{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Table (2)"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table (2)","index":0,"n_rows":35,"n_cols":13,"rows_kept":35,"merged":[[0,1,0,3],[0,4,0,6],[0,7,0,9],[0,10,0,12],[19,1,19,3],[19,4,19,6],[19,7,19,9],[19,10,19,12]],"flags":["formulas_cached_only"]}
["Adverse Effect","Baseline (Month 0)",null,null,"Pre-RT (Month 3) ",null,null,"During RT (Month 5)",null,null,"Post-RT Follow up (Month 12)"]
[null,"Placebo (n=44)","Metformin (n=37)","p","Placebo (n=38)","Metformin (n=32)","p","Placebo (n=36)","Metformin (n=32)","p","Placebo (n=28)","Metformin (n=29)","p"]
["Gastrointestinal"]
["Bloating"]
["    Grade 0 or 1","44 (100)","37 (100)","-","37 (97)","32 (100)","-","36 (100)","32 (100)","-","28 (100)","29 (100)","-"]
["    Grade 2, 3 or 4",0,0,"-","1 (2.6)",0,0.355,0,0,"-",0,0,"-"]
["Dyspepsia"]
["    Grade 0 or 1","43 (97)","35 (95)","-","36 (95)","31 (97)","-","36 (100)","31 (97)","-","28 (100)","28 (97)","-"]
["    Grade 2, 3 or 4","1 (2.3)","2 (5.4)",0.563,"2 (5.3)","1 (3.1)",0.66,0,"1 (3.1)",0.285,0,"1 (3.5)",0.322]
["Nausea"]
["    Grade 0 or 1","44 (100)","37 (100)","-","38 (100)","32 (100)","-","36 (100)","32 (100)","-","28 (100)","29 (100)","-"]
["    Grade 2, 3 or 4",0,0,"-",0,0,"-",0,0,"-",0,0,"-"]
["Diarrhea"]
["    Grade 0 or 1","44 (100)","37 (100)","-","38 (100)","32 (100)","-","35 (97)","32 (100)","-","28 (100)","29 (100)","-"]
["    Grade 2, 3 or 4",0,0,"-",0,0,"-","1 (2.8)",0,0.342,0,0,"-"]
["Flatulence"]
["    Grade 0 or 1","44 (100)","37 (100)","-","37 (97)","32 (100)","-","36 (100)","32 (100)","-","28 (100)","29 (100)","-"]
["    Grade 2, 3 or 4",0,0,"-","1 (2.6)",0,0.355,0,0,"-",0,0,"-"]
["Overall GI toxicity","1 (2.3)","2 (5.4)",0.408,"3 (7.9)","1 (3.1)",0.392,"1 (2.8)","1 (3.1)",0.636,0,"1 (3.5)",0.322]
[null,"Baseline (Month 0)",null,null,"Pre-RT (Month 3) ",null,null,"During RT (Month 5)",null,null,"Post-RT Follow up (Month 12)"]
[null,"Placebo (n=44)","Metformin (n=37)","p","Placebo (n=38)","Metformin (n=32)","p","Placebo (n=36)","Metformin (n=32)","p","Placebo (n=28)","Metformin (n=29)","p"]
["Genitourinary"]
["Frequency"]
["    Grade 0 or 1","43 (97)","36 (97)","-","37 ( 97)","29 (91)","-","30 (83)","31 (97)","-","27 (96)","29 (100)","-"]
["    Grade 2, 3 or 4","1 (2.3)","1 (2.7)",0.901,"1 (2.6)","3 (9.4)",0.226,"6 (17)",0,0.033,"1 (3.6)",0,0.305]
["Urgency"]
["    Grade 0 or 1","41 (93)",0,"-","35 (92)","32 (100)","-","32 (89)","32 (100)","-","27 (96)","29 (100)","-"]
["    Grade 2, 3 or 4","3 (6.8)",0,0.154,"3 (7.9)",0,0.104,"4 (11)",0,0.052,"1 (3.6)",0,0.305]
["Urinary Retention"]
["    Grade 0 or 1","43 (97)","37 (100)","-","37 (97)","32 (100)","-","35 (97)","31 (97)","-","27 (96)","29 (100)","-"]
["    Grade 2, 3 or 4","1 (2.3)",0,0.356,"1 (2.6)",0,0.355,"1 (2.8)","1 (3.1)",0.982,"1 (3.6)",0,0.305]
["Cystitis"]
["     Grade 0 or 1","43 (97)","37 (100)","-","37 (97)","32 (100)","-","33 (92)","32 (100)","-","28 (100)","29 (100)","-"]
["     Grade 2, 3 or 4","1 (2.3)",0,0.356,"1 (2.6)",0,0.355,"3 (8.3)",0,0.095,0,0,"-"]
["Overall GU toxicity","3 (6.8)","2 (5.4)",0.792,"4 (11)","4 (13)",0.796,"7 (19)","3 (9.4)",0.303,"1 (3.6)","2 (6.9)",0.574]