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["Supplemental Tables 1-5"]
["Expectation and acceptance of clinical decision support systems: A survey study among nephrologist end-users"]
[]
[null,"Fruzsina Kotsis1,2*, Helena Bächle1*, Michael Altenbuchinger3, Jürgen Dönitz3,4, Yacoub Abelard Njipouombe Nsangou4, Heike Meiselbach5, Robin Kosch3, Sabine Salloch6, Tanja Bratan7, Helena U. Zacharias8, Ulla T. Schultheiss1,2"]
[]
[null,"1Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany "]
[null,"2Department of Medicine IV – Nephrology and Primary Care, Faculty of Medicine and Medical Center - University of Freiburg, Germany"]
[null,"3Department of Medical Bioinformatics, University Medical Center Göttingen, Göttingen, Germany"]
[null,"4Institute of Computational Biology, Helmholtz Zentrum München, Germany "]
[null,"5Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany"]
[null,"6Institute for Ethics, History and Philosophy of Medicine, Hanover Medical School, Hanover, Germany"]
[null,"7https://www.isi.fraunhofer.de/, Karlsruhe, Germany"]
[null,"8Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Hannover, Germany."]
[]
["Content of Supplemental Tables"]
[]
["Tab","Title"]
["Content","Content of additional file 1"]
["Supplemental Table 1","CKDNapp survey questionnaire questions and answer possibilities."]
["Supplemental Table 2","Complete numbers and percentages to questions on experiences with clinical decision support software of module 1."]
["Supplemental Table 3","Complete numbers and percentages to questions on expectations of a clinical decision support software in general of module 2."]
["Supplemental Table 4","Complete numbers and percentages to questions on prediction algorithms of module 3."]
["Supplemental Table 5","Complete overview of questions on ethical aspects of CDSS from module 4."]

{"sheet":"Supplemental Table 1","index":1,"n_rows":51,"n_cols":3,"rows_kept":51,"flags":["formulas_cached_only"]}
["Supplemental Table 1: CKDNapp survey questionnaire questions and answer possibilities."]
[null,"Demographics","possible answers"]
["D.1","To which age group do you belong?","< 40 | 40-50| 51-60|> 60|not specified"]
["D.2","What is your gender","0 male|1 female |2 diverse|3 not specified"]
["D.3","For how many years have you been a consultant in the field of nephrology?"]
["D.4","For how many years have you been practicing as a nephrologist in a out-patient practice?"]
["D.5","For how many years have you been practicing in out-patient care?"]
["D.6","How many patients do you see per day?"]
["D.7","How many patients with CKD do you see per day?"]
["D.8","Are you using the German wide medication plan?","1 yes|2 no|3 not for all patients|4 not specified"]
["D.9","Are you using it's QR function?","1 yes|2 no|3 not specified"]
[null,"Module 1"]
["M1.1","How often are you using CDSS in your daily routine?","1 daily|2 several times a week|3 several times a month|4 rarely|5 never|6 not specified"]
["M1.2","What are your reasons for this?","1 not needed|2 no good systems are available|3 I do not know enough about it|4 CDSS are impratical in everyday life|5 CDSS do not contain any advantages|6 CDSS give out not comprehensible advice|7 other reasons|8 not specified"]
[null,"Please rate the following questions:"]
["M1.3","I feel confident using CDSS."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.4","I am knowledgable in the way CDSS can be applied in patient care."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.5","I find that a CDSS with personalized information and prognosis about CKD in general is helpful."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.6","A personalized CDSS could be helpful in treating my patients with CKD."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.7","A CDSS could improve the quality of patient care."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.8","A CDSS could improve the efficiency of my work."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.9","Using a CDSS would fit into my daily routine."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M1.10","Would you be willing to try out an available CKD patient CDSS?"," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
[null,"Module 2"]
[null,"An opitmal CDSS should…"]
["M2.1","…incorporate all newest guidelines for CKD and it's comorbidites, which should be easily accesible. "," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M2.2","…be able to provide fast and easy access to other important secondary information for patient care, if needed."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M2.3","…contain a clear review of all patient data from any before visits (patient history, lab values, diagnoses,…)."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M2.4","…not change the way I am organizing my workday."," 1: not applicable|2: mostly not applicable|3: applies partially 4: mostly applicable|5: completely correct|6: not specified"]
["M2.5","Which device would you preferrably use when applying a CDSS?","1 cell phone|2 tablet|3 desktop computer with internetbrowser|4 other|5 no preference|6 not specified"]
[null,"Module 3"]
[null,"Please rate the following statements from 1: unimportant to 5: very important"]
[null,"Rate the importance of the following indivdualized adverse event prediction planned as features for CKDNapp."]
["M3.1","acute kidney injury","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
["M3.2","progression of CKD","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
["M3.3","stroke","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
["M3.4","worsening of PAOD","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
["M3.5","CKDNapp should contain a possibility to predict patient's risk of mortality.","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
["M3.6","CKDNapp shoud provide easy access to latest guidelines.","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
[null,"CKDNapp will contain an in-silico modification mode where physicians can change single factors to see how prediction algorithms might change for patiens.sind außerdem Simulationen für den Krankheitsverlauf einzelner Patienten geplant, die zeigen sollen, wie die chronische Nierenerkrankung verlaufen könnte, wenn sich bestimmte Faktoren ändern."]
["M3.7","CKDNapp should contain this in-silico mode feature.","1: unimportant|2: mostly not important|3: neutral|4: mostly important|5: very important | 6: not specified"]
["M3.8","Would you be willing to test a first version of a CDSS?","1 yes|2 no|3 maybe|4 not specified"]
[null,"Module 4"]
[null,"Please rate the following statements from 1: not true to 5: true."]
["M4.1","Certain parts of a physicians work will be taken over by CDSS in the future."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]
["M4.2","CDSS are most helpful for inexperienced doctors."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]
["M4.3","The application of CDSS will lead to a reduction of clinical abilities of physicians in the future."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]
["M4.4","CDSS will lead to a shift for doctors towards a more patient centered medicine in the future."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]
["M4.5","Missing background information/transparency of the advice given by CDSS is a problem."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]
["M4.6","CDSS will lead to a reduction of trust patients will put into their treating physicians and their abilities."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]
["M4.7","The application of CDSS may lead to discrimination of some patient groups."," 1: not true|2: mostly not true|3: partially true 4: mostly true|5: completely correct|6: not specified"]

{"sheet":"Supplemental Table 2","index":2,"n_rows":19,"n_cols":11,"rows_kept":19,"flags":["formulas_cached_only"]}
["Supplemental Table 2: Complete numbers and percentages to questions on experiences with clinical decision support software of module 1."]
[]
[]
[null,"daily","weekly","monthly","rarely","never","N answers","N missing","N not specified"]
["M1.1 how often are you using CDSS in your daily routing","3, 6.3%","5, 10.4%","1, 2.1%","16, 33.3%","23, 47.9%","48",6,0]
[]
[null,"not needed","no good systems","no knowledge","impractical","no advantages","no comprehensible advice","other reasons","N answers","N missing","N not specified"]
["M1.2 What are reasons for not using CDSS","9, 20.5%","7, 15.9%","19, 43.2%","4, 9.1%","4, 9.1%","1, 2.3%","9, 20.5%",44,10,"2, 4.5%"]
[]
[null,1,2,3,4,5,"sum 1+2 (%)",null,null,6]
["answer possibilities","not applicable","mostly not applicable","applies partially","mostly applicable","completely correct","mostly not and not applicable ","N answers","N missing","N not specified"]
["M1.3 I feel confident using CDSS.","18, 38.3%","10, 21.3%","1, 2.1%","11, 23.4%","3, 6.4%",59.6,47,7,4]
["M1.4 I am knowledgable in the way CDSS can be applied in patient care.","16, 34.8%","10, 21.7%","9, 19.6%","8, 17.4%","1, 2.2%",56.5,46,8,2]
["M1.5 I find that a CDSS with personalized information and prognosis about CKD in general is helpful.","1, 2.1%","3, 6.4%","3, 6.4%","18, 38.3%","20, 42.6%",80.9,47,7,2]
["M1.6 A personalized CDSS could be helpful in treating my patients with CKD.","1, 2.1%","2, 4.3%","9, 19.2%","16, 34.0%","17, 36.2",70.2,47,7,2]
["M1.7 A CDSS could improve the quality of patient care.","2, 4.4%","0, 0.0%","10, 21.7%","15, 32.6%","18, 39.1%",71.7,46,8,1]
["M1.8 A CDSS could improve the efficiency of my work.","1, 2.2%","4, 8.7%","10, 21.7%","20, 43.5%","9, 19.6%",63.1,46,8,2]
["M1.9 Using a CDSS would fit into my daily routine.","2, 4.3%","4, 8.5%","15, 31.9%","13, 27.7%","8, 17.0%",44.7,47,7,5]
["M1.10 Would you be willing to try out an available CKD patient CDSS?","1, 2.1%","1, 2.1%","8, 17.4%","14, 30.4%","20, 43.5%",73.9,46,8,2]

{"sheet":"Supplemental Table 3","index":3,"n_rows":16,"n_cols":11,"rows_kept":16,"flags":["formulas_cached_only"]}
["Supplemental Table 3: Complete numbers and percentages to questions on expectations of a clinical decision support software in general of module 2."]
[]
["Answer possibilities for M2.1 to M2.4: 1 not applicable, 2 mostly not applicable, 3 applies partially, 4 mostly applicable, 5 completely correct, 6 not specified"]
[null,1,2,3,4,5,"sum 1+2 (%)","sum 4+5 (%)",null,null,6]
["An optimal CDSS should…","not applicable","mostly not applicable","applies partially","mostly applicable","completely correct","not or mostly not applicable","mostly or completely correct","N answers","N missing","N not specified"]
["M2.1 …incorporate all newest guidelines for CKD and it's comorbidites, which should be easily accesible. ","0, 0.0%","0, 0.0%","2, 4.4%","7, 15.6%","36, 80.0%",{"v":0,"d":"0.0"},95.6,45,9,0]
["M2.2 …be able to provide fast and easy access to other important secondary information for patient care, if needed.","0, 0.0%","0, 0.0%","1, 2.2%","7, 15.6%","37, 82.2%",{"v":0,"d":"0.0"},97.8,45,9,0]
["M2.3 …contain a clear review of all patient data from any before visits (patient history, lab values, diagnoses,…).","0, 0.0%","6, 13.3%","5, 11.1%","8, 17.8%","26, 57.8%",13.3,75.6,45,9,0]
["M2.4 …not change the way I am organizing my workday.","1, 2.2%","4, 8.9%","23, 51.1%","12, 26.7%","5, 11.1%",11.1,37.8,45,9,0]
[]
[]
[]
[]
["Answer possibilities for M2.5: 1 cell phone, 2 tablet, 3 desktop computer wiht internetbrowser, 4 other, 5 no preference, 6 not specified"]
[null,"cell phone","tablet","computer ","other","no preference","N answers","N missing","N not specified"]
["M2.5 Which device would you preferrably use when applying a CDSS?","7, 15.6%","3, 6.7%","30, 66.7%","4, 8.9%","1, 2.2%",45,9,0]

{"sheet":"Supplemental Table 4","index":4,"n_rows":18,"n_cols":10,"rows_kept":18,"flags":["formulas_cached_only"]}
["Supplemental Table 4: Complete numbers and percentages to questions on prediction algorithms of module 3."]
[]
[null,1,2,3,4,5,"sum 4+5 (%)",null,null,6]
["answer possibilities","unimportant","mostly not important","neutral","mostly important","very important","mostly or completely correct","N answers","N missing","N not specified"]
["M3.1 AKI event","0, 0.0%","0, 0.0%","2, 4.4%","15, 33.3%","28, 62.2%",95.5,45,9,0]
["M3.2 CKD progression","0, 0.0%","0, 0.0%","1, 2.2%","9, 20.0%","35, 77.8%",97.8,45,9,0]
["M3.3 stroke event","0, 0.0%","1, 2.3%","8, 18.2%","19, 43.2%","16, 36.4%",79.6,44,10,0]
["M3.4 PAOD event","0, 0.0%","3, 6.7%","6, 13.3%","23, 51.1%","13, 28.9%",{"v":80,"d":"80.0"},45,9,0]
["M3.5 mortality","0, 0.0%","2, 4.6%","6, 13.6%","21, 47.7%","14, 31.8%",79.5,44,10,1]
["M3.6 access to guidelines","0, 0.0%","1, 2.2%","2, 4.4%","8, 17.8%","34, 75.6%",{"v":93.34,"d":"93.3"},45,9,0]
["M3.7 in-silico mode","0, 0.0%","0, 0.0%","1, 2.3%","15, 34.1%","28, 63.6%",{"v":97.73,"d":"97.7"},44,10,0]
[]
[]
[]
["M3.8 Would you be willing to test a first version of a CDSS? "]
[null,1,2,3,null,null,4]
["answer possibilites","yes","no","maybe","N answers","N missing","N not specified"]
["M3.8  test CDSS","38, 84.4%","0, 0.0%","7, 15.6%",45,9,0]

{"sheet":"Supplemental Table 5","index":5,"n_rows":76,"n_cols":5,"rows_kept":76,"flags":["formulas_cached_only"]}
["Supplemental Table 5: Complete overview of questions on ethical aspects of CDSS from module 4."]
[]
[]
["Answer possibilites for M4.1 to M4.7:  1 not true, 2 mostly not true, 3 partially true, 4 mostly true, 5 completely correct, 6 not specified"]
[]
["M4.1","Certain parts of a physicians work will be taken over by CDSS in the future."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,1,"2.22","2.22"]
[2,7,"15.56","17.78"]
[3,15,"33.33","51.11"]
[4,15,"33.33","84.44"]
[5,7,"15.56","100.00"]
["Total",45,"100.00",null,9]
[]
[]
["M4.2","CDSS are most helpful for inexperienced doctors."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,2,"4.44","4.44"]
[2,11,"24.44","28.89"]
[3,13,"28.89","57.78"]
[4,13,"28.89","86.67"]
[5,5,"11.11","97.78"]
[6,1,"2.22","100.00"]
["Total",45,"100.00",null,9]
[]
[]
["M4.3","The application of CDSS will lead to a reduction of clinical abilities of physicians in the future."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,9,"20.00","20.00"]
[2,21,"46.67","66.67"]
[3,6,"13.33","80.00"]
[4,8,"17.78","97.78"]
[5,1,"2.22","100.00"]
["Total",45,"100.00",null,9]
[]
[]
["M4.4","CDSS will lead to a shift for doctors towards a more patient centered medicine in the future."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,4,"9.30","9.30"]
[2,12,"27.91","37.21"]
[3,13,"30.23","67.44"]
[4,11,"25.58","93.02"]
[5,3,"6.98","100.00"]
["Total",43,"100.00",null,11]
[]
[]
["M4.5","Missing background information/transparency of the advice given by CDSS is a problem."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,3,"6.98","6.98"]
[2,12,"27.91","34.88"]
[3,10,"23.26","58.14"]
[4,9,"20.93","79.07"]
[5,2,"4.65","83.72"]
[6,7,"16.28","100.00"]
["Total",43,"100.00",null,11]
[]
[]
["M4.6","CDSS will lead to a reduction of trust patients will put into their treating physicians and their abilities."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,12,"26.67","26.67"]
[2,24,"53.33","80.00"]
[3,6,"13.33","93.33"]
[4,2,"4.44","97.78"]
[6,1,"2.22","100.00"]
["Total",45,"100.00",null,"9"]
[]
[]
["M4.7","The application of CDSS may lead to discrimination of some patient groups."]
["Answers","Frequency","Percent","Cumulative","N missing"]
[1,7,"15.56","15.56"]
[2,24,"53.33","68.89"]
[3,5,"11.11","80.00"]
[4,4,"8.89","88.89"]
[5,1,"2.22","91.11"]
[6,4,"8.89","100.00"]
["Total",45,"100.00",null,9]