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["Table S1 Instrumental variables used in MR analysis (systemic inflammatory regulators on POI)."]
["Systemic inflammatory regulators (exposure)","Abbreviation","SNP","Effect allele","Other allele","Exposure (systemic inflammatory regulators)",null,null,"Outcome (POI)",null,null,"F"]
[{"$nulls":5},"Beta","SE","P-value","Beta","SE","P-value"]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs116303454","A","G",0.383,0.082,{"v":3.27e-06,"d":"3.27E-06"},0.025,0.288,{"v":0.93,"d":"0.930"},{"v":22.03,"d":"22.030"}]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs145902143","G","A",0.284,0.058,{"v":1.03e-06,"d":"1.03E-06"},0.239,0.233,0.304,{"v":23.86,"d":"23.860"}]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs2070074","G","A",-0.447,0.037,{"v":1.78e-32,"d":"1.78E-32"},-0.074,0.143,0.604,142.656]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs2731674","G","T",0.133,0.027,{"v":5.63e-07,"d":"5.63E-07"},-0.146,0.101,0.149,24.925]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs3766110","C","A",0.129,0.028,{"v":3.85e-06,"d":"3.85E-06"},-0.001,0.105,0.992,21.432]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs55764737","C","T",-0.531,0.097,{"v":4.62e-08,"d":"4.62E-08"},0.728,{"v":0.35,"d":"0.350"},0.038,29.878]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs57338032","G","A",-0.158,0.032,{"v":6.23e-07,"d":"6.23E-07"},0.045,0.119,0.707,24.937]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs7333764","T","C",0.277,0.059,{"v":2.85e-06,"d":"2.85E-06"},0.008,0.236,0.975,21.867]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs76395525","A","G",0.528,0.108,{"v":9.55e-07,"d":"9.55E-07"},0.205,0.453,0.651,23.742]
["Beta nerve growth factor","bNGF","rs28637706","T","G",-0.159,0.026,{"v":1.42e-09,"d":"1.42E-09"},-0.064,0.097,0.511,36.504]
["Beta nerve growth factor","bNGF","rs67476890","T","C",0.177,0.038,{"v":3.13e-06,"d":"3.13E-06"},-0.046,0.142,0.745,21.786]
["Beta nerve growth factor","bNGF","rs71641308","T","C",0.204,0.043,{"v":2.3e-06,"d":"2.30E-06"},0.144,0.152,0.344,22.365]
["Beta nerve growth factor","bNGF","rs72780728","A","G",0.188,{"v":0.04,"d":"0.040"},{"v":2.99e-06,"d":"2.99E-06"},0.261,0.154,{"v":0.09,"d":"0.090"},21.832]
["Beta nerve growth factor","bNGF","rs73472576","C","T",0.118,0.025,{"v":2.69e-06,"d":"2.69E-06"},0.099,0.091,0.276,21.963]
["Beta nerve growth factor","bNGF","rs7970581","G","T",-0.138,0.028,{"v":9.27e-07,"d":"9.27E-07"},0.052,0.101,0.606,23.947]
["Beta nerve growth factor","bNGF","rs9436119","A","G",-0.112,0.025,{"v":3.91e-06,"d":"3.91E-06"},0.023,0.091,0.801,20.765]
["Vascular endothelial growth factor","VEGF","rs10153304","A","G",0.155,0.033,{"v":1.94e-06,"d":"1.94E-06"},-0.283,0.162,{"v":0.08,"d":"0.080"},22.658]
["Vascular endothelial growth factor","VEGF","rs10934631","C","T",0.115,0.025,{"v":2.47e-06,"d":"2.47E-06"},{"v":-0.02,"d":"-0.020"},0.126,0.874,22.071]
["Vascular endothelial growth factor","VEGF","rs10967186","C","T",{"v":-0.09,"d":"-0.090"},0.017,{"v":1.23e-07,"d":"1.23E-07"},0.173,{"v":0.09,"d":"0.090"},0.056,27.903]
["Vascular endothelial growth factor","VEGF","rs13209117","A","G",{"v":0.13,"d":"0.130"},{"v":0.02,"d":"0.020"},{"v":5.28e-11,"d":"5.28E-11"},-0.088,0.103,0.394,41.959]
["Vascular endothelial growth factor","VEGF","rs143479231","A","G",{"v":-0.26,"d":"-0.260"},0.049,{"v":1.9e-07,"d":"1.90E-07"},-0.019,0.225,0.933,27.997]
["Vascular endothelial growth factor","VEGF","rs4082730","A","G",0.252,0.053,{"v":2.64e-06,"d":"2.64E-06"},0.181,0.281,{"v":0.52,"d":"0.520"},22.305]
["Vascular endothelial growth factor","VEGF","rs6921438","A","G",{"v":-0.49,"d":"-0.490"},0.018,{"v":2.09e-171,"d":"2.09E-171"},0.164,{"v":0.09,"d":"0.090"},0.068,{"v":784,"d":"784.000"}]
["Vascular endothelial growth factor","VEGF","rs73418461","A","G",-0.249,0.052,{"v":1.67e-06,"d":"1.67E-06"},-0.056,0.266,0.833,22.878]
["Vascular endothelial growth factor","VEGF","rs8045833","A","G",0.108,0.021,{"v":2.83e-07,"d":"2.83E-07"},0.097,0.108,{"v":0.37,"d":"0.370"},26.199]
["Vascular endothelial growth factor","VEGF","rs9472183","G","A",0.128,0.017,{"v":5.19e-14,"d":"5.19E-14"},0.023,{"v":0.09,"d":"0.090"},0.796,56.869]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs113218956","A","G",-0.895,0.188,{"v":2.26e-06,"d":"2.26E-06"},0.501,0.713,0.482,22.678]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs118055855","C","T",-0.691,{"v":0.15,"d":"0.150"},{"v":4.13e-06,"d":"4.13E-06"},-0.283,0.497,0.569,21.203]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs12594190","G","A",-0.136,0.027,{"v":3.7e-07,"d":"3.70E-07"},0.141,0.098,0.151,25.755]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs13142904","T","C",-0.223,0.043,{"v":2.56e-07,"d":"2.56E-07"},-0.191,0.159,0.231,27.532]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs141009259","C","T",0.618,0.132,{"v":2.47e-06,"d":"2.47E-06"},-0.013,0.422,0.975,21.839]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs78098071","C","T",0.487,0.092,{"v":1.78e-07,"d":"1.78E-07"},0.608,0.349,0.081,28.108]
["TNF-related apoptosis inducing ligand","TRAIL","rs11618126","G","A",-0.891,0.191,{"v":1.46e-06,"d":"1.46E-06"},-1.069,1.006,0.288,21.661]
["TNF-related apoptosis inducing ligand","TRAIL","rs11657269","G","A",-0.119,0.026,{"v":4.78e-06,"d":"4.78E-06"},0.012,0.146,0.937,20.878]
["TNF-related apoptosis inducing ligand","TRAIL","rs11699445","G","T",-0.075,0.016,{"v":3.27e-06,"d":"3.27E-06"},0.048,{"v":0.09,"d":"0.090"},0.599,{"v":21.47,"d":"21.470"}]
["TNF-related apoptosis inducing ligand","TRAIL","rs13185784","A","G",0.085,0.018,{"v":3.9e-06,"d":"3.90E-06"},0.079,0.102,0.442,21.372]
["TNF-related apoptosis inducing ligand","TRAIL","rs13278062","T","G",{"v":0.08,"d":"0.080"},0.016,{"v":3.57e-07,"d":"3.57E-07"},0.087,{"v":0.09,"d":"0.090"},{"v":0.33,"d":"0.330"},26.029]
["TNF-related apoptosis inducing ligand","TRAIL","rs138987090","G","A",{"v":0.75,"d":"0.750"},0.075,{"v":4.5e-23,"d":"4.50E-23"},-0.738,0.387,0.057,99.389]
["TNF-related apoptosis inducing ligand","TRAIL","rs146783010","G","A",0.602,0.135,{"v":4.83e-06,"d":"4.83E-06"},{"v":0.47,"d":"0.470"},0.636,{"v":0.46,"d":"0.460"},19.859]
["TNF-related apoptosis inducing ligand","TRAIL","rs193112415","C","T",1.042,0.062,{"v":2.15e-62,"d":"2.15E-62"},0.011,0.324,0.972,279.797]
["TNF-related apoptosis inducing ligand","TRAIL","rs57396456","C","T",0.563,0.052,{"v":1.25e-27,"d":"1.25E-27"},-0.163,0.296,0.581,117.961]
["TNF-related apoptosis inducing ligand","TRAIL","rs62093514","T","C",1.062,0.055,{"v":6.86e-82,"d":"6.86E-82"},0.068,0.303,0.822,370.005]
["TNF-related apoptosis inducing ligand","TRAIL","rs73039026","C","A",{"v":0.3,"d":"0.300"},0.064,{"v":2.02e-06,"d":"2.02E-06"},-0.126,0.321,0.694,22.305]
["TNF-related apoptosis inducing ligand","TRAIL","rs747324","C","T",0.086,0.018,{"v":1.61e-06,"d":"1.61E-06"},0.028,0.099,0.777,23.072]
["TNF-related apoptosis inducing ligand","TRAIL","rs74778900","T","C",0.591,0.053,{"v":2.59e-28,"d":"2.59E-28"},0.469,0.392,0.232,123.243]
["TNF-related apoptosis inducing ligand","TRAIL","rs75928541","A","G",0.275,0.059,{"v":4.24e-06,"d":"4.24E-06"},0.064,0.302,0.833,21.506]
["TNF-related apoptosis inducing ligand","TRAIL","rs79287178","A","G",-0.432,0.042,{"v":9.12e-25,"d":"9.12E-25"},-0.227,0.228,0.321,105.148]
["Tumor necrosis factor-beta","TNFb","rs10925040","T","C",0.176,0.037,{"v":2.67e-06,"d":"2.67E-06"},0.042,0.093,0.653,22.138]
["Tumor necrosis factor-beta","TNFb","rs753274","T","C",-0.174,0.037,{"v":2.77e-06,"d":"2.77E-06"},-0.265,0.092,0.004,21.895]
["Tumor necrosis factor-beta","TNFb","rs7629875","G","A",-0.377,0.077,{"v":1.37e-06,"d":"1.37E-06"},-0.095,0.187,0.614,23.674]
["Tumor necrosis factor-beta","TNFb","rs78296352","T","G",1.222,0.137,{"v":4.76e-21,"d":"4.76E-21"},-0.313,0.385,0.416,79.962]
["Tumor necrosis factor-alpha","TNFa","rs10834997","A","G",-0.125,0.026,{"v":1.33e-06,"d":"1.33E-06"},0.053,0.097,0.586,23.361]
["Tumor necrosis factor-alpha","TNFa","rs111332265","G","A",0.377,0.075,{"v":6.63e-07,"d":"6.63E-07"},0.169,0.241,0.482,24.947]
["Tumor necrosis factor-alpha","TNFa","rs115669577","A","G",0.989,{"v":0.2,"d":"0.200"},{"v":8.28e-07,"d":"8.28E-07"},-0.031,0.696,0.964,24.571]
["Tumor necrosis factor-alpha","TNFa","rs79105320","A","G",0.561,0.118,{"v":3.59e-06,"d":"3.59E-06"},-0.173,0.417,0.678,22.601]
["Tumor necrosis factor-alpha","TNFa","rs8121916","A","C",0.131,0.028,{"v":2.72e-06,"d":"2.72E-06"},0.074,0.103,0.473,{"v":22.07,"d":"22.070"}]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs10474392","G","A",-0.096,0.018,{"v":1.24e-06,"d":"1.24E-06"},-0.036,0.102,0.726,29.209]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs12407262","A","G",0.118,0.027,{"v":3.99e-06,"d":"3.99E-06"},0.239,0.145,0.098,19.646]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs13400104","G","A",0.065,0.019,{"v":4.53e-06,"d":"4.53E-06"},0.078,{"v":0.1,"d":"0.100"},0.439,11.719]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs139840550","A","G",0.183,0.055,{"v":3.79e-06,"d":"3.79E-06"},0.086,0.329,0.794,{"v":11.16,"d":"11.160"}]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs149893336","G","A",0.503,0.108,{"v":4.52e-06,"d":"4.52E-06"},0.164,0.419,0.695,21.686]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs4581824","G","T",{"v":0.07,"d":"0.070"},0.017,{"v":3.05e-06,"d":"3.05E-06"},0.168,0.094,0.075,16.419]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs482700","A","G",-0.089,{"v":0.02,"d":"0.020"},{"v":1.57e-06,"d":"1.57E-06"},0.038,0.112,0.735,19.351]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs67689854","A","C",-0.068,{"v":0.02,"d":"0.020"},{"v":3.07e-06,"d":"3.07E-06"},-0.082,0.112,{"v":0.46,"d":"0.460"},12.196]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs9267091","A","G",0.078,{"v":0.02,"d":"0.020"},{"v":3.63e-06,"d":"3.63E-06"},-0.043,0.113,0.706,14.802]
["Stem cell growth factor beta","SCGFb","rs112346514","T","C",-0.331,0.071,{"v":2.37e-06,"d":"2.37E-06"},-0.037,0.237,0.877,21.725]
["Stem cell growth factor beta","SCGFb","rs116924815","T","C",0.608,0.074,{"v":1.74e-16,"d":"1.74E-16"},0.154,0.274,0.575,{"v":67.85,"d":"67.850"}]
["Stem cell growth factor beta","SCGFb","rs117716477","A","C",0.838,0.084,{"v":1.34e-23,"d":"1.34E-23"},-0.305,0.353,0.387,99.383]
["Stem cell growth factor beta","SCGFb","rs12480722","C","T",-0.162,0.036,{"v":4.72e-06,"d":"4.72E-06"},-0.172,0.135,0.201,20.927]
["Stem cell growth factor beta","SCGFb","rs139413256","A","G",-0.538,0.108,{"v":7.04e-07,"d":"7.04E-07"},-0.105,{"v":0.34,"d":"0.340"},0.757,24.605]
["Stem cell growth factor beta","SCGFb","rs143829871","C","T",{"v":0.19,"d":"0.190"},{"v":0.04,"d":"0.040"},{"v":1.9e-06,"d":"1.90E-06"},-0.092,0.154,{"v":0.55,"d":"0.550"},{"v":22.61,"d":"22.610"}]
["Stem cell growth factor beta","SCGFb","rs151194174","A","G",0.464,0.094,{"v":1.13e-06,"d":"1.13E-06"},-0.285,0.236,0.228,{"v":24.21,"d":"24.210"}]
["Stem cell growth factor beta","SCGFb","rs17876031","G","A",0.151,0.026,{"v":2.25e-09,"d":"2.25E-09"},-0.114,0.096,0.233,35.251]
["Stem cell growth factor beta","SCGFb","rs264162","G","A",{"v":-0.11,"d":"-0.110"},0.023,{"v":2.68e-06,"d":"2.68E-06"},0.009,0.089,{"v":0.92,"d":"0.920"},21.978]
["Stem cell growth factor beta","SCGFb","rs34911860","A","G",-0.368,0.079,{"v":3.24e-06,"d":"3.24E-06"},-0.068,0.348,0.844,21.695]
["Stem cell growth factor beta","SCGFb","rs4656185","A","G",0.205,0.026,{"v":1.16e-15,"d":"1.16E-15"},-0.027,0.097,0.785,64.125]
["Stem cell growth factor beta","SCGFb","rs4737732","G","A",0.115,0.025,{"v":4.68e-06,"d":"4.68E-06"},0.028,0.099,0.778,20.717]
["Stem cell growth factor beta","SCGFb","rs7762066","C","T",-0.139,{"v":0.03,"d":"0.030"},{"v":3.5e-06,"d":"3.50E-06"},0.061,0.106,0.566,21.581]
["Stem cell growth factor beta","SCGFb","rs78217154","C","T",{"v":-0.4,"d":"-0.400"},0.086,{"v":3.77e-06,"d":"3.77E-06"},0.085,0.323,0.792,21.401]
["Stem cell factor","SCF","rs113127926","A","C",0.198,0.042,{"v":2.27e-06,"d":"2.27E-06"},-0.166,0.229,0.469,22.269]
["Stem cell factor","SCF","rs13412535","A","G",-0.107,0.021,{"v":6.04e-07,"d":"6.04E-07"},-0.135,0.112,0.228,25.094]
["Stem cell factor","SCF","rs1557570","T","G",0.119,0.017,{"v":2.74e-12,"d":"2.74E-12"},-0.021,0.097,0.826,48.671]
["Stem cell factor","SCF","rs1568119","T","C",-0.591,0.113,{"v":1.24e-07,"d":"1.24E-07"},2.081,0.668,0.002,27.365]
["Stem cell factor","SCF","rs1942355","T","C",-0.072,0.016,{"v":4.7e-06,"d":"4.70E-06"},-0.071,0.089,0.428,20.798]
["Stem cell factor","SCF","rs4841899","C","T",{"v":0.1,"d":"0.100"},0.018,{"v":1.78e-08,"d":"1.78E-08"},0.013,0.102,0.898,31.815]
["Stem cell factor","SCF","rs635634","T","C",-0.103,0.019,{"v":6.74e-08,"d":"6.74E-08"},{"v":0.12,"d":"0.120"},0.112,0.281,29.194]
["Stem cell factor","SCF","rs78666213","G","T",0.274,0.058,{"v":2.59e-06,"d":"2.59E-06"},-0.189,0.308,0.539,22.695]
["Stem cell factor","SCF","rs80271436","A","G",-0.237,0.049,{"v":9.95e-07,"d":"9.95E-07"},-0.405,0.271,0.135,23.879]
["Interleukin-16","IL-16","rs117217798","T","C",-0.204,0.044,{"v":4.15e-06,"d":"4.15E-06"},0.154,0.161,0.338,21.028]
["Interleukin-16","IL-16","rs117916513","A","G",-0.502,0.099,{"v":3.79e-07,"d":"3.79E-07"},0.162,0.345,0.639,25.921]
["Interleukin-16","IL-16","rs1255143","T","C",0.131,0.024,{"v":7.1e-08,"d":"7.10E-08"},-0.097,{"v":0.09,"d":"0.090"},0.283,29.124]
["Interleukin-16","IL-16","rs12765671","A","G",-0.602,0.132,{"v":4.84e-06,"d":"4.84E-06"},0.348,0.483,0.471,20.883]
["Interleukin-16","IL-16","rs144691581","A","G",0.488,0.097,{"v":4.2e-07,"d":"4.20E-07"},-0.363,0.315,0.249,25.488]
["Interleukin-16","IL-16","rs1801020","G","A",-0.173,0.027,{"v":4.53e-10,"d":"4.53E-10"},-0.154,0.101,0.127,40.594]
["Interleukin-16","IL-16","rs4253283","C","T",-0.146,0.026,{"v":1.75e-08,"d":"1.75E-08"},0.027,0.097,0.783,31.053]
["Interleukin-16","IL-16","rs4513633","A","C",-0.224,0.045,{"v":7.44e-07,"d":"7.44E-07"},-0.104,0.166,0.531,24.429]
["Interleukin-16","IL-16","rs4778636","A","G",-0.727,0.063,{"v":1.11e-30,"d":"1.11E-30"},0.029,0.215,0.892,131.978]
["Interleukin-16","IL-16","rs9706053","T","C",0.458,0.093,{"v":7.01e-07,"d":"7.01E-07"},0.849,0.354,0.016,{"v":24.17,"d":"24.170"}]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs112072646","A","G",0.429,0.086,{"v":6.48e-07,"d":"6.48E-07"},-0.352,0.331,0.287,24.722]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs147509526","T","C",-0.358,0.072,{"v":6.93e-07,"d":"6.93E-07"},{"v":-0.34,"d":"-0.340"},{"v":0.26,"d":"0.260"},0.191,{"v":24.93,"d":"24.930"}]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs4940620","G","A",0.249,0.054,{"v":3.54e-06,"d":"3.54E-06"},0.586,0.203,0.004,21.331]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs62438851","G","A",0.196,0.041,{"v":2.33e-06,"d":"2.33E-06"},{"v":0.07,"d":"0.070"},0.148,0.638,22.345]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs7000423","T","C",-0.132,0.025,{"v":1.82e-07,"d":"1.82E-07"},-0.203,0.093,0.029,27.139]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs72793342","A","G",-0.149,0.031,{"v":1.48e-06,"d":"1.48E-06"},-0.035,{"v":0.11,"d":"0.110"},{"v":0.75,"d":"0.750"},23.309]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs74472919","T","C",0.331,0.061,{"v":3.97e-08,"d":"3.97E-08"},-0.306,0.232,0.187,29.987]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs75613039","T","C",{"v":0.37,"d":"0.370"},0.081,{"v":4.81e-06,"d":"4.81E-06"},0.095,0.274,0.728,20.866]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs818452","T","C",0.238,0.051,{"v":2.36e-06,"d":"2.36E-06"},0.126,0.184,0.494,{"v":22.23,"d":"22.230"}]
["Platelet derived growth factor BB","PDGFbb","rs116445074","T","G",0.293,0.059,{"v":3.11e-07,"d":"3.11E-07"},0.315,0.335,0.347,24.932]
["Platelet derived growth factor BB","PDGFbb","rs11766649","G","A",-0.091,{"v":0.02,"d":"0.020"},{"v":3.53e-06,"d":"3.53E-06"},0.027,0.111,0.805,21.461]
["Platelet derived growth factor BB","PDGFbb","rs11916118","G","A",-0.089,0.019,{"v":4.93e-06,"d":"4.93E-06"},0.007,0.113,0.954,20.999]
["Platelet derived growth factor BB","PDGFbb","rs12289510","G","A",0.078,0.016,{"v":7.69e-07,"d":"7.69E-07"},0.175,{"v":0.09,"d":"0.090"},{"v":0.05,"d":"0.050"},24.371]
["Platelet derived growth factor BB","PDGFbb","rs13412535","A","G",0.335,0.021,{"v":2.4599999999999997e-55,"d":"2.46E-55"},-0.135,0.112,0.228,245.347]
["Platelet derived growth factor BB","PDGFbb","rs2324229","C","T",-0.089,0.016,{"v":3.48e-08,"d":"3.48E-08"},{"v":0.08,"d":"0.080"},0.093,0.385,30.834]
["Platelet derived growth factor BB","PDGFbb","rs35859699","A","G",-0.395,0.084,{"v":2.07e-06,"d":"2.07E-06"},0.429,0.408,0.293,{"v":22.03,"d":"22.030"}]
["Platelet derived growth factor BB","PDGFbb","rs4965869","T","C",0.184,0.018,{"v":5.6599999999999994e-24,"d":"5.66E-24"},0.148,0.103,0.151,103.342]
["Platelet derived growth factor BB","PDGFbb","rs55680718","T","C",-0.138,0.025,{"v":1.86e-08,"d":"1.86E-08"},{"v":0.18,"d":"0.180"},0.136,0.187,31.606]
["Platelet derived growth factor BB","PDGFbb","rs72777070","G","T",0.107,{"v":0.02,"d":"0.020"},{"v":8.98e-08,"d":"8.98E-08"},{"v":-0.02,"d":"-0.020"},0.111,0.857,28.569]
["Platelet derived growth factor BB","PDGFbb","rs73162807","A","C",-0.239,{"v":0.05,"d":"0.050"},{"v":1.74e-06,"d":"1.74E-06"},-0.082,0.289,0.776,22.959]
["Platelet derived growth factor BB","PDGFbb","rs9936075","G","A",0.078,0.016,{"v":1.76e-06,"d":"1.76E-06"},0.035,0.094,0.709,22.737]
["Platelet derived growth factor BB","PDGFbb","rs9941733","G","A",-0.116,0.023,{"v":3.31e-07,"d":"3.31E-07"},0.014,0.118,0.906,{"v":25.93,"d":"25.930"}]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs11130043","A","G",-0.073,0.016,{"v":3.22e-06,"d":"3.22E-06"},-0.109,{"v":0.09,"d":"0.090"},0.229,21.679]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs113010081","C","T",0.595,0.024,{"v":3.8499999999999996e-140,"d":"3.85E-140"},-0.021,0.134,0.878,636.493]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs113877493","T","C",-0.612,0.022,{"v":1.6200000000000002e-173,"d":"1.62E-173"},0.174,0.123,0.156,789.146]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs116237296","A","G",0.544,0.112,{"v":7.23e-07,"d":"7.23E-07"},-0.293,0.616,0.634,23.778]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs117453826","G","A",0.577,0.059,{"v":5.07e-22,"d":"5.07E-22"},-0.593,{"v":0.3,"d":"0.300"},0.048,94.808]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs141102180","T","G",0.323,0.039,{"v":1.08e-16,"d":"1.08E-16"},0.167,0.234,0.476,{"v":67.34,"d":"67.340"}]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs17138331","G","A",0.139,{"v":0.03,"d":"0.030"},{"v":2.26e-06,"d":"2.26E-06"},-0.355,0.161,0.028,22.234]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs17641689","G","A",0.245,0.029,{"v":1.28e-16,"d":"1.28E-16"},-0.072,0.144,0.618,69.805]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs2079664","G","A",{"v":-0.1,"d":"-0.100"},0.018,{"v":1.51e-08,"d":"1.51E-08"},-0.026,0.101,0.799,31.961]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs281749","C","T",{"v":-0.08,"d":"-0.080"},0.017,{"v":3.17e-06,"d":"3.17E-06"},-0.215,0.097,0.027,21.832]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs34437725","C","T",0.263,0.048,{"v":7.67e-08,"d":"7.67E-08"},0.239,0.267,0.371,29.717]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs72791296","T","C",0.237,0.047,{"v":3.78e-07,"d":"3.78E-07"},0.087,0.248,0.727,25.844]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs72799710","T","C",-0.101,0.022,{"v":3.21e-06,"d":"3.21E-06"},0.161,0.124,0.194,21.635]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs74810984","C","T",-0.221,0.047,{"v":1.96e-06,"d":"1.96E-06"},-0.199,0.287,0.488,{"v":21.66,"d":"21.660"}]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs76582507","A","G",0.318,0.068,{"v":3.26e-06,"d":"3.26E-06"},-0.513,{"v":0.5,"d":"0.500"},0.306,21.994]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs76583883","T","G",-0.232,0.051,{"v":4.99e-06,"d":"4.99E-06"},0.037,0.241,0.879,20.559]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","rs76776296","G","A",{"v":-0.3,"d":"-0.300"},{"v":0.06,"d":"0.060"},{"v":5.55e-07,"d":"5.55E-07"},0.221,0.309,0.474,25.117]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs10835056","G","T",-0.119,0.025,{"v":2.6e-06,"d":"2.60E-06"},-0.118,0.095,0.214,22.097]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs12690897","A","G",0.125,0.026,{"v":2.11e-06,"d":"2.11E-06"},-0.001,0.098,0.995,{"v":22.69,"d":"22.690"}]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs184154340","A","G",0.331,0.069,{"v":1.86e-06,"d":"1.86E-06"},-0.508,0.231,0.028,22.813]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs34771762","G","A",-0.249,0.052,{"v":2.13e-06,"d":"2.13E-06"},0.092,0.173,0.594,22.667]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs57786342","A","G",0.131,0.029,{"v":4.05e-06,"d":"4.05E-06"},-0.003,0.118,0.982,21.257]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs60198979","A","G",-0.215,0.046,{"v":2.61e-06,"d":"2.61E-06"},-0.184,0.169,0.276,21.955]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","rs7232268","G","A",-0.282,{"v":0.06,"d":"0.060"},{"v":2.55e-06,"d":"2.55E-06"},{"v":0.28,"d":"0.280"},0.227,0.218,{"v":22.18,"d":"22.180"}]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs111607343","A","G",-0.521,0.112,{"v":2.83e-06,"d":"2.83E-06"},1.163,0.396,0.003,21.678]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs11177248","A","G",0.307,0.067,{"v":4.45e-06,"d":"4.45E-06"},{"v":-0.06,"d":"-0.060"},0.225,0.792,21.037]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs112337562","G","T",{"v":0.37,"d":"0.370"},{"v":0.08,"d":"0.080"},{"v":2.98e-06,"d":"2.98E-06"},-0.084,0.288,0.772,21.606]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs112861654","G","A",0.277,0.053,{"v":1.81e-07,"d":"1.81E-07"},-0.254,0.186,0.172,{"v":27.32,"d":"27.320"}]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs117831247","T","C",-0.833,0.175,{"v":2.16e-06,"d":"2.16E-06"},-0.004,0.664,0.996,22.576]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs139010077","T","C",0.432,0.095,{"v":3.55e-06,"d":"3.55E-06"},-0.169,0.353,0.631,20.698]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs1796086","C","T",{"v":0.21,"d":"0.210"},{"v":0.04,"d":"0.040"},{"v":2.23e-07,"d":"2.23E-07"},0.032,0.161,0.842,{"v":27.05,"d":"27.050"}]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs41272086","A","G",-0.223,0.042,{"v":7.43e-08,"d":"7.43E-08"},0.025,0.148,0.867,28.771]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs55876513","G","T",-0.166,0.026,{"v":8.23e-11,"d":"8.23E-11"},-0.121,0.099,0.223,42.378]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs5752128","C","T",0.169,0.037,{"v":4.34e-06,"d":"4.34E-06"},0.128,0.137,{"v":0.35,"d":"0.350"},20.852]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs62562991","A","G",0.624,0.126,{"v":8.4e-07,"d":"8.40E-07"},-0.071,{"v":0.37,"d":"0.370"},0.848,24.495]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs6679677","A","C",0.162,0.033,{"v":8.86e-07,"d":"8.86E-07"},0.146,0.126,0.247,24.246]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs77086208","T","C",0.323,{"v":0.07,"d":"0.070"},{"v":3.83e-06,"d":"3.83E-06"},{"v":-0.22,"d":"-0.220"},0.274,0.422,21.361]
["Monokine induced by interferon-gamma (CXCL9)","MIG","rs816960","T","C",-0.122,0.024,{"v":5.01e-07,"d":"5.01E-07"},0.131,0.094,0.162,25.164]
["Macrophage colony-stimulating factor","MCSF","rs116274860","G","T",-0.819,0.174,{"v":2.74e-06,"d":"2.74E-06"},-0.287,0.405,0.479,22.129]
["Macrophage colony-stimulating factor","MCSF","rs117867915","C","T",-0.527,{"v":0.11,"d":"0.110"},{"v":1.61e-06,"d":"1.61E-06"},-0.202,0.327,0.536,23.054]
["Macrophage colony-stimulating factor","MCSF","rs12962919","T","C",0.305,0.066,{"v":4.65e-06,"d":"4.65E-06"},0.126,0.176,0.473,21.255]
["Macrophage colony-stimulating factor","MCSF","rs145778765","T","C",-0.799,0.169,{"v":2.2e-06,"d":"2.20E-06"},0.532,0.322,0.098,22.395]
["Macrophage colony-stimulating factor","MCSF","rs56367447","T","C",-0.497,0.088,{"v":1.72e-08,"d":"1.72E-08"},0.166,0.252,0.511,31.642]
["Macrophage colony-stimulating factor","MCSF","rs62294910","A","G",0.343,0.069,{"v":6.82e-07,"d":"6.82E-07"},0.285,0.186,0.126,24.654]
["Macrophage colony-stimulating factor","MCSF","rs78296352","T","G",0.527,0.111,{"v":1.05e-06,"d":"1.05E-06"},-0.313,0.385,0.416,{"v":22.46,"d":"22.460"}]
["Macrophage colony-stimulating factor","MCSF","rs9387100","C","T",0.135,0.029,{"v":4.07e-06,"d":"4.07E-06"},-0.112,0.091,0.217,21.438]
["Monocyte specific chemokine 3 (CCL7)","MCP3","rs10892381","T","C",0.241,0.048,{"v":3.56e-07,"d":"3.56E-07"},-0.096,0.095,0.313,25.677]
["Monocyte specific chemokine 3 (CCL7)","MCP3","rs62492260","T","G",-0.279,0.058,{"v":1.54e-06,"d":"1.54E-06"},-0.032,0.126,0.797,23.106]
["Monocyte specific chemokine 3 (CCL7)","MCP3","rs73669117","G","A",0.624,0.131,{"v":2.56e-06,"d":"2.56E-06"},0.173,0.297,{"v":0.56,"d":"0.560"},22.675]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs10145849","A","G",-0.076,0.016,{"v":3.41e-06,"d":"3.41E-06"},-0.068,0.093,0.462,{"v":21.72,"d":"21.720"}]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs10744620","C","T",-0.079,0.016,{"v":9.91e-07,"d":"9.91E-07"},0.002,0.093,0.982,23.955]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs111995966","G","T",-0.145,0.031,{"v":2.53e-06,"d":"2.53E-06"},0.393,{"v":0.17,"d":"0.170"},0.021,21.939]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs112313229","A","G",-0.165,0.031,{"v":1.43e-07,"d":"1.43E-07"},0.007,0.175,0.969,27.655]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs12073356","A","G",-0.143,0.031,{"v":4.17e-06,"d":"4.17E-06"},-0.325,0.178,0.067,21.024]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs12075","A","G",0.219,0.016,{"v":1.44e-44,"d":"1.44E-44"},0.021,{"v":0.09,"d":"0.090"},0.815,198.719]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs12493471","C","T",-0.116,0.016,{"v":6.81e-13,"d":"6.81E-13"},-0.116,0.093,0.214,51.538]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs146522229","T","C",-0.598,0.118,{"v":3.56e-07,"d":"3.56E-07"},0.351,{"v":0.68,"d":"0.680"},0.606,25.779]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs2228467","C","T",0.264,0.029,{"v":9.19e-20,"d":"9.19E-20"},-0.357,0.169,0.035,82.117]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs2712431","A","C",-0.079,0.017,{"v":4.75e-06,"d":"4.75E-06"},-0.105,0.099,0.286,20.936]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs56212190","T","C",0.181,0.037,{"v":9.85e-07,"d":"9.85E-07"},-0.237,0.209,0.256,23.547]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs7197349","G","A",-0.097,0.021,{"v":2.62e-06,"d":"2.62E-06"},-0.118,0.113,0.295,22.081]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs7517040","G","A",0.099,0.019,{"v":2.44e-07,"d":"2.44E-07"},0.253,0.108,0.019,26.703]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","rs9317045","C","A",-0.113,0.024,{"v":1.52e-06,"d":"1.52E-06"},0.193,0.126,0.127,23.089]
["Interleukin-12p70","IL-12p70","rs13209117","A","G",{"v":0.1,"d":"0.100"},0.019,{"v":5.57e-08,"d":"5.57E-08"},-0.088,0.103,0.394,29.021]
["Interleukin-12p70","IL-12p70","rs17229494","G","A",0.117,0.026,{"v":4.93e-06,"d":"4.93E-06"},-0.048,0.143,0.737,20.796]
["Interleukin-12p70","IL-12p70","rs282258","C","T",-0.073,0.016,{"v":3.21e-06,"d":"3.21E-06"},-0.102,{"v":0.09,"d":"0.090"},0.261,21.898]
["Interleukin-12p70","IL-12p70","rs41282644","A","G",0.147,{"v":0.03,"d":"0.030"},{"v":1.05e-06,"d":"1.05E-06"},-0.046,0.168,0.784,23.478]
["Interleukin-12p70","IL-12p70","rs4349809","G","T",-0.378,0.016,{"v":2.5600000000000003e-124,"d":"2.56E-124"},0.165,{"v":0.09,"d":"0.090"},0.067,564.287]
["Interleukin-12p70","IL-12p70","rs71361173","G","T",-0.111,0.024,{"v":3.06e-06,"d":"3.06E-06"},-0.203,0.134,0.131,{"v":21.57,"d":"21.570"}]
["Interleukin-12p70","IL-12p70","rs72831623","A","G",0.191,0.037,{"v":2.42e-07,"d":"2.42E-07"},-0.024,0.178,0.893,26.732]
["Interleukin-12p70","IL-12p70","rs782107","A","G",0.075,0.016,{"v":1.6e-06,"d":"1.60E-06"},-0.097,0.089,0.279,23.114]
["Interleukin-12p70","IL-12p70","rs79121401","C","T",-0.555,0.121,{"v":4.24e-06,"d":"4.24E-06"},-0.047,{"v":0.62,"d":"0.620"},{"v":0.94,"d":"0.940"},21.163]
["Interleukin-12p70","IL-12p70","rs9472183","G","A",0.102,0.016,{"v":8.61e-11,"d":"8.61E-11"},0.023,{"v":0.09,"d":"0.090"},0.796,42.126]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs10809307","C","T",-0.131,0.028,{"v":3.64e-06,"d":"3.64E-06"},-0.032,0.108,0.766,21.415]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs113831257","A","G",0.359,0.064,{"v":2.53e-08,"d":"2.53E-08"},-0.184,0.207,0.374,{"v":31.11,"d":"31.110"}]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs11626201","A","C",0.116,0.025,{"v":1.93e-06,"d":"1.93E-06"},0.029,0.093,0.758,22.495]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs143799975","G","A",0.798,0.164,{"v":1e-06,"d":"1.00E-06"},-0.163,0.534,{"v":0.76,"d":"0.760"},23.787]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs34383175","T","C",-0.315,0.066,{"v":1.51e-06,"d":"1.51E-06"},0.168,0.246,0.495,23.031]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs75970138","A","G",-0.485,0.104,{"v":1.53e-06,"d":"1.53E-06"},0.366,0.395,0.355,21.748]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs7645625","G","T",0.109,0.024,{"v":4.41e-06,"d":"4.41E-06"},-0.163,0.091,0.074,20.997]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs79848609","C","A",{"v":-0.26,"d":"-0.260"},0.054,{"v":8.75e-07,"d":"8.75E-07"},0.079,0.206,0.703,23.496]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs8112909","A","G",-0.143,{"v":0.03,"d":"0.030"},{"v":1.94e-06,"d":"1.94E-06"},0.003,0.112,0.976,22.746]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","rs9450351","C","T",0.277,0.049,{"v":1.48e-08,"d":"1.48E-08"},-0.151,0.193,0.433,32.042]
["Interleukin-18","IL-18","rs10414578","T","C",-0.177,0.035,{"v":4.16e-07,"d":"4.16E-07"},0.231,0.131,0.078,25.604]
["Interleukin-18","IL-18","rs115267715","T","C",0.451,{"v":0.08,"d":"0.080"},{"v":1.72e-08,"d":"1.72E-08"},-0.102,0.326,0.755,31.753]
["Interleukin-18","IL-18","rs116383510","C","A",0.543,0.106,{"v":3e-07,"d":"3.00E-07"},-0.358,{"v":0.37,"d":"0.370"},0.333,26.402]
["Interleukin-18","IL-18","rs117266781","T","C",0.684,0.147,{"v":3.15e-06,"d":"3.15E-06"},-0.243,0.473,0.607,21.716]
["Interleukin-18","IL-18","rs144841621","T","C",0.518,0.114,{"v":3.81e-06,"d":"3.81E-06"},-0.399,0.459,0.386,{"v":20.61,"d":"20.610"}]
["Interleukin-18","IL-18","rs17229943","C","A",0.312,0.046,{"v":1.62e-11,"d":"1.62E-11"},-0.203,{"v":0.15,"d":"0.150"},0.175,{"v":45.41,"d":"45.410"}]
["Interleukin-18","IL-18","rs1852105","C","T",-0.304,0.066,{"v":4.32e-06,"d":"4.32E-06"},{"v":-0.38,"d":"-0.380"},0.236,0.107,21.096]
["Interleukin-18","IL-18","rs1979967","T","C",{"v":0.14,"d":"0.140"},0.029,{"v":9.45e-07,"d":"9.45E-07"},-0.073,0.109,0.507,24.031]
["Interleukin-18","IL-18","rs2729385","A","G",0.123,0.026,{"v":3.79e-06,"d":"3.79E-06"},0.188,{"v":0.1,"d":"0.100"},0.061,22.076]
["Interleukin-18","IL-18","rs385076","C","T",0.243,0.025,{"v":1.66e-22,"d":"1.66E-22"},-0.123,0.094,0.188,96.166]
["Interleukin-18","IL-18","rs4482818","G","A",-0.129,0.024,{"v":1.45e-07,"d":"1.45E-07"},{"v":-0.14,"d":"-0.140"},0.091,0.126,27.778]
["Interleukin-18","IL-18","rs658805","A","G",0.123,0.024,{"v":4.94e-07,"d":"4.94E-07"},0.129,0.094,{"v":0.17,"d":"0.170"},25.247]
["Interleukin-18","IL-18","rs71478720","T","C",-0.267,0.028,{"v":3.71e-22,"d":"3.71E-22"},{"v":-0.01,"d":"-0.010"},0.104,0.922,93.515]
["Interleukin-18","IL-18","rs78623212","T","C",0.871,0.178,{"v":6.71e-07,"d":"6.71E-07"},-0.787,0.492,0.109,{"v":23.97,"d":"23.970"}]
["Interleukin-18","IL-18","rs78716465","A","G",0.327,0.068,{"v":1.63e-06,"d":"1.63E-06"},0.274,0.241,0.256,22.919]
["Interleukin-17","IL-17","rs117029961","A","G",0.459,0.102,{"v":4.94e-06,"d":"4.94E-06"},{"v":0.62,"d":"0.620"},0.523,0.235,20.405]
["Interleukin-17","IL-17","rs117556572","T","C",{"v":-0.51,"d":"-0.510"},{"v":0.11,"d":"0.110"},{"v":3.28e-06,"d":"3.28E-06"},-0.366,0.295,0.214,21.552]
["Interleukin-17","IL-17","rs1530455","C","T",-0.108,0.017,{"v":4.87e-10,"d":"4.87E-10"},{"v":0.11,"d":"0.110"},0.094,0.241,38.972]
["Interleukin-17","IL-17","rs17106604","T","C",0.113,0.023,{"v":6.37e-07,"d":"6.37E-07"},-0.165,0.126,0.191,25.178]
["Interleukin-17","IL-17","rs17282552","C","T",{"v":0.2,"d":"0.200"},0.041,{"v":8.21e-07,"d":"8.21E-07"},{"v":0.19,"d":"0.190"},0.208,{"v":0.36,"d":"0.360"},24.411]
["Interleukin-17","IL-17","rs184080173","C","T",-0.238,0.047,{"v":4.19e-07,"d":"4.19E-07"},-0.362,0.252,0.152,{"v":25.62,"d":"25.620"}]
["Interleukin-17","IL-17","rs187475560","T","C",-0.243,0.052,{"v":3.29e-06,"d":"3.29E-06"},-0.155,0.271,0.569,{"v":21.91,"d":"21.910"}]
["Interleukin-17","IL-17","rs62191444","T","G",-0.114,0.025,{"v":4.22e-06,"d":"4.22E-06"},-0.015,0.125,0.904,21.153]
["Interleukin-17","IL-17","rs78296352","T","G",0.303,0.065,{"v":4.27e-06,"d":"4.27E-06"},-0.313,0.385,0.416,21.956]
["Interleukin-17","IL-17","rs78612928","C","T",-0.104,0.022,{"v":2.62e-06,"d":"2.62E-06"},0.152,0.122,0.212,{"v":21.82,"d":"21.820"}]
["Interleukin-13","IL-13","rs117795020","A","G",-0.352,0.072,{"v":9.86e-07,"d":"9.86E-07"},0.056,0.264,0.833,24.197]
["Interleukin-13","IL-13","rs12623722","A","G",-0.119,0.026,{"v":4.19e-06,"d":"4.19E-06"},{"v":-0.03,"d":"-0.030"},0.098,0.763,21.096]
["Interleukin-13","IL-13","rs139083458","T","C",{"v":0.99,"d":"0.990"},0.211,{"v":2.81e-06,"d":"2.81E-06"},0.009,0.719,{"v":0.99,"d":"0.990"},22.086]
["Interleukin-13","IL-13","rs142167313","C","T",0.313,0.062,{"v":3.98e-07,"d":"3.98E-07"},0.012,{"v":0.23,"d":"0.230"},{"v":0.96,"d":"0.960"},25.735]
["Interleukin-13","IL-13","rs27949","T","C",-0.117,0.025,{"v":3.43e-06,"d":"3.43E-06"},-0.079,0.096,0.408,21.482]
["Interleukin-13","IL-13","rs6799107","C","T",0.146,{"v":0.03,"d":"0.030"},{"v":1.25e-06,"d":"1.25E-06"},-0.216,0.114,0.059,23.495]
["Interleukin-13","IL-13","rs7073807","C","T",-0.168,0.036,{"v":2.37e-06,"d":"2.37E-06"},0.129,0.132,0.327,22.323]
["Interleukin-13","IL-13","rs75995699","A","G",0.332,{"v":0.07,"d":"0.070"},{"v":2.64e-06,"d":"2.64E-06"},0.032,0.253,{"v":0.9,"d":"0.900"},{"v":22.61,"d":"22.610"}]
["Interleukin-13","IL-13","rs9472168","G","A",-0.424,0.025,{"v":1.08e-65,"d":"1.08E-65"},0.161,{"v":0.09,"d":"0.090"},0.075,292.851]
["Interleukin-10","IL-10","rs10457128","A","G",-0.087,0.017,{"v":5.24e-07,"d":"5.24E-07"},0.087,0.093,0.348,25.292]
["Interleukin-10","IL-10","rs10493718","A","C",{"v":-0.11,"d":"-0.110"},0.022,{"v":7.16e-07,"d":"7.16E-07"},0.138,0.122,0.256,24.552]
["Interleukin-10","IL-10","rs11206302","T","C",-0.119,0.025,{"v":2.2e-06,"d":"2.20E-06"},0.096,0.138,0.486,{"v":22.44,"d":"22.440"}]
["Interleukin-10","IL-10","rs2086656","T","C",-0.079,0.017,{"v":3.78e-06,"d":"3.78E-06"},0.215,0.094,0.023,21.289]
["Interleukin-10","IL-10","rs282258","C","T",-0.099,0.016,{"v":1e-09,"d":"1.00E-09"},-0.102,{"v":0.09,"d":"0.090"},0.261,37.497]
["Interleukin-10","IL-10","rs3025021","C","T",-0.095,{"v":0.02,"d":"0.020"},{"v":1.46e-06,"d":"1.46E-06"},0.109,0.095,0.251,23.585]
["Interleukin-10","IL-10","rs41282660","G","A",0.119,0.026,{"v":3.72e-06,"d":"3.72E-06"},-0.116,0.132,0.382,21.924]
["Interleukin-10","IL-10","rs4349809","G","T",-0.285,0.017,{"v":5.77e-67,"d":"5.77E-67"},0.165,{"v":0.09,"d":"0.090"},0.067,298.976]
["Interleukin-10","IL-10","rs465757","A","G",0.084,0.017,{"v":1.17e-06,"d":"1.17E-06"},0.075,0.094,0.424,23.306]
["Interleukin-10","IL-10","rs7088799","G","T",0.085,0.017,{"v":3.23e-07,"d":"3.23E-07"},-0.112,0.092,0.223,26.028]
["Interleukin-8 (CXCL8)","IL-8","rs11634944","C","T",0.121,0.025,{"v":1.29e-06,"d":"1.29E-06"},0.077,0.094,0.412,23.208]
["Interleukin-8 (CXCL8)","IL-8","rs12075","A","G",{"v":0.12,"d":"0.120"},0.024,{"v":3.88e-07,"d":"3.88E-07"},0.021,{"v":0.09,"d":"0.090"},0.815,25.855]
["Interleukin-8 (CXCL8)","IL-8","rs141926526","C","A",0.615,0.131,{"v":2.57e-06,"d":"2.57E-06"},-0.037,0.491,{"v":0.94,"d":"0.940"},{"v":22.1,"d":"22.100"}]
["Interleukin-8 (CXCL8)","IL-8","rs2673604","A","C",-0.127,0.026,{"v":7.02e-07,"d":"7.02E-07"},0.146,0.097,0.131,24.648]
["Interleukin-6","IL-6","rs1333040","T","C",0.074,0.016,{"v":3.17e-06,"d":"3.17E-06"},-0.003,0.089,0.971,21.817]
["Interleukin-6","IL-6","rs13412535","A","G",-0.116,0.022,{"v":7.34e-08,"d":"7.34E-08"},-0.135,0.112,0.228,29.311]
["Interleukin-6","IL-6","rs72831623","A","G",0.197,0.037,{"v":1.08e-07,"d":"1.08E-07"},-0.024,0.178,0.893,{"v":28.13,"d":"28.130"}]
["Interleukin-6","IL-6","rs73273528","T","C",0.267,0.055,{"v":9.58e-07,"d":"9.58E-07"},{"v":-0.52,"d":"-0.520"},0.293,0.076,23.347]
["Interleukin-6","IL-6","rs76856708","C","T",-0.329,{"v":0.07,"d":"0.070"},{"v":2.61e-06,"d":"2.61E-06"},-0.317,0.387,0.412,22.077]
["Interleukin-1 receptor antagonist","IL1ra","rs1054402","C","T",-0.131,0.027,{"v":1.13e-06,"d":"1.13E-06"},0.102,0.103,0.325,23.576]
["Interleukin-1 receptor antagonist","IL1ra","rs11627423","C","A",-0.117,0.025,{"v":2.11e-06,"d":"2.11E-06"},-0.161,0.093,0.083,22.476]
["Interleukin-1 receptor antagonist","IL1ra","rs12121840","T","C",0.269,0.057,{"v":2.43e-06,"d":"2.43E-06"},-0.435,0.201,{"v":0.03,"d":"0.030"},22.227]
["Interleukin-1 receptor antagonist","IL1ra","rs56134659","G","A",0.112,0.024,{"v":2.44e-06,"d":"2.44E-06"},0.012,{"v":0.09,"d":"0.090"},0.897,22.213]
["Interleukin-1 receptor antagonist","IL1ra","rs61335305","A","C",0.445,0.091,{"v":1e-06,"d":"1.00E-06"},-0.367,0.335,0.273,24.051]
["Interleukin-1 receptor antagonist","IL1ra","rs9623661","T","C",-0.197,0.043,{"v":3.86e-06,"d":"3.86E-06"},0.117,0.158,{"v":0.46,"d":"0.460"},21.298]
["Interleukin-1-beta","IL-1b","rs143319329","T","C",{"v":0.28,"d":"0.280"},0.072,{"v":2e-06,"d":"2.00E-06"},-0.185,0.534,{"v":0.73,"d":"0.730"},15.347]
["Interleukin-1-beta","IL-1b","rs1942793","T","G",0.072,0.019,{"v":4.98e-06,"d":"4.98E-06"},-0.017,0.089,0.848,14.701]
["Interleukin-1-beta","IL-1b","rs61335305","A","C",0.297,0.072,{"v":1.9e-06,"d":"1.90E-06"},-0.367,0.335,0.273,16.783]
["Interleukin-1-beta","IL-1b","rs62015704","G","A",-0.108,0.028,{"v":2.09e-06,"d":"2.09E-06"},-0.056,0.135,{"v":0.68,"d":"0.680"},14.618]
["Interleukin-1-beta","IL-1b","rs9898641","C","T",0.203,0.045,{"v":3.59e-06,"d":"3.59E-06"},-0.112,0.093,0.229,20.033]
["Hepatocyte growth factor","HGF","rs11060254","A","G",{"v":-0.08,"d":"-0.080"},0.017,{"v":1.58e-06,"d":"1.58E-06"},-0.042,0.096,0.664,22.948]
["Hepatocyte growth factor","HGF","rs150322232","G","A",{"v":-0.21,"d":"-0.210"},0.046,{"v":4.89e-06,"d":"4.89E-06"},0.314,{"v":0.23,"d":"0.230"},0.172,{"v":20.65,"d":"20.650"}]
["Hepatocyte growth factor","HGF","rs1698249","C","A",{"v":0.17,"d":"0.170"},0.037,{"v":4.09e-06,"d":"4.09E-06"},-0.028,0.212,0.895,20.835]
["Hepatocyte growth factor","HGF","rs2003620","T","C",0.228,0.049,{"v":2.83e-06,"d":"2.83E-06"},{"v":0.11,"d":"0.110"},0.264,0.677,21.721]
["Hepatocyte growth factor","HGF","rs3748034","T","G",{"v":0.15,"d":"0.150"},0.023,{"v":1.81e-10,"d":"1.81E-10"},0.013,0.134,{"v":0.92,"d":"0.920"},40.818]
["Hepatocyte growth factor","HGF","rs5745687","T","C",-0.307,0.041,{"v":2.75e-14,"d":"2.75E-14"},0.003,0.225,0.991,57.252]
["Hepatocyte growth factor","HGF","rs62481625","C","T",-0.109,0.023,{"v":1.18e-06,"d":"1.18E-06"},-0.136,0.124,0.273,23.512]
["Interleukin-9","IL-9","rs41294750","T","C",0.351,0.075,{"v":2.36e-06,"d":"2.36E-06"},-0.001,0.264,0.998,{"v":22.07,"d":"22.070"}]
["Interleukin-9","IL-9","rs4880409","T","C",-0.336,0.072,{"v":3.5e-06,"d":"3.50E-06"},-0.051,0.442,0.908,21.533]
["Interleukin-9","IL-9","rs61867538","T","C",0.357,0.077,{"v":3.93e-06,"d":"3.93E-06"},0.153,{"v":0.22,"d":"0.220"},0.488,21.227]
["Interleukin-9","IL-9","rs7232268","G","A",-0.276,0.059,{"v":2.52e-06,"d":"2.52E-06"},{"v":0.28,"d":"0.280"},0.227,0.218,22.092]
["Interleukin-9","IL-9","rs7242404","A","G",-0.123,0.026,{"v":3.27e-06,"d":"3.27E-06"},-0.005,0.099,0.958,21.637]
["Interleukin-9","IL-9","rs76963786","T","C",-0.287,0.056,{"v":4.5e-07,"d":"4.50E-07"},-0.358,0.213,0.093,26.457]
["Interleukin-7","IL-7","rs117509142","C","T",0.327,0.069,{"v":1.99e-06,"d":"1.99E-06"},0.076,0.251,0.763,{"v":22.59,"d":"22.590"}]
["Interleukin-7","IL-7","rs141425475","C","T",0.478,0.102,{"v":2.53e-06,"d":"2.53E-06"},-0.461,0.317,0.146,22.144]
["Interleukin-7","IL-7","rs144701438","A","G",-0.482,0.099,{"v":9.75e-07,"d":"9.75E-07"},0.442,0.373,0.236,23.742]
["Interleukin-7","IL-7","rs17091524","C","T",-0.492,0.101,{"v":1.91e-06,"d":"1.91E-06"},-0.436,0.347,0.209,23.627]
["Interleukin-7","IL-7","rs28793375","T","C",0.164,0.036,{"v":4.46e-06,"d":"4.46E-06"},-0.079,0.132,0.552,20.588]
["Interleukin-7","IL-7","rs4320361","T","G",-0.325,0.025,{"v":6.87e-39,"d":"6.87E-39"},0.164,{"v":0.09,"d":"0.090"},0.069,169.836]
["Interleukin-7","IL-7","rs62006410","T","C",-0.156,{"v":0.03,"d":"0.030"},{"v":3.39e-07,"d":"3.39E-07"},0.046,0.105,0.662,26.405]
["Interleukin-7","IL-7","rs75904417","C","A",{"v":0.17,"d":"0.170"},0.035,{"v":1.16e-06,"d":"1.16E-06"},-0.287,0.127,0.024,23.671]
["Interleukin-7","IL-7","rs77981494","C","T",0.518,0.106,{"v":1.07e-06,"d":"1.07E-06"},0.534,0.315,{"v":0.09,"d":"0.090"},23.683]
["Interleukin-5","IL-5","rs11680908","G","A",-0.263,0.055,{"v":2.03e-06,"d":"2.03E-06"},-0.066,{"v":0.2,"d":"0.200"},0.741,22.605]
["Interleukin-5","IL-5","rs6737109","C","T",-0.116,0.025,{"v":2.4e-06,"d":"2.40E-06"},{"v":0.01,"d":"0.010"},{"v":0.09,"d":"0.090"},0.909,22.056]
["Interleukin-5","IL-5","rs72831687","A","G",-0.524,0.111,{"v":1.69e-06,"d":"1.69E-06"},-0.368,0.356,0.301,22.317]
["Interleukin-5","IL-5","rs73040130","C","T",-0.264,0.053,{"v":6e-07,"d":"6.00E-07"},0.162,0.194,0.403,24.868]
["Interleukin-5","IL-5","rs7767396","G","A",-0.152,0.025,{"v":7.69e-10,"d":"7.69E-10"},0.159,{"v":0.09,"d":"0.090"},0.076,37.928]
["Interleukin-4","IL-4","rs10512267","C","T",0.082,0.016,{"v":2.94e-07,"d":"2.94E-07"},-0.159,0.091,0.079,26.194]
["Interleukin-4","IL-4","rs116705532","G","T",0.468,0.098,{"v":1.76e-06,"d":"1.76E-06"},-0.765,0.529,0.148,22.879]
["Interleukin-4","IL-4","rs117146485","C","T",0.292,0.063,{"v":2.71e-06,"d":"2.71E-06"},-0.022,0.337,0.947,{"v":21.61,"d":"21.610"}]
["Interleukin-4","IL-4","rs17713451","A","G",0.127,0.025,{"v":4.97e-07,"d":"4.97E-07"},0.006,0.142,0.965,25.357]
["Interleukin-4","IL-4","rs73023729","A","G",{"v":-0.18,"d":"-0.180"},0.037,{"v":9.03e-07,"d":"9.03E-07"},0.054,0.218,0.806,{"v":24.08,"d":"24.080"}]
["Interleukin-4","IL-4","rs7613691","G","A",-0.178,0.038,{"v":4.05e-06,"d":"4.05E-06"},-0.184,0.206,{"v":0.37,"d":"0.370"},21.367]
["Interleukin-4","IL-4","rs79597994","T","C",-0.583,0.127,{"v":4.32e-06,"d":"4.32E-06"},-0.201,0.517,0.698,{"v":21.08,"d":"21.080"}]
["Interleukin-4","IL-4","rs9508291","C","T",0.168,0.036,{"v":3.03e-06,"d":"3.03E-06"},-0.156,0.205,0.448,21.795]
["Interleukin-4","IL-4","rs9941733","G","A",-0.114,0.023,{"v":6.88e-07,"d":"6.88E-07"},0.014,0.118,0.906,24.782]
["Interleukin-2 receptor, alpha subunit","IL2ra","rs11241559","G","T",0.126,0.027,{"v":2e-06,"d":"2.00E-06"},0.075,0.103,0.464,{"v":22.58,"d":"22.580"}]
["Interleukin-2 receptor, alpha subunit","IL2ra","rs117244812","A","G",-0.706,0.149,{"v":2.1e-06,"d":"2.10E-06"},-0.792,0.529,0.134,22.537]
["Interleukin-2 receptor, alpha subunit","IL2ra","rs12722497","A","C",0.628,0.049,{"v":1.57e-38,"d":"1.57E-38"},0.091,0.176,0.606,167.609]
["Interleukin-2 receptor, alpha subunit","IL2ra","rs185231391","C","T",{"v":-0.85,"d":"-0.850"},0.181,{"v":1.47e-06,"d":"1.47E-06"},0.215,0.559,{"v":0.7,"d":"0.700"},22.094]
["Interleukin-2 receptor, alpha subunit","IL2ra","rs4733117","C","A",-0.137,0.029,{"v":2.63e-06,"d":"2.63E-06"},0.005,0.111,0.966,21.981]
["Interleukin-2 receptor, alpha subunit","IL2ra","rs61705228","T","C",{"v":0.33,"d":"0.330"},0.072,{"v":3.99e-06,"d":"3.99E-06"},-0.334,0.237,0.158,21.281]
["Interleukin-2","IL-2","rs12051139","C","T",0.113,0.025,{"v":4.76e-06,"d":"4.76E-06"},0.066,0.091,0.468,20.967]
["Interleukin-2","IL-2","rs13412535","A","G",0.176,0.033,{"v":1.18e-07,"d":"1.18E-07"},-0.135,0.112,0.228,28.231]
["Interleukin-2","IL-2","rs170117","T","C",-0.162,0.035,{"v":3.87e-06,"d":"3.87E-06"},0.143,0.127,0.261,21.467]
["Interleukin-2","IL-2","rs2807544","G","A",-0.118,0.025,{"v":3.41e-06,"d":"3.41E-06"},0.047,0.092,0.614,21.569]
["Interleukin-2","IL-2","rs4634519","G","A",0.126,0.027,{"v":2.77e-06,"d":"2.77E-06"},-0.032,{"v":0.1,"d":"0.100"},0.748,21.975]
["Interleukin-2","IL-2","rs61335305","A","C",0.451,0.092,{"v":7.32e-07,"d":"7.32E-07"},-0.367,0.335,0.273,24.179]
["Interleukin-2","IL-2","rs62124990","T","G",-0.696,{"v":0.15,"d":"0.150"},{"v":3.22e-06,"d":"3.22E-06"},-0.322,0.325,0.322,{"v":21.68,"d":"21.680"}]
["Interleukin-2","IL-2","rs7615304","G","A",0.117,0.024,{"v":1.21e-06,"d":"1.21E-06"},{"v":-0.08,"d":"-0.080"},{"v":0.09,"d":"0.090"},0.376,23.454]
["Interleukin-2","IL-2","rs80336398","C","T",{"v":-0.4,"d":"-0.400"},0.086,{"v":2.82e-06,"d":"2.82E-06"},-0.178,0.284,0.531,21.745]
["Interferon-gamma","IFNg","rs10487554","A","G",{"v":-0.09,"d":"-0.090"},0.018,{"v":1.09e-06,"d":"1.09E-06"},0.187,{"v":0.1,"d":"0.100"},0.061,23.919]
["Interferon-gamma","IFNg","rs113600793","A","C",0.183,0.037,{"v":8.95e-07,"d":"8.95E-07"},-0.103,0.192,0.592,24.044]
["Interferon-gamma","IFNg","rs115729819","G","A",-0.248,0.052,{"v":1.38e-06,"d":"1.38E-06"},-0.135,0.283,0.633,23.264]
["Interferon-gamma","IFNg","rs11843756","G","T",-0.184,0.039,{"v":3.09e-06,"d":"3.09E-06"},-0.407,0.221,0.065,21.921]
["Interferon-gamma","IFNg","rs12420286","C","T",-0.238,{"v":0.05,"d":"0.050"},{"v":2.08e-06,"d":"2.08E-06"},0.811,0.273,0.003,22.491]
["Interferon-gamma","IFNg","rs1867282","T","C",0.077,0.017,{"v":3.15e-06,"d":"3.15E-06"},-0.124,0.091,0.172,{"v":21.74,"d":"21.740"}]
["Interferon-gamma","IFNg","rs2073438","A","G",{"v":0.09,"d":"0.090"},0.019,{"v":1.68e-06,"d":"1.68E-06"},-0.104,0.102,0.305,22.816]
["Interferon-gamma","IFNg","rs74148555","T","C",-0.373,0.077,{"v":2.63e-06,"d":"2.63E-06"},-0.382,0.314,0.224,23.249]
["Interferon-gamma","IFNg","rs78296352","T","G",0.343,0.065,{"v":1.38e-07,"d":"1.38E-07"},-0.313,0.385,0.416,27.675]
["Growth regulated oncogene-α (CXCL1)","GROa","rs1113500","T","G",0.117,0.024,{"v":1.57e-06,"d":"1.57E-06"},-0.105,0.091,0.246,{"v":23.15,"d":"23.150"}]
["Growth regulated oncogene-α (CXCL1)","GROa","rs118158560","A","G",{"v":0.27,"d":"0.270"},0.059,{"v":3.42e-06,"d":"3.42E-06"},0.381,0.209,0.068,20.707]
["Growth regulated oncogene-α (CXCL1)","GROa","rs12075","A","G",0.375,0.024,{"v":1.24e-55,"d":"1.24E-55"},0.021,{"v":0.09,"d":"0.090"},0.815,250.494]
["Growth regulated oncogene-α (CXCL1)","GROa","rs140734053","A","G",0.726,0.156,{"v":3.58e-06,"d":"3.58E-06"},-0.086,0.467,0.855,21.613]
["Growth regulated oncogene-α (CXCL1)","GROa","rs185768063","G","A",{"v":-0.4,"d":"-0.400"},0.076,{"v":1.46e-07,"d":"1.46E-07"},-0.034,{"v":0.28,"d":"0.280"},0.902,27.673]
["Growth regulated oncogene-α (CXCL1)","GROa","rs188345231","T","C",0.623,0.132,{"v":4.34e-06,"d":"4.34E-06"},-0.397,0.499,0.426,22.175]
["Growth regulated oncogene-α (CXCL1)","GROa","rs2422841","A","G",-0.166,0.036,{"v":4.66e-06,"d":"4.66E-06"},-0.097,{"v":0.13,"d":"0.130"},0.458,21.068]
["Growth regulated oncogene-α (CXCL1)","GROa","rs508977","G","T",{"v":0.38,"d":"0.380"},0.028,{"v":7.56e-42,"d":"7.56E-42"},0.084,0.105,0.419,184.378]
["Growth regulated oncogene-α (CXCL1)","GROa","rs62024303","G","A",0.305,0.067,{"v":4.41e-06,"d":"4.41E-06"},{"v":0.06,"d":"0.060"},0.221,0.785,21.014]
["Growth regulated oncogene-α (CXCL1)","GROa","rs78653452","T","G",-0.736,0.156,{"v":1.21e-06,"d":"1.21E-06"},0.818,0.467,{"v":0.08,"d":"0.080"},22.328]
["Granulocyte colony-stimulating factor","GCSF","rs115256310","G","A",0.682,0.136,{"v":6.73e-07,"d":"6.73E-07"},0.069,0.524,0.895,25.155]
["Granulocyte colony-stimulating factor","GCSF","rs11903143","G","A",-0.087,0.018,{"v":6.35e-07,"d":"6.35E-07"},0.102,0.099,0.301,24.435]
["Granulocyte colony-stimulating factor","GCSF","rs147128865","T","C",{"v":0.27,"d":"0.270"},0.059,{"v":4.92e-06,"d":"4.92E-06"},{"v":-0.22,"d":"-0.220"},{"v":0.31,"d":"0.310"},0.477,21.157]
["Granulocyte colony-stimulating factor","GCSF","rs1817411","T","C",0.089,0.019,{"v":3.1e-06,"d":"3.10E-06"},0.066,0.109,0.541,21.713]
["Granulocyte colony-stimulating factor","GCSF","rs2671444","A","G",-0.078,0.017,{"v":2.48e-06,"d":"2.48E-06"},0.034,0.093,0.713,22.306]
["Granulocyte colony-stimulating factor","GCSF","rs74148555","T","C",-0.372,0.076,{"v":1.55e-06,"d":"1.55E-06"},-0.382,0.314,0.224,24.212]
["Granulocyte colony-stimulating factor","GCSF","rs76287671","T","C",0.094,0.019,{"v":6.92e-07,"d":"6.92E-07"},0.008,0.105,0.943,24.631]
["Granulocyte colony-stimulating factor","GCSF","rs77318030","C","T",0.205,0.043,{"v":2.21e-06,"d":"2.21E-06"},-0.141,0.224,0.529,{"v":22.83,"d":"22.830"}]
["Basic fibroblast growth factor","bFGF","rs13412535","A","G",-0.111,0.023,{"v":7.34e-07,"d":"7.34E-07"},-0.135,0.112,0.228,24.426]
["Basic fibroblast growth factor","bFGF","rs145577605","A","G",0.208,0.043,{"v":9.64e-07,"d":"9.64E-07"},0.288,0.246,0.242,{"v":23.64,"d":"23.640"}]
["Basic fibroblast growth factor","bFGF","rs747334","G","A",-0.075,0.016,{"v":4.53e-06,"d":"4.53E-06"},0.029,{"v":0.09,"d":"0.090"},0.743,{"v":20.97,"d":"20.970"}]
["Basic fibroblast growth factor","bFGF","rs75168112","C","T",{"v":0.1,"d":"0.100"},0.021,{"v":3e-06,"d":"3.00E-06"},-0.064,0.114,0.578,{"v":21.88,"d":"21.880"}]
["Basic fibroblast growth factor","bFGF","rs9907295","T","C",-0.132,0.027,{"v":7.95e-07,"d":"7.95E-07"},-0.134,0.146,0.359,24.043]
["Eotaxin (CCL11)","Eotaxin","rs11087905","A","C",0.094,0.019,{"v":5.48e-07,"d":"5.48E-07"},-0.061,0.095,0.525,24.789]
["Eotaxin (CCL11)","Eotaxin","rs112347425","T","C",0.158,0.028,{"v":8.65e-09,"d":"8.65E-09"},0.192,0.156,0.219,32.535]
["Eotaxin (CCL11)","Eotaxin","rs12075","A","G",0.167,0.016,{"v":1.33e-26,"d":"1.33E-26"},0.021,{"v":0.09,"d":"0.090"},0.815,114.737]
["Eotaxin (CCL11)","Eotaxin","rs1476670","C","A",0.101,0.022,{"v":3.51e-06,"d":"3.51E-06"},-0.129,{"v":0.12,"d":"0.120"},0.283,21.535]
["Eotaxin (CCL11)","Eotaxin","rs2024050","G","A",-0.173,{"v":0.03,"d":"0.030"},{"v":1.1e-08,"d":"1.10E-08"},-0.282,0.174,0.105,32.524]
["Eotaxin (CCL11)","Eotaxin","rs2210755","C","T",{"v":0.11,"d":"0.110"},0.024,{"v":4.85e-06,"d":"4.85E-06"},-0.291,0.129,0.024,20.812]
["Eotaxin (CCL11)","Eotaxin","rs2211994","C","T",-0.089,0.018,{"v":6.08e-07,"d":"6.08E-07"},-0.131,{"v":0.1,"d":"0.100"},{"v":0.19,"d":"0.190"},{"v":25,"d":"25.000"}]
["Eotaxin (CCL11)","Eotaxin","rs2228467","C","T",0.416,0.029,{"v":2.2699999999999997e-46,"d":"2.27E-46"},-0.357,0.169,0.035,203.258]
["Eotaxin (CCL11)","Eotaxin","rs2419841","C","T",0.128,0.028,{"v":4.98e-06,"d":"4.98E-06"},0.092,0.163,0.574,20.949]
["Eotaxin (CCL11)","Eotaxin","rs5746492","G","A",-0.095,0.021,{"v":3.96e-06,"d":"3.96E-06"},-0.017,{"v":0.12,"d":"0.120"},0.891,{"v":21.24,"d":"21.240"}]
["Eotaxin (CCL11)","Eotaxin","rs5754733","A","C",-0.104,0.021,{"v":1.06e-06,"d":"1.06E-06"},0.002,0.118,0.988,23.709]
["Eotaxin (CCL11)","Eotaxin","rs59808887","T","C",-0.167,0.036,{"v":2.91e-06,"d":"2.91E-06"},-0.014,{"v":0.18,"d":"0.180"},{"v":0.94,"d":"0.940"},21.839]
["Eotaxin (CCL11)","Eotaxin","rs75426604","A","C",-0.137,0.029,{"v":2.53e-06,"d":"2.53E-06"},0.242,0.154,0.116,22.035]
["Eotaxin (CCL11)","Eotaxin","rs79722574","T","C",-0.111,0.023,{"v":1.06e-06,"d":"1.06E-06"},0.195,0.129,0.133,{"v":23.83,"d":"23.830"}]
["Eotaxin (CCL11)","Eotaxin","rs80341932","G","A",-0.102,0.021,{"v":6.69e-07,"d":"6.69E-07"},0.022,0.108,0.838,24.563]
["Eotaxin (CCL11)","Eotaxin","rs9317045","C","A",-0.118,0.024,{"v":5.82e-07,"d":"5.82E-07"},0.193,0.126,0.127,24.874]
["MR, Mendelian randomization;POI, primary ovarian insufficiency; SNP, single nucleotide polymorphism; SE, standard error."]

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["Table S2 Full result of MR estimates  (Systemic inflammatory regulators on POI)."]
["Systemic inflammatory regulators (exposure)","Abbreviation","MR method","No. of SNP","OR(95%CI)","P-value"]
["Cutaneous T-cell attracting (CCL27)","CTACK","Inverse variance weighted",9,"0.92(0.61-1.38)",0.68]
["Cutaneous T-cell attracting (CCL27)","CTACK","cML-MA-BIC",9,"0.93(0.61-1.43)",0.75]
["Cutaneous T-cell attracting (CCL27)","CTACK","Maximum likelihood",9,"0.92(0.61-1.39)",0.69]
["Cutaneous T-cell attracting (CCL27)","CTACK","MR Egger",9,"1.18(0.52-2.69)",0.7]
["Cutaneous T-cell attracting (CCL27)","CTACK","Weighted median",9,"1.11(0.64-1.92)",0.71]
["Beta nerve growth factor","bNGF","Inverse variance weighted",7,"1.42(0.82-2.46)",0.21]
["Beta nerve growth factor","bNGF","cML-MA-BIC",7,"1.42(0.81-2.50)",0.22]
["Beta nerve growth factor","bNGF","Maximum likelihood",7,"1.43(0.82-2.51)",0.21]
["Beta nerve growth factor","bNGF","MR Egger",7,"3.74(0.25-55.69)",0.38]
["Beta nerve growth factor","bNGF","Weighted median",7,"1.44(0.71-2.92)",0.31]
["Vascular endothelial growth factor","VEGF","Inverse variance weighted",10,"0.73(0.54-0.99)",{"v":0.046,"d":"4.60E-02"}]
["Vascular endothelial growth factor","VEGF","cML-MA-BIC",10,"0.73(0.53-1.00)",{"v":0.048,"d":"4.80E-02"}]
["Vascular endothelial growth factor","VEGF","Maximum likelihood",10,"0.73(0.53-0.99)",{"v":0.046,"d":"4.60E-02"}]
["Vascular endothelial growth factor","VEGF","MR Egger",10,"0.78(0.46-1.31)",0.38]
["Vascular endothelial growth factor","VEGF","Weighted median",10,"0.73(0.52-1.03)",0.07]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","Inverse variance weighted",6,"1.19(0.60-2.36)",0.62]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","cML-MA-BIC",6,"1.23(0.66-2.26)",0.51]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","Maximum likelihood",6,"1.20(0.66-2.17)",0.55]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","MR Egger",6,"1.83(0.56-5.99)",0.37]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","Weighted median",6,"1.24(0.57-2.72)",0.59]
["TNF-related apoptosis inducing ligand","TRAIL","Inverse variance weighted",15,"1.06(0.79-1.43)",0.7]
["TNF-related apoptosis inducing ligand","TRAIL","cML-MA-BIC",15,"1.07(0.79-1.46)",0.66]
["TNF-related apoptosis inducing ligand","TRAIL","Maximum likelihood",15,"1.06(0.79-1.44)",0.69]
["TNF-related apoptosis inducing ligand","TRAIL","MR Egger",15,"0.99(0.68-1.43)",0.94]
["TNF-related apoptosis inducing ligand","TRAIL","Weighted median",15,"1.04(0.70-1.55)",0.84]
["Tumor necrosis factor-beta","TNFb","Inverse variance weighted",4,"1.25(0.61-2.55)",0.54]
["Tumor necrosis factor-beta","TNFb","cML-MA-BIC",4,"1.11(0.65-1.89)",0.7]
["Tumor necrosis factor-beta","TNFb","Maximum likelihood",4,"1.27(0.82-1.97)",0.29]
["Tumor necrosis factor-beta","TNFb","MR Egger",4,"0.65(0.28-1.50)",0.42]
["Tumor necrosis factor-beta","TNFb","Weighted median",4,"1.12(0.65-1.92)",0.68]
["Tumor necrosis factor-alpha","TNFa","Inverse variance weighted",5,"1.08(0.57-2.03)",0.82]
["Tumor necrosis factor-alpha","TNFa","cML-MA-BIC",5,"1.08(0.57-2.05)",0.82]
["Tumor necrosis factor-alpha","TNFa","Maximum likelihood",5,"1.08(0.57-2.04)",0.82]
["Tumor necrosis factor-alpha","TNFa","MR Egger",5,"1.05(0.36-3.05)",0.94]
["Tumor necrosis factor-alpha","TNFa","Weighted median",5,"1.03(0.46-2.28)",0.94]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","Inverse variance weighted",9,"2.01(0.89-4.55)",0.09]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","cML-MA-BIC",9,"2.05(0.88-4.76)",0.1]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","Maximum likelihood",9,"2.07(0.89-4.78)",0.09]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","MR Egger",9,"1.27(0.22-7.33)",0.8]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","Weighted median",9,"1.44(0.47-4.36)",0.52]
["Stem cell growth factor beta","SCGFb","Inverse variance weighted",14,"0.88(0.63-1.21)",0.42]
["Stem cell growth factor beta","SCGFb","cML-MA-BIC",14,"0.87(0.63-1.21)",0.41]
["Stem cell growth factor beta","SCGFb","Maximum likelihood",14,"0.87(0.63-1.21)",0.42]
["Stem cell growth factor beta","SCGFb","MR Egger",14,"0.87(0.48-1.58)",0.66]
["Stem cell growth factor beta","SCGFb","Weighted median",14,"0.86(0.56-1.32)",0.48]
["Stem cell factor","SCF","Inverse variance weighted",9,"0.78(0.30-2.06)",0.62]
["Stem cell factor","SCF","cML-MA-BIC",9,"0.94(0.41-2.12)",0.87]
["Stem cell factor","SCF","Maximum likelihood",9,"0.78(0.38-1.59)",0.49]
["Stem cell factor","SCF","MR Egger",9,"0.16(0.02-1.40)",0.14]
["Stem cell factor","SCF","Weighted median",9,"0.86(0.33-2.23)",0.76]
["Interleukin-16","IL-16","Inverse variance weighted",10,"0.98(0.64-1.51)",0.94]
["Interleukin-16","IL-16","cML-MA-BIC",10,"0.95(0.65-1.39)",0.79]
["Interleukin-16","IL-16","Maximum likelihood",10,"0.99(0.68-1.42)",0.94]
["Interleukin-16","IL-16","MR Egger",10,"1.00(0.46-2.21)",1]
["Interleukin-16","IL-16","Weighted median",10,"0.90(0.56-1.47)",0.68]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","Inverse variance weighted",9,"1.60(0.82-3.12)",0.17]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","cML-MA-BIC",9,"1.56(0.90-2.70)",0.11]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","Maximum likelihood",9,"1.63(0.98-2.71)",0.06]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","MR Egger",9,"0.59(0.11-3.11)",0.55]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","Weighted median",9,"1.39(0.68-2.83)",0.36]
["Platelet derived growth factor BB","PDGFbb","Inverse variance weighted",13,"0.92(0.60-1.41)",0.71]
["Platelet derived growth factor BB","PDGFbb","cML-MA-BIC",13,"0.91(0.59-1.41)",0.68]
["Platelet derived growth factor BB","PDGFbb","Maximum likelihood",13,"0.92(0.60-1.42)",0.71]
["Platelet derived growth factor BB","PDGFbb","MR Egger",13,"0.64(0.28-1.48)",0.32]
["Platelet derived growth factor BB","PDGFbb","Weighted median",13,"0.71(0.39-1.29)",0.27]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","Inverse variance weighted",17,"0.83(0.63-1.10)",0.2]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","cML-MA-BIC",17,"0.83(0.64-1.06)",0.13]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","Maximum likelihood",17,"0.83(0.65-1.07)",0.14]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","MR Egger",17,"0.68(0.45-1.03)",0.09]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","Weighted median",17,"0.82(0.60-1.13)",0.22]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","Inverse variance weighted",7,"0.81(0.40-1.61)",0.54]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","cML-MA-BIC",7,"0.83(0.44-1.55)",0.55]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","Maximum likelihood",7,"0.80(0.44-1.44)",0.45]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","MR Egger",7,"0.18(0.04-0.84)",0.08]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","Weighted median",7,"0.92(0.40-2.12)",0.85]
["Monokine induced by interferon-gamma (CXCL9)","MIG","Inverse variance weighted",14,"0.81(0.53-1.24)",0.33]
["Monokine induced by interferon-gamma (CXCL9)","MIG","cML-MA-BIC",14,"0.85(0.56-1.30)",0.45]
["Monokine induced by interferon-gamma (CXCL9)","MIG","Maximum likelihood",14,"0.80(0.54-1.18)",0.26]
["Monokine induced by interferon-gamma (CXCL9)","MIG","MR Egger",14,"0.47(0.19-1.19)",0.14]
["Monokine induced by interferon-gamma (CXCL9)","MIG","Weighted median",14,"0.89(0.52-1.52)",0.68]
["Macrophage colony-stimulating factor","MCSF","Inverse variance weighted",8,"0.93(0.61-1.43)",0.75]
["Macrophage colony-stimulating factor","MCSF","cML-MA-BIC",8,"0.92(0.61-1.37)",0.67]
["Macrophage colony-stimulating factor","MCSF","Maximum likelihood",8,"0.93(0.63-1.37)",0.71]
["Macrophage colony-stimulating factor","MCSF","MR Egger",8,"1.03(0.46-2.30)",0.94]
["Macrophage colony-stimulating factor","MCSF","Weighted median",8,"0.95(0.56-1.60)",0.84]
["Monocyte specific chemokine 3 (CCL7)","MCP3","Inverse variance weighted",3,"0.95(0.58-1.56)",0.85]
["Monocyte specific chemokine 3 (CCL7)","MCP3","cML-MA-BIC",3,"0.97(0.58-1.62)",0.9]
["Monocyte specific chemokine 3 (CCL7)","MCP3","Maximum likelihood",3,"0.95(0.58-1.57)",0.85]
["Monocyte specific chemokine 3 (CCL7)","MCP3","MR Egger",3,"2.03(0.41-10.07)",0.54]
["Monocyte specific chemokine 3 (CCL7)","MCP3","Weighted median",3,"1.03(0.57-1.86)",0.92]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","Inverse variance weighted",14,"1.00(0.52-1.94)",1]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","cML-MA-BIC",14,"0.99(0.60-1.63)",0.97]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","Maximum likelihood",14,"1.00(0.62-1.60)",1]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","MR Egger",14,"0.30(0.07-1.28)",0.13]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","Weighted median",14,"1.06(0.54-2.09)",0.86]
["Interleukin-12p70","IL-12p70","Inverse variance weighted",10,"0.74(0.50-1.09)",0.13]
["Interleukin-12p70","IL-12p70","cML-MA-BIC",10,"0.74(0.50-1.09)",0.13]
["Interleukin-12p70","IL-12p70","Maximum likelihood",10,"0.74(0.50-1.09)",0.13]
["Interleukin-12p70","IL-12p70","MR Egger",10,"0.58(0.30-1.12)",0.15]
["Interleukin-12p70","IL-12p70","Weighted median",10,"0.65(0.42-1.00)",0.05]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","Inverse variance weighted",10,"0.68(0.43-1.07)",0.1]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","cML-MA-BIC",10,"0.68(0.42-1.08)",0.1]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","Maximum likelihood",10,"0.68(0.43-1.08)",0.1]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","MR Egger",10,"0.63(0.25-1.55)",0.34]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","Weighted median",10,"0.66(0.37-1.20)",0.17]
["Interleukin-18","IL-18","Inverse variance weighted",15,"0.87(0.59-1.28)",0.47]
["Interleukin-18","IL-18","cML-MA-BIC",15,"0.85(0.62-1.17)",0.33]
["Interleukin-18","IL-18","Maximum likelihood",15,"0.86(0.63-1.18)",0.35]
["Interleukin-18","IL-18","MR Egger",15,"0.41(0.19-0.86)",{"v":0.034,"d":"3.40E-02"}]
["Interleukin-18","IL-18","Weighted median",15,"0.66(0.42-1.02)",0.06]
["Interleukin-17","IL-17","Inverse variance weighted",10,"1.19(0.61-2.31)",0.62]
["Interleukin-17","IL-17","cML-MA-BIC",10,"1.20(0.65-2.21)",0.56]
["Interleukin-17","IL-17","Maximum likelihood",10,"1.20(0.65-2.21)",0.56]
["Interleukin-17","IL-17","MR Egger",10,"4.27(1.32-13.75)",{"v":0.041,"d":"4.10E-02"}]
["Interleukin-17","IL-17","Weighted median",10,"1.93(0.82-4.57)",0.13]
["Interleukin-13","IL-13","Inverse variance weighted",9,"0.74(0.53-1.03)",0.07]
["Interleukin-13","IL-13","cML-MA-BIC",9,"0.74(0.53-1.03)",0.08]
["Interleukin-13","IL-13","Maximum likelihood",9,"0.74(0.53-1.03)",0.07]
["Interleukin-13","IL-13","MR Egger",9,"0.69(0.37-1.30)",0.29]
["Interleukin-13","IL-13","Weighted median",9,"0.73(0.50-1.07)",0.11]
["Interleukin-10","IL-10","Inverse variance weighted",10,"0.53(0.33-0.85)",{"v":0.0091,"d":"9.10E-03"}]
["Interleukin-10","IL-10","cML-MA-BIC",10,"0.52(0.32-0.84)",{"v":0.0071,"d":"7.10E-03"}]
["Interleukin-10","IL-10","Maximum likelihood",10,"0.53(0.33-0.84)",{"v":0.0074,"d":"7.40E-03"}]
["Interleukin-10","IL-10","MR Egger",10,"0.63(0.22-1.78)",0.41]
["Interleukin-10","IL-10","Weighted median",10,"0.52(0.30-0.91)",{"v":0.023,"d":"2.30E-02"}]
["Interleukin-8 (CXCL8)","IL-8","Inverse variance weighted",4,"0.90(0.42-1.92)",0.79]
["Interleukin-8 (CXCL8)","IL-8","cML-MA-BIC",4,"0.92(0.42-2.01)",0.83]
["Interleukin-8 (CXCL8)","IL-8","Maximum likelihood",4,"0.90(0.42-1.93)",0.78]
["Interleukin-8 (CXCL8)","IL-8","MR Egger",4,"0.88(0.08-9.50)",0.92]
["Interleukin-8 (CXCL8)","IL-8","Weighted median",4,"1.07(0.42-2.70)",0.89]
["Interleukin-6","IL-6","Inverse variance weighted",5,"1.03(0.36-2.98)",0.95]
["Interleukin-6","IL-6","cML-MA-BIC",5,"1.07(0.41-2.83)",0.89]
["Interleukin-6","IL-6","Maximum likelihood",5,"1.04(0.40-2.65)",0.94]
["Interleukin-6","IL-6","MR Egger",5,"0.60(0.05-7.33)",0.71]
["Interleukin-6","IL-6","Weighted median",5,"0.95(0.27-3.33)",0.93]
["Interleukin-1 receptor antagonist","IL1ra","Inverse variance weighted",6,"0.66(0.29-1.49)",0.31]
["Interleukin-1 receptor antagonist","IL1ra","cML-MA-BIC",6,"0.58(0.28-1.20)",0.14]
["Interleukin-1 receptor antagonist","IL1ra","Maximum likelihood",6,"0.65(0.34-1.24)",0.19]
["Interleukin-1 receptor antagonist","IL1ra","MR Egger",6,"0.14(0.03-0.73)",0.08]
["Interleukin-1 receptor antagonist","IL1ra","Weighted median",6,"0.50(0.21-1.17)",0.11]
["Interleukin-1-beta","IL-1b","Inverse variance weighted",5,"0.60(0.29-1.26)",0.18]
["Interleukin-1-beta","IL-1b","cML-MA-BIC",5,"0.60(0.28-1.27)",0.18]
["Interleukin-1-beta","IL-1b","Maximum likelihood",5,"0.60(0.28-1.27)",0.18]
["Interleukin-1-beta","IL-1b","MR Egger",5,"0.36(0.07-1.89)",0.31]
["Interleukin-1-beta","IL-1b","Weighted median",5,"0.59(0.24-1.46)",0.25]
["Hepatocyte growth factor","HGF","Inverse variance weighted",7,"1.06(0.50-2.26)",0.87]
["Hepatocyte growth factor","HGF","cML-MA-BIC",7,"1.07(0.50-2.31)",0.86]
["Hepatocyte growth factor","HGF","Maximum likelihood",7,"1.07(0.50-2.28)",0.87]
["Hepatocyte growth factor","HGF","MR Egger",7,"0.52(0.09-3.05)",0.5]
["Hepatocyte growth factor","HGF","Weighted median",7,"1.06(0.43-2.62)",0.91]
["Interleukin-9","IL-9","Inverse variance weighted",6,"1.23(0.66-2.30)",0.51]
["Interleukin-9","IL-9","cML-MA-BIC",6,"1.26(0.66-2.40)",0.49]
["Interleukin-9","IL-9","Maximum likelihood",6,"1.24(0.66-2.34)",0.51]
["Interleukin-9","IL-9","MR Egger",6,"1.48(0.32-6.78)",0.64]
["Interleukin-9","IL-9","Weighted median",6,"1.14(0.47-2.73)",0.78]
["Interleukin-7","IL-7","Inverse variance weighted",9,"0.71(0.44-1.15)",0.17]
["Interleukin-7","IL-7","cML-MA-BIC",9,"0.68(0.45-1.01)",0.06]
["Interleukin-7","IL-7","Maximum likelihood",9,"0.70(0.48-1.02)",0.07]
["Interleukin-7","IL-7","MR Egger",9,"1.36(0.42-4.44)",0.62]
["Interleukin-7","IL-7","Weighted median",9,"0.61(0.37-1.00)",{"v":0.049,"d":"4.90E-02"}]
["Interleukin-5","IL-5","Inverse variance weighted",5,"0.80(0.42-1.53)",0.5]
["Interleukin-5","IL-5","cML-MA-BIC",5,"0.81(0.42-1.54)",0.52]
["Interleukin-5","IL-5","Maximum likelihood",5,"0.79(0.42-1.48)",0.46]
["Interleukin-5","IL-5","MR Egger",5,"1.84(0.43-7.81)",0.47]
["Interleukin-5","IL-5","Weighted median",5,"0.83(0.36-1.89)",0.66]
["Interleukin-4","IL-4","Inverse variance weighted",9,"0.70(0.34-1.44)",0.34]
["Interleukin-4","IL-4","cML-MA-BIC",9,"0.70(0.34-1.47)",0.35]
["Interleukin-4","IL-4","Maximum likelihood",9,"0.70(0.34-1.46)",0.35]
["Interleukin-4","IL-4","MR Egger",9,"1.22(0.29-5.16)",0.8]
["Interleukin-4","IL-4","Weighted median",9,"0.90(0.34-2.37)",0.84]
["Interleukin-2 receptor, alpha subunit","IL2ra","Inverse variance weighted",6,"1.10(0.72-1.68)",0.65]
["Interleukin-2 receptor, alpha subunit","IL2ra","cML-MA-BIC",6,"1.11(0.72-1.71)",0.63]
["Interleukin-2 receptor, alpha subunit","IL2ra","Maximum likelihood",6,"1.11(0.72-1.69)",0.64]
["Interleukin-2 receptor, alpha subunit","IL2ra","MR Egger",6,"1.09(0.53-2.25)",0.83]
["Interleukin-2 receptor, alpha subunit","IL2ra","Weighted median",6,"1.12(0.67-1.86)",0.66]
["Interleukin-2","IL-2","Inverse variance weighted",9,"0.85(0.54-1.33)",0.48]
["Interleukin-2","IL-2","cML-MA-BIC",9,"0.83(0.52-1.34)",0.45]
["Interleukin-2","IL-2","Maximum likelihood",9,"0.85(0.53-1.35)",0.48]
["Interleukin-2","IL-2","MR Egger",9,"1.24(0.52-3.00)",0.64]
["Interleukin-2","IL-2","Weighted median",9,"0.74(0.40-1.38)",0.34]
["Interferon-gamma","IFNg","Inverse variance weighted",9,"0.58(0.19-1.73)",0.33]
["Interferon-gamma","IFNg","cML-MA-BIC",9,"0.58(0.25-1.36)",0.21]
["Interferon-gamma","IFNg","Maximum likelihood",9,"0.55(0.26-1.18)",0.13]
["Interferon-gamma","IFNg","MR Egger",9,"1.87(0.23-14.85)",0.57]
["Interferon-gamma","IFNg","Weighted median",9,"0.49(0.17-1.39)",0.18]
["Growth regulated oncogene-α (CXCL1)","GROa","Inverse variance weighted",10,"1.05(0.78-1.42)",0.75]
["Growth regulated oncogene-α (CXCL1)","GROa","cML-MA-BIC",10,"1.06(0.79-1.42)",0.71]
["Growth regulated oncogene-α (CXCL1)","GROa","Maximum likelihood",10,"1.05(0.79-1.41)",0.74]
["Growth regulated oncogene-α (CXCL1)","GROa","MR Egger",10,"1.00(0.48-2.08)",1]
["Growth regulated oncogene-α (CXCL1)","GROa","Weighted median",10,"1.08(0.75-1.54)",0.68]
["Granulocyte colony-stimulating factor","GCSF","Inverse variance weighted",8,"0.97(0.48-1.97)",0.93]
["Granulocyte colony-stimulating factor","GCSF","cML-MA-BIC",8,"0.96(0.47-1.98)",0.91]
["Granulocyte colony-stimulating factor","GCSF","Maximum likelihood",8,"0.97(0.47-1.98)",0.93]
["Granulocyte colony-stimulating factor","GCSF","MR Egger",8,"1.34(0.39-4.55)",0.66]
["Granulocyte colony-stimulating factor","GCSF","Weighted median",8,"1.09(0.44-2.72)",0.85]
["Basic fibroblast growth factor","bFGF","Inverse variance weighted",5,"1.76(0.66-4.69)",0.26]
["Basic fibroblast growth factor","bFGF","cML-MA-BIC",5,"1.80(0.66-4.90)",0.25]
["Basic fibroblast growth factor","bFGF","Maximum likelihood",5,"1.78(0.66-4.84)",0.26]
["Basic fibroblast growth factor","bFGF","MR Egger",5,"15.18(0.49-471.67)",0.22]
["Basic fibroblast growth factor","bFGF","Weighted median",5,"2.80(0.78-9.99)",0.11]
["Eotaxin (CCL11)","Eotaxin","Inverse variance weighted",16,"0.69(0.41-1.15)",0.15]
["Eotaxin (CCL11)","Eotaxin","cML-MA-BIC",16,"0.67(0.43-1.04)",0.08]
["Eotaxin (CCL11)","Eotaxin","Maximum likelihood",16,"0.68(0.44-1.05)",0.08]
["Eotaxin (CCL11)","Eotaxin","MR Egger",16,"0.55(0.16-1.90)",0.36]
["Eotaxin (CCL11)","Eotaxin","Weighted median",16,"0.59(0.31-1.11)",0.1]
["MR, Mendelian randomization; POI, primary ovarian insufficiency;  SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; IVW, inverse variance weighted; ML, maximum likelihood."]

{"sheet":"sheet3","index":2,"n_rows":44,"n_cols":6,"rows_kept":44,"merged":[[0,0,0,5],[43,0,43,5]],"flags":["formulas_cached_only"]}
["Table S3 The heterogeneity of Systemic inflammatory regulators instrumental variables (Systemic inflammatory regulators on POI)."]
["Systemic inflammatory regulators (exposure)","Abbreviation","Cochran's Q","df","P-value","I2(%)"]
["Cutaneous T-cell attracting (CCL27)","CTACK",7.91,8,0.442,{"v":0,"d":"0.00"}]
["Beta nerve growth factor","bNGF",4.29,6,0.638,{"v":0,"d":"0.00"}]
["Vascular endothelial growth factor","VEGF",8.18,9,0.516,{"v":0,"d":"0.00"}]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF",7.01,5,{"v":0.22,"d":"0.220"},28.63]
["TNF-related apoptosis inducing ligand","TRAIL",10.04,14,{"v":0.76,"d":"0.760"},{"v":0,"d":"0.00"}]
["Tumor necrosis factor-beta","TNFb",8.42,3,0.038,64.35]
["Tumor necrosis factor-alpha","TNFa",1.43,4,0.839,{"v":0,"d":"0.00"}]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a",4.83,8,0.776,{"v":0,"d":"0.00"}]
["Stem cell growth factor beta","SCGFb",6.02,13,0.946,{"v":0,"d":"0.00"}]
["Stem cell factor","SCF",15.65,8,0.048,48.89]
["Interleukin-16","IL-16",12.71,9,0.176,{"v":29.2,"d":"29.20"}]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES",15.07,8,0.058,46.91]
["Platelet derived growth factor BB","PDGFbb",12.03,12,0.443,0.28]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b",20.76,16,0.188,22.95]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a",8.81,6,0.185,31.87]
["Monokine induced by interferon-gamma (CXCL9)","MIG",{"v":16.1,"d":"16.10"},13,0.244,19.24]
["Macrophage colony-stimulating factor","MCSF",8.97,7,0.255,21.95]
["Monocyte specific chemokine 3 (CCL7)","MCP3",1.39,2,{"v":0.5,"d":"0.500"},{"v":0,"d":"0.00"}]
["Monocyte chemotactic protein-1 (CCL2)","MCP1",26.89,13,0.013,51.65]
["Interleukin-12p70","IL-12p70",6.81,9,0.657,{"v":0,"d":"0.00"}]
["Interferon gamma-induced protein 10 (CXCL10)","IP10",3.61,9,0.935,{"v":0,"d":"0.00"}]
["Interleukin-18","IL-18",22.53,14,0.068,37.86]
["Interleukin-17","IL-17",11.18,9,0.263,19.53]
["Interleukin-13","IL-13",5.32,8,0.723,{"v":0,"d":"0.00"}]
["Interleukin-10","IL-10",9.51,9,0.392,5.33]
["Interleukin-8 (CXCL8)","IL-8",2.94,3,0.401,{"v":0,"d":"0.00"}]
["Interleukin-6","IL-6",5.28,4,0.259,24.28]
["Interleukin-1 receptor antagonist","IL1ra",8.66,5,0.123,42.28]
["Interleukin-1-beta","IL-1b",1.15,4,0.886,{"v":0,"d":"0.00"}]
["Hepatocyte growth factor","HGF",3.43,6,0.753,{"v":0,"d":"0.00"}]
["Interleukin-9","IL-9",4.42,5,0.491,{"v":0,"d":"0.00"}]
["Interleukin-7","IL-7",13.75,8,0.089,41.81]
["Interleukin-5","IL-5",4.51,4,0.342,11.22]
["Interleukin-4","IL-4",5.88,8,0.661,{"v":0,"d":"0.00"}]
["Interleukin-2 receptor, alpha subunit","IL2ra",4.98,5,0.419,{"v":0,"d":"0.00"}]
["Interleukin-2","IL-2",6.46,8,0.596,{"v":0,"d":"0.00"}]
["Interferon-gamma","IFNg",19.04,8,0.015,57.98]
["Growth regulated oncogene-α (CXCL1)","GROa",9.65,9,0.379,6.74]
["Granulocyte colony-stimulating factor","GCSF",3.98,7,0.783,{"v":0,"d":"0.00"}]
["Basic fibroblast growth factor","bFGF",2.81,4,0.591,{"v":0,"d":"0.00"}]
["Eotaxin (CCL11)","Eotaxin",21.49,15,0.122,30.21]
["Df, degree of freedom; POI, primary ovarian insufficiency."]

{"sheet":"sheet4","index":3,"n_rows":44,"n_cols":5,"rows_kept":44,"merged":[[0,0,0,4],[43,0,43,4]],"flags":["formulas_cached_only"]}
["Table S4 Directional horizontal pleiotropy assessed by intercept term in MR Egger regression (Systemic inflammatory regulators on POI)."]
["Systemic inflammatory regulators (exposure)","Abbreviation","Egger_intercept","SE","P-value"]
["Cutaneous T-cell attracting (CCL27)","CTACK",-0.073,0.105,0.507]
["Beta nerve growth factor","bNGF",-0.146,0.203,0.505]
["Vascular endothelial growth factor","VEGF",{"v":-0.02,"d":"-0.020"},0.064,0.759]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF",-0.142,{"v":0.16,"d":"0.160"},0.426]
["TNF-related apoptosis inducing ligand","TRAIL",0.034,0.052,{"v":0.53,"d":"0.530"}]
["Tumor necrosis factor-beta","TNFb",0.234,{"v":0.12,"d":"0.120"},0.191]
["Tumor necrosis factor-alpha","TNFa",0.007,0.112,0.957]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a",0.051,0.087,0.577]
["Stem cell growth factor beta","SCGFb",0.001,0.068,0.988]
["Stem cell factor","SCF",{"v":0.21,"d":"0.210"},0.134,{"v":0.16,"d":"0.160"}]
["Interleukin-16","IL-16",-0.006,0.103,0.959]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES",0.233,0.182,0.242]
["Platelet derived growth factor BB","PDGFbb",0.063,0.064,0.345]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b",0.081,0.063,0.219]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a",0.282,0.138,0.096]
["Monokine induced by interferon-gamma (CXCL9)","MIG",0.137,0.108,0.227]
["Macrophage colony-stimulating factor","MCSF",-0.041,0.141,0.779]
["Monocyte specific chemokine 3 (CCL7)","MCP3",-0.233,0.238,0.508]
["Monocyte chemotactic protein-1 (CCL2)","MCP1",0.181,0.101,0.098]
["Interleukin-12p70","IL-12p70",0.054,0.061,0.399]
["Interferon gamma-induced protein 10 (CXCL10)","IP10",0.017,0.088,0.848]
["Interleukin-18","IL-18",0.192,0.086,0.043]
["Interleukin-17","IL-17",-0.249,{"v":0.1,"d":"0.100"},0.037]
["Interleukin-13","IL-13",0.021,0.084,0.812]
["Interleukin-10","IL-10",-0.026,0.071,0.729]
["Interleukin-8 (CXCL8)","IL-8",0.004,0.169,0.983]
["Interleukin-6","IL-6",0.083,0.171,0.661]
["Interleukin-1 receptor antagonist","IL1ra",{"v":0.26,"d":"0.260"},0.131,0.117]
["Interleukin-1-beta","IL-1b",0.089,0.129,0.541]
["Hepatocyte growth factor","HGF",0.118,0.135,0.421]
["Interleukin-9","IL-9",-0.047,{"v":0.18,"d":"0.180"},0.808]
["Interleukin-7","IL-7",-0.193,0.165,{"v":0.28,"d":"0.280"}]
["Interleukin-5","IL-5",-0.169,0.135,{"v":0.3,"d":"0.300"}]
["Interleukin-4","IL-4",-0.095,0.111,0.421]
["Interleukin-2 receptor, alpha subunit","IL2ra",0.006,0.113,0.963]
["Interleukin-2","IL-2",-0.077,0.078,0.356]
["Interferon-gamma","IFNg",-0.186,0.145,0.241]
["Growth regulated oncogene-α (CXCL1)","GROa",0.018,0.118,0.885]
["Granulocyte colony-stimulating factor","GCSF",-0.052,0.083,0.552]
["Basic fibroblast growth factor","bFGF",-0.242,0.189,{"v":0.29,"d":"0.290"}]
["Eotaxin (CCL11)","Eotaxin",0.035,{"v":0.09,"d":"0.090"},0.702]
["MR, Mendelian randomization; POI, primary ovarian insufficiency; SE, standard error."]

{"sheet":"sheet5","index":4,"n_rows":45,"n_cols":12,"rows_kept":45,"merged":[[0,0,0,9],[19,3,19,9],[44,0,44,9]],"flags":["formulas_cached_only"]}
["Table S5 MR-PRESSO analysis (Systemic inflammatory regulators on POI)."]
["Systemic inflammatory regulators (exposure)","Abbreviation","MR Analysis","Causal Estimate","SD","T","P-value","RSSobs","Global test P-value","Remove SNP",null,"Outlier-corrected MR-PRESSO"]
["Cutaneous T-cell attracting (CCL27)","CTACK","MR-PRESSO",-0.087,0.207,-0.419,0.686,10.595,0.457,0]
["Beta nerve growth factor","bNGF","MR-PRESSO",{"v":0.35,"d":"0.350"},0.238,1.472,0.192,5.657,0.664,0]
["Vascular endothelial growth factor","VEGF","MR-PRESSO",-0.314,{"v":0.15,"d":"0.150"},-2.091,0.066,8.788,0.688,0]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","MR-PRESSO",0.174,0.349,0.497,{"v":0.64,"d":"0.640"},10.047,0.235,0]
["TNF-related apoptosis inducing ligand","TRAIL","MR-PRESSO",{"v":0.06,"d":"0.060"},0.129,0.463,0.651,11.385,0.779,0]
["Tumor necrosis factor-beta","TNFb","MR-PRESSO",0.224,0.364,0.615,0.582,17.221,0.152,0]
["Tumor necrosis factor-alpha","TNFa","MR-PRESSO",0.073,0.193,0.375,0.727,2.225,0.836,0]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","MR-PRESSO",{"v":0.7,"d":"0.700"},0.323,2.167,0.062,{"v":6.09,"d":"6.090"},{"v":0.79,"d":"0.790"},0]
["Stem cell growth factor beta","SCGFb","MR-PRESSO",-0.133,0.113,-1.176,0.261,7.055,0.958,0]
["Stem cell factor","SCF","MR-PRESSO",-0.248,0.495,-0.501,{"v":0.63,"d":"0.630"},19.291,0.054,0]
["Interleukin-16","IL-16","MR-PRESSO",-0.015,0.217,{"v":-0.07,"d":"-0.070"},0.946,14.654,0.254,0]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","MR-PRESSO",0.469,0.341,1.374,0.207,19.017,0.073,0]
["Platelet derived growth factor BB","PDGFbb","MR-PRESSO",{"v":-0.08,"d":"-0.080"},0.218,-0.368,0.719,15.597,0.421,0]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","MR-PRESSO",-0.185,0.144,{"v":-1.28,"d":"-1.280"},0.219,22.498,0.256,0]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","MR-PRESSO",-0.217,0.354,-0.612,0.563,12.246,0.196,0]
["Monokine induced by interferon-gamma (CXCL9)","MIG","MR-PRESSO",-0.213,0.217,-0.982,0.344,{"v":18.7,"d":"18.700"},0.255,0]
["Macrophage colony-stimulating factor","MCSF","MR-PRESSO",-0.068,0.217,-0.314,0.762,12.281,0.257,0]
["Monocyte specific chemokine 3 (CCL7)","MCP3","MR-PRESSO","Not enough instrumental variables"]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","MR-PRESSO",-0.001,0.338,-0.003,0.998,30.573,0.011,1]
["Interleukin-12p70","IL-12p70","MR-PRESSO",-0.299,0.173,-1.733,0.117,10.484,0.641,0]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","MR-PRESSO",-0.388,0.149,-2.611,0.028,4.301,0.953,0]
["Interleukin-18","IL-18","MR-PRESSO",-0.143,{"v":0.2,"d":"0.200"},-0.717,0.485,25.314,0.076,0]
["Interleukin-17","IL-17","MR-PRESSO",{"v":0.17,"d":"0.170"},0.341,0.499,{"v":0.63,"d":"0.630"},13.981,0.293,0]
["Interleukin-13","IL-13","MR-PRESSO",{"v":-0.3,"d":"-0.300"},0.137,-2.197,0.059,6.641,0.756,0]
["Interleukin-10","IL-10","MR-PRESSO",-0.634,0.243,-2.609,0.028,10.707,{"v":0.52,"d":"0.520"},0]
["Interleukin-8 (CXCL8)","IL-8","MR-PRESSO",-0.104,0.381,-0.273,0.803,5.272,0.459,0]
["Interleukin-6","IL-6","MR-PRESSO",0.034,{"v":0.54,"d":"0.540"},0.063,0.953,8.173,0.309,0]
["Interleukin-1 receptor antagonist","IL1ra","MR-PRESSO",-0.423,0.419,-1.009,0.359,12.519,0.152,0]
["Interleukin-1-beta","IL-1b","MR-PRESSO",-0.506,0.201,{"v":-2.52,"d":"-2.520"},0.065,1.486,0.924,0]
["Hepatocyte growth factor","HGF","MR-PRESSO",0.063,{"v":0.29,"d":"0.290"},0.215,0.837,4.429,0.784,0]
["Interleukin-9","IL-9","MR-PRESSO",0.208,{"v":0.3,"d":"0.300"},0.694,0.519,6.432,0.477,0]
["Interleukin-7","IL-7","MR-PRESSO",-0.337,0.244,-1.381,0.205,16.909,0.141,0]
["Interleukin-5","IL-5","MR-PRESSO",-0.226,0.331,-0.682,0.533,7.745,0.365,0]
["Interleukin-4","IL-4","MR-PRESSO",-0.351,0.314,-1.119,0.296,{"v":7.47,"d":"7.470"},0.672,0]
["Interleukin-2 receptor, alpha subunit","IL2ra","MR-PRESSO",0.098,0.214,0.459,0.665,6.084,0.535,0]
["Interleukin-2","IL-2","MR-PRESSO",-0.163,0.206,-0.791,0.452,8.877,0.559,0]
["Interferon-gamma","IFNg","MR-PRESSO",-0.545,0.558,-0.978,0.357,24.317,0.018,1]
["Interferon-gamma","IFNg","Outlier-corrected MR-PRESSO",{"v":-0.23,"d":"-0.230"},0.502,-0.459,{"v":0.66,"d":"0.660"},15.971,0.106,0]
["Growth regulated oncogene-α (CXCL1)","GROa","MR-PRESSO",0.048,0.152,0.317,0.759,10.882,0.483,0]
["Granulocyte colony-stimulating factor","GCSF","MR-PRESSO",-0.032,0.273,-0.117,{"v":0.91,"d":"0.910"},5.332,{"v":0.79,"d":"0.790"},0]
["Basic fibroblast growth factor","bFGF","MR-PRESSO",0.565,0.419,1.348,0.249,4.345,0.635,0]
["Eotaxin (CCL11)","Eotaxin","MR-PRESSO",-0.377,0.262,-1.442,{"v":0.17,"d":"0.170"},24.893,0.121,0]
["MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; POI, primary ovarian insufficiency; SD, standard deviation; RSSobs, observed residual sum of squares; SNP, single nucleotide polymorphism."]

{"sheet":"sheet6","index":5,"n_rows":44,"n_cols":6,"rows_kept":44,"merged":[[0,0,0,5],[43,0,43,5]],"flags":["formulas_cached_only"]}
["Table S6 MR steiger test (Systemic inflammatory regulators on POI)."]
["Systemic inflammatory regulators (exposure)","Abbreviation","snp_r2.exposure","snp_r2.outcome","correct_causal_direction","steiger_pval"]
["Cutaneous T-cell attracting (CCL27)","CTACK",{"v":0.0909,"d":"9.09E-02"},{"v":4.44e-05,"d":"4.44E-05"},true,{"v":9.62e-74,"d":"9.62E-74"}]
["Beta nerve growth factor","bNGF",{"v":0.048,"d":"4.80E-02"},{"v":3.2e-05,"d":"3.20E-05"},true,{"v":2.51e-37,"d":"2.51E-37"}]
["Vascular endothelial growth factor","VEGF",{"v":0.142,"d":"1.42E-01"},{"v":6.67e-05,"d":"6.67E-05"},true,{"v":7.660000000000001e-226,"d":"7.66E-226"}]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF",{"v":0.0415,"d":"4.15E-02"},{"v":4.03e-05,"d":"4.03E-05"},true,{"v":1e-31,"d":"1.00E-31"}]
["TNF-related apoptosis inducing ligand","TRAIL",{"v":0.156,"d":"1.56E-01"},{"v":5.59e-05,"d":"5.59E-05"},true,{"v":8.87e-288,"d":"8.87E-288"}]
["Tumor necrosis factor-beta","TNFb",{"v":0.0983,"d":"9.83E-02"},{"v":5.21e-05,"d":"5.21E-05"},true,{"v":1.23e-35,"d":"1.23E-35"}]
["Tumor necrosis factor-alpha","TNFa",{"v":0.0335,"d":"3.35E-02"},{"v":8.13e-06,"d":"8.13E-06"},true,{"v":2.98e-26,"d":"2.98E-26"}]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a",{"v":0.0327,"d":"3.27E-02"},{"v":4.2e-05,"d":"4.20E-05"},true,{"v":3.98e-41,"d":"3.98E-41"}]
["Stem cell growth factor beta","SCGFb",{"v":0.132,"d":"1.32E-01"},{"v":3.65e-05,"d":"3.65E-05"},true,{"v":2.81e-112,"d":"2.81E-112"}]
["Stem cell factor","SCF",{"v":0.0303,"d":"3.03E-02"},{"v":8.86e-05,"d":"8.86E-05"},true,{"v":9.33e-50,"d":"9.33E-50"}]
["Interleukin-16","IL-16",{"v":0.107,"d":"1.07E-01"},{"v":6.98e-05,"d":"6.98E-05"},true,{"v":3.19e-83,"d":"3.19E-83"}]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES",{"v":0.0632,"d":"6.32E-02"},{"v":0.000102,"d":"1.02E-04"},true,{"v":2.22e-46,"d":"2.22E-46"}]
["Platelet derived growth factor BB","PDGFbb",{"v":0.0749,"d":"7.49E-02"},{"v":6.68e-05,"d":"6.68E-05"},true,{"v":3.58e-130,"d":"3.58E-130"}]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b",{"v":0.228,"d":"2.28E-01"},{"v":0.000126,"d":"1.26E-04"},true,{"v":0,"d":"0.00E+00"}]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a",{"v":0.044,"d":"4.40E-02"},{"v":5.13e-05,"d":"5.13E-05"},true,{"v":1.27e-33,"d":"1.27E-33"}]
["Monokine induced by interferon-gamma (CXCL9)","MIG",{"v":0.0947,"d":"9.47E-02"},{"v":9.49e-05,"d":"9.49E-05"},true,{"v":1.2899999999999999e-76,"d":"1.29E-76"}]
["Macrophage colony-stimulating factor","MCSF",{"v":0.224,"d":"2.24E-01"},{"v":4.99e-05,"d":"4.99E-05"},true,{"v":2.0399999999999998e-48,"d":"2.04E-48"}]
["Monocyte specific chemokine 3 (CCL7)","MCP3",{"v":0.0835,"d":"8.35E-02"},{"v":7.81e-06,"d":"7.81E-06"},true,{"v":1.63e-17,"d":"1.63E-17"}]
["Monocyte chemotactic protein-1 (CCL2)","MCP1",{"v":0.0707,"d":"7.07E-02"},{"v":0.000148,"d":"1.48E-04"},true,{"v":6.349999999999999e-119,"d":"6.35E-119"}]
["Interleukin-12p70","IL-12p70",{"v":0.0936,"d":"9.36E-02"},{"v":4.99e-05,"d":"4.99E-05"},true,{"v":3e-166,"d":"3.00E-166"}]
["Interferon gamma-induced protein 10 (CXCL10)","IP10",{"v":0.0664,"d":"6.64E-02"},{"v":3.48e-05,"d":"3.48E-05"},true,{"v":4.6e-54,"d":"4.60E-54"}]
["Interleukin-18","IL-18",{"v":0.144,"d":"1.44E-01"},{"v":0.000128,"d":"1.28E-04"},true,{"v":4.97e-119,"d":"4.97E-119"}]
["Interleukin-17","IL-17",{"v":0.0311,"d":"3.11E-02"},{"v":6.31e-05,"d":"6.31E-05"},true,{"v":6.7e-49,"d":"6.70E-49"}]
["Interleukin-13","IL-13",{"v":0.13,"d":"1.30E-01"},{"v":4.68e-05,"d":"4.68E-05"},true,{"v":2.25e-106,"d":"2.25E-106"}]
["Interleukin-10","IL-10",{"v":0.0675,"d":"6.75E-02"},{"v":9.16e-05,"d":"9.16E-05"},true,{"v":3.31e-107,"d":"3.31E-107"}]
["Interleukin-8 (CXCL8)","IL-8",{"v":0.0271,"d":"2.71E-02"},{"v":1.65e-05,"d":"1.65E-05"},true,{"v":1.5300000000000002e-21,"d":"1.53E-21"}]
["Interleukin-6","IL-6",{"v":0.0152,"d":"1.52E-02"},{"v":2.9e-05,"d":"2.90E-05"},true,{"v":7.93e-26,"d":"7.93E-26"}]
["Interleukin-1 receptor antagonist","IL1ra",{"v":0.0373,"d":"3.73E-02"},{"v":5.72e-05,"d":"5.72E-05"},true,{"v":3.34e-29,"d":"3.34E-29"}]
["Interleukin-1-beta","IL-1b",{"v":0.0332,"d":"3.32E-02"},{"v":1.63e-05,"d":"1.63E-05"},true,{"v":9.71e-25,"d":"9.71E-25"}]
["Hepatocyte growth factor","HGF",{"v":0.0252,"d":"2.52E-02"},{"v":1.9e-05,"d":"1.90E-05"},true,{"v":1.05e-43,"d":"1.05E-43"}]
["Interleukin-9","IL-9",{"v":0.0369,"d":"3.69E-02"},{"v":2.66e-05,"d":"2.66E-05"},true,{"v":1.38e-29,"d":"1.38E-29"}]
["Interleukin-7","IL-7",{"v":0.103,"d":"1.03E-01"},{"v":9.34e-05,"d":"9.34E-05"},true,{"v":6.04e-78,"d":"6.04E-78"}]
["Interleukin-5","IL-5",{"v":0.0387,"d":"3.87E-02"},{"v":2.76e-05,"d":"2.76E-05"},true,{"v":7.840000000000001e-29,"d":"7.84E-29"}]
["Interleukin-4","IL-4",{"v":0.0257,"d":"2.57E-02"},{"v":3.73e-05,"d":"3.73E-05"},true,{"v":6.6e-43,"d":"6.60E-43"}]
["Interleukin-2 receptor, alpha subunit","IL2ra",{"v":0.0751,"d":"7.51E-02"},{"v":2.85e-05,"d":"2.85E-05"},true,{"v":1.4099999999999999e-61,"d":"1.41E-61"}]
["Interleukin-2","IL-2",{"v":0.059,"d":"5.90E-02"},{"v":3.82e-05,"d":"3.82E-05"},true,{"v":3.47e-45,"d":"3.47E-45"}]
["Interferon-gamma","IFNg",{"v":0.0272,"d":"2.72E-02"},{"v":0.000117,"d":"1.17E-04"},true,{"v":7.56e-41,"d":"7.56E-41"}]
["Growth regulated oncogene-α (CXCL1)","GROa",{"v":0.171,"d":"1.71E-01"},{"v":5.36e-05,"d":"5.36E-05"},true,{"v":2.34e-141,"d":"2.34E-141"}]
["Granulocyte colony-stimulating factor","GCSF",{"v":0.0233,"d":"2.33E-02"},{"v":2.19e-05,"d":"2.19E-05"},true,{"v":1.54e-38,"d":"1.54E-38"}]
["Basic fibroblast growth factor","bFGF",{"v":0.0153,"d":"1.53E-02"},{"v":2.24e-05,"d":"2.24E-05"},true,{"v":2.34e-24,"d":"2.34E-24"}]
["Eotaxin (CCL11)","Eotaxin",{"v":0.0805,"d":"8.05E-02"},{"v":0.000134,"d":"1.34E-04"},true,{"v":3.69e-135,"d":"3.69E-135"}]
["MR, Mendelian randomization;POI, primary ovarian insufficiency."]

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["Table S7 Summary Results of MR (target Systemic inflammatory regulators on POI). "]
["Systemic inflammatory regulators (exposure)","Abbreviation","MR method","No. of SNP","OR(95%CI)","P-value","Cochran's Q","df","P-value","I2(%)","Egger_intercept","SE","P-value","MR Analysis","Causal Estimate","SD","T","P-value","RSSobs","Global test P-value","Remove SNP","snp_r2.exposure","snp_r2.outcome","correct_causal_direction","steiger_pval"]
["Vascular endothelial growth factor","VEGF","Inverse variance weighted",10,"0.73(0.54-0.99)",{"v":0.046,"d":"4.60E-02"},8.18,9,0.516,{"v":0,"d":"0.00"},{"v":-0.02,"d":"-0.020"},0.064,0.759,"MR-PRESSO",-0.314,{"v":0.15,"d":"0.150"},-2.091,0.066,8.788,0.688,0,{"v":0.142,"d":"1.42E-01"},{"v":6.67e-05,"d":"6.67E-05"},true,{"v":7.660000000000001e-226,"d":"7.66E-226"}]
["Vascular endothelial growth factor","VEGF","cML-MA-BIC",10,"0.73(0.53-1.00)",{"v":0.048,"d":"4.80E-02"}]
["Vascular endothelial growth factor","VEGF","Maximum likelihood",10,"0.73(0.53-0.99)",{"v":0.046,"d":"4.60E-02"}]
["Vascular endothelial growth factor","VEGF","MR Egger",10,"0.78(0.46-1.31)",0.38]
["Vascular endothelial growth factor","VEGF","Weighted median",10,"0.73(0.52-1.03)",0.07]
["Interleukin-10","IL-10","Inverse variance weighted",10,"0.53(0.33-0.85)",{"v":0.0091,"d":"9.10E-03"},9.51,9,0.392,5.33,-0.026,0.071,0.729,"MR-PRESSO",-0.634,0.243,-2.609,0.028,10.707,{"v":0.52,"d":"0.520"},0,{"v":0.0675,"d":"6.75E-02"},{"v":9.16e-05,"d":"9.16E-05"},true,{"v":3.31e-107,"d":"3.31E-107"}]
["Interleukin-10","IL-10","cML-MA-BIC",10,"0.52(0.32-0.84)",{"v":0.0071,"d":"7.10E-03"}]
["Interleukin-10","IL-10","Maximum likelihood",10,"0.53(0.33-0.84)",{"v":0.0074,"d":"7.40E-03"}]
["Interleukin-10","IL-10","MR Egger",10,"0.63(0.22-1.78)",0.41]
["Interleukin-10","IL-10","Weighted median",10,"0.52(0.30-0.91)",{"v":0.023,"d":"2.30E-02"}]
["MR, Mendelian randomization; PRESSO, pleiotropy residual sum and outlier; POI, primary ovarian insufficiency; SNP, single nucleotide polymorphism; SE, standard error; Df, degree of freedom; SD, standard deviation; RSSobs, observed residual sum of squares."]

{"sheet":"sheet8","index":7,"n_rows":387,"n_cols":13,"rows_kept":387,"merged":[[0,0,0,10],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,2,4],[1,5,1,7],[1,8,1,10],[1,11,2,11],[1,12,2,12],[386,0,386,11]],"flags":["formulas_cached_only"]}
["Table S8 Instrumental variables used in MR analysis (POI on Systemic inflammatory regulators)."]
["Systemic inflammatory regulators (Outcome)","Abbreviation","SNP","Effect allele","Other allele","Exposure (POI)",null,null,"Outcome (Systemic inflammatory regulators) ",null,null,"R2","F"]
[{"$nulls":5},"Beta","SE","P-value","Beta","SE","P-value"]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},0.039,0.089,0.563,{"v":0.000194,"d":"1.94E-04"},22.18]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},0.001,0.032,0.985,{"v":0.000211,"d":"2.11E-04"},24.13]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.028,0.029,0.321,{"v":0.000211,"d":"2.11E-04"},24.03]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.029,0.043,0.493,{"v":0.000183,"d":"1.83E-04"},20.84]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.026,0.029,0.406,{"v":0.000228,"d":"2.28E-04"},26.02]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},-0.007,0.041,0.873,{"v":0.000184,"d":"1.84E-04"},21.03]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.028,0.029,0.339,{"v":0.000196,"d":"1.96E-04"},22.34]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},{"v":-0.08,"d":"-0.080"},0.063,0.197,{"v":0.000183,"d":"1.83E-04"},20.87]
["Cutaneous T-cell attracting (CCL27)","CTACK","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.046,0.026,0.077,{"v":0.000198,"d":"1.98E-04"},22.63]
["Beta nerve growth factor","bNGF","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},-0.037,0.093,0.668,{"v":0.000194,"d":"1.94E-04"},22.18]
["Beta nerve growth factor","bNGF","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},{"v":-0.01,"d":"-0.010"},0.032,0.663,{"v":0.000211,"d":"2.11E-04"},24.13]
["Beta nerve growth factor","bNGF","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.036,0.029,0.215,{"v":0.000211,"d":"2.11E-04"},24.03]
["Beta nerve growth factor","bNGF","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.033,0.044,0.461,{"v":0.000183,"d":"1.83E-04"},20.84]
["Beta nerve growth factor","bNGF","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.001,{"v":0.03,"d":"0.030"},0.997,{"v":0.000228,"d":"2.28E-04"},26.02]
["Beta nerve growth factor","bNGF","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.029,0.042,0.481,{"v":0.000184,"d":"1.84E-04"},21.03]
["Beta nerve growth factor","bNGF","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.038,{"v":0.03,"d":"0.030"},0.207,{"v":0.000196,"d":"1.96E-04"},22.34]
["Beta nerve growth factor","bNGF","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},0.025,0.064,0.762,{"v":0.000183,"d":"1.83E-04"},20.87]
["Beta nerve growth factor","bNGF","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.034,0.026,0.201,{"v":0.000198,"d":"1.98E-04"},22.63]
["Vascular endothelial growth factor","VEGF","rs116005451","A","G",2.371,0.513,{"v":3.85e-06,"d":"3.85E-06"},0.007,0.113,0.947,{"v":0.000187,"d":"1.87E-04"},21.33]
["Vascular endothelial growth factor","VEGF","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},-0.038,0.066,0.539,{"v":0.000194,"d":"1.94E-04"},22.18]
["Vascular endothelial growth factor","VEGF","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},{"v":0.01,"d":"0.010"},0.023,0.723,{"v":0.000211,"d":"2.11E-04"},24.13]
["Vascular endothelial growth factor","VEGF","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.015,0.021,0.469,{"v":0.000211,"d":"2.11E-04"},24.03]
["Vascular endothelial growth factor","VEGF","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.105,0.031,{"v":0.000862,"d":"8.62E-04"},{"v":0.000183,"d":"1.83E-04"},20.84]
["Vascular endothelial growth factor","VEGF","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},-0.011,0.022,0.607,{"v":0.000228,"d":"2.28E-04"},26.02]
["Vascular endothelial growth factor","VEGF","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.026,{"v":0.03,"d":"0.030"},0.373,{"v":0.000184,"d":"1.84E-04"},21.03]
["Vascular endothelial growth factor","VEGF","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},0.005,0.021,0.823,{"v":0.000196,"d":"1.96E-04"},22.34]
["Vascular endothelial growth factor","VEGF","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},0.032,0.044,0.481,{"v":0.000183,"d":"1.83E-04"},20.87]
["Vascular endothelial growth factor","VEGF","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.002,0.019,0.929,{"v":0.000198,"d":"1.98E-04"},22.63]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},0.012,0.091,{"v":0.89,"d":"0.890"},{"v":0.000194,"d":"1.94E-04"},22.18]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},{"v":0.01,"d":"0.010"},0.032,0.798,{"v":0.000211,"d":"2.11E-04"},24.13]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},-0.002,0.029,0.941,{"v":0.000211,"d":"2.11E-04"},24.03]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.039,0.043,0.358,{"v":0.000183,"d":"1.83E-04"},20.84]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.061,{"v":0.03,"d":"0.030"},0.041,{"v":0.000228,"d":"2.28E-04"},26.02]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.014,0.042,0.734,{"v":0.000184,"d":"1.84E-04"},21.03]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.028,{"v":0.03,"d":"0.030"},0.339,{"v":0.000196,"d":"1.96E-04"},22.34]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},-0.085,0.064,{"v":0.16,"d":"0.160"},{"v":0.000183,"d":"1.83E-04"},20.87]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.005,0.026,0.865,{"v":0.000198,"d":"1.98E-04"},22.63]
["TNF-related apoptosis inducing ligand","TRAIL","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},-0.018,0.061,0.754,{"v":0.000194,"d":"1.94E-04"},22.18]
["TNF-related apoptosis inducing ligand","TRAIL","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},0.013,0.022,0.575,{"v":0.000211,"d":"2.11E-04"},24.13]
["TNF-related apoptosis inducing ligand","TRAIL","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},-0.007,0.019,0.714,{"v":0.000211,"d":"2.11E-04"},24.03]
["TNF-related apoptosis inducing ligand","TRAIL","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.002,0.029,0.942,{"v":0.000183,"d":"1.83E-04"},20.84]
["TNF-related apoptosis inducing ligand","TRAIL","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.033,{"v":0.02,"d":"0.020"},0.093,{"v":0.000228,"d":"2.28E-04"},26.02]
["TNF-related apoptosis inducing ligand","TRAIL","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.008,0.028,0.787,{"v":0.000184,"d":"1.84E-04"},21.03]
["TNF-related apoptosis inducing ligand","TRAIL","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.007,{"v":0.02,"d":"0.020"},0.717,{"v":0.000196,"d":"1.96E-04"},22.34]
["TNF-related apoptosis inducing ligand","TRAIL","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},{"v":-0.02,"d":"-0.020"},0.041,0.622,{"v":0.000183,"d":"1.83E-04"},20.87]
["TNF-related apoptosis inducing ligand","TRAIL","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.016,0.017,0.343,{"v":0.000198,"d":"1.98E-04"},22.63]
["Tumor necrosis factor-beta","TNFb","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},-0.091,{"v":0.05,"d":"0.050"},0.056,{"v":0.000211,"d":"2.11E-04"},24.13]
["Tumor necrosis factor-beta","TNFb","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.009,0.044,0.838,{"v":0.000211,"d":"2.11E-04"},24.03]
["Tumor necrosis factor-beta","TNFb","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},-0.058,0.066,0.385,{"v":0.000183,"d":"1.83E-04"},20.84]
["Tumor necrosis factor-beta","TNFb","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.067,0.046,0.145,{"v":0.000228,"d":"2.28E-04"},26.02]
["Tumor necrosis factor-beta","TNFb","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},-0.013,0.063,0.808,{"v":0.000184,"d":"1.84E-04"},21.03]
["Tumor necrosis factor-beta","TNFb","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.057,0.045,0.207,{"v":0.000196,"d":"1.96E-04"},22.34]
["Tumor necrosis factor-beta","TNFb","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.117,{"v":0.04,"d":"0.040"},0.003,{"v":0.000198,"d":"1.98E-04"},22.63]
["Tumor necrosis factor-alpha","TNFa","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},{"v":0.02,"d":"0.020"},{"v":0.09,"d":"0.090"},0.817,{"v":0.000194,"d":"1.94E-04"},22.18]
["Tumor necrosis factor-alpha","TNFa","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},-0.006,0.033,0.811,{"v":0.000211,"d":"2.11E-04"},24.13]
["Tumor necrosis factor-alpha","TNFa","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.003,{"v":0.03,"d":"0.030"},0.939,{"v":0.000211,"d":"2.11E-04"},24.03]
["Tumor necrosis factor-alpha","TNFa","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},{"v":0.04,"d":"0.040"},0.044,0.363,{"v":0.000183,"d":"1.83E-04"},20.84]
["Tumor necrosis factor-alpha","TNFa","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.017,{"v":0.03,"d":"0.030"},0.542,{"v":0.000228,"d":"2.28E-04"},26.02]
["Tumor necrosis factor-alpha","TNFa","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},-0.029,0.042,0.495,{"v":0.000184,"d":"1.84E-04"},21.03]
["Tumor necrosis factor-alpha","TNFa","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},0.005,{"v":0.03,"d":"0.030"},0.871,{"v":0.000196,"d":"1.96E-04"},22.34]
["Tumor necrosis factor-alpha","TNFa","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},0.003,0.065,0.982,{"v":0.000183,"d":"1.83E-04"},20.87]
["Tumor necrosis factor-alpha","TNFa","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.025,0.027,0.341,{"v":0.000198,"d":"1.98E-04"},22.63]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF0a","rs116005451","A","G",2.371,0.513,{"v":3.85e-06,"d":"3.85E-06"},-0.042,0.106,{"v":0.43,"d":"0.430"},{"v":0.000187,"d":"1.87E-04"},21.33]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},{"v":-0.08,"d":"-0.080"},0.062,0.133,{"v":0.000194,"d":"1.94E-04"},22.18]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},0.001,0.023,0.723,{"v":0.000211,"d":"2.11E-04"},24.13]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.015,{"v":0.02,"d":"0.020"},0.358,{"v":0.000211,"d":"2.11E-04"},24.03]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.035,{"v":0.03,"d":"0.030"},0.847,{"v":0.000183,"d":"1.83E-04"},20.84]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.023,0.021,0.119,{"v":0.000228,"d":"2.28E-04"},26.02]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},{"v":0,"d":"0.000"},0.029,0.799,{"v":0.000184,"d":"1.84E-04"},21.03]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.017,{"v":0.02,"d":"0.020"},{"v":0.64,"d":"0.640"},{"v":0.000196,"d":"1.96E-04"},22.34]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},0.051,0.043,0.491,{"v":0.000183,"d":"1.83E-04"},20.87]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.004,0.018,0.862,{"v":0.000198,"d":"1.98E-04"},22.63]
["Stem cell growth factor beta","SCGFb","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},0.007,0.088,0.836,{"v":0.000194,"d":"1.94E-04"},22.18]
["Stem cell growth factor beta","SCGFb","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},-0.053,0.032,0.081,{"v":0.000211,"d":"2.11E-04"},24.13]
["Stem cell growth factor beta","SCGFb","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.005,0.029,0.838,{"v":0.000211,"d":"2.11E-04"},24.03]
["Stem cell growth factor beta","SCGFb","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},-0.018,0.042,0.664,{"v":0.000183,"d":"1.83E-04"},20.84]
["Stem cell growth factor beta","SCGFb","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.002,0.029,0.978,{"v":0.000228,"d":"2.28E-04"},26.02]
["Stem cell growth factor beta","SCGFb","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},-0.047,0.041,{"v":0.25,"d":"0.250"},{"v":0.000184,"d":"1.84E-04"},21.03]
["Stem cell growth factor beta","SCGFb","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.064,0.029,0.027,{"v":0.000196,"d":"1.96E-04"},22.34]
["Stem cell growth factor beta","SCGFb","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},-0.052,0.062,0.341,{"v":0.000183,"d":"1.83E-04"},20.87]
["Stem cell growth factor beta","SCGFb","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.036,0.026,0.158,{"v":0.000198,"d":"1.98E-04"},22.63]
["Stem cell factor","SCF","rs116005451","A","G",2.371,0.513,{"v":3.85e-06,"d":"3.85E-06"},0.001,0.104,0.991,{"v":0.000187,"d":"1.87E-04"},21.33]
["Stem cell factor","SCF","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},-0.019,{"v":0.06,"d":"0.060"},0.665,{"v":0.000194,"d":"1.94E-04"},22.18]
["Stem cell factor","SCF","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},-0.002,0.021,0.949,{"v":0.000211,"d":"2.11E-04"},24.13]
["Stem cell factor","SCF","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.004,0.019,0.824,{"v":0.000211,"d":"2.11E-04"},24.03]
["Stem cell factor","SCF","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.021,0.029,0.493,{"v":0.000183,"d":"1.83E-04"},20.84]
["Stem cell factor","SCF","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},-0.013,{"v":0.02,"d":"0.020"},0.513,{"v":0.000228,"d":"2.28E-04"},26.02]
["Stem cell factor","SCF","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.018,0.028,0.536,{"v":0.000184,"d":"1.84E-04"},21.03]
["Stem cell factor","SCF","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.025,{"v":0.02,"d":"0.020"},0.202,{"v":0.000196,"d":"1.96E-04"},22.34]
["Stem cell factor","SCF","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},-0.009,0.041,0.833,{"v":0.000183,"d":"1.83E-04"},20.87]
["Stem cell factor","SCF","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.013,0.017,0.452,{"v":0.000198,"d":"1.98E-04"},22.63]
["Interleukin-16","IL-16","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},0.054,{"v":0.09,"d":"0.090"},0.565,{"v":0.000194,"d":"1.94E-04"},22.18]
["Interleukin-16","IL-16","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},-0.034,0.032,0.269,{"v":0.000211,"d":"2.11E-04"},24.13]
["Interleukin-16","IL-16","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},-0.008,0.029,0.778,{"v":0.000211,"d":"2.11E-04"},24.03]
["Interleukin-16","IL-16","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.011,0.044,0.806,{"v":0.000183,"d":"1.83E-04"},20.84]
["Interleukin-16","IL-16","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.008,{"v":0.03,"d":"0.030"},0.766,{"v":0.000228,"d":"2.28E-04"},26.02]
["Interleukin-16","IL-16","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.031,0.042,0.461,{"v":0.000184,"d":"1.84E-04"},21.03]
["Interleukin-16","IL-16","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},0.025,{"v":0.03,"d":"0.030"},0.409,{"v":0.000196,"d":"1.96E-04"},22.34]
["Interleukin-16","IL-16","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},-0.039,0.064,0.568,{"v":0.000183,"d":"1.83E-04"},20.87]
["Interleukin-16","IL-16","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.003,0.026,0.898,{"v":0.000198,"d":"1.98E-04"},22.63]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},-0.014,0.092,0.934,{"v":0.000194,"d":"1.94E-04"},22.18]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},-0.026,0.033,{"v":0.37,"d":"0.370"},{"v":0.000211,"d":"2.11E-04"},24.13]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},-0.018,{"v":0.03,"d":"0.030"},0.531,{"v":0.000211,"d":"2.11E-04"},24.03]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},-0.044,0.044,{"v":0.32,"d":"0.320"},{"v":0.000183,"d":"1.83E-04"},20.84]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},-0.009,0.031,0.725,{"v":0.000228,"d":"2.28E-04"},26.02]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.038,0.042,0.364,{"v":0.000184,"d":"1.84E-04"},21.03]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},{"v":-0.05,"d":"-0.050"},0.031,0.105,{"v":0.000196,"d":"1.96E-04"},22.34]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},-0.001,0.066,0.991,{"v":0.000183,"d":"1.83E-04"},20.87]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},-0.014,0.027,{"v":0.6,"d":"0.600"},{"v":0.000198,"d":"1.98E-04"},22.63]
["Platelet derived growth factor BB","PDGFbb","rs116005451","A","G",2.371,0.513,{"v":3.85e-06,"d":"3.85E-06"},-0.052,0.105,0.648,{"v":0.000187,"d":"1.87E-04"},21.33]
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["Basic fibroblast growth factor","bFGF","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.013,0.021,0.561,{"v":0.000228,"d":"2.28E-04"},26.02]
["Basic fibroblast growth factor","bFGF","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.014,0.029,0.617,{"v":0.000184,"d":"1.84E-04"},21.03]
["Basic fibroblast growth factor","bFGF","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},0.001,0.021,0.973,{"v":0.000196,"d":"1.96E-04"},22.34]
["Basic fibroblast growth factor","bFGF","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},0.021,0.043,0.625,{"v":0.000183,"d":"1.83E-04"},20.87]
["Basic fibroblast growth factor","bFGF","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.019,0.018,0.289,{"v":0.000198,"d":"1.98E-04"},22.63]
["Eotaxin (CCL11)","Eotaxin","rs116005451","A","G",2.371,0.513,{"v":3.85e-06,"d":"3.85E-06"},-0.065,0.106,0.572,{"v":0.000187,"d":"1.87E-04"},21.33]
["Eotaxin (CCL11)","Eotaxin","rs143448714","A","G",2.084,0.443,{"v":2.49e-06,"d":"2.49E-06"},0.035,0.061,0.585,{"v":0.000194,"d":"1.94E-04"},22.18]
["Eotaxin (CCL11)","Eotaxin","rs35228278","G","T",{"v":0.58,"d":"0.580"},0.118,{"v":9.09e-07,"d":"9.09E-07"},0.014,0.022,0.558,{"v":0.000211,"d":"2.11E-04"},24.13]
["Eotaxin (CCL11)","Eotaxin","rs4907423","T","G",{"v":0.56,"d":"0.560"},0.114,{"v":9.48e-07,"d":"9.48E-07"},0.012,0.019,0.522,{"v":0.000211,"d":"2.11E-04"},24.03]
["Eotaxin (CCL11)","Eotaxin","rs56249153","T","C",0.663,0.145,{"v":4.99e-06,"d":"4.99E-06"},0.035,0.029,0.255,{"v":0.000183,"d":"1.83E-04"},20.84]
["Eotaxin (CCL11)","Eotaxin","rs6996970","A","C",0.563,{"v":0.11,"d":"0.110"},{"v":3.38e-07,"d":"3.38E-07"},0.014,{"v":0.02,"d":"0.020"},0.538,{"v":0.000228,"d":"2.28E-04"},26.02]
["Eotaxin (CCL11)","Eotaxin","rs7167956","T","C",0.771,0.168,{"v":4.49e-06,"d":"4.49E-06"},0.004,0.028,0.881,{"v":0.000184,"d":"1.84E-04"},21.03]
["Eotaxin (CCL11)","Eotaxin","rs72664690","A","G",0.546,0.116,{"v":2.28e-06,"d":"2.28E-06"},-0.008,{"v":0.02,"d":"0.020"},0.683,{"v":0.000196,"d":"1.96E-04"},22.34]
["Eotaxin (CCL11)","Eotaxin","rs72826162","C","T",1.161,0.254,{"v":4.94e-06,"d":"4.94E-06"},0.012,0.042,0.787,{"v":0.000183,"d":"1.83E-04"},20.87]
["Eotaxin (CCL11)","Eotaxin","rs7530952","G","A",0.461,0.097,{"v":1.98e-06,"d":"1.98E-06"},0.007,0.017,0.669,{"v":0.000198,"d":"1.98E-04"},22.63]
["MR, Mendelian randomization; POI, primary ovarian insufficiency; SNP, single nucleotide polymorphism; SE, standard error."]

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["Table S9 Full result of MR estimates  (POI on Systemic inflammatory regulators)."]
["Systemic inflammatory regulators (Outcome)","Abbreviation","MR method","No. of SNP","b(95%CI)","P-value"]
["Cutaneous T-cell attracting (CCL27)","CTACK","Inverse variance weighted",9,"-0.0056(-0.04,0.0288)",0.75]
["Cutaneous T-cell attracting (CCL27)","CTACK","cML-MA-BIC",9,"-0.0057(-0.0408,0.0295)",0.75]
["Cutaneous T-cell attracting (CCL27)","CTACK","Maximum likelihood",9,"-0.0056(-0.0407,0.0295)",0.75]
["Cutaneous T-cell attracting (CCL27)","CTACK","MR Egger",9,"0.0134(-0.0884,0.1152)",0.8]
["Cutaneous T-cell attracting (CCL27)","CTACK","Weighted median",9,"0.0058(-0.0395,0.0511)",0.8]
["Beta nerve growth factor","bNGF","Inverse variance weighted",9,"0.0131(-0.0222,0.0483)",0.47]
["Beta nerve growth factor","bNGF","cML-MA-BIC",9,"0.0135(-0.0224,0.0494)",0.46]
["Beta nerve growth factor","bNGF","Maximum likelihood",9,"0.0134(-0.0224,0.0493)",0.46]
["Beta nerve growth factor","bNGF","MR Egger",9,"-0.0148(-0.1151,0.0854)",0.78]
["Beta nerve growth factor","bNGF","Weighted median",9,"0.0127(-0.0335,0.0588)",0.59]
["Vascular endothelial growth factor","VEGF","Inverse variance weighted",10,"0.018(-0.0098,0.0457)",0.2]
["Vascular endothelial growth factor","VEGF","cML-MA-BIC",10,"0.0165(-0.0099,0.043)",0.22]
["Vascular endothelial growth factor","VEGF","Maximum likelihood",10,"0.0188(-0.0062,0.0437)",0.14]
["Vascular endothelial growth factor","VEGF","MR Egger",10,"0.0045(-0.07,0.079)",0.91]
["Vascular endothelial growth factor","VEGF","Weighted median",10,"0.0108(-0.0212,0.0428)",0.51]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","Inverse variance weighted",9,"0.0089(-0.0262,0.044)",0.62]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","cML-MA-BIC",9,"0.009(-0.027,0.0449)",0.62]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","Maximum likelihood",9,"0.0092(-0.0266,0.045)",0.61]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","MR Egger",9,"-0.0234(-0.1235,0.0766)",0.66]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","Weighted median",9,"0.0082(-0.0386,0.0551)",0.73]
["TNF-related apoptosis inducing ligand","TRAIL","Inverse variance weighted",9,"0.0074(-0.0158,0.0307)",0.53]
["TNF-related apoptosis inducing ligand","TRAIL","cML-MA-BIC",9,"0.0076(-0.016,0.0311)",0.53]
["TNF-related apoptosis inducing ligand","TRAIL","Maximum likelihood",9,"0.0076(-0.0159,0.0311)",0.53]
["TNF-related apoptosis inducing ligand","TRAIL","MR Egger",9,"-0.0251(-0.0903,0.04)",0.47]
["TNF-related apoptosis inducing ligand","TRAIL","Weighted median",9,"-0.0018(-0.0321,0.0284)",0.91]
["Tumor necrosis factor-beta","TNFb","Inverse variance weighted",7,"-0.064(-0.1546,0.0266)",0.17]
["Tumor necrosis factor-beta","TNFb","cML-MA-BIC",7,"-0.0705(-0.138,-0.0031)",{"v":0.04,"d":"4.00E-02"}]
["Tumor necrosis factor-beta","TNFb","Maximum likelihood",7,"-0.0685(-0.1347,-0.0023)",{"v":0.042,"d":"4.20E-02"}]
["Tumor necrosis factor-beta","TNFb","MR Egger",7,"0.2821(-0.3414,0.9055)",0.42]
["Tumor necrosis factor-beta","TNFb","Weighted median",7,"-0.0617(-0.1513,0.0279)",0.18]
["Tumor necrosis factor-alpha","TNFa","Inverse variance weighted",9,"0.0009(-0.0344,0.0363)",0.96]
["Tumor necrosis factor-alpha","TNFa","cML-MA-BIC",9,"0.001(-0.0346,0.0365)",0.96]
["Tumor necrosis factor-alpha","TNFa","Maximum likelihood",9,"0.001(-0.0346,0.0365)",0.96]
["Tumor necrosis factor-alpha","TNFa","MR Egger",9,"0.0167(-0.0816,0.1151)",0.75]
["Tumor necrosis factor-alpha","TNFa","Weighted median",9,"0.0061(-0.0379,0.05)",0.79]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","Inverse variance weighted",10,"0.0046(-0.0185,0.0277)",0.7]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","cML-MA-BIC",10,"0.0048(-0.0187,0.0284)",0.69]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","Maximum likelihood",10,"0.0048(-0.0187,0.0283)",0.69]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","MR Egger",10,"-0.0184(-0.0767,0.0399)",0.55]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","Weighted median",10,"0.0001(-0.0308,0.0309)",1]
["Stem cell growth factor beta","SCGFb","Inverse variance weighted",9,"-0.0256(-0.0634,0.0121)",0.18]
["Stem cell growth factor beta","SCGFb","cML-MA-BIC",9,"-0.0271(-0.0624,0.0083)",0.13]
["Stem cell growth factor beta","SCGFb","Maximum likelihood",9,"-0.0266(-0.0618,0.0086)",0.14]
["Stem cell growth factor beta","SCGFb","MR Egger",9,"-0.0318(-0.1447,0.0811)",0.6]
["Stem cell growth factor beta","SCGFb","Weighted median",9,"-0.0141(-0.0625,0.0344)",0.57]
["Stem cell factor","SCF","Inverse variance weighted",10,"-0.0018(-0.0241,0.0205)",0.88]
["Stem cell factor","SCF","cML-MA-BIC",10,"-0.0018(-0.0243,0.0207)",0.88]
["Stem cell factor","SCF","Maximum likelihood",10,"-0.0018(-0.0243,0.0207)",0.88]
["Stem cell factor","SCF","MR Egger",10,"-0.0057(-0.0623,0.051)",0.85]
["Stem cell factor","SCF","Weighted median",10,"-0.0029(-0.0311,0.0252)",0.84]
["Interleukin-16","IL-16","Inverse variance weighted",9,"0.0046(-0.0304,0.0397)",0.8]
["Interleukin-16","IL-16","cML-MA-BIC",9,"0.0047(-0.0306,0.0401)",0.79]
["Interleukin-16","IL-16","Maximum likelihood",9,"0.0047(-0.0306,0.04)",0.8]
["Interleukin-16","IL-16","MR Egger",9,"0.0193(-0.0784,0.1169)",0.71]
["Interleukin-16","IL-16","Weighted median",9,"0.015(-0.0277,0.0577)",0.49]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","Inverse variance weighted",9,"-0.0236(-0.0592,0.0121)",0.2]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","cML-MA-BIC",9,"-0.0241(-0.0605,0.0122)",0.19]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","Maximum likelihood",9,"-0.0242(-0.0606,0.0121)",0.19]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","MR Egger",9,"0.022(-0.0782,0.1223)",0.68]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","Weighted median",9,"-0.0233(-0.067,0.0204)",0.3]
["Platelet derived growth factor BB","PDGFbb","Inverse variance weighted",10,"0.0152(-0.0072,0.0375)",0.18]
["Platelet derived growth factor BB","PDGFbb","cML-MA-BIC",10,"0.0154(-0.0073,0.038)",0.18]
["Platelet derived growth factor BB","PDGFbb","Maximum likelihood",10,"0.0155(-0.0071,0.0381)",0.18]
["Platelet derived growth factor BB","PDGFbb","MR Egger",10,"0.0058(-0.051,0.0627)",0.85]
["Platelet derived growth factor BB","PDGFbb","Weighted median",10,"0.0101(-0.0185,0.0387)",0.49]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","Inverse variance weighted",10,"-0.0152(-0.0394,0.0089)",0.22]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","cML-MA-BIC",10,"-0.0161(-0.0392,0.007)",0.17]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","Maximum likelihood",10,"-0.0159(-0.0388,0.0071)",0.18]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","MR Egger",10,"-0.0537(-0.112,0.0046)",0.11]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","Weighted median",10,"-0.0294(-0.0589,0)",0.05]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","Inverse variance weighted",9,"0.0209(-0.0142,0.0559)",0.24]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","cML-MA-BIC",9,"0.0211(-0.0144,0.0566)",0.24]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","Maximum likelihood",9,"0.0213(-0.0142,0.0568)",0.24]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","MR Egger",9,"-0.0001(-0.098,0.0978)",1]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","Weighted median",9,"0.0124(-0.03,0.0547)",0.57]
["Monokine induced by interferon-gamma (CXCL9)","MIG","Inverse variance weighted",9,"-0.0141(-0.062,0.0337)",0.56]
["Monokine induced by interferon-gamma (CXCL9)","MIG","cML-MA-BIC",9,"-0.0156(-0.0514,0.0202)",0.39]
["Monokine induced by interferon-gamma (CXCL9)","MIG","Maximum likelihood",9,"-0.0148(-0.0502,0.0207)",0.41]
["Monokine induced by interferon-gamma (CXCL9)","MIG","MR Egger",9,"0.0025(-0.1401,0.1451)",0.97]
["Monokine induced by interferon-gamma (CXCL9)","MIG","Weighted median",9,"-0.0298(-0.0798,0.0202)",0.24]
["Macrophage colony-stimulating factor","MCSF","Inverse variance weighted",9,"-0.0071(-0.0495,0.0352)",0.74]
["Macrophage colony-stimulating factor","MCSF","cML-MA-BIC",9,"-0.0072(-0.0503,0.0358)",0.74]
["Macrophage colony-stimulating factor","MCSF","Maximum likelihood",9,"-0.0073(-0.0503,0.0356)",0.74]
["Macrophage colony-stimulating factor","MCSF","MR Egger",9,"0.0423(-0.0798,0.1644)",0.52]
["Macrophage colony-stimulating factor","MCSF","Weighted median",9,"-0.0016(-0.0542,0.051)",0.95]
["Monocyte specific chemokine 3 (CCL7)","MCP3","Inverse variance weighted",9,"-0.033(-0.1041,0.0382)",0.36]
["Monocyte specific chemokine 3 (CCL7)","MCP3","cML-MA-BIC",9,"-0.0348(-0.0997,0.0301)",0.29]
["Monocyte specific chemokine 3 (CCL7)","MCP3","Maximum likelihood",9,"-0.0344(-0.0991,0.0303)",0.3]
["Monocyte specific chemokine 3 (CCL7)","MCP3","MR Egger",9,"0.0128(-0.1985,0.2241)",0.91]
["Monocyte specific chemokine 3 (CCL7)","MCP3","Weighted median",9,"-0.0509(-0.1382,0.0363)",0.25]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","Inverse variance weighted",10,"-0.0024(-0.0279,0.0231)",0.85]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","cML-MA-BIC",10,"-0.0021(-0.0254,0.0213)",0.86]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","Maximum likelihood",10,"-0.0025(-0.0255,0.0205)",0.83]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","MR Egger",10,"0.0302(-0.034,0.0944)",0.38]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","Weighted median",10,"-0.0055(-0.0356,0.0246)",0.72]
["Interleukin-12p70","IL-12p70","Inverse variance weighted",10,"0.014(-0.0147,0.0426)",0.34]
["Interleukin-12p70","IL-12p70","cML-MA-BIC",10,"0.0124(-0.0126,0.0373)",0.33]
["Interleukin-12p70","IL-12p70","Maximum likelihood",10,"0.0147(-0.0085,0.0379)",0.21]
["Interleukin-12p70","IL-12p70","MR Egger",10,"0.0012(-0.0751,0.0776)",0.98]
["Interleukin-12p70","IL-12p70","Weighted median",10,"0.0015(-0.0279,0.0309)",0.92]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","Inverse variance weighted",9,"-0.0058(-0.0456,0.034)",0.77]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","cML-MA-BIC",9,"-0.0063(-0.0414,0.0289)",0.73]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","Maximum likelihood",9,"-0.0061(-0.0412,0.029)",0.73]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","MR Egger",9,"-0.0228(-0.1408,0.0953)",0.72]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","Weighted median",9,"-0.0225(-0.0713,0.0262)",0.36]
["Interleukin-18","IL-18","Inverse variance weighted",10,"-0.0081(-0.0504,0.0341)",0.71]
["Interleukin-18","IL-18","cML-MA-BIC",10,"-0.0065(-0.0421,0.0291)",0.72]
["Interleukin-18","IL-18","Maximum likelihood",10,"-0.0085(-0.043,0.026)",0.63]
["Interleukin-18","IL-18","MR Egger",10,"-0.0499(-0.1635,0.0636)",0.41]
["Interleukin-18","IL-18","Weighted median",10,"0.0108(-0.0334,0.055)",0.63]
["Interleukin-17","IL-17","Inverse variance weighted",10,"-0.0011(-0.0242,0.022)",0.92]
["Interleukin-17","IL-17","cML-MA-BIC",10,"-0.0012(-0.0245,0.0222)",0.92]
["Interleukin-17","IL-17","Maximum likelihood",10,"-0.0011(-0.0244,0.0222)",0.92]
["Interleukin-17","IL-17","MR Egger",10,"0.0026(-0.0559,0.0612)",0.93]
["Interleukin-17","IL-17","Weighted median",10,"-0.0078(-0.0377,0.0221)",0.61]
["Interleukin-13","IL-13","Inverse variance weighted",9,"0.025(-0.0169,0.0669)",0.24]
["Interleukin-13","IL-13","cML-MA-BIC",9,"0.0228(-0.0157,0.0613)",0.25]
["Interleukin-13","IL-13","Maximum likelihood",9,"0.0251(-0.0109,0.061)",0.17]
["Interleukin-13","IL-13","MR Egger",9,"0.0095(-0.1149,0.1339)",0.89]
["Interleukin-13","IL-13","Weighted median",9,"-0.0027(-0.0461,0.0407)",0.9]
["Interleukin-10","IL-10","Inverse variance weighted",10,"0.0077(-0.0155,0.031)",0.51]
["Interleukin-10","IL-10","cML-MA-BIC",10,"0.0081(-0.0157,0.0318)",0.5]
["Interleukin-10","IL-10","Maximum likelihood",10,"0.0078(-0.0158,0.0315)",0.52]
["Interleukin-10","IL-10","MR Egger",10,"-0.0237(-0.0832,0.0359)",0.46]
["Interleukin-10","IL-10","Weighted median",10,"-0.0007(-0.0319,0.0305)",0.96]
["Interleukin-8 (CXCL8)","IL-8","Inverse variance weighted",9,"0.0209(-0.0141,0.0559)",0.24]
["Interleukin-8 (CXCL8)","IL-8","cML-MA-BIC",9,"0.0213(-0.0143,0.0568)",0.24]
["Interleukin-8 (CXCL8)","IL-8","Maximum likelihood",9,"0.0213(-0.0142,0.0567)",0.24]
["Interleukin-8 (CXCL8)","IL-8","MR Egger",9,"0.028(-0.0701,0.1261)",0.59]
["Interleukin-8 (CXCL8)","IL-8","Weighted median",9,"0.0113(-0.0343,0.0569)",0.63]
["Interleukin-6","IL-6","Inverse variance weighted",9,"0.0072(-0.0166,0.0311)",0.55]
["Interleukin-6","IL-6","cML-MA-BIC",9,"0.0076(-0.0162,0.0315)",0.53]
["Interleukin-6","IL-6","Maximum likelihood",9,"0.0075(-0.0163,0.0313)",0.54]
["Interleukin-6","IL-6","MR Egger",9,"0.0176(-0.0536,0.0888)",0.64]
["Interleukin-6","IL-6","Weighted median",9,"0.002(-0.0286,0.0326)",0.9]
["Interleukin-1 receptor antagonist","IL1ra","Inverse variance weighted",9,"0.0149(-0.0196,0.0495)",0.4]
["Interleukin-1 receptor antagonist","IL1ra","cML-MA-BIC",9,"0.0148(-0.0206,0.0503)",0.41]
["Interleukin-1 receptor antagonist","IL1ra","Maximum likelihood",9,"0.0154(-0.0197,0.0505)",0.39]
["Interleukin-1 receptor antagonist","IL1ra","MR Egger",9,"0.0408(-0.0566,0.1382)",0.44]
["Interleukin-1 receptor antagonist","IL1ra","Weighted median",9,"0.0132(-0.0302,0.0566)",0.55]
["Interleukin-1-beta","IL-1b","Inverse variance weighted",10,"0.01(-0.023,0.0429)",0.55]
["Interleukin-1-beta","IL-1b","cML-MA-BIC",10,"0.0107(-0.0172,0.0386)",0.45]
["Interleukin-1-beta","IL-1b","Maximum likelihood",10,"0.0105(-0.0172,0.0383)",0.46]
["Interleukin-1-beta","IL-1b","MR Egger",10,"0.0546(-0.0319,0.141)",0.25]
["Interleukin-1-beta","IL-1b","Weighted median",10,"0.0055(-0.0305,0.0416)",0.76]
["Hepatocyte growth factor","HGF","Inverse variance weighted",9,"0.0098(-0.0133,0.033)",0.41]
["Hepatocyte growth factor","HGF","cML-MA-BIC",9,"0.0106(-0.0135,0.0348)",0.39]
["Hepatocyte growth factor","HGF","Maximum likelihood",9,"0.0103(-0.0135,0.0342)",0.4]
["Hepatocyte growth factor","HGF","MR Egger",9,"-0.0469(-0.1119,0.0182)",0.2]
["Hepatocyte growth factor","HGF","Weighted median",9,"0.0192(-0.0122,0.0505)",0.23]
["Interleukin-9","IL-9","Inverse variance weighted",9,"-0.007(-0.0441,0.0301)",0.71]
["Interleukin-9","IL-9","cML-MA-BIC",9,"-0.0066(-0.0426,0.0294)",0.72]
["Interleukin-9","IL-9","Maximum likelihood",9,"-0.0072(-0.0426,0.0282)",0.69]
["Interleukin-9","IL-9","MR Egger",9,"0.0179(-0.0915,0.1273)",0.76]
["Interleukin-9","IL-9","Weighted median",9,"0.0048(-0.041,0.0506)",0.84]
["Interleukin-7","IL-7","Inverse variance weighted",9,"0.0301(-0.0056,0.0659)",0.1]
["Interleukin-7","IL-7","cML-MA-BIC",9,"0.0308(-0.0058,0.0675)",0.1]
["Interleukin-7","IL-7","Maximum likelihood",9,"0.031(-0.0056,0.0676)",0.1]
["Interleukin-7","IL-7","MR Egger",9,"0.0198(-0.0807,0.1203)",0.71]
["Interleukin-7","IL-7","Weighted median",9,"0.0311(-0.015,0.0773)",0.19]
["Interleukin-5","IL-5","Inverse variance weighted",9,"0.0107(-0.0261,0.0474)",0.57]
["Interleukin-5","IL-5","cML-MA-BIC",9,"0.0108(-0.026,0.0475)",0.57]
["Interleukin-5","IL-5","Maximum likelihood",9,"0.0111(-0.0254,0.0476)",0.55]
["Interleukin-5","IL-5","MR Egger",9,"-0.0108(-0.1184,0.0969)",0.85]
["Interleukin-5","IL-5","Weighted median",9,"0.0081(-0.0384,0.0545)",0.73]
["Interleukin-4","IL-4","Inverse variance weighted",10,"0.0084(-0.0142,0.031)",0.47]
["Interleukin-4","IL-4","cML-MA-BIC",10,"0.0085(-0.0143,0.0312)",0.47]
["Interleukin-4","IL-4","Maximum likelihood",10,"0.0085(-0.0143,0.0312)",0.47]
["Interleukin-4","IL-4","MR Egger",10,"0.0098(-0.0475,0.0672)",0.75]
["Interleukin-4","IL-4","Weighted median",10,"0.0092(-0.0182,0.0365)",0.51]
["Interleukin-2 receptor, alpha subunit","IL2ra","Inverse variance weighted",9,"-0.0203(-0.0617,0.0211)",0.34]
["Interleukin-2 receptor, alpha subunit","IL2ra","cML-MA-BIC",9,"-0.0216(-0.057,0.0137)",0.23]
["Interleukin-2 receptor, alpha subunit","IL2ra","Maximum likelihood",9,"-0.0214(-0.0565,0.0138)",0.23]
["Interleukin-2 receptor, alpha subunit","IL2ra","MR Egger",9,"-0.0139(-0.1378,0.1101)",0.83]
["Interleukin-2 receptor, alpha subunit","IL2ra","Weighted median",9,"-0.0128(-0.0609,0.0352)",0.6]
["Interleukin-2","IL-2","Inverse variance weighted",9,"0.0221(-0.0131,0.0574)",0.22]
["Interleukin-2","IL-2","cML-MA-BIC",9,"0.0226(-0.0132,0.0584)",0.22]
["Interleukin-2","IL-2","Maximum likelihood",9,"0.0222(-0.0135,0.0579)",0.22]
["Interleukin-2","IL-2","MR Egger",9,"0.0308(-0.0682,0.1298)",0.56]
["Interleukin-2","IL-2","Weighted median",9,"0.0317(-0.0131,0.0765)",0.17]
["Interferon-gamma","IFNg","Inverse variance weighted",10,"0.005(-0.0183,0.0282)",0.67]
["Interferon-gamma","IFNg","cML-MA-BIC",10,"0.005(-0.0186,0.0285)",0.68]
["Interferon-gamma","IFNg","Maximum likelihood",10,"0.0051(-0.0184,0.0285)",0.67]
["Interferon-gamma","IFNg","MR Egger",10,"-0.0056(-0.0649,0.0537)",0.86]
["Interferon-gamma","IFNg","Weighted median",10,"0.0025(-0.0259,0.031)",0.86]
["Growth regulated oncogene-α (CXCL1)","GROa","Inverse variance weighted",9,"-0.0055(-0.0668,0.0557)",0.86]
["Growth regulated oncogene-α (CXCL1)","GROa","cML-MA-BIC",9,"0.0133(-0.0292,0.0558)",0.54]
["Growth regulated oncogene-α (CXCL1)","GROa","Maximum likelihood",9,"-0.0061(-0.0432,0.0309)",0.75]
["Growth regulated oncogene-α (CXCL1)","GROa","MR Egger",9,"0.0399(-0.1389,0.2188)",0.67]
["Growth regulated oncogene-α (CXCL1)","GROa","Weighted median",9,"0.0087(-0.0431,0.0604)",0.74]
["Granulocyte colony-stimulating factor","GCSF","Inverse variance weighted",10,"0.0202(-0.0027,0.043)",0.08]
["Granulocyte colony-stimulating factor","GCSF","cML-MA-BIC",10,"0.0212(-0.0026,0.045)",0.08]
["Granulocyte colony-stimulating factor","GCSF","Maximum likelihood",10,"0.0211(-0.0026,0.0447)",0.08]
["Granulocyte colony-stimulating factor","GCSF","MR Egger",10,"-0.0046(-0.0625,0.0533)",0.88]
["Granulocyte colony-stimulating factor","GCSF","Weighted median",10,"0.0193(-0.0121,0.0507)",0.23]
["Basic fibroblast growth factor","bFGF","Inverse variance weighted",10,"0.0176(-0.0057,0.0409)",0.14]
["Basic fibroblast growth factor","bFGF","cML-MA-BIC",10,"0.018(-0.0058,0.0418)",0.14]
["Basic fibroblast growth factor","bFGF","Maximum likelihood",10,"0.0179(-0.0059,0.0416)",0.14]
["Basic fibroblast growth factor","bFGF","MR Egger",10,"0.0084(-0.0508,0.0676)",0.79]
["Basic fibroblast growth factor","bFGF","Weighted median",10,"0.0185(-0.011,0.0481)",0.22]
["Eotaxin (CCL11)","Eotaxin","Inverse variance weighted",10,"0.013(-0.0095,0.0356)",0.26]
["Eotaxin (CCL11)","Eotaxin","cML-MA-BIC",10,"0.0132(-0.0096,0.0359)",0.26]
["Eotaxin (CCL11)","Eotaxin","Maximum likelihood",10,"0.0133(-0.0095,0.036)",0.25]
["Eotaxin (CCL11)","Eotaxin","MR Egger",10,"0.002(-0.0554,0.0593)",0.95]
["Eotaxin (CCL11)","Eotaxin","Weighted median",10,"0.0164(-0.0116,0.0443)",0.25]
["MR, Mendelian randomization; POI, primary ovarian insufficiency; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; IVW, inverse variance weighted; ML, maximum likelihood."]

{"sheet":"sheet10","index":9,"n_rows":44,"n_cols":6,"rows_kept":44,"merged":[[0,0,0,5],[43,0,43,5]],"flags":["formulas_cached_only"]}
["Table S10 The heterogeneity of POI instrumental variables (POI on Systemic inflammatory regulators)."]
["Systemic inflammatory regulators (Outcome)","Abbreviation","Cochran's Q","df","P-value","I2(%)"]
["Cutaneous T-cell attracting (CCL27)","CTACK",7.994,8,0.434,{"v":0,"d":"0.00"}]
["Beta nerve growth factor","bNGF",5.702,8,0.681,{"v":0,"d":"0.00"}]
["Vascular endothelial growth factor","VEGF",11.859,9,0.221,24.11]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF",{"v":7.65,"d":"7.650"},8,0.468,{"v":0,"d":"0.00"}]
["TNF-related apoptosis inducing ligand","TRAIL",{"v":4.28,"d":"4.280"},8,0.831,{"v":0,"d":"0.00"}]
["Tumor necrosis factor-beta","TNFb",12.555,6,0.051,52.21]
["Tumor necrosis factor-alpha","TNFa",2.646,8,0.955,{"v":0,"d":"0.00"}]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a",7.078,9,0.629,{"v":0,"d":"0.00"}]
["Stem cell growth factor beta","SCGFb",9.752,8,0.283,17.97]
["Stem cell factor","SCF",3.759,9,0.927,{"v":0,"d":"0.00"}]
["Interleukin-16","IL-16",3.253,8,0.918,{"v":0,"d":"0.00"}]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES",4.151,8,0.843,{"v":0,"d":"0.00"}]
["Platelet derived growth factor BB","PDGFbb",3.288,9,0.952,{"v":0,"d":"0.00"}]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b",10.501,9,0.311,{"v":14.3,"d":"14.30"}]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a",2.419,8,0.965,{"v":0,"d":"0.00"}]
["Monokine induced by interferon-gamma (CXCL9)","MIG",15.687,8,0.047,{"v":49,"d":"49.00"}]
["Macrophage colony-stimulating factor","MCSF",6.427,8,0.599,{"v":0,"d":"0.00"}]
["Monocyte specific chemokine 3 (CCL7)","MCP3",10.168,8,0.253,21.32]
["Monocyte chemotactic protein-1 (CCL2)","MCP1",11.668,9,0.233,22.86]
["Interleukin-12p70","IL-12p70",14.714,9,0.099,38.83]
["Interferon gamma-induced protein 10 (CXCL10)","IP10",10.806,8,0.213,25.96]
["Interleukin-18","IL-18",14.146,9,0.117,36.38]
["Interleukin-17","IL-17",5.184,9,0.818,{"v":0,"d":"0.00"}]
["Interleukin-13","IL-13",11.536,8,0.173,30.65]
["Interleukin-10","IL-10",6.917,9,0.646,{"v":0,"d":"0.00"}]
["Interleukin-8 (CXCL8)","IL-8",4.119,8,0.846,{"v":0,"d":"0.00"}]
["Interleukin-6","IL-6",8.372,8,0.398,4.44]
["Interleukin-1 receptor antagonist","IL1ra",7.379,8,0.496,{"v":0,"d":"0.00"}]
["Interleukin-1-beta","IL-1b",13.473,9,0.142,{"v":33.2,"d":"33.20"}]
["Hepatocyte growth factor","HGF",7.926,8,0.441,{"v":0,"d":"0.00"}]
["Interleukin-9","IL-9",9.219,8,0.324,13.23]
["Interleukin-7","IL-7",5.834,8,0.666,{"v":0,"d":"0.00"}]
["Interleukin-5","IL-5",8.437,8,0.392,5.18]
["Interleukin-4","IL-4",1.847,9,0.994,{"v":0,"d":"0.00"}]
["Interleukin-2 receptor, alpha subunit","IL2ra",11.732,8,0.164,31.81]
["Interleukin-2","IL-2",5.166,8,{"v":0.74,"d":"0.740"},{"v":0,"d":"0.00"}]
["Interferon-gamma","IFNg",5.213,9,0.815,{"v":0,"d":"0.00"}]
["Growth regulated oncogene-α (CXCL1)","GROa",24.523,8,0.002,67.38]
["Granulocyte colony-stimulating factor","GCSF",7.422,9,0.593,{"v":0,"d":"0.00"}]
["Basic fibroblast growth factor","bFGF",4.242,9,0.895,{"v":0,"d":"0.00"}]
["Eotaxin (CCL11)","Eotaxin",2.512,9,0.981,{"v":0,"d":"0.00"}]
["Df, degree of freedom; POI, primary ovarian insufficiency."]

{"sheet":"sheet11","index":10,"n_rows":44,"n_cols":5,"rows_kept":44,"merged":[[0,0,0,4],[43,0,43,4]],"flags":["formulas_cached_only"]}
["Table S11 Directional horizontal pleiotropy assessed by intercept term in MR Egger regression (POI on Systemic inflammatory regulators)."]
["Systemic inflammatory regulators (Outcome)","Abbreviation","Egger_intercept","SE","P-value"]
["Cutaneous T-cell attracting (CCL27)","CTACK",-0.013,0.034,0.708]
["Beta nerve growth factor","bNGF",0.019,0.033,0.578]
["Vascular endothelial growth factor","VEGF",{"v":0.01,"d":"0.010"},0.026,0.711]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF",0.023,0.033,{"v":0.52,"d":"0.520"}]
["TNF-related apoptosis inducing ligand","TRAIL",0.023,0.022,0.329]
["Tumor necrosis factor-beta","TNFb",{"v":-0.2,"d":"-0.200"},0.182,0.322]
["Tumor necrosis factor-alpha","TNFa",-0.011,0.033,0.746]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a",0.017,{"v":0.02,"d":"0.020"},0.424]
["Stem cell growth factor beta","SCGFb",0.004,0.038,0.912]
["Stem cell factor","SCF",0.003,0.019,0.887]
["Interleukin-16","IL-16",{"v":-0.01,"d":"-0.010"},0.033,0.762]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES",-0.032,0.033,0.372]
["Platelet derived growth factor BB","PDGFbb",0.007,{"v":0.02,"d":"0.020"},0.736]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b",0.028,{"v":0.02,"d":"0.020"},0.197]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a",0.015,0.033,0.666]
["Monokine induced by interferon-gamma (CXCL9)","MIG",-0.012,0.048,0.814]
["Macrophage colony-stimulating factor","MCSF",-0.034,{"v":0.04,"d":"0.040"},0.425]
["Monocyte specific chemokine 3 (CCL7)","MCP3",-0.032,0.071,0.664]
["Monocyte chemotactic protein-1 (CCL2)","MCP1",-0.024,0.022,0.311]
["Interleukin-12p70","IL-12p70",0.009,0.026,0.732]
["Interferon gamma-induced protein 10 (CXCL10)","IP10",0.012,0.039,0.772]
["Interleukin-18","IL-18",{"v":0.03,"d":"0.030"},0.039,0.458]
["Interleukin-17","IL-17",-0.003,{"v":0.02,"d":"0.020"},0.894]
["Interleukin-13","IL-13",0.011,0.042,0.801]
["Interleukin-10","IL-10",0.023,{"v":0.02,"d":"0.020"},0.294]
["Interleukin-8 (CXCL8)","IL-8",-0.005,0.033,0.885]
["Interleukin-6","IL-6",-0.007,0.024,0.769]
["Interleukin-1 receptor antagonist","IL1ra",-0.018,0.033,0.595]
["Interleukin-1-beta","IL-1b",-0.032,0.029,0.307]
["Hepatocyte growth factor","HGF",{"v":0.04,"d":"0.040"},0.022,{"v":0.11,"d":"0.110"}]
["Interleukin-9","IL-9",-0.017,0.037,0.648]
["Interleukin-7","IL-7",0.007,0.034,0.835]
["Interleukin-5","IL-5",0.015,0.036,0.688]
["Interleukin-4","IL-4",-0.001,{"v":0.02,"d":"0.020"},{"v":0.96,"d":"0.960"}]
["Interleukin-2 receptor, alpha subunit","IL2ra",-0.005,0.041,0.916]
["Interleukin-2","IL-2",-0.006,0.033,{"v":0.86,"d":"0.860"}]
["Interferon-gamma","IFNg",0.008,{"v":0.02,"d":"0.020"},0.714]
["Growth regulated oncogene-α (CXCL1)","GROa",-0.032,{"v":0.06,"d":"0.060"},{"v":0.61,"d":"0.610"}]
["Granulocyte colony-stimulating factor","GCSF",0.018,{"v":0.02,"d":"0.020"},0.388]
["Basic fibroblast growth factor","bFGF",0.007,{"v":0.02,"d":"0.020"},0.749]
["Eotaxin (CCL11)","Eotaxin",0.008,{"v":0.02,"d":"0.020"},0.691]
["MR, Mendelian randomization; POI, primary ovarian insufficiency; SE, standard error."]

{"sheet":"sheet12","index":11,"n_rows":45,"n_cols":10,"rows_kept":45,"merged":[[0,0,0,9],[44,0,44,9]],"flags":["formulas_cached_only"]}
["Table S12 MR-PRESSO analysis (POI on Systemic inflammatory regulators)."]
["Systemic inflammatory regulators (Outcome)","Abbreviation","MR Analysis","Causal Estimate","SD","T","P-value","RSSobs","Global test P-value","Remove SNP"]
["Cutaneous T-cell attracting (CCL27)","CTACK","MR-PRESSO",-0.006,0.018,-0.317,0.759,10.021,0.443,0]
["Beta nerve growth factor","bNGF","MR-PRESSO",0.013,0.015,{"v":0.86,"d":"0.860"},0.415,7.227,0.678,0]
["Vascular endothelial growth factor","VEGF","MR-PRESSO",0.018,0.014,1.269,0.236,14.131,{"v":0.28,"d":"0.280"},0]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","MR-PRESSO",0.009,0.018,0.507,0.626,9.605,0.471,0]
["TNF-related apoptosis inducing ligand","TRAIL","MR-PRESSO",0.007,0.009,0.859,0.415,5.449,0.824,0]
["Tumor necrosis factor-beta","TNFb","MR-PRESSO",-0.064,0.046,-1.384,0.216,17.193,0.065,0]
["Tumor necrosis factor-alpha","TNFa","MR-PRESSO",0.001,{"v":0.01,"d":"0.010"},{"v":0.09,"d":"0.090"},{"v":0.93,"d":"0.930"},3.246,0.955,0]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","MR-PRESSO",0.005,{"v":0.01,"d":"0.010"},0.441,0.669,8.996,{"v":0.64,"d":"0.640"},0]
["Stem cell growth factor beta","SCGFb","MR-PRESSO",-0.026,0.019,-1.331,{"v":0.22,"d":"0.220"},12.242,0.321,0]
["Stem cell factor","SCF","MR-PRESSO",-0.002,0.007,-0.241,0.815,4.601,0.934,0]
["Interleukin-16","IL-16","MR-PRESSO",0.005,0.011,0.405,0.696,4.113,0.905,0]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","MR-PRESSO",-0.024,0.013,-1.796,{"v":0.11,"d":"0.110"},5.215,0.844,0]
["Platelet derived growth factor BB","PDGFbb","MR-PRESSO",0.015,0.007,2.197,0.056,4.018,0.966,0]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","MR-PRESSO",-0.015,0.012,-1.236,0.248,{"v":13.12,"d":"13.120"},0.337,0]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","MR-PRESSO",0.021,{"v":0.01,"d":"0.010"},2.123,0.067,3.108,{"v":0.96,"d":"0.960"},0]
["Monokine induced by interferon-gamma (CXCL9)","MIG","MR-PRESSO",-0.014,0.024,-0.578,0.579,{"v":19.6,"d":"19.600"},0.052,0]
["Macrophage colony-stimulating factor","MCSF","MR-PRESSO",-0.007,0.019,-0.369,0.721,7.977,0.616,0]
["Monocyte specific chemokine 3 (CCL7)","MCP3","MR-PRESSO",-0.033,0.036,-0.908,{"v":0.39,"d":"0.390"},12.711,0.296,0]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","MR-PRESSO",-0.002,0.013,-0.184,0.858,14.603,0.248,0]
["Interleukin-12p70","IL-12p70","MR-PRESSO",0.014,0.015,0.956,0.364,17.764,0.122,0]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","MR-PRESSO",-0.006,{"v":0.02,"d":"0.020"},-0.287,0.782,{"v":13.45,"d":"13.450"},0.236,0]
["Interleukin-18","IL-18","MR-PRESSO",-0.008,0.022,-0.377,0.715,16.301,0.174,0]
["Interleukin-17","IL-17","MR-PRESSO",-0.001,0.009,-0.125,0.903,6.263,0.835,0]
["Interleukin-13","IL-13","MR-PRESSO",0.025,0.021,1.171,0.275,13.927,0.216,0]
["Interleukin-10","IL-10","MR-PRESSO",0.008,{"v":0.01,"d":"0.010"},0.746,0.475,8.683,{"v":0.66,"d":"0.660"},0]
["Interleukin-8 (CXCL8)","IL-8","MR-PRESSO",0.021,0.013,1.633,0.141,5.009,0.849,0]
["Interleukin-6","IL-6","MR-PRESSO",0.007,0.012,0.594,0.569,10.264,0.427,0]
["Interleukin-1 receptor antagonist","IL1ra","MR-PRESSO",0.015,0.017,0.884,0.403,8.772,0.545,0]
["Interleukin-1-beta","IL-1b","MR-PRESSO",{"v":0.01,"d":"0.010"},0.017,0.593,0.568,{"v":15.99,"d":"15.990"},0.188,0]
["Hepatocyte growth factor","HGF","MR-PRESSO",{"v":0.01,"d":"0.010"},0.012,0.836,0.428,10.585,0.421,0]
["Interleukin-9","IL-9","MR-PRESSO",-0.007,0.019,-0.371,{"v":0.72,"d":"0.720"},11.533,0.357,0]
["Interleukin-7","IL-7","MR-PRESSO",{"v":0.03,"d":"0.030"},0.016,1.938,0.089,7.138,0.701,0]
["Interleukin-5","IL-5","MR-PRESSO",0.011,0.019,0.569,0.585,10.276,0.432,0]
["Interleukin-4","IL-4","MR-PRESSO",0.008,0.005,1.608,0.142,2.221,0.996,0]
["Interleukin-2 receptor, alpha subunit","IL2ra","MR-PRESSO",{"v":-0.02,"d":"-0.020"},0.021,{"v":-0.96,"d":"-0.960"},0.365,14.375,{"v":0.19,"d":"0.190"},0]
["Interleukin-2","IL-2","MR-PRESSO",0.022,0.014,1.532,0.164,6.387,0.761,0]
["Interferon-gamma","IFNg","MR-PRESSO",0.005,0.009,0.551,0.595,6.201,0.844,0]
["Growth regulated oncogene-α (CXCL1)","GROa","MR-PRESSO",-0.006,0.031,-0.176,0.864,30.264,0.005,1]
["Growth regulated oncogene-α (CXCL1)","GROa","Outlier-corrected MR-PRESSO",0.018,0.022,0.802,0.449,12.357,0.235,0]
["Granulocyte colony-stimulating factor","GCSF","MR-PRESSO",{"v":0.02,"d":"0.020"},0.011,1.904,0.089,9.692,0.583,0]
["Basic fibroblast growth factor","bFGF","MR-PRESSO",0.018,0.008,2.156,0.059,5.241,0.906,0]
["Eotaxin (CCL11)","Eotaxin","MR-PRESSO",0.013,0.006,2.142,0.061,{"v":2.97,"d":"2.970"},0.989,0]
["MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; POI, primary ovarian insufficiency; SD, standard deviation; RSSobs, observed residual sum of squares; SNP, single nucleotide polymorphism."]

{"sheet":"sheet13","index":12,"n_rows":44,"n_cols":6,"rows_kept":44,"merged":[[0,0,0,5],[43,0,43,5]],"flags":["formulas_cached_only"]}
["Table S13 MR steiger test (POI on Systemic inflammatory regulators)."]
["Systemic inflammatory regulators (Outcome)","Abbreviation","snp_r2.exposure","snp_r2.outcome","correct_causal_direction","steiger_pval"]
["Cutaneous T-cell attracting (CCL27)","CTACK",{"v":0.00112,"d":"1.12E-03"},{"v":0.00226,"d":"2.26E-03"},false,{"v":0.399,"d":"3.99E-01"}]
["Beta nerve growth factor","bNGF",{"v":0.00112,"d":"1.12E-03"},{"v":0.00178,"d":"1.78E-03"},false,{"v":0.608,"d":"6.08E-01"}]
["Vascular endothelial growth factor","VEGF",{"v":0.00124,"d":"1.24E-03"},{"v":0.00193,"d":"1.93E-03"},false,{"v":0.467,"d":"4.67E-01"}]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF",{"v":0.00112,"d":"1.12E-03"},{"v":0.00234,"d":"2.34E-03"},false,{"v":0.383,"d":"3.83E-01"}]
["TNF-related apoptosis inducing ligand","TRAIL",{"v":0.00112,"d":"1.12E-03"},{"v":0.000576,"d":"5.76E-04"},true,{"v":0.402,"d":"4.02E-01"}]
["Tumor necrosis factor-beta","TNFb",{"v":0.000884,"d":"8.84E-04"},{"v":0.0109,"d":"1.09E-02"},false,{"v":0.00321,"d":"3.21E-03"}]
["Tumor necrosis factor-alpha","TNFa",{"v":0.00112,"d":"1.12E-03"},{"v":0.000786,"d":"7.86E-04"},true,{"v":0.752,"d":"7.52E-01"}]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a",{"v":0.00124,"d":"1.24E-03"},{"v":0.00118,"d":"1.18E-03"},true,{"v":0.955,"d":"9.55E-01"}]
["Stem cell growth factor beta","SCGFb",{"v":0.00112,"d":"1.12E-03"},{"v":0.00338,"d":"3.38E-03"},false,{"v":0.138,"d":"1.38E-01"}]
["Stem cell factor","SCF",{"v":0.00124,"d":"1.24E-03"},{"v":0.000453,"d":"4.53E-04"},true,{"v":0.216,"d":"2.16E-01"}]
["Interleukin-16","IL-16",{"v":0.00112,"d":"1.12E-03"},{"v":0.000963,"d":"9.63E-04"},true,{"v":0.887,"d":"8.87E-01"}]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES",{"v":0.00112,"d":"1.12E-03"},{"v":0.00177,"d":"1.77E-03"},false,{"v":0.617,"d":"6.17E-01"}]
["Platelet derived growth factor BB","PDGFbb",{"v":0.00124,"d":"1.24E-03"},{"v":0.000593,"d":"5.93E-04"},true,{"v":0.335,"d":"3.35E-01"}]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b",{"v":0.00124,"d":"1.24E-03"},{"v":0.00151,"d":"1.51E-03"},false,{"v":0.74,"d":"7.40E-01"}]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a",{"v":0.00112,"d":"1.12E-03"},{"v":0.00106,"d":"1.06E-03"},true,{"v":0.955,"d":"9.55E-01"}]
["Monokine induced by interferon-gamma (CXCL9)","MIG",{"v":0.00112,"d":"1.12E-03"},{"v":0.00446,"d":"4.46E-03"},false,{"v":0.0448,"d":"4.48E-02"}]
["Macrophage colony-stimulating factor","MCSF",{"v":0.00112,"d":"1.12E-03"},{"v":0.008,"d":"8.00E-03"},false,{"v":0.105,"d":"1.05E-01"}]
["Monocyte specific chemokine 3 (CCL7)","MCP3",{"v":0.00112,"d":"1.12E-03"},{"v":0.0128,"d":"1.28E-02"},false,{"v":0.0206,"d":"2.06E-02"}]
["Monocyte chemotactic protein-1 (CCL2)","MCP1",{"v":0.00124,"d":"1.24E-03"},{"v":0.00142,"d":"1.42E-03"},false,{"v":0.827,"d":"8.27E-01"}]
["Interleukin-12p70","IL-12p70",{"v":0.00124,"d":"1.24E-03"},{"v":0.00192,"d":"1.92E-03"},false,{"v":0.442,"d":"4.42E-01"}]
["Interferon gamma-induced protein 10 (CXCL10)","IP10",{"v":0.00112,"d":"1.12E-03"},{"v":0.0029,"d":"2.90E-03"},false,{"v":0.221,"d":"2.21E-01"}]
["Interleukin-18","IL-18",{"v":0.00124,"d":"1.24E-03"},{"v":0.00403,"d":"4.03E-03"},false,{"v":0.09,"d":"9.00E-02"}]
["Interleukin-17","IL-17",{"v":0.00124,"d":"1.24E-03"},{"v":0.000663,"d":"6.63E-04"},true,{"v":0.416,"d":"4.16E-01"}]
["Interleukin-13","IL-13",{"v":0.00112,"d":"1.12E-03"},{"v":0.00373,"d":"3.73E-03"},false,{"v":0.102,"d":"1.02E-01"}]
["Interleukin-10","IL-10",{"v":0.00124,"d":"1.24E-03"},{"v":0.000915,"d":"9.15E-04"},true,{"v":0.673,"d":"6.73E-01"}]
["Interleukin-8 (CXCL8)","IL-8",{"v":0.00112,"d":"1.12E-03"},{"v":0.00159,"d":"1.59E-03"},false,{"v":0.707,"d":"7.07E-01"}]
["Interleukin-6","IL-6",{"v":0.00112,"d":"1.12E-03"},{"v":0.00104,"d":"1.04E-03"},true,{"v":0.916,"d":"9.16E-01"}]
["Interleukin-1 receptor antagonist","IL1ra",{"v":0.00112,"d":"1.12E-03"},{"v":0.00221,"d":"2.21E-03"},false,{"v":0.418,"d":"4.18E-01"}]
["Interleukin-1-beta","IL-1b",{"v":0.00124,"d":"1.24E-03"},{"v":0.00271,"d":"2.71E-03"},false,{"v":0.335,"d":"3.35E-01"}]
["Hepatocyte growth factor","HGF",{"v":0.00112,"d":"1.12E-03"},{"v":0.00101,"d":"1.01E-03"},true,{"v":0.886,"d":"8.86E-01"}]
["Interleukin-9","IL-9",{"v":0.00112,"d":"1.12E-03"},{"v":0.00256,"d":"2.56E-03"},false,{"v":0.306,"d":"3.06E-01"}]
["Interleukin-7","IL-7",{"v":0.00112,"d":"1.12E-03"},{"v":0.00242,"d":"2.42E-03"},false,{"v":0.363,"d":"3.63E-01"}]
["Interleukin-5","IL-5",{"v":0.00112,"d":"1.12E-03"},{"v":0.00253,"d":"2.53E-03"},false,{"v":0.332,"d":"3.32E-01"}]
["Interleukin-4","IL-4",{"v":0.00124,"d":"1.24E-03"},{"v":0.000279,"d":"2.79E-04"},true,{"v":0.103,"d":"1.03E-01"}]
["Interleukin-2 receptor, alpha subunit","IL2ra",{"v":0.00112,"d":"1.12E-03"},{"v":0.00357,"d":"3.57E-03"},false,{"v":0.114,"d":"1.14E-01"}]
["Interleukin-2","IL-2",{"v":0.00112,"d":"1.12E-03"},{"v":0.00194,"d":"1.94E-03"},false,{"v":0.537,"d":"5.37E-01"}]
["Interferon-gamma","IFNg",{"v":0.00124,"d":"1.24E-03"},{"v":0.000685,"d":"6.85E-04"},true,{"v":0.439,"d":"4.39E-01"}]
["Growth regulated oncogene-α (CXCL1)","GROa",{"v":0.00112,"d":"1.12E-03"},{"v":0.00703,"d":"7.03E-03"},false,{"v":0.00305,"d":"3.05E-03"}]
["Granulocyte colony-stimulating factor","GCSF",{"v":0.00124,"d":"1.24E-03"},{"v":0.00131,"d":"1.31E-03"},false,{"v":0.927,"d":"9.27E-01"}]
["Basic fibroblast growth factor","bFGF",{"v":0.00124,"d":"1.24E-03"},{"v":0.000867,"d":"8.67E-04"},true,{"v":0.625,"d":"6.25E-01"}]
["Eotaxin (CCL11)","Eotaxin",{"v":0.00124,"d":"1.24E-03"},{"v":0.000428,"d":"4.28E-04"},true,{"v":0.201,"d":"2.01E-01"}]
["MR, Mendelian randomization; POI, primary ovarian insufficiency."]

{"sheet":"Sheet14","index":13,"n_rows":43,"n_cols":3,"rows_kept":43,"merged":[[0,0,0,2]],"flags":["formulas_cached_only"]}
["Table S14 Cytokine analyzed in this study and corresponding GWAS ID"]
["Cytokines","Abbreviation","GWAS ID"]
["Cutaneous T-cell attracting (CCL27)","CTACK","ebi-a-GCST004420"]
["Beta nerve growth factor","bNGF","ebi-a-GCST004421"]
["Vascular endothelial growth factor","VEGF","ebi-a-GCST004422"]
["Macrophage migration inhibitory factor (glycosylation-inhibiting factor)","MIF","ebi-a-GCST004423"]
["TNF-related apoptosis inducing ligand","TRAIL","ebi-a-GCST004424"]
["Tumor necrosis factor-beta","TNFb","ebi-a-GCST004425"]
["Tumor necrosis factor-alpha","TNFa","ebi-a-GCST004426"]
["Stromal cell-derived factor-1 alpha (CXCL12)","SDF1a","ebi-a-GCST004427"]
["Stem cell growth factor beta","SCGFb","ebi-a-GCST004428"]
["Stem cell factor","SCF","ebi-a-GCST004429"]
["Interleukin-16","IL-16","ebi-a-GCST004430"]
["Regulated on Activation, Normal T Cell Expressed and Secreted (CCL5)","RANTES","ebi-a-GCST004431"]
["Platelet derived growth factor BB","PDGFbb","ebi-a-GCST004432"]
["Macrophage inflammatory protein-1β (CCL4)","MIP1b","ebi-a-GCST004433"]
["Macrophage inflammatory protein-1α (CCL3)","MIP1a","ebi-a-GCST004434"]
["Monokine induced by interferon-gamma (CXCL9)","MIG","ebi-a-GCST004435"]
["Macrophage colony-stimulating factor","MCSF","ebi-a-GCST004436"]
["Monocyte specific chemokine 3 (CCL7)","MCP3","ebi-a-GCST004437"]
["Monocyte chemotactic protein-1 (CCL2)","MCP1","ebi-a-GCST004438"]
["Interleukin-12p70","IL-12p70","ebi-a-GCST004439"]
["Interferon gamma-induced protein 10 (CXCL10)","IP10","ebi-a-GCST004440"]
["Interleukin-18","IL-18","ebi-a-GCST004441"]
["Interleukin-17","IL-17","ebi-a-GCST004442"]
["Interleukin-13","IL-13","ebi-a-GCST004443"]
["Interleukin-10","IL-10","ebi-a-GCST004444"]
["Interleukin-8 (CXCL8)","IL-8","ebi-a-GCST004445"]
["Interleukin-6","IL-6","ebi-a-GCST004446"]
["Interleukin-1 receptor antagonist","IL1ra","ebi-a-GCST004447"]
["Interleukin-1-beta","IL-1b","ebi-a-GCST004448"]
["Hepatocyte growth factor","HGF","ebi-a-GCST004449"]
["Interleukin-9","IL-9","ebi-a-GCST004450"]
["Interleukin-7","IL-7","ebi-a-GCST004451"]
["Interleukin-5","IL-5","ebi-a-GCST004452"]
["Interleukin-4","IL-4","ebi-a-GCST004453"]
["Interleukin-2 receptor, alpha subunit","IL2ra","ebi-a-GCST004454"]
["Interleukin-2","IL-2","ebi-a-GCST004455"]
["Interferon-gamma","IFNg","ebi-a-GCST004456"]
["Growth regulated oncogene-α (CXCL1)","GROa","ebi-a-GCST004457"]
["Granulocyte colony-stimulating factor","GCSF","ebi-a-GCST004458"]
["Basic fibroblast growth factor","bFGF","ebi-a-GCST004459"]
["Eotaxin (CCL11)","Eotaxin","ebi-a-GCST004460"]