Supplementary File S3: 112 LADEGs identified in TCGA-LUSC set 					
Gene	conMean	treatMean	logFC	pValue	fdr
ABCC1	10.11733061	43.92050558	2.118065966	2.13E-19	7.79E-19
ACADL	4.942993878	0.524999801	-3.234996339	1.07E-29	3.88E-28
ACOX2	3.631942857	0.838062151	-2.11561236	3.61E-28	5.17E-27
ACOXL	2.434330612	0.408660956	-2.574548799	3.48E-30	1.75E-28
ACSS3	1.756234694	0.406238645	-2.112086257	2.41E-27	2.61E-26
ADCY4	3.6692	0.72773008	-2.333990196	9.03E-29	1.64E-27
ADH1B	42.54409184	1.442844821	-4.881970746	1.09E-30	1.37E-28
ADH7	0.599357143	47.04214522	6.294394114	6.87E-15	1.79E-14
ADRB1	9.023110204	0.847999004	-3.411490331	1.72E-28	2.75E-27
ADRB2	20.62495918	2.866837849	-2.846859053	1.21E-29	4.05E-28
AGMO	0.076177551	0.574198008	2.914110512	0.000140966	0.000187798
AGRP	7.67097551	0.336078685	-4.512539103	1.98E-30	1.37E-28
AKR1B10	0.747879592	231.74476	8.275514987	1.04E-25	7.51E-25
AKR1B15	0.015208163	4.633132072	8.250998073	4.90E-27	5.03E-26
AKR1C1	3.186959184	79.06347948	4.632759	1.12E-08	1.87E-08
AKR1C2	1.727032653	93.88183944	5.764478844	1.01E-17	3.22E-17
AKR1C3	9.149355102	104.0236703	3.507097979	7.11E-06	1.02E-05
ALDH3A1	4.997979592	85.64910359	4.099021231	4.53E-08	7.41E-08
ALDH3B1	29.29628367	3.492040239	-3.068575577	1.17E-29	4.05E-28
ALDH3B2	0.568010204	16.22422908	4.836089271	6.01E-28	8.03E-27
ALOX12B	0.1481	0.93225239	2.654148951	2.06E-12	4.39E-12
ALOX15B	40.55637347	5.818843227	-2.801124371	4.97E-26	3.83E-25
ALOX5	50.37689796	8.448878088	-2.575930602	8.85E-29	1.64E-27
ALOX5AP	97.50067551	14.6852988	-2.731039593	2.23E-29	5.59E-28
ALOXE3	0.026830612	0.693783068	4.69253275	3.95E-25	2.66E-24
ANKRD1	53.9888898	1.216235458	-5.472168089	1.63E-29	4.68E-28
AOC3	77.71918163	6.862795219	-3.501402498	1.65E-30	1.37E-28
APOH	6.115195918	0.449678287	-3.765433592	4.55E-29	1.02E-27
B4GALNT1	0.116873469	2.288767928	4.291551811	9.67E-24	5.46E-23
BDH1	0.825240816	4.761606574	2.52856134	1.98E-25	1.38E-24
CA4	18.59273673	0.48112012	-5.2721982	1.23E-30	1.37E-28
CAV1	337.5873286	40.01922789	-3.076495515	5.30E-30	2.36E-28
CBR1	16.12524082	69.97004721	2.117416759	2.97E-13	6.89E-13
CBR3	0.944367347	6.438408566	2.769284066	2.39E-17	7.26E-17
CD36	18.44555102	2.610316135	-2.82097644	1.91E-28	3.00E-27
CEL	0.281202041	11.68901096	5.377401989	3.87E-21	1.65E-20
CERS3	0.025230612	6.123131873	7.922950729	4.41E-26	3.47E-25
CGA	0.005293878	0.61328745	6.856094794	0.001288985	0.001622867
CPNE7	0.46957551	2.603571713	2.47106307	2.61E-15	6.94E-15
CYP24A1	0.372536735	10.93689681	4.87567695	1.85E-16	5.28E-16
CYP27A1	67.31696327	14.73399024	-2.191821905	2.12E-28	3.26E-27
CYP27B1	0.48154898	3.245635857	2.752746695	3.82E-23	2.02E-22
CYP4B1	153.894802	7.00353247	-4.457717916	1.04E-29	3.88E-28
CYP4F11	0.538138776	31.11105956	5.853305456	4.48E-13	1.01E-12
CYP4F3	0.510793878	19.28016813	5.238232589	1.19E-07	1.88E-07
DGKA	2.275514286	9.677315936	2.088414319	3.32E-24	2.00E-23
DPEP2	5.263436735	0.817142231	-2.687345988	1.31E-29	4.18E-28
ELOVL2	0.282163265	1.66152012	2.557901681	2.50E-11	5.07E-11
ELOVL4	0.21395102	2.587058765	3.59596036	2.01E-22	9.89E-22
ENPP2	28.03642653	6.501302191	-2.108501858	1.19E-18	4.06E-18
ESYT3	3.719681633	0.577595817	-2.687046948	3.20E-29	7.78E-28
ETNK2	0.707842857	3.817963546	2.431302309	2.51E-25	1.72E-24
FABP3	19.18597959	4.340272112	-2.144195028	7.06E-19	2.48E-18
FABP4	97.19608367	11.06537191	-3.134846243	1.04E-27	1.28E-26
FABP7	0.028644898	7.056686853	7.944568982	8.60E-13	1.89E-12
FMO1	0.66145102	3.001269522	2.181866647	2.16E-11	4.40E-11
GPD1	16.99660612	0.545861952	-4.960566746	2.49E-30	1.53E-28
GPX2	1.592879592	224.1745592	7.136841535	6.76E-24	3.90E-23
GPX3	355.6623184	36.11748227	-3.2997389	1.90E-30	1.37E-28
GRHL1	0.797153061	6.081017928	2.931384175	1.15E-26	1.06E-25
HPGD	27.34063878	4.452446813	-2.618376667	7.79E-26	5.78E-25
HPGDS	3.761918367	0.637208765	-2.561630526	2.16E-29	5.59E-28
HSD17B1	0.110912245	1.311813745	3.564072341	1.96E-26	1.69E-25
HSD17B6	37.60742245	2.464018327	-3.931932538	2.05E-30	1.37E-28
INMT	70.83612653	2.67674004	-4.725936386	9.34E-31	1.37E-28
IRS4	0.025081633	1.215139243	5.59834657	0.009357245	0.010955489
LEPR	6.523522449	1.068384661	-2.610220006	1.96E-29	5.42E-28
LPL	54.70417959	4.253893825	-3.684795134	3.71E-30	1.75E-28
LRP2	2.218710204	0.430839243	-2.364499674	3.16E-26	2.59E-25
ME1	7.633381633	32.71911096	2.099739322	7.06E-10	1.31E-09
MGLL	27.79886122	6.209407371	-2.162498296	1.41E-29	4.18E-28
MMP1	2.062204082	112.7767311	5.773138508	4.45E-26	3.47E-25
NPR1	18.19870204	1.384759761	-3.716127946	9.86E-31	1.37E-28
OLR1	65.76171837	7.400633466	-3.151527327	6.94E-29	1.36E-27
PAFAH1B3	3.750430612	21.30900837	2.506335302	1.98E-30	1.37E-28
PIP5K1B	7.108808163	1.303649004	-2.447052214	5.62E-29	1.19E-27
PLA1A	9.652165306	1.550188645	-2.638408833	4.48E-27	4.66E-26
PLA2G1B	27.20658163	1.025112151	-4.730102041	1.61E-30	1.37E-28
PLA2G4F	14.62151429	2.582081873	-2.501486081	1.14E-27	1.39E-26
PLAAT1	0.207236735	4.305893825	4.376961083	2.96E-20	1.18E-19
PLD1	1.393738776	5.97415239	2.099773852	2.65E-23	1.43E-22
PLPP2	2.154104082	11.87505598	2.462774449	2.06E-25	1.42E-24
PLPP4	0.056614286	1.124649602	4.312165632	6.84E-27	6.77E-26
PNLIPRP3	0.012989796	0.804941235	5.953432793	0.017843587	0.020443652
POMC	0.678979592	5.315129084	2.968664613	8.43E-07	1.28E-06
PPP2R2C	0.049234694	4.851878884	6.622724439	2.26E-26	1.91E-25
PTGDS	2.2644	0.51194502	-2.145068043	6.51E-26	4.97E-25
PTGES	4.568673469	25.33286315	2.471162902	7.61E-19	2.67E-18
PTGIS	16.31224898	3.961623904	-2.041791871	5.21E-22	2.49E-21
PTGR1	7.102089796	40.69756673	2.518627033	3.53E-10	6.67E-10
RDH16	0.12422449	1.008893426	3.021752263	1.77E-21	8.13E-21
RXRG	2.499193878	0.323651793	-2.948948424	1.70E-28	2.75E-27
SELENOI	2.840938776	13.14494582	2.210068549	1.74E-30	1.37E-28
SGMS2	20.40213265	2.966411952	-2.781929099	4.59E-29	1.02E-27
SLC16A1	3.6168	24.35064462	2.751174237	2.83E-26	2.34E-25
SLC2A1	3.07377551	174.4820074	5.82692266	9.34E-31	1.37E-28
SLC44A5	0.243555102	3.086398207	3.6636041	1.30E-24	8.15E-24
SLC51B	5.210669388	0.496321912	-3.392120665	2.99E-30	1.71E-28
SLCO1B3	0.016040816	0.740018725	5.527742308	2.46E-14	6.12E-14
SORBS1	7.16422449	1.23263008	-2.539070642	9.78E-30	3.88E-28
SPNS2	14.10806531	2.897137052	-2.28382032	4.88E-28	6.75E-27
SPTSSB	0.067726531	3.137826693	5.533900769	3.05E-21	1.33E-20
SRD5A1	1.287385714	6.030441036	2.227819152	1.36E-29	4.18E-28
STAR	0.083965306	1.214048008	3.853888323	9.05E-18	2.88E-17
STARD5	0.137253061	0.583842231	2.088740242	2.87E-23	1.53E-22
UGT1A1	0.019308163	1.58381494	6.358049033	2.92E-20	1.17E-19
UGT1A10	0.008063265	2.886046016	8.483514395	1.86E-09	3.32E-09
UGT1A6	0.024	0.784917131	5.031434037	7.91E-19	2.76E-18
UGT1A7	0.011034694	5.04482988	8.836615203	2.40E-21	1.06E-20
UGT1A8	0.00265102	0.655783466	7.950527942	4.28E-09	7.28E-09
UGT2B17	0.138971429	0.665587251	2.259839493	0.00071814	0.000914204
UGT8	0.671834694	5.221951594	2.95841088	3.16E-14	7.79E-14