{"text_format":"3","workbook":"xlsx","n_sheets":3,"sheets":["Table S1","Table S2","Table S3"],"not_rendered":{"defined_names":2},"read":"whole","date_system":"1900"}

{"sheet":"Table S1","index":0,"n_rows":64,"n_cols":8,"rows_kept":64,"merged":[[2,0,4,0],[5,0,7,0],[8,0,10,0],[11,0,13,0],[14,0,16,0],[17,0,19,0],[20,0,22,0],[23,0,25,0],[26,0,28,0],[29,0,31,0],[32,0,34,0],[35,0,37,0],[38,0,40,0],[41,0,43,0],[44,0,46,0],[47,0,49,0],[50,0,52,0],[53,0,55,0],[56,0,58,0],[59,0,61,0]]}
["Table S1. Logistic regression and meta-analysis between the PRSs for the top 20 gut microbiota genera and AD diagnosis in discovery and replicate samples. "]
["Trait","Samples","Coeff.","SE","z-value","P","OR(95%CI)","N"]
["Adlercreutzia","ADc12",-0.145,0.041,{"v":-3.57,"d":"-3.570"},{"v":0.00035698,"d":"3.57E-04"},"0.86(0.80-0.94)",2571]
[null,"ADA",-0.104,0.051,-2.063,{"v":0.039127066,"d":"3.91E-02"},"0.90(0.82-0.99)",1577]
[null,"meta-analysis",-0.129,0.032,-4.038,{"v":5.40066273133081e-05,"d":"5.40E-05"},"0.88(0.83-0.94)",4148]
["Alistipes","ADc12",0.157,{"v":0.04,"d":"0.040"},3.881,{"v":1.04106E-4,"d":"1.04E-04"},"1.17(1.08-1.27)",2571]
[null,"ADA",-0.082,0.051,-1.631,{"v":0.102851087,"d":"1.03E-01"},"0.92(0.83-1.02)",1577]
[null,"meta-analysis",0.039,{"v":0.12,"d":"0.120"},{"v":0.33,"d":"0.330"},{"v":0.741605382107871,"d":"7.42E-01"},"1.04(0.82-1.32)",4148]
["Anaerostipes","ADc12",-0.154,{"v":0.04,"d":"0.040"},{"v":-3.85,"d":"-3.850"},{"v":1.18097E-4,"d":"1.18E-04"},"0.86(0.79-0.93)",2571]
[null,"ADA",0.128,0.051,2.519,{"v":0.01175376,"d":"1.18E-02"},"1.14(1.03-1.26)",1577]
[null,"meta-analysis",-0.015,{"v":0.14,"d":"0.140"},-0.104,{"v":0.917119456467793,"d":"9.17E-01"},"0.99(0.75-1.30)",4148]
["Bacteroides","ADc12",0.188,{"v":0.04,"d":"0.040"},{"v":4.65,"d":"4.650"},{"v":3.32E-6,"d":"3.32E-06"},"1.21(1.12-1.31)",2571]
[null,"ADA",0.106,0.051,2.088,{"v":0.036790524,"d":"3.68E-02"},"1.11(1.01-1.23)",1577]
[null,"meta-analysis",0.152,0.041,3.756,{"v":0.000172471698412815,"d":"1.72E-04"},"1.16(1.08-1.26)",4148]
["Candidatus Soleaferrea*","ADc12",-0.166,{"v":0.04,"d":"0.040"},{"v":-4.14,"d":"-4.140"},{"v":3.48e-05,"d":"3.48E-05"},"0.85(0.78-0.92)",2571]
[null,"ADA",-0.077,0.051,-1.523,{"v":0.127832559,"d":"1.28E-01"},"0.93(0.84-1.02)",1577]
[null,"meta-analysis",-0.127,0.044,-2.873,{"v":0.00406545885574934,"d":"4.07E-03"},"0.88(0.81-0.96)",4148]
["Catenibacterium","ADc12",{"v":-0.16,"d":"-0.160"},0.041,-3.929,{"v":8.54e-05,"d":"8.54E-05"},"0.85(0.79-0.92)",2571]
[null,"ADA",0.156,0.051,3.074,{"v":2.113148E-3,"d":"2.11E-03"},"1.17(1.06-1.29)",1577]
[null,"meta-analysis",-0.003,0.158,-0.022,{"v":0.982523988771136,"d":"9.83E-01"},"1.00(0.73-1.36)",4148]
["Collinsella","ADc12",0.149,{"v":0.04,"d":"0.040"},3.749,{"v":1.77648E-4,"d":"1.78E-04"},"1.16(1.07-1.26)",2571]
[null,"ADA",0.209,0.051,4.087,{"v":4.36e-05,"d":"4.36E-05"},"1.23(1.12-1.36)",1577]
[null,"meta-analysis",0.172,0.031,5.471,{"v":4.47295837619427e-08,"d":"4.47E-08"},"1.19(1.12-1.26)",4148]
["Eisenbergiella","ADc12",-0.161,0.041,-3.899,{"v":9.64e-05,"d":"9.64E-05"},"0.85(0.78-0.92)",2571]
[null,"ADA",-0.142,0.051,{"v":-2.79,"d":"-2.790"},{"v":0.005277745,"d":"5.28E-03"},"0.87(0.79-0.96)",1577]
[null,"meta-analysis",-0.154,0.032,-4.806,{"v":1.53851088056863E-6,"d":"1.54E-06"},"0.86(0.81-0.91)",4148]
["Eubacterium Coprostanoligenes","meta-analysis",-0.031,0.137,-0.223,{"v":7.19e-05,"d":"7.19E-05"},"0.97(0.74-1.27)",2571]
[null,"ADc12",-0.166,0.042,{"v":-3.97,"d":"-3.970"},{"v":0.033585486,"d":"3.36E-02"},"0.85(0.78-0.92)",1577]
[null,"ADA",0.108,0.051,2.125,{"v":0.823389964499974,"d":"8.23E-01"},"1.11(1.01-1.23)",4148]
["Eubacterium Fissicatena","meta-analysis",-0.154,0.032,-4.826,{"v":3.0016E-4,"d":"3.00E-04"},"0.86(0.81-0.91)",2571]
[null,"ADc12",-0.147,0.041,-3.615,{"v":1.169827E-3,"d":"1.17E-03"},"0.86(0.80-0.93)",1577]
[null,"ADA",-0.165,0.051,-3.246,{"v":1.39039171992105e-06,"d":"1.39E-06"},"0.85(0.77-0.94)",4148]
["Eubacterium Nodatum","meta-analysis",-0.125,0.032,-3.909,{"v":0.00025198,"d":"2.52E-04"},"0.88(0.83-0.94)",2571]
[null,"ADc12",-0.149,0.041,{"v":-3.66,"d":"-3.660"},{"v":0.088200225,"d":"8.82E-02"},"0.86(0.79-0.93)",1577]
[null,"ADA",-0.086,0.051,-1.705,{"v":9.25135656970379e-05,"d":"9.25E-05"},"0.92(0.83-1.01)",4148]
["Gordonibacter","ADc12",{"v":-0.17,"d":"-0.170"},0.042,{"v":-4.03,"d":"-4.030"},{"v":5.57e-05,"d":"5.57E-05"},"0.84(0.78-0.92)",2571]
[null,"ADA",-0.108,0.051,-2.132,{"v":0.033044863,"d":"3.30E-02"},"0.90(0.81-0.99)",1577]
[null,"meta-analysis",-0.145,0.032,-4.458,{"v":8.26460301261135e-06,"d":"8.26E-06"},"0.87(0.81-0.92)",4148]
["Intestinibacter*","ADc12",-0.221,0.042,-5.324,{"v":1.01E-7,"d":"1.01E-07"},"0.80(0.74-0.87)",2571]
[null,"ADA",-0.085,0.051,-1.684,{"v":0.092158386,"d":"9.22E-02"},"0.92(0.83-1.01)",1577]
[null,"meta-analysis",-0.157,0.068,-2.302,{"v":0.0213089739415136,"d":"2.13E-02"},"0.85(0.75-0.98)",4148]
["LachnospiraceaeUCG008","ADc12",0.143,{"v":0.04,"d":"0.040"},{"v":3.59,"d":"3.590"},{"v":1.07804E-4,"d":"1.08E-04"},"1.15(1.07-1.25)",2571]
[null,"ADA",{"v":0.08,"d":"0.080"},0.051,1.592,{"v":0.156981283,"d":"1.57E-01"},"1.08(0.98-1.20)",1577]
[null,"meta-analysis",-0.046,0.116,-0.399,{"v":0.690101686868088,"d":"6.90E-01"},"0.95(0.76-1.20)",4148]
["Lachnospira","ADc12",{"v":-0.16,"d":"-0.160"},0.041,-3.872,{"v":0.000330113,"d":"3.30E-04"},"0.85(0.78-0.92)",2571]
[null,"ADA",0.071,{"v":0.05,"d":"0.050"},1.415,{"v":0.111467686,"d":"1.11E-01"},"1.07(0.97-1.19)",1577]
[null,"meta-analysis",0.119,0.031,3.794,{"v":1.48460158862489E-4,"d":"1.48E-04"},"1.13(1.06-1.20)",4148]
["Oscillibacter","ADc12",-0.144,{"v":0.04,"d":"0.040"},-3.609,{"v":3.07635E-4,"d":"3.08E-04"},"0.87(0.80-0.94)",2571]
[null,"ADA",{"v":0.09,"d":"0.090"},0.051,1.778,{"v":0.075465162,"d":"7.55E-02"},"1.09(0.99-1.21)",1577]
[null,"meta-analysis",-0.029,0.117,{"v":-0.25,"d":"-0.250"},{"v":0.802935605312188,"d":"8.03E-01"},"0.97(0.77-1.22)",4148]
["Prevotella9","ADc12",-0.152,{"v":0.04,"d":"0.040"},-3.779,{"v":1.57312E-4,"d":"1.57E-04"},"0.86(0.79-0.93)",2571]
[null,"ADA",-0.097,0.051,-1.921,{"v":0.054718097,"d":"5.47E-02"},"0.91(0.82-1.00)",1577]
[null,"meta-analysis",-0.131,0.031,-4.171,{"v":3.03310754330153e-05,"d":"3.03E-05"},"0.88(0.82-0.93)",4148]
["Roseburia*","ADc12",-0.176,{"v":0.04,"d":"0.040"},-4.352,{"v":1.35e-05,"d":"1.35E-05"},"0.84(0.77-0.91)",2571]
[null,"ADA",{"v":-0.09,"d":"-0.090"},0.051,-1.772,{"v":0.076356829,"d":"7.64E-02"},"0.91(0.83-1.01)",1577]
[null,"meta-analysis",-0.139,0.042,-3.268,{"v":1.08420589522747E-3,"d":"1.08E-03"},"0.87(0.80-0.95)",4148]
["Sutterella","ADc12",0.147,{"v":0.04,"d":"0.040"},3.659,{"v":0.000252899,"d":"2.53E-04"},"1.16(1.07-1.25)",2571]
[null,"ADA",-0.051,{"v":0.05,"d":"0.050"},-1.019,{"v":0.308137869,"d":"3.08E-01"},"0.95(0.86-1.05)",1577]
[null,"meta-analysis",{"v":0.05,"d":"0.050"},0.099,0.507,{"v":0.612158321571682,"d":"6.12E-01"},"1.05(0.87-1.28)",4148]
["Veillonella","ADc12",{"v":0.13,"d":"0.130"},{"v":0.04,"d":"0.040"},3.261,{"v":8.83e-05,"d":"8.83E-05"},"1.14(1.05-1.23)",2571]
[null,"ADA",0.161,0.051,3.164,{"v":0.0015583,"d":"1.56E-03"},"1.17(1.06-1.30)",1577]
[null,"meta-analysis",0.142,0.031,4.512,{"v":6.43074851314496e-06,"d":"6.43E-06"},"1.15(1.08-1.23)",4148]
[]
["Note: Logistic regression and meta-analysis were based on the PRSs from the “best-fit” model generated from PRSice-2. PRSs were normalized by z-score. Coeff.: coefficients; SE: standard error;  Odds-ratio at a level 95% confidence interval. Genera in bold are Ten genera identified to have genetically significant association with AD in the meta-analysis from discovery and replicate samples. *: indicades three genera that have the same direction in both discovery and replicate samples.  "]

{"sheet":"Table S2","index":1,"n_rows":64,"n_cols":7,"rows_kept":64,"merged":[[2,0,7,0],[8,0,13,0],[14,0,19,0],[20,0,25,0],[26,0,31,0],[32,0,37,0],[38,0,43,0],[44,0,49,0],[50,0,55,0],[56,0,61,0]]}
["Table S2. Multivariate logistic regression between the PRSs for the  ten significant gut microbiota genera and AD adjusted with sex, age, and APOE genotype in discovery sample."]
["Genera ","Variables","coeff.","SE","Z-value","P","OR(95%CI)"]
["Adlercreutzia","Intercept",{"v":-8.80463848780158,"d":"-8.805"},{"v":0.48936910345132,"d":"0.489"},{"v":-17.9918152284361,"d":"-17.992"},{"v":2.25837395390584e-72,"d":"2.26E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0604391547537102,"d":"0.060"},{"v":0.0966320537241753,"d":"0.097"},{"v":0.625456589448327,"d":"0.625"},{"v":0.531671431190686,"d":"5.32E-01"},"1.06(0.88-1.28)"]
[null,"Age",{"v":0.106753746439974,"d":"0.107"},{"v":6.01513432457749E-3,"d":"0.006"},{"v":17.7475249395154,"d":"17.748"},{"v":1.8011913480379e-70,"d":"1.80E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49806969666235,"d":"1.498"},{"v":0.0834220717420082,"d":"0.083"},{"v":17.9577138924971,"d":"17.958"},{"v":4.17658598333999e-72,"d":"4.18E-72"},"4.47(3.81-5.28)"]
[null,"rs7412_T",{"v":-0.626079432068445,"d":"-0.626"},{"v":0.161538863833988,"d":"0.162"},{"v":-3.87572016546968,"d":"-3.876"},{"v":1.06309805100958E-4,"d":"1.06E-04"},"0.53(0.39-0.73)"]
[null,"Best Score",{"v":-0.148141629972966,"d":"-0.148"},{"v":0.0470200138535033,"d":"0.047"},{"v":-3.15060796099549,"d":"-3.151"},{"v":0.00162931027686848,"d":"1.63E-03"},"0.86(0.79-0.94)"]
["Bacteroides","Intercept",{"v":-8.8126083191494,"d":"-8.813"},{"v":0.490120510387598,"d":"0.490"},{"v":-17.9804928224289,"d":"-17.980"},{"v":2.77019378733853E-72,"d":"2.77E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0688652247757379,"d":"0.069"},{"v":0.0967258691876456,"d":"0.097"},{"v":0.711962842558088,"d":"0.712"},{"v":0.476487785676979,"d":"4.76E-01"},"1.07(0.89-1.30)"]
[null,"Age",{"v":0.106586994870142,"d":"0.107"},{"v":0.0060208317568292,"d":"0.006"},{"v":17.7030349252401,"d":"17.703"},{"v":3.97307562167736e-70,"d":"3.97E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.5081511883079,"d":"1.508"},{"v":0.0836360258601142,"d":"0.084"},{"v":18.0323152947315,"d":"18.032"},{"v":1.08645530412262E-72,"d":"1.09E-72"},"4.52(3.84-5.33)"]
[null,"rs7412_T",{"v":-0.604846974545141,"d":"-0.605"},{"v":0.161249953948437,"d":"0.161"},{"v":-3.75099006067657,"d":"-3.751"},{"v":1.76137682753374E-4,"d":"1.76E-04"},"0.55(0.40-0.75)"]
[null,"Best Score",{"v":0.19952641100214,"d":"0.200"},{"v":0.0469258839762068,"d":"0.047"},{"v":4.25194783977448,"d":"4.252"},{"v":2.11919224866724e-05,"d":"2.12E-05"},"1.22(1.11-1.34)"]
["Collinsella","Intercept",{"v":-8.79668451281034,"d":"-8.797"},{"v":0.489080609427062,"d":"0.489"},{"v":-17.9861649455195,"d":"-17.986"},{"v":2.50077362272643e-72,"d":"2.50E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0631162075699417,"d":"0.063"},{"v":0.0965106483723414,"d":"0.097"},{"v":0.653981800292515,"d":"0.654"},{"v":0.513123531069408,"d":"5.13E-01"},"1.07(0.88-1.29)"]
[null,"Age",{"v":0.10664756313904,"d":"0.107"},{"v":0.00601026294885683,"d":"0.006"},{"v":17.7442424809924,"d":"17.744"},{"v":1.90957794580721e-70,"d":"1.91E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49153366867337,"d":"1.492"},{"v":0.0834529988700901,"d":"0.083"},{"v":17.8727390131925,"d":"17.873"},{"v":1.92315553037635e-71,"d":"1.92E-71"},"4.44(3.78-5.24)"]
[null,"rs7412_T",{"v":-0.631652608112172,"d":"-0.632"},{"v":0.162151999274971,"d":"0.162"},{"v":-3.89543521471506,"d":"-3.895"},{"v":9.8022560828846e-05,"d":"9.80E-05"},"0.53(0.38-0.73)"]
[null,"Best Score",{"v":0.100246751826673,"d":"0.100"},{"v":0.0459758425609459,"d":"0.046"},{"v":2.18042228793925,"d":"2.180"},{"v":0.0292261735168263,"d":"2.92E-02"},"1.11(1.01-1.21)"]
["Eisenbergiella","Intercept",{"v":-8.79542799464289,"d":"-8.795"},{"v":0.488836690386551,"d":"0.489"},{"v":-17.9925692314295,"d":"-17.993"},{"v":2.22785055925776E-72,"d":"2.23E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0690568026857285,"d":"0.069"},{"v":0.0966001849890481,"d":"0.097"},{"v":0.714872364825778,"d":"0.715"},{"v":0.474687914607886,"d":"4.75E-01"},"1.07(0.89-1.29)"]
[null,"Age",{"v":0.106495487571685,"d":"0.106"},{"v":0.00600706174014012,"d":"0.006"},{"v":17.7283823903567,"d":"17.728"},{"v":2.53215416373885e-70,"d":"2.53E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49117775132105,"d":"1.491"},{"v":0.0834300730782969,"d":"0.083"},{"v":17.873384216284,"d":"17.873"},{"v":1.90103735048081e-71,"d":"1.90E-71"},"4.44(3.78-5.24)"]
[null,"rs7412_T",{"v":-0.621678222432183,"d":"-0.622"},{"v":0.161358753413262,"d":"0.161"},{"v":-3.85277035972123,"d":"-3.853"},{"v":1.16788911428048E-4,"d":"1.17E-04"},"0.54(0.39-0.73)"]
[null,"Best Score",{"v":-0.124562206958105,"d":"-0.125"},{"v":0.0471602480436796,"d":"0.047"},{"v":-2.64125427929759,"d":"-2.641"},{"v":0.00825996997460757,"d":"8.26E-03"},"0.88(0.8-0.97)"]
["Eubacterium Fissicatenagroup","Intercept",{"v":-8.80876832419328,"d":"-8.809"},{"v":0.489422526099487,"d":"0.489"},{"v":-17.9982895237697,"d":"-17.998"},{"v":2.00929153111921e-72,"d":"2.01E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0678289064799655,"d":"0.068"},{"v":0.096538068230868,"d":"0.097"},{"v":0.702613049162686,"d":"0.703"},{"v":0.482296928087431,"d":"4.82E-01"},"1.07(0.89-1.29)"]
[null,"Age",{"v":0.10668489185428,"d":"0.107"},{"v":0.00601252181394418,"d":"0.006"},{"v":17.7437845808488,"d":"17.744"},{"v":1.92520581270953e-70,"d":"1.93E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49317167061192,"d":"1.493"},{"v":0.083463400090936,"d":"0.083"},{"v":17.8901371018323,"d":"17.890"},{"v":1.40761603990678E-71,"d":"1.41E-71"},"4.45(3.79-5.25)"]
[null,"rs7412_T",{"v":-0.622518048200879,"d":"-0.623"},{"v":0.161297570647969,"d":"0.161"},{"v":-3.85943846333261,"d":"-3.859"},{"v":1.13647869689954E-4,"d":"1.14E-04"},"0.54(0.39-0.73)"]
[null,"Best Score",{"v":-0.110986543289908,"d":"-0.111"},{"v":0.0468179968839492,"d":"0.047"},{"v":-2.37059572550739,"d":"-2.371"},{"v":0.0177594444473614,"d":"1.78E-02"},"0.89(0.82-0.98)"]
["Eubacterium Nodatumgroup","Intercept",{"v":-8.80949842512194,"d":"-8.809"},{"v":0.489525789153718,"d":"0.490"},{"v":-17.995984318521,"d":"-17.996"},{"v":2.09467118901475E-72,"d":"2.09E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0704702559769223,"d":"0.070"},{"v":0.0965853890511726,"d":"0.097"},{"v":0.729616111393266,"d":"0.730"},{"v":0.465624871239865,"d":"4.66E-01"},"1.07(0.89-1.3)"]
[null,"Age",{"v":0.106613299040996,"d":"0.107"},{"v":0.00601319394141291,"d":"0.006"},{"v":17.7298953068434,"d":"17.730"},{"v":2.4649286987889e-70,"d":"2.46E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49437180294616,"d":"1.494"},{"v":0.0834095301539468,"d":"0.083"},{"v":17.9160798554797,"d":"17.916"},{"v":8.83381102717993E-72,"d":"8.83E-72"},"4.46(3.79-5.26)"]
[null,"rs7412_T",{"v":-0.61623182931189,"d":"-0.616"},{"v":0.161423025010818,"d":"0.161"},{"v":-3.81749647716361,"d":"-3.817"},{"v":1.3481271158202E-4,"d":"1.35E-04"},"0.54(0.39-0.74)"]
[null,"Best Score",{"v":-0.110946354450671,"d":"-0.111"},{"v":0.0467864293624358,"d":"0.047"},{"v":-2.37133621784245,"d":"-2.371"},{"v":0.0177238999906,"d":"1.77E-02"},"0.89(0.82-0.98)"]
["Gordonibacter","Intercept",{"v":-8.8067414400787,"d":"-8.807"},{"v":0.489584311390095,"d":"0.490"},{"v":-17.9882018994305,"d":"-17.988"},{"v":2.41053451699457e-72,"d":"2.41E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0671723701160221,"d":"0.067"},{"v":0.096613469824171,"d":"0.097"},{"v":0.695269202506344,"d":"0.695"},{"v":0.486886610921027,"d":"4.87E-01"},"1.07(0.88-1.29)"]
[null,"Age",{"v":0.106672491054105,"d":"0.107"},{"v":0.00601491073390051,"d":"0.006"},{"v":17.7346756707278,"d":"17.735"},{"v":2.26398878626136e-70,"d":"2.26E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49218605290065,"d":"1.492"},{"v":0.0834724852217023,"d":"0.083"},{"v":17.8763822466459,"d":"17.876"},{"v":1.80154310682443E-71,"d":"1.80E-71"},"4.45(3.78-5.25)"]
[null,"rs7412_T",{"v":-0.620549602931642,"d":"-0.621"},{"v":0.161325375752592,"d":"0.161"},{"v":-3.84657156406266,"d":"-3.847"},{"v":0.000119782155639437,"d":"1.20E-04"},"0.54(0.39-0.73)"]
[null,"Best Score",{"v":-0.13695845923354,"d":"-0.137"},{"v":0.0476563777520283,"d":"0.048"},{"v":-2.8738747192701,"d":"-2.874"},{"v":0.00405469765725147,"d":"4.05E-03"},"0.87(0.79-0.96)"]
["Lachnospira","Intercept",{"v":-8.79311940640592,"d":"-8.793"},{"v":0.489543453164346,"d":"0.490"},{"v":-17.9618772339173,"d":"-17.962"},{"v":3.87478819792424e-72,"d":"3.87E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0585910831150361,"d":"0.059"},{"v":0.0965515559942909,"d":"0.097"},{"v":0.60683727477681,"d":"0.607"},{"v":0.543958908396619,"d":"5.44E-01"},"1.06(0.88-1.28)"]
[null,"Age",{"v":0.106605767705254,"d":"0.107"},{"v":0.00601226703537248,"d":"0.006"},{"v":17.7313760480118,"d":"17.731"},{"v":2.40085616544034e-70,"d":"2.40E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49886525711572,"d":"1.499"},{"v":0.0834043132658962,"d":"0.083"},{"v":17.97107605619,"d":"17.971"},{"v":3.28284919450495e-72,"d":"3.28E-72"},"4.48(3.81-5.28)"]
[null,"rs7412_T",{"v":-0.612570295109142,"d":"-0.613"},{"v":0.161476665137581,"d":"0.161"},{"v":-3.79355304735345,"d":"-3.794"},{"v":0.000148506886303837,"d":"1.49E-04"},"0.54(0.39-0.74)"]
[null,"Best Score",{"v":0.126750708266321,"d":"0.127"},{"v":0.0459907745726442,"d":"0.046"},{"v":2.75600290371526,"d":"2.756"},{"v":0.00585124775350418,"d":"5.85E-03"},"1.14(1.04-1.24)"]
["Prevotella9","Intercept",{"v":-8.78175575080207,"d":"-8.782"},{"v":0.488805262827942,"d":"0.489"},{"v":-17.9657553194005,"d":"-17.966"},{"v":3.61326292747558e-72,"d":"3.61E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0678770027244335,"d":"0.068"},{"v":0.0965500934450784,"d":"0.097"},{"v":0.703023687522837,"d":"0.703"},{"v":0.48204098765305,"d":"4.82E-01"},"1.07(0.89-1.29)"]
[null,"Age",{"v":0.106263978605285,"d":"0.106"},{"v":0.00600852012702273,"d":"0.006"},{"v":17.6855492465396,"d":"17.686"},{"v":5.41904289834465e-70,"d":"5.42E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.49729958153014,"d":"1.497"},{"v":0.0833382522423384,"d":"0.083"},{"v":17.9665344693834,"d":"17.967"},{"v":3.56288210581256E-72,"d":"3.56E-72"},"4.47(3.80-5.27)"]
[null,"rs7412_T",{"v":-0.612154257473228,"d":"-0.612"},{"v":0.161151099743367,"d":"0.161"},{"v":-3.79863530840363,"d":"-3.799"},{"v":0.000145494992335266,"d":"1.45E-04"},"0.54(0.39-0.74)"]
[null,"Best Score",{"v":-0.124247158683929,"d":"-0.124"},{"v":0.0467469990651031,"d":"0.047"},{"v":-2.65786384513995,"d":"-2.658"},{"v":0.00786376555135167,"d":"7.86E-03"},"0.88(0.81-0.97)"]
["Veillonella","Intercept",{"v":-8.81610619806636,"d":"-8.816"},{"v":0.488873229193476,"d":"0.489"},{"v":-18.0335221313117,"d":"-18.034"},{"v":1.06299572505236E-72,"d":"1.06E-72"},"0.00(0.00-0.00)"]
[null,"Sex",{"v":0.0694168882761713,"d":"0.069"},{"v":0.0965695234966741,"d":"0.097"},{"v":0.718828112251813,"d":"0.719"},{"v":0.472246834120266,"d":"4.72E-01"},"1.07(0.89-1.30)"]
[null,"Age",{"v":0.106750760239034,"d":"0.107"},{"v":0.00600848450021669,"d":"0.006"},{"v":17.7666698208482,"d":"17.767"},{"v":1.28071608459548e-70,"d":"1.28E-70"},"1.11(1.10-1.13)"]
[null,"rs429358_C",{"v":1.495915111144,"d":"1.496"},{"v":0.0834461337784982,"d":"0.083"},{"v":17.9267156356794,"d":"17.927"},{"v":7.29645522947206e-72,"d":"7.30E-72"},"4.46(3.80-5.27)"]
[null,"rs7412_T",{"v":-0.623405050271254,"d":"-0.623"},{"v":0.161650130726925,"d":"0.162"},{"v":-3.85650817272996,"d":"-3.857"},{"v":1.15018254292525E-4,"d":"1.15E-04"},"0.54(0.39-0.73)"]
[null,"Best Score",{"v":0.116068845782448,"d":"0.116"},{"v":0.0465333000608762,"d":"0.047"},{"v":2.49431795360748,"d":"2.494"},{"v":0.0126199443057917,"d":"1.26E-02"},"1.12(1.03-1.23)"]
[]
["Note: Coeff.: coefficients; SE: standard error; OR (95% CI): Odds-ratio at a level 95% confidence interval. P (<0.05 ) in bold was considered as significant. All the ten significant genera remain significant after adjusted with sex, age, and APOE genotype. "]

{"sheet":"Table S3","index":2,"n_rows":34,"n_cols":7,"rows_kept":34,"merged":[[2,0,4,0],[5,0,7,0],[8,0,10,0],[11,0,13,0],[14,0,16,0],[17,0,19,0],[20,0,22,0],[23,0,25,0],[26,0,28,0],[29,0,31,0],[44,0,46,0],[47,0,49,0],[56,0,58,0]]}
["Table S3. Linear regression and meta-analysis between the PRSs for the ten significant gut microbiota and APOE rs429358 risk allele C adjusted with sex and age."]
["Trait","Samples","Coeff.","SE","z-value","p","OR (95%CI)"]
["Adlercreutzia","ADc12",{"v":-0.052020939,"d":"-0.052"},{"v":0.031201859,"d":"0.031"},{"v":-1.66723845,"d":"-1.667"},{"v":0.095589029,"d":"0.096"},"0.95(0.89-1.01)"]
[null,"GenADA",{"v":-0.092007754,"d":"-0.092"},{"v":0.040551647,"d":"0.041"},{"v":-2.268902993,"d":"-2.269"},{"v":0.023409271,"d":"0.023"},"0.91(0.84-0.99)"]
[null,"meta-analysis",{"v":-0.066890886,"d":"-0.067"},{"v":0.0247289,"d":"0.025"},{"v":-2.704968091,"d":"-2.705"},{"v":0.006831095,"d":"6.83E-03"},"0.94(0.89-0.98)"]
["Bacteroides","ADc12",{"v":0.020936197,"d":"0.021"},{"v":0.031203521,"d":"0.031"},{"v":0.670956231,"d":"0.671"},{"v":0.502308801,"d":"0.502"},"1.02(0.96-1.09)"]
[null,"GenADA",{"v":0.014838166,"d":"0.015"},{"v":0.040590188,"d":"0.041"},{"v":0.36556042,"d":"0.366"},{"v":0.714742296,"d":"0.715"},"1.01(0.94-1.10)"]
[null,"meta-analysis",{"v":0.018671068,"d":"0.019"},{"v":0.024738461,"d":"0.025"},{"v":0.754738471,"d":"0.755"},{"v":0.450405918,"d":"0.450"},"1.02(0.97-1.07)"]
["Collinsella","ADc12",{"v":0.138740069,"d":"0.139"},{"v":0.03109332,"d":"0.031"},{"v":4.462053817,"d":"4.462"},{"v":8.47e-06,"d":"8.47E-06"},"1.15(1.08-1.22)"]
[null,"GenADA",{"v":0.120840047,"d":"0.121"},{"v":0.040501728,"d":"0.041"},{"v":2.983577596,"d":"2.984"},{"v":0.002892916,"d":"0.003"},"1.13(1.04-1.22)"]
[null,"meta-analysis",{"v":0.132102394,"d":"0.132"},{"v":0.024663503,"d":"0.025"},{"v":5.356189373,"d":"5.356"},{"v":8.5e-08,"d":"8.50E-08"},"1.14(1.09-1.20)"]
["Eisenbergiella","ADc12",{"v":-0.106010165,"d":"-0.106"},{"v":0.031139046,"d":"0.031"},{"v":-3.404412743,"d":"-3.404"},{"v":0.000673251,"d":"0.001"},"0.90(0.85-0.96)"]
[null,"GenADA",{"v":0.007099075,"d":"0.007"},{"v":0.040613367,"d":"0.041"},{"v":0.174796517,"d":"0.175"},{"v":0.861262034,"d":"0.861"},"1.01(0.93-1.09)"]
[null,"meta-analysis",{"v":-0.052460629,"d":"-0.052"},{"v":0.056474725,"d":"0.056"},{"v":-0.928922256,"d":"-0.929"},{"v":0.352929378,"d":"0.353"},"0.95(0.85-1.06)"]
["Eubacterium fissicatena","ADc12",{"v":-0.111598352,"d":"-0.112"},{"v":0.031139345,"d":"0.031"},{"v":-3.583837455,"d":"-3.584"},{"v":0.00034489,"d":"3.45E-04"},"0.89(0.84-0.95)"]
[null,"GenADA",{"v":-2.254177E-3,"d":"-0.002"},{"v":0.040572446,"d":"0.041"},{"v":-0.055559319,"d":"-0.056"},{"v":0.955699933,"d":"0.956"},"1.00(0.92-1.08)"]
[null,"meta-analysis",{"v":-0.060019546,"d":"-0.060"},{"v":0.05458451,"d":"0.055"},{"v":-1.099571037,"d":"-1.100"},{"v":0.271519067,"d":"0.272"},"0.94(0.85-1.05)"]
["Eubacterium nodatum","ADc12",{"v":-0.098692961,"d":"-0.099"},{"v":0.031144909,"d":"0.031"},{"v":-3.168831275,"d":"-3.169"},{"v":1.548542E-3,"d":"0.002"},"0.91(0.85-0.96)"]
[null,"GenADA",{"v":-0.048476652,"d":"-0.048"},{"v":0.040572314,"d":"0.041"},{"v":-1.194820971,"d":"-1.195"},{"v":0.232337218,"d":"0.232"},"0.95(0.88-1.03)"]
[null,"meta-analysis",{"v":-0.080073737,"d":"-0.080"},{"v":0.024705189,"d":"0.025"},{"v":-3.241170796,"d":"-3.241"},{"v":0.001190398,"d":"1.19E-03"},"0.92(0.88-0.97)"]
["Gordonibacter","ADc12",{"v":-0.108709049,"d":"-0.109"},{"v":0.031144639,"d":"0.031"},{"v":-3.490457806,"d":"-3.490"},{"v":0.000490327,"d":"0.000"},"0.90(0.84-0.95)"]
[null,"GenADA",{"v":-0.014631323,"d":"-0.015"},{"v":0.04060438,"d":"0.041"},{"v":-0.360338547,"d":"-0.360"},{"v":0.718642385,"d":"0.719"},"0.99(0.91-1.07)"]
[null,"meta-analysis",{"v":-0.065277454,"d":"-0.065"},{"v":0.046900344,"d":"0.047"},{"v":-1.391833156,"d":"-1.392"},{"v":0.163972927,"d":"0.164"},"0.94(0.85-1.03)"]
["Lachnospira","ADc12",{"v":0.049721895,"d":"0.050"},{"v":0.031181441,"d":"0.031"},{"v":1.594599028,"d":"1.595"},{"v":0.110925082,"d":"0.111"},"1.05(0.99-1.12)"]
[null,"GenADA",{"v":0.04835374,"d":"0.048"},{"v":0.040553246,"d":"0.041"},{"v":1.192351924,"d":"1.192"},{"v":0.233303236,"d":"0.233"},"1.05(0.97-1.14)"]
[null,"meta-analysis",{"v":0.049213561,"d":"0.049"},{"v":0.024719094,"d":"0.025"},{"v":1.990912795,"d":"1.991"},{"v":0.046490475,"d":"0.046"},"1.05(1.00-1.10)"]
["Prevotella9","ADc12",{"v":-0.048290796,"d":"-0.048"},{"v":0.031179307,"d":"0.031"},{"v":-1.548809116,"d":"-1.549"},{"v":0.121550931,"d":"0.122"},"0.95(0.90-1.01)"]
[null,"GenADA",{"v":-0.071596328,"d":"-0.072"},{"v":0.040559553,"d":"0.041"},{"v":-1.765214947,"d":"-1.765"},{"v":0.077721773,"d":"0.078"},"0.93(0.86-1.01)"]
[null,"meta-analysis",{"v":-0.056947461,"d":"-0.057"},{"v":0.024719459,"d":"0.025"},{"v":-2.303750302,"d":"-2.304"},{"v":0.021236664,"d":"0.021"},"0.94(0.90-0.99)"]
["Veillonella","ADc12",{"v":0.091723351,"d":"0.092"},{"v":0.031164404,"d":"0.031"},{"v":2.943208944,"d":"2.943"},{"v":0.003277432,"d":"0.003"},"1.10(1.03-1.17)"]
[null,"GenADA",{"v":-0.024559022,"d":"-0.025"},{"v":0.040610543,"d":"0.041"},{"v":-0.604744973,"d":"-0.605"},{"v":0.545435738,"d":"0.545"},"0.98(0.90-1.06)"]
[null,"meta-analysis",{"v":0.036497465,"d":"0.036"},{"v":0.058068052,"d":"0.058"},{"v":0.628529185,"d":"0.629"},{"v":0.529657334,"d":"0.530"},"1.04(0.93-1.16)"]
[]
["Note: Genera in bold are five genera identified to have genetically significant correlation with AD in the meta-analysis (p< 0.05). Collinsella was the only genus that showed significant correlation in both samples"]