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["Supplementary Table 9. GO and KEGG pathway enrichment analyses for the CCMM-MI common targets"]
["Category","ID","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["Biological process","GO:0042493","response to drug",26,20.4724409448818,2.48124979666652e-19,"PTGS2, PPARG, TGFB1, CASP3, BCHE, BCL2, SRD5A1, SRD5A2, DNMT3B, ICAM1, DNMT3A, CDK1, HSP90AA1, ABCB1, CDK4, ABCG2, CCNB1, CCND1, HDAC1, NTRK1, JUN, LCK, MDM2, ABCC4, IGFBP2, SLC9A1",126,304,16792,11.3980785296574,4.74911211081972e-16,4.74911211081972e-16,4.24416893924096E-16]
["Biological process","GO:0010629","negative regulation of gene expression",16,12.5984251968503,9.16155147859871e-14,"XDH, HRAS, TNF, MAP2K1, ESR1, NFKB1, TGFB1, PGR, AKT1, CCNB1, ACE, HDAC1, NOS2, TERT, GBA, OPRD1",126,137,16792,15.564361024215,1.75309766703435e-10,8.76548833517176e-11,1.56674673235102e-10]
["Biological process","GO:0071456","cellular response to hypoxia",13,10.2362204724409,6.23343239153003e-12,"ICAM1, DNMT3A, PTGS2, AKT1, CCNB1, GNB1, BCL2, MDM2, MTOR, CCNA2, TERT, SLC9A1, OPRD1",126,96,16792,18.0469576719576,1.19308388724093e-08,3.97694632781053e-09,1.06623043727438e-08]
["Biological process","GO:0045429","positive regulation of nitric oxide biosynthetic process",10,7.87401574803149,2.38935457293868e-11,"HSP90AB1, AKT1, EGFR, ICAM1, TNF, HSP90AA1, PTGS2, ESR1, MTOR, INSR",126,43,16792,30.9929863418235,4.57322609781485e-08,1.1433065383315e-08,4.08698408449481e-08]
["Biological process","GO:0009636","response to toxic substance",12,9.44881889763779,3.33346303040085e-11,"DNMT3A, MAPK1, CDK1, CYP1B1, BCL2, MAPK3, PON1, MDM2, EPHX1, CDK4, DNMT3B, AHR",126,85,16792,18.8145658263305,6.38025532406771e-08,1.27605109812023E-8,5.70188340986987e-08]
["Biological process","GO:0045944","positive regulation of transcription from RNA polymerase II promoter",30,23.6220472440944,1.0940016040771E-10,"NAMPT, PPARA, HRAS, THRA, TNF, THRB, PPARG, NFKB1, NR3C1, TGFB1, AKT1, PGR, KDM1A, APP, SERPINE1, NR1H4, EGFR, AR, ESR1, NR4A1, AHR, NR1I3, NR1I2, HDAC1, JUN, GSK3B, MAPK3, PARP1, SLC9A1, IL2",126,981,16792,4.07553031406242,2.09391875949371e-07,3.48986490816827E-8,1.871285792987e-07]
["Biological process","GO:0043066","negative regulation of apoptotic process",21,16.5354330708661,1.56158716007606e-10,"EGFR, CDK1, BRAF, MMP9, NFKB1, BCL2L1, AKT1, IGF1R, CASP3, HSP90B1, HDAC1, CCND2, BCL2, GSK3B, MDM2, MPO, MAPK8, HSPA5, NR1H4, SLC9A1, IL2",126,455,16792,6.15091575091575,2.98887807836933e-07,4.26982637025119e-08,2.67108990481546e-07]
["Biological process","GO:0043401","steroid hormone mediated signaling pathway",10,7.87401574803149,3.49309597407821e-10,"PGR, PPARA, NR1I3, NR1I2, THRA, THRB, PPARG, ESR1, NR4A1, NR1H4",126,57,16792,23.3806739069896,6.68578315154988e-07,8.35723138470356e-08,5.9749278857879e-07]
["Biological process","GO:0006468","protein phosphorylation",20,15.7480314960629,1.14844754569339E-9,"FGFR1, SGK1, BRAF, CDK4, ATM, TGFB1, AKT1, CSNK2A2, CCNE1, MAPK1, CCND1, APP, GSK3B, NTRK1, LCK, MAPK3, TNNI3K, MAPK8, MTOR, IGFBP3",126,456,16792,5.84516847674742,2.19812621382597e-06,2.44236484592264e-07,1.96441544142444e-06]
["Biological process","GO:0006367","transcription initiation from RNA polymerase II promoter",13,10.2362204724409,1.43026874213721E-9,"PPARA, AR, THRA, THRB, PPARG, ESR1, NR4A1, NR3C1, ESR2, PGR, NR1I3, NR1I2, NR1H4",126,152,16792,11.3980785296574,2.73753072332905e-06,2.73753409607557e-07,2.44646964908668E-6]
["Biological process","GO:0001934","positive regulation of protein phosphorylation",12,9.44881889763779,2.67273022822708e-09,"AKT1, EGFR, HRAS, CCND1, TNF, CCND2, NTRK1, MMP9, MAPK3, MTOR, INSR, TGFB1",126,127,16792,12.5924259467566,5.11559263849381e-06,4.65054957654587e-07,4.57169548884195e-06]
["Biological process","GO:0030522","intracellular receptor signaling pathway",8,6.29921259842519,1.11427131683421e-08,"PPARA, AR, NR1I2, THRA, THRB, NR4A1, AHR, NR1H4",126,38,16792,28.0568086883876,2.13269257549608E-5,1.77726118544274e-06,1.90595695226392e-05]
["Biological process","GO:0048661","positive regulation of smooth muscle cell proliferation",9,7.08661417322834,1.3919580381862e-08,"AKT1, EGFR, NAMPT, TNF, PTGS2, HMGCR, JUN, ABCC4, MTOR",126,60,16792,19.9904761904761,2.66417221304049e-05,2.04938844061697e-06,2.38093899818103e-05]
["Biological process","GO:0043627","response to estrogen",9,7.08661417322834,2.6620052084424e-08,"MAPK1, CCND1, HSP90AA1, PPARG, ESR1, SRD5A1, ABCC2, IGFBP2, GBA",126,65,16792,18.4527472527472,5.09494823358602E-5,3.63933482794287e-06,4.55334944526875E-5]
["Biological process","GO:0018105","peptidyl-serine phosphorylation",11,8.66141732283464,3.12997621646141e-08,"AKT1, MAPK1, CDK1, SGK1, BCL2, GSK3B, MAPK3, MAPK8, MTOR, ATM, CDK2",126,125,16792,11.727746031746,5.99059511934285e-05,3.99384173299655e-06,5.35381181165917e-05]
["Biological process","GO:0045893","positive regulation of transcription, DNA-templated",19,14.9606299212598,4.93358633900704e-08,"PPARA, AR, TNF, MAP2K1, PPARG, ESR1, NFKB1, ESR2, CDK2, AHR, TGFB1, CCNE1, MAPK1, NR1I2, HDAC1, JUN, MAPK3, INSR, CCNA2",126,515,16792,4.91675142548929,9.44243866036753e-05,5.90178538861785e-06,8.43887850821012e-05]
["Biological process","GO:0008284","positive regulation of cell proliferation",18,14.1732283464566,6.51406240396729e-08,"EGFR, NAMPT, FGFR1, AR, HRAS, BCL2L1, KIT, CDK4, CDK2, TGFB1, IGF1R, MAPK1, HDAC1, CCND2, BCL2, MDM2, INSR, IL2",126,466,16792,5.14776210913549,0.000124671386285024,7.33404124741987e-06,1.11422746895684E-4]
["Biological process","GO:0070374","positive regulation of ERK1 and ERK2 cascade",12,9.44881889763779,7.62691193862817E-8,"EGFR, ICAM1, HRAS, TNF, BRAF, MAP2K1, HMGCR, JUN, NTRK1, MAPK3, TGFB1, PTPN11",126,175,16792,9.13850340136054,0.000145968445578903,8.10991711497344E-6,0.000130457976865727]
["Biological process","GO:0055114","oxidation-reduction process",20,15.7480314960629,7.75266182252915e-08,"XDH, CYP3A4, CYP1B1, PTGS2, HMGCR, PGD, CYP1A2, KDM1A, GSR, CYP17A1, SQLE, FASN, MPO, ABCC4, SRD5A1, NOS3, HSD17B3, NOS2, SRD5A2, CYP19A1",126,592,16792,4.5023595023595,0.000148374944405116,7.80975650660487e-06,0.000132608921565857]
["Biological process","GO:0010628","positive regulation of gene expression",14,11.023622047244,7.81822523033729e-08,"CDK1, HRAS, AR, TNF, BRAF, MAP2K1, KIT, TGFB1, NR1I2, MDM2, MAPK8, MTOR, DNMT3B, GBA",126,262,16792,7.12128922815945,1.4962964119447E-4,7.4820138509235e-06,0.000133730379958674]
["Biological process","GO:0071407","cellular response to organic cyclic compound",8,6.29921259842519,2.64669562302258e-07,"CCNB1, HSP90AB1, ALPL, AKT1, CASP3, TNF, CYP1B1, TGFB1",126,59,16792,18.0704869518428,0.000506449320442636,2.41224523449545E-5,0.000452715378684853]
["Biological process","GO:0006950","response to stress",8,6.29921259842519,3.34325665411036e-07,"HSP90AB1, EGFR, MAPK1, SGK1, HSP90B1, HSP90AA1, MAPK8, MTOR",126,61,16792,17.4780119698152,0.000639694738516327,2.90859147462629e-05,0.000571861320253219]
["Biological process","GO:0018107","peptidyl-threonine phosphorylation",7,5.51181102362204,3.42569886714704e-07,"AKT1, MAPK1, CDK1, BCL2, GSK3B, MAPK8, MTOR",126,38,16792,24.5497076023391,0.000655463964992719,2.85073708490291e-05,0.00058596295456903]
["Biological process","GO:0032355","response to estradiol",9,7.08661417322834,3.81456822511301E-7,"DNMT3A, CASP3, CCND1, PTGS2, ESR1, CYP1A2, IGFBP2, DNMT3B, TGFB1",126,91,16792,13.1805337519623,0.0007298420330899,3.04207246739629E-5,0.000652478531903977]
["Biological process","GO:0051384","response to glucocorticoid",8,6.29921259842519,5.20537397054047e-07,"ALPL, CASP3, TNF, PTGS2, BCHE, BCL2, IGFBP2, GBA",126,65,16792,16.402442002442,0.000995812686446995,3.98515593978965e-05,0.000890373631479146]
["Biological process","GO:0071260","cellular response to mechanical stimulus",8,6.29921259842519,9.583173407671929E-7,"AKT1, EGFR, PTGS2, MAPK3, NFKB1, MAPK8, TGFB1, SLC9A1",126,71,16792,15.0163201430807,0.00183253911523184,7.05444450544989e-05,0.00163918574868082]
["Biological process","GO:0007165","signal transduction",26,20.4724409448818,1.22016178434034E-6,"NAMPT, HRAS, PPARG, NFKB1, NR3C1, KIT, PGR, AKT1, IGF1R, HPGDS, NR1H4, EGFR, AR, HSP90AA1, MAP2K1, ESR1, NR4A1, ESR2, CDK4, ATM, MAPK1, NR1I3, NR1I2, GNB1, MTOR, IGFBP2",126,1161,16792,2.9845097958793,2.33266617599892E-3,8.64922252612476e-05,0.00208706187995177]
["Biological process","GO:0048015","phosphatidylinositol-mediated signaling",9,7.08661417322834,1.2334145074276e-06,"AKT1, EGFR, IGF1R, FGFR1, NTRK1, LCK, KIT, MTOR, PTPN11",126,106,16792,11.3153638814016,0.00235797242822888,8.43091894624503e-05,0.00210973016762094]
["Biological process","GO:0007623","circadian rhythm",8,6.29921259842519,1.39550892749172e-06,"EGFR, NAMPT, JUN, NTRK1, GSK3B, SERPINE1, NOS2, CDK4",126,75,16792,14.2154497354497,0.00266744198842505,9.20994120712226e-05,0.00238698622645472]
["Biological process","GO:0014066","regulation of phosphatidylinositol 3-kinase signaling",8,6.29921259842519,1.82353685046672e-06,"AKT1, EGFR, MAPK1, FGFR1, MAPK3, LCK, KIT, PTPN11",126,78,16792,13.6687016687016,0.00348416886231317,1.16334989700206E-4,3.11910748634902E-3]
["Biological process","GO:0043065","positive regulation of apoptotic process",13,10.2362204724409,2.4745062279988e-06,"NCSTN, AKT1, TNF, CYP1B1, PTGS2, NR4A1, MAPK8, BCL2L1, CDK4, IGFBP3, TGFB1, ATM, SLC9A1",126,300,16792,5.77502645502645,0.0047250126199978,1.52769322492973E-4,0.00423254975104869]
["Biological process","GO:0048146","positive regulation of fibroblast proliferation",7,5.51181102362204,2.90796539777446e-06,"CCNB1, EGFR, JUN, ESR1, CDK4, CCNA2, TGFB1",126,54,16792,17.275720164609,5.55039319669414E-3,0.00017391780779663,0.00497394798241179]
["Biological process","GO:0042220","response to cocaine",6,4.72440944881889,3.61566087924982e-06,"HSP90AB1, DNMT3A, HSP90AA1, MDM2, MTOR, DNMT3B",126,32,16792,24.9880952380952,0.00689649669549008,0.0002096867227801,6.18439499444622E-3]
["Biological process","GO:0031663","lipopolysaccharide-mediated signaling pathway",6,4.72440944881889,3.61566087924982e-06,"AKT1, MAPK1, TNF, MAPK3, NOS3, TGFB1",126,32,16792,24.9880952380952,0.00689649669549008,0.0002096867227801,6.18439499444622E-3]
["Biological process","GO:0006706","steroid catabolic process",4,3.14960629921259,3.98346612714563e-06,"CYP3A4, STS, SRD5A2, CYP1A2",126,5,16792,106.615873015873,0.00759537757724648,0.000224221016154935,0.00681348606444975]
["Biological process","GO:0051402","neuron apoptotic process",6,4.72440944881889,4.23601460432834e-06,"APP, CASP7, BCL2, BCL2L1, GAPDH, ATM",126,33,16792,24.2308802308802,0.0080749699751903,0.000231623146214277,0.00724544074414135]
["Biological process","GO:0046777","protein autophosphorylation",10,7.87401574803149,5.56529775265002e-06,"AKT1, EGFR, IGF1R, FGFR1, NTRK1, GSK3B, KIT, MTOR, INSR, ATM",126,172,16792,7.74824658545588,0.0105954777894021,0.00029584538299332,0.00951899538705891]
["Biological process","GO:0043524","negative regulation of neuron apoptotic process",9,7.08661417322834,6.41070882317096e-06,"HSP90AB1, HRAS, BRAF, HDAC1, JUN, NTRK1, BCL2, BCL2L1, TERT",126,132,16792,9.08658008658008,0.0121951648474561,0.000331570316182805,0.0109649285638724]
["Biological process","GO:0033138","positive regulation of peptidyl-serine phosphorylation",7,5.51181102362204,1.33969086167839e-05,"AKT1, TNF, BRAF, BCL2, GSK3B, TGFB1, OPRD1",126,70,16792,13.3269841269841,0.0253158945126124,0.000674558037406014,0.0229128925652299]
["Biological process","GO:0042908","xenobiotic transport",4,3.14960629921259,1.3790696636068E-5,"NR1I2, SLC2A1, ABCB1, ABCG2",126,7,16792,76.1541950113378,0.0260502571315901,0.000676580640863955,0.0235863181209605]
["Biological process","GO:0045740","positive regulation of DNA replication",6,4.72440944881889,1.43910845164466e-05,"EGFR, CDK1, IGF1R, HRAS, JUN, INSR",126,42,16792,19.0385487528344,0.0271688370143142,0.00068838130590243,0.0246130464247817]
["Biological process","GO:0000187","activation of MAPK activity",8,6.29921259842519,1.50613309283219e-05,"MAPK1, CDK1, TNF, MAP2K1, MAPK3, KIT, INSR, PTPN11",126,107,16792,9.96410028185729,0.0284160532588464,7.02865179061151E-4,0.0257592286564301]
["Biological process","GO:1900034","regulation of cellular response to heat",7,5.51181102362204,1.99598406822704E-5,"HSP90AB1, MAPK1, HSP90AA1, GSK3B, MAPK3, MTOR, ATM",126,75,16792,12.4385185185185,0.0374829669824426,0.000909193964262922,0.0341357495502347]
["Biological process","GO:0000165","MAPK cascade",11,8.66141732283464,2.64745847930447e-05,"EGFR, MAPK1, FGFR1, HRAS, TNF, BRAF, MAP2K1, MAPK3, KIT, TGFB1, IL2",126,262,16792,5.59529867926814,0.0494105623128495,0.00117774837610529,0.0452750302094351]

{"sheet":"CC","index":1,"n_rows":21,"n_cols":14,"rows_kept":21}
["Supplementary Table 9. GO and KEGG pathway enrichment analyses for the CCMM-MI common targets"]
["Category","ID","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["Cellular component","GO:0005829","cytosol",52,40.9448818897637,{"v":4.02029273075887e-09,"d":"4.02E-09"},"HSP90AB1, NAMPT, HRAS, THRA, PGD, PPARG, NFKB1, AKT1, CSNK2A2, CCNE1, GSR, APP, CASP3, CASP7, SLC2A1, NOS3, NOS2, CDK1, AR, SGK1, HSP90AA1, BRAF, CFTR, CDK4, CDK2, MAPK1, CCND1, CCND2, GNB1, JUN, LCK, MAPK3, MDM2, MAPK8, XDH, FGFR1, BCL2L1, EPHB2, BCL2, FASN, GAPDH, HPGDS, GSTA1, MAP2K1, PTPN11, CCNB1, NR1I3, HSP90B1, HDAC1, GSK3B, FABP4, MTOR",127,3315,18224,2.2509186351706,{"v":9.20646621271892e-07,"d":"9.21E-07"},{"v":9.20646621271892e-07,"d":"9.21E-07"},{"v":5.15059739303325e-06,"d":"5.15E-06"}]
["Cellular component","GO:0005654","nucleoplasm",45,35.4330708661417,{"v":3.8075690365395e-08,"d":"3.81E-08"},"HSP90AB1, PPARA, NAMPT, THRA, THRB, PPARG, NFKB1, NR3C1, CSNK2A2, AKT1, PGR, CCNE1, KDM1A, CASP3, CASP7, CCNA2, DNMT3B, TERT, NR1H4, CDK1, DNMT3A, AR, SGK1, HSP90AA1, ESR1, NR4A1, ESR2, CDK4, AHR, ATM, CDK2, CCNB1, MAPK1, CCND1, NR1I3, NR1I2, HDAC1, CCND2, JUN, MAPK3, MDM2, MAPK8, MTOR, PARP1, SLC9A1",127,2784,18224,2.3194406733641,{"v":8.71929524937087e-06,"d":"8.72E-06"},{"v":4.35965712797248e-06,"d":"4.36E-06"},{"v":4.87806544269275e-05,"d":"4.88E-05"}]
["Cellular component","GO:0031090","organelle membrane",9,7.08661417322834,{"v":1.54429361183004e-07,"d":"1.54E-07"},"CYP3A4, CYP1B1, PTGS2, SQLE, FAAH, EPHX1, SRD5A1, SRD5A2, CYP1A2",127,87,18224,14.8444203095302,{"v":3.53637011322183e-05,"d":"3.54E-05"},{"v":1.17880393347702e-05,"d":"1.18E-05"},{"v":0.000197846974003823,"d":"1.98E-04"}]
["Cellular component","GO:0005634","nucleus",66,51.9685039370078,{"v":2.09461913696927e-07,"d":"2.09E-07"},"HSP90AB1, PPARA, HRAS, THRA, PTGS2, THRB, PPARG, PGD, NFKB1, MMP2, TGFB1, CSNK2A2, PGR, AKT1, KDM1A, CCNE1, CASP3, CASP7, NOS3, NOS2, CCNA2, TERT, EGFR, CDK1, AR, SGK1, HSP90AA1, BRAF, ESR1, ESR2, CDK4, CDK2, AHR, MAPK1, CCND1, CCND2, JUN, MAPK3, TNNI3K, MDM2, MAPK8, FGFR1, ACHE, NR3C1, BCL2, HSPA5, DNMT3B, GAPDH, NR1H4, DNMT3A, MAP2K1, NR4A1, ATM, PTPN11, ABCG2, CCNB1, HSP90B1, NR1I3, NR1I2, HDAC1, GSK3B, FABP4, MPO, MTOR, PARP1, IGFBP3",127,5415,18224,1.74898248522258,{"v":4.7965632873792E-5,"d":"4.80E-05"},{"v":1.19916239152972e-05,"d":"1.20E-05"},{"v":0.000268351769427965,"d":"2.68E-04"}]
["Cellular component","GO:0005789","endoplasmic reticulum membrane",22,17.3228346456692,{"v":4.49664431097463E-7,"d":"4.50E-07"},"EGFR, CYP3A4, SGK1, STS, CYP1B1, PTGS2, HMGCR, EPHX1, CYP1A2, GBA2, CYP17A1, HSP90B1, SQLE, BCL2, FAAH, HSD17B3, SRD5A1, HSPA5, MTOR, SRD5A2, SLC9A1, CYP19A1",127,862,18224,3.66231251256006,{"v":1.02967876325799E-4,"d":"1.03E-04"},{"v":2.05944235082133e-05,"d":"2.06E-05"},{"v":0.000576085993064801,"d":"5.76E-04"}]
["Cellular component","GO:0042470","melanosome",9,7.08661417322834,{"v":4.9271208488657e-07,"d":"4.93E-07"},"NCSTN, HSP90AB1, HSP90B1, HSP90AA1, SLC2A1, FASN, CTSD, HSPA5, CTSB",127,101,18224,12.7867778903874,{"v":1.12824730052252E-4,"d":"1.13E-04"},{"v":1.88050057238209E-5,"d":"1.88E-05"},{"v":0.000631236181725114,"d":"6.31E-04"}]
["Cellular component","GO:0070062","extracellular exosome",42,33.0708661417322,{"v":1.22063475642864e-06,"d":"1.22E-06"},"ALPL, HSP90AB1, NAMPT, THRB, MMP9, PGD, GSR, ACE, APP, ECE1, SLC2A1, SERPINE1, FASN, HSPA5, GAPDH, INSR, GBA, GSTA1, SHBG, ICAM1, CDK1, HSP90AA1, MAP2K1, PTPRF, CFTR, ABCB1, FUCA1, NCSTN, MAPK1, HSP90B1, GNB1, LCK, MAPK3, PON1, ALDH2, MPO, CTSD, FABP4, CTSB, IGFBP2, IGFBP3, SLC9A1",127,2811,18224,2.14401801695812,{"v":0.000279486466189915,"d":"2.79E-04"},{"v":3.99314212640167E-5,"d":"3.99E-05"},1.56380477391859E-3]
["Cellular component","GO:0043231","intracellular membrane-bounded organelle",17,13.3858267716535,{"v":1.53143023580447e-06,"d":"1.53E-06"},"CYP3A4, HRAS, STS, CYP1B1, BRAF, PPARG, CYP1A2, IGF1R, APP, SQLE, CASP7, PON1, HSD17B3, CTSB, DNMT3B, INSR, GAPDH",127,558,18224,4.37174385459882,{"v":0.000350636305260554,"d":"3.51E-04"},{"v":4.38362632309008E-5,"d":"4.38E-05"},0.00196197388737662]
["Cellular component","GO:0000307","cyclin-dependent protein kinase holoenzyme complex",5,3.93700787401574,{"v":2.80331574479374E-6,"d":"2.80E-06"},"CCNE1, CCND1, CCND2, CDK4, CDK2",127,15,18224,47.8320209973753,{"v":0.000641754192992505,"d":"6.42E-04"},{"v":7.13263678602249e-05,"d":"7.13E-05"},0.00359140811488911]
["Cellular component","GO:0016020","membrane",35,27.5590551181102,{"v":3.9882586427428e-06,"d":"3.99E-06"},"ALPL, HSP90AB1, ACHE, HRAS, TNF, GNRHR, BCL2L1, KIT, IGF1R, ACE, ECE1, BCHE, BCL2, SLC2A1, FASN, HSPA5, GAPDH, INSR, CYP19A1, EGFR, ICAM1, CDK1, STS, HSP90AA1, ESR1, CFTR, ABCB1, CCNB1, NCSTN, CCND1, HSP90B1, GNB1, ABCC4, MTOR, PARP1",127,2200,18224,2.28289191123836,{"v":0.000912896107042038,"d":"9.13E-04"},{"v":9.13271344696875e-05,"d":"9.13E-05"},0.00510943665418262]
["Cellular component","GO:0043234","protein complex",14,11.023622047244,{"v":5.64288672811681E-6,"d":"5.64E-06"},"AR, HSP90AA1, PTGS2, CFTR, NR3C1, PTPN11, AKT1, KDM1A, MAPK1, HDAC1, NTRK1, MAPK3, MDM2, PARP1",127,412,18224,4.87607981041204,0.00129139014385226,{"v":0.000117468073419946,"d":"1.17E-04"},0.00722914262306639]
["Cellular component","GO:0005886","plasma membrane",51,40.1574803149606,{"v":1.20940529682187E-5,"d":"1.21E-05"},"HRAS, GNRHR, MMP2, TGFB1, AKT1, APP, CASP3, SERPINE1, SLC2A1, NOS3, INSR, TERT, EGFR, ICAM1, AR, STS, SGK1, KCND3, HSP90AA1, BRAF, PTPRF, ESR1, CFTR, GNB1, LCK, MDM2, ALPL, FGFR1, ACHE, TNF, KIT, EPHB2, IGF1R, ACE, ECE1, CNR2, FASN, HSPA5, GAPDH, MAP2K1, ABCB1, ABCG2, NCSTN, GBA2, HSP90B1, NTRK1, GSK3B, ABCC4, ABCC2, SLC9A1, OPRD1",127,4121,18224,1.77585518383849,2.76572319837942E-3,{"v":0.000230769608373648,"d":"2.31E-04"},0.0154931876419572]
["Cellular component","GO:0005739","mitochondrion",25,19.6850393700787,{"v":1.23412781846702e-05,"d":"1.23E-05"},"HSP90AB1, CDK1, SGK1, CYP1B1, MAP2K1, BRAF, NFKB1, BCL2L1, ESR2, MMP2, PTPN11, AKT1, GSR, MAPK1, CYP17A1, BCL2, GSK3B, MAPK3, FASN, MPO, MAPK8, HSPA5, CTSB, PARP1, SLC9A1",127,1331,18224,2.69526789992723,2.82218028433212E-3,{"v":0.000217374074186538,"d":"2.17E-04"},0.0158098744891255]
["Cellular component","GO:0048471","perinuclear region of cytoplasm",16,12.5984251968503,{"v":2.5560752737499E-5,"d":"2.56E-05"},"EGFR, HRAS, ACHE, HSP90AA1, PPARG, CDK4, HSP90B1, APP, ECE1, HDAC1, GSK3B, SRD5A1, NOS2, CTSB, GAPDH, SLC9A1",127,621,18224,3.69716104327538,0.00583638890864057,{"v":0.00041801883341308,"d":"4.18E-04"},0.032742211882597]
["Cellular component","GO:0005615","extracellular space",24,18.8976377952755,{"v":4.54734424747813e-05,"d":"4.55E-05"},"ALPL, XDH, EGFR, ICAM1, NAMPT, ACHE, TNF, MMP9, KIT, MMP2, TGFB1, CTSK, APP, ACE, SERPINE1, PON1, CTSD, MPO, CTSB, IGFBP2, IGFBP3, ADAMTS5, GBA, IL2",127,1347,18224,2.55672272591761,0.0103596207223872,{"v":0.000694002742011479,"d":"6.94E-04"},0.0582426514747935]
["Cellular component","GO:0043025","neuronal cell body",11,8.66141732283464,{"v":6.77840784819188e-05,"d":"6.78E-05"},"CYP17A1, HSP90AA1, PTPRF, NTRK1, GSK3B, CNR2, SRD5A1, SRD5A2, MTOR, TGFB1, EPHB2",127,315,18224,5.01097362829646,0.0154032180900475,{"v":0.000969722020863983,"d":"9.70E-04"},0.0868068070898897]
["Cellular component","GO:0005901","caveola",6,4.72440944881889,{"v":8.64651297254111e-05,"d":"8.65E-05"},"MAPK1, PTGS2, MAPK3, SLC2A1, NOS3, INSR",127,65,18224,13.2457904300423,0.0196066112613125,1.16410841616854E-3,0.110718240260287]
["Cellular component","GO:0045121","membrane raft",9,7.08661417322834,{"v":9.34316552080931e-05,"d":"9.34E-05"},"EGFR, ICAM1, APP, CASP3, TNF, LCK, CTSD, SLC9A1, OPRD1",127,206,18224,6.26924547052977,0.0211695600370002,1.18800757236503E-3,0.119633925698403]
["Cellular component","GO:0009986","cell surface",14,11.023622047244,{"v":9.80408610915737e-05,"d":"9.80E-05"},"HSP90AB1, EGFR, ICAM1, ACHE, TNF, HSP90AA1, CFTR, ABCB1, TGFB1, APP, NTRK1, ABCC2, HSPA5, SLC9A1",127,542,18224,3.70654037249033,0.022202277293068,1.1810103649027E-3,0.125532335223677]

{"sheet":"MF","index":2,"n_rows":22,"n_cols":14,"rows_kept":22}
["Supplementary Table 9. GO and KEGG pathway enrichment analyses for the CCMM-MI common targets"]
["Category","ID","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["Molecular function","GO:0019899","enzyme binding",23,18.1102362204724,4.98345624920191E-15,"EGFR, CYP3A4, AR, THRB, PTGS2, PPARG, ESR1, CFTR, CYP1A2, ESR2, TGFB1, PGR, AKT1, KDM1A, CCND1, APP, HDAC1, BCHE, JUN, MDM2, MAPK8, HSPA5, PARP1",127,333,16881,9.18074767681067,2.36810571152545E-12,2.36810571152545E-12,7.13873404833975e-12]
["Molecular function","GO:0003707","steroid hormone receptor activity",13,10.2362204724409,7.46332465706867e-15,"PPARA, AR, THRA, THRB, PPARG, ESR1, NR4A1, NR3C1, ESR2, PGR, NR1I3, NR1I2, NR1H4",127,56,16881,30.8567210348706,3.52584628160457e-12,1.76292314080228E-12,1.0635936575909E-11]
["Molecular function","GO:0004879","RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding",10,7.87401574803149,4.27658884026955e-12,"PPARA, AR, NR1I3, NR1I2, PPARG, ESR1, NR4A1, ESR2, AHR, NR1H4",127,36,16881,36.9225721784776,2.02709848906579e-09,6.75699496355264e-10,6.11219963531084e-09]
["Molecular function","GO:0042802","identical protein binding",24,18.8976377952755,6.69152167187405e-09,"EGFR, DNMT3A, FGFR1, TNF, HSP90AA1, BRAF, MMP9, PPARG, ESR1, NFKB1, BCL2L1, EPHB2, AKT1, IGF1R, MAPK1, APP, BCHE, JUN, BCL2, LCK, SLC2A1, MDM2, PARP1, GAPDH",127,749,16881,4.25915919388581,3.17177625219766e-06,7.92945006211631e-07,9.56369778926102e-06]
["Molecular function","GO:0005515","protein binding",97,76.3779527559055,1.88513898808033E-8,"HRAS, THRA, PTGS2, THRB, HMGCR, MMP9, MMP2, TGFB1, PGR, CSNK2A2, KDM1A, APP, SERPINE1, SLC2A1, INSR, CCNA2, EGFR, KCND3, BRAF, AHR, MAPK1, JUN, MAPK3, MAPK8, ADAMTS5, FGFR1, ACHE, BCL2L1, EPHB2, ECE1, CTRC, DNMT3B, NR1H4, DNMT3A, MAP2K1, NR4A1, ABCB1, ATM, PTPN11, ABCG2, NR1I2, HDAC1, NTRK1, FAAH, MTOR, PARP1, SLC9A1, HSP90AB1, PPARA, NAMPT, PPARG, NFKB1, AKT1, CCNE1, CASP3, CASP7, NOS3, NOS2, TERT, CDK1, ICAM1, SGK1, AR, HSP90AA1, ESR1, CFTR, ESR2, CDK4, CDK2, CTSK, CCND1, CCND2, GNB1, LCK, CTSD, MDM2, TNNI3K, CTSB, ALPL, TNF, NR3C1, KIT, IGF1R, BCL2, FASN, HSPA5, GAPDH, HPGDS, GBA, CCNB1, NCSTN, HSP90B1, GSK3B, ABCC2, IGFBP2, IGFBP3, OPRD1",127,8785,16881,1.46765648317864,8.93551897174216e-06,1.78711018183896e-06,2.69428973243002e-05]
["Molecular function","GO:0005496","steroid binding",7,5.51181102362204,3.99336650816842e-08,"SHBG, PGR, CYP3A4, AR, ESR1, NR3C1, ESR2",127,27,16881,34.4610673665791,1.89283784635119e-05,3.15475462497882e-06,5.7074225956466e-05]
["Molecular function","GO:0005524","ATP binding",32,25.1968503937007,1.16964666474628E-7,"HSP90AB1, FGFR1, KIT, EPHB2, AKT1, CSNK2A2, IGF1R, HSPA5, INSR, EGFR, CDK1, SGK1, HSP90AA1, MAP2K1, BRAF, CFTR, ABCB1, CDK4, ATM, CDK2, ABCG2, MAPK1, HSP90B1, GSK3B, NTRK1, LCK, MAPK3, TNNI3K, ABCC4, MAPK8, ABCC2, MTOR",127,1495,16881,2.84513733442182,5.54397183289978e-05,7.9201479450397E-6,1.67168838138831E-4]
["Molecular function","GO:0004887","thyroid hormone receptor activity",5,3.93700787401574,2.02392643978114E-7,"NR1I3, NR1I2, THRA, THRB, NR1H4",127,8,16881,83.0757874015748,9.59295214227884e-05,1.19916934682162E-5,0.000289264484243378]
["Molecular function","GO:0030235","nitric-oxide synthase regulator activity",5,3.93700787401574,2.02392643978114E-7,"HSP90AB1, AKT1, EGFR, HSP90AA1, ESR1",127,8,16881,83.0757874015748,9.59295214227884e-05,1.19916934682162E-5,0.000289264484243378]
["Molecular function","GO:0008134","transcription factor binding",14,11.023622047244,2.05957963208295e-07,"PPARA, AR, THRA, PPARG, ESR1, NFKB1, AHR, KDM1A, MAPK1, CCND1, HDAC1, BCL2, JUN, PARP1",127,284,16881,6.55245647111012,9.76193195528773e-05,1.08470616845268E-5,0.000294360118180403]
["Molecular function","GO:0042803","protein homodimerization activity",21,16.5354330708661,4.57218430960221e-07,"XDH, NAMPT, FGFR1, ACHE, HSP90AA1, PTGS2, HMGCR, NFKB1, BCL2L1, KIT, TGFB1, ABCG2, ECE1, JUN, BCL2, NTRK1, PON1, FASN, NOS2, HPGDS, TERT",127,730,16881,3.82376226944234,2.16698103414292E-4,2.16719237445817e-05,6.53466583755424E-4]
["Molecular function","GO:0004674","protein serine/threonine kinase activity",15,11.8110236220472,8.36624618185322e-07,"CDK1, SGK1, MAP2K1, BRAF, CDK4, CDK2, ATM, AKT1, CSNK2A2, MAPK1, GSK3B, MAPK3, TNNI3K, MAPK8, MTOR",127,376,16881,5.30270983414307,0.000396481615266841,3.60502806170393e-05,0.00119571919123817]
["Molecular function","GO:0004713","protein tyrosine kinase activity",9,7.08661417322834,6.92147392742299e-06,"EGFR, IGF1R, FGFR1, HSP90AA1, MAP2K1, LCK, KIT, INSR, EPHB2",127,133,16881,8.99467171866674,3.27541408476128E-3,0.00027336179615145,0.00989189696686265]
["Molecular function","GO:0020037","heme binding",9,7.08661417322834,8.61257310669526e-06,"CYP3A4, CYP17A1, CYP1B1, PTGS2, MPO, NOS3, CYP1A2, NOS2, CYP19A1",127,137,16881,8.73205356629691,0.00407405565833562,0.000313979715932166,0.0123086107345238]
["Molecular function","GO:0008144","drug binding",7,5.51181102362204,2.18819454727934e-05,"HSP90AB1, PPARA, NAMPT, ACE, NR1I2, PPARG, FASN",127,76,16881,12.2427476170741,0.0103185503240252,0.000740593884587914,0.0312697023806318]
["Molecular function","GO:0019901","protein kinase binding",13,10.2362204724409,2.48858754563821e-05,"CCNB1, HSP90AB1, EGFR, CCNE1, CCND1, MAP2K1, CCND2, GSK3B, LCK, BCL2L1, MTOR, PARP1, CCNA2",127,376,16881,4.59568185625732,0.0117267510851135,0.000786094315477603,0.0355616636017686]
["Molecular function","GO:0043565","sequence-specific DNA binding",15,11.8110236220472,3.25763468376875e-05,"PPARA, AR, THRA, THRB, PPARG, ESR1, NR4A1, NR3C1, ESR2, PGR, NR1I3, NR1I2, JUN, BCL2, NR1H4",127,518,16881,3.84907123096099,0.0153228321582531,0.000964624445135231,0.046548890042608]
["Molecular function","GO:0004672","protein kinase activity",12,9.44881889763779,7.91642049173865e-05,"CSNK2A2, AKT1, EGFR, CDK1, CCND1, BRAF, MAP2K1, GSK3B, TNNI3K, MTOR, CDK4, CDK2",127,359,16881,4.44305046827363,0.0368299685904509,0.00220493722209924,0.113084047728262]
["Molecular function","GO:0016301","kinase activity",10,7.87401574803149,8.19940975612646e-05,"AKT1, MAPK1, CCNE1, BRAF, GSK3B, MAPK3, LCK, MAPK8, MTOR, CDK2",127,241,16881,5.51540497271865,0.0381211729810379,0.00215693688845564,0.117124274596658]
["Molecular function","GO:0031994","insulin-like growth factor I binding",4,3.14960629921259,8.50379990601223e-05,"IGF1R, IGFBP2, IGFBP3, INSR",127,12,16881,44.3070866141732,0.0395080957653348,0.0021193155731517,0.121469871425428]

{"sheet":"KEGG","index":3,"n_rows":62,"n_cols":14,"rows_kept":62}
["Supplementary Table 9. GO and KEGG pathway enrichment analyses for the CCMM-MI common targets"]
["Category","ID","Term","Count","%","PValue","Genes","List Total","Pop Hits","Pop Total","Fold Enrichment","Bonferroni","Benjamini","FDR"]
["KEGG pathway","hsa05215","Prostate cancer",22,17.3228346456692,{"v":1.91477686906369e-19,"d":"1.91E-19"},"EGFR, HSP90AB1, FGFR1, AR, HRAS, HSP90AA1, MAP2K1, BRAF, NFKB1, CDK2, AKT1, CCNE1, IGF1R, MAPK1, CCND1, HSP90B1, BCL2, GSK3B, MAPK3, MDM2, MTOR, SRD5A2",114,88,6879,15.0855263157894,{"v":3.98273588765247e-17,"d":"3.98E-17"},{"v":3.98273588765247e-17,"d":"3.98E-17"},{"v":2.41538185161632e-16,"d":"2.42E-16"}]
["KEGG pathway","hsa05200","Pathways in cancer",37,29.1338582677165,{"v":2.41506600100007e-18,"d":"2.42E-18"},"HSP90AB1, FGFR1, HRAS, PTGS2, MMP9, PPARG, NFKB1, BCL2L1, KIT, MMP2, TGFB1, AKT1, CCNE1, IGF1R, CASP3, BCL2, SLC2A1, NOS2, EGFR, AR, HSP90AA1, MAP2K1, BRAF, CDK4, CDK2, MAPK1, CCND1, HSP90B1, HDAC1, GNB1, JUN, GSK3B, NTRK1, MAPK3, MDM2, MAPK8, MTOR",114,393,6879,5.68106334538636,{"v":5.02333728208015e-16,"d":"5.02E-16"},{"v":2.51166864104007e-16,"d":"2.51E-16"},{"v":3.04646806816902e-15,"d":"3.05E-15"}]
["KEGG pathway","hsa04151","PI3K-Akt signaling pathway",29,22.8346456692913,{"v":7.32425477405555e-13,"d":"7.32E-13"},"HSP90AB1, FGFR1, HRAS, NFKB1, BCL2L1, KIT, AKT1, CCNE1, IGF1R, BCL2, NOS3, INSR, EGFR, SGK1, HSP90AA1, MAP2K1, NR4A1, CDK4, CDK2, MAPK1, CCND1, HSP90B1, CCND2, GNB1, GSK3B, MAPK3, MDM2, MTOR, IL2",114,345,6879,5.07223493516399,{"v":1.52342138903804E-10,"d":"1.52E-10"},{"v":5.07807129679349e-11,"d":"5.08E-11"},{"v":9.23894294402316E-10,"d":"9.24E-10"}]
["KEGG pathway","hsa04068","FoxO signaling pathway",18,14.1732283464566,{"v":3.91642085737089e-11,"d":"3.92E-11"},"EGFR, HRAS, SGK1, MAP2K1, BRAF, CDK2, ATM, TGFB1, AKT1, CCNB1, IGF1R, MAPK1, CCND1, CCND2, MAPK3, MDM2, MAPK8, INSR",114,134,6879,8.10565593087195,{"v":8.14615930266882e-09,"d":"8.15E-09"},{"v":2.0365398256672e-09,"d":"2.04E-09"},{"v":4.94034368969664e-08,"d":"4.94E-08"}]
["KEGG pathway","hsa05220","Chronic myeloid leukemia",14,11.023622047244,{"v":9.92617905583689e-11,"d":"9.93E-11"},"AKT1, MAPK1, HRAS, CCND1, HDAC1, MAP2K1, BRAF, MAPK3, MDM2, NFKB1, BCL2L1, CDK4, TGFB1, PTPN11",114,72,6879,11.7331871345029,{"v":2.06464585428278E-8,"d":"2.06E-08"},{"v":4.12929179738341e-09,"d":"4.13E-09"},{"v":1.25213128754353E-7,"d":"1.25E-07"}]
["KEGG pathway","hsa05161","Hepatitis B",18,14.1732283464566,{"v":1.4042121522742E-10,"d":"1.40E-10"},"HRAS, TNF, MAP2K1, MMP9, NFKB1, CDK4, CDK2, TGFB1, AKT1, CCNE1, MAPK1, CASP3, CCND1, JUN, BCL2, MAPK3, MAPK8, CCNA2",114,145,6879,7.49074410163339,{"v":2.92076154373432E-8,"d":"2.92E-08"},{"v":4.86793594323131e-09,"d":"4.87E-09"},{"v":1.77133374634763e-07,"d":"1.77E-07"}]
["KEGG pathway","hsa04066","HIF-1 signaling pathway",15,11.8110236220472,{"v":3.57976217262513e-10,"d":"3.58E-10"},"EGFR, MAP2K1, NFKB1, AKT1, IGF1R, MAPK1, BCL2, SERPINE1, MAPK3, SLC2A1, NOS3, NOS2, MTOR, INSR, GAPDH",114,96,6879,9.42845394736842,{"v":7.44590477053108E-8,"d":"7.45E-08"},{"v":1.06370071639716e-08,"d":"1.06E-08"},{"v":4.51566573023143e-07,"d":"4.52E-07"}]
["KEGG pathway","hsa05205","Proteoglycans in cancer",20,15.7480314960629,{"v":4.18265915434407e-10,"d":"4.18E-10"},"EGFR, FGFR1, HRAS, TNF, BRAF, MAP2K1, MMP9, ESR1, MMP2, TGFB1, PTPN11, AKT1, IGF1R, MAPK1, CASP3, CCND1, MAPK3, MDM2, MTOR, SLC9A1",114,200,6879,6.03421052631578,{"v":8.69992964336319e-08,"d":"8.70E-08"},{"v":1.08749124150264e-08,"d":"1.09E-08"},{"v":5.27618537748963e-07,"d":"5.28E-07"}]
["KEGG pathway","hsa04915","Estrogen signaling pathway",15,11.8110236220472,{"v":5.4569589421224e-10,"d":"5.46E-10"},"HSP90AB1, EGFR, HRAS, HSP90AA1, MAP2K1, MMP9, ESR1, ESR2, MMP2, AKT1, MAPK1, HSP90B1, JUN, MAPK3, NOS3",114,99,6879,9.14274322169059,{"v":1.13504747600856e-07,"d":"1.14E-07"},{"v":1.26116392884512E-8,"d":"1.26E-08"},{"v":6.88364309997524e-07,"d":"6.88E-07"}]
["KEGG pathway","hsa05219","Bladder cancer",11,8.66141732283464,{"v":7.0012694161612E-10,"d":"7.00E-10"},"EGFR, MAPK1, HRAS, CCND1, BRAF, MAP2K1, MMP9, MAPK3, MDM2, CDK4, MMP2",114,41,6879,16.1893453145057,{"v":1.45626396386155e-07,"d":"1.46E-07"},{"v":1.45626405378962E-8,"d":"1.46E-08"},{"v":8.83170236942731e-07,"d":"8.83E-07"}]
["KEGG pathway","hsa04914","Progesterone-mediated oocyte maturation",14,11.023622047244,{"v":1.16685503294369E-9,"d":"1.17E-09"},"HSP90AB1, CDK1, HSP90AA1, BRAF, MAP2K1, CDK2, PGR, AKT1, CCNB1, IGF1R, MAPK1, MAPK3, MAPK8, CCNA2",114,87,6879,9.71022383545069,{"v":2.42705822550703e-07,"d":"2.43E-07"},{"v":2.2064168159197e-08,"d":"2.21E-08"},{"v":1.47192111832339E-6,"d":"1.47E-06"}]
["KEGG pathway","hsa04917","Prolactin signaling pathway",13,10.2362204724409,{"v":1.21508723948451E-9,"d":"1.22E-09"},"AKT1, MAPK1, CYP17A1, HRAS, CCND1, MAP2K1, CCND2, GSK3B, MAPK3, ESR1, NFKB1, MAPK8, ESR2",114,71,6879,11.0485544848035,{"v":2.52738116879314e-07,"d":"2.53E-07"},{"v":2.10615122009372e-08,"d":"2.11E-08"},{"v":1.53276328296314E-6,"d":"1.53E-06"}]
["KEGG pathway","hsa05210","Colorectal cancer",12,9.44881889763779,{"v":3.61856970591211e-09,"d":"3.62E-09"},"AKT1, MAPK1, CASP3, CCND1, BRAF, MAP2K1, JUN, BCL2, GSK3B, MAPK3, MAPK8, TGFB1",114,62,6879,11.6791171477079,{"v":7.52662208669541e-07,"d":"7.53E-07"},{"v":5.78971131037775e-08,"d":"5.79E-08"},{"v":4.5646192270432e-06,"d":"4.56E-06"}]
["KEGG pathway","hsa04919","Thyroid hormone signaling pathway",15,11.8110236220472,{"v":4.10946395665545e-09,"d":"4.11E-09"},"HRAS, THRA, MAP2K1, THRB, ESR1, AKT1, MAPK1, CCND1, HDAC1, GSK3B, SLC2A1, MAPK3, MDM2, MTOR, SLC9A1",114,115,6879,7.87070938215102,{"v":8.54768146596462e-07,"d":"8.55E-07"},{"v":6.10548918089648E-8,"d":"6.11E-08"},{"v":5.18385440129165e-06,"d":"5.18E-06"}]
["KEGG pathway","hsa05214","Glioma",12,9.44881889763779,{"v":6.11517249664223e-09,"d":"6.12E-09"},"AKT1, EGFR, MAPK1, IGF1R, HRAS, CCND1, BRAF, MAP2K1, MAPK3, MDM2, MTOR, CDK4",114,65,6879,11.1400809716599,{"v":1.27195507071409E-6,"d":"1.27E-06"},{"v":8.47970550443832e-08,"d":"8.48E-08"},{"v":7.71394116361179e-06,"d":"7.71E-06"}]
["KEGG pathway","hsa05212","Pancreatic cancer",12,9.44881889763779,{"v":6.11517249664223e-09,"d":"6.12E-09"},"AKT1, EGFR, MAPK1, CCND1, BRAF, MAP2K1, MAPK3, NFKB1, MAPK8, BCL2L1, CDK4, TGFB1",114,65,6879,11.1400809716599,{"v":1.27195507071409E-6,"d":"1.27E-06"},{"v":8.47970550443832e-08,"d":"8.48E-08"},{"v":7.71394116361179e-06,"d":"7.71E-06"}]
["KEGG pathway","hsa04115","p53 signaling pathway",12,9.44881889763779,{"v":8.54180936553121e-09,"d":"8.54E-09"},"CCNB1, CCNE1, CDK1, CASP3, CCND1, CCND2, SERPINE1, MDM2, CDK4, IGFBP3, ATM, CDK2",114,67,6879,10.8075412411626,{"v":1.77669477841035E-6,"d":"1.78E-06"},{"v":1.1104351615998E-7,"d":"1.11E-07"},{"v":1.07750049882504e-05,"d":"1.08E-05"}]
["KEGG pathway","hsa05218","Melanoma",12,9.44881889763779,{"v":1.61102628815906e-08,"d":"1.61E-08"},"AKT1, EGFR, MAPK1, IGF1R, FGFR1, HRAS, CCND1, BRAF, MAP2K1, MAPK3, MDM2, CDK4",114,71,6879,10.1986656782802,{"v":3.35092909609091E-6,"d":"3.35E-06"},{"v":1.97113787070435e-07,"d":"1.97E-07"},{"v":2.03221762418159E-5,"d":"2.03E-05"}]
["KEGG pathway","hsa05230","Central carbon metabolism in cancer",11,8.66141732283464,{"v":6.89758419738146e-08,"d":"6.90E-08"},"AKT1, EGFR, MAPK1, FGFR1, HRAS, MAP2K1, NTRK1, MAPK3, SLC2A1, KIT, MTOR",114,64,6879,10.3712993421052,{"v":1.43468726983009E-5,"d":"1.43E-05"},{"v":7.97053883228038e-07,"d":"7.97E-07"},{"v":8.7009057159193e-05,"d":"8.70E-05"}]
["KEGG pathway","hsa04668","TNF signaling pathway",13,10.2362204724409,{"v":1.43569081640949e-07,"d":"1.44E-07"},"AKT1, ICAM1, MAPK1, CASP3, TNF, PTGS2, MAP2K1, CASP7, JUN, MMP9, MAPK3, NFKB1, MAPK8",114,107,6879,7.33128381701918,{"v":2.98619252451226e-05,"d":"2.99E-05"},{"v":1.57170250814075e-06,"d":"1.57E-06"},{"v":1.81104060059666E-4,"d":"1.81E-04"}]
["KEGG pathway","hsa05221","Acute myeloid leukemia",10,7.87401574803149,{"v":2.51071094402398e-07,"d":"2.51E-07"},"AKT1, MAPK1, HRAS, CCND1, BRAF, MAP2K1, MAPK3, NFKB1, KIT, MTOR",114,56,6879,10.7753759398496,{"v":5.22214305961332e-05,"d":"5.22E-05"},{"v":2.61113630006804e-06,"d":"2.61E-06"},{"v":0.000316711409242831,"d":"3.17E-04"}]
["KEGG pathway","hsa05216","Thyroid cancer",8,6.29921259842519,{"v":3.10120562223263e-07,"d":"3.10E-07"},"MAPK1, HRAS, CCND1, BRAF, MAP2K1, NTRK1, MAPK3, PPARG",114,29,6879,16.6460980036297,{"v":6.45030065377083e-05,"d":"6.45E-05"},{"v":3.07166608937148e-06,"d":"3.07E-06"},{"v":3.91198703575401E-4,"d":"3.91E-04"}]
["KEGG pathway","hsa04722","Neurotrophin signaling pathway",13,10.2362204724409,{"v":5.10809388517336e-07,"d":"5.11E-07"},"HRAS, BRAF, MAP2K1, NFKB1, PTPN11, AKT1, MAPK1, NTRK1, GSK3B, BCL2, JUN, MAPK3, MAPK8",114,120,6879,6.53706140350877,{"v":0.000106242735798733,"d":"1.06E-04"},{"v":4.82946015434304e-06,"d":"4.83E-06"},{"v":0.000644355009082886,"d":"6.44E-04"}]
["KEGG pathway","hsa04660","T cell receptor signaling pathway",12,9.44881889763779,{"v":5.98285812221612e-07,"d":"5.98E-07"},"AKT1, MAPK1, HRAS, TNF, MAP2K1, JUN, GSK3B, MAPK3, LCK, NFKB1, CDK4, IL2",114,100,6879,7.24105263157894,{"v":1.2443574339982E-4,"d":"1.24E-04"},{"v":5.41057171798975e-06,"d":"5.41E-06"},{"v":0.000754700819460829,"d":"7.55E-04"}]
["KEGG pathway","hsa04110","Cell cycle",13,10.2362204724409,{"v":7.30316301904696e-07,"d":"7.30E-07"},"CDK1, CDK4, CDK2, ATM, TGFB1, CCNB1, CCNE1, CCND1, HDAC1, CCND2, GSK3B, MDM2, CCNA2",114,124,6879,6.32618845500848,{"v":0.000151894309151412,"d":"1.52E-04"},{"v":6.3293902301531e-06,"d":"6.33E-06"},{"v":0.000921248469598623,"d":"9.21E-04"}]
["KEGG pathway","hsa05142","Chagas disease (American trypanosomiasis)",12,9.44881889763779,{"v":8.91814360644754e-07,"d":"8.92E-07"},"AKT1, MAPK1, ACE, TNF, JUN, MAPK3, SERPINE1, NFKB1, MAPK8, NOS2, TGFB1, IL2",114,104,6879,6.96255060728744,{"v":1.85480266146842E-4,"d":"1.85E-04"},{"v":7.41987126218202e-06,"d":"7.42E-06"},0.00112496714411713]
["KEGG pathway","hsa05211","Renal cell carcinoma",10,7.87401574803149,{"v":1.06954967397193E-6,"d":"1.07E-06"},"AKT1, MAPK1, HRAS, BRAF, MAP2K1, JUN, MAPK3, SLC2A1, TGFB1, PTPN11",114,66,6879,9.14274322169058,{"v":0.000222441707322551,"d":"2.22E-04"},{"v":8.55636536134518e-06,"d":"8.56E-06"},1.34916755474279E-3]
["KEGG pathway","hsa04931","Insulin resistance",12,9.44881889763779,{"v":1.30559830674464E-6,"d":"1.31E-06"},"AKT1, PPARA, TNF, PTPRF, GSK3B, SLC2A1, NFKB1, MAPK8, NOS3, MTOR, INSR, PTPN11",114,108,6879,6.70467836257309,{"v":0.000271527754756473,"d":"2.72E-04"},{"v":1.00578984965071E-5,"d":"1.01E-05"},1.64692534005972E-3]
["KEGG pathway","hsa04012","ErbB signaling pathway",11,8.66141732283464,{"v":1.32838281120942e-06,"d":"1.33E-06"},"AKT1, EGFR, MAPK1, HRAS, BRAF, MAP2K1, JUN, GSK3B, MAPK3, MAPK8, MTOR",114,87,6879,7.62946158499697,{"v":0.000276265639865269,"d":"2.76E-04"},{"v":9.86794446322658e-06,"d":"9.87E-06"},0.00167566625369763]
["KEGG pathway","hsa04976","Bile secretion",10,7.87401574803149,{"v":1.57162247528483e-06,"d":"1.57E-06"},"HMGCR, SLC2A1, EPHX1, ABCC4, ABCB1, CFTR, ABCC2, NR1H4, SLC9A1, ABCG2",114,69,6879,8.74523264683447,{"v":0.000326844306494655,"d":"3.27E-04"},{"v":1.12722720445601E-5,"d":"1.13E-05"},0.0019824940545976]
["KEGG pathway","hsa05213","Endometrial cancer",9,7.08661417322834,{"v":1.70439352708538e-06,"d":"1.70E-06"},"AKT1, EGFR, MAPK1, HRAS, CCND1, BRAF, MAP2K1, GSK3B, MAPK3",114,52,6879,10.4438259109311,{"v":0.0003544513230328,"d":"3.54E-04"},{"v":1.18170687029017e-05,"d":"1.18E-05"},0.00214997398042537]
["KEGG pathway","hsa05223","Non-small cell lung cancer",9,7.08661417322834,{"v":3.04634195465679e-06,"d":"3.05E-06"},"AKT1, EGFR, MAPK1, HRAS, CCND1, BRAF, MAP2K1, MAPK3, CDK4",114,56,6879,9.69783834586466,{"v":0.000633439384230327,"d":"6.33E-04"},{"v":2.04397940631873E-5,"d":"2.04E-05"},0.00384271871122221]
["KEGG pathway","hsa05166","HTLV-I infection",17,13.3858267716535,{"v":3.32372338700228e-06,"d":"3.32E-06"},"ICAM1, HRAS, TNF, NFKB1, BCL2L1, CDK4, ATM, TGFB1, AKT1, CCND1, CCND2, JUN, GSK3B, LCK, SLC2A1, TERT, IL2",114,254,6879,4.03864484044757,{"v":0.000691096695988102,"d":"6.91E-04"},{"v":2.16040045486476E-5,"d":"2.16E-05"},0.00419260663001574]
["KEGG pathway","hsa05206","MicroRNAs in cancer",18,14.1732283464566,{"v":3.51875990083181E-6,"d":"3.52E-06"},"EGFR, DNMT3A, HRAS, CYP1B1, PTGS2, MAP2K1, MMP9, NFKB1, ABCB1, ATM, CCNE1, CASP3, CCND1, CCND2, BCL2, MDM2, MTOR, DNMT3B",114,286,6879,3.79775487670224,{"v":0.000731635571138977,"d":"7.32E-04"},{"v":2.21786433550752e-05,"d":"2.22E-05"},0.00443862429653219]
["KEGG pathway","hsa04071","Sphingolipid signaling pathway",12,9.44881889763779,{"v":3.72473284277209E-6,"d":"3.72E-06"},"AKT1, MAPK1, HRAS, TNF, MAP2K1, BCL2, MAPK3, CTSD, NFKB1, MAPK8, NOS3, OPRD1",114,120,6879,6.03421052631579,{"v":0.000774445836073778,"d":"7.74E-04"},{"v":2.27863837443109E-5,"d":"2.28E-05"},4.69843649048007E-3]
["KEGG pathway","hsa00140","Steroid hormone biosynthesis",9,7.08661417322834,{"v":4.00006150054728e-06,"d":"4.00E-06"},"CYP3A4, CYP17A1, STS, CYP1B1, SRD5A1, HSD17B3, SRD5A2, CYP1A2, CYP19A1",114,58,6879,9.36343012704174,{"v":0.000831668428123322,"d":"8.32E-04"},{"v":2.37715590570841e-05,"d":"2.38E-05"},0.00504573231480121]
["KEGG pathway","hsa05203","Viral carcinogenesis",15,11.8110236220472,{"v":5.68240996897834e-06,"d":"5.68E-06"},"CDK1, HRAS, NFKB1, CDK4, CDK2, CCNE1, MAPK1, CCND1, CASP3, HDAC1, CCND2, JUN, MAPK3, MDM2, CCNA2",114,205,6879,4.41527599486521,1.18124641026151E-3,{"v":3.28312563676602e-05,"d":"3.28E-05"},0.0071677996670183]
["KEGG pathway","hsa04210","Apoptosis",9,7.08661417322834,{"v":6.68121693486319e-06,"d":"6.68E-06"},"AKT1, CASP3, TNF, CASP7, NTRK1, BCL2, NFKB1, BCL2L1, ATM",114,62,6879,8.75933786078098,0.00138873258209915,{"v":3.7558693705475e-05,"d":"3.76E-05"},0.00842764725023093]
["KEGG pathway","hsa04380","Osteoclast differentiation",12,9.44881889763779,{"v":8.75246180604599e-06,"d":"8.75E-06"},"AKT1, MAPK1, CTSK, TNF, MAP2K1, JUN, MAPK3, LCK, PPARG, NFKB1, MAPK8, TGFB1",114,131,6879,5.52752109280835,0.00181886388128393,{"v":4.79072740597885e-05,"d":"4.79E-05"},0.0110401704026763]
["KEGG pathway","hsa05222","Small cell lung cancer",10,7.87401574803149,{"v":9.17064887403687e-06,"d":"9.17E-06"},"AKT1, CCNE1, CCND1, PTGS2, BCL2, NFKB1, BCL2L1, NOS2, CDK4, CDK2",114,85,6879,7.09907120743034,1.90568558334969E-3,{"v":4.89091555068155e-05,"d":"4.89E-05"},0.0115676346431392]
["KEGG pathway","hsa05145","Toxoplasmosis",11,8.66141732283464,{"v":1.13545360539511e-05,"d":"1.14E-05"},"AKT1, MAPK1, CASP3, TNF, BCL2, MAPK3, NFKB1, MAPK8, BCL2L1, NOS2, TGFB1",114,110,6879,6.03421052631579,2.35897015403696E-3,{"v":5.90421796312634e-05,"d":"5.90E-05"},0.014322155464852]
["KEGG pathway","hsa04910","Insulin signaling pathway",12,9.44881889763779,{"v":1.44140421160768E-5,"d":"1.44E-05"},"AKT1, MAPK1, HRAS, BRAF, PTPRF, MAP2K1, GSK3B, MAPK3, FASN, MAPK8, MTOR, INSR",114,138,6879,5.24713958810068,2.9936524273294E-3,{"v":7.31227500081477e-05,"d":"7.31E-05"},0.0181809704342228]
["KEGG pathway","hsa04010","MAPK signaling pathway",16,12.5984251968503,{"v":1.44188830169616E-5,"d":"1.44E-05"},"EGFR, FGFR1, HRAS, TNF, BRAF, MAP2K1, NR4A1, NFKB1, TGFB1, AKT1, MAPK1, CASP3, JUN, NTRK1, MAPK3, MAPK8",114,253,6879,3.81610151861868,0.00299465633435369,{"v":7.14057669102263e-05,"d":"7.14E-05"},0.0181870759323188]
["KEGG pathway","hsa04014","Ras signaling pathway",15,11.8110236220472,{"v":1.74195132460283e-05,"d":"1.74E-05"},"EGFR, FGFR1, HRAS, MAP2K1, NFKB1, BCL2L1, KIT, PTPN11, AKT1, IGF1R, MAPK1, GNB1, MAPK3, MAPK8, INSR",114,226,6879,4.00500698649278,0.00361673411762863,{"v":8.42590154341849e-05,"d":"8.43E-05"},0.0219715001075648]
["KEGG pathway","hsa05133","Pertussis",9,7.08661417322834,{"v":2.79244570619405E-5,"d":"2.79E-05"},"MAPK1, CASP3, TNF, CASP7, JUN, MAPK3, NFKB1, MAPK8, NOS2",114,75,6879,7.24105263157894,0.00579153220888739,{"v":0.000131999654711001,"d":"1.32E-04"},0.0352193988474747]
["KEGG pathway","hsa04510","Focal adhesion",14,11.023622047244,{"v":2.92592659378923e-05,"d":"2.93E-05"},"EGFR, HRAS, BRAF, MAP2K1, AKT1, IGF1R, MAPK1, CCND1, CCND2, JUN, GSK3B, BCL2, MAPK3, MAPK8",114,206,6879,4.10091977516607,0.006067534067686,{"v":0.000135235662648836,"d":"1.35E-04"},0.0369026250785164]
["KEGG pathway","hsa05160","Hepatitis C",11,8.66141732283464,{"v":5.95771982887108e-05,"d":"5.96E-05"},"AKT1, EGFR, MAPK1, PPARA, HRAS, TNF, BRAF, GSK3B, MAPK3, NFKB1, MAPK8",114,133,6879,4.99070043529877,0.0123159564932092,{"v":0.000269364288853157,"d":"2.69E-04"},0.0751272430619454]
["KEGG pathway","hsa04114","Oocyte meiosis",10,7.87401574803149,{"v":7.88451528121435e-05,"d":"7.88E-05"},"CCNB1, PGR, MAPK1, CCNE1, CDK1, IGF1R, AR, MAP2K1, MAPK3, CDK2",114,111,6879,5.43622569938359,0.0162666833637337,{"v":0.000348884622216827,"d":"3.49E-04"},0.0994131384986496]
["KEGG pathway","hsa04064","NF-kappa B signaling pathway",9,7.08661417322834,{"v":8.21366245586217e-05,"d":"8.21E-05"},"CSNK2A2, ICAM1, TNF, PTGS2, BCL2, LCK, NFKB1, BCL2L1, ATM",114,87,6879,6.24228675136116,0.0169399965760052,{"v":0.000355876652018527,"d":"3.56E-04"},0.103561262580553]
["KEGG pathway","hsa05202","Transcriptional misregulation in cancer",12,9.44881889763779,{"v":8.47969349179372e-05,"d":"8.48E-05"},"IGF1R, HDAC1, CCND2, NTRK1, MMP9, PPARG, MDM2, MPO, NFKB1, BCL2L1, IGFBP3, ATM",114,167,6879,4.33595965962811,0.0174838623841424,{"v":0.000359904817070599,"d":"3.60E-04"},0.106913840659872]
["KEGG pathway","hsa04912","GnRH signaling pathway",9,7.08661417322834,{"v":0.000113132128499288,"d":"1.13E-04"},"EGFR, MAPK1, HRAS, MAP2K1, JUN, MAPK3, MAPK8, GNRHR, MMP2",114,91,6879,5.96790052053209,0.0232580765801628,{"v":0.000470545536940592,"d":"4.71E-04"},0.142616009720686]
["KEGG pathway","hsa04662","B cell receptor signaling pathway",8,6.29921259842519,{"v":1.24772621499192E-4,"d":"1.25E-04"},"AKT1, MAPK1, HRAS, MAP2K1, JUN, GSK3B, MAPK3, NFKB1",114,69,6879,6.99618611746758,0.0256204061325627,{"v":0.000508778851653901,"d":"5.09E-04"},0.157279554148859]
["KEGG pathway","hsa04920","Adipocytokine signaling pathway",8,6.29921259842519,{"v":1.36777681362364E-4,"d":"1.37E-04"},"AKT1, PPARA, TNF, SLC2A1, NFKB1, MAPK8, MTOR, PTPN11",114,70,6879,6.89624060150375,0.028050765286624,{"v":0.000546998486879668,"d":"5.47E-04"},0.172400267237693]
["KEGG pathway","hsa05140","Leishmaniasis",8,6.29921259842519,{"v":0.000149703804273285,"d":"1.50E-04"},"MAPK1, TNF, PTGS2, JUN, MAPK3, NFKB1, NOS2, TGFB1",114,71,6879,6.7991104521868,0.0306608441473389,{"v":5.87388217867745E-4,"d":"5.87E-04"},0.188678728036506]
["KEGG pathway","hsa04520","Adherens junction",8,6.29921259842519,{"v":0.000149703804273285,"d":"1.50E-04"},"CSNK2A2, EGFR, MAPK1, IGF1R, FGFR1, PTPRF, MAPK3, INSR",114,71,6879,6.7991104521868,0.0306608441473389,{"v":5.87388217867745E-4,"d":"5.87E-04"},0.188678728036506]
["KEGG pathway","hsa04650","Natural killer cell mediated cytotoxicity",10,7.87401574803149,{"v":0.000163729415545537,"d":"1.64E-04"},"ICAM1, MAPK1, CASP3, HRAS, TNF, BRAF, MAP2K1, MAPK3, LCK, PTPN11",114,122,6879,4.94607420189818,0.0334850446165593,{"v":0.000630514229333911,"d":"6.31E-04"},0.206339060345883]
["KEGG pathway","hsa05169","Epstein-Barr virus infection",10,7.87401574803149,{"v":0.000163729415545537,"d":"1.64E-04"},"AKT1, ICAM1, HDAC1, JUN, BCL2, MDM2, NFKB1, MAPK8, CCNA2, CDK2",114,122,6879,4.94607420189818,0.0334850446165593,{"v":0.000630514229333911,"d":"6.31E-04"},0.206339060345883]
["KEGG pathway","hsa04932","Non-alcoholic fatty liver disease (NAFLD)",11,8.66141732283464,{"v":0.000172747005111014,"d":"1.73E-04"},"AKT1, PPARA, CASP3, TNF, CASP7, JUN, GSK3B, NFKB1, MAPK8, INSR, TGFB1",114,151,6879,4.39578250261415,0.0352965021205549,{"v":0.000653140809519947,"d":"6.53E-04"},0.217692028307137]
["KEGG pathway","hsa04152","AMPK signaling pathway",10,7.87401574803149,{"v":1.74256644690291E-4,"d":"1.74E-04"},"AKT1, IGF1R, CCND1, HMGCR, PPARG, FASN, CFTR, MTOR, CCNA2, INSR",114,123,6879,4.9058622165169,0.0355994288693332,{"v":0.000647085914939338,"d":"6.47E-04"},0.219592518646682]
["KEGG pathway","hsa05231","Choline metabolism in cancer",9,7.08661417322834,{"v":0.000234814687385636,"d":"2.35E-04"},"AKT1, EGFR, MAPK1, HRAS, MAP2K1, JUN, MAPK3, MAPK8, MTOR",114,101,6879,5.37701928087545,0.0476733565944229,{"v":0.000856601157044778,"d":"8.57E-04"},0.295801764506165]