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{"sheet":"耐药基因预测详情表","index":0,"n_rows":181,"n_cols":13,"rows_kept":181}
["Gene ID","Location","Sample Name","ARO Name","ARO Accession","ARO Description","ARO Category","Drug Class","Resistance Mechanism","Identity(%)","Coverage(%)","Evalue","Score"]
["gene0004","Chr1","SMVS","Escherichia coli gyrB conferring resistance to aminocoumarin","ARO:3003303","Point mutation in Escherichia coli resulting in aminocoumarin resistance","aminocoumarin resistance gene;antibiotic resistant gene variant or mutant","-","-",77.5,100,0,3256]
["gene0014","Chr1","SMVS","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","diaminopyrimidine antibiotic;fluoroquinolone antibiotic;phenicol antibiotic","antibiotic efflux",35.5,92.1,8.7e-40,397]
["gene0055","Chr1","SMVS","arlR","ARO:3000838","ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","acridine dye;fluoroquinolone antibiotic","antibiotic efflux",30.6,25.9,3e-12,161]
["gene0056","Chr1","SMVS","vanSF","ARO:3002936","vanSF is a vanS variant found in the vanF gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",27.6,71.1,2e-13,170]
["gene0058","Chr1","SMVS","tetB(P)","ARO:3000195","TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P)","antibiotic target protection protein;tetracycline resistance gene","tetracycline antibiotic","antibiotic target protection",34.5,32.6,2.3e-28,301]
["gene0082","Chr1","SMVS","cpxA","ARO:3000830","CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;aminoglycoside antibiotic","antibiotic efflux",28.6,72.1,1.9e-29,309]
["gene0083","Chr1","SMVS","vanRI","ARO:3003728","VanRI is the regulatory transcriptional activator in the VanSR regulator within the VanI glycopeptide resistance gene cluster.","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",39.1,93.7,4.4e-44,433]
["gene0109","Chr1","SMVS","mfd","ARO:3003844","mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein","antibiotic target protection protein;fluoroquinolone resistance gene","-","-",39,54.5,1.3E-64,614]
["gene0144","Chr1","SMVS","PmrE","ARO:3003577","PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A","polymyxin resistance gene;gene altering cell wall charge conferring antibiotic resistance","peptide antibiotic","antibiotic target alteration",73.5,100,6.1e-168,1503]
["gene0215","Chr1","SMVS","Streptococcus pneumoniae PBP1a conferring resistance to amoxicillin","ARO:3003041","PBP1a is a penicillin-binding protein found in Streptococcus pneumoniae","antibiotic resistant gene variant or mutant;beta-lactam resistance gene","carbapenem;cephalosporin;cephamycin;monobactam;penam","antibiotic target alteration",36.5,33.9,4.1e-44,438]
["gene0229","Chr1","SMVS","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance.","efflux pump conferring antibiotic resistance","fluoroquinolone antibiotic","antibiotic efflux",33.6,90.6,1.1e-50,492]
["gene0233","Chr1","SMVS","CRP","ARO:3000518","CRP is a global regulator that represses MdtEF multidrug efflux pump expression.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam","antibiotic efflux",94.8,100,1.8e-113,1031]
["gene0238","Chr1","SMVS","salA","ARO:3003749","salA is an ABC transporter gene isolated from the chromosome of Staphylococcus sciuri conferring resistance to lincosamides and streptogramins.","efflux pump conferring antibiotic resistance","lincosamide antibiotic;pleuromutilin antibiotic;streptogramin antibiotic","antibiotic target protection",27.6,81.1,2.7e-56,542]
["gene0240","Chr1","SMVS","rosB","ARO:3003049","rosB is a potassium antiporter in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B","efflux pump conferring antibiotic resistance","peptide antibiotic","antibiotic efflux",27.4,87.5,2.1e-42,422]
["gene0249","Chr1","SMVS","rpsJ","ARO:3003930","rpsJ is a tetracycline resistance protein identified in Neisseria gonorrhoeae. Tetracycline resistance is conferred by binding to the ribosome as a 30S ribosomal protection protein.","antibiotic target protection protein;tetracycline resistance gene","tetracycline antibiotic","antibiotic target protection",72.5,99,5e-37,369]
["gene0319","Chr1","SMVS","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump.","efflux pump conferring antibiotic resistance","-","-",32.4,88.8,6.1e-25,268]
["gene0325","Chr1","SMVS","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump.","efflux pump conferring antibiotic resistance","-","-",25.9,85.1,6.6e-13,164]
["gene0331","Chr1","SMVS","Escherichia coli mutant murA conferring resistance to fosfomycin","ARO:3003775","murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations such as Asp369Asn and Leu370Ile confers fosfomycin resistance. Extensive evidence has shown the significance of C115 mutations in conferring fosfomycin resistance since this residue represents a primary binding site for the antibiotic across many species.","fosfomycin resistance gene;antibiotic resistant gene variant or mutant","-","-",78.9,99.3,7.2e-191,1701]
["gene0363","Chr1","SMVS","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance.","peptide antibiotic resistance gene;antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","peptide antibiotic","antibiotic target alteration",45.8,27.4,2.7E-8,124]
["gene0407","Chr1","SMVS","dfrA3","ARO:3003105","dfrA3 is an integron-encoded dihydrofolate reductase found in Escherichia coli","antibiotic target replacement protein;trimethoprim resistance gene","-","-",53.7,100,7e-46,447]
["gene0410","Chr1","SMVS","Erm(30)","ARO:3001265","Erm(30) confers a MLSb resistant phenotype. Along with erm(31)","antibiotic target modifying enzyme;lincosamide resistance gene;macrolide resistance gene;streptogramin resistance gene","-","-",28.8,92.5,2.7e-18,211]
["gene0423","Chr1","SMVS","vanHD","ARO:3002944","vanHD is a vanH variant in the vanD gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","glycopeptide antibiotic","antibiotic target alteration",33,80.6,9.5e-34,345]
["gene0445","Chr1","SMVS","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion.","efflux pump conferring antibiotic resistance","-","-",29.7,92.8,1.8E-34,351]
["gene0463","Chr1","SMVS","PmrA","ARO:3003582","Response regulator for Lipid A modification genes, two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)","polymyxin resistance gene;gene altering cell wall charge conferring antibiotic resistance","peptide antibiotic","antibiotic target alteration",31.2,99.1,1.3e-29,308]
["gene0464","Chr1","SMVS","arlS","ARO:3000839","ArlS is a protein histidine kinase that phosphorylates ArlR","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","acridine dye;fluoroquinolone antibiotic","antibiotic efflux",22.7,61.3,2.9e-08,126]
["gene0471","Chr1","SMVS","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump.","efflux pump conferring antibiotic resistance","-","-",31.8,67.1,3.3e-24,263]
["gene0479","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",27.6,65,4.1e-16,193]
["gene0480","Chr1","SMVS","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump.","efflux pump conferring antibiotic resistance","-","-",29.3,67.9,2.8e-17,203]
["gene0486","Chr1","SMVS","mtrA","ARO:3000816","MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","macrolide antibiotic;penam","antibiotic efflux",40.3,13.6,5.3e-21,239]
["gene0492","Chr1","SMVS","mexJ","ARO:3003692","mexJ is the membrane fusion protein of the MexJK multidrug efflux protein.","efflux pump conferring antibiotic resistance","macrolide antibiotic;tetracycline antibiotic;triclosan","antibiotic efflux",22.7,80.4,5.4e-09,132]
["gene0493","Chr1","SMVS","mexK","ARO:3003693","mexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein.","efflux pump conferring antibiotic resistance","macrolide antibiotic;tetracycline antibiotic;triclosan","antibiotic efflux",25.3,96.4,1.1e-65,625]
["gene0504","Chr1","SMVS","Escherichia coli sulfonamide resistant mutant folP","ARO:3003386","Point mutations in Escherichia coli dihydropteroate synthase folP prevent sulfonamide antibiotics from inhibiting its role in folate synthesis","antibiotic resistant gene variant or mutant;sulfonamide resistance gene","sulfonamide antibiotic;sulfone antibiotic","antibiotic target alteration",62,99.6,6.2E-98,898]
["gene0511","Chr1","SMVS","otrA","ARO:3002891","otrA is an oxytetracycline resistance ribosomal protection protein found in Streptomyces rimosus","antibiotic target protection protein;tetracycline resistance gene","-","-",36.5,13.2,6.8e-13,169]
["gene0519","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",26.6,64.9,6.9e-46,453]
["gene0566","Chr1","SMVS","carA","ARO:3002817","carA is an ABC transporter involved in macrolide resistance. It is found in Streptomyces thermotolerans","efflux pump conferring antibiotic resistance","-","-",31.4,86.7,3.4e-55,532]
["gene0629","Chr1","SMVS","tet34","ARO:3002870","tet34 causes the activation of Mg2+-dependent purine nucleotide synthesis","gene conferring antibiotic resistance via molecular bypass","-","-",100,100,4.5e-90,828]
["gene0657","Chr1","SMVS","LpxA","ARO:3003573","The LpxA gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane","gene conferring antibiotic resistance via molecular bypass;polymyxin resistance gene;antibiotic resistant gene variant or mutant","-","-",45.3,97.3,9.7e-61,577]
["gene0681","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",36.7,64,3.2e-35,358]
["gene0695","Chr1","SMVS","mecB","ARO:3003440","A foreign PBP2 acquired by lateral gene transfer that able to perform peptidoglycan synthesis in the presence of beta-lactams.","antibiotic resistance gene cluster, cassette, or operon;beta-lactam resistance gene;antibiotic target replacement protein","-","-",26.2,79.6,1.1E-36,373]
["gene0747","Chr1","SMVS","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;aminoglycoside antibiotic","antibiotic efflux",22.8,67.5,1E-13,173]
["gene0748","Chr1","SMVS","Pseudomonas mutant PhoP conferring resistance to colistin","ARO:3003895","Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin.","efflux pump conferring antibiotic resistance;polymyxin resistance gene;gene modulating antibiotic efflux;gene altering cell wall charge conferring antibiotic resistance","-","-",34.8,98.7,2.3e-34,349]
["gene0756","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",33.7,30.8,1.6e-06,110]
["gene0850","Chr1","SMVS","adeR","ARO:3000553","AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","glycylcycline;tetracycline antibiotic","antibiotic efflux",31,28.8,1.5e-13,172]
["gene0939","Chr1","SMVS","patB","ARO:3000025","PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance..","efflux pump conferring antibiotic resistance","fluoroquinolone antibiotic","antibiotic efflux",29.5,97.7,8.1e-51,493]
["gene0980","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",31,80.9,2.6E-24,263]
["gene0991","Chr1","SMVS","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;aminoglycoside antibiotic","antibiotic efflux",26.5,34.4,6.7e-12,159]
["gene1007","Chr1","SMVS","aminocoumarin resistant cysB","ARO:3003840","Positive regulator of gene expression in the cysteine regulon. cysB mutants confer resistance to novobiocin","aminocoumarin resistance gene","-","-",74.5,99.4,4.8e-142,1279]
["gene1011","Chr1","SMVS","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A","efflux pump conferring antibiotic resistance","nitroimidazole antibiotic","antibiotic efflux",31.3,78.8,4.6e-18,209]
["gene1018","Chr1","SMVS","vatB","ARO:3002841","vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus","antibiotic inactivation enzyme;streptogramin resistance gene","streptogramin antibiotic","antibiotic inactivation",46.4,30.4,7.2E-10,137]
["gene1036","Chr1","SMVS","Staphylococcus aureus cls conferring resistance to daptomycin","ARO:3003074","cls or cardiolipin synthetase is an inner membrane protein that is involved in membrane synthesis. Specific mutations in S. aureus can confer resistance to daptomycin.","antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","-","-",25.4,82.1,9e-21,235]
["gene1048","Chr1","SMVS","Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid","ARO:3003463","Specific mutations on the Mycobacterium tuberculosis kasA gene resulting in lowered affinity of isoniazid","antibiotic resistant gene variant or mutant;isoniazid resistance gene","isoniazid;triclosan","antibiotic target alteration",39.8,98.1,3.3e-79,738]
["gene1060","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",30.5,40.6,6.7e-08,122]
["gene1110","Chr1","SMVS","evgA","ARO:3000832","EvgA","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",25.6,24.2,1.6E-7,121]
["gene1111","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",24.9,55.5,1.8E-37,382]
["gene1112","Chr1","SMVS","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase","antibiotic inactivation enzyme;beta-lactam resistance gene;gene modulating beta-lactam resistance","carbapenem;cephalosporin;cephamycin;penam","antibiotic inactivation",28.7,50.5,8.3e-08,121]
["gene1118","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",31.3,76.5,4.5e-23,253]
["gene1119","Chr1","SMVS","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A","efflux pump conferring antibiotic resistance","nitroimidazole antibiotic","antibiotic efflux",33.6,64.8,1.7e-17,205]
["gene1136","Chr1","SMVS","nalD","ARO:3000819","NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;carbapenem;cephalosporin;cephamycin;diaminopyrimidine antibiotic;fluoroquinolone antibiotic;macrolide antibiotic;monobactam;penam;penem;peptide antibiotic;phenicol antibiotic;sulfonamide antibiotic;tetracycline antibiotic","antibiotic efflux",37.3,29.9,8.8e-06,102]
["gene1138","Chr1","SMVS","TriC","ARO:3003681","TriC is a resistance nodulation cell division (RND) transporter that is a part of TriABC-OpmH","efflux pump conferring antibiotic resistance","triclosan","antibiotic efflux",31.4,99.4,5.1e-142,1283]
["gene1162","Chr1","SMVS","Mycobacterium tuberculosis ndh mutant conferring resistance to isoniazid","ARO:3003461","Mutations in the Mycobacterium tuberculosis ndh gene that results in increased resistance to isoniazid.","antibiotic resistant gene variant or mutant;isoniazid resistance gene","isoniazid","antibiotic target alteration",28.7,96.3,3.5E-39,393]
["gene1165","Chr1","SMVS","mfd","ARO:3003844","mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein","antibiotic target protection protein;fluoroquinolone resistance gene","-","-",63.2,98.7,0,3794]
["gene1168","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",38.2,96.5,1.5e-44,437]
["gene1173","Chr1","SMVS","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A","efflux pump conferring antibiotic resistance","nitroimidazole antibiotic","antibiotic efflux",67.2,99.8,2.4e-221,1965]
["gene1187","Chr1","SMVS","efrA","ARO:3003948","efrA is a part of the EfrAB efflux pump","efflux pump conferring antibiotic resistance","fluoroquinolone antibiotic;macrolide antibiotic;rifamycin antibiotic","antibiotic efflux",25,78.1,5.7e-13,165]
["gene1196","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",43.5,91.8,2.5e-44,435]
["gene1230","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",29.3,27.7,1.2e-45,454]
["gene1231","Chr1","SMVS","vanRI","ARO:3003728","VanRI is the regulatory transcriptional activator in the VanSR regulator within the VanI glycopeptide resistance gene cluster.","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",45.8,31.4,1e-18,216]
["gene1232","Chr1","SMVS","mtrA","ARO:3000816","MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","macrolide antibiotic;penam","antibiotic efflux",38.8,23.6,2.2E-16,197]
["gene1239","Chr1","SMVS","tsnr","ARO:3003060","tsnr is a 23S ribosomal RNA methyltransferase that methylates adenosine-1067 to confer resistance to thiostrepton","antibiotic target modifying enzyme;peptide antibiotic resistance gene","-","-",30.9,94.3,8.9e-16,189]
["gene1266","Chr1","SMVS","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A","efflux pump conferring antibiotic resistance","nitroimidazole antibiotic","antibiotic efflux",28,79.1,6.5e-49,478]
["gene1267","Chr1","SMVS","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A","efflux pump conferring antibiotic resistance","nitroimidazole antibiotic","antibiotic efflux",22.1,92.4,3.2e-35,360]
["gene1291","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",33.6,65,1.2E-50,493]
["gene1317","Chr1","SMVS","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance.","peptide antibiotic resistance gene;antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","peptide antibiotic","antibiotic target alteration",34.3,98.1,2.9e-31,322]
["gene1335","Chr1","SMVS","Pseudomonas mutant PhoQ conferring resistance to colistin","ARO:3003896","Mutations in Pseudomonas aeruginosa PhoQ of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin","efflux pump conferring antibiotic resistance;polymyxin resistance gene;gene modulating antibiotic efflux;gene altering cell wall charge conferring antibiotic resistance","macrolide antibiotic;peptide antibiotic","antibiotic efflux;antibiotic target alteration",34.4,61.4,2e-37,378]
["gene1336","Chr1","SMVS","PmrA","ARO:3003582","Response regulator for Lipid A modification genes, two-component system involved in polymyxin resistance that senses high extracellular Fe(2+)","polymyxin resistance gene;gene altering cell wall charge conferring antibiotic resistance","peptide antibiotic","antibiotic target alteration",42.4,99.1,1.5e-46,454]
["gene1347","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",35.7,97,7.6e-29,301]
["gene1352","Chr1","SMVS","OpmH","ARO:3003682","OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function.","efflux pump conferring antibiotic resistance","triclosan","antibiotic efflux",23.8,71.6,2.8e-20,230]
["gene1354","Chr1","SMVS","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance.","efflux pump conferring antibiotic resistance","fluoroquinolone antibiotic","antibiotic efflux",30.1,41.2,1.9E-48,476]
["gene1366","Chr1","SMVS","Salmonella enterica gyrA conferring resistance to fluoroquinolones","ARO:3003926","Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid","antibiotic resistant gene variant or mutant;fluoroquinolone resistance gene","fluoroquinolone antibiotic;nybomycin","antibiotic target alteration",76.1,99.9,0,3414]
["gene1378","Chr1","SMVS","cpxR","ARO:3000831","CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","-","-",41.8,98.6,1.1E-41,412]
["gene1379","Chr1","SMVS","cpxA","ARO:3000830","CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;aminoglycoside antibiotic","antibiotic efflux",30.4,63.1,1.3E-31,328]
["gene1380","Chr1","SMVS","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene.","tetracycline resistance gene;aminoglycoside resistance gene","-","-",22.8,38.5,2.7e-09,137]
["gene1390","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",35.2,93,6.1e-33,337]
["gene1413","Chr1","SMVS","vanRI","ARO:3003728","VanRI is the regulatory transcriptional activator in the VanSR regulator within the VanI glycopeptide resistance gene cluster.","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",29.3,38,1.8E-12,163]
["gene1414","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",34,50.1,5.4e-59,566]
["gene1443","Chr1","SMVS","hmrM","ARO:3003953","hmrM is a multidrug efflux pump belonging to the MATE family and functions as a  Na+/drug antiporter.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic","antibiotic efflux",45.3,100,1.7E-105,965]
["gene1456","Chr1","SMVS","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance","efflux pump conferring antibiotic resistance","-","-",27.8,86.9,2.2E-13,168]
["gene1459","Chr1","SMVS","adeR","ARO:3000553","AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","glycylcycline;tetracycline antibiotic","antibiotic efflux",34.5,23,6.5e-10,141]
["gene1460","Chr1","SMVS","vanSC","ARO:3002933","vanSC is a vanS variant found in the vanC gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",23.7,38.5,1.7E-8,130]
["gene1467","Chr1","SMVS","vgaE","ARO:3002833","vgaE is an efflux protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with transposon DNA.","efflux pump conferring antibiotic resistance","pleuromutilin antibiotic;streptogramin antibiotic","antibiotic target protection",33.5,66.2,3.7e-51,497]
["gene1485","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",31.6,56.7,6.2e-24,261]
["gene1519","Chr1","SMVS","srmB","ARO:3002828","srmB is an efflux pump found in Streptomyces ambofaciens that confers resistance to spiramycin","efflux pump conferring antibiotic resistance","-","-",31.9,79.9,4e-60,575]
["gene1530","Chr1","SMVS","sav1866","ARO:3000489","Sav1866 is a multidrug efflux pump in the Gram-positive Staphylococcus aureus. It is a homolog of the human ABC transporter Mdr1 and pumps out toxic compounds including verapamil","efflux pump conferring antibiotic resistance","-","-",31,96.2,1.4E-62,596]
["gene1543","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",36,88,2.1e-33,341]
["gene1551","Chr1","SMVS","OpmH","ARO:3003682","OpmH is an outer membrane efflux protein required for triclosan-specific efflux pump function.","efflux pump conferring antibiotic resistance","triclosan","antibiotic efflux",21.8,88.5,1.1E-16,199]
["gene1575","Chr1","SMVS","qacA","ARO:3003046","qacA is a subunit of the qac multidrug efflux pump","efflux pump conferring antibiotic resistance","fluoroquinolone antibiotic","antibiotic efflux",27.3,43.5,2E-12,162]
["gene1598","Chr1","SMVS","vanSI","ARO:3003726","VanSI is a vanS variant found in the vanI gene cluster, it is a histidine kinase.","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",31.5,78.1,3.7e-10,139]
["gene1613","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",36,88.3,3.4e-31,322]
["gene1644","Chr1","SMVS","mexN","ARO:3003705","MexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex.","efflux pump conferring antibiotic resistance","phenicol antibiotic","antibiotic efflux",24.3,98,6.4e-63,601]
["gene1808","Chr1","SMVS","Mycobacterium tuberculosis ndh mutant conferring resistance to isoniazid","ARO:3003461","Mutations in the Mycobacterium tuberculosis ndh gene that results in increased resistance to isoniazid.","antibiotic resistant gene variant or mutant;isoniazid resistance gene","isoniazid","antibiotic target alteration",26.9,86.1,1.1E-23,259]
["gene1812","Chr1","SMVS","vatB","ARO:3002841","vatB is a plasmid-mediated acetyltransferase found in Staphylococcus aureus","antibiotic inactivation enzyme;streptogramin resistance gene","streptogramin antibiotic","antibiotic inactivation",45.6,33.3,2.9e-12,158]
["gene1816","Chr1","SMVS","abeM","ARO:3000753","AbeM is an multidrug efflux pump found in Acinetobacter baumannii.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic;triclosan","antibiotic efflux",25.2,96.4,7.3e-32,330]
["gene1848","Chr1","SMVS","Staphylococcus aureus pgsA mutations conferring resistance to daptomycin","ARO:3003323","Point mutations that occur within Staphylococcus aureus pgsA gene resulting in resistance to daptomycin","antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","-","-",30.5,94.1,1.7E-14,177]
["gene1850","Chr1","SMVS","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance.","peptide antibiotic resistance gene;antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","peptide antibiotic","antibiotic target alteration",32.6,97.3,2.8e-25,270]
["gene1859","Chr1","SMVS","vanRF","ARO:3002925","vanRF is a vanR variant found in the vanF gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",31.1,13.9,9.1e-12,159]
["gene1871","Chr1","SMVS","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC","efflux pump conferring antibiotic resistance","-","-",26.1,88.7,4.7e-16,191]
["gene1882","Chr1","SMVS","mexK","ARO:3003693","mexK is the inner membrane resistance-nodulation-cell division (RND) transporter in the MexJK multidrug efflux protein.","efflux pump conferring antibiotic resistance","macrolide antibiotic;tetracycline antibiotic;triclosan","antibiotic efflux",32.1,96.8,2.1e-159,1433]
["gene1883","Chr1","SMVS","mexJ","ARO:3003692","mexJ is the membrane fusion protein of the MexJK multidrug efflux protein.","efflux pump conferring antibiotic resistance","macrolide antibiotic;tetracycline antibiotic;triclosan","antibiotic efflux",27.1,89,6.7e-25,269]
["gene1884","Chr1","SMVS","mexA","ARO:3000377","MexA is the membrane fusion protein of the MexAB-OprM multidrug efflux complex.","efflux pump conferring antibiotic resistance","aminocoumarin antibiotic;carbapenem;cephalosporin;cephamycin;diaminopyrimidine antibiotic;fluoroquinolone antibiotic;macrolide antibiotic;monobactam;penam;penem;peptide antibiotic;phenicol antibiotic;sulfonamide antibiotic;tetracycline antibiotic","antibiotic efflux",26.9,95.9,1e-17,207]
["gene1893","Chr1","SMVS","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance","efflux pump conferring antibiotic resistance","-","-",24.7,71.6,1.7E-14,179]
["gene1894","Chr1","SMVS","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance","efflux pump conferring antibiotic resistance","-","-",28.5,88.1,1.7e-20,230]
["gene1906","Chr1","SMVS","tet35","ARO:3000481","Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes.","efflux pump conferring antibiotic resistance","tetracycline antibiotic","antibiotic efflux",79,68.9,6.4e-160,1435]
["gene1907","Chr1","SMVS","H-NS","ARO:3000676","H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","cephalosporin;cephamycin;fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",55.1,100,7.8e-30,308]
["gene1929","Chr1","SMVS","patA","ARO:3000024","PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance.","efflux pump conferring antibiotic resistance","fluoroquinolone antibiotic","antibiotic efflux",33.3,88.8,1.4e-45,448]
["gene1940","Chr1","SMVS","lmrD","ARO:3002882","lmrD is a chromosomally-encoded efflux pump that confers resistance to lincosamides in Streptomyces lincolnensis and Lactococcus lactis. It can dimerize with lmrC","efflux pump conferring antibiotic resistance","-","-",25.8,54.3,2e-23,258]
["gene1949","Chr1","SMVS","Pseudomonas mutant PhoP conferring resistance to colistin","ARO:3003895","Mutations in Pseudomonas aeruginosa PhoP of the two-component PhoPQ regulatory system. Presence of mutation confers resistance to colistin.","efflux pump conferring antibiotic resistance;polymyxin resistance gene;gene modulating antibiotic efflux;gene altering cell wall charge conferring antibiotic resistance","-","-",36.6,89.3,2.6e-30,314]
["gene1954","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",28.1,62.6,7.7e-53,513]
["gene1976","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",32.3,48,1.5E-51,502]
["gene2026","Chr1","SMVS","mtrA","ARO:3000816","MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","macrolide antibiotic;penam","antibiotic efflux",35.5,97.9,5.5e-39,389]
["gene2094","Chr1","SMVS","vgaB","ARO:3000118","Vga(B) is an efflux protein expressed in staphylococci that confers resistance to streptogramin A antibiotics and related compounds. It is associated with plasmid DNA.","efflux pump conferring antibiotic resistance","pleuromutilin antibiotic;streptogramin antibiotic","antibiotic target protection",28.3,95.1,5.4e-14,173]
["gene2099","Chr1","SMVS","mtrA","ARO:3000816","MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","macrolide antibiotic;penam","antibiotic efflux",29.8,34.3,1.6e-08,128]
["gene2102","Chr1","SMVS","mtrA","ARO:3000816","MtrA is a transcriptional activator of the MtrCDE multidrug efflux pump of Neisseria gonorrhoeae.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","macrolide antibiotic;penam","antibiotic efflux",33.1,96,6.2e-13,162]
["gene2119","Chr1","SMVS","bcrA","ARO:3002987","bcrA is an ABC transporter found in Bacillus licheniformis that confers bacitracin resistance","efflux pump conferring antibiotic resistance","-","-",27.9,91.2,1.7e-20,230]
["gene2129","Chr1","SMVS","vanHO","ARO:3002948","vanHO is a vanH variant in the vanO gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","-","-",26.3,60.6,1.1E-20,233]
["gene2196","Chr1","SMVS","NmcR","ARO:3003665","NmcR is a homolog of the LysR regulator found in Enterobacter cloacae that contribute to the regulation of NmcA beta-lactamase","antibiotic inactivation enzyme;beta-lactam resistance gene;gene modulating beta-lactam resistance","carbapenem;cephalosporin;cephamycin;penam","antibiotic inactivation",32.4,94.9,3.2e-36,366]
["gene2231","Chr1","SMVS","rosB","ARO:3003049","rosB is a potassium antiporter in Yersinia that confers resistance to cationic antimicrobial peptides such as polymyxin B","efflux pump conferring antibiotic resistance","peptide antibiotic","antibiotic efflux",29,46.4,4.3e-07,117]
["gene2309","Chr1","SMVS","tet35","ARO:3000481","Tet35 is a tetracycline efflux pump found in the Gram-negative Vibrio and Stenotrophomonas. It is unrelated to other tet resistance genes.","efflux pump conferring antibiotic resistance","tetracycline antibiotic","antibiotic efflux",31.6,62.1,9.1e-39,390]
["gene2322","Chr1","SMVS","clbB","ARO:3002815","clbB is a plasmid-encoded cfr gene found in Bacillus brevis","linezolid resistance gene;lincosamide resistance gene;macrolide resistance gene;antibiotic target modifying enzyme;phenicol resistance gene;streptogramin resistance gene","-","-",34.8,86.9,3.9e-47,461]
["gene2336","Chr1","SMVS","mexW","ARO:3003031","MexW is the RND-type membrane protein of the efflux complex MexVW-OprM.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic;macrolide antibiotic;phenicol antibiotic;tetracycline antibiotic","antibiotic efflux",35.7,97.6,2.1e-167,1502]
["gene2337","Chr1","SMVS","mexV","ARO:3003030","MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic;macrolide antibiotic;phenicol antibiotic;tetracycline antibiotic","antibiotic efflux",29.2,89.1,2.2e-31,325]
["gene2343","Chr1","SMVS","leuO","ARO:3003843","leuO","sulfonamide resistance gene;gene modulating antibiotic efflux","-","-",27.3,58.9,3.3E-15,185]
["gene2346","Chr1","SMVS","novA","ARO:3002522","A type III ABC transporter","efflux pump conferring antibiotic resistance","-","-",30.3,81.6,2.9e-23,254]
["gene2351","Chr1","SMVS","baeS","ARO:3000829","BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;aminoglycoside antibiotic","antibiotic efflux",30.8,53.4,2.8e-28,299]
["gene2352","Chr1","SMVS","arlR","ARO:3000838","ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","acridine dye;fluoroquinolone antibiotic","antibiotic efflux",38.6,96.1,6.1e-43,423]
["gene2398","Chr1","SMVS","tetT","ARO:3000193","Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q).","antibiotic target protection protein;tetracycline resistance gene","tetracycline antibiotic","antibiotic target protection",28.1,95.5,5.7e-68,643]
["gene2426","Chr1","SMVS","LpxC","ARO:3003574","The LpxC gene is widely known to be involved in the biosynthesis of lipid A in Gram-negative bacteria and mutations to this gene may cause resistance to antimicrobial peptides that target the outer membrane","gene conferring antibiotic resistance via molecular bypass;polymyxin resistance gene;antibiotic resistant gene variant or mutant","-","-",50.9,97.3,2.1E-88,816]
["gene2437","Chr1","SMVS","Neisseria meningititis PBP2 conferring resistance to beta-lactam","ARO:3003937","Point mutation in Neisseria meningititis PBP2 (penA) decreases affinity between beta-lactam antibiotic molecule and PBP2","antibiotic resistant gene variant or mutant;beta-lactam resistance gene","carbapenem;cephalosporin;cephamycin;monobactam;penam","antibiotic target alteration",38.6,98.4,4.7e-108,988]
["gene2458","Chr1","SMVS","Salmonella enterica parC conferring resistance to fluoroquinolones","ARO:3003939","Point mutations in Salmonella parC gene implicated in decreased susceptibility to fluoroquinolone antibiotics","antibiotic resistant gene variant or mutant;fluoroquinolone resistance gene","fluoroquinolone antibiotic","antibiotic target alteration",69.5,97.2,0,2756]
["gene2459","Chr1","SMVS","Salmonella serovars parE conferring resistance to fluoroquinolones","ARO:3003317","Point mutation in Salmonella serovars parE resulting in fluoroquinolones resistance","antibiotic resistant gene variant or mutant;fluoroquinolone resistance gene","fluoroquinolone antibiotic","antibiotic target alteration",79,100,2.5e-304,2681]
["gene2464","Chr1","SMVS","tolC","ARO:3000237","TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex.","efflux pump conferring antibiotic resistance","aminocoumarin antibiotic;cephalosporin;cephamycin;fluoroquinolone antibiotic;glycylcycline;macrolide antibiotic;penam;phenicol antibiotic;rifamycin antibiotic;tetracycline antibiotic;triclosan","antibiotic efflux",46.2,99.1,1e-102,941]
["gene2495","Chr1","SMVS","tetS","ARO:3000192","Tet(S) is a ribosomal protection protein found in Gram-positive and Gram-negative strains. It is similar to tet(M) and tet(O).","antibiotic target protection protein;tetracycline resistance gene","tetracycline antibiotic","antibiotic target protection",24.9,83.7,8e-38,382]
["gene2503","Chr1","SMVS","CdeA","ARO:3003835","Clostridium difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in C.difficile.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic","antibiotic efflux",27.6,92.2,5.2e-46,452]
["gene2519","Chr1","SMVS","vanRA","ARO:3002919","vanRA","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","glycopeptide antibiotic","antibiotic target alteration",35.1,95.4,1.9e-34,350]
["gene2537","Chr1","SMVS","evgS","ARO:3000833","EvgS is a sensor protein that phosphorylates the regulatory protein EvgA.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","fluoroquinolone antibiotic;macrolide antibiotic;penam;tetracycline antibiotic","antibiotic efflux",32.6,27.2,8.3e-30,315]
["gene2544","Chr1","SMVS","tetB(P)","ARO:3000195","TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P)","antibiotic target protection protein;tetracycline resistance gene","tetracycline antibiotic","antibiotic target protection",37.5,25,9.7e-24,261]
["gene2562","Chr1","SMVS","vanHB","ARO:3002943","vanHB is a vanH variant in the vanB gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","glycopeptide antibiotic","antibiotic target alteration",31.7,52.6,5.1e-24,262]
["gene2566","Chr1","SMVS","leuO","ARO:3003843","leuO","sulfonamide resistance gene;gene modulating antibiotic efflux","-","-",52.5,91,2.3e-80,747]
["gene2613","Chr1","SMVS","aminocoumarin resistant alaS","ARO:3003830","alanyl-tRNA synthetase conferring resistance to novobiocin in Escherichia coli","aminocoumarin resistance gene","-","-",67.1,100,0,3028]
["gene2664","Chr1","SMVS","emrE","ARO:3000264","EmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa.","efflux pump conferring antibiotic resistance","-","-",42.7,99.1,3e-19,216]
["gene2687","Chr1","SMVS","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion.","efflux pump conferring antibiotic resistance","-","-",29.3,90.2,6.8e-19,216]
["gene2692","Chr1","SMVS","drrA","ARO:3003944","Doxorubicin resistance ATP-binding protein DrrA (DrrA) is part of the drrAB efflux pump.","efflux pump conferring antibiotic resistance","-","-",28.7,72.3,2.2e-15,186]
["gene2721","Chr1","SMVS","oleC","ARO:3003748","oleC is an ABC transporter isolated from Streptomyces antibioticus and is involved in oleandomycin secretion.","efflux pump conferring antibiotic resistance","-","-",31.8,92.7,2.4e-18,211]
["gene2736","Chr1","SMVS","msbA","ARO:3003950","MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A","efflux pump conferring antibiotic resistance","nitroimidazole antibiotic","antibiotic efflux",28.9,88.1,6.6e-16,190]
["gene2743","Chr1","SMVS","vanTG","ARO:3002972","vanTG is a vanT variant found in the vanG gene cluster","glycopeptide resistance gene;gene conferring antibiotic resistance via molecular bypass;antibiotic resistance gene cluster, cassette, or operon","glycopeptide antibiotic","antibiotic target alteration",30.8,98.3,2.7e-45,445]
["gene2752","Chr1","SMVS","Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa","ARO:3003370","Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa","antibiotic resistant gene variant or mutant;elfamycin resistance gene","-","-",85.5,99.5,3.2e-201,1790]
["gene2753","Chr1","SMVS","tetT","ARO:3000193","Tet(T) is a ribosomal protection protein of streptococci. It is similar to Tet(Q).","antibiotic target protection protein;tetracycline resistance gene","tetracycline antibiotic","antibiotic target protection",27.9,96,3.3e-71,671]
["gene2755","Chr1","SMVS","Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin","ARO:3003395","Ribosomal protein S12 stabilizes the highly conserved","antibiotic resistant gene variant or mutant;aminoglycoside resistance gene","aminoglycoside antibiotic","antibiotic target alteration",69.9,99.2,2.1E-45,442]
["gene2797","Chr1","SMVS","Staphylococcus aureus rpoC conferring resistance to daptomycin","ARO:3003291","Point mutations that occurs in Staphylococcus aureus rpoC resulting in resistance to daptomycin","antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","-","-",54.1,66.2,2.5e-296,2615]
["gene2798","Chr1","SMVS","Escherichia coli rpoB mutants conferring resistance to rifampicin","ARO:3003288","Point mutations that occurs in Escherichia coli rpoB resulting in resistance to rifampicin","rifampin resistance gene;antibiotic resistant gene variant or mutant","peptide antibiotic;rifamycin antibiotic","antibiotic target alteration;antibiotic target replacement",84.8,99.9,0,5924]
["gene2806","Chr1","SMVS","Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa","ARO:3003370","Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Enacyloxin IIa","antibiotic resistant gene variant or mutant;elfamycin resistance gene","-","-",85.5,99.5,3.2e-201,1790]
["gene2827","Chr1","SMVS","cpxR","ARO:3000831","CpxR is a regulator that promotes acrD expression when phosphorylated by a cascade involving CpxA","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","-","-",61.1,98.7,6.7e-74,690]
["gene2828","Chr1","SMVS","cpxA","ARO:3000830","CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","aminocoumarin antibiotic;aminoglycoside antibiotic","antibiotic efflux",44.9,98.3,2.5E-96,886]
["gene2835","Chr1","SMVS","Enterococcus faecium liaR mutant conferring daptomycin resistance","ARO:3003078","liaR is a response regulator found in the liaFSR signal transduction pathway. Mutations confer daptomycin resistance.","peptide antibiotic resistance gene;antibiotic resistant gene variant or mutant;lipopeptide antibiotic resistance gene","peptide antibiotic","antibiotic target alteration",25.9,92.9,1.4E-14,178]
["gene2855","Chr1","SMVS","golS","ARO:3000504","GolS is a regulator activated by the presence of gold","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","carbapenem;cephalosporin;cephamycin;monobactam;penam;penem;phenicol antibiotic","antibiotic efflux",35.6,90.4,1.8e-16,193]
["gene2886","Chr1","SMVS","fyuA","ARO:3003833","fyuA is a pesticin receptor that is found in E.coli. The fyuA gene encodes the outer membrane receptor for the siderophore yersiniabactin (Ybt) and the hemR gene.","tetracycline resistance gene;aminoglycoside resistance gene","-","-",30.1,25.8,2.8e-08,128]
["gene2904","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",32,87.5,3.8e-29,304]
["gene2981","Chr1","SMVS","PmrC","ARO:3003576","PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine","polymyxin resistance gene;gene altering cell wall charge conferring antibiotic resistance","peptide antibiotic","antibiotic target alteration",35.5,97.7,8.3e-110,1003]
["gene2986","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",31.2,40.2,3.6e-23,256]
["gene2994","Chr1","SMVS","Klebsiella pneumoniae ramR mutants","ARO:3003380","RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB","efflux pump conferring antibiotic resistance;antibiotic resistant gene variant or mutant;gene modulating antibiotic efflux","cephalosporin;fluoroquinolone antibiotic;glycylcycline;penam;phenicol antibiotic;rifamycin antibiotic;tetracycline antibiotic;triclosan","antibiotic efflux;antibiotic target alteration",38.5,48.7,9.8e-10,136]
["gene2995","Chr1","SMVS","mexV","ARO:3003030","MexV is the membrane fusion protein of the MexVW-OprM multidrug efflux complex.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic;macrolide antibiotic;phenicol antibiotic;tetracycline antibiotic","antibiotic efflux",37.4,97.5,7.1e-62,588]
["gene2996","Chr1","SMVS","mexW","ARO:3003031","MexW is the RND-type membrane protein of the efflux complex MexVW-OprM.","efflux pump conferring antibiotic resistance","acridine dye;fluoroquinolone antibiotic;macrolide antibiotic;phenicol antibiotic;tetracycline antibiotic","antibiotic efflux",48.8,97,1.7E-270,2391]
["gene3033","Chr1","SMVS","mexT","ARO:3000814","MexT is a LysR-type transcriptional activator that positively regulates the expression of MexEF-OprN and OprD.","efflux pump conferring antibiotic resistance;gene modulating antibiotic efflux","diaminopyrimidine antibiotic;fluoroquinolone antibiotic;phenicol antibiotic","antibiotic efflux",30.2,97.4,6.4e-35,355]
["gene3075","Chr1","SMVS","Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin","ARO:3003470","Specific mutations that occurs on Mycobacterium tuberculosis gidB causing it to be streptomycin resistant","antibiotic target modifying enzyme;antibiotic resistant gene variant or mutant;aminoglycoside resistance gene","aminoglycoside antibiotic","antibiotic target alteration",31.8,71.4,1.1E-17,205]
["gene3082","Chr1","SMVS","macB","ARO:3000535","MacB is an ATP-binding cassette (ABC) transporter that exports macrolides with 14- or 15- membered lactones. It forms an antibiotic efflux complex with MacA and TolC.","efflux pump conferring antibiotic resistance","macrolide antibiotic","antibiotic efflux",39.1,95.1,2e-36,367]
["gene3095","Chr2","SMVS","sul2","ARO:3000412","Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria","antibiotic target replacement protein;sulfonamide resistance gene","sulfonamide antibiotic;sulfone antibiotic","antibiotic target replacement",100,100,6.4e-148,1329]
["gene3096","Chr2","SMVS","APH(3'')-Ib","ARO:3002639","APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids","antibiotic inactivation enzyme;aminoglycoside resistance gene","aminoglycoside antibiotic","antibiotic inactivation",99.6,100,6e-159,1424]
["gene3097","Chr2","SMVS","APH(6)-Id","ARO:3002660","APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids","antibiotic inactivation enzyme;aminoglycoside resistance gene","aminoglycoside antibiotic","antibiotic inactivation",99.6,100,1.1e-160,1439]
["gene3116","Chr2","SMVS","tetR","ARO:3003479","TetR is the repressor of the tetracycline resistance element, its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin","efflux pump conferring antibiotic resistance;antibiotic resistant gene variant or mutant;gene modulating antibiotic efflux","glycylcycline;tetracycline antibiotic","antibiotic efflux;antibiotic target alteration",64.3,99,8e-74,689]
["gene3117","Chr2","SMVS","tet31","ARO:3000476","Tet31 is a tetracycline efflux pump found in Aeromonas salmonicida","efflux pump conferring antibiotic resistance","tetracycline antibiotic","antibiotic efflux",99.5,100,3.8e-221,1962]
["gene3119","Chr2","SMVS","sul2","ARO:3000412","Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria","antibiotic target replacement protein;sulfonamide resistance gene","sulfonamide antibiotic;sulfone antibiotic","antibiotic target replacement",100,100,6.4e-148,1329]