{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["Sheet1"],"read":"whole","date_system":"1900"}

{"sheet":"Sheet1","index":0,"n_rows":1105,"n_cols":4,"rows_kept":1105,"merged":[[0,0,0,3]]}
["Supplemtary Data 2. Differentially expressed genes after Smad1 KO (KO vs NC)"]
["Genes","p value","Regulation","FC "]
["ABCA1",0.007547211,"down",1.5834357]
["ABCA1",0.003268963,"down",1.556459]
["ABCC2",{"v":4.37E-4,"d":"4.37E-04"},"down",3.8089008]
["ABCE1",0.02323596,"down",1.6938984]
["ABHD17B",0.042064846,"down",1.504767]
["ABHD17C",0.047830388,"down",1.541202]
["ABI3BP",0.020828556,"down",1.5701156]
["ACPP",0.022704752,"down",1.598548]
["ACR",0.012457756,"down",2.4176614]
["ACTN3",0.026744433,"down",1.661974]
["ACTR3C",0.04061455,"down",2.2954814]
["ADAM19",0.03509479,"down",2.2124348]
["ADAM19",0.046061024,"down",1.6429744]
["ADO",0.043554246,"down",1.618249]
["AGER",0.04335491,"down",1.5113333]
["AIG1",0.006888143,"down",1.5421497]
["AJAP1",0.020355778,"down",2.516823]
["AK4",0.01851685,"down",1.7230967]
["ALDH3B2",0.012925697,"down",1.7383884]
["ALDH5A1",0.006755045,"down",2.0091338]
["ALDH7A1",0.001957527,"down",1.8924031]
["ALDH9A1",0.044787437,"down",1.5010598]
["ALG10",0.03968717,"down",1.7476654]
["ALPK3",0.011755152,"down",3.7289042]
["ANGPTL1",0.042847056,"down",1.636726]
["ANKDD1B",0.03028891,"down",2.5706952]
["ANKRD11",0.03922148,"down",1.8953851]
["ANKRD18B",0.02014239,"down",2.1526103]
["ANKRD23",0.028058946,"down",2.076914]
["ANKRD49",0.036242615,"down",1.5806822]
["ANKRD6",0.041502785,"down",2.9328709]
["ANP32A",0.029501596,"down",2.1043487]
["ANP32E",0.011236021,"down",1.5025533]
["ANP32E",0.006959288,"down",1.5541677]
["APOLD1",0.029433323,"down",1.7063483]
["APOM",0.008223615,"down",1.5367366]
["AREG",0.021388082,"down",1.8022751]
["ARHGAP11A",0.010066971,"down",1.6725161]
["ARHGAP11B",0.026065899,"down",1.542536]
["ARHGAP24",0.039113495,"down",1.9286544]
["ARHGEF17",0.004475195,"down",1.603949]
["ARL13A",0.030903567,"down",2.270472]
["ASIC1",0.007786407,"down",1.780047]
["ASPH",0.006542136,"down",1.5100266]
["ATHL1",0.008271267,"down",2.3827457]
["ATOH8",0.008769302,"down",4.07444]
["ATP13A4",{"v":0.000266,"d":"2.66E-04"},"down",4.7336063]
["ATP5L2",0.021974768,"down",1.6261543]
["BCKDHB",0.03793403,"down",1.8667318]
["BCOR",0.001074501,"down",1.8641982]
["BEGAIN",{"v":2.02E-4,"d":"2.02E-04"},"down",1.8012972]
["BHLHE41",0.014521071,"down",1.6506158]
["BID",0.026064401,"down",1.5559076]
["BIRC2",2.245936E-3,"down",2.0019987]
["BLID",0.028593121,"down",1.5315558]
["BSN",2.663403E-3,"down",3.681148]
["C10orf128",7.734136E-3,"down",1.5232084]
["C12orf57",0.03327446,"down",1.5906292]
["C12orf60",0.012344285,"down",3.4654322]
["C12orf76",0.034352917,"down",1.9062263]
["C17orf82",0.020198543,"down",1.7272477]
["C19orf60",0.04484956,"down",1.5268214]
["C1orf74",0.017875856,"down",1.5548203]
["C1RL",0.038442984,"down",1.6948118]
["C2orf15",0.009622225,"down",1.520875]
["C2orf69",0.044234,"down",1.5805004]
["C4orf22",{"v":0.00021,"d":"2.10E-04"},"down",2.0583906]
["C5",0.017845958,"down",1.531999]
["C6orf132",0.014308908,"down",2.6566415]
["C8B",0.020169446,"down",2.2823248]
["C9orf139",0.04531732,"down",2.7111578]
["C9orf3",0.02201158,"down",1.6275507]
["C9orf43",0.042757463,"down",2.0967898]
["C9orf92",0.016892226,"down",3.7925475]
["CA3",0.019663317,"down",4.1218085]
["CACNA1D",0.020929316,"down",3.4069078]
["CACNA2D3",0.014233331,"down",3.840832]
["CAMK1D",0.036843676,"down",1.5003489]
["CAND1",2.973739E-3,"down",1.5950515]
["CASC4",0.016081953,"down",1.8977672]
["CCDC129",0.04402489,"down",1.6025232]
["CCDC170",0.045924805,"down",1.5203615]
["CCDC176",0.03227518,"down",1.5022951]
["CCDC36",0.010326339,"down",4.439337]
["CCL14",0.015038,"down",2.9677284]
["CCL23",0.048740912,"down",1.8443042]
["CCNC",0.027738707,"down",1.5617739]
["CD1B",0.02574915,"down",3.6545017]
["CD274",0.029887028,"down",1.7609848]
["CD274",0.031796593,"down",1.5614998]
["CD33",0.001226582,"down",1.9430667]
["CD40",0.009706214,"down",2.0714514]
["CD6",0.001722565,"down",2.3469622]
["CD8B",0.013519779,"down",3.8897076]
["CD8B",0.025824923,"down",1.5233136]
["CDCA7",0.041235477,"down",1.8180681]
["CDH9",0.041460335,"down",1.6905638]
["CELSR1",0.0368093,"down",2.4443674]
["CFHR3",0.022789415,"down",1.6811787]
["CGB5",5.893611E-3,"down",1.9537632]
["CHAF1B",{"v":2.19E-5,"d":"2.19E-05"},"down",1.6496329]
["CHD6",0.048432853,"down",1.5084653]
["CHFR",0.028136583,"down",3.2497745]
["CHI3L1",0.010637587,"down",1.89712]
["CHRFAM7A",0.024853235,"down",1.5065296]
["CHRNA4",0.006155131,"down",2.2222555]
["CHTF18",0.041516755,"down",1.5302569]
["CKAP4",0.016853316,"down",1.5769521]
["CLDN20",{"v":0.000628,"d":"6.28E-04"},"down",2.985478]
["CLEC1B",0.0344606,"down",3.4675026]
["CNTLN",0.020477612,"down",2.2345586]
["CNTRL",0.041252207,"down",1.7669718]
["COL15A1",0.039210744,"down",1.5651752]
["COL1A1",0.0198707,"down",2.6668625]
["COL4A3",0.04140528,"down",3.2698512]
["COLQ",0.017973883,"down",2.3470035]
["CPNE9",0.014789252,"down",2.6976757]
["CREB1",0.011214493,"down",1.9238088]
["CRNKL1",0.021215338,"down",1.5593507]
["CSTA",0.009376632,"down",2.881209]
["CTBS",0.031343546,"down",1.6278235]
["CTBS",0.010095156,"down",1.6215155]
["CTPS2",0.019486066,"down",1.839943]
["CTSS",0.042999357,"down",1.9642645]
["CWC22",0.007582166,"down",1.5809778]
["CWH43",0.030383643,"down",2.3800457]
["CXorf67",{"v":1.14e-05,"d":"1.14E-05"},"down",7.5658603]
["CYP39A1",0.030748291,"down",2.8294551]
["CYP4A11",0.009303652,"down",1.68761]
["DAW1",{"v":0.000921,"d":"9.21E-04"},"down",1.5067362]
["DCAF6",{"v":0.000712,"d":"7.12E-04"},"down",1.6545523]
["DCBLD1",0.001433537,"down",1.6495844]
["DCP2",0.047307953,"down",1.5150439]
["DDAH2",0.02474437,"down",1.5693156]
["DDX26B",0.027383784,"down",1.6579063]
["DDX3Y",0.024362238,"down",1.9055755]
["DENND5B",0.029027661,"down",1.6615576]
["DGKE",0.022779146,"down",1.6033648]
["DHRS12",0.003971344,"down",2.2328804]
["DHRS2",0.024441957,"down",3.3281748]
["DHRS3",0.004262557,"down",2.7242136]
["DIRAS3",0.037558533,"down",2.4408991]
["DLX2",0.029379874,"down",1.8078982]
["DNAH14",0.010033828,"down",3.6101794]
["DNAJC4",0.018155934,"down",1.6847131]
["DNMT1",0.042648446,"down",1.7691838]
["DOCK8",0.04868406,"down",1.7604868]
["DPY19L2",0.011592764,"down",1.531746]
["DSC3",0.027332215,"down",2.4681785]
["DST",0.040840957,"down",1.5780752]
["DTNBP1",{"v":0.000482,"d":"4.82E-04"},"down",2.2175164]
["DUT",0.001530033,"down",1.5262638]
["DYNLT1",0.023426238,"down",1.5205872]
["E2F2",0.040565852,"down",1.5924246]
["E2F3",0.001428774,"down",1.7017007]
["EBLN2",0.01405711,"down",1.5345163]
["EHD3",0.006628154,"down",1.5072099]
["EIF2AK2",0.02259065,"down",1.5596182]
["ELAVL2",0.04906176,"down",1.6758645]
["ELOVL1",{"v":7.72e-05,"d":"7.72E-05"},"down",2.1349044]
["ENAH",0.01868269,"down",2.2870374]
["ENAH",0.002604572,"down",1.5098284]
["ENO4",0.017635709,"down",2.9884048]
["ENPP2",0.016032463,"down",1.6093138]
["EPHB4",0.001469313,"down",1.8795419]
["EPHB4",0.008180266,"down",2.5028195]
["EPSTI1",0.017294677,"down",2.4112766]
["ERCC4",0.02177586,"down",2.0666537]
["ERRFI1",0.014428876,"down",1.5013465]
["ESCO2",0.016226696,"down",1.5205028]
["ESR1",0.020927029,"down",2.3895602]
["ETNK1",0.03919305,"down",1.7460418]
["ETS2",0.004571831,"down",1.583149]
["ETV1",0.016896438,"down",1.539767]
["EYA1",0.035607707,"down",1.5866529]
["F3",0.04881097,"down",2.1535091]
["F8A1",0.001342376,"down",1.6428783]
["FABP7",0.016252682,"down",4.905302]
["FAM122C",0.026336677,"down",1.672405]
["FAM127C",0.005265871,"down",1.6242893]
["FAM151B",0.035507213,"down",1.7422981]
["FAM156B",0.039526865,"down",1.5455981]
["FAM160A1",0.048258997,"down",1.557289]
["FAM185A",0.005144869,"down",1.6841241]
["FAM196B",0.003217593,"down",1.540383]
["FAM25A",0.036142945,"down",3.189042]
["FAM43B",0.011724672,"down",2.057194]
["FAM46A",0.043436114,"down",1.8138826]
["FAM46A",0.010511936,"down",1.8567853]
["FAM47A",0.001440692,"down",2.142937]
["FBLN5",2.043319E-3,"down",2.0309472]
["FCHSD2",0.01993196,"down",1.7834916]
["FCRLA",0.02225405,"down",1.5281416]
["FDXACB1",0.027700191,"down",1.8003116]
["FERMT1",0.022922272,"down",1.6055964]
["FERMT2",0.034961525,"down",1.8479928]
["FGD3",0.002891169,"down",4.1049857]
["FGFR1OP",0.030636892,"down",1.5398053]
["FGFR1OP2",0.012364156,"down",1.8200142]
["FGFRL1",0.002210041,"down",1.5047435]
["FILIP1",0.027979981,"down",1.8183936]
["FKBP7",0.014957809,"down",1.5397701]
["FN1",0.007837685,"down",2.3563583]
["FOLR3",0.040831726,"down",2.929075]
["FRMD3",0.004549752,"down",1.8249797]
["FXYD3",0.015001111,"down",3.218247]
["FYB",0.004303527,"down",2.0326827]
["FZD7",0.025380332,"down",2.8092723]
["GALNT5",0.02462241,"down",1.7445143]
["GAMT",0.003434534,"down",1.6511669]
["GATA2",0.040748507,"down",2.5420985]
["GCSAML",0.019504564,"down",2.1673992]
["GK",0.006775482,"down",1.5970551]
["GLCCI1",0.04201768,"down",1.5047258]
["GLDN",1.989251E-3,"down",3.8480933]
["GLI2",0.002215096,"down",1.803803]
["GLI2",0.007823332,"down",1.6494176]
["GLIPR1",0.018438056,"down",1.5956612]
["GLIPR2",0.011930802,"down",1.8258014]
["GLUL",2.516791E-3,"down",2.204924]
["GML",{"v":0.000218,"d":"2.18E-04"},"down",1.857641]
["GNAS",0.047709282,"down",1.7219182]
["GNG2",0.029022006,"down",1.5881011]
["GOLGA8A",0.042019103,"down",1.7591523]
["GOPC",0.005982753,"down",1.6735773]
["GPR139",2.946532E-3,"down",6.639487]
["GPR157",0.026209425,"down",1.574473]
["GPR4",0.048597686,"down",2.4295995]
["GPR6",0.01626529,"down",3.522066]
["GRAMD1B",3.409844E-3,"down",1.7515086]
["GREB1",0.006584676,"down",2.2102084]
["GRIP1",2.09318E-3,"down",1.5008831]
["GSG1L",0.041581728,"down",2.248349]
["GTF3C6",9.884215E-3,"down",1.739254]
["H2AFV",0.03165696,"down",1.7805637]
["HAS1",0.026973516,"down",1.9887925]
["HAS1",0.028785396,"down",1.8955518]
["HAS1",0.021814346,"down",2.1430602]
["HAUS5",0.008824586,"down",1.5570898]
["HCFC2",0.001283322,"down",2.1329443]
["HERC1",0.024203086,"down",1.5289459]
["HFE",0.026487311,"down",1.5029502]
["HHIPL2",0.04565341,"down",2.4008825]
["HIF3A",0.028791629,"down",2.1590328]
["HIRIP3",0.019173995,"down",1.6596048]
["HIST1H1A",1.303263E-3,"down",1.5992852]
["HIST1H1B",0.00762298,"down",1.5491434]
["HIST1H1E",0.007936056,"down",1.5053762]
["HIST1H3D",0.006678697,"down",1.664385]
["HIST1H3H",{"v":5.04E-4,"d":"5.04E-04"},"down",1.588029]
["HIST1H3J",0.005536016,"down",1.5183011]
["HLA-DPA1",0.046511374,"down",1.6217085]
["HLA-DPB1",0.009844033,"down",1.78605]
["HLA-DPB1",0.00975047,"down",1.7740157]
["HLA-DPB1",0.005244999,"down",2.0601583]
["HLA-DPB1",0.037461355,"down",1.6592225]
["HLA-DRA",0.014428223,"down",2.683184]
["HNRNPA1",{"v":7.73e-05,"d":"7.73E-05"},"down",1.5919431]
["HPSE",0.023901109,"down",2.2683358]
["HSBP1L1",{"v":0.000792,"d":"7.92E-04"},"down",3.8214014]
["HSPB11",0.006918934,"down",1.5407649]
["HSPG2",0.014967219,"down",1.9095786]
["HTRA1",0.021362133,"down",1.5566194]
["HTRA3",0.030351846,"down",1.9554724]
["HYPM",0.035763457,"down",1.9304621]
["ID1",0.01367583,"down",2.3808193]
["ID2",0.005833013,"down",2.753003]
["ID2",0.007463196,"down",3.6307442]
["ID3",0.03453426,"down",2.1896396]
["IFI44L",0.003581158,"down",1.855004]
["IGFBP4",0.011796221,"down",2.672183]
["IKZF2",0.0374958,"down",2.1623363]
["IL24",0.0138607,"down",2.2037127]
["INMT",0.008747267,"down",4.1873274]
["INTS6",0.02131312,"down",1.5201585]
["IPCEF1",2.50235E-3,"down",2.9635108]
["IQCA1",0.03806393,"down",2.446509]
["IQCJ-SCHIP1",0.006401293,"down",2.0435288]
["IRX3",0.036671296,"down",2.0246742]
["ITGA2",0.013559248,"down",1.9643464]
["ITGA6",4.748637E-3,"down",4.8378377]
["IVNS1ABP",0.01998496,"down",1.7320825]
["IVNS1ABP",3.422067E-3,"down",1.6437811]
["JPH4",0.024619592,"down",4.0500517]
["KALRN",0.04276845,"down",2.3836827]
["KANK1",0.03693004,"down",1.7881045]
["KCNA7",0.010027655,"down",3.36944]
["KCNIP1",0.04559078,"down",2.8630064]
["KCNJ15",0.002854235,"down",1.6950555]
["KCNK9",0.010931307,"down",2.0781033]
["KCNMB4",0.004349834,"down",2.0074909]
["KCNRG",0.027878648,"down",1.6710116]
["KCTD18",0.028752608,"down",1.5596347]
["KCTD21-AS1",0.02487542,"down",1.7999748]
["KDM4C",0.03219033,"down",1.7014673]
["KIAA0040",0.025017679,"down",2.529964]
["KIAA0754",0.018409366,"down",1.5741141]
["KIAA1661",0.013240583,"down",1.6817]
["KIAA1958",0.004239519,"down",2.717233]
["KIF1B",0.044028457,"down",1.5457739]
["KLB",0.037036605,"down",1.5815655]
["KNCN",{"v":7.76E-4,"d":"7.76E-04"},"down",4.900721]
["KPNA1",0.019563287,"down",2.8897612]
["KRT75",{"v":0.000527,"d":"5.27E-04"},"down",3.0734515]
["KRTAP25-1",{"v":0.000276,"d":"2.76E-04"},"down",1.5952413]
["KRTCAP3",4.625199E-3,"down",3.5696733]
["LAMA4",0.002820575,"down",1.5664473]
["LAMA4",0.011749924,"down",1.8184094]
["LAYN",0.039828073,"down",2.092905]
["LFNG",{"v":2.31E-4,"d":"2.31E-04"},"down",1.7821884]
["LIMK1",0.039892104,"down",1.6835915]
["LINC00113",6.631344E-3,"down",2.5834427]
["LOC100128001",0.03743476,"down",1.788044]
["LOC100128019",0.02098487,"down",2.0988786]
["LOC100128108",0.03262783,"down",2.0614462]
["LOC100128320",0.006973578,"down",2.6312878]
["LOC100128591",0.00115793,"down",1.6150159]
["LOC100128979",0.029468438,"down",1.8885784]
["LOC100129399",0.025572337,"down",1.8000462]
["LOC100131829",0.026232174,"down",1.5913208]
["LOC100132014",0.016414518,"down",1.9555389]
["LOC100291323",0.01758895,"down",2.2244356]
["LOC100506922",0.03708399,"down",2.090961]
["LOC100506922",0.016759984,"down",1.9434131]
["LOC100653061",7.188201E-3,"down",1.740396]
["LOC100996724",0.013602608,"down",1.5039554]
["LOC349160",0.024587398,"down",2.3619456]
["LOX",0.011059142,"down",2.2867646]
["LOXHD1",0.005477665,"down",2.0829585]
["LOXL2",0.041974433,"down",1.7089767]
["LOXL3",0.016746031,"down",1.5538899]
["LRRC10B",0.014280255,"down",3.5873947]
["LRRC15",0.003945648,"down",2.3052628]
["LRRC17",0.041008234,"down",2.2988465]
["LRRC61",0.026690628,"down",2.8233657]
["LRRIQ4",0.021419246,"down",1.5817198]
["LY6E",{"v":0.000878,"d":"8.78E-04"},"down",1.7469233]
["MAB21L1",0.026645657,"down",1.601075]
["MAGEC2",0.039007895,"down",2.120651]
["MAGEH1",0.007622007,"down",1.6285021]
["MAGOH",0.012089035,"down",1.5359844]
["MAP3K15",0.026027773,"down",1.6782513]
["MAP3K2",0.03366037,"down",1.9791683]
["MAP3K9",0.010682697,"down",2.0566027]
["MAP6",0.022544837,"down",1.7732811]
["MARCKSL1",0.005489712,"down",1.9733268]
["MATN2",{"v":0.000974,"d":"9.74E-04"},"down",2.1450543]
["MBD5",0.04055288,"down",1.6547464]
["MCM6",0.00509537,"down",1.6436713]
["MCTP2",0.011157529,"down",1.8823012]
["MDM1",5.067144E-3,"down",1.6224601]
["MED14OS",0.037476566,"down",1.7210414]
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["TTC23L",0.006706143,"up",1.6419522]
["TTC39A",0.028428854,"up",1.6811137]
["TUBAL3",0.03740054,"up",6.132477]
["ULK2",0.044859808,"up",1.5191736]
["UNC79",0.019823719,"up",1.6649033]
["USP29",0.03942393,"up",1.5761089]
["VSTM1",0.038316082,"up",1.7237085]
["VTI1A",0.020619707,"up",1.5177423]
["WAS",0.01863302,"up",4.231061]
["WFDC11",0.004513645,"up",1.8392383]
["WFDC2",0.018250678,"up",1.6760647]
["WNT1",0.028135173,"up",3.5596259]
["ZFPM2",0.04692505,"up",1.5465305]
["ZIM2",0.02547696,"up",1.9315698]
["ZNF28",0.00227365,"up",1.5460852]
["ZNF285",0.001781252,"up",1.7902415]
["ZNF333",0.049717702,"up",1.7613131]
["ZNF43",0.020577298,"up",1.8728626]
["ZNF461",0.007825531,"up",1.635222]
["ZNF471",0.047698136,"up",1.9442185]
["ZNF485",0.04639849,"up",1.5081896]
["ZNF497",0.021725807,"up",2.143916]
["ZNF568",0.02742407,"up",2.4819198]
["ZNF585B",0.015526724,"up",3.1245985]
["ZNF585B",0.02089882,"up",2.4970696]
["ZNF677",0.005376242,"up",2.9665816]
["ZNF701",{"v":0.000613,"d":"6.13E-04"},"up",1.542507]
["ZNF720",0.023834469,"up",1.820764]
["ZNF750",0.03542656,"up",1.6409678]
["ZNF812",0.03820929,"up",2.9400754]
["ZNF90",0.005895986,"up",1.7723674]