{"text_format":"3","workbook":"xls","n_sheets":5,"sheets":["IVs in phylum","IVs in class","IVs in order","IVs in family","IVs in genus"],"read":"whole","date_system":"1900","formulas":"cached_only"}

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["Supplementary Table 1-1. Detailed information of instrumental variables in phylum used in MR analyses"]
["phylum","chr","SNP","other_allele","effect_allele","β","SE","P-value","F-statistics"]
["Actinobacteria.id.400",2,"rs7570971","C","A",0.086653038615226,0.0113622900572697,{"v":2.41454434302313e-14,"d":"2.41E-14"},58.1615335944839]
[null,2,"rs4429415","T","C",0.058190751763887,0.0111343348149913,{"v":1.72987942295314e-07,"d":"1.73E-07"},27.313627514461608]
[null,12,"rs10841473","C","G",-0.0596572414199823,0.0117536958993053,{"v":3.86243590431772e-07,"d":"3.86E-07"},25.76187298986975]
[null,14,"rs74037001","A","G",-0.0819391337306401,0.0165333681617048,{"v":7.19645639792687e-07,"d":"7.20E-07"},24.56179278883561]
[null,4,"rs55888705","G","A",0.0534221068088313,0.0109975291325724,{"v":1.18789355831892e-06,"d":"1.19E-06"},23.596727672061437]
[null,7,"rs62448869","A","T",-0.0524531242504281,0.0108225854238247,{"v":1.25572977107762e-06,"d":"1.26E-06"},23.489873460767406]
[null,16,"rs8047955","G","A",0.0521114930317853,0.0111192188342602,{"v":2.77761351670839e-06,"d":"2.78E-06"},21.96435615818712]
[null,3,"rs9833771","C","T",0.0490077063052793,0.0106564187700022,{"v":4.2474632359597e-06,"d":"4.25E-06"},21.149796644674407]
[null,5,"rs1397793","A","G",-0.0521386943335122,0.0111587375008764,{"v":2.97621321377924e-06,"d":"2.98E-06"},21.83183196171815]
[null,15,"rs6496870","C","T",0.0510776901466033,0.0113808759247108,{"v":7.18854728160556e-06,"d":"7.19E-06"},20.142395590611763]
[null,6,"rs857444","T","C",0.0507314925902726,0.0109884543965824,{"v":3.8970313751511e-06,"d":"3.90E-06"},21.31483915788918]
["Bacteroidetes.id.905",3,"rs73846128","G","A",-0.0664261813793914,0.0133481344502643,{"v":6.47645599232886e-07,"d":"6.48E-07"},24.764948493878087]
[null,13,"rs73512608","A","G",-0.123117207492397,0.0236743295721999,{"v":1.98804777760185e-07,"d":"1.99E-07"},27.04469789382551]
[null,14,"rs111845179","C","T",0.104176947845423,0.021383711519597,{"v":1.10591790781965e-06,"d":"1.11E-06"},23.734335936539637]
[null,17,"rs12938514","G","A",-0.201088983062079,0.0415994625645478,{"v":1.3386216979942e-06,"d":"1.34E-06"},23.36690085550866]
[null,2,"rs2032750","C","T",-0.0510856594263516,0.0106804228120142,{"v":1.72601814884329e-06,"d":"1.73E-06"},22.878161218834556]
[null,1,"rs7546249","A","T",-0.0569173305484821,0.0118382401001496,{"v":1.52507531359199e-06,"d":"1.53E-06"},23.116110326987197]
[null,9,"rs13291434","C","T",0.0705817932392667,0.0149780493078686,{"v":2.44877719649647e-06,"d":"2.45E-06"},22.206231563339273]
[null,9,"rs62575403","T","C",0.145423872299783,0.0311078671114559,{"v":2.9420265974873e-06,"d":"2.94E-06"},21.854000030571793]
["Cyanobacteria.id.1500",18,"rs789068","A","G",-0.111384961302318,0.0212921932638212,{"v":1.68360124126531e-07,"d":"1.68E-07"},27.36606269655955]
[null,3,"rs9864379","C","T",-0.138933303111685,0.0268044763106311,{"v":2.18096028049038e-07,"d":"2.18E-07"},26.865694311731243]
[null,7,"rs76531781","C","T",-0.231867724784247,0.0493392669768769,{"v":2.6085514125142e-06,"d":"2.61E-06"},22.084888706457004]
[null,6,"rs584122","T","C",-0.151773534809812,0.0326826549640266,{"v":3.41966384232335e-06,"d":"3.42E-06"},21.565396121619646]
[null,17,"rs2314810","G","C",-0.218256700359638,0.0464571432844159,{"v":2.62692611510993e-06,"d":"2.63E-06"},22.07141458607259]
[null,4,"rs2553290","T","A",0.0962131379743637,0.0202616703856865,{"v":2.04901082614303e-06,"d":"2.05E-06"},22.548531675848732]
["Euryarchaeota.id.55",2,"rs10202904","G","T",-0.115985759011108,0.0230270882566969,{"v":4.73065472861907e-07,"d":"4.73E-07"},25.37063204571708]
[null,13,"rs76029318","C","T",0.214866479448951,0.043844208631692,{"v":9.55050308538064e-07,"d":"9.55E-07"},24.01667409555814]
[null,3,"rs73031978","G","C",-0.197522680102211,0.0414497101795327,{"v":1.88519255038103e-06,"d":"1.89E-06"},22.70863045310696]
[null,6,"rs34928225","C","T",0.199769775438875,0.0425421346226176,{"v":2.65552470331966e-06,"d":"2.66E-06"},22.05063028819362]
[null,3,"rs7635189","A","G",0.119983323849168,0.0259356000874843,{"v":3.72432160587997e-06,"d":"3.72E-06"},21.401744535705575]
[null,6,"rs77658038","C","A",-0.16015667876191,0.0340856166915369,{"v":2.61875681514003e-06,"d":"2.62E-06"},22.077393399704505]
["Firmicutes.id.1672",2,"rs3792064","A","G",0.0897348641065787,0.0182532115465818,{"v":8.82791195976215e-07,"d":"8.83E-07"},24.16817431716819]
[null,17,"rs2009919","C","T",0.0536457183306855,0.0106294483522709,{"v":4.49046070311669e-07,"d":"4.49E-07"},25.47115729705201]
[null,21,"rs112334273","A","G",0.0627458974449614,0.0127415268240724,{"v":8.45678911824271e-07,"d":"8.46E-07"},24.250892414132327]
[null,12,"rs7975768","G","C",0.0512731716236811,0.0109226265307608,{"v":2.67630725953017e-06,"d":"2.68E-06"},22.03566677791587]
[null,4,"rs2332027","A","G",-0.0482656114142262,0.0104823006563359,{"v":4.13484922179411e-06,"d":"4.13E-06"},21.201295536144922]
[null,19,"rs7247191","C","T",-0.0713033009445312,0.0157424027760371,{"v":5.91574360281604e-06,"d":"5.92E-06"},20.515269753016074]
[null,20,"rs3852931","T","C",-0.0482086473600543,0.0104999905350889,{"v":4.40485423802763e-06,"d":"4.40E-06"},21.080071385262737]
[null,2,"rs7557870","A","T",0.0987372699023307,0.0187351682725343,{"v":1.36307447371681e-07,"d":"1.36E-07"},27.774550126477433]
["Lentisphaerae.id.2238",21,"rs2825714","G","A",-0.138226356654946,0.0289096212163607,{"v":1.74141703400369e-06,"d":"1.74E-06"},22.861089261392046]
[null,7,"rs11770843","T","C",0.111895531073448,0.0234776038396345,{"v":1.87868793562502e-06,"d":"1.88E-06"},22.715272104500873]
[null,20,"rs77599476","G","A",0.229981464318854,0.0479918178769902,{"v":1.65046760703711e-06,"d":"1.65E-06"},22.96419722133669]
[null,9,"rs62570196","T","C",-0.217203228881138,0.0439621393318696,{"v":7.78472583818507e-07,"d":"7.78E-07"},24.41040120169564]
[null,15,"rs1002941","A","G",0.107660546704916,0.0233381770380257,{"v":3.96772594658683e-06,"d":"3.97E-06"},21.280376223950917]
[null,5,"rs2731834","G","C",0.109934635507049,0.0236848450649918,{"v":3.45788152780841e-06,"d":"3.46E-06"},21.544081603754904]
["Proteobacteria.id.2375",3,"rs922773","T","C",-0.0803778142215572,0.0157851066327103,{"v":3.54300035603583e-07,"d":"3.54E-07"},25.92849706330052]
[null,10,"rs2532663","A","G",-0.125578004014177,0.02580335899182,{"v":1.13459360377333e-06,"d":"1.13E-06"},23.68506945870806]
[null,19,"rs12150865","T","C",0.0511615347978345,0.0106407186478985,{"v":1.52379031425102e-06,"d":"1.52E-06"},23.11773114171687]
[null,7,"rs2347697","T","G",0.0502280837908712,0.0108967825812913,{"v":4.03751771846297e-06,"d":"4.04E-06"},21.24695258674355]
[null,17,"rs312757","G","C",-0.0517268842465152,0.0112853758747855,{"v":4.57186338363707e-06,"d":"4.57E-06"},21.008767863285385]
["Tenericutes.id.3919",14,"rs74603314","C","T",0.221639279,0.046291765,{"v":1.69e-06,"d":"1.69E-06"},22.92376659472111]
[null,8,"rs10108398","A","G",0.076914215,0.015395275,{"v":5.85e-07,"d":"5.85E-07"},24.959640277771463]
[null,2,"rs67374027","T","A",0.075239233,0.015476642,{"v":1.17e-06,"d":"1.17E-06"},23.633891953228087]
[null,11,"rs72901605","C","T",-0.084185237,0.01781192,{"v":2.29e-06,"d":"2.29E-06"},22.338314752662296]
[null,1,"rs3768491","G","A",-0.068105197,0.01490611,{"v":4.9e-06,"d":"4.90E-06"},20.875258563860992]
[null,1,"rs12566890","G","T",-0.101147132,0.023097845,{"v":1.19e-05,"d":"1.19E-05"},19.176273742546826]
[null,20,"rs6043847","C","T",-0.11493717,0.024860602,{"v":3.78e-06,"d":"3.78E-06"},21.374586287741796]
["Verrucomicrobia.id.3982",4,"rs74542928","C","T",0.115994332706581,0.0231323719740418,{"v":5.32067865826812e-07,"d":"5.32E-07"},25.143932791407217]
[null,10,"rs11252894","C","A",0.0784054944572148,0.0162769170719171,{"v":1.45751307222466e-06,"d":"1.46E-06"},23.203243323692178]
[null,16,"rs2602429","T","C",0.0764148232973687,0.0153486720902809,{"v":6.4047479437524e-07,"d":"6.40E-07"},24.786408934376837]
[null,4,"rs11729256","C","T",0.0696984138682457,0.014695339825543,{"v":2.10688310723989e-06,"d":"2.11E-06"},22.495027216929532]
[null,1,"rs45598138","A","C",-0.143901453976954,0.0305400014508558,{"v":2.45416976041642e-06,"d":"2.45E-06"},22.202008133425625]
[null,5,"rs76430504","C","T",-0.117530088535779,0.0254580423138016,{"v":3.90041909480003e-06,"d":"3.90E-06"},21.313173416460987]
[null,18,"rs117107102","G","A",0.204282774850613,0.0427565053232772,{"v":1.77208196600192e-06,"d":"1.77E-06"},22.827539052734497]
[null,15,"rs12908520","A","G",0.0594915733402368,0.0128230120584656,{"v":3.49357406072609e-06,"d":"3.49E-06"},21.524387793654476]
["Notes: No. SNP is the number of SNPs being used as IVs, SE: stand error."]

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["Supplementary Table 1-2. Detailed information of instrumental variables in class used in MR analyses"]
["class","chr","NO.SNP","other_allele","effect_allele","β","SE","P-value","F-statistics"]
["Actinobacteria.id.419",2,"rs182549","T","C",0.111489457636552,0.0120659892001465,{"v":2.46551193540192e-20,"d":"2.47E-20"},85.37716721834653]
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["Alphaproteobacteria.id.2379",3,"rs9813022","G","A",-0.075127704449122,0.015386652361298,{"v":1.04667272921126e-06,"d":"1.05E-06"},23.84031309874983]
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["Bacilli.id.1673",8,"rs2952251","G","A",-0.0598867867493336,0.0123902722433435,{"v":1.34240049085301e-06,"d":"1.34E-06"},23.361478505308686]
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[null,16,"rs35344081","A","G",0.0619528936526956,0.0127066463159058,{"v":1.0846227204359e-06,"d":"1.08E-06"},23.771758438886856]
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[null,12,"rs11110282","G","A",-0.101189316290506,0.0217378828052513,{"v":3.24018914716346e-06,"d":"3.24E-06"},21.66879879440669]
[null,17,"rs4028634","C","T",0.0520614166569429,0.0109841630454299,{"v":2.14056125109574e-06,"d":"2.14E-06"},22.464565426908813]
[null,4,"rs4459992","C","T",0.0535854014625816,0.0116361814672868,{"v":4.12332032664903e-06,"d":"4.12E-06"},21.206646967251217]
["Bacteroidia.id.912",13,"rs55773148","A","G",-0.121513596767848,0.0236759029683016,{"v":2.86109748221659e-07,"d":"2.86E-07"},26.341266321237566]
[null,3,"rs73846128","G","A",-0.0648522757832394,0.0133490010926984,{"v":1.18450612450105e-06,"d":"1.18E-06"},23.60222273543319]
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[null,16,"rs929878","T","C",-0.0548532058638466,0.0121529540841487,{"v":6.37454733361887e-06,"d":"6.37E-06"},20.37231184094325]
[null,9,"rs13291434","C","T",0.069465573445222,0.014978948948469,{"v":3.52569173734408e-06,"d":"3.53E-06"},21.506838267585795]
["Betaproteobacteria.id.2867",4,"rs4033856","T","C",0.0832422652652502,0.016723677405277,{"v":6.44075798890865e-07,"d":"6.44E-07"},24.775602075949546]
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[null,20,"rs6087811","G","T",-0.0978177376981577,0.0198522012662304,{"v":8.33739852648462e-07,"d":"8.34E-07"},24.278278538516588]
[null,5,"rs62395635","C","T",0.109740893459822,0.0236000203820535,{"v":3.31880565833723e-06,"d":"3.32E-06"},21.62281473623117]
[null,7,"rs2613606","T","C",-0.051310588747841,0.0109091029016923,{"v":2.55782378463593e-06,"d":"2.56E-06"},22.122587376653527]
[null,1,"rs1928341","G","A",0.0525580967889223,0.0110407841601289,{"v":1.93248856697932e-06,"d":"1.93E-06"},22.661018279015206]
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["Deltaproteobacteria.id.3087",20,"rs6058181","T","C",0.082571565,0.016595819,{"v":6.51e-07,"d":"6.51E-07"},24.755041157175427]
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["Erysipelotrichia.id.2147",8,"rs62504403","T","C",0.0681158923407071,0.0127883386504578,{"v":1.00174712390254e-07,"d":"1.00E-07"},28.370608059777698]
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["Gammaproteobacteria.id.3303",2,"rs6706173","C","A",0.0742509648657476,0.0146392338141419,{"v":3.93547434866918e-07,"d":"3.94E-07"},25.725718226258046]
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[null,6,"rs9494710","T","C",-0.0549672529956779,0.0120923966452565,{"v":5.47778025409333e-06,"d":"5.48E-06"},20.662520563036804]
["Lentisphaeria.id.2250",21,"rs2825714","G","A",-0.137410136,0.02892458,{"v":2.03e-06,"d":"2.03E-06"},22.56853746643038]
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[null,9,"rs62570196","T","C",-0.216350467,0.043986577,{"v":8.72e-07,"d":"8.72E-07"},24.192198666280685]
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[null,13,"rs2031282","G","A",0.122368503,0.027032933,{"v":5.99e-06,"d":"5.99E-06"},20.490518974879777]
["Melainabacteria.id.1589",3,"rs9864379","C","T",-0.159734555,0.029255297,{"v":4.76e-08,"d":"4.76E-08"},29.81183641952132]
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[null,15,"rs79790072","C","T",0.226721783,0.048784054,{"v":3.36e-06,"d":"3.36E-06"},21.598854613768832]
["Methanobacteria.id.119",2,"rs10202904","G","T",-0.12175357919406,0.0235356821452398,{"v":2.30181906393081e-07,"d":"2.30E-07"},26.761465582381085]
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[null,4,"rs894996","A","C",0.216999068802611,0.0449075536099716,{"v":1.35081030097521e-06,"d":"1.35E-06"},23.349465655133773]
["Mollicutes.id.3920",14,"rs74603314","C","T",0.221639278654774,0.0462917653779854,{"v":1.68554898916383e-06,"d":"1.69E-06"},22.923766148950744]
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["Negativicutes.id.2164",5,"rs1643968","C","T",-0.0565284394558359,0.0112298063077143,{"v":4.80887003853824e-07,"d":"4.81E-07"},25.338999415117616]
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["Verrucomicrobiae.id.4029",4,"rs11729256","C","T",0.0749798022294282,0.0150176770445129,{"v":5.95195281171737e-07,"d":"5.95E-07"},24.927748823230466]
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[null,18,"rs117107102","G","A",0.204682880450429,0.0431572505321698,{"v":2.10864610037714e-06,"d":"2.11E-06"},22.49342051727713]
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[null,12,"rs111862613","C","T",0.0906989568997961,0.0196745959705639,{"v":4.02760587635448e-06,"d":"4.03E-06"},21.2516639355479]
["Notes: No. SNP is the number of SNPs being used as IVs, SE: stand error."]

{"sheet":"IVs in order","index":2,"n_rows":155,"n_cols":9,"rows_kept":155,"merged":[[0,0,0,8],[2,0,3,0],[4,0,8,0],[9,0,16,0],[17,0,27,0],[28,0,37,0],[38,0,44,0],[45,0,50,0],[51,0,59,0],[60,0,63,0],[64,0,71,0],[72,0,78,0],[79,0,90,0],[91,0,94,0],[95,0,98,0],[99,0,109,0],[110,0,119,0],[120,0,128,0],[129,0,136,0],[137,0,146,0],[147,0,153,0],[154,0,156,8]],"flags":["formulas_cached_only"]}
["Supplementary Table 1-3. Detailed information of instrumental variables in order used in MR analyses"]
["order","chr","NO.SNP","other_allele","effect_allele","β","SE","P-value","F-statistics"]
["Actinomycetales.id.420",6,"rs35011108","G","A",0.24154595,0.050380314,{"v":1.63e-06,"d":"1.63E-06"},22.98676099329899]
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["Bacillales.id.1674",21,"rs74887130","G","C",-0.19216577548202,0.0358817122772681,{"v":8.53035064569712e-08,"d":"8.53E-08"},28.681757978398124]
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["Bacteroidales.id.913",13,"rs55773148","A","G",-0.121513596767848,0.0236759029683016,{"v":2.86109748221659e-07,"d":"2.86E-07"},26.341266321237566]
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["Bifidobacteriales.id.432",2,"rs182549","T","C",0.117069879249602,0.0126703401741303,{"v":2.47237241848798e-20,"d":"2.47E-20"},85.37167271908419]
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[null,6,"rs857444","T","C",0.0553965097207252,0.0120669365001091,{"v":4.4161734034275e-06,"d":"4.42E-06"},21.07515370443711]
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[null,2,"rs7588568","C","A",-0.0607159543226153,0.0130605062233713,{"v":3.33837923528683e-06,"d":"3.34E-06"},21.61153577937449]
["Burkholderiales.id.2874",2,"rs62191117","G","A",0.0679994877788782,0.0132470587328011,{"v":2.84892828128365e-07,"d":"2.85E-07"},26.34949880827361]
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[null,3,"rs2367850","C","G",0.0633300429163297,0.0130595216192062,{"v":1.23873783792802e-06,"d":"1.24E-06"},23.516085325898803]
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["Notes: No. SNP is the number of SNPs being used as IVs, SE: stand error."]

{"sheet":"IVs in family","index":3,"n_rows":246,"n_cols":9,"rows_kept":246,"merged":[[0,0,0,8],[2,0,6,0],[7,0,8,0],[9,0,20,0],[21,0,27,0],[28,0,32,0],[33,0,43,0],[44,0,46,0],[47,0,48,0],[49,0,59,0],[60,0,65,0],[66,0,73,0],[74,0,82,0],[83,0,86,0],[87,0,94,0],[95,0,101,0],[102,0,110,0],[111,0,118,0],[119,0,125,0],[126,0,129,0],[130,0,136,0],[137,0,146,0],[147,0,154,0],[155,0,165,0],[166,0,171,0],[172,0,180,0],[181,0,187,0],[188,0,199,0],[200,0,204,0],[205,0,215,0],[216,0,224,0],[225,0,234,0],[235,0,244,0],[245,0,247,8]],"flags":["formulas_cached_only"]}
["Supplementary Table 1-4. Detailed information of instrumental variables in family used in MR analyses"]
["family","chr","NO.SNP","other_allele","effect_allele","β","SE","P-value","F-statistics"]
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[null,4,"rs1442060","A","G",-0.0514024324748101,0.0112124520131324,{"v":4.55278807430415e-06,"d":"4.55E-06"},21.016778529100087]
[null,15,"rs4461038","G","A",-0.055496494470622,0.0119467363626548,{"v":3.39538551823817e-06,"d":"3.40E-06"},21.579060979759365]
["Verrucomicrobiaceae.id.4036",4,"rs11729256","C","T",0.0749798022294282,0.0150176770445129,{"v":5.95195281171737e-07,"d":"5.95E-07"},24.927748823230466]
[null,11,"rs4936098","G","A",0.0648690999836486,0.0135928078815882,{"v":1.82124425878011e-06,"d":"1.82E-06"},22.774947652963117]
[null,6,"rs9349825","G","A",-0.0704354054632216,0.0147127959281481,{"v":1.68992132207797e-06,"d":"1.69E-06"},22.918786321156585]
[null,4,"rs74542928","C","T",0.112123955601894,0.0236421776623845,{"v":2.11055916852503e-06,"d":"2.11E-06"},22.491678570913972]
[null,16,"rs2602429","T","C",0.0745515638137895,0.015619484092786,{"v":1.81515284264043e-06,"d":"1.82E-06"},22.78138613486184]
[null,10,"rs4242783","A","G",0.0687992076094732,0.014769359950755,{"v":3.18925917803654e-06,"d":"3.19E-06"},21.699190001940345]
[null,1,"rs11184341","C","G",0.0655300751917741,0.0142230476539083,{"v":4.07899851988107e-06,"d":"4.08E-06"},21.22736083215327]
[null,18,"rs117107102","G","A",0.204682880450429,0.0431572505321698,{"v":2.10864610037714e-06,"d":"2.11E-06"},22.49342051727713]
[null,15,"rs12908520","A","G",0.061910393948464,0.0130946089802172,{"v":2.26820407346452e-06,"d":"2.27E-06"},22.35332158853427]
[null,12,"rs111862613","C","T",0.0907064965869101,0.0196746301357261,{"v":4.02034309787579e-06,"d":"4.02E-06"},21.25512350954432]
["Victivallaceae.id.2255",11,"rs4396289","T","C",-0.152917575095274,0.0288525324220802,{"v":1.15821296306571e-07,"d":"1.16E-07"},28.08968892027984]
[null,7,"rs34296005","A","T",0.127902874966482,0.0257465622023387,{"v":6.77289091888741e-07,"d":"6.77E-07"},24.678690788303673]
[null,7,"rs2944282","C","T",-0.124196623325255,0.025702577448202,{"v":1.35121520366078e-06,"d":"1.35E-06"},23.348889173021163]
[null,2,"rs6545794","G","A",-0.197785619878533,0.041049540870068,{"v":1.44846360578861e-06,"d":"1.45E-06"},23.215220743868816]
[null,5,"rs2546105","T","A",0.126643494725124,0.025711059028846,{"v":8.40834449850054e-07,"d":"8.41E-07"},24.261957736246938]
[null,9,"rs62570196","T","C",-0.246101492410071,0.0483077156271041,{"v":3.49745548531698e-07,"d":"3.50E-07"},25.95347364422027]
[null,10,"rs7077363","A","G",0.148942159891761,0.0318366217930646,{"v":2.89223601394671e-06,"d":"2.89E-06"},21.88675309067375]
[null,2,"rs67832247","T","C",-0.123489124096538,0.0266695070307709,{"v":3.65049990360715e-06,"d":"3.65E-06"},21.440131475016475]
[null,2,"rs61702987","C","T",0.145501293186444,0.0300007330024392,{"v":1.23508410858343e-06,"d":"1.24E-06"},23.52176868384477]
[null,19,"rs11671100","C","A",-0.160034432207544,0.0349472360870359,{"v":4.66499291916101e-06,"d":"4.66E-06"},20.97013367515487]
["Notes: No. SNP is the number of SNPs being used as IVs, SE: stand error."]

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["Supplementary Table 1-5. Detailed information of instrumental variables in genus used in MR analyses"]
["genus","chr","NO.SNP","other_allele","effect_allele","β","SE","P-value","F-statistics"]
["Clostridiuminnocuumgroup.id.14397",5,"rs6890185","C","T",0.113423667539842,0.0233137293961593,{"v":1.14397893557269e-06,"d":"1.14E-06"},23.66921581228882]
[null,3,"rs1948423","A","T",-0.108859115491909,0.0234249758961361,{"v":3.36570634089393e-06,"d":"3.37E-06"},21.595899469222733]
[null,18,"rs1942371","A","G",-0.157937950060136,0.0341869571277657,{"v":3.84053510275999e-06,"d":"3.84E-06"},21.3428346106422]
["Eubacteriumbrachygroup.id.11296",10,"rs55932844","G","A",-0.1707050270079,0.036102310836577,{"v":2.26331208375571e-06,"d":"2.26E-06"},22.3574680617331]
[null,22,"rs9613196","A","T",-0.238718472435947,0.0528561035322752,{"v":6.29044819945366e-06,"d":"6.29E-06"},20.39772651017842]
[null,5,"rs62348779","C","T",-0.201480568519595,0.0432860149871789,{"v":3.24556290496083e-06,"d":"3.25E-06"},21.665620133378084]
[null,10,"rs2913110","T","C",0.105143062329495,0.0229419728069847,{"v":4.58351948952989e-06,"d":"4.58E-06"},21.003889381584493]
[null,4,"rs4862235","A","G",0.104806298434417,0.0225751345578332,{"v":3.44127389835557e-06,"d":"3.44E-06"},21.55331471412076]
["Eubacteriumcoprostanoligenesgroup.id.11375",7,"rs17159861","T","C",0.0962227578374938,0.0168388279036101,{"v":1.10131765909294e-08,"d":"1.10E-08"},32.65366127076084]
[null,7,"rs9648214","C","T",-0.0828719424900575,0.0164309869258978,{"v":4.5676416611731e-07,"d":"4.57E-07"},25.438279641865307]
[null,15,"rs12906958","T","C",-0.0533159248785428,0.0115934765314648,{"v":4.24958739808131e-06,"d":"4.25E-06"},21.14883847653631]
[null,1,"rs11808093","C","T",0.0790287154428198,0.0173724029301444,{"v":5.38770570297908e-06,"d":"5.39E-06"},20.69426748475179]
[null,15,"rs4076415","G","T",0.0515152023270292,0.0110294347490564,{"v":3.00172219532892e-06,"d":"3.00E-06"},21.81545665255682]
[null,3,"rs6762473","A","C",0.0521583647345351,0.0112352505249882,{"v":3.44409414570336e-06,"d":"3.44E-06"},21.55174363344149]
[null,7,"rs73109678","A","G",-0.0796955987438092,0.0172275163130711,{"v":3.72679584818935e-06,"d":"3.73E-06"},21.400471203245598]
[null,3,"rs76898927","A","G",0.123055019732079,0.0266374911785224,{"v":3.84448163227562e-06,"d":"3.84E-06"},21.34086561311197]
["Eubacteriumeligensgroup.id.14372",16,"rs4583233","C","A",0.0670204772475218,0.0128121779815614,{"v":1.68597344490104e-07,"d":"1.69E-07"},27.363339953788554]
[null,10,"rs265534","G","T",-0.0563756083216695,0.0120127195063776,{"v":2.692367320178e-06,"d":"2.69E-06"},22.02418311621303]
[null,2,"rs72839198","G","C",0.155658995251687,0.0375612220523567,{"v":3.41090039328467e-05,"d":"3.41E-05"},17.17390351010518]
[null,14,"rs74606150","G","C",-0.196453544549325,0.0425649510311357,{"v":3.92371343435522e-06,"d":"3.92E-06"},21.301758754297392]
[null,6,"rs6923695","G","T",0.103267603329869,0.0229524502317044,{"v":6.82105124101435e-06,"d":"6.82E-06"},20.24277682223029]
["Eubacteriumfissicatenagroup.id.14373",2,"rs3771393","T","C",0.130842344234957,0.026667104373126,{"v":9.27125050934809e-07,"d":"9.27E-07"},24.07381460559173]
[null,8,"rs2733072","A","G",0.109644167948117,0.022830586609729,{"v":1.56687364686323e-06,"d":"1.57E-06"},23.064122262309617]
[null,11,"rs7104872","A","G",0.138611742742229,0.0291905525245554,{"v":2.04916864610366e-06,"d":"2.05E-06"},22.548383715392454]
[null,7,"rs151257695","G","A",0.209509778724955,0.0454847225801605,{"v":4.10178515865783e-06,"d":"4.10E-06"},21.216683406252873]
[null,18,"rs11876297","C","T",0.131469397810945,0.0281712031830947,{"v":3.05925432213429e-06,"d":"3.06E-06"},21.77903111799869]
["Eubacteriumhalliigroup.id.11338",4,"rs13116360","C","T",0.154124444645952,0.0297185330554663,{"v":2.14698538206535e-07,"d":"2.15E-07"},26.896038196473036]
[null,3,"rs949971","G","T",-0.0540163641850448,0.0116100708747731,{"v":3.27864941395863e-06,"d":"3.28E-06"},21.646164547513536]
[null,1,"rs10798999","T","C",0.0601660737633011,0.0126752446850334,{"v":2.06722788169552e-06,"d":"2.07E-06"},22.531527750471472]
[null,7,"rs60254196","G","A",-0.0522831629686655,0.0111864909683667,{"v":2.95710568036341e-06,"d":"2.96E-06"},21.84419041793217]
[null,7,"rs10808115","C","A",-0.0504747407839271,0.0109922475222328,{"v":4.39336204189486e-06,"d":"4.39E-06"},21.085077231457163]
[null,15,"rs74018587","T","C",0.208942799186401,0.0438219737316112,{"v":1.86071612936378e-06,"d":"1.86E-06"},22.73374314445716]
[null,3,"rs6550770","C","T",-0.198087408104575,0.0443544874600637,{"v":7.96933673877631e-06,"d":"7.97E-06"},19.945209789588848]
[null,3,"rs28584818","G","A",0.126115363898252,0.0268627474424814,{"v":2.668610271651e-06,"d":"2.67E-06"},22.041194998739048]
["Eubacteriumnodatumgroup.id.11297",14,"rs34297067","G","A",-0.186906548469567,0.0341474916846643,{"v":4.41214446791952e-08,"d":"4.41E-08"},29.95928327135712]
[null,9,"rs77910827","T","C",0.201788440873475,0.041356826061215,{"v":1.06514199499156e-06,"d":"1.07E-06"},23.80664340732611]
[null,10,"rs61841040","T","G",0.16062114062078,0.0341609285495782,{"v":2.57756514380047e-06,"d":"2.58E-06"},22.10782800909771]
["Eubacteriumoxidoreducensgroup.id.11339",12,"rs12423772","T","G",0.140979641070221,0.0295028890109047,{"v":1.76605205362774e-06,"d":"1.77E-06"},22.834090086212054]
[null,4,"rs2973294","T","G",0.0923558710698249,0.0195438711807532,{"v":2.29474250610876e-06,"d":"2.29E-06"},22.330982681216636]
[null,16,"rs34561138","A","G",0.21614534542657,0.0459919696239924,{"v":2.60630348233756e-06,"d":"2.61E-06"},22.0865436409693]
[null,5,"rs440215","T","C",0.093276592479957,0.019529390755972,{"v":1.78624347070284e-06,"d":"1.79E-06"},22.812241176989136]
["Eubacteriumrectalegroup.id.14374",15,"rs35398954","G","A",-0.0901401557711116,0.0174601710173563,{"v":2.43522556261196e-07,"d":"2.44E-07"},26.65260249343869]
[null,12,"rs117151453","C","G",-0.113140608673848,0.0243541400411959,{"v":3.39020964480995e-06,"d":"3.39E-06"},21.58198685469096]
[null,18,"rs16960159","G","C",-0.156595964289606,0.0336233795397446,{"v":3.20300200658044e-06,"d":"3.20E-06"},21.690941598571868]
[null,2,"rs314726","C","T",0.0528823543475253,0.0109486239549705,{"v":1.3650169916622e-06,"d":"1.37E-06"},23.32934172252007]
[null,1,"rs10797540","G","A",0.0503179066833849,0.0108389459069818,{"v":3.44510838717875e-06,"d":"3.45E-06"},21.551178943544965]
[null,7,"rs10248854","A","C",-0.0527826766524865,0.0113463501938763,{"v":3.28807601059493e-06,"d":"3.29E-06"},21.64065755411668]
["Eubacteriumruminantiumgroup.id.11340",5,"rs2116427","G","A",0.0911460512715159,0.0182353068079111,{"v":5.78294474859752e-07,"d":"5.78E-07"},24.98328644932824]
[null,22,"rs139749","T","C",-0.0845439274477069,0.0171790775197909,{"v":8.59575921699328e-07,"d":"8.60E-07"},24.219499211566283]
[null,10,"rs72836424","T","C",-0.139824589058134,0.0300689633359883,{"v":3.31725834301736e-06,"d":"3.32E-06"},21.623709196464215]
[null,9,"rs2229917","G","A",0.153537928651796,0.032392214867845,{"v":2.13756314871157e-06,"d":"2.14E-06"},22.467257637850313]
[null,14,"rs10131724","C","A",-0.199832279489332,0.041457713434255,{"v":1.43452366385964e-06,"d":"1.43E-06"},23.233818601994045]
[null,5,"rs16891896","A","G",-0.174787011436225,0.0390572683191562,{"v":7.6358811018979e-06,"d":"7.64E-06"},20.026939363014325]
[null,8,"rs7000472","G","A",-0.0762282078264311,0.0165230216194415,{"v":3.96031061494989e-06,"d":"3.96E-06"},21.2839620788091]
[null,9,"rs606117","G","A",0.0833242657046866,0.0180559868547672,{"v":3.93526757485761e-06,"d":"3.94E-06"},21.29612221444732]
[null,6,"rs57340348","C","T",-0.0979429331387566,0.0212165948394574,{"v":3.90574176683814e-06,"d":"3.91E-06"},21.310559189337088]
[null,12,"rs17519472","T","C",0.107804140148699,0.0233983775447583,{"v":4.07864600156534e-06,"d":"4.08E-06"},21.227526485910996]
["Eubacteriumventriosumgroup.id.11341",20,"rs6048195","T","A",-0.0603594315178333,0.0116579938541485,{"v":2.24861545144937e-07,"d":"2.25E-07"},26.806655773342495]
[null,20,"rs73615400","C","T",-0.0956303165866365,0.0193427596489153,{"v":7.65415340688097e-07,"d":"7.65E-07"},24.442989225980888]
[null,3,"rs57199565","C","T",0.0783394354345015,0.0160257103081581,{"v":1.0167965448018e-06,"d":"1.02E-06"},23.896059946657846]
[null,13,"rs11617697","G","A",-0.143348528477697,0.0286240730320826,{"v":5.50068116617877e-07,"d":"5.50E-07"},25.07977382766973]
[null,8,"rs16884680","T","G",-0.090642842676102,0.019190901440616,{"v":2.32139897897076e-06,"d":"2.32E-06"},22.308803808281407]
[null,18,"rs12964517","A","G",0.0587198057553738,0.0123453323838013,{"v":1.9703889967103e-06,"d":"1.97E-06"},22.623700662007202]
[null,12,"rs876734","T","C",-0.0618696480882828,0.0132532314306121,{"v":3.03748188592849e-06,"d":"3.04E-06"},21.79273450597868]
[null,14,"rs3809430","C","T",-0.0548171139338207,0.0118425655148259,{"v":3.67753772720459e-06,"d":"3.68E-06"},21.42598227479953]
[null,1,"rs78250280","A","G",0.0749762423694705,0.0164404475269874,{"v":5.10381505664612e-06,"d":"5.10E-06"},20.797928028012336]
["Eubacteriumxylanophilumgroup.id.14375",20,"rs17830032","A","G",-0.160597430862368,0.0310514530483689,{"v":2.31628907911223e-07,"d":"2.32E-07"},26.749356042120738]
[null,7,"rs13239072","A","G",0.06874273429727,0.0142728315744079,{"v":1.46219168968793e-06,"d":"1.46E-06"},23.19708015717151]
[null,17,"rs79582700","G","C",-0.0951676506584881,0.0199968965266752,{"v":1.94437831261992e-06,"d":"1.94E-06"},22.649232913289577]
[null,11,"rs2213117","G","T",0.0877797364305482,0.0189012284695105,{"v":3.41514735028632e-06,"d":"3.42E-06"},21.56793080723209]
[null,14,"rs10140184","C","A",0.0576794526232797,0.0125989898497408,{"v":4.69215322443156e-06,"d":"4.69E-06"},20.959012104261536]
[null,1,"rs10917203","C","A",0.0612633267044508,0.0130916884542897,{"v":2.87492817606753e-06,"d":"2.87E-06"},21.898271128364968]
[null,16,"rs112176119","T","C",-0.113455468153488,0.024576195578986,{"v":3.90307229201633e-06,"d":"3.90E-06"},21.311869853091984]
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["Turicibacter.id.2162",2,"rs149744580","G","A",0.169882696026826,0.0315478367777077,{"v":7.2475359395477e-08,"d":"7.25E-08"},28.997403964491056]
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["Veillonella.id.2198",11,"rs2013594","C","T",-0.0720698188103724,0.0155153201517585,{"v":3.39953667879313e-06,"d":"3.40E-06"},21.57671759801276]
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["Victivallis.id.2256",11,"rs56349194","G","A",-0.158501176425758,0.0315230753399211,{"v":4.95363437006908e-07,"d":"4.95E-07"},25.281790027617205]
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["Notes: No. SNP is the number of SNPs being used as IVs, SE: stand error."]