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["Supplementary File 2: Linear Mixed Effects Models - Complete statistical findings"]
["Figure","Treatment group",{"$nulls":4},"Confidence intervals","P-value","Overall P-value"]
["Fig1b",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value","Overall P-value"]
[null,null,"Intercept",44.254,2.417,{"v":40.021019,"d":"40.021"},{"v":48.487394,"d":"48.487"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",23.392,3.814,{"v":16.711868,"d":"16.712"},{"v":30.071377,"d":"30.071"},{"v":0.00176,"d":"0.0018"},{"v":0.002259,"d":"0.0023"}]
[null,null,"GenotypeTDP43-K145R vs TDP43-wt",-2.809,3.412,{"v":-8.785687,"d":"-8.786"},{"v":3.167447,"d":"3.167"},{"v":0.44841,"d":"0.4484"}]
[]
[]
[]
["Fig1c","Treatment group: NaAsO2",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value","Overall P-value"]
[null,null,"Intercept",2.945,{"v":0.4324,"d":"0.432"},{"v":2.1720927,"d":"2.172"},{"v":3.7178775,"d":"3.718"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":3.6741,"d":"3.674"},{"v":0.6116,"d":"0.612"},{"v":2.5810456,"d":"2.581"},{"v":4.7671154,"d":"4.767"},{"v":0.000958,"d":"0.0010"},{"v":0.0009585,"d":"0.0010"}]
[null,null,"GenotypeTDP43-K145R vs TDP43-wt",{"v":-0.4571,"d":"-0.457"},{"v":0.6116,"d":"0.612"},{"v":-1.5501717,"d":"-1.550"},{"v":0.6358981,"d":"0.636"},{"v":0.483029,"d":"0.4830"}]
[]
[]
[null,"Treatment group: Vehicle",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value","Overall P-value"]
[null,null,"Intercept",{"v":1.43848,"d":"1.438"},{"v":0.18362,"d":"0.184"},{"v":1.11654112,"d":"1.117"},{"v":1.7604528,"d":"1.760"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.64662,"d":"0.647"},{"v":0.28996,"d":"0.290"},{"v":0.13818545,"d":"0.138"},{"v":1.1550128,"d":"1.155"},{"v":0.07657,"d":"0.0766"},0.1192]
[null,null,"GenotypeTDP43-K145R vs TDP43-wt",{"v":-0.04853,"d":"-0.049"},{"v":0.25941,"d":"0.259"},{"v":-0.50338295,"d":"-0.503"},{"v":0.4062868,"d":"0.406"},{"v":0.859,"d":"0.8590"}]
[]
[]
[null,"GenotypeTDP43-K145Q ",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":2.0851,"d":"2.085"},0.513,{"v":1.1296577,"d":"1.130"},{"v":3.040539,"d":"3.041"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",4.534,{"v":0.6623,"d":"0.662"},{"v":3.3004993,"d":"3.300"},{"v":5.767437,"d":"5.767"},{"v":0.00638,"d":"0.0064"}]
[]
[]
[]
[null,"GenotypeTDP43-K145R",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":1.39,"d":"1.390"},{"v":0.2521,"d":"0.252"},{"v":0.9125098,"d":"0.913"},{"v":1.8673917,"d":"1.867"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",{"v":1.0979,"d":"1.098"},{"v":0.3565,"d":"0.357"},{"v":0.4226945,"d":"0.423"},{"v":1.7731013,"d":"1.773"},{"v":0.03694,"d":"0.0369"}]
[]
[]
[]
[null,"Genotype TDP43-wt",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":1.4395,"d":"1.440"},{"v":0.3576,"d":"0.358"},{"v":0.7624217,"d":"0.762"},{"v":2.1170575,"d":"2.117"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",{"v":1.5054,"d":"1.505"},{"v":0.5055,"d":"0.506"},{"v":0.5477439,"d":"0.548"},{"v":2.4627474,"d":"2.463"},0.0408]
[]
[]
[]
["Fig2b","Treatment group: NaAsO2",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":1.8642,"d":"1.864"},{"v":0.1171,"d":"0.117"},{"v":1.633811,"d":"1.634"},{"v":2.0946065,"d":"2.095"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":1.4362,"d":"1.436"},{"v":0.1655,"d":"0.166"},{"v":1.1103934,"d":"1.110"},{"v":1.7620565,"d":"1.762"},"<0.0001"]
[]
[]
[]
[null,"Treatment group: Vehicle",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.73127,"d":"0.731"},{"v":0.08742,"d":"0.087"},{"v":0.5715732,"d":"0.572"},{"v":0.8899468,"d":"0.890"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.21341,"d":"0.213"},{"v":0.1231,"d":"0.123"},{"v":-0.0104537,"d":"-0.010"},{"v":0.4382952,"d":"0.438"},0.2271]
[]
[]
[null,"GenotypeTDP43-K145Q ",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.9447,"d":"0.945"},{"v":0.0988,"d":"0.099"},{"v":0.75075,"d":"0.751"},{"v":1.1385981,"d":"1.139"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",{"v":2.3558,"d":"2.356"},{"v":0.1397,"d":"0.140"},{"v":2.0815089,"d":"2.082"},{"v":2.630009,"d":"2.630"},"<0.0001"]
[]
[]
[]
[null,"Genotype TDP43-wt",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.7321,"d":"0.732"},{"v":0.1014,"d":"0.101"},{"v":0.5479281,"d":"0.548"},{"v":0.9172039,"d":"0.917"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",{"v":1.1321,"d":"1.132"},{"v":0.1425,"d":"0.143"},{"v":0.8723448,"d":"0.872"},{"v":1.3909405,"d":"1.391"},0.0159]
[]
[]
["Fig2c","Treatment group: NaAsO2",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.60746,"d":"0.607"},{"v":0.04571,"d":"0.046"},{"v":0.5253617,"d":"0.525"},{"v":0.6895605,"d":"0.690"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.09414,"d":"0.094"},{"v":0.06465,"d":"0.065"},{"v":-0.02196486,"d":"-0.022"},{"v":0.2102473,"d":"0.210"},0.2826]
[]
[]
[]
[null,"Treatment group: Vehicle",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.5069,"d":"0.507"},{"v":0.1004,"d":"0.100"},{"v":0.32652092,"d":"0.327"},{"v":0.6872368,"d":"0.687"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.2396,"d":"0.240"},{"v":0.1418,"d":"0.142"},{"v":-0.01532012,"d":"-0.015"},{"v":0.4944538,"d":"0.494"},0.2328]
[]
[]
[null,"GenotypeTDP43-K145Q ",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.74645,"d":"0.746"},{"v":0.10749,"d":"0.107"},{"v":0.55340196,"d":"0.553"},{"v":0.9394893,"d":"0.939"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",{"v":-0.04484,"d":"-0.045"},{"v":0.15202,"d":"0.152"},{"v":-0.31784817,"d":"-0.318"},{"v":0.2281618,"d":"0.228"},0.7958]
[]
[]
[]
[null,"Genotype TDP43-wt",null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":0.50626,"d":"0.506"},{"v":0.02438,"d":"0.024"},{"v":0.45631502,"d":"0.456"},{"v":0.55668543,"d":"0.557"}]
[null,null,"TreatmentNaAsO2 vs Vehicle",{"v":0.1012,"d":"0.101"},{"v":0.03424,"d":"0.034"},{"v":0.03031331,"d":"0.030"},{"v":0.17160111,"d":"0.172"},{"v":0.00366,"d":"0.0037"}]
[]
[]
["Fig5b",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,"NeuN cells/mm2 12 months","Intercept",{"v":1408.63,"d":"1408.630"},{"v":51.77,"d":"51.770"},{"v":1293.46,"d":"1293.460"},{"v":1523.8,"d":"1523.800"},"<0.001"]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":108.47,"d":"108.470"},{"v":72.98,"d":"72.980"},{"v":-54.18,"d":"-54.180"},{"v":271.11,"d":"271.110"},{"v":0.168,"d":"0.1680"}]
[]
[]
["Fig5b",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,"NeuN cells/mm2 18 months","Intercept",{"v":1366.2,"d":"1366.200"},{"v":24.35,"d":"24.350"},{"v":1297.44,"d":"1297.440"},{"v":1434.97,"d":"1434.970"},"<0.001"]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":55.69,"d":"55.690"},{"v":37.02,"d":"37.020"},{"v":-41.49,"d":"-41.490"},{"v":152.87,"d":"152.870"},0.197]
[]
[]
["Fig5b",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,"NeuN cells/mm2 ","Intercept",{"v":1408.51,"d":"1408.510"},{"v":45.86,"d":"45.860"},{"v":1310.12,"d":"1310.120"},{"v":1506.9,"d":"1506.900"},"<0.001"]
[null,null,"Age (12 vs 18 months)",{"v":-38.73,"d":"-38.730"},{"v":73.41,"d":"73.410"},{"v":-195.75,"d":"-195.750"},{"v":118.29,"d":"118.290"},{"v":0.606,"d":"0.6060"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":92.76,"d":"92.760"},{"v":63.51,"d":"63.510"},{"v":-42.98,"d":"-42.980"},{"v":228.5,"d":"228.500"},{"v":0.165,"d":"0.1650"}]
[null,null,"Interaction of Age*Genotype",{"v":56.12,"d":"56.120"},{"v":89.37,"d":"89.370"},{"v":-127.64,"d":"-127.640"},{"v":239.87,"d":"239.870"},{"v":0.536,"d":"0.5360"}]
[]
["Fig5c",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,"%Occupied by NeuN 12 months","Intercept",{"v":10.82,"d":"10.820"},{"v":0.06,"d":"0.060"},{"v":10.69,"d":"10.690"},{"v":10.94,"d":"10.940"},"<0.001"]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.19,"d":"0.190"},{"v":0.08,"d":"0.080"},{"v":0.01,"d":"0.010"},{"v":0.37,"d":"0.370"},{"v":0.038,"d":"0.0380"}]
[]
[]
["Fig5c",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,"%Occupied by NeuN 18 months","Intercept",{"v":10.69,"d":"10.690"},{"v":0.13,"d":"0.130"},{"v":10.25,"d":"10.250"},{"v":11.04,"d":"11.040"},"<0.001"]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.19,"d":"0.190"},{"v":0.2,"d":"0.200"},{"v":-0.33,"d":"-0.330"},{"v":0.71,"d":"0.710"},0.387]
[]
[]
["Fig5c",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,"%Occupied by NeuN","Intercept",{"v":10.82,"d":"10.820"},{"v":0.07,"d":"0.070"},{"v":10.66,"d":"10.660"},{"v":10.97,"d":"10.970"},"<0.001"]
[null,null,"Age (12 vs 18 months)",{"v":-0.13,"d":"-0.130"},{"v":0.12,"d":"0.120"},{"v":-0.37,"d":"-0.370"},{"v":0.12,"d":"0.120"},{"v":0.295,"d":"0.2950"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.17,"d":"0.170"},{"v":0.1,"d":"0.100"},{"v":-0.05,"d":"-0.050"},{"v":0.38,"d":"0.380"},{"v":0.12,"d":"0.1200"}]
[null,null,"Interaction of Age*Genotype",{"v":0.08,"d":"0.080"},{"v":0.15,"d":"0.150"},{"v":-0.23,"d":"-0.230"},{"v":0.39,"d":"0.390"},{"v":0.605,"d":"0.6050"}]
[]
[]
["Fig5e",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",160.024,4.406,{"v":151.608432,"d":"151.608"},{"v":168.44919,"d":"168.449"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",11.701,6.721,{"v":-1.151044,"d":"-1.151"},{"v":24.54525,"d":"24.545"},0.1423]
[]
[]
["Fig5f",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":1.13508,"d":"1.135"},{"v":0.03653,"d":"0.037"},{"v":1.06523892,"d":"1.065"},{"v":1.20492206,"d":"1.205"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":-0.04585,"d":"-0.046"},{"v":0.05578,"d":"0.056"},{"v":-0.15250428,"d":"-0.153"},{"v":0.0607889,"d":"0.061"},0.4485]
[]
[]
["Fig4h",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",190.992,16.384,{"v":159.63233,"d":"159.632"},{"v":222.25452,"d":"222.255"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",19.289,24.942,{"v":-28.35785,"d":"-28.358"},{"v":67.0343,"d":"67.034"},{"v":0.474,"d":"0.4740"}]
[]
[]
["Fig4i",null,null,"Estimate","Std. Error","Confidence Intervals",null,"P-value"]
[null,null,"Intercept",{"v":1.75647,"d":"1.756"},{"v":0.07674,"d":"0.077"},{"v":1.60979469,"d":"1.610"},{"v":1.903169,"d":"1.903"}]
[null,null,"GenotypeTDP43-K145Q vs TDP43-wt",{"v":0.02498,"d":"0.025"},{"v":0.11558,"d":"0.116"},{"v":-0.19644603,"d":"-0.196"},{"v":0.2464099,"d":"0.246"},{"v":0.837,"d":"0.8370"}]