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["Application of the Composite Quality Score (CQS-2B) in systematic reviews of prospective, controlled, clinical therapy trials – a pilot study "]
["Steffen Mickenautsch, Stefan Rupf, Veerasamy Yengopal"]
[]
["1. Systematic review:"]
["Sellem L, Flourakis M, Jackson KG, Joris PJ, Lumley J, Lohner S, Mensink RP, Soedamah-Muthu SS, Lovegrove JA. Impact of Replacement of Individual Dietary SFAs on Circulating Lipids and Other Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Humans. Adv Nutr. 2022 Aug 1;13(4):1200-1225. doi: 10.1093/advances/nmab143. PMID: 34849532; PMCID: PMC9340975."]
[]
["Trials = 34","Ref","CQS-2","RoB-2","Overall","L = Low eisk","SC = Some concerns",null,"H = High risk",null,"(Data extracted from Table 2)"]
["van Rooijen",16,"C1","L","van Rooijen MA, Plat J, Blom WAM, Zock PL, Mensink RP. Dietary stearic acid and palmitic acid do not differently affect ABCA1-mediated cholesterol efflux capacity in healthy men and postmenopausal women:a randomized controlled trial. Clin Nutr 2021;40(3):804–11."]
["Stonehouse",26,"C1","L","Stonehouse W, Sergi D, Benassi-Evans B, James-Martin G, Johnson N, Thompson CH, Abeywardena M. Eucaloric diets enriched in palm olein, cocoa butter, and soybean oil did not differentially affect liver fat concentration in healthy participants: a 16-week randomized controlled trial. Am J Clin Nutr 2021;113(2):324–37."]
["Sun",27,"C1","SC","Sun G, Xia H, Yang Y, Ma S, Zhou H, Shu G, Wang S, Yang X, Tang H, Wang F, et al. Effects of palm olein and olive oil on serum lipids in a Chinese population: a randomized, double-blind, cross-over trial. Asia Pac J Clin Nutr 2018;27(3):572–80."]
["Ng",28,"C1","L","Ng YT, Voon PT, Ng TKW, Lee VKM,Mat Sahri M,Mohd Esa N, Ong SH, Ong ASH. Interesterified palm olein (IEPalm) and interesterified stearic acid-rich fat blend (IEStear) have no adverse effects on insulin resistance: a randomized control trial. Nutrients 2018;10(8):1112."]
["Karupaiah",29,"C1","L","Karupaiah T, Chuah K-A, Chinna K,Matsuoka R,Masuda Y, Sundram K, Sugano M. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trialwith crossover design. Lipids Health Dis 2016;15(1):131."]
["Kien",30,"C1","H","Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM. Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. Am J Clin Nutr 2014;99(3):436–45."]
["Rosqvist",31,"C1","L","Rosqvist F, Iggman D, Kullberg J, Cedernaes J, Johansson H-E, Larsson A, Johansson L, Ahlström H, Arner P, Dahlman I, et al.Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans. Diabetes 2014;63(7): 2356–68."]
["Tholstrup",32,"C1","H","Tholstrup T, Hjerpsted J, Raff M. Palm olein increases plasma cholesterol moderately compared with olive oil in healthy individuals.Am J Clin Nutr 2011;94(6):1426–32."]
["Voon",33,"C1","SC","Voon PT, Ng TKW, Lee VKM, Nesaretnam K. Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults. Am J Clin Nutr 2011;94(6):1451–7."]
["Teng",34,"C1","H","Teng KT, Voon PT, Cheng HM, Nesaretnam K. Effects of partially hydrogenated, semi-saturated, and high oleate vegetable oils on inflammatory markers and lipids. Lipids 2010;45(5):385–92."]
["Utarwuthipong",35,"C1","SC","Utarwuthipong T, Komindr S, Pakpeankitvatana V, Songchitsomboon S, Thongmuang N. Small dense low-density lipoprotein concentration and oxidative susceptibility changes after consumption of soybean oil, rice bran oil, palm oil and mixed rice bran/palm oil in hypercholesterolaemic women. J Int Med Res 2009;37(1):96–104."]
["Mensink",36,"C1","L","Mensink RP. Effects of products made froma high-palmitic acid, transfree semiliquid fat or a high-oleic acid, low-trans semiliquid fat on the serum lipoprotein profile and on C-reactive protein concentrations in humans. Eur J Clin Nutr 2008;62(5):617–24."]
["Vega-López",37,"C1","L","Vega-López S, Ausman LM, Jalbert SM, Erkkilä AT, Lichtenstein AH.Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects. Am J Clin Nutr 2006;84(1):54–62."]
["Thijssen",38,"C1","H","Thijssen MA,Mensink RP. Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. Am J Clin Nutr 2005;82(3):510–16."]
["Gill",40,"C1","SC","Gill JMR, Brown JC, Caslake MJ, Wright DM, Cooney J, Bedford D, HughesDA, Stanley JC, PackardCJ. Effects of dietarymonounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL. Am J Clin Nutr 2003;78(1):47–56."]
["Cater",41,"C1","H","Cater NB, Denke MA. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr 2001;73(1):41–4."]
["Hunter",42,"C1","SC","Hunter KA, Crosbie LC,Weir A,Miller GJ,Dutta-Roy AK. A residential study comparing the effects of diets rich in stearic acid, oleic acid, and linoleic acid on fasting blood lipids, hemostatic variables and platelets in young healthy men. J Nutr Biochem 2000;11(7–8):408–16."]
["Snook",43,"C1","SC","Snook JT, Park S, Williams G, Tsai Y-H, Lee N. Effect of synthetic triglycerides ofmyristic, palmitic, and stearic acid on serum lipoprotein metabolism. Eur J Clin Nutr 1999;53(8):597–605."]
["Müller",44,"C1","H","Müller H, Jordal O, Kierulf P, Kirkhus B, Pedersen JI. Replacement of partially hydrogenated soybean oil by palm oil in margarine without unfavorable effects on serum lipoproteins. Lipids 1998;33(9):879–87."]
["Schwab",45,"C1","SC","Schwab US, Vogel S, Lammi-Keefe CJ, Ordovas JM, Schaefer EJ, Li Z, Ausman LM, Gualtieri L, Goldin BR, Furr HC, et al. Varying dietary fat type of reduced-fat diets has little effect on the susceptibility of LDL to oxidative modification in moderately hypercholesterolemic subjects. J Nutr 1998;128(10):1703–9."]
["Cater",46,"C1","H","Cater NB, Heller HJ, Denke MA. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am J Clin Nutr 1997;65(1):41–5."]
["Sundram",47,"C1","L","Sundram K, Ismail A, Hayes KC, Jeyamalar R, Pathmanathan R. Trans (elaidic) fatty acids adversely affect the lipoprotein profile relative to specific saturated fatty acids in humans. J Nutr 1997;127(3):514S–20S."]
["Schwab",48,"C1","L","Schwab US, Maliranta HM, Sarkkinen ES, Savolainen MJ, Kesäniemi YA, Uusitupa MI. Different effects of palmitic and stearic acidenriched diets on serum lipids and lipoproteins and plasma cholesteryl ester transfer protein activity in healthy young women. Metabolism 1996;45(2):143–9."]
["Temme",49,"C1","SC","Temme EH, Mensink RP, Hornstra G. Comparison of the effects of diets enriched in lauric, palmitic, or oleic acids on serum lipids and lipoproteins in healthy women and men. Am J Clin Nutr 1996;63(6):897–903."]
["Choudhury",50,"C1","L","Choudhury N, Tan L, Truswell AS. Comparison of palmolein and olive oil: effects on plasma lipids and vitamin E in young adults. Am J Clin Nutr 1995;61(5):1043–51."]
["Sundram",51,"C1","H","Sundram K, Hayes KC, Siru OH. Both dietary 18:2 and 16:0 may be required to improve the serum LDL/HDL cholesterol ratio in normocholesterolemic men. J Nutr Biochem 1995;6(4):179–87."]
["Nestel",52,"C1","H","Nestel P, Clifton P, Noakes M. Effects of increasing dietary palmitoleic acid compared with palmitic and oleic acids on plasma lipids of hypercholesterolemic men. J Lipid Res 1994;35(4):656–62."]
["Zock",53,"C1","H","Zock PL, deVries JH, KatanMB. Impact ofmyristic acid versus palmitic acid on serum lipid and lipoprotein levels in healthy women and men.Arterioscler Thromb 1994;14(4):567–75."]
["Denke",54,"C1","H","Denke MA, Grundy SM. Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. Am J Clin Nutr 1992;56(5):895–8."]
["Ng",55,"C1","SC","Ng TK, Hassan K, Lim JB, Lye MS, Ishak R. Nonhypercholesterolemic effects of a palm-oil diet in Malaysian volunteers. Am J Clin Nutr 1991;53(4):1015S–20S."]
["Bonanome",56,"C1","H","Bonanome A, Grundy SM. Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. N Engl J Med 1988;318(19):1244–8."]
["Mattson",57,"C1","SC","Mattson FH, Grundy SM. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J Lipid Res 1985;26(2):194–202."]
["Baudet",58,"C1","SC","Baudet MF, Dachet C, Lasserre M, Esteva O, Jacotot B. Modification in the composition and metabolic properties of human low density and high density lipoproteins by different dietary fats. J Lipid Res 1984;25(5):456–68."]
["Lv",67,"C1","SC","Lv C,Wang Y, Zhou C, Ma W, Yang Y, Xiao R, Yu H. Effects of dietary palm olein on the cardiovascular risk factors in healthy young adults.Food Nutr Res 2018;62:1353."]
[]
["2. Data stratification according to RoB2 appraisal results"]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on LDL-C"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"H",16,1.45,0.39,16,1.74,0.37,null,"Bonanome",56,"H",11,2.84,0.5,11,3.62,0.6,null,"Tholstrup",32,"H",32,2.11,0.28,32,2.32,0.28]
["Teng",34,null,"H",41,2.69,0.32,41,2.95,0.32,null,"van Rooijen",16,"L",34,3.44,1.14,34,3.58,1.22,null,"Sundram",51,"H",23,2.44,0.05,23,2.41,0.46]
["Cater",41,null,"H",7,3.7,0.59,7,4.42,0.72,null,"Ng",28,"L",28,3.39,0.7,28,3.2,0.57,null,"Nestel",52,"H",34,3.89,0.6,34,4.05,0.64]
["Müller",44,null,"H",27,2.61,0.65,27,2.9,0.75,null,"Schwab",48,"L",12,2.56,0.52,12,2.78,0.42,null,"Zock",53,"H",59,2.6,0.71,59,2.98,0.72]
["Cater",46,null,"H",9,3.72,0.47,9,4.37,0.7,null,"Snook",43,"SC",18,2.2,0.64,16,2.55,0.8,null,"Mensink",36,"L",44,3.49,1.13,44,3.84,1.14]
["Sundram",51,null,"H",23,2.44,0.05,23,2.56,0.49,{"$nulls":11},"Sundram",47,"L",27,3.17,0.7,27,3.15,0.73]
["Denke",54,null,"H",14,3.31,1.65,14,3.93,1.91,{"$nulls":11},"Choudhury",50,"L",21,3.41,0.96,21,3.33,1.13]
["Bonanome",56,null,"H",11,3.07,0.66,11,3.62,0.6,{"$nulls":11},"Voon",33,"SC",45,3.06,0.64,45,3.2,0.71]
["Stonehouse",26,null,"L",23,2.46,0.57,20,2.93,0.59,{"$nulls":11},"Temme",49,"SC",32,3.49,0.94,32,3.71,0.91]
["Karupaiah",29,null,"L",34,3.22,0.57,34,3.05,0.57]
["Vega-López",37,null,"L",15,3.62,0.59,15,4.27,0.91]
["Sun",27,null,"SC",100,2.51,0.5,100,2.48,0.5]
["Lv",67,null,"SC",29,2,0.43,28,2.24,0.58]
["Utarwuthipong",35,null,"SC",16,4.08,2.42,16,4.78,2.51]
["Gill",40,null,"SC",35,4,0.83,35,4.2,0.77]
["Schwab",45,null,"SC",14,3.24,0.51,14,3.16,0.44]
["Ng",55,null,"SC",26,1.78,0.49,27,2.52,0.77]
["Mattson",57,null,"SC",20,3.08,0.93,20,3.7,1.27]
[]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on TC"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"H",18,3.1,0.44,18,3.31,0.47,null,"Bonanome",56,"H",11,4.47,0.6,11,5.22,0.76,null,"Tholstrup",32,"H",32,3.92,0.45,32,4.15,0.57]
["Teng",34,null,"H",41,4.48,0.26,41,4.66,0.26,null,"van Rooijen",16,"L",34,5.39,1.22,34,5.58,1.29,null,"Sundram",51,"H",23,4.44,0.67,23,4.51,0.61]
["Cater",41,null,"H",7,5.12,0.54,7,5.84,0.72,null,"Ng",28,"L",28,5.3,0.7,28,5.19,0.57,null,"Nestel",52,"H",34,5.58,0.63,34,5.78,0.73]
["Müller",44,null,"H",27,4.45,0.64,27,4.74,0.66,null,"Schwab",48,"L",12,4.32,0.73,12,4.71,0.48,null,"Zock",53,"H",59,4.53,0.81,59,4.96,0.85]
["Cater",46,null,"H",9,5.22,0.52,9,5.79,0.72,null,"Snook",43,"SC",18,3.82,0.81,16,4.21,0.92,null,"Mensink",36,"L",44,5.6,1.15,44,6.03,1.16]
["Sundram",51,null,"H",23,4.44,0.67,23,4.54,0.62,{"$nulls":11},"Sundram",47,"L",27,4.78,0.7,27,4.85,0.77]
["Denke",54,null,"H",14,4.44,2.02,14,5.17,2.43,{"$nulls":11},"Choudhury",50,"L",21,4.63,0.99,21,4.65,1.26]
["Bonanome",56,null,"H",11,4.68,0.66,11,5.22,0.76,{"$nulls":11},"Voon",33,"SC",45,4.65,0.71,45,4.81,0.74]
["Stonehouse",26,null,"L",23,4.24,0.77,20,4.84,0.62,{"$nulls":11},"Temme",49,"SC",32,5.42,1.02,32,5.69,0.93]
["Karupaiah",29,null,"L",34,4.8,0.65,34,5.06,0.61]
["Vega-López",37,null,"L",15,5.43,0.65,15,6.21,0.93]
["Sun",27,null,"SC",100,4.36,0.68,100,4.34,0.69]
["Lv",67,null,"SC",29,3.96,0.59,28,4.3,2.96]
["Utarwuthipong",35,null,"SC",16,5.94,2.88,16,6.85,2.61]
["Gill",40,null,"SC",35,5.96,0.83,35,6.1,0.83]
["Schwab",45,null,"SC",14,5.05,0.53,14,5,0.49]
["Ng",55,null,"SC",26,3.15,0.6,27,4,0.87]
["Mattson",57,null,"SC",20,5.09,0.69,20,5.79,1.16]
["Baudet",58,null,"SC",24,4.53,0.59,24,5.11,0.87]
[]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on HDL-C"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"H",18,1.22,0.24,18,1.31,0.28,null,"Bonanome",56,"H",11,1.03,0.17,11,1.09,0.23,null,"Tholstrup",32,"H",32,1.2,0.11,32,1.22,0.11]
["Teng",34,null,"H",41,1.63,0.19,41,1.55,0.19,null,"van Rooijen",16,"L",34,1.39,0.27,34,1.48,0.29,null,"Sundram",51,"H",23,1.23,0.31,23,1.44,0.26]
["Cater",41,null,"H",7,0.91,0.16,7,0.88,0.16,null,"Ng",28,"L",28,1.39,0.24,28,1.36,0.27,null,"Nestel",52,"H",34,1.12,0.24,34,1.14,0.24]
["Müller",44,null,"H",27,1.43,0.28,27,1.47,0.32,null,"Schwab",48,"L",12,1.37,0.21,12,1.51,0.24,null,"Zock",53,"H",59,1.5,0.3,59,1.52,0.33]
["Cater",46,null,"H",9,0.93,0.26,9,0.91,0.16,null,"Snook",43,"SC",18,1.32,0.34,16,1.3,0.32,null,"Mensink",36,"L",44,1.55,0.39,44,1.62,0.43]
["Sundram",51,null,"H",23,1.23,0.31,23,1.23,0.28,{"$nulls":11},"Sundram",47,"L",27,1.25,0.19,27,1.26,0.22]
["Denke",54,null,"H",14,0.83,0.67,14,0.9,0.79,{"$nulls":11},"Choudhury",50,"L",21,0.8,0.19,21,0.91,0.33]
["Bonanome",56,null,"H",11,1.13,0.23,11,1.09,0.23,{"$nulls":11},"Voon",33,"SC",45,1.28,0.23,45,1.31,0.26]
["Stonehouse",26,null,"L",23,1.37,0.28,20,1.49,0.27,{"$nulls":11},"Temme",49,"SC",32,1.44,0.38,32,1.47,0.4]
["Karupaiah",29,null,"L",34,1.21,0.27,34,1.34,0.3]
["Vega-López",37,null,"L",15,1.24,0.21,15,1.29,0.21]
["Sun",27,null,"SC",100,1.22,0.2,100,1.21,0.17]
["Lv",67,null,"SC",29,1.45,0.32,28,1.44,0.26]
["Utarwuthipong",35,null,"SC",16,1.33,1.29,16,1.53,1.39]
["Gill",40,null,"SC",35,1.37,0.47,35,1.35,0.41]
["Schwab",45,null,"SC",14,1.14,0.24,14,1.15,0.24]
["Ng",55,null,"SC",26,0.99,0.21,27,1.08,0.27]
["Mattson",57,null,"SC",20,0.98,0.23,20,1.01,0.23]
[]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on triacylglycerol"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"H",18,0.53,0.16,18,0.58,0.18,null,"Bonanome",56,"H",11,1.46,0.36,11,1.45,0.5,null,"Tholstrup",32,"H",32,0.9,0.28,32,0.78,0.28]
["Teng",34,null,"H",41,0.83,0.06,41,0.88,0.06,null,"van Rooijen",16,"L",34,1.24,0.62,34,1.16,0.57,null,"Sundram",51,"H",23,0.94,0.34,23,0.73,0.25]
["Cater",41,null,"H",7,1.35,0.56,7,1.39,0.47,null,"Ng",28,"L",28,1.16,0.8,28,1.39,0.87,null,"Nestel",52,"H",34,1.27,0.53,34,1.3,0.58]
["Müller",44,null,"H",27,0.89,0.36,27,0.9,0.42,null,"Schwab",48,"L",12,0.84,0.42,12,1,0.52,null,"Zock",53,"H",59,0.95,0.43,59,1,0.55]
["Cater",46,null,"H",9,1.45,0.89,9,1.35,0.42,null,"Snook",43,"SC",18,0.64,0.42,16,0.8,0.52,null,"Mensink",36,"L",44,1.2,0.61,44,1.25,0.6]
["Sundram",51,null,"H",23,0.94,0.34,23,0.85,0.31,{"$nulls":11},"Sundram",47,"L",27,0.78,0.29,27,0.94,0.41]
["Denke",54,null,"H",14,1.05,0.75,14,1.06,0.71,{"$nulls":11},"Choudhury",50,"L",21,0.95,0.41,21,0.97,0.56]
["Bonanome",56,null,"H",11,1.38,0.43,11,1.45,0.5,{"$nulls":11},"Voon",33,"SC",45,0.84,0.37,45,0.85,0.31]
["Stonehouse",26,null,"L",23,0.88,0.48,20,0.92,0.35,{"$nulls":11},"Temme",49,"SC",32,1.07,0.42,32,1.11,0.54]
["Karupaiah",29,null,"L",34,1.13,0.54,34,1.08,0.45]
["Vega-López",37,null,"L",15,1.35,0.68,15,1.35,0.71]
["Sun",27,null,"SC",100,0.94,0.39,100,0.93,0.4]
["Lv",67,null,"SC",29,0.73,0.22,28,0.87,0.42]
["Utarwuthipong",35,null,"SC",16,1.16,1.68,16,1.17,1.54]
["Gill",40,null,"SC",35,1.76,0.71,35,1.79,0.77]
["Schwab",45,null,"SC",14,1.25,0.34,14,1.26,0.33]
["Ng",55,null,"SC",26,0.86,0.38,27,0.88,0.36]
["Mattson",57,null,"SC",20,2.81,1.92,20,2.92,1.97]
["Baudet",58,null,"SC",24,1.23,1.12,24,0.89,0.58]
[]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on apoA-I concentrations"]
[]
["Comparison:",{"$nulls":10},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Teng",34,null,"H",41,1.08,0.05,41,1.01,0.05,null,"Sundram",51,"H",23,1.31,0.2,23,1.33,0.17]
["Müller",44,null,"H",27,1.75,0.25,27,1.78,0.27,null,"Zock",53,"H",59,1.46,0.19,59,1.47,0.21]
["Sundram",51,null,"H",23,1.31,0.2,23,1.31,0.14,null,"Sundram",47,"L",27,1.35,0.23,27,1.31,0.24]
["Stonehouse",26,null,"L",23,1.41,0.22,20,1.53,0.2,null,"Voon",33,"SC",45,1.3,0.26,45,1.33,0.25]
["Karupaiah",29,null,"L",34,1.26,0.19,34,1.24,0.19,null,"Temme",49,"SC",32,1.67,0.3,32,1.74,0.37]
["Vega-López",37,null,"L",15,1.59,0.16,15,1.69,0.15]
["Sun",27,null,"SC",100,1.17,0.18,100,1.21,0.21]
["Lv",67,null,"SC",29,1.29,0.27,28,1.37,0.21]
["Gill",40,null,"SC",35,1.35,0.31,35,1.32,0.28]
[]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on apoB concentrations"]
[]
["Comparison:",{"$nulls":10},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Teng",34,null,"H",41,1.27,0.1,41,1.37,0.1,null,"Sundram",51,"H",23,0.86,0.24,23,0.89,0.18]
["Müller",44,null,"H",27,1.04,0.23,27,1.11,0.22,null,"Zock",53,"H",59,0.69,0.17,59,0.74,0.16]
["Sundram",51,null,"H",23,0.86,0.24,23,0.86,0.18,null,"Sundram",47,"L",27,0.84,0.25,27,0.88,0.15]
["Stonehouse",26,null,"L",23,0.71,0.14,20,0.79,0.15,null,"Voon",33,"SC",45,1.37,0.37,45,1.43,0.35]
["Karupaiah",29,null,"L",34,1.11,0.26,34,1.17,0.25,null,"Temme",49,"SC",32,1.12,0.32,32,1.18,0.3]
["Vega-López",37,null,"L",15,1.21,0.22,15,1.36,0.27]
["Sun",27,null,"SC",100,0.79,0.11,100,0.76,0.13]
["Lv",67,null,"SC",29,0.62,0.22,28,0.68,0.26]
["Gill",40,null,"SC",35,1.17,0.2,35,1.21,0.18]
[]
[]
[]
["2. Data stratification according to CQS-2B appraisal results"]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on LDL-C"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"C1",16,1.45,0.39,16,1.74,0.37,null,"Bonanome",56,"C1",11,2.84,0.5,11,3.62,0.6,null,"Tholstrup",32,"C1",32,2.11,0.28,32,2.32,0.28]
["Cater",41,null,"C1",7,3.7,0.59,7,4.42,0.72,null,"Ng",28,"C1",28,3.39,0.7,28,3.2,0.57,null,"Sundram",51,"C1",23,2.44,0.05,23,2.41,0.46]
["Müller",44,null,"C1",27,2.61,0.65,27,2.9,0.75,null,"Schwab",48,"C1",12,2.56,0.52,12,2.78,0.42,null,"Nestel",52,"C1",34,3.89,0.6,34,4.05,0.64]
["Cater",46,null,"C1",9,3.72,0.47,9,4.37,0.7,null,"Snook",43,"C1",18,2.2,0.64,16,2.55,0.8,null,"Zock",53,"C1",59,2.6,0.71,59,2.98,0.72]
["Sundram",51,null,"C1",23,2.44,0.05,23,2.56,0.49,{"$nulls":11},"Mensink",36,"C1",44,3.49,1.13,44,3.84,1.14]
["Denke",54,null,"C1",14,3.31,1.65,14,3.93,1.91,{"$nulls":11},"Sundram",47,"C1",27,3.17,0.7,27,3.15,0.73]
["Bonanome",56,null,"C1",11,3.07,0.66,11,3.62,0.6,null,"van Rooijen",16,"C3",34,3.44,1.14,34,3.58,1.22,null,"Choudhury",50,"C1",21,3.41,0.96,21,3.33,1.13]
["Karupaiah",29,null,"C1",34,3.22,0.57,34,3.05,0.57,{"$nulls":11},"Voon",33,"C1",45,3.06,0.64,45,3.2,0.71]
["Vega-López",37,null,"C1",15,3.62,0.59,15,4.27,0.91]
["Sun",27,null,"C1",100,2.51,0.5,100,2.48,0.5]
["Lv",67,null,"C1",29,2,0.43,28,2.24,0.58]
["Utarwuthipong",35,null,"C1",16,4.08,2.42,16,4.78,2.51]
["Gill",40,null,"C1",35,4,0.83,35,4.2,0.77]
["Schwab",45,null,"C1",14,3.24,0.51,14,3.16,0.44]
["Ng",55,null,"C1",26,1.78,0.49,27,2.52,0.77]
["Mattson",57,null,"C1",20,3.08,0.93,20,3.7,1.27]
[]
["Stonehouse",26,null,"C2",23,2.46,0.57,20,2.93,0.59]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on TC"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"C1",18,3.1,0.44,18,3.31,0.47,null,"Bonanome",56,"C1",11,4.47,0.6,11,5.22,0.76,null,"Tholstrup",32,"C1",32,3.92,0.45,32,4.15,0.57]
["Teng",34,null,"C1",41,4.48,0.26,41,4.66,0.26,null,"Ng",28,"C1",28,5.3,0.7,28,5.19,0.57,null,"Sundram",51,"C1",23,4.44,0.67,23,4.51,0.61]
["Cater",41,null,"C1",7,5.12,0.54,7,5.84,0.72,null,"Schwab",48,"C1",12,4.32,0.73,12,4.71,0.48,null,"Nestel",52,"C1",34,5.58,0.63,34,5.78,0.73]
["Müller",44,null,"C1",27,4.45,0.64,27,4.74,0.66,null,"Snook",43,"C1",18,3.82,0.81,16,4.21,0.92,null,"Zock",53,"C1",59,4.53,0.81,59,4.96,0.85]
["Cater",46,null,"C1",9,5.22,0.52,9,5.79,0.72,{"$nulls":11},"Mensink",36,"C1",44,5.6,1.15,44,6.03,1.16]
["Sundram",51,null,"C1",23,4.44,0.67,23,4.54,0.62,{"$nulls":11},"Sundram",47,"C1",27,4.78,0.7,27,4.85,0.77]
["Denke",54,null,"C1",14,4.44,2.02,14,5.17,2.43,null,"van Rooijen",16,"C3",34,5.39,1.22,34,5.58,1.29,null,"Choudhury",50,"C1",21,4.63,0.99,21,4.65,1.26]
["Bonanome",56,null,"C1",11,4.68,0.66,11,5.22,0.76,{"$nulls":11},"Voon",33,"C1",45,4.65,0.71,45,4.81,0.74]
["Karupaiah",29,null,"C1",34,4.8,0.65,34,5.06,0.61]
["Vega-López",37,null,"C1",15,5.43,0.65,15,6.21,0.93]
["Sun",27,null,"C1",100,4.36,0.68,100,4.34,0.69]
["Lv",67,null,"C1",29,3.96,0.59,28,4.3,2.96]
["Utarwuthipong",35,null,"C1",16,5.94,2.88,16,6.85,2.61]
["Gill",40,null,"C1",35,5.96,0.83,35,6.1,0.83]
["Schwab",45,null,"C1",14,5.05,0.53,14,5,0.49]
["Ng",55,null,"C1",26,3.15,0.6,27,4,0.87]
["Mattson",57,null,"C1",20,5.09,0.69,20,5.79,1.16]
["Baudet",58,null,"C1",24,4.53,0.59,24,5.11,0.87]
[]
["Stonehouse",26,null,"C2",23,4.24,0.77,20,4.84,0.62]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on HDL-C"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"C1",18,1.22,0.24,18,1.31,0.28,null,"Bonanome",56,"C1",11,1.03,0.17,11,1.09,0.23,null,"Tholstrup",32,"C1",32,1.2,0.11,32,1.22,0.11]
["Teng",34,null,"C1",41,1.63,0.19,41,1.55,0.19,null,"Ng",28,"C1",28,1.39,0.24,28,1.36,0.27,null,"Sundram",51,"C1",23,1.23,0.31,23,1.44,0.18]
["Cater",41,null,"C1",7,0.91,0.16,7,0.88,0.16,null,"Schwab",48,"C1",12,1.37,0.21,12,1.51,0.24,null,"Nestel",52,"C1",34,1.12,0.24,34,1.14,0.24]
["Müller",44,null,"C1",27,1.43,0.28,27,1.47,0.32,null,"Snook",43,"C1",18,1.32,0.34,16,1.3,0.32,null,"Zock",53,"C1",59,1.5,0.3,59,1.52,0.33]
["Cater",46,null,"C1",9,0.93,0.26,9,0.91,0.16,{"$nulls":11},"Mensink",36,"C1",44,1.55,0.39,44,1.62,0.43]
["Sundram",51,null,"C1",23,1.23,0.31,23,1.23,0.28,{"$nulls":11},"Sundram",47,"C1",27,1.25,0.19,27,1.26,0.22]
["Denke",54,null,"C1",14,0.83,0.67,14,0.9,0.79,null,"van Rooijen",16,"C3",34,1.39,0.27,34,1.48,0.29,null,"Choudhury",50,"C1",21,0.8,0.19,21,0.91,0.33]
["Bonanome",56,null,"C1",11,1.13,0.23,11,1.09,0.23,{"$nulls":11},"Voon",33,"C1",45,1.28,0.23,45,1.31,0.26]
["Karupaiah",29,null,"C1",34,1.21,0.27,34,1.34,0.3,{"$nulls":11},"Temme",49,"C1",32,1.44,0.38,32,1.47,0.4]
["Vega-López",37,null,"C1",15,1.24,0.21,15,1.29,0.21]
["Sun",27,null,"C1",100,1.22,0.2,100,1.21,0.17]
["Lv",67,null,"C1",29,1.45,0.32,28,1.44,0.26]
["Utarwuthipong",35,null,"C1",16,1.33,1.29,16,1.53,1.39]
["Gill",40,null,"C1",35,1.37,0.47,35,1.35,0.41]
["Schwab",45,null,"C1",14,1.14,0.24,14,1.15,0.24]
["Ng",55,null,"C1",26,0.99,0.21,27,1.08,0.27]
["Mattson",57,null,"C1",20,0.98,0.23,20,1.01,0.23]
[]
[]
["Stonehouse",26,null,"C2",23,1.37,0.28,20,1.49,0.27]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on triacylglycerol"]
[]
["Comparison:",{"$nulls":10},"Comparison:",{"$nulls":9},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Stearic acid",{"$nulls":9},"Palmitic acid vs Oleic acid"]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Stearic acid",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Kien",30,null,"C1",18,0.53,0.16,18,0.58,0.18,null,"Bonanome",56,"C1",11,1.46,0.36,11,1.45,0.5,null,"Tholstrup",32,"C1",32,0.9,0.28,32,0.78,0.28]
["Teng",34,null,"C1",41,0.83,0.06,41,0.88,0.06,null,"Ng",28,"C1",28,1.16,0.8,28,1.39,0.87,null,"Sundram",51,"C1",23,0.94,0.34,23,0.73,0.25]
["Cater",41,null,"C1",7,1.35,0.56,7,1.39,0.47,null,"Schwab",48,"C1",12,0.84,0.42,12,1,0.52,null,"Nestel",52,"C1",34,1.27,0.53,34,1.3,0.58]
["Müller",44,null,"C1",27,0.89,0.36,27,0.9,0.42,null,"Snook",43,"C1",18,0.64,0.42,16,0.8,0.52,null,"Zock",53,"C1",59,0.95,0.43,59,1,0.55]
["Cater",46,null,"C1",9,1.45,0.89,9,1.35,0.42,{"$nulls":11},"Mensink",36,"C1",44,1.2,0.61,44,1.25,0.6]
["Sundram",51,null,"C1",23,0.94,0.34,23,0.85,0.31,{"$nulls":11},"Sundram",47,"C1",27,0.78,0.29,27,0.94,0.41]
["Denke",54,null,"C1",14,1.05,0.75,14,1.06,0.71,null,"van Rooijen",16,"C3",34,1.24,0.62,34,1.16,0.57,null,"Choudhury",50,"C1",21,0.95,0.41,21,0.97,0.56]
["Bonanome",56,null,"C1",11,1.38,0.43,11,1.45,0.5,{"$nulls":11},"Voon",33,"C1",45,0.84,0.37,45,0.85,0.31]
["Karupaiah",29,null,"C1",34,1.13,0.54,34,1.08,0.45,{"$nulls":11},"Temme",49,"C1",32,1.07,0.42,32,1.11,0.54]
["Vega-López",37,null,"C1",15,1.35,0.68,15,1.35,0.71]
["Sun",27,null,"C1",100,0.94,0.39,100,0.93,0.4]
["Lv",67,null,"C1",29,0.73,0.22,28,0.87,0.42]
["Utarwuthipong",35,null,"C1",16,1.16,1.68,16,1.17,1.54]
["Gill",40,null,"C1",35,1.76,0.71,35,1.79,0.77]
["Schwab",45,null,"C1",14,1.25,0.34,14,1.26,0.33]
["Ng",55,null,"C1",26,0.86,0.38,27,0.88,0.36]
["Mattson",57,null,"C1",20,2.81,1.92,20,2.92," "]
["Baudet",58,null,"C1",24,1.23,1.12,24,0.89,0.58]
[]
[]
["Stonehouse",26,null,"C2",23,0.88,0.48,20,0.92,0.35]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on apoA-I concentrations"]
[]
["Comparison:",{"$nulls":10},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Teng",34,null,"C1",41,1.08,0.05,41,1.01,0.05,null,"Sundram",51,"C1",23,1.31,0.2,23,1.33,0.17]
["Müller",44,null,"C1",27,1.75,0.25,27,1.78,0.27,null,"Zock",53,"C1",59,1.46,0.19,59,1.47,0.21]
["Sundram",51,null,"C1",23,1.31,0.2,23,1.31,0.14,null,"Sundram",47,"C1",27,1.35,0.23,27,1.31,0.24]
["Karupaiah",29,null,"C1",34,1.26,0.19,34,1.24,0.19,null,"Voon",33,"C1",45,1.3,0.26,45,1.33,0.25]
["Vega-López",37,null,"C1",15,1.59,0.16,15,1.69,0.15,null,"Temme",49,"C1",32,1.67,0.3,32,1.74,0.37]
["Sun",27,null,"C1",100,1.17,0.18,100,1.21,0.21]
["Lv",67,null,"C1",29,1.29,0.27,28,1.37,0.21]
["Gill",40,null,"C1",35,1.35,0.31,35,1.32,0.28]
[]
[]
["Stonehouse",26,null,"C2",23,1.41,0.22,20,1.53,0.2]
[]
["Measured outcome:",null,null,"Effect of dietary fat substitutions on apoB concentrations"]
[]
["Comparison:",{"$nulls":10},"Comparison:"]
["Palmitic acid vs MUFAs+PUFAs",{"$nulls":10},"Palmitic acid vs Oleic acid"]
[]
[]
[{"$nulls":4},"Palmitic acid",null,null,"MUFAs+PUFAs",{"$nulls":6},"Palmitic acid",null,null,"Oleic acid"]
[{"$nulls":4},"N","Mean","SD","N","Mean","SD",{"$nulls":4},"N","Mean","SD","N","Mean","SD"]
["Teng",34,null,"C1",41,1.27,0.1,41,1.37,0.1,null,"Sundram",51,"C1",23,0.86,0.24,23,0.89,0.18]
["Müller",44,null,"C1",27,1.04,0.23,27,1.11,0.22,null,"Zock",53,"C1",59,0.69,0.17,59,0.74,0.16]
["Sundram",51,null,"C1",23,0.86,0.24,23,0.86,0.18,null,"Sundram",47,"C1",27,0.84,0.25,27,0.88,0.15]
["Karupaiah",29,null,"C1",34,1.11,0.26,34,1.17,0.25,null,"Voon",33,"C1",45,1.37,0.37,45,1.43,0.35]
["Vega-López",37,null,"C1",15,1.21,0.22,15,1.36,0.27,null,"Temme",49,"C1",32,1.12,0.32,32,1.18,0.3]
["Sun",27,null,"C1",100,0.79,0.11,100,0.76,0.13]
["Lv",67,null,"C1",29,0.62,0.22,28,0.68,0.26]
["Gill",40,null,"C1",35,1.17,0.2,35,1.21,0.18]
[]
[]
[]
["Stonehouse",26,null,"C1",23,0.71,0.14,20,0.79,0.15]

{"sheet":"Sheet2","index":1,"n_rows":214,"n_cols":14,"rows_kept":214,"flags":["formulas_cached_only"]}
["Risk of Bias 2 Tool",{"$nulls":12},"CQS-2"]
[]
["Comparison:",null,"Palmitic acid vs MUFAs+PUFAs"]
[]
["Measured outcome:",null,"Effect of dietary fat substitutions on LDL-C"]
{"$rows_empty":43}
["Measured outcome:",null,"Effect of dietary fat substitutions on TC"]
{"$rows_empty":43}
["Measured outcome:",null,"Effect of dietary fat substitutions on HDL-C"]
{"$rows_empty":42}
["Measured outcome:",null,"Effect of dietary fat substitutions on triacylglycerol"]
{"$rows_empty":43}
["Measured outcome:",null,"Effect of dietary fat substitutions on apoA-I concentrations"]
{"$rows_empty":33}
["Measured outcome:",null,"Effect of dietary fat substitutions on apoB concentrations"]

{"sheet":"Sheet3","index":2,"n_rows":98,"n_cols":14,"rows_kept":98,"flags":["formulas_cached_only"]}
["Risk of Bias 2 Tool",{"$nulls":12},"CQS-2"]
[]
["Comparison:",null,"Palmitic acid vs Stearic acid"]
[]
["Measured outcome:",null,"Effect of dietary fat substitutions on LDL-C"]
{"$rows_empty":30}
["Measured outcome:",null,"Effect of dietary fat substitutions on TC"]
{"$rows_empty":30}
["Measured outcome:",null,"Effect of dietary fat substitutions on HDL-C"]
{"$rows_empty":30}
["Measured outcome:",null,"Effect of dietary fat substitutions on triacylglycerol"]

{"sheet":"Sheet4","index":3,"n_rows":173,"n_cols":14,"rows_kept":173,"flags":["formulas_cached_only"]}
["Risk of Bias 2 Tool",{"$nulls":12},"CQS-2"]
[]
["Comparison:",null,"Palmitic acid vs Oleic acid"]
[]
["Measured outcome:",null,"Effect of dietary fat substitutions on LDL-C"]
{"$rows_empty":34}
["Measured outcome:",null,"Effect of dietary fat substitutions on TC"]
{"$rows_empty":34}
["Measured outcome:",null,"Effect of dietary fat substitutions on HDL-C"]
{"$rows_empty":33}
["Measured outcome:",null,"Effect of dietary fat substitutions on triacylglycerol"]
{"$rows_empty":33}
["Measured outcome:",null,"Effect of dietary fat substitutions on apoA-I concentrations"]
{"$rows_empty":29}
["Measured outcome:",null,"Effect of dietary fat substitutions on apoB concentrations"]

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["1. Meta-analyses"]
["1.1. RoB 2",{"$nulls":10},"1.2. CQS-2B"]
{"$rows_empty":30}
["2. WALD test"]
{"$rows_empty":9}
[null,"M","LCL","UCL",null,null,"SE","SE sq","M1-M2","denom","z","p-value"]
["ROB2",-0.07,-0.1,-0.04,0.03,0.030000000000000006,0.015306122448979591,0.000234277384423157,0.009999999999999995,0.02551020408163265,0.39199999999999985,0.695]
["CQS-2",-0.08,-0.12,-0.04,0.039999999999999994,0.04,0.02040816326530612,0.00041649312786339016]