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["Supplementary Table 3. Detailed information of instrumental variables of gut microbiome on five BMDs"]
["BMD_names","Feature","Taxa","NO.SNP","Chr","Effect_allele","Other_allele","Exposure",null,null,"Outcome",null,null,"F-statistics"]
[{"$nulls":7},"β","SE","P-value","β","SE","P-value"]
["FABMD","class","Actinobacteria","rs11745923",5,"G","T",0.0563758629126231,0.0115529083776643,{"v":1.06194378542852e-06,"d":"1.06E-06"},0.015026,0.015992,0.356912698601902,23.812431660924833]
["FABMD","class","Actinobacteria","rs134366",22,"G","A",0.111876588900405,0.0235009749396161,{"v":1.93105884611147e-06,"d":"1.93E-06"},0.027347,0.038861,0.490209812218608,22.66244034483946]
["FABMD","class","Actinobacteria","rs1515761",10,"T","C",0.076231730501034,0.0169884018217099,{"v":7.21379464698616e-06,"d":"7.21E-06"},0.009981,0.023232,0.673587470203853,20.135689603416328]
["FABMD","class","Actinobacteria","rs182549",2,"C","T",0.111489457636552,0.0120659892001465,{"v":2.46551193540192e-20,"d":"2.47E-20"},-0.014971,0.023776,0.536979863302311,85.37716721834653]
["FABMD","class","Actinobacteria","rs1961273",2,"C","T",0.0602969391703004,0.0126047003106014,{"v":1.72108747123354e-06,"d":"1.72E-06"},-0.018135,0.018311,0.331489670525724,22.883659913995157]
["FABMD","class","Actinobacteria","rs6660520",1,"A","G",0.0711482708585258,0.0134495387497714,{"v":1.22305875052729e-07,"d":"1.22E-07"},-0.005221,0.019525,0.793165836753445,27.984265881640635]
["FABMD","class","Actinobacteria","rs72767435",15,"T","C",-0.126352155578809,0.0273625975662218,{"v":3.88024248431932e-06,"d":"3.88E-06"},-0.067104,0.035199,0.0615956439639116,21.323115756967187]
["FABMD","class","Actinobacteria","rs7322849",13,"T","C",0.0944466808134731,0.0192975980696832,{"v":9.86966335064834e-07,"d":"9.87E-07"},0.014853,0.026985,0.589424250601382,23.953384533286428]
["FABMD","class","Actinobacteria","rs8047955",16,"A","G",0.0575815497040898,0.011676216345728,{"v":8.15902344318323e-07,"d":"8.16E-07"},-0.004241,0.015984,0.794744077134548,24.319936198334567]
["FABMD","class","Alphaproteobacteria","rs140912403",9,"C","T",-0.160677132788545,0.0317707558663604,{"v":4.25031357071426e-07,"d":"4.25E-07"},0.031267,0.031689,0.333312038723917,25.57720309231586]
["FABMD","class","Alphaproteobacteria","rs76784716",2,"A","G",0.13327129852031,0.0267737610045454,{"v":6.4349888299476e-07,"d":"6.43E-07"},0.031506,0.030649,0.313469289832056,24.777329358055386]
["FABMD","class","Alphaproteobacteria","rs9813022",3,"A","G",-0.075127704449122,0.015386652361298,{"v":1.04667272921126e-06,"d":"1.05E-06"},-0.029306,0.016798,0.0871645715977069,23.84031309874983]
["FABMD","class","Bacilli","rs11110282",12,"A","G",-0.101189316290506,0.0217378828052513,{"v":3.24018914716346e-06,"d":"3.24E-06"},0.014574,0.032012,0.655343505654115,21.66879879440669]
["FABMD","class","Bacilli","rs11730038",4,"G","A",-0.0630746834241007,0.0128717370396616,{"v":9.57165232292883e-07,"d":"9.57E-07"},-0.003377,0.018179,0.855472001088214,24.012415034830717]
["FABMD","class","Bacilli","rs2952251",8,"A","G",-0.0598867867493336,0.0123902722433435,{"v":1.34240049085301e-06,"d":"1.34E-06"},-0.004107,0.01827,0.825536918614834,23.361478505308686]
["FABMD","class","Bacilli","rs35344081",16,"G","A",0.0619528936526956,0.0127066463159058,{"v":1.0846227204359e-06,"d":"1.08E-06"},-0.016934,0.018332,0.365070718025488,23.771758438886856]
["FABMD","class","Bacilli","rs4028634",17,"T","C",0.0520614166569429,0.0109841630454299,{"v":2.14056125109574e-06,"d":"2.14E-06"},0.010579,0.015985,0.516417558366074,22.464565426908813]
["FABMD","class","Bacilli","rs4459992",4,"T","C",0.0535854014625816,0.0116361814672868,{"v":4.12332032664903e-06,"d":"4.12E-06"},0.028382,0.016669,0.0950189003414025,21.206646967251217]
["FABMD","class","Bacilli","rs57872228",1,"C","T",-0.0714773356616873,0.0146646952055786,{"v":1.09300149801796e-06,"d":"1.09E-06"},-0.041084,0.02133,0.0589562701207529,23.756947037883585]
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["FABMD","class","Bacilli","rs9581006",13,"C","T",0.22530905432439,0.0467697047842467,{"v":1.45430369768493e-06,"d":"1.45E-06"},{"v":-4.9e-05,"d":"-4.90E-05"},0.041346,0.999071000222702,23.20748253403655]
["FABMD","class","Bacteroidia","rs111845179",14,"T","C",0.102647804394865,0.0213842813280857,{"v":1.58545117201038e-06,"d":"1.59E-06"},-0.007823,0.033115,0.816809913353031,23.041460843467025]
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["FABMD","class","Bacteroidia","rs13291434",9,"T","C",0.069465573445222,0.014978948948469,{"v":3.52569173734408e-06,"d":"3.53E-06"},0.037031,0.021187,0.086572508162901,21.506838267585795]
["FABMD","class","Bacteroidia","rs2032750",2,"T","C",-0.0508392764927297,0.0106807311325787,{"v":1.93683117170513e-06,"d":"1.94E-06"},0.000937,0.015515,0.952783000749117,22.65670538765515]
["FABMD","class","Bacteroidia","rs55773148",13,"G","A",-0.121513596767848,0.0236759029683016,{"v":2.86109748221659e-07,"d":"2.86E-07"},0.104243,0.035818,0.00433401090766375,26.341266321237566]
["FABMD","class","Bacteroidia","rs73846128",3,"A","G",-0.0648522757832394,0.0133490010926984,{"v":1.18450612450105e-06,"d":"1.18E-06"},-0.018024,0.020493,0.38846956564841,23.60222273543319]
["FABMD","class","Bacteroidia","rs929878",16,"C","T",-0.0548532058638466,0.0121529540841487,{"v":6.37454733361887e-06,"d":"6.37E-06"},0.001521,0.017746,0.932993031446844,20.37231184094325]
["FABMD","class","Betaproteobacteria","rs11128180",3,"A","G",0.0592944116737909,0.0128769228748097,{"v":4.13053958298778e-06,"d":"4.13E-06"},0.014015,0.018184,0.449837855390422,21.20329421057399]
["FABMD","class","Betaproteobacteria","rs1511453",4,"A","G",0.0923492456668957,0.0199158272522817,{"v":3.53540638844557e-06,"d":"3.54E-06"},0.055455,0.031695,0.086242234425396,21.501561641293176]
["FABMD","class","Betaproteobacteria","rs1928341",1,"A","G",0.0525580967889223,0.0110407841601289,{"v":1.93248856697932e-06,"d":"1.93E-06"},-0.016456,0.015639,0.302171151798151,22.661018279015206]
["FABMD","class","Betaproteobacteria","rs2613606",7,"C","T",-0.051310588747841,0.0109091029016923,{"v":2.55782378463593e-06,"d":"2.56E-06"},-0.01341,0.015501,0.396288983973447,22.122587376653527]
["FABMD","class","Betaproteobacteria","rs4033856",4,"C","T",0.0832422652652502,0.016723677405277,{"v":6.44075798890865e-07,"d":"6.44E-07"},0.023057,0.024358,0.353324700910795,24.775602075949546]
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["FABMD","class","Betaproteobacteria","rs62395635",5,"T","C",0.109740893459822,0.0236000203820535,{"v":3.31880565833723e-06,"d":"3.32E-06"},-0.001382,0.03025,0.964255889193448,21.62281473623117]
["FABMD","class","Betaproteobacteria","rs9964679",18,"A","G",0.0529110285262687,0.0114865910212846,{"v":4.09837867919707e-06,"d":"4.10E-06"},0.025257,0.016856,0.141760096441479,21.218275834059686]
["FABMD","class","Clostridia","rs10774377",12,"A","G",0.0526590075575969,0.0113858338043842,{"v":3.74673612840856e-06,"d":"3.75E-06"},-0.005088,0.016802,0.766522663484067,21.390240090436045]
["FABMD","class","Clostridia","rs112334273",21,"G","A",0.0641008116927255,0.0127403663613056,{"v":4.87123966999302e-07,"d":"4.87E-07"},0.028768,0.019536,0.148766107588127,25.31414272424931]
["FABMD","class","Clostridia","rs13179700",5,"T","C",0.0511936668802236,0.0109568653813725,{"v":2.97858099618294e-06,"d":"2.98E-06"},-0.019835,0.016421,0.236241939802339,21.83030606332484]
["FABMD","class","Clostridia","rs6814436",4,"T","C",0.0739994805048434,0.0150815142256241,{"v":9.26523818074208e-07,"d":"9.27E-07"},0.001914,0.02234,0.933028908677266,24.075063738841482]
["FABMD","class","Clostridia","rs6815608",4,"T","C",0.103803178927405,0.0210882992549549,{"v":8.55279117764535e-07,"d":"8.55E-07"},-0.036642,0.034859,0.302680888402067,24.229150964865433]
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["FABMD","class","Coriobacteriia","rs11250875",10,"T","C",0.0607499778487578,0.0130938873723768,{"v":3.49138629492573e-06,"d":"3.49E-06"},-0.011255,0.019317,0.567834793554591,21.525589100833457]
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["FABMD","class","Deltaproteobacteria","rs2692012",1,"A","G",0.110334899713198,0.0253335744958444,{"v":1.32894791404213e-05,"d":"1.33E-05"},0.042182,0.031494,0.189067116177346,18.968494611360697]
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["FABMD","class","Deltaproteobacteria","rs6058181",20,"C","T",0.0825715653635653,0.0165958193892764,{"v":6.50983466707953e-07,"d":"6.51E-07"},0.026564,0.023854,0.27485016372125,24.755040213846954]
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["TBBMD","phylum","Firmicutes","rs7247191",19,"T","C",-0.0713033009445312,0.0157424027760371,{"v":5.91574360281604e-06,"d":"5.92E-06"},0.006,0.0087,0.489599538760826,20.515269753016074]
["TBBMD","phylum","Lentisphaerae","rs1002941",15,"G","A",0.107660546704916,0.0233381770380257,{"v":3.96772594658683e-06,"d":"3.97E-06"},{"v":0.0002,"d":"2.00E-04"},0.0066,0.979700004401403,21.280376223950917]
["TBBMD","phylum","Lentisphaerae","rs11770843",7,"C","T",0.111895531073448,0.0234776038396345,{"v":1.87868793562502e-06,"d":"1.88E-06"},0.0069,0.0066,0.297700113346316,22.715272104500873]
["TBBMD","phylum","Lentisphaerae","rs2825714",21,"A","G",-0.138226356654946,0.0289096212163607,{"v":1.74141703400369e-06,"d":"1.74E-06"},0.0146,0.0084,0.0836604121912303,22.861089261392046]
["TBBMD","phylum","Lentisphaerae","rs62570196",9,"C","T",-0.217203228881138,0.0439621393318696,{"v":7.78472583818507e-07,"d":"7.78E-07"},-0.0041,0.0117,0.728200545615682,24.41040120169564]
["TBBMD","phylum","Lentisphaerae","rs77599476",20,"A","G",0.229981464318854,0.0479918178769902,{"v":1.65046760703711e-06,"d":"1.65E-06"},0.0122,0.0136,0.371600252138891,22.96419722133669]
["TBBMD","phylum","Proteobacteria","rs12150865",19,"C","T",0.0511615347978345,0.0106407186478985,{"v":1.52379031425102e-06,"d":"1.52E-06"},0.0044,0.0062,0.483300227977574,23.11773114171687]
["TBBMD","phylum","Proteobacteria","rs2347697",7,"G","T",0.0502280837908712,0.0108967825812913,{"v":4.03751771846297e-06,"d":"4.04E-06"},-0.0157,0.006,0.00882795274971182,21.24695258674355]
["TBBMD","phylum","Proteobacteria","rs2532663",10,"G","A",-0.125578004014177,0.02580335899182,{"v":1.13459360377333e-06,"d":"1.13E-06"},-0.0169,0.0133,0.203899893997845,23.68506945870806]
["TBBMD","phylum","Proteobacteria","rs922773",3,"C","T",-0.0803778142215572,0.0157851066327103,{"v":3.54300035603583e-07,"d":"3.54E-07"},-0.0027,0.0085,0.75259962918202,25.92849706330052]
["TBBMD","phylum","Tenericutes","rs10108398",8,"G","A",0.0769142148997625,0.0153952747324077,{"v":5.85430435491848e-07,"d":"5.85E-07"},0.0045,0.0068,0.506000562934156,24.959641080384593]
["TBBMD","phylum","Tenericutes","rs12566890",1,"T","G",-0.101147131791056,0.0230978446219969,{"v":1.19185583647237e-05,"d":"1.19E-05"},0.013,0.0109,0.234599995797614,19.17627429097116]
["TBBMD","phylum","Tenericutes","rs3768491",1,"A","G",-0.0681051974734089,0.0149061101163454,{"v":4.90185354026458e-06,"d":"4.90E-06"},0.0165,0.0063,0.00863594762945724,20.875258528202988]
["TBBMD","phylum","Tenericutes","rs6043847",20,"T","C",-0.114937169898503,0.0248606017200305,{"v":3.77745168527624e-06,"d":"3.78E-06"},0.0087,0.0113,0.441999725872037,21.374586731414453]
["TBBMD","phylum","Tenericutes","rs72901605",11,"T","C",-0.0841852374505514,0.0178119197664198,{"v":2.28599692080953e-06,"d":"2.29E-06"},-0.0064,0.0076,0.401399659733332,22.338315577643368]
["TBBMD","phylum","Tenericutes","rs74603314",14,"T","C",0.221639278654774,0.0462917653779854,{"v":1.68554898916383e-06,"d":"1.69E-06"},-0.014,0.0137,0.307599765469361,22.923766148950744]
["TBBMD","phylum","Verrucomicrobia","rs11252894",10,"A","C",0.0784054944572148,0.0162769170719171,{"v":1.45751307222466e-06,"d":"1.46E-06"},{"v":-0.0009,"d":"-9.00E-04"},0.0075,0.903999936564408,23.203243323692178]
["TBBMD","phylum","Verrucomicrobia","rs117107102",18,"A","G",0.204282774850613,0.0427565053232772,{"v":1.77208196600192e-06,"d":"1.77E-06"},0.0017,0.0149,0.90879996156553,22.827539052734497]
["TBBMD","phylum","Verrucomicrobia","rs11729256",4,"T","C",0.0696984138682457,0.014695339825543,{"v":2.10688310723989e-06,"d":"2.11E-06"},0.0087,0.0067,0.193900085240888,22.495027216929532]
["TBBMD","phylum","Verrucomicrobia","rs12908520",15,"G","A",0.0594915733402368,0.0128230120584656,{"v":3.49357406072609e-06,"d":"3.49E-06"},0.0158,0.0058,0.0062769692339914,21.524387793654476]
["TBBMD","phylum","Verrucomicrobia","rs2602429",16,"C","T",0.0764148232973687,0.0153486720902809,{"v":6.4047479437524e-07,"d":"6.40E-07"},-0.0034,0.0072,0.638500144668586,24.786408934376837]
["TBBMD","phylum","Verrucomicrobia","rs45598138",1,"C","A",-0.143901453976954,0.0305400014508558,{"v":2.45416976041642e-06,"d":"2.45E-06"},-0.0038,0.0136,0.782200339294915,22.202008133425625]
["TBBMD","phylum","Verrucomicrobia","rs74542928",4,"T","C",0.115994332706581,0.0231323719740418,{"v":5.32067865826812e-07,"d":"5.32E-07"},-0.0124,0.01,0.21549986379281,25.143932791407217]
["TBBMD","phylum","Verrucomicrobia","rs76430504",5,"T","C",-0.117530088535779,0.0254580423138016,{"v":3.90041909480003e-06,"d":"3.90E-06"},-0.0104,0.0122,0.395099972997265,21.313173416460987]
["Notes: No. SNP is the number of SNPs being used as IVs, SE: stand error."]