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["CellMiner address:","http://discover.nci.nih.gov/cellminer/",{"$nulls":3},"William C. Reinhold"]
[{"$nulls":5},"NIH"]
[{"$nulls":5},"Developmental Therapeutics Branch"]
[{"$nulls":5},"Phone","301-496-9572"]
[{"$nulls":5},"FAX","301-402-0752"]
[{"$nulls":5},"email","wcr@mail.nih.gov"]
["Table 1: Metadata on the NCI-60 panel of cancer cell lines"]
["Cell Line Name","tissue of origin a","age a","sex a","prior treatment a,b","Epithelial","histology a,c","source","ploidy d","p53 e","mdr f","doubling time g","Institute ","Contributor","Reference"]
["BR:MCF7","Breast",69,"F","NA","yes","Adenocarcinoma- mammary gland; breast; metastatic site: pleural effusion;","Pleural effusion","3n-, Hypotriploid (58-68)","WT",14,25.4,"Michigan Cancer Foundtion","C.M. McGrath","JNCI 51: 1409-1417,1973"]
["BR:MDA_MB_231","Breast",51,"F","NA","yes","Adenocarcinoma-mammary gland; breast; epithelial; metastatic site: pleural effusion;","Pleural effusion","2n+, Hyperdiploid (47-57)","MT",29,41.9,"MD Anderson Hospital and Tumor Institute","R. Cailleau","JNCI 53(3): 661-674,1974"]
["BR:HS578T","Breast",74,"F","NA","yes","Carcinosarcoma-mammary gland; breast","Primary","2n+, Hyperdiploid (47-57)","MT","NA",53.8,"Naval Bioscience Laboratory","A.J. Hackett","JNCI 58: 1795-1806,1977"]
["BR:BT_549","Breast",72,"F","NA","yes","Papillary infiltrating ductal carcinoma-mammary gland; breast","Metastasis","3n+/-, Near-triploid 69+/- (58-80)","?",-45,53.9,"?","W. Coutinho; E.Y. Lasfargues","no pub"]
["BR:T47D","Breast",54,"F","NA","yes","infiltrating ductal carcinoma","NA","2n+, Hyperdiploid (47-57)","MT",19,45.5,"?","I. Keydar","Eur J Cancer 15:659-679,1979"]
["CNS:SF_268","Central nervous system",24,"F","Rad","no","Glioblastoma, ud","NA","2n+, Hyperdiploid (47-57)","MT",-38,33.1,"?","P.L.Kornblith","Acta Neuropathol 75: 92-103, 1987"]
["CNS:SF_295","Central nervous system",67,"F","Rad","no","Glioblastoma, ud","NA","5n+/-, Near-pentaploid 115+/- (104-126)","MT",91,29.5,"University of California","M.L. Rosenblum","Acta Neuropathol 75: 92-103, 1988"]
["CNS:SF_539","Central nervous system",34,"F","Rad/BCNU/5FU/HU/6MP","no","Glial cell neoplasm","NA","4n+/-, Near-tetraploid 92+/- (81-103)","WT",-40,35.4,"University of California","M.L. Rosenblum","J Neuropathol Exp Neurol 40: 201-229, 1981"]
["CNS:SNB_19","Central nervous system",47,"M","None","no","Glioblastoma, ud","NA","3n+/-, Near-triploid 69+/- (58-80)","MT",-41,34.6,"NINCDS","P.L. Kornblith","Cancer 47: 255, 1981"]
["CNS:SNB_75","Central nervous system","NA","F","None","no","Astrocytoma","NA","2n+, Hyperdiploid (47-57)","MT",-38,62.8,"NINCDS","P.L. Kornblith","?"]
["CNS:U251","Central nervous system",75,"M","NA","no","Glioblastoma,ud","NA","2n+, Hyperdiploid (47-57)","MT",-19,23.8,"University of Uppsala, Sweden","?","J Neuropathol Exp Neurol 40: 410-427, 1981"]
["CO:COLO205","Colon",70,"M","NA","yes","Adenocarcinoma","Ascites","3n, Triploid (69)","MT",7,23.8,"Denver Medical Hospital","G.E. Moore","Can Res. 38: 1345-1355, 1978"]
["CO:HCC_2998","Colon","NA","NA","NA","yes","carcinoma","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",-5,31.5,"MD Anderson Hospital and Tumor Institute","?","?"]
["CO:HCT_116","Colon","NA","M","NA","yes","carcinoma-vpd","NA","2n-, Hypodiploid (35-45)","?",26,17.4,"Baylor College","?","Can Res 41: 1761-1756, 1981"]
["CO:HCT_15","Colon","NA","NA","None","yes","Adenocarcinoma p/md","NA","2n+/-, Near-diploid 46+/- (35-57)","?",414,20.6,"ATCC","ATCC (D.L. Dexter, Roger Williams General Hospital)","Can Res 39: 1020-1025, 1979"]
["CO:HT29","Colon",44,"F","None","yes","Adenocarcinoma-md","Primary","3n+/-, Near-triploid 69+/- (58-80)","MT",15,19.5,"Memorial Sloan Kettering Cancer Center","J. Fogh","Human Tumor Cells in vitro: 115-159, 1975"]
["CO:KM12","Colon","NA","NA","None","yes","Adenocarcinome-pd","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",-19,23.7,"MD Anderson Hospital and Tumor Institute","I.J. Fidler, Univ of Texas M.D. Anderson Hospital and Tumor Institute","Can Res 48: 1943-1948, 1988"]
["CO:SW_620","Colon",51,"M","NA","yes","Carcinoma-ud","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",31,20.4,"Scott White Clinic","A. Leibovitz","Can Res 1976 Dec;36(12):4562-9"]
["LE:CCRF_CEM","Leukemia",4,"F","Rad/Mtx/Ctx","no","ALL","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",35,26.7,"Children's Cancer research Foudation","G.E. Foley","Cancer 18: 522-529, 1965"]
["LE:HL_60","Leukemia",36,"F","None","no","Pro myelocytic leukemia","PBL","2n+/-, Near-diploid 46+/- (35-57)","MT",-11,28.6,"NCI","R.C. Gallo","Blood 54(3):713-33, 1979"]
["LE:K_562","Leukemia",53,"F","Bisulfan/PiBr","no","CML","Pleural effusion","3n-, Hypotriploid (58-68)","MT",-1,19.6,"University of Tennesse","H.T. Holden","Blood 45: 321-334, 1975"]
["LE:MOLT_4","Leukemia",19,"M","VB/6MP/Pred","no","ALL (cells were taken when patient was in relapse)","PB","4n, Tetraploid (92)","WT",10,27.9,"Roswell Park Memorial Institute","J. Minowada","J. Natl. Cancer Inst. 49: 891-895, 1972"]
["LE:RPMI_8226","Leukemia",61,"M","None","no","Myeloma","PB","3n-, Hypotriploid (58-68)","WT",-3,33.5,"?","G.E. Moore","Proc Soc Exp Biol Med 125: 1246-1250, 1967"]
["LE:SR","Leukemia",11,"M","None","no","Lymphoma","NA","2n+/-, Near-diploid 46+/- (35-57)","?",4,28.7,"Program Resources, Inc.","W.J. Urba, Program Resources, Inc.","?"]
["ME:LOXIMVI h","Melanoma",58,"M","None","no","Malignant amelanotic melanoma","NA","3n+/-, Near-triploid 69+/- (58-80)","WT",12,20.5,"Norsk Hydro's Institut, Norway","?","Int J Cancer 41: 442-449, 1988"]
["ME:MALME_3M","Melanoma",43,"M","None","no","Malignant melanotic melanoma","Metastasis","4n+/-, Near-tetraploid 92+/- (81-103)","WT",22,46.2,"Memorial Sloan Kettering Cancer Center","J. Fogh","J. Natl. Cancer Inst. 59: 221-226, 1977"]
["ME:M14","Melanoma","NA","NA","NA","no","Melanotic melanoma","NA","3n+/-, Near-triploid 69+/- (58-80)","MT",14,26.3,"John Wayne Cancer Clinic, UCLA School of Medicine","D.H. Kern, John Wayne Cancer Clinic, UCLA School of Medicine","Cancer Res 48: 578-582, 1988"]
["ME:SK_MEL_2","Melanoma",60,"M","None","no","Malignant melanotic melanoma","Metastasis","4n-, Hypotetraploid (81-91)","WT",14,45.5,"Memorial Sloan Kettering Cancer Center","G. Trempe; L.J. Old","Human Tumor Cells in vitro, pp 115-159, 1975"]
["ME:SK_MEL_28","Melanoma",51,"M","None","no","Malignant melanotic melanoma","NA","4n-, Hypotetraploid (81-91)","MT",11,35.1,"Memorial Sloan Kettering Cancer Center","T. Takahashi","PNAS 73: 3278-3282, 1976"]
["ME:SK_MEL_5","Melanoma",24,"F","None","no","Malignant melanotic melanoma","Metastasis","4n+, Hypertetraploid (93-103)","WT",12,25.2,"Memorial Sloan Kettering Cancer Center","T. Takahashi","PNAS, 73: 3278-3282, 1976"]
["ME:UACC_257","Melanoma","NA","NA","NA","no","Melanotic melanoma","NA","3n+, Hypertriploid (70-80)","WT",26,38.5,"University of Arizona","A. Leibovitz, UACC","?"]
["ME:UACC_62","Melanoma","NA","NA","NA","no","Melanotic melanoma","NA","3n+/-, Near-triploid 69+/- (58-80)","WT",8,31.3,"University of Arizona","A. Leibovitz, UACC","?"]
["ME:MDA_MB_435 i","Melanoma",31,"F","NA","no","Ductal carcinoma- mammary gland; breast; duct; metastatic site: pleural effusion;","Pleural effusion","2n+, Hyperdiploid (47-57)","MT",20,25.8,"?","R. Cailleau","Cancer Res 40:3118-3129,1980"]
["ME:MDA_N j","Melanoma",31,"F","NA","no","Ductal carcinoma- mammary gland; breast; duct; metastatic site: pleural effusion;","Pleural effusion","NA","MT",12,22.5,"?","?","?"]
["LC:A549","Non-Small Cell Lung",58,"M","NA","yes","Adenocarcinoma-p/md","NA","3n+/-, Near-triploid 69+/- (58-80)","WT",10,22.9,"NCI","Giard DJ","J Natl Cancer Inst. 51(5):1417-23, 1973"]
["LC:EKVX","Non-Small Cell Lung","NA","M","NA","yes","Adenocarcinoma-md","NA","3n+/-, Near-triploid 69+/- (58-80)","MT",-9,43.6,"Norsk Hydro's Institut, Norway","?","?"]
["LC:HOP_62","Non-Small Cell Lung",60,"F","None","yes","adenocarcinoma-ud","NA","4n+, Hypertetraploid (93-103)","MT",61,39,"Johns Hopkins University","M.Liu","?"]
["LC:HOP_92","Non-Small Cell Lung",62,"M","None","yes","Large cell-ud","NA","4n+/-, Near-tetraploid 92+/- (81-103)","MT",-4,79.5,"Johns Hopkins University","M.Liu","?"]
["LC:NCI_H226","Non-Small Cell Lung","NA","M","None (non smoker)","yes","Squamous cell carcinoma-vpd","NA","3n, Triploid (69)","MT",7,61,"NCI","J.D. Minna; A.F. Gazdar","Cancer Res. 40: 3502-3507, 1980"]
["LC:NCI_H23","Non-Small Cell Lung","NA","M","None","yes","Adenocarcinoma-ud","NA","2n+, Hyperdiploid (47-57)","MT",-2,33.4,"NCI","J.D. Minna; A.F. Gazdar","Cancer Res. 40: 3502-3507, 1980"]
["LC:NCI_H322M","Non-Small Cell Lung",52,"M","None","yes","Small cell Bronchioalveolar Carcinoma","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",-10,35.3,"NCI","?","?"]
["LC:NCI_H460","Non-Small Cell Lung","NA","M","NA","yes","Large Cell Carcinoma-ud","Pleural effusion","2n+/-, Near-diploid 46+/- (35-57)","WT",25,17.8,"NCI","J.D. Minna; A.F. Gazdar","Science 246: 491-494, 1989"]
["LC:NCI_H522","Non-Small Cell Lung","NA","M","None","yes","Adenocarcinoma-vpd","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",16,38.2,"NCI","?","Can Res 45: 2913-2923, 1985"]
["OV:IGROV1","Ovarian",47,"F","Rad","yes","Cystoadenocarcinoma-pd","NA","4n+/-, Near-tetraploid 92+/- (81-103)","MT",20,31,"Institute Gustave Roussy, France","?","Can Res 45: 4970-4979,1985"]
["OV:OVCAR_3","Ovarian",60,"F","CyPh/CsPt/Adr","yes","Adenocarcinoma-md","Ascites","3n+/-, Near-triploid 69+/- (58-80)","MT",-12,34.7,"NCI","T.C. Hamilton","Sem Ocol 11: 285-298, 1984"]
["OV:OVCAR_4","Ovarian",42,"F","CyPh/CsPt/Adr","yes","Adenocarcinoma-md","NA","3n+/-, Near-triploid 69+/- (58-80)","WT",-4,41.4,"NCI","T.C. Hamilton","Sem Ocol 11: 285-298, 1984"]
["OV:OVCAR_5","Ovarian",67,"F","None","yes","Adenocarcinoma-wd","NA","2n+, Hyperdiploid (47-57)","MT",13,48.8,"NCI","R. Ozols","Sem Ocol 11: 285-298, 1985"]
["OV:OVCAR_8","Ovarian",64,"F","Ctx/Adr/CsPt/CyPh","yes","Carcinoma-ud","NA","2n+, Hyperdiploid (47-57)","MT",7,26.1,"NCI","T.C. Hamilton","?"]
["OV:SK_OV_3","Ovarian",64,"F","Thiotepa","yes","Adenocarcinoma-vpd","Ascites","4n+/-, Near-tetraploid 92+/- (81-103)","?",15,48.7,"Memorial Sloan Kettering Cancer Center","?","Human Tumor Cells in vitro, pp. 115-159, 1975"]
["OV:NCI_ADR_RES k","Ovarian","NA","F","NA","yes","Adenocarinoma","NA","2n+/-, Near-diploid 46+/- (35-57)","MT",352,34,"NCI","K.Cowan, NCI","Cancer Res., 46:4087-4090,1986"]
["PR:PC_3","Prostate",62,"M","NA","yes","Adenocarcinoma- prostate; metastatic site: bone;","NA","4n, Tetraploid (92)","MT",11,27.1,"Pasadena Center for Medical Research","M.E. Kaighn","Invest Urol 1979 Jul;17(1):16-23"]
["PR:DU_145","Prostate",69,"M","Androgen independent and unresposive to hormone therapy","yes","prostate; metastatic site: brain; carcinoma (patient with metastatic carcinoma of the prostate and a 3 year history of lymphocytic leukemia.)","Metastasis","3n+/-, Near-triploid 69+/- (58-80)","?",4,32.3,"Washington University School of Medicine, Saint Louis, MO","K.R. Stone","Int J Cancer 21: 274-281,1978"]
["RE:786_0","Renal",58,"M","None","yes","Adenocarcinoma","NA","4n+/-, Near-tetraploid 92+/- (81-103)","MT",-44,22.4,"?","R.D.Williams, Univ. of Iowa","In Vitro 14: 779-786, 1978"]
["RE:A498","Renal",52,"F","NA","yes","Adenocarcinoma","NA","3n, Triploid (69)","WT",78,66.8,"NCI","?","JNCI 51: 1417-1423,1973"]
["RE:ACHN","Renal",22,"M","Rad/VB/CCNU/Mto/Pred","yes","Renal cell carcinoma-p/md","NA","2n+/-, Near-diploid 46+/- (35-57)","WT",120,27.5,"Southern Research Inst. (T.F. Hogan, Middleton memorial VA hospital)","S.M.Schmid","Cancer Res 42: 4948-4953, 1982"]
["RE:CAKI_1","Renal",49,"M","Rad/HU/5FU/Mtx/Ctx","yes","Clear cell carcinoma","Metastasis","3n, Triploid (69)","WT",171,39,"Memorial Sloan Kettering Cancer Center","J. Fogh","Human Tumor cells in vitro, pp 115-159, 1975"]
["RE:RXF_393","Renal",54,"M","None","yes","hypernephroma-pd","NA","3n+/-, Near-triploid 69+/- (58-80)","MT",42,62.9,"MD Anderson Hospital and Tumor Institute","NCI/DCT/DTP","Contrib oncol 42, 1992 "]
["RE:SN12C","Renal",43,"M","None","yes","Renal cell carcinoma-pd","NA","3n, Triploid (69)","MT",-86,29.5,"MD Anderson Hospital and Tumor Institute",".J.Fidler","Cancer Res 46: 4109-4115, 1986"]
["RE:TK_10","Renal",43,"M","None","yes","Renal Spindle cell carcinoma","NA","4n, Tetraploid (92)","MT",-4,51.3,"?","R.V.Clayman, Washington Univ.School of Medicine","Cancer Res 46: 3856-3862, 1987"]
["RE:UO_31","Renal","NA","F","None","yes","Renal cell carcinoma-vpd","NA","2n+/-, Near-diploid 46+/- (35-57)","WT",59,41.7,"NCI","W.M.Linehan","?"]
[]
[]
["Footnotes"]
["a Information from Stinson, et al., (Anticancer Res. 1992 Jul-Aug;12(4):1035-53), DTP, ATCC, and other sources."]
["b Prior_Treatment: BCNU=Bis(chlorethyl)nitrosourea;CCNU=chloroethylecyclohexylnitrosourea; CyPh=cyclophosphamide;CsPt=cisplatin;Ctx=cytoxan;5FU=5-fluorouracil; "]
["Hu=hydroxyurea;Mto=mitoxantrone;Pred=prednisone;VB=vinblastine;6MP=6-mercaptopurine; Rad=radiation;Mtx=methotrexate;PiBr=piprobromine;Adr=adriamycin."]
["c \"UD\" in the histology column is undifferentiated"]
["d Ploidy information from the NCBI SKY/M-FISH and CGH Database (Roschke AV, Tonon G, et al, Cancer Res. 63 : 8634-8647, 2003)"]
["e p53 status as determined by yeast growth functional assay: PM O'Conner, et al. (Cancer Res. 1997 Oct 1;57(19):4285-300)."]
["f MDR Function: from DTP site (Lee JS etal., Mol Pharmacol. 1994 Oct;46(4):627-38)"]
["g Doubling times described at DPT."]
["h ME:LOXIMVI is amelanotic."]
["i ME:MDA_MB435 was apparently derived from the pleural effusion of a patient with breast cancer, and it has been reported to express some proteins characteristic of"]
["breast origin.  However, its molecular profiles in all of our databases (transcript expression, protein expression, drug sensitivity, etc.) are absolutely characteristic"]
["of melanotic melanoma (see, e.g., Scherf, et al., Nat. Genet. 24:236 (2000); Ross, et al., ibid, 24:227 (2000))."]
["j ME:MDA_N was derived from ME:MDA_MB_435 by transfection with a plasmid designed to express erbB2. ME:MDA_N and ME:MDA_MB_435 are very similar "]
["under non selective conditions."]
["k OV:NCI_ADR-RES (called NCI-ADR-RES in DTP tabulations) was derived from OVCAR8 by culturing with Adriamycin and is classically multi-drug resistant. It was originally "]
["called, MCF7_ADR-RES, then the agnostic NCI_ADR-RES, but our SKY (Roschke, et al., Cancer Res. 63:8634 (2003)) and CGH (Bussey, et al., Mol. Ca. Ther. 5:853 (2006))"]
["studies clearly showed its derivation from OVCAR8."]