmic part;cytoplasm;organelle membrane;nucleus;nuclear envelope;cell part;cell;nuclear pore;organelle;cellular_component;intracellular organelle lumen; 2;3;5;2;4;4;4;3;5;4;3;2;3;3;3;5;3;3;4;4;3;5;4;2;2;5;2;1;4; GO:0005049;GO:1901363;GO:0005488;GO:0003676;GO:0008565;GO:0043169;GO:0022892;GO:0097159;GO:0043167;GO:0005215;GO:0003723;GO:0003674;GO:0005487;GO:0044822;GO:0046872; nuclear export signal receptor activity;heterocyclic compound binding;binding;nucleic acid binding;protein transporter activity;cation binding;substrate-specific transporter activity;organic cyclic compound binding;ion binding;transporter activity;RNA binding;molecular_function;nucleocytoplasmic transporter activity;poly(A) RNA binding;metal ion binding; 4;3;2;4;4;4;3;3;3;2;5;1;3;6;5; K14321 map03013; RNA transport; IPR000571; Zinc finger, CCCH-type; nucleus P27169 Serum paraoxonase/arylesterase 1 OS=Homo sapiens OX=9606 GN=PON1 PE=1 SV=3 - [PON1_HUMAN] 0.939 1.196 0.806 0.961 1.184 0.733 0.785117057 2.52E-52 0.811655405 1.67E-43 0.673913043 1.19E-19 0.619087838 0.000697483 GO:0051049;GO:0044281;GO:0044282;GO:1901360;GO:0046434;GO:0044712;GO:0044710;GO:0044093;GO:0048518;GO:0051050;GO:0019439;GO:0006869;GO:1902652;GO:0043436;GO:1901564;GO:0046486;GO:0010035;GO:0010876;GO:0010033;GO:0010874;GO:0010875;GO:0044248;GO:0009605;GO:0016054;GO:0031667;GO:0019637;GO:0032411;GO:0015918;GO:0015850;GO:0006807;GO:1901575;GO:0097164;GO:0065007;GO:0065009;GO:0006629;GO:0009308;GO:0006810;GO:0008150;GO:0008152;GO:0051234;GO:0032368;GO:0046395;GO:0050896;GO:0042439;GO:0006576;GO:1901615;GO:0030301;GO:0034641;GO:0044699;GO:0032374;GO:0032376;GO:0032371;GO:0032370;GO:0032373;GO:0032409;GO:0006644;GO:0016125;GO:0044238;GO:1902617;GO:0009987;GO:0006725;GO:0044106;GO:0001101;GO:0044255;GO:0032879;GO:0008202;GO:0008203;GO:0033036;GO:0006082;GO:0070542;GO:0051098;GO:0046470;GO:0009991;GO:0006650;GO:0019752;GO:0006066;GO:0033993;GO:0009636;GO:0050789;GO:0071704;GO:0071702;GO:0044765;GO:0044763;GO:0042221;GO:0009056;GO:0051179;GO:1902578;GO:1901700;GO:0051099;GO:0044237;GO:0006796;GO:0033344;GO:0006793; regulation of transport;small molecule metabolic process;small molecule catabolic process;organic cyclic compound metabolic process;organophosphate catabolic process;single-organism catabolic process;single-organism metabolic process;positive regulation of molecular function;positive regulation of biological process;positive regulation of transport;aromatic compound catabolic process;lipid transport;secondary alcohol metabolic process;oxoacid metabolic process;organonitrogen compound metabolic process;glycerolipid metabolic process;response to inorganic substance;lipid localization;response to organic substance;regulation of cholesterol efflux;positive regulation of cholesterol efflux;cellular catabolic process;response to external stimulus;organic acid catabolic process;response to nutrient levels;organophosphate metabolic process;positive regulation of transporter activity;sterol transport;organic hydroxy compound transport;nitrogen compound metabolic process;organic substance catabolic process;ammonium ion metabolic process;biological regulation;regulation of molecular function;lipid metabolic process;amine metabolic process;transport;biological_process;metabolic process;establishment of localization;regulation of lipid transport;carboxylic acid catabolic process;response to stimulus;ethanolamine-containing compound metabolic process;cellular biogenic amine metabolic process;organic hydroxy compound metabolic process;cholesterol transport;cellular nitrogen compound metabolic process;single-organism process;regulation of cholesterol transport;positive regulation of cholesterol transport;regulation of sterol transport;positive regulation of lipid transport;positive regulation of sterol transport;regulation of transporter activity;phospholipid metabolic process;sterol metabolic process;primary metabolic process;response to fluoride;cellular process;cellular aromatic compound metabolic process;cellular amine metabolic process;response to acid chemical;cellular lipid metabolic process;regulation of localization;steroid metabolic process;cholesterol metabolic process;macromolecule localization;organic acid metabolic process;response to fatty acid;regulation of binding;phosphatidylcholine metabolic process;response to extracellular stimulus;glycerophospholipid metabolic process;carboxylic acid metabolic process;alcohol metabolic process;response to lipid;response to toxic substance;regulation of biological process;organic substance metabolic process;organic substance transport;single-organism transport;single-organism cellular process;response to chemical;catabolic process;localization;single-organism localization;response to oxygen-containing compound;positive regulation of binding;cellular metabolic process;phosphate-containing compound metabolic process;cholesterol efflux;phosphorus metabolic process; 4;4;5;4;5;4;3;4;2;3;5;5;6;5;4;5;4;4;4;8;7;4;3;5;5;4;4;6;5;3;4;4;2;3;4;5;4;1;2;3;5;6;2;4;6;4;7;4;2;7;6;6;4;5;4;5;6;3;5;2;4;5;4;4;3;5;7;3;4;5;4;5;4;6;6;5;5;4;2;3;5;4;3;3;3;2;3;4;5;3;5;8;4; GO:0034358;GO:0031982;GO:0034364;GO:0034366;GO:0043230;GO:0043231;GO:0044421;GO:0043229;GO:0043227;GO:0043226;GO:0072562;GO:1990777;GO:0044464;GO:0005623;GO:0005622;GO:0044424;GO:0005615;GO:0005576;GO:1903561;GO:0070062;GO:0032994;GO:0032991;GO:0005575; plasma lipoprotein particle;vesicle;high-density lipoprotein particle;spherical high-density lipoprotein particle;extracellular organelle;intracellular membrane-bounded organelle;extracellular region part;intracellular organelle;membrane-bounded organelle;organelle;blood microparticle;lipoprotein particle;cell part;cell;intracellular;intracellular part;extracellular space;extracellular region;extracellular vesicle;extracellular exosome;protein-lipid complex;macromolecular complex;cellular_component; 3;4;4;5;3;4;2;3;3;2;3;4;2;2;3;3;3;2;3;4;3;2;1; GO:0005543;GO:0046872;GO:0003674;GO:0005488;GO:0016787;GO:0016788;GO:0003824;GO:0046983;GO:0016791;GO:0046573;GO:0042578;GO:0043168;GO:0043169;GO:0043167;GO:0005509;GO:0102007;GO:0042802;GO:0042803;GO:0008289;GO:0052689;GO:0005515;GO:0004063;GO:0004064; phospholipid binding;metal ion binding;molecular_function;binding;hydrolase activity;hydrolase activity, acting on ester bonds;catalytic activity;protein dimerization activity;phosphatase activity;lactonohydrolase activity;phosphoric ester hydrolase activity;anion binding;cation binding;ion binding;calcium ion binding;acyl-L-homoserine-lactone lactonohydrolase activity;identical protein binding;protein homodimerization activity;lipid binding;carboxylic ester hydrolase activity;protein binding;aryldialkylphosphatase activity;arylesterase activity; 4;5;1;2;3;4;2;4;6;6;5;4;4;3;6;7;4;5;3;5;3;7;6; K01045 map00363;map00627;map01100;map01120; Bisphenol degradation;Aminobenzoate degradation;Metabolic pathways;Microbial metabolism in diverse environments; IPR008363;IPR011042;IPR002640; Paraoxonase1;Six-bladed beta-propeller, TolB-like;Arylesterase; extracellular 408672124 144.0 G [G] Carbohydrate transport and metabolism; COG3386 Sugar lactone lactonase YvrE P62685 Endogenous retrovirus group K member 8 Gag polyprotein OS=Homo sapiens OX=9606 GN=ERVK-8 PE=1 SV=2 - [GAK8_HUMAN] 0.823 1.067 0.662 1.871 1.043 0.935 0.771321462 nan 1.793863854 nan 0.620431115 nan 0.896452541 nan GO:0044419;GO:0009987;GO:0044764;GO:0008150;GO:0051704;GO:0016032;GO:0044403; interspecies interaction between organisms;cellular process;multi-organism cellular process;biological_process;multi-organism process;viral process;symbiosis, encompassing mutualism through parasitism; 3;2;3;1;2;4;4; GO:0071944;GO:0016020;GO:0019012;GO:0019028;GO:0005886;GO:0044464;GO:0005623;GO:0005575;GO:0044423; cell periphery;membrane;virion;viral capsid;plasma membrane;cell part;cell;cellular_component;virion part; 3;2;2;3;3;2;2;1;2; GO:0003674;GO:0008270;GO:0003676;GO:0043167;GO:1901363;GO:0043169;GO:0046914;GO:0005198;GO:0046872;GO:0097159;GO:0005488; molecular_function;zinc ion binding;nucleic acid binding;ion binding;heterocyclic compound binding;cation binding;transition metal ion binding;structural molecule activity;metal ion binding;organic cyclic compound binding;binding; 1;7;4;3;3;4;6;2;5;3;2; IPR000721;IPR008919;IPR008916;IPR003322;IPR010999;IPR001878; Retroviral nucleocapsid protein Gag;Retrovirus capsid, N-terminal domain;Retrovirus capsid, C-terminal;Beta-retroviral matrix protein;Retroviral matrix protein;Zinc finger, CCHC-type; cytosol Hs22057093_1 61.2 R [R] General function prediction only; Q9H3U1 Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1 - [UN45A_HUMAN] 0.964 0.823 0.589 0.81 0.84 5.229 1.171324423 nan 0.964285714 nan 0.715674362 nan 6.225 nan GO:0006457;GO:0030154;GO:0061061;GO:0044699;GO:0007517;GO:0048869;GO:0007275;GO:0048513;GO:0032502;GO:0032501;GO:0009987;GO:0044767;GO:0008150;GO:0061077;GO:0044707;GO:0048856;GO:0044763;GO:0048731; protein folding;cell differentiation;muscle structure development;single-organism process;muscle organ development;cellular developmental process;multicellular organism development;animal organ development;developmental process;multicellular organismal process;cellular process;single-organism developmental process;biological_process;chaperone-mediated protein folding;single-multicellular organism process;anatomical structure development;single-organism cellular process;system development; 3;5;4;2;5;4;4;4;2;2;2;3;1;4;3;3;3;4; GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005634;GO:0048471;GO:0043231;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0044444;GO:0044424; intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;nucleus;perinuclear region of cytoplasm;intracellular membrane-bounded organelle;cell part;cell;intracellular;cellular_component;cytoplasmic part;intracellular part; 3;3;2;4;5;5;4;2;2;3;1;4;3; K21991 IPR019734;IPR016024;IPR024660;IPR011990;IPR013026;IPR011989; Tetratricopeptide repeat;Armadillo-type fold;UNC-45/Cro1/She4, central domain;Tetratricopeptide-like helical domain;Tetratricopeptide repeat-containing domain;Armadillo-like helical; cytosol Hs18587044 727.0 ODR [O] Posttranslational modification, protein turnover, chaperones;[D] Cell cycle control, cell division, chromosome partitioning;[R] General function prediction only; P22692 Insulin-like growth factor-binding protein 4 OS=Homo sapiens OX=9606 GN=IGFBP4 PE=1 SV=2 - [IBP4_HUMAN] 0.671 0.925 1.629 1.095 0.826 1.264 0.725405405 0.265991854 1.32566586 0.289221307 1.761081081 0.255501128 1.530266344 0.104258288 GO:0019220;GO:0080090;GO:0019222;GO:0048585;GO:0048584;GO:0048583;GO:0001501;GO:0030111;GO:0007165;GO:0007166;GO:0007167;GO:0007169;GO:0071840;GO:0051716;GO:0010604;GO:0009968;GO:0009966;GO:0009967;GO:0000165;GO:0048518;GO:0048519;GO:0060255;GO:0006952;GO:0046483;GO:0042325;GO:0044700;GO:0042327;GO:0044707;GO:0019538;GO:0016055;GO:0043568;GO:0060828;GO:0044281;GO:0009893;GO:0010906;GO:0048009;GO:0035556;GO:0043170;GO:0050789;GO:0044267;GO:0016049;GO:0044260;GO:0044342;GO:0016043;GO:0065007;GO:0023014;GO:0019318;GO:0044710;GO:0050794;GO:0043410;GO:0060070;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:1902533;GO:1902531;GO:0006006;GO:0044767;GO:0050896;GO:0031401;GO:0006950;GO:0006109;GO:0006954;GO:0016310;GO:0051128;GO:0023056;GO:0023057;GO:0034641;GO:0044262;GO:0023052;GO:0010648;GO:0023051;GO:0010647;GO:0010646;GO:0044699;GO:0043408;GO:0006139;GO:0043567;GO:0010562;GO:0051246;GO:0051247;GO:0032270;GO:0031399;GO:0032502;GO:0032501;GO:0008283;GO:0009987;GO:0006725;GO:0001558;GO:0010675;GO:0005975;GO:0032268;GO:0005996;GO:0050673;GO:0006807;GO:0048731;GO:1901360;GO:0031325;GO:0031323;GO:0090304;GO:0007275;GO:0040008;GO:0030178;GO:0071704;GO:0090090;GO:0006468;GO:0045937;GO:0006464;GO:0051174;GO:0044763;GO:0007154;GO:0040007;GO:0044238;GO:0048856;GO:0044237;GO:0006796;GO:0006793;GO:0006259;GO:0001932;GO:0001934;GO:0048523;GO:0048522; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;negative regulation of response to stimulus;positive regulation of response to stimulus;regulation of response to stimulus;skeletal system development;regulation of Wnt signaling pathway;signal transduction;cell surface receptor signaling pathway;enzyme linked receptor protein signaling pathway;transmembrane receptor protein tyrosine kinase signaling pathway;cellular component organization or biogenesis;cellular response to stimulus;positive regulation of macromolecule metabolic process;negative regulation of signal transduction;regulation of signal transduction;positive regulation of signal transduction;MAPK cascade;positive regulation of biological process;negative regulation of biological process;regulation of macromolecule metabolic process;defense response;heterocycle metabolic process;regulation of phosphorylation;single organism signaling;positive regulation of phosphorylation;single-multicellular organism process;protein metabolic process;Wnt signaling pathway;positive regulation of insulin-like growth factor receptor signaling pathway;regulation of canonical Wnt signaling pathway;small molecule metabolic process;positive regulation of metabolic process;regulation of glucose metabolic process;insulin-like growth factor receptor signaling pathway;intracellular signal transduction;macromolecule metabolic process;regulation of biological process;cellular protein metabolic process;cell growth;cellular macromolecule metabolic process;type B pancreatic cell proliferation;cellular component organization;biological regulation;signal transduction by protein phosphorylation;hexose metabolic process;single-organism metabolic process;regulation of cellular process;positive regulation of MAPK cascade;canonical Wnt signaling pathway;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;positive regulation of intracellular signal transduction;regulation of intracellular signal transduction;glucose metabolic process;single-organism developmental process;response to stimulus;positive regulation of protein modification process;response to stress;regulation of carbohydrate metabolic process;inflammatory response;phosphorylation;regulation of cellular component organization;positive regulation of signaling;negative regulation of signaling;cellular nitrogen compound metabolic process;cellular carbohydrate metabolic process;signaling;negative regulation of cell communication;regulation of signaling;positive regulation of cell communication;regulation of cell communication;single-organism process;regulation of MAPK cascade;nucleobase-containing compound metabolic process;regulation of insulin-like growth factor receptor signaling pathway;positive regulation of phosphorus metabolic process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;regulation of protein modification process;developmental process;multicellular organismal process;cell proliferation;cellular process;cellular aromatic compound metabolic process;regulation of cell growth;regulation of cellular carbohydrate metabolic process;carbohydrate metabolic process;regulation of cellular protein metabolic process;monosaccharide metabolic process;epithelial cell proliferation;nitrogen compound metabolic process;system development;organic cyclic compound metabolic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;multicellular organism development;regulation of growth;negative regulation of Wnt signaling pathway;organic substance metabolic process;negative regulation of canonical Wnt signaling pathway;protein phosphorylation;positive regulation of phosphate metabolic process;cellular protein modification process;regulation of phosphorus metabolic process;single-organism cellular process;cell communication;growth;primary metabolic process;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;DNA metabolic process;regulation of protein phosphorylation;positive regulation of protein phosphorylation;negative regulation of cellular process;positive regulation of cellular process; 6;4;3;3;3;3;5;5;4;5;6;7;2;3;4;4;4;4;5;2;2;4;4;4;7;3;7;3;4;6;5;6;4;3;6;8;5;4;2;5;3;4;5;3;2;4;6;3;3;6;7;5;5;1;2;4;5;5;7;3;2;6;3;5;5;6;4;3;3;4;4;2;4;3;4;4;2;6;4;5;5;5;5;5;6;2;2;3;2;4;4;5;4;5;5;4;3;4;4;4;4;5;4;3;5;3;6;7;6;6;5;3;4;2;3;3;3;5;4;5;7;7;3;3; GO:0044421;GO:0005615;GO:0005575;GO:0005576; extracellular region part;extracellular space;cellular_component;extracellular region; 2;3;1;2; GO:0003674;GO:0005488;GO:0019838;GO:0005520;GO:0005515;GO:0005102;GO:0031994;GO:0031995; molecular_function;binding;growth factor binding;insulin-like growth factor binding;protein binding;receptor binding;insulin-like growth factor I binding;insulin-like growth factor II binding; 1;2;4;5;3;4;6;6; K23576 IPR022327;IPR009168;IPR022321;IPR000716;IPR017891;IPR009030;IPR000867; Insulin-like growth factor-binding protein 4;Insulin-like growth factor binding protein;Insulin-like growth factor-binding protein family 1-6, chordata;Thyroglobulin type-1;Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site;Growth factor receptor cysteine-rich domain;Insulin-like growth factor-binding protein, IGFBP; extracellular Q9NR99 Matrix-remodeling-associated protein 5 OS=Homo sapiens OX=9606 GN=MXRA5 PE=1 SV=3 - [MXRA5_HUMAN] 0.88 0.97 1.092 1.062 1.045 1.502 0.907216495 nan 1.016267943 nan 1.125773196 nan 1.437320574 nan GO:0043230;GO:0070062;GO:0044421;GO:0005575;GO:0005576;GO:1903561;GO:0043227;GO:0043226;GO:0031982; extracellular organelle;extracellular exosome;extracellular region part;cellular_component;extracellular region;extracellular vesicle;membrane-bounded organelle;organelle;vesicle; 3;4;2;1;2;3;3;2;4; IPR003599;IPR007110;IPR013783;IPR013098;IPR032675;IPR003591;IPR001611;IPR003598;IPR000483;IPR000372; Immunoglobulin subtype;Immunoglobulin-like domain;Immunoglobulin-like fold;Immunoglobulin I-set;Leucine-rich repeat domain, L domain-like;Leucine-rich repeat, typical subtype;Leucine-rich repeat;Immunoglobulin subtype 2;Cysteine-rich flanking region, C-terminal;Leucine-rich repeat N-terminal domain; extracellular Hs18390319 5841.0 R [R] General function prediction only; Q9BX97 Plasmalemma vesicle-associated protein OS=Homo sapiens OX=9606 GN=PLVAP PE=2 SV=1 - [PLVAP_HUMAN] 1.124 1.095 0.939 0.927 0.981 1.413 1.026484018 nan 0.944954128 nan 0.857534247 nan 1.440366972 nan GO:0019221;GO:0007165;GO:0007166;GO:0023014;GO:0051716;GO:0000165;GO:0048518;GO:0002682;GO:0010033;GO:0044700;GO:0048870;GO:0019538;GO:0002376;GO:0006468;GO:0006928;GO:0051674;GO:0035556;GO:0050789;GO:0044267;GO:0044260;GO:0071356;GO:0002687;GO:0002684;GO:0002685;GO:0065007;GO:0016477;GO:0034097;GO:0044710;GO:0050794;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0071345;GO:0050896;GO:0002691;GO:2000147;GO:0016310;GO:0033209;GO:0023052;GO:0070887;GO:0042221;GO:0044699;GO:0044238;GO:0009987;GO:0040012;GO:0032879;GO:0043170;GO:0050900;GO:0071704;GO:0071310;GO:2000145;GO:0030335;GO:0030334;GO:0002693;GO:0034612;GO:0006464;GO:0044763;GO:0007154;GO:0051179;GO:0040011;GO:0051272;GO:0051270;GO:0040017;GO:0045123;GO:0044237;GO:0006796;GO:0006793;GO:0048522; cytokine-mediated signaling pathway;signal transduction;cell surface receptor signaling pathway;signal transduction by protein phosphorylation;cellular response to stimulus;MAPK cascade;positive regulation of biological process;regulation of immune system process;response to organic substance;single organism signaling;cell motility;protein metabolic process;immune system process;protein phosphorylation;movement of cell or subcellular component;localization of cell;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;cellular response to tumor necrosis factor;positive regulation of leukocyte migration;positive regulation of immune system process;regulation of leukocyte migration;biological regulation;cell migration;response to cytokine;single-organism metabolic process;regulation of cellular process;macromolecule modification;protein modification process;biological_process;metabolic process;cellular response to cytokine stimulus;response to stimulus;regulation of cellular extravasation;positive regulation of cell motility;phosphorylation;tumor necrosis factor-mediated signaling pathway;signaling;cellular response to chemical stimulus;response to chemical;single-organism process;primary metabolic process;cellular process;regulation of locomotion;regulation of localization;macromolecule metabolic process;leukocyte migration;organic substance metabolic process;cellular response to organic substance;regulation of cell motility;positive regulation of cell migration;regulation of cell migration;positive regulation of cellular extravasation;response to tumor necrosis factor;cellular protein modification process;single-organism cellular process;cell communication;localization;locomotion;positive regulation of cellular component movement;regulation of cellular component movement;positive regulation of locomotion;cellular extravasation;cellular metabolic process;phosphate-containing compound metabolic process;phosphorus metabolic process;positive regulation of cellular process; 6;4;5;4;3;5;2;3;4;3;3;4;2;7;4;3;5;2;5;4;7;4;3;4;2;4;5;3;3;5;5;1;2;6;2;5;4;6;7;2;4;3;2;3;2;3;3;4;3;3;5;4;5;5;5;6;6;3;4;2;2;4;4;3;4;3;5;4;3; GO:0044853;GO:0031982;GO:0016021;GO:0016020;GO:0098589;GO:0043230;GO:0044424;GO:0044425;GO:0098857;GO:0044421;GO:0098590;GO:0005622;GO:0043227;GO:0031224;GO:0048471;GO:0044444;GO:0005901;GO:0005737;GO:0044459;GO:0009986;GO:0044464;GO:0005623;GO:0071944;GO:0070062;GO:0098805;GO:0043226;GO:0005886;GO:1903561;GO:0045121;GO:0005575;GO:0005576; plasma membrane raft;vesicle;integral component of membrane;membrane;membrane region;extracellular organelle;intracellular part;membrane part;membrane microdomain;extracellular region part;plasma membrane region;intracellular;membrane-bounded organelle;intrinsic component of membrane;perinuclear region of cytoplasm;cytoplasmic part;caveola;cytoplasm;plasma membrane part;cell surface;cell part;cell;cell periphery;extracellular exosome;whole membrane;organelle;plasma membrane;extracellular vesicle;membrane raft;cellular_component;extracellular region; 4;4;4;2;3;3;3;2;4;2;4;3;3;3;5;4;5;4;3;3;2;2;3;4;3;2;3;3;5;1;2; K17309 IPR009538; PV-1; plasma membrane P05452 Tetranectin OS=Homo sapiens OX=9606 GN=CLEC3B PE=1 SV=3 - [TETN_HUMAN] 0.988 1.192 0.872 1.032 1.152 0.881 0.82885906 2.44E-08 0.895833333 0.022149005 0.731543624 6.10E-10 0.764756944 0.315610628 GO:0080090;GO:0019222;GO:0001503;GO:0044707;GO:0051716;GO:0010604;GO:0070848;GO:0048513;GO:0048518;GO:0060255;GO:0030162;GO:0010033;GO:0010467;GO:0019538;GO:0010468;GO:0009893;GO:0043170;GO:0030282;GO:0044267;GO:0044260;GO:0065007;GO:0009719;GO:0009888;GO:0050794;GO:0008150;GO:0008152;GO:0045862;GO:0070613;GO:0051604;GO:0050896;GO:1903319;GO:1903317;GO:0070887;GO:0044699;GO:0051246;GO:0051247;GO:0032270;GO:0006508;GO:0071495;GO:0032501;GO:0009987;GO:0016485;GO:0032268;GO:0071363;GO:0071560;GO:0010628;GO:0048731;GO:0032502;GO:0031325;GO:0031323;GO:0007275;GO:0031639;GO:0031638;GO:0050789;GO:0071704;GO:0071310;GO:0071559;GO:0044767;GO:0031214;GO:0042221;GO:0010954;GO:0044238;GO:0048856;GO:0044237;GO:0010756;GO:0010755;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;ossification;single-multicellular organism process;cellular response to stimulus;positive regulation of macromolecule metabolic process;response to growth factor;animal organ development;positive regulation of biological process;regulation of macromolecule metabolic process;regulation of proteolysis;response to organic substance;gene expression;protein metabolic process;regulation of gene expression;positive regulation of metabolic process;macromolecule metabolic process;bone mineralization;cellular protein metabolic process;cellular macromolecule metabolic process;biological regulation;response to endogenous stimulus;tissue development;regulation of cellular process;biological_process;metabolic process;positive regulation of proteolysis;regulation of protein processing;protein maturation;response to stimulus;positive regulation of protein maturation;regulation of protein maturation;cellular response to chemical stimulus;single-organism process;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of cellular protein metabolic process;proteolysis;cellular response to endogenous stimulus;multicellular organismal process;cellular process;protein processing;regulation of cellular protein metabolic process;cellular response to growth factor stimulus;cellular response to transforming growth factor beta stimulus;positive regulation of gene expression;system development;developmental process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;multicellular organism development;plasminogen activation;zymogen activation;regulation of biological process;organic substance metabolic process;cellular response to organic substance;response to transforming growth factor beta;single-organism developmental process;biomineral tissue development;response to chemical;positive regulation of protein processing;primary metabolic process;anatomical structure development;cellular metabolic process;positive regulation of plasminogen activation;regulation of plasminogen activation;positive regulation of cellular process; 4;3;4;3;3;4;5;4;2;4;6;4;5;4;5;3;4;5;5;4;2;3;4;3;1;2;6;7;5;2;6;6;4;2;5;5;5;5;4;2;2;6;5;6;5;5;4;2;4;4;4;8;7;2;3;5;4;3;5;3;7;3;3;3;8;8;3; GO:0031974;GO:0031981;GO:0005615;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0044428;GO:0044424;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0031982;GO:0044446;GO:0043226;GO:0005737;GO:0005730;GO:0005634;GO:0044452;GO:0001652;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:1903561;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;nuclear lumen;extracellular space;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;nuclear part;intracellular part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;vesicle;intracellular organelle part;organelle;cytoplasm;nucleolus;nucleus;nucleolar part;granular component;cell part;cell;intracellular;extracellular exosome;extracellular vesicle;cellular_component;intracellular organelle lumen;extracellular region; 2;5;3;3;4;4;3;4;3;2;2;3;3;3;4;3;2;4;5;5;5;6;2;2;3;4;3;1;4;2; GO:0046872;GO:0019904;GO:0097367;GO:0003674;GO:0005488;GO:0043169;GO:0043167;GO:0005509;GO:0008201;GO:0005515;GO:0030246;GO:1901681;GO:0005539;GO:0036143;GO:0043168; metal ion binding;protein domain specific binding;carbohydrate derivative binding;molecular_function;binding;cation binding;ion binding;calcium ion binding;heparin binding;protein binding;carbohydrate binding;sulfur compound binding;glycosaminoglycan binding;kringle domain binding;anion binding; 5;4;3;1;2;4;3;6;4;3;3;3;4;5;4; K17520 IPR016186;IPR018378;IPR001304;IPR016187; C-type lectin-like/link domain;C-type lectin, conserved site;C-type lectin-like;C-type lectin fold; extracellular Hs4507557 418.0 TV [T] Signal transduction mechanisms;[V] Defense mechanisms; P55265 Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4 - [DSRAD_HUMAN] 0.984 1.026 0.981 1.04 1.082 1.32 0.959064327 nan 0.961182994 nan 0.956140351 nan 1.219963031 nan GO:0051169;GO:0008104;GO:0019220;GO:0019221;GO:0019222;GO:0030218;GO:0048585;GO:0048583;GO:0009451;GO:0031050;GO:0051168;GO:0007165;GO:0007166;GO:0044744;GO:1901576;GO:0016556;GO:1901360;GO:0080090;GO:0006950;GO:0051716;GO:0010605;GO:0010604;GO:0070727;GO:0009966;GO:0010608;GO:0071840;GO:0043043;GO:0040029;GO:0044419;GO:0002252;GO:0016458;GO:0019058;GO:0044092;GO:0048518;GO:0048519;GO:0033036;GO:0006382;GO:0002262;GO:0002683;GO:0006397;GO:0034470;GO:0060337;GO:0010467;GO:0060255;GO:0048513;GO:0045859;GO:0006606;GO:0050777;GO:0006605;GO:0045184;GO:0060147;GO:0032268;GO:0045070;GO:0009607;GO:0060149;GO:0010033;GO:0051704;GO:0042325;GO:0044700;GO:0042326;GO:1901564;GO:0044707;GO:1901566;GO:0009790;GO:0019538;GO:0046483;GO:0002376;GO:0001503;GO:0043331;GO:0016553;GO:0016441;GO:0030099;GO:0031054;GO:0033673;GO:0022607;GO:0009892;GO:0034645;GO:0009890;GO:0006611;GO:0023051;GO:0002244;GO:0080134;GO:0010629;GO:0006807;GO:0034660;GO:0050789;GO:0070918;GO:0009605;GO:0044267;GO:1900369;GO:1900368;GO:0044260;GO:0071359;GO:0071357;GO:0006886;GO:0043549;GO:0016043;GO:0065003;GO:0045824;GO:0065007;GO:0014070;GO:0001960;GO:0009615;GO:0065009;GO:0065008;GO:0043067;GO:0050790;GO:0034097;GO:0050792;GO:0006810;GO:0009889;GO:0044710;GO:0050794;GO:0043902;GO:0043903;GO:0043900;GO:0036211;GO:0008150;GO:0051348;GO:0008152;GO:0048731;GO:0060761;GO:0031347;GO:0051234;GO:0002520;GO:0016070;GO:0044767;GO:0044271;GO:0006417;GO:0046907;GO:0060966;GO:0071345;GO:0050896;GO:1901699;GO:0043412;GO:0051338;GO:0043901;GO:0050776;GO:0048869;GO:0006915;GO:0051170;GO:0006518;GO:0043207;GO:0010558;GO:0051171;GO:0060967;GO:0016310;GO:0017038;GO:0030154;GO:0001959;GO:0044249;GO:0034641;GO:0009792;GO:0023052;GO:0060759;GO:0070887;GO:0007154;GO:0034340;GO:0010646;GO:0043086;GO:0044699;GO:0009893;GO:0006139;GO:0051248;GO:0001701;GO:1903900;GO:1903901;GO:1903902;GO:1901698;GO:0010563;GO:0051246;GO:0045071;GO:0043933;GO:0042592;GO:0022618;GO:0060969;GO:0031399;GO:0022613;GO:0043009;GO:0060968;GO:0006952;GO:0032502;GO:0032501;GO:0016071;GO:0019079;GO:0072594;GO:0009987;GO:0006725;GO:0034249;GO:0034248;GO:0009058;GO:0006955;GO:0060216;GO:0043066;GO:0098542;GO:0051607;GO:0051707;GO:0043604;GO:0032269;GO:1902582;GO:0043603;GO:0098586;GO:0071407;GO:0045069;GO:0061484;GO:0009059;GO:0043170;GO:0060548;GO:0010628;GO:0017148;GO:0033365;GO:0030097;GO:0031400;GO:0034504;GO:0048524;GO:0031327;GO:0031326;GO:0044387;GO:0031324;GO:0031323;GO:0090304;GO:0034622;GO:0035280;GO:0008219;GO:0010941;GO:0035455;GO:0007275;GO:0001649;GO:0002200;GO:0071826;GO:0002682;GO:0042981;GO:0012501;GO:1902593;GO:2000112;GO:2000113;GO:0071704;GO:0071310;GO:0010556;GO:0071702;GO:0016246;GO:0048534;GO:0043069;GO:0010468;GO:0048872;GO:0031348;GO:0034101;GO:0006468;GO:0006469;GO:0045088;GO:0045936;GO:0060339;GO:0045087;GO:0034613;GO:0006913;GO:0006464;GO:0051174;GO:0048525;GO:0044765;GO:0044764;GO:0044763;GO:0031047;GO:0051172;GO:0051649;GO:0042221;GO:0060338;GO:0009968;GO:0070922;GO:0051179;GO:1902578;GO:0051641;GO:0044238;GO:1902580;GO:0002566;GO:0035194;GO:0035195;GO:0035196;GO:0048856;GO:0044237;GO:0006796;GO:0044085;GO:0010648;GO:0006396;GO:0016032;GO:0006793;GO:0015031;GO:0044403;GO:0001933;GO:0001932;GO:0023057;GO:0006412;GO:0048523;GO:0048522; nuclear transport;protein localization;regulation of phosphate metabolic process;cytokine-mediated signaling pathway;regulation of metabolic process;erythrocyte differentiation;negative regulation of response to stimulus;regulation of response to stimulus;RNA modification;dsRNA fragmentation;nuclear export;signal transduction;cell surface receptor signaling pathway;protein targeting to nucleus;organic substance biosynthetic process;mRNA modification;organic cyclic compound metabolic process;regulation of primary metabolic process;response to stress;cellular response to stimulus;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;cellular macromolecule localization;regulation of signal transduction;posttranscriptional regulation of gene expression;cellular component organization or biogenesis;peptide biosynthetic process;regulation of gene expression, epigenetic;interspecies interaction between organisms;immune effector process;gene silencing;viral life cycle;negative regulation of molecular function;positive regulation of biological process;negative regulation of biological process;macromolecule localization;adenosine to inosine editing;myeloid cell homeostasis;negative regulation of immune system process;mRNA processing;ncRNA processing;type I interferon signaling pathway;gene expression;regulation of macromolecule metabolic process;animal organ development;regulation of protein kinase activity;protein import into nucleus;negative regulation of immune response;protein targeting;establishment of protein localization;regulation of posttranscriptional gene silencing;regulation of cellular protein metabolic process;positive regulation of viral genome replication;response to biotic stimulus;negative regulation of posttranscriptional gene silencing;response to organic substance;multi-organism process;regulation of phosphorylation;single organism signaling;negative regulation of phosphorylation;organonitrogen compound metabolic process;single-multicellular organism process;organonitrogen compound biosynthetic process;embryo development;protein metabolic process;heterocycle metabolic process;immune system process;ossification;response to dsRNA;base conversion or substitution editing;posttranscriptional gene silencing;myeloid cell differentiation;pre-miRNA processing;negative regulation of kinase activity;cellular component assembly;negative regulation of metabolic process;cellular macromolecule biosynthetic process;negative regulation of biosynthetic process;protein export from nucleus;regulation of signaling;hematopoietic progenitor cell differentiation;regulation of response to stress;negative regulation of gene expression;nitrogen compound metabolic process;ncRNA metabolic process;regulation of biological process;production of small RNA involved in gene silencing by RNA;response to external stimulus;cellular protein metabolic process;negative regulation of RNA interference;regulation of RNA interference;cellular macromolecule metabolic process;cellular response to dsRNA;cellular response to type I interferon;intracellular protein transport;regulation of kinase activity;cellular component organization;macromolecular complex assembly;negative regulation of innate immune response;biological regulation;response to organic cyclic compound;negative regulation of cytokine-mediated signaling pathway;response to virus;regulation of molecular function;regulation of biological quality;regulation of programmed cell death;regulation of catalytic activity;response to cytokine;regulation of viral process;transport;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;positive regulation of multi-organism process;regulation of symbiosis, encompassing mutualism through parasitism;regulation of multi-organism process;protein modification process;biological_process;negative regulation of transferase activity;metabolic process;system development;negative regulation of response to cytokine stimulus;regulation of defense response;establishment of localization;immune system development;RNA metabolic process;single-organism developmental process;cellular nitrogen compound biosynthetic process;regulation of translation;intracellular transport;regulation of gene silencing by RNA;cellular response to cytokine stimulus;response to stimulus;cellular response to nitrogen compound;macromolecule modification;regulation of transferase activity;negative regulation of multi-organism process;regulation of immune response;cellular developmental process;apoptotic process;nuclear import;peptide metabolic process;response to external biotic stimulus;negative regulation of macromolecule biosynthetic process;regulation of nitrogen compound metabolic process;negative regulation of gene silencing by RNA;phosphorylation;protein import;cell differentiation;regulation of cytokine-mediated signaling pathway;cellular biosynthetic process;cellular nitrogen compound metabolic process;embryo development ending in birth or egg hatching;signaling;regulation of response to cytokine stimulus;cellular response to chemical stimulus;cell communication;response to type I interferon;regulation of cell communication;negative regulation of catalytic activity;single-organism process;positive regulation of metabolic process;nucleobase-containing compound metabolic process;negative regulation of protein metabolic process;in utero embryonic development;regulation of viral life cycle;negative regulation of viral life cycle;positive regulation of viral life cycle;response to nitrogen compound;negative regulation of phosphorus metabolic process;regulation of protein metabolic process;negative regulation of viral genome replication;macromolecular complex subunit organization;homeostatic process;ribonucleoprotein complex assembly;negative regulation of gene silencing;regulation of protein modification process;ribonucleoprotein complex biogenesis;chordate embryonic development;regulation of gene silencing;defense response;developmental process;multicellular organismal process;mRNA metabolic process;viral genome replication;establishment of protein localization to organelle;cellular process;cellular aromatic compound metabolic process;negative regulation of cellular amide metabolic process;regulation of cellular amide metabolic process;biosynthetic process;immune response;definitive hemopoiesis;negative regulation of apoptotic process;defense response to other organism;defense response to virus;response to other organism;amide biosynthetic process;negative regulation of cellular protein metabolic process;single-organism intracellular transport;cellular amide metabolic process;cellular response to virus;cellular response to organic cyclic compound;regulation of viral genome replication;hematopoietic stem cell homeostasis;macromolecule biosynthetic process;macromolecule metabolic process;negative regulation of cell death;positive regulation of gene expression;negative regulation of translation;protein localization to organelle;hemopoiesis;negative regulation of protein modification process;protein localization to nucleus;positive regulation of viral process;negative regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;negative regulation of protein kinase activity by regulation of protein phosphorylation;negative regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular macromolecular complex assembly;miRNA loading onto RISC involved in gene silencing by miRNA;cell death;regulation of cell death;response to interferon-alpha;multicellular organism development;osteoblast differentiation;somatic diversification of immune receptors;ribonucleoprotein complex subunit organization;regulation of immune system process;regulation of apoptotic process;programmed cell death;single-organism nuclear import;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;organic substance metabolic process;cellular response to organic substance;regulation of macromolecule biosynthetic process;organic substance transport;RNA interference;hematopoietic or lymphoid organ development;negative regulation of programmed cell death;regulation of gene expression;homeostasis of number of cells;negative regulation of defense response;erythrocyte homeostasis;protein phosphorylation;negative regulation of protein kinase activity;regulation of innate immune response;negative regulation of phosphate metabolic process;negative regulation of type I interferon-mediated signaling pathway;innate immune response;cellular protein localization;nucleocytoplasmic transport;cellular protein modification process;regulation of phosphorus metabolic process;negative regulation of viral process;single-organism transport;multi-organism cellular process;single-organism cellular process;gene silencing by RNA;negative regulation of nitrogen compound metabolic process;establishment of localization in cell;response to chemical;regulation of type I interferon-mediated signaling pathway;negative regulation of signal transduction;small RNA loading onto RISC;localization;single-organism localization;cellular localization;primary metabolic process;single-organism cellular localization;somatic diversification of immune receptors via somatic mutation;posttranscriptional gene silencing by RNA;gene silencing by miRNA;production of miRNAs involved in gene silencing by miRNA;anatomical structure development;cellular metabolic process;phosphate-containing compound metabolic process;cellular component biogenesis;negative regulation of cell communication;RNA processing;viral process;phosphorus metabolic process;protein transport;symbiosis, encompassing mutualism through parasitism;negative regulation of protein phosphorylation;regulation of protein phosphorylation;negative regulation of signaling;translation;negative regulation of cellular process;positive regulation of cellular process; 6;4;6;6;3;5;3;3;6;4;8;4;5;5;4;7;4;4;3;3;4;4;4;4;6;2;6;6;3;3;4;5;4;2;2;3;8;3;3;7;7;7;5;4;4;7;5;4;6;4;5;5;6;3;5;4;2;7;3;7;4;3;5;5;4;4;2;4;5;7;5;6;7;7;4;3;5;4;6;3;6;4;5;3;6;2;5;3;5;6;6;4;6;6;6;6;3;5;5;2;5;5;4;3;3;5;4;5;4;4;4;3;3;3;4;3;5;1;6;2;4;4;5;3;3;5;3;5;6;5;5;6;2;5;5;5;3;4;4;6;8;5;4;5;4;5;6;5;5;5;4;4;6;2;4;4;4;5;4;5;2;3;4;5;8;5;5;5;4;5;5;6;4;4;5;4;6;4;7;4;4;2;2;6;5;5;2;4;5;5;3;3;6;6;4;4;3;6;5;5;5;5;6;6;6;5;4;4;5;6;6;5;6;7;4;5;5;9;4;4;5;6;7;4;4;6;4;5;3;5;3;6;5;6;6;6;3;5;5;5;7;4;5;5;5;4;4;7;8;5;6;6;4;5;7;6;5;4;4;3;3;5;4;4;3;6;4;6;2;3;3;3;4;4;6;7;6;3;3;5;3;4;6;4;4;5;4;7;7;3;6;3;3; GO:0031974;GO:0030529;GO:0005654;GO:0031981;GO:0016020;GO:0043233;GO:0044422;GO:1990904;GO:0043232;GO:0005622;GO:0043227;GO:0044428;GO:0044446;GO:0043231;GO:0005737;GO:0005730;GO:0005634;GO:0005681;GO:0032991;GO:0044464;GO:0043229;GO:0044424;GO:0005623;GO:0043226;GO:0043228;GO:0044530;GO:0005575;GO:0070013; membrane-enclosed lumen;intracellular ribonucleoprotein complex;nucleoplasm;nuclear lumen;membrane;organelle lumen;organelle part;ribonucleoprotein complex;intracellular non-membrane-bounded organelle;intracellular;membrane-bounded organelle;nuclear part;intracellular organelle part;intracellular membrane-bounded organelle;cytoplasm;nucleolus;nucleus;spliceosomal complex;macromolecular complex;cell part;intracellular organelle;intracellular part;cell;organelle;non-membrane-bounded organelle;supraspliceosomal complex;cellular_component;intracellular organelle lumen; 2;4;5;5;2;3;2;3;4;3;3;4;3;4;4;5;5;5;2;2;3;3;2;2;3;6;1;4; GO:1901363;GO:0016810;GO:0016814;GO:0003824;GO:0003674;GO:0005488;GO:0003676;GO:0003677;GO:0019239;GO:0004000;GO:0016787;GO:0043169;GO:0097159;GO:0043167;GO:0044822;GO:0046872;GO:0003726;GO:0003723; heterocyclic compound binding;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;catalytic activity;molecular_function;binding;nucleic acid binding;DNA binding;deaminase activity;adenosine deaminase activity;hydrolase activity;cation binding;organic cyclic compound binding;ion binding;poly(A) RNA binding;metal ion binding;double-stranded RNA adenosine deaminase activity;RNA binding; 3;4;5;2;1;2;4;5;3;4;3;4;3;3;6;5;5;5; K12968 map04623;map05162;map05164; Cytosolic DNA-sensing pathway;Measles;Influenza A; IPR014720;IPR000607;IPR002466;IPR011991; Double-stranded RNA-binding domain;Double-stranded RNA-specific adenosine deaminase (DRADA);Adenosine deaminase/editase;Winged helix-turn-helix DNA-binding domain; nucleus Hs4501917 2549.0 A [A] RNA processing and modification; Q96JB2 Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3 - [COG3_HUMAN] 0.571 1.1 2.225 0.587 0.543 0.547 0.519090909 nan 1.081031308 nan 2.022727273 nan 1.007366483 nan GO:0008104;GO:0061024;GO:0071840;GO:0044710;GO:0070727;GO:0018196;GO:0010256;GO:0018193;GO:0033036;GO:0045184;GO:0016192;GO:0019538;GO:0050821;GO:1901576;GO:0006888;GO:0044260;GO:0006886;GO:0048193;GO:0016043;GO:0065007;GO:0065008;GO:0006810;GO:0043412;GO:0036211;GO:0008150;GO:0008152;GO:0044723;GO:0051234;GO:0006891;GO:0046907;GO:0031647;GO:0044765;GO:0043413;GO:0044249;GO:0034645;GO:0044699;GO:0043687;GO:0009987;GO:0006890;GO:0005975;GO:0007030;GO:1901137;GO:1901135;GO:0043170;GO:0033365;GO:0009100;GO:0009101;GO:0006486;GO:0006487;GO:0071704;GO:0071702;GO:0018279;GO:0044267;GO:0034613;GO:0070085;GO:0006464;GO:0009058;GO:0009059;GO:0044763;GO:0051649;GO:0051179;GO:1902578;GO:0051641;GO:0006996;GO:0044238;GO:0044237;GO:0015031;GO:1902582; protein localization;membrane organization;cellular component organization or biogenesis;single-organism metabolic process;cellular macromolecule localization;peptidyl-asparagine modification;endomembrane system organization;peptidyl-amino acid modification;macromolecule localization;establishment of protein localization;vesicle-mediated transport;protein metabolic process;protein stabilization;organic substance biosynthetic process;ER to Golgi vesicle-mediated transport;cellular macromolecule metabolic process;intracellular protein transport;Golgi vesicle transport;cellular component organization;biological regulation;regulation of biological quality;transport;macromolecule modification;protein modification process;biological_process;metabolic process;single-organism carbohydrate metabolic process;establishment of localization;intra-Golgi vesicle-mediated transport;intracellular transport;regulation of protein stability;single-organism transport;macromolecule glycosylation;cellular biosynthetic process;cellular macromolecule biosynthetic process;single-organism process;post-translational protein modification;cellular process;retrograde vesicle-mediated transport, Golgi to ER;carbohydrate metabolic process;Golgi organization;carbohydrate derivative biosynthetic process;carbohydrate derivative metabolic process;macromolecule metabolic process;protein localization to organelle;glycoprotein metabolic process;glycoprotein biosynthetic process;protein glycosylation;protein N-linked glycosylation;organic substance metabolic process;organic substance transport;protein N-linked glycosylation via asparagine;cellular protein metabolic process;cellular protein localization;glycosylation;cellular protein modification process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;establishment of localization in cell;localization;single-organism localization;cellular localization;organelle organization;primary metabolic process;cellular metabolic process;protein transport;single-organism intracellular transport; 4;4;2;3;4;8;4;7;3;4;5;4;5;4;7;4;6;6;3;2;3;4;5;5;1;2;4;3;7;5;4;4;6;4;5;2;7;2;7;4;5;5;4;4;6;5;6;4;5;3;5;6;5;5;5;6;3;5;3;4;2;3;3;4;3;3;5;5; GO:0031974;GO:0031984;GO:0031981;GO:0005795;GO:0005794;GO:0098588;GO:0043231;GO:0043234;GO:0043233;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0043226;GO:0005654;GO:0044431;GO:0031985;GO:0012505;GO:0000139;GO:0044446;GO:0044444;GO:0016020;GO:0005886;GO:0005737;GO:0031090;GO:0005634;GO:0032580;GO:0044464;GO:0005623;GO:0071944;GO:0017119;GO:0032991;GO:0005801;GO:0005575;GO:0070013;GO:0098791; membrane-enclosed lumen;organelle subcompartment;nuclear lumen;Golgi stack;Golgi apparatus;bounding membrane of organelle;intracellular membrane-bounded organelle;protein complex;organelle lumen;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;organelle;nucleoplasm;Golgi apparatus part;Golgi cisterna;endomembrane system;Golgi membrane;intracellular organelle part;cytoplasmic part;membrane;plasma membrane;cytoplasm;organelle membrane;nucleus;Golgi cisterna membrane;cell part;cell;cell periphery;Golgi transport complex;macromolecular complex;cis-Golgi network;cellular_component;intracellular organelle lumen;Golgi subcompartment; 2;4;5;5;4;4;4;3;3;4;3;2;3;3;3;2;5;4;6;3;5;3;4;2;3;4;3;5;6;2;2;3;4;2;5;1;4;5; GO:0003674;GO:0008565;GO:0022892;GO:0005215; molecular_function;protein transporter activity;substrate-specific transporter activity;transporter activity; 1;4;3;2; K20290 IPR007265; Conserved oligomeric Golgi complex, subunit 3; cytosol Hs13899251 1701.0 U [U] Intracellular trafficking, secretion, and vesicular transport; O60656 UDP-glucuronosyltransferase 1-9 OS=Homo sapiens OX=9606 GN=UGT1A9 PE=1 SV=1 - [UD19_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:0010677;GO:0044281;GO:2001030;GO:0042445;GO:0044710;GO:0042440;GO:0045833;GO:0044092;GO:0016101;GO:0032787;GO:2001029;GO:0043436;GO:1904223;GO:1904224;GO:0009892;GO:0006805;GO:0050789;GO:0044262;GO:0051348;GO:0065007;GO:0045912;GO:0065009;GO:0065008;GO:0006629;GO:0050790;GO:0051716;GO:0050794;GO:0008150;GO:0008152;GO:0044723;GO:0050896;GO:0009812;GO:0051338;GO:0006109;GO:0006631;GO:0052695;GO:0052696;GO:0052697;GO:0009410;GO:0070887;GO:0042573;GO:0043086;GO:0044699;GO:0010565;GO:0006721;GO:0006720;GO:0009987;GO:0010675;GO:0048519;GO:0044255;GO:0051552;GO:0006082;GO:0005996;GO:0045922;GO:0031324;GO:0031323;GO:0019752;GO:0001523;GO:0071466;GO:0071704;GO:0019585;GO:0019217;GO:0019216;GO:0010817;GO:0044763;GO:0042221;GO:0034754;GO:0044238;GO:0005975;GO:0042180;GO:0044237;GO:0006063;GO:0048523; regulation of primary metabolic process;regulation of metabolic process;negative regulation of cellular carbohydrate metabolic process;small molecule metabolic process;negative regulation of cellular glucuronidation;hormone metabolic process;single-organism metabolic process;pigment metabolic process;negative regulation of lipid metabolic process;negative regulation of molecular function;diterpenoid metabolic process;monocarboxylic acid metabolic process;regulation of cellular glucuronidation;oxoacid metabolic process;regulation of glucuronosyltransferase activity;negative regulation of glucuronosyltransferase activity;negative regulation of metabolic process;xenobiotic metabolic process;regulation of biological process;cellular carbohydrate metabolic process;negative regulation of transferase activity;biological regulation;negative regulation of carbohydrate metabolic process;regulation of molecular function;regulation of biological quality;lipid metabolic process;regulation of catalytic activity;cellular response to stimulus;regulation of cellular process;biological_process;metabolic process;single-organism carbohydrate metabolic process;response to stimulus;flavonoid metabolic process;regulation of transferase activity;regulation of carbohydrate metabolic process;fatty acid metabolic process;cellular glucuronidation;flavonoid glucuronidation;xenobiotic glucuronidation;response to xenobiotic stimulus;cellular response to chemical stimulus;retinoic acid metabolic process;negative regulation of catalytic activity;single-organism process;regulation of cellular ketone metabolic process;terpenoid metabolic process;isoprenoid metabolic process;cellular process;regulation of cellular carbohydrate metabolic process;negative regulation of biological process;cellular lipid metabolic process;flavone metabolic process;organic acid metabolic process;monosaccharide metabolic process;negative regulation of fatty acid metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;carboxylic acid metabolic process;retinoid metabolic process;cellular response to xenobiotic stimulus;organic substance metabolic process;glucuronate metabolic process;regulation of fatty acid metabolic process;regulation of lipid metabolic process;regulation of hormone levels;single-organism cellular process;response to chemical;cellular hormone metabolic process;primary metabolic process;carbohydrate metabolic process;cellular ketone metabolic process;cellular metabolic process;uronic acid metabolic process;negative regulation of cellular process; 4;3;5;4;6;3;3;4;4;4;7;7;6;5;6;7;3;4;2;4;6;2;4;3;3;4;4;3;3;1;2;4;2;4;5;5;5;8;5;5;4;4;5;5;2;5;6;5;2;5;2;4;5;4;5;5;4;4;6;8;5;3;7;6;5;4;3;3;4;3;4;4;3;6;3; GO:0005789;GO:0005783;GO:0031982;GO:0016021;GO:0016020;GO:0098588;GO:0043230;GO:0043231;GO:0044424;GO:0044425;GO:0044421;GO:0044422;GO:0043229;GO:0043227;GO:0044432;GO:0031224;GO:0012505;GO:0044446;GO:0044444;GO:0042175;GO:0005737;GO:0031090;GO:0044464;GO:0005623;GO:0005622;GO:0070062;GO:0043226;GO:1903561;GO:0005575;GO:0005576; endoplasmic reticulum membrane;endoplasmic reticulum;vesicle;integral component of membrane;membrane;bounding membrane of organelle;extracellular organelle;intracellular membrane-bounded organelle;intracellular part;membrane part;extracellular region part;organelle part;intracellular organelle;membrane-bounded organelle;endoplasmic reticulum part;intrinsic component of membrane;endomembrane system;intracellular organelle part;cytoplasmic part;nuclear outer membrane-endoplasmic reticulum membrane network;cytoplasm;organelle membrane;cell part;cell;intracellular;extracellular exosome;organelle;extracellular vesicle;cellular_component;extracellular region; 3;4;4;4;2;4;3;4;3;2;2;2;3;3;4;3;3;3;4;3;4;3;2;2;3;4;2;3;1;2; GO:0098772;GO:0033293;GO:0016740;GO:0016757;GO:0003674;GO:0005488;GO:0043168;GO:0003824;GO:0016758;GO:0001972;GO:0046983;GO:0046982;GO:0019899;GO:0004857;GO:0043167;GO:0005501;GO:0042802;GO:0042803;GO:0008289;GO:0043177;GO:0005515;GO:0031406;GO:0015020;GO:0030234;GO:0036094;GO:0008194;GO:0019840; molecular function regulator;monocarboxylic acid binding;transferase activity;transferase activity, transferring glycosyl groups;molecular_function;binding;anion binding;catalytic activity;transferase activity, transferring hexosyl groups;retinoic acid binding;protein dimerization activity;protein heterodimerization activity;enzyme binding;enzyme inhibitor activity;ion binding;retinoid binding;identical protein binding;protein homodimerization activity;lipid binding;organic acid binding;protein binding;carboxylic acid binding;glucuronosyltransferase activity;enzyme regulator activity;small molecule binding;UDP-glycosyltransferase activity;isoprenoid binding; 2;6;3;4;1;2;4;2;5;6;4;5;4;4;3;5;4;5;3;4;3;5;6;3;3;5;4; K00699 map00040;map00053;map00140;map00500;map00830;map00860;map00980;map00982;map00983;map01100;map05204; Pentose and glucuronate interconversions;Ascorbate and aldarate metabolism;Steroid hormone biosynthesis;Starch and sucrose metabolism;Retinol metabolism;Porphyrin and chlorophyll metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism - cytochrome P450;Drug metabolism - other enzymes;Metabolic pathways;Chemical carcinogenesis; IPR035595;IPR002213; UDP-glycosyltransferase family, conserved site;UDP-glucuronosyl/UDP-glucosyltransferase; extracellular Hs11276085 1108.0 GC [G] Carbohydrate transport and metabolism;[C] Energy production and conversion; P26717 NKG2-C type II integral membrane protein OS=Homo sapiens OX=9606 GN=KLRC2 PE=1 SV=2 - [NKG2C_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0006968;GO:0006955;GO:0007165;GO:0050789;GO:0044699;GO:0002376;GO:0051716;GO:0002228;GO:0065007;GO:0044700;GO:0045087;GO:0009987;GO:0050794;GO:0006952;GO:0002449;GO:0006950;GO:0008150;GO:0023052;GO:0007154;GO:0002443;GO:0050896;GO:0002252;GO:0044763; cellular defense response;immune response;signal transduction;regulation of biological process;single-organism process;immune system process;cellular response to stimulus;natural killer cell mediated immunity;biological regulation;single organism signaling;innate immune response;cellular process;regulation of cellular process;defense response;lymphocyte mediated immunity;response to stress;biological_process;signaling;cell communication;leukocyte mediated immunity;response to stimulus;immune effector process;single-organism cellular process; 5;3;4;2;2;2;3;5;2;3;4;2;3;4;5;3;1;2;4;4;2;3;3; GO:0005887;GO:0071944;GO:0031226;GO:0016021;GO:0016020;GO:0031224;GO:0044425;GO:0044459;GO:0005886;GO:0043234;GO:0043235;GO:0032991;GO:0044464;GO:0005623;GO:0005575; integral component of plasma membrane;cell periphery;intrinsic component of plasma membrane;integral component of membrane;membrane;intrinsic component of membrane;membrane part;plasma membrane part;plasma membrane;protein complex;receptor complex;macromolecular complex;cell part;cell;cellular_component; 4;3;4;4;2;3;2;3;3;3;4;2;2;2;1; GO:0003823;GO:0038023;GO:1990405;GO:0030246;GO:0060089;GO:0003674;GO:0005488;GO:0004871;GO:0023024;GO:0032403;GO:0044877;GO:0023023;GO:0004888;GO:0005515;GO:0099600;GO:0004872; antigen binding;signaling receptor activity;protein antigen binding;carbohydrate binding;molecular transducer activity;molecular_function;binding;signal transducer activity;MHC class I protein complex binding;protein complex binding;macromolecular complex binding;MHC protein complex binding;transmembrane signaling receptor activity;protein binding;transmembrane receptor activity;receptor activity; 3;3;4;3;2;1;2;2;5;4;3;4;4;3;4;3; K06541 map04612; Antigen processing and presentation; IPR033992;IPR016186;IPR001304;IPR016187; Natural killer cell receptor-like, C-type lectin-like domain;C-type lectin-like/link domain;C-type lectin-like;C-type lectin fold; cytosol Q6KC79 Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2 - [NIPBL_HUMAN] 1.138 0.775 1.066 1.135 1.195 0.568 1.468387097 nan 0.949790795 nan 1.375483871 nan 0.475313808 nan GO:0001503;GO:0048639;GO:0008104;GO:0080090;GO:0048589;GO:0031063;GO:0035107;GO:0006476;GO:0001501;GO:0072359;GO:0035261;GO:1904888;GO:0060324;GO:0035264;GO:0031056;GO:0031058;GO:1901362;GO:0010171;GO:0071840;GO:0003151;GO:0016575;GO:0051716;GO:0010605;GO:0000003;GO:0070727;GO:0048869;GO:0034086;GO:0001822;GO:0033043;GO:0051246;GO:0048513;GO:0034088;GO:0048518;GO:0048806;GO:0035239;GO:0003008;GO:0016570;GO:0060255;GO:0007600;GO:0003007;GO:0003006;GO:0032268;GO:0045995;GO:2001141;GO:0007605;GO:0046483;GO:0019827;GO:0044702;GO:0044707;GO:0044249;GO:0043933;GO:0010638;GO:0060323;GO:0019538;GO:0072358;GO:0033554;GO:0019438;GO:0016569;GO:0051130;GO:0051252;GO:0009892;GO:0009893;GO:0009890;GO:0061008;GO:0048568;GO:0060173;GO:0051254;GO:0008152;GO:0060065;GO:0007064;GO:0007067;GO:0043170;GO:0097659;GO:0007062;GO:0060322;GO:1901576;GO:0044260;GO:0016043;GO:0019219;GO:0065007;GO:0007049;GO:1903308;GO:0006366;GO:0071214;GO:0090311;GO:0055123;GO:0018130;GO:0048705;GO:0048704;GO:0009887;GO:0048706;GO:0048701;GO:0048703;GO:0006139;GO:0050793;GO:0050954;GO:0051240;GO:0009889;GO:0044710;GO:0050794;GO:0098727;GO:0006950;GO:0036211;GO:0008150;GO:0006464;GO:0051239;GO:0060325;GO:0034654;GO:0007059;GO:0030278;GO:0042303;GO:0016070;GO:1902679;GO:0007548;GO:0044271;GO:0007420;GO:0007423;GO:0035115;GO:0050896;GO:0031401;GO:0050890;GO:0043412;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0048557;GO:2001252;GO:0010558;GO:0033044;GO:0048638;GO:0032774;GO:0071481;GO:0009314;GO:0030154;GO:0051128;GO:0035108;GO:0009790;GO:0034641;GO:0048562;GO:1901360;GO:0034645;GO:0098732;GO:0048565;GO:0009653;GO:0035295;GO:0044699;GO:0007417;GO:0010165;GO:0071479;GO:0071478;GO:0010212;GO:0000122;GO:0009891;GO:0000280;GO:0051247;GO:0031327;GO:0016568;GO:0032270;GO:0031399;GO:0043009;GO:0051641;GO:0032502;GO:0042471;GO:0032501;GO:0048608;GO:0035601;GO:0044238;GO:0050877;GO:0009987;GO:0006725;GO:1903506;GO:1903507;GO:0006974;GO:0045892;GO:0001655;GO:0001656;GO:0048519;GO:0042634;GO:0072001;GO:0040014;GO:0033036;GO:0000819;GO:0051094;GO:0045893;GO:0051253;GO:0098813;GO:0010629;GO:1902680;GO:0006807;GO:0045944;GO:0048731;GO:0045934;GO:0048546;GO:0048736;GO:1902275;GO:1903508;GO:0007507;GO:0045778;GO:0045927;GO:0030326;GO:0031328;GO:0061458;GO:0031326;GO:0031325;GO:0031324;GO:0031323;GO:0010604;GO:1903047;GO:0090304;GO:0022402;GO:0035136;GO:0045444;GO:0007275;GO:0010628;GO:0040007;GO:0006325;GO:0040008;GO:2000112;GO:2000113;GO:0050789;GO:0071704;GO:0010467;GO:0006357;GO:0043583;GO:0009792;GO:0051173;GO:0010468;GO:0090596;GO:0048598;GO:0045935;GO:0000278;GO:0044267;GO:0051172;GO:0090312;GO:0048592;GO:0034613;GO:0042633;GO:0044767;GO:0022414;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0035112;GO:0035113;GO:0019222;GO:0048566;GO:0051179;GO:0061038;GO:0006996;GO:0009628;GO:0000070;GO:0051276;GO:0007399;GO:0031065;GO:0040018;GO:0048856;GO:0044237;GO:1903310;GO:1902589;GO:2000026;GO:0048285;GO:0061010;GO:0001654;GO:0048523;GO:0048522; ossification;positive regulation of developmental growth;protein localization;regulation of primary metabolic process;developmental growth;regulation of histone deacetylation;appendage morphogenesis;protein deacetylation;skeletal system development;circulatory system development;external genitalia morphogenesis;cranial skeletal system development;face development;multicellular organism growth;regulation of histone modification;positive regulation of histone modification;organic cyclic compound biosynthetic process;body morphogenesis;cellular component organization or biogenesis;outflow tract morphogenesis;histone deacetylation;cellular response to stimulus;negative regulation of macromolecule metabolic process;reproduction;cellular macromolecule localization;cellular developmental process;maintenance of sister chromatid cohesion;kidney development;regulation of organelle organization;regulation of protein metabolic process;animal organ development;maintenance of mitotic sister chromatid cohesion;positive regulation of biological process;genitalia development;tube morphogenesis;system process;histone modification;regulation of macromolecule metabolic process;sensory perception;heart morphogenesis;developmental process involved in reproduction;regulation of cellular protein metabolic process;regulation of embryonic development;regulation of RNA biosynthetic process;sensory perception of sound;heterocycle metabolic process;stem cell population maintenance;single organism reproductive process;single-multicellular organism process;cellular biosynthetic process;macromolecular complex subunit organization;positive regulation of organelle organization;head morphogenesis;protein metabolic process;cardiovascular system development;cellular response to stress;aromatic compound biosynthetic process;covalent chromatin modification;positive regulation of cellular component organization;regulation of RNA metabolic process;negative regulation of metabolic process;positive regulation of metabolic process;negative regulation of biosynthetic process;hepaticobiliary system development;embryonic organ development;limb development;positive regulation of RNA metabolic process;metabolic process;uterus development;mitotic sister chromatid cohesion;mitotic nuclear division;macromolecule metabolic process;nucleic acid-templated transcription;sister chromatid cohesion;head development;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;regulation of nucleobase-containing compound metabolic process;biological regulation;cell cycle;regulation of chromatin modification;transcription from RNA polymerase II promoter;cellular response to abiotic stimulus;regulation of protein deacetylation;digestive system development;heterocycle biosynthetic process;skeletal system morphogenesis;embryonic skeletal system morphogenesis;organ morphogenesis;embryonic skeletal system development;embryonic cranial skeleton morphogenesis;embryonic viscerocranium morphogenesis;nucleobase-containing compound metabolic process;regulation of developmental process;sensory perception of mechanical stimulus;positive regulation of multicellular organismal process;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;maintenance of cell number;response to stress;protein modification process;biological_process;cellular protein modification process;regulation of multicellular organismal process;face morphogenesis;nucleobase-containing compound biosynthetic process;chromosome segregation;regulation of ossification;molting cycle;RNA metabolic process;negative regulation of RNA biosynthetic process;sex differentiation;cellular nitrogen compound biosynthetic process;brain development;sensory organ development;embryonic forelimb morphogenesis;response to stimulus;positive regulation of protein modification process;cognition;macromolecule modification;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;embryonic digestive tract morphogenesis;positive regulation of chromosome organization;negative regulation of macromolecule biosynthetic process;regulation of chromosome organization;regulation of developmental growth;RNA biosynthetic process;cellular response to X-ray;response to radiation;cell differentiation;regulation of cellular component organization;limb morphogenesis;embryo development;cellular nitrogen compound metabolic process;embryonic organ morphogenesis;organic cyclic compound metabolic process;cellular macromolecule biosynthetic process;macromolecule deacylation;digestive tract development;anatomical structure morphogenesis;tube development;single-organism process;central nervous system development;response to X-ray;cellular response to ionizing radiation;cellular response to radiation;response to ionizing radiation;negative regulation of transcription from RNA polymerase II promoter;positive regulation of biosynthetic process;nuclear division;positive regulation of protein metabolic process;negative regulation of cellular biosynthetic process;chromatin modification;positive regulation of cellular protein metabolic process;regulation of protein modification process;chordate embryonic development;cellular localization;developmental process;ear morphogenesis;multicellular organismal process;reproductive structure development;protein deacylation;primary metabolic process;neurological system process;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;negative regulation of nucleic acid-templated transcription;cellular response to DNA damage stimulus;negative regulation of transcription, DNA-templated;urogenital system development;metanephros development;negative regulation of biological process;regulation of hair cycle;renal system development;regulation of multicellular organism growth;macromolecule localization;sister chromatid segregation;positive regulation of developmental process;positive regulation of transcription, DNA-templated;negative regulation of RNA metabolic process;nuclear chromosome segregation;negative regulation of gene expression;positive regulation of RNA biosynthetic process;nitrogen compound metabolic process;positive regulation of transcription from RNA polymerase II promoter;system development;negative regulation of nucleobase-containing compound metabolic process;digestive tract morphogenesis;appendage development;regulation of chromatin organization;positive regulation of nucleic acid-templated transcription;heart development;positive regulation of ossification;positive regulation of growth;embryonic limb morphogenesis;positive regulation of cellular biosynthetic process;reproductive system development;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;negative regulation of cellular metabolic process;regulation of cellular metabolic process;positive regulation of macromolecule metabolic process;mitotic cell cycle process;nucleic acid metabolic process;cell cycle process;forelimb morphogenesis;fat cell differentiation;multicellular organism development;positive regulation of gene expression;growth;chromatin organization;regulation of growth;regulation of cellular macromolecule biosynthetic process;negative regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;ear development;embryo development ending in birth or egg hatching;positive regulation of nitrogen compound metabolic process;regulation of gene expression;sensory organ morphogenesis;embryonic morphogenesis;positive regulation of nucleobase-containing compound metabolic process;mitotic cell cycle;cellular protein metabolic process;negative regulation of nitrogen compound metabolic process;positive regulation of protein deacetylation;eye morphogenesis;cellular protein localization;hair cycle;single-organism developmental process;reproductive process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;genitalia morphogenesis;embryonic appendage morphogenesis;regulation of metabolic process;embryonic digestive tract development;localization;uterus morphogenesis;organelle organization;response to abiotic stimulus;mitotic sister chromatid segregation;chromosome organization;nervous system development;positive regulation of histone deacetylation;positive regulation of multicellular organism growth;anatomical structure development;cellular metabolic process;positive regulation of chromatin modification;single-organism organelle organization;regulation of multicellular organismal development;organelle fission;gall bladder development;eye development;negative regulation of cellular process;positive regulation of cellular process; 4;4;4;4;3;6;4;8;5;5;5;4;4;4;5;5;5;4;2;4;5;3;4;2;4;4;5;4;5;5;4;6;2;4;4;3;4;4;5;5;3;5;5;6;7;4;4;3;3;4;4;5;4;4;5;4;5;7;4;5;3;3;4;5;4;5;5;2;4;6;5;4;7;5;4;4;4;3;5;2;4;7;7;4;7;5;5;5;6;4;6;5;5;4;3;6;3;4;3;3;3;3;5;1;6;3;4;5;4;4;4;5;6;4;5;4;4;7;2;6;5;5;6;5;5;6;6;6;5;6;4;6;7;4;5;4;5;5;4;5;4;5;6;4;3;4;2;5;6;6;5;5;7;4;6;5;5;6;5;6;7;3;2;6;2;4;7;3;4;2;4;7;7;5;6;5;5;2;4;5;4;3;5;3;6;5;5;5;6;3;7;4;5;5;4;6;7;4;4;3;6;5;5;5;4;4;4;4;5;5;4;6;6;4;5;2;5;3;6;6;2;3;5;7;5;6;4;5;5;4;5;5;5;4;7;6;5;5;3;2;3;5;3;4;4;5;3;5;2;4;4;3;6;5;5;6;4;3;3;7;4;4;5;4;5;3;3; GO:0031974;GO:0031981;GO:0043234;GO:0043230;GO:0043232;GO:0043233;GO:0043231;GO:0044428;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0043229;GO:0043228;GO:0043227;GO:0043226;GO:0005654;GO:0031982;GO:0044446;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0032116;GO:0005694;GO:0000785;GO:1903561;GO:0070062;GO:0032991;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;nuclear lumen;protein complex;extracellular organelle;intracellular non-membrane-bounded organelle;organelle lumen;intracellular membrane-bounded organelle;nuclear part;intracellular part;chromosomal part;extracellular region part;organelle part;intracellular organelle;non-membrane-bounded organelle;membrane-bounded organelle;organelle;nucleoplasm;vesicle;intracellular organelle part;nucleus;cell part;cell;intracellular;SMC loading complex;chromosome;chromatin;extracellular vesicle;extracellular exosome;macromolecular complex;cellular_component;intracellular organelle lumen;extracellular region; 2;5;3;3;4;3;4;4;3;4;2;2;3;3;3;2;5;4;3;5;2;2;3;4;5;3;3;4;2;1;4;2; GO:0044877;GO:0019904;GO:0003674;GO:0005488;GO:0042826;GO:0008022;GO:0019899;GO:0047485;GO:0005515;GO:0003682;GO:0070087; macromolecular complex binding;protein domain specific binding;molecular_function;binding;histone deacetylase binding;protein C-terminus binding;enzyme binding;protein N-terminus binding;protein binding;chromatin binding;chromo shadow domain binding; 3;4;1;2;5;4;4;4;3;4;5; K06672 map04111; Cell cycle - yeast; IPR033031;IPR024986;IPR016024;IPR011989;IPR026003; SCC2/Nipped-B family;Sister chromatid cohesion C-terminal domain;Armadillo-type fold;Armadillo-like helical;HEAT repeat associated with sister chromatid cohesion protein; plasma membrane Hs19718749 4692.0 BDL [B] Chromatin structure and dynamics;[D] Cell cycle control, cell division, chromosome partitioning;[L] Replication, recombination and repair; Q96HR3 Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1 - [MED30_HUMAN] nan nan nan nan nan nan nan nan nan nan nan nan nan nan GO:0080090;GO:0019222;GO:2001141;GO:0007165;GO:1901362;GO:1901360;GO:0009755;GO:0051716;GO:0010604;GO:0048518;GO:0006367;GO:0019827;GO:0060255;GO:0006366;GO:0030518;GO:0010033;GO:0046483;GO:0044700;GO:0044707;GO:0071407;GO:0019438;GO:0070887;GO:0009891;GO:0006807;GO:0050789;GO:0097659;GO:1901576;GO:0044260;GO:0065007;GO:0014070;GO:0018130;GO:0009889;GO:0071310;GO:0098727;GO:0008150;GO:0008152;GO:0034654;GO:0050794;GO:0016070;GO:0044271;GO:0050896;GO:0006355;GO:0043401;GO:0010556;GO:0006351;GO:0006352;GO:0032774;GO:0044249;GO:0034641;GO:0023052;GO:0034645;GO:0007154;GO:0044699;GO:0009893;GO:0009719;GO:0006139;GO:0031325;GO:0071495;GO:0032501;GO:0009987;GO:0071396;GO:1903506;GO:0032870;GO:0045893;GO:0009725;GO:0051252;GO:0051254;GO:0043170;GO:1902680;GO:0010628;GO:0048545;GO:0032502;GO:0031328;GO:0031326;GO:0071383;GO:0031323;GO:0090304;GO:0030522;GO:0030521;GO:0033993;GO:2000112;GO:0010557;GO:1903508;GO:0071704;GO:0010467;GO:0006357;GO:0010468;GO:0045935;GO:0019219;GO:0006725;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0042221;GO:0044238;GO:0044237;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;regulation of RNA biosynthetic process;signal transduction;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;hormone-mediated signaling pathway;cellular response to stimulus;positive regulation of macromolecule metabolic process;positive regulation of biological process;transcription initiation from RNA polymerase II promoter;stem cell population maintenance;regulation of macromolecule metabolic process;transcription from RNA polymerase II promoter;intracellular steroid hormone receptor signaling pathway;response to organic substance;heterocycle metabolic process;single organism signaling;single-multicellular organism process;cellular response to organic cyclic compound;aromatic compound biosynthetic process;cellular response to chemical stimulus;positive regulation of biosynthetic process;nitrogen compound metabolic process;regulation of biological process;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;biological regulation;response to organic cyclic compound;heterocycle biosynthetic process;regulation of biosynthetic process;cellular response to organic substance;maintenance of cell number;biological_process;metabolic process;nucleobase-containing compound biosynthetic process;regulation of cellular process;RNA metabolic process;cellular nitrogen compound biosynthetic process;response to stimulus;regulation of transcription, DNA-templated;steroid hormone mediated signaling pathway;regulation of macromolecule biosynthetic process;transcription, DNA-templated;DNA-templated transcription, initiation;RNA biosynthetic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;cellular macromolecule biosynthetic process;cell communication;single-organism process;positive regulation of metabolic process;response to endogenous stimulus;nucleobase-containing compound metabolic process;positive regulation of cellular metabolic process;cellular response to endogenous stimulus;multicellular organismal process;cellular process;cellular response to lipid;regulation of nucleic acid-templated transcription;cellular response to hormone stimulus;positive regulation of transcription, DNA-templated;response to hormone;regulation of RNA metabolic process;positive regulation of RNA metabolic process;macromolecule metabolic process;positive regulation of RNA biosynthetic process;positive regulation of gene expression;response to steroid hormone;developmental process;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;cellular response to steroid hormone stimulus;regulation of cellular metabolic process;nucleic acid metabolic process;intracellular receptor signaling pathway;androgen receptor signaling pathway;response to lipid;regulation of cellular macromolecule biosynthetic process;positive regulation of macromolecule biosynthetic process;positive regulation of nucleic acid-templated transcription;organic substance metabolic process;gene expression;regulation of transcription from RNA polymerase II promoter;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;regulation of nucleobase-containing compound metabolic process;cellular aromatic compound metabolic process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;response to chemical;primary metabolic process;cellular metabolic process;positive regulation of cellular process; 4;3;6;4;5;4;5;3;4;2;8;4;4;7;6;4;4;3;3;6;5;4;4;3;2;7;4;4;2;5;5;4;5;3;1;2;5;3;5;5;2;6;6;5;6;7;6;4;4;2;5;4;2;3;3;4;4;4;2;2;6;7;5;6;4;5;5;4;6;5;5;2;5;5;6;4;5;5;7;5;6;5;7;3;5;7;5;5;5;4;3;3;5;3;4;4;3;3;3;3; GO:0031974;GO:0016592;GO:0031981;GO:1990234;GO:0043234;GO:0043231;GO:0043233;GO:0000151;GO:0044428;GO:0044424;GO:0044422;GO:0043229;GO:0005622;GO:0043227;GO:0005654;GO:0044446;GO:0005634;GO:0044451;GO:0044464;GO:0005623;GO:1902494;GO:0043226;GO:0032991;GO:0005575;GO:0070013; membrane-enclosed lumen;mediator complex;nuclear lumen;transferase complex;protein complex;intracellular membrane-bounded organelle;organelle lumen;ubiquitin ligase complex;nuclear part;intracellular part;organelle part;intracellular organelle;intracellular;membrane-bounded organelle;nucleoplasm;intracellular organelle part;nucleus;nucleoplasm part;cell part;cell;catalytic complex;organelle;macromolecular complex;cellular_component;intracellular organelle lumen; 2;4;5;5;3;4;3;4;4;3;2;3;3;3;5;3;5;5;2;2;4;2;2;1;4; GO:0060089;GO:0001076;GO:0003713;GO:0003712;GO:0016740;GO:0061659;GO:0046966;GO:0003674;GO:0005488;GO:0000989;GO:0000988;GO:0019787;GO:0035257;GO:0004842;GO:0003824;GO:0030374;GO:0042809;GO:0008134;GO:0001104;GO:0051427;GO:0005515;GO:0005102;GO:0004872;GO:0061630; molecular transducer activity;transcription factor activity, RNA polymerase II transcription factor binding;transcription coactivator activity;transcription cofactor activity;transferase activity;ubiquitin-like protein ligase activity;thyroid hormone receptor binding;molecular_function;binding;transcription factor activity, transcription factor binding;transcription factor activity, protein binding;ubiquitin-like protein transferase activity;nuclear hormone receptor binding;ubiquitin-protein transferase activity;catalytic activity;ligand-dependent nuclear receptor transcription coactivator activity;vitamin D receptor binding;transcription factor binding;RNA polymerase II transcription cofactor activity;hormone receptor binding;protein binding;receptor binding;receptor activity;ubiquitin protein ligase activity; 2;4;5;4;3;5;5;1;2;3;2;4;6;5;2;6;5;4;5;5;3;4;3;6; K15143 map04919; Thyroid hormone signaling pathway; IPR021019; Mediator complex, subunit Med30, metazoa; cytosol Q6AI08 HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1 - [HEAT6_HUMAN] 0.932 0.934 1.251 1.093 0.988 0.872 0.997858672 nan 1.106275304 nan 1.339400428 nan 0.882591093 nan GO:0097159;GO:0044822;GO:0003674;GO:0003723;GO:0003676;GO:1901363;GO:0005488; organic cyclic compound binding;poly(A) RNA binding;molecular_function;RNA binding;nucleic acid binding;heterocyclic compound binding;binding; 3;6;1;5;4;3;2; IPR025283;IPR016024;IPR011989; Domain of unknown function DUF4042;Armadillo-type fold;Armadillo-like helical; nucleus Hs21361897 2065.0 R [R] General function prediction only; Q9H2P0 Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1 - [ADNP_HUMAN] 0.776 1.803 0.86 0.785 0.728 1.962 0.430393788 nan 1.078296703 nan 0.476982806 nan 2.695054945 nan GO:0009165;GO:0044281;GO:0051716;GO:0048589;GO:0018212;GO:0009190;GO:1990138;GO:0060548;GO:0045859;GO:0008361;GO:0046483;GO:0042325;GO:0042327;GO:0009605;GO:0019538;GO:0042698;GO:0009892;GO:0009893;GO:0009891;GO:0031175;GO:0050789;GO:0032091;GO:0000904;GO:0051347;GO:0000902;GO:0045981;GO:1901360;GO:0018130;GO:0009260;GO:0043412;GO:0043413;GO:0044723;GO:0000003;GO:0016070;GO:0010556;GO:1901293;GO:0043393;GO:0006753;GO:0010559;GO:0048639;GO:0048638;GO:0051128;GO:1901566;GO:0030810;GO:0050877;GO:0001558;GO:0010675;GO:0007409;GO:0045927;GO:0030030;GO:0046390;GO:0018108;GO:0042592;GO:0008219;GO:0007275;GO:0006486;GO:2000112;GO:0043067;GO:0043066;GO:0043069;GO:0006468;GO:0019219;GO:0070085;GO:0006464;GO:0044767;GO:0044763;GO:1901700;GO:0048858;GO:0048856;GO:0019693;GO:0006796;GO:2000026;GO:0006793;GO:0006140;GO:0048523;GO:0048522;GO:0048675;GO:0007614;GO:0007613;GO:0007610;GO:0007611;GO:0043523;GO:0043524;GO:0031344;GO:0031346;GO:0044710;GO:0044711;GO:0052652;GO:0045664;GO:0045666;GO:0044093;GO:0030307;GO:2001141;GO:0010035;GO:0010033;GO:0031668;GO:0023057;GO:1900373;GO:1900371;GO:0050730;GO:0010629;GO:0006807;GO:0044267;GO:0010646;GO:0044262;GO:0044260;GO:0070997;GO:0043085;GO:0050793;GO:0050790;GO:0009889;GO:0050794;GO:0051239;GO:1901214;GO:1901215;GO:0090407;GO:0050896;GO:0050890;GO:0051338;GO:0051963;GO:0051962;GO:0051960;GO:0051965;GO:0006109;GO:0010562;GO:0009259;GO:0044699;GO:0050767;GO:0051240;GO:0022603;GO:0051246;GO:0051247;GO:0050769;GO:0010769;GO:0031399;GO:0048609;GO:0030808;GO:1901137;GO:0030804;GO:1901135;GO:0030801;GO:0030802;GO:0048731;GO:0072521;GO:0072522;GO:0009100;GO:0009101;GO:0045935;GO:0030182;GO:0022414;GO:0007268;GO:0007267;GO:0042221;GO:0022008;GO:0044238;GO:0005975;GO:0009743;GO:0044237;GO:0019220;GO:0019222;GO:0048588;GO:0006471;GO:0048468;GO:1901362;GO:0071840;GO:0048869;GO:0048511;GO:0010720;GO:0048518;GO:0048519;GO:0032147;GO:0003008;GO:0044700;GO:0044702;GO:1901564;GO:0044707;GO:0050731;GO:0044708;GO:0098916;GO:0019637;GO:0032535;GO:0022604;GO:0022607;GO:0033674;GO:0051100;GO:0043170;GO:0042981;GO:0097659;GO:0043549;GO:0090066;GO:0061564;GO:0012501;GO:0034654;GO:0006182;GO:0044271;GO:0031401;GO:0006355;GO:0006351;GO:0099536;GO:0099537;GO:0032774;GO:0030154;GO:0060049;GO:0032270;GO:0060560;GO:0032502;GO:0032501;GO:0032504;GO:0009987;GO:0006725;GO:1903506;GO:0030799;GO:0050770;GO:0050772;GO:0051252;GO:0044849;GO:0010770;GO:0009187;GO:0032989;GO:0071704;GO:0048812;GO:0006915;GO:0051174;GO:0009058;GO:0009059;GO:0009117;GO:0051171;GO:0051173;GO:0080090;GO:0061387;GO:0010605;GO:0010604;GO:0018193;GO:0060255;GO:1903018;GO:0010976;GO:0010975;GO:0030516;GO:0048878;GO:0006163;GO:0060284;GO:0006164;GO:0019438;GO:1901576;GO:0016049;GO:0045937;GO:0016043;GO:0065007;GO:0065009;GO:0065008;GO:0051130;GO:0006139;GO:0009152;GO:0009150;GO:0036211;GO:0008150;GO:0008152;GO:0050808;GO:0050803;GO:0016310;GO:0050807;GO:0050805;GO:0050804;GO:0044249;GO:0034641;GO:0023052;GO:0010648;GO:0034645;GO:0023051;GO:0046068;GO:0009653;GO:0007416;GO:0048699;GO:0045597;GO:0045595;GO:0010835;GO:0055086;GO:1900544;GO:0032268;GO:0051094;GO:0051098;GO:0045860;GO:0009991;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:0090304;GO:0071496;GO:0010941;GO:0040007;GO:0040008;GO:0010467;GO:0044085;GO:0010468;GO:0048666;GO:0048667;GO:0033484;GO:0033483;GO:0051402;GO:0007154;GO:0044092;GO:0030826;GO:0030825;GO:1900542;GO:0030823;GO:0032990;GO:0007399;GO:0045773;GO:0030828;GO:0044087;GO:0001932;GO:0001934;GO:0044089; nucleotide biosynthetic process;small molecule metabolic process;cellular response to stimulus;developmental growth;peptidyl-tyrosine modification;cyclic nucleotide biosynthetic process;neuron projection extension;negative regulation of cell death;regulation of protein kinase activity;regulation of cell size;heterocycle metabolic process;regulation of phosphorylation;positive regulation of phosphorylation;response to external stimulus;protein metabolic process;ovulation cycle;negative regulation of metabolic process;positive regulation of metabolic process;positive regulation of biosynthetic process;neuron projection development;regulation of biological process;negative regulation of protein binding;cell morphogenesis involved in differentiation;positive regulation of transferase activity;cell morphogenesis;positive regulation of nucleotide metabolic process;organic cyclic compound metabolic process;heterocycle biosynthetic process;ribonucleotide biosynthetic process;macromolecule modification;macromolecule glycosylation;single-organism carbohydrate metabolic process;reproduction;RNA metabolic process;regulation of macromolecule biosynthetic process;nucleoside phosphate biosynthetic process;regulation of protein binding;nucleoside phosphate metabolic process;regulation of glycoprotein biosynthetic process;positive regulation of developmental growth;regulation of developmental growth;regulation of cellular component organization;organonitrogen compound biosynthetic process;positive regulation of nucleotide biosynthetic process;neurological system process;regulation of cell growth;regulation of cellular carbohydrate metabolic process;axonogenesis;positive regulation of growth;cell projection organization;ribose phosphate biosynthetic process;peptidyl-tyrosine phosphorylation;homeostatic process;cell death;multicellular organism development;protein glycosylation;regulation of cellular macromolecule biosynthetic process;regulation of programmed cell death;negative regulation of apoptotic process;negative regulation of programmed cell death;protein phosphorylation;regulation of nucleobase-containing compound metabolic process;glycosylation;cellular protein modification process;single-organism developmental process;single-organism cellular process;response to oxygen-containing compound;cell projection morphogenesis;anatomical structure development;ribose phosphate metabolic process;phosphate-containing compound metabolic process;regulation of multicellular organismal development;phosphorus metabolic process;regulation of nucleotide metabolic process;negative regulation of cellular process;positive regulation of cellular process;axon extension;short-term memory;memory;behavior;learning or memory;regulation of neuron apoptotic process;negative regulation of neuron apoptotic process;regulation of cell projection organization;positive regulation of cell projection organization;single-organism metabolic process;single-organism biosynthetic process;cyclic purine nucleotide metabolic process;regulation of neuron differentiation;positive regulation of neuron differentiation;positive regulation of molecular function;positive regulation of cell growth;regulation of RNA biosynthetic process;response to inorganic substance;response to organic substance;cellular response to extracellular stimulus;negative regulation of signaling;positive regulation of purine nucleotide biosynthetic process;regulation of purine nucleotide biosynthetic process;regulation of peptidyl-tyrosine phosphorylation;negative regulation of gene expression;nitrogen compound metabolic process;cellular protein metabolic process;regulation of cell communication;cellular carbohydrate metabolic process;cellular macromolecule metabolic process;neuron death;positive regulation of catalytic activity;regulation of developmental process;regulation of catalytic activity;regulation of biosynthetic process;regulation of cellular process;regulation of multicellular organismal process;regulation of neuron death;negative regulation of neuron death;organophosphate biosynthetic process;response to stimulus;cognition;regulation of transferase activity;regulation of synapse assembly;positive regulation of nervous system development;regulation of nervous system development;positive regulation of synapse assembly;regulation of carbohydrate metabolic process;positive regulation of phosphorus metabolic process;ribonucleotide metabolic process;single-organism process;regulation of neurogenesis;positive regulation of multicellular organismal process;regulation of anatomical structure morphogenesis;regulation of protein metabolic process;positive regulation of protein metabolic process;positive regulation of neurogenesis;regulation of cell morphogenesis involved in differentiation;regulation of protein modification process;multicellular organismal reproductive process;regulation of nucleotide biosynthetic process;carbohydrate derivative biosynthetic process;positive regulation of cyclic nucleotide biosynthetic process;carbohydrate derivative metabolic process;positive regulation of cyclic nucleotide metabolic process;regulation of cyclic nucleotide biosynthetic process;system development;purine-containing compound metabolic process;purine-containing compound biosynthetic process;glycoprotein metabolic process;glycoprotein biosynthetic process;positive regulation of nucleobase-containing compound metabolic process;neuron differentiation;reproductive process;synaptic transmission;cell-cell signaling;response to chemical;neurogenesis;primary metabolic process;carbohydrate metabolic process;response to carbohydrate;cellular metabolic process;regulation of phosphate metabolic process;regulation of metabolic process;developmental cell growth;protein ADP-ribosylation;cell development;organic cyclic compound biosynthetic process;cellular component organization or biogenesis;cellular developmental process;rhythmic process;positive regulation of cell development;positive regulation of biological process;negative regulation of biological process;activation of protein kinase activity;system process;single organism signaling;single organism reproductive process;organonitrogen compound metabolic process;single-multicellular organism process;positive regulation of peptidyl-tyrosine phosphorylation;single-organism behavior;anterograde trans-synaptic signaling;organophosphate metabolic process;regulation of cellular component size;regulation of cell morphogenesis;cellular component assembly;positive regulation of kinase activity;negative regulation of binding;macromolecule metabolic process;regulation of apoptotic process;nucleic acid-templated transcription;regulation of kinase activity;regulation of anatomical structure size;axon development;programmed cell death;nucleobase-containing compound biosynthetic process;cGMP biosynthetic process;cellular nitrogen compound biosynthetic process;positive regulation of protein modification process;regulation of transcription, DNA-templated;transcription, DNA-templated;synaptic signaling;trans-synaptic signaling;RNA biosynthetic process;cell differentiation;regulation of protein glycosylation;positive regulation of cellular protein metabolic process;developmental growth involved in morphogenesis;developmental process;multicellular organismal process;multicellular organism reproduction;cellular process;cellular aromatic compound metabolic process;regulation of nucleic acid-templated transcription;regulation of cyclic nucleotide metabolic process;regulation of axonogenesis;positive regulation of axonogenesis;regulation of RNA metabolic process;estrous cycle;positive regulation of cell morphogenesis involved in differentiation;cyclic nucleotide metabolic process;cellular component morphogenesis;organic substance metabolic process;neuron projection morphogenesis;apoptotic process;regulation of phosphorus metabolic process;biosynthetic process;macromolecule biosynthetic process;nucleotide metabolic process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;regulation of primary metabolic process;regulation of extent of cell growth;negative regulation of macromolecule metabolic process;positive regulation of macromolecule metabolic process;peptidyl-amino acid modification;regulation of macromolecule metabolic process;regulation of glycoprotein metabolic process;positive regulation of neuron projection development;regulation of neuron projection development;regulation of axon extension;chemical homeostasis;purine nucleotide metabolic process;regulation of cell development;purine nucleotide biosynthetic process;aromatic compound biosynthetic process;organic substance biosynthetic process;cell growth;positive regulation of phosphate metabolic process;cellular component organization;biological regulation;regulation of molecular function;regulation of biological quality;positive regulation of cellular component organization;nucleobase-containing compound metabolic process;purine ribonucleotide biosynthetic process;purine ribonucleotide metabolic process;protein modification process;biological_process;metabolic process;synapse organization;regulation of synapse structure or activity;phosphorylation;regulation of synapse organization;negative regulation of synaptic transmission;modulation of synaptic transmission;cellular biosynthetic process;cellular nitrogen compound metabolic process;signaling;negative regulation of cell communication;cellular macromolecule biosynthetic process;regulation of signaling;cGMP metabolic process;anatomical structure morphogenesis;synapse assembly;generation of neurons;positive regulation of cell differentiation;regulation of cell differentiation;regulation of protein ADP-ribosylation;nucleobase-containing small molecule metabolic process;positive regulation of purine nucleotide metabolic process;regulation of cellular protein metabolic process;positive regulation of developmental process;regulation of binding;positive regulation of protein kinase activity;response to extracellular stimulus;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;nucleic acid metabolic process;cellular response to external stimulus;regulation of cell death;growth;regulation of growth;gene expression;cellular component biogenesis;regulation of gene expression;neuron development;cell morphogenesis involved in neuron differentiation;nitric oxide homeostasis;gas homeostasis;neuron apoptotic process;cell communication;negative regulation of molecular function;regulation of cGMP biosynthetic process;positive regulation of cGMP metabolic process;regulation of purine nucleotide metabolic process;regulation of cGMP metabolic process;cell part morphogenesis;nervous system development;positive regulation of axon extension;positive regulation of cGMP biosynthetic process;regulation of cellular component biogenesis;regulation of protein phosphorylation;positive regulation of protein phosphorylation;positive regulation of cellular component biogenesis; 6;4;3;3;8;7;5;4;7;5;4;7;7;3;4;3;3;3;4;5;2;6;5;6;5;6;4;5;7;5;6;4;2;5;5;5;5;5;6;4;4;4;5;6;4;4;5;7;3;4;6;8;4;4;4;4;6;5;6;5;7;5;5;6;3;3;4;5;3;5;5;4;4;6;3;3;6;6;5;2;4;6;6;5;5;3;4;8;7;6;4;4;6;4;4;4;3;7;7;8;5;3;5;4;4;4;5;5;3;4;4;3;3;5;5;5;2;5;5;4;4;5;4;5;5;6;2;6;3;4;5;5;5;6;6;3;6;5;7;4;7;7;4;5;6;5;6;5;6;2;8;4;3;6;3;4;5;3;6;3;4;5;4;5;2;4;2;5;2;2;9;3;3;3;4;3;8;3;7;4;4;5;4;7;5;4;6;7;6;4;6;5;5;9;5;6;6;6;5;6;6;5;5;5;4;2;2;3;2;4;7;7;7;6;5;4;5;7;4;3;6;6;5;3;5;6;4;4;4;5;4;4;7;4;5;6;6;5;5;6;5;7;5;4;3;6;3;2;3;3;4;4;8;7;5;1;2;4;4;6;5;4;4;4;4;2;4;5;3;8;3;5;7;4;4;6;4;7;5;3;4;8;4;5;5;4;4;5;4;4;2;3;5;3;5;5;6;7;6;6;4;4;8;8;7;8;5;5;5;8;3;7;7;3; GO:0044424;GO:0044421;GO:0043025;GO:0044464;GO:0005615;GO:0044297;GO:0043231;GO:0043227;GO:0036477;GO:0043229;GO:0043226;GO:0005737;GO:0005634;GO:0043005;GO:0030425;GO:0030424;GO:0042995;GO:0005623;GO:0005622;GO:0097458;GO:0005575;GO:0005576; intracellular part;extracellular region part;neuronal cell body;cell part;extracellular space;cell body;intracellular membrane-bounded organelle;membrane-bounded organelle;somatodendritic compartment;intracellular organelle;organelle;cytoplasm;nucleus;neuron projection;dendrite;axon;cell projection;cell;intracellular;neuron part;cellular_component;extracellular region; 3;2;4;2;3;3;4;3;4;3;2;4;5;4;5;5;3;2;3;3;1;2; GO:0005488;GO:0005507;GO:0033218;GO:1901363;GO:0046872;GO:0003674;GO:0003676;GO:0003677;GO:0003682;GO:0097159;GO:0043169;GO:0042277;GO:0043167;GO:0046914;GO:0044877; binding;copper ion binding;amide binding;heterocyclic compound binding;metal ion binding;molecular_function;nucleic acid binding;DNA binding;chromatin binding;organic cyclic compound binding;cation binding;peptide binding;ion binding;transition metal ion binding;macromolecular complex binding; 2;7;3;3;5;1;4;5;4;3;4;4;3;6;3; K22591 IPR009057;IPR001356;IPR013083;IPR013087; Homeobox domain-like;Homeobox domain;Zinc finger, RING/FYVE/PHD-type;Zinc finger C2H2-type; nucleus Q9H3N8 Histamine H4 receptor OS=Homo sapiens OX=9606 GN=HRH4 PE=1 SV=2 - [HRH4_HUMAN] 1.004 1.133 0.832 1.249 1.114 0.817 0.886142983 nan 1.121184919 nan 0.734333628 nan 0.733393178 nan GO:0019220;GO:0080090;GO:0019222;GO:0048583;GO:0055074;GO:0098771;GO:0023014;GO:0051716;GO:0009966;GO:0007213;GO:0000165;GO:0019725;GO:0060255;GO:0010033;GO:0042325;GO:0044700;GO:0019538;GO:0007200;GO:0007204;GO:0007207;GO:0048878;GO:0098916;GO:0007165;GO:0023051;GO:0031399;GO:0035556;GO:0050789;GO:0044267;GO:0044260;GO:0098926;GO:0007188;GO:0065007;GO:0065008;GO:0007186;GO:0007187;GO:0044710;GO:0050794;GO:0006952;GO:1903831;GO:0006950;GO:1905145;GO:0008150;GO:0006954;GO:1902531;GO:0043412;GO:0050896;GO:1901699;GO:1905144;GO:0036211;GO:0044763;GO:0007193;GO:0007197;GO:0099537;GO:0008152;GO:0016310;GO:0050801;GO:0071242;GO:0023052;GO:0070887;GO:0042221;GO:0010646;GO:0044699;GO:0043408;GO:0072507;GO:0072503;GO:0051246;GO:0044238;GO:0006875;GO:0060359;GO:0009987;GO:0006873;GO:0030003;GO:0055080;GO:0055082;GO:0032268;GO:0043170;GO:0095500;GO:1901698;GO:0031323;GO:0042592;GO:0007271;GO:0006796;GO:0071704;GO:0006874;GO:0006468;GO:0006464;GO:0051174;GO:0007268;GO:0055065;GO:0007267;GO:0007154;GO:1901700;GO:1901701;GO:0051480;GO:0044237;GO:0099536;GO:0006793;GO:0001932; regulation of phosphate metabolic process;regulation of primary metabolic process;regulation of metabolic process;regulation of response to stimulus;calcium ion homeostasis;inorganic ion homeostasis;signal transduction by protein phosphorylation;cellular response to stimulus;regulation of signal transduction;G-protein coupled acetylcholine receptor signaling pathway;MAPK cascade;cellular homeostasis;regulation of macromolecule metabolic process;response to organic substance;regulation of phosphorylation;single organism signaling;protein metabolic process;phospholipase C-activating G-protein coupled receptor signaling pathway;positive regulation of cytosolic calcium ion concentration;phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway;chemical homeostasis;anterograde trans-synaptic signaling;signal transduction;regulation of signaling;regulation of protein modification process;intracellular signal transduction;regulation of biological process;cellular protein metabolic process;cellular macromolecule metabolic process;postsynaptic signal transduction;adenylate cyclase-modulating G-protein coupled receptor signaling pathway;biological regulation;regulation of biological quality;G-protein coupled receptor signaling pathway;G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;single-organism metabolic process;regulation of cellular process;defense response;signal transduction involved in cellular response to ammonium ion;response to stress;cellular response to acetylcholine;biological_process;inflammatory response;regulation of intracellular signal transduction;macromolecule modification;response to stimulus;cellular response to nitrogen compound;response to acetylcholine;protein modification process;single-organism cellular process;adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway;trans-synaptic signaling;metabolic process;phosphorylation;ion homeostasis;cellular response to ammonium ion;signaling;cellular response to chemical stimulus;response to chemical;regulation of cell communication;single-organism process;regulation of MAPK cascade;divalent inorganic cation homeostasis;cellular divalent inorganic cation homeostasis;regulation of protein metabolic process;primary metabolic process;cellular metal ion homeostasis;response to ammonium ion;cellular process;cellular ion homeostasis;cellular cation homeostasis;cation homeostasis;cellular chemical homeostasis;regulation of cellular protein metabolic process;macromolecule metabolic process;acetylcholine receptor signaling pathway;response to nitrogen compound;regulation of cellular metabolic process;homeostatic process;synaptic transmission, cholinergic;phosphate-containing compound metabolic process;organic substance metabolic process;cellular calcium ion homeostasis;protein phosphorylation;cellular protein modification process;regulation of phosphorus metabolic process;synaptic transmission;metal ion homeostasis;cell-cell signaling;cell communication;response to oxygen-containing compound;cellular response to oxygen-containing compound;regulation of cytosolic calcium ion concentration;cellular metabolic process;synaptic signaling;phosphorus metabolic process;regulation of protein phosphorylation; 6;4;3;3;9;7;4;3;4;6;5;4;4;4;7;3;4;6;11;7;5;7;4;3;6;5;2;5;4;5;7;2;3;5;6;3;3;4;5;3;6;1;5;5;5;2;5;5;5;3;8;7;6;2;6;6;6;2;4;3;4;2;6;8;8;5;3;8;5;2;6;7;7;5;5;4;6;4;4;4;9;5;3;9;7;6;5;8;8;4;4;4;5;10;3;5;4;7; GO:0016021;GO:0016020;GO:0044425;GO:0031224;GO:0005886;GO:0044464;GO:0005623;GO:0071944;GO:0045202;GO:0005575; integral component of membrane;membrane;membrane part;intrinsic component of membrane;plasma membrane;cell part;cell;cell periphery;synapse;cellular_component; 4;2;2;3;3;2;2;3;2;1; GO:0060089;GO:0030594;GO:0099600;GO:0015464;GO:0003674;GO:0004930;GO:0008227;GO:0016907;GO:0099528;GO:0004872;GO:0038023;GO:0004871;GO:0004969;GO:0004888; molecular transducer activity;neurotransmitter receptor activity;transmembrane receptor activity;acetylcholine receptor activity;molecular_function;G-protein coupled receptor activity;G-protein coupled amine receptor activity;G-protein coupled acetylcholine receptor activity;G-protein coupled neurotransmitter receptor activity;receptor activity;signaling receptor activity;signal transducer activity;histamine receptor activity;transmembrane signaling receptor activity; 2;4;4;5;1;5;6;6;5;3;3;2;7;4; K04152 map04080; Neuroactive ligand-receptor interaction; IPR000276;IPR008102;IPR017452; G protein-coupled receptor, rhodopsin-like;Histamine H4 receptor;GPCR, rhodopsin-like, 7TM; plasma membrane Hs14251205 795.0 R [R] General function prediction only; Q8WXA3 RUN and FYVE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RUFY2 PE=1 SV=3 - [RUFY2_HUMAN] 1.068 0.954 0.963 1.051 1.136 0.802 1.119496855 0.202068659 0.925176056 0.178100653 1.009433962 0.825338564 0.705985915 0.71938998 GO:0043231;GO:0005634;GO:0044464;GO:0005623;GO:0005622;GO:0005575;GO:0043229;GO:0044424;GO:0043227;GO:0043226; intracellular membrane-bounded organelle;nucleus;cell part;cell;intracellular;cellular_component;intracellular organelle;intracellular part;membrane-bounded organelle;organelle; 4;5;2;2;3;1;3;3;3;2; GO:0043169;GO:0043167;GO:0003674;GO:0005488;GO:0046872; cation binding;ion binding;molecular_function;binding;metal ion binding; 4;3;1;2;5; IPR011011;IPR000306;IPR017455;IPR013083;IPR004012; Zinc finger, FYVE/PHD-type;FYVE zinc finger;Zinc finger, FYVE-related;Zinc finger, RING/FYVE/PHD-type;RUN domain; cytosol Hs7662352 501.0 T [T] Signal transduction mechanisms; P12004 Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1 - [PCNA_HUMAN] 1.422 1.13 0.359 1.544 1.084 0.523 1.25840708 nan 1.424354244 nan 0.317699115 nan 0.482472325 nan GO:0080090;GO:0019222;GO:0060249;GO:0060429;GO:0048584;GO:0000082;GO:0000083;GO:0072359;GO:0072358;GO:0042769;GO:1901362;GO:1901360;GO:0051716;GO:0044711;GO:0010604;GO:0048869;GO:0070647;GO:0018193;GO:0032446;GO:0006260;GO:0006261;GO:0030855;GO:0048518;GO:0031297;GO:0051345;GO:0019725;GO:0006284;GO:0051054;GO:0006282;GO:0006283;GO:0006281;GO:0060255;GO:0048583;GO:0006289;GO:0042221;GO:0010038;GO:2001141;GO:2001020;GO:0010035;GO:0010033;GO:0046483;GO:0071214;GO:0019538;GO:0006271;GO:0019985;GO:0006275;GO:0070987;GO:0018205;GO:0033554;GO:0006272;GO:0019438;GO:0044786;GO:0006297;GO:0044707;GO:0009893;GO:0009891;GO:0006298;GO:0006807;GO:0070911;GO:0097659;GO:1901576;GO:0044260;GO:0016043;GO:0065007;GO:0071840;GO:0065009;GO:0065008;GO:0018130;GO:0000722;GO:0032070;GO:0050790;GO:0009889;GO:0044710;GO:0050794;GO:0006950;GO:0036211;GO:0008150;GO:0008152;GO:0048731;GO:0034654;GO:0032075;GO:0006310;GO:0051336;GO:0044271;GO:0006301;GO:0043412;GO:0050896;GO:0080135;GO:0000731;GO:0033260;GO:0006355;GO:0010557;GO:0010556;GO:0006351;GO:0045739;GO:0032069;GO:2001022;GO:0071482;GO:0032774;GO:0043085;GO:0009314;GO:0030154;GO:0016070;GO:1902990;GO:0044249;GO:0034641;GO:0009411;GO:0009416;GO:0034645;GO:0034644;GO:0044699;GO:0000723;GO:0006139;GO:0071478;GO:0042276;GO:0033683;GO:0048513;GO:0045740;GO:0022616;GO:0032502;GO:0045005;GO:0032501;GO:0044093;GO:0009628;GO:0043687;GO:0009987;GO:0006725;GO:0006974;GO:0032077;GO:1903506;GO:0010833;GO:0051606;GO:0016925;GO:0042592;GO:0007049;GO:0051252;GO:0043170;GO:0080134;GO:0071897;GO:0007507;GO:0031328;GO:0031326;GO:0031325;GO:0031323;GO:1903047;GO:0090304;GO:0090305;GO:0044772;GO:0022402;GO:0044237;GO:0007275;GO:0051052;GO:0009888;GO:0008283;GO:2000112;GO:0050789;GO:0071704;GO:0010467;GO:0046686;GO:0010468;GO:0045935;GO:0000278;GO:0044267;GO:0019219;GO:0006464;GO:0044767;GO:0009058;GO:0009059;GO:0044763;GO:0051171;GO:0051173;GO:0044843;GO:0006996;GO:0044238;GO:0006312;GO:0051276;GO:0048856;GO:0032201;GO:0032200;GO:0044770;GO:1902589;GO:0033993;GO:0006259;GO:0048522; regulation of primary metabolic process;regulation of metabolic process;anatomical structure homeostasis;epithelium development;positive regulation of response to stimulus;G1/S transition of mitotic cell cycle;regulation of transcription involved in G1/S transition of mitotic cell cycle;circulatory system development;cardiovascular system development;DNA damage response, detection of DNA damage;organic cyclic compound biosynthetic process;organic cyclic compound metabolic process;cellular response to stimulus;single-organism biosynthetic process;positive regulation of macromolecule metabolic process;cellular developmental process;protein modification by small protein conjugation or removal;peptidyl-amino acid modification;protein modification by small protein conjugation;DNA replication;DNA-dependent DNA replication;epithelial cell differentiation;positive regulation of biological process;replication fork processing;positive regulation of hydrolase activity;cellular homeostasis;base-excision repair;positive regulation of DNA metabolic process;regulation of DNA repair;transcription-coupled nucleotide-excision repair;DNA repair;regulation of macromolecule metabolic process;regulation of response to stimulus;nucleotide-excision repair;response to chemical;response to metal ion;regulation of RNA biosynthetic process;regulation of response to DNA damage stimulus;response to inorganic substance;response to organic substance;heterocycle metabolic process;cellular response to abiotic stimulus;protein metabolic process;DNA strand elongation involved in DNA replication;translesion synthesis;regulation of DNA replication;error-free translesion synthesis;peptidyl-lysine modification;cellular response to stress;leading strand elongation;aromatic compound biosynthetic process;cell cycle DNA replication;nucleotide-excision repair, DNA gap filling;single-multicellular organism process;positive regulation of metabolic process;positive regulation of biosynthetic process;mismatch repair;nitrogen compound metabolic process;global genome nucleotide-excision repair;nucleic acid-templated transcription;organic substance biosynthetic process;cellular macromolecule metabolic process;cellular component organization;biological regulation;cellular component organization or biogenesis;regulation of molecular function;regulation of biological quality;heterocycle biosynthetic process;telomere maintenance via recombination;regulation of deoxyribonuclease activity;regulation of catalytic activity;regulation of biosynthetic process;single-organism metabolic process;regulation of cellular process;response to stress;protein modification process;biological_process;metabolic process;system development;nucleobase-containing compound biosynthetic process;positive regulation of nuclease activity;DNA recombination;regulation of hydrolase activity;cellular nitrogen compound biosynthetic process;postreplication repair;macromolecule modification;response to stimulus;regulation of cellular response to stress;DNA synthesis involved in DNA repair;nuclear DNA replication;regulation of transcription, DNA-templated;positive regulation of macromolecule biosynthetic process;regulation of macromolecule biosynthetic process;transcription, DNA-templated;positive regulation of DNA repair;regulation of nuclease activity;positive regulation of response to DNA damage stimulus;cellular response to light stimulus;RNA biosynthetic process;positive regulation of catalytic activity;response to radiation;cell differentiation;RNA metabolic process;mitotic telomere maintenance via semi-conservative replication;cellular biosynthetic process;cellular nitrogen compound metabolic process;response to UV;response to light stimulus;cellular macromolecule biosynthetic process;cellular response to UV;single-organism process;telomere maintenance;nucleobase-containing compound metabolic process;cellular response to radiation;error-prone translesion synthesis;nucleotide-excision repair, DNA incision;animal organ development;positive regulation of DNA replication;DNA strand elongation;developmental process;DNA-dependent DNA replication maintenance of fidelity;multicellular organismal process;positive regulation of molecular function;response to abiotic stimulus;post-translational protein modification;cellular process;cellular aromatic compound metabolic process;cellular response to DNA damage stimulus;positive regulation of deoxyribonuclease activity;regulation of nucleic acid-templated transcription;telomere maintenance via telomere lengthening;detection of stimulus;protein sumoylation;homeostatic process;cell cycle;regulation of RNA metabolic process;macromolecule metabolic process;regulation of response to stress;DNA biosynthetic process;heart development;positive regulation of cellular biosynthetic process;regulation of cellular biosynthetic process;positive regulation of cellular metabolic process;regulation of cellular metabolic process;mitotic cell cycle process;nucleic acid metabolic process;nucleic acid phosphodiester bond hydrolysis;mitotic cell cycle phase transition;cell cycle process;cellular metabolic process;multicellular organism development;regulation of DNA metabolic process;tissue development;cell proliferation;regulation of cellular macromolecule biosynthetic process;regulation of biological process;organic substance metabolic process;gene expression;response to cadmium ion;regulation of gene expression;positive regulation of nucleobase-containing compound metabolic process;mitotic cell cycle;cellular protein metabolic process;regulation of nucleobase-containing compound metabolic process;cellular protein modification process;single-organism developmental process;biosynthetic process;macromolecule biosynthetic process;single-organism cellular process;regulation of nitrogen compound metabolic process;positive regulation of nitrogen compound metabolic process;cell cycle G1/S phase transition;organelle organization;primary metabolic process;mitotic recombination;chromosome organization;anatomical structure development;telomere maintenance via semi-conservative replication;telomere organization;cell cycle phase transition;single-organism organelle organization;response to lipid;DNA metabolic process;positive regulation of cellular process; 4;3;5;5;3;7;6;5;5;4;5;4;3;4;4;4;7;7;8;6;7;6;2;4;6;4;5;5;5;6;4;4;3;5;3;5;6;5;4;4;4;4;4;7;5;6;6;8;4;6;5;5;6;3;3;4;5;3;6;7;4;4;3;2;2;3;3;5;5;6;4;4;3;3;3;5;1;2;4;5;5;6;5;5;5;5;2;4;5;5;6;5;5;6;5;5;4;6;6;5;4;5;5;6;4;4;6;5;5;7;2;4;4;5;6;6;4;6;6;2;6;2;4;3;7;2;4;5;6;7;5;3;9;4;4;5;4;4;6;4;5;5;4;4;5;5;6;6;4;3;4;5;4;3;6;2;3;5;6;5;5;5;5;5;6;3;3;5;3;4;4;6;4;3;7;5;3;5;6;5;4;5;5;3; GO:0031974;GO:0005815;GO:0031981;GO:0005657;GO:0043626;GO:0043234;GO:0043230;GO:0043231;GO:0043232;GO:0043233;GO:0005663;GO:0044428;GO:0044424;GO:0044427;GO:0044421;GO:0044422;GO:0000781;GO:0043229;GO:0000228;GO:0005622;GO:0043227;GO:0043226;GO:0005856;GO:0005654;GO:0044430;GO:0005737;GO:0030894;GO:0098687;GO:0031982;GO:0005634;GO:0044454;GO:0044796;GO:0044464;GO:0005623;GO:0043228;GO:0000784;GO:0044446;GO:0070062;GO:0070557;GO:0005813;GO:0043596;GO:0005694;GO:0015630;GO:1903561;GO:0032991;GO:0032993;GO:0005575;GO:0070013;GO:0005576; membrane-enclosed lumen;microtubule organizing center;nuclear lumen;replication fork;PCNA complex;protein complex;extracellular organelle;intracellular membrane-bounded organelle;intracellular non-membrane-bounded organelle;organelle lumen;DNA replication factor C complex;nuclear part;intracellular part;chromosomal part;extracellular region part;organelle part;chromosome, telomeric region;intracellular organelle;nuclear chromosome;intracellular;membrane-bounded organelle;organelle;cytoskeleton;nucleoplasm;cytoskeletal part;cytoplasm;replisome;chromosomal region;vesicle;nucleus;nuclear chromosome part;DNA polymerase processivity factor complex;cell part;cell;non-membrane-bounded organelle;nuclear chromosome, telomeric region;intracellular organelle part;extracellular exosome;PCNA-p21 complex;centrosome;nuclear replication fork;chromosome;microtubule cytoskeleton;extracellular vesicle;macromolecular complex;protein-DNA complex;cellular_component;intracellular organelle lumen;extracellular region; 2;5;5;5;5;3;3;4;4;3;4;4;3;4;2;2;6;3;5;3;3;2;5;5;4;4;4;5;4;5;5;4;2;2;3;6;3;4;4;5;6;5;6;3;2;3;1;4;2; GO:1901363;GO:0032139;GO:0032135;GO:0019901;GO:0019900;GO:1990782;GO:0003674;GO:0005488;GO:0003677;GO:0070182;GO:0098772;GO:0000701;GO:0000700;GO:0030971;GO:0003824;GO:0003682;GO:0097159;GO:0003684;GO:0016799;GO:0019899;GO:0032403;GO:0003690;GO:0032405;GO:0032404;GO:0035035;GO:0016787;GO:0042802;GO:0005515;GO:0044877;GO:0005102;GO:0016798;GO:0003676;GO:0030983;GO:0030337;GO:0030234;GO:0019104; heterocyclic compound binding;dinucleotide insertion or deletion binding;DNA insertion or deletion binding;protein kinase binding;kinase binding;protein tyrosine kinase binding;molecular_function;binding;DNA binding;DNA polymerase binding;molecular function regulator;purine-specific mismatch base pair DNA N-glycosylase activity;mismatch base pair DNA N-glycosylase activity;receptor tyrosine kinase binding;catalytic activity;chromatin binding;organic cyclic compound binding;damaged DNA binding;hydrolase activity, hydrolyzing N-glycosyl compounds;enzyme binding;protein complex binding;double-stranded DNA binding;MutLalpha complex binding;mismatch repair complex binding;histone acetyltransferase binding;hydrolase activity;identical protein binding;protein binding;macromolecular complex binding;receptor binding;hydrolase activity, acting on glycosyl bonds;nucleic acid binding;mismatched DNA binding;DNA polymerase processivity factor activity;enzyme regulator activity;DNA N-glycosylase activity; 3;9;8;6;5;7;1;2;5;5;2;8;7;5;2;4;3;6;5;4;4;6;6;5;5;3;4;3;3;4;4;4;7;4;3;6; K04802 map03030;map03410;map03420;map03430;map04110;map05161;map05166; DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Cell cycle;Hepatitis B;HTLV-I infection; IPR022648;IPR022649;IPR000730;IPR022659; Proliferating cell nuclear antigen, PCNA, N-terminal;Proliferating cell nuclear antigen, PCNA, C-terminal;Proliferating cell nuclear antigen, PCNA;Proliferating cell nuclear antigen, PCNA, conserved site; cytosol Hs4505641 537.0 L [L] Replication, recombination and repair; Q9BTE3 Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2 - [MCMBP_HUMAN] 0.449 0.638 2.599 0.563 0.71 0.464 0.703761755 nan 0.792957746 nan 4.073667712 nan 0.653521127 nan GO:0090304;GO:0044249;GO:0034641;GO:0006807;GO:0022402;GO:0044237;GO:0034645;GO:0071840;GO:1901576;GO:0007067;GO:0043170;GO:1901360;GO:0007062;GO:0000280;GO:0016043;GO:0071704;GO:0006260;GO:0006261;GO:0051301;GO:0000278;GO:0006139;GO:0007049;GO:0009987;GO:0006725;GO:0044260;GO:0006259;GO:0009058;GO:0009059;GO:0008150;GO:1903047;GO:0008152;GO:0007059;GO:0046483;GO:0006996;GO:0044238;GO:0044699;GO:0000819;GO:0098813;GO:1902589;GO:0048285;GO:0044763;GO:0051276; nucleic acid metabolic process;cellular biosynthetic process;cellular nitrogen compound metabolic process;nitrogen compound metabolic process;cell cycle process;cellular metabolic process;cellular macromolecule biosynthetic process;cellular component organization or biogenesis;organic substance biosynthetic process;mitotic nuclear division;macromolecule metabolic process;organic cyclic compound metabolic process;sister chromatid cohesion;nuclear division;cellular component organization;organic substance metabolic process;DNA replication;DNA-dependent DNA replication;cell division;mitotic cell cycle;nucleobase-containing compound metabolic process;cell cycle;cellular process;cellular aromatic compound metabolic process;cellular macromolecule metabolic process;DNA metabolic process;biosynthetic process;macromolecule biosynthetic process;biological_process;mitotic cell cycle process;metabolic process;chromosome segregation;heterocycle metabolic process;organelle organization;primary metabolic process;single-organism process;sister chromatid segregation;nuclear chromosome segregation;single-organism organelle organization;organelle fission;single-organism cellular process;chromosome organization; 5;4;4;3;4;3;5;2;4;5;4;4;5;6;3;3;6;7;4;5;4;4;2;4;4;5;3;5;1;5;2;4;4;4;3;2;5;5;4;5;3;5; GO:0031974;GO:0043227;GO:0043226;GO:0005737;GO:0005575;GO:0031981;GO:0005634;GO:0016020;GO:0005654;GO:0005886;GO:0043231;GO:0043233;GO:0044464;GO:0043229;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0071944;GO:0044428;GO:0044424;GO:0044422; membrane-enclosed lumen;membrane-bounded organelle;organelle;cytoplasm;cellular_component;nuclear lumen;nucleus;membrane;nucleoplasm;plasma membrane;intracellular membrane-bounded organelle;organelle lumen;cell part;intracellular organelle;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cell periphery;nuclear part;intracellular part;organelle part; 2;3;2;4;1;5;5;2;5;3;4;3;2;3;2;3;3;4;3;4;3;2; GO:0003674;GO:0044877;GO:0003682;GO:0005488; molecular_function;macromolecular complex binding;chromatin binding;binding; 1;3;4;2; IPR019140; Mini-chromosome maintenance complex-binding protein; cytosol Hs13376243 1335.0 S [S] Function unknown; Q6P2I3 Fumarylacetoacetate hydrolase domain-containing protein 2B OS=Homo sapiens OX=9606 GN=FAHD2B PE=1 SV=1 - [FAH2B_HUMAN] 1.281 1.092 0.71 1.168 1.083 0.763 1.173076923 nan 1.078485688 nan 0.65018315 nan 0.704524469 nan GO:0016787;GO:0043169;GO:0043167;GO:0003824;GO:0003674;GO:0005488;GO:0046872; hydrolase activity;cation binding;ion binding;catalytic activity;molecular_function;binding;metal ion binding; 3;4;3;2;1;2;5; IPR011234; Fumarylacetoacetase, C-terminal-related; mitochondria Hs13637384 645.0 R [R] General function prediction only; Q9NQ94 APOBEC1 complementation factor OS=Homo sapiens OX=9606 GN=A1CF PE=1 SV=1 - [A1CF_HUMAN] 0.731 0.824 1.785 0.825 0.865 0.93 0.887135922 nan 0.953757225 nan 2.166262136 nan 1.075144509 nan GO:0016554;GO:0009451;GO:0050821;GO:0006807;GO:0044237;GO:0043170;GO:1901360;GO:0090304;GO:0044260;GO:0016556;GO:0016071;GO:0016553;GO:0071704;GO:0010467;GO:0065007;GO:0065008;GO:0016070;GO:0006139;GO:0009987;GO:0006725;GO:0043412;GO:0008150;GO:0008152;GO:0006396;GO:0046483;GO:0044238;GO:0031647;GO:0034641;GO:0006397; cytidine to uridine editing;RNA modification;protein stabilization;nitrogen compound metabolic process;cellular metabolic process;macromolecule metabolic process;organic cyclic compound metabolic process;nucleic acid metabolic process;cellular macromolecule metabolic process;mRNA modification;mRNA metabolic process;base conversion or substitution editing;organic substance metabolic process;gene expression;biological regulation;regulation of biological quality;RNA metabolic process;nucleobase-containing compound metabolic process;cellular process;cellular aromatic compound metabolic process;macromolecule modification;biological_process;metabolic process;RNA processing;heterocycle metabolic process;primary metabolic process;regulation of protein stability;cellular nitrogen compound metabolic process;mRNA processing; 8;6;5;3;3;4;4;5;4;7;6;7;3;5;2;3;5;4;2;4;5;1;2;6;4;3;4;4;7; GO:0005783;GO:0031974;GO:0043229;GO:0043227;GO:0043226;GO:0005737;GO:0005575;GO:0005634;GO:0005654;GO:0030895;GO:0031981;GO:0012505;GO:0043234;GO:0032991;GO:0043231;GO:0043233;GO:0044464;GO:0005623;GO:0005622;GO:0044446;GO:0070013;GO:0044444;GO:0044428;GO:0044424;GO:0044422; endoplasmic reticulum;membrane-enclosed lumen;intracellular organelle;membrane-bounded organelle;organelle;cytoplasm;cellular_component;nucleus;nucleoplasm;apolipoprotein B mRNA editing enzyme complex;nuclear lumen;endomembrane system;protein complex;macromolecular complex;intracellular membrane-bounded organelle;organelle lumen;cell part;cell;intracellular;intracellular organelle part;intracellular organelle lumen;cytoplasmic part;nuclear part;intracellular part;organelle part; 4;2;3;3;2;4;1;5;5;4;5;3;3;2;4;3;2;2;3;3;4;4;4;3;2; GO:1901363;GO:0003674;GO:0003676;GO:0003727;GO:0000166;GO:1901265;GO:0036094;GO:0097159;GO:0003723;GO:0005488; heterocyclic compound binding;molecular_function;nucleic acid binding;single-stranded RNA binding;nucleotide binding;nucleoside phosphate binding;small molecule binding;organic cyclic compound binding;RNA binding;binding; 3;1;4;6;4;4;3;3;5;2; IPR034539;IPR034538;IPR000504;IPR006535;IPR033111; ACF, RNA recognition motif 3;ACF, RNA recognition motif 1;RNA recognition motif domain;HnRNP R/Q splicing factor;APOBEC1 complementation factor; nucleus Hs20357575 1228.0 A [A] RNA processing and modification;