{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Additional file 3 TableS3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Additional file 3 TableS3","index":0,"n_rows":148,"n_cols":8,"rows_kept":148,"flags":["formulas_cached_only"]}
[]
[null,null,"BIOLOGICAL PROCESS SHARED"]
[null,"GO. ID","Term","Annotateda","Significantb","Expectedc","classicFisherd","FDR_BHe"]
[1,"GO:0015986","ATP synthesis coupled proton transport",17,12,3.06,{"v":2.7e-06,"d":"2.70E-06"},{"v":5.13e-05,"d":"5.13E-05"}]
[2,"GO:0006414","translational elongation",15,10,2.7,{"v":8e-06,"d":"8.00E-06"},{"v":7.6e-05,"d":"7.60E-05"}]
[3,"GO:0001732","formation of cytoplasmic translation initiation complex",12,9,2.16,{"v":2.5e-05,"d":"2.50E-05"},0.0001482]
[4,"GO:0006120","mitochondrial electron transport, NADH t...",6,6,1.08,{"v":3.3e-05,"d":"3.30E-05"},0.0001482]
[5,"GO:0006457","protein folding",43,20,7.74,{"v":3.9e-05,"d":"3.90E-05"},0.0001482]
[6,"GO:0006099","tricarboxylic acid cycle",19,10,3.42,0.00065,0.00205833333333333]
[7,"GO:0007602","phototransduction",6,5,1.08,0.00095,0.00257857142857143]
[8,"GO:0006886","intracellular protein transport",111,38,19.97,0.00132,0.003135]
[9,"GO:0016192","vesicle-mediated transport",123,32,22.13,0.00287,0.00605888888888889]
[10,"GO:0006511","ubiquitin-dependent protein catabolic process",71,22,12.77,0.00373,0.007087]
[11,"GO:0045454","cell redox homeostasis",34,13,6.12,0.00421,0.00727181818181818]
[12,"GO:0006432","phenylalanyl-tRNA aminoacylation",3,3,0.54,0.00581,0.00849153846153846]
[13,"GO:0009408","response to heat",3,3,0.54,0.00581,0.00849153846153846]
[14,"GO:0000398","mRNA splicing, via spliceosome",45,17,8.1,0.00635,0.00856266666666667]
[15,"GO:0006096","glycolytic process",11,6,1.98,0.00676,0.00856266666666667]
[16,"GO:0015991","ATP hydrolysis coupled proton transport",18,8,3.24,0.00847,0.010058125]
[17,"GO:0022900","electron transport chain",15,13,2.7,0.01955,0.0212166666666667]
[18,"GO:0006465","signal peptide processing",4,3,0.72,0.0201,0.0212166666666667]
[19,"GO:0007601","visual perception",7,4,1.26,0.023,0.023]
[]
[null,null,"CELULAR COMPONENT SHARED"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0005737","cytoplasm",797,298,134.1,{"v":1.8e-11,"d":"1.80E-11"},{"v":3.42e-10,"d":"3.42E-10"}]
[2,"GO:0005623","cell",2156,496,362.76,{"v":6.8e-11,"d":"6.80E-11"},{"v":6.46e-10,"d":"6.46E-10"}]
[3,"GO:0005747","mitochondrial respiratory chain complex I",10,10,1.68,{"v":1.7e-08,"d":"1.70E-08"},{"v":1.07666666666667e-07,"d":"1.08E-07"}]
[4,"GO:0016282","eukaryotic 43S preinitiation complex",12,9,2.02,{"v":1.4e-05,"d":"1.40E-05"},{"v":5.32e-05,"d":"5.32E-05"}]
[5,"GO:0033290","eukaryotic 48S preinitiation complex",12,9,2.02,{"v":1.4e-05,"d":"1.40E-05"},{"v":5.32e-05,"d":"5.32E-05"}]
[6,"GO:0015935","small ribosomal subunit",14,10,2.36,{"v":9.6e-05,"d":"9.60E-05"},0.000274444444444444]
[7,"GO:0070469","respiratory chain",20,19,3.37,0.00012,0.000274444444444444]
[8,"GO:0000276","mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)",5,5,0.84,0.00013,0.000274444444444444]
[9,"GO:0019773","proteasome core complex, alpha-subunit complex",7,6,1.18,0.00013,0.000274444444444444]
[10,"GO:0005852","eukaryotic translation initiation factor 3 complex",12,9,2.02,0.00028,0.000532]
[11,"GO:0005739","mitochondrion",177,71,29.78,0.00083,0.00143363636363636]
[12,"GO:0005743","mitochondrial inner membrane",63,36,10.6,0.00223,0.00353083333333333]
[13,"GO:0005681","spliceosomal complex",23,12,3.87,0.00291,0.00425307692307692]
[14,"GO:0030015","CCR4-NOT core complex",3,3,0.5,0.00475,0.00601666666666667]
[15,"GO:0061617","MICOS complex",3,3,0.5,0.00475,0.00601666666666667]
[16,"GO:0045261","proton-transporting ATP synthase complex, catalytic core F(1)",8,5,1.35,0.00894,0.0103047058823529]
[17,"GO:0015934","large ribosomal subunit",10,6,1.68,0.00922,0.0103047058823529]
[18,"GO:0005665","RNA polymerase II, core complex",4,3,0.67,0.0166,0.0166]
[19,"GO:0005787","signal peptidase complex",4,3,0.67,0.0166,0.0166]
[]
[null,null,"MOLECULAR FUNCTION SHARED"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0008137","NADH dehydrogenase (ubiquinone) activity",11,10,1.86,{"v":1.7e-07,"d":"1.70E-07"},{"v":3.23e-06,"d":"3.23E-06"}]
[2,"GO:0004129","cytochrome-c oxidase activity",10,9,1.69,{"v":9.4e-07,"d":"9.40E-07"},{"v":8.93e-06,"d":"8.93E-06"}]
[3,"GO:0003743","translation initiation factor activity",24,14,4.06,{"v":5.3e-06,"d":"5.30E-06"},{"v":3.35666666666667e-05,"d":"3.36E-05"}]
[4,"GO:0051082","unfolded protein binding",29,15,4.91,{"v":1.8e-05,"d":"1.80E-05"},{"v":8.55e-05,"d":"8.55E-05"}]
[5,"GO:0009055","electron transfer activity",37,25,6.26,{"v":0.0001,"d":"1.00E-04"},0.000316666666666667]
[6,"GO:0003746","translation elongation factor activity",9,7,1.52,{"v":0.0001,"d":"1.00E-04"},0.000316666666666667]
[7,"GO:0019843","rRNA binding",11,8,1.86,0.00029,0.000787142857142857]
[8,"GO:0046933","proton-transporting ATP synthase activity, rotational mechanism",11,7,1.86,0.00068,0.001615]
[9,"GO:0004298","threonine-type endopeptidase activity",15,8,2.54,0.00138,0.00291333333333333]
[10,"GO:0015035","protein disulfide oxidoreductase activitY",7,5,1.18,0.00214,0.004066]
[11,"GO:0003924","GTPase activity",97,27,16.42,0.00462,0.00707384615384615]
[12,"GO:0004826","phenylalanine-tRNA ligase activity",3,3,0.51,0.00484,0.00707384615384615]
[13,"GO:0008121","ubiquinol-cytochrome-c reductase activity ",3,3,0.51,0.00484,0.00707384615384615]
[14,"GO:0005524","ATP binding",672,138,113.72,0.00565,0.00766785714285714]
[15,"GO:0015078","proton transmembrane transporter activitY",47,27,7.95,0.00616,0.00780266666666667]
[16,"GO:0051920","peroxiredoxin activity",6,4,1.02,0.00917,0.01064]
[17,"GO:0005544","calcium-dependent phospholipid binding",9,5,1.52,0.00952,0.01064]
[18,"GO:0003723","RNA binding",339,98,57.37,0.01111,0.0117272222222222]
[19,"GO:0005525","GTP binding",139,34,23.52,0.014,0.014]
[]
[null,null,"BIOLOGICAL PROCESS CONTROL"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0006614","SRP-dependent cotranslational protein targeting to membrane",9,4,0.82,0.006,0.025]
[2,"GO:0009058","biosynthetic process",1064,110,97.44,0.0064,0.025]
[3,"GO:0048015","phosphatidylinositol-mediated signaling",5,3,0.46,0.0066,0.025]
[4,"GO:0006672","ceramide metabolic process",2,2,0.18,0.0084,0.025]
[5,"GO:0045116","protein neddylation",2,2,0.18,0.0084,0.025]
[6,"GO:0046854","phosphatidylinositol phosphorylation",10,4,0.92,0.0093,0.025]
[7,"GO:0006351","transcription, DNA-templated",421,45,38.55,0.0097,0.025]
[8,"GO:0045454","cell redox homeostasis",34,8,3.11,0.01,0.025]
[9,"GO:0051013","microtubule severing",3,2,0.27,0.0236,0.0472]
[10,"GO:0000338","protein deneddylation",3,2,0.27,0.0236,0.0472]
[]
[]
[null,null,"CELULAR COMPONENT CONTROL"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0016592","mediator complex",23,9,1.96,{"v":6.1e-05,"d":"6.10E-05"},0.00122]
[2,"GO:0005737","cytoplasm",797,95,68.09,0.00059,0.0059]
[3,"GO:0008180","COP9 signalosome",8,4,0.68,0.00278,0.0185333333333333]
[4,"GO:0005664","nuclear origin of replication recognition complex",2,2,0.17,0.00728,0.02912]
[5,"GO:0005762","mitochondrial large ribosomal subunit",2,2,0.17,0.00728,0.02912]
[6,"GO:0046540","U4/U6 x U5 tri-snRNP complex",6,3,0.51,0.01018,0.0307714285714286]
[7,"GO:0005681","spliceosomal complex",23,6,1.96,0.01077,0.0307714285714286]
[8,"GO:0005688","U6 snRNP",3,2,0.26,0.02061,0.04122]
[9,"GO:0072357","PTW/PP1 phosphatase complex",3,2,0.26,0.02061,0.04122]
[10,"GO:0005786","signal recognition particle, endoplasmic reticulum targeting",3,2,0.26,0.02061,0.04122]
[11,"GO:0005669","transcription factor TFIID complex",8,3,0.68,0.02503,0.0455090909090909]
[12,"GO:0005739","mitochondrion",177,23,15.12,0.02912,0.0485333333333333]
[]
[null,null,"MOLECULAR FUNCTION CONTROL"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0003712","transcription coregulator activity",37,11,3.11,0.00036,0.0072]
[2,"GO:0003899","DNA-directed 5'-3' RNA polymerase activity",27,7,2.27,0.0057,0.0235]
[3,"GO:0019781","NEDD8 activating enzyme activity",2,2,0.17,0.00705,0.0235]
[4,"GO:0008474","palmitoyl-(protein) hydrolase activity",2,2,0.17,0.00705,0.0235]
[5,"GO:0000774","adenyl-nucleotide exchange factor activi...",2,2,0.17,0.00705,0.0235]
[6,"GO:0008568","microtubule-severing ATPase activity",2,2,0.17,0.00705,0.0235]
[7,"GO:0042803","protein homodimerization activity",6,3,0.5,0.00972,0.0243]
[8,"GO:0051087","chaperone binding",6,3,0.5,0.00972,0.0243]
[9,"GO:0003824","catalytic activity",2761,273,231.94,0.01626,0.03306]
[10,"GO:0008270","zinc ion binding",329,39,27.64,0.01653,0.03306]
[11,"GO:0005388","calcium-transporting ATPase activity",3,2,0.25,0.01996,0.0362909090909091]
[]
[null,null,"BIOLOGICAL PROCESS P. berghei"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0006890","retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum",4,4,0.46,0.00017,0.0034]
[2,"GO:0006139","nucleobase-containing compound metabolic process",996,126,114.01,0.00412,0.0412]
[3,"GO:0007264","small GTPase mediated signal transduction",69,10,7.9,0.00886,0.0436]
[4,"GO:0019441","tryptophan catabolic process to kynurenine",2,2,0.23,0.01308,0.0436]
[5,"GO:0006471","protein ADP-ribosylation",2,2,0.23,0.01308,0.0436]
[6,"GO:0006044","N-acetylglucosamine metabolic process",2,2,0.23,0.01308,0.0436]
[]
[null,null,"CELULAR COMPONENT P. berghei"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0032039","integrator complex",7,4,0.76,0.0037,0.044]
[2,"GO:0005730","nucleolus",35,10,3.8,0.0044,0.044]
[]
[null,null,"MOLECULAR FUNCTION P. berghei"]
[null,"GO. ID","Term","Annotated","Significant","Expected","classicFisher","FDR_BH"]
[1,"GO:0005524","ATP binding",672,104,77.35,0.00064,0.0068]
[2,"GO:0005515","protein binding",1733,247,199.48,0.00068,0.0068]
[3,"GO:0008270","zinc ion binding",329,56,37.87,0.00146,0.00855]
[4,"GO:0046872","metal ion binding",1095,161,126.04,0.00171,0.00855]
[5,"GO:0035064","methylated histone binding",4,3,0.46,0.00556,0.02224]
[6,"GO:0051287","NAD binding",25,8,2.88,0.00706,0.0235333333333333]
[7,"GO:0004386","helicase activity",56,15,6.45,0.00987,0.0282]
[8,"GO:0008234","cysteine-type peptidase activity",63,8,7.25,0.01665,0.0383777777777778]
[9,"GO:0030170","pyridoxal phosphate binding",30,8,3.45,0.01727,0.0383777777777778]
[10,"GO:0004435","phosphatidylinositol phospholipase C act...",3,2,0.35,0.03666,0.0465625]
[11,"GO:0043141","ATP-dependent 5'-3' DNA helicase activit...",3,2,0.35,0.03666,0.0465625]
[12,"GO:0008376","acetylgalactosaminyltransferase activity",3,2,0.35,0.03666,0.0465625]
[13,"GO:0004449","isocitrate dehydrogenase (NAD+) activity",3,2,0.35,0.03666,0.0465625]
[14,"GO:0051536","iron-sulfur cluster binding",40,9,4.6,0.03696,0.0465625]
[15,"GO:0003678","DNA helicase activity",17,6,1.96,0.03701,0.0465625]
[16,"GO:0036402","proteasome-activating ATPase activity",7,3,0.81,0.03725,0.0465625]
[]
[null,"a Number of transcripts annotated with GO annotation"]
[null,"b Number of transcripts statistically significant (Fisher test and p-value adjusted by Benjamin Horberg (BH))"]
[null,"c Number of transcripts expected after Fisher test"]
[null,"d p-value of Fisher test"]
[null,"e p-value of Fisher test adjusted by BH"]