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["Supplementary 4.GO and KEGG analysis_data"]
["Term","L-c-vs-L-ins (18)"," All (16792) ","PValue"]
["GO:0043401~steroid hormone mediated signaling pathway",10,57,{"v":7.32e-19,"d":"7.32E-19"}]
["GO:0006367~transcription initiation from RNA polymerase II promoter",10,152,{"v":7.29e-15,"d":"7.29E-15"}]
["GO:0045944~positive regulation of transcription from RNA polymerase II promoter",12,981,{"v":2.29e-10,"d":"2.29E-10"}]
["GO:0006351~transcription, DNA-templated",14,1955,{"v":1.05e-09,"d":"1.05E-09"}]
["GO:0000122~negative regulation of transcription from RNA polymerase II promoter",10,720,{"v":8.32e-09,"d":"8.32E-09"}]
["GO:0044255~cellular lipid metabolic process",5,41,{"v":7.11e-08,"d":"7.11E-08"}]
["GO:0048384~retinoic acid receptor signaling pathway",4,18,{"v":6.97e-07,"d":"6.97E-07"}]
["GO:0030522~intracellular receptor signaling pathway",4,38,{"v":7.11e-06,"d":"7.11E-06"}]
["GO:0045893~positive regulation of transcription, DNA-templated",7,515,{"v":7.5e-06,"d":"7.50E-06"}]
["GO:0055012~ventricular cardiac muscle cell differentiation",3,6,{"v":1.44e-05,"d":"1.44E-05"}]
["GO:0045892~negative regulation of transcription, DNA-templated",6,499,{"v":0.000105,"d":"1.05E-04"}]
["GO:0008285~negative regulation of cell proliferation",5,396,{"v":0.000568,"d":"5.68E-04"}]
["GO:0007165~signal transduction",7,1161,{"v":0.000688,"d":"6.88E-04"}]
["GO:0038183~bile acid signaling pathway",2,2,0.002023809]
["GO:0035264~multicellular organism growth",3,80,0.002910174]
["GO:0002068~glandular epithelial cell development",2,3,0.003034267]
["GO:0003417~growth plate cartilage development",2,5,0.005052296]
["GO:0010887~negative regulation of cholesterol storage",2,6,0.006059868]
["GO:0035357~peroxisome proliferator activated receptor signaling pathway",2,7,0.00706648]
["GO:2000188~regulation of cholesterol homeostasis",2,9,0.009076825]
["GO:0010745~negative regulation of macrophage derived foam cell differentiation",2,13,0.013086029]
["GO:0031641~regulation of myelination",2,13,0.013086029]
["GO:0003148~outflow tract septum morphogenesis",2,23,0.02304235]
["GO:0015721~bile acid and bile salt transport",2,27,0.026998345]
["GO:0035116~embryonic hindlimb morphogenesis",2,28,0.027984986]
["GO:0043065~positive regulation of apoptotic process",3,300,0.036258782]
["GO:0001657~ureteric bud development",2,38,0.037799738]
["GO:0030521~androgen receptor signaling pathway",2,41,0.040725926]
["GO:0032526~response to retinoic acid",2,41,0.040725926]
["GO:0016575~histone deacetylation",2,46,0.045584302]
["GO:0030593~neutrophil chemotaxis",2,66,0.064787187]
["GO:0045444~fat cell differentiation",2,73,0.071421852]
["GO:0045666~positive regulation of neuron differentiation",2,78,0.076133748]
["GO:0043066~negative regulation of apoptotic process",3,455,0.076224071]
["GO:0050728~negative regulation of inflammatory response",2,79,0.077073423]
["GO:0060070~canonical Wnt signaling pathway",2,83,0.080823135]
["GO:0006874~cellular calcium ion homeostasis",2,93,0.090134782]

{"sheet":"GO-enriched analysis-CC","index":1,"n_rows":7,"n_cols":4,"rows_kept":7,"flags":["formulas_cached_only"]}
["Term","L-c-vs-L-ins (18)"," All (18224) ","PValue"]
["GO:0005654~nucleoplasm",13,2784,{"v":4.6e-07,"d":"4.60E-07"}]
["GO:0005634~nucleus",15,5415,{"v":1.06e-05,"d":"1.06E-05"}]
["GO:0017053~transcriptional repressor complex",3,55,0.001181424]
["GO:0090575~RNA polymerase II transcription factor complex",2,33,0.030354786]
["GO:0000118~histone deacetylase complex",2,36,0.033070878]
["GO:0005876~spindle microtubule",2,44,0.040278823]

{"sheet":"GO-enriched analysis-MF","index":2,"n_rows":27,"n_cols":4,"rows_kept":27,"flags":["formulas_cached_only"]}
["Term","L-c-vs-L-ins (17)"," All (16881) ","PValue"]
["GO:0003707~steroid hormone receptor activity",10,56,{"v":2.78e-19,"d":"2.78E-19"}]
["GO:0004879~RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding",6,36,{"v":1.42e-10,"d":"1.42E-10"}]
["GO:0043565~sequence-specific DNA binding",10,518,{"v":2.13e-10,"d":"2.13E-10"}]
["GO:0008270~zinc ion binding",10,1169,{"v":2.61e-07,"d":"2.61E-07"}]
["GO:0046965~retinoid X receptor binding",4,15,{"v":3.16e-07,"d":"3.16E-07"}]
["GO:0003700~transcription factor activity, sequence-specific DNA binding",9,961,{"v":9.15e-07,"d":"9.15E-07"}]
["GO:0003708~retinoic acid receptor activity",3,5,{"v":8.41e-06,"d":"8.41E-06"}]
["GO:0004887~thyroid hormone receptor activity",3,8,{"v":2.35e-05,"d":"2.35E-05"}]
["GO:0019904~protein domain specific binding",5,208,{"v":3.63e-05,"d":"3.63E-05"}]
["GO:0003713~transcription coactivator activity",5,248,{"v":7.2e-05,"d":"7.20E-05"}]
["GO:0003677~DNA binding",8,1674,{"v":0.000475,"d":"4.75E-04"}]
["GO:0003714~transcription corepressor activity",4,203,{"v":0.000855,"d":"8.55E-04"}]
["GO:0000977~RNA polymerase II regulatory region sequence-specific DNA binding",4,208,{"v":0.000917,"d":"9.17E-04"}]
["GO:0044212~transcription regulatory region DNA binding",4,213,{"v":0.000982,"d":"9.82E-04"}]
["GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding",4,236,0.001320502]
["GO:0031490~chromatin DNA binding",3,58,0.001349805]
["GO:0008134~transcription factor binding",4,284,0.002242993]
["GO:0008144~drug binding",3,76,0.002304232]
["GO:0008013~beta-catenin binding",3,82,0.002676158]
["GO:0070644~vitamin D response element binding",2,3,0.002840907]
["GO:0044323~retinoic acid-responsive element binding",2,4,0.003786194]
["GO:0001190~transcriptional activator activity, RNA polymerase II transcription factor binding",2,16,0.015064299]
["GO:0032403~protein complex binding",3,206,0.015891237]
["GO:0019899~enzyme binding",3,333,0.038800198]
["GO:0000980~RNA polymerase II distal enhancer sequence-specific DNA binding",2,65,0.059885999]
["GO:0046982~protein heterodimerization activity",3,465,0.070448592]

{"sheet":"KEGG-enriched analysis","index":3,"n_rows":4,"n_cols":4,"rows_kept":4,"flags":["formulas_cached_only"]}
["Term","L-c-vs-L-ins (16)"," All (6879) ","PValue"]
["hsa05200:Pathways in cancer",5,393,0.008653904]
["hsa05202:Transcriptional misregulation in cancer",3,167,0.050010764]
["hsa05216:Thyroid cancer",2,29,0.061464236]