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["Suplpemental Table 2. Pathway Analysis of Differentially Expressed (DE) Genes and their effect on Networks with impact on their Predicted Activation State."]
[]
["Comparison","Categories","Diseases or Functions Annotation","p-value","Predicted Activation State","Activation z-score","Molecules","# Molecules"]
["A1 versus A2","Cellular Function and Maintenance","Cellular homeostasis",{"v":7.58e-06,"d":"7.58E-06"},"Decreased",-3.307,"ALOX5,ARG1,ATP13A4,ATP2B2,C3,CCL19,CCL22,CD2,CD3D,CD3G,CD4,CD5,CD52,CD69,CD74,CYBB,EGF,IL2RG,IRF8,LCP2,SAA1,SASH3,SCARA5,SLC46A2,UBD",25]
[null,"Cellular Movement,Immune Cell Trafficking","Leukocyte migration",{"v":7.3E-9,"d":"7.30E-09"},"Decreased",-3.231,"ALOX5,ALOX5AP,ARG1,C3,CCL19,CCL22,CD2,CD4,CD5,CD69,CD74,CD84,CYBB,EGF,EVL,KLK5,LCP2,LYZ,MMP9,SAA1,SERPINB3,TNFRSF21,VCAM1",23]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Lymphocyte migration",{"v":7.2e-11,"d":"7.20E-11"},"Decreased",-3.171,"ALOX5,C3,CCL19,CCL22,CD2,CD4,CD69,CD74,EVL,KLK5,LCP2,MMP9,SAA1,SERPINB3,TNFRSF21,VCAM1",16]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Cell movement of neutrophils",{"v":8.18e-06,"d":"8.18E-06"},"Decreased",-3.109,"ALOX5,ALOX5AP,C3,CCL19,CD69,CD74,CYBB,MMP9,SAA1,VCAM1",10]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Cell movement of leukocytes",{"v":6.61e-09,"d":"6.61E-09"},"Decreased",-3.076,"ALOX5,ALOX5AP,ARG1,C3,CCL19,CCL22,CD2,CD4,CD5,CD69,CD74,CYBB,EGF,EVL,KLK5,LCP2,MMP9,SAA1,SERPINB3,TNFRSF21,VCAM1",21]
[null,"Cellular Movement","Migration of cells",{"v":4.79e-07,"d":"4.79E-07"},"Decreased",-3.068,"ALOX5,ALOX5AP,ARG1,C3,CCL19,CCL22,CD2,CD4,CD5,CD69,CD74,CD84,CYBB,EBF3,EGF,EVL,HOTAIRM1,HOXA1,KLK5,KRT2,LCP2,LYZ,MMP9,NOSTRIN,PAX3,PCSK5,SAA1,SERPINB3,SLC1A3,SRGN,TNFRSF21,VCAM1",32]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Activation of leukocytes",{"v":1.77e-10,"d":"1.77E-10"},"Decreased",-3.037,"ALOX5,C3,CCL22,CD2,CD3G,CD4,CD5,CD69,CD74,CD84,CYBB,HLA-DPB1,IL2RG,IRF8,LCP2,MMP9,NLRC3,SAA1,SASH3,TNFRSF21,VCAM1",21]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Activation of lymphocytes",{"v":2.67e-09,"d":"2.67E-09"},"Decreased",-2.924,"ALOX5,C3,CCL22,CD2,CD3G,CD4,CD5,CD69,CD74,HLA-DPB1,IL2RG,IRF8,NLRC3,SAA1,SASH3,TNFRSF21",16]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Cell movement of granulocytes",{"v":1.18e-06,"d":"1.18E-06"},"Decreased",-2.854,"ALOX5,ALOX5AP,C3,CCL19,CD2,CD69,CD74,CYBB,KLK5,MMP9,SAA1,VCAM1",12]
[null,"Cellular Development,Cellular Growth and Proliferation,Hematological System Development and Function,Hematopoiesis,Lymphoid Tissue Structure and Development,Tissue Development","Leukopoiesis",{"v":3.83e-06,"d":"3.83E-06"},"Decreased",-2.85,"ALOX5,ARG1,CCL19,CD2,CD3D,CD3G,CD4,CD5,CD69,CD74,CYBB,IL2RG,IRF8,LCP2,SASH3,SLC46A2,UBD",17]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Activation of T lymphocytes",{"v":2.96E-7,"d":"2.96E-07"},"Decreased",-2.791,"C3,CCL22,CD2,CD3G,CD4,CD74,HLA-DPB1,IL2RG,IRF8,NLRC3,SAA1,TNFRSF21",12]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Interaction of lymphocytes",{"v":2.14e-07,"d":"2.14E-07"},"Decreased",-2.758,"CCL19,CCL22,CD2,CD4,CD69,EVL,LCP2,SAA1,VCAM1",9]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Interaction of leukocytes",{"v":9.18e-07,"d":"9.18E-07"},"Decreased",-2.694,"C3,CCL19,CCL22,CD2,CD4,CD69,CD74,CYBB,EVL,LCP2,SAA1,VCAM1",12]
[null,"Cell-To-Cell Signaling and Interaction","Activation of cells",{"v":9.55e-09,"d":"9.55E-09"},"Decreased",-2.623,"ALOX5,C3,CCL22,CD2,CD3G,CD4,CD5,CD69,CD74,CD84,CYBB,EGF,HLA-DPB1,IL2RG,IRF8,KRT2,LCP2,MMP9,NLRC3,SAA1,SASH3,TNFRSF21,VCAM1",23]
[null,"Cell-To-Cell Signaling and Interaction","Binding of blood cells",{"v":5.51e-08,"d":"5.51E-08"},"Decreased",-2.618,"C3,CCL19,CCL22,CD2,CD4,CD69,CD74,CD84,CYBB,EVL,IRF8,LCP2,SAA1,VCAM1",14]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Recruitment of leukocytes",{"v":1.04E-6,"d":"1.04E-06"},"Decreased",-2.612,"ALOX5,ALOX5AP,C3,CCL19,CCL22,CD4,CD69,CD74,LYZ,MMP9,VCAM1",11]
[null,"Lymphoid Tissue Structure and Development,Tissue Morphology","Quantity of lymphoid tissue",{"v":6.97e-07,"d":"6.97E-07"},"Decreased",-2.602,"ARG1,C3,CD3G,CD4,CD5,CD74,CD84,HOXA3,IL2RG,IRF8,LCP2,SASH3",12]
[null,"Hematological System Development and Function,Tissue Morphology","Quantity of leukocytes",{"v":8.79e-11,"d":"8.79E-11"},"Decreased",-2.576,"ADAMTS12,ALOX5,ARG1,C3,CCL19,CCL22,CD3D,CD3G,CD4,CD5,CD69,CD74,CD84,CYBB,HOXA3,IL2RG,IRF8,LCP2,MMP9,NLRC3,SAA1,SASH3,TNFRSF21,VCAM1,ZC3H12D",25]
[null,"Cellular Development,Cellular Growth and Proliferation,Embryonic Development,Hematological System Development and Function,Hematopoiesis,Lymphoid Tissue Structure and Development,Organ Development,Organismal Development,Tissue Development","Lymphopoiesis",{"v":2.24e-05,"d":"2.24E-05"},"Decreased",-2.554,"ARG1,CCL19,CD2,CD3D,CD3G,CD4,CD5,CD69,CD74,IL2RG,IRF8,LCP2,SASH3,SLC46A2",14]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Binding of leukocytes",{"v":5.59e-06,"d":"5.59E-06"},"Decreased",-2.542,"C3,CCL19,CCL22,CD2,CD4,CD69,CD74,CYBB,EVL,LCP2,VCAM1",11]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Movement","Recruitment of myeloid cells",{"v":1.54E-7,"d":"1.54E-07"},"Decreased",-2.534,"ALOX5,ALOX5AP,C3,CCL19,CCL22,CD4,CD69,CD74,LYZ,MMP9,VCAM1",11]
[null,"Cell-mediated Immune Response,Cellular Function and Maintenance,Hematological System Development and Function","T cell homeostasis",{"v":1.8e-06,"d":"1.80E-06"},"Decreased",-2.524,"ARG1,CCL19,CD2,CD3D,CD3G,CD4,CD5,CD69,CD74,IL2RG,IRF8,LCP2,SASH3,SLC46A2",14]
[null,"Cell-mediated Immune Response,Cellular Development,Cellular Function and Maintenance,Cellular Growth and Proliferation,Embryonic Development,Hematological System Development and Function,Hematopoiesis,Lymphoid Tissue Structure and Development,Organ Development,Organismal Development,Tissue Development","T cell development",{"v":7.53e-06,"d":"7.53E-06"},"Decreased",-2.524,"ARG1,CD2,CD3D,CD3G,CD4,CD5,CD69,CD74,IL2RG,IRF8,LCP2,SASH3,SLC46A2",13]
[null,"Inflammatory Response","Inflammatory response",{"v":9.66e-07,"d":"9.66E-07"},"Decreased",-2.521,"ADAMTS12,ALOX5,ALOX5AP,C3,CCL19,CCL22,CD4,CD69,CD74,CD84,CYBB,EGF,LYZ,MMP9,NLRC3,SAA1,SASH3,VCAM1",18]
[null,"Cellular Movement","Cell movement",{"v":1.87e-06,"d":"1.87E-06"},"Decreased",-2.456,"ALOX5,ALOX5AP,ARG1,C3,CCL19,CCL22,CD2,CD4,CD5,CD69,CD74,CD84,CYBB,EBF3,EGF,EVL,HOTAIRM1,HOXA1,IRF8,KLK5,KRT2,LCP2,LYZ,MMP9,NOSTRIN,PAX3,PCSK5,SAA1,SERPINB3,SLC1A3,SRGN,TNFRSF21,VCAM1",33]
[null,"Cell-To-Cell Signaling and Interaction,Inflammatory Response","Immune response of phagocytes",{"v":0.000775,"d":"7.75E-04"},"Decreased",-2.447,"C3,CCL19,CCL22,IRF8,SAA1,VCAM1",6]
[null,"Cell-mediated Immune Response,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","T cell migration",{"v":1.54e-08,"d":"1.54E-08"},"Decreased",-2.442,"ALOX5,C3,CCL19,CCL22,CD4,CD69,CD74,KLK5,LCP2,MMP9,SAA1,TNFRSF21",12]
[null,"Gastrointestinal Disease,Hepatic System Disease,Organismal Injury and Abnormalities","Liver Damage",{"v":4.35E-4,"d":"4.35E-04"},"Decreased",-2.433,"ALOX5,C3,EGF,IL2RG,MMP9,SAA1",6]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Recruitment of granulocytes",{"v":1.08E-6,"d":"1.08E-06"},"Decreased",-2.425,"ALOX5,ALOX5AP,C3,CCL19,CCL22,CD69,LYZ,MMP9,VCAM1",9]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Migration of granulocytes",{"v":8.75e-05,"d":"8.75E-05"},"Decreased",-2.4,"C3,CCL19,CYBB,MMP9,SAA1,VCAM1",6]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Interaction of T lymphocytes",{"v":4.69e-07,"d":"4.69E-07"},"Decreased",-2.391,"CCL19,CCL22,CD2,CD4,CD69,EVL,LCP2,VCAM1",8]
[null,"Hematological System Development and Function,Lymphoid Tissue Structure and Development,Tissue Morphology","Quantity of T lymphocytes",{"v":1.18e-09,"d":"1.18E-09"},"Decreased",-2.389,"CCL19,CD3D,CD3G,CD4,CD5,CD69,CD74,CD84,HOXA3,IL2RG,IRF8,LCP2,MMP9,SAA1,SASH3,TNFRSF21,VCAM1,ZC3H12D",18]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function,Immune Cell Trafficking","Adhesion of immune cells",{"v":1.61e-05,"d":"1.61E-05"},"Decreased",-2.381,"C3,CCL19,CCL22,CD2,CD4,CD69,CD74,CYBB,LCP2,VCAM1",10]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Binding of mononuclear leukocytes",{"v":5.44e-06,"d":"5.44E-06"},"Decreased",-2.376,"CCL19,CCL22,CD2,CD4,CD69,EVL,LCP2,VCAM1",8]
[null,"Cellular Movement","Chemotaxis of myeloid cells",{"v":3.05E-6,"d":"3.05E-06"},"Decreased",-2.375,"ALOX5,C3,CCL19,CCL22,CD4,CD69,CD74,CYBB,SAA1,VCAM1",10]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Chemotaxis of leukocytes",{"v":3.97e-06,"d":"3.97E-06"},"Decreased",-2.36,"ALOX5,C3,CCL19,CCL22,CD4,CD69,CD74,CYBB,MMP9,SAA1,VCAM1",11]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Cell movement of phagocytes",{"v":3.43e-08,"d":"3.43E-08"},"Decreased",-2.356,"ALOX5,ALOX5AP,ARG1,C3,CCL19,CCL22,CD4,CD5,CD69,CD74,CYBB,EGF,KLK5,MMP9,SAA1,TNFRSF21,VCAM1",17]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Recruitment of phagocytes",{"v":6.51e-07,"d":"6.51E-07"},"Decreased",-2.356,"ALOX5,ALOX5AP,CCL19,CCL22,CD4,CD69,CD74,LYZ,MMP9,VCAM1",10]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Chemotaxis of phagocytes",{"v":4.21e-06,"d":"4.21E-06"},"Decreased",-2.343,"ALOX5,C3,CCL19,CCL22,CD4,CD69,CD74,CYBB,SAA1,VCAM1",10]
[null,"Cellular Movement","Cell movement of myeloid cells",{"v":2.68e-08,"d":"2.68E-08"},"Decreased",-2.325,"ALOX5,ALOX5AP,ARG1,C3,CCL19,CCL22,CD2,CD4,CD69,CD74,CYBB,EGF,KLK5,MMP9,SAA1,TNFRSF21,VCAM1",17]
[null,"Hematological System Development and Function,Lymphoid Tissue Structure and Development,Tissue Morphology","Quantity of lymphocytes",{"v":2.91e-08,"d":"2.91E-08"},"Decreased",-2.316,"C3,CCL19,CD3D,CD3G,CD4,CD5,CD69,CD74,CD84,HOXA3,IL2RG,IRF8,LCP2,MMP9,SAA1,SASH3,TNFRSF21,VCAM1,ZC3H12D",19]
[null,"Hematological System Development and Function,Lymphoid Tissue Structure and Development,Tissue Morphology","Quantity of CD4+ T-lymphocytes",{"v":3.18e-07,"d":"3.18E-07"},"Decreased",-2.274,"CD3D,CD4,CD5,CD69,CD74,CD84,IL2RG,LCP2,TNFRSF21",9]
[null,"Cell-To-Cell Signaling and Interaction","Adhesion of blood cells",{"v":4.68e-06,"d":"4.68E-06"},"Decreased",-2.258,"C3,CCL19,CCL22,CD2,CD4,CD69,CD74,CYBB,LCP2,SAA1,VCAM1",11]
[null,"Inflammatory Response","Immune response of cells",{"v":0.00077,"d":"7.70E-04"},"Decreased",-2.245,"C3,CCL19,CCL22,CD4,CD69,CD74,IL2RG,IRF8,LCP2,SAA1,VCAM1",11]
[null,"Cell-mediated Immune Response,Cellular Development,Cellular Function and Maintenance,Cellular Growth and Proliferation,Embryonic Development,Hematological System Development and Function,Hematopoiesis,Lymphoid Tissue Structure and Development,Organ Development,Organismal Development,Tissue Development","Differentiation of T lymphocytes",{"v":4.58e-05,"d":"4.58E-05"},"Decreased",-2.228,"CD3D,CD3G,CD4,CD69,CD74,IL2RG,IRF8,LCP2,SASH3,SLC46A2",10]
[null,"Cell-To-Cell Signaling and Interaction","Adhesion of tumor cell lines",{"v":0.000266,"d":"2.66E-04"},"Decreased",-2.225,"CYBB,EGF,KLK5,LCP2,NOSTRIN,SAA1,SRGN,VCAM1",8]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Growth and Proliferation,Hematological System Development and Function","Stimulation of T lymphocytes",{"v":9.21e-08,"d":"9.21E-08"},"Decreased",-2.213,"C3,CCL19,CD2,CD4,CD5,CD52,CD69,CD74",8]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Recruitment of neutrophils",{"v":3.27e-05,"d":"3.27E-05"},"Decreased",-2.213,"ALOX5,ALOX5AP,CCL19,CCL22,CD69,LYZ,MMP9",7]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Chemotaxis of neutrophils",{"v":1.14E-3,"d":"1.14E-03"},"Decreased",-2.213,"ALOX5,C3,CCL19,CD69,CD74",5]
[null,"Cellular Movement","Cell movement of leukemia cell lines",{"v":9e-05,"d":"9.00E-05"},"Decreased",-2.201,"C3,CCL19,CCL22,LCP2,MMP9,VCAM1",6]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Migration of neutrophils",{"v":0.000265,"d":"2.65E-04"},"Decreased",-2.183,"CCL19,CYBB,MMP9,SAA1,VCAM1",5]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Binding of T lymphocytes",{"v":3.1E-6,"d":"3.10E-06"},"Decreased",-2.177,"CCL19,CCL22,CD2,CD69,EVL,LCP2,VCAM1",7]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Cellular infiltration by leukocytes",{"v":3.81e-06,"d":"3.81E-06"},"Decreased",-2.173,"ALOX5AP,ARG1,C3,CCL19,CCL22,CD2,CYBB,KLK5,MMP9,SAA1,TNFRSF21,VCAM1",12]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking,Inflammatory Response","Cell movement of dendritic cells",{"v":1.46e-05,"d":"1.46E-05"},"Decreased",-2.139,"C3,CCL19,CCL22,CD5,CD74,CYBB,MMP9",7]
[null,"Cell-To-Cell Signaling and Interaction,Inflammatory Response","Immune response of antigen presenting cells",{"v":0.000471,"d":"4.71E-04"},"Decreased",-2.137,"C3,CCL19,CCL22,CD74,IRF8,SAA1",6]
[null,"Cell-mediated Immune Response,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Cell movement of T lymphocytes",{"v":5.1e-07,"d":"5.10E-07"},"Decreased",-2.067,"C3,CCL19,CCL22,CD69,CD74,KLK5,LCP2,MMP9,SAA1,TNFRSF21",10]
[null,"Cell-To-Cell Signaling and Interaction,Hematological System Development and Function","Activation of myeloid cells",{"v":8.16e-05,"d":"8.16E-05"},"Decreased",-2.065,"C3,CCL22,CD4,CD84,CYBB,LCP2,MMP9,SAA1,VCAM1",9]
[null,"Cellular Function and Maintenance,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Localization of leukocytes",{"v":4.85e-06,"d":"4.85E-06"},"Decreased",-2,"C3,CCL19,CD4,CD69",4]
[null,"Cell-To-Cell Signaling and Interaction,Cellular Compromise,Cellular Function and Maintenance,Inflammatory Response","Respiratory burst of phagocytes",{"v":3.01E-5,"d":"3.01E-05"},"Decreased",-2,"C3,CCL22,IRF8,VCAM1",4]
[null,"Cell-To-Cell Signaling and Interaction,Inflammatory Response","Respiratory burst of myeloid cells",{"v":4.5e-05,"d":"4.50E-05"},"Decreased",-2,"C3,CCL22,IRF8,VCAM1",4]
[null,"Lymphoid Tissue Structure and Development,Tissue Morphology","Quantity of lymph follicle",{"v":1.13E-4,"d":"1.13E-04"},"Decreased",-2,"C3,CD74,CD84,IL2RG,IRF8,SASH3",6]
[null,"Hematological System Development and Function,Hematopoiesis,Lymphoid Tissue Structure and Development,Organ Morphology,Tissue Morphology","Quantity of double-positive thymocyte",{"v":0.000131,"d":"1.31E-04"},"Decreased",-2,"CD4,CD5,IL2RG,LCP2,SASH3",5]
[null,"Developmental Disorder,Organismal Injury and Abnormalities","Hypoplasia of lymphatic system",{"v":0.000725,"d":"7.25E-04"},"Increased",2.166,"CD3G,HOXA3,IL2RG,LCP2,SASH3",5]
[null,"Infectious Diseases","Infection of mammalia",{"v":0.000258,"d":"2.58E-04"},"Increased",2.301,"C3,CD4,CD74,CYBB,IL2RG,IRF8,MMP9,UBD",8]
["A1 versus A3","Cellular Movement","Cell movement",{"v":8.08e-11,"d":"8.08E-11"},"Decreased",-3.253,"A2M,ACAP3,ACKR3,ACP5,ADAM33,ADD2,ADRB2,ADTRP,ALOX5,ANPEP,APOE,AQP1,ARG1,BMP2,C3,CBLB,CCL2,CCN1,CCN3,CD300A,CD74,CD93,CEACAM6,CHI3L1,CHST1,CLCA2,CLDN7,CLEC10A,CNN1,COL7A1,CST6,CTNND2,CTSV,CXCR2,CYBB,CYP1B1,DGKA,DIO2,DLL4,DNAH11,DOCK8,DPP10-AS1,EBF3,EEF1A2,EGFL7,EGR1,EGR3,ELMO1,EPHB2,ERG,ESAM,EVL,F10,FGF7,FGFBP1,FLT4,FOXQ1,GJA1,GMFG,GPR132,H19,HBEGF,HMGCR,HOTAIRM1,ITGA11,ITGA8,ITGA9,ITGAL,ITPR1,KDR,KIF26B,KLF8,KLK5,KRT2,LAMA3,LAMA5,LIF,LIMS2,LINC00672,LOXL2,LRRC6,LSP1,MAPK15,MFNG,MIA,MINK1,MMP19,MMP28,MYO1F,NAV1,NCF2,NCF4,NEK3,NKD2,NR5A2,OVOL2,P2RX7,P2RY2,PALLD,PARVG,PDE2A,PDE4DIP,PDGFRA,PDGFRB,PLEKHG5,PMP22,POSTN,PRKN,PTH1R,PTPRB,PTPRU,RASGRP2,RGS5,RHOG,RUNX1,RUNX2,RUNX3,SELE,SEMA3C,SEMA3E,SERPINB3,SERPINE2,SGK1,SKAP2,SLC1A3,SLC7A5,SLC7A8,SLC9A3R2,SNCA,SOD3,SPARCL1,STAB1,TACR1,TBX3,THBS2,TNFRSF21,TNFRSF25,TPM2,TRPC6,TSPAN15,TSPAN32,VASH1,VWF",143]
[null,"Molecular Transport","Quantity of metal ion",{"v":2.71e-06,"d":"2.71E-06"},"Decreased",-2.999,"A2M,APOE,AQP1,C3,CALN1,CCL2,CLDN7,CXCR2,CYBB,ESRRG,FGF7,GRIN2A,GRK5,HOXA3,HSD11B2,IRAG1,ITPR1,ITPR2,KDR,NPPC,NRN1,P2RX7,P2RY2,PMP22,PTH1R,RHCG,SCNN1B,SELE,SGK1,SLC9A3R2,TACR1,TRPC6,WNK4",33]
[null,"Cellular Movement","Chemotaxis",{"v":1.71e-05,"d":"1.71E-05"},"Decreased",-2.901,"A2M,ACKR3,ALOX5,APOE,BMP2,C3,CCL2,CCN1,CCN3,CD74,CXCR2,CYBB,DGKA,EGR3,ELMO1,EPHB2,F10,FGF7,FGFBP1,GPR132,HBEGF,ITGA9,ITGAL,KDR,LIF,LSP1,MMP28,MYO1F,P2RY2,PDGFRA,PDGFRB,PLEKHG5,RGS5,RHOG,SELE,SEMA3E,THBS2,TRPC6",38]
[null,"Cellular Movement,Immune Cell Trafficking","Migration of lymphatic system cells",{"v":1.06E-5,"d":"1.06E-05"},"Decreased",-2.874,"ACKR3,ADRB2,ALOX5,APOE,C3,CBLB,CCL2,CD74,CTSV,CXCR2,DOCK8,ELMO1,EVL,FLT4,GPR132,ITGA9,ITGAL,KDR,KLK5,P2RX7,PTPRB,RUNX1,SELE,SEMA3E,SERPINB3,SERPINE2,STAB1,THBS2,TNFRSF21",29]
[null,"Molecular Transport","Quantity of metal",{"v":8.58e-06,"d":"8.58E-06"},"Decreased",-2.828,"A2M,ADD2,APOE,AQP1,BMP2,C3,CALN1,CCL2,CLDN7,CXCR2,CYBB,ESRRG,FGF7,GRIN2A,GRK5,HOXA3,HSD11B2,IRAG1,ITPR1,ITPR2,KDR,NPPC,NRN1,P2RX7,P2RY2,PMP22,PTH1R,RHCG,SCNN1B,SELE,SGK1,SLC9A3R2,TACR1,TRPC6,WNK4",35]
[null,"Cellular Function and Maintenance,Molecular Transport","Flux of ion",{"v":9.12e-06,"d":"9.12E-06"},"Decreased",-2.816,"A2M,ADRB2,APOE,BCAP31,C3,CCL2,CD300A,CXCR2,CYBB,EGR1,EPHB2,ERG,GJA1,GPR132,NPPC,P2RX7,P2RY2,RHCG,RIC3,SCNN1B,SGK1,SLC12A4,SNCA,TRPC6,VWF,WNK4",26]
[null,"Cardiovascular System Development and Function,Tissue Morphology","Permeability of blood vessel",{"v":9.94e-05,"d":"9.94E-05"},"Decreased",-2.733,"APOE,AQP1,C3,CXCR2,ESAM,KDR,LSP1,PTPRB,TACR1,TRPC6,VWF",11]
[null,"Cell Signaling,Cellular Function and Maintenance,Molecular Transport,Vitamin and Mineral Metabolism","Flux of Ca2+",{"v":9.07e-05,"d":"9.07E-05"},"Decreased",-2.684,"A2M,ADRB2,APOE,C3,CCL2,CD300A,CXCR2,CYBB,EGR1,EPHB2,ERG,GJA1,GPR132,NPPC,P2RX7,P2RY2,RIC3,SGK1,SNCA,TRPC6,VWF,WNK4",22]
[null,"Cellular Movement","Migration of cells",{"v":7.22e-11,"d":"7.22E-11"},"Decreased",-2.682,"A2M,ACAP3,ACKR3,ACP5,ADAM33,ADD2,ADRB2,ADTRP,ALOX5,ANPEP,APOE,AQP1,ARG1,BMP2,C3,CBLB,CCL2,CCN1,CCN3,CD300A,CD74,CD93,CEACAM6,CHI3L1,CHST1,CLCA2,CLDN7,CLEC10A,COL7A1,CST6,CTSV,CXCR2,CYBB,CYP1B1,DIO2,DLL4,DOCK8,DPP10-AS1,EBF3,EEF1A2,EGFL7,EGR1,EGR3,ELMO1,EPHB2,ERG,ESAM,EVL,F10,FGF7,FLT4,FOXQ1,GJA1,GMFG,GPR132,H19,HBEGF,HMGCR,HOTAIRM1,ITGA8,ITGA9,ITGAL,ITPR1,KDR,KIF26B,KLK5,KRT2,LAMA3,LAMA5,LIF,LIMS2,LINC00672,LOXL2,LSP1,MAPK15,MFNG,MIA,MINK1,MMP19,MMP28,MYO1F,NAV1,NCF2,NCF4,NEK3,NKD2,NR5A2,OVOL2,P2RX7,P2RY2,PALLD,PDE2A,PDE4DIP,PDGFRA,PDGFRB,PLEKHG5,PMP22,POSTN,PRKN,PTH1R,PTPRB,PTPRU,RASGRP2,RGS5,RHOG,RUNX1,RUNX2,RUNX3,SELE,SEMA3C,SEMA3E,SERPINB3,SERPINE2,SGK1,SKAP2,SLC1A3,SLC7A5,SLC7A8,SLC9A3R2,SOD3,SPARCL1,STAB1,TACR1,TBX3,THBS2,TNFRSF21,TNFRSF25,TPM2,TRPC6,TSPAN15,VASH1,VWF",132]
[null,"Cell-To-Cell Signaling and Interaction","Adhesion of tumor cell lines",{"v":6.64E-6,"d":"6.64E-06"},"Decreased",-2.682,"APOE,CCL2,CCN1,CCN3,CLCA2,CST6,CYBB,EGFL7,EGR1,EGR3,F10,GMFG,ITGA9,ITGAL,KLK5,LAMA3,LGALS4,LIF,MINK1,MMP19,P2RY2,PARVG,RASGRP2,SELE,SLC7A5,TNFRSF25",26]
[null,"Cellular Function and Maintenance,Molecular Transport","Flux of cation",{"v":3.24e-05,"d":"3.24E-05"},"Decreased",-2.662,"A2M,ADRB2,APOE,C3,CCL2,CD300A,CXCR2,CYBB,EGR1,EPHB2,ERG,GJA1,GPR132,NPPC,P2RX7,P2RY2,RHCG,RIC3,SCNN1B,SGK1,SNCA,TRPC6,VWF,WNK4",24]
[null,"Cellular Function and Maintenance","Ion homeostasis of cells",{"v":0.000308,"d":"3.08E-04"},"Decreased",-2.659,"A2M,ADRB2,APOE,BCAP31,C3,CCL2,CD300A,CLDN7,CXCR2,CYBB,EGR1,EPHB2,ERG,FAM20A,GJA1,GPR132,GRIK2,HSD11B2,ITPR1,KDR,NPPC,P2RX7,P2RY2,PDGFRA,PTH1R,RHCG,RIC3,SCNN1B,SGK1,SLC12A4,SNCA,TACR1,TMTC2,TRPC6,VWF,WNK4",36]
[null,"Cell-To-Cell Signaling and Interaction","Binding of connective tissue cells",{"v":8.58e-05,"d":"8.58E-05"},"Decreased",-2.596,"APOE,BMP2,CCL2,CCN1,COL7A1,ITGA11,ITGA9,ITGAL,LAMA3,MATN3,PALLD,PMP22,POSTN,RUNX2,THBS2",15]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Lymphocyte migration",{"v":7.63e-05,"d":"7.63E-05"},"Decreased",-2.578,"ACKR3,ALOX5,APOE,C3,CBLB,CCL2,CD74,CTSV,CXCR2,DOCK8,ELMO1,EVL,GPR132,ITGA9,ITGAL,KLK5,P2RX7,PTPRB,RUNX1,SELE,SEMA3E,SERPINB3,SERPINE2,STAB1,THBS2,TNFRSF21",26]
[null,"Cellular Movement","Homing of cells",{"v":1.13E-5,"d":"1.13E-05"},"Decreased",-2.57,"A2M,ACKR3,ALOX5,APOE,BMP2,C3,CCL2,CCN1,CCN3,CD74,CXCR2,CYBB,DGKA,EGR3,ELMO1,EPHB2,F10,FGF7,FGFBP1,GJA1,GPR132,HBEGF,ITGA9,ITGAL,KDR,LIF,LSP1,MMP28,MYO1F,P2RY2,PDGFRA,PDGFRB,PLEKHG5,RGS5,RHOG,RUNX1,SELE,SEMA3E,THBS2,TRPC6",40]
[null,"Cell-To-Cell Signaling and Interaction","Activation of cells",{"v":1.8E-5,"d":"1.80E-05"},"Decreased",-2.552,"ACKR3,ALOX5,APOE,BMP2,C3,CBLB,CCDC88B,CCL2,CCN1,CCN3,CD300A,CD74,CD93,CEACAM6,CHI3L1,CXCR2,CYBB,DGKA,DGKG,DLL4,EGR3,EPHB2,F10,FOXD1,GIMAP6,GJA1,GRIK2,HBEGF,ITGAL,ITPR1,ITPR2,KAT2A,KDR,KRT2,LGALS4,LIF,LMOD1,LOXL2,LSP1,MMP19,P2RX7,P2RY2,PALLD,PBX3,PDGFRA,PDGFRB,PTH1R,RUNX1,RUNX2,SELE,SERPINE2,SMPD3,SNCA,SYBU,TACR1,TNFRSF21,TRPC6,TSPAN32,UNC13D,VWF",60]
[null,"Cellular Function and Maintenance,Molecular Transport","Flux of inorganic cation",{"v":7.26e-05,"d":"7.26E-05"},"Decreased",-2.531,"A2M,ADRB2,APOE,C3,CCL2,CD300A,CXCR2,CYBB,EGR1,EPHB2,ERG,GJA1,GPR132,NPPC,P2RX7,P2RY2,RIC3,SCNN1B,SGK1,SNCA,TRPC6,VWF,WNK4",23]
[null,"Cellular Movement,Immune Cell Trafficking","Cell movement of lymphatic system cells",{"v":8.29e-05,"d":"8.29E-05"},"Decreased",-2.52,"ACKR3,ADRB2,ALOX5,APOE,BMP2,C3,CBLB,CCL2,CD74,CTSV,CXCR2,DOCK8,ELMO1,EVL,FLT4,GPR132,ITGA9,ITGAL,KDR,KLK5,P2RX7,PTPRB,RUNX1,SELE,SEMA3E,SERPINB3,SERPINE2,STAB1,THBS2,TNFRSF21",30]
[null,"Cell-To-Cell Signaling and Interaction","Adhesion of connective tissue cells",{"v":1.01E-4,"d":"1.01E-04"},"Decreased",-2.399,"BMP2,CCL2,CCN1,COL7A1,ITGA11,ITGA9,ITGAL,LAMA3,MATN3,PALLD,PMP22,POSTN,RUNX2,THBS2",14]
[null,"Cardiovascular System Development and Function,Cellular Movement","Cell movement of endothelial cells",{"v":7.98e-07,"d":"7.98E-07"},"Decreased",-2.37,"ACKR3,ANPEP,APOE,BMP2,CCL2,CCN1,CXCR2,CYP1B1,DGKA,DIO2,DLL4,EGFL7,EGR1,EGR3,ERG,ESAM,FLT4,ITGA9,KDR,KIF26B,LOXL2,PDE2A,PDGFRB,PLEKHG5,PTH1R,SELE,SEMA3E,STAB1,THBS2,TNFRSF25,VASH1,VWF",32]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Migration of mononuclear leukocytes",{"v":1.11E-4,"d":"1.11E-04"},"Decreased",-2.32,"ACKR3,ALOX5,APOE,C3,CBLB,CCL2,CD300A,CD74,CTSV,CXCR2,DOCK8,ELMO1,EVL,GPR132,ITGA9,ITGAL,KLK5,P2RX7,PTPRB,RUNX1,SELE,SEMA3E,SERPINB3,SERPINE2,STAB1,THBS2,TNFRSF21",27]
[null,"Cellular Movement","Cell movement of blood cells",{"v":1.95e-08,"d":"1.95E-08"},"Decreased",-2.288,"ACKR3,ADD2,ADRB2,ADTRP,ALOX5,APOE,ARG1,BMP2,C3,CBLB,CCL2,CCN1,CD300A,CD74,CD93,CEACAM6,CHI3L1,CHST1,CLEC10A,CTSV,CXCR2,CYBB,CYP1B1,DOCK8,EEF1A2,EGFL7,EGR1,ELMO1,ESAM,EVL,F10,FLT4,GJA1,GPR132,HBEGF,ITGA9,ITGAL,KDR,KLK5,LAMA5,LIF,LSP1,MINK1,MMP28,MYO1F,NCF4,P2RX7,P2RY2,PTPRB,RASGRP2,RGS5,RUNX1,RUNX3,SELE,SEMA3E,SERPINB3,SERPINE2,SGK1,SLC7A5,SLC7A8,SOD3,STAB1,TACR1,THBS2,TNFRSF21,TRPC6,TSPAN15,TSPAN32,VWF",69]
[null,"Hematological System Development and Function","Hemostasis",{"v":9.86e-06,"d":"9.86E-06"},"Decreased",-2.278,"A2M,ABCB1,ADTRP,APOE,C3,CCL2,CYBB,DGKA,DGKG,DOCK8,EPHB2,F10,FLI1,GRIK2,ITPR1,ITPR2,P2RX6,P2RX7,PDGFRA,RASGRP2,SERPINE2,SGK1,THBS2,TRPC6,TSPAN32,VWF",26]
[null,"Cell-To-Cell Signaling and Interaction","Binding of tumor cell lines",{"v":1.99E-6,"d":"1.99E-06"},"Decreased",-2.267,"APOE,CCL2,CCN1,CCN3,CLCA2,CST6,CXCR2,CYBB,DOCK8,EGFL7,EGR1,EGR3,F10,GMFG,GRIA4,ITGA9,ITGAL,KLK5,LAMA3,LAMA5,LGALS4,LIF,MINK1,MMP19,P2RY2,PALLD,PARVG,RASGRP2,SELE,SERPINB3,SLC7A5,TNFRSF25",32]
[null,"Cell-mediated Immune Response,Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","T cell migration",{"v":9.04e-05,"d":"9.04E-05"},"Decreased",-2.194,"ACKR3,ALOX5,APOE,C3,CCL2,CD74,CTSV,CXCR2,DOCK8,ELMO1,ITGA9,ITGAL,KLK5,P2RX7,PTPRB,RUNX1,SELE,SERPINE2,STAB1,THBS2,TNFRSF21",21]
[null,"Cellular Movement,Hematological System Development and Function,Immune Cell Trafficking","Cell movement of leukocytes",{"v":5.14e-05,"d":"5.14E-05"},"Decreased",-2.173,"ACKR3,ADRB2,ALOX5,APOE,ARG1,C3,CBLB,CCL2,CCN1,CD300A,CD74,CD93,CHST1,CTSV,CXCR2,CYBB,DOCK8,EEF1A2,EGFL7,ELMO1,EVL,F10,GJA1,GPR132,ITGA9,ITGAL,KDR,KLK5,LAMA5,LSP1,MMP28,MYO1F,P2RX7,PTPRB,RGS5,RUNX1,RUNX3,SELE,SEMA3E,SERPINB3,SERPINE2,SGK1,SOD3,STAB1,TACR1,THBS2,TNFRSF21,TRPC6,TSPAN15,VWF",50]
[null,"Cellular Assembly and Organization,Tissue Development","Formation of filaments",{"v":0.000257,"d":"2.57E-04"},"Decreased",-2.167,"A2M,ADAMTS10,APOE,ARHGAP6,CCL2,CXCR2,DES,ESAM,EVL,FGF7,KDR,KIF17,LMOD1,MINK1,MSRB1,NEB,PALLD,PHLDB2,POSTN,PTPRB,SELE,SGK1,SNCA,STMN2,TACR1,TENM1,THSD4,TPM2,TRPC6",29]
[null,"Cellular Movement,Immune Cell Trafficking","Leukocyte migration",{"v":6.77e-08,"d":"6.77E-08"},"Decreased",-2.13,"ACKR3,ADD2,ADRB2,ADTRP,ALOX5,APOE,ARG1,BMP2,C3,CBLB,CCL2,CCN1,CD300A,CD74,CD93,CEACAM6,CHI3L1,CHST1,CLEC10A,CTSV,CXCR2,CYBB,CYP1B1,DOCK8,EEF1A2,EGFL7,EGR1,ELMO1,ESAM,EVL,F10,FLT4,GJA1,GPR132,HBEGF,ITGA9,ITGAL,KDR,KLK5,LAMA5,LIF,LSP1,MMP28,MYO1F,NCF4,P2RX7,P2RY2,PTPRB,RASGRP2,RGS5,RUNX1,RUNX3,SELE,SEMA3E,SERPINB3,SERPINE2,SGK1,SLC7A5,SLC7A8,SOD3,STAB1,TACR1,THBS2,TNFRSF21,TRPC6,TSPAN15,VWF",67]
[null,"Cell-To-Cell Signaling and Interaction","Interaction of tumor cell lines",{"v":5.41e-07,"d":"5.41E-07"},"Decreased",-2.107,"APOE,CCL2,CCN1,CCN3,CLCA2,CST6,CXCR2,CYBB,DOCK8,EGFL7,EGR1,EGR3,F10,GJA1,GJA3,GMFG,GRIA4,ITGA9,ITGAL,KLK5,LAMA3,LAMA5,LGALS4,LIF,MINK1,MMP19,P2RY2,PALLD,PARVG,RASGRP2,SELE,SERPINB3,SLC7A5,TNFRSF25",34]
[null,"Cell Morphology,Cellular Movement","Cell spreading",{"v":1.13E-4,"d":"1.13E-04"},"Decreased",-2.094,"A2M,C3,CCN1,CXCR2,ELMO1,GPR132,ITGA11,ITGA9,ITGAL,LAMA3,MINK1,PALLD,PARVG,PMP22,POSTN,RASGRP2,RHOG,RUNX1,THBS2,TSPAN32,VWF",21]
[null,"Cellular Movement","Cell movement of tumor cell lines",{"v":4.71e-06,"d":"4.71E-06"},"Decreased",-2.067,"A2M,ACKR3,ADAM33,ADRB2,ANPEP,BMP2,C3,CBLB,CCL2,CCN1,CCN3,CLDN7,CNN1,COL7A1,CST6,CXCR2,DOCK8,DPP10-AS1,EGR1,ELMO1,EPHB2,ERG,FGF7,FOXQ1,GJA1,GMFG,GPR132,H19,HBEGF,HMGCR,HOTAIRM1,ITGAL,ITPR1,KDR,LAMA3,LAMA5,LIF,LINC00672,MFNG,MINK1,MMP19,NEK3,NKD2,NR5A2,P2RY2,PALLD,PARVG,PDGFRA,POSTN,PRKN,PTPRU,RHOG,RUNX1,RUNX2,RUNX3,SELE,SEMA3C,SEMA3E,SERPINB3,SLC9A3R2,SPARCL1,TACR1,TBX3,THBS2,TNFRSF21,TNFRSF25",66]
[null,"Nervous System Development and Function","Sensory system development",{"v":1.11E-5,"d":"1.11E-05"},"Decreased",-2.062,"ADRB2,ALDH1A1,ALDH1A2,APOE,AQP1,ASPA,BMP2,C3,CCL2,CDC14B,CDHR1,CYP1B1,DLL4,EBF3,EGFLAM,EGR1,EPHB2,FGF7,FLT4,FOXD1,GJA3,HIF3A,HOXA3,HSF4,KDR,LIF,OTX1,RARB,RDH12,RGS11,RUNX3,SEMA3E,SHROOM4,SLC1A3,THBS2,WNT2B",36]
[null,"Cardiovascular System Development and Function,Cellular Movement","Migration of endothelial cells",{"v":9.67e-06,"d":"9.67E-06"},"Decreased",-2.01,"ACKR3,APOE,BMP2,CCL2,CCN1,CXCR2,CYP1B1,DIO2,DLL4,EGFL7,EGR1,EGR3,ERG,ESAM,FLT4,ITGA9,KDR,KIF26B,LOXL2,PDE2A,PDGFRB,PLEKHG5,PTH1R,SELE,SEMA3E,STAB1,TNFRSF25,VASH1",28]
[null,"Embryonic Development,Organismal Development","Development of body trunk",{"v":3.12e-05,"d":"3.12E-05"},"Decreased",-2.006,"ACKR3,ADRB2,ALDH1A1,ALDH1A2,ANKS6,ANPEP,APOE,AQP1,ARG2,BMP2,CACNB4,CCL2,CCN1,CCN3,CD74,CHI3L1,CXCR2,DLL4,DMRTA1,DNAH11,EGR1,EGR3,ERG,ESRRG,FAM20A,FGF7,FLI1,FLT4,FOXD1,GJA1,GRK5,HBEGF,HIF3A,HOXA3,HOXD9,HSD11B2,HSD17B2,ITGA11,ITGA8,ITGAL,KDR,LAMA5,LIF,LIMS2,LOXL2,LRP4,LRRC6,MEF2A,MEOX1,NAB1,NEB,NPPC,NR5A2,OSR2,OVOL2,PDE2A,PDGFRA,PDGFRB,PTH1R,RARB,RSPO1,RUNX1,RUNX2,RUNX3,SELE,SEMA3C,SMPD3,TBX3,TNNT2,VWF",70]
[null,"Organismal Injury and Abnormalities","Bleeding",{"v":6.73e-06,"d":"6.73E-06"},"Increased",3.191,"ACKR3,ADRB2,ALDH1A1,ALDH3A1,ALOX5,APOE,C3,CACNB4,CNN1,CYP2C19,ERG,F10,FLI1,FLT4,GABRE,GRIN2A,KAT2A,LIF,MINK1,OVOL2,PDGFRA,PDGFRB,RARB,RASGRP2,RUNX1,RXRG,SELE,SGK1,THBS2,TNFRSF21,TNNT2,UNC13D,VWF",33]
["A2 versus A3","Cancer,Organismal Injury and Abnormalities","Breast or colorectal cancer",{"v":1.34e-06,"d":"1.34E-06"},"Decreased",-2.607,"AATK,ABCA10,ABCA6,ABCA8,ABCA9,ACADVL,ACKR3,ACP5,ACP6,ACSL5,ADAMTS10,ADAMTS18,ADGRD1,ADGRF5,ADRB2,ADTRP,ALDH1A1,ANGPTL4,ANKRD6,ANO5,ANTXR2,APOC1,APOE,ARHGAP44,ATP6V1B1,ATP6V1C2,B2M,BCAS1,BNC2,C16orf96,C3orf70,CCDC102B,CCN2,CD200R1,CD69,CDCA5,CDH19,CDHR1,CEACAM5,CEACAM6,CELF2,CFAP69,CFTR,CHI3L1,CHI3L2,CIT,CLDN7,CLEC3B,CLSTN2,CNN1,CNNM1,COL6A6,COL7A1,COLEC12,CORO6,CRAT,CRISPLD1,CXCR2,CYP1B1,CYP27A1,CYP3A5,DCD,DCDC1,DDIT4,DGKG,DHCR7,DIO2,DIXDC1,DLG2,DLL4,DPP10-AS1,DUSP16,DUSP2,DZANK1,EBP,EEF1A2,EFNB2,EGFL7,EGR1,EGR3,ELOVL1,EMILIN3,EN1,F10,FA2H,FADS2,FAM83E,FASN,FAT4,FDPS,FGD5,FGF7,FLT4,FTX,FZD10,G6PD,GALNT12,GBP1,GJA1,GJA3,GLDC,GNB3,GPR132,GPX3,GREB1,GRK5,H19,H2AX,HACD2,HMGA1,HMGCR,HMGCS1,HOXD4,HPN,HSD11B2,HSD17B2,ICA1,IDH1,IL27RA,INSIG1,ITGA9,ITPR2,JAKMIP3,KANSL1L,KCNK5,KCNN4,KDR,KIF26B,KIT,KLHDC7B,KLHDC8B,KLHL41,KLK14,KRT2,KRT77,KRT79,KYAT1,LAMB4,LGALS3BP,LGI4,LHX2,LIF,LINC01139,LOC102724788/PRODH,LRP4,LSP1,LYG1,MACROD2,MAMDC2,MAPK8IP2,MFAP5,MFSD4A,MMP19,MMP7,MMP9,MVD,MVK,NDRG4,NEB,NFE2L3,NKD2,NLRP1,NOSTRIN,NRN1,NTM,OAS1,OR10AD1,OTX1,P2RY2,PBK,PCDH7,PDE10A,PDLIM4,PDZD4,PEX19,PGGHG,PGRMC1,PHLDB2,PLAT,PLCH2,PLEKHG5,PLIN2,PLLP,POSTN,PPARGC1A,PRR15L,PRRT2,PRUNE2,PTGFR,PTGIS,RAB3IL1,RAPGEF4,RARB,RASD2,RBM33,RHCG,RPP40,RPTN,RUNX1,RUNX3,SATB2,SCARA5,SCGB1D2,SCGB2A1,SCGB2A2,SELE,SEMA3C,SEMA3E,SEZ6L,SGK1,SGK2,SLC31A1,SLC35A2,SLC7A5,SLC9A3R2,SLCO4C1,SNRNP48,SOAT1,SPARCL1,STAB1,STAT1,STMN2,STRC,SULT2B1,SYNM,TBX3,TENM1,TF,TFPI,THBS2,THRSP,THSD4,TMEM97,TMPRSS2,TNNT2,TNNT3,TNXB,TPM2,TRERF1,TSHZ3,TSPAN15,TYMP,UBD,UBE2QL1,UGT1A6,UGT1A8 (includes others),UGT2A1,UIMC1,VENTX,VWF,WDR72,XDH,XKR4,ZDBF2",254]
[null,"Cellular Assembly and Organization,Tissue Development","Formation of filaments",{"v":0.000746,"d":"7.46E-04"},"Decreased",-2.429,"ACE,ADAMTS10,ADGRF5,APOE,ARHGAP6,CCN2,CXCR2,DIRAS3,FGF7,KDR,LMOD1,MSRB1,NEB,PAK3,PDLIM4,PHLDB2,PLAT,POSTN,PTPRB,SATB2,SELE,SGK1,SNCA,STMN2,SYNM,TENM1,THSD4,TPM2",28]
[null,"Embryonic Development,Organ Development,Organismal Development,Renal and Urological System Development and Function,Tissue Development","Formation of kidney",{"v":0.000538,"d":"5.38E-04"},"Decreased",-2.395,"ACE,APOE,ARG2,CFAP53,CXCR2,CYP27A1,FAT4,FGF7,FLT4,FOXD1,HSD17B2,KDR,LIF,LRP4,MMP9,PPARGC1A,RARB,SOX8,TKT,TSHZ3,XDH",21]
[null,"Cellular Assembly and Organization,Tissue Development","Fibrogenesis",{"v":0.000229,"d":"2.29E-04"},"Decreased",-2.323,"ACE,ADAMTS10,ADGRF5,APOE,ARHGAP6,CCN2,CXCR2,DIRAS3,FGF7,KDR,KLHL41,LIF,LMOD1,MSRB1,NEB,PAK3,PDLIM4,PHLDB2,PLAT,POSTN,PTPRB,SATB2,SELE,SGK1,SNCA,STAB1,STMN2,SYNM,TENM1,THSD4,TNNT2,TPM2",32]
[null,"Dermatological Diseases and Conditions,Organismal Injury and Abnormalities","Keratosis",{"v":6.63e-08,"d":"6.63E-08"},"Decreased",-2.236,"ABHD5,APOE,DGAT2,FDPS,G6PD,GJA1,IDH1,KRT9,ME1,MVD,MVK,PGD,PMVK,RSPO1,SOAT1,SRXN1,STAT1,TKT",18]
[null,"Cancer,Organismal Injury and Abnormalities","Breast or pancreatic cancer",{"v":3.51e-09,"d":"3.51E-09"},"Decreased",-2.2,"AATK,ABCA10,ABCA8,ABCA9,ABHD12B,ABHD6,ACADVL,ACAT2,ACKR3,ACO1,ACP5,ACSM3,ADAMTS10,ADAMTS18,ADGRD1,ADGRF5,ADRB2,ALDH1A1,ANKRD6,APOC1,APOE,ARG2,ARHGAP44,ATP6V1B1,B2M,C3orf70,CCN2,CCN3,CD69,CDH19,CDHR1,CEACAM6,CELF2,CFAP91,CFTR,CHI3L1,CHI3L2,CIT,CLDN7,CLEC3B,CLSTN2,CNN1,CNNM1,COL6A6,COL7A1,COLEC12,CORO6,CRAT,CRISPLD1,CXCR2,CYP3A5,DCD,DCDC1,DDIT4,DGKG,DHCR24,DHCR7,DIO2,DIRAS3,DIXDC1,DLG2,DLL4,DUSP16,DUSP2,DZANK1,EBP,EEF1A2,EFNB2,EGR1,EGR3,ELOVL1,EN1,F10,FADS2,FADS6,FASN,FAT4,FDPS,FGD5,FGD6,FGF7,FLT4,FOXD3,GABRP,GALNT12,GLDC,GNB3,GPR132,GPX3,GREB1,H19,H2AX,HMGA1,HMGCR,HMGCS1,HPN,HSD11B2,ICA1,ICAM5,IDH1,IFI30,IKZF3,IL16,IL27RA,INSYN2B,ITGA9,ITPR2,JAKMIP3,KANSL1L,KDR,KIF26B,KIT,KLHDC8B,KLK14,KRT23,KRT27,KRT86,KRT9,LGALS3BP,LGI4,LIF,LINC01139,LNX1,LRP4,LSP1,MACROD2,MAGI3,MAMDC2,MEOX1,MFAP5,MINDY4,MMP19,MMP7,MMP9,MVD,MYH3,NEB,NFE2L3,NLRP1,NOSTRIN,NR1H3,NR5A2,NRBP2,NRN1,NTM,NUAK2,OR10AD1,OTUB2,OTX1,P2RY2,PCDH7,PDE10A,PDE3B,PDLIM4,PDZD4,PEX19,PGGHG,PHLDB2,PHYKPL,PLAT,PLCH2,PLIN2,PNPLA5,POSTN,PPARGC1A,PRR15L,PRUNE2,PTGIS,PTPRB,RAB3IL1,RAPGEF4,RARB,RBM33,RPTN,RUNX1,RUNX3,S100A7,SATB2,SCGB1D2,SCGB2A1,SCGB2A2,SELE,SEMA3C,SEMA3E,SGIP1,SH3BP2,SLC19A3,SLC31A1,SLC35A2,SNRNP48,SOX8,STAB1,STAT1,SYNM,TBX18,TBX3,TF,TFPI,THBS2,THEG,THRSP,TMEM132B,TMEM91,TMEM97,TNNT2,TNNT3,TNXB,TPM2,TPPP3,TRERF1,TSHZ3,TSPAN15,TYMP,UBE2QL1,UGT2A1,UIMC1,VWF,WDR19,XDH,ZDBF2,ZNF112",221]
[null,"Organismal Development","Development of genitourinary system",{"v":0.000129,"d":"1.29E-04"},"Decreased",-2.165,"ACE,AGPAT1,ALDH1A1,ANGPTL4,APOE,ARG2,BCAP31,CCN2,CFAP53,CFTR,CIT,CLDN11,CXCR2,CYP27A1,DHCR24,DIO2,DIRAS3,EGR1,EN1,FADS2,FASN,FAT4,FGF7,FLT4,FOXD1,FOXD3,GAL,GJA1,H19,H2AX,HMGA1,HOXD9,HSD17B2,INSIG1,KDR,KIT,LIF,LRP4,LRRC6,MMP19,MMP9,NR1H3,NR5A2,PDE3B,PLIN2,PPARGC1A,RARB,RSPO1,SOX8,TBX3,TF,THEG,THRSP,TKT,TSHZ3,UGT8,VWF,WDR19,XDH",59]
[null,"Carbohydrate Metabolism,Lipid Metabolism,Molecular Transport,Small Molecule Biochemistry","Concentration of colfosceril palmitate",{"v":8.43e-06,"d":"8.43E-06"},"Increased",2,"ELOVL1,FASN,INSIG1,THRSP",4]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Hydrolysis of acylglycerol",{"v":6.49e-06,"d":"6.49E-06"},"Increased",2.035,"ABHD5,ABHD6,ANGPTL4,APOE,ELOVL5,PLA2G7,PLIN2,SNCA",8]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Metabolism of acylglycerol",{"v":3.55e-07,"d":"3.55E-07"},"Increased",2.094,"ABHD5,ABHD6,ACSL1,ACSL5,ALDH1A1,APOE,DGAT2,FASN,FITM2,INSIG1,KIT,NR1H3,PCTP,PLIN2,PNPLA5,PPARGC1A,THRSP,TNXB",18]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Fatty acid metabolism",3.09E-12,"Increased",2.098,"ABCA8,ACAA2,ACADL,ACADVL,ACSL1,ACSL5,ACSM3,ALOX15B,ANGPTL4,APOC1,APOE,ATP6V1B1,AWAT1,AWAT2,CFTR,CPT2,CRAT,CYP1B1,CYP27A1,EGR1,ELOVL1,ELOVL3,ELOVL5,FA2H,FADS1,FADS2,FAR2,FASN,HACD2,HAO2,IL16,INSIG1,KCNN4,KIT,LIF,MCAT,ME1,MKNK1,MMP7,MSMO1,NR1H3,PCTP,PLIN2,PPARGC1A,PTGIS,RARB,RUNX1,SLC35A2,SLC9A3R2,SNCA,SOAT1,THRSP,TNXB,UGT1A8 (includes others),UGT8,VWF",56]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Synthesis of triacylglycerol",{"v":3.39E-7,"d":"3.39E-07"},"Increased",2.176,"ACSL1,ACSL5,ALDH1A1,APOE,DGAT2,FASN,FITM2,NR1H3,PCTP,PLIN2,PPARGC1A,THRSP",12]
[null,"Amino Acid Metabolism,Small Molecule Biochemistry","Metabolism of amino acids",{"v":0.000717,"d":"7.17E-04"},"Increased",2.2,"ACAD8,ARG2,ASPA,CSAD,DIO2,EGR1,GLDC,GPT,IDH1,KYAT1,LOC102724788/PRODH,ME1,PHYKPL,SLC5A6,TST",15]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Conversion of lipid",{"v":3.4e-06,"d":"3.40E-06"},"Increased",2.215,"ABHD5,ALOX15B,ANGPTL4,APOE,CFTR,CRAT,CYP1B1,DHCR24,FADS1,FASN,HMGCR,HSD11B2,HSD17B2,HSD3B1,PTGIS,SNCA",16]
[null,"Lipid Metabolism,Molecular Transport,Small Molecule Biochemistry","Secretion of sterol",{"v":1.99e-05,"d":"1.99E-05"},"Increased",2.219,"ACAT2,APOE,LPCAT3,NR1H3,PCTP,SOAT1",6]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Metabolism of membrane lipid derivative",{"v":1.67e-15,"d":"1.67E-15"},"Increased",2.252,"A4GALT,ABCA8,ABHD5,ABHD6,ACAT2,ACER1,ACP6,ACSL5,ADRB2,AGPAT1,AGPAT3,ALDH3B2,APOC1,APOE,ASPA,CERS4,CFTR,CYP1B1,CYP27A1,DHCR24,DHCR7,EBP,ELOVL1,FA2H,FADS1,FASN,FDPS,FGF7,G6PD,GPD1,HACD2,HMGCR,HMGCS1,HSD17B2,INSIG1,KDR,KIT,MSMO1,MVD,MVK,NR1H3,PCTP,PGRMC1,PLA2G7,PLCH2,PMVK,SGPP2,SLC35A2,SNCA,SOAT1,SULT2B1,TM7SF2,UGT8,XDH",54]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Metabolism of triacylglycerol",{"v":6.12e-08,"d":"6.12E-08"},"Increased",2.417,"ABHD5,ACSL1,ACSL5,ALDH1A1,APOE,DGAT2,FASN,FITM2,INSIG1,NR1H3,PCTP,PLIN2,PNPLA5,PPARGC1A,THRSP,TNXB",16]
[null,"Lipid Metabolism,Small Molecule Biochemistry","Synthesis of lipid",2.47E-24,"Increased",2.438,"A4GALT,ABCA8,ABHD5,ABHD6,ACADL,ACADVL,ACAT2,ACER1,ACP6,ACSL1,ACSL5,ACSM3,ADRB2,AGPAT1,AGPAT3,ALDH1A1,ALDH3B2,ALOX15B,ANGPTL4,APOC1,APOE,ASPA,AWAT1,AWAT2,CERS4,CFTR,CYB5A,CYP1B1,CYP27A1,CYP2R1,DGAT2,DHCR24,DHCR7,DHRS11,EBP,EGR1,ELOVL1,ELOVL3,ELOVL5,FA2H,FADS1,FADS2,FAR2,FASN,FDPS,FGF7,FITM2,G6PD,GBGT1,GPD1,HACD2,HMGCR,HMGCS1,HSD11B2,HSD17B2,HSD3B1,IDH1,IL16,INSIG1,KDR,KIT,LIF,MCAT,ME1,MKNK1,MMP9,MSMO1,MVD,MVK,NR1H3,NR5A2,PCTP,PDE3B,PGD,PGRMC1,PLIN2,PMVK,PPARGC1A,PTGIS,RARB,RUNX1,SGPP2,SLC35A2,SLC9A3R2,SNCA,SOAT1,THRSP,TM7SF2,TRERF1,UGT8,VWF,XDH",92]
[]
["A1 – Periorbital area (crow’s feet); A2 – Preauricular area (wrinkle-free); A3 - Gluteal area; DE - Differentially Expressed."]