Supplementary File S4: KEGG pathways ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count hsa00590 Arachidonic acid metabolism 14/96 61/8191 4.98E-15 8.42E-13 6.66E-13 PLA2G1B/HPGDS/LTA4H/ALOX5/PLA2G4F/HPGD/ALOX15B/PTGIS/PLAAT3/PTGES/CBR3/PLA2G2A/CYP4F3/AKR1C3 14 hsa00565 Ether lipid metabolism Dec-96 50/8191 2.79E-13 2.36E-11 1.87E-11 PLA2G1B/PAFAH1B3/SELENOI/PLPP2/PLA2G4F/PLPP3/LPCAT1/PLD1/ENPP2/PLAAT3/UGT8/PLA2G2A 12 hsa00564 Glycerophospholipid metabolism 14/96 99/8191 5.88E-12 3.31E-10 2.62E-10 GPD1/PLA2G1B/GPD1L/PLA1A/SELENOI/PLPP2/PLA2G4F/PLPP3/DGKA/LPCAT1/ETNK2/PLD1/PLAAT3/PLA2G2A 14 hsa03320 PPAR signaling pathway Dec-96 75/8191 4.74E-11 2.00E-09 1.58E-09 ACADL/LPL/SORBS1/CD36/FABP4/OLR1/CYP27A1/PPARG/ACSL5/MMP1/FABP3/ACSL4 12 hsa04979 Cholesterol metabolism Aug-96 51/8191 1.12E-07 3.72E-06 2.94E-06 LPL/APOH/CD36/CYP27A1/NPC2/SORT1/LDLR/APOC1 8 hsa00600 Sphingolipid metabolism Aug-96 53/8191 1.52E-07 3.72E-06 2.94E-06 SGMS2/ASAH1/PLPP2/PLPP3/CERS6/CERS3/SPHK1/UGT8 8 hsa00350 Tyrosine metabolism Jul-96 36/8191 1.54E-07 3.72E-06 2.94E-06 ADH1B/ALDH3B1/AOC3/ALDH3B2/ADH7/MAOA/ALDH3A1 7 hsa00561 Glycerolipid metabolism Aug-96 62/8191 5.33E-07 1.13E-05 8.91E-06 LPL/ALDH2/PLPP2/MGLL/PLPP3/DGKA/AKR1B10/CEL 8 hsa00360 Phenylalanine metabolism May-96 16/8191 7.85E-07 1.47E-05 1.17E-05 ALDH3B1/AOC3/ALDH3B2/MAOA/ALDH3A1 5 hsa04920 Adipocytokine signaling pathway Aug-96 69/8191 1.23E-06 2.08E-05 1.65E-05 AGRP/SLC2A1/LEPR/CD36/ACSL5/ACSL4/SOCS3/TNFRSF1B 8 hsa00980 Metabolism of xenobiotics by cytochrome P450 Aug-96 78/8191 3.17E-06 4.87E-05 3.85E-05 ADH1B/HPGDS/ALDH3B1/ALDH3B2/ADH7/CBR3/AKR1C1/ALDH3A1 8 hsa00340 Histidine metabolism May-96 22/8191 4.48E-06 6.31E-05 4.99E-05 ALDH3B1/ALDH2/ALDH3B2/MAOA/ALDH3A1 5 hsa00071 Fatty acid degradation Jun-96 43/8191 9.51E-06 0.000114854 9.09E-05 ADH1B/ACADL/ALDH2/ACSL5/ACSL4/ADH7 6 hsa04975 Fat digestion and absorption Jun-96 43/8191 9.51E-06 0.000114854 9.09E-05 PLA2G1B/CD36/PLPP2/PLPP3/CEL/PLA2G2A 6 hsa00010 Glycolysis / Gluconeogenesis Jul-96 67/8191 1.19E-05 0.000134525 0.000106414 ADH1B/ALDH3B1/ALDH2/ALDH3B2/LDHA/ADH7/ALDH3A1 7 hsa05231 Choline metabolism in cancer Aug-96 98/8191 1.76E-05 0.000185528 0.000146758 PIP5K1B/PLPP2/PLA2G4F/PLPP3/DGKA/PLD1/SLC44A5/SLC44A4 8 hsa00982 Drug metabolism - cytochrome P450 Jul-96 72/8191 1.93E-05 0.000191711 0.000151649 ADH1B/HPGDS/ALDH3B1/ALDH3B2/ADH7/MAOA/ALDH3A1 7 hsa00410 beta-Alanine metabolism May-96 31/8191 2.66E-05 0.000249577 0.000197423 ALDH3B1/AOC3/ALDH2/ALDH3B2/ALDH3A1 5 hsa04923 Regulation of lipolysis in adipocytes Jun-96 58/8191 5.48E-05 0.000487776 0.000385846 NPR1/ADRB1/FABP4/ADRB2/MGLL/PLAAT3 6 hsa04071 Sphingolipid signaling pathway Aug-96 119/8191 7.16E-05 0.000604843 0.00047845 SGMS2/ASAH1/CERS6/PLD1/CERS3/PPP2R2C/SPHK1/ABCC1 8 hsa00140 Steroid hormone biosynthesis Jun-96 62/8191 8.02E-05 0.000645505 0.000510615 HSD17B6/HSD17B11/SRD5A1/AKR1C2/AKR1C1/AKR1C3 6 hsa00592 alpha-Linolenic acid metabolism Apr-96 26/8191 0.000217366 0.00166977 0.001320839 PLA2G1B/PLA2G4F/PLAAT3/PLA2G2A 4 hsa00591 Linoleic acid metabolism Apr-96 30/8191 0.000384414 0.002824611 0.002234354 PLA2G1B/PLA2G4F/PLAAT3/PLA2G2A 4 hsa04666 Fc gamma R-mediated phagocytosis Jun-96 97/8191 0.000928057 0.006535071 0.005169443 PIP5K1B/PLPP2/PLA2G4F/PLPP3/PLD1/SPHK1 6 hsa04072 Phospholipase D signaling pathway Jul-96 148/8191 0.001699338 0.011487526 0.009086988 PIP5K1B/PLPP2/PLA2G4F/PLPP3/DGKA/PLD1/SPHK1 7 hsa00620 Pyruvate metabolism Apr-96 47/8191 0.002149177 0.013969652 0.011050425 ADH1B/ALDH2/LDHA/ADH7 4 hsa04913 Ovarian steroidogenesis Apr-96 51/8191 0.00290569 0.018187467 0.014386847 ALOX5/PLA2G4F/LDLR/AKR1C3 4 hsa00790 Folate biosynthesis Mar-96 26/8191 0.003336165 0.020136139 0.015928307 PTS/AKR1B10/AKR1C3 3 GO terms ONTOLOGY ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count BP GO:0006631 fatty acid metabolic process 32/112 395/18800 1.35E-27 1.97E-24 1.53E-24 PLA2G1B/ACADL/LPL/HPGDS/CYP4B1/CD36/ASAH1/CAV1/ALOX5AP/ALOX5/PLA2G4F/MGLL/HPGD/ALOX15B/MFSD2A/PPARG/ACSL5/FABP3/ACSL4/PTGIS/AKR1C2/APOC1/LIPH/PTGES/ADH7/TRIB3/CEL/CYP4F11/CYP24A1/AKR1C1/CYP4F3/AKR1C3 32 BP GO:0016042 lipid catabolic process 30/112 327/18800 1.86E-27 1.97E-24 1.53E-24 PLA2G1B/HSD17B6/ACADL/LPL/ASAH1/PLA1A/PAFAH1B3/PLA2G4F/HSD17B11/MGLL/MFSD2A/CYP27A1/SRD5A1/TBL1XR1/PLD1/LDLR/AKR1B10/ENPP2/SPHK1/PLAAT3/PLAAT1/PLAAT4/APOC1/LIPH/CEL/CYP4F11/PLA2G2A/CYP24A1/CYP4F3/AKR1C3 30 BP GO:0046486 glycerolipid metabolic process 28/112 396/18800 1.72E-22 1.21E-19 9.44E-20 GPD1/PLA2G1B/LPL/APOH/PIP5K1B/PLA1A/CAV1/SELENOI/PLA2G4F/MGLL/MFSD2A/DGKA/LPCAT1/TBL1XR1/ETNK2/FABP3/PLD1/SLC44A5/LDLR/SLC44A4/ENPP2/PLAAT3/PLAAT1/PLAAT4/SOCS3/APOC1/LIPH/PLA2G2A 28 BP GO:0006644 phospholipid metabolic process 27/112 388/18800 1.66E-21 8.75E-19 6.81E-19 PLA2G1B/LPL/SGMS2/PIP5K1B/PLA1A/SELENOI/PLPP2/PLA2G4F/ALOX15B/MFSD2A/PLPP3/DGKA/LPCAT1/ETNK2/FABP3/PLD1/SLC44A5/LDLR/SLC44A4/ENPP2/PLAAT3/PLAAT1/PLAAT4/SOCS3/APOC1/LIPH/PLA2G2A 27 BP GO:0006690 icosanoid metabolic process 18/112 121/18800 1.66E-20 7.03E-18 5.47E-18 PLA2G1B/DPEP2/HPGDS/LTA4H/ALOX5AP/ALOX5/PLA2G4F/MGLL/HPGD/ALOX15B/PTGIS/AKR1C2/PTGES/ABCC1/CYP4F11/AKR1C1/CYP4F3/AKR1C3 18 BP GO:0006650 glycerophospholipid metabolic process 22/112 309/18800 8.26E-18 2.91E-15 2.26E-15 PLA2G1B/PIP5K1B/PLA1A/SELENOI/PLA2G4F/MFSD2A/DGKA/LPCAT1/ETNK2/FABP3/PLD1/SLC44A5/LDLR/SLC44A4/ENPP2/PLAAT3/PLAAT1/PLAAT4/SOCS3/APOC1/LIPH/PLA2G2A 22 BP GO:0010876 lipid localization 24/112 446/18800 1.37E-16 4.14E-14 3.22E-14 PLA2G1B/SLC51B/SLC2A1/LPL/APOH/ESYT3/CD36/FABP4/SPNS2/CAV1/PLA2G4F/MFSD2A/NPC2/PPARG/ACSL5/FABP3/LDLR/HILPDA/APOC1/PTGES/ABCC1/CEL/PLA2G2A/AKR1C1 24 BP GO:0006066 alcohol metabolic process 22/112 361/18800 2.22E-16 5.87E-14 4.57E-14 GPD1/ADH1B/ACADL/ALDH3B1/LEPR/ASAH1/ALDH2/PLPP2/ALDH3B2/PTS/PLPP3/CYP27A1/NPC2/LDLR/AKR1B10/SPHK1/AKR1C2/ADH7/CEL/AKR1B15/AKR1C1/AKR1C3 22 BP GO:0046470 phosphatidylcholine metabolic process 13/112 74/18800 4.50E-16 1.06E-13 8.22E-14 PLA2G1B/MFSD2A/LPCAT1/FABP3/SLC44A5/LDLR/SLC44A4/ENPP2/PLAAT3/PLAAT1/PLAAT4/APOC1/PLA2G2A 13 BP GO:0006869 lipid transport 22/112 391/18800 1.18E-15 2.49E-13 1.94E-13 PLA2G1B/SLC51B/SLC2A1/APOH/ESYT3/CD36/FABP4/SPNS2/CAV1/PLA2G4F/MFSD2A/NPC2/PPARG/ACSL5/FABP3/LDLR/APOC1/PTGES/ABCC1/CEL/PLA2G2A/AKR1C1 22 BP GO:1901616 organic hydroxy compound catabolic process 12/112 78/18800 3.42E-14 6.56E-12 5.11E-12 HSD17B6/ALDH3B1/ALDH2/ALDH3B2/CYP27A1/AKR1B10/MAOA/CEL/CYP4F11/CYP24A1/CYP4F3/AKR1C3 12 BP GO:0042180 cellular ketone metabolic process 16/112 211/18800 1.32E-13 2.32E-11 1.81E-11 GPD1/HSD17B6/ACADL/CAV1/MFSD2A/SRD5A1/PPARG/FABP3/AKR1B10/AKR1C2/APOC1/TRIB3/CYP4F11/AKR1C1/CYP4F3/AKR1C3 16 BP GO:0033559 unsaturated fatty acid metabolic process 13/112 115/18800 1.72E-13 2.79E-11 2.17E-11 HPGDS/ALOX5/PLA2G4F/MGLL/HPGD/ALOX15B/PTGIS/AKR1C2/PTGES/CYP4F11/AKR1C1/CYP4F3/AKR1C3 13 BP GO:0046394 carboxylic acid biosynthetic process 18/112 316/18800 4.82E-13 7.09E-11 5.51E-11 PLA2G1B/ACADL/LPL/HPGDS/LTA4H/ALOX5AP/ALOX5/PLA2G4F/MGLL/ALOX15B/CYP27A1/PTGIS/APOC1/LIPH/PTGES/TRIB3/CYP4F11/AKR1C3 18 BP GO:0120254 olefinic compound metabolic process 14/112 157/18800 5.30E-13 7.09E-11 5.51E-11 ADH1B/ALOX5/MGLL/ALOX15B/SRD5A1/PTGIS/AKR1B10/AKR1C2/ADH7/CYP4F11/AKR1B15/AKR1C1/CYP4F3/AKR1C3 14 BP GO:0016053 organic acid biosynthetic process 18/112 318/18800 5.37E-13 7.09E-11 5.51E-11 PLA2G1B/ACADL/LPL/HPGDS/LTA4H/ALOX5AP/ALOX5/PLA2G4F/MGLL/ALOX15B/CYP27A1/PTGIS/APOC1/LIPH/PTGES/TRIB3/CYP4F11/AKR1C3 18 BP GO:0006633 fatty acid biosynthetic process 14/112 162/18800 8.17E-13 1.02E-10 7.91E-11 PLA2G1B/ACADL/LPL/HPGDS/ALOX5/PLA2G4F/MGLL/ALOX15B/PTGIS/APOC1/LIPH/PTGES/TRIB3/AKR1C3 14 BP GO:0072330 monocarboxylic acid biosynthetic process 15/112 215/18800 2.71E-12 3.18E-10 2.47E-10 PLA2G1B/ACADL/LPL/HPGDS/ALOX5/PLA2G4F/MGLL/ALOX15B/CYP27A1/PTGIS/APOC1/LIPH/PTGES/TRIB3/AKR1C3 15 BP GO:0015909 long-chain fatty acid transport 10/112 66/18800 5.97E-12 6.64E-10 5.17E-10 PLA2G1B/SLC2A1/CD36/FABP4/PLA2G4F/MFSD2A/PPARG/ACSL5/FABP3/PLA2G2A 10 BP GO:0006665 sphingolipid metabolic process 13/112 161/18800 1.34E-11 1.41E-09 1.10E-09 ALDH3B1/SGMS2/ASAH1/SPNS2/PLPP2/ALDH3B2/PLPP3/CERS6/CERS3/ENPP2/SPHK1/UGT8/CEL 13 BP GO:0015908 fatty acid transport 11/112 99/18800 1.65E-11 1.66E-09 1.29E-09 PLA2G1B/SLC2A1/CD36/FABP4/PLA2G4F/MFSD2A/PPARG/ACSL5/FABP3/PTGES/PLA2G2A 11 BP GO:0006691 leukotriene metabolic process 8/112 34/18800 1.97E-11 1.89E-09 1.47E-09 PLA2G1B/DPEP2/LTA4H/ALOX5AP/ALOX5/ABCC1/CYP4F11/CYP4F3 8 BP GO:0034308 primary alcohol metabolic process 11/112 105/18800 3.17E-11 2.91E-09 2.27E-09 GPD1/ADH1B/ALDH3B1/ALDH2/ALDH3B2/AKR1B10/AKR1C2/ADH7/AKR1B15/AKR1C1/AKR1C3 11 BP GO:0046456 icosanoid biosynthetic process 9/112 57/18800 4.83E-11 4.15E-09 3.23E-09 PLA2G1B/HPGDS/LTA4H/ALOX5AP/ALOX5/PLA2G4F/PTGIS/PTGES/AKR1C3 9 BP GO:0044242 cellular lipid catabolic process 14/112 219/18800 4.91E-11 4.15E-09 3.23E-09 ACADL/LPL/ASAH1/PLA2G4F/MGLL/MFSD2A/LDLR/AKR1B10/ENPP2/SPHK1/APOC1/LIPH/CEL/AKR1C3 14 BP GO:0030148 sphingolipid biosynthetic process 11/112 110/18800 5.30E-11 4.30E-09 3.35E-09 ALDH3B1/SGMS2/ASAH1/SPNS2/PLPP2/ALDH3B2/PLPP3/CERS6/CERS3/SPHK1/UGT8 11 BP GO:0008202 steroid metabolic process 16/112 323/18800 8.55E-11 6.69E-09 5.21E-09 HSD17B6/ACADL/LEPR/ASAH1/HSD17B11/CYP27A1/SRD5A1/NPC2/LDLR/AKR1C2/APOC1/CEL/AKR1B15/CYP24A1/AKR1C1/AKR1C3 16 BP GO:0046337 phosphatidylethanolamine metabolic process 7/112 28/18800 2.35E-10 1.78E-08 1.38E-08 SELENOI/MFSD2A/ETNK2/PLAAT3/PLAAT1/PLAAT4/PLA2G2A 7 BP GO:0006643 membrane lipid metabolic process 13/112 207/18800 3.13E-10 2.28E-08 1.77E-08 ALDH3B1/SGMS2/ASAH1/SPNS2/PLPP2/ALDH3B2/PLPP3/CERS6/CERS3/ENPP2/SPHK1/UGT8/CEL 13 BP GO:0045017 glycerolipid biosynthetic process 14/112 253/18800 3.32E-10 2.34E-08 1.82E-08 LPL/PIP5K1B/SELENOI/MFSD2A/DGKA/LPCAT1/ETNK2/FABP3/PLD1/SLC44A5/LDLR/SLC44A4/SOCS3/LIPH 14 BP GO:0006639 acylglycerol metabolic process 11/112 131/18800 3.55E-10 2.42E-08 1.88E-08 LPL/APOH/CAV1/MGLL/MFSD2A/DGKA/TBL1XR1/LDLR/PLAAT3/APOC1/LIPH 11 BP GO:0006638 neutral lipid metabolic process 11/112 132/18800 3.86E-10 2.55E-08 1.98E-08 LPL/APOH/CAV1/MGLL/MFSD2A/DGKA/TBL1XR1/LDLR/PLAAT3/APOC1/LIPH 11 BP GO:0008654 phospholipid biosynthetic process 14/112 258/18800 4.29E-10 2.75E-08 2.14E-08 SGMS2/PIP5K1B/SELENOI/MFSD2A/DGKA/LPCAT1/ETNK2/FABP3/PLD1/SLC44A5/SLC44A4/PLAAT3/SOCS3/LIPH 14 BP GO:0006692 prostanoid metabolic process 8/112 50/18800 5.37E-10 3.24E-08 2.52E-08 HPGDS/PLA2G4F/HPGD/PTGIS/AKR1C2/PTGES/AKR1C1/AKR1C3 8 BP GO:0006693 prostaglandin metabolic process 8/112 50/18800 5.37E-10 3.24E-08 2.52E-08 HPGDS/PLA2G4F/HPGD/PTGIS/AKR1C2/PTGES/AKR1C1/AKR1C3 8 BP GO:0006641 triglyceride metabolic process 10/112 103/18800 5.56E-10 3.26E-08 2.54E-08 LPL/APOH/CAV1/MGLL/MFSD2A/TBL1XR1/LDLR/PLAAT3/APOC1/LIPH 10 BP GO:0015849 organic acid transport 15/112 318/18800 6.84E-10 3.91E-08 3.04E-08 PLA2G1B/SLC51B/SLC2A1/CD36/FABP4/SLC16A1/PLA2G4F/MFSD2A/PPARG/ACSL5/FABP3/PTGES/ABCC1/PLA2G2A/AKR1C1 15 BP GO:0001676 long-chain fatty acid metabolic process 10/112 111/18800 1.17E-09 6.49E-08 5.05E-08 ACADL/ALOX5/MGLL/ALOX15B/ACSL5/ACSL4/PTGIS/CYP4F11/CYP4F3/AKR1C3 10 BP GO:0046467 membrane lipid biosynthetic process 11/112 148/18800 1.31E-09 7.12E-08 5.54E-08 ALDH3B1/SGMS2/ASAH1/SPNS2/PLPP2/ALDH3B2/PLPP3/CERS6/CERS3/SPHK1/UGT8 11 BP GO:0019216 regulation of lipid metabolic process 15/112 339/18800 1.65E-09 8.69E-08 6.76E-08 ACADL/SORBS1/ASAH1/CAV1/MFSD2A/LPCAT1/TBL1XR1/NPC2/PPARG/FABP3/LDLR/SPHK1/APOC1/TRIB3/AKR1C3 15 BP GO:0150172 regulation of phosphatidylcholine metabolic process 5/112 10/18800 1.69E-09 8.70E-08 6.77E-08 MFSD2A/LPCAT1/FABP3/LDLR/APOC1 5 BP GO:0046474 glycerophospholipid biosynthetic process 12/112 214/18800 5.65E-09 2.84E-07 2.21E-07 PIP5K1B/SELENOI/MFSD2A/DGKA/LPCAT1/ETNK2/FABP3/PLD1/SLC44A5/SLC44A4/SOCS3/LIPH 12 BP GO:0030258 lipid modification 12/112 216/18800 6.28E-09 3.09E-07 2.40E-07 ACADL/ALOX5/PLPP2/ALOX15B/MFSD2A/PLPP3/DGKA/FABP3/SPHK1/APOC1/ADH7/CYP24A1 12 BP GO:0046890 regulation of lipid biosynthetic process 11/112 175/18800 7.72E-09 3.71E-07 2.88E-07 ACADL/SORBS1/ASAH1/MFSD2A/LPCAT1/FABP3/LDLR/SPHK1/APOC1/TRIB3/AKR1C3 11 BP GO:0034754 cellular hormone metabolic process 10/112 137/18800 9.13E-09 4.29E-07 3.34E-07 ADH1B/HSD17B6/HSD17B11/SRD5A1/AKR1B10/AKR1C2/ADH7/AKR1B15/AKR1C1/AKR1C3 10 BP GO:0006706 steroid catabolic process 6/112 27/18800 1.04E-08 4.80E-07 3.73E-07 HSD17B6/HSD17B11/CYP27A1/SRD5A1/CEL/CYP24A1 6 BP GO:0050727 regulation of inflammatory response 15/112 394/18800 1.25E-08 5.60E-07 4.36E-07 LPL/FABP4/ALOX5AP/ALOX5/MGLL/PPARG/TNFAIP8L2/PTGIS/LDLR/SPHK1/SOCS3/TNFRSF1B/PTGES/ABCC1/PLA2G2A 15 BP GO:0006672 ceramide metabolic process 9/112 105/18800 1.27E-08 5.60E-07 4.36E-07 SGMS2/ASAH1/PLPP2/PLPP3/CERS6/CERS3/SPHK1/UGT8/CEL 9 BP GO:0034310 primary alcohol catabolic process 5/112 15/18800 1.96E-08 8.47E-07 6.59E-07 ALDH3B1/ALDH2/ALDH3B2/AKR1B10/AKR1C3 5 BP GO:1901652 response to peptide 16/112 491/18800 3.49E-08 1.46E-06 1.14E-06 AGRP/PLA2G1B/SLC2A1/LPL/SORBS1/LTA4H/CD36/ADRB2/CAV1/SRD5A1/PPARG/SORT1/SOCS3/ABCC1/TRIB3/CA2 16 BP GO:0046164 alcohol catabolic process 7/112 55/18800 3.53E-08 1.46E-06 1.14E-06 ALDH3B1/ALDH2/ALDH3B2/CYP27A1/AKR1B10/CEL/AKR1C3 7 BP GO:0019369 arachidonic acid metabolic process 7/112 58/18800 5.16E-08 2.10E-06 1.63E-06 ALOX5/MGLL/ALOX15B/PTGIS/CYP4F11/CYP4F3/AKR1C3 7 BP GO:1901661 quinone metabolic process 6/112 38/18800 9.23E-08 3.68E-06 2.86E-06 AKR1B10/AKR1C2/CYP4F11/AKR1C1/CYP4F3/AKR1C3 6 BP GO:0120162 positive regulation of cold-induced thermogenesis 8/112 98/18800 1.24E-07 4.86E-06 3.78E-06 ACADL/LEPR/ADRB1/CD36/FABP4/ADRB2/CAV1/G0S2 8 BP GO:0006067 ethanol metabolic process 5/112 21/18800 1.29E-07 4.97E-06 3.87E-06 ADH1B/ALDH3B1/ALDH2/ALDH3B2/ADH7 5 BP GO:0046503 glycerolipid catabolic process 7/112 68/18800 1.58E-07 5.98E-06 4.65E-06 LPL/PLA2G4F/MGLL/LDLR/ENPP2/APOC1/LIPH 7 BP GO:0015711 organic anion transport 13/112 361/18800 2.38E-07 8.59E-06 6.68E-06 CA4/PLA2G1B/SLC51B/SLC2A1/CD36/SLC16A1/PLA2G4F/MFSD2A/SLC44A4/PTGES/ABCC1/PLA2G2A/AKR1C1 13 BP GO:0030638 polyketide metabolic process 4/112 10/18800 2.44E-07 8.59E-06 6.68E-06 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:0030647 aminoglycoside antibiotic metabolic process 4/112 10/18800 2.44E-07 8.59E-06 6.68E-06 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:0044598 doxorubicin metabolic process 4/112 10/18800 2.44E-07 8.59E-06 6.68E-06 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:1901568 fatty acid derivative metabolic process 7/112 74/18800 2.85E-07 9.89E-06 7.69E-06 ALOX5/HPGD/ALOX15B/ACSL5/ACSL4/CYP4F11/CYP4F3 7 BP GO:0044282 small molecule catabolic process 13/112 376/18800 3.79E-07 1.28E-05 9.95E-06 HSD17B6/ACADL/ALDH3B1/ALDH2/ALDH3B2/MFSD2A/CYP27A1/AKR1B10/CEL/CYP4F11/CYP24A1/CYP4F3/AKR1C3 13 BP GO:0019372 lipoxygenase pathway 4/112 11/18800 3.81E-07 1.28E-05 9.95E-06 ALOX5AP/ALOX5/HPGD/ALOX15B 4 BP GO:0030301 cholesterol transport 7/112 79/18800 4.49E-07 1.48E-05 1.15E-05 CD36/CAV1/NPC2/LDLR/APOC1/CEL/AKR1C1 7 BP GO:0006720 isoprenoid metabolic process 8/112 117/18800 4.90E-07 1.57E-05 1.22E-05 ADH1B/SRD5A1/NPC2/AKR1B10/ADH7/AKR1B15/AKR1C1/AKR1C3 8 BP GO:0015718 monocarboxylic acid transport 8/112 117/18800 4.90E-07 1.57E-05 1.22E-05 PLA2G1B/SLC51B/CD36/SLC16A1/PLA2G4F/PTGES/PLA2G2A/AKR1C1 8 BP GO:0006636 unsaturated fatty acid biosynthetic process 6/112 52/18800 6.36E-07 2.01E-05 1.56E-05 HPGDS/PLA2G4F/ALOX15B/PTGIS/PTGES/AKR1C3 6 BP GO:0006656 phosphatidylcholine biosynthetic process 5/112 29/18800 7.27E-07 2.26E-05 1.76E-05 MFSD2A/LPCAT1/FABP3/SLC44A5/SLC44A4 5 BP GO:0043434 response to peptide hormone 13/112 404/18800 8.52E-07 2.61E-05 2.03E-05 AGRP/PLA2G1B/SLC2A1/LPL/SORBS1/LTA4H/CAV1/SRD5A1/PPARG/SORT1/SOCS3/TRIB3/CA2 13 BP GO:0016101 diterpenoid metabolic process 7/112 87/18800 8.70E-07 2.63E-05 2.04E-05 ADH1B/SRD5A1/AKR1B10/ADH7/AKR1B15/AKR1C1/AKR1C3 7 BP GO:0062012 regulation of small molecule metabolic process 12/112 342/18800 9.38E-07 2.79E-05 2.17E-05 GPD1/ACADL/SORBS1/LEPR/CAV1/MFSD2A/PPARG/FABP3/LDLR/APOC1/TRIB3/AKR1C3 12 BP GO:0034311 diol metabolic process 5/112 31/18800 1.03E-06 3.02E-05 2.35E-05 ASAH1/PLPP2/PTS/PLPP3/SPHK1 5 BP GO:0001659 temperature homeostasis 9/112 177/18800 1.13E-06 3.28E-05 2.55E-05 ACADL/LEPR/ADRB1/CD36/FABP4/ADRB2/CAV1/PTGES/G0S2 9 BP GO:0042445 hormone metabolic process 10/112 230/18800 1.18E-06 3.33E-05 2.59E-05 ADH1B/HSD17B6/HSD17B11/SRD5A1/AKR1B10/AKR1C2/ADH7/AKR1B15/AKR1C1/AKR1C3 10 BP GO:0001516 prostaglandin biosynthetic process 5/112 32/18800 1.21E-06 3.33E-05 2.59E-05 HPGDS/PLA2G4F/PTGIS/PTGES/AKR1C3 5 BP GO:0010743 regulation of macrophage derived foam cell differentiation 5/112 32/18800 1.21E-06 3.33E-05 2.59E-05 LPL/CD36/ALOX15B/PPARG/PLA2G2A 5 BP GO:0046457 prostanoid biosynthetic process 5/112 32/18800 1.21E-06 3.33E-05 2.59E-05 HPGDS/PLA2G4F/PTGIS/PTGES/AKR1C3 5 BP GO:0010565 regulation of cellular ketone metabolic process 8/112 132/18800 1.23E-06 3.33E-05 2.59E-05 ACADL/CAV1/MFSD2A/PPARG/FABP3/APOC1/TRIB3/AKR1C3 8 BP GO:0019217 regulation of fatty acid metabolic process 7/112 92/18800 1.27E-06 3.40E-05 2.65E-05 ACADL/CAV1/MFSD2A/PPARG/FABP3/APOC1/TRIB3 7 BP GO:0015918 sterol transport 7/112 94/18800 1.47E-06 3.88E-05 3.02E-05 CD36/CAV1/NPC2/LDLR/APOC1/CEL/AKR1C1 7 BP GO:0010817 regulation of hormone levels 14/112 496/18800 1.49E-06 3.88E-05 3.02E-05 ADH1B/HSD17B6/ALOX5/SLC16A1/HSD17B11/SRD5A1/PPARG/ACSL4/AKR1B10/AKR1C2/ADH7/AKR1B15/AKR1C1/AKR1C3 14 BP GO:0045444 fat cell differentiation 10/112 237/18800 1.54E-06 3.97E-05 3.09E-05 LPL/ADRB1/FABP4/ADRB2/ALOX5/TBL1XR1/PPARG/SORT1/FABP3/TRIB3 10 BP GO:1901653 cellular response to peptide 12/112 361/18800 1.65E-06 4.18E-05 3.25E-05 PLA2G1B/LPL/SORBS1/CD36/ADRB2/CAV1/SRD5A1/PPARG/SOCS3/ABCC1/TRIB3/CA2 12 BP GO:0051055 negative regulation of lipid biosynthetic process 6/112 61/18800 1.66E-06 4.18E-05 3.25E-05 ACADL/LPCAT1/SPHK1/APOC1/TRIB3/AKR1C3 6 BP GO:0071398 cellular response to fatty acid 5/112 35/18800 1.93E-06 4.74E-05 3.69E-05 LPL/LDLR/AKR1C2/AKR1C1/AKR1C3 5 BP GO:0006721 terpenoid metabolic process 7/112 98/18800 1.95E-06 4.74E-05 3.69E-05 ADH1B/SRD5A1/AKR1B10/ADH7/AKR1B15/AKR1C1/AKR1C3 7 BP GO:0042632 cholesterol homeostasis 7/112 98/18800 1.95E-06 4.74E-05 3.69E-05 LPL/FABP4/CAV1/NPC2/FABP3/LDLR/AKR1C1 7 BP GO:0070542 response to fatty acid 6/112 63/18800 2.01E-06 4.83E-05 3.76E-05 LPL/CD36/LDLR/AKR1C2/AKR1C1/AKR1C3 6 BP GO:0042448 progesterone metabolic process 4/112 16/18800 2.06E-06 4.88E-05 3.80E-05 SRD5A1/AKR1C2/AKR1C1/AKR1C3 4 BP GO:0055092 sterol homeostasis 7/112 99/18800 2.09E-06 4.91E-05 3.82E-05 LPL/FABP4/CAV1/NPC2/FABP3/LDLR/AKR1C1 7 BP GO:0046473 phosphatidic acid metabolic process 5/112 37/18800 2.57E-06 5.89E-05 4.58E-05 DGKA/LPCAT1/PLD1/LIPH/PLA2G2A 5 BP GO:1903725 regulation of phospholipid metabolic process 5/112 37/18800 2.57E-06 5.89E-05 4.58E-05 MFSD2A/LPCAT1/FABP3/LDLR/APOC1 5 BP GO:0106106 cold-induced thermogenesis 8/112 146/18800 2.63E-06 5.89E-05 4.58E-05 ACADL/LEPR/ADRB1/CD36/FABP4/ADRB2/CAV1/G0S2 8 BP GO:0120161 regulation of cold-induced thermogenesis 8/112 146/18800 2.63E-06 5.89E-05 4.58E-05 ACADL/LEPR/ADRB1/CD36/FABP4/ADRB2/CAV1/G0S2 8 BP GO:0006081 cellular aldehyde metabolic process 6/112 66/18800 2.65E-06 5.89E-05 4.58E-05 ALDH3B1/ALDH2/ALDH3B2/AKR1C1/ALDH3A1/AKR1C3 6 BP GO:0044539 long-chain fatty acid import into cell 4/112 17/18800 2.68E-06 5.89E-05 4.58E-05 SLC2A1/CD36/ACSL5/FABP3 4 BP GO:0046513 ceramide biosynthetic process 6/112 67/18800 2.90E-06 6.32E-05 4.92E-05 SGMS2/ASAH1/CERS6/CERS3/SPHK1/UGT8 6 BP GO:0010742 macrophage derived foam cell differentiation 5/112 38/18800 2.94E-06 6.35E-05 4.94E-05 LPL/CD36/ALOX15B/PPARG/PLA2G2A 5 BP GO:0045833 negative regulation of lipid metabolic process 7/112 105/18800 3.10E-06 6.62E-05 5.15E-05 ACADL/MFSD2A/LPCAT1/SPHK1/APOC1/TRIB3/AKR1C3 7 BP GO:0090077 foam cell differentiation 5/112 39/18800 3.36E-06 7.03E-05 5.47E-05 LPL/CD36/ALOX15B/PPARG/PLA2G2A 5 BP GO:0032868 response to insulin 10/112 259/18800 3.42E-06 7.03E-05 5.47E-05 AGRP/PLA2G1B/SLC2A1/LPL/SORBS1/SRD5A1/PPARG/SORT1/SOCS3/TRIB3 10 BP GO:0030299 intestinal cholesterol absorption 4/112 18/18800 3.42E-06 7.03E-05 5.47E-05 CD36/LDLR/CEL/AKR1C1 4 BP GO:0140354 lipid import into cell 4/112 18/18800 3.42E-06 7.03E-05 5.47E-05 SLC2A1/CD36/ACSL5/FABP3 4 BP GO:0003018 vascular process in circulatory system 10/112 263/18800 3.91E-06 7.95E-05 6.19E-05 NPR1/SLC2A1/LEPR/ADRB1/CD36/ADRB2/CAV1/SLC16A1/MFSD2A/ABCC1 10 BP GO:0006766 vitamin metabolic process 7/112 109/18800 3.98E-06 8.02E-05 6.24E-05 SLC2A1/CYP27A1/ABCC1/CYP4F11/CYP24A1/CYP4F3/AKR1C3 7 BP GO:1905952 regulation of lipid localization 8/112 155/18800 4.10E-06 8.18E-05 6.36E-05 LPL/CD36/PPARG/ACSL5/FABP3/HILPDA/APOC1/PTGES 8 BP GO:0010744 positive regulation of macrophage derived foam cell differentiation 4/112 19/18800 4.32E-06 8.53E-05 6.64E-05 LPL/CD36/ALOX15B/PLA2G2A 4 BP GO:0034440 lipid oxidation 7/112 112/18800 4.77E-06 9.34E-05 7.27E-05 ACADL/ALOX5/ALOX15B/MFSD2A/FABP3/ADH7/CYP24A1 7 BP GO:1990845 adaptive thermogenesis 8/112 159/18800 4.95E-06 9.60E-05 7.47E-05 ACADL/LEPR/ADRB1/CD36/FABP4/ADRB2/CAV1/G0S2 8 BP GO:0006670 sphingosine metabolic process 4/112 21/18800 6.61E-06 0.000122448 9.53E-05 ASAH1/PLPP2/PLPP3/SPHK1 4 BP GO:0019370 leukotriene biosynthetic process 4/112 21/18800 6.61E-06 0.000122448 9.53E-05 PLA2G1B/LTA4H/ALOX5AP/ALOX5 4 BP GO:0044241 lipid digestion 4/112 21/18800 6.61E-06 0.000122448 9.53E-05 CD36/LDLR/CEL/AKR1C1 4 BP GO:0071404 cellular response to low-density lipoprotein particle stimulus 4/112 21/18800 6.61E-06 0.000122448 9.53E-05 LPL/CD36/PPARG/LDLR 4 BP GO:0098856 intestinal lipid absorption 4/112 21/18800 6.61E-06 0.000122448 9.53E-05 CD36/LDLR/CEL/AKR1C1 4 BP GO:0016137 glycoside metabolic process 4/112 22/18800 8.04E-06 0.000146404 0.000113923 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:1902644 tertiary alcohol metabolic process 4/112 22/18800 8.04E-06 0.000146404 0.000113923 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:0055088 lipid homeostasis 8/112 173/18800 9.22E-06 0.000166495 0.000129556 LPL/FABP4/CAV1/NPC2/PPARG/FABP3/LDLR/AKR1C1 8 BP GO:0046519 sphingoid metabolic process 4/112 23/18800 9.68E-06 0.000173423 0.000134948 ASAH1/PLPP2/PLPP3/SPHK1 4 BP GO:0001523 retinoid metabolic process 6/112 84/18800 1.09E-05 0.000191659 0.000149138 ADH1B/AKR1B10/ADH7/AKR1B15/AKR1C1/AKR1C3 6 BP GO:0097006 regulation of plasma lipoprotein particle levels 6/112 84/18800 1.09E-05 0.000191659 0.000149138 LPL/CD36/MFSD2A/LDLR/APOC1/PLA2G2A 6 BP GO:0042572 retinol metabolic process 5/112 51/18800 1.30E-05 0.000226168 0.00017599 ADH1B/AKR1B10/ADH7/AKR1B15/AKR1C3 5 BP GO:0010232 vascular transport 6/112 87/18800 1.33E-05 0.000228958 0.000178162 SLC2A1/LEPR/CD36/SLC16A1/MFSD2A/ABCC1 6 BP GO:0150104 transport across blood-brain barrier 6/112 87/18800 1.33E-05 0.000228958 0.000178162 SLC2A1/LEPR/CD36/SLC16A1/MFSD2A/ABCC1 6 BP GO:0031667 response to nutrient levels 12/112 446/18800 1.42E-05 0.000241964 0.000188282 SLC2A1/LPL/ADRB1/ADRB2/SLC16A1/MFSD2A/SRD5A1/TBL1XR1/PPARG/LDLR/CYP24A1/AKR1C3 12 BP GO:0009636 response to toxic substance 9/112 247/18800 1.71E-05 0.00028828 0.000224323 INMT/CD36/GPX3/ALOX5AP/CPOX/SRD5A1/GPX2/AKR1B10/PTGES 9 BP GO:0071715 icosanoid transport 5/112 54/18800 1.72E-05 0.00028828 0.000224323 PLA2G1B/PLA2G4F/PTGES/ABCC1/PLA2G2A 5 BP GO:0015850 organic hydroxy compound transport 9/112 248/18800 1.76E-05 0.000293598 0.000228461 SLC51B/CD36/CAV1/SLC16A1/NPC2/LDLR/APOC1/CEL/AKR1C1 9 BP GO:1905954 positive regulation of lipid localization 6/112 94/18800 2.08E-05 0.000342971 0.00026688 LPL/CD36/ACSL5/FABP3/HILPDA/PTGES 6 BP GO:0015911 long-chain fatty acid import across plasma membrane 3/112 10/18800 2.40E-05 0.000392446 0.000305378 SLC2A1/CD36/ACSL5 3 BP GO:0009991 response to extracellular stimulus 12/112 479/18800 2.87E-05 0.000466331 0.000362871 SLC2A1/LPL/ADRB1/ADRB2/SLC16A1/MFSD2A/SRD5A1/TBL1XR1/PPARG/LDLR/CYP24A1/AKR1C3 12 BP GO:0042447 hormone catabolic process 3/112 11/18800 3.28E-05 0.000527016 0.000410092 HSD17B6/HSD17B11/SRD5A1 3 BP GO:0062014 negative regulation of small molecule metabolic process 6/112 102/18800 3.31E-05 0.000527016 0.000410092 ACADL/LEPR/MFSD2A/APOC1/TRIB3/AKR1C3 6 BP GO:0030149 sphingolipid catabolic process 4/112 31/18800 3.32E-05 0.000527016 0.000410092 ASAH1/ENPP2/SPHK1/CEL 4 BP GO:0006654 phosphatidic acid biosynthetic process 4/112 33/18800 4.27E-05 0.000669058 0.000520621 DGKA/LPCAT1/PLD1/LIPH 4 BP GO:0055094 response to lipoprotein particle 4/112 33/18800 4.27E-05 0.000669058 0.000520621 LPL/CD36/PPARG/LDLR 4 BP GO:0006068 ethanol catabolic process 3/112 12/18800 4.35E-05 0.00067654 0.000526443 ALDH3B1/ALDH2/ALDH3B2 3 BP GO:0046942 carboxylic acid transport 9/112 279/18800 4.44E-05 0.00068537 0.000533314 PLA2G1B/SLC51B/CD36/SLC16A1/PLA2G4F/PTGES/ABCC1/PLA2G2A/AKR1C1 9 BP GO:0046475 glycerophospholipid catabolic process 4/112 34/18800 4.82E-05 0.000738387 0.000574569 PLA2G4F/LDLR/ENPP2/APOC1 4 BP GO:0045922 negative regulation of fatty acid metabolic process 4/112 35/18800 5.42E-05 0.000823878 0.000641093 ACADL/MFSD2A/APOC1/TRIB3 4 BP GO:0042363 fat-soluble vitamin catabolic process 3/112 13/18800 5.64E-05 0.000850666 0.000661938 CYP4F11/CYP24A1/CYP4F3 3 BP GO:0046466 membrane lipid catabolic process 4/112 36/18800 6.07E-05 0.00090313 0.000702762 ASAH1/ENPP2/SPHK1/CEL 4 BP GO:0071402 cellular response to lipoprotein particle stimulus 4/112 36/18800 6.07E-05 0.00090313 0.000702762 LPL/CD36/PPARG/LDLR 4 BP GO:1990748 cellular detoxification 6/112 115/18800 6.49E-05 0.000958822 0.000746098 CD36/GPX3/ALOX5AP/GPX2/AKR1B10/PTGES 6 BP GO:0071375 cellular response to peptide hormone stimulus 9/112 294/18800 6.66E-05 0.000976674 0.00075999 PLA2G1B/LPL/SORBS1/CAV1/SRD5A1/PPARG/SOCS3/TRIB3/CA2 9 BP GO:0008207 C21-steroid hormone metabolic process 4/112 37/18800 6.77E-05 0.000985589 0.000766927 SRD5A1/AKR1C2/AKR1C1/AKR1C3 4 BP GO:0019751 polyol metabolic process 6/112 116/18800 6.81E-05 0.000985589 0.000766927 ASAH1/PLPP2/PTS/PLPP3/CYP27A1/SPHK1 6 BP GO:0042182 ketone catabolic process 3/112 14/18800 7.14E-05 0.001026637 0.000798868 HSD17B6/CYP4F11/CYP4F3 3 BP GO:0006694 steroid biosynthetic process 7/112 175/18800 8.56E-05 0.001221931 0.000950834 HSD17B6/ASAH1/HSD17B11/CYP27A1/SRD5A1/AKR1B15/AKR1C3 7 BP GO:0009111 vitamin catabolic process 3/112 15/18800 8.89E-05 0.00126058 0.000980908 CYP4F11/CYP24A1/CYP4F3 3 BP GO:0097237 cellular response to toxic substance 6/112 123/18800 9.43E-05 0.001328335 0.001033631 CD36/GPX3/ALOX5AP/GPX2/AKR1B10/PTGES 6 BP GO:0050892 intestinal absorption 4/112 41/18800 0.00010198 0.001417657 0.001103136 CD36/LDLR/CEL/AKR1C1 4 BP GO:0120178 steroid hormone biosynthetic process 4/112 41/18800 0.00010198 0.001417657 0.001103136 HSD17B6/HSD17B11/SRD5A1/AKR1B15 4 BP GO:0031649 heat generation 3/112 16/18800 0.00010893 0.001481393 0.001152732 ADRB1/ADRB2/PTGES 3 BP GO:0034638 phosphatidylcholine catabolic process 3/112 16/18800 0.00010893 0.001481393 0.001152732 LDLR/ENPP2/APOC1 3 BP GO:0050872 white fat cell differentiation 3/112 16/18800 0.00010893 0.001481393 0.001152732 FABP4/TBL1XR1/PPARG 3 BP GO:0050728 negative regulation of inflammatory response 7/112 182/18800 0.000109369 0.001481393 0.001152732 ALOX5/PPARG/TNFAIP8L2/PTGIS/LDLR/SOCS3/TNFRSF1B 7 BP GO:0006775 fat-soluble vitamin metabolic process 4/112 43/18800 0.000123142 0.001657317 0.001289625 CYP27A1/CYP4F11/CYP24A1/CYP4F3 4 BP GO:1901569 fatty acid derivative catabolic process 3/112 17/18800 0.000131698 0.001761259 0.001370507 HPGD/CYP4F11/CYP4F3 3 BP GO:0071827 plasma lipoprotein particle organization 4/112 45/18800 0.000147316 0.001957725 0.001523385 LPL/MFSD2A/APOC1/PLA2G2A 4 BP GO:1902001 fatty acid transmembrane transport 3/112 18/18800 0.000157353 0.002078047 0.001617012 SLC2A1/CD36/ACSL5 3 BP GO:0032309 icosanoid secretion 4/112 46/18800 0.000160609 0.002107867 0.001640216 PLA2G1B/PLA2G4F/PTGES/PLA2G2A 4 BP GO:0019915 lipid storage 5/112 86/18800 0.000162736 0.002122595 0.001651677 LPL/CD36/CAV1/PPARG/HILPDA 5 BP GO:0008203 cholesterol metabolic process 6/112 139/18800 0.000184509 0.002391822 0.001861173 ACADL/LEPR/CYP27A1/NPC2/LDLR/CEL 6 BP GO:0010885 regulation of cholesterol storage 3/112 19/18800 0.000186047 0.002397062 0.001865251 LPL/CD36/PPARG 3 BP GO:0071825 protein-lipid complex subunit organization 4/112 48/18800 0.000189763 0.002430117 0.001890972 LPL/MFSD2A/APOC1/PLA2G2A 4 BP GO:0050873 brown fat cell differentiation 4/112 49/18800 0.000205687 0.002618179 0.00203731 ADRB1/FABP4/ADRB2/FABP3 4 BP GO:0051004 regulation of lipoprotein lipase activity 3/112 20/18800 0.000217931 0.002757417 0.002145658 APOH/SORT1/APOC1 3 BP GO:1901570 fatty acid derivative biosynthetic process 4/112 50/18800 0.000222553 0.00279913 0.002178116 ALOX5/ALOX15B/ACSL5/ACSL4 4 BP GO:0032869 cellular response to insulin stimulus 7/112 205/18800 0.000227943 0.002849958 0.002217667 PLA2G1B/LPL/SORBS1/SRD5A1/PPARG/SOCS3/TRIB3 7 BP GO:0015748 organophosphate ester transport 6/112 145/18800 0.000232063 0.002867544 0.002231352 MFSD2A/NPC2/LDLR/SLC44A4/APOC1/ABCC1 6 BP GO:0050729 positive regulation of inflammatory response 6/112 145/18800 0.000232063 0.002867544 0.002231352 LPL/FABP4/ALOX5AP/LDLR/ABCC1/PLA2G2A 6 BP GO:0010878 cholesterol storage 3/112 21/18800 0.000253152 0.003091967 0.002405984 LPL/CD36/PPARG 3 BP GO:0045717 negative regulation of fatty acid biosynthetic process 3/112 21/18800 0.000253152 0.003091967 0.002405984 ACADL/APOC1/TRIB3 3 BP GO:0009395 phospholipid catabolic process 4/112 52/18800 0.000259235 0.00314807 0.00244964 PLA2G4F/LDLR/ENPP2/APOC1 4 BP GO:1902652 secondary alcohol metabolic process 6/112 149/18800 0.000268788 0.003245419 0.002525392 ACADL/LEPR/CYP27A1/NPC2/LDLR/CEL 6 BP GO:0098754 detoxification 6/112 150/18800 0.000278646 0.003345333 0.002603139 CD36/GPX3/ALOX5AP/GPX2/AKR1B10/PTGES 6 BP GO:0035357 peroxisome proliferator activated receptor signaling pathway 3/112 22/18800 0.000291854 0.003484115 0.00271113 ALOX15B/PPARG/PTGIS 3 BP GO:0045834 positive regulation of lipid metabolic process 6/112 153/18800 0.000309935 0.00367917 0.002862911 SORBS1/MFSD2A/PPARG/FABP3/LDLR/APOC1 6 BP GO:0016125 sterol metabolic process 6/112 154/18800 0.000320955 0.003781461 0.002942508 ACADL/LEPR/CYP27A1/NPC2/LDLR/CEL 6 BP GO:0010883 regulation of lipid storage 4/112 55/18800 0.000322131 0.003781461 0.002942508 LPL/CD36/PPARG/HILPDA 4 BP GO:0098869 cellular oxidant detoxification 5/112 100/18800 0.000329331 0.003844618 0.002991652 CD36/GPX3/ALOX5AP/GPX2/PTGES 5 BP GO:0034312 diol biosynthetic process 3/112 23/18800 0.00033418 0.003879791 0.003019022 ASAH1/PTS/SPHK1 3 BP GO:0008643 carbohydrate transport 6/112 156/18800 0.000343917 0.003971019 0.00309001 PLA2G1B/SLC2A1/SORBS1/MFSD2A/SORT1/TRIB3 6 BP GO:0046434 organophosphate catabolic process 6/112 157/18800 0.00035587 0.004086706 0.003180031 GPD1/GPD1L/PLA2G4F/LDLR/ENPP2/APOC1 6 BP GO:0015914 phospholipid transport 5/112 102/18800 0.000360927 0.00412237 0.003207782 MFSD2A/NPC2/LDLR/APOC1/ABCC1 5 BP GO:0019218 regulation of steroid metabolic process 5/112 104/18800 0.000394764 0.004484605 0.003489652 ACADL/ASAH1/LDLR/APOC1/AKR1C3 5 BP GO:0019748 secondary metabolic process 4/112 59/18800 0.000422086 0.004769348 0.003711222 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:2000193 positive regulation of fatty acid transport 3/112 25/18800 0.000430252 0.004817917 0.003749015 ACSL5/FABP3/PTGES 3 BP GO:0019395 fatty acid oxidation 5/112 106/18800 0.000430945 0.004817917 0.003749015 ACADL/MFSD2A/FABP3/ADH7/CYP24A1 5 BP GO:0071356 cellular response to tumor necrosis factor 7/112 229/18800 0.000445145 0.004950484 0.003852172 GPD1/ANKRD1/ASAH1/FABP4/SPHK1/TNFRSF1B/TNFRSF21 7 BP GO:0009913 epidermal cell differentiation 7/112 230/18800 0.000456894 0.005054541 0.003933142 ASAH1/ALOX15B/GRHL1/CERS3/SLC44A4/PLAAT4/AKR1C3 7 BP GO:0030216 keratinocyte differentiation 6/112 167/18800 0.000494195 0.005438716 0.004232084 ASAH1/ALOX15B/GRHL1/CERS3/PLAAT4/AKR1C3 6 BP GO:0046173 polyol biosynthetic process 4/112 63/18800 0.000542423 0.005908195 0.004597405 ASAH1/PTS/CYP27A1/SPHK1 4 BP GO:0010884 positive regulation of lipid storage 3/112 27/18800 0.000542447 0.005908195 0.004597405 LPL/CD36/HILPDA 3 BP GO:1904659 glucose transmembrane transport 5/112 113/18800 0.000577546 0.006258231 0.004869782 PLA2G1B/SLC2A1/SORBS1/SORT1/TRIB3 5 BP GO:0042446 hormone biosynthetic process 4/112 65/18800 0.000610921 0.006586105 0.005124914 HSD17B6/HSD17B11/SRD5A1/AKR1B15 4 BP GO:1901617 organic hydroxy compound biosynthetic process 7/112 243/18800 0.000633455 0.00679437 0.005286973 ASAH1/ALDH2/ALOX15B/PTS/CYP27A1/SPHK1/AKR1C3 7 BP GO:0002021 response to dietary excess 3/112 29/18800 0.000671796 0.00713319 0.005550623 ADRB1/ADRB2/TBL1XR1 3 BP GO:0008209 androgen metabolic process 3/112 29/18800 0.000671796 0.00713319 0.005550623 HSD17B6/HSD17B11/SRD5A1 3 BP GO:0008645 hexose transmembrane transport 5/112 117/18800 0.000676554 0.00714779 0.005561983 PLA2G1B/SLC2A1/SORBS1/SORT1/TRIB3 5 BP GO:0032368 regulation of lipid transport 5/112 118/18800 0.000703175 0.007392088 0.005752082 PPARG/ACSL5/FABP3/APOC1/PTGES 5 BP GO:0015749 monosaccharide transmembrane transport 5/112 119/18800 0.000730573 0.007612849 0.005923865 PLA2G1B/SLC2A1/SORBS1/SORT1/TRIB3 5 BP GO:0034612 response to tumor necrosis factor 7/112 249/18800 0.000731381 0.007612849 0.005923865 GPD1/ANKRD1/ASAH1/FABP4/SPHK1/TNFRSF1B/TNFRSF21 7 BP GO:0006091 generation of precursor metabolites and energy 10/112 494/18800 0.000740546 0.007623365 0.005932048 GPD1/ADH1B/HSD17B6/SORBS1/LEPR/ALDH2/SRD5A1/GPX2/LDHA/ADH7 10 BP GO:0034368 protein-lipid complex remodeling 3/112 30/18800 0.000743215 0.007623365 0.005932048 LPL/APOC1/PLA2G2A 3 BP GO:0034369 plasma lipoprotein particle remodeling 3/112 30/18800 0.000743215 0.007623365 0.005932048 LPL/APOC1/PLA2G2A 3 BP GO:0033344 cholesterol efflux 4/112 69/18800 0.000765968 0.007818793 0.006084118 CAV1/NPC2/PPARG/APOC1 4 BP GO:0009308 amine metabolic process 5/112 121/18800 0.000787756 0.008002537 0.006227096 INMT/NPR1/AOC3/ALDH2/MAOA 5 BP GO:0019433 triglyceride catabolic process 3/112 31/18800 0.000819291 0.008204558 0.006384298 LPL/MGLL/LIPH 3 BP GO:0050482 arachidonic acid secretion 3/112 31/18800 0.000819291 0.008204558 0.006384298 PLA2G1B/PLA2G4F/PLA2G2A 3 BP GO:1903963 arachidonate transport 3/112 31/18800 0.000819291 0.008204558 0.006384298 PLA2G1B/PLA2G4F/PLA2G2A 3 BP GO:0062197 cellular response to chemical stress 8/112 332/18800 0.000841724 0.008389445 0.006528166 SLC2A1/ALDH3B1/CD36/CAV1/ALOX5/SPHK1/ABCC1/AKR1C3 8 BP GO:0072329 monocarboxylic acid catabolic process 5/112 124/18800 0.000879712 0.008726903 0.006790756 ACADL/MFSD2A/CEL/CYP4F11/CYP4F3 5 BP GO:0034367 protein-containing complex remodeling 3/112 32/18800 0.000900141 0.008846505 0.006883822 LPL/APOC1/PLA2G2A 3 BP GO:0046320 regulation of fatty acid oxidation 3/112 32/18800 0.000900141 0.008846505 0.006883822 ACADL/MFSD2A/FABP3 3 BP GO:2000191 regulation of fatty acid transport 3/112 33/18800 0.000985881 0.009644288 0.007504609 ACSL5/FABP3/PTGES 3 BP GO:0042573 retinoic acid metabolic process 3/112 34/18800 0.001076622 0.010435329 0.008120151 ADH1B/ADH7/AKR1C3 3 BP GO:1904893 negative regulation of receptor signaling pathway via STAT 3/112 34/18800 0.001076622 0.010435329 0.008120151 CAV1/PPARG/SOCS3 3 BP GO:0001937 negative regulation of endothelial cell proliferation 4/112 76/18800 0.001101046 0.010623338 0.008266447 APOH/CAV1/ALOX5/PPARG 4 BP GO:0031348 negative regulation of defense response 7/112 268/18800 0.001122845 0.010758043 0.008371267 ALOX5/PPARG/TNFAIP8L2/PTGIS/LDLR/SOCS3/TNFRSF1B 7 BP GO:0034219 carbohydrate transmembrane transport 5/112 131/18800 0.00112519 0.010758043 0.008371267 PLA2G1B/SLC2A1/SORBS1/SORT1/TRIB3 5 BP GO:0061041 regulation of wound healing 5/112 133/18800 0.001203816 0.011457947 0.008915891 APOH/CD36/CAV1/ALOX5/PLPP3 5 BP GO:0046323 glucose import 4/112 79/18800 0.001271944 0.011960003 0.009306561 PLA2G1B/SLC2A1/SORBS1/SORT1 4 BP GO:0045936 negative regulation of phosphate metabolic process 9/112 440/18800 0.001272857 0.011960003 0.009306561 FABP4/GPD1L/CAV1/PLPP3/LPCAT1/PPARG/SOCS3/APOC1/TRIB3 9 BP GO:0046471 phosphatidylglycerol metabolic process 3/112 36/18800 0.001273545 0.011960003 0.009306561 PLA2G1B/PLA2G4F/LPCAT1 3 BP GO:0010563 negative regulation of phosphorus metabolic process 9/112 441/18800 0.001293002 0.012088995 0.009406935 FABP4/GPD1L/CAV1/PLPP3/LPCAT1/PPARG/SOCS3/APOC1/TRIB3 9 BP GO:0007586 digestion 5/112 137/18800 0.00137318 0.012782069 0.009946244 CD36/LDLR/AKR1C2/CEL/AKR1C1 5 BP GO:0045616 regulation of keratinocyte differentiation 3/112 38/18800 0.001491761 0.013824958 0.010757758 ALOX15B/GRHL1/PLAAT4 3 BP GO:0006646 phosphatidylethanolamine biosynthetic process 2/112 10/18800 0.001534271 0.013973767 0.010873552 SELENOI/ETNK2 2 BP GO:0006702 androgen biosynthetic process 2/112 10/18800 0.001534271 0.013973767 0.010873552 HSD17B6/SRD5A1 2 BP GO:0034379 very-low-density lipoprotein particle assembly 2/112 10/18800 0.001534271 0.013973767 0.010873552 MFSD2A/APOC1 2 BP GO:0036152 phosphatidylethanolamine acyl-chain remodeling 2/112 10/18800 0.001534271 0.013973767 0.010873552 PLAAT3/PLAAT4 2 BP GO:0045598 regulation of fat cell differentiation 5/112 142/18800 0.001608873 0.01459034 0.011353332 LPL/ALOX5/PPARG/SORT1/TRIB3 5 BP GO:0035264 multicellular organism growth 5/112 143/18800 0.001659367 0.014983941 0.011659609 ADRB1/ADRB2/MFSD2A/TBL1XR1/ETNK2 5 BP GO:0046889 positive regulation of lipid biosynthetic process 4/112 85/18800 0.001667912 0.014997016 0.011669783 SORBS1/MFSD2A/FABP3/LDLR 4 BP GO:0019432 triglyceride biosynthetic process 3/112 40/18800 0.00173208 0.015442556 0.012016475 LPL/MFSD2A/LDLR 3 BP GO:0097009 energy homeostasis 3/112 40/18800 0.00173208 0.015442556 0.012016475 LEPR/CD36/MFSD2A 3 BP GO:0031669 cellular response to nutrient levels 6/112 213/18800 0.00174111 0.015457837 0.012028366 SLC2A1/LPL/MFSD2A/SRD5A1/CYP24A1/AKR1C3 6 BP GO:0046461 neutral lipid catabolic process 3/112 41/18800 0.001860772 0.01591507 0.012384158 LPL/MGLL/LIPH 3 BP GO:0046464 acylglycerol catabolic process 3/112 41/18800 0.001860772 0.01591507 0.012384158 LPL/MGLL/LIPH 3 BP GO:0150077 regulation of neuroinflammatory response 3/112 41/18800 0.001860772 0.01591507 0.012384158 LDLR/SPHK1/TNFRSF1B 3 BP GO:0006703 estrogen biosynthetic process 2/112 11/18800 0.001867931 0.01591507 0.012384158 HSD17B11/AKR1B15 2 BP GO:0006707 cholesterol catabolic process 2/112 11/18800 0.001867931 0.01591507 0.012384158 CYP27A1/CEL 2 BP GO:0008300 isoprenoid catabolic process 2/112 11/18800 0.001867931 0.01591507 0.012384158 AKR1B10/AKR1C3 2 BP GO:0016127 sterol catabolic process 2/112 11/18800 0.001867931 0.01591507 0.012384158 CYP27A1/CEL 2 BP GO:0040015 negative regulation of multicellular organism growth 2/112 11/18800 0.001867931 0.01591507 0.012384158 ADRB1/ADRB2 2 BP GO:0042428 serotonin metabolic process 2/112 11/18800 0.001867931 0.01591507 0.012384158 ALDH2/SRD5A1 2 BP GO:0052646 alditol phosphate metabolic process 2/112 11/18800 0.001867931 0.01591507 0.012384158 GPD1/GPD1L 2 BP GO:0042417 dopamine metabolic process 3/112 42/18800 0.001995278 0.01686409 0.013122629 NPR1/ALDH2/MAOA 3 BP GO:0090207 regulation of triglyceride metabolic process 3/112 42/18800 0.001995278 0.01686409 0.013122629 MFSD2A/TBL1XR1/LDLR 3 BP GO:0007584 response to nutrient 5/112 150/18800 0.002046056 0.017116301 0.013318884 LPL/SLC16A1/PPARG/CYP24A1/AKR1C3 5 BP GO:0050878 regulation of body fluid levels 8/112 382/18800 0.002047945 0.017116301 0.013318884 NPR1/APOH/CD36/CAV1/DGKA/GRHL1/CEL/CYP4F11 8 BP GO:0060191 regulation of lipase activity 4/112 90/18800 0.00205752 0.017116301 0.013318884 PLA2G1B/APOH/SORT1/APOC1 4 BP GO:1901657 glycosyl compound metabolic process 4/112 90/18800 0.00205752 0.017116301 0.013318884 AKR1B10/AKR1C2/AKR1C1/AKR1C3 4 BP GO:1905039 carboxylic acid transmembrane transport 5/112 152/18800 0.0021677 0.017962157 0.013977079 SLC2A1/CD36/SLC16A1/ACSL5/ABCC1 5 BP GO:1903825 organic acid transmembrane transport 5/112 153/18800 0.002230462 0.018286523 0.014229482 SLC2A1/CD36/SLC16A1/ACSL5/ABCC1 5 BP GO:0002024 diet induced thermogenesis 2/112 12/18800 0.002232808 0.018286523 0.014229482 ADRB1/ADRB2 2 BP GO:0046322 negative regulation of fatty acid oxidation 2/112 12/18800 0.002232808 0.018286523 0.014229482 ACADL/MFSD2A 2 BP GO:0032892 positive regulation of organic acid transport 3/112 45/18800 0.002434576 0.019709805 0.015336994 ACSL5/FABP3/PTGES 3 BP GO:0051180 vitamin transport 3/112 45/18800 0.002434576 0.019709805 0.015336994 SLC2A1/SLC44A4/ABCC1 3 BP GO:1904646 cellular response to amyloid-beta 3/112 45/18800 0.002434576 0.019709805 0.015336994 CD36/ADRB2/ABCC1 3 BP GO:0071496 cellular response to external stimulus 7/112 309/18800 0.00252042 0.020326903 0.015817183 ANKRD1/SLC2A1/LPL/MFSD2A/SRD5A1/CYP24A1/AKR1C3 7 BP GO:0046677 response to antibiotic 3/112 46/18800 0.002593225 0.02083454 0.016212196 AOC3/PLA2G4F/SRD5A1 3 BP GO:0046185 aldehyde catabolic process 2/112 13/18800 0.002628525 0.021038159 0.01637064 ALDH3B1/ALDH2 2 BP GO:0032365 intracellular lipid transport 3/112 47/18800 0.002758121 0.021992112 0.01711295 NPC2/FABP3/LDLR 3 BP GO:1901361 organic cyclic compound catabolic process 9/112 494/18800 0.002792245 0.022180499 0.017259541 HSD17B6/HSD17B11/CYP27A1/SRD5A1/TNFRSF1B/ABCC1/MAOA/CEL/CYP24A1 9 BP GO:0046460 neutral lipid biosynthetic process 3/112 48/18800 0.002929345 0.023095917 0.017971865 LPL/MFSD2A/LDLR 3 BP GO:0046463 acylglycerol biosynthetic process 3/112 48/18800 0.002929345 0.023095917 0.017971865 LPL/MFSD2A/LDLR 3 BP GO:0003376 sphingosine-1-phosphate receptor signaling pathway 2/112 14/18800 0.003054709 0.023643225 0.018397747 SPNS2/SPHK1 2 BP GO:0010867 positive regulation of triglyceride biosynthetic process 2/112 14/18800 0.003054709 0.023643225 0.018397747 MFSD2A/LDLR 2 BP GO:0035672 oligopeptide transmembrane transport 2/112 14/18800 0.003054709 0.023643225 0.018397747 ABCC1/CA2 2 BP GO:0038166 angiotensin-activated signaling pathway 2/112 14/18800 0.003054709 0.023643225 0.018397747 CAV1/CA2 2 BP GO:1901160 primary amino compound metabolic process 2/112 14/18800 0.003054709 0.023643225 0.018397747 ALDH2/SRD5A1 2 BP GO:0042304 regulation of fatty acid biosynthetic process 3/112 49/18800 0.003106975 0.023959991 0.018644236 ACADL/APOC1/TRIB3 3 BP GO:1903034 regulation of response to wounding 5/112 166/18800 0.003171932 0.02437197 0.018964813 APOH/CD36/CAV1/ALOX5/PLPP3 5 BP GO:0022900 electron transport chain 5/112 167/18800 0.003254578 0.024916388 0.019388447 GPD1/HSD17B6/ALDH2/SRD5A1/GPX2 5 BP GO:0022600 digestive system process 4/112 104/18800 0.003474574 0.026122251 0.020326777 CD36/LDLR/CEL/AKR1C1 4 BP GO:0009409 response to cold 3/112 51/18800 0.003481755 0.026122251 0.020326777 LPL/ADRB1/ADRB2 3 BP GO:0031668 cellular response to extracellular stimulus 6/112 245/18800 0.003493659 0.026122251 0.020326777 SLC2A1/LPL/MFSD2A/SRD5A1/CYP24A1/AKR1C3 6 BP GO:0010889 regulation of sequestering of triglyceride 2/112 15/18800 0.003510989 0.026122251 0.020326777 LPL/PPARG 2 BP GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway 2/112 15/18800 0.003510989 0.026122251 0.020326777 ALOX15B/PTGIS 2 BP GO:0046512 sphingosine biosynthetic process 2/112 15/18800 0.003510989 0.026122251 0.020326777 ASAH1/SPHK1 2 BP GO:0046520 sphingoid biosynthetic process 2/112 15/18800 0.003510989 0.026122251 0.020326777 ASAH1/SPHK1 2 BP GO:0046834 lipid phosphorylation 2/112 15/18800 0.003510989 0.026122251 0.020326777 DGKA/SPHK1 2 BP GO:0034381 plasma lipoprotein particle clearance 3/112 53/18800 0.003883048 0.028789058 0.022401927 CD36/LDLR/APOC1 3 BP GO:0006857 oligopeptide transport 2/112 16/18800 0.003996997 0.029305843 0.022804059 ABCC1/CA2 2 BP GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 2/112 16/18800 0.003996997 0.029305843 0.022804059 CAV1/SOCS3 2 BP GO:0090520 sphingolipid mediated signaling pathway 2/112 16/18800 0.003996997 0.029305843 0.022804059 SPNS2/SPHK1 2 BP GO:0050708 regulation of protein secretion 6/112 252/18800 0.004008229 0.029305843 0.022804059 PLA2G1B/ANKRD1/ALOX5/SLC16A1/PPARG/ACSL4 6 BP GO:0032102 negative regulation of response to external stimulus 8/112 429/18800 0.0041539 0.030162166 0.023470398 APOH/ALOX5/PPARG/TNFAIP8L2/PTGIS/LDLR/SOCS3/TNFRSF1B 8 BP GO:0042060 wound healing 8/112 429/18800 0.0041539 0.030162166 0.023470398 APOH/CD36/CAV1/ALOX5/PLPP3/DGKA/PPARG/CYP4F11 8 BP GO:1904645 response to amyloid-beta 3/112 55/18800 0.004311409 0.031198653 0.02427693 CD36/ADRB2/ABCC1 3 BP GO:0001933 negative regulation of protein phosphorylation 7/112 341/18800 0.00433235 0.031243196 0.024311591 FABP4/GPD1L/CAV1/PLPP3/PPARG/SOCS3/TRIB3 7 BP GO:0006979 response to oxidative stress 8/112 433/18800 0.004390396 0.031554103 0.02455352 ALDH3B1/CD36/GPX3/ALOX5/GPX2/SPHK1/ABCC1/AKR1C3 8 BP GO:0033194 response to hydroperoxide 2/112 17/18800 0.00451237 0.031782129 0.024730956 CD36/GPX3 2 BP GO:0045019 negative regulation of nitric oxide biosynthetic process 2/112 17/18800 0.00451237 0.031782129 0.024730956 CAV1/PTGIS 2 BP GO:0050802 "circadian sleep/wake cycle, sleep" 2/112 17/18800 0.00451237 0.031782129 0.024730956 ADRB1/SRD5A1 2 BP GO:0060192 negative regulation of lipase activity 2/112 17/18800 0.00451237 0.031782129 0.024730956 SORT1/APOC1 2 BP GO:0090594 inflammatory response to wounding 2/112 17/18800 0.00451237 0.031782129 0.024730956 ALOX5/PPARG 2 BP GO:1904406 negative regulation of nitric oxide metabolic process 2/112 17/18800 0.00451237 0.031782129 0.024730956 CAV1/PTGIS 2 BP GO:0045765 regulation of angiogenesis 7/112 345/18800 0.004614336 0.032392332 0.02520578 NPR1/APOH/ALOX5/PPARG/PTGIS/ENPP2/SPHK1 7 BP GO:0018958 phenol-containing compound metabolic process 4/112 113/18800 0.004671045 0.03268185 0.025431065 NPR1/ALDH2/SRD5A1/MAOA 4 BP GO:0006584 catecholamine metabolic process 3/112 58/18800 0.005005837 0.034510613 0.0268541 NPR1/ALDH2/MAOA 3 BP GO:0009712 catechol-containing compound metabolic process 3/112 58/18800 0.005005837 0.034510613 0.0268541 NPR1/ALDH2/MAOA 3 BP GO:0045604 regulation of epidermal cell differentiation 3/112 58/18800 0.005005837 0.034510613 0.0268541 ALOX15B/GRHL1/PLAAT4 3 BP GO:0090303 positive regulation of wound healing 3/112 58/18800 0.005005837 0.034510613 0.0268541 APOH/CD36/PLPP3 3 BP GO:0030730 sequestering of triglyceride 2/112 18/18800 0.005056748 0.034510613 0.0268541 LPL/PPARG 2 BP GO:0071071 regulation of phospholipid biosynthetic process 2/112 18/18800 0.005056748 0.034510613 0.0268541 LPCAT1/FABP3 2 BP GO:0150079 negative regulation of neuroinflammatory response 2/112 18/18800 0.005056748 0.034510613 0.0268541 LDLR/TNFRSF1B 2 BP GO:1901342 regulation of vasculature development 7/112 351/18800 0.005063081 0.034510613 0.0268541 NPR1/APOH/ALOX5/PPARG/PTGIS/ENPP2/SPHK1 7 BP GO:0051091 positive regulation of DNA-binding transcription factor activity 6/112 265/18800 0.005110167 0.03471956 0.02701669 PLA2G1B/CD36/CAV1/PLPP3/PPARG/SPHK1 6 BP GO:0008544 epidermis development 7/112 355/18800 0.005380021 0.036435848 0.028352203 ASAH1/ALOX15B/GRHL1/CERS3/SLC44A4/PLAAT4/AKR1C3 7 BP GO:0010985 negative regulation of lipoprotein particle clearance 2/112 19/18800 0.005629771 0.03764464 0.029292813 LDLR/APOC1 2 BP GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 2/112 19/18800 0.005629771 0.03764464 0.029292813 ACSL5/ACSL4 2 BP GO:0042574 retinal metabolic process 2/112 19/18800 0.005629771 0.03764464 0.029292813 AKR1C1/AKR1C3 2 BP GO:0045618 positive regulation of keratinocyte differentiation 2/112 19/18800 0.005629771 0.03764464 0.029292813 ALOX15B/PLAAT4 2 BP GO:0045428 regulation of nitric oxide biosynthetic process 3/112 61/18800 0.00576398 0.038299655 0.029802507 CD36/CAV1/PTGIS 3 BP GO:0050994 regulation of lipid catabolic process 3/112 61/18800 0.00576398 0.038299655 0.029802507 MFSD2A/LDLR/APOC1 3 BP GO:0022410 circadian sleep/wake cycle process 2/112 20/18800 0.006231087 0.040636685 0.031621044 ADRB1/SRD5A1 2 BP GO:0042359 vitamin D metabolic process 2/112 20/18800 0.006231087 0.040636685 0.031621044 CYP27A1/CYP24A1 2 BP GO:0042953 lipoprotein transport 2/112 20/18800 0.006231087 0.040636685 0.031621044 CD36/PPARG 2 BP GO:0043651 linoleic acid metabolic process 2/112 20/18800 0.006231087 0.040636685 0.031621044 ALOX5/ALOX15B 2 BP GO:0071379 cellular response to prostaglandin stimulus 2/112 20/18800 0.006231087 0.040636685 0.031621044 AKR1C2/AKR1C3 2 BP GO:1903978 regulation of microglial cell activation 2/112 20/18800 0.006231087 0.040636685 0.031621044 LDLR/SPHK1 2 BP GO:0040014 regulation of multicellular organism growth 3/112 64/18800 0.006587335 0.042696435 0.033223819 ADRB1/ADRB2/MFSD2A 3 BP GO:0080164 regulation of nitric oxide metabolic process 3/112 64/18800 0.006587335 0.042696435 0.033223819 CD36/CAV1/PTGIS 3 BP GO:0003085 negative regulation of systemic arterial blood pressure 2/112 21/18800 0.006860343 0.043897517 0.034158428 ADRB1/ADRB2 2 BP GO:0044872 lipoprotein localization 2/112 21/18800 0.006860343 0.043897517 0.034158428 CD36/PPARG 2 BP GO:0046514 ceramide catabolic process 2/112 21/18800 0.006860343 0.043897517 0.034158428 ASAH1/CEL 2 BP GO:0006940 regulation of smooth muscle contraction 3/112 65/18800 0.006876516 0.043897517 0.034158428 ADRB2/CAV1/SPHK1 3 BP GO:0045682 regulation of epidermis development 3/112 65/18800 0.006876516 0.043897517 0.034158428 ALOX15B/GRHL1/PLAAT4 3 BP GO:0034599 cellular response to oxidative stress 6/112 284/18800 0.007100897 0.045193358 0.035166775 ALDH3B1/CD36/ALOX5/SPHK1/ABCC1/AKR1C3 6 BP GO:0030193 regulation of blood coagulation 3/112 66/18800 0.007173142 0.045379785 0.035311841 APOH/CD36/CAV1 3 BP GO:1900076 regulation of cellular response to insulin stimulus 3/112 66/18800 0.007173142 0.045379785 0.035311841 LPL/SORBS1/SOCS3 3 BP GO:0050714 positive regulation of protein secretion 4/112 128/18800 0.007231806 0.045614346 0.035494363 PLA2G1B/ANKRD1/PPARG/ACSL4 4 BP GO:0010866 regulation of triglyceride biosynthetic process 2/112 22/18800 0.007517192 0.047273292 0.036785255 MFSD2A/LDLR 2 BP GO:0031349 positive regulation of defense response 6/112 289/18800 0.007706933 0.048322701 0.037601843 LPL/FABP4/ALOX5AP/LDLR/ABCC1/PLA2G2A 6 BP GO:1900046 regulation of hemostasis 3/112 68/18800 0.007788906 0.048692186 0.037889354 APOH/CD36/CAV1 3 BP GO:0042326 negative regulation of phosphorylation 7/112 382/18800 0.007924787 0.049395501 0.038436631 FABP4/GPD1L/CAV1/PLPP3/PPARG/SOCS3/TRIB3 7 BP GO:0032370 positive regulation of lipid transport 3/112 69/18800 0.008108131 0.050084745 0.03897296 ACSL5/FABP3/PTGES 3 BP GO:0050795 regulation of behavior 3/112 69/18800 0.008108131 0.050084745 0.03897296 AGRP/LEPR/ADRB1 3 BP GO:0030194 positive regulation of blood coagulation 2/112 23/18800 0.008201288 0.050084745 0.03897296 APOH/CD36 2 BP GO:0042745 circadian sleep/wake cycle 2/112 23/18800 0.008201288 0.050084745 0.03897296 ADRB1/SRD5A1 2 BP GO:0090208 positive regulation of triglyceride metabolic process 2/112 23/18800 0.008201288 0.050084745 0.03897296 MFSD2A/LDLR 2 BP GO:0097164 ammonium ion metabolic process 2/112 23/18800 0.008201288 0.050084745 0.03897296 ALDH2/SRD5A1 2 BP GO:1900048 positive regulation of hemostasis 2/112 23/18800 0.008201288 0.050084745 0.03897296 APOH/CD36 2 BP GO:0032890 regulation of organic acid transport 3/112 70/18800 0.008434971 0.051363383 0.03996792 ACSL5/FABP3/PTGES 3 BP GO:0043588 skin development 6/112 296/18800 0.008617036 0.052321255 0.040713279 ASAH1/ALOX15B/GRHL1/CERS3/PLAAT4/AKR1C3 6 BP GO:0050818 regulation of coagulation 3/112 71/18800 0.008769467 0.052942522 0.041196712 APOH/CD36/CAV1 3 BP GO:2000379 positive regulation of reactive oxygen species metabolic process 3/112 71/18800 0.008769467 0.052942522 0.041196712 CD36/AKR1C1/AKR1C3 3 BP GO:0050820 positive regulation of coagulation 2/112 24/18800 0.00891229 0.053651478 0.041748379 APOH/CD36 2 BP GO:1903036 positive regulation of response to wounding 3/112 72/18800 0.009111654 0.054695811 0.042561017 APOH/CD36/PLPP3 3 BP GO:0051047 positive regulation of secretion 6/112 300/18800 0.009170493 0.054893065 0.042714508 NPR1/PLA2G1B/ANKRD1/PPARG/ACSL4/PTGES 6 BP GO:0031644 regulation of nervous system process 4/112 138/18800 0.009372088 0.055941306 0.043530187 ADRB2/MGLL/TNFRSF1B/TNFRSF21 4 BP GO:0150076 neuroinflammatory response 3/112 73/18800 0.00946157 0.056316333 0.04382201 LDLR/SPHK1/TNFRSF1B 3 BP GO:0051223 regulation of protein transport 8/112 495/18800 0.009550985 0.056639309 0.044073331 PLA2G1B/SLC51B/ANKRD1/CD36/ALOX5/SLC16A1/PPARG/ACSL4 8 BP GO:0006658 phosphatidylserine metabolic process 2/112 25/18800 0.009649859 0.056639309 0.044073331 PLA1A/MFSD2A 2 BP GO:0035336 long-chain fatty-acyl-CoA metabolic process 2/112 25/18800 0.009649859 0.056639309 0.044073331 ACSL5/ACSL4 2 BP GO:0042430 indole-containing compound metabolic process 2/112 25/18800 0.009649859 0.056639309 0.044073331 ALDH2/SRD5A1 2 BP GO:0046949 fatty-acyl-CoA biosynthetic process 2/112 25/18800 0.009649859 0.056639309 0.044073331 ACSL5/ACSL4 2 BP GO:0035296 regulation of tube diameter 4/112 141/18800 0.010086385 0.058874399 0.045812544 NPR1/ADRB1/ADRB2/CAV1 4 BP GO:0097746 blood vessel diameter maintenance 4/112 141/18800 0.010086385 0.058874399 0.045812544 NPR1/ADRB1/ADRB2/CAV1 4 BP GO:0006809 nitric oxide biosynthetic process 3/112 75/18800 0.010184724 0.059121762 0.046005028 CD36/CAV1/PTGIS 3 BP GO:0045685 regulation of glial cell differentiation 3/112 75/18800 0.010184724 0.059121762 0.046005028 LDLR/TNFRSF1B/TNFRSF21 3 BP GO:0035150 regulation of tube size 4/112 142/18800 0.01033211 0.059371237 0.046199154 NPR1/ADRB1/ADRB2/CAV1 4 BP GO:0002026 regulation of the force of heart contraction 2/112 26/18800 0.010413658 0.059371237 0.046199154 ADRB1/CAV1 2 BP GO:0034377 plasma lipoprotein particle assembly 2/112 26/18800 0.010413658 0.059371237 0.046199154 MFSD2A/APOC1 2 BP GO:0050995 negative regulation of lipid catabolic process 2/112 26/18800 0.010413658 0.059371237 0.046199154 MFSD2A/APOC1 2 BP GO:0060259 regulation of feeding behavior 2/112 26/18800 0.010413658 0.059371237 0.046199154 AGRP/LEPR 2 BP GO:1904385 cellular response to angiotensin 2/112 26/18800 0.010413658 0.059371237 0.046199154 CAV1/CA2 2 BP GO:0007596 blood coagulation 5/112 221/18800 0.010424387 0.059371237 0.046199154 APOH/CD36/CAV1/DGKA/CYP4F11 5 BP GO:0046165 alcohol biosynthetic process 4/112 143/18800 0.010581686 0.060105113 0.046770212 ASAH1/PTS/CYP27A1/SPHK1 4 BP GO:0010875 positive regulation of cholesterol efflux 2/112 27/18800 0.011203355 0.062792277 0.048861203 CAV1/PPARG 2 BP GO:0018904 ether metabolic process 2/112 27/18800 0.011203355 0.062792277 0.048861203 ALOX5/PLAAT3 2 BP GO:0045606 positive regulation of epidermal cell differentiation 2/112 27/18800 0.011203355 0.062792277 0.048861203 ALOX15B/PLAAT4 2 BP GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT 2/112 27/18800 0.011203355 0.062792277 0.048861203 CAV1/SOCS3 2 BP GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 2/112 27/18800 0.011203355 0.062792277 0.048861203 ADRB1/ADRB2 2 BP GO:0010827 regulation of glucose transmembrane transport 3/112 78/18800 0.01132823 0.063324207 0.049275119 PLA2G1B/SORBS1/TRIB3 3 BP GO:0050817 coagulation 5/112 226/18800 0.011402283 0.063569984 0.049466368 APOH/CD36/CAV1/DGKA/CYP4F11 5 BP GO:0009410 response to xenobiotic stimulus 7/112 411/18800 0.011550367 0.06422612 0.049976935 ANKRD1/LPL/SRD5A1/ABCC1/CBR3/AKR1C1/ALDH3A1 7 CC GO:0005811 lipid droplet 8/112 100/19594 1.06E-07 1.97E-05 1.64E-05 FABP4/CAV1/HSD17B11/ALDH3B2/LPCAT1/ACSL4/HILPDA/G0S2 8 CC GO:0005901 caveola 6/112 82/19594 7.50E-06 0.000693484 0.000576095 SLC2A1/SORBS1/CD36/CAV1/PLPP2/PTGIS 6 CC GO:0005641 nuclear envelope lumen 3/112 10/19594 2.12E-05 0.001196584 0.000994033 ALOX5/PLAAT1/PTGES 3 CC GO:0044853 plasma membrane raft 6/112 113/19594 4.69E-05 0.001196584 0.000994033 SLC2A1/SORBS1/CD36/CAV1/PLPP2/PTGIS 6 CC GO:0016323 basolateral plasma membrane 8/112 226/19594 4.70E-05 0.001196584 0.000994033 SLC51B/SLC2A1/LEPR/SLC16A1/HPGD/PLPP3/LDLR/ABCC1 8 CC GO:0042627 chylomicron 3/112 13/19594 4.99E-05 0.001196584 0.000994033 LPL/APOH/APOC1 3 CC GO:0034358 plasma lipoprotein particle 4/112 36/19594 5.17E-05 0.001196584 0.000994033 LPL/APOH/LDLR/APOC1 4 CC GO:1990777 lipoprotein particle 4/112 36/19594 5.17E-05 0.001196584 0.000994033 LPL/APOH/LDLR/APOC1 4 CC GO:0032994 protein-lipid complex 4/112 39/19594 7.13E-05 0.00141864 0.0011785 LPL/APOH/LDLR/APOC1 4 CC GO:0030667 secretory granule membrane 9/112 312/19594 7.67E-05 0.00141864 0.0011785 CA4/ALDH3B1/CD36/OLR1/PLA1A/CAV1/LPCAT1/PLD1/TNFRSF1B 9 CC GO:0009925 basal plasma membrane 8/112 251/19594 9.80E-05 0.001559501 0.001295517 SLC51B/SLC2A1/LEPR/SLC16A1/HPGD/PLPP3/LDLR/ABCC1 8 CC GO:0045121 membrane raft 9/112 326/19594 0.000107076 0.001559501 0.001295517 SLC2A1/SORBS1/CD36/OLR1/CAV1/PLPP2/PLPP3/PTGIS/TNFRSF1B 9 CC GO:0098857 membrane microdomain 9/112 327/19594 0.000109587 0.001559501 0.001295517 SLC2A1/SORBS1/CD36/OLR1/CAV1/PLPP2/PLPP3/PTGIS/TNFRSF1B 9 CC GO:0045178 basal part of cell 8/112 269/19594 0.000157828 0.00198202 0.001646514 SLC51B/SLC2A1/LEPR/SLC16A1/HPGD/PLPP3/LDLR/ABCC1 8 CC GO:0045177 apical part of cell 10/112 424/19594 0.000160704 0.00198202 0.001646514 CA4/SLC2A1/CD36/ADRB2/SLC16A1/PLD1/LDLR/SLC44A4/ABCC1/CA2 10 CC GO:0035579 specific granule membrane 5/112 91/19594 0.000175448 0.001984366 0.001648464 ALDH3B1/CD36/OLR1/PLD1/TNFRSF1B 5 CC GO:0034361 very-low-density lipoprotein particle 3/112 20/19594 0.000193073 0.001984366 0.001648464 LPL/APOH/APOC1 3 CC GO:0034385 triglyceride-rich plasma lipoprotein particle 3/112 20/19594 0.000193073 0.001984366 0.001648464 LPL/APOH/APOC1 3 CC GO:0005769 early endosome 9/112 389/19594 0.000397019 0.003865713 0.003211346 HSD17B6/AOC3/ADRB1/ADRB2/CAV1/PLPP2/SORT1/LDLR/SPHK1 9 CC GO:0016324 apical plasma membrane 8/112 358/19594 0.001049697 0.009709697 0.008066093 CA4/SLC2A1/CD36/ADRB2/SLC16A1/PLD1/SLC44A4/ABCC1 8 CC GO:0031970 organelle envelope lumen 4/112 93/19594 0.001998078 0.017602117 0.014622527 ALOX5/CPOX/PLAAT1/PTGES 4 CC GO:0042581 specific granule 5/112 160/19594 0.002267454 0.019067223 0.015839628 ALDH3B1/CD36/OLR1/PLD1/TNFRSF1B 5 MF GO:0016614 "oxidoreductase activity, acting on CH-OH group of donors" 17/112 140/18410 1.02E-17 3.68E-15 2.52E-15 GPD1/ADH1B/HSD17B6/HSD17B11/HPGD/CYP27A1/LDHA/BDH1/AKR1B10/AKR1C2/ADH7/CBR3/AKR1B15/AKR1C1/ALDH3A1/CYP4F3/AKR1C3 17 MF GO:0016616 "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" 16/112 128/18410 6.18E-17 1.11E-14 7.61E-15 GPD1/ADH1B/HSD17B6/HSD17B11/HPGD/CYP27A1/LDHA/BDH1/AKR1B10/AKR1C2/ADH7/CBR3/AKR1B15/AKR1C1/ALDH3A1/AKR1C3 16 MF GO:0052689 carboxylic ester hydrolase activity 15/112 149/18410 1.64E-14 1.96E-12 1.35E-12 PLA2G1B/LPL/PLA1A/PAFAH1B3/ALDH2/PLA2G4F/MGLL/ENPP2/PLAAT3/PLAAT1/PLAAT4/LIPH/CA2/CEL/PLA2G2A 15 MF GO:0016298 lipase activity 13/112 130/18410 1.11E-12 9.94E-11 6.82E-11 PLA2G1B/LPL/PLA1A/PLA2G4F/MGLL/PLD1/ENPP2/PLAAT3/PLAAT1/PLAAT4/LIPH/CEL/PLA2G2A 13 MF GO:0004620 phospholipase activity 12/112 106/18410 1.92E-12 1.38E-10 9.46E-11 PLA2G1B/LPL/PLA1A/PLA2G4F/MGLL/PLD1/ENPP2/PLAAT3/PLAAT1/PLAAT4/LIPH/PLA2G2A 12 MF GO:0033293 monocarboxylic acid binding 10/112 81/18410 6.04E-11 3.61E-09 2.48E-09 PLA2G1B/FABP4/ALOX5AP/PPARG/FABP3/AKR1C2/APOC1/CYP4F11/AKR1C1/AKR1C3 10 MF GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 6/112 13/18410 7.34E-11 3.76E-09 2.58E-09 HSD17B6/HSD17B11/AKR1C2/AKR1B15/AKR1C1/AKR1C3 6 MF GO:0016903 "oxidoreductase activity, acting on the aldehyde or oxo group of donors" 8/112 46/18410 3.14E-10 1.41E-08 9.65E-09 ALDH3B1/ALDH2/ALDH3B2/CYP27A1/AKR1B10/ADH7/ALDH3A1/AKR1C3 8 MF GO:0008970 phospholipase A1 activity 6/112 17/18410 5.19E-10 2.07E-08 1.42E-08 LPL/PLA1A/PLA2G4F/PLAAT3/PLAAT1/PLAAT4 6 MF GO:0004303 estradiol 17-beta-dehydrogenase activity 6/112 18/18410 7.75E-10 2.78E-08 1.91E-08 HSD17B6/HSD17B11/AKR1C2/AKR1B15/AKR1C1/AKR1C3 6 MF GO:0016229 steroid dehydrogenase activity 7/112 34/18410 1.20E-09 3.91E-08 2.68E-08 HSD17B6/HSD17B11/SRD5A1/AKR1C2/AKR1B15/AKR1C1/AKR1C3 7 MF GO:0016620 "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor" 7/112 38/18410 2.76E-09 8.25E-08 5.66E-08 ALDH3B1/ALDH2/ALDH3B2/CYP27A1/AKR1B10/ALDH3A1/AKR1C3 7 MF GO:0052739 phosphatidylserine 1-acylhydrolase activity 5/112 11/18410 3.42E-09 9.44E-08 6.48E-08 LPL/PLA1A/PLAAT3/PLAAT1/PLAAT4 5 MF GO:0008106 alcohol dehydrogenase (NADP+) activity 6/112 23/18410 4.11E-09 1.05E-07 7.23E-08 AKR1B10/AKR1C2/AKR1B15/AKR1C1/ALDH3A1/AKR1C3 6 MF GO:0004032 alditol:NADP+ 1-oxidoreductase activity 5/112 12/18410 5.83E-09 1.40E-07 9.57E-08 AKR1B10/AKR1C2/AKR1B15/AKR1C1/AKR1C3 5 MF GO:0004497 monooxygenase activity 9/112 103/18410 1.28E-08 2.88E-07 1.98E-07 CYP4B1/CYP27A1/PTGIS/AKR1C2/CYP4F11/CYP24A1/AKR1C1/CYP4F3/AKR1C3 9 MF GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) activity 5/112 14/18410 1.46E-08 3.08E-07 2.11E-07 HSD17B6/HSD17B11/AKR1C2/AKR1C1/AKR1C3 5 MF GO:0004033 aldo-keto reductase (NADP) activity 6/112 30/18410 2.33E-08 4.41E-07 3.03E-07 AKR1B10/AKR1C2/AKR1B15/AKR1C1/ALDH3A1/AKR1C3 6 MF GO:0033764 "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor" 6/112 30/18410 2.33E-08 4.41E-07 3.03E-07 HSD17B6/HSD17B11/AKR1C2/AKR1B15/AKR1C1/AKR1C3 6 MF GO:0004623 phospholipase A2 activity 6/112 34/18410 5.19E-08 9.31E-07 6.39E-07 PLA2G1B/PLA2G4F/PLAAT3/PLAAT1/PLAAT4/PLA2G2A 6 MF GO:0047834 D-threo-aldose 1-dehydrogenase activity 5/112 18/18410 6.13E-08 1.05E-06 7.19E-07 AKR1B10/AKR1C2/AKR1B15/AKR1C1/AKR1C3 5 MF GO:0031406 carboxylic acid binding 10/112 173/18410 1.03E-07 1.67E-06 1.15E-06 PLA2G1B/FABP4/ALOX5AP/PPARG/FABP3/AKR1C2/APOC1/CYP4F11/AKR1C1/AKR1C3 10 MF GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity 4/112 10/18410 2.65E-07 4.14E-06 2.84E-06 LPL/PLAAT3/PLAAT1/PLAAT4 4 MF GO:0032052 bile acid binding 4/112 11/18410 4.14E-07 6.20E-06 4.25E-06 PLA2G1B/AKR1C2/AKR1C1/AKR1C3 4 MF GO:0005504 fatty acid binding 6/112 49/18410 5.01E-07 7.19E-06 4.93E-06 FABP4/ALOX5AP/PPARG/FABP3/APOC1/CYP4F11 6 MF GO:0016705 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" 9/112 177/18410 1.35E-06 1.86E-05 1.27E-05 CYP4B1/CYP27A1/PTGIS/AKR1C2/CYP4F11/CYP24A1/AKR1C1/CYP4F3/AKR1C3 9 MF GO:0016627 "oxidoreductase activity, acting on the CH-CH group of donors" 6/112 59/18410 1.54E-06 2.04E-05 1.40E-05 ACADL/CPOX/SRD5A1/AKR1C2/AKR1C1/AKR1C3 6 MF GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/112 15/18410 1.68E-06 2.08E-05 1.43E-05 ALDH3B1/ALDH2/ALDH3B2/ALDH3A1 4 MF GO:0036041 long-chain fatty acid binding 4/112 15/18410 1.68E-06 2.08E-05 1.43E-05 FABP4/ALOX5AP/PPARG/FABP3 4 MF GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/112 16/18410 2.23E-06 2.67E-05 1.83E-05 ALDH3B1/ALDH2/ALDH3B2/ALDH3A1 4 MF GO:0005324 long-chain fatty acid transporter activity 4/112 17/18410 2.91E-06 3.37E-05 2.31E-05 SLC2A1/CD36/FABP4/MFSD2A 4 MF GO:0005506 iron ion binding 8/112 151/18410 3.93E-06 4.41E-05 3.03E-05 CYP4B1/ALOX5/ALOX15B/CYP27A1/PTGIS/CYP4F11/CYP24A1/CYP4F3 8 MF GO:0004745 NAD-retinol dehydrogenase activity 4/112 19/18410 4.69E-06 5.10E-05 3.50E-05 ADH1B/HSD17B6/ADH7/AKR1C3 4 MF GO:0005319 lipid transporter activity 8/112 159/18410 5.77E-06 6.09E-05 4.18E-05 SLC51B/SLC2A1/CD36/FABP4/SPNS2/MFSD2A/NPC2/ABCC1 8 MF GO:0016709 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen" 5/112 43/18410 6.10E-06 6.25E-05 4.29E-05 CYP27A1/AKR1C2/CYP4F11/AKR1C1/AKR1C3 5 MF GO:0004602 glutathione peroxidase activity 4/112 22/18410 8.73E-06 8.70E-05 5.97E-05 GPX3/ALOX5AP/GPX2/PTGES 4 MF GO:0004806 triglyceride lipase activity 4/112 26/18410 1.75E-05 0.0001698 0.000116502 LPL/PLA1A/LIPH/CEL 4 MF GO:0016628 "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor" 4/112 29/18410 2.74E-05 0.000258993 0.000177699 SRD5A1/AKR1C2/AKR1C1/AKR1C3 4 MF GO:0030283 testosterone dehydrogenase [NAD(P)] activity 3/112 11/18410 3.49E-05 0.000321296 0.000220447 HSD17B6/AKR1C1/AKR1C3 3 MF GO:0016747 "acyltransferase activity, transferring groups other than amino-acyl groups" 8/112 218/18410 5.63E-05 0.000504914 0.00034643 PAFAH1B3/LPCAT1/CERS6/CERS3/SPHK1/PLAAT3/PLAAT1/PLAAT4 8 MF GO:0052650 NADP-retinol dehydrogenase activity 3/112 14/18410 7.60E-05 0.000665301 0.000456474 AKR1B10/AKR1B15/AKR1C3 3 MF GO:0005041 low-density lipoprotein particle receptor activity 3/112 15/18410 9.46E-05 0.00080823 0.00055454 CD36/OLR1/LDLR 3 MF GO:0047498 calcium-dependent phospholipase A2 activity 3/112 16/18410 0.000115862 0.000967309 0.000663687 PLA2G1B/PLA2G4F/PLA2G2A 3 MF GO:0016746 acyltransferase activity 8/112 244/18410 0.000123349 0.001006414 0.000690517 PAFAH1B3/LPCAT1/CERS6/CERS3/SPHK1/PLAAT3/PLAAT1/PLAAT4 8 MF GO:0030228 lipoprotein particle receptor activity 3/112 18/18410 0.000167336 0.001334967 0.000915943 CD36/OLR1/LDLR 3 MF GO:0020037 heme binding 6/112 139/18410 0.00020642 0.001610975 0.001105316 CYP4B1/CYP27A1/PTGIS/CYP4F11/CYP24A1/CYP4F3 6 MF GO:0016410 N-acyltransferase activity 5/112 91/18410 0.000233675 0.001784876 0.001224632 CERS6/CERS3/PLAAT3/PLAAT1/PLAAT4 5 MF GO:0051287 NAD binding 4/112 51/18410 0.000260228 0.001946291 0.001335382 GPD1/GPD1L/ALDH2/HPGD 4 MF GO:0004601 peroxidase activity 4/112 52/18410 0.0002806 0.002055828 0.001410537 GPX3/ALOX5AP/GPX2/PTGES 4 MF GO:0046906 tetrapyrrole binding 6/112 149/18410 0.000300404 0.002156901 0.001479885 CYP4B1/CYP27A1/PTGIS/CYP4F11/CYP24A1/CYP4F3 6 MF GO:0016684 "oxidoreductase activity, acting on peroxide as acceptor" 4/112 56/18410 0.000373645 0.002630168 0.001804601 GPX3/ALOX5AP/GPX2/PTGES 4 MF GO:0004622 lysophospholipase activity 3/112 24/18410 0.000404169 0.002737671 0.001878361 PLA2G4F/MGLL/ENPP2 3 MF GO:0016702 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" 3/112 24/18410 0.000404169 0.002737671 0.001878361 ALOX5AP/ALOX5/ALOX15B 3 MF GO:0008028 monocarboxylic acid transmembrane transporter activity 4/112 59/18410 0.000456565 0.002931324 0.002011229 SLC51B/CD36/SLC16A1/MFSD2A 4 MF GO:0016701 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen" 3/112 25/18410 0.000457254 0.002931324 0.002011229 ALOX5AP/ALOX5/ALOX15B 3 MF GO:0070330 aromatase activity 3/112 25/18410 0.000457254 0.002931324 0.002011229 CYP4B1/CYP4F11/CYP4F3 3 MF GO:0004364 glutathione transferase activity 3/112 26/18410 0.000514613 0.003241159 0.002223812 HPGDS/ALOX5AP/PTGES 3 MF GO:0033218 amide binding 9/112 402/18410 0.000782764 0.004845038 0.00332426 NPR1/ACADL/LEPR/CD36/ADRB2/SRD5A1/PPARG/LDLR/PTGES 9 MF GO:0071813 lipoprotein particle binding 3/112 31/18410 0.00087023 0.005121519 0.003513958 LPL/CD36/LDLR 3 MF GO:0071814 protein-lipid complex binding 3/112 31/18410 0.00087023 0.005121519 0.003513958 LPL/CD36/LDLR 3 MF GO:0090482 vitamin transmembrane transporter activity 3/112 31/18410 0.00087023 0.005121519 0.003513958 SLC2A1/SLC44A4/ABCC1 3 MF GO:0008514 organic anion transmembrane transporter activity 6/112 186/18410 0.00096801 0.005605089 0.003845744 SLC2A1/CD36/SLC16A1/MFSD2A/SLC44A4/ABCC1 6 MF GO:0016829 lyase activity 6/112 195/18410 0.001234679 0.00703571 0.004827316 CA4/NPR1/ALOX5AP/PTS/PTGIS/CA2 6 MF GO:0016835 carbon-oxygen lyase activity 4/112 79/18410 0.001373212 0.007584356 0.005203751 CA4/PTS/PTGIS/CA2 4 MF GO:0038024 cargo receptor activity 4/112 79/18410 0.001373212 0.007584356 0.005203751 CD36/OLR1/LDLR/ENPP2 4 MF GO:0004465 lipoprotein lipase activity 2/112 10/18410 0.001598907 0.008200109 0.005626229 LPL/LIPH 2 MF GO:0004955 prostaglandin receptor activity 2/112 10/18410 0.001598907 0.008200109 0.005626229 HPGD/PPARG 2 MF GO:0015245 fatty acid transmembrane transporter activity 2/112 10/18410 0.001598907 0.008200109 0.005626229 CD36/MFSD2A 2 MF GO:0016634 "oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor" 2/112 10/18410 0.001598907 0.008200109 0.005626229 ACADL/CPOX 2 MF GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/112 10/18410 0.001598907 0.008200109 0.005626229 ADH1B/ADH7 2 MF GO:0016209 antioxidant activity 4/112 85/18410 0.001799675 0.009099767 0.0062435 GPX3/ALOX5AP/GPX2/PTGES 4 MF GO:0016712 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" 3/112 40/18410 0.001838266 0.009165797 0.006288804 CYP4B1/CYP4F11/CYP4F3 3 MF GO:0004954 prostanoid receptor activity 2/112 11/18410 0.001946463 0.009442977 0.006478982 HPGD/PPARG 2 MF GO:0047676 arachidonate-CoA ligase activity 2/112 11/18410 0.001946463 0.009442977 0.006478982 ACSL5/ACSL4 2 MF GO:0004089 carbonate dehydratase activity 2/112 14/18410 0.003182352 0.015032426 0.010313994 CA4/CA2 2 MF GO:0008195 phosphatidate phosphatase activity 2/112 14/18410 0.003182352 0.015032426 0.010313994 PLPP2/PLPP3 2 MF GO:0046943 carboxylic acid transmembrane transporter activity 5/112 164/18410 0.003291592 0.015346513 0.010529494 SLC51B/CD36/SLC16A1/MFSD2A/ABCC1 5 MF GO:0005342 organic acid transmembrane transporter activity 5/112 165/18410 0.003378287 0.015548783 0.010668275 SLC51B/CD36/SLC16A1/MFSD2A/ABCC1 5 MF GO:0016860 intramolecular oxidoreductase activity 3/112 50/18410 0.003489687 0.015858196 0.010880569 HPGDS/PTGIS/PTGES 3 MF GO:0042277 peptide binding 7/112 322/18410 0.003551215 0.015936075 0.010934003 NPR1/LEPR/CD36/ADRB2/PPARG/LDLR/PTGES 7 MF GO:0004467 long-chain fatty acid-CoA ligase activity 2/112 15/18410 0.003657397 0.016012264 0.010986277 ACSL5/ACSL4 2 MF GO:0004953 icosanoid receptor activity 2/112 15/18410 0.003657397 0.016012264 0.010986277 HPGD/PPARG 2 MF GO:0016641 "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor" 2/112 16/18410 0.004163331 0.017583952 0.012064638 AOC3/MAOA 2 MF GO:0042577 lipid phosphatase activity 2/112 16/18410 0.004163331 0.017583952 0.012064638 PLPP2/PLPP3 2 MF GO:0070402 NADPH binding 2/112 16/18410 0.004163331 0.017583952 0.012064638 SRD5A1/CBR3 2 MF GO:0003951 NAD+ kinase activity 2/112 17/18410 0.004699766 0.019618793 0.013460775 DGKA/SPHK1 2 MF GO:0016655 "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor" 3/112 57/18410 0.005051858 0.020846172 0.014302901 AKR1C2/AKR1C1/AKR1C3 3 MF GO:0030169 low-density lipoprotein particle binding 2/112 18/18410 0.00526632 0.021484193 0.014740657 CD36/LDLR 2 MF GO:0016765 "transferase activity, transferring alkyl or aryl (other than methyl) groups" 3/112 59/18410 0.005563779 0.022442659 0.015398276 HPGDS/ALOX5AP/PTGES 3 MF GO:1901681 sulfur compound binding 6/112 267/18410 0.005851445 0.023340762 0.01601448 ACADL/LPL/APOH/LIPH/PTGES/CEL 6 MF GO:0016638 "oxidoreductase activity, acting on the CH-NH2 group of donors" 2/112 20/18410 0.006488268 0.025596576 0.01756223 AOC3/MAOA 2 MF GO:0016836 hydro-lyase activity 3/112 64/18410 0.006976059 0.027221794 0.01867732 CA4/PTGIS/CA2 3 MF GO:0008391 arachidonic acid monooxygenase activity 2/112 21/18410 0.007142914 0.027338717 0.018757542 CYP4F11/CYP4F3 2 MF GO:0009055 electron transfer activity 4/112 125/18410 0.007158327 0.027338717 0.018757542 HSD17B6/ALDH2/SRD5A1/GPX2 4 MF GO:0015645 fatty acid ligase activity 2/112 22/18410 0.00782618 0.029266651 0.020080329 ACSL5/ACSL4 2 MF GO:0016780 "phosphotransferase activity, for other substituted phosphate groups" 2/112 22/18410 0.00782618 0.029266651 0.020080329 SGMS2/SELENOI 2 MF GO:0070412 R-SMAD binding 2/112 24/18410 0.009277112 0.034334878 0.023557723 ANKRD1/PPARG 2 MF GO:0015101 organic cation transmembrane transporter activity 2/112 25/18410 0.010044056 0.036794042 0.025244996 SLC44A5/SLC44A4 2 MF GO:0016405 CoA-ligase activity 2/112 27/18410 0.01165912 0.04227903 0.029008336 ACSL5/ACSL4 2 MF GO:0008509 anion transmembrane transporter activity 6/112 315/18410 0.012613683 0.045283121 0.031069493 SLC2A1/CD36/SLC16A1/MFSD2A/SLC44A4/ABCC1 6 MF GO:0001540 amyloid-beta binding 3/112 81/18410 0.013263014 0.047142794 0.032345444 CD36/ADRB2/LDLR 3 MF GO:0042910 xenobiotic transmembrane transporter activity 2/112 30/18410 0.014279408 0.050257915 0.03448278 SLC2A1/ABCC1 2 MF GO:0016878 acid-thiol ligase activity 2/112 31/18410 0.015204179 0.052483655 0.036009897 ACSL5/ACSL4 2 MF GO:0031210 phosphatidylcholine binding 2/112 31/18410 0.015204179 0.052483655 0.036009897 ESYT3/APOC1 2 MF GO:0046982 protein heterodimerization activity 6/112 332/18410 0.015967198 0.054592609 0.037456885 SLC51B/AOC3/ADRB1/PAFAH1B3/CAV1/H2AZ1 6 MF GO:0015605 organophosphate ester transmembrane transporter activity 2/112 32/18410 0.016154056 0.054710434 0.037537726 MFSD2A/SLC44A4 2 MF GO:0016407 acetyltransferase activity 3/112 88/18410 0.016546401 0.055001463 0.037737406 PAFAH1B3/LPCAT1/SPHK1 3 MF GO:0016651 "oxidoreductase activity, acting on NAD(P)H" 3/112 88/18410 0.016546401 0.055001463 0.037737406 AKR1C2/AKR1C1/AKR1C3 3 MF GO:0043178 alcohol binding 3/112 89/18410 0.01704929 0.056153168 0.038527609 CAV1/NPC2/ADH7 3 MF GO:0051213 dioxygenase activity 3/112 93/18410 0.019145948 0.062485411 0.042872266 ALOX5AP/ALOX5/ALOX15B 3 MF GO:0008201 heparin binding 4/112 168/18410 0.019412378 0.062784179 0.043077255 LPL/APOH/LIPH/CEL 4